LOCUS       DBERMM010000001       157269 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.001, whole genome shotgun sequence.
ACCESSION   DBERMM010000001 DBERMM010000000
VERSION     DBERMM010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 157269)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 157269)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..157269
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.001"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            244..504
                     /locus_tag="ACL8AS_000001"
     CDS             244..504
                     /locus_tag="ACL8AS_000001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227952.1"
                     /translation="MTGVSNPTTDSARLVLAEAKKAFADDSLTEQGLRDILQTVKDAI
                     ASLESIKESQSATKDGGQTAGKETAGEDESANQTQEISQGIK"
     gene            458..679
                     /locus_tag="ACL8AS_000002"
     CDS             458..679
                     /locus_tag="ACL8AS_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227953.1"
                     /translation="MSLQIKLKKLAKELSKLLKDSNLETVDKDVLENSQKELQKAVLF
                     LADEKGSEHTEAEVIDNLKEVIAKLKANA"
     gene            998..1927
                     /locus_tag="ACL8AS_000003"
     CDS             998..1927
                     /locus_tag="ACL8AS_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1227954.1"
                     /translation="MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYH
                     MTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAII
                     LSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFY
                     ADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIP
                     QLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGM
                     AAAAGLYQSVVGLILVILSNLLARRVDPNSALF"
     gene            1941..2864
                     /locus_tag="ACL8AS_000004"
     CDS             1941..2864
                     /locus_tag="ACL8AS_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001075101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1227955.1"
                     /translation="MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVF
                     VIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNV
                     FITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVP
                     MLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTA
                     LGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMA
                     MVVVATLPIAILYPFFQRYFVKGLTIGGVKE"
     gene            3074..4549
                     /locus_tag="ACL8AS_000005"
     CDS             3074..4549
                     /locus_tag="ACL8AS_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1227956.1"
                     /translation="MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIK
                     MYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAF
                     ADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQ
                     NFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPV
                     ANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQD
                     TWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEK
                     SMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNW
                     ILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINT
                     GTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK"
     gene            4821..5807
                     /locus_tag="ACL8AS_000006"
     CDS             4821..5807
                     /locus_tag="ACL8AS_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-related sulfurtransferase"
                     /protein_id="HGS1227957.1"
                     /translation="MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADE
                     GINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEESEQAFKKMFVRYKKEIVHLGLE
                     DNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRN
                     FRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKD
                     PEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILT
                     SEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV"
     gene            5929..6789
                     /locus_tag="ACL8AS_000007"
     CDS             5929..6789
                     /locus_tag="ACL8AS_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4299 family protein"
                     /protein_id="HGS1227958.1"
                     /translation="MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQ
                     PLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTETDWRIIKSFLDALLAYT
                     GTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLA
                     QFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLV
                     DKEVQWEIDLVQITGDGSKPEDYEAIARLDYAKFLESLPSAFYHQLDANQLEVQPILG
                     QDFKTLAQEK"
     gene            complement(6861..7925)
                     /locus_tag="ACL8AS_000008"
     CDS             complement(6861..7925)
                     /locus_tag="ACL8AS_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6574 domain-containing protein"
                     /protein_id="HGS1227959.1"
                     /translation="MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADFDTPIGK
                     NTQVEEEVSQAEVELESQQEEKIETPEVGEARTEIEEKKASNSTEEESDLSKETEKVT
                     IAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIK
                     SPTSKFETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLT
                     LFSIISILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIA
                     SFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIIL
                     LFFVAEVALIGDYLRILAFL"
     gene            complement(7988..8899)
                     /locus_tag="ACL8AS_000009"
     CDS             complement(7988..8899)
                     /locus_tag="ACL8AS_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 domain-containing protein"
                     /protein_id="HGS1227960.1"
                     /translation="MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVY
                     DSRTEKLTFGKEVENLEITLHQHALTITDSFDDQIHISYHPSLSAHHDLITNQNDRTL
                     SLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILQLPKGRTLKGINISANRGQTTI
                     INASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAEN
                     IQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYK
                     TEKTDVKDQLIARSDDNIDLISTPSRR"
     gene            complement(8892..9485)
                     /locus_tag="ACL8AS_000010"
     CDS             complement(8892..9485)
                     /locus_tag="ACL8AS_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HGS1227961.1"
                     /translation="MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEEL
                     IASLGTPKAAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILV
                     TLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTILAQAKSAFILIFGSGLLAIGA
                     SSLVLLGISYVARFFGLLIVRLVQFVLKKGKRGNQHA"
     gene            complement(9472..9798)
                     /locus_tag="ACL8AS_000011"
     CDS             complement(9472..9798)
                     /locus_tag="ACL8AS_000011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HGS1227962.1"
                     /translation="MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLY
                     PILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGS
                     IRHDKN"
     gene            complement(9937..11103)
                     /locus_tag="ACL8AS_000012"
     CDS             complement(9937..11103)
                     /locus_tag="ACL8AS_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CynX/NimT family MFS transporter"
                     /protein_id="HGS1227963.1"
                     /translation="MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSL
                     GVLTSLPLLMFTLFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLM
                     VGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGL
                     ILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFY
                     TVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVS
                     LAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGL
                     SQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL"
     gene            11161..12318
                     /locus_tag="ACL8AS_000013"
     CDS             11161..12318
                     /locus_tag="ACL8AS_000013"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1227964.1"
                     /translation="MSSKVSGFQDKNGKVLKIMIEWWKEKFRRVVVTQNVESLLVSIV
                     ISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDTEFNSIR
                     LYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTETFVMNNVAIIQQGEFVCGGPRP
                     TIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNE
                     QLGRTEDNDIHYRIREYGYKIRYSPSILSYQYIRPTFKKMLHQKYLNGLWIGLTSHVQ
                     FKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGF
                     LIVMPFLLFSIHFAYGFGTIVGLIRGFKWKKEYKRTIIYLDKISQINKNML"
     gene            12360..14210
                     /locus_tag="ACL8AS_000014"
     CDS             12360..14210
                     /locus_tag="ACL8AS_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HGS1227965.1"
                     /translation="MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILF
                     YGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLS
                     YSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
                     GDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIER
                     VIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGR
                     QEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVY
                     HELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFK
                     NNIRGTYNVARAVDEAKVPKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTY
                     CAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAK
                     DGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVD
                     NQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE"
     gene            complement(14235..14555)
                     /locus_tag="ACL8AS_000015"
     CDS             complement(14235..14555)
                     /locus_tag="ACL8AS_000015"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227966.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVADRTDEVSSKHCFKVVDGTDEVS
                     SKHCFKVVDGTDEVSSKHCFEVVDRTDEVSNHTYGKATLTWFEEIFEEYKSLHNKTHI
                     TKVV"
     gene            complement(14605..15237)
                     /locus_tag="ACL8AS_000016"
     CDS             complement(14605..15237)
                     /locus_tag="ACL8AS_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HGS1227967.1"
                     /translation="MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIR
                     GFMGPPLESSFATCLSKDQISEAVQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPL
                     YITTTKDTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIII
                     GDTKFDMLGARETGIQKLAITWGFGEQADLLNYQPDYIAHKPLEVLAYFQ"
     gene            complement(15259..16131)
                     /gene="sdaAA"
                     /locus_tag="ACL8AS_000017"
     CDS             complement(15259..16131)
                     /gene="sdaAA"
                     /locus_tag="ACL8AS_000017"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0006094 - gluconeogenesis [Evidence IEA];
                     GO_process: GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="HGS1227968.1"
                     /translation="MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLME
                     RNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNE
                     HNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASI
                     SGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEV
                     PCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLAT
                     TPTGRRLQKEIFGE"
     gene            complement(16140..16811)
                     /gene="sdaAB"
                     /locus_tag="ACL8AS_000018"
     CDS             complement(16140..16811)
                     /gene="sdaAB"
                     /locus_tag="ACL8AS_000018"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0006094 - gluconeogenesis [Evidence IEA];
                     GO_process: GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="HGS1227969.1"
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPT
                     EVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKD
                     SNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDI
                     PGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHN
                     VNFFK"
     gene            17052..17639
                     /locus_tag="ACL8AS_000019"
     CDS             17052..17639
                     /locus_tag="ACL8AS_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HGS1227970.1"
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLS
                     EIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETV
                     SAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNG
                     DYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY"
     gene            complement(17691..18017)
                     /locus_tag="ACL8AS_000020"
                     /pseudo
     CDS             complement(17691..18017)
                     /locus_tag="ACL8AS_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
     gene            18436..18723
                     /locus_tag="ACL8AS_000021"
     CDS             18436..18723
                     /locus_tag="ACL8AS_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001230165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HGS1227971.1"
                     /translation="MRKLVKIGVASLMVCGILATTNALAVWVEGGQWNYGVGWTGTFG
                     YSDYLHSTRYHTATVRHGGRTSKDYAKPEAWAIASLTKIPPTGMEYFYGFE"
     gene            18775..20883
                     /locus_tag="ACL8AS_000022"
     CDS             18775..20883
                     /locus_tag="ACL8AS_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HGS1227972.1"
                     /translation="MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDL
                     YLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLD
                     FTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEM
                     DKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQP
                     MMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPML
                     WLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTAL
                     LIGVGRSLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFY
                     QDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTG
                     IKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFP
                     YSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKL
                     SDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRD
                     IITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVL
                     GLASRMEKRSLVELLKGGIL"
     gene            20880..21521
                     /locus_tag="ACL8AS_000023"
     CDS             20880..21521
                     /locus_tag="ACL8AS_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1227973.1"
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGALVAIVGKSGSGKSTLL
                     NLLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLML
                     ALKYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLIL
                     ADEPTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK"
     gene            21728..22534
                     /locus_tag="ACL8AS_000024"
                     /pseudo
     CDS             21728..22534
                     /locus_tag="ACL8AS_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            22551..22943
                     /locus_tag="ACL8AS_000025"
                     /pseudo
     CDS             22551..22943
                     /locus_tag="ACL8AS_000025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269502.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase domain-containing
                     protein"
     gene            complement(23260..23586)
                     /locus_tag="ACL8AS_000026"
                     /pseudo
     CDS             complement(23260..23586)
                     /locus_tag="ACL8AS_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268159.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
     gene            24344..24697
                     /locus_tag="ACL8AS_000027"
     CDS             24344..24697
                     /locus_tag="ACL8AS_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HGS1227974.1"
                     /translation="MELVLPNNYVVIDEEEMMYLDGGAYLSKRACQGICAALAMSPGT
                     FIALAGAAVLTKKLINYIKVGGLGGWLIGAAAGVLAGAAGRIAYCIGYGALNRGCDIS
                     GNPYPWDGFISATVR"
     gene            24694..25422
                     /locus_tag="ACL8AS_000028"
     CDS             24694..25422
                     /locus_tag="ACL8AS_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227975.1"
                     /translation="MSNVDKIRKIHIIVCWMYIFLSFRAIINDTEYFLLIFLAFIYSI
                     VSLPLYSVKNKIVSICLAINSILLMSFPILINKFFPESFLTYTVLISVFITELIIFHL
                     IGKDFDIKLTNEYKKISQFRSKVSQSPWIKYLEISSFILTIFPSILYGTVDNHVLTLI
                     FLIKICADTTIKFLFIRLFDTSTLMKRRIFFLFALDVIAYLFLGYLLVIQKAGYLFSV
                     LLLFSNFSVPFIKEKEYELFKNSK"
     gene            25901..26107
                     /locus_tag="ACL8AS_000029"
     CDS             25901..26107
                     /locus_tag="ACL8AS_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227976.1"
                     /translation="MKHFFAGIGEIKLVGYLLYICVGLAPLFHIYVIGSELSFVKIVL
                     SILGVIFVSMLTIARIYRTFFYKE"
     gene            26558..26797
                     /locus_tag="ACL8AS_000030"
     CDS             26558..26797
                     /locus_tag="ACL8AS_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227977.1"
                     /translation="MKLLDCILDYQERFNGKTCQVSTNYKYLETFKVNFCLTDLHHLF
                     GLYKITRDYASQTKPAIQAGVFILEDFRNILCTMM"
     gene            26782..27060
                     /locus_tag="ACL8AS_000031"
     CDS             26782..27060
                     /locus_tag="ACL8AS_000031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227978.1"
                     /translation="MYNDVIERISLYEFIGAIFYSKLTSCCIVAKDLSKNTMKLDVIF
                     FEDKNKRSAVLGLRRDKSGVFKPVTLHFTSAKKYAKVRKTDVKEMKWL"
     gene            27346..29475
                     /gene="pspA"
                     /locus_tag="ACL8AS_000032"
     CDS             27346..29475
                     /gene="pspA"
                     /locus_tag="ACL8AS_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein A"
                     /protein_id="HGS1227979.1"
                     /translation="MNKKKMILTSLASVAILGAGFVASQPTVVRAEAAPQVVEKSSLE
                     KKYEEAKAKADTAKKDYETAKKKAAEAQKKYEDDQKRTEEKGALEEETSRKVNDATLE
                     VQNAYVEYGEANKKKGKDREKKLADAQKKIDEAQEKLTKAKNEFQSVRAMVVPEPEQL
                     AETKKKAEEAKAEEAVAKEKSDKAAKEVEVAKKRVEAEEAELDKKVAELQNKVADLEK
                     EIADAEKTVADLEKEVAKLEKDVEDFKNSNGEQAEQYLAAAEKDLVAKKAELAEAKIK
                     AATKKAELEPELEKAEAELENLLSTLDPEGKTQDELDKEAAEAELNKKVEALQNQVAE
                     LEEELSKLEDNLKDAETNNVEDYIKEGLEEAIATKKAELEKTQKELDAALNELGPDGD
                     EEETPAPAPQPEKPAPAPAPKPEQPAPAPKPEKTDDQQAEEDYARRSEEEYNRLPQQQ
                     PPKAEKPAPAPKPEQPVPAPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNSNG
                     AMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNDSWYYLNA
                     NGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYL
                     NANGAMATGWAKVNGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKW
                     YYVNGLGALAVNTTVDGYKVNANGEWV"
     gene            29876..30997
                     /gene="mnmA"
                     /locus_tag="ACL8AS_000033"
     CDS             29876..30997
                     /gene="mnmA"
                     /locus_tag="ACL8AS_000033"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_function: GO:0016783 - sulfurtransferase activity
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HGS1227980.1"
                     /translation="MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDT
                     DENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVM
                     CNKEIKFKAFLDYAMTLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYFLSQLS
                     QEQLQKTMFPLGHLEKPEVRKLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQ
                     PGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQ
                     GFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFA
                     EPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI"
     gene            31138..31593
                     /locus_tag="ACL8AS_000034"
     CDS             31138..31593
                     /locus_tag="ACL8AS_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HGS1227981.1"
                     /translation="MTQQDFRTKVDNTVFGVRATALILQNRKLLVTKDKGKYYIIGGA
                     IQVNEKTEDAVVREVKEELGIKAQAGQLAFVVENRFEQDGVSYHNIEFHYLVDLLEDA
                     PLTMQEDEKRQPCEWIDLDKLQNIQLVPAFLKTALPDWEGQLRHIHLEE"
     gene            31603..33516
                     /gene="mnmG"
                     /locus_tag="ACL8AS_000035"
     CDS             31603..33516
                     /gene="mnmG"
                     /locus_tag="ACL8AS_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002098 - tRNA wobble uridine modification
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HGS1227982.1"
                     /translation="MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEML
                     AFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTA
                     LRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTE
                     IQPGDEAPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVG
                     PRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGL
                     ENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGI
                     NAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMR
                     LTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTD
                     AVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMK
                     RMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEG
                     KNRSISKTLQKSK"
     gene            complement(33711..35390)
                     /locus_tag="ACL8AS_000036"
     CDS             complement(33711..35390)
                     /locus_tag="ACL8AS_000036"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004540 - RNA nuclease activity [Evidence
                     IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HGS1227983.1"
                     /translation="MAYTLKPEEVGVFAIGGLGEIGKNTYGIEYQDEIIIVDAGIKFP
                     EDDLLGIDYVIPDYSYIVDNIDRVKAVLITHGHEDHIGGIPFLLKQANVPIYAGPLAL
                     ALIRGKLEEHGLLRNAKLYEINHNTELTFKNLKATFFRTTHSIPEPLGIVIHTPQGKI
                     VCTGDFKFDFTPVGEPADLHRMAALGEEGVLCLLSDSTNAEVPTFTNSEKVVGQSIMK
                     IIQGIEGRIIFASFASNIFRLQQATEAAVKTGRKIAVFGRSMEKAIVNGIDLGYIKAP
                     KGTFIEPNEIKDYPAGEVLILCTGSQGEPMAALSRIANGTHRQVQLQPGDTVIFSSSP
                     IPGNTTSVNKLINIISEAGVEVIHGKVNNIHTSGHGGQQEQKLMLRLIKPKYFMPVHG
                     EYRMQKVHAGLAVDTGVEKDNIFIMSNGDVLALTADSARIAGHFNAQDIYVDGNRIGE
                     IGAAVLKDRRDLSEDGVVLAVATVDFKSQMILSGPDILSRGFVYMRESGDLIRQSQRI
                     LFNAIRIALKNKDASVQSVNGAIVNAIRPFLYENTEREPIIIPMILTPDEE"
     gene            complement(35392..35625)
                     /locus_tag="ACL8AS_000037"
     CDS             complement(35392..35625)
                     /locus_tag="ACL8AS_000037"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002947111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-dependent RNA polymerase subunit epsilon"
                     /protein_id="HGS1227984.1"
                     /translation="MIYKVFYQETKERSPRRETTRALYLDIDASSELEGRITARQLVE
                     ENRPEYNIEYIELLSDKLLDYEKETGAFEITEF"
     gene            35905..36120
                     /locus_tag="ACL8AS_000038"
                     /pseudo
     CDS             35905..36120
                     /locus_tag="ACL8AS_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282487.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(36443..36595)
                     /gene="cibB"
                     /locus_tag="ACL8AS_000039"
     CDS             complement(36443..36595)
                     /gene="cibB"
                     /locus_tag="ACL8AS_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibB"
                     /protein_id="HGS1227985.1"
                     /translation="MMKDLNNYREISNKELQEIKGGFGVGVGIALFMAGYTIGKDLRK
                     KFGKSC"
     gene            complement(36597..36782)
                     /gene="cibA"
                     /locus_tag="ACL8AS_000040"
     CDS             complement(36597..36782)
                     /gene="cibA"
                     /locus_tag="ACL8AS_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000180803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibA"
                     /protein_id="HGS1227986.1"
                     /translation="MTNFDILDNQFLSLSENELSDIDGGLAPLVIFGVAVSWKAIAGG
                     TALIGSGLAAGYFLGGD"
     gene            36960..37643
                     /gene="tsaB"
                     /locus_tag="ACL8AS_000041"
     CDS             36960..37643
                     /gene="tsaB"
                     /locus_tag="ACL8AS_000041"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HGS1227987.1"
                     /translation="MKVLAFDTSSKALSLAILEDKQVLAETTINIKKNHSITLMPAID
                     FLMASLDWTPKDLDRIVVAEGPGSYTGLRIAVATAKTLAYTLNIELVGMSSLLALVPH
                     QQEGLFVPLMDARRNNVYAGFYENAKPVMAEAHLSFEEVLEKVKGTSQVTFVGEVAPF
                     VEQIQEYLPRTNFKETLPNAANLALLAWDKEADSLHDFVPNYLKRVEAEENWLKNHTE
                     SGESYIKRL"
     gene            37640..38077
                     /gene="rimI"
                     /locus_tag="ACL8AS_000042"
     CDS             37640..38077
                     /gene="rimI"
                     /locus_tag="ACL8AS_000042"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008999 -
                     peptide-alanine-alpha-N-acetyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HGS1227988.1"
                     /translation="MIEIKRIQQRPDLAQAIYAVMVAVYPVSPWTLEQIQADLSQDQT
                     WYVLAYDGAEVIGFLAVQENLFEAEVLQIAVKEAYQGQGIASALFAQLPTDKEIFLEV
                     RQSNHRAQAFYKKEKMAVIADRKAYYHDPVEDAIIMKREIDEG"
     gene            38067..39077
                     /gene="tsaD"
                     /locus_tag="ACL8AS_000043"
     CDS             38067..39077
                     /gene="tsaD"
                     /locus_tag="ACL8AS_000043"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HGS1227989.1"
                     /translation="MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGG
                     VVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFA
                     WAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDELVHQGQDIYDFPRAMIKEDNLEFSFSGLKSA
                     FINLHYNAEQKGESLSTEDLCASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANK
                     GLRERLAAEITDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFAGWDLNAKPSLAFDT
                     ME"
     gene            complement(39117..40351)
                     /locus_tag="ACL8AS_000044"
                     /pseudo
     CDS             complement(39117..40351)
                     /locus_tag="ACL8AS_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011680908.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(40686..41377)
                     /locus_tag="ACL8AS_000045"
                     /pseudo
     CDS             complement(40686..41377)
                     /locus_tag="ACL8AS_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001839528.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            41620..42174
                     /locus_tag="ACL8AS_000046"
     CDS             41620..42174
                     /locus_tag="ACL8AS_000046"
                     /inference="COORDINATES: protein motif:HMM:NF024831.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HGS1227990.1"
                     /translation="MQYSCGKININIPDGYGDIKDIVFSAHIIVRYNNGHCGGIDPHI
                     IGLCKKQIRRMSLYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALHVKNILK
                     LLKIQLIHCHGYSTNYFLYMLKKLDKNGFGKVKTVITCHGWVEYNLKKKFLTYFDFWT
                     YSMGDAFICVSETMKKKIGEYNKK"
     gene            42152..42826
                     /locus_tag="ACL8AS_000047"
     CDS             42152..42826
                     /locus_tag="ACL8AS_000047"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: protein motif:HMM:NF012744.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HGS1227991.1"
                     /translation="MESIIKNKKIVAINNGINVSNSDLDVVGVQDFKKEFCIPNNKKI
                     ICYVGRLDPEKRPDRFLEFAEKLFLVREDVIFIMAGNGSMWAALKEKICHLKCRDNFR
                     LLGEIYPATIVYQISDLLYIPSDTEGIPMCVLESMSQGTPVLASNVGGLSEIIEHRVD
                     GFLFEKEDVEGVCACANFLLNDSEYLKYIGENSKSKIRKHFSVQKMFVETMRVYDELL
                     EKSSHG"
     gene            42819..43691
                     /locus_tag="ACL8AS_000048"
     CDS             42819..43691
                     /locus_tag="ACL8AS_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000375706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1227992.1"
                     /translation="MDRNIDQELVSIIIPTHNRYESLIRAVKSCLHQSYKNIEVIIID
                     DNYSNVNLRNKIIHQFGYTNHRIKLILSNEDLGATNARNIGIKNSRGKYISFLDDDDE
                     YMPDRILKLMACFKKSRMKNLALVYSYGIIIYPNGTREEEKTDFVGNPLFVQMVHNIA
                     GTSFWLCKKEVLELINGFEKIDSHQDGVVLLKLLAQGYQIDIVREFLVNYYAHSKENG
                     ITGVTQKTINADEEYYNYCRKYFNLLSFNERILVTKKYYSLNIKRLLLIGDKCKALKV
                     IKKAREEKIFNEFF"
     gene            43778..45394
                     /locus_tag="ACL8AS_000049"
     CDS             43778..45394
                     /locus_tag="ACL8AS_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1227993.1"
                     /translation="MYTIIKSNIKKFSLLTIFIVAGQLLLIYAATINALVLNELIAMN
                     LERFLKLSIYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRNRVATDISNSTYQEFHS
                     KSSGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLFSLM
                     IMLLVPKIFASKMREVSLNLTNQNEAFLKSSETILNGFDVLASLNLLYVLPKKIKEAG
                     ILLKMVIQRKTTVETLAGAISFFLNIFFQISLVFLTGYLAIKGIVKIGTIEAIGALTG
                     VIFTALGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPNEVNRDFPLYEAKNIC
                     YKYGDKEILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGFLRDYSGELRFCGDDIK
                     KTSYLNMVSNVLYVDQKAYLFEGTIRDNILLEENYTDEEILQSLEQVGLSVKDFPNNI
                     LDYYVGDDGRLLSGGQKQKITLARGLIRNKKIVLIDEGTSAIDRRTSLAIERKILDRE
                     DLTVIIVTHAPHPELKQYFTKIYQFPKDFI"
     gene            45653..46081
                     /locus_tag="ACL8AS_000050"
     CDS             45653..46081
                     /locus_tag="ACL8AS_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001290269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227994.1"
                     /translation="MSEIVEMSKKISDLNDKKEFHKKNCELRFQDSVLDNINSVPGTT
                     HLFSCLNIQILVKIILYIFRYNSCMKIFNFRDKELIFFNKIVNGLIQNIEENLEDDIE
                     RILKYLYICLFNEIFIIKNKVNFFDDVEFNQTLSEFLDKL"
     gene            46093..46842
                     /locus_tag="ACL8AS_000051"
     CDS             46093..46842
                     /locus_tag="ACL8AS_000051"
                     /EC_number="3.5.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0019213 - deacetylase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HGS1227995.1"
                     /translation="MSNNTKYIFLSPHLDDAIFSCGDYISKLTSEGEIVLVITIFSGY
                     PLSQQLQSSAKQFHKLCNLGKYPIEERKKEDRLACERLQCDFRHLSYYECLYRKDRNG
                     NFLYRHIYSELKNEDTLKNDIIKELLMHLDDKCVVYCPLSLGDHVDHVFVNSIGRALE
                     FMRYKVIYYEDFPYVSDSSMVSYMGKTKELKIYQEELDKKHYIDRISSILCYKSQILI
                     IWKSVEKLLNNIKELYLRNGAAYSIIFWIKK"
     gene            46855..48027
                     /locus_tag="ACL8AS_000052"
     CDS             46855..48027
                     /locus_tag="ACL8AS_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="HGS1227996.1"
                     /translation="MNIAVIGLGHVGLAYALLFASKYKVVAYDIDSVKINNLKKGILP
                     SKNEELMKFFCENNLNITFFDTFSEIKNNIDYYIIALPTDYDEKIGSFNTYEIEQTVS
                     KILRVKPNGKIILKSTVPIGFSNKLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVV
                     GDETVEGRKIAELFLSISTHSTANIKNVMLVSPTEAEAIKLFSNTFLALRVAFFNELD
                     SFAERRSLNAEVVIKGVCLDPRIGNFYNNPSFGFGGYCLPKDTKQLKKEFIEINAPVI
                     EAIDISNTNRKQFIVKQILERKPKIVGIYKLGMKYNSDNYKESAILSIINELLIVGIK
                     ILVYEPNLNVSIDNVIFEKNFELFTKQSDLIVANRWDRGLEAYKDKVYTRGIWIRD"
     gene            48421..49284
                     /locus_tag="ACL8AS_000053"
     CDS             48421..49284
                     /locus_tag="ACL8AS_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HGS1227997.1"
                     /translation="MIEKMELGEFYKELRLARKLKQTDVACEGLTASQLSKFELGQSM
                     LSADKLILAIQGINVTFDEFGHKLNNYQESPHMRIGRKVVNRFAHQDIAALEQLLEEV
                     DQEQMAQTYRRLNAIVIKDAIHSLNKSYPLAEEDSEFLTTYLYAIESWTWFELYLFCN
                     TMPFLSNQDLIFLSTSLLEKSKEFKELVYNRLYMKQGLLNILSELMERKLFSYIPIFE
                     AELERMLRPYDVFEKVSWQFLKKMSVFLQTKGSNQKEIERFIQSLQVLENPQLTSLFE
                     LRFQQYKELID"
     gene            49575..49808
                     /locus_tag="ACL8AS_000054"
     CDS             49575..49808
                     /locus_tag="ACL8AS_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1227998.1"
                     /translation="MLNLQFAETMELTEAELQDVRGGNLVNSMGGGGRSGISGWGVPG
                     IYPGWGNQGMSPNRGAFDWTIDLADGLFGRRRR"
     gene            49830..50507
                     /locus_tag="ACL8AS_000055"
     CDS             49830..50507
                     /locus_tag="ACL8AS_000055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="HGS1227999.1"
                     /translation="MKKMKEVKFHLATGLLILTYYLIFNVTSDLDFMVALSDNMYYVF
                     QVLLVLILGTIATIAFVKSEHWKECGRFQFRWFYLGVFLLSFFLLFVWANLTTYIFPR
                     TQNGSTVVEVATNLTGISYFVTRILYTSIIAPVSEEVVCRGLLMTSLSKVKRYYLDVL
                     VSAAIFGAMHVLQYGWITTDFIKYFGMGLIFCMMFRYTRSIYWAIALHASWNSFLLIV
                     TLLVFGY"
     gene            50519..51184
                     /locus_tag="ACL8AS_000056"
     CDS             50519..51184
                     /locus_tag="ACL8AS_000056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysostaphin resistance A-like protein"
                     /protein_id="HGS1228000.1"
                     /translation="MKKIISHRYFIIVFLLVIADQKFSVLVLRSDLVTGLSDFAYYLS
                     DMMLNFLVVLFALIAMIWSGKWQKINSRKFKGSYLFYSFLALLAFVVWNFVTFFLFPP
                     TRNEISYQYAAPTFTGATAFLMYFFYPVIAGPIFEEIIHRGLVMTVLEKGKKWGLDVL
                     GSAVLFGVSHISNHGWVLTDFVFYMGGGLIFAVLFRMTKSIYWPIGLHIVYNGIGQLL
                     MLL"
     gene            51256..52482
                     /locus_tag="ACL8AS_000057"
     CDS             51256..52482
                     /locus_tag="ACL8AS_000057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HGS1228001.1"
                     /translation="MKVFLQNRDFRQLTINQWISTLGDTIFYLAFLNYVADASFAPLA
                     ILLITISETLPQVLQIFLGVLADFQHHRVLKYTVISFAKFLLYSIVSLSLSGQSFSLL
                     LVAFICLINLLSDTLSYFSGAMLTPIFIRIIGQDHLAEAIGFKQSTVSLVKTISNILG
                     GVLLGILSIQFISLLNALTFLIAFLGILFIKTDLLKVEKTINYQEGLSVKSFCQHLLQ
                     SSKLIWNMNKVLLVLFIISTSQAVINVTVPVSTLFLRNQPFLNLQTGQSLALLSTFEL
                     SALIVGSLVSGYLQHTISIKTALYASLVIQLLLLVGFATVRFDWILIFSTLDAFFAGV
                     LSPRLQELVFKQIPEESMGAVQSSISAITVVLPSLFTISLVTIATSFGTLAVSFVLLL
                     FLLVAFVMLLNIRESI"
     gene            52744..53400
                     /locus_tag="ACL8AS_000058"
     CDS             52744..53400
                     /locus_tag="ACL8AS_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HGS1228002.1"
                     /translation="MPTALGYVSIGLACGIIGAPYVTPVEMGLMSLFVYAGSAQFAML
                     ALIVVQAPVAAIAMTVFLINLRLFLLSLHASTYFRHTSLWYNIGMSSILTDETYGVLM
                     GELAHTDKVNPMWMHGNNLNSYVAWFVGTVVGTALGGLLPNPEIFGLDFALVGMFIGI
                     FASQFQIMQRRIPVRNLLIILAVVAVSFFLLLTVVSQSLAVLFATLLGCSMGVVLDGQ
                     "
     gene            53390..53713
                     /locus_tag="ACL8AS_000059"
     CDS             53390..53713
                     /locus_tag="ACL8AS_000059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000253911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HGS1228003.1"
                     /translation="MVSKYLLLAVIFSGLVTWILRMIPFILVKYKGLPAIVERFLKFL
                     PVSIIFALILSSVVTGKVGSLPQIKWLDFLAVFPTAWVAFRYRNLVGTVLFGVVLIAI
                     LRLVF"
     gene            53817..54647
                     /locus_tag="ACL8AS_000060"
     CDS             53817..54647
                     /locus_tag="ACL8AS_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1228004.1"
                     /translation="MKKIVKYSSLAALGLVAAGLLAACSGGAKKEGEAASKKEIIVAT
                     NGSPRPFIYEENGELTGYEIEVVRAIFKDSDKYDVKFEKTEWSGVFAGLDADRYNMAV
                     NNLSYTKERAEKYLYAAPIAQNPNVLVVKKDDSSIKSLDDIGGKSTEVVQATTSAKQL
                     EAYNAEHTDNPTILNYTKADFQQIMVRLSDGQFDYKIFDKIGVETVIKNQGLDNLKVI
                     ELPSDQQPYVYPLLAQGQDELKSFVDKRIKELYKDGTLEKLSKQFFGDTYLPAEADIK
                     "
     gene            54801..55655
                     /locus_tag="ACL8AS_000061"
     CDS             54801..55655
                     /locus_tag="ACL8AS_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000694494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HGS1228005.1"
                     /translation="MKIKKWLGLAALATVAGLALAACGNSEKKADNATTIKIATVNRS
                     GSEEKRWDKIQELVKKDGITLEFTEFTDYSQPNKATADGEVDLNAFQHYNFLNNWNKE
                     NGKDLVAIGDTYISPIRLYSGLNGSANKYTKVEDIPANGEIAVPNDATNESRALYLLQ
                     SAGLIKLDVSGTALATVANIKENPKNLKITELDASQTARSLSSVDAAVVNNTFVTEAK
                     LDYKKALFKEQADENSKQWYNIIVAKKDWETSPKADAIKKVIAAYHTDDVKKVIEETS
                     DGLDQPVW"
     gene            55755..57128
                     /locus_tag="ACL8AS_000062"
     CDS             55755..57128
                     /locus_tag="ACL8AS_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HGS1228006.1"
                     /translation="MVFPSEQEQIEKFEKDHVAQHYFEVLRTLISKKSVFAQQVGLKE
                     VANYLGEIFKRVGAEVEIDESYTAPFVMAHFKSSRPDAKTLIFYNHYDTVPADGDQVW
                     TEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQHHDDLPVNISFIMEGAEESA
                     STDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNKGIVTFDAKVKSADVDIH
                     SSYGGVVESAPWYLLQALQSLRAADGRILVEGLYEEVQEPNEREMALLETYGQRNPEE
                     VIRIYGLELPLLQEERMAFLKRFFFDPALNIEGIQSGYQGQGVKTILPAEASAKLEVR
                     LVPGLEPHDVLEKIRKQLDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYP
                     QGVSVLPTTAGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVE
                     ELIRSYE"
     gene            57121..58182
                     /locus_tag="ACL8AS_000063"
     CDS             57121..58182
                     /locus_tag="ACL8AS_000063"
                     /EC_number="7.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0048473 - D-methionine transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HGS1228007.1"
                     /translation="MSRDIIKLDQIDVTFHQKKRTITAVKDVTIHIQEGDIYGIVGYS
                     GAGKSTLVRVINLLQKPSAGKITIDDDVIFDGKVTLTAEQLRRKRQDIGMIFQHFNLM
                     SQKTAEENVAFALKHSELSKEEKKAKVAKLLDLVGLADRAENYPSQLSGGQKQRVAIA
                     RALANDPKILISDESTSALDPKTTKQILALLQDLNQKLGLTVVLITHEMQIVKDIANR
                     VAVMQDGHLIEEGSVLEIFSDPKQPLTQDFISTATGIDEAMVKIEKQEIVEHLSENSL
                     LVQLKYAGSSTDEPLLNELYKHYQVTANILYGNIEILDGTPVGELVVVLSGEKAALAG
                     AQEAIRQAGVQLKVLKGGQ"
     gene            58184..58876
                     /locus_tag="ACL8AS_000064"
     CDS             58184..58876
                     /locus_tag="ACL8AS_000064"
                     /EC_number="7.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0048473 - D-methionine transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter permease"
                     /protein_id="HGS1228008.1"
                     /translation="MESLIQTYLPNVYKMGWAGQAGWGTAIYLTLYMTVLSFIIGGFL
                     GLVAGLFLVLTAPGGVLENKVVFWILDKITSIFRAVPFIILLAILSPLSHLIVKTSIG
                     PNAALVPLSFAVFAFFARQVQVVLAELDGGVIEAAQASGATFWDIVGVYLSEGLPDLI
                     RVTTVTLISLVGETAMAGAVGAGGIGNVAIAYGFNRYNHDVTILATIIIILIIFAIQF
                     LGDFLTKKLSHK"
     gene            complement(58906..59475)
                     /locus_tag="ACL8AS_000065"
     CDS             complement(58906..59475)
                     /locus_tag="ACL8AS_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HGS1228009.1"
                     /translation="MKKSILTTLLFAVLYFLCMGIGVLLGNLFDQTGNMFYAPAFTAL
                     VGGSVYMILVAKVPRFGAITTIGLVIALFFLGTKHGAGSFLPGIICGLLADGVAHLGK
                     YKDKTKNFLSFIIFAFSTTGPILLMWIAPKAYMATLLARGKSQEYIDRIMVAPNPGTV
                     LLFIASIVIGALVGALIGQALSKKFAQKI"
     gene            59610..60224
                     /locus_tag="ACL8AS_000066"
     CDS             59610..60224
                     /locus_tag="ACL8AS_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000532354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HGS1228010.1"
                     /translation="MGRFLDFVFNRFFLGMIATAFFWLLTLAGGIILGLAPASATLMS
                     LYAEHGYSFREYSLKEAWSLYKQNFISSNLIFYSFLGVGLVLTYGLYLLVQLPHQTIV
                     HLIATLLNVLVVALIFLAYTVSLKLQVYFALSYRNSLKLSLIGIFMSLAAVAKVLLGT
                     VLLVAIGYYMPALLFFVGIGMWHFFISDMLEPVYEIIHEKLATK"
     gene            60202..61872
                     /locus_tag="ACL8AS_000067"
     CDS             60202..61872
                     /locus_tag="ACL8AS_000067"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HGS1228011.1"
                     /translation="MKNWRQNRMKHFWLHTLLRTYSSVMIIIIASFAILLSYADWDSR
                     EKEAQRVAQRVTARTVSEIEYYHRESTQIAQALVENQARIEGIYKYFSLSMPDYFYWQ
                     LERKASPYISVSLYENVDDLYVRNDFVTGVAIAFQDYKEVYVSTKDKRSGEKIRAEDF
                     KPAGNSFAIPVSDPVSDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIF
                     HIGETVDKESENWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLT
                     LRQTFANYQKQVVDLVESIQVIAQGEEGRRIDISEKDQELLLIAETTNDMLDRLEKNI
                     HDIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLR
                     NNISDERETLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVE
                     NYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQRYFEHQ
                     ASYSDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGVQYRITIQDE"
     gene            61884..63170
                     /locus_tag="ACL8AS_000068"
     CDS             61884..63170
                     /locus_tag="ACL8AS_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HGS1228012.1"
                     /translation="MYKVLLVDDEYMVTEGLKRLIPFDKWDMEVVATAGHADEALEYV
                     QENPVDVIISDVNMPDKTGLDMIREMKEILPDAAYILLSGYQEFDYVKRAMNLSVVDY
                     LVKPVDKVELGNLLEKIAGQLGERGKKSQTLSQELDEAGFVSYLGDKENWWIGLSKEK
                     QGSFTIPYYVLGQDWQIFISGQPLDGLVVTPFEAPYQEHFERWKLNAEKTLFYGSVNL
                     QQSESLFAYYEPIYRVIIQGNLNQIVEELNLLEKVVLENTPRVPITKQLFIQFVMDVF
                     HLFEHLKADDLTDIVKTIHAIQSFDELVPYIKETLTSFFGQYRMNENVASVLEVIGRD
                     YQKELSLKDISKALFINPVYLGQLIKRETDSTFAELLNKQRIKAAQQLLLSTSDSIED
                     ICYAVGYSNLGYFYKVFRKLCGKSPKAYRKQVETIL"
     gene            63222..63755
                     /locus_tag="ACL8AS_000069"
     CDS             63222..63755
                     /locus_tag="ACL8AS_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228013.1"
                     /translation="MKKKPIYLWVLLILSALISVPSLFGIVSPLPSKEALRAAQKQVA
                     GVNAQQLEDQLNYTYRVAEASHSIFNVALIVLSTILVVVAIVFLVRKNLQYANYTYVG
                     YVLLAIIGSIYGYVGLQDAVQLVQDESMRLTVSIGSKAVSIFYIVINVLFLALVFYKM
                     WRQQKALAEEEETEELA"
     gene            63833..64303
                     /gene="nrdI"
                     /locus_tag="ACL8AS_000070"
     CDS             63833..64303
                     /gene="nrdI"
                     /locus_tag="ACL8AS_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HGS1228014.1"
                     /translation="MKTISLVYISLSGNTESFVTRLKDYLLSQYKGIEVQKIHIKDLV
                     KEGKNFYEMDHPYVAFLPTYLEGGNGVDNGDVEILTTPVGDFIAYGNNASKCFGVVGS
                     GNRNFNNQYCLTAKQYSQRFGFPVLADFEMRGMLEDIKHVAAIIADLYELEKEN"
     gene            complement(64596..65858)
                     /locus_tag="ACL8AS_000071"
     CDS             complement(64596..65858)
                     /locus_tag="ACL8AS_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NRAMP family divalent metal transporter"
                     /protein_id="HGS1228015.1"
                     /translation="MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGS
                     YGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKLYLWIFFILNVFSAM
                     VNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSA
                     LTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWS
                     AEKRKTVNFNTEDALFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQF
                     VGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLN
                     IWMTITAIIGIVIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWL
                     KHLAIAGLIFLFGFAIFFIYALAIGKAG"
     gene            complement(66168..66626)
                     /locus_tag="ACL8AS_000072"
     CDS             complement(66168..66626)
                     /locus_tag="ACL8AS_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3021 domain-containing protein"
                     /protein_id="HGS1228016.1"
                     /translation="MKKQVFHDAAAGVLIGLILSILFSLIYAPNTYAPLNPYSLIGQV
                     MDQHQVHGALVLLYCTLIWAAIGMLFNFGNRLFSRDWSMLRATLTHFFLMLAGFVPLA
                     TLAGWFPFHWIFYLQLIIEFAIVYLIIWAILYKREAKKVDHINQLLEHRK"
     gene            complement(66623..67063)
                     /locus_tag="ACL8AS_000073"
     CDS             complement(66623..67063)
                     /locus_tag="ACL8AS_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000861967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="HGS1228017.1"
                     /translation="MKVELQISETYEEEKLIVQAPQETEKVQKVIEFAENLDQREKIK
                     GKIDDQVYLVEIGKIQRFYIENRKVLAETASQTYSIDLRLYQVLKLLPSNFIQISQSE
                     IINIDSISHLKLTPNGLVEIFLKNESFTYSSRRYLKTIKEKLEL"
     gene            67419..69368
                     /gene="mutL"
                     /locus_tag="ACL8AS_000074"
     CDS             67419..69368
                     /gene="mutL"
                     /locus_tag="ACL8AS_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0032300 - mismatch repair complex
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006298 - mismatch repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HGS1228018.1"
                     /translation="MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQII
                     IEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPS
                     IASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
                     MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSA
                     KKMIEIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKL
                     MVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMALVSEAIANSLKEQTLIPD
                     ALENLAKSTVRNREKVEQTILPLKENTFYYEKTEPSRPSQTEVADYQVELTDEGQDLT
                     LFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELE
                     FFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFP
                     ADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTK
                     EVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHF
                     TKSDMEKMFRRIQENHTSLRELGKY"
     gene            complement(69693..70160)
                     /gene="ribE"
                     /locus_tag="ACL8AS_000075"
     CDS             complement(69693..70160)
                     /gene="ribE"
                     /locus_tag="ACL8AS_000075"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009349 - riboflavin synthase complex
                     [Evidence IEA];
                     GO_function: GO:0000906 - 6,7-dimethyl-8-ribityllumazine
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HGS1228019.1"
                     /translation="MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVN
                     EKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQ
                     ISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA"
     gene            complement(70161..71366)
                     /locus_tag="ACL8AS_000076"
     CDS             complement(70161..71366)
                     /locus_tag="ACL8AS_000076"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003935 - GTP cyclohydrolase II activity
                     [Evidence IEA];
                     GO_function: GO:0008686 -
                     3,4-dihydroxy-2-butanone-4-phosphate synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HGS1228020.1"
                     /translation="MEYRKIQEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTEN
                     VNFMATYAKGLICMPMSESLANQLMLSPMVENNTDNHKTAFTVSIDYKETTTGISAEE
                     RGLTARMCVAEDITPSDFRRPGHMFPLIAKKGGVLERNGHTEATVDLLKLAGLKECGL
                     CCEIMNHDGKMMRTDDLIQFSKKHNIPLITIKELQEYRKVYDQLVERVSTVNMPTRYG
                     NFKAISYIDKLNGEHHLALIMGNIEDEANVLCRVHSECLTGDVLGSLRCDCGQQFDKA
                     MKMIVENGSGVLLYLRQEGRGIGLINKLKAYHLQDQGMDTLDANLALGFEGDLREYHI
                     GAQMLKDLGLQSLHLLTNNPDKVEQLEKYGITISSRISIEIEANPYDSFYLETKKNRM
                     GHILNMEEK"
     gene            complement(71386..72021)
                     /gene="ribE"
                     /locus_tag="ACL8AS_000077"
     CDS             complement(71386..72021)
                     /gene="ribE"
                     /locus_tag="ACL8AS_000077"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004746 - riboflavin synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HGS1228021.1"
                     /translation="MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVN
                     GICLTVTHFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSVNGRLGGHVVTGHI
                     DGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKVSKVNFSVSVI
                     PHTLEQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSEISKELLYQNGF"
     gene            complement(72006..73106)
                     /gene="ribD"
                     /locus_tag="ACL8AS_000078"
     CDS             complement(72006..73106)
                     /gene="ribD"
                     /locus_tag="ACL8AS_000078"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA];
                     GO_function: GO:0008835 -
                     diaminohydroxyphosphoribosylaminopyrimidine deaminase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HGS1228022.1"
                     /translation="MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHE
                     FFGGSHAERNALKNCRESPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLD
                     CNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMSMDGK
                     IATKTNQSKWITEEEARKHVHQLRHHVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRII
                     CDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSS
                     LMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISL
                     PNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE"
     regulatory      complement(73240..73354)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            73511..74104
                     /gene="ruvA"
                     /locus_tag="ACL8AS_000079"
     CDS             73511..74104
                     /gene="ruvA"
                     /locus_tag="ACL8AS_000079"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000271492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009379 - Holliday junction helicase
                     complex [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0009378 - four-way junction helicase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HGS1228023.1"
                     /translation="MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQED
                     QIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIE
                     TKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDDLPAKVAVQASAENQELEEAMEAM
                     LALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK"
     gene            74114..74677
                     /locus_tag="ACL8AS_000080"
     CDS             74114..74677
                     /locus_tag="ACL8AS_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase I"
                     /protein_id="HGS1228024.1"
                     /translation="MTKRCSWVKMTNPLYIAYHDEEWGQPLHDDQALFELLCMETYQA
                     GLSWETVLNKRQAFREAFHSYQIHSVAEMTDTELEAMLENPAIIRNRAKIFATRANAQ
                     AFLQLQAEYGSFDAYLWSFVEGKTVVNDVPDYRQAPAKTPLSEKLAKDLKKRGFKFTG
                     PVAVLSFLQAAGLVDDHENDCEWRGLK"
     gene            74674..75351
                     /locus_tag="ACL8AS_000081"
     CDS             74674..75351
                     /locus_tag="ACL8AS_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000987430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="HGS1228025.1"
                     /translation="MMSNKNKGILIFAILYTVLFVFDGVKLLASLMPSAIANYLVYVV
                     LALYGSFLFKDRLIQQWKGIRKTKRKFFFGVLTGWLFLILMTVVFEFVSEMLKQFVGL
                     DGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLSGLLSIILV
                     GLVFALTHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLII
                     LAISIVK"
     gene            complement(75488..76519)
                     /locus_tag="ACL8AS_000082"
     CDS             complement(75488..76519)
                     /locus_tag="ACL8AS_000082"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S66 peptidase family protein"
                     /protein_id="HGS1228026.1"
                     /translation="MVSTIGIVSLSSGIIGEDFVKHEVDLGIQRLKDLRLNPIFLPHS
                     LKGLDFIKDHPEARAEDLIHAFSDDSIDMILCAIGGDDTYRLLPYLFENDQLQKVIKQ
                     KIFLGFSDTTMNHLMLHKLGIKTFYGQSFLADICELDKEMLAYSLHYFKELIETGRIS
                     EIRPSDVWYEERTDFSPTALGTPRVSHTNTGFDLLQGSAQFEGKILGGCLESLYDIFD
                     NSRYADSTELCQKYKLFPDLSDWEGKILLLETSEEKPKPEDFKKMLLTLKDTGIFAVI
                     NGLLVGKPMDETFHDDYKEALLDIIDSNIPIVYNLNVGHATPRAIVPFGVHAHVDAQE
                     QVILFDYNK"
     gene            complement(76774..77457)
                     /locus_tag="ACL8AS_000083"
     CDS             complement(76774..77457)
                     /locus_tag="ACL8AS_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1129 domain-containing protein"
                     /protein_id="HGS1228027.1"
                     /translation="MSQIDLQKLTKKNQEFVHIATQQFIKDGKTDAEIQTIFEEVIPQ
                     ILEEQSKGTTARSLYGAPTHWAHSFTVKEQYEKEHPKENDDPKLMIMDSALFITSLFA
                     LVSALTTFFAADQAFGYGLITLLLVGLVGGFAFYLMYYFVYQYYGPNMDRSQRPPFWK
                     SVLVILASMFLWLLVFFATSFLPASLNPVLDPLPLAIIGAALLALRFYLKKRLNIRSA
                     SAGPTRYQE"
     gene            complement(77469..78413)
                     /locus_tag="ACL8AS_000084"
     CDS             complement(77469..78413)
                     /locus_tag="ACL8AS_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HGS1228028.1"
                     /translation="MKQVFLSTTTEFKEIDTLEPGTWINLVNPTQNESLEIANTFDID
                     IADLRAPLDAEEMSRITIEDEYTLIIVDVPVTEERNNRTYYVTIPLGIIITEETIITT
                     CLEPLPVLDVFINRRLRNFYTFMRSRFIFQILYRNAELYLTALRSIDRKSEQIESQLH
                     QSTRNEELIELMELEKTIVYFKASLKTNERVIKKLTSSTSNIKKYLEDEDLLEDTLIE
                     TQQAIEMADIYGNVLHSMTETFASIISNNQNNIMKTLALVTIVMSIPTMVFSAYGMNF
                     KDNEIPLNGEPNAFWLIVFIAFAMSVSLTLYLIHKKWF"
     gene            78545..81376
                     /gene="uvrA"
                     /locus_tag="ACL8AS_000085"
     CDS             78545..81376
                     /gene="uvrA"
                     /locus_tag="ACL8AS_000085"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HGS1228029.1"
                     /translation="MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFD
                     TLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTT
                     TEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK
                     GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRL
                     FDSIEAALRIAEGYVIIDTMDDSELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCS
                     ECDGLGIKLEVDTDLVVPDASKTLHEGALAPWNPISSNYYPNMLEQAMKVFGVAMDKP
                     FEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYT
                     RTQMRLYMNELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTL
                     SENEAIIARPILKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLS
                     GVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLIDVGPGA
                     GVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVTGARENNL
                     QNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHV
                     DRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRC
                     EACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVE
                     FFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYIL
                     DEPTTGLHTEDIARLLKVLARFVDDGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGT
                     IIVTGTPEEVAANEASYTGHYLKGKLHHE"
     gene            81369..82430
                     /locus_tag="ACL8AS_000086"
     CDS             81369..82430
                     /locus_tag="ACL8AS_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M24 family metallopeptidase"
                     /protein_id="HGS1228030.1"
                     /translation="MNKRVQAFLAKMQEKELDGIIINNLKNVYYLTGFWGSNGTVFIS
                     RDRQVLVTDSRYIIAAKQETSGFEIVADRDELAVIAGIVKDMNLTRIGFEDEISVSYY
                     HRMQAAFAGLNLLPQTQFVEGLRMIKDEAEIAAIRKACSISDQAFRDALDFIKPGKTE
                     IEIANFLDFRMRELGASGLSFDTILASGINSSKPHAHPMHKPVELGEAITMDFGCLYD
                     HYVSDMTRTIYLGHVSDEQAEIYNTVLKANQALIDQAKAGLGFRDFDKIPRDIIIEAG
                     YGDYFTHGIGHGIGLDIHEEPYFSQTSTETIKTGMALTDEPGIYIEGKYGVRIEDDIL
                     ITETGCELLTLAPKELIVI"
     gene            82562..82960
                     /gene="spx"
                     /locus_tag="ACL8AS_000087"
     CDS             82562..82960
                     /gene="spx"
                     /locus_tag="ACL8AS_000087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Spx"
                     /protein_id="HGS1228031.1"
                     /translation="MIKIYTVSSCTSCKKAKTWLNAHQLSYKEQNLGKEGITREELLD
                     ILTKTDNGIASIVSSKNRYAKALGVDIEDLSVNEVLNLIMETPRILKSPILVDEKRLQ
                     VGYKEDDIRAFLPRSVRNVENAEARLRAAL"
     gene            83026..83595
                     /locus_tag="ACL8AS_000088"
     CDS             83026..83595
                     /locus_tag="ACL8AS_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP0191 family lipoprotein"
                     /protein_id="HGS1228032.1"
                     /translation="MKKIVLVSLAFLFVLVGCGQKKETGPATKTEKDTLQSALPVIEN
                     AEKNTVVTKTLVLPKSDDGSQQTQTITYKDKTFLSLAIQQKRPVSDELKTYIDQHGVE
                     ETQKALLEAEEKDKSIIEARKLAGFKLETKLLSATELQTTTSFDFQVLDVKKASQLEH
                     LKNIGLENLLKNEPSKYISDRLANGATEQ"
     gene            83682..83948
                     /locus_tag="ACL8AS_000089"
     CDS             83682..83948
                     /locus_tag="ACL8AS_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HGS1228033.1"
                     /translation="MGFTEETVRFKLDDSNKKEISETLTDVYASLNDKGYNPINQIVG
                     YVLSGDPAYVPRYNNARNQIRKYERDEIVEELVRYYLKGQGVDL"
     gene            83952..84371
                     /gene="ruvX"
                     /locus_tag="ACL8AS_000090"
     CDS             83952..84371
                     /gene="ruvX"
                     /locus_tag="ACL8AS_000090"
                     /EC_number="3.1.21.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003090938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HGS1228034.1"
                     /translation="MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIQINEEQGQFGFDR
                     VKELVDTYKVERFVVGLPKNMNNTSGPRVEASQAYGAKLEEFFGLPVDYQDERLTTVA
                     AERMLIEQADISRNKRKKVIDKLAAQLILQNYLDRKF"
     gene            84387..84692
                     /locus_tag="ACL8AS_000091"
     CDS             84387..84692
                     /locus_tag="ACL8AS_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HGS1228035.1"
                     /translation="MSHDHNHDHEERELITLVDEQGNETLFEILLTIDGKEEFGKNYV
                     LLVPVNAEEDEDGQVEIQAYSFIENEDGTEGELQPIPEDSEDEWNMIEEVFNSFMEE"
     gene            85152..86402
                     /locus_tag="ACL8AS_000092"
     CDS             85152..86402
                     /locus_tag="ACL8AS_000092"
                     /EC_number="6.3.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000464354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="HGS1228036.1"
                     /translation="MFEVEEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTG
                     TNGKGSTIAFMRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLTDQVKE
                     MEKTLLQTPAQLSFFELLTLVAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVIT
                     SIGLDHQETLGDSLEAIAEQKAGIFKAGKKAVIAKLPPEARLVCQKKAESLAVDLYQA
                     GQDFSVLNGDFSSSLLNLSQLNIGLEGAYQQENAALALQTFLLFMGERKEAIDEQAVR
                     KALEQTHWAGRLERIRPQIYLDGAHNLPALTRLVEFIKEKEQEGYRPQILFGSLKRKD
                     YQGMLGYLTENLPQVELKMTGFDYQGSLDETDVTGYHVIPSYREFISSFEERADAQDL
                     LFVTGSLYFISEVRGYLLDREQIN"
     gene            86486..86944
                     /locus_tag="ACL8AS_000093"
     CDS             86486..86944
                     /locus_tag="ACL8AS_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0198 family lipoprotein"
                     /protein_id="HGS1228037.1"
                     /translation="MKLKRFTLSLASLASFSLLVACSQRAQQVQQPVAQQQVQQPAQQ
                     NTNTANAGGNQNQAAPVQNQPVAQPTDIDGTYTGQDDGDRITLVVTGTTGTWTELESD
                     GDQKVKQVTFDSANQRMIIGDDVKIYTVNGNQIVVDDMDRDPSDQIVLTK"
     gene            87090..88622
                     /gene="cls"
                     /locus_tag="ACL8AS_000094"
     CDS             87090..88622
                     /gene="cls"
                     /locus_tag="ACL8AS_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000877342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008808 - cardiolipin synthase activity
                     [Evidence IEA];
                     GO_function: GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA];
                     GO_process: GO:0032049 - cardiolipin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HGS1228038.1"
                     /translation="MKYRKFQLLMSKYGFSLSIMLLELCLVFGLFLYLGRMAPILWIT
                     VLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKK
                     LGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWK
                     KMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTG
                     DYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHV
                     ERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPY
                     GSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRII
                     TPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYR
                     SLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAP
                     IL"
     gene            88880..90418
                     /locus_tag="ACL8AS_000095"
     CDS             88880..90418
                     /locus_tag="ACL8AS_000095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HGS1228039.1"
                     /translation="MSVYGRVEEVHKENREPLEYQIEQESHHRESSRLPLVKILLWST
                     LVTGITLGVPLLLDLMSAQEVQDFYAGWALHQTGKIYSDYYGSQGLLYYLLTYVSQGG
                     FFFAIFEWLALVAGGFFLFRSADTLTNQGDQAGQLVTIFYMLVTGLAFGGGYATLLAL
                     PFLFAAFSLVAAYLSNPSHDKGFVRIGLALAGGFFFAPLSSLLFIAVVSLGLLVFNLG
                     HRRFAHGFYQFLAVALGFSLVFYPTAYYSAATGSFGDAISGIRYPIDSIRFDFTSKIL
                     ENMFFYGLLSLGLGFVVCIFLGLFQSKPFKLYVISVPASLVVILGLILLFFSQEPLHA
                     SYLMVVFPVFLLLLVTNIKSQQRGRSARRSRRETPVSLWSRFFKGNLYLLVFGFVYLL
                     SVPFLMKFVLYPVPYQERNRLADLVKEETNTEDAIYAWDDTATLYRKSERLSPSAILS
                     PLHYTATEENRNKLLNDLKEKQPKVIVVNDKVEVWSEVETLLKENYQQVKTDYSEFKV
                     YKIK"
     gene            90538..92745
                     /gene="nrdD"
                     /locus_tag="ACL8AS_000096"
     CDS             90538..92745
                     /gene="nrdD"
                     /locus_tag="ACL8AS_000096"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004239081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008998 - ribonucleoside-triphosphate
                     reductase (thioredoxin) activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase"
                     /protein_id="HGS1228040.1"
                     /translation="MIALEEKITILPTLFVEKRDGRRVVFDVDKIDKALHKAADKVMD
                     VTPLVEKRLNDLTERIITEIHSRFPQGIKIYEIQNIVEHELLEAKEYALAEEYITYRT
                     QRDFERSKATDINFSIHKLLNKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLQML
                     PKHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLENGFKIGNAEVESPKSIQTA
                     TAQISQIIANVASSQYGGCSADRIDEILAPYAEKNYQKHLKDAEEWVLPEKREDYAWK
                     KTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSRFEREIQKAILNIRIKGLG
                     SEHRTAIFPKLIFTLKRGLNLEEGTPNYDIKQLALECATKRMYPDVLSYDKIVDLTGS
                     FKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESEGDMNKFWEIFNERM
                     NIAEDALVYRVERTKEATPANAPILYQYGAFGHRLGKEESVDQLFKNRRATVSLGYIG
                     LYEVATVFFGNSWESNPDAKEFTLDIIHDMKRRVEEWSDQYGYHFSIYSTPSESLTDR
                     FCRLDIDKFGSIPDITDKEYYTNSFHYDVRKNPTPFEKLDFEKVYPEAGASGGFIHYC
                     EYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDRCYKCDFEGDFEPTERGFACPNCGN
                     SDPKTVDVVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIKIAGHQVTN"
     gene            92757..92897
                     /locus_tag="ACL8AS_000097"
     CDS             92757..92897
                     /locus_tag="ACL8AS_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228041.1"
                     /translation="MGKYQLDDKGRAQVTRYHEKHSKGGAGKKERLLSFREQFLNKNK
                     KK"
     gene            92941..93447
                     /locus_tag="ACL8AS_000098"
     CDS             92941..93447
                     /locus_tag="ACL8AS_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228042.1"
                     /translation="MELRRPRLADKKAVLDMMTEFEKSQSAHDGGFWDTENFVYEEWL
                     ESNQEQEMGINLPEGWVPAIQLVAFSEKGQAVGFLNLRLRLSNFLLEEGGHIGYSIRP
                     SERGKGYAKETLRQGLQVAKEKNIKKALVTCSVNNPASRAVILANGGIFEDAHNGVER
                     YWIEVANE"
     gene            93440..94030
                     /gene="nrdG"
                     /locus_tag="ACL8AS_000099"
     CDS             93440..94030
                     /gene="nrdG"
                     /locus_tag="ACL8AS_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001064213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HGS1228043.1"
                     /translation="MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVAGCMF
                     HCEGCYNVATWSFNAGIPYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVK
                     RIRKELSDKDIWSWTGYTWEEMMLETPDKLELLSLIDILVDGRYDRTKRNLMLQFRGS
                     SNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE"
     gene            94027..94644
                     /locus_tag="ACL8AS_000100"
     CDS             94027..94644
                     /locus_tag="ACL8AS_000100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HGS1228044.1"
                     /translation="MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALD
                     STTVNLLETDPYITSGRHLVVPKDAPNQKVTASLPVAHELESLQRDILALQAGMDVLT
                     IEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRLARDTTVR
                     NRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT"
     gene            94910..95218
                     /gene="rpsJ"
                     /locus_tag="ACL8AS_000101"
     CDS             94910..95218
                     /gene="rpsJ"
                     /locus_tag="ACL8AS_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HGS1228045.1"
                     /translation="MANKKIRIRLKAYEHRTLDTAAAKIVESATRTGAQVAGPIPLPT
                     ERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL
                     "
     gene            95434..96060
                     /gene="rplC"
                     /locus_tag="ACL8AS_000102"
     CDS             95434..96060
                     /gene="rplC"
                     /locus_tag="ACL8AS_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HGS1228046.1"
                     /translation="MTKGILGKKVGMTQIFTEAGELIPVTVIEATPNVVLQVKTVETD
                     GYNAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNVEGLEVGAEITVETFAA
                     GDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAG
                     RMGGDRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK"
     gene            96085..96708
                     /gene="rplD"
                     /locus_tag="ACL8AS_000103"
     CDS             96085..96708
                     /gene="rplD"
                     /locus_tag="ACL8AS_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HGS1228047.1"
                     /translation="MANVTLFDQTGKEAGQVVLNDAVFGIEPNESVVFDVIISQRASL
                     RQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLP
                     QKVRRLALKSVYSEKVAENKFVAVDALSFTAPKTAEFAKVLAALSIDSKVLVILEEGN
                     EFAALSARNLPNVKVATATTASVLDIANSDKLLVTQAAISKIEEVLA"
     gene            96708..97004
                     /locus_tag="ACL8AS_000104"
     CDS             96708..97004
                     /locus_tag="ACL8AS_000104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HGS1228048.1"
                     /translation="MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEA
                     AFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE"
     gene            97022..97855
                     /gene="rplB"
                     /locus_tag="ACL8AS_000105"
     CDS             97022..97855
                     /gene="rplB"
                     /locus_tag="ACL8AS_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019790357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HGS1228049.1"
                     /translation="MGIRVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRN
                     NNGRITVRHQGGGHKRFYRLVDFKRNKDNVEAVVKTIEYDPNRSANIALVHYTDGVKA
                     YIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTLIHNIELKPGRGGELVRAAGA
                     SAQVLGSEGKYVLVRLQSGEVRMILGTCRATVGVVGNEQHGLVNLGKAGRSRWKGIRP
                     TVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNE
                     K"
     gene            97959..98240
                     /gene="rpsS"
                     /locus_tag="ACL8AS_000106"
     CDS             97959..98240
                     /gene="rpsS"
                     /locus_tag="ACL8AS_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000533767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HGS1228050.1"
                     /translation="MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSF
                     IGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRRK"
     gene            98252..98596
                     /gene="rplV"
                     /locus_tag="ACL8AS_000107"
     CDS             98252..98596
                     /gene="rplV"
                     /locus_tag="ACL8AS_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HGS1228051.1"
                     /translation="MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTP
                     NKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINK
                     RTAHITVAVAEK"
     gene            98609..99262
                     /gene="rpsC"
                     /locus_tag="ACL8AS_000108"
     CDS             98609..99262
                     /gene="rpsC"
                     /locus_tag="ACL8AS_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HGS1228052.1"
                     /translation="MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQK
                     ELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINI
                     IEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGAD
                     IARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK"
     gene            99266..99679
                     /gene="rplP"
                     /locus_tag="ACL8AS_000109"
     CDS             99266..99679
                     /gene="rplP"
                     /locus_tag="ACL8AS_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003029477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0019843 - rRNA binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HGS1228053.1"
                     /translation="MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEYGLQATTSHWITN
                     RQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKV
                     MFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE"
     gene            99689..99895
                     /gene="rpmC"
                     /locus_tag="ACL8AS_000110"
     CDS             99689..99895
                     /gene="rpmC"
                     /locus_tag="ACL8AS_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HGS1228054.1"
                     /translation="MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAATGQL
                     EQTARLKEVKKQIARIKTVQSEAK"
     gene            99920..100180
                     /gene="rpsQ"
                     /locus_tag="ACL8AS_000111"
     CDS             99920..100180
                     /gene="rpsQ"
                     /locus_tag="ACL8AS_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HGS1228055.1"
                     /translation="MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKK
                     YKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII"
     gene            100206..100574
                     /gene="rplN"
                     /locus_tag="ACL8AS_000112"
     CDS             100206..100574
                     /gene="rplN"
                     /locus_tag="ACL8AS_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012727667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HGS1228056.1"
                     /translation="MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVK
                     QATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPV
                     ARELREGGFMKIVSLAPEVL"
     gene            100652..100957
                     /gene="rplX"
                     /locus_tag="ACL8AS_000113"
     CDS             100652..100957
                     /gene="rplX"
                     /locus_tag="ACL8AS_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HGS1228057.1"
                     /translation="MFVKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKH
                     QRPTNELPQGGIIEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD"
     gene            100981..101523
                     /gene="rplE"
                     /locus_tag="ACL8AS_000114"
     CDS             100981..101523
                     /gene="rplE"
                     /locus_tag="ACL8AS_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HGS1228058.1"
                     /translation="MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEA
                     VSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLD
                     KLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTT
                     ANTDEESRALLTGLGMPFAK"
     gene            101541..101810
                     /gene="rpsN"
                     /locus_tag="ACL8AS_000115"
     CDS             101541..101810
                     /gene="rpsN"
                     /locus_tag="ACL8AS_000115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S14"
                     /protein_id="HGS1228059.1"
                     /translation="MAKKSMVAREAKRQKIVDRYAEKRAALKAAGDYEGLSKLPRNAS
                     PTRLHNRCRVTGRPHSVYRKFGLSRIAFRELAHKGQIPGVTKASW"
     gene            102095..102493
                     /gene="rpsH"
                     /locus_tag="ACL8AS_000116"
     CDS             102095..102493
                     /gene="rpsH"
                     /locus_tag="ACL8AS_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009754342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HGS1228060.1"
                     /translation="MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREG
                     FVKNVEIIEDDKQGVIRVFLKYGSNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLG
                     IAILSTSEGLLTDKEARQKNVGGEVIAYVW"
     gene            102685..103221
                     /gene="rplF"
                     /locus_tag="ACL8AS_000117"
     CDS             102685..103221
                     /gene="rplF"
                     /locus_tag="ACL8AS_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0019843 - rRNA binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HGS1228061.1"
                     /translation="MSRIGNKVIVLPAGVELANNDNVVTVKGPKGELTREFSKDIEIR
                     VEGTEITLHRPNDSKEMKTIHGTTRALLNNMVVGVSEGFKKELEMRGVGYRAQLQGSK
                     LVLAVGKSHPDEVEAPEGITFELPNPTTIVVSGISKEVVGQTAAYVRSLRSPEPYKGK
                     GIRYVGEFVRRKEGKTGK"
     gene            103305..103661
                     /gene="rplR"
                     /locus_tag="ACL8AS_000118"
     CDS             103305..103661
                     /gene="rplR"
                     /locus_tag="ACL8AS_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HGS1228062.1"
                     /translation="MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQV
                     IDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHG
                     RVKALADAARENGLKF"
     gene            103679..104173
                     /gene="rpsE"
                     /locus_tag="ACL8AS_000119"
     CDS             103679..104173
                     /gene="rpsE"
                     /locus_tag="ACL8AS_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HGS1228063.1"
                     /translation="MAFKDNAVELEERVVAVNRVTKVVKGGRRLRFAALVVVGDHNGR
                     VGFGTGKAQEVPEAIRKAVDDAKKNLIEVPMVGTTIPHEVLSEFGGAKVLLKPAVEGS
                     GVAAGGAVRAVVELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEIAALRGISV
                     SDLA"
     gene            104187..104369
                     /gene="rpmD"
                     /locus_tag="ACL8AS_000120"
     CDS             104187..104369
                     /gene="rpmD"
                     /locus_tag="ACL8AS_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HGS1228064.1"
                     /translation="MAQIKITLTKSPIGRIPSQRKTVVALGLGKLNSSVIKEDNAAIR
                     GMITAVSHLVTVEEVN"
     gene            104514..104954
                     /gene="rplO"
                     /locus_tag="ACL8AS_000121"
     CDS             104514..104954
                     /gene="rplO"
                     /locus_tag="ACL8AS_000121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HGS1228065.1"
                     /translation="MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGG
                     GVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIV
                     KAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI"
     gene            104967..106277
                     /gene="secY"
                     /locus_tag="ACL8AS_000122"
     CDS             104967..106277
                     /gene="secY"
                     /locus_tag="ACL8AS_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0015031 - protein transport [Evidence IEA];
                     GO_process: GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HGS1228066.1"
                     /translation="MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANS
                     LNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASIVVQLLQMDILPKFVEWGKQ
                     GEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTA
                     GSMIVTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSII
                     FVIILIITVLLIIYFTTYVQQAEYKIPIQYTKVAQGAPSSSYLPLKINPAGVIPVIFA
                     SSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTFVQI
                     NPEKAAESLQKSGAYIHGVRPGKGTEEYMSKLLRRLATVGSLFLGVISILPIAAKDVF
                     GLSDVVAFGGTSLLIIISTGIEGIKQLEGYLLKRKYVGFMDRTE"
     gene            106428..107066
                     /locus_tag="ACL8AS_000123"
     CDS             106428..107066
                     /locus_tag="ACL8AS_000123"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HGS1228067.1"
                     /translation="MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTE
                     MGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLA
                     ELGIELEGVINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
                     PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK"
     gene            107183..107401
                     /gene="infA"
                     /locus_tag="ACL8AS_000124"
     CDS             107183..107401
                     /gene="infA"
                     /locus_tag="ACL8AS_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003743 - translation initiation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HGS1228068.1"
                     /translation="MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNY
                     IRILAGDRVTVEMSPYDLTRGRITYRFK"
     gene            107426..107542
                     /gene="rpmJ"
                     /locus_tag="ACL8AS_000125"
     CDS             107426..107542
                     /gene="rpmJ"
                     /locus_tag="ACL8AS_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013773089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HGS1228069.1"
                     /translation="MKVRPSVKPICEYCKVIRRNGRVMVICPANPKHKQRQG"
     gene            107560..107925
                     /gene="rpsM"
                     /locus_tag="ACL8AS_000126"
     CDS             107560..107925
                     /gene="rpsM"
                     /locus_tag="ACL8AS_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HGS1228070.1"
                     /translation="MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVR
                     VRDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNT
                     KNNARTRKGKAVAIAGKKK"
     gene            107943..108326
                     /gene="rpsK"
                     /locus_tag="ACL8AS_000127"
     CDS             107943..108326
                     /gene="rpsK"
                     /locus_tag="ACL8AS_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HGS1228071.1"
                     /translation="MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSS
                     AGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAG
                     LEVTAIRDVTPVPHNGARPPKRRRV"
     gene            108369..109304
                     /locus_tag="ACL8AS_000128"
     CDS             108369..109304
                     /locus_tag="ACL8AS_000128"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HGS1228072.1"
                     /translation="MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLA
                     SLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGP
                     AEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVG
                     TLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEH
                     LDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLT
                     EKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK"
     gene            109316..109702
                     /gene="rplQ"
                     /locus_tag="ACL8AS_000129"
     CDS             109316..109702
                     /gene="rplQ"
                     /locus_tag="ACL8AS_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HGS1228073.1"
                     /translation="MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTV
                     EKMITLGKRGDLHARRQAAALVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAER
                     NGGYTRILKTEPRRGDAAPMAIIELV"
     gene            109967..110233
                     /locus_tag="ACL8AS_000130"
     CDS             109967..110233
                     /locus_tag="ACL8AS_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002905356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HGS1228074.1"
                     /translation="MKAIITVVGKDKSGIVAGVSGKIAELGLNIDDISQTVLDEYFTM
                     MAIVSSDEKQDFTYLRNEFEAFGQTLNVKINIQSAAIFEAMYNI"
     gene            110243..111580
                     /locus_tag="ACL8AS_000131"
     CDS             110243..111580
                     /locus_tag="ACL8AS_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HGS1228075.1"
                     /translation="MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPDINRAAEKI
                     YQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIGAATDATDYVVLAKALDKA
                     AKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTA
                     VADMGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGV
                     VKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPA
                     VGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDE
                     GMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKT
                     TAVRIIPKGKEGDMIEFGGLLGTAPVMRVNGASSVDFISRGGQIPAPIHSFKN"
     gene            111824..112516
                     /locus_tag="ACL8AS_000132"
     CDS             111824..112516
                     /locus_tag="ACL8AS_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HGS1228076.1"
                     /translation="MVKVRLYLVRHGKTMFNTIGRAQGWSDTPLTAEGERGIQELGIG
                     LRESDLQFERAYSSDSGRTIQTMGIILEELGLQGKIPYRMDKRIREWCFGSFDGAYDG
                     DLFMGIIPRIFNVDHVHQLSYAELAEGLVEVDTAGWAEGWEKLSGRIKEGFEMIAKEM
                     EDQGGGNALVVSHGMTIGTIVYLINGMHPHGLDNGSVTILEYEDGQFRVEVVGDRSYR
                     ELGREKMEEGSI"
     gene            complement(112619..114254)
                     /locus_tag="ACL8AS_000133"
                     /pseudo
     CDS             complement(112619..114254)
                     /locus_tag="ACL8AS_000133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520796.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(114244..115335)
                     /locus_tag="ACL8AS_000134"
     CDS             complement(114244..115335)
                     /locus_tag="ACL8AS_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001289361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228077.1"
                     /translation="MSEIEIINAKKIYHDVPVIENLNITIPKGSLFTLLGASGCGKTT
                     LLRMIAGFNSIKDGEFYFDDTKINNMEPSKRNIGLVFQNYAIFPHLTVRDNVAFGLMQ
                     KKVPKEELIQQTNKYLELMQIAQYADRKPDKLSGGQQQRVTLACALAVNPSVLLMDEP
                     LSNLEAKLRLDMRQAIREIQHEVGITTVYVTHDQEEAMAISDQIAVMKDGVIQQIGRP
                     KELYHKPANEFVATFIGRTNIIPTNLEKRSDGAYIVFSDGYALRMPVLDQVEEQAIHV
                     SIRPEEFIKDESGDIEGTISDSVYLGLNTEYFIETGFASKIQVSEESTFEEDLQKGNR
                     IRLRINTQKLNIFSADGSQNLIKGVNHGT"
     gene            complement(115348..116469)
                     /locus_tag="ACL8AS_000135"
                     /pseudo
     CDS             complement(115348..116469)
                     /locus_tag="ACL8AS_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085230.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
     gene            complement(116686..116910)
                     /locus_tag="ACL8AS_000136"
                     /pseudo
     CDS             complement(116686..116910)
                     /locus_tag="ACL8AS_000136"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
     gene            complement(116958..117734)
                     /locus_tag="ACL8AS_000137"
     CDS             complement(116958..117734)
                     /locus_tag="ACL8AS_000137"
                     /EC_number="1.97.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000406168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0043687 - post-translational protein
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HGS1228078.1"
                     /translation="MEISKGIIFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCSNPESQ
                     RMKPEKMKDAQREKFTLVGEEKTVEEIITEVLKDKEFYEESGGGLTLSGGEIFAQFEF
                     AKAILKSAKEHHIHTAIETTAFVDHEKFIDLIQYVDFIYTDLKHYNSIKHKKVTGVFN
                     QMIIKNIHYAFSQNKTIVLRIPVIPNFNNSLEDAEKFATLFNSLNIDQVQLLPFHQFG
                     ENKYRLLNRKYEMDGVNALHPEDLIDYQKVFLNHHINCYF"
     gene            117856..118602
                     /locus_tag="ACL8AS_000138"
     CDS             117856..118602
                     /locus_tag="ACL8AS_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000824973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HGS1228079.1"
                     /translation="MKRLEQIIKLVSEYEKIDVNTLSEKLNVSKVTIRKDLDKLESKG
                     LLHREHGYAVLNSGDDLNVRLSINYEIKRKIVQEAVKLVSDNETIMIESGSTCALLAE
                     EICKQKRNVTIVTNSFFIANFVRAYDSCRIIVLGGEFQKDSQVTVGPLLKEMIQTFHV
                     HQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAASDKVIVLTDSSKFDKRGTVRRFALS
                     QVYEVITDEKLSKQNIATLENAGIMVKVVS"
     gene            118615..119595
                     /locus_tag="ACL8AS_000139"
     CDS             118615..119595
                     /locus_tag="ACL8AS_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding domain-containing protein"
                     /protein_id="HGS1228080.1"
                     /translation="MNQDRNKLLSKIAYLYYIENLNQSQIAAKLGIYRTSISRMLTEA
                     RNVGIVKIEIENFDTNMFKLENYVKEKYSLESLEIIPNEFDDTPTILSERISQVAAGV
                     LRNLIDDNMKIGFSWGKSLSNLVDLIHSKSVRNVHFYPLAGGPSHIHAKYHVNTLIYE
                     MSRKFHGECTFMNATIVQENKLLADGILQSRYFENLKNSWKDLDIAVVGIGDFSNKGK
                     HQWLDMLTEDDFKELTKVKTVGEICCRFFDSKGKEVYENLQERTIAISLEDLKNIPQS
                     LAVAYGDTKVSSILSVLRANLVNHLITDKNTILKVLEEDGDLTFREILGE"
     gene            119790..120110
                     /locus_tag="ACL8AS_000140"
     CDS             119790..120110
                     /locus_tag="ACL8AS_000140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HGS1228081.1"
                     /translation="MEIIVPDQIIMGLILYAGDAKQHIYKALDYIKNGTCERCEEEIQ
                     LADAALLEAHNLQTKFLAQEASGTKTEITALFVHSQDHLMTSMTEINLIKEIISLRKE
                     LHKK"
     gene            120156..120464
                     /locus_tag="ACL8AS_000141"
     CDS             120156..120464
                     /locus_tag="ACL8AS_000141"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1228082.1"
                     /translation="MVKIGLFCAAGFSTGMLVNNMKIAAQASGVEAEIEAFSQSKLAD
                     YAPNIDVALLGPQVAYTLDKSKEICDKCDVPIAVIPMMDYGMLDGKKVLDLALSLISG
                     "
     gene            120481..121779
                     /locus_tag="ACL8AS_000142"
     CDS             120481..121779
                     /locus_tag="ACL8AS_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HGS1228083.1"
                     /translation="MSKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLI
                     MGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAIMGLISCFSIAYSYAKNSGVEALP
                     AGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIK
                     RKIVIKMPEQVPQAIAKQFEAMIPAFVIFLSSMIVYILAKSMTNGGTFIEMIYSAIQV
                     PLQGLTGSLYGAIGIAFFISFLWWFGVHGQSVVNGVVTALLLSNLDANKAMLASGNLS
                     LENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFVAKSKQYQALGKVAAFPAIFNVNE
                     PVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFL
                     VGGWQGVVTQLLVLAMSTMVYFPFFKIQDRLAYQNEIKQS"
     gene            121930..124368
                     /locus_tag="ACL8AS_000143"
     CDS             121930..124368
                     /locus_tag="ACL8AS_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HGS1228084.1"
                     /translation="MVNTEVARTTIKTEYFGSLTERMNKYREDVLNKKPYIDAERAVL
                     ATRAYERYKEQPNVLKRAYMLKEILENMTIYIEEESMIAGNQASSNKDAPIFPEYTLE
                     FVLNELDLFEKRDGDVFYITEETKEQLRSIAPFWENNNLRARAGALLPEEVSVYMETG
                     FFGMEGKMNSGDAHLAVNYQKLLQFGLRGFEERARKAKVALDLTDPASIDKYHFYDSI
                     FIVIDAIKVYAKRFVALAKSLAENANPKRKKELLEIADICSRVPYEPATTFAEAIQSV
                     WFIQCILQIESNGHSLSYGRFDQYMYPYMKADLESGKETEDSIVERLTNLWIKTITIN
                     KVRSQSHTFSSAGSPLYQNVTIGGQTRDKKDAVNPLSYLVLKSVAQTHLPQPNLTVRY
                     HAGLDARFMNECIEVMKLGFGMPAFNNDEIIIPSFIAKGVLEDDAYDYSAIGCVETAV
                     PGKWGYRCTGMSYMNFPKVLLITMNDGIDPASGKRFAPSFGHFKDMKNFSELENAWDK
                     TLRYLTRMSVIVENSIDLSLEREVPDILCSALTDDCIGRGKHLKEGGAVYDYISGLQV
                     GIANLSDSLAAIKKLVFEEERISPSQLWHALETDYAGEEGKVIQEMLIHDAPKYGNDD
                     DYADKLVTAAYDIYVDEIAKYPNTRYGRGPIGGIRYSGTSSISANVGQGRGTLATPDG
                     RNAGTPLAEGCSPSHNMDQHGPTSVLKSVSKLPTDEIVGGVLLNQKVNPQTLAKEEDK
                     LKLIALLRTFFNRLHGYHIQYNVVSRETLIDAQKHPEKHRDLIVRVAGYSAFFNVLSK
                     ATQDDIIGRTEHTL"
     gene            124387..125055
                     /locus_tag="ACL8AS_000144"
     CDS             124387..125055
                     /locus_tag="ACL8AS_000144"
                     /EC_number="4.1.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HGS1228085.1"
                     /translation="MEFMLDTLNLDEIKKWSEILPLAGVTSNPTIAKREGSINFFERI
                     KDVRELIGSTPSIHVQVISQDFEGILKDAHEIRRQAGDDIFIKVPVTPAGLRAIKVLK
                     KEGYHITATAIYTVIQGLLAIEVGADYLAPYYNRMENLNIDSNSVIRQLALAVDRQNS
                     PSKILAASFKNVAQVNNALAAGAHAVTAGADVFESAFAMPSIQKAVDDFSDDWFVIQN
                     SRSI"
     gene            125073..126161
                     /locus_tag="ACL8AS_000145"
     CDS             125073..126161
                     /locus_tag="ACL8AS_000145"
                     /EC_number="1.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0008888 - glycerol dehydrogenase (NAD+)
                     activity [Evidence IEA];
                     GO_function: GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol dehydrogenase"
                     /protein_id="HGS1228086.1"
                     /translation="MRIFASPSRYIQGENALFENAKSILDLGNYPILLCDQLVYDIVG
                     KRFEDYLHRYGFHIVLALFNGEASDNEINRVVALAEKENCDSIIGLGGGKTIDSAKAI
                     ADLIEKPVIIAPTIASTDAPVSALSVIYTDEGAFDHYLFYSKNPDLVLVDTKVISQAP
                     KRLLASGIADGLATWVEARAVMQANGKTMLGQQQTLAGVAIAKKCEETLFADGLQAMA
                     ACEAKVVTPALENIVEANTLLSGLGFESGGLAAAHAIHNGFTALTGDIHHLTHGEKVA
                     YGTLVQLLLENRPKEELDKYIEFYKKIGMPTTLKEMHLDQVGYDDLIKVGKQATMEGE
                     TIHQMPFKISPSDVAQAIIAVDAYVNSK"
     gene            126616..129117
                     /gene="leuS"
                     /locus_tag="ACL8AS_000146"
     CDS             126616..129117
                     /gene="leuS"
                     /locus_tag="ACL8AS_000146"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004823 - leucine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006429 - leucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HGS1228087.1"
                     /translation="MSFYNHKEIEPKWQGYWAEHHTFKTGTDASKPKFYALDMFPYPS
                     GAGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTA
                     ENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
                     ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWPESIKD
                     MQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHELVDAITSSEQ
                     AEAVANYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGT
                     GAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVAEAAYTEDGLHVNSDFLDGLNKEEA
                     IAKIVAWLEEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLV
                     LPVTKDIRPSGTGESPLANLTDWLEVTRADGVKGRRETNTMPQWAGSSWYYLRYIDPH
                     NTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFN
                     QGMILGTSYRDHRGALVTTDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDV
                     VEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEILAENNGALD
                     KAYNETVKAVTEQIESLKFNTAIAQLMVFVNAANKEDKLYVDYAKGFIQLIAPFAPHL
                     AEELWQTVAETGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREEL
                     QEIALADEKVKAEIDGKEIVKVISVPNKLVNIVVK"
     gene            129311..130006
                     /locus_tag="ACL8AS_000147"
     CDS             129311..130006
                     /locus_tag="ACL8AS_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001144916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family protein"
                     /protein_id="HGS1228088.1"
                     /translation="MPVNEYGQMIGESMEGYTPGELPSIDFLEGRYARIEALSVEKHA
                     EDLLAVYGPDTPQEMWTYLFQEPVADMGELVSLLHQMLARKDRFYYAIIDKATGKALG
                     SFSLMRIDQNNRVIEVGAVTFSPELRGTRIGTEAQYLLARYVFEELNYRRYEWKCDAL
                     NLPSRRAAERLSFIYEGTFRQAVVYKGRTRDTDWLSMIDKDWPQVKDRLETWLRPENF
                     DKNGQQYKSLREL"
     gene            130018..130434
                     /locus_tag="ACL8AS_000148"
     CDS             130018..130434
                     /locus_tag="ACL8AS_000148"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228089.1"
                     /translation="MITIKKQEIVKLEDVLHLYQAVGWTNYTHQTEMLEQALSHSLVI
                     YLALDGDAVVGLIRLVGDGFSSVFVQDLIVLSSYQRQGIGSSLMKQALGNFKEAYQVQ
                     LATEQTEKNVGFNRSMGFEILSTYNWIGMTWMNRKK"
     gene            complement(131249..131341)
                     /locus_tag="ACL8AS_000149"
     CDS             complement(131249..131341)
                     /locus_tag="ACL8AS_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="HGS1228090.1"
                     /translation="MMELVLKTIIGPIVVGVVLRIVDKWLNKDK"
     gene            131475..132473
                     /gene="ruvB"
                     /locus_tag="ACL8AS_000150"
     CDS             131475..132473
                     /gene="ruvB"
                     /locus_tag="ACL8AS_000150"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0009378 - four-way junction helicase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HGS1228091.1"
                     /translation="MSRILDNEMMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEA
                     AKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELE
                     PGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTR
                     AGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPR
                     IANRLLKRVRDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGG
                     PVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK"
     gene            132454..133026
                     /locus_tag="ACL8AS_000151"
     CDS             132454..133026
                     /locus_tag="ACL8AS_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001098890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase family protein"
                     /protein_id="HGS1228092.1"
                     /translation="MNTVKNKQEILEAFRENPDMMAILTIIRDLGLKDSWLAAGSVRN
                     FIWNLLSDKSPFDFETDVDVIFFDPDISYEETLLLEKKLREDFPQYQWELKNQVYMHQ
                     HSPHTAFYTSSRDAMSKYPERCTAVGLRLNEESDFELYVPYGLEDILNFQVRPTPHFL
                     ENEDRMELYQTRLFKKNWQEKWKNLIFKNT"
     gene            133257..134015
                     /locus_tag="ACL8AS_000152"
     CDS             133257..134015
                     /locus_tag="ACL8AS_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HGS1228093.1"
                     /translation="MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFG
                     HKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPEL
                     HANNVKIQMIGETDRLPKQTFEALIKAEELTKNNTGLILNFALNYGGRAEITQALKLI
                     SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYS
                     ELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV"
     gene            134024..134827
                     /locus_tag="ACL8AS_000153"
     CDS             134024..134827
                     /locus_tag="ACL8AS_000153"
                     /EC_number="2.7.7.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004605 - phosphatidate
                     cytidylyltransferase activity [Evidence IEA];
                     GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HGS1228094.1"
                     /translation="MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIVAMLAMHE
                     LLKMRGLATMTMEGLLTLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTVFS
                     KSYTIEDAVFPLAMSFYVGFGFNALLDARVAGLDKALLALCIVWATDSGAYLVGMNYG
                     KRKLAPRVSPNKTLEGALGGILGAILVTIIFMIVDSTVALPYGIYKMSVFAIFFSIAG
                     QFGDLLESSIKRHFGVKDSGKFIPGHGGVLDRFDSMLLVFPIMHLFGLF"
     gene            134849..136108
                     /gene="rseP"
                     /locus_tag="ACL8AS_000154"
     CDS             134849..136108
                     /gene="rseP"
                     /locus_tag="ACL8AS_000154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HGS1228095.1"
                     /translation="MLGILTFILVFGIIVVVHEFGHFYFAKKSGILVREFAIGMGPKI
                     FAHIGKDGTAYTIRILPLGGYVRMAGWGDDTTEIKTGTPVSLTLADDGKVKRINLSGK
                     KLDQTALPMQVTQFDFEDKLFIKGLVLEEEKTFAVDHDATVVEADGTEVRIAPLDVQY
                     QNATIWGKLITNFAGPMNNFILGVVVFWVLIFMQGGVRDVDTNQFHIMPQGALAKVGV
                     PETAQITKIGSHEVSNWESLIQAVETETKDKTAPTLDVTISEKGSDKQVTVTPEDSQG
                     RYLLGVQPGVKSDFLSMFVGGFTTAADSALRILSALKNLIFQPDLNKLGGPVAIFKAS
                     SDAAKNGIENILYFLAMISINIGIFNLIPIPALDGGKIVLNILEAIRRKPLKQEIETY
                     VTLAGVVIMVVLMIAVTWNDIMRLFFR"
     gene            136121..137974
                     /locus_tag="ACL8AS_000155"
     CDS             136121..137974
                     /locus_tag="ACL8AS_000155"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0002161 - aminoacyl-tRNA editing activity
                     [Evidence IEA];
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0004827 - proline-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA];
                     GO_process: GO:0006433 - prolyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HGS1228096.1"
                     /translation="MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLP
                     LANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKS
                     DFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDA
                     YSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSART
                     DLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATN
                     EYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVG
                     NDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVR
                     NAVVGANEDGYHLTGVNPGRDFTSEYVDIREVREGEISPDGQGVLNFARGIEIGHIFK
                     LGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRY
                     AWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKF
                     SDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK"
     gene            138073..139452
                     /gene="bglA"
                     /locus_tag="ACL8AS_000156"
     CDS             138073..139452
                     /gene="bglA"
                     /locus_tag="ACL8AS_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000943526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HGS1228097.1"
                     /translation="MLRFPKDFVWGSSTSGPQTEGRVAGDGKGDNLWDYWFQVEPNRY
                     YNGIGSDKTSTFYENWERDIELLLETGHTAFRTSIQWSRIFPQGCGKVNPQGVDFYRK
                     VFEAIKAKGIRLLVNLYHFDLPFALQEDGDGWENKATVSAYEDYARFCFETYGDLVDQ
                     WITFNEPIVPVEFGYFYDAHYPHKVDAEAAVKVAYHTQLASSRAVKACHELLPDSKIG
                     IVLNLTPAYPRSQHPADVKAARIAALFQAQSFLDPSVLGTYPQELVEILHEHGLLPDA
                     TEEELELIRDNTVDFLGVNYYQPLRVMAPRFAKHPESPLLPEHFYEPYVMPGRKINSH
                     RGWEIYEQGIYDIAQNIKENYGNIEWMLTENGMGVEGEEKFRQDGMIQDDYRIDFVKG
                     HLRELHRAIEDGANCKGYLIWTFIDCWSWLNSYKNRYGLVELDLETQERRLKKSGHWF
                     KELSDNNGF"
     gene            139645..141453
                     /gene="glmS"
                     /locus_tag="ACL8AS_000157"
     CDS             139645..141453
                     /gene="glmS"
                     /locus_tag="ACL8AS_000157"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA];
                     GO_process: GO:1901137 - carbohydrate derivative
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HGS1228098.1"
                     /translation="MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHL
                     VKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIE
                     NYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
                     VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADS
                     VEVQDYDGNRRERTSYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQ
                     VVVDPDIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPL
                     LSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGP
                     EIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQVFDLVHELSIVAQSIESTLSEKET
                     IEVKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALI
                     EEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTTVHPYLS
                     PISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE"
     gene            141572..142621
                     /locus_tag="ACL8AS_000158"
     CDS             141572..142621
                     /locus_tag="ACL8AS_000158"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HGS1228099.1"
                     /translation="MVELGISTFGEITELEGTGQTYSHAERIRQLVAEIELADKVGLD
                     VYGIGEHHRADFAVSAPEIVLAAGAVNTKKIRLTSAVSILSSMDPIRLFQQYATIDAL
                     SNGRSEIMAGRGSFTESFPLFGYDLKDYDSLFDEKLDLLQLVNEKTKLDWQGRLTQTI
                     AGKEVYPRPVQDKLPLWIATGGHVESTVKIAQAGLPIVYAIIGGNPRYFKKLIQAYRE
                     IGSEAGHADKDLKVGAHSWGWIAEDGEQAVKDYFHPTKQVVDAISKDRPHWQELRYEQ
                     YLEQVGPNGAMFVGNPDQVAEKLICMIEDLGLDRFMLHLPLGSMPHDQVLRAIELFGT
                     QVAPKVRAYFAMKEA"
     gene            complement(142721..146563)
                     /gene="spuA"
                     /locus_tag="ACL8AS_000159"
     CDS             complement(142721..146563)
                     /gene="spuA"
                     /locus_tag="ACL8AS_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored pullulanase SpuA"
                     /protein_id="HGS1228100.1"
                     /translation="MRKTPSHTEKKMVYSIRSLKNGTGSVLIGTSLVLLAMATPTISS
                     DESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPGNANASLEKTEEKPAASPA
                     DPAPQTGQDRSSEPTTSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDD
                     VEKPSENWPNGALSFKDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVE
                     KLVPKMNEAWLDQDYKVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQW
                     PDGTDFTATGKYGRYIDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQ
                     IFLKDDDESIYTNPYYVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHL
                     GNKVTITDVAIDEAGKKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGK
                     LGADLKEEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDST
                     NKLGITDFTGYYYQYQIERQGKTVLALDPYAKSLAAWNSDDSKIDDAHKVAKAAFVDP
                     AKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDY
                     LKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSD
                     PKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDLFEDLEPNYYHFMDADGTPR
                     TSFGGGRLGTTHHMTKRLLIDSIKYLVDTYKVDGFRFDMMGDHDATSIEEAYKAARAL
                     NPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPA
                     FITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKA
                     ENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHL
                     LRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQS
                     TDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKARE
                     FNLGTAFAHLRNAEVLADENQAGSVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTS
                     HESTAEEKPDSTPSKPEHQNEASHPEHQDPAPEARPDSTKPDTKVADAENKPSQATAD
                     SQAEQPAQEAQASSVKEAVRNESVENSSKKNIPATPDRQAELPNTGIKNENKLLFAGI
                     SLLALLGLGFLLKNKKEN"
     gene            146980..147393
                     /gene="rpsL"
                     /locus_tag="ACL8AS_000160"
     CDS             146980..147393
                     /gene="rpsL"
                     /locus_tag="ACL8AS_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002356190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HGS1228101.1"
                     /translation="MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKR
                     GVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKD
                     LPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA"
     gene            147413..147883
                     /gene="rpsG"
                     /locus_tag="ACL8AS_000161"
     CDS             147413..147883
                     /gene="rpsG"
                     /locus_tag="ACL8AS_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HGS1228102.1"
                     /translation="MSRKNRAPKRDVLPDPLYNSQLVTRLINRVMLDGKRGTAASIVY
                     GAFEQIKEATGNDALEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLR
                     WLVTIARLRGEHTMQDRLAKEILDAANNTGAAVKKREDTHRMAEANRAFAHFRW"
     gene            148308..150389
                     /gene="fusA"
                     /locus_tag="ACL8AS_000162"
     CDS             148308..150389
                     /gene="fusA"
                     /locus_tag="ACL8AS_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HGS1228103.1"
                     /translation="MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETH
                     EGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGA
                     VTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAH
                     PIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLIEAV
                     AETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVID
                     YLPSPLDIPAIKGINPDTDAEEIRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVL
                     QSGSYVLNTSKGKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEK
                     AKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVIS
                     GMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDV
                     WIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLY
                     DGSYHDVDSSETAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTA
                     RRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQ
                     EEIIKKNKGED"
     gene            150493..154884
                     /locus_tag="ACL8AS_000163"
     CDS             150493..154884
                     /locus_tag="ACL8AS_000163"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HGS1228104.1"
                     /translation="MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFH
                     FVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGP
                     CASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQ
                     VEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKA
                     AAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSM
                     QKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPE
                     GERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKA
                     GIQLIYGMEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKM
                     YKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVA
                     HNATFDVGFMNANYERHDLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEH
                     HHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKN
                     QVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVD
                     AAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGN
                     VHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFL
                     GEELARKLVIENTNALAEIFESVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPL
                     PDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGI
                     TEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIPFETFLG
                     FDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERD
                     YGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQ
                     TTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVL
                     GVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQD
                     LIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIE
                     AMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAK
                     AFDIKTMGAGLEVIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLD
                     LYRSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSST
                     LVEKMDEMGILGNMPEDNQLSLFDELF"
     gene            154986..155249
                     /locus_tag="ACL8AS_000164"
     CDS             154986..155249
                     /locus_tag="ACL8AS_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="HGS1228105.1"
                     /translation="MSKMSISIRLDSEVKEQAQQVFSNLGMDMTTAINIFLRQAIQYQ
                     GLPFDVRLDENRKLLQALTDLDQNRNMSQSFESVSDLMEDLRA"
     gene            155242..155520
                     /locus_tag="ACL8AS_000165"
     CDS             155242..155520
                     /locus_tag="ACL8AS_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system YafQ family
                     toxin"
                     /protein_id="HGS1228106.1"
                     /translation="MLKIRYHKQFKKDFKLAMKRGLKAELLEEVLNFLVQEKEHPARY
                     RDHSLTASKHFQGVRECHTQPDWLLVYKVDKSELILNLLRTGSHSDLF"
     gene            155541..155693
                     /locus_tag="ACL8AS_000166"
     CDS             155541..155693
                     /locus_tag="ACL8AS_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228107.1"
                     /translation="MKLRIFAEDKPAKKVFEYQLELADRTILLSTALLSGAIALAGIF
                     SALKEK"
     gene            155715..156956
                     /locus_tag="ACL8AS_000167"
     CDS             155715..156956
                     /locus_tag="ACL8AS_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HGS1228108.1"
                     /translation="MVLPNFKENLGKYAKLLVANGINVQPGHTLALSIDVEQRELAHL
                     IVKEAYALGAHEVIVQWTDDVINREKFLHAPMERLDNVPEYKIAEMNYLLENKASRLG
                     VRSSDPGALNGVDADKLSASAKAMGLAMKPMRIATQSNKVSWTVAAAAGLEWAKKVFP
                     NAASDEEAVDFLWDQIFKTCRVYEADPVKAWEEHAAILKSKADMLNKEQFSALHYTAP
                     GTDLTLGLPKNHVWESAGAVNAQGEEFLPNMPTEEVFTAPDFRRADGYVTSTKPLSYN
                     GNIIEGIKVTFKDGQIVDITAEKGDQVMKDLVFENAGARALGECALVPDPSPISQSGI
                     TFFNTLFDENASNHLAIGAAYATSVVDGAEMSEEELEAAGLNRSDVHVDFMIGSNQMD
                     IDGIREDGTRVPLFRNGNWAN"
     gene            156966..157196
                     /locus_tag="ACL8AS_000168"
     CDS             156966..157196
                     /locus_tag="ACL8AS_000168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000901571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HGS1228109.1"
                     /translation="MLGSMFVGLLVGFLAGAMTNRGERMGCFGKMFLGWIGAFLGHLL
                     FGTWGPVLSGTAIIPAILGAMIVLAIFWRRGS"
BASE COUNT        47358 a        28387 c        34582 g        46942 t
ORIGIN      
        1 cttctaaaac attgttagaa atcaatttga ctgtcctgat cgatttgtac tgttcttatt
       61 tcattttact atagaacgat ttgaaggcgt ttatgatatt tagctgtacg agagtctttt
      121 aaaagtgttt tgatggtttg gatttcttct ttagttgatt tcatatcact gttatataat
      181 gctttttgat tttagtctag tattagtaag cagactcaaa ccttagaaaa tcttttgaga
      241 tcattgacag gtgtatcgaa tcctaccaca gattcagcac gtctggtttt ggcagaggct
      301 aagaaagctt ttgcagatga tagtttgaca gagcaaggtt tacgtgatat cttgcaaaca
      361 gtcaaagatg ccattgcttc cctagagtcc attaaggaaa gccagtcagc aactaaggat
      421 ggaggacaaa cagcgggcaa agaaacagca ggagaagatg agtctgcaaa tcaaactcaa
      481 gaaattagcc aaggaattaa gtaaacttct taaagactca aaccttgaaa cagtagataa
      541 ggatgtcctt gaaaactctc aaaaagaact tcaaaaagca gttttgttct tggcagatga
      601 aaaaggctct gagcatactg aagcagaggt gattgataat cttaaagagg ttattgctaa
      661 gttgaaagca aacgcctaat aacatattaa aaatctccag attaggaact atcgctgagt
      721 tccctagtct ggagattttt cagtataccc cgttgttgga tgcttataac agagtgacgc
      781 catcactggg ctaatagaga taaaataaac aattgattta ggacatttgt ttgatagtgg
      841 tgataaagtt ttaaatctgc tacataattt gtggagtttt ttctataatt aggagtttaa
      901 cctaacctgc aaataggagt atactaataa tgtaatcgtt atcaaaagtc taaaaaagaa
      961 tttttagatg gatatcaaaa taaaaaggga ggaaattatg aaaaagtttt caaaaacatt
     1021 gagagacaac tggatctttc tcttgatggt tttgccaggg gcactctggt tgattctatt
     1081 cttttacatt ccagtatttg ggaacgtggt tgccttcaaa gactaccaca tgaccagtaa
     1141 tggtttcata gatagtatca taaatagtaa atgggtcgga ctcgataatt tcagattctt
     1201 atttagttca agagacgcct ttattatcac acgaaatact gtcctctaca atcttggctt
     1261 tatctttcta ggtttagttg tatctgtagg gattgccatt atcctcagcg agctccgttc
     1321 taagagaatg gtgaagattt tccaaacttc tatgttgttc ccttacttct tgtcttgggt
     1381 tatcatcagt ttctttacag atgccttcct aaatattgat aaaggggtgt tcaatcatct
     1441 attggaaagt cttggtctca aagaagtcaa tttctacgct gacctgggca tctggcccta
     1501 tctcctactt ttcctaggta tttggaaagg ctttggatat agcagtgtca tgtactatgc
     1561 gacgatcatg ggaattgatc caacctacta cgaagcagcg acagtggacg gagctagcaa
     1621 gtggcaacgt attcgcaacg taaccattcc tcagttgact ccgcttgtaa ctgtattgac
     1681 catccttgca gtcggaaata tcttccgcgc agacttcggt ctcttctatc aaatcccaca
     1741 caatgctggt cagctttaca atgtaaccaa cgttttggac gtatatgtct ttaatggttt
     1801 gactcagaca gcagatattg gtatggctgc agcagccggt ctttaccaat ccgttgttgg
     1861 tttgattctg gttatcctat caaacttgct tgcaagacga gtcgatccaa actcagcttt
     1921 gttctagaaa ggaggagaat atggcaaaaa agaaaattaa aaaagaaaaa attgataatg
     1981 tcggcattca ctccttcagt aagaaagcag atatcttctt cagtatcatt tcgggtttga
     2041 ttgccctctc ttgtatccta ccttttgtat tcgttatcat tatttcagtg acagacgaga
     2101 aaagcctcct ccaatacggc tatagcttct tcccatccca atttggctta gacggttttg
     2161 agtttttggc acagtttaag gataaaatcc tacaagccct cttcatctct gtctttgtaa
     2221 ccgtagttgg gacattgaca aatgtcttta tcacaacaac ctatgcctac gctatttcac
     2281 ggacaacctt taagtatcgc agatttttta ccatcttcgt ccttctcagt atgttgttca
     2341 acgctggttt ggtaccaggt tatatcatgg tgacccgtgt acttcagctt ggtgacactg
     2401 tttgggcctt gattgtgcca atgcttctct ccccctttaa catcatcttg atgcgttcct
     2461 tcttcaagaa gaccattcca gaagccattc tcgaatcggc tcgtatcgat ggtgccagtg
     2521 aggcccggat tttcttccaa atctgtttgc cattgtcact accaggtatc gcaaccatca
     2581 cgcttttgac agctcttggt ttctggaatg actggttcaa cgcccttctt tacatcaaga
     2641 gtgataactt gtatccattg caatatttgc tcatgcaaat ccaacaaaat atggactaca
     2701 ttgccaaagc ggtcggcttg actggtcaac tgggagttgc tctaccgaaa gaaacaggtc
     2761 gtatggccat ggttgtggtt gcaacccttc caatcgcgat tttatatcca ttcttccaac
     2821 gctactttgt aaaaggtttg actatcggtg gtgtgaaaga atagtgctta ttgaaaaaga
     2881 acatttctca gttcccaact tcccttgtgt gaagttaata ctcttcgaaa atcaaattca
     2941 aaccgcgtca acgtcgcctt gccgtactca agtacagcct gcggctagtt ttctagtttg
     3001 ctctttgatt ttcattgagt ataagatcat tacattgttt ataagtttaa aaataaaaaa
     3061 aggagttttt atcatgaaaa actggaaaaa atatgctttt gcatctgcta gtgtagtcgc
     3121 tttggctgca ggtcttgctg cttgtggcaa cttgacaggt aacagtaaaa aagctgctga
     3181 ttcaggtgac aaacctgtta tcaaaatgta ccaaatcggt gacaaaccag acaacttgga
     3241 tgaattgtta gcaaatgcca acaaaatcat tgaagaaaaa gttggtgcca aattggatat
     3301 ccaatacctt ggctggggtg actatggtaa gaaaatgtca gttatcacat catctggtga
     3361 aaactatgat attgcctttg cagataacta tattgtaaat gctcaaaaag gtgcttacgc
     3421 tgacttgaca gaattgtaca aaaaagaagg taaagacctt tacaaagcac ttgacccagc
     3481 ttacatcaag ggtaatactg taaatggtaa gatttacgct gttccagttg cagccaacgt
     3541 tgcgtcatct caaaactttg ccttcaacgg aactctcctt gctaaatatg gtatcgatat
     3601 ttcaggtgtt acttcttacg aaactcttga gccagtcttg aaacaaatta aagaaaaagc
     3661 tccagacgta gtaccatttg ctattggtaa agttttcatc ccatctgata actttgacta
     3721 cccagtagca aacggtcttc cattcgttat cgaccttgaa ggcgatacta ctaaagttgt
     3781 aaaccgttac gaagtgcctc gtttcaaaga acacttgaag actcttcaca aattctatga
     3841 agctggctac attccaaaag acgtcgcaac aagcgatact tcctttgacc ttcaacaaga
     3901 tacttggttc gttcgtgaag aaacagtagg accagctgac tacggtaaca gcttgctttc
     3961 acgtgttgcc aacaaagata tccaaatcaa accaattact aacttcatca agaaaaacca
     4021 aacaacacaa gttgctaact ttgtcatctc aaacaactct aagaacaaag aaaaatcaat
     4081 ggaaatcttg aacctcttga atacgaatcc agaactcttg aacggtcttg tttacggtcc
     4141 agaaggcaag aactgggaaa aaattgaagg taaagaaaac cgtgttcgcg ttcttgatgg
     4201 ctacaaagga aacactcaca tgggtggatg gaacactggt aacaactgga tcctttacat
     4261 caacgaaaac gttacagacc aacaaatcga aaattctaag aaagaattgg cagaagctaa
     4321 agaatctcca gcgcttggat ttatcttcaa tactgacaat gtgaaatctg aaatctcagc
     4381 tattgctaac acaatgcaac aatttgatac agctatcaac actggtactg tagacccaga
     4441 taaagctatt ccagaattga tggaaaaatt gaaatctgaa ggtgcctacg aaaaagtatt
     4501 gaacgaaatg caaaaacaat acgatgaatt cttgaaaaac aaaaaataat cagctaaatt
     4561 gatttcgtgt attcattcct aactcctaaa ataagaatca ctgctttcct caggttggtc
     4621 tggggagggc agtggttttt ttggcacaag gatatagata tccatgtttt ctcttgtcct
     4681 tattttaacc attcaggaaa tttcgagaac cctctacaat ttccagtcaa ataaattgca
     4741 ttcgttttct caagcaggta tactagtatg gataaataaa aaatttagaa aatttaagaa
     4801 tagaaaagag aacaaatctt atggcaaaag atattcgtgt cttactttac tacctttata
     4861 ctccaattga aaatgcagag caatttgctg cagaccactt ggctttctgt aaatcaatcg
     4921 gccttaaagg ccgtatccta gtcgctgacg agggaattaa cggaacagtt tcaggtgact
     4981 atgaaacaac tcaaaaatac atggactacg ttcacagcct tccaggaatg gaagaacttt
     5041 ggttcaagat tgacgaagaa agtgaacaag ccttcaagaa gatgtttgtt cgctacaaga
     5101 aagaaattgt ccaccttggt ttggaagaca acgactttga caatgacatc aacccacttg
     5161 aaacaacagg tgcttacttg tctccaaaag agttcaaaga agcgcttctt gataaagata
     5221 ccgttgtcct tgacacacgt aacgattatg agtacgacct aggacatttc cgtggagcta
     5281 ttcgcccaga tattcgcaac ttccgtgagt taccacaatg ggtccgtgat aacaaggaaa
     5341 aattcatgga caagcgtgtc gtggtttact gtacaggtgg cgttcgctgt gagaaattct
     5401 caggctggat ggtccgtgaa ggctacaaag atgtcggcca attgcacgga ggaatcgcaa
     5461 cttacggtaa agacccagaa gttcaaggtg agctttggga tgggaaaatg tacgtctttg
     5521 acgagcgtat tgccgttgat gtcaaccatg tcaacccaac catcgtaggg aaagactggt
     5581 ttgatggaac accatgtgaa cgttatgtca actgtggaaa tcccttctgt aaccgtcgta
     5641 tcttgacatc agaagaaaat gaagacaagt accttcgtgg atgctcacac gagtgccgtg
     5701 ttcacccacg taaccgctat gtttcaaaaa atgaattgac acaagctgaa gtgattgagc
     5761 gcctagccgc tatcggtgaa agcttggatc aggcagctac tgtataagat caaacagtcc
     5821 tcaggggctg tttttctatg ctttgtactc aaaaatctaa agtttgtttt tgtatctttc
     5881 aggaaaataa ggtatactgt atgtaaacga tttcaaagga gtccagttat ggcaaaaaca
     5941 ttttttattc caaataaaca gagcatttta ggagaacaag agattttgaa tgccaagtcg
     6001 atcttggcct tgctagacgg tttggagtca catagctatg atgtagtcta tcttcgtcag
     6061 cctcttaatc gtctcgagta tattgagtgt gcgatagtgg ggcaatcaca atttctcttt
     6121 aaggtcagtt atgctgatgg tcaaaaggct taccgtgtcg atcttcctga cctactaaca
     6181 gagacagact ggcggattat caagtcattt ttagatgctt tgcttgctta tacagggact
     6241 gatattgaag ggctagatgg ttttgatttt gaagcttatt tccaagcaag tattcaagcc
     6301 tatctagcag accctgtagc tcgttttacg atttgccaag gaatttttaa tcctattttc
     6361 tttagtcgtg agaacttgaa aagcttttta gaggcagatg gcttggctca gtttgaagcg
     6421 cgtgtgcgtg cggttcaaga gacagatgcc tactttgcga gagtttcatt ctatcaggat
     6481 ggagaaggaa aagtgcatgg cgtttaccat ctagctcaag gagtcaagac agttttaccg
     6541 agagaaccgt ttgttcctgc agcctatatt gagcaattgg tggataagga agtccagtgg
     6601 gagatcgact tggttcaaat cacaggagat ggctctaaac cagaagacta tgaagccatc
     6661 gcccgcttgg actatgcaaa attcctagag tcactaccat cagcatttta ccaccaacta
     6721 gacgccaatc aattagaagt acaacccatc ctaggacaag attttaaaac attagcacaa
     6781 gaaaagtaaa gcagaagcag gtcaatcgac ttgctttttt gacatagaaa aaatcctgcc
     6841 aaggatgaca ggattgaatt ttaaagaaag gccaagatac gaagataatc tccaatcagt
     6901 gccacttcag ctacaaagaa gaggaggata ataactccgt tcacaaggac agacaagaat
     6961 aattgataga aggagtcggt ttcacttgct tgacttggtc ttgtaatgat atggagactg
     7021 gcaagcagaa tgattccaat gctaatcaca cacaagaggg ctgtaaatcg taggctatca
     7081 aagaaagcaa agaaactagc aatagcagtg aggaagattg gaattgccaa gagttgacta
     7141 tattgttgga gaaccttgtc tagcgtccag tccttttcct ggtggataaa tcgtctcaca
     7201 acgaaactac ccaagaggaa tgaaaagaag aagagtgttg tcgctactag gatagagatg
     7261 atagaaaaaa gagttaaagg agctagctgc tcagggaagc gactgttaat gcttgctata
     7321 tgtccatagt aagcatgttt gatgtgatag atactaaaga aaaaggaaga tgcagaaaac
     7381 agaatgagca agagaaaggc tgtgtaactg tgtgtgatac ttgtttcaaa cttacttgta
     7441 ggagatttga tcgcttccac tagccaagac caaaaatcaa gcacttgctc tttccattta
     7501 tccctagatt ttggagcttg gtcggggata taaggacttt ctaaagattt actgataaga
     7561 agtggctctt tcgtggttgc tttttgctga ggaagagctt cttggctctc ttcagctata
     7621 gtgacttttt ctgtttcttt agaaaggtct gactcttctt cagtagaatt agatgccttc
     7681 ttttcttcta tttctgttct cgcttcaccg acttcaggag tttcaatttt ctcttcttgc
     7741 tggctttcca gttcgacttc agcttgagag acttcctcct ctacttgagt attttttcca
     7801 attggtgtat cgaaatcggc tatcgtttct tcagccttgt ctgcaacctc ttgagcttgc
     7861 tcttcaggct tgttcttgct tgttgttttt acaaaatcat tactttcaaa ccattcttgt
     7921 ttcatggtag aacctccttt ttggttagat aaatatgctt ccatagtagc agatgtaagc
     7981 gtttttgtca acgtctgctt ggtgtggata ttagatcaat attatcatca gatctcgcaa
     8041 tgagttgatc cttgacatcg gttttttcag ttttgtaagg gttgcttaat tccgtacctc
     8101 ttgattcagg cttttctctt gtgaattgga agatagaacc atagttgctt gagatgtccc
     8161 agttaattcg ttggctttct ttctggtcta ggatgattct gagataatct ttggcagtca
     8221 gttcaacctt gccatggact tggatatttt cagcgtggaa gtgattctct gttgactcta
     8281 gctgactatc tgtaagaact gtatcaaaga tattaacgat attgggcgtt gtgagtttac
     8341 tgtttttgat acgacttcct tcaattcgga ggatatagct gtttgtattg agggttgcat
     8401 tttcaaggct agcatttatg atggtggttt gtccgcgatt ggctgagatg ttgatccctt
     8461 ttagagttct cccttttggt agctggagaa taacttcttc aaaacgacta gagtagctac
     8521 ttgcgatatg aagaatccca ccaattccag aagagagaaa cggagtttca gacagtttct
     8581 tatcagtgag actcagagtt ctatcgttct gattggtgat aagatcatgg tgagcagaaa
     8641 gagatggatg gtaagaaatg tggatttgat catcgaaaga gtctgtgatg gtgagcgcgt
     8701 gttggtggag agtaatttct aggttttcga cttccttgcc aaaggttagc ttttccgtac
     8761 ggctatcata gacaggttct ttggacatgg aaagtaggct cttaatcccg tcagattgga
     8821 tacctacaaa aagcaggata aagccgataa cggtagtcac cacaccaaag atgagaaatc
     8881 cttttgtcca tttacgcatg ctgattacct ctctttcctt ttttaagaac aaattgtacc
     8941 agacgaacaa tgagtagacc gaagaagcga gctacatagg aaatgccaag taaaactagc
     9001 gaagaagcac cgatagccag taaaccagaa ccaaaaatca agataaaggc tgatttggct
     9061 tgggcgagga tagtgaaact ttcaactaaa aataggaatc cgccgatgat acccagtatg
     9121 gaaactgcaa agaaagccag aatgacagtc aaagcggcta caaggattgc gaacagggtc
     9181 acgaggatgg cgattcccag aggaatgccg ataggtgctg caaggagggc taacaaggcg
     9241 atatgtaaaa tttgtcggtt atttttttga gcgggtgctt cattgatttt tttatcgaga
     9301 agattggata gaacttcgtg ggccgctgct ttgggagttc ccaaactagc gatgagttct
     9361 tcttctcctt cgactccagc atcgtcaaag agctctctga aatagtccat ggcttcgata
     9421 cggtcagctt caggtagttt cttgagatag agttctagct gagtcaggta ttcagttctt
     9481 gtcatggcgg atactccctt ctatgatgcc attgatggtg tctgtataga gtgcccattc
     9541 atcttttagg gtcaagagct gctctatacc accgtttgtc aaggagtagt atttgcgcat
     9601 gcgaccttgg aactctctag aataggttgt cagaaagcta ttgccttcca attttttgag
     9661 aatgggatag agtgtggatt ctttgatatt agcgattagc ttaatggttt ggctaatctc
     9721 ataaccataa gaatcaccct gctccagtac ggccaagatg agaaattcaa tcaaggcaga
     9781 ggatgttgga aagtacatgg gaaacctcct tttctaatgt gtaagatttt tatatataat
     9841 ttttctacac atacattgta catctaaaag aaagccctgt caagagaaat gtgtaaaatt
     9901 tttatatata aaaaacttct agctaaaact agaagtttaa aggatcttat ccgctctgtc
     9961 cactgtaaag agggccacag tcatcaggat atcgatgagc aagagggcag ctacagatgg
    10021 tacccaagag tggaacaggt caaaactgta accaaagagg gttggcccaa aggctgctag
    10081 gatatagcct cctgtttgag ataggccgga caattgggct gtcttttcag gggcgcttgt
    10141 cttgagtgaa aagttgacca tgagataagg gaagagggca ctggttgcgg ttccgatgag
    10201 gagatggatg gcaagccagt aaatgaaatt attgattggg aaaaagagca tggaaatgcc
    10261 gaccacacca gctagtgaaa ccagagtgag catgagctga cggttgcgag tagataaact
    10321 ggttgtcagg cttgggatgg tcattgaaaa aggaatgcta atcagagata agatagaagt
    10381 cagcaagcca gcttcgtgac tggatagacc tgcatggata gacatggtag gtaaccaggt
    10441 catgacggtg taaaagatca aggattgaaa acctgaaaag ataataattg cccaaacctg
    10501 tttattacgc atgaccttta tttgactttt ttgtttggtt tgtggagcta gtctatgatt
    10561 atagcggtga tttgggagcc agaccaaaaa agttgctaga cagagtaacg tgaggagaag
    10621 gataagtcct ttccaagaac tggcttgtgt aatgggcaca gctagatagg aagccagagc
    10681 cgttgcaatc cccatagacg ttacatataa ggtggtcaga aaaccaattt tctttggttg
    10741 attggcttgg ataagactag gaagcaggac attgatgact gcgacacttg ccccaaccat
    10801 caaggttcct agatagagca ggggcagatt gattagtcga ataagtgagc cgatggtcaa
    10861 gaagaagagg ctgtaggtga agagatgctc caagccgatt ttctgagcca gttgggtaga
    10921 aaatggtgaa aagagggtaa acataaggag aggcaggctg gtcaagacac caagcgaact
    10981 aacttctacc tccagacctt gcgaaatatt tcccaaaata atgggtaaaa cagtaaaagg
    11041 agttcgcaag gaaacaccaa tcaggataat acctggaaca aaaaagagtg attgcttttt
    11101 catataatac ctcttctagc tgattttaat aacagcttat tttaaggctt tttcactata
    11161 atgtcaagta aggtttctgg ctttcaagat aaaaatggga aagtcttgaa aattatgata
    11221 gaatggtgga aggaaaaatt caggagagta gtagtgactc aaaatgttga aagtcttctc
    11281 gtatccattg taatcagtgc atacaatgaa gaaaaatatc tgcctggtct aattgaagac
    11341 ttaaaaaatc aaacctatcc taaagagaat attgaaattc tatttataaa tgctatgtcc
    11401 acagatggga ccacagctat cattcagcaa tttataaagg aagatacaga gtttaactca
    11461 attagattgt ataacaatcc taagaaaaat caagctagtg gttttaacct gggagttaaa
    11521 cattctgtag gggaccttat tttaaaaatt gatgctcatt caaaagttac tgagactttt
    11581 gtaatgaaca atgtggctat tattcaacaa ggtgaatttg tctgtggggg gcctagaccg
    11641 acgattgtcg aaggaaaagg aaaatgggca gagaccttgc atcttgttga ggaaaatatg
    11701 tttggcagta gcattgccaa ttatcgaaat agttctgagg atagatatgt ttcttctatt
    11761 tttcatggaa tgtataaacg agaggttttc cagaaggttg gtttagtaaa tgagcaactt
    11821 ggccgaactg aagataatga tattcattat agaattcgag aatatggtta taaaatccgc
    11881 tatagcccaa gtattctatc ttatcagtat attcgaccaa cattcaagaa aatgctgcat
    11941 caaaagtatt taaatggttt gtggattggc ttgacaagtc atgttcagtt taagtgttta
    12001 tcattatttc actatgttcc ttgtttattt gttttgagtc ttgtgtttag tctagcattg
    12061 ttaccgatca cattcgtatt cataacttta ctattaggtg cctattttct acttttgtca
    12121 ctactcactt tgctgacttt attaaaacat aaaaatggat ttctaattgt gatgcccttt
    12181 cttttatttt ccattcactt tgcttatggc tttgggacga ttgtaggttt aattagagga
    12241 tttaaatgga agaaggagta caagagaaca ataatttatt tggataaaat aagccaaata
    12301 aacaaaaata tgctataata acaatatagt aaaactcttt taaggaggag tagatttcta
    12361 tgaataaaaa actaacagat tatgtgattg atctggtgga aattttaaat aaacaacaaa
    12421 agcaggtttt ctggggaata tttgatattt tcagtatggt ggtttccatc attgtatctt
    12481 atattttatt ttatgggctg attaatccag cacctgttga ctacattatc tatacgagtt
    12541 tggccttcct gttctatcaa ttgatgattg gtttttgggg gttgaacgcg agcattagtc
    12601 gttacagcaa gattacggat ttcatgaaaa tcttttttgg tgtgactgct agcagtgtct
    12661 tgtcatatag tatctgttat gccttcttgc cactcttctc catccgtttc atcattctct
    12721 ttatcttgtt gagtaccttc ttgattttat tgccacggat tacttggcag ttaatctact
    12781 ccagacgcaa aaaaggtagt ggtgatggag aacaccgtcg gaccttcttg attggtgccg
    12841 gtgatggtgg ggctctcttt atggatagtt accaacatcc aaccagtgaa ttagaactgg
    12901 tcggtatttt ggataaggat tctaagaaaa agggtcaaaa acttggtggt attcctgttt
    12961 tgggctctta tgacaatctg cctgaattag ccaaacgcca tcaaatcgag cgtgtcatcg
    13021 ttgcgattcc gtcgctggat ccgtcagaat atgagcgtat cttgcagatg tgtaataagc
    13081 tgggtgtcaa atgttacaag atgcctaagg ttgaaactgt tgttcagggc cttcaccaag
    13141 caggtactgg cttccaaaaa attgatatta cggacctttt gggtcgtcag gaaatccgtc
    13201 ttgacgaatc gcgtctgggt gcagaactga caggtaagac catcttagtc acaggagctg
    13261 gaggttcaat cggttctgaa atctgtcgtc aagttagtcg cttcaatcct gaacgcattg
    13321 tcttgctcgg tcatggggaa aactcaatct accttgttta tcatgaattg attcgtaagt
    13381 tccaagggat tgattatgta cctgtgattg cggacattca agactatgat cgtttgttgc
    13441 aagtctttga gcagtacaaa cctgctattg tttatcatgc ggcagcccac aagcatgttc
    13501 ctatgatgga gcgcaatcca aaagaagcct tcaaaaacaa tatccgtgga acttacaatg
    13561 ttgctagagc cgttgatgaa gccaaggtgc ctaagatggt tatgatttcg acagataagg
    13621 cagttaatcc accaaatgtt atgggagcaa ccaagcgcgt ggcggagttg attgtcactg
    13681 gctttaacca acgtagccaa tcaacctact gtgcagttcg ttttgggaat gttcttggta
    13741 gccgtggtag tgtcattcca gtctttgaac gtcagattgc tgaaggtggg cctgtaacgg
    13801 tgacagactt ccgcatgacc cgttacttta tgaccattcc agaagctagc cgtctggtta
    13861 tccatgctgg tgcttatgcc aaagatgggg aagtctttat ccttgatatg ggcaaaccag
    13921 tcaagattta tgacttggcc aagaagatgg tgcttctaag tggccacact gaaagtgaaa
    13981 ttccaatcgt tgaagttgga atccgcccag gtgaaaaact ctacgaagaa ctcttggtat
    14041 caaccgaact cgttgacaat caagttatgg ataagatttt cgttggtaag gttaatgtca
    14101 tgcctttaga atccatcaat caaaagattg gagagttccg cactctcagt ggagatgagt
    14161 tgaagcaagc tattatcgcc tttgctaatc aaacaaccca cattgaataa aaaagaaaaa
    14221 cgcatagtat caagttacac aaccttggta atatgcgttt tattatgtag agacttatac
    14281 tcttcgaaaa tctcttcaaa ccacgtcaac gtcgccttgc cgtaggtatg gttactgact
    14341 tcgtcagttc tatccacaac ctcaaaacag tgtttagagc tgacttcgtc agttccatcc
    14401 acaaccttaa aacagtgttt tgagctgact tcgtcagttc catccacaac cttaaaacaa
    14461 tgttttgagc tgacttcgtc agttctatct gcaacctcaa aacagtgttt tgagcagccc
    14521 gcagctagtt tcctagtttg ctctttgatt ttcattgagt attacttcat tttcttctga
    14581 aatggaattg ttacccagtc tatgctattg aaaatacgcc aaaacttcta agggtttgtg
    14641 agcgatataa tcaggttgat agtttagtag atctgcttgc tctccaaatc cccaagtgat
    14701 ggccaatttc tgaatacctg tttctcgagc tcccagcata tcaaacttgg tatctccgat
    14761 gatgatggct tgttctggtg ctagttgatg tgtctgcaag gcttggtgaa tgacatctgc
    14821 cttatggggt gcttcagggc tagaaccata aatgccatca aagaaatgat ggatttccaa
    14881 gttttttgcc atgtcttgag cagtagatgt atcctttgtc gtggtgatgt agagtggata
    14941 actgctcgat aactcctcaa gcaagtctat aatctgagga aagagttgag cttcatagat
    15001 gccttttgcc ttatagtaag aacgatatat ctgcacggct tcagaaattt ggtctttgga
    15061 caggcaggtc gcaaaactac tttcgagagg tggtcccata aaaccacgaa tagttttggc
    15121 atcagggcta ggcaccccca gctctttaaa ggtataggta aaggcattgt gaatcccgat
    15181 agaactatca acgagggttc catccaaatc gaaaaaaatc gctgtgatag aggtcatggt
    15241 ttctcctatt tgataagctt attctccgaa aatttctttt tggaggcgac gaccagtagg
    15301 ggtggtagcg agtccacctt cagctgtttc acgaaaggca gttggcatgc ttgctcctac
    15361 ttggtacatg gcatcgatca cttcatccac agggatttta gattcgatac ctgccaaggc
    15421 catgtctgct gcgatgaaag caaagctagc tcccatggca ttacgtttga cacagggaac
    15481 ttcgaccaaa cctgcaacag ggtcacagat gaggcctagc atatttttaa tgacaaaggc
    15541 aatagcttga ctggcctgat aaggtgttcc acctgcagcc agagtcaagg cggcagcact
    15601 catagcagag gctgaaccaa cttcagcttg acacccaccc tcagcacctg agatggaggc
    15661 attgtttgcg atgactagtc caaaggcacc agcagcaaag aggaaatcca attgttgctc
    15721 gtggctgagg tctaattttt caatagcagc agtgagaacg gatggcagac agccagcact
    15781 tccagcggtt ggagtggcac agaccaagcc cattttggca ttgtgttcat tgactgcgat
    15841 ggcatttcgg gcagccgaga gaatcgtata atctgacaga gtttttccgt tttcgatgta
    15901 gtgatccaat ttggcagcat ctccacctgt caggccacta cgagatttat tttcattgag
    15961 gccaagttgg acagaggctt tcataacttc cagattgcgt tccatgagaa ggaagacttc
    16021 ttcacgttcg cgaccggtca attcaaactc tgttgtaatc atgagttctg cgacatttcc
    16081 ttgaaagtcc agatctgctt gctcgaccaa ttctttgata gaataaaaca tgcttcctcc
    16141 tatttaaaga aattgacatt gtggagatga gggatttttc gaatttcttc gatagcctca
    16201 tcacagttgc gactgtcaac ttcgataatc ataatggctt tttcaccagc tttttcacga
    16261 gtgacattca tctgggcgat attgatacca tagcgggaaa gcgcctctgt aacaagggca
    16321 atcatacctg gaatatcttg atgaacgatg atgatagtcg gtgtattcat attgagagag
    16381 acggcaaaac cattgagttc ggttacctga atatttcctc caccgataga aataccagtc
    16441 acgctgatgg tcttgtgggc atttttaaca gtaattttag tggtgttagg gtgaggggca
    16501 ttgctgtctt tctgaatggt ccagacaatc ttgataccac gcttgtgggc aatttccaga
    16561 ctatttggaa tttcaggatc atctgtatcc attcctaaaa tacctgcaac aagggctagg
    16621 tctgttccgt gaccacgata ggtcttggca aatgagttaa aaagttggaa ttcaacttct
    16681 gtcggagtat catcaaaaat ggaagagaca atcttcccaa tacgaacagc accagcggta
    16741 tggctactag atgggccaat cataactggt ccgatgatat caaagacaga ttgaaaacga
    16801 agtgatttca tcagtttccc cttataaaaa ttcttatctc tattatatca aagaatgagg
    16861 ggcttggctt taattgtgga tgaaaacctt tctaatacct caaatagcat aaaaatagta
    16921 tcttttatga caaaaacacc ttatttaggg aaataaaaaa taattttgta atatttctac
    16981 ataaaagtgt caagaaacgg taatatttaa agggtatgat agaactatag aaagaaggag
    17041 aattttcgaa tatgaaatca ataactaaaa agattaaagc aactcttgca ggagtagctg
    17101 ccttgtttgc agtatttgct ccatcatttg tatctgctca agaatcatca acttacactg
    17161 ttaaagaagg tgatacactt tcagaaatcg ctgaaactca caacacaaca gtggaaaaat
    17221 tggcagaaaa caaccacatt gataacattc atttgattta tgttgatcaa gagttggtta
    17281 tcgatggccc tgtagcgcct gttgcaacac cagcgccagc tacttatgcg gcaccagccg
    17341 ctcaagatga aactgtttca gctccagtgg cagaaactcc agtagtaagt gaaacagttg
    17401 tttcaactgt aagcggatct gaagcagaag ccaaagaatg gatcgctcaa aaagaatcag
    17461 gtggtagcta tacagctaca aatggacgtt atatcggacg ttaccaatta acagattcat
    17521 acctgaacgg tgactactca gctgaaaacc aagaacgtgt agcagatgcc tacgttgcag
    17581 gacgttacgg ttcatggaca gctgctaaaa acttctggct taacaatggc tggtattaag
    17641 aactaacgaa caaataatat gtaaagagtc gaggaaatcc ctcggctttt ttatctttcc
    17701 ttcgcttggt aatagatctc tacttctttt ttgagatgag acagcataga agtttcctcg
    17761 gttagctcta ggagtgagaa acctttttgg ataagtttcg catcatccct acaaatccca
    17821 atagggacat agcagatagc cagcctatcg tagcttttct tattcttggc gtcctccagt
    17881 aaagtgtagc agatttgctt acacatgttt ttatcttgat tgtatagata gagtgtggaa
    17941 aggttgagca ggattgctat tcgcaagtca tataaatgtt gatagttttt atagacttct
    18001 aagcgttgca agattttctc ggattattga caaataaacg gacattctga tagacgattg
    18061 ccctagcggc ttagtgtaaa ctttacaaat ttggcttgta atttttttat aaaattcact
    18121 tcagttactt gacagttatt atattttcac ttattatata gataaaagga tgggatagga
    18181 gtttaaaaat ttgaaagcgc tatccatatt gtttattgga ctgattcttg agtaatagtt
    18241 agagtgtgct taatactact ctggttgttc aaggacctga tacagaagcg caccattctc
    18301 ccggttaaga gtaagttcgt tgttaaaaaa tgaaatgaga tagaaggaag gtgagtccaa
    18361 tggactacga tacttgttga taaattacta tagctgtttt tacggaacag ctctcgataa
    18421 taggagaaat aaatcatgag aaaattagtt aaaattggtg ttgcatcttt aatggtatgt
    18481 ggtatacttg ctactacaaa tgctttagca gtatgggttg agggtggtca atggaactat
    18541 ggagtaggtt ggacaggaac ttttggatat tctgattact tacattctac tcgatatcat
    18601 acagcaactg ttagacatgg gggtagaacc tctaaggatt atgcaaaacc tgaggcatgg
    18661 gctatagctt ccctcaccaa gattccgcca acaggaatgg aatatttcta tggatttgag
    18721 taaaattctt ccctctccta tttggagagg gaaaactgta gtggaggcac ttttatgaaa
    18781 aaaatcagta atttctgtat gttactcctg cttctgtgta ccactttttt tgtttttaat
    18841 gtaaactata cacgagaagt ggttcggatt caagaaatgg gaaagactgt agattctttg
    18901 gatttgtatt tgaaagatat taacgaacct gcagcgtctg ttcttcgatt ttttgaggat
    18961 gtatcaaagg agtataaagt ctccatcatc aaaacagaca gtggtgatga ggtggtcaag
    19021 tctggtgttt ttgataaaga taccttcccc taccaagagt ttgggatttc ttctcttgat
    19081 tttaccacag atggtgaagg agtctatagt aataaagaaa tttccaataa acttggtacg
    19141 attccgacct ttctaaaagc caaacctatt cagcttatga cttttcaaac ctatatcaag
    19201 gatacatctc gtagtttaaa tggtcgctat acgataactt ctacacaaga gatggacaag
    19261 gataggattg tacagaaatg gagcgatttt ttcaagatag accaggctac cttgctagag
    19321 ccgacctaca aaagtgcagt ggaagtcata aatcgagatt tgcttttatc tgccattgtt
    19381 tttgtcttgg ctattttgct tcttgtgtta gtgacagtgt atcaaccgat gatggagatg
    19441 aaaagagttg gggtacaaaa attacttggt tttcaagata gggctgtttt agctgatgtt
    19501 gtaaaaggca acctttacct cctcctaggt ggggctcttg tgatcaatct aggcgtgttt
    19561 ttcttgcttg attataagcc aaaagatttg tttcctatgc tgtggttgtc tcattttttg
    19621 ctgttgcagc tttatctctt tatcagttgg ttgacttacc tcttaatcca aaaaatgaca
    19681 atcagctctc tgctgaaagg tttttcatct ttcaaatttg gtcttatctt caattatgtg
    19741 atgaaaatag ggacaactat tttactgacg gccttactga ttggggtggg cagaagttta
    19801 gaacaagaaa acaaagaact tgcttatcag caacagtggg taagtcaagg taattacctg
    19861 accttagaaa ccttcaaact caatgataat ctgtggcaag aagagctagc agggtcaggg
    19921 aaatctacag attatttcta tcgattttat caggatttgg tagaaaaaac gcaggcgggc
    19981 tatgtgcaga gtagcagtct tcctgtaaaa aattttgtcc aatcagaaca gattcagcaa
    20041 tatcagttaa cagatacggt ggatgtttac tatgccaatc gcaattttct aaagagcaag
    20101 ggattcaagc taccagatac cggtattaaa aaagttattt tgatgccagc aagtacgaaa
    20161 ggtgaagaag ataaaaatca gctcttgggg aagttaattg cctttcattc gatgaagtat
    20221 gaagagcagc aaaaacgaac gatagaggag atggatgtcg agattgccta ttatgaagga
    20281 gattggtcat ttttcccata tagtgataag cgaaaggaaa atctctccaa tccaattatt
    20341 agcttggtca atgattctga tatgatgtgg gatgagaaag cctccctgtc aacaactggc
    20401 ttaaataatc cgattaaaat tgaaaatacg gttcaacatc aaaaagagat tacagagtta
    20461 gttgagaaat tgtcagatgg aaattattta aaattttcat ctattcaagc cattcaacaa
    20521 gagaaagtgg attcttatag agatgctgtt cggaatttta acctactctt tgctttgttt
    20581 ggtctcctta gcatgatgat ttcctacttc ttactagtaa caactttctt attgaagcgc
    20641 agggatatca ttaccaagaa gtttatgggg tggaaactgg tcgatcgcta ccgtcctctc
    20701 ctcgttctgc tcttgctggg ctatagtttc cctcttctag tcttgatttt ctttgctcat
    20761 gcgttcttac cacttctact gtttgcaggt tttacatgtc tggatatact atttgtgcta
    20821 ggcttagctt ctaggatgga gaaaagaagt ctagtagagt tattgaaagg gggcatctta
    20881 tgattgagtt gaaaaatatt accaaaacca ttgggggaaa agtgattttg gataacttat
    20941 ctctcaggat tgatcagggg gctttggtag ccattgttgg caaaagtggc agtggcaagt
    21001 cgaccttgtt aaatttattg ggtttgatag atggtgatta tagcggacgg tatgagattt
    21061 ttggtcagac aaatctagcg gttaattctg ctaagtcgca aacaataatc cgtgaacata
    21121 tctcttatct gtttcaaaat tttgccctga ttgatgatga aacggtcgag tacaatctca
    21181 tgctggcgct gaaatatgtg aaattgccta agaaagacaa gctcaaaaag gtggaagaga
    21241 ttttagagag agtaggtttg tcagctactt tgcatcaaag ggtctccgag ttgtctgggg
    21301 gcgaacaaca acgaattgca gttgctagag ccatcttaaa acccagccag ctgattttag
    21361 ccgatgaacc gacaggttcg ctggatcctg aaaatagaga tttggtcttg aagtttctct
    21421 tagagatgaa tcgagaaggg aaaacagtca ttattgtgac ccacgatgct tatgtagccc
    21481 aacaatgtca tcgtgtcatt gaattgggcg agggaaaatg agttcattca gctccttttg
    21541 actggctgaa tactcatgtt ttccagagaa aaatagcata aatacgccta ggaatgacat
    21601 tttatgtagt atttctaggt tttttttgtt tcaaattgaa aattttttca atttaggctt
    21661 gacaaaggat gagtatagga gtattattta tacaataaaa aagaataaac ataaaggagg
    21721 ctttgttatg aataagatga agaaggtgtt gatgacgatg tttggtttag tgatgctccc
    21781 cctactattt gcttgtagta acaatcaatc ggctggaatt gaagccatca agtccaaagg
    21841 aaaattggtt gtagccctca atccagattt tgctccattt gaatatcaaa aagtggttga
    21901 tgggaaaaat cagattgtgg gttcagatat cgaattagcc aaggctatcg caacagaact
    21961 aggtgtcgaa ttggaactat ctcctatgag ttttgacaat gtactggcta gcgtttaatc
    22021 aggaaaagct gaccttgcca tatcaggtgt ttctaagaca gatgaacgga gcaaggtgtt
    22081 tgatttttca actccctact atactgcaaa aaataaactc attgtcaaaa aatctgattt
    22141 agccacttat cagtctgtca acgatttggc gcagaaaaag gtcggagcgc agaaaggttc
    22201 gattcaagag acgatggcga aagatttgct acaaaattct tccctcgtat ctctgcctaa
    22261 aaatgggaat ttaatcacag atttaaaatc agggcaagtg gatgccgtta tttttgaaga
    22321 acccgttgcc aagggatttg tggaaaataa tcctgattta gcaatcgcag acctcaattt
    22381 tgaaaaagag caagatgatt cctatgcggt agccatgaaa aaagatagca aggaattgaa
    22441 agaggcagtc gataaaacca ttcaaaagtt gaaggagtct ggggaattag acaaactcat
    22501 tgaggatgcc tttaaagcgt ccattgaaaa atagaaagaa ggaaaagaac atgagtaaag
    22561 aaaaagtaat tttggcctat tctggcggtt tagacacatc agttgctatt acctggctga
    22621 agaaagacta tgatgttgtt gcagtttgta tggatgtggg tgaagggaaa gacttagatt
    22681 tcatccatga taaggctctt aaggttgggg cagtcgaatc ttatgtcatt gatgttaagg
    22741 acgaatttgc tacagattat gtgctagtag ctctccagtc acatgcctac tatgaacaaa
    22801 agtacccctt ggtatctgcc ttgagccgcc ctcttatttc taaaaaattg gttgaaatag
    22861 cgcatcagac aggagcgact acaattgctc atggttgtac aggtaagggg aatgaccaag
    22921 tcgaatacca gattgcagtc gctaagaaag cgaatgaagc taaaaagtga tggagtgatg
    22981 ggttcagaat aagaggttgg tagattatca gcctctttct tgtcgttgaa aaagtgagat
    23041 atattgactt ttgaaaaaaa tgtcataatt gagttgggat aaacgtaaaa gtcatacttt
    23101 ctcgttaaat cgttcggcga ttcatggtga catggacaca tagaagtaaa cacactatgt
    23161 ggcttggcag agctaaaaac ttctggttta acaatggctg atattaagaa ctaacgaaca
    23221 aataatatgt aaagagtcga ggaaatccct cgactttttt tataatttct ttggttgata
    23281 atgggtctct acttcttttt tgagatgaga cagcatagaa gtttcctcgg tcagctctag
    23341 gagtgagaaa cctttttgga taagtttagc attatcccta caaatcccaa tacgaacata
    23401 gcagatagca agcctatcgt agcttttctt attcttggcg tcctccagta aagtgtagca
    23461 gatttgctta cacatgtttt tatcttgatt gtatagatag agtgtggaaa ggttgagcag
    23521 gattgctatt cgcaagtcat ataaacgttg atagttttta tagacttcta agcgttgcaa
    23581 gattttctcg gattattgac aaataaacgg acattctgat agacgattgc cctagcggct
    23641 tagtgtaaac tttacaaatt tggcttgtaa tttttttata aaattcactt cagatacttg
    23701 acagttatta tattttcgct tatgcttatt atatagataa aaggacggga taggagttta
    23761 aaaatttgaa agcgctatcc ataatcataa cgcataattt tctccttttc gtgaaaaaag
    23821 ttaacgtaat tttgaaatga gcttaataag aggtactatg taggtagaaa ataaagatag
    23881 gagaaaaagt atgaataaaa aaatattttg tattctagta tgtattatat cattgattag
    23941 tctagctata atctttccat ggggctggtc gatataatgt aagggagctt gagttgttag
    24001 tggaggataa aatgttaaga gtaatagtag ttattcaatc tttagtaata atactgcttg
    24061 ctgttgcttt attattatct cggaaaaact ttgattcgtt aaatgttgtt cttataatga
    24121 tgatcgtatc acaattgttg ttattagtat atttgataaa atcagggaat cagtgattag
    24181 ctgttatttg aattaagtaa actgttaagc ttcaagcagt aactggtttt aaatatttaa
    24241 aataagataa aggaaggaag tctaatttag gtaactaaac aaagcctgcg atcacttgtt
    24301 aggaaaccat cctaaccatg cttaataaaa aaggagaaaa taaatggaac ttgtattacc
    24361 aaataattat gttgtgattg atgaagaaga gatgatgtac cttgatgggg gagcttattt
    24421 aagcaagcgt gcttgtcaag gaatttgcgc agctttagct atgagtccag gaacttttat
    24481 agcattagct ggagctgcag ttttaaccaa aaaactaata aactatatta aagttggagg
    24541 ccttggaggt tggcttattg gtgcagcagc aggtgtattg gctggggcgg caggaagaat
    24601 agcttactgt attggatatg gtgctcttaa tagaggttgt gatattagcg ggaaccctta
    24661 tccttgggat ggattcatat ctgcgacagt aagatgagta atgtagataa gattcgaaaa
    24721 atacacatta tcgtatgttg gatgtatata tttttatcat tcagggcgat tataaatgac
    24781 acggagtatt ttttgcttat ttttttagct tttatctact caatagtatc actacctcta
    24841 tattctgtga aaaataaaat agtatctatc tgtctagcca taaattcgat tctgttaatg
    24901 agtttcccca ttttaatcaa taagtttttc ccagaaagtt ttttgactta taccgtatta
    24961 ataagtgttt ttattacaga gttgataatt tttcatttaa ttgggaaaga ttttgatatt
    25021 aaattgacta acgaatataa gaaaattagt cagtttagaa gcaaggtgtc tcaatctcct
    25081 tggataaaat atttagagat ttctagtttt atattaacta tatttccatc tattctttat
    25141 ggtacagttg ataatcatgt actgactctt atctttttga taaaaatttg tgcagatacc
    25201 acgataaaat ttttattcat cagattattt gacacaagta ctttaatgaa gaggagaata
    25261 ttttttcttt tcgcattgga tgttatagct tacttatttt taggatatct tttagtgatt
    25321 caaaaagcag gctatttgtt ttcggtttta cttctttttt ctaatttttc agttccattt
    25381 atcaaagaaa aggaatacga attatttaaa aatagcaagt aatagaaaca taggttaaat
    25441 cttagaacgg cttaaaatca gatatgataa agggaaatag tcttatctag gtaactaagt
    25501 gctacaaaca cagtcgagga tcacttgtta ggattacatt ttaatcatgc ttaataagaa
    25561 tggagaattc ctatggggat tgtattactc tgaactttcg aataccttag ttctcgtgat
    25621 tttgagctat tctagcttta gaatccttca gaatgtaaaa ttttaagcag tcaaagactt
    25681 agaatagcct gaaaacattt attttatagc aattctaggc ttagaattgc tcatatatat
    25741 gtatttgagc tgctcgatag ttaggacagc tctattctga gaaatctgag ctatcaatgc
    25801 ttcagaatag tatttcgcca atggttttta ttgaagaggt gattgtgtta tgatagtcta
    25861 aaataaaatt gatttaatag agtaaatgga gaatcgttac atgaaacatt tttttgcagg
    25921 aattggtgag ataaaacttg ttggctactt attgtatata tgtgtaggac tagcccctct
    25981 ttttcatata tatgtcatag gttcggaact gagttttgtg aaaatagtgt tatctatttt
    26041 gggagttata tttgtaagta tgttaactat tgctcgaatt tataggactt ttttctataa
    26101 agaatagttt ggacttgaac tgtatctaaa aacagaggtt ggtcgattat cagcctcttt
    26161 cttgtcgttg aaaagagtga gatatattga cttttgaaaa aaagatgtca taattgagtt
    26221 gggataaacc taaaagtaat atagtagatt gaatctggaa tagtccgtta tgactgttaa
    26281 aatatttcta gaaattaatt tgactttcct aatcgatttg ttcacatctt gtttcaatct
    26341 actatacttt ctcgttaaac cgttcggcaa ttcatggtga catggacaca tggtagtaag
    26401 cacactatgt ggcttggcag agctaaaaac tgttcccttg cgataagcct aataagcaca
    26461 acatagggag ttagagaagc cgactctaat caaccacttt gggcagtagt gagaactgcc
    26521 ccgtgctttt tattttgaga aaatatggag tttgtcgttg aaattacttg attgtatttt
    26581 ggattatcaa gaaagattca atggaaaaac atgtcaagta tcaacgaatt ataagtattt
    26641 agagactttc aaagtgaatt tttgcttgac tgatttacat catttatttg gcttatacaa
    26701 aatcacacga gattatgcta gtcaaacaaa acctgctatt caagctggtg tttttatttt
    26761 agaagatttt agaaatatcc tatgtacaat gatgtaatcg aaaggatatc tttatatgag
    26821 tttatcggcg ctatcttcta ttctaagcta acaagttgtt gcatcgtagc taaggattta
    26881 tctaaaaata ctatgaaatt ggacgtcata ttttttgagg ataaaaataa aagatccgca
    26941 gttttaggtt tacgaagaga caaaagcgga gtatttaaac cagttactct acattttaca
    27001 agcgctaaga aatatgctaa agttcgtaaa acagatgtga aagaaatgaa atggctataa
    27061 agattgtccg caggcttaag cttgcgtttt ttgttgttta acgaaattaa aaaacaagct
    27121 ctctcatcgg aagtgttttt ataggaatga aggaagatga tgctatgttt aaaaagagaa
    27181 tcgaaaaggg caaaagtagt gtctttatct ttttggagta gaagcttatg atatagaaat
    27241 ttgtaataaa aatgtaatat aaaacatttg acaaatattt acggggggac tatacttaat
    27301 ataagtatag tctaaaaatg actatcagaa aagaggtaaa tttagatgaa taagaaaaaa
    27361 atgattttaa caagtctagc cagcgtcgct atcttagggg ctggttttgt tgcgtctcag
    27421 cctactgttg taagagcaga agccgctcca caagttgtcg aaaaatcttc attagagaag
    27481 aaatatgagg aagcaaaagc aaaagctgat actgccaaga aagattacga aacggctaaa
    27541 aagaaagcag cagaagctca gaaaaagtat gaagatgatc agaagagaac tgaggagaaa
    27601 ggcgcgctag aagaagaaac ttctaggaag gtaaacgatg ctactttaga ggtacaaaac
    27661 gcatatgtag aatatggaga agctaataag aaaaaaggta aggaccgtga gaaaaaatta
    27721 gcagatgcgc aaaaaaaaat agatgaagcg caggaaaaac taaccaaagc taaaaatgag
    27781 tttcaatctg ttcgagcaat ggtagttcct gagccagagc agttggctga gactaagaaa
    27841 aaagcagaag aagctaaagc agaagaggca gtggctaagg aaaaatctga taaggcagct
    27901 aaagaggtag aagtagcgaa aaaaagagta gaggcagaag aagctgagtt ggataaaaaa
    27961 gttgctgaac ttcaaaataa agttgctgat ttagaaaaag aaatagctga tgctgaaaaa
    28021 acggtagcag atttagaaaa agaagttgct aaacttgaaa aagatgtaga agatttcaaa
    28081 aactcaaacg gtgagcaagc tgaacaatac cttgctgcag ctgaaaaaga cttagttgct
    28141 aaaaaagctg aattagcaga agctaaaatt aaagctgcta ctaaaaaagc tgaattagaa
    28201 cctgaattag aaaaagcaga agctgaactt gaaaacctat tatctacact agaccctgaa
    28261 ggtaagactc aggatgaatt agataaagaa gctgctgaag ctgagttgaa taaaaaagtt
    28321 gaagctcttc aaaaccaagt tgctgaatta gaagaagaac tttcaaaact tgaagataat
    28381 cttaaagatg ctgaaacaaa caacgttgaa gactacatta aagaaggttt agaagaagct
    28441 atcgcgacta aaaaagctga attggaaaaa actcaaaaag aattagatgc agctcttaat
    28501 gagttaggcc ctgatggaga tgaagaagag actccagcgc cggctcctca accagaaaaa
    28561 ccagctccag ctcctgcacc aaaaccagag caaccagctc cagcaccaaa accagaaaaa
    28621 acagatgatc aacaagctga agaagactat gctcgtagat cagaagaaga atataaccgc
    28681 ttgccccaac agcaaccgcc aaaagcagaa aaaccagctc cagcaccaaa accagagcaa
    28741 ccagttcctg caccaaaaac aggttggaaa caagaaaacg gtatgtggta cttctacaat
    28801 actgatggtt caatggctac aggttggctc caaaacaacg gttcatggta ctacctcaac
    28861 agcaatggcg ctatggctac aggttggctc caatacaatg gttcatggta ttacctaaac
    28921 gctaacggcg ctatggctac aggttgggct aaagtcaacg gttcatggta ctacctcaac
    28981 gctaatggtg ctatggctac aggttggctc caatacaacg attcatggta ttacctaaac
    29041 gctaacggcg ctatggcgac aggatggctc caatacaacg gttcatggta ctacctcaac
    29101 gctaacggtg ctatggctac aggttgggct aaagtcaacg gttcatggta ctacctcaac
    29161 gctaatggtg ctatggctac aggttggctc caatacaacg gttcatggta ctacctaaac
    29221 gctaacggtg ctatggctac aggttgggct aaagtcaacg gttcatggta ctacctcaac
    29281 gctaacggtt caatggcaac aggttgggtg aaagatggag atacctggta ctatcttgaa
    29341 gcatcaggtg ctatgaaagc aagccaatgg ttcaaagtat cagataaatg gtactatgtc
    29401 aatggtttag gtgcccttgc agtcaacaca actgtagatg gctataaagt caatgccaat
    29461 ggtgaatggg tttaagccga ttaaattaaa tcatgttaag aacatttgac attttaattt
    29521 tgaaacaaag ataaggttcg attgaataga tttatgttcg tattctttag gtacctatct
    29581 tatgatttca ggaaatgtca ttaaaaaaac gactcctttt ctctaacttg aaaaatagat
    29641 tagagaaaat gggttgtttt atttattata gttatttgaa tgaagataag aagaaggtat
    29701 actcacatca ttcacataat ctgtatgttg actataagtt ttaaaaaaca atttttaagc
    29761 tcttccttgt cttctccaac caagcgtgtt ataatgaata ctgctcaagc gaccttcaat
    29821 cgtgaagcac acacgacctt caatcgtgaa taaacgaata gatgggagac ttaccatgag
    29881 tgataactct aaaacacgtg ttgtcgtggg gatgagtggt ggtgttgatt cgtcggtgac
    29941 ggctcttttg ctcaaggagc agggctacga tgtgatcggt atcttcatga agaactggga
    30001 tgacacagat gaaaacggcg tctgtacggc gaccgaagat tacaaggatg tggttgcggt
    30061 ggcagaccag attggcattc cctactactc tgtcaatttt gaaaaagagt actgggaccg
    30121 cgtttttgag tatttcctag cggaataccg tgcagggcgc acgccaaatc cggacgttat
    30181 gtgcaacaag gaaatcaagt tcaaggcctt tttggactat gccatgacct tgggggcaga
    30241 ctatgtagcg actgggcatt atgctcgagt ggcgcgtgat gaggacggca ctgttcacat
    30301 gcttcgtggc gtggacaatg gcaaggacca gacctatttc ctcagccaac tttcgcaaga
    30361 acaacttcaa aaaaccatgt tcccactagg acatttggaa aagcctgaag ttcgaaaact
    30421 agcagaagaa gcaggccttt cgactgctaa gaagaaagac tcgacaggga tttgctttat
    30481 cggagaaaag aactttaaaa acttcctcag caactacctg ccagctcagc ctggtcgcat
    30541 gatgactgtg gatggtcgcg atatgggcga gcatgcaggt cttatgtact atacaatcgg
    30601 tcagcgtggc ggactcggta tcggtgggca acacggcggt gacaatgccc cttggttcgt
    30661 tgtcggaaaa gatctaagca agaatattct ctatgtagga caaggattct accatgattc
    30721 gctcatgtca actagcctag aagccagtca agtccacttt actcgtgaaa tgccagaaga
    30781 gtttacgcta gaatgtacgg ctaaattccg ttaccgtcag cctgactcta aggtgaccgt
    30841 ccatgtcaaa ggagacaagg cagaggtcat ctttgcggaa ccacaacgcg cgattacacc
    30901 aggacaggca gttgtctttt acgatggcga agagtgtcta ggtggtggtt tgattgacaa
    30961 tgcttaccgc gatggacaag tttgtcagta catttagatt gacaaatttt ctcaatttgc
    31021 tacaataata acagcaatag aaatgatggt caaagctcat ggatgttgca ggcttttttg
    31081 tcctgcactt ctttgtagtt ttgactgttt ttgtgtcgtt taagggaaag gacaagaatg
    31141 actcaacaag actttcggac aaaagtagac aatacggttt ttggtgttcg ggcgacagct
    31201 ttgattcttc aaaatcgcaa gcttctagtc accaaagaca agggcaagta ttacattatc
    31261 ggcggtgcga ttcaagttaa cgaaaaaacg gaagacgcgg tagtccgtga agtgaaggaa
    31321 gaactgggta tcaaagctca agctgggcag ctagcttttg tggttgaaaa tcgttttgaa
    31381 caggacggtg tttcctatca caatatcgaa tttcattatc tggtggactt actggaggat
    31441 gccccattga ccatgcagga agatgagaaa aggcagccct gtgagtggat tgacttggat
    31501 aagctccaga atatccagct agttccagcc tttttaaaaa cagccctacc agattgggaa
    31561 ggccaactaa gacacattca tcttgaggaa taggagagaa acatgactta tcattttact
    31621 gaagaatacg atattattgt aattggtgcg ggacacgctg gggttgaggc ttccttggcc
    31681 gctagccgta tgggctgtaa ggtcctgctt gcgaccatca atattgaaat gctggctttc
    31741 atgccttgta atccctctat cggtggttct gccaagggga ttgtcgtgcg tgaagtcgat
    31801 gccctcggtg gcgagatggc caaaaccatt gacaagactt acatccagat gaagatgcta
    31861 aacacaggga aggggccagc tgtccgtgcc cttcgtgcgc aggctgacaa ggaactttac
    31921 tctaaggaga tgcgcaagac ggttgaaaac caagaaaatc tgacccttcg tcaaaccatg
    31981 attgatgaga ttttggtgga agatggcaag gttgtcggtg tgcgtacagc cacccatcaa
    32041 gaatatgctg ctaaggctgt tattgtgacg acagggactg ctctccgtgg ggaaattatc
    32101 atcggagacc tcaagtactc atcaggtcct aaccacagct tggcttctat taacctagct
    32161 gacaatctca aggaactggg tctcgaaatc ggtcgtttca agacaggaac ccctccacgc
    32221 gtcaaggcct cttctatcaa ctacgacgtg acagaaatcc aaccaggaga tgaagcgcct
    32281 aatcacttct catacacttc acgtgatgag gattatgtca aggaccaagt gccatgctgg
    32341 ttgacctata ccaatggtac cagtcatgag attattcaaa acaacctcca ccgtgcgcct
    32401 atgtttacag gtgtggtcaa gggagtgggg cctcgttact gtccgtcgat tgaagacaag
    32461 attgtgcgct ttgcggacaa ggaacgtcac caactcttcc ttgagccaga agggcgcaat
    32521 actgaggaag tctatgttca aggactttca accagtctgc ctgaggatgt ccagcgtgac
    32581 ttggttcatt ccatcaaagg tttggaaaat gcagagatga tgcggacagg ttatgctatt
    32641 gagtatgata tggtcttgcc tcatcagttg cgtgcgactt tggaaaccaa gaaaatctca
    32701 ggtctcttca ctgctggtca gacaaatgga acatcaggtt acgaagaagc tgctggccaa
    32761 gggattatcg cgggtatcaa tgcggctctg aaaatccaag gcaagcctga attgattttg
    32821 aagcgcagtg atggttatat cggggtgatg atcgacgact tggtgaccaa gggaaccatt
    32881 gaaccctacc gtctcttgac cagtcgtgct gaataccgtc tcattcttcg tcatgacaat
    32941 gctgatatgc gcttgactga gatgggacgc gagattggcc ttgtggacga tgaacgctgg
    33001 gctcgttttg aaatcaagaa aaatcaattt gataatgaga tgaagcgcct agacagtatc
    33061 aaacttaagc cagtcaagga aaccaatgcc aaggttgagg agatgggctt caaacccttg
    33121 accgatgcag tgacagccaa ggaattcctt cgccgtccag aagtttctta ccaagatgtg
    33181 gtggccttca tcggaccagc tgcagaagac ttggatgaca agattatcga attgattgaa
    33241 acagaaatca agtatgaagg ctatatttcc aaagccatgg accaggttgc caagatgaaa
    33301 cgcatggaag aaaaacgcat tccggccaat atcgactggg atgacattga ttctatcgca
    33361 accgaagccc gtcagaagtt caaactcatc aatccagaaa ccatcggcca agccagccgt
    33421 atttcgggag taaacccagc agatatttct attttgatgg tgtatctgga aggtaaaaat
    33481 cgtagtattt ctaaaactct tcaaaaatca aaatgatacg tcgtcggctt cttacgaatg
    33541 agttcaaagc ttggctttga ttcatctcca acctcccata gttccccgaa ctatgggagc
    33601 taactcaagt tatgcatttt cctagccttc tagtctgatt ttcattgagt tttaatctca
    33661 aaagaaagca tagagaaaaa cagctccgag gacggggctg ttttcttgct ttattcttca
    33721 tctggtgtga ggatcatcgg gatgatgatc ggttcacgtt cggtattttc atagaggaag
    33781 gggcgaatag cgttgacaat ggcaccattg acagattgca cgctagcatc cttatttttc
    33841 agtgcgatac gaatggcatt gaagaggata cgctggcttt ggcgaatcaa gtctccagac
    33901 tctctcatgt agacaaagcc tcggctgagg atatctgggc cagacagaat catctgcgat
    33961 ttgaagtcaa cagttgcgac tgccagaacg acaccgtctt cagatagatc gcgacgatct
    34021 ttgaggacag ctgcgccaat ttcaccgata cgatttccat cgacatagat atcttgggcg
    34081 ttgaaatgac ctgcgatacg agctgagtca gcagtaaggg caagcacatc gccattgctc
    34141 atgataaaga tattgtcctt ctcaacacca gtatccactg ctagtccagc gtggactttt
    34201 tgcatacggt attcaccgtg gacaggcatg aagtattttg gcttaatcaa gcggagcatg
    34261 agtttttgct cttgctgacc accgtgtcca gatgtatgga tattgttcac tttaccgtgg
    34321 ataacttcga caccagcttc agaaatgatg ttaatcagct tgttgacgct agtagtgttt
    34381 ccagggatgg gactagaaga gaagataacg gtatcacctg gttgtaattg tacttgacgg
    34441 tgggttccgt tggcgatacg agagagggct gccataggct caccctgact acctgtacag
    34501 aggataagaa cttctcctgc aggataatct ttgatttcat ttggctcgat aaaggttccc
    34561 ttaggagctt tgatgtagcc aagatcgatt ccgttgacaa tggccttttc catagaacga
    34621 ccaaagaccg caatcttgcg tccagtctta acagcagctt ctgttgcctg ctggagacgg
    34681 aagatatttg aggcaaagga tgcaaagatg atacgtcctt caataccttg gataatcttc
    34741 ataatggact gaccaacgac tttttcagag ttggtaaagg ttggtacttc cgcatttgtc
    34801 gagtcagaca ggagacagag cacaccttct tcaccaagcg cagccatacg atgcaagtcc
    34861 gcaggttctc caactggagt aaagtcgaac ttaaagtcac ccgtacagac gattttccct
    34921 tgaggagtat gaatgacaat ccccaaaggc tctggaatag agtgagtcgt tctaaagaaa
    34981 gttgccttga gatttttaaa ggtcaactcg gtgttgtggt tgatttcgta aagtttggcg
    35041 ttgcgcaaga ggccgtgttc ttcgagtttc ccacggatca aagccaaggc aagcggtcca
    35101 gcgtagatag ggacatttgc ttgcttgagt aggaacggaa tcccaccaat gtggtcctcg
    35161 tgtccgtgtg tgattaaaac agccttgacg cggtcgatat tgtccacgat gtaagagtag
    35221 tcaggaatga catagtcgat accaagcaag tcatcttctg ggaatttaat cccagcatcg
    35281 acgatgataa tctcgtcttg gtattcaatt ccgtaagtgt ttttcccgat ttctcctaga
    35341 ccaccgatgg caaaaacgcc gacttcttca ggtttaagag tgtaggccat attagaactc
    35401 cgtaatttcg aaggcgccag tttctttttc gtaatcgagc aatttgtcag acaagagttc
    35461 gatatattcg atattgtact ctgggcgatt ttcttcgaca agttggcgag cagtgatacg
    35521 gccctcaagt tctgagctgg catcgatgtc taggtaaagc gcgcgtgttg tttcacggcg
    35581 tgggctacgt tcttttgttt cttgataaaa aactttgtaa atcatatagt tcctttctat
    35641 ttacaggtca gcttattcca aacttttagc agatatttgc ttgatttcat tccattttgt
    35701 gtctagattg accttgattc gttacaatta tttcaattat accacaaaat gaaaaattag
    35761 taaaagacgg aaacgagaaa gttaggggac gatttcttcg gtaagcgttt gcaaaaataa
    35821 agaaaatgtg ttatgttgat aacggaagtg aagtttatta cttgtcataa ttccatatag
    35881 attttaagtc aaggaggttg ccctatgtat aacttatttg cttttgctat cggagttcgt
    35941 ttgttagctt ttatcgtttt tgttgcttgc gtttatggag gaaatcttct atttgccaaa
    36001 ctggaacgat gacaaaccaa gttcttgtgg aaaatgacct ttgtgactct ctactcgctt
    36061 cttctcctcc tcatgaccta tgtcgtttgg tttgtatttt actttggatt aaatgcttag
    36121 atgccctgct tatgctgggg ttttttgttt ggggatgtag agatagtaga tttacgacac
    36181 gaaaattcca ccccatctat caagatgagg tggtctttgc atttttctaa aatgacatga
    36241 caatggaatt ttcaaagctt attattttta tgggagtcat tgttctgctc aaaaatagag
    36301 ttgaagcata aaaataaaac aatacaaaca gataaatcga atggtaaagg gatagtagta
    36361 atgttcaaat cattgagaat gctgagcaaa ctgtaagaga tgaagacaat aaaatttata
    36421 cttctaaaaa tgtgtttctt atctagcatg atttaccaaa ctttttacga aggtcttttc
    36481 caatggtata acctgccata aataaagcga taccaacacc tacaccaaag ccacccttga
    36541 tttcttgcaa ttccttatta gaaatttcac gatagttgtt caaatctttc atcatattaa
    36601 tctcctccta aaaaataacc agctgccaaa ccagaaccta taagtgctgt tccacctgca
    36661 atagccttcc aagatactgc tactccaaag ataaccaagg gagcgagacc gccatcaata
    36721 tctgataatt cattttcaga taaggataaa aattgattgt caagaatgtc aaaatttgtc
    36781 attgaacttt cctccttttt tcttgttcac ttttatattc ggaaaagaaa aggaaaagtg
    36841 agcatttttt taaattattt ttagttaagt gagggcactc ttgtctgggg gcaaagaaaa
    36901 ttcccatgtg ccagcttttg tagtataata gtaagcagac aaaaagatag gaatgtgtta
    36961 tgaaagtatt agcttttgat acgtccagca aggctctttc tctggctatt ttagaggata
    37021 agcaggttct tgccgagacg acgattaata ttaagaaaaa tcacagtatt actcttatgc
    37081 ctgccatcga ttttttgatg gcaagtttgg attggacacc caaggatttg gaccgaatcg
    37141 tggtagctga agggccgggt agctatacag gcttgcgaat tgcggtagca actgctaaga
    37201 ccttagctta caccctgaac atcgagttgg ttggtatgtc gagtctcttg gctctggtgc
    37261 cccaccaaca agaaggtttg tttgtcccct tgatggatgc gcgtcgcaat aatgtttatg
    37321 caggatttta tgaaaatgcc aaacctgtca tggcagaagc gcacctatct tttgaagagg
    37381 tgctagaaaa agtcaagggt actagtcagg taacctttgt cggagaagtt gccccctttg
    37441 tggagcagat tcaagaatac ttgccaagga ctaatttcaa agaaaccttg ccaaatgcag
    37501 ccaatcttgc tcttttagct tgggacaagg aagcagactc cttgcatgat tttgtgccga
    37561 attatctcaa acgtgttgag gctgaggaaa actggctcaa gaaccacaca gagtctggcg
    37621 agtcttacat taaacgccta tgatagaaat caaacgaatc caacagcgac ctgacttggc
    37681 tcaagccatc tacgctgtta tggtagctgt ttacccagtt agtccgtgga cgctggaaca
    37741 aatccaagca gacctgtccc aagaccagac ttggtatgtt ctggcttatg atggggcaga
    37801 agtgattggc tttctagctg ttcaggagaa tctttttgag gcagaagtct tgcaaatcgc
    37861 tgtcaaagaa gcctatcagg gtcagggaat tgcgtcagcc ttgtttgctc aattgccgac
    37921 agacaaggaa attttccttg aagtcagaca gtcaaatcat cgagcgcaag cattttacaa
    37981 gaaagaaaaa atggcggtca tcgctgatcg aaaggcctac taccatgacc cagtcgagga
    38041 cgccattatc atgaagagag aaatagatga aggatagata tattttagca tttgagacat
    38101 cctgtgatga gaccagtgtc gccgtcttga aaaacgacga tgagctcttg tccaatgtca
    38161 ttgctagtca aattgagagt cacaaacgtt ttggtggcgt agtgcccgaa gtagccagtc
    38221 gtcaccatgt cgaggtcatt acagcctgta tcgaggaggc attggcagaa gcagggatta
    38281 ccgaagagga cgtgacagct gttgcggtta cctacggacc aggcttggtc ggagccttgc
    38341 tagttggttt gtcagctgcc aaggcctttg cttgggctca cggacttcca ctgattcctg
    38401 ttaatcacat ggctgggcac ctcatggcag ctcagagtgt ggagcctttg gagtttccct
    38461 tgctagccct tttagtcagt ggtgggcaca cagagttggt ctatgtttct gaggctggcg
    38521 attacaagat tgttggggag acacgagacg atgcagttgg ggaggcttat gacaaggtcg
    38581 gtcgtgtcat gggcttgacc tatcctgcag gtcgtgagat tgacgagctg gttcatcagg
    38641 ggcaggatat ttatgatttc ccccgtgcca tgattaagga agataatctg gagttctcct
    38701 tctcaggttt gaaatctgcc tttatcaatc ttcattacaa tgccgagcaa aagggagaaa
    38761 gcctgtctac agaagatttg tgtgcttcct tccaagcagc agttatggac attctcatgg
    38821 caaaaaccaa gaaggctttg gagaaatatc ctgttaaaac cctagttgtg gcaggtggtg
    38881 tggcagccaa taaaggtctc agagaacgcc tagcagccga aatcacagat gtcaaggtta
    38941 tcatcccccc tctgcgactc tgcggagaca atgcaggtat gattgcctat gccagcgtca
    39001 gcgagtggaa caaagaaaac ttcgcaggct gggacctcaa tgccaaacca agtcttgcct
    39061 ttgataccat ggaataaaga gtggctcttt gtcaagtgta gtgggtaggc gaaaagctac
    39121 aatctggaga gtacgaaatt cgtactctct tttttgatgt tcaaagtcat caaaatccgt
    39181 tttttaaaat tgttaaagtt ccggaaacca aaggctttgc gcttgataac cttaataaaa
    39241 ttattggtcg cttcaagttt agcgttggaa taaggcagct taagtgcgtt gataatctta
    39301 tctctataga aatggttggc attcttctct tgaaaatgaa agagcaggag ttgatagagt
    39361 tcgtagtgaa tctgtaatcc ctcagagtaa gaaagcagct tatctcgtac ttcccgatgg
    39421 gttaagtgca ttcgaaacgt gggctgatag aatcgtttct gacagagctt gaagctatcc
    39481 tggtgtagta aatcagtcca gtggactgat ttagcccgag cctagaaacg aaaaagcgag
    39541 ggttccaaaa gcgcttgagc gcccgatact ccaaggattt tcggtcaaat tggttcatga
    39601 tttggattcg tactcggttc atagctcggc tcagatgttg gacaatgtgg aggcggtcaa
    39661 gaacaatctt cgcctttgga aagagttgct tagcgagccg ataataaggg ctgtacatgt
    39721 ccatggtgat gacctcgacc agctcccgaa cctctctctg atagcgttgg aaatggtttc
    39781 gaatcaccgc atgagttcgc ccgtctaaaa ttgcgaggat ggatttggac tcaaaatctt
    39841 gggcaatgaa gctcattttg ctctttttga agctatactc atcccaactc ataacttttg
    39901 gcaacttggt ccaatcggtt tcaaacttaa attccctcag ttttcggatg acggtggaag
    39961 ttgagaccgc caatctgtgg gcaatctcag tcatagactg cttttcaagg aggagctgag
    40021 cgattttttg tctcaccatg ttggaaatct ggcaattttt cttgacaatg gatgtttgag
    40081 aaacgaccac cttaaggcaa ttcttgcact gaaagcggcg ctttttgaga tgcagtaccg
    40141 tgggtaaacc ctgacagtcg agaagcggaa ttttagaggc tttctggaag tcgtatttga
    40201 tcatcttccc ttgacaatga ggacaaggag gagcggggga atccaacttt gcctgaacga
    40261 ctagatgggt ttggtatttc agaacagaca agattttgat atttttgtct tccaatccga
    40321 gcaaatctgt ggtattctta agttgttcca tatgacccct ttctaatgag ttggttagac
    40381 gcttttcatt ataggtcata tggggctttt tttctacaag aaacgaccct ataattcctg
    40441 gggtgggatt acccactaca gaaattatag agcccaaaca ttccaaagtc ttgtctgact
    40501 ctggaatgtt ttctgttcac agttgttttg taactgccta ataagtaacc gcgctataac
    40561 gaggtatcta ccgagattgt caattctcca gtatactgtt ataaaaaaca aaactggagg
    40621 attttttatg tccccccatc gtcccatcga ctgttccgta gctgcccaat aacggagtat
    40681 agtcggctga aacaagaata ggacaaaagt gcctcaagaa aagcatcgta atttgacaat
    40741 attattctga gatgtttttg atgtaagccc atattttctc aatgggatta tactcgggtg
    40801 aataggtagg aagtggtaac agtctatgct ctgctcctta cacatgttca ttctgtgaaa
    40861 ccttgcattg tccataatga taagggatgg tgtatctaaa gtaggtagta agaatttttg
    40921 gaagcaagct tcgaaaaagt cactcgtcat cgtatcttta taggtcatcg gagccatagt
    40981 atattgaaac aaaaaagggc attagtactt ctataacagt atcgcaatct ctggtgtgcg
    41041 ttgtctcgat cttaattcaa ataattatat cttcttccag agagactaac tgcctgctca
    41101 aggctcgatc atattcgaga taaaaatagg tcttaacccc tgtctcataa atataaatag
    41161 gagtcaggta gcttaagtga ttcaattctt taaggaaccg atttactttt tctgggtctt
    41221 gttcgcagta ggtacagctc ttttttagac tatatcccat agcctttaga gcgtaatgaa
    41281 tagttgttgg aggacagttg aattcagcag ctatttcagt caaataagca tcgggatgag
    41341 tttcaatata gatctttaat ttatctctat caactttttc aattaatagt ggaagttttc
    41401 ttaaagttag tgtattgaaa cgtttttata cagtgctaaa atttgaagtg tagtgcagat
    41461 atatttgtaa tggtattata gcaattcttt gaagaaggtc gagacaggag aaaataggta
    41521 tctttgagat ataagcatga tttactataa aattattgag ttattcataa aaatttctct
    41581 atcaaatatc ataatgcgtc gtttaaggag atggttacaa tgcaatatag ttgtggaaaa
    41641 ataaatatta atatccctga tggatatgga gacattaagg atatagtgtt ttcggctcat
    41701 attatagtta ggtataataa tggacattgt ggaggtatag atccgcatat aattggactt
    41761 tgtaaaaagc agatcagaag gatgtctcta tatcctattt tgataatcgt atctagagat
    41821 tcaaaggtta ttgatgatta taaaaattta gatattgcct atgttgattg tactcaatgt
    41881 tcaaataatt ttgaaactgc cttacacgtt aaaaatattt taaaattatt aaaaatccaa
    41941 cttatacact gtcatggcta ctcaactaat tattttttat atatgttaaa aaaacttgac
    42001 aagaatggat ttggaaaggt taagacagtg ataacatgcc atggatgggt tgaatataac
    42061 ttaaaaaaga aattcttgac ttattttgat ttttggacat attctatggg agatgctttt
    42121 atttgtgtat ctgaaactat gaaaaaaaag attggagagt ataataaaaa ataagaagat
    42181 agttgcaata aataacggaa ttaatgtatc aaatagcgat ttagatgtag taggtgttca
    42241 agactttaaa aaagaatttt gtattccaaa taacaaaaaa atcatttgtt atgttggaag
    42301 gttggatcca gaaaaaaggc cggatagatt ccttgaattt gcagaaaaat tatttttagt
    42361 cagagaagat gtgattttta ttatggctgg aaatggtagt atgtgggctg ctttgaaaga
    42421 aaaaatttgc catttgaaat gtagagataa tttcaggtta cttggtgaaa tctatccagc
    42481 tactatagtt taccaaatat cggatttatt gtatattcct tctgatacag aaggaatacc
    42541 tatgtgtgtt ttagagtcaa tgtcacaagg aactccggtt ttagctagta atgttggcgg
    42601 gttaagtgaa attattgaac atagggttga tggattttta tttgagaagg aagatgttga
    42661 gggagtgtgt gcttgtgcta attttttact caatgattct gagtatttga aatatatagg
    42721 tgagaatagt aaatcaaaaa taagaaaaca tttttctgtg caaaaaatgt ttgtagaaac
    42781 catgagagta tatgatgaat tattagagaa gagtagtcat ggataggaat atagatcaag
    42841 aattagtaag tattataata ccaacacata ataggtatga atctctgatt agagctgtga
    42901 aaagttgttt acatcaaagt tataaaaata tcgaagttat aattattgat gataattata
    42961 gtaatgtaaa tttaagaaat aaaattatcc atcaatttgg ctataccaat catagaatta
    43021 agttaatttt aagtaatgaa gatttaggtg caactaatgc cagaaacata ggtatcaaaa
    43081 attctagagg taagtatata tcatttttag acgatgatga tgaatatatg ccagatcgaa
    43141 ttttaaagtt gatggcttgt tttaaaaaga gtagaatgaa gaatttagct ttagtttata
    43201 gttatggaat aataatttat ccaaatggta cacgagaaga ggagaagacc gattttgttg
    43261 gaaatccctt gtttgttcaa atggttcaca atatagcagg tacgtcattt tggttgtgta
    43321 aaaaagaggt gctagaatta attaatggtt ttgagaaaat agattcacat caggacggtg
    43381 ttgttttatt aaaactactt gctcaaggat accaaattga tatagtgcga gaattcttgg
    43441 tgaattacta cgctcacagt aaagaaaacg gtatcactgg agtgacacaa aaaacaatta
    43501 atgcagatga agaatattat aattactgta ggaaatattt taatttattg agtttcaacg
    43561 agagaatatt ggttacaaag aaatattatt ctttaaacat aaagcggtta ctattaatag
    43621 gagacaaatg caaggcttta aaagtaatca agaaggcaag agaagaaaaa atttttaacg
    43681 aatttttttg aaatatatgt tattatatca ttttggtttt ttctattgta tatatgacaa
    43741 ctatgttcaa ttaaaattta gaaagtgaga aactattgtg tatactatta taaaatcaaa
    43801 tataaaaaaa tttagtttat taacgatatt tattgttgct ggtcaattat tgctaattta
    43861 tgcagcaact attaatgctc tggtgttgaa tgaattaatt gcgatgaatt tagagcggtt
    43921 tttgaaattg tcaatctacc aaatgattgt ctggtgtggg ataatattcc ttgactgggt
    43981 agtgaaaaat tatcaggttg aagtgatcca agagtttaat ctagagattc gaaatagagt
    44041 tgccacagac atctctaact ctacctatca agaatttcat agtaaatcat caggaacata
    44101 tctttcgtgg ctaaataatg acgttcagac tttaaatgat caggctttta aacaactttt
    44161 tttagtaata aaaggaattt ctggtactat atttgcagtt gtgactctta atcactatca
    44221 ttggtcattg actgtagcca ccttgttttc attaatgatt atgctacttg taccaaaaat
    44281 ctttgcatcg aaaatgcgag aagttagtct aaatttaact aaccaaaatg aagctttttt
    44341 aaaatctagt gagactatat tgaatggatt tgatgtgtta gcgtccttga atcttttata
    44401 tgtattgcct aagaaaatta aagaagcagg aattttatta aagatggtta tacaaagaaa
    44461 gacaactgta gaaacgttag caggcgctat tagcttcttt ctcaatattt tttttcagat
    44521 atctctcgtt tttttaacag gctatcttgc aataaaagga atagtgaaaa ttggtactat
    44581 tgaagcaata ggagcactaa caggtgttat ttttacagcg ctaggtgaat taggaggtca
    44641 attatcctct attattggta cgaagcctat ttttttaaaa ttgtattcaa ttaatccaat
    44701 tgagtcaaat aaaatgaatg atatcgaacc aaatgaggtg aatagagatt ttccgttata
    44761 tgaagcaaaa aatatttgct ataagtatgg agataaagaa atattaaaaa acttaaattt
    44821 ttgttttcaa cgtaatgaaa agtatttaat tttaggtgaa agtggaagcg ggaaatctac
    44881 attattaaaa ttattgaatg gctttttgag agattatagt ggagaattgc gattctgcgg
    44941 ggatgatata aaaaaaacct cctatttaaa tatggtttcg aatgttctat atgtagatca
    45001 aaaagcttat ttgtttgaag gtacgattag agataatatt ttattggaag aaaattatac
    45061 tgatgaagaa atactacagt ctttagaaca agttggtttg agtgtaaaag attttcctaa
    45121 taacatttta gattattatg ttggtgatga tgggagatta ctgtcaggag ggcagaaaca
    45181 aaaaattact ttagctagag gcctaattag aaataagaaa atagtattaa ttgacgaggg
    45241 aacttctgct atcgatagga gaacttcgtt agcgattgaa cgtaagatat tagatagaga
    45301 ggatttgact gtcattattg ttacccatgc tccgcatccg gaacttaaac aatattttac
    45361 taagatatat caatttccaa aggattttat ttaagaatat aggggaggga aacatgagat
    45421 tctattgtga agcttatgag gtaattactg aagagaaaaa agtatcattt ttttatgtag
    45481 atgaaaaacc cttaaggtat ctgttatttg actatatatt tctactagtt ctagctaaaa
    45541 aaatatccca atcttatgaa ctgcacccca aaagttagat ttattctgtc taacttttgg
    45601 ggtgcagttc attttgcata gttttggcat tcatcctaga tatccatata aaatgtctga
    45661 gattgttgaa atgtctaaaa aaatatcaga tctaaacgat aaaaaagaat ttcacaaaaa
    45721 gaactgtgag ttgaggtttc aagatagtgt tcttgataac ataaatagtg tcccgggtac
    45781 aactcattta tttagttgtt taaatattca aatattagta aaaattattt tatatatttt
    45841 tcgatacaac agttgtatga aaatatttaa ttttagagat aaagagctta tcttttttaa
    45901 taagattgta aatgggctga tacaaaatat tgaggagaat ttagaggatg atattgaaag
    45961 gatattgaaa tatttatata tatgtttatt taacgaaata ttcattatta agaataaggt
    46021 gaattttttt gatgatgtgg aatttaatca gacacttagt gagtttttag ataaattgta
    46081 gagggaatgg ttatgagtaa caatactaag tatatctttt tatctccaca tttagatgac
    46141 gcaatttttt cctgtggtga ttatatttca aaattaactt cagaaggaga aattgtactt
    46201 gttattacta tattttctgg ttaccctttg agccaacagc tacagtcctc tgctaagcaa
    46261 tttcataagt tgtgtaacct tgggaaatat ccgattgaag aaaggaagaa agaagacagg
    46321 ttagcttgtg aacgtctaca atgtgatttt agacacttat cgtactatga atgtctctat
    46381 aggaaagata gaaatggcaa ttttctatac cgtcatatct atagtgaatt aaaaaatgag
    46441 gacacattaa agaatgatat cataaaagag ctgttaatgc atttagacga caaatgtgtc
    46501 gtatattgtc cgctttcact tggtgaccat gttgatcatg tttttgtgaa tagtattgga
    46561 agggcgcttg aatttatgcg ttataaagta atatattatg aggatttccc atatgtaagt
    46621 gatagtagta tggttagtta tatgggaaaa actaaagaat taaaaatata tcaagaggaa
    46681 cttgataaaa aacattatat tgatagaata tcatcaatat tgtgctataa atctcagatt
    46741 ttgataatct ggaaatcagt tgaaaaactt ttaaacaata ttaaagagtt gtatttaagg
    46801 aatggggcag cttattctat tatattttgg attaagaaat aaggaagtag ttttatgaat
    46861 atagcagtaa ttggtttggg gcatgttggg ctggcctacg cgttactatt tgcatctaaa
    46921 tataaagttg ttgcatatga tatagattct gtaaaaataa ataatttaaa aaagggcatt
    46981 cttccatcta aaaatgaaga gcttatgaag tttttttgcg agaataactt aaatattact
    47041 ttttttgata cattttctga aattaaaaat aatattgatt attatattat tgcgcttccg
    47101 acagattatg atgagaaaat tggtagtttt aatacatatg aaatcgaaca aacggtatcg
    47161 aagattctga gggtaaaacc taatggaaag attattttaa agtcaacagt tccgatcggc
    47221 ttttcaaaca aattaaaaag gctgtttgat acaaaaaata tcatttttgt ccctgaattt
    47281 ttgagagaag gttgttctat atatgataat ttatatccaa gtcgcatagt tgttggagat
    47341 gagacagttg aaggaagaaa aattgcagag ttgttccttt cgattagtac tcatagtact
    47401 gccaatatta aaaatgttat gttagtttct cctactgaag cagaagcaat taagcttttt
    47461 tctaacacat tcttagctct ccgtgttgct ttttttaatg aactagattc ttttgctgag
    47521 aggagaagtt taaatgctga agttgtaata aaaggtgttt gtttagatcc aagaattgga
    47581 aatttttata ataatccttc ttttggattt ggaggatatt gtcttcccaa agatactaaa
    47641 caattaaaaa aagaatttat agaaataaat gccccagtga tagaagcgat tgatatttca
    47701 aacacaaata gaaaacagtt catagttaaa caaatattgg aacgaaagcc aaagatagta
    47761 ggaatatata aattggggat gaaatataat tcagataatt acaaagagtc agctatttta
    47821 agtataatta atgaactatt gattgtcggt ataaaaattt tagtatatga accaaattta
    47881 aacgttagta tagataacgt aatttttgaa aagaattttg aactatttac aaaacaaagt
    47941 gatctaattg ttgcaaatag atgggatagg ggccttgaag cttataaaga taaagtttac
    48001 acaaggggga tctggataag agattaacta ttgatattaa aaaggaaata atttataaaa
    48061 tttgtacaaa aaatgttaaa ttttcacatt ttcatagtat actgtttaat agaaagtagg
    48121 ttctttgtaa ccgctccatt ataaaatcct ttcactcttc cggtatacta ttaggaaaaa
    48181 cataactgga ggatattttg agctcacacc tcatcgttcc agtggctgtt ccccaagctc
    48241 gtgtactgcc caaaaaagtt agacattcta tttagaacga ggattgagtt ctgtattgta
    48301 caaggctcgg tccttttaga gtcagcttaa ggctggcttt ttcaatcacc aaagtgtcag
    48361 aatgttttga caaatgaaca caaataatga tataatatgc aaaagctagg aggtggtagg
    48421 atgattgaaa aaatggaact gggggaattt tacaaggaat tacgtttggc gagaaagctt
    48481 aagcagacag atgtggcttg tgagggtcta acagcttctc agttgtccaa gtttgaacta
    48541 gggcagtcta tgctgtctgc ggataagttg attctagcta tccaaggtat aaatgtgacc
    48601 tttgatgagt ttgggcacaa gctcaacaac tatcaagaat ctccacatat gcgaatcggt
    48661 cgaaaggttg tgaatcgctt tgcccatcag gatatagctg ctttagagca gctattggag
    48721 gaagtcgatc aagaacagat ggcgcagacc tatcgtcgtt tgaatgccat cgtgattaaa
    48781 gatgccatcc attcactaaa taaaagctac ccactagcag aggaggatag cgagtttttg
    48841 accacctatc tctatgctat cgagtcttgg acctggtttg aactctatct cttttgcaat
    48901 accatgccct tcttgagcaa tcaagatctg atttttttat caacctcctt actcgaaaaa
    48961 tccaaagaat ttaaagagtt agtatacaat cgattgtata tgaagcaagg actcttaaat
    49021 atcttatcag aactcatgga gcgaaaactt ttctcctaca tcccaatctt cgaagccgag
    49081 ttggagagga tgttacgacc gtatgatgtt tttgaaaaag tatcgtggca atttttaaag
    49141 aagatgagtg tctttcttca aacaaaggga agcaatcaaa aagagattga acgctttatc
    49201 caatctctgc aggtattaga aaatccacaa ttaacatccc tttttgaatt gcgttttcag
    49261 caatataaag aacttataga ttagttaaaa atggaatgac aataacccac tccgaaataa
    49321 gtaggagtat cagttggatt tttcttttct tcatctatta tattcctcct tgttagtaat
    49381 aactttatta taccagggaa ataatcaaat ctatcaaaat cgcaaataag aaatttctat
    49441 aagaaaaaat atcaaatatg cgatttttta aaataagcca attttcgtgt tatactgtac
    49501 ttgtaaagca cttgaagcaa atcctaggtc gcagaagtgg tttacaaatg aagataattg
    49561 aaggagtgta aaagatgtta aatttacaat ttgcagaaac aatggaattg acagaagctg
    49621 agttgcaaga tgttagagga ggcaacctcg taaattctat gggaggtggt ggaagaagtg
    49681 gtatatctgg ttggggcgtc ccaggaattt accctggttg gggcaatcaa gggatgagtc
    49741 ctaatcgtgg agcttttgat tggactatag atttagcaga tggattgttt ggccgccgta
    49801 gaagataggc tcttatagga gataatagga tgaagaaaat gaaagaagtg aaatttcacc
    49861 tagcaactgg cttgttgatt ttgacttatt acctcatttt taatgtcaca tcagacttag
    49921 attttatggt tgctttgtct gataatatgt actatgtgtt ccaagtttta ttggtactta
    49981 ttctgggaac tatagctaca attgcttttg tcaaaagtga acattggaaa gagtgtggtc
    50041 gtttccagtt tcgttggttt tacctgggtg ttttccttct ttcttttttc ttattgttcg
    50101 tgtgggcaaa tctaacaacc tatatctttc ctcgtaccca gaatggaagt acagtcgtag
    50161 aagtagccac caatttaaca ggaattagct attttgttac gcgaatactt tatactagta
    50221 ttatcgcacc tgtatcagaa gaggttgttt gtcgtggtct tttgatgaca agtttatcta
    50281 aagttaagag atactatctt gatgttcttg tttccgctgc catatttggc gctatgcatg
    50341 ttttgcagta tggttggata acgacagatt tcataaagta ttttggaatg ggcttgatat
    50401 tttgtatgat gtttcgctac acccgatcca tctattgggc tatagctctg catgcttcat
    50461 ggaatagttt cttactcatt gttactttat tggtatttgg atattagaaa ggtgatatat
    50521 gaaaaagata atctcacacc gctactttat tatagttttt ctactagtta ttgctgacca
    50581 gaagttcagt gttctagttt tacgcagcga ccttgttact gggctatctg actttgccta
    50641 ttatctgtcg gatatgatgt tgaattttct tgtggtttta tttgctctta ttgctatgat
    50701 ttggtcgggg aaatggcaga aaatcaatag tagaaagttt aaaggatcct atcttttcta
    50761 ttccttccta gctctgcttg cttttgttgt ttggaatttc gttacctttt ttcttttccc
    50821 acctactcga aatgaaattt cttatcaata tgctgctccg acttttacag gggctacagc
    50881 atttttgatg tattttttct atcctgtgat tgcaggtccc atttttgaag agataatcca
    50941 tcggggattg gtgatgacag ttctggaaaa aggaaagaaa tgggggctag atgtacttgg
    51001 ttccgctgtt ttatttgggg tctcgcacat tagtaatcac ggttgggtct tgacagactt
    51061 tgtcttctat atgggtggag gtcttatatt tgcagtctta tttagaatga caaagtcaat
    51121 ttattggcct attggactgc atatagtcta caatggcatt ggtcagcttt tgatgttact
    51181 gtaattttgg ttgttagtag tatcgcggtc tatccttggg gaaagcttcc catttgaact
    51241 taagaaggag ttgtgatgaa agtatttctt caaaatagag attttaggca attaactatc
    51301 aaccagtgga tttcaacgct tggggatacg attttttatc tggccttcct gaattatgtg
    51361 gcagatgcat cttttgcccc tttggcgatt ttactcatca cgatttcaga aaccctgccc
    51421 caagttctac aaatctttct gggagttttg gcggattttc aacatcatcg tgtcttgaaa
    51481 tacacagtca ttagttttgc aaaatttttg ctttactcta tagtgtcttt atcactttca
    51541 gggcagtcct tttccttgtt attagtagca tttatttgtc tgattaacct cttgtctgac
    51601 acgttgagtt atttttcagg cgccatgctc actccgattt tcattagaat tattgggcaa
    51661 gaccatctgg cagaagctat tggatttaaa cagtcaactg ttagtttagt gaaaacaatc
    51721 agtaatattc taggaggagt cttattaggt attctatcca tccagtttat ttccttgctg
    51781 aacgctctta cctttttaat cgcattttta ggtatcctct tcataaaaac tgacctcttg
    51841 aaagtagaaa aaacgattaa ctatcaagaa ggactctctg taaaatcctt ttgccagcat
    51901 ttgctccaat catcgaaatt gatatggaat atgaataagg tgctcttggt tttgtttatt
    51961 atctctacta gtcaagcagt gataaatgtt acagttcctg tctctactct atttttgagg
    52021 aatcaaccct ttttgaattt acaaacaggt caatctcttg ccttgctatc cacttttgaa
    52081 ctgtcagccc tgattgtcgg aagccttgta agtggctatc tgcaacatac catttccata
    52141 aaaacagctc tctatgcctc acttgtcatc cagttgcttc ttctagtagg atttgccaca
    52201 gttcgttttg actggattct catctttagt accttggatg cctttttcgc aggtgttctc
    52261 tctcctagat tgcaagaact cgtctttaaa caaatacctg aggagtcaat gggagcagtt
    52321 caatcttcta tcagtgccat tacggttgtt ttacctagct tatttacaat atctttggta
    52381 accattgcta ctagctttgg aactctggca gttagctttg ttttattgct atttcttcta
    52441 gttgcctttg ttatgcttct gaatattcgt gaaagtattt agtggagaat ttctataata
    52501 tatgtttgag actggattgc cagtcttttt atgatggtca aaatcaacag acttttttct
    52561 cttttctgaa tgtgttatag tagactgaat ctaaaatagt acgaaacaat tgctaaaaca
    52621 tttatagaaa ttaattttac tttcccaatc gatttgttca tatcttattt caatccatta
    52681 tattaagaca atatgaggag aaagatgaaa gaaaaaggat tttaggaggg ggtgcaggca
    52741 gtcatgccaa cggctcttgg ttatgtcagt atcggcctgg cctgtggaat tatcggtgcg
    52801 ccctatgtga cacctgttga gatgggcttg atgagtctct ttgtttatgc tgggagtgcc
    52861 cagtttgcca tgttggcact gattgtggtt caagctcctg tggcagctat tgctatgacg
    52921 gtttttctaa tcaacttgcg tctctttttg ttgagtttac acgcatcgac ttatttccgt
    52981 cataccagtc tttggtacaa tatcggtatg tctagtatct tgacagatga gacctatggc
    53041 gttttgatgg gtgaattggc ccatacagac aaggtaaatc ctatgtggat gcacggaaac
    53101 aatcttaaca gctatgtggc ttggtttgtg gggacagtag tcggaacggc tctgggtggc
    53161 ctgctaccaa atccagaaat ctttggcttg gattttgccc tggttgggat gtttattggt
    53221 atttttgctt cgcaatttca gattatgcaa agacggattc ctgtccgcaa tctgctcatt
    53281 atcctagcag ttgttgcggt gtccttcttt ttgctcttga cagtggtgtc tcagtcacta
    53341 gctgttctgt ttgcgacgct acttggttgt agcatggggg tggttttaga tggtcagtaa
    53401 gtatctttta ttagcagtta ttttctctgg cttggtgact tggattctcc gtatgattcc
    53461 cttcatctta gtcaagtata agggcttgcc tgcaatcgtt gagcgttttt tgaagttctt
    53521 gcccgtttcc attatctttg ccttgattct ttcaagcgta gtgacaggta aggttgggag
    53581 ccttcctcaa attaaatggc tagacttctt agccgtcttt ccaacagctt gggtagcctt
    53641 tcgctaccgc aatctagtcg gtacggttct ctttggagtg gtcttgattg ccatcttgcg
    53701 tttggtcttt taaattaccc ataaaaaaaa cttatcacag agatagatat catataatgg
    53761 cgtaaatgct ctttttctgt taagattata aggtattcta ttttggagga aatgacatga
    53821 aaaaaatcgt taaatactca tctcttgctg ccctaggact tgttgctgca ggtttgcttg
    53881 cggcttgctc agggggtgct aagaaagaag gagaagcagc tagcaagaaa gaaatcatcg
    53941 ttgcaaccaa tggatcacca aggccattta tctatgaaga aaatggcgaa ttgactggtt
    54001 acgagattga agtcgttcgc gctatcttta aagattctga caaatatgat gtcaagtttg
    54061 aaaagacaga atggtcaggt gtctttgctg gtcttgacgc tgaccgttac aatatggctg
    54121 tcaacaatct tagctacact aaagaacgtg cggagaaata cctctatgcc gcaccaattg
    54181 cccaaaatcc taatgtcctt gtcgtgaaga aagatgactc tagtatcaag tctctcgatg
    54241 atatcggtgg aaaatcgacg gaagtcgttc aagccactac atcagctaag cagttagaag
    54301 catacaatgc tgaacacacg gacaacccaa ctatccttaa ctatactaag gcagacttcc
    54361 aacaaatcat ggtacgtttg agcgatggac aatttgacta caagattttt gataaaatcg
    54421 gtgttgaaac agtgatcaag aaccaaggtt tggacaactt gaaagttatc gaacttccaa
    54481 gcgaccaaca accgtacgtt tacccacttc ttgctcaagg tcaagatgag ttgaaatcat
    54541 ttgtagacaa acgcattaaa gaactctaca aagacggaac gcttgaaaaa ttgtctaaac
    54601 aattcttcgg agacacttac ctaccggcag aagctgatat taaataattt cttgaaatca
    54661 tccattctga gtaagatggg tggtttctca gtttttaggg atatagtttt aaactatata
    54721 tctgactatc taataacaat ttgtgaaatc aaacaaattg tgagatacta gtacggtatt
    54781 atttttaagg agaaagaatc atgaaaatca aaaaatggct tggcctagca gcccttgcta
    54841 cagtcgcagg tttggctctt gcagcttgcg gaaactcaga aaagaaagca gacaatgcaa
    54901 caactatcaa aatcgcaact gttaaccgta gcggttctga agaaaaacgt tgggacaaaa
    54961 tccaagaatt ggttaaaaaa gacggaatta ccttggaatt tacagagttc acagactact
    55021 cacaaccaaa caaagcaact gctgatggcg aagtagattt gaacgctttc caacactata
    55081 acttcttgaa caactggaac aaagaaaacg gaaaagacct tgtagcgatt ggagatactt
    55141 acatctctcc aatccgcctt tactcaggtt tgaatggaag tgccaacaag tacactaaag
    55201 tagaagacat cccagcaaac ggagaaatcg ctgtaccgaa tgacgctaca aacgaaagcc
    55261 gtgcgcttta cttgcttcaa tcagctggct tgattaaatt ggatgtttct ggaactgctc
    55321 ttgcaacagt tgccaacatc aaagaaaatc caaagaactt gaaaatcact gaattggacg
    55381 ctagccaaac agctcgttca ttgtcatcag ttgacgctgc cgttgtaaac aataccttcg
    55441 ttacagaagc aaaattggac tacaagaaag cacttttcaa agaacaagct gatgaaaact
    55501 caaaacaatg gtacaacatc attgttgcga aaaaagattg ggaaacatca cctaaggctg
    55561 atgctatcaa gaaagtaatc gcagcttacc acacagatga cgtgaaaaaa gttatcgaag
    55621 aaacatcaga cggtttggat caaccagttt ggtaataaga aacagggagg tgggagagag
    55681 aattccacct cttgcttttg tatagagcac ggagtgtaaa gaagattatt cgttcataga
    55741 aaggtagaga gaatatggtt tttcctagcg aacaagaaca gattgaaaaa tttgaaaagg
    55801 atcatgtagc ccagcattat tttgaggttt tgcgtacctt gatttctaag aaatcagtct
    55861 ttgcccagca ggttggactc aaggaagtcg caaactatct gggtgagatt ttcaagcgtg
    55921 ttggagctga agtggagatt gatgagagct atacagcgcc ctttgtcatg gcacatttca
    55981 agagttcgcg tccagatgcc aagaccttga ttttctataa ccactatgac actgtgccag
    56041 cggatgggga tcaggtctgg acagaggatc cttttacgct ttcggtccgc aatggcttca
    56101 tgtatgggcg tggggttgat gacgacaagg gtcatatcac agctcgcttg agtgctttga
    56161 gaaaatatat gcagcaccat gatgatttac ctgtcaatat cagctttatc atggagggag
    56221 cggaggaatc ggcttcaaca gacctagata agtatttgga aaagcatgca gacaaactcc
    56281 gtggggcgga tttgttggtc tgggaacaag ggaccaaaaa tgccttggaa cagctggaaa
    56341 tttctggtgg caataagggg attgtgacct ttgatgccaa ggtaaaaagc gctgatgtgg
    56401 atatccactc gagttatggt ggtgttgtgg aatcagctcc ttggtatctc ctccaagcct
    56461 tacagtctct tcgtgctgcg gatggccgta tcttggttga aggcttgtac gaagaagtac
    56521 aagagcccaa tgaacgagaa atggccttgc tagaaactta tggtcaacga aacccagagg
    56581 aagttattcg gatttatgga ttggagttgc ctctcttaca ggaggagcgg atggcctttc
    56641 taaaacgttt ctttttcgat ccagcgctta atatcgaagg aatccagtct ggttatcaag
    56701 gtcagggtgt taagactatt ttacctgcag aagccagtgc caagctagag gttcgtctgg
    56761 ttccgggcct agaaccgcat gatgttctgg aaaaaattcg gaaacagcta gacaaaaatg
    56821 gctttgataa ggtagaatta tactatacct tgggagagat gagctatcga agcgatatga
    56881 gcgcaccagc cattctcaat gtgatcgagt tggccaagaa attctatcca cagggcgttt
    56941 cagtcttgcc gacgacagcg gggacaggac ctatgcatac ggtctttgat gccctagagg
    57001 taccaatggt tgcattcggt ctaggaaatg ccaatagccg agaccacggt ggagatgaaa
    57061 atgtgcgaat cgctgattat tacacccata tcgaattagt agaggagctg attagaagct
    57121 atgagtagag atattatcaa gttagatcag atcgatgtga cttttcacca aaagaagaga
    57181 accatcacag cggttaagga tgtgaccatt cacatccaag aaggggatat ctacggaatc
    57241 gttggatatt ctggagcagg aaaatcaacc cttgtacggg tgattaatct cttgcaaaaa
    57301 ccatctgcag ggaaaattac cattgacgac gatgtgattt ttgacggcaa ggtgaccttg
    57361 acggcagagc agttgcgtcg taaacgtcaa gatatcggaa tgattttcca gcattttaac
    57421 ctgatgagcc aaaagacagc agaggagaat gtagcctttg cccttaaaca ctctgaactc
    57481 agcaaggaag aaaagaaggc taaagtagct aagttgttgg acttggttgg tttggcagat
    57541 cgtgctgaaa actacccttc acaactatct ggagggcaaa aacagcgtgt ggcaattgcg
    57601 cgtgccttgg ccaatgatcc aaaaatcttg atttcagacg agtcaacttc tgcccttgat
    57661 ccgaagacaa ccaagcagat tttggccttg ttgcaagatt tgaaccaaaa attaggcttg
    57721 actgttgtct tgattacgca tgaaatgcag attgtcaaag acattgccaa ccgtgtggcg
    57781 gttatgcagg atgggcattt gattgaagag ggtagtgtgc ttgaaatctt ctcagaccct
    57841 aaacaacctt tgactcaaga ctttatctca acagctacag gtattgacga agccatggtc
    57901 aaaatcgaga agcaagaaat cgtggaacac ttgtctgaaa acagtctctt ggtgcaactc
    57961 aagtacgctg gatcttcaac agacgagcca cttttgaatg aattgtacaa gcattatcaa
    58021 gtaacggcta atattctcta tgggaatatc gaaatcctcg atggtactcc tgttggagaa
    58081 ttggtggtgg tcttgtcagg tgaaaaagca gcgttggcag gtgcccaaga agccattcgt
    58141 caagcaggtg tacaactaaa ggtattgaag ggaggacagt aagatggaat cattgattca
    58201 aacctattta ccaaatgtct ataaaatggg ttgggctggt caggcaggct ggggaacggc
    58261 tatctactta actctttata tgacagttct ttccttcatt atcggaggct tcttggggct
    58321 agtggcaggt ctctttctcg tcttgacagc gccaggtggt gtcttggaga ataaagtcgt
    58381 attctggatt ttagacaaaa ttacctcaat ttttcgtgcg gttcccttta tcatcctctt
    58441 ggcaatcttg tcaccacttt ctcacttgat tgttaaaaca agtatcgggc caaatgcagc
    58501 ccttgtccca ctttcttttg cagtctttgc cttctttgcc cgtcaggtgc aggttgtctt
    58561 ggctgaattg gatggcggtg tcattgaggc ggctcaagcg agcggagcga ctttctggga
    58621 catcgtgggt gtttacctat cagaaggtct tccagatttg atccgtgtga cgactgtgac
    58681 cttgatttcc cttgttgggg aaacagctat ggccggtgcg gttggagctg gtggtatcgg
    58741 taacgtagcc atcgcttatg gatttaaccg ctacaatcac gatgtgacca tcttggcaac
    58801 cattattatc attttgatta tctttgcaat ccaattcttg ggagatttct tgactaagaa
    58861 attgagccat aaataaaaaa gagccgcgtg gctcttttta actgatcaga ttttctgtgc
    58921 aaatttttta ctcaaggctt gtccaatcaa ggcacccact agggctccga tgacaatact
    58981 tgcgataaat agaaggacag ttccagggtt tggagcgacc atgatacggt cgatatattc
    59041 ttgggatttt cctcttgcca gaagagtagc catataggct ttgggcgcaa tccacataag
    59101 caagattggt cctgttgtac taaaggcgaa aataatgaaa gaaaggaagt tctttgtttt
    59161 gtccttgtat tttcctaaat gagctactcc atctgctagg aggccacaga taattccagg
    59221 aaggaaggaa ccagcaccgt gtttagttcc caagaaaaag agggcaatga caaggccgat
    59281 agtggtaatg gctccaaagc gcggaacttt tgcgactagg atcatataga cgctaccgcc
    59341 gacaagggca gtaaaggcag gcgcataaaa catgtttccc gtttggtcaa agagattgcc
    59401 caaaaggaca ccaatcccca tgcagaggaa gtaaagaact gcaaaaagca gtgtagttaa
    59461 gatagatttc ttcatgaatt gtctcctgat aattttttca caattctcat tttaccatgg
    59521 tttggtggga ttgtaaatgg atactagaag tttttgaaaa cgcttgaaat atgatataat
    59581 ggtttcatag ttatttttag gggaatatca tgggtagatt tttagacttt gtctttaatc
    59641 gtttcttttt agggatgatt gcgacagcct tcttttggct attaacttta gcaggaggga
    59701 ttatccttgg tctagcgccg gctagtgcca ccttgatgag cttatatgca gaacatggtt
    59761 atagctttcg ggaatacagt ttgaaggagg cttggtctct ttacaagcaa aattttatct
    59821 caagcaacct gattttctat agctttttag gtgtgggtct agttttgacc tatggtttgt
    59881 atctcttggt gcaattgcct catcagacca ttgttcattt gattgcgacc cttttgaatg
    59941 tcctagtagt tgccctgatc tttttggctt atacagtatc tttaaaatta caagtttatt
    60001 ttgccttgtc ctatcgaaat agtctcaaat tatccttgat tggcatcttt atgagtctag
    60061 cagctgtggc caaggttctc cttgggactg tgctacttgt agcaattggt tactatatgc
    60121 ctgccctgct attttttgta ggaattggga tgtggcattt ctttatcagt gatatgttgg
    60181 aacctgtcta tgaaatcatc catgaaaaat tggcgacaaa atagaatgaa gcacttttgg
    60241 ctacatacgc ttctaagaac ctatagttca gtgatgatca ttatcattgc gagttttgca
    60301 atcttactct cttacgctga ctgggattca cgtgaaaagg aagcccagag agtagcccag
    60361 cgtgtaactg ctagaacagt gagtgaaatt gaatattacc atagagagtc aacccagata
    60421 gctcaggctt tagttgaaaa tcaagctcgt attgagggaa tctataaata ctttagcctt
    60481 agcatgccag actattttta ctggcaatta gagcggaaag cttcgcctta tatatcagtc
    60541 tctctgtatg aaaatgttga tgacctctat gttcgaaatg attttgtaac tggagtggcc
    60601 attgcttttc aagattacaa ggaagtctat gtttctacta aagacaaacg tagtggagaa
    60661 aaaatcaggg ctgaggattt caaaccagca ggaaatagtt ttgccattcc ggtgtcagat
    60721 ccagtgtcag atcaagattt aggagtgatt tacatctcct tggatcctgc tgttttatac
    60781 catgccattg ataatactag aggtcatact ccgatggcag taacagtgac ctcacctttt
    60841 gatacggaga tttttcatat tggtgagaca gttgataagg agagtgaaaa ttggctagtt
    60901 ggcttaactt ctcatggata tcaggttcag gtggcagttc ctaaaaactt tgttttacaa
    60961 ggaacagtga ctagctctgc tttgattgtg ggtttgagcc ttctctttat tgtcattctt
    61021 tatctgactt tgaggcagac ttttgctaat taccaaaagc aggtagtgga tttagtagaa
    61081 tccattcaag tcattgctca aggcgaagag gggcgtcgga ttgacatttc cgagaaagat
    61141 caggaattac tcctaatcgc ggagacgacc aatgatatgt tggatcgatt ggaaaagaat
    61201 atccatgata tttaccagtt agagcttagt caaaaagatg ccaatatgcg agccttgcag
    61261 gcgcaaatca atcctcattt tatgtataat acgctggagt tcttgcgcat gtatgcagtt
    61321 atgcagagtc aagatgagtt ggcagatatc atttatgaat tcagtagtct cttgcgtaac
    61381 aatatttccg acgaaagaga gaccctcctc aaacaggaat tagaattttg ccgtaaatac
    61441 agctatctct gcatggttcg ctatcccaag tccattgcct atggtttcaa gatagatcca
    61501 gagttagaga atatgaagat tcccaagttt accttgcaac cgctggtaga aaactatttc
    61561 gcgcatggtg ttgaccacag gcggacagat aatgtgatta gcatcaaggc tcttaaacag
    61621 gatggttttg tggaaatttt ggtggtcgat aatggtagag gaatgtcggc tgaaaagttg
    61681 gcaaatatcc gagaaaaatt aagtcagaga tattttgaac accaagccag ctacagtgat
    61741 caaaggcagt ctatcgggat tgtcaatgta cacgagcgtt ttgtgctcta ttttggagac
    61801 cgctatgcca ttacgataga gtctgcagag caagccggtg ttcagtatcg tattacaatt
    61861 caagatgagt agaaagggag aaaatgtata aagtattatt agtagatgat gagtacatgg
    61921 tgacagaagg tctgaagcgt ttgattccct ttgataagtg ggatatggag gtcgtcgcaa
    61981 cagccggtca tgccgatgaa gctctagaat atgttcagga aaatcctgtc gatgtcatca
    62041 tttccgatgt caatatgcca gacaaaacag ggcttgatat gattcgggag atgaaagaga
    62101 tcttaccaga tgctgcctat atcctgctct caggttatca ggagtttgat tatgtaaaaa
    62161 gagcaatgaa ccttagtgtg gtggactatt tggtcaagcc tgttgataag gtagagctgg
    62221 gaaatctgct ggagaagatt gcaggtcagc tcggcgagag agggaagaaa agtcagactc
    62281 ttagtcaaga attagacgag gctggatttg ttagttattt aggggataag gagaattggt
    62341 ggataggtct atccaaggaa aaacaaggtt ccttcaccat tccctactat gtcttgggtc
    62401 aagactggca gattttcatt tctggccaac ccctagatgg tttagtcgtt acaccttttg
    62461 aagctcctta tcaagaacac tttgaacgct ggaagctgaa tgctgagaaa accctctttt
    62521 acggttctgt aaatttgcag cagtctgaga gtctctttgc ctattacgaa ccgatttata
    62581 gggttatcat tcagggaaat ctcaatcaaa tcgtagaaga gttaaatctc ttggagaagg
    62641 tagttcttga aaatacgccg cgtgttccga ttactaaaca gctttttatt cagtttgtca
    62701 tggatgtttt ccatttattt gaacatctca aagctgatga cctgacagac atcgtcaaaa
    62761 ccattcatgc tattcaatcc ttcgatgaat tggttcctta tatcaaggaa actctgacca
    62821 gctttttcgg tcaataccgt atgaatgaaa atgtggccag tgtgctggaa gtcattggtc
    62881 gtgattacca aaaagagctt tccctcaagg atatcagtaa ggccctcttt atcaatcctg
    62941 tctatctagg gcagttgatt aagcgtgaaa ccgattcgac ctttgcagag ttactaaaca
    63001 aacaacgtat taaggctgcc caacaacttt tgctttcaac tagtgacagc atcgaagata
    63061 tttgttatgc tgttggttac agtaaccttg gatatttcta taaagttttc cgaaaattgt
    63121 gcggaaaatc gccaaaagcc taccgaaaac aggtagaaac tatactataa gatttgtatt
    63181 cctttacaaa aggtgctata atattatcag gaggtcctat catgaaaaag aaaccaattt
    63241 atctatgggt cttgctaatc ttgtctgccc ttatttcagt tccgtctctg tttggaattg
    63301 tgagtccctt gcctagtaaa gaagcccttc gtgctgctca gaaacaagtt gcaggggtca
    63361 atgctcagca attagaagac cagcttaatt atacctatag agtagcagaa gcatctcatt
    63421 ctatttttaa tgttgctttg attgtgctat ctactatttt agtggtcgta gcgattgtct
    63481 tccttgttcg taaaaatttg caatatgcaa actatactta cgttggctat gttttgttag
    63541 ctattattgg ttcgatttat ggctatgttg gtttacaaga cgctgtgcag ttggttcaag
    63601 atgagagcat gcgtttgaca gtgagtattg gctcaaaagc tgttagcatt ttctatatcg
    63661 tcatcaatgt tctcttccta gcccttgtct tctataagat gtggcgacaa cagaaagcct
    63721 tggcagaaga agaggaaaca gaagagcttg cctaagtatt gacaaaaaag aactatcaag
    63781 atacaatctt ggtagttgtt ttttgattat agataaaatc atggaggtac atatgaagac
    63841 aatttcttta gtttatatta gtttgagtgg caacactgaa agttttgtga cgcgcttgaa
    63901 agactatctc ttgtcccagt acaaagggat tgaggttcaa aagattcata tcaaggattt
    63961 ggtcaaggaa ggcaaaaatt tctatgaaat ggaccatccc tatgtcgctt ttttgccgac
    64021 ctatctcgaa ggtgggaatg gcgtggataa cggagatgtt gagattttga cgacaccggt
    64081 gggagatttt attgcctatg gtaacaatgc tagtaagtgt tttggtgtgg ttgggtcagg
    64141 aaatcgtaac tttaataacc aatactgcct aacagccaag caatacagtc aacgctttgg
    64201 cttccctgta ttggctgact ttgaaatgcg aggcatgctg gaagatatca aacatgtcgc
    64261 agctattatc gcagatttgt atgagttgga aaaggagaat taatactcaa tgaaaatcaa
    64321 agagcaaact aggaagctag tcgcaggttg ctcaaagcac agctttgagg ttgcagatag
    64381 agctgacgtg gtttgaagag attctcgaat agtataaagt tcttataaga ggtggttgaa
    64441 gttgttcaac tgttttttga gtataaacag tctttaagaa cgtaaaaaag cataagttca
    64501 ggtcttcaaa accttgttct tatgcttttt atcatagaaa tatttgctga attttctctt
    64561 gaaatgaaac cttatcttca tctcgcgctt gtcccttacc ctgcttttcc gattgcgagt
    64621 gcgtagataa agaagatggc gaagccaaag aggaaaatca atcccgcaat ggcaaggtgt
    64681 ttgagccaag aaggaagatt tttgttttca cgcgttacca aggcgtaatt caaaagagca
    64741 aagaaaggtg ttgtcaggaa agatccaatc atggcaaagc ggagcatggt tgaaacctga
    64801 ccagcgaaga acttgataat gacgataccg atgatagcag tgatggtcat ccagatgttc
    64861 aaagatttac gattgtcctc tttttgactg attagcagtc ggagagattc ctgattaacg
    64921 cgagaatagc catcgataac agttataact gttccaaaga tacagaggaa ggcaataaag
    64981 gtaatcaagt aacgggacca ttcgccaaga acagaggcat acatgcccac gaattgagag
    65041 atgtatttgg ctgaagcagc ttcaaccgcc tgccctgtag gatattgaat cagtgctccc
    65101 agtgccacaa agaagacggc taggatagct gttccaatat aaccagtgtt aaagtcaaac
    65161 agagcgtctt ctgtgttaaa gttgacggtc tttctctttt cagctgacca aagtgaattg
    65221 atggctgaaa tttcaatagg agccggcatc catcctagga gggagacgat gaagggcaga
    65281 gctgccattt gccaaggtgt cttctcgaca aaatcagaac tgtattctgg atgcttgacc
    65341 gccgcaatga taactgccag aacagtcgca atggttaagg cagacataat ccatttgacc
    65401 atgccgtcta aaagtttgta gcctccaaag agtagcatag cccaaatgat tgcaacgaga
    65461 atgagggacc actgagtaat gctaagtcca atcattggga aggcactggc gatgatagct
    65521 gagcacagaa tggcaacacc agccgtgttg accatagccg aaaagacatt gaggataaag
    65581 aaaatccaga gatagagttt tcctttttcg gcataacctt caaccaaagt ctttccagta
    65641 tcagctgtgt attcagcacc aaaacggaaa aatggatatt taaagacatt ggctaagatg
    65701 accaagagaa gtagagacca accgtaagaa ccgccagctt gagttgagga tacaatgtgg
    65761 gaacctccaa cagcggcagt tgccattagg attccaggtc ccattgcttt tagcttgctt
    65821 gcccaggttg attgatttaa ggaaatagct tgcgacatga taaatactcc tttttgaatt
    65881 ttcagaataa tctgtatatg taatctatat tctacaaaaa attttggaaa aatgcaagag
    65941 tattttgaaa aaagatagaa aatttacaaa gaagatctga aataactgtt atgatatagc
    66001 ggattgaaac tagaatagta cacctttgct tctaaaacat tgttagaaat cgatttgact
    66061 gtcctgatcg atttatcctg ttcttatttc atttcactat agtaaggtgc agcaggataa
    66121 agaaaaaccg agaagtttct ttctcggatt tgcttattat gaggtgccta ttttctatgc
    66181 tccaagagtt gattgatgtg atctactttt ttagcctctc ttttatagag aatagcccag
    66241 atgatgagat agacaatcgc aaactcgata atgagctgga ggtagaaaat ccagtggaag
    66301 gggaaccaac cagcaagagt tgctagtggg acaaagccag ccagcataag gaagaaatga
    66361 gtcagagtgg cacgaagcat gctccagtca cggctgaata agcggttgcc aaagttgaag
    66421 agcataccga tggctgccca gataagtgtg cagtagagca agaccagggc accgtgaacc
    66481 tgatgctgat ccatcacttg gccgatgaga gagtagggat ttagtggtgc gtaggtattt
    66541 ggtgcataaa tgagtgaaaa gaggatggag aggatgaggc cgataagaac accggcagct
    66601 gcatcgtgaa atacttgttt tttcatagtt ctaatttctc cttgatggtt tttagataac
    66661 ggcgtgaaga gtaggtgaag ctttcgtttt tcaagaaaat ttctaccaga ccgtttggcg
    66721 tgagcttgag gtgagagatg gaatcgatat tgatgatttc tgattgggaa atttggataa
    66781 aattgcttgg caagagttta agaacctgat agagtcgcaa atcaatgctg taggtctgac
    66841 tcgcggtttc tgctagaacc ttccgattct cgatatagaa gcgctgaatc ttgccaatct
    66901 caactagata gacctgatca tcgatttttc ctttgatttt ttctctttgg tccagatttt
    66961 ctgcgaactc gatgactttc tggacttttt cggtttcttg aggtgcttgg acaatcagct
    67021 tttcctcctc gtaagtctca ctaatctgta gttctacttt cataaatttc tctccttgtt
    67081 tttcatacaa aattaatctc acttcttgta cacctttatt aatactcttc aaaaatctct
    67141 tcaaaccacg tcagcgtcgt cttgccgtag gatagttgtt gactttgtca gttttatcta
    67201 caacctcaaa acagtgtttt gagctgtctg cgcctagctt tctagtttgc tctttgattt
    67261 ttattgagta taccactatt ttactccctc tggcaaggga ctttgtctat gtggagggat
    67321 tgggctccta tgtggtggag cttttctgtt ctttctgaaa tatggtataa tagcactaat
    67381 taatttctag gaaaatagat acagaaaggg gctgaaagat gtctcatatt attgaattgc
    67441 cagagatgct ggcaaaccaa atcgcagctg gagaggtcat tgaacgtcct gccagtgtgg
    67501 tcaaagagtt ggtagaaaat gccattgacg cgggctctag tcagattatc attgagattg
    67561 aggaagctgg tctcaagaaa atccaaatca cagataacgg tcatggaatt gcccacgatg
    67621 aggtggagtt ggccctgcgt cgccatgcga ccagtaagat aaaaaatcaa gcagatctct
    67681 ttcggattcg gacgcttggt tttcgtggtg aagccctgcc ttctattgcg tctgttagtg
    67741 tcttgactct gttaacggcg gtggatggtg ctagtcatgg aaccaagtta gtcgcgcgtg
    67801 ggggtgaagt tgaggaagtc atcccagcga ctagtcctgt gggaaccaag gtttgtgtgg
    67861 aggatctctt tttcaacacg cctgcccgtc tcaagtatat gaagagccag caagcggagt
    67921 tgtctcatat cattgatatt gtcaaccgtc tgggcttggc ccatcctgag atttctttta
    67981 gcttgattag tgatggcaag gaaatgacgc ggacagcagg gactggtcaa ctgcgccaag
    68041 caatcgcagg gatttacggt ttggtcagtg ccaagaagat gattgaaatt gagaactctg
    68101 acctagattt cgaaatttca ggttttgtgt ccttgcctga gttgactcgg gctaaccgca
    68161 attatatcag tctcttcatc aatggccgtt atatcaagaa cttcctgctc aatcgtgcta
    68221 ttttggatgg ttttggaagc aagcttatgg ttggacgttt tccactggct gtcattcaca
    68281 tccatatcga cccttatcta gcggatgtca atgtacatcc aaccaagcaa gaggtgcgga
    68341 tttccaagga aaaagaactg atggcgctgg tctcagaagc tattgcaaat agtctcaagg
    68401 aacaaacctt gattccagat gccttggaaa atcttgccaa atcgaccgtg cgcaatcgtg
    68461 agaaggtgga gcaaactatt ctcccactca aagaaaatac gttctactat gagaaaactg
    68521 agccgtcaag acctagtcaa actgaagtag ctgattatca ggtagaattg actgatgaag
    68581 ggcaggattt gaccctgttt gccaaggaaa ccttggatcg attgaccaag ccagcaaaac
    68641 tgcattttgc agagagaaag cctgctaact acgaccagct agaccatcca gagttagatc
    68701 ttgctagcat cgataaggct tatgacaaac tggagcgaga agaagcatcc agcttcccag
    68761 agttggagtt tttcggacaa atgcacggga cttatctctt tgcccaaggg cgagatggac
    68821 tttacatcat agatcagcac gctgctcagg aacgggtcaa gtacgaggag taccgtgaaa
    68881 gcattggcaa tgttgaccag agccagcagc aactcctagt gccctatatc tttgaatttc
    68941 ctgcggatga tgccctgcgt ctcaaggaaa gaatgcctct cttagaggaa gtgggcgtct
    69001 ttctagcaga gtacggagaa aatcaattta ttctacgtga acatcctatt tggatggcag
    69061 aagaagagat tgaatcaggc atctatgaga tgtgcgacat gctccttttg accaaggaag
    69121 tttctatcaa gaaataccga gcagagctgg ctatcatgat gtcttgcaag cgatctatca
    69181 aggccaatca tcgtattgat gatcattcag ctagacaact cctctatcag ctttctcaat
    69241 gtgacaatcc ctataactgt cctcacggac gtcctgtttt ggtgcatttt accaagtcgg
    69301 atatggaaaa gatgttccga cgtattcagg aaaatcacac cagtctccgt gagttgggga
    69361 aatattaaaa gtataaaaaa gtctgggaaa aattttcaaa atcagaaaaa cgcataaaat
    69421 caggtgttca aaaaccttga ttttatgcgt tttatcatag aaatatttac ttcatgtttt
    69481 cctaattctt ttcgaaactc tttttaaacc acgtcagttt tatcagtaat ctcaaaacag
    69541 tgttttgagc taattttgcc agttttgtct gtaacatcga agttgtgttt taccactctg
    69601 cgactggttt cctagtttgc tctatgattt tcacagagta ttaaattgcg attttgccaa
    69661 gtttctttat tcgtctaaaa gtagagtctg ttctatgcgt ctaatgtacg aattaggttg
    69721 accatttcaa tagctccttg tgcacactca gaacccttat ttcctgcttt ggtaccagct
    69781 cgttctatgg cttgttcaat tgtatctgtc gttagcacac caaacataac aggaatttcg
    69841 ctatttaaac tgatttgggc gattccctta gatacctcgc tacatacata atcataatga
    69901 cttgtattcc ctctaatgac agctcccaag cagataattg catcatattt tttacttttt
    69961 gccatttttg atgcaatcag tggtatttca aaagctcctg gaacccaggc tacctctata
    70021 tctttctcgt ttacattctc tcttttgaga ttatctagtg ctccagataa taattttgaa
    70081 gttataaatt cattaaatct cgctacaaca atacctattt taatattgtt tgctactaaa
    70141 ttaccttcat aagtgttcat ttatttttcc tccatattta aaatgtgacc cattcgattt
    70201 ttctttgttt ctaaataaaa actatcgtaa ggattggctt ctatttcgat tgatattcta
    70261 ctggaaatgg taattccata tttttctaac tgttcaacct tgtcaggatt atttgtcagt
    70321 aaatgaagtg actgaagtcc cagatcttta agcatttgtg ctccaatatg atattctctt
    70381 aaatcacctt caaagcctaa tgcaagattg gcatcaagcg tatccatgcc ttgatcttgt
    70441 aaatgatagg cttttaattt attgataagt ccaattcctc gtccctcctg tcgcaagtaa
    70501 agtaagacac ccgaaccatt ctcaacaatc attttcatag ctttatcgaa ttgctgtcca
    70561 caatcgcaac gtaaagagcc taaaacatct cctgttaaac attcggagtg gacccgacat
    70621 aatacattgg cttcatcctc tatgtttccc ataataagag caagatgatg ttccccattt
    70681 agtttatcta tatagctaat tgctttgaaa ttaccgtatc tagtaggcat attgacagtt
    70741 gaaactcgtt ctaccagctg atcatatact tttctatatt cttgtaattc tttgatggta
    70801 attagtggaa tgttgtgttt cttcgagaac tgaattaaat catctgttct catcattttg
    70861 ccatcatgat tcattatttc acaacatagg ccacactctt ttagtccagc taattttaat
    70921 aaatcaacag ttgcttctgt gtgtccattt ctttctagaa caccaccttt ttttgcaatt
    70981 aaaggaaaca tgtgtcctgg cctgcgaaaa tcagagggtg ttatatcttc agctacacac
    71041 atacgtgcgg tcagtcctct ttcctcggca gaaatacctg tggtcgtttc tttataatca
    71101 attgaaactg taaaagcagt cttatgatta tctgtattgt tttcaaccat aggtgaaagc
    71161 attaattgat tagctaaact ttcgctcata ggcatacaaa ttaatccttt ggcataagta
    71221 gccataaaat taacattttc tgttgtagct gcttgtgcag aacaaattaa gtctccttca
    71281 ttttctctat ccttgtcgtc tataacaaga acaagtcgtc ccttctgcaa tgcttctaat
    71341 gcttcttgta tttttcgata ttccattgac tgattatcct ttctgctaaa atccattttg
    71401 atataatagt tccttagata tttctgattt tggagagtta tccatcagtt tttgcacata
    71461 tttacctaag atatcatttt caagatttac tgtactcccg acttgtttac tcttaagaat
    71521 ggtttgttcc aaggtatgag ggataacaga tactgaaaag tttactttgg agactttagc
    71581 gacagtcaga ctaatgccgt caattgtaat agatcctttt tcaactatta aatctaaaat
    71641 ttctttttgt gtgttgattt gataccatac agcattatca tcttttttta ttgacgagat
    71701 ttttcctgta ccatcaatgt gtcctgtaac gacgtgaccc ccaagtcgac cgttgacaga
    71761 taaggctctt tctagattca cctcacttcc atgttttaat agagtaagag ctgttcgact
    71821 ccatgtttca ttcattacat caactgtaaa ggattgatga ttgaaatgag taactgtaag
    71881 acagatacca tttactgcta tactatcgcc taaatggata tccgttaata tttttgaggc
    71941 tttaattgat agtttacaat tacgagagtc tttctgtatt ctttcaactt ttccgatttc
    72001 ttcaattatt cctgtgaaca tggataaatc acttcacttt ctatgagata gtcatttcct
    72061 atttgagaaa aagcataagg tttcaatcta atagcgtcat ttggcaaaga aatgccttca
    72121 cctccgacag gaaacttggc actgcctcca aaaatttttg gtgcaatata tattttcagc
    72181 tcatcaacaa tttgttgttc caaagcactc caattcatta gactgccccc ttctagaact
    72241 aggctatcaa tctgcatgtt tcctagatgt tgcattaaac tcgataagtc tatatgattg
    72301 ccttttttct ttatggaaag tatttcacag ccatgatttt gatatagctt cattttattt
    72361 ttgtcttcag aggaagtggc aatgtaagtt ttaatatcat ttgctgtttt tacgatttta
    72421 gaggtaagag gagttcgtaa atgtgtatcg catatgatac gaataggatt tttcccttcc
    72481 tccaatctac atgtcagcaa aggatcgtct tgaataacag tattgactcc caccataatt
    72541 gcactaacat ggtgtcgtaa ctgatgcaca tgctttcttg cttcttcttc agtaatccat
    72601 ttggattgat ttgttttagt ggctattttt ccatccattg acattgcata tttcataaaa
    72661 acatagggta catgctgggt aatatacttt ctaaaacttt ttattaagtt aagacactca
    72721 ttttctaaaa ttccaacagt aacttgaaga ttattttcct caagtatctt tactcctttt
    72781 ccagatacaa taggattaca gtctaggctt ccaatgacta ctcttgtaat accactatcg
    72841 attatagcat ctatacaagg aggtgttttc ccgaagtgac aacagggttc aagtgttaca
    72901 taaagcgtcg ctccgacagg ggattctcta cagtttttaa gagcatttct ctcagcatgt
    72961 gagccaccaa aaaactcatg ataaccttgt ccgatgatgt gattatcttt tacaataact
    73021 gcgccgacca taggattggg attgacgtaa ccagcccctt tttgtgccag ttttattgct
    73081 aatttcatat attttgaatc gctcatctca ctacctccaa aaaaatatac cttgaatagg
    73141 agactactca aggcatacaa aagaaaactt atgcgattaa caaaaatgct ctgaaatgac
    73201 aagtaatcat ttcagagcac gcaaaaagca caaatatact tttatcttct ttcatccaga
    73261 ctatactgtc ggctttggaa tttcaccaaa tcatgccttt cggctcgtgg gctataccac
    73321 cggtagggaa ttgcaccctg ccctgaagat agttattcaa ttacagatga ttatagtact
    73381 taattttgaa tatgtcaaca gataaatacc gattgttttt gatatactgt atttgtgata
    73441 atcgattctc gctcctcgga taaagaaaat atgatatact agataaacga aataagagag
    73501 aaggaacact atgtacgcat atttaaaagg aatcattacc aaaattactg ccaaatacat
    73561 tgttcttgaa accaatggta ttggttatat cctgcatgtg gccaatcctt atgcctattc
    73621 aggtcaggtt aatcaggagg atcagattta tgtgcatcag gttgtgcgtg aggacgccca
    73681 tttgctttat ggatttcgct cagaggatga gaaaaagctc tttcttagtc tgatttcggt
    73741 ctctgggatt ggtcctgtat cagctcttgc tattatcgct gctgatgaca atgctggctt
    73801 ggttcaagcc attgaaacca agaacatcac ctacttgacc aagttcccta aaattggcaa
    73861 gaaaacagcc cagcagatgg tgctggactt ggaaggcaag gtagtagttg caggagatga
    73921 ccttcctgcc aaggtcgcag tgcaagcaag tgctgaaaac caagaattgg aagaagctat
    73981 ggaagccatg ttggctctgg gctacaaggc aacagagctc aagaaaatca agaaattctt
    74041 tgaaggaacg acagatacag ctgagaacta tatcaagtcg gcccttaaaa tgttggtcaa
    74101 ataggagcag agaatgacaa aacgttgttc gtgggtcaag atgaccaacc cgctctacat
    74161 cgcctatcat gatgaggagt ggggtcagcc cctccatgat gaccaagcat tgtttgagtt
    74221 gttgtgtatg gaaacctatc aggcaggcct gtcttgggaa acggtactca acaaacgcca
    74281 agctttccga gaagcctttc atagctatca aattcactca gtcgcagaga tgactgacac
    74341 tgaattggaa gccatgctgg agaatccagc tatcattcga aatagagcca agatttttgc
    74401 tacacgcgct aacgcccaag cctttctaca gttacaggca gagtacggct cttttgatgc
    74461 ctatctttgg tcttttgttg aggggaaaac tgtcgttaac gatgttcctg attatcgcca
    74521 agccccagct aaaacaccct tatctgagaa attagccaaa gatctcaaaa aacgaggctt
    74581 caagttcaca ggcccagtcg ccgtattgtc ttttctacag gctgcagggc tagttgatga
    74641 ccacgagaat gattgtgagt ggagaggtct taaatgatgt ctaacaaaaa taagggaatt
    74701 ctgatttttg cgattctcta tacagtcctc tttgtgtttg atggcgttaa attgctggct
    74761 tctttaatgc catctgccat tgcaaattat cttgtttatg tagttttagc tctatatggc
    74821 tccttcttat tcaaggatag attgatccaa caatggaagg ggattagaaa gactaaaaga
    74881 aaattcttct ttggcgtctt aacaggatgg ctctttctca ttctgatgac tgttgtcttt
    74941 gaatttgtat cagagatgtt gaagcagttt gtgggactag atggacaagg tctaaatcag
    75001 tctaatattc aaagtacctt tcaagaacaa ccactactga tagctgtttt tgcttgtgtc
    75061 attggacctc tggtagaaga attatttttc cgtcaggtct tattgcatta cttgcaggaa
    75121 cggttgtcag gtttactaag cattattctg gtaggacttg tttttgctct gactcatatg
    75181 cacagtttgg ctctatcaga gtggattggt gcagttggtt acttaggtgg aggccttgcc
    75241 ttttctatta tttatgtgaa agaaaaagag aatatctact atcccctact tgttcacatg
    75301 ttaagcaaca gcctctcctt aatcatttta gctatcagta tagtaaaatg aaatgagaac
    75361 aggacaaatc gatttctaac aatgttttag aagtagaggt gtactattct agtttcaata
    75421 tactgtaata tgtgatgaaa atgccagtaa tgataccgag aaaaaagctg agaaactttt
    75481 cccagcttta tttgttatag tcaaagagaa tgacttgttc ctgtgcatct acatgagcat
    75541 ggaccccaaa gggtacaatt gctcttggag ttgcgtggcc gacattcaga ttatagacaa
    75601 tcgggatatt gctgtcaatg atatccaata gtgcctcttt atagtcgtca tggaaagttt
    75661 catccatagg ttttccgacc aagagtccat tgatgaccgc gaatatgcca gtgtccttta
    75721 aagttagcaa catctttttg aagtcttctg gcttaggctt ttcttcgctt gtttcgagca
    75781 agaggatttt cccttcccag tctgacaagt cagggaaaag tttgtatttt tggcagagct
    75841 ccgtgctatc tgcgtatcga gagttgtcaa agatatcgta gagggattcg aggcaaccac
    75901 cgaggatttt cccctcgaac tgggcacttc cttgcaacaa gtcaaaacct gtatttgtat
    75961 gactgacacg aggtgttccc agggccgtgg gactaaaatc agttcgttcc tcataccaaa
    76021 cgtcactagg gcggatttct gaaattcttc ccgtctcaat caattcttta aagtagtgaa
    76081 ggctataggc tagcatttct ttgtctaatt cacaaatgtc tgctaaaaag gattgaccat
    76141 aaaaagtctt gattcctaat ttatgcaaca tgaggtggtt catggttgta tccgagaagc
    76201 caagaaaaat tttttgtttg ataacctttt ggagttggtc attttcaaaa agataaggta
    76261 gcaagcgata ggtatcgtct ccaccgatgg cacataggat catgtcgatg ctatcatcag
    76321 aaaaggcatg aatcaaatcc tctgcacgag cttcaggatg gtccttgata aagtctaatc
    76381 cttttaacga atggggcaaa aagatgggat tgagtctcag atccttgaga cgttggatac
    76441 ccaagtccac ttcgtgtttg acaaaatcct ctccgataat gccactagat aaactaacaa
    76501 taccaatagt agaaaccata tctcatcctc ctagaaatag attgagccta ttttatcaca
    76561 aaatataaga gaaagctatg tgggatttca gaagaatact tttaatactc ttcgaaaatc
    76621 tcttcaaacc acgtcagttt tatttgcaac ctcaaagctg tgctttgagc aacctgcagc
    76681 tagcttccta gtttgctctt tgattttcat tgagtataac tcaaaaaagt aagtgaaaaa
    76741 gcaaccgcac ctgcagttgc ttttatcgtt ttcttattct tgatagcgtg ttggtcctgc
    76801 acttgcacta cggatattca agcgtttctt gagatagaag cgaagggcta ggagggctgc
    76861 tccaataata gctagtggca atggatccag tactgggtta aggctagctg gtaggaagct
    76921 tgttgcaaag aagacaagca accaaaggaa catagaagct aggataacta gtacagattt
    76981 ccagaaaggt ggacgttgac tgcgatccat atttggtcca tagtattggt aaacaaagta
    77041 gtacatcaag tagaaggcaa atccaccaac cagtccaact aatagaagag taatcaatcc
    77101 atagccgaaa gcttgatctg ccgcaaagaa ggttgtgagg gcgctgacaa gggcaaagag
    77161 gctagtgatg aaaagagctg agtccataat catcagtttt ggatcatcat tttcttttgg
    77221 atgctctttt tcgtactgct ctttgacagt gaagctatga gcccaatgag ttggtgcgcc
    77281 gtatagggaa cgggcagttg tacctttaga ttgctcctca aggatttggg gaatgacttc
    77341 ctcaaaaata gtctggattt cagcgtctgt tttcccatct ttgatgaatt gttgggtagc
    77401 aatgtggaca aactcttggt ttttcttagt taatttttgt agatcaattt gagacatagg
    77461 aactcctctt agaaccattt tttatggatg agatagagag tgagcgagac actcatagca
    77521 aaggcgataa agacgattaa ccagaaggca tttggctctc cgtttagggg gatttcatta
    77581 tccttaaagt tcatcccgta ggcagaaaag accatggttg ggatggacat gacgatggtc
    77641 acaagggcca aggttttcat gatgttgttc tggttgttag aaatgataga ggcaaaggtc
    77701 tctgtcatag aatgcaagac gtttccataa atatctgcca tctcgatggc ctgttgggtt
    77761 tcaatcaggg tgtcttcaag caggtcttcg tcctcaaggt atttcttgat attgctggtt
    77821 gaactggtca atttcttaat cacgcgctca tttgttttga gggaggcctt gaaatagacg
    77881 atagtttttt ccaattccat gagctcaatc aattcttcat tacgagttga ttgatgcagt
    77941 tgactttcga tttgttcact cttgcggtcg attgaacgaa gggctgttag gtaaagctct
    78001 gcattgcgat aaagaatttg aaagataaaa cgtgaacgca tgaaggtata gaaattacgc
    78061 aatcgacggt tgataaagac atcaaggaca ggtagtggtt ccaaacacgt agtgataatg
    78121 gtttcctcag tgatgataat accaagcggg atggttacgt agtaggtgcg gttatttctt
    78181 tcctccgtga ccggcacgtc tacgataatc agggtatact cgtcttcaat ggtaatacga
    78241 gacatttctt ccgcatcgag cggtgctcga aggtcggcaa tatcaatatc gaaggtgttg
    78301 gcgatttcga gtgattcatt ttgagtcgga ttgacgagat tgatccaagt acccggttca
    78361 agcgtatcga tctctttaaa ttcagttgtt gtagagagaa aaacttgttt catatccctt
    78421 atcctttctc atttttcaga ttttttcaca ctgtactatt atactacaaa atcggccttt
    78481 tgggtaatag aatctcactt tttttggtat aatggtaagc aataatggac tagaaagaac
    78541 aaagatgcaa gataaaattg tcattcatgg ggcgcgtgcc cataatttaa aaaatattga
    78601 tgtggagatt ccgcgagaca agttggttgt cgtgactggc ttgtcaggtt cagggaagtc
    78661 cagtctggct tttgatactc tctatgcgga gggacaacgt cgctatgtag agagtttgtc
    78721 tgcctacgct cgtcagttct tgggaaatat ggaaaaacca gatgtagatg ccattgatgg
    78781 tctcagccca gctatttcca tcgaccagaa aacgactagt aaaaatcctc gctcgacggt
    78841 gggaacgacg actgaaatca atgactatct gcgtctcctc tacgcacgtg tggggacgcc
    78901 ttactgtatc aacggacatg gagctatcaa tgcttcttct gtggagcaaa tcgttgataa
    78961 ggttttggag ttacctgaac gccagcgctt gcagatcttg gctcctgtca tccgcaagaa
    79021 aaaaggccaa cataagagtg ttatcgagaa ggttcagaaa gacgggtatg ttcgtgttcg
    79081 tgtggatggg gaagtctatg atgtgaccga agtgccagag ttgtctaaga gcaagcaaca
    79141 caatatcgat gtcgtggttg accgtattgt tatcaaggag ggcattcgta gccgtctctt
    79201 tgattccatt gaagctgccc ttcgtatcgc agaaggttat gtgattatcg acaccatgga
    79261 cgactctgag ttgttgttct ctgagcatta tgcctgtcca gtttgtggat ttactgtccc
    79321 agagttagaa cctcgtctct tctctttcaa tgctcccttt ggctcttgta gtgagtgtga
    79381 cggcttgggg attaagctgg aggtggatac tgatttggta gtgccagatg ccagcaaaac
    79441 cttacatgag ggagcgctgg caccttggaa tcctatctca tccaactact atccaaacat
    79501 gttagagcag gccatgaaag tctttggagt ggctatggat aagccttttg aggacctgtc
    79561 agaagaagat aagaacttga ttctctacgg ctcagatggt aaggaattcc atttccatta
    79621 tgaaaatgaa tttggtggtg tgcgcgatat cgacattccg tttgagggag ttatcaataa
    79681 tatcaaacgt cgttaccatg aaaccaatag cgattacact cgcactcaga tgcgtctcta
    79741 tatgaatgag ctgacctgcg gaacctgtca aggctatcgt ctcaatgacc aggccttgtc
    79801 tgtccgtgtg ggcggccagc aagggccaca tattggagaa atctcagacc tgtctatcgc
    79861 tgaccacttg gacttggtga gccagttaac tttgtctgaa aatgaagcca tcattgctcg
    79921 tcccattctc aaggaaatca aggatcgttt gaccttcctt aataatgtgg gtcttaacta
    79981 tctaaccctg tcacgttcag caggaaccct ttcaggtggg gaaagtcagc gcattcgttt
    80041 ggcaacccag attggttcca acctatcagg tgtcctctat atcctagacg agccgtcaat
    80101 cggtcttcac cagagggaca atgaccgcct gattgccagt ctgaaaaaga tgcgtgactt
    80161 gggcaatact cttatcgtgg tggaacacga cgaagatacc atgcgtgaag ctgattatct
    80221 gattgacgtt ggtcctggtg ccggtgtttt tggtggtgag attgttgcag caggtacacc
    80281 taagcaagtg gctcgcaaca gcaagtctat cacaggtcag tacttgtcag gcaaacgtgt
    80341 catcccagta ccagaagagc gccgtgtcgg aaatggtcgt tttattgaag tgacaggagc
    80401 gcgtgagaac aacttgcaaa atgtcacggc tcgctttcca ctaggaaaat ttatcgcagt
    80461 gacaggtgtg tcgggttcag ggaaatcgac tctaatcaac agcattctca aaaaagccat
    80521 tgcccagaag ctcaaccgta attcagacaa acctggtaag tttaagacta ttacagggat
    80581 tgagcatgtc gaccgtttga ttgatattga ccagagccct atcggacgga cgccgaggtc
    80641 taacccagct acctatacag gagtttttga cgatatacgt gacctttttg ctcagacaaa
    80701 tgaagccaag attcgaggct acaagaaggg gcgcttcagt ttcaacgtca agggaggtcg
    80761 ctgtgaagct tgctcaggtg acgggattat caagattgag atgcacttct tgccagatgt
    80821 ttatgtggct tgtgaagttt gccacggaac ccgctataac agtgaaaccc tagaagttca
    80881 ctacaaggaa aagaatattt cgcaggtctt ggatatgacg gtcaacgatg cggtagaatt
    80941 tttccaacac attccgaaaa ttcaacgcaa actccagacc atcaaggatg taggtctagg
    81001 ctatgtgacc ttgggacagc cagctaccac cctttctggg ggagaagccc aacgtatgaa
    81061 gttagctagc gaactccaca aacgctcgac aggaaaatct ttctacattc tggatgagcc
    81121 gacgacaggg cttcatacag aggacattgc tcgcctgctc aaggttttag ctcgctttgt
    81181 agacgacggc aatacagtcc tcgtcatcga gcacaatctg gatgttatca agacggcaga
    81241 ccatatcatt gacttgggac ctgagggcgg tgtcggtggt ggaaccatca tcgtaacagg
    81301 aactccagaa gaagtagctg ccaacgaagc cagctataca ggacactatt tgaaaggaaa
    81361 gttacatcat gaataaacgc gtacaagcat ttctagctaa aatgcaagaa aaagaactag
    81421 atggtatcat catcaacaat cttaaaaacg tctattattt gactggtttt tggggctcaa
    81481 acggaacagt ctttatcagc cgtgaccgtc aggtcttagt gacagactct cgctatatca
    81541 tcgcagctaa gcaagaaacc agtggttttg agattgtggc tgatcgtgat gaattggctg
    81601 tcattgcagg aattgttaag gacatgaact tgactcgtat cggttttgaa gatgagattt
    81661 cagtgtctta ttaccaccgt atgcaggcag cttttgcagg tttgaacttg cttccacaaa
    81721 ctcagtttgt ggaaggtctt cgtatgatta aggatgaggc agagattgca gcgattcgca
    81781 aggcttgttc tatctcagac caagctttcc gcgatgcgct tgactttatc aaaccaggaa
    81841 aaactgaaat tgagattgcc aacttccttg atttccgcat gcgtgagttg ggagcatctg
    81901 gcttatcttt tgatacgatc ctagctagcg gtatcaattc ttctaaaccc catgcccatc
    81961 caatgcacaa accagtggag ttgggagaag ccattaccat ggacttcggc tgtctctatg
    82021 accactatgt cagtgatatg acccggacta tctatctagg gcatgttagc gatgagcagg
    82081 cagagattta caatacggtt ctaaaagcta accaagcctt gattgaccaa gctaaggcag
    82141 gcttaggttt ccgtgacttt gacaaaatcc ctcgtgatat tatcattgag gcaggttatg
    82201 gtgactactt tactcacggc attggccacg gtattggtct ggatatccat gaggaaccct
    82261 actttagtca gacttctaca gaaactatta agacaggtat ggccttgacc gatgaaccag
    82321 gtatctatat cgaaggcaaa tatggcgttc gtatcgagga tgatatcctg attacagaga
    82381 caggttgtga attattgacc ctagctccaa aagagttgat agtcatttag ttgtttgtca
    82441 agaaaaaagt acgaaaatga cgaaaaaagt caaaaaaaat taaaaatagg tcgcaagtcg
    82501 gatgtttttt atggtataat agactaaact gatagtaaca tgtagcgaaa ggggtaggta
    82561 catgattaaa atttatacag tctcaagttg tactagctgt aaaaaagcaa aaacctggct
    82621 caatgcccac cagttaagtt ataaagaaca aaaccttggt aaagaaggaa ttacgagaga
    82681 agaattactg gatattctaa ccaaaacaga taacggaata gccagcatcg tttcgtctaa
    82741 aaatcgctat gccaaagccc ttggagtgga tattgaagat ttgagtgtca atgaagttct
    82801 caatctgatt atggaaacac cgagaatttt aaagagccca atccttgtag atgaaaaacg
    82861 cctgcaagtt ggctacaagg aagacgatat tcgtgccttc ctaccacgct ctgtccgtaa
    82921 tgtagaaaat gcagaagcac gtttgcgtgc agctctataa acatcaaggc tgggagcact
    82981 tcccagtctt attctatttt aatttcaaaa agaaagaaga aagaaatgaa aaaaatagtt
    83041 cttgttagtc tagctttcct ttttgtcctg gttggttgcg gacagaaaaa agaaactgga
    83101 ccagctacaa aaacagaaaa agatacgctt cagtcggcat tgccagttat tgaaaatgct
    83161 gagaagaata cagttgtaac taagactttg gtcttgccca agtcagatga tggtagccag
    83221 cagacacaaa caattactta caaagacaag acttttttga gtctagctat ccaacaaaaa
    83281 cgtccagtct ctgatgagtt gaagacttat attgaccaac atggagtgga ggaaactcaa
    83341 aaagctcttc ttgaagcgga ggagaaggat aagtctatca ttgaagctcg taaattggca
    83401 ggtttcaaac ttgaaacaaa actattgagc gcaacggaac ttcaaacaac gactagtttt
    83461 gattttcaag ttctggatgt caagaaggct tcccagttgg aacatctgaa gaatattggt
    83521 ttggaaaatc ttttgaaaaa tgaaccaagc aaatatattt cagatagatt ggcaaatggc
    83581 gcgacagaac aatagaaaat ccaaataaat agactgcctg aattgtagaa ggtaaggaat
    83641 tatgctataa tggtactatt ctaaggaaag agggtgttag aatgggattt actgaagaaa
    83701 cagtacgttt taaattggac gattccaata aaaaagaaat tagcgaaact ttgacagatg
    83761 tttatgcttc gttgaacgat aagggttaca acccaatcaa ccaaatcgta ggttacgtat
    83821 tgagtggaga ccctgcctac gttcctcgtt ataataatgc acgaaatcaa atccgtaagt
    83881 atgagcgtga tgaaatcgtt gaggaattgg ttcgctacta cctcaaagga caaggagtcg
    83941 atctataacc tatgagaatt atgggattgg acgtcggttc aaaaacggta ggggtggcga
    84001 ttagcgatcc gcttggtttt acagctcaag ggcttgaaat catccagata aatgaagaac
    84061 aaggccaatt tggttttgac cgcgttaagg aattggttga tacttacaag gtggaacgat
    84121 ttgtagtggg cttgcctaaa aacatgaaca atacaagtgg accgcgcgta gaagctagtc
    84181 aagcctacgg agcaaagcta gaagagtttt ttggtttacc agtagactat caggatgaac
    84241 gcttgacaac agtggctgct gagcgcatgt tgattgaaca agcagatatc agtcgcaata
    84301 agcgcaagaa agtcattgat aagttagcag ctcagctgat tttacaaaat tatttagata
    84361 gaaaatttta atataaagga gaggctatgt cacacgatca taaccacgac cacgaagaac
    84421 gtgaactaat cacactagta gatgagcaag gaaatgaaac cttgtttgaa atccttttga
    84481 caattgatgg aaaagaagaa tttggtaaaa actatgttct tctagtacca gttaacgcag
    84541 aagaagacga agacggacaa gttgaaatcc aagcttactc attcatcgaa aacgaagatg
    84601 gaacagaagg cgaattgcaa ccaatcccag aagactcaga agacgaatgg aacatgattg
    84661 aagaagtctt caacagcttt atggaggagt gatacagtct gggagactgt atcagcccaa
    84721 ctcccagaaa tggggaagag ttggaacatc cagtggatgt ttttagccca gttcctttaa
    84781 ataagagaga actggtaagt ccgggggacg tttttagcct gacgctaaaa ataaaaacag
    84841 tcagtaagtt cgggggatgt tttagcccag ctccttgaaa taagatagag ctggtaagtc
    84901 tgagaaactg tatcagccca actcccagaa atggggaaga gttggaacgt ccagtgaaca
    84961 tttttacccc aactcttaga aattgagaag agttggaaca tctagtggat gtttttagcc
    85021 catattcaca ttcatagtag ctagttatta gctaaccagg taagaggtcg ggacgaaaat
    85081 cctggccttg tttttattag taaccatact ttaatgcgat aattgattgg acttttgtca
    85141 aggagatgtg tatgtttgaa gtagaagaat ggctccatag tcggattggt ttgaattttc
    85201 gatcaggttt gggccgaatg cagcaagcgg tggatttgtt aggaaatcct gagcagtctt
    85261 accctattat ccacgtaaca gggactaatg ggaaaggatc taccattgct tttatgaggg
    85321 aattatttat ggggcatggc aaaaaagttg cgacctttac ctcccctcat atcgtctcta
    85381 tcaatgaccg aatctgcatt aatgggcaac ctatagcaga cgcagacttt atccgtttga
    85441 ctgatcaggt caaggagatg gagaaaacgc ttctgcaaac tcctgcccag ttgtcctttt
    85501 ttgaattgct gaccttagtt gcttttcttt attttaggga gcaagaggtg gatttggttt
    85561 tattagaagt gggaattggt ggcttacttg acacgaccaa tgtggtaact ggagagcttg
    85621 ctgtcatcac ctccattggg cttgaccatc aagaaacctt gggtgatagt ctagaagcaa
    85681 ttgcagagca gaaagctggt attttcaagg ctggtaaaaa ggcagtgatt gcgaaattgc
    85741 ctccagaagc tagacttgtc tgtcagaaaa aagctgaatc tttagctgtt gacctttatc
    85801 aggcaggtca agatttttca gtgctgaatg gtgatttttc aagctcttta ctaaatcttt
    85861 cacagctgaa cataggctta gaaggagcct atcagcagga gaatgcggcc ttggcgttgc
    85921 aaacttttct tctttttatg ggagaaagaa aggaagctat tgatgaacag gctgtaagaa
    85981 aggccttgga acagacccat tgggctggtc gcttggagcg tattcgccca cagatttact
    86041 tggatggtgc tcataacctc cctgccttga ctcgcttggt tgagtttatc aaagaaaaag
    86101 agcaggaagg ctatcgacct caaatcctct ttggatcctt gaaacgtaag gattatcaag
    86161 ggatgttggg ttatctgact gaaaatttac ctcaagtgga actcaaaatg accggctttg
    86221 actatcaagg gtctttggac gagacagatg taacaggtta ccatgtaatt ccctcttacc
    86281 gagaatttat cagcagtttc gaagaaaggg cagacgctca agacttgctg ttcgttacag
    86341 ggtctctcta ttttatctca gaagtacggg gctacctgct ggaccgtgag cagataaatt
    86401 gacccccttg tttgaacttg ttatactagg ggaattgctg gttagagaaa atttctctaa
    86461 attggtagca gaaaggaaat tcatcatgaa attaaaaaga ttcacacttt ctcttgcttc
    86521 tctagcaagt tttagtctct tagtagcttg ttcacaaaga gctcaacagg ttcaacagcc
    86581 tgttgctcag cagcaggtcc aacagcctgc tcaacagaat accaatactg caaatgcagg
    86641 aggtaaccaa aatcaagcgg ctccagtaca aaaccaacct gttgctcaac cgaccgatat
    86701 tgatgggact tatactggtc aggatgacgg agaccgtatc actttagtgg taactggaac
    86761 gactggtaca tggactgagc tcgaatctga cggggatcag aaagtcaaac aggttacatt
    86821 tgattcagca aatcaacgca tgattattgg cgatgatgtc aaaatttaca ctgtaaacgg
    86881 taatcaaatc gtcgtagatg atatggatag agacccatcg gaccaaatcg ttttaactaa
    86941 ataagactat gcaagtagaa agggctggat ttttcagcct ttttactttt acctagaaaa
    87001 taatcataaa tacttgcctt ctaccgaata cctgcgttat actagtatca attacttgtt
    87061 tttagcattc aaactatcaa ggaggggata tgaaatatag gaaatttcaa ttattgatgt
    87121 ccaagtatgg ctttagtctt tcgattatgc tacttgaact ttgtcttgtt tttggtctct
    87181 ttctttattt aggacgcatg gctcccattt tatggattac tgtcctcatt ctactgagta
    87241 tcatcacaat catttcgata gtcaaccgta atacgactcc tgagaataag gtaacctggt
    87301 tgttagtagc ctttgtgcca gtatttggtc ccttgctcta tctgatgttt ggtgaaaggc
    87361 gattgtccaa aaaagaaatc aaacaactga agaagctagg ctctatgcat ttccaagaag
    87421 caaatagcca gctactaaaa gagaaattaa aagaaagtga caaggcagct tatggagtca
    87481 tcaagtcctt attgagtatg gataccaatg ctgacatcta tgatcaaact gcctctacat
    87541 tttttcctaa cggagaagct atgtggaaaa agatggtaga agatcttaaa aaggctgaga
    87601 aatttatttt cttggaatat tacattatag aagaaggttt gatgtggaat cgcatactag
    87661 atatactaga gcaaaaggta gctcagggtg tagaggttaa gatgctctat gatgatatcg
    87721 gctgtatggc tactttaaca ggagattatg cacatcgact tcgtcagctg ggcatcgagg
    87781 cccataaatt caataaagtt attcctcgtt tgacagtggc ttataataac agagatcata
    87841 gaaaaatatt gattgttgat ggtcagatag cctatactgg tggggtcaat ctggcagatg
    87901 agtacattaa ccacgtcgag agatttggtt attggaagga tagtggaatt cgcttagacg
    87961 gactagcagt aaaagctctg acacgcttat ttttgaccac ttggtacatt aatcgaggag
    88021 aaattagtga ttttgatcaa tatcatttag aaaatcattc tatcccgagt gacggtttaa
    88081 ccattccata cggaagtgga cccaagccaa tttttcgagc gcaggtaggg aaaaaagttt
    88141 atcagagttt aatcaatcaa gcaacagaat cggtctatat tacgacacct tatttgatta
    88201 tagattatga tttaacagag acaatcaaaa atgcagctat gagaggggtc gatgttcgaa
    88261 ttatcacccc ttacatacca gataagaagt tcattcagtt agtcacgaga ggagcttatc
    88321 ccgaccttct ttctgctggt gttcggattt atgagtatag tccaggtttt attcatagta
    88381 agcagatgtt ggtagacgaa gattttgcgg tggtggggac aatcaatctc gactaccgga
    88441 gcttggtaca ccattatgaa aatgcagtct tactctataa aactccttct ataagggaaa
    88501 tcgcccgaga ttttcgaaat atatttgcag attctcagga agtctatcct cattctatca
    88561 aaacgagctg gtatcaaaag cttgtaaaag aaatcgccca actattcgcc cctatcttat
    88621 aagaaatcta gaacttagga tacaaaccag acctattttt cttgtctttt acgaatagaa
    88681 agaaagagga ggggaattca tgctaactaa ggaagaagtg aatgatatga ttgagttcaa
    88741 acagacacat ttacaccgct ttcgggaaat tgaaaccttt gtgaaactat gcaaaaaatc
    88801 actcaaacag ccatcgcaag ctgacaatcc taggactttt tgatatacta agacagataa
    88861 attgaacagg agaaacgata tgagtgtgta tggtagagta gaagaagttc ataaggagaa
    88921 tcgtgaacct ctagaatacc aaattgaaca agaatcgcat catcgtgaat caagtcgtct
    88981 tcctttggtg aaaattttac tatggagtac gcttgtaacg gggataactc taggagtacc
    89041 gctattactc gacttaatga gtgcacaaga agtgcaggat ttttatgcag gttgggcgct
    89101 tcatcagaca gggaagattt acagcgacta ttatggaagt caaggtttgc tttattattt
    89161 gctgacttac gtgagtcagg gcggattttt ctttgccatc tttgagtggt tagccttggt
    89221 agcaggcgga tttttccttt ttagatcagc ggacaccttg acaaatcaag gagaccaagc
    89281 tggacaactg gtgactattt tttacatgct agttacaggt cttgcttttg gtggaggcta
    89341 tgcgactctt ttagcgcttc ctttcttatt cgcagccttt agtttagttg cggcttacct
    89401 aagcaatcca agccatgata agggatttgt acggattggg ctagctttgg caggcggatt
    89461 tttctttgct cccttatcat cgctcctgtt tattgctgta gtgagtttag gcttgttggt
    89521 ctttaacctt gggcatagac gctttgcgca tgggttttat cagtttcttg cagtggcttt
    89581 aggtttttca cttgtctttt atccaactgc ctactatagt gctgcaacag gaagttttgg
    89641 ggatgcgatt agtggtattc gttatcctat tgacagtatt cgctttgatt ttacttctaa
    89701 aattttagag aatatgtttt tttatggctt gttgtccctt ggtttgggat ttgtggtttg
    89761 tatcttttta ggtctctttc aatccaaacc ctttaaacta tacgtcattt cggttcctgc
    89821 aagtcttgtg gtaattttag gtttgatttt acttttcttt tcacaagagc ctctgcacgc
    89881 ttcttatttg atggtcgtct tccctgtttt cctactttta ttggtaacca atattaagag
    89941 tcaacagagg gggcgtagtg ctagaagaag ccgaagagaa acgccagtta gcctatggag
    90001 tcgtttcttc aaaggaaatc tatatctgct agtttttggg tttgtctatc ttttgtctgt
    90061 tccttttttg atgaagtttg tcctttatcc agtaccttat caagaacgta atcgtcttgc
    90121 tgatttggta aaagaggaga caaatacgga agatgctatc tatgcatggg atgatactgc
    90181 gactctttat cgtaagagtg agcgcttgtc gccatcggcg attttgtccc cgttgcacta
    90241 tacagcaact gaggaaaatc gtaataagtt acttaatgac ttgaaagaaa aacaacctaa
    90301 ggtgattgtg gtaaatgaca aggtggaagt ctggtctgaa gtggaaacac tcttaaaaga
    90361 aaattaccaa caagtaaaga ctgattactc agagtttaaa gtctataaaa ttaaataacc
    90421 aaatcaatat cttgtgtatt tttaaaaatt ttaagatttt taacacaaga tattgatttt
    90481 tctttttaga gtggtataat actttttaga aagaacattt tagaaaagag catgcatatg
    90541 attgcactag aagaaaaaat tacaattttg ccaactctct tcgtcgagaa acgagatggg
    90601 agacgtgttg tatttgatgt ggacaagatt gacaaggctc tccacaaggc agctgacaag
    90661 gttatggatg tgacacccct ggttgaaaaa cgcctcaatg acctgactga gagaattatt
    90721 acagaaattc atagtcgctt tccacaggga attaagattt acgaaattca aaatatcgta
    90781 gaacatgaac tccttgaagc caaagaatat gcgctggctg aggagtatat tacttatcgg
    90841 acacagaggg attttgagcg ctcaaaagcg acggatatca actttagtat tcataaactt
    90901 ctcaacaaag accagacagt tgtcaatgaa aatgctaata aagacagtga tgtctttaac
    90961 actcagcgtg atttgacagc agggattgtt gggaaatcaa tcggactgca aatgcttcct
    91021 aagcacgtag ccaatgccca ccaaaagggg gatatccact atcacgattt ggactacagt
    91081 ccctataccc ctatgaccaa ctgctgtttg attgatttta agggtatgtt ggaaaatggt
    91141 tttaagattg gaaatgcaga ggtagagagt cccaagtcta tccagactgc gacagcacag
    91201 atttctcaaa tcattgccaa cgttgcttct agccagtacg gtggctgttc agctgaccgt
    91261 atcgatgaaa ttttggcgcc ttatgcagag aagaactatc aaaaacatct caaagatgca
    91321 gaagagtggg tattgcctga aaaacgggaa gattacgctt ggaagaaaac gcaaaaggac
    91381 atctacgatg ccatgcaatc tcttgagtat gaaatcaata ctctcttcac ttcaaatgga
    91441 caaacacctt ttacttcgct aggttttggt ctgggaacca gtcgttttga acgagaaatt
    91501 caaaaagcta ttttaaacat tcgcatcaag ggtcttggtt cagaacaccg tacggctatc
    91561 tttcctaaac ttattttcac tctgaaaaga ggccttaatt tagaagaagg aactcccaac
    91621 tacgacatca agcagttggc tcttgagtgt gcaaccaaac ggatgtatcc agatgtttta
    91681 tcttacgata agattgttga cttgacagga tccttcaagg tgcctatggg ttgccgttct
    91741 ttcctccaag gatggaagga tgaaaatggt gtagaagtca attcaggtcg catgaatctg
    91801 ggtgttgtga cggttaatct gcctcgtatt gctcttgagt ctgaaggtga tatgaataag
    91861 ttctgggaaa tcttcaacga gcgaatgaat atcgcagaag atgctcttgt ttaccgtgtc
    91921 gaacgcacta aagaggcgac accagcgaat gctcctatcc tttatcagta cggtgctttt
    91981 ggccatcgtc taggtaaaga agaaagtgtt gaccagctct ttaagaatcg tcgtgcgacc
    92041 gtttcgctgg gctatatcgg cttgtatgaa gtagcgacag ttttctttgg taacagctgg
    92101 gaaagtaatc cagatgctaa ggaattcacg ctagacatca ttcacgatat gaaacgccgt
    92161 gtagaagagt ggtcagacca atatggctac catttctcta tctactcaac accatccgaa
    92221 agtctgacag accgtttctg ccgactagat atagacaagt ttggctctat tcctgatatc
    92281 acagacaagg aatactacac caactctttc cactacgatg ttcgtaaaaa tccaacaccg
    92341 tttgaaaaat tggactttga gaaagtctat ccagaagcag gtgcgtcagg tggtttcatc
    92401 cattattgtg agtatccagt ccttcagcaa aatccaaagg ccttggaagc tgtctgggat
    92461 tatgcttatg accgtgtagg ctatctaggc accaatactc cgattgaccg ttgctacaag
    92521 tgtgactttg aaggggattt tgaaccaact gagagagggt ttgcttgtcc aaactgtggc
    92581 aatagcgacc ctaaaacagt agatgtggtg aagcgaactt gtggctacct aggtaatcct
    92641 caagcaagac cgatggtcaa cgggcgtcac aaggaaatcg ctgcgcgtgt caaacatatg
    92701 aatggttcaa cgattaaaat agctgggcat caagtaacaa attagaaaga aatgaaatgg
    92761 gaaaatatca actagacgat aaggggcgcg cacaagtgac ccgttatcac gagaaacact
    92821 ctaaaggtgg agctggtaag aaagaacgct tgcttagctt cagagaacaa tttttaaaca
    92881 agaacaagaa aaaataaaag tgagagccag ctctcgcttt tctcatagtg ggaggtaagg
    92941 atggaattac gcagaccaag attagcggat aagaaagctg ttttagatat gatgacagag
    93001 tttgaaaaga gccaatcagc ccatgatgga ggattttggg atacagagaa ttttgtgtat
    93061 gaagagtggt tggaaagcaa tcaggaacag gaaatgggga ttaatctgcc tgaaggatgg
    93121 gttcctgcaa ttcagttagt ggctttttct gagaaaggtc aagcagttgg atttcttaat
    93181 ctccggttgc gcctcagtaa ctttttacta gaagaaggtg ggcacattgg ctactccatc
    93241 cgtccatctg aaagaggcaa gggttatgca aaagagactc tccgtcaggg cttgcaagtt
    93301 gctaaggaaa agaacatcaa gaaagctctg gtgacctgta gcgtgaataa tcctgctagc
    93361 agagcagtca ttctagcaaa tggtggaata tttgaggatg ctcacaatgg agtcgagcgt
    93421 tattggatag aggtagcgaa tgaataatcc aaaaccacaa gaatggaaaa gcgaggaact
    93481 tagtcaaggt cgtatcattg actacaaggc ctttaacttt gttgatggcg aaggcgtgcg
    93541 taactctctc tatgtagcag gctgtatgtt tcactgcgag ggatgttata atgttgcgac
    93601 ttggtctttt aatgctggca ttccctatac agcagaatta gaagagcaga tcatggcaga
    93661 ccttgcccaa ccctatgttc aaggcttgac tttgctggga ggggaacctt ttctcaatac
    93721 tggcattctc ttgcctctag ttaaacgcat ccgaaaggaa ttgtcagaca aggacatttg
    93781 gtcctggacg ggctacactt gggaagaaat gatgttggaa actccagata aactggaact
    93841 cttatcattg attgacattc ttgtcgatgg acgatacgat cgaactaaga gaaatctcat
    93901 gctccagttt cgaggttcgt ccaaccaacg aattatcgat gtgcaaaaat cgctcaaaag
    93961 tgggcaagta gtgatttggg acaagctcaa tgacggaaaa gaaagctatg aacaggtgaa
    94021 gagagaatga agaaaaaaga cttagtagac caactagtct cagagatcga gacggggaaa
    94081 gtcaggacac tgggaatata cggtcatgga gcttcaggta aatcaacctt tgcacaggaa
    94141 ttgtaccaag ctttagattc tactacagta aatttgctag aaacagatcc ctatatcacc
    94201 tcaggacgcc atctggtagt acccaaggac gcgccgaatc aaaaggtgac agccagtctg
    94261 ccagtggcgc atgaactgga gagtttgcag agagatatcc ttgccttgca ggcgggtatg
    94321 gatgtcttga caattgaaga accttggaag gctagtgagg tcttgtctgg agccaaacca
    94381 attttgattg tcgaagggat gtctgttggc tttctaccca aggaactctt tgaaaaaacc
    94441 atctgtttct acacggatga ggagaccgaa ttaaagcgac gccttgctag agatacgact
    94501 gtgagaaatc gcgatgcatc ctttatattg gctagccatc agatgagacg ggagcagtat
    94561 ctgcgatact ataaagaaac tgagtctaag gcggatatct tagtggacca atcagaagat
    94621 aaatttgatg tcaagaggac ttaacttatg tatagaagaa atatagaaga aaatccctaa
    94681 ttttagaaag aaaaagtagg aaaacagttt catccccaaa aaacgaaaaa acctaacaaa
    94741 tcccttgcaa tcgcagggga tttgtgttat tctattatgg tgctgtaaat tacagcctta
    94801 gttttgatgc aagaggttgc gacacgctcg gttgcattgc cacgcaacac cgcgtcggtt
    94861 ttcttgtgga gctagcctat tatcttaaat agacgaaaag gagaaaaaga tggcaaacaa
    94921 aaaaatccgt atccgtttga aagcttacga acaccgtacg cttgacacag cggctgcaaa
    94981 aatcgtagaa tcagctactc gtacaggtgc acaagttgcg ggtccaatcc cacttccaac
    95041 tgaacgtagc ctctacacaa tcattcgtgc gactcacaaa tacaaagact ctcgcgaaca
    95101 atttgaaatg cgtacacaca aacgtttgat cgatatcgtt aacccaactc aaaaaacagt
    95161 tgatgccttg atgaaattgg atcttccaag tggtgtaaac gtagaaatca aactttaatc
    95221 taaaatataa aagagcagag gctggtgttt caatctaatt gaacacgggc taaacttggt
    95281 gtgaaaaaga taaacttcct cgcgtctgct agacactgtg tcagtttcct attttcacgt
    95341 tgagtttgac gccctttgta tcttagactt gagcataaaa aacgctcgtt aaaaactttt
    95401 tgaataaaaa tatagaaaag gaactatttt ctcatgacaa aaggaatctt agggaaaaaa
    95461 gtgggaatga ctcaaatctt cactgaagct ggcgaattga tccctgtaac agttattgaa
    95521 gcaactccaa acgttgttct tcaagttaaa actgttgaaa cagacggata caacgctatc
    95581 caagttggtt tcgatgacaa acgcgaagta ttgagcaaca aacctgctaa aggacatgta
    95641 gcgaaagcta acacggctcc taagcgcttc attcgtgaat tcaaaaacgt tgaaggcttg
    95701 gaagttggtg ctgaaattac agttgaaaca ttcgcagctg gagatgttgt tgatgtaact
    95761 ggtacttcta aaggtaaagg tttccaaggt gttatcaagc gccacggaca atcacgtgga
    95821 ccgatggctc acggttctcg ttaccaccgt cgtccaggtt ctatgggacc tgttgcacct
    95881 aaccgcgtat tcaaaggtaa aaaccttgca ggacgtatgg gtggtgaccg cgtaacaatt
    95941 caaaatcttg aagttgtaca agttgttcca gaaaagaacg ttatccttat caaaggtaac
    96001 gtaccaggtg ctaagaaatc tcttatcact atcaaatcag cagttaaagc tggtaaataa
    96061 taaagaaagg ggaaatcagt cacaatggca aacgtaacat tatttgacca aactggtaaa
    96121 gaagctggcc aagttgttct taacgatgca gtatttggta tcgaaccaaa tgaatcagtt
    96181 gtgtttgatg taatcatcag ccaacgcgca agccttcgtc aaggaacaca cgctgttaaa
    96241 aaccgctctg cagtatcagg tggtggacgc aaaccgtggc gtcaaaaagg aactggacgt
    96301 gctcgtcaag gttctatccg ctcaccacaa tggcgtggtg gtggtgttgt cttcggacca
    96361 actccacgtt catacggcta caaacttcca caaaaagttc gtcgcctagc tcttaaatca
    96421 gtttactctg aaaaagttgc tgaaaacaaa ttcgtagctg tagacgctct ttcatttaca
    96481 gctccaaaaa ctgctgaatt tgcaaaagtt cttgcagcat tgagcatcga ttctaaagtt
    96541 cttgttatcc ttgaagaagg aaatgaattc gcagctcttt cagctcgtaa ccttccaaac
    96601 gtgaaagttg caactgctac aactgcaagt gttcttgaca tcgcaaatag cgacaaactt
    96661 cttgtcacac aagcagctat ctctaaaatc gaggaggttc ttgcataatg aatttgtatg
    96721 atgttatcaa aaaacctgtc atcactgaaa gctcaatggc tcaacttgaa gcaggaaaat
    96781 atgtatttga agttgacact cgtgcacaca aacttttgat caagcaagct gttgaagctg
    96841 ctttcgaagg tgttaaagtt gccaatgtta acacaatcaa cgtaaaacca aaagctaaac
    96901 gtgttggacg ttacactggt tttactaaca aaactaaaaa agctatcatc acacttacag
    96961 ctgattctaa agcaatcgag ttgtttgctg ctgaagctga ataatctaag gaggaaatat
    97021 cgtgggaatt cgtgtttata aaccaacaac aaacggtcgc cgtaatatga cttctttgga
    97081 tttcgctgaa atcacaacaa gcactcctga aaaatcattg cttgttgcat tgaagagcaa
    97141 ggctggtcgt aacaacaacg gtcgtatcac agttcgtcac caaggtggtg gacacaaacg
    97201 tttctaccgt ttggttgact tcaaacgtaa taaagacaac gttgaagcag ttgttaaaac
    97261 aatcgagtac gatccaaacc gttctgcaaa catcgctctt gtacactaca ctgacggtgt
    97321 gaaagcatac atcatcgctc caaaaggtct tgaagtaggt caacgtatcg tttcaggtcc
    97381 agaagcagat atcaaagtcg gaaacgctct tccacttgct aacatcccag ttggtacttt
    97441 gattcacaac atcgagttga aaccaggtcg tggtggtgaa ttggtacgtg ctgctggtgc
    97501 atctgctcaa gtattgggtt ctgaaggtaa atacgttctt gttcgtcttc aatcaggtga
    97561 agttcgtatg attcttggaa cttgccgtgc tacagttggt gttgtcggaa acgaacaaca
    97621 tggacttgta aaccttggta aagcaggacg tagccgttgg aaaggtatcc gcccaacagt
    97681 tcgtggttct gtaatgaacc ctaacgatca cccacacggt ggtggtgaag gtaaagcacc
    97741 agttggtcgt aaagcaccat ctactccatg gggcaaacct gctcttggtc ttaaaactcg
    97801 taacaagaaa gcgaaatctg acaaacttat cgttcgtcgt cgcaacgaga aataatatta
    97861 aactagtcgc ttaagcaact agtaaatccg ccagctcggt agcgctccat aggagtgcaa
    97921 gccgctgtgg tacaacattt aaaggagaaa atataaaaat gggacgcagt cttaaaaaag
    97981 gacctttcgt cgatgagcat ttgatgaaaa aagttgaagc tcaagctaat gacgaaaaga
    98041 aaaaagttat taaaacttgg tcacgtcgtt caacgatctt cccaagtttc attggttaca
    98101 ctattgcagt ttatgacgga cgtaaacacg tacctgttta catccaagaa gacatggtag
    98161 gccacaaact tggtgaattt gcaccaactc gtacttacaa aggtcacgct gcagacgaca
    98221 agaaaacacg tagaaaataa ggagaacata aatggcagaa attacttcag ctaaagcaat
    98281 ggctcgtaca gtacgtgttt cacctcgtaa atcacgtctt gttcttgata acatccgtgg
    98341 taaaagcgta gccgatgcaa tcgcaatctt gacattcact ccaaacaaag ctgctgaaat
    98401 catcttgaaa gttttgaact cagctgtagc taacgctgaa aacaactttg gtttggataa
    98461 agctaacttg gtagtatctg aagcattcgc aaacgaagga ccaactatga aacgtttccg
    98521 tccacgtgcg aaaggttcag cttcaccaat caacaaacgt acagctcaca tcactgtagc
    98581 tgttgcagaa aaataaggag gtaaaatcgt gggtcaaaaa gtacatccaa ttggtatgcg
    98641 tgtcggcatc atccgtgatt gggatgccaa atggtatgct gaaaaagaat acgcggatta
    98701 ccttcatgaa gatcttgcaa tccgtaaatt cgttcaaaaa gaacttgctg acgcagcagt
    98761 ttcaactatt gaaatcgaac gcgcagtaaa caaagttaac gtttcacttc acactgctaa
    98821 accaggtatg gttatcggta aaggtggtgc taacgttgat gcactccgtg caaaacttaa
    98881 caaattgact ggaaaacaag tacacatcaa catcatcgaa atcaaacaac ctgatttgga
    98941 tgctcacctt gtaggtgaag gaattgctcg tcaattggag caacgtgttg ctttccgtcg
    99001 tgcacaaaaa caagcaatcc aacgtgcaat gcgtgctgga gctaaaggaa tcaaaactca
    99061 agtatcaggt cgtttgaacg gtgcagatat cgcccgtgct gaaggatact ctgaaggaac
    99121 tgttccgctt cacacacttc gtgcagatat cgattacgct tgggaagaag cagatactac
    99181 atacggtaaa cttggtgtta aagtatggat ctaccgtggt gaagttcttc cagctcgtaa
    99241 aaacactaaa ggaggtaaat aaccaatgtt agtacctaaa cgtgttaaac accgtcgtga
    99301 gttccgtgga aaaatgcgcg gtgaagcaaa aggtggaaaa gaagtagcat tcggtgaata
    99361 cggtcttcaa gctacaacta gccactggat cactaaccgc caaatcgaag ctgctcgtat
    99421 cgccatgact cgttacatga aacgtggtgg taaagtttgg attaaaatct tcccacacaa
    99481 atcatacact gctaaagcta tcggtgtgcg tatgggatct ggtaaagggg cacctgaagg
    99541 ttgggtagca ccagttaaac gtggtaaagt gatgttcgaa atcgctggtg tatctgaaga
    99601 gattgcacgt gaagcgcttc gacttgctag ccacaaattg ccagttaaat gtaaattcgt
    99661 aaaacgtgaa gcagaataag gagaaggcat gaaacttaat gaagtaaaag aatttgttaa
    99721 agaacttcgt ggtctttctc aagaagaact cgcgaagcgc gaaaacgaat tgaaaaaaga
    99781 attgtttgaa cttcgtttcc aagctgctac tggtcaattg gaacaaacag ctcgcttgaa
    99841 agaagttaaa aaacaaatcg ctcgtatcaa aacagttcaa tctgaagcga aataatagac
    99901 tagggaagga gaaatttcaa tggaacgcaa taatcgtaaa gttcttgttg gacgtgttgt
    99961 atctgacaaa atggacaaga caatcacagt tgtagttgaa acaaaacgta accacccagt
   100021 ctatggtaaa cgtattaact actctaaaaa atacaaagct catgatgaaa acaatgttgc
   100081 caaagaaggc gatatcgtac gtatcatgga aactcgcccg ctttcagcta caaaacgttt
   100141 ccgtcttgta gaagttgttg aagaagcggt catcatctaa tcaaacctga aaggagaaaa
   100201 ctgaaatgat tcaaacagaa actcgtttga aagtcgcaga caacagcggt gctcgcgaaa
   100261 tcttgactat caaagttctt ggtggttcag gacgtaaatt tgcaaacatc ggtgatgtta
   100321 tcgtggcatc tgtaaaacaa gctactcctg gtggtgcggt taaaaaaggt gacgttgtta
   100381 aagcagttat cgttcgtact aaatcaggtg ctcgtcgtgc tgatggttca tacatcaaat
   100441 ttgacgaaaa cgcagcagtt atcatccgtg aagacaaaac tcctcgcgga acacgtatct
   100501 ttggcccagt tgcacgtgaa ttgcgtgaag gtggcttcat gaagatcgtg tcacttgctc
   100561 cagaagtact ttaattttta ggaacaaact agtcccctag cttcaagcta gggtgccctt
   100621 atgggcgtaa gaaaaatcaa ggagaaacct aatgtttgta aaaaaaggcg acaaagttcg
   100681 cgtaatcgct ggtaaagaca agggaacaga agctgttgtc cttactgccc ttccaaaagt
   100741 aaacaaagtt atcgttgaag gtgttaacat tgttaagaaa caccaacgtc caactaacga
   100801 gcttcctcaa ggtggtatca tcgagaaaga agcagctatc cacgtatcaa acgttcaagt
   100861 tttggacaaa aatggtgtag ctggtcgtgt tggatacaaa tttgtagacg gtaaaaaagt
   100921 tcgctacaac aaaaaatcag gcgaagtgct tgattaatca cgaaggaaag gagaagtata
   100981 atggcaaatc gtttaaaaga aaaatatctt aatgaagtag ttcctgcttt gacagaacaa
   101041 ttcaactact catcagtgat ggctgtgcct aaagtagata agattgtttt gaacatgggt
   101101 gttggtgaag ctgtatcaaa cgctaaaagc cttgaaaaag ctgctgaaga attggcactt
   101161 atctcaggtc aaaaaccact tatcactaaa gctaaaaaat caatcgccgg cttccgtctt
   101221 cgtgaaggtg ttgcgatcgg tgcaaaagtt acccttcgtg gtgaacgtat gtacgaattc
   101281 ttggataaat tggtatcagt ttcacttcca cgtgtacgtg acttccacgg tgtcccaaca
   101341 aaatcatttg atggacgcgg gaactacaca cttggtgtga aagaacaatt aatcttccca
   101401 gaaatcaact tcgatgacgt tgacaaaact cgtggtcttg acatcgttat cgtaacaact
   101461 gctaacactg acgaagagtc acgtgcattg cttacaggcc ttggaatgcc ttttgcaaaa
   101521 taatatagga ggtaaatcta atggctaaaa aatcaatggt agctagagag gctaaacgcc
   101581 aaaaaattgt tgaccgttat gctgaaaaac gtgctgcatt aaaggcggca ggggactacg
   101641 aaggtttatc taaattacct cgcaacgcct caccgactcg tttacataat cgttgtagag
   101701 ttacggggcg cccacattca gtttaccgca aatttggtct gagtcgtatc gcttttcgcg
   101761 aacttgcgca taaaggtcaa attcctggtg taacaaaagc atcttggtaa tttaagatat
   101821 caagggtgtc aaaactccaa gtaaaaatag gaaacttgac gaagaaacta aagtttctag
   101881 gaaagtttat ctttttcaca cagagtttag cccgggttca attgggcttg ccaatttgaa
   101941 cccgagctac agctttggca aaaaagacca atttgctttg gagcattgct tctgcattaa
   102001 attgtctatt tttgctcgtg ctgttacgct ctttgtatca tgtattaact agcaagtgca
   102061 acttgcaaac tactagtaag aggagaaaaa caaaatggtt atgactgacc caatcgcaga
   102121 cttcctaact cgtattcgta atgctaacca agctaaacac gaagtacttg aagtacctgc
   102181 atcaaacatc aaaaaaggga ttgctgaaat ccttaaacgc gaaggttttg taaaaaacgt
   102241 tgaaatcatt gaagatgaca aacaaggcgt catccgtgta tttcttaaat acggatcaaa
   102301 tggtgagaaa gttatcacta acttgaaacg tgtttctaaa ccaggacttc gtgtctacaa
   102361 aaaacgtgaa gaccttccaa aagttcttaa cggacttgga attgccatcc tttcaacttc
   102421 tgaaggtttg cttactgata aagaagcacg ccaaaagaat gttggtggtg aggttatcgc
   102481 ttacgtttgg taaaatcaag atacaaagct cgtaaagaac aaagcaaaat taggaagttg
   102541 gagaagtttg tttacaaaca agccaactta tctattttgc acagttctta gagcgtgttc
   102601 agttcagctc ttgaactaaa taagtatctg aaccccgtga aaactggccg ttctggcctg
   102661 acaatttaac aggagaaaat aaacatgtca cgtattggta ataaagttat cgtgttgcct
   102721 gctggtgttg aactcgctaa caatgacaac gttgtaactg taaaaggacc taaaggagaa
   102781 cttactcgtg agttctcaaa agatattgaa atccgtgtgg aaggtactga aataactctt
   102841 caccgtccaa acgattcaaa agaaatgaaa actatccacg gaactactcg tgcccttttg
   102901 aacaacatgg ttgttggtgt atcagaagga ttcaagaaag aacttgaaat gcgtggggtt
   102961 ggttaccgtg cacagcttca aggatctaaa cttgttttgg ctgttggtaa atctcatcca
   103021 gacgaagttg aagctccaga aggaattact tttgaacttc caaacccaac aacaatcgtt
   103081 gttagcggaa tttcaaaaga agtagttggt caaacagctg cttacgtacg tagccttcgt
   103141 tcaccagaac catataaagg taaaggtatc cgttacgttg gtgaattcgt tcgccgtaaa
   103201 gaaggtaaaa caggtaaata atgttgagtg gttgatcatc aaccaccaac ctattttcca
   103261 actttgtgca tagcacacga tttaaaacta aagaggtgaa aactgtgatt tcaaaaccag
   103321 ataaaaacaa actccgccaa aaacgccacc gtcgcgttcg cggaaaactc tctggaactg
   103381 ctgatcgccc acgtttgaac gtattccgtt ctaatacagg catctacgct caagtgattg
   103441 atgacgtagc gggtgtaacg ctcgcaagtg cttcaactct tgataaagaa gtttcaaaag
   103501 gaactaaaac tgaacaagcc gttgctgtcg gtaaactcgt tgcagaacgt gcaaacgcta
   103561 aaggtatttc agaagtggtg ttcgaccgcg gtggatatct atatcacgga cgtgtgaaag
   103621 ctttggctga tgcagctcgt gaaaacggat tgaaattcta ataggaggac actagaaaat
   103681 ggcatttaaa gacaatgcag ttgaattaga agaacgcgta gttgctgtca accgtgttac
   103741 aaaagttgtt aaaggtggac gtcgtcttcg tttcgcagct cttgttgttg ttggtgacca
   103801 caatggtcgc gtaggatttg gtactggtaa agctcaagaa gttccagaag caattcgtaa
   103861 agcagtagat gatgctaaga aaaacttgat cgaagttcct atggttggaa caacaatccc
   103921 acacgaagtt ctttcagaat tcggtggagc taaagtattg ttgaaacctg ctgtagaagg
   103981 ttctggagtt gccgctggtg gtgcagttcg tgccgttgtg gaattggcag gtgtggcaga
   104041 tattacatct aaatcacttg gttctaacac tccaatcaac attgttcgtg caactgttga
   104101 aggtttgaaa caattgaaac gcgctgaaga aattgctgcc cttcgtggta tttcagtttc
   104161 tgatttggca taagaaaggg gataaaatgg ctcaaattaa aattactttg actaagtctc
   104221 caatcggacg cattccatca caacgtaaaa ctgttgtagc acttggactt ggcaaattga
   104281 acagctctgt tattaaagaa gataacgctg ctatccgtgg tatgattaca gcagtatctc
   104341 acttagtaac agttgaagaa gtaaactaat gaagttttag gggatgtgca ctgtaccatc
   104401 ccctaaaact agatatagtc atctatgatg acatcgtata ggcgagttga tgggggagac
   104461 aaccttttct cccttatcgg cgctagcatt ttacaaaaga ggagaaaata aaaatgaaac
   104521 ttcatgaatt gaaacctgca gaaggttctc gtaaagtacg taaccgcgtt ggtcgtggta
   104581 cttcatcagg taacggtaaa acatctggtc gtggtcaaaa aggtcaaaaa gctcgtagcg
   104641 gtggcggagt tcgccttggt tttgaaggtg gacaaactcc attgttccgt cgtcttccaa
   104701 aacgtggatt cactaacatc aacgctaaag aatacgcaat tgtgaacctt gaccaattga
   104761 acgtctttga agatggtgct gaagtaactc cagttgttct tatcgaagca ggaattgtta
   104821 aagctgaaaa gtcaggtatt aaaattcttg gtaacggtga gttgactaag aaattgactg
   104881 tgaaagcagc taaattctct aaatcagctg aagaagctat cactgctaaa ggtggttcag
   104941 tagaagtcat ctaagagagg tgacctatgt tttttaaatt attaagagaa gctcttaaag
   105001 tcaagcaggt tcgatcaaaa attttattta caatttttat cgttttggtc tttcgtatcg
   105061 gaactagcat tacagttcct ggtgtgaatg ccaatagctt gaatgcttta agtggattat
   105121 ccttcttaaa catgttgagc ttggtgtcgg ggaatgccct aaaaaacttt tcgatttttg
   105181 ccctaggagt tagtccctat atcaccgctt ctattgttgt ccaactcttg caaatggata
   105241 ttttacccaa gtttgtagag tggggtaaac aaggggaagt aggtcgaaga aaattgaatc
   105301 aagctactcg ttatattgct ctagttctcg cttttgtgca atctatcggg attacagctg
   105361 gttttaatac cttggctgga gctcaattga ttaaaactgc tttaactcca caagtttttc
   105421 tgacgattgg tatcatctta acagctggta gtatgattgt cacttggttg ggtgagcaaa
   105481 ttacagataa gggatacgga aacggtgttt ccatgattat ctttgccggg attgtttcct
   105541 caattccaga gatgattcag ggcatctatg tggactactt tgtgaacgtc ccaagtagcc
   105601 gtatcacttc atctatcatt ttcgtaatca ttttgattat tactgtattg ttgattattt
   105661 actttacaac ttatgttcaa caagcagaat acaaaattcc aatccaatat actaaggttg
   105721 cacaaggtgc tccatctagc tcttaccttc cgttaaagat aaatcctgct ggagttatcc
   105781 ctgttatctt tgccagttcg attactgcag cgcctgcggc tattcttcag tttttgagtg
   105841 ccacaggtca tgattgggct tgggtaaggg tagcacaaga gatgttggca actacttctc
   105901 caactggtat tgccatgtat gctttattga ttattctctt tacattcttc tatacgtttg
   105961 tacagattaa tcctgaaaaa gcagcagaga gcctacaaaa gagtggtgcc tatatccatg
   106021 gagttcgtcc tggtaaaggt acagaagaat atatgtctaa acttcttcgt cgtcttgcaa
   106081 ctgttggttc cctcttcctt ggtgtgattt ccattttacc gattgcagct aaagatgtat
   106141 ttggtctttc tgatgttgtt gcctttggtg gaacaagtct cttgatcatt atctctacag
   106201 gtatcgaagg aatcaagcaa ttggaaggtt acctattgaa acgtaagtat gttggtttca
   106261 tggacagaac agaataaaag tatttactga atcagtaaat actgagggag tggaggttta
   106321 aactctgaca tttgtaagag ttggatctcc cctcttctat tttgttttta aataggggtg
   106381 aaaagacttt ttgcttctat ttaaaaataa aataaggaga tcaaatcatg aatcttttga
   106441 ttatgggctt acctggtgca ggtaagggaa ctcaagcagc aaaaatcgta gaacaattcc
   106501 atgttgcaca tatctcaaca ggtgatatgt tccgcgctgc aatggcaaat caaactgaaa
   106561 tgggtgttct tgctaagtca tatattgaca agggtgaatt ggttcctgac gaagttacaa
   106621 atggaatcgt aaaagaacgt ctttcacaag atgatattaa agaaacagga ttcttattgg
   106681 atggttaccc acgtacaatt gaacaagctc atgccttgga caaaacattg gctgaacttg
   106741 gcattgaact agaaggtgtt atcaatattg aagtgaaccc tgacagcctc ttggaacgtt
   106801 tgagtggccg tatcatccac cgcgtaactg gagaaacttt ccataaggtc tttaacccac
   106861 cagttgacta taaagaagaa gactactacc aacgtgaaga tgataagcct gagacagtaa
   106921 aacgtcgttt ggatgttaat attgctcaag gagaaccaat cattgctcac taccgtgcca
   106981 aaggtttggt tcatgacatc gaaggtaatc aagatatcaa tgatgtcttc tcagatattg
   107041 aaaaagtatt gacaaatttg aaataaagcg tttttcacac ttgcaaaaat ccgctacaaa
   107101 tgttatactg agatagtctg acttataatt gttgtctctg tgtctagagg catcgaatcg
   107161 aaatttatgg aggtgctttt gcgtggcaaa agacgatgtg attgaagttg aaggcaaagt
   107221 agttgataca atgccgaatg caatgtttac ggttgaactt gaaaatggac atcagatttt
   107281 agcaacagtt tctggtaaaa ttcgtaaaaa ctatattcgt attttagcgg gagatcgtgt
   107341 tactgtcgaa atgagtccat atgacttgac acgtggacgt atcacttacc gctttaaata
   107401 atcgaaaaac ttggagggat aagaaatgaa agtaagacca tcggtcaaac caatttgcga
   107461 atactgtaaa gttattcgtc gtaatggtcg tgttatggta atttgcccag caaatccaaa
   107521 acacaaacaa cgtcaaggat aagatagaaa ggagaaaaca tggctcgtat tgctggagtt
   107581 gatattccaa atgacaaacg cgtagtaatc tcattgactt atgtttatgg tatcggactt
   107641 gcaacatcta agaaaatttt ggctgctgct ggaatctcag aagatgttcg tgtacgtgat
   107701 cttacatcag atcaagaaga tgctatccgt cgtgaagtgg atgcaatcaa agttgaaggt
   107761 gaccttcgtc gtgaagtaaa cttgaacatc aaacgtttga tggaaatcgg ttcataccgt
   107821 ggtatccgtc accgtcgtgg acttcctgtc cgtggacaaa atactaaaaa taacgcccgc
   107881 actcgtaaag gtaaagctgt tgcgattgct ggtaagaaaa aataatatag gaggtaaaag
   107941 tcttggctaa accaacacgt aaacgtcgtg tgaaaaagaa tatcgaatct ggtattgctc
   108001 atattcacgc tacatttaat aacactattg ttatgattac tgatgtgcat ggtaatgcaa
   108061 ttgcttggtc atcagctggt gctcttggtt tcaaaggttc tcgtaaatct acaccattcg
   108121 ctgctcaaat ggcttctgaa gctgctgcta aatctgcaca agaacacggt cttaaatcag
   108181 ttgaagttac tgtaaaaggt ccaggttctg gtcgtgagtc agctattcgt gcgcttgctg
   108241 ccgctggtct tgaagtaaca gcaattcgtg atgtgactcc agtgccacac aatggtgctc
   108301 gtcctccaaa acgtcgccgt gtataatcat cgcattacac tgcttttcgt ttaagaggga
   108361 gtaactaaat gatcgagttt gaaaaaccaa atataacaaa aattgatgaa aataaagatt
   108421 atggcaagtt tgtaatcgaa ccacttgaac gtggctacgg tacaactctt ggtaactctc
   108481 ttcgtcgtgt acttctagct tctctaccag gagcagctgt gacatctatc aacattgatg
   108541 gtgtgttaca tgagtttgac acagttccag gtgttcgtga agacgtgatg caaatcattc
   108601 tgaacattaa gggaattgca gtgaaatcgt acgttgaaga cgaaaaaatc atcgaactgg
   108661 atgttgaagg tcctgctgaa gtaacagctg gtgacatttt gacagatagc gatattgaaa
   108721 ttgtaaatcc agatcattat ctctttacaa tcggtgaagg ttcttctcta aaagcgacta
   108781 tgactgttaa cagtggtcgt ggatatgtac ctgctgacga aaataaaaag gataatgcac
   108841 cagttggaac acttgctgta gattctattt atacaccagt tacaaaagtc aactatcaag
   108901 tggaacctgc tcgtgtaggt agcaatgatg gtttcgacaa attaaccctt gaaatcttga
   108961 caaatggaac aattattcca gaagatgctt tagggctttc agcacgtatt ttgacagaac
   109021 atcttgattt gtttacaaat cttactgaga ttgctaagtc aactgaagtg atgaaagaag
   109081 ctgatactga atctgacgac cgtattttag atcgtacgat tgaggaactg gacttgtctg
   109141 tgcgttcata caactgttta aaacgtgccg gtatcaatac tgtgcatgat ttgacagaaa
   109201 aatctgaagc agagatgatg aaagtacgaa atcttggacg caagagtttg gaagaagtga
   109261 aactcaaact cattgatttg ggtcttggat taaaagataa ataaaggagg aatacatggc
   109321 ttaccgtaaa ctaggacgca ctagctcaca acgtaaagca atgcttcgcg atttgacaac
   109381 tgaccttttg atcaacgaat caatcgtgac aactgaagct cgtgctaaag aaatccgtaa
   109441 aactgttgaa aaaatgatta ctctaggtaa acgtggtgat ttgcatgcac gtcgtcaagc
   109501 agctgcttta gtacgtaatg aaatcgcatc tgaaaactat gatgaagcaa ctgataagta
   109561 cacttctact acagcacttc aaaaattgtt ctcagaaatc gcacctcgtt atgctgaacg
   109621 taacggtgga tacactcgta tccttaaaac tgaaccacgt cgtggtgatg cagcgccaat
   109681 ggcgatcatc gaattagtat aaaatcatca attttgttga gtgttatgat gatggagtct
   109741 tgtgctctta gtctagctct ggtctaccgc taggatttcg gtcctagcgg gaacactcat
   109801 cataagttgg gatagtagac gcttgtttac gaaattgttt ttttcttaag aacaacttcg
   109861 taagcaggcg tttttgagta ttttcgttag aattatgcta tactatttga aaagaatcct
   109921 gtttaatgtt aaggtttctt attttaagaa gaattggagt ttgcttatga aagcgattat
   109981 aactgttgtt ggtaaagata aatctggaat tgttgcaggt gtttctggta aaattgcaga
   110041 attaggattg aatattgacg atatctctca aactgtcttg gatgaatatt ttacgatgat
   110101 ggctattgta tctagtgatg aaaagcaaga ttttacctat cttcgtaatg aatttgaagc
   110161 ttttgggcaa actttgaatg taaaaatcaa tattcagagt gcagcgattt tcgaagctat
   110221 gtataatatc taggaggtta tcatggatat tagacaagtt actgaaacca tcgccatgat
   110281 tgaggagcaa aatttcgata tcagaaccat taccatgggg atttctcttt tggactgtat
   110341 cgatccagat atcaatcgtg ctgcggagaa aatctatcaa aaaattacga caaaggcggc
   110401 taatttagta gctgttggtg atgaaattgc ggctgagttg ggaattccta tcgttaataa
   110461 gcgtgtatcg gtgacaccta tttctctgat tggggcagcg acagatgcga cggactacgt
   110521 ggttctggca aaagcgcttg ataaggctgc gaaagagatt ggtgtggact ttattggtgg
   110581 tttttctgcc ttagtacaaa aaggttatca aaagggagat gagattctca tcaattccat
   110641 tcctcgcgct ttggctgaga cggataaggt ctgctcgtca gtcaatatcg gctcaaccaa
   110701 gtctggtatt aatatgacgg ctgtggcaga tatgggacga attatcaagg aaacagcaaa
   110761 tctttcagat atgggagtgg ccaagttggt tgtattcgct aatgctgttg aggacaatcc
   110821 atttatggcg ggtgcctttc atggtgttgg ggaagcagat gttatcatca atgtcggagt
   110881 ttctggtcct ggtgttgtga aacgtgcttt ggaaaaagtt cgtggacaga gctttgatgt
   110941 agtagccgaa acagttaaga aaactgcctt taaaatcact cgtatcggtc aattggttgg
   111001 tcaaatggcc agtgagagac tgggtgtgga gtttggtatt gtggacttga gtttggcacc
   111061 aacccctgcg gttggagact ctgtggcacg tgtccttgag gaaatggggc tagaaacagt
   111121 tggcacgcat ggaacgacgg ctgccttggc cctcttgaac gaccaagtta aaaagggtgg
   111181 agtgatggcc tgtaaccagg tcggtggttt atctggtgcc tttatccctg tttctgagga
   111241 tgaaggaatg attgctgcag tgcaaaatgg ctctcttaat ttagaaaaac tagaagctat
   111301 gacggctatc tgttctgttg gattggatat gattgccatc ccagaagata cgcctgctga
   111361 aactattgcg gctatgattg cggatgaagc agcaatcggt gttatcaaca tgaaaacaac
   111421 agctgttcgt atcattccca aaggaaaaga aggcgatatg attgagtttg gtggtctatt
   111481 aggaactgca cccgttatga gggttaatgg ggcttcgtct gtcgacttca tctctcgcgg
   111541 tggacaaatc ccagcaccaa ttcatagttt taaaaattaa gaaaatagga gaaattttaa
   111601 gttctattta agattagatg tgtatactat aatcattaaa taaagacctc ctaatattat
   111661 ttgaaacaga taacactgaa ttagtttgaa tttgattttc atctaatatc tttatttaat
   111721 gaactcctaa actttttcat aataatctcc ttcaaaagtc gcctgtatgg gtggctttta
   111781 ttttatcatt catgatataa tagaagcaaa cggaggacgg aaaatggtaa aagtacgatt
   111841 gtatttggta cgtcatggca agaccatgtt taacacgatt ggtcgcgcgc aaggttggag
   111901 cgatactccc ttaactgctg aaggtgaacg agggattcaa gagttaggaa tcggtttgcg
   111961 agaatctgat ctacagtttg agcgcgctta ttcgagtgat tctggtcgta ccattcagac
   112021 catgggaatt atccttgaag aacttggctt gcaggggaaa atcccttatc gcatggacaa
   112081 gcgtatcaga gaatggtgtt tcggtagttt tgatggagcc tatgatggcg atcttttcat
   112141 gggcattatt cctcgtatct ttaatgtgga ccacgttcac caattgtctt atgctgaact
   112201 ggctgagggc ttggtagagg tcgatacagc tggttgggct gaaggctggg aaaaactcag
   112261 tggccgaatc aaggaaggct ttgaaatgat tgcaaaagaa atggaagatc aaggtggagg
   112321 taacgccctt gttgtcagcc atggaatgac tattggaacc attgtttatc tgattaatgg
   112381 catgcatccg catggtctag ataatggtag cgtgacgatt cttgaatatg aggacggtca
   112441 gtttagggtt gaagttgtcg gtgaccgtag ttaccgagag ctaggacgtg agaagatgga
   112501 agaaggctct atttaatcag tctagacttg cttgccatga gctagggatt tgataagaat
   112561 atcaagataa gaaaaaacag ccgagggtac tcctttcggc tgtttttgat gtggaaaact
   112621 aaagtgtaat gctattgctt ttagagattt tcataaacaa gagcaaggaa cctactgtta
   112681 gaacagtcag gatagttgac aaggctgcgg ctacaccgta atttcctctg agaacctctg
   112741 tataaatagc tacagtcatt gttcttgttt tgacattgta gaggaggata gaagtagaga
   112801 gttctgaaat cagtgtgacc caagatagga tggctccaga aataatatcc gatagcatca
   112861 ttggagttgt aatcttagca aagatattga gacgactact tcctaagctt tcagcagctt
   112921 cttcaatact tggtgctatt tgttgtaagc tagcaacaga tgagcgaata gtataaggta
   112981 attttctggc agatagagac ataatcaaga tgaaagcagt ccctgtaatc ataagaaatc
   113041 cacttccaaa tagaccagag aaatgaaggc aatccctaga acggttcctg gtacaatata
   113101 aggtaccata ctgaggctgt caattaagtt tgtaaacaaa ttccgttttc taacggctag
   113161 gtaggagata aatgtcgcaa atagaacaac tagaactaag gcaatcaaag ggatacgaat
   113221 ggtattgaaa atagcagatc ccatacgatg gaaagctacc ttgtaactgt ttggagaata
   113281 acctttaaca gataccatac ctgatgtttt taggaaagag gtataaatta agtagatttg
   113341 aggtaaaaca gagataaaga taattccgta gactgttgca taaatggcag ctatttttcc
   113401 ttttgtagtt tttttaggct caattggatg gagcagattc atgctgaaac tgtagcggtt
   113461 tgcaatgtgt ttttggataa ggaaaattgc caaggcaatg ataatcgcca taattgcaaa
   113521 agcagaattt cctccaacct cgctaataaa ttgggtataa atcaggacag ggaaagtccg
   113581 atatccttcg ccaatcaaca taggcgttcc aaagtctgag aatgctctca taaatacaag
   113641 caaggagctg ctagtaaggt tggaactagg agaggtaaaa caaccgttac gatacgctta
   113701 aatccgaagg accccatgct ttcagctgct tcaagtagag aattgtcaat actgttcatt
   113761 gttccagcaa catatagaaa taccagtggg aatagttgca gtgtaaagac aagtacaatt
   113821 cctttgaatc cataaatatc gatagctgga agatgaaggg catttgtcaa aaatttagtg
   113881 atgaccccat ttcgtcctag caagagaacc caggagtagg ctcctacgaa aggagctgac
   113941 atggaagcaa tgataatcaa tatttgtaga aatttctccc ccttgaagtc atacatagag
   114001 aagagataag ctaatagggt tcctacaact aaggaagtga cagtagcggt aatggaaacc
   114061 ttgaaactgt tgactagtgt ctcagagtag tagactttac taaagaaagt gacaaaatta
   114121 gctagtgaga attgtccttc atgtataagt gcttacttga gcacggtaac gataggataa
   114181 acgagaaaga caagataggt aagaaagatg aagaaagagg aggctgtcca aatatttagt
   114241 tttttacgtt ccatggttga ctccttttat caggttttgg gaaccatctg cagaaaagat
   114301 gtttaatttt tgcgtattga ttcgtagacg aatacgattg cctttttgta gatcttcttc
   114361 aaaagttgat tcttcactaa cttgaatttt tgaggcaaaa cctgtctcaa tgaaatactc
   114421 cgtatttagt ccaagataga cgctatcgct aatagttcct tcaatatctc cagattcatc
   114481 tttgataaac tcttcgggac gaatgcttac atgaatagct tgctcctcaa cctgatcaag
   114541 aactggcatt cgaagggcat agccatctga aaagacgata taagcgccgt cgctccgttt
   114601 ttcaagatta gtagggataa tatttgtgcg tccgataaag gttgccacaa actcattagc
   114661 tggtttatga tagagttctt ttggtcggcc gatttgttgg atcaccccat ctttcataac
   114721 agcaatttgg tctgaaatag ccatggcttc ttcttggtcg tgggttacat aaacagttgt
   114781 aattcccact tcgtgttgga tttctcggat ggcttgacgc atatccaagc gaagtttggc
   114841 ctccagatta ctaagtggct cgtccatgag gagaacactt ggattaaccg ctaaggcgca
   114901 tgccaaggtg acacgttgtt gttgtccacc actgagttta tcgggctttc gatccgcata
   114961 ttgagcaatt tgcatgagtt caagatactt gttggtctgt tgaatcaatt cttcttttgg
   115021 aaccttcttt tgcataagac caaaagcaac gttgtctcgg acagtcaaat gtgggaaaat
   115081 agcgtagttt tggaaaacca gcccgatatt gcgtttgctg ggttccatat tattgatttt
   115141 tgtatcatcg aagtaaaatt ctccatcttt gatactgttg aaacctgcaa tcatacgaag
   115201 aagggtcgtt ttcccacatc ctgaagctcc aagaagggta aagagacttc cttttggaat
   115261 tgtaatgttc aaattctcaa taacagggac atcgtggtag atttttttgg cgttaataat
   115321 ttcgatctca ctcatagtga acctctttta ctgtttagat tggatatctg taaagacttc
   115381 gttgtatttc ttaacgatat ctgatttatt cttgatgaca taatcataat cttcagtgag
   115441 tgttttgatt ttgtcaattg gtttcatgtt ttcgcttgtt ttagcatttt tacgaacagg
   115501 acggttagta gtggttgtac caagtgtatc ttgtacttct tgagagataa taaaatcgat
   115561 aaatttcttg gcattttcca tatttttagc ttttttaacg atagcagcac tagcaggtag
   115621 gaagacggtt ccttcttttg gatagactac tttaatgtta gctccgtcat ttaagagttt
   115681 aactgctgga tcctcataag agagaccaac agccatttct ccatcaacga ctgctttata
   115741 gacaccagat gaacttgaac cgattttata gtgtattgaa actagaatag tacacctcta
   115801 cttctaaaac attgttagaa atcgatttga ctgtcctgat taatttgtcc tgttcttatt
   115861 tcattttact ataccatcaa taagtgtgaa aagatctttt acataagacc aagccttatc
   115921 atctttgtaa ccaccttgag cttgtagcat atttgttaat tgagcaaagg cgctagaaga
   115981 gtttgctggg tcagcagttg cgatttttcc ttttagttca ggtttgagaa ggtcgctata
   116041 tccttcgatg ttcatgcctt tagttaaatc agggtggacg attaaaacac taccatctag
   116101 tgtataagga gtagagaagc cagttgtgtt ttgatattct ttgataacat tatcattttc
   116161 ttttgaaata tagttttcaa agagttctcc gtgggtagca tattgtgtat aagaaccacc
   116221 aaagataaca tcagctacag gaacttcttt ttctgactct agttttttga aaagttctcc
   116281 agtaccagct tgaatcagtt ctattttgat accatatttt tcttcaaagg caggaatagt
   116341 tgctccaatt aagccttctg agtttggtga ataaacgact agcgaaccac cgtctccttt
   116401 atcagatgaa ctgtcatcgg cagattcatt agaagaacaa gcagcataat acatccattt
   116461 ctttttcatg atggatacct ccgttgtgtt atttaagttt attttaaaac aatgtaagcg
   116521 tttttaaaac ctacaattct attctatagt gtattgaatc tataacagta cactttgact
   116581 gctaaaatat ttctataaat taatttgact ttcctgatag agatgttcac atcttatttc
   116641 aattcactat attagagtaa aattctctac aaaaagaaga acagcctatt tgactattct
   116701 tccgagtgat ttcaatttct ttggggaaat atggagatac tttttaaata ctttggcaaa
   116761 atatttatag tctgaaaatc caacttggtc agagatagcg cttaaagggg agttgggaga
   116821 ttcagccatc ttatctatag cttgtttcag gcgatattgt aagatatatt catttagagt
   116881 catggggaag tcttctttga taaccttata tagatgcttg ttatctgcaa atagctagag
   116941 catttcaagg aaatgaacta gaaataacaa ttaatatggt ggttcagaaa taccttttga
   117001 taatcaataa gatcttcagg atgaagtgcg ttgactccat ccatttcata tttccgattt
   117061 aataaacgat atttgttttc accaaattga tgaaaaggga gtagttgaac ttggtcgata
   117121 tttaatgagt taaatagagt agcgaatttt tctgcatcct ctaaactatt gttaaaatta
   117181 ggaataactg ggattcttaa aacgatagtt ttattttgag aaaaagcata atgaatgttt
   117241 ttaataatca tttgattaaa aaccccagtc acttttttat gttttataga attataatgt
   117301 tttaggtctg tgtagataaa atccacatat tgaattaaat cgataaattt ttcatgatca
   117361 acaaaggcag tagtttcaat ggcagtgtgt atgtgatgtt ctttagctga ttttaagatg
   117421 gctttagcaa attcaaactg agcaaatatt tcacctcctg ataaagttaa acctccaccg
   117481 gattcttcgt aaaattcttt gtcttttaat acctctgtaa taatttcttc tacagtcttt
   117541 tcttcaccga ctaaggtgaa tttctctcgt tgagcatctt tcattttttc aggtttcatt
   117601 ctttgagatt caggattaga acaccatgga cagcgcagag gacatccttt taaaaaaaca
   117661 gttgtacgaa tacccgggcc gtcatgaatt gaaaagtgtt gaatattaaa aataattcct
   117721 ttagatattt ccataagagt tcctcctctt cataagtcta tcctatcaca aaaacgaaag
   117781 aaaaacaatt acgaacgaaa ggttaatttg ttgttttttg ctttttattt tggtagaata
   117841 aaacggaggt gtaaaatgaa aagattggaa caaattatta aattagtatc agaatatgaa
   117901 aagatcgacg ttaatacatt atcggaaaaa ttaaatgtat cgaaagtaac gattagaaaa
   117961 gatttagata aattagagtc aaaaggttta ttacacagag agcatggata tgctgtatta
   118021 aatagtggag atgacttaaa tgtacgtttg tcaattaact atgaaattaa gagaaaaatt
   118081 gttcaggaag cagtaaaatt ggtgtcagat aatgaaacaa taatgataga atctggatcg
   118141 acctgtgctt tacttgctga ggaaatttgc aagcaaaaaa gaaatgttac gattgtaaca
   118201 aattcatttt ttatagcaaa ttttgtgaga gcttatgatt catgtcgtat tattgttctt
   118261 ggtggagagt ttcagaagga ttcacaggtt actgtgggac ctttattaaa agaaatgata
   118321 cagacttttc atgtgcatca agcttttgtt gggacagatg gttacgataa agagatgggc
   118381 tttacaggaa aagatttaat gcgcagtgag gtagttcaat atatttcagc agcgtcggat
   118441 aaagtcattg tactaactga ctcaagtaaa tttgataaaa ggggtacagt aagaagattt
   118501 gctttaagtc aagtctatga agtaataaca gacgaaaaac tttctaaaca aaatatagct
   118561 acattagaaa atgctgggat aatggttaag gtagtttcgt aagaggttaa gtgtatgaat
   118621 caagatagga ataaactgct ttctaaaatt gcttatctgt attatattga aaacttaaat
   118681 cagtcacaaa tagcagcaaa attaggaatt tatagaacct ctattagtag aatgctaaca
   118741 gaagcaagga atgtaggaat tgttaaaatt gaaatagaga attttgatac caatatgttt
   118801 aagttggaaa attatgtaaa agaaaaatac agtttggaaa gtttagaaat tattccaaat
   118861 gaatttgatg atactccaac aattttatct gaaagaattt ctcaagttgc agcaggcgtc
   118921 cttaggaatc taattgatga taatatgaaa attggctttt cttgggggaa aagtttaagt
   118981 aatttagtag atttaattca cagtaaaagt gtccgaaatg ttcacttcta tcctctagca
   119041 ggtggtccta gtcacataca cgctaaatac catgtgaata cactgattta tgaaatgtct
   119101 agaaaatttc atggagagtg tacatttatg aatgcaacga ttgtgcaaga aaataaattg
   119161 ttagcagatg gtattttgca atcaagatat tttgaaaatt tgaaaaatag ttggaaagat
   119221 ttagatatag ctgtagtcgg aattggtgat tttagcaata aagggaaaca tcaatggtta
   119281 gacatgctta cagaggatga ctttaaagaa ttgaccaaag ttaaaactgt aggagaaatt
   119341 tgttgtcgat tttttgattc aaaaggtaaa gaagtctatg aaaacttaca ggaaagaacg
   119401 atagccatct ctttggaaga tttaaaaaat attcctcaaa gtttagctgt tgcttacggt
   119461 gatacgaaag tatcttcgat tctttctgtc ttgcgtgcta atttagtaaa tcatttgatt
   119521 acagataaaa atacaatttt aaaagttttg gaagaagatg gtgatttgac ttttagagag
   119581 attctaggtg agtgaaaatg atagactgat cagtttatcg ttttttcttt ttagtcgatt
   119641 gcacatttgt gcttatataa acaaaaatag tttatctgtt gtttttggat tgacaacttt
   119701 attatgtagt tgtattctat agttacaaaa gaaaatttta aaatttcaaa tgaaaaaagc
   119761 tttttacata gtgaaatgag gaggaattta tggaaattat tgttccagat caaattatca
   119821 tgggtttaat tttatatgct ggcgatgcga aacaacatat ttataaagca ttagattaca
   119881 taaagaacgg tacatgtgaa cgatgtgaag aagaaatcca gttagctgat gccgccttat
   119941 tagaagctca taatctacaa acaaaattct tggcacagga agcgtctggt acaaagacag
   120001 aaattacagc tctctttgtt cattcacaag atcatctcat gactagtatg acggagatta
   120061 atttaatcaa agaaattatt agtttgagaa aagaacttca taaaaaataa tactagagta
   120121 ttatcattgt tattaacata gaggaggaaa acataatggt gaagattggt ttgttttgtg
   120181 cagcaggttt ttctactggt atgcttgtaa ataatatgaa aattgcagcg caagctagtg
   120241 gagttgaggc agaaatagag gcgttttctc agtctaaatt agcggattat gcgccaaata
   120301 tagatgttgc actattgggt ccacaagttg cttatacatt agataaatca aaagaaattt
   120361 gtgataagtg tgatgttccg atagctgtta ttccgatgat ggactatggt atgttagatg
   120421 ggaaaaaagt attagatttg gccctatctt tgattagtgg gtaagaaaag gagatttatt
   120481 atgtcaaaga tggatgttca gaaaatcatt gcaccgatga tgaagtttgt gaatatgcgt
   120541 ggcattatag ctctaaaaga tgggatgtta gcaattttgc cattgacagt agttggcagt
   120601 ttgttcttga ttatgggaca attgccgttc gaaggattaa ataagagcat tgctagtgtt
   120661 tttggagcta attggacaga gccgtttatg caagtatatt caggaacttt tgctattatg
   120721 ggtctaattt cttgtttttc aattgcctat tcttatgcta agaatagcgg agtagaggct
   120781 ttaccagctg gagttctatc tgtatctgca ttctttattt tgctaagatc atcttatatc
   120841 cctaaacaag gtgaggcgat tggggacgct attagtaaag tttggtttgg aggccaagga
   120901 attatcggtg ctatcattat aggtttggta gtaggaagta tttatacctt ctttataaag
   120961 agaaaaattg ttattaagat gccagaacaa gttccacaag ctattgccaa acagtttgaa
   121021 gcaatgattc cagcatttgt aattttctta tcttctatga ttgtatatat tttagcgaag
   121081 tcaatgacta atggcggaac attcatagaa atgatttatt ctgctattca agttccgttg
   121141 caaggtttaa ctggatcttt gtatggtgct attggaattg cattctttat atcatttttg
   121201 tggtggtttg gtgttcatgg gcaatcggta gtaaatggag tagtgacagc tctgctttta
   121261 tctaatcttg atgctaataa agctatgtta gcctctggta atctatcatt agaaaatgga
   121321 gcacatattg ttactcaaca gtttttagat tcatttttaa ttctatcagg ttcagggatt
   121381 acgtttggtc ttgtagttgc catgcttttt gtagcaaaat caaaacaata ccaagcctta
   121441 ggaaaagttg cagcttttcc agcaatattt aacgtaaatg agccagttgt atttggattt
   121501 ccgattgtca tgaatccagt tatgtttgta cctttcattc ttgttcctgt acttgcagct
   121561 gtgatagtat atggagctat tgcaacaggt ttcatgcagc cattctcagg ggtaacattg
   121621 ccttggagta caccagctat tctatcagga tttttggtgg gtggatggca aggtgttgtg
   121681 actcagttat tagtattggc gatgtctaca atggtttact ttccattctt taagatacag
   121741 gatcgtttag cttaccaaaa tgaaatcaaa caatcttaga ggtatttgtg tgttactgtt
   121801 aaactcacac atttgtgcta aaaattagag agttaaaatt tttctagtta aaagcttgaa
   121861 aatttctata aaaatcggta ttatattttc gaaagaaata aaaatatttt cgaaagaaag
   121921 gtgcttacga tggtaaatac agaagtagca agaacaacaa tcaagacaga atattttggc
   121981 agccttactg aaaggatgaa caaatatcga gaagatgttt taaataaaaa accttatatt
   122041 gatgctgaga gagcagttct agcaacacgc gcctatgaac gatacaagga acaacctaat
   122101 gtcctaaaac gtgcatatat gctgaaagaa attttggaaa atatgactat ctatattgaa
   122161 gaagaatcta tgattgcggg aaatcaagct tcttccaata aagatgctcc tatttttccg
   122221 gaatatacgc tagaatttgt tctcaatgag ttggatcttt ttgaaaagcg tgatggagat
   122281 gttttctata ttacagaaga aacaaaagaa caacttagaa gtattgctcc gttttgggaa
   122341 aataataatt tacgtgctag agctggtgcc ttattacctg aagaagtgtc tgtttatatg
   122401 gaaacaggat tcttcggtat ggaaggtaag atgaattctg gagatgctca cttagcagtt
   122461 aactatcaga aactgttgca atttggttta agaggttttg aagagcgggc tcgtaaagca
   122521 aaagtagctc tagatttaac agatccagca agtattgata aatatcattt ttacgactct
   122581 atatttatcg taatcgatgc tattaaagta tatgcaaagc gctttgttgc tcttgctaaa
   122641 agtttagccg aaaatgcaaa tcctaaacgt aagaaagaat tacttgagat tgcagatatt
   122701 tgctctagag tcccatatga accggcaact acttttgcag aagctattca atcagtttgg
   122761 tttattcaat gtattttaca aattgaatct aatggccact ctctttcata tggccgtttt
   122821 gatcaatata tgtatccata tatgaaggct gatttagaaa gtggtaaaga aacagaagat
   122881 agcattgttg aacgtctgac aaatctttgg attaagacaa ttacaattaa taaggttcgc
   122941 agtcaatcac atacattttc ttcagcagga agtcctttat atcaaaatgt tacaattggt
   123001 ggacagactc gagataagaa ggatgctgtt aacccattat cttatttggt attaaaatca
   123061 gttgcacaaa cccatctacc gcaacctaat ctaactgtac gttaccatgc aggtttagat
   123121 gctcgtttca tgaatgagtg tattgaagtg atgaaacttg gttttggtat gcctgcattt
   123181 aataatgatg agattattat tccttctttt attgcaaaag gagtattgga agatgatgct
   123241 tatgattaca gtgccattgg atgtgttgaa acggcagttc cagggaaatg gggctatcgt
   123301 tgcacaggta tgagttatat gaacttccct aaggttctac ttatcacgat gaatgatgga
   123361 attgatccgg cttcgggtaa acggtttgca ccaagctttg gtcattttaa ggatatgaag
   123421 aacttttctg aattagaaaa tgcttgggat aaaacactaa gatatttgac acgaatgagt
   123481 gttattgttg aaaattctat tgatttatca ttggaacgag aagttcctga tattctatgt
   123541 tcagcattga ctgatgattg tattggtcgt ggaaaacacc ttaaagaagg tggagcagta
   123601 tatgattata tatcaggatt gcaagttgga attgcaaatt tgtcggattc attagctgca
   123661 attaaaaaat tggtgtttga ggaagaacgt ataagcccaa gtcagctttg gcatgcattg
   123721 gaaacagatt atgccggaga agaaggtaag gtcattcaag aaatgttgat tcatgatgca
   123781 cctaagtatg gtaatgatga tgattatgct gacaaattgg ttactgctgc ttatgacatt
   123841 tatgttgatg aaattgctaa atatcctaat acacgttatg gaagagggcc tattggagga
   123901 attcgttatt caggaacatc ttctatatca gccaacgtag ggcagggacg tggaacatta
   123961 gcaactccag atggacgcaa cgcgggtaca ccgttagcag agggttgttc accatcacat
   124021 aatatggatc aacacggccc tacatctgtt ttaaaatctg tttcaaaatt accaacagat
   124081 gaaatcgtag gtggggttct cttaaatcag aaagtaaatc ctcaaacgtt agccaaagaa
   124141 gaagataaat taaaactaat tgctttgtta cgaacattct ttaatcgttt acatgggtac
   124201 catattcaat acaatgttgt ttccagagag acgttgattg acgctcagaa acatcctgaa
   124261 aaacacagag acttaattgt tcgtgttgca ggatactctg cattcttcaa tgttctttct
   124321 aaggcaactc aagatgacat tataggacgt actgagcata cattgtaaaa taaagaggtt
   124381 ctttttatgg aatttatgct tgacacatta aatttagatg agattaaaaa gtggtctgaa
   124441 attttgccgc tagctggggt aacttcaaat cccactattg caaaaagaga gggttctatt
   124501 aatttttttg aacgaatcaa agatgtaaga gaattgattg gctctacacc ctctattcat
   124561 gttcaggtga tttctcaaga ttttgaaggc atcttaaagg atgctcatga aattcgaaga
   124621 caagcaggag atgatatatt tatcaaagta cctgttactc cagctggatt acgtgcaata
   124681 aaggtgctaa aaaaagaggg ctaccatatc actgcaacag ctatttatac agttattcag
   124741 ggattattag ctatcgaagt aggagcggat tacctagctc catattataa tagaatggaa
   124801 aatctgaaca ttgattcaaa ttctgtcatt cgtcaattag ctcttgctgt tgatagacag
   124861 aactctccta gtaagatttt agctgcatcc tttaaaaatg tagcacaagt aaataatgct
   124921 ttagctgcag gtgcgcatgc tgttacagca ggagcagatg tttttgaatc agctttcgcc
   124981 atgccatcta tccaaaaggc ggttgatgat ttttctgacg attggtttgt tattcaaaat
   125041 agtcgttcca tttagataga gaggaaatac atatgagaat ttttgctagt ccttctagat
   125101 atattcaggg ggaaaatgcc ttgtttgaaa atgccaaatc aattttggat ttgggaaatt
   125161 acccgattct attatgcgat cagttggttt atgatattgt tggaaaacga tttgaagatt
   125221 acctacatag gtatggtttc catattgttc tggcgctatt taatggtgaa gcttctgaca
   125281 atgaaatcaa tcgagttgtt gccttggctg agaaagaaaa ttgtgatagt attatcggtc
   125341 ttggtggggg aaagacgatt gatagcgcaa aagctattgc agatttgatt gaaaagcctg
   125401 ttattattgc tccaacaatt gcatcgaccg acgcacctgt atctgcttta tctgttattt
   125461 atacagatga aggtgcattt gatcattatc tattttattc taaaaatcca gatttagttt
   125521 tggttgatac aaaagttatt tcacaagccc ctaagcgttt attagcgtct ggtattgcag
   125581 atggtttagc aacttgggtt gaggcgcgtg cggttatgca ggcaaatgga aaaactatgt
   125641 tgggacaaca gcaaacattg gctggagttg caattgcgaa gaaatgtgaa gaaacgctgt
   125701 ttgcagatgg tttacaggct atggcagctt gtgaagctaa agtggtgaca ccagcattag
   125761 aaaatattgt tgaagctaat actttattga gtggtctagg ttttgaaagt ggaggattag
   125821 ctgcggcgca tgcaattcat aatggtttta ctgcattgac aggtgacatt catcatttaa
   125881 cacatggtga aaaagtagct tatggaactt tagtacaact attattggaa aatagaccta
   125941 aagaagaact tgataagtat attgagtttt acaaaaaaat tggtatgcca acaactctaa
   126001 aagaaatgca tttggatcaa gttggatatg atgatttaat aaaagttggt aaacaagcaa
   126061 ctatggaggg tgagacaatt catcagatgc cgtttaagat ttcgccttca gatgttgctc
   126121 aagctattat cgctgtagat gcctatgtaa attcaaaata aacaataagg actactgttt
   126181 tccaaatggt agtcttttat tgatccctgt attgaattct atagaagatt gaaataggat
   126241 gagaacaaat cgattgggaa agtaaaatta atttctataa atgttttagc aattgtttcg
   126301 tactatttca gattcagtct actatacgtt cttcataaat caaaaagcga cataggtagt
   126361 cggctattta ttgtgaatac attaattagc attccagttt tatcttcggt ctaaaataag
   126421 tattttgtgc tatacgagat aagcttcttg acttactcct tgatttactg cataacaatg
   126481 ggataaaaag tgggagatag agcaattcat agtcatcaaa attaatgaga tacagtatac
   126541 agtttttcct ttaaacacat ttcaaattcc ctcaaaaatg gtataatagt aacatcacaa
   126601 aattggagag agaccatgag tttttacaat cataaagaaa ttgagcctaa gtggcagggc
   126661 tactgggcag aacatcatac atttaagaca ggaacagatg catcaaaacc taagttttat
   126721 gcgcttgata tgttccctta tccgtctgga gctggtctgc acgtaggaca cccagaaggt
   126781 tatactgcaa ccgatatcct cagtcgttac aaacgtgcgc aaggctacaa tgtccttcac
   126841 ccaatgggtt gggatgcttt tggtttgcct gcagagcaat acgctatgga tactggtaat
   126901 gacccagcag aatttacagc ggaaaacatt gccaacttca aacgtcagat caatgcgctt
   126961 ggattttctt atgactggga tcgtgaagtc aacacaacag atccaaacta ctacaagtgg
   127021 actcaatgga ttttcaccaa gctttacgaa aaaggcttgg cctatgaagc tgaagtgcca
   127081 gtaaactggg ttgaggaatt gggaactgcc attgccaatg aagaagtgct tcctgacgga
   127141 acttctgagc gtggaggcta tccagttgtc cgcaaaccaa tgcgccaatg gatgctcaaa
   127201 atcacggctt acgcagagcg cttactcaat gacttagatg aacttgattg gccagagtct
   127261 atcaaggaca tgcaacgcaa ctggattggt aaatcaactg gtgctaatgt aacctttaaa
   127321 gttaagggaa cggacaagga attcacagtc tttaccactc gtcctgatac tcttttcggt
   127381 gcgactttca ctgtcttggc tcctgaacat gaattagtag acgctatcac aagttcagag
   127441 caagcagagg ctgtagcaaa ctataaacat caagctagcc tcaaatctga cttggctcgt
   127501 acagaccttg ccaaagaaaa aactggtgtt tggactggtg cttatgccat caaccctgtc
   127561 aatggtaagg aaattccaat ctggattgcc gactatgttc ttgctagtta cggaacaggt
   127621 gccgttatgg ccgttccagc tcacgaccaa cgtgactggg aatttgccaa acaatttgac
   127681 cttccaatcg tcgaagtgct tgaaggtgga aatgtagcag aagctgccta tacagaggat
   127741 ggtcttcatg tcaattcaga cttcctagat ggactcaaca aagaagaagc tattgccaag
   127801 attgtggctt ggttggaaga aaaaggctgt ggacaagaga aggttaccta ccgtctccgc
   127861 gactggctct ttagccgtca acgttactgg ggtgaaccaa ttcctatcat tcattgggaa
   127921 gatgggactt caacagctgt tcctgaaagt gaattgccac ttgtcttgcc tgtaaccaag
   127981 gatatccgcc cttcaggtac aggggaaagt ccattggcta acttgacaga ttggcttgaa
   128041 gtgactcgtg cagatggtgt caaaggtcgt cgtgaaacca acactatgcc acaatgggca
   128101 ggttcaagct ggtactacct ccgctatatt gacccgcaca atactgagaa attggctgat
   128161 gaggacctcc tcaaacaatg gttgccagta gatatctacg tgggtggtgc ggaacatgct
   128221 gtacttcact tgctttatgc tcgtttctgg cataaattcc tctatgacct cggtgttgtt
   128281 ccgactaagg aaccattcca aaaactcttt aaccaaggga tgattttggg aacaagctac
   128341 cgtgaccacc gtggtgctct tgtgacaacc gacaaggttg aaaaacgtga tggttccttc
   128401 ttccatgtag aaacagggga agagttggag caagcgccag ccaagatgtc taaatcgctc
   128461 aagaacgttg ttaacccaga cgatgtggtg gaacaatacg gtgccgatac ccttcgtgtt
   128521 tatgaaatgt ttatgggacc actcgatgct tcgattgctt ggtcagaaga aggtttggaa
   128581 ggaagccgta agttccttga ccgagtttac cgtttgatta caagtaaaga aatccttgcg
   128641 gaaaacaatg gtgctcttga caaggcttac aacgaaacag tcaaagctgt tactgagcaa
   128701 attgagtctc tcaaattcaa cacagctatt gcccaactta tggtctttgt caatgctgct
   128761 aacaaggaag ataagcttta tgttgactat gccaaaggct ttattcaatt gattgcacca
   128821 tttgcacctc acttggcaga agaactctgg caaacagtcg cagaaacagg tgagtcaatc
   128881 tcttatgtag cttggccaac ttgggacgaa agtaaactgg ttgaagacga aatcgaaatc
   128941 gttgtccaaa tcaaaggtaa agtccgtgcc aaactcatgg tcgctaaaga cctatcacgt
   129001 gaagaattgc aagaaattgc tctagcggat gaaaaagtca aagcagaaat tgacggtaag
   129061 gaaatcgtga aagtgattag tgtaccaaat aaattggtta atattgttgt aaaataacca
   129121 atttatttgc tgatttccaa cctcaaacag tttcccaaac tgtttgagcc aactaaactc
   129181 gttaatatcg ttgtgaaata aggtaggaat ccttcagagt agaatctgga ggattttttg
   129241 aatcttctta tgaaagtatg gtatactatg ggcaactata aagtttgaaa agtgaaaaaa
   129301 ggagaaagct atgccagtaa atgaatatgg tcaaatgatt ggggagtcaa tggaaggtta
   129361 tacaccaggt gaactgcctt ctattgattt cttagaaggg cgttatgcta ggatagaggc
   129421 tctttcagtg gaaaagcatg cggaggattt gctagctgtt tatgggcctg atacgcctca
   129481 ggagatgtgg acctaccttt ttcaggagcc agtagcagat atgggggagc tggttagcct
   129541 tttacatcag atgttggctc gtaaggaccg tttttactat gcaatcatag acaaggcgac
   129601 tggtaaggct ttgggatctt tttctctcat gcgcattgac cagaataacc gagtaataga
   129661 agtcggagca gtcacttttt ctccagagct aaggggtaca cggataggaa ctgaagctca
   129721 gtatctccta gctcgctatg tttttgagga gctaaactat cgtcgctacg agtggaaatg
   129781 cgatgcctta aatctgccat ccagacgagc tgcggagcgt ttgagcttta tttatgaagg
   129841 aaccttccgt caggcagtgg tttataaggg acgtacgaga gatacggatt ggttgtctat
   129901 gattgataag gactggcctc aagtcaaaga tcgtttggaa acatggttgc gtcctgaaaa
   129961 ttttgataaa aatggacagc agtacaagag cttgagagaa ctttaagagg tgttgagatg
   130021 attactatta aaaagcaaga aattgtcaag ctagaggatg ttttgcatct ctatcaggct
   130081 gtcggttgga caaactatac ccatcaaaca gagatgctgg agcaggcctt atctcattca
   130141 ttagtaattt atctggcact tgatggtgat gctgtggtgg gcttgattcg tttggttgga
   130201 gatggttttt catcagtttt tgtacaggat ttgattgttt tgtctagcta tcagcgccaa
   130261 gggattggta gctccttgat gaaacaggct ttaggaaatt ttaaagaggc ctatcaagtc
   130321 cagctggcga cagaacagac agaaaaaaac gtgggattta atcgttctat gggctttgaa
   130381 attttatcca cctataattg gatagggatg acttggatga atcgtaaaaa ataacaaaac
   130441 ttgttttttc ttaagcaaaa tttaaggatg gtctagtatt atataatcat taaataaaga
   130501 cctcctaact ttatttaata aaatcctaaa cttttttcat cacaatctcc taatgaagcc
   130561 acccaatcag gtggcttttt tgcgtggtga ggtgctggtg atagaaattt tttgcaaaat
   130621 ggtaaaattt tagaaaagtt aagctagttt taagtttcgt cttgtatcat gtagttatta
   130681 aataaagacc tcctaacttt atttaataaa atcctaaact tttctttttc ataataatct
   130741 cccttaactc cacccaatca ggtggagttt tttagctcta tttcaggctt ttggggacta
   130801 ttctaaaaat aatttttcga tatttttcgg tatttttcgg attttggtcg gggaattggc
   130861 ggggactttt ttagcgaata tgactaagaa ataggtctgt ggtcgcttca gctagttcaa
   130921 actcaatttg attgtaagtg actgttaatt gaaggactgg aactactgta ataatgattt
   130981 tgcttgtcta gtagtggcgt attaaatgag aagtgacatg taagattgtc tcttcgttta
   131041 cgaaatcaaa atttctatga aattgataga atccctaacg ttctcttaat cttaaccgtc
   131101 ttgtcgtaca gcggttgaag aaaatgtaaa cctttgacaa aattcgtgaa ctatgggata
   131161 ataaaaagga attgagtact agttctatat cataggctag aaaagacccc aagctcacga
   131221 ccaaataagc ttgaggtctt ttttgacact atttgtcctt gtttagccat ttatcgacta
   131281 tacgaagaac gacaccgacc acaattggtc cgatgatagt tttgagtact aattccatca
   131341 tgggctatct cacctccttt cgtaggcggt gtagaagtgc cgtataatat tataccacat
   131401 aagtgctaaa cttaggagtc acccaatcag gtggcttttt tgtttgtggc ttgttttttt
   131461 gatataatag agccatgagt agaattttag ataatgagat gatgggtgat gaggagttag
   131521 tagaacgcac gctccgtcct cagtatttac gtgaatatat tggtcaggat aaggttaagg
   131581 atcagcttca gatctttatc gaagccgcta aaatgcggga tgaagcgctg gatcatgtgc
   131641 tcttatttgg ccctccaggg cttgggaaaa caaccatggc ttttgtcatt gccaatgaac
   131701 tgggagtcaa tctcaagcaa acgtctggtc ctgttatcga aaaagcgggt gatttggtag
   131761 cgattttgaa tgagttagag cctggagatg tcctctttat tgacgagatt catcgcttac
   131821 ccatgtcagt ggaagaagtg ctttatagtg ccatggagga cttctacatc gatattatga
   131881 ttggggctgg tgaaggcagt cgcagtgttc atttggagtt gcctcctttt accttgattg
   131941 gtgcgacgac tcgggctggt atgctctcaa atccactacg ggcacgtttt gggattacag
   132001 gtcatatgga gtattatgcc catgctgact tgacagaaat tgtcgagcgg acggcagata
   132061 tttttgagat ggaaatcact catgaggcag catctgagtt ggccctacgt agtcgtggaa
   132121 cccctcgtat tgccaatcgt ctcctcaagc gcgtgcgcga ttttgcccag ataatgggga
   132181 atggggtaat cgatgatatt attaccgata aggctttgac tatgctggat gttgaccatg
   132241 aaggtttgga ctatgtggat caaaaaatcc ttcgtaccat gattgagatg tacagtggag
   132301 gacctgttgg tctaggaact ctttctgtga atatcgccga agagcgtgag acagttgaag
   132361 atatgtatga gccttacttg attcaaaaag gttttatcat gcggacacgg tctggacggg
   132421 tggcgactgc taaggcatat gagcacttag gttatgaata cagtgaaaaa taagcaagaa
   132481 atcttagagg cttttagaga aaatccagat atgatggcca ttctgacgat catccgagac
   132541 cttggtctga aagactcgtg gttggcagca ggttctgtca gaaatttcat ctggaatctc
   132601 ttgtcagaca aatcaccttt tgactttgaa acagatgtag atgtgatttt ctttgatccg
   132661 gatatttctt atgaggaaac cttattactg gagaaaaagc tgagagagga ttttcctcag
   132721 taccagtggg aattgaaaaa tcaggtctat atgcatcagc acagtcctca cactgctttc
   132781 tataccagtt ctcgtgatgc tatgagtaag tatccagaac ggtgtacggc agttggactg
   132841 cgcttgaatg aagaatcaga ttttgaactc tatgtacctt atggtttgga ggatattttg
   132901 aattttcaag ttcgtccaac tcctcatttc ttagaaaatg aagaccgaat ggaactctat
   132961 caaacacgtt tattcaagaa aaattggcag gagaaatgga aaaatttgat ttttaaaaat
   133021 acttaaggaa actttaagct agggagtgta cactaagttc ataagttaag aaaaccttaa
   133081 cttaaactcc taaaactttt tcataataat ctccctataa aaataaagtc gcccaatcag
   133141 gcggcttatt tttttgaaaa atgggcttgg tgcctgagaa taaatagctt agtgatagaa
   133201 gaaaatgggg aaatatggta taatgaaacg atagattttt gaataggaat aagatcatgt
   133261 ttggattttt taagaaagat aaggctgtgg aagtagaggt tccgacacag gttcctgctc
   133321 atatcggcat catcatggat ggcaatggcc gttgggctaa aaaacgtatg caaccgcgag
   133381 tttttggaca taaggcgggc atggaagcat tgcaaaccgt gaccaaggca gccaacaaac
   133441 tgggcgtcaa ggttattacg gtctatgctt tttctacgga aaactggacc cgtccagatc
   133501 aggaagtcaa gtttatcatg aacttgccag tagagtttta tgataattat gtcccggaac
   133561 tacatgcgaa taatgttaag attcaaatga ttggggagac agaccgcctg cctaagcaaa
   133621 cctttgaagc tttaatcaag gctgaggaat tgactaagaa caacacagga ttgattctta
   133681 attttgctct taactatggt ggacgtgctg agattacaca ggcgcttaag ttgatttccc
   133741 aggatgtttt agatgccaaa atcaacccag gtgacatcac agaggaattg attggcaact
   133801 atctctttac ccagcatttg cctaaggact tacgagaccc agacttgatt atccgtacta
   133861 gtggagaatt gcgtttgagc aatttccttc catggcaggg agcctatagt gagctttatt
   133921 ttacggacac cttatggcct gattttgacg aagcagcctt gcaggaagct attcttgcct
   133981 ataatcgtcg ccatcgccga tttggaggag tttaggagga aatatgaccc aggatttaca
   134041 gaaaagaacc ttgtttgcag ggattgccct ggctattttc ctaccaattt taatgattgg
   134101 gggcctcttg cttcagatag caatcggaat cgtagccatg ctagccatgc atgaactttt
   134161 gaagatgaga ggtctagcga ccatgacgat ggagggcctc ttgaccctct ttgcaacctt
   134221 tgcattgacc attcccttgg agaattacct gacttttttg ccagttgatg ggaatgtggt
   134281 tgcctatagt gttttgattt caatcatgtt aggaacgacc gtttttagca agtcttatac
   134341 gattgaggat gcggttttcc ctcttgctat gagcttctac gtgggctttg gatttaatgc
   134401 tttactagat gctcgtgttg caggtttgga caaggctctc ttagccttgt gtatcgtctg
   134461 ggcgacagac agtggtgcct atcttgttgg gatgaactat gggaaacgaa agttagcacc
   134521 aagggtatcg cctaataaaa cccttgaggg tgccttgggt ggtattttag gagcaatttt
   134581 agtaaccatt atctttatga tagttgacag tacagttgct cttccatatg gaatttacaa
   134641 gatgtcagtc tttgctattt tctttagcat tgctggacaa tttggtgatt tactagaaag
   134701 ttcgatcaaa cgtcattttg gtgttaagga ttctgggaaa tttatccctg gacatggtgg
   134761 tgttttggat cgtttcgata gtatgttgct tgtatttcca atcatgcact tatttggact
   134821 cttttaatca aaagacggag gaaacgctat gctcggaatt ttaaccttta ttctggtttt
   134881 cgggattatt gtagtggtgc acgagttcgg gcacttctac tttgccaaga aatcagggat
   134941 tttagtacgt gaatttgcca tcggtatggg acctaaaatt tttgctcaca ttggcaagga
   135001 tggaacggcc tataccattc gaatcttgcc tctgggtggc tatgtccgca tggccggttg
   135061 gggtgatgat acaactgaaa tcaagacagg aacgcctgtt agtttgacac ttgctgatga
   135121 tggtaaggtt aaacgcatca atctctcagg taaaaaattg gatcaaacag ccctccctat
   135181 gcaggtgacc cagtttgatt ttgaagacaa gctctttatc aaaggattgg ttctggaaga
   135241 agaaaaaaca tttgcagtgg atcacgatgc aacggttgtg gaagcagatg gtactgaggt
   135301 tcggattgca cctttagatg ttcaatatca aaatgcgact atctggggca aactgattac
   135361 caattttgca ggtcctatga acaattttat cttaggtgtc gttgtttttt gggttttaat
   135421 ctttatgcag ggtggtgtca gagatgttga taccaatcag ttccatatca tgccccaagg
   135481 tgccttggcc aaggtaggag taccagaaac ggcacaaatt accaagattg gctcacatga
   135541 ggttagcaac tgggaaagct tgatccaagc tgtggaaaca gaaaccaaag ataagacggc
   135601 accgactttg gatgtgacta tttctgaaaa ggggagtgac aaacaagtca ctgttacacc
   135661 cgaagatagt caaggtcgtt accttctagg tgttcaaccg ggggttaagt cagattttct
   135721 atccatgttt gtaggtggtt ttacaactgc tgctgactca gctctccgaa ttctctcagc
   135781 tctgaaaaat ctgattttcc aaccagattt gaacaagttg ggtggacctg ttgctatctt
   135841 taaggcaagt agtgatgctg ctaaaaatgg aattgaaaat atcttgtact tcttggcaat
   135901 gatttccatc aatattggga tttttaatct tattccgatt ccagccttgg atggtggtaa
   135961 gattgtgctc aatatcctag aagccatccg ccgcaaacca ttgaaacaag aaattgaaac
   136021 ctatgtcacc ttggccggag tggtcatcat ggttgtcttg atgattgctg tgacttggaa
   136081 tgacattatg cgactctttt ttagataatc gaggaatatt atgaaacaaa gtaaaatgcc
   136141 tatcccaacg cttcgcgaaa tgccaagcga tgctcaagtt atcagccatg ctcttatgtt
   136201 gcgtgctggt tatgttcgcc aagtttcagc aggtgtttat tcttatctac cacttgccaa
   136261 ccgtgtgatt gaaaaagcta aaaacatcat gcgccaagaa ttcgaaaaga ttggtgctgt
   136321 tgagatgttg gctccagccc ttcttagtgc agaattgtgg cgtgaatcag gtcgttatga
   136381 aacttacggt gaagaccttt acaaactaaa aaaccgtgaa aaatcagact ttatcttagg
   136441 tccaactcac gaagaaacct ttacagctat tgtccgtgat tctgttaaat cttacaagca
   136501 attgccactc aacctttatc aaattcagcc caagtatcgt gatgaaaaac gcccgcgtaa
   136561 tggacttctt cgtacacgtg agtttatcat gaaagatgct tatagtttcc acgctaacta
   136621 tgatagtttg gatagtgttt atgatgagta caaagcagcc tatgagcgta ttttcactcg
   136681 tagtggttta gacttcaagg ctattattgg tgacggtgga gccatgggtg gtaaggatag
   136741 ccaagaattt atggccatta catctgctcg tacagacctt gaccgctggg ttgtcttgga
   136801 caagtcagtt gcctcatttg acgaaattcc tgcagaagtg caagaagaaa tcaaggcaga
   136861 attgctcaaa tggatagtct ctggtgaaga taccattgct tactcaagtg agtctagcta
   136921 tgcagctaac ttagaaatgg caacaaacga gtacaaacca agcaaccgtg ttgtcgctga
   136981 agaagaagtt actcgtgttg caacgccaga tgttaaatca attgatgaag ttgcagcttt
   137041 cctcaatgtt ccagaagaac aaacgattaa aaccctcttc tacattgcag atggtgagct
   137101 tgttgcagcc cttctagttg gaaatgacca actcaacgaa gtcaagttga aaaaccactt
   137161 aggagcagat ttctttgacg ttgctagcga agaagaagtg gcgaatgttg ttcaagcagg
   137221 atttggttca cttggaccag ttggtttgcc agagaatatt aaaattattg cagatcgtaa
   137281 ggtgcaagat gttcgcaatg cagttgtcgg tgctaacgaa gatggctacc acttgactgg
   137341 tgtgaaccca ggccgtgatt ttacttcaga atatgtggat atccgtgaag ttcgtgaggg
   137401 tgaaatttcc ccagatggac aaggtgtcct taattttgcg cgtggtattg agatcggtca
   137461 tattttcaaa ctcggaactc gctattcagc aagcatggga gcagatgtct tggatgaaaa
   137521 tggtcgtgct gtgccaatca tcatgggatg ttacggtatc ggtgtcagcc gtcttctttc
   137581 agcagtgatg gagcaacacg ctcgcctctt tgttaacaaa acgccaaaag gtgaataccg
   137641 ttacgcttgg ggaatcaatt tccctaaaga attggcacca tttgatgtgc atttgattac
   137701 tgtcaatgtc aaggatgaag aagcgcaagc cttgacagaa aaacttgaag caagcttgat
   137761 gggagctggt tatgaagtct tgacagatga ccgtaacgaa cgtgtcggtg ttaaatttag
   137821 cgatagtgac ttgattggtc ttccaatccg tatcactgtt ggtaaaaaag cggccgatgg
   137881 cattgtagaa gttaagatca aggcaactgg tgacaccatt gaggttcatg cagataacgt
   137941 gcttgaaacg cttgaaatcc taagcaagaa ataaaaacta taatcagaag aaaaacaagg
   138001 aaaaaatgta actagttttt accttgtttt ttctgtataa tgggagaaat gagtagataa
   138061 agaggtaaat gtatgctaag atttccaaag gattttgtct ggggatcctc tacttctgga
   138121 ccgcagacag aaggacgtgt agctggtgac ggtaagggag acaatctctg ggattactgg
   138181 ttccaagtgg agccaaatcg ttactataat gggattggtt cagataagac atcgactttt
   138241 tatgaaaatt gggagcggga tattgagctt ttgttagaga ctggtcacac agcctttcgg
   138301 acttctattc agtggtcacg gatttttcca caaggctgtg gaaaagtcaa ccctcaaggt
   138361 gtggattttt atcgtaaggt ctttgaggct attaaggcta aaggaattcg tctgttagtc
   138421 aatctctatc attttgattt accttttgcc cttcaagagg atggtgatgg ttgggaaaat
   138481 aaggcgacag tctcagccta tgaagactat gctcgttttt gttttgagac ttatggagat
   138541 ttagtggatc aatggattac ctttaacgag cccatcgttc ctgtagaatt tggttatttt
   138601 tatgatgccc attatccaca taaggtggat gcagaggcag ctgttaaggt agcctatcat
   138661 acacaattgg ccagcagccg ggctgttaag gcttgccatg aacttttgcc tgattccaag
   138721 attgggattg tcctcaactt gacaccggct tatccacgta gccagcatcc tgctgatgtc
   138781 aaggcagctc gtattgcggc cctttttcag gcccaatctt tcttagatcc atctgtcttg
   138841 gggacttatc cacaggagtt ggtagaaatc ttgcatgaac acggtctttt acctgatgct
   138901 acagaggaag agttggaact cattcgtgat aatacggtgg acttccttgg tgtgaactac
   138961 tatcaacctt tgcgtgttat ggctcctcga tttgctaagc atccagagag tccactctta
   139021 ccagaacatt tttacgagcc ttatgtgatg cctggacgta aaatcaattc tcaccgtggt
   139081 tgggagattt atgagcaagg gatttatgac atcgcccaaa atatcaagga aaattatggc
   139141 aatattgagt ggatgttgac tgagaatggt atgggtgttg aaggggaaga aaaattccgt
   139201 caagatggaa tgattcaaga tgattaccgt attgactttg taaaaggtca tcttcgtgaa
   139261 cttcaccgtg ccattgaaga tggtgccaac tgtaagggct acttgatttg gacctttatt
   139321 gactgctggt catggctcaa cagctataaa aatcgctatg gtttggtcga attagacttg
   139381 gaaacgcaag aacgtcgtct gaagaaatca ggccactggt tcaaagaatt aagcgataat
   139441 aatggatttt aaaaaggact ctgactgatt atcccaatcg gtcagagttt ttatgcttac
   139501 aggagcttaa tttgaactat accaattttt actcttgaca agtgaaagaa acaagtatat
   139561 actgtttttg ctgattctat aaaagatgaa ttagactata ccaattttaa ggagaaagca
   139621 cagcttgcct gtgtcgtata tactatgtgt ggaattgttg gtgttgttgg aaacacaaat
   139681 gcaactgata ttttgattca agggcttgaa aagcttgaat accgtggcta tgattctgcg
   139741 ggaatttttg tcctagatgg tgctgataac catttggtga aggcggttgg tcgtattgca
   139801 gaattgtctg ccaagacagc tggtgttgag ggaacaactg gtatcggaca tactcgttgg
   139861 gctactcacg gaaaaccaac tgaggacaat gctcacccac accgctctga gacagaacgt
   139921 tttgtcttgg tgcataatgg ggtgattgag aactaccttg aaatcaagga agaatacctt
   139981 gcaggtcacc acttcaaggg gcagacagat actgaaatag ccgttcattt gattggaaaa
   140041 tttgcggaag aagaagggct ctcagttctt gaagccttca aaaaagccct tcacatcatc
   140101 cgtggttctt atgcctttgc cttggttgac tcacaagatc ctgaagtcat ctacgtagct
   140161 aaaaataaat caccactttt gattggtctt ggagaaggct ataacatggt ctgctcagac
   140221 gccatggcta tgattcgtga aactaaccaa tacatggaaa tccatgacca agagttggta
   140281 atcgtcaagg ctgatagtgt ggaagttcaa gactatgatg gaaatcgtcg tgagcgtact
   140341 agctacactg ctgaacttga cttgtcagat atcggtaagg gaacttaccc ttactacatg
   140401 ctcaaggaaa ttgacgagca accaactgtt atgcggaaac tcatccaagc ctacacagat
   140461 gaggctggtc aagttgtcgt agacccagat atcattaagg ctgttcaaga cgcagaccgc
   140521 atctacatcc ttgcagctgg aacatcttac catgcaggat ttgcttctaa gaaaatgttg
   140581 gaagaattga cagatacacc agttgaactt ggaatctcat ctgagtgggg ctacggtatg
   140641 ccacttctca gcaagaaacc actcttcatc tttatcagcc aatctggtga aacagcggat
   140701 agtcgtcaag ttttggtcaa ggctaatgaa atgggaattc caagcttaac agtgacaaat
   140761 gttccaggtt caaccctctc acgtgaagcc aactatacca tgctccttca cgcaggtcct
   140821 gaaattgctg tggcatcaac taaagcctat acagcgcaaa tcgcagccct tgccttcctt
   140881 gcaaaagcag tcggagaagc aaatggtaat gctaaagcgc aagtctttga tctggttcat
   140941 gaattgtcaa tcgtagctca gtctatcgaa tcaactcttt cagagaaaga aaccattgaa
   141001 gtcaaggttc gtgaacttct tgaaacaact cgtaacgcct tttacatcgg acgtggtcaa
   141061 gattactacg tagccatgga agcaagtctc aaactcaaag agatttctta tatccagtgt
   141121 gaaggctttg ctgcaggaga actcaagcac ggaaccattg ccttgattga agaaggaaca
   141181 cctgtcttgg ctctcttgtc agatccagtc cttgccaacc acactcgtgg aaatatccaa
   141241 gaggtggcag cccgtggtgc taaggtcctc actatcgcag aagaaaatgt tgctaaagat
   141301 accgacgata tcgtccttac gactgtacac ccttacctct caccaatttc aatggtcgta
   141361 ccgacgcaat tggttgctta ctttgcaacc ctccaccgtg gcctcgatgt ggataaacca
   141421 cgtaaccttg ctaaatcagt aacggtagaa taagctaaaa aagtctagtt atctaggctt
   141481 tttctaatga gcaaattggt tgcttgtact taagattcgt gttagaataa tttttcaaat
   141541 tgaaggacag agatagacaa ggagaatcac aatggtagaa ttgggaattt caacatttgg
   141601 ggaaataacg gagcttgaag ggactggaca aacttacagt catgctgaac gcattcgcca
   141661 gttggtggca gagattgagc tggctgacaa ggttggtttg gacgtatatg ggattggcga
   141721 gcaccatcgg gcggattttg cagtatcagc cccagagatt gtcctggccg ctggggcagt
   141781 caataccaag aaaatccgtt tgaccagtgc agtcagcatt ctgtcaagca tggatccgat
   141841 tcgtttgttc caacagtatg ccactatcga tgctttgtca aatggacgat cggagattat
   141901 ggctggaagg ggctctttca cggaatcttt ccctctgttt ggttatgact tgaaagacta
   141961 cgactctctt tttgatgaga aattagactt gcttcagtta gtcaatgaaa agaccaagtt
   142021 agactggcaa ggtcgattga ctcaaacgat tgctggtaaa gaagtttatc ctcgtccagt
   142081 tcaggacaaa ttgcccttgt ggatagctac aggtggtcat gtcgaatcaa cagtgaagat
   142141 tgctcaggct ggtctaccga ttgtatatgc tattattggt ggtaatccac gttattttaa
   142201 aaagttgatt caggcttatc gtgagattgg aagcgaagcg ggccatgctg acaaagactt
   142261 gaaagtggga gcccattctt gggggtggat tgcggaagat ggtgagcagg cggtgaaaga
   142321 ttatttccat ccgactaagc aagtggtgga tgctatttcc aaagaccgtc cgcactggca
   142381 ggaattgcgt tatgagcaat atttggagca ggtagggcca aatggcgcca tgtttgttgg
   142441 caatccagat caggtggccg aaaaattgat ttgcatgata gaggatttag gattggaccg
   142501 cttcatgctt catctaccgc ttggttctat gcctcatgac caggttctga gagctattga
   142561 actcttcgga acacaagttg cacccaaagt acgagcttat tttgctatga aagaggctta
   142621 ataaaaaatc ctaatcaagt ttattaggac aacaaatatt gtacgaaaat taatcccccg
   142681 agctataatg cttgggggat ttttctatag gagggctagt ttagttctct tttttatttt
   142741 ttagtaagaa accgagacca aggagcgcaa ggaggctgat tcctgcaaat aggagtttgt
   142801 tttcgttttt aattcctgta tttggaagtt cagcttgtct atctggggtt gcaggtatat
   142861 ttttcttgct agagttttct accgattcgt ttcgaaccgc ttcttttaca gatgatgctt
   142921 gtgcttcttg tgctggttgt tcagcttgtg aatcagctgt agcttggcta ggtttatttt
   142981 ccgcatcagc tactttggta tctggtttag tagaatcagg tctagcttct ggagctggat
   143041 cttgatgttc agggtgagaa gcttcatttt gatgttcagg cttggaaggg gttgagtctg
   143101 gtttctcttc tgcagttgac tcatggctag ttccattttg agagactcga agaacagtag
   143161 ctgtaagggc attcaatttc aagccttttt cagtccattc aagtcctttc gggttggcaa
   143221 ttccgactga tcctgcttgg ttttcatctg ccaaaacttc cgcatttctt agatgtgcaa
   143281 aggcagttcc caaattaaat tcgcgagctt tttcatccgc attgacaaag actgcgtaga
   143341 tatcgccgtt tggagcagtg atttgatagc caatcactac atcctctttt tccacaccat
   143401 tttggcctgg gacagtgatg aggtggacac ggtctttgat atcttgaaga ctcttaagtc
   143461 ggaaggcatc tgtagattga cgaagggcaa tcaaaccttt catatagtca cggctcttga
   143521 cattttcagg ataagcttta ccatctgtag ccttagtcca gtcaaacttg ttgactgcat
   143581 cactagaatc gtaagagtca tggatgaagt aaggatagtc aaatgggttg ccgtccttat
   143641 cacgcaacaa gtgagatttg tttggaacct tatcctctgc tactggagtc ttgtaggctg
   143701 ggtcacggaa ttgtttagta cgtccatatt cctgaccgga gtggataaat ggagttcctt
   143761 gagctgtcaa gaccatgaga tttccaagtc gtaaacgacg gtggatttca gcatagttct
   143821 cagccttgct tgggtctttt ttgatagact gggcaatgat gtcaaagagg gtcaagttat
   143881 catgggctgc gatgtattgg atgacatctc cagggctgtc agcttcaaag ttagttggtt
   143941 gagcaatgag atttttaaag atggtgttga catcacgctt gccacctgtg ataaaggcag
   144001 gttgaccttc gtttggataa ccagatttga ggttgttacg gatgtcatct gaaaagacag
   144061 cgacagtatc ggtatgtttc atccaatctt ggtcagcagc tttagtaggc atgttttcat
   144121 caccggcata ggttctccaa ccttcaccaa gcatgatgag gtttggattg agggcgcgtg
   144181 cagccttgta agcttcttcg atagaagtgg cgtcatggtc tcccatcata tcgaaacgga
   144241 agccatccac tttgtaggta tcaactaggt atttgataga gtcaattagg agccgtttgg
   144301 tcatatggtg ggttgtcccc aagcgtccac caccaaagct agttcgaggt gtgccatcgg
   144361 catccataaa gtggtagtag tttggttcca aatcttcaaa gagatcgact ttggctgtgt
   144421 ggttataaac gacatctagg atagctccca taccacgttt gtggatttcg ttgatgaggt
   144481 ttttaaattc tgcgattcgt ttttctggat tcttaggatc gcttgagtac ataccagtca
   144541 aggagaagta gttttgaggg tcatatcccc agttgtagtt gctgttgctt gaagcgtagt
   144601 cagacaagcg ttcatggttt ttcaattcat tgacaaagta gtaagacaag actggaagga
   144661 gctggatatg ggttacaccc aagtctttga gatagtctag tttttcaatg aaggcttcaa
   144721 aagtcccaaa tggtttggtc aagtcttttg caatggcagg atctgaagtg aaatcacgca
   144781 catgagcttc gtagataacg gcgtcttcac gagtcttgaa attgtgaatc ttaccataag
   144841 tcaagtcttg aggtccgagt ttagctggat ctacaaaggc ggctttagcc actttatggg
   144901 catcgtcaat cttggaatcg tcgctattcc aagcagcaag agatttagcg taaggatcga
   144961 gtgcaagaac agttttacct tgacgctcga tttggtattg ataatagtag ccagtgaaat
   145021 ctgtgattcc gagtttgttt gtgctgtcta gagtttgttt ccaagttcct ctttcccctt
   145081 tttcaagagc gacagttcca actactttgt cagggtcatt cttgtcgtag acaacaacag
   145141 aaaccttatc agcacttggt gaccaaaggg tcaaatcaac ttgttttcct tcttctttta
   145201 ggtcagctcc cagtttgcca tcatagctgt atgtctcatc tttcaggcgc cagcttgttt
   145261 tggtagtgaa ttggtcggaa ttgtagctaa cagtataagg atgttttgtg tcagagaaat
   145321 ctccgctgta ggtcactttc ttaccagctt catcgattgc aacatcggta atagttacct
   145381 tgtttcctag gtgattagtg atgttggagt gtttgaggat atcttctttt ttagcaccga
   145441 caagtgttga aaagctactt tcaatgctag aagtgcctac gtgttgggct cctgtcatac
   145501 ggatatcatg gacatagtat ggatttgtgt aaatcgattc atcatcgtct tttaggaaaa
   145561 tttggctatg atttttcaaa tctgtgaact tataattttc tttacggatt ttcacgtcgt
   145621 ctccttgttt gctctcatct agtaataaaa atccaaattc tcttgcggct tcattaagag
   145681 gaatgtcgat atagcggcca tatttgcctg tagccgtaaa gtctgttccg tcaggccatt
   145741 gagcgctact tggatttttc acatctcccc agtaccagag agatttcttg tcatagttgc
   145801 catctgtgcg gtagtagttg acgcgaacag ttcctgcagg ctgtggctcg taagagaaaa
   145861 ccttgtaatc ttggtctaac caagcttcgt tcatttttgg aactagtttt tctacagatt
   145921 tatcgccggt tagatttttt ccagctgtat tgttgatgag gaagctaatt ttcttggctt
   145981 gttctccctt taatttgaca tctaggtaat agccgtagtc atctttcttg gcatccttga
   146041 aggacaaagc tccgtttggc cagttttcag atggtttttc aacatcgtcc caagtccata
   146101 gtccttgagc atccttgttt tcttcaggaa gttttttgac atggatacgg aagtagttat
   146161 cttcgatggg ctcttctgcc ttagtttcag ttgttactgg actagtagaa gtagttggct
   146221 cacttgaacg atcttgtcca gtttgtggtg ctggatcggc tgggcttgca gcaggttttt
   146281 cttctgtttt ctctagggaa gcgtttgcat ttccaggtga agaaatatca ctttcgttct
   146341 taccagagcc agctgctgta tcagtaagag gttgggcaag ggtggttgta tttctgttgt
   146401 tgggttcgtt agtggttggt gtactttcgt cggatgagat agttggtgta gccatggcaa
   146461 gcaagacaag gcttgtgccg ataaggacag aaccagttcc atttttgagg gaacggatgc
   146521 tgtagaccat ttttttctca gtgtgagatg gtgtttttct cataatgatt ctccaatcaa
   146581 taaatttcta tatcagtata gcatgtagta aaacaatatg caagcgtttt ctttgatttg
   146641 tgaaagaaat tcttactttt gagaagtttt ccgtactatt ttatatatca gtataaatga
   146701 cggagataaa aatgtcacgt aagccaagcc gtgttattag gaagatgatg tgttctcagc
   146761 tatttttatt cagaaattga tctctaacat taccaataaa aaagaaaaat atcttgacaa
   146821 gcaagggaaa attttgttac aataatagac ggtacttttt acttttggtc tctcaagagt
   146881 gtacagggac gtgctgacaa atgttgcaaa agtacacaca gatgatatct gtcaccaagt
   146941 gtatcatcac caaaaataaa aaaacacagg agaatgtaga tgcctacaat taaccaattg
   147001 gttcgcaaac cgcgtaaatc aaaagtagaa aaatctaaat caccagcttt gaacgttggt
   147061 tacaatagtc ataaaaaagt tcaaacaaac gtttcttcac cacaaaaacg tggtgttgca
   147121 actcgtgttg gaacaatgac acctaaaaaa cctaactcag cccttcgtaa attcgctcgt
   147181 gtacgtttga gcaaccttat cgaagttact gcctacatcc caggtatcgg acacaacttg
   147241 caagagcaca gcgtggtgct tcttcgcggt ggacgtgtaa aagaccttcc aggggtacgt
   147301 taccatatcg tccgtggtgc acttgatact gcaggtgtta acgatcgtaa acaaggccgt
   147361 tctaaatacg gtactaaacg tccaaaagca taaggaaagg ggataaagag aaatgagtcg
   147421 taaaaataga gctccaaaac gtgacgtatt gccagatccg ctatacaatt cacaactagt
   147481 tactcgtctt atcaaccgcg ttatgcttga tggtaaacgt ggtactgctg cttcaatcgt
   147541 ttacggtgct tttgagcaaa tcaaagaagc tactggcaac gatgcacttg aagtatttga
   147601 aacagctatg gaaaacatca tgcctgtact tgaagtacgt gcacgtcgtg ttggtggttc
   147661 taactaccaa gtcccagttg aagttcgtcc agaacgtcgt acaacacttg gacttcgttg
   147721 gttggtaaca atcgctcgtc ttcgtggtga acacacaatg caagaccgtc ttgcaaaaga
   147781 aatcttggat gctgctaaca acactggtgc agcagttaag aaacgtgaag atactcaccg
   147841 tatggctgaa gctaaccgtg cattcgcaca cttccgttgg taagatagga tgcgaaagcg
   147901 ttaagaaagt cccagagaaa atagggaatc gaagcaggtt gcggttgcaa ccaatgagat
   147961 tcatcttttt ctccagactt ttagcttgag ctcaactaaa tcatgatgct aggaacggta
   148021 aggatgcaag gtaaaaatag gaaactgacg cagtattcga cgaatacaag gagttttatc
   148081 tttttcacgc agcatcccgt tccagctcac atcggctaac taactttagc ccgggttcaa
   148141 attagctaaa tcgattagta ttagctataa ctcagcttac catctcgtaa gttgaaacca
   148201 acaatagcat gaaaacattg agaacgggta ggtcctgcct atccgttttt attaaaatcg
   148261 tgttataata gaatagaaat caaaaataaa taggagaaac aaacctcatg gcacgcgaat
   148321 tttcacttga aaaaactcgt aatatcggta tcatggctca cgtcgatgcc ggtaaaacaa
   148381 caactactga gcgtattctt tactacactg gtaaaatcca caaaatcggt gaaactcacg
   148441 aaggtgcgtc acaaatggac tggatggagc aagagcaaga acgtggtatc acgatcacat
   148501 ctgctgcgac gacagctcaa tggaacaacc accgcgtaaa catcatcgac acaccaggac
   148561 acgtggactt cacaatcgaa gtacaacgtt ctcttcgtgt attggatggt gcggttaccg
   148621 ttcttgactc acaatcaggt gttgagcctc aaactgaaac agtttggcgt caagcaactg
   148681 agtacggagt tccacgtatc gtatttgcca acaaaatgga caaaatcggt gctgacttcc
   148741 tttactctgt aagcacactt cacgatcgtc ttcaagcaaa tgcacaccca atccaattgc
   148801 caatcggttc tgaagatgac ttccgtggta tcattgactt gatcaagatg aaagctgaaa
   148861 tctatactaa cgaccttggt acggatatcc ttgaagaaga catcccagct gaataccttg
   148921 accaagctca agaataccgt gaaaaattga ttgaagcagt tgctgaaact gacgaagaat
   148981 tgatgatgaa atacctcgaa ggtgaagaaa tcactaacga agaattgaaa gctggtatcc
   149041 gtaaagcgac tatcaacgtt gaattcttcc cagtattgtg tggttcagcc ttcaaaaaca
   149101 aaggtgttca attgatgctt gatgcggtta tcgactacct tccaagccca cttgacatcc
   149161 cagcaatcaa aggtattaac ccagatacag acgctgaaga aattcgtcca gcatctgacg
   149221 aagagccatt tgcagctctt gccttcaaga tcatgactga cccattcgta ggtcgtttga
   149281 cattcttccg tgtttactca ggtgttcttc aatcaggttc atacgtattg aatacttcta
   149341 aaggtaaacg tgaacgtatc ggacgtatcc ttcaaatgca cgctaacagc cgtcaagaaa
   149401 tcgacactgt ttactcaggt gatatcgctg ctgccgttgg tttgaaagat actacaactg
   149461 gtgactcatt gacagatgaa aaagctaaaa tcatccttga gtcaatcaac gttccagaac
   149521 cagttatcca attgatggtt gagccaaaat ctaaagctga ccaagacaag atgggtatcg
   149581 cccttcaaaa attggctgaa gaagatccaa cattccgcgt tgaaacaaac gttgaaactg
   149641 gtgaaacagt tatctcaggt atgggtgaac ttcaccttga cgtccttgtt gatcgtatgc
   149701 gtcgtgagtt caaagttgaa gcgaacgtag gtgctcctca agtatcttac cgtgaaacat
   149761 tccgcgcttc tactcaagca cgtggattct tcaaacgtca gtctggtggt aaaggtcaat
   149821 tcggtgatgt atggattgaa tttactccaa acgaagaagg taaaggattc gaattcgaaa
   149881 acgcaatcgt cggtggtgtg gttcctcgtg aatttatccc agcggttgaa aaaggtttgg
   149941 tagaatctat ggctaacggt gttcttgcag gttacccaat ggttgacgtt aaagctaagc
   150001 tttatgatgg ttcatatcac gatgtcgact catctgaaac tgccttcaag attgcggctt
   150061 cactttccct taaagaagct gctaaatcag cacaaccagc tatccttgaa ccaatgatgc
   150121 ttgtaacaat cactgttcca gaagaaaacc ttggtgatgt tatgggtcac gtaactgctc
   150181 gtcgtggacg tgtagatggt atggaagcac acggtaacag ccaaatcgtt cgtgcttacg
   150241 ttccacttgc tgaaatgttc ggttacgcaa cagttcttcg ttctgcatct caaggacgtg
   150301 gtacattcat gatggtattt gaccactacg aagatgtacc taagtcagta caagaagaaa
   150361 ttattaagaa aaataaaggt gaagactaat ccgtcctcac tctagaagga agtcacttag
   150421 tggcttcctt ttgtctttag aaaatacctc taaatatggt aaaatagtag aagaataatg
   150481 tgaggaaaat gaatgtcaaa tagttttgaa attttgatga atcaattggg gatgcctgct
   150541 gaaatgagac aggctcctgc tttagcacag gccaatattg agcgagttgt ggttcataaa
   150601 attagtaagg tatgggagtt tcatttcgta ttttctaata ttttaccgat tgaaatcttt
   150661 ttagaattaa agaaaggttt gagcgaagaa ttttctaaga caggcaataa agctgttttt
   150721 gaaattaagg ctcggtctca agaattttca aatcagctct tgcagtccta ctatagggag
   150781 gctttctctg aaggtccatg tgctagtcaa ggttttaagt ccctttatca aaatttgcaa
   150841 gttcgtgctg agggtaatca gctatttatt gaaggatctg aagcgattga taaggaacat
   150901 tttaagaaga atcatcttcc taatttagcc aaacaacttg aaaagtttgg ttttccaact
   150961 tttaactgtc aagtcgagaa gaatgatgtc ctgacccaag agcaggaaga ggcctttcat
   151021 gctgaaaatg agcagattgt tcaagctgcc aatgaggaag cgctccgtgc tatggaacaa
   151081 ctggagcaga tggcacctcc tccagcggaa gagaaaccag tctttgattt tcaagcgaaa
   151141 aaagctgcag ctaaacccaa gctggataag gcggagatta ctcctatgat cgaagtgacg
   151201 acagaggaaa atcgtctggt atttgaaggg gttgtttttg atgtggagca aaaagtgact
   151261 agaacaggtc gtgttttaat caactttaaa atgacggact atacttcaag tttttctatg
   151321 caaaagtggg ttaaaaacga ggaagaggcc cagaagtttg acctcatcaa gaagaattct
   151381 tggctccgag ttcgagggaa tgtggagatg aataacttca cacgcgattt gactatgaac
   151441 gtacaggatc tgcaggaagt tgttcactat gagcggaagg atttgatgcc agaaggtgag
   151501 cgtcgggttg agtttcatgc tcatactaac atgtcgacta tggatgcttt gccagaggtc
   151561 gaagagattg ttgcaacagc tgctaagtgg ggacacaagg cggttgctat cacggaccat
   151621 gggaatgtcc agtcctttcc acatggctat aaggcggcta agaaagcggg aatccagctg
   151681 atctatggga tggaagccaa tatcgtggag gaccgtgtcc ctatcgtcta taacgaagtg
   151741 gagatggact tgtcagaagc aacctacgtg gtctttgacg tggaaacgac gggactttca
   151801 gctatctata atgacttgat tcaggttgcg gcttctaaga tgtacaaggg gaatgttatt
   151861 gctgaatttg atgaatttat caatcctggg catcccttgt cagcctttac tacagagtta
   151921 actggaatta cagatgatca tgtcaaaaat gccaaaccac tagaacaagt tttgcaagaa
   151981 ttccaagaat tttgcaagga tacggtccta gttgcccaca atgctacctt tgacgttggc
   152041 tttatgaatg ctaattatga gcggcatgat cttccaaaga ttagtcagcc agttattgat
   152101 acgctggagt ttgctagaaa cctctatcct gagtataaac gccatggttt ggggcctttg
   152161 accaagcgtt ttggtgtggc cttggaacat caccacatgg ccaactacga tgcggaagcg
   152221 actggtcgtc tgcttttcat ctttatcaaa gaggtagcag aaaaacatgg tgtgaccgat
   152281 ttagctagac tcaacattga tctaatcagt ccagattctt acaaaaaagc tcggatcaag
   152341 catgcgacca tctatgtcaa gaatcaggta ggtctaaaaa atatctttaa gctggtttcc
   152401 ttgtctaata ccaagtattt tgaaggagtg ccacggattc cgagaacggt tctagatgcc
   152461 catcgagagg gcttgatttt aggttcagcc tgttcagagg gtgaagtttt tgacgtggtc
   152521 gtttctcaag gtgtggatgc ggcggttgag gtggccaagt attatgattt tatcgaggtc
   152581 atgccaccgg ctatctatgc acccttgatt gccaaagagc aggtcaagga tatggaggaa
   152641 ctccagacca ttatcaagag tttgatagag gttggagacc gccttggcaa gcctgttctg
   152701 gctacgggaa atgttcacta tatcgaaccg gaagaagaga tttatcgtga aattatcgtc
   152761 cgtagtttgg gacagggtgc gatgattaat cgaactatcg gtcatggtga acatgcccaa
   152821 ccagcaccac ttccaaaggc tcattttcga acgactaatg agatgttgga tgaatttgcc
   152881 tttttgggag aggaactggc tcgtaaactg gttattgaaa acaccaatgc cttggcagaa
   152941 atatttgaat ccgttgaagt cgttaagggt gacttgtata cgcctttcat cgacaaggct
   153001 gaagaaacag ttgctgagtt gacctataag aaagcttttg agatttatgg aaatccgctg
   153061 ccagatattg ttgatttgcg gattgaaaaa gaattaacat ccatactggg gaatggattt
   153121 gctgtgattt atctggcatc gcagatgctg gtgcaacgtt ctaatgaacg gggttatttg
   153181 gttggttctc gtgggtctgt cggatctagt ttcgttgcga ccatgattgg gattacggag
   153241 gtcaatcctc tctctcctca ctatgtctgt ggtcagtgtc agtacagtga gtttatcaca
   153301 gatggttcgt acggttcagg atttgatatg ccccataagg actgtccaaa ctgtggtcac
   153361 aaactcagta aaaacggaca ggatattccg tttgagacct tccttggttt tgatggggat
   153421 aaggttcctg atattgactt gaacttctcg ggagaagatc agcctagcgc ccacttggat
   153481 gtgcgtgata tctttggtga agaatatgcc ttccgtgcgg gaacggttgg tacggtagct
   153541 gccaagactg cctatggatt tgtcaagggt tacgagcgag attatggcaa gttttatcgt
   153601 gatgcagaag tagaacgcct cgctcaagga gcggcgggtg tcaagcggac aacaggccaa
   153661 cacccggggg gaatcgttgt tattccgaac tacatggatg tctacgattt tacgcctgtc
   153721 cagtatccag cagatgatgt cacggctgaa tggcagacca ctcactttaa cttccacgat
   153781 atcgatgaga acgtcctcaa actcgatgta ctgggacatg atgatccgac catgattcga
   153841 aaacttcagg atttgtctgg tattgaccct aataaaattc ctatggatga cgaaggcgtg
   153901 atggcactct tttctgggac tgatgtacta ggggtaacac ctgaacaaat tggaacgcct
   153961 acgggtatgt tggggattcc agagtttgga acaaatttcg tacgtggaat ggtagacgaa
   154021 acccatccga caacctttgc ggaattgctt cagctgtctg gtctgtccca cggtactgac
   154081 gtttggttgg ggaatgctca ggatctgatt aagcaaggaa tagcggacct atcgactgtt
   154141 atcggttgtc gggacgacat catggtttac ctcatgcatg cgggtctgga acctaagatg
   154201 gcctttacca ttatggaacg ggtacgtaag ggtttgtggc taaagatttc agaagaggag
   154261 agaaatggct atatcgaagc catgaaggct aataaggtgc cagagtggta tatcgaatcc
   154321 tgtgggaaaa ttaagtacat gttccctaag gcccatgcgg cagcctacgt tatgatggcc
   154381 ttgcgtgtag cttacttcaa ggttcaccat cctatttatt actactgtgc ttacttctcc
   154441 attcgtgcta aggcttttga tatcaagacc atgggtgcgg gcttggaggt catcaagcgc
   154501 agaatggaag aaatctctga aaaacggaag aacaatgaag cctctaatgt ggaaatcgat
   154561 ctctatacaa ctcttgagat tgtcaatgag atgtgggaac gaggtttcaa gtttggtaaa
   154621 ttagatctct accgtagtca ggcgacagag ttcctcatcg acggggatac ccttatccca
   154681 ccatttgtag caatggatgg tctgggagag aacgttgcca agcaactggt gcgggcgcgt
   154741 gaagagggag aattcctctc taaaacagaa ctacgcaagc gtggtggact ctcatcaacc
   154801 ttggttgaaa agatggatga gatgggtatt cttggaaata tgccagagga taaccagttg
   154861 agtttgtttg atgagttgtt ttaaaaaatt gcttaataat ctattaaaag aggctaacgt
   154921 atatccaata gatttacatt agctttcttt tttgttaaaa tagtctatgg aaagagggtg
   154981 agagtatgtc aaagatgagt ataagcatcc gtctggatag tgaggttaag gagcaggccc
   155041 aacaggtgtt tagtaatctg ggaatggata tgacaacagc tattaatatt ttccttcgtc
   155101 aggcaattca atatcaggga ttaccttttg atgttagact agacgaaaat cggaagttgc
   155161 tccaagcgtt aacggattta gaccaaaatc gtaatatgag ccagtctttt gaatcagtct
   155221 cagatttgat ggaggactta cgtgcttaag attcgttatc ataaacagtt taaaaaagat
   155281 tttaagttgg ctatgaagcg tggtttgaag gcagaattat tagaagaagt tttgaatttt
   155341 ctggttcaag aaaaagaaca tcctgccaga tatcgtgatc attcattgac ggcatccaag
   155401 cattttcaag gagttcgtga atgccatacc cagccagatt ggcttttggt ttataaagta
   155461 gacaagtcgg aattgatttt aaatttgctg aggacaggca gtcacagtga tttattttaa
   155521 tctattttaa gggggttctc atgaaactaa gaatatttgc ggaagataag ccggctaaga
   155581 aggtatttga atatcaatta gaacttgctg atcgtacaat tcttctatcg acagcactct
   155641 tgtcaggtgc tattgcttta gcaggaatct tttctgcttt gaaagaaaaa taaaaataga
   155701 aaagagaaaa cagaatggtt ttaccaaatt ttaaagaaaa tctaggaaaa tatgcgaaat
   155761 tgttggttgc gaacggaatt aacgtgcaac ctggtcacac tttggctctc tctattgatg
   155821 tggagcaacg tgaattggca catctaatcg tgaaagaagc ttatgccttg ggtgcgcatg
   155881 aggtcatcgt tcagtggaca gatgatgtga ttaaccgtga gaaattcctc catgccccga
   155941 tggagcgttt ggacaatgtg ccagaataca agattgctga gatgaactat cttttggaga
   156001 acaaggctag ccgtcttggg gttcgttcat ctgatccagg tgccttgaac ggagtggacg
   156061 ctgacaagct ttcagcttct gctaaagcta tgggacttgc catgaagcct atgcgtatcg
   156121 caactcaatc taacaaggtt agctggactg tagcagccgc tgctggactt gagtgggcta
   156181 agaaagtctt cccaaatgct gcgagcgacg aagaagcagt tgatttcctt tgggatcaaa
   156241 tcttcaaaac ttgtcgtgtc tacgaagcag atcctgttaa ggcttgggag gaacatgcag
   156301 ccattctcaa gagcaaggcc gatatgctta ataaggagca attttcagcc cttcactaca
   156361 cagcgccagg aacagattta acacttggtt tgccaaagaa ccacgtttgg gaatcagctg
   156421 gtgctgtcaa tgcacagggc gaagaattct tgccaaatat gccgacagaa gaggtcttca
   156481 cagcgcctga cttccgtcgt gcagatggtt atgtcacttc tacaaaaccg cttagctaca
   156541 acggaaatat cattgaaggc attaaggtga cctttaagga tggacaaatc gtagatatca
   156601 ctgctgagaa gggtgatcag gttatgaaag accttgtctt tgaaaatgcg ggtgcgcgtg
   156661 ccttgggtga atgtgccttg gtaccagatc caagtccaat ttctcagtca ggcattacct
   156721 tttttaacac ccttttcgat gaaaatgcgt caaaccactt ggctatcggt gcagcctatg
   156781 cgactagcgt tgttgatgga gcggagatga gcgaagagga gcttgaagct gcagggctta
   156841 accgttcaga tgttcacgta gactttatga ttggttctaa ccaaatggat atcgatggta
   156901 ttcgtgagga tggaacgcgg gtacctcttt tccgtaatgg gaattgggca aattaaggag
   156961 ataatatgtt aggaagtatg ttcgttggtc tcctagtggg atttttagca ggtgctatga
   157021 ccaatcgtgg agagcgaatg ggatgttttg gaaaaatgtt tctcggttgg atcggagcct
   157081 ttctaggtca cttgctcttt ggaacttggg ggccagtttt atcaggaaca gctattatcc
   157141 cagcgatttt aggagccatg attgttttag ctattttttg gagacgagga agttaatttc
   157201 ctaaatctga tactcaatga aaatcaaaga gcaaactagg aaactagccg caggttgctc
   157261 aaagcactg
//
LOCUS       DBERMM010000002       103825 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.002, whole genome shotgun sequence.
ACCESSION   DBERMM010000002 DBERMM010000000
VERSION     DBERMM010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 103825)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 103825)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..103825
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.002"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(166..1914)
                     /locus_tag="ACL8AS_000169"
     CDS             complement(166..1914)
                     /locus_tag="ACL8AS_000169"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228110.1"
                     /translation="MKRQTVNQTLKRLVVDLASHPFLLFLAFLGTIAQVGLSIYLPIL
                     IGQVIDQVLVAGSSPVFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRDLRERII
                     HKLHRLPIAFVDRQGSGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQI
                     HLLMTLLVLLLTPLSMVISRFIAKKSYHLFQKQTETRGIQTQLIEESLSQQTIIQSFN
                     AQTEFIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGSA
                     LTVGRLVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLT
                     SDQVKGAISFKHVSFGYHPEKILIKDLSIDIPAGSKIAIVGPTGAGKSTLINLLMRFY
                     PISSGDILLDGQSIYDYTRASLRQQFGMVLQETWLTQGTIHDNIAFGNPEASREQVIA
                     AAKAANADFFIQQFPQGYDTKLENAGESLSVGQAQLLTIARVFLAIPKILILDEATSS
                     IDTRTEVLVQDAFAKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMDR
                     KGKYYQMQKAAAFSSE"
     gene            complement(1916..3640)
                     /locus_tag="ACL8AS_000170"
     CDS             complement(1916..3640)
                     /locus_tag="ACL8AS_000170"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228111.1"
                     /translation="MKHLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSL
                     PQGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGFAKELTNDLYRHILSLPKD
                     SRDRLTTSSLVTRLTSDTYQIQTGINQFLRLFLRAPIIVFGAIFMAYRISAELTFWFL
                     VMVAILTIVIVGLSRLVNPLYSSLRKKTDQLVQETRQQLQGTRVIRAFGQEKRELQIF
                     QTLNQVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALI
                     NYLLQILVELVKLAMLITSLNQSYISAKRIEEVFAESPENIHSELEQKQVTSDRVLQV
                     QELTFTYPDAAQPSLRDISFDMTQGQILGIIGGTGSGKSSLVQLLLGLYPVDKGNIDL
                     YQNGRSPLNLEQWRSWIAYVPQKVELFKGTIRSNLTLGFNQEVSDQELWQALEIAQAK
                     DFVSEKEGLLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESK
                     LLKAIRENFPNTSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYCEIN
                     ASQHGKED"
     gene            complement(3698..4636)
                     /gene="msrB"
                     /locus_tag="ACL8AS_000171"
     CDS             complement(3698..4636)
                     /gene="msrB"
                     /locus_tag="ACL8AS_000171"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA];
                     GO_process: GO:0006979 - response to oxidative stress
                     [Evidence IEA];
                     GO_process: GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HGS1228112.1"
                     /translation="MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLI
                     KETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEAD
                     LPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
                     LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPL
                     FFAKDKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPR
                     ELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK"
     gene            complement(4886..5755)
                     /gene="thrB"
                     /locus_tag="ACL8AS_000172"
     CDS             complement(4886..5755)
                     /gene="thrB"
                     /locus_tag="ACL8AS_000172"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000692406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004413 - homoserine kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HGS1228113.1"
                     /translation="MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEERDEWLIEHQI
                     GKWIPHDERNLLLKIALQIVPDLQPRRLKMTSDVPLARGLGSSSSVIVAGIELANQLG
                     QLNLSDHEKLQLATKIEGHPDNVAPAIYGNLVIASSVEGQVSAIVADFPECDFLAYIP
                     NYELRTRDSRSVLPKKLSYKEAVAASSIANVAVAALLAGDMVTAGQAIEGDLFHERYR
                     QDLVREFAMIKQVTKENGAYATYLSGAGPTVMVLASHDKMPTIKAELEKQPFKGKLHD
                     LRVDTQGVRVEAK"
     gene            complement(5757..7043)
                     /locus_tag="ACL8AS_000173"
     CDS             complement(5757..7043)
                     /locus_tag="ACL8AS_000173"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004412 - homoserine dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HGS1228114.1"
                     /translation="MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVK
                     DEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVV
                     TANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
                     GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMK
                     IAFDDVAHKGIRNITPEDVAVAQEFGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLA
                     SVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEY
                     SRDLVLANPEDVKANYYFSILAPDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARV
                     VIITHKINKAQLENVSAELKKVSEFDLLNTFKVLGE"
     gene            complement(7194..7931)
                     /gene="mecA"
                     /locus_tag="ACL8AS_000174"
     CDS             complement(7194..7931)
                     /gene="mecA"
                     /locus_tag="ACL8AS_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adaptor protein MecA"
                     /protein_id="HGS1228115.1"
                     /translation="MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAI
                     LDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMS
                     PDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
                     KLADLVVFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDS
                     DISRSVLQEYGQVLMSHDAVLNLQKIG"
     gene            complement(8131..9165)
                     /locus_tag="ACL8AS_000175"
     CDS             complement(8131..9165)
                     /locus_tag="ACL8AS_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HGS1228116.1"
                     /translation="MFEHYSVADLFANLYKKRKANILALIALFALIAVPFTIKAVRNK
                     NTVKDTTSYSTYLIYKITPPEDSAKTILNHQIGGYSDFYGKLIDGNLNGAYLFNDVEP
                     SELKKIASELDTTETTLKNSTNDYWWKKLTVYYMIDDAGVGVKILTSSKDANDLLEKK
                     IDGLIEKFKHAYANVKIEKLETINSKELNANGETALGLNVKNLILRLVVIGVVCVILV
                     VMGNVLVYLFNPTINRVGDFSQYQIDFVTEITTIANLADVLSYKNTGQELTIVSSNKA
                     ILDKLKQSQEALKGMHFVDLQDVSSLLERDTVLLVEEYGVTRYKKFEQSLQILRNLNR
                     SILGVATFKL"
     gene            complement(9194..10627)
                     /locus_tag="ACL8AS_000176"
     CDS             complement(9194..10627)
                     /locus_tag="ACL8AS_000176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polysaccharide polymerase Wzy family
                     protein"
                     /protein_id="HGS1228117.1"
                     /translation="MIDGKRLLFSLTIVSYALTLVSGIVYLFNNNNVSLLSTLLFLLV
                     SSLIACWNDIKYYLIHFIFYLTIFVFLVSRPTIDYFRDGALDTYHPIAYRFAFIVVMV
                     SILGLTTGGILARYFIARKKIKVANIGNSLKEVYIKRLRFVSLVVFLLTYPFYFIRLF
                     ERLLYRLQTSYYAYYANFESKLPYFTYILSTFTVYAMCMYLATKPKKLQATAVLVSFI
                     AANTIHLAIGTRNPFILSILFAFVYYFMREQTEKGKWIGFKEKLAIFVGSPILMLAMG
                     VLNYVRDNVQVSHTGFWDILLDFIYKQGTSFGVLARGFLFNSSLPYRDFRNFTFGPVL
                     DYFARGSLGAIFGGKAFEHTTNSVELAIDSNSYAHNLSYLVLNKEYLKGHGIGSSYIM
                     ELYTDYGMIGVFLLSFLLGVLFIAMLQVAYRSRTILFALSLLILNNLFFMPRSSFSES
                     FFNLFTMQFWGIVLVIIFVAKMLTKEN"
     gene            complement(10643..11629)
                     /locus_tag="ACL8AS_000177"
     CDS             complement(10643..11629)
                     /locus_tag="ACL8AS_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000446977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1228118.1"
                     /translation="METALISVIVPVYNVAQYLEKSIASIQKQTYQNLEIILVDDGAT
                     DESGRLCDSIAEQDARVSVLHKKNEGLSQARNDGMKQAHGDYLIFIDSDDYIHPEMIQ
                     SLYEQLVQEDADVSSCGVMNVYANDESPQSANQDDYFVCDSQTFLKEYLIGEKIPGTI
                     CNKLIKRQIATALSFPKGLIYEDAYYHFDLIKLAKKYVVNTKPYYYYFHRGDSITTKP
                     YAEKDLAYIDIYQKFYNEVVKNYPDLKEVAFFRLAYAHFFILDKMLLDDQYKQFEAYS
                     QIHRFLKGHAFAISRNPIFRKGRRISALALFINISLYRFLLLKNIEKSKKLH"
     gene            complement(11631..12734)
                     /locus_tag="ACL8AS_000178"
     CDS             complement(11631..12734)
                     /locus_tag="ACL8AS_000178"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HGS1228119.1"
                     /translation="MVAKKKILFFMWSFSLGGGAEKILSTIVSNLDPEKYDIDILEME
                     HFDKGYESVPKHVRILKSLQDYRQTRWLRAFLWRMRIYFPRLARRLLVKDDYDVEVSF
                     TIMNPPLLFSKRREVKKISWIHGSIEELLKDSSKRESHRSQLDAANTIVGISKKTSNS
                     IKEVYPDYASKLQTIYNGYDFQTILEKSQEKIDIEIAPQSICTIGRIEENKGSDRVVE
                     VIRLLHQEGKNYHLYFIGAGDMEEELKKRVKEYGIEDYVHFLGYQKNPYQYLSQTKVL
                     LSMSKQEGFPGVYVEALSLGLPFISTDVGGAEELSQEGRFGQIIESNQEAAQAITNYM
                     TSASNFDVDEASQFIQQFTITKQIEQVEKLLEE"
     gene            complement(12724..13569)
                     /locus_tag="ACL8AS_000179"
     CDS             complement(12724..13569)
                     /locus_tag="ACL8AS_000179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HGS1228120.1"
                     /translation="MNNMTDLKAIQARSLEMAEYFVAFCKEHDLLCYLCGGGAIGALR
                     NKGFIPWDDDLDFFMPRKDYEKLAELWPRYADERYFLSKSHKNFVDRNLFITIRDKET
                     TCIKPYQQDLDLPHGLALDILPLDYYPKNPAERKKQVRWALIYSLFCAQTIPEKHGAL
                     MKWGSRILLGLTPKSLRYRIWKKAEKEMTKYDLADCDGITELCSGPGYMRNKYPITSF
                     EDNLFLPFEGTEMPIPIGYDVYLRTAFGDYMTPPPADKQVPHHDTVIADMDKSYTKYK
                     GEYGG"
     gene            complement(13848..15122)
                     /gene="psr"
                     /locus_tag="ACL8AS_000180"
     CDS             complement(13848..15122)
                     /gene="psr"
                     /locus_tag="ACL8AS_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyisoprenyl-teichoic acid--peptidoglycan
                     teichoic acid transferase Psr"
                     /protein_id="HGS1228121.1"
                     /translation="MSKENPLSHHEQLRYDYLLKNIHYLNEREKNEFAYLQEKLTLAR
                     GNSSSSLEQEREEQVDLPSYANRSRSQSKSQALSFPPKKKRRKLRLKRIFMVIFSLLV
                     CVALAMVFMFLRGYQDASAKKTADARAAQVEVFNGQDTRDGVNILIMGTDGRIGQNSV
                     ETRTDSIMVLNVGGSDKKMKLVSFMRDNLVYIDGYSQVINGRKQTDNKLNVAYELGEQ
                     EGQKGAEMVRQVLKDNFDLDIKYYALVDFQAFATAIDTLFPDGVTIDAQFSTLNGRPL
                     TEATVGDDLYATETESPTQTIKVGKQQMNGSTLLNYARFRDDDEADYGRTKRQQQVLT
                     AILEQIKDPTKLFTGSEALGKVFAMTSTNVPYTFLLTNGLSVLDGAKNGIEKLTIPEL
                     GDWVDAYDVYGGLGLLVDQNKYQTKLAQMGLR"
     gene            complement(15119..15967)
                     /gene="pheA"
                     /locus_tag="ACL8AS_000181"
     CDS             complement(15119..15967)
                     /gene="pheA"
                     /locus_tag="ACL8AS_000181"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004664 - prephenate dehydratase activity
                     [Evidence IEA];
                     GO_process: GO:0009094 - L-phenylalanine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HGS1228122.1"
                     /translation="MKIAYLGPKGSFSHHVVQTAFPHEELQAFANITDVIKAYEQGLV
                     DYSVVPVENSIEGSVHETLDYLFHQAHIQAVAEIVQPIHQQLMVVPGHTKIEKIFSHP
                     QALAQGKKFIDEQYPEAQIEVTVSTAYAARFISEHPDQPFAAIAPRSSAEEYGLELIA
                     EDIQEMEANFTRFWLLGAEKPSIPLQAQTEKMSLALTLPDNLPGALYKALSTFAWRGI
                     DLTKIESRPLKTALGEYFFIIDVDYTDKDLVHFAQKELEAIGIQYKILGAYPIYPISD
                     HGKERR"
     gene            complement(15964..16440)
                     /locus_tag="ACL8AS_000182"
     CDS             complement(15964..16440)
                     /locus_tag="ACL8AS_000182"
                     /EC_number="2.7.1.71"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0004765 - shikimate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HGS1228123.1"
                     /translation="MAKVLLGFMGAGKSTIARGLDPNYLDMDALIEKRLGMSIANFFA
                     EKGEAAFRQVESEVLADLLQRDQVVSTGGGVVISQRNRDLLKTNTDNIYLKADFETLY
                     LRIAADKDNQRPLFLNNSKEELVAIFQERQAWYEEVASRVLDVTKLSPEEIIEELR"
     gene            complement(16433..17716)
                     /gene="aroA"
                     /locus_tag="ACL8AS_000183"
     CDS             complement(16433..17716)
                     /gene="aroA"
                     /locus_tag="ACL8AS_000183"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HGS1228124.1"
                     /translation="MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILR
                     GEDVLSTMQVFRDLGVEIEDKDGVITVQGVGMAGLKAPQNALNMGNSGTSIRLISGVL
                     AGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHY
                     ELPIASAQVKSALMFAALQAKGESVIIEKEYTRNHTEDMLQQFGGHLSVDGKKITVQG
                     PQKLTGQKVVVPGDISSAAFWLVAGLIAPNSRLVLQNVGINETRTGIIDVIRAMGGKL
                     EITEIDPVAKSATLIVESSDLKGTEICGALIPRLIDELPIIALLATQAQGVTVIKDAE
                     ELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAI
                     AALLVADGEVELDRAEAINTSYPSFFDDLESLIHG"
     gene            complement(17808..18146)
                     /locus_tag="ACL8AS_000184"
     CDS             complement(17808..18146)
                     /locus_tag="ACL8AS_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbF/YmcA family competence regulator"
                     /protein_id="HGS1228125.1"
                     /translation="MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTEY
                     LAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKI
                     VFEPVSELLK"
     gene            complement(18157..19260)
                     /locus_tag="ACL8AS_000185"
     CDS             complement(18157..19260)
                     /locus_tag="ACL8AS_000185"
                     /EC_number="1.3.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HGS1228126.1"
                     /translation="MAKTIYIAGLGLIGASMALGIKRDHPDYEILGYNRSQASRDIAL
                     KEGMIDRATDDFASFAPLADVIILSLPIKQTIAFIKELANLDLREGVIISDAGSTKST
                     IVDAAEQYLAGKSVRFVGAHPMAGSHKTGAASADVNLFENAYYIFTPSSLTSQDTLKE
                     MKDLLSGLHARFIEIDAKEHDRVTSQISHFPHILASSLMEQTAVYAQEHEMARRFAAG
                     GFRDMTRIAESEPGMWTSILLSNSETILDRIEDFKERLEAIGQAISKGDEEQIWNFFN
                     QAREQRQTMEIHKRGGVDSSYDLYVDVPDEEDVILRILELLRGTSLVNIHINEENRED
                     IHGILQISFKNAQDLERAEHLITKNTDYTVVIK"
     gene            complement(19270..20436)
                     /gene="aroC"
                     /locus_tag="ACL8AS_000186"
     CDS             complement(19270..20436)
                     /gene="aroC"
                     /locus_tag="ACL8AS_000186"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004107 - chorismate synthase activity
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HGS1228127.1"
                     /translation="MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYG
                     RGGRMKIESDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSKRK
                     ITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANH
                     VVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVV
                     ETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEI
                     LWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKAT
                     VERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY"
     gene            complement(20446..21513)
                     /gene="aroB"
                     /locus_tag="ACL8AS_000187"
     CDS             complement(20446..21513)
                     /gene="aroB"
                     /locus_tag="ACL8AS_000187"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002308136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003856 - 3-dehydroquinate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HGS1228128.1"
                     /translation="MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNH
                     VASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVAL
                     GGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQP
                     DGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLI
                     EHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISK
                     IAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVP
                     ELGSATIHPVSLEEMKDYLVK"
     gene            complement(21532..22386)
                     /locus_tag="ACL8AS_000188"
     CDS             complement(21532..22386)
                     /locus_tag="ACL8AS_000188"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HGS1228129.1"
                     /translation="MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEI
                     EASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLI
                     GYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEK
                     TRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVL
                     PETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIW
                     QSLTEKYQ"
     gene            complement(22376..23053)
                     /gene="aroD"
                     /locus_tag="ACL8AS_000189"
     CDS             complement(22376..23053)
                     /gene="aroD"
                     /locus_tag="ACL8AS_000189"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HGS1228130.1"
                     /translation="MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQV
                     APAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQFYQPDYIDFEYYSYKD
                     VFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNY
                     TRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKI
                     REILDEA"
     gene            complement(23050..24213)
                     /locus_tag="ACL8AS_000190"
     CDS             complement(23050..24213)
                     /locus_tag="ACL8AS_000190"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent rRNA methyltransferase"
                     /protein_id="HGS1228131.1"
                     /translation="MNRIRVSKRVEKKLAKGLVLLEASDLENVNLKDQEVEVQGQEGN
                     FLGTAYLSQQNKGLGWFVSKDKVAFNQAFFETLFRKAKEKRSAYYQDDLTTTYRLFNQ
                     EGDGFGGLTVDLYGNYAVFSWYNSYVYQIRQTISEAFRQVFPEVLGAYEKIRFKGLDY
                     ESAHVYGQEAPDFFTVLENGVLYQVFMNDGLMTGIFLDQHEVRGSLVDGLTMGKSLLN
                     MFSYTAAFSVAAAMGGASQTTSVDLAKRSRELSQAHFQANGLSTDEHRFIVMDVFEYF
                     KYAKRKDLTYDVIVLDPPSFARNKKQTFSVAKDYHKLISQSLEILNPGGIIIASTNAA
                     NVSRQKFTEQIDKGFAGRSYQILNKYGLPADFAYNKKDESSNYLKVISMKVSK"
     gene            complement(24897..26531)
                     /locus_tag="ACL8AS_000191"
     CDS             complement(24897..26531)
                     /locus_tag="ACL8AS_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228132.1"
                     /translation="MRLKVIKKLVDINILYSSQEANLANLRKKQAKNPGKKVNVSARV
                     LSSYIFSSLLMLFMFINIAFRFPFEEMPSFFSTMVAILLVLAFSTSFTAFYNVFYESK
                     DLASYRPYAFKESEIIMAKGLSVLLPALAGIVPILAYFLVLYIRLAPSLWLGLPLMLL
                     SLTLLFVSVTLVMVVAVHFLAQTRVFRKYRSIFSNVMIGIGVLIPLIFIFFLQSTFGS
                     IVDKVRDIPFLLYPLHIFYKIAVEPFSTEALVGLLAWIGLTLFLLYLTKKKVLPRFYD
                     VILLNSEDKVKKERRSKERISTTKKGFFRMVLRYHLTLLGQGTGVVTVLFTSAFFPYL
                     MMIGLISKIRDSQIVPDIHPPYWLPLFFIALFIAVVNNNITSLHSIALSLERENVDFL
                     KSLPFDFARYVKVKFWIIYAVQSFLPVLTLLGLSLYLGLPIISMIYLIVAWILASVIL
                     SCHHYFKDVKNLSTNWSSITDLVNRSNGIVAIVLLFIYSAILMALVIGSIFLVQSLST
                     ILAISLGVGALILLLALAIFGYHYYLSRILAEIEKR"
     gene            complement(26512..27261)
                     /locus_tag="ACL8AS_000192"
     CDS             complement(26512..27261)
                     /locus_tag="ACL8AS_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228133.1"
                     /translation="MIEFQNVSKLYGDKEALSNLNLQIENGEIMGLIGHNGAGKSTTI
                     KSLVSIISPSSGRILVDGQELSENRLAIKRKIGYVADSPDLFLRLTANEFWELIASSY
                     DLSRSDLEASLARLLNVFDFAENRYQVIETLSHGMRQKVFVIGALLSDPDIWVLDEPL
                     TGLDPQAAFDLKQMMKEHAQKGKTVLFSTHVLEVAEQVCNRIAILKKGHLIYCGSVEN
                     LRKDHPDQSLESIYLSLAGRKEEVADASQGH"
     gene            27440..28894
                     /locus_tag="ACL8AS_000193"
     CDS             27440..28894
                     /locus_tag="ACL8AS_000193"
                     /EC_number="3.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004556 - alpha-amylase activity [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-amylase"
                     /protein_id="HGS1228134.1"
                     /translation="MQNQTLMQYFEWYLPHDGQHWTRLAENAPHLAHLGISHVWMPPA
                     FKATNEKDVGYGVYDLFDLGEFNQKGTVRTKYGFKEDYLQAIQALKAQGIQPMADVVL
                     NHKAAADHREAFQVIEVDPVDRTVELGEPFTINGWTSFTFDGRQDTYNGFHWHWYHFT
                     GTDYDAKRSKSGIYLIQGDNKGWANEELVDNENGNYDYLMYADLDFKHPEVIQNIYDW
                     ADWFMETTGVAGFRLDAVKHIDSFFMRNFIRDMKEKYGDDFYVFGEFWNPDKEANLDY
                     LEKTEEHFDLVDVRLHQNLFEASQAGANYDLRGIFTDSLVELKPDKAVTFVDNHDTQR
                     GQALESTVEEWFKPAAYALILLRQDGLPCVFYGDYYGISGQYAQEDFKEILDRLLAIR
                     KDLAYGEQNDYFDHANCIGWVRSGAENQSPIAVLISNDQENSKSMFVGQEWTNQTFVD
                     LLGNHQGQVTIDEEGYGQFPVSARSVSVWAVNTI"
     gene            complement(28984..31602)
                     /gene="alaS"
                     /locus_tag="ACL8AS_000194"
     CDS             complement(28984..31602)
                     /gene="alaS"
                     /locus_tag="ACL8AS_000194"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA];
                     GO_process: GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HGS1228135.1"
                     /translation="MKQLSSAQVRQMWLDFWATKGHSVEPSVSLVPVNDPTLLWINSG
                     VATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRD
                     EAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI
                     GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRS
                     EYKELPHKNIDTGAGLERLVAVTQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMS
                     FKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTV
                     GNIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQ
                     DVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNE
                     TLQNITVESVFNHNASQLSSKLVAIVADNAEVEAVSEGTTSLIFAETPFYAEMGGQVA
                     DHGQILDESGKVVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKN
                     HTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIW
                     EALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGL
                     FKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAIAATLKAPQVKEVPHKVEGLQ
                     EQLRQLQKENAELKEKAAAAAAGDIFKDVKEVNGHRYIASQVSVSDAGALRTFADNWK
                     QKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGS
                     NQAKIQELLDAVAGKL"
     gene            complement(31624..32109)
                     /locus_tag="ACL8AS_000195"
     CDS             complement(31624..32109)
                     /locus_tag="ACL8AS_000195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000847073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LURP-one-related/scramblase family protein"
                     /protein_id="HGS1228136.1"
                     /translation="MKTFLVKQKFRLGGERFAIKDDRGEIAYQVEGSFFKIPKTFTIY
                     DAAGEQVSEISKEILTLLPRFEIQLRDGSSFVIRKKLTFWRDKYEFDNLGLRIEGNIW
                     DLNFKLLDDRDQLIAEIKKELFHLTSTYTVTVLEDAYADLVISLCVAIDYVEMLESQS
                     H"
     gene            complement(32384..32623)
                     /locus_tag="ACL8AS_000196"
     CDS             complement(32384..32623)
                     /locus_tag="ACL8AS_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000784186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228137.1"
                     /translation="MKMSTFFKKSFWPTFMIVNQTAILFHLKDGLDRQYLTTESIYWV
                     IGTFIFGNILVAVFSNMKIWDKKKNGSKKKYILKK"
     gene            complement(32892..33962)
                     /locus_tag="ACL8AS_000197"
     CDS             complement(32892..33962)
                     /locus_tag="ACL8AS_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1228138.1"
                     /translation="MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGD
                     YIDPELLTQFTEETGIQVQYETFDSNEAMYTKIKQGGTTYDIAIPSEYMINKMKDEDL
                     LVPLDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDL
                     WKPEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDLQQLEETVDKLYKLTPNIKAIVAD
                     EMKGYMIQNNVAIGVTFSGEASQMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQNS
                     AYAFINFMLKPENALQNAEYVGYSTPNLPAKELLPEETKEDKAFYPDVETMKHLEVYE
                     KFDHKWTGKYSDLFLQFKMYRK"
     gene            complement(33959..34732)
                     /locus_tag="ACL8AS_000198"
     CDS             complement(33959..34732)
                     /locus_tag="ACL8AS_000198"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228139.1"
                     /translation="MKKFANLYLGLVFLVLYLPIFYLIGYAFNAGDDMNSFTGFSWTH
                     FETMFGDGRLMLILAQTFFLAFLSALIATIIGTFGAIYIYQSRKKYQEAFLSLNNILM
                     VAPDVMIGASFLILFTQLKFSLGFLTVLSSHVAFSIPIVVLMVLPRLKEMNGDMIHAA
                     YDLGASQFQMFKEIMLPYLTPSIITGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYS
                     RARKGISLEINALSALVFLFSIILVVGYYFISREKEEQA"
     gene            complement(34729..35535)
                     /locus_tag="ACL8AS_000199"
     CDS             complement(34729..35535)
                     /locus_tag="ACL8AS_000199"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228140.1"
                     /translation="MKKTSSKLFVVPYMLWIALFVLAPLVLIFGQSFFNIEGQFSLEN
                     YKSYFASQNLTYLKMSFNSVLYAGIVTFVTLLISYPTALFLTRLKHRQLWLMLIILPT
                     WINLLLKAYAFIGIFGQNGSINQFLEFIGIGSQQLLFTDFSFIFVASYIELPFMILPI
                     FNVLDDMDNNLINASYDLGATKWETFRHVIFPLSMNGVRSGVQSVFIPSLSLFMLTRL
                     IGGNRVITLGTAIEQNFLTNDNYGMGSTIGVILILTMFITMWVTKERRER"
     gene            complement(35516..36673)
                     /locus_tag="ACL8AS_000200"
     CDS             complement(35516..36673)
                     /locus_tag="ACL8AS_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018372333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228141.1"
                     /translation="MKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGS
                     GKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVHTVFQSYALFPHMNVFENVAF
                     PLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVL
                     LDEPLSALDLKLRTDMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQ
                     SGTPVDIYDEPINHFVATFIGESNILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEV
                     VIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIVGEEIG
                     LDFESEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKL"
     gene            complement(36731..37681)
                     /gene="murB"
                     /locus_tag="ACL8AS_000201"
     CDS             complement(36731..37681)
                     /gene="murB"
                     /locus_tag="ACL8AS_000201"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000116191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008762 - UDP-N-acetylmuramate
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HGS1228142.1"
                     /translation="MSVREKMLEILEGIDIRFQEPLHSYSYTKVGGEADYLVFPRNRF
                     ELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGA
                     NLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEI
                     ETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEY
                     PSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQ
                     SVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR"
     gene            complement(37793..38546)
                     /locus_tag="ACL8AS_000202"
                     /pseudo
     CDS             complement(37793..38546)
                     /locus_tag="ACL8AS_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152219.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhfC family intramembrane metalloprotease"
     gene            complement(38556..39287)
                     /gene="budA"
                     /locus_tag="ACL8AS_000203"
     CDS             complement(38556..39287)
                     /gene="budA"
                     /locus_tag="ACL8AS_000203"
                     /EC_number="4.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047605 - acetolactate decarboxylase
                     activity [Evidence IEA];
                     GO_process: GO:0045151 - acetoin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate decarboxylase"
                     /protein_id="HGS1228143.1"
                     /translation="MDKNVQEPVKLFQYNTLGALMAGLYGGTMTVGELLEHGDLGLGT
                     LDSIDGELIVLDGKAYQAKGTGEQPEIVEVSPDALIPYAAVVPHQAEVIFRQRFEMTD
                     KELEERIESYYDGENLFRSIKIRGEFSHMHVRMIPKSTPDTKFADVATHQPEYSRDNV
                     AGTIVGFWTPEIFHGVSVAGYHLHFISDDLTFGGHVMDFVIKEGIIEVGAVDQLDQRF
                     PVQDRQYLFAKFNVDEMKKDIEKAE"
     gene            39429..40700
                     /locus_tag="ACL8AS_000204"
     CDS             39429..40700
                     /locus_tag="ACL8AS_000204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HGS1228144.1"
                     /translation="MKRQSKYKEVVSYLKNGIESGRFPTGSRLPSIRQLSLDFHCSKD
                     TIQRALLELRHEQYLYAKPQSGYYVLEQGQHQDLEIEVTDEHASAYDDFRLCVNETLI
                     GRENYLFNYYDNQEGLEGLRQSIHKLLFEQALYCKANQLVLTSGTQQALFILSQISFP
                     RQAKEILVEQPTYHRMNRLLIAQGLDYQTIERGIDGIDLEELEGHFKTGKIKFFYTIP
                     RFHYPLGHSYSEQDKRSILNLAAKYDVYIVEDDYLGDLDSKKGQTFHYLDTEERVIYI
                     KSFSTSLFPALRITALILPNAIKEAFMAYKNILDYDSNLIMQKALSLYIDSQLFEKNR
                     LARLTNHESYQKQIEERITKTPCPLPHYPLHDGLLLDLRQYPKIASLKHSQLGLDFFE
                     EAYLSTCPYQFAKVSLDNLENVLNYLKAELE"
     gene            complement(40720..41535)
                     /locus_tag="ACL8AS_000205"
     CDS             complement(40720..41535)
                     /locus_tag="ACL8AS_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1228145.1"
                     /translation="MKSKKWIFVLCNFLASFFLVACQSGSNGSQSAVEAIKQKGKLVV
                     ATSPDYAPFEFQSLVDGKNQVVGADIDMAQAIADELGVKLEILSMSFDNVLTSLQTGK
                     ADLAVAGISATDERKEVFDFSIPYYENKISFLVRKADVEKYKDLTSLESANIAAQKGT
                     VPESMVKEQLPKAQLTSLTNMGEAVNELQAGKIDAVHMDEPVALSYAAKNAGLAVATV
                     SLKMKDGDANAVALRKNSDDLKEVVDKVIQKLKDEGTYQSYLEKAASLTEVEE"
     gene            complement(41692..42345)
                     /gene="phoU"
                     /locus_tag="ACL8AS_000206"
     CDS             complement(41692..42345)
                     /gene="phoU"
                     /locus_tag="ACL8AS_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000946475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA];
                     GO_process: GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA];
                     GO_process: GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HGS1228146.1"
                     /translation="MLRSQFEEDLEKLHNQFYAMGQEVLSQINRTVRAFVTHDRDLAK
                     EVIEDDAEVNEYEVKLEKKSFEMIALQQPVSQDLRTVLTVLKAVSDVERMGDHAVAIA
                     QATIRMKGEERIPAVEEEIKKMGREVKSVVEAALDLYLNGSVDDAYRVASMDEQINHY
                     FETIRDLATEEIKKNPEAIVTGRDYFQVISYLERIGDYAKNICEWVVYFETGKIVEL"
     gene            complement(42357..43115)
                     /gene="pstB"
                     /locus_tag="ACL8AS_000207"
     CDS             complement(42357..43115)
                     /gene="pstB"
                     /locus_tag="ACL8AS_000207"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="HGS1228147.1"
                     /translation="MTDAILQVSDLSVYYNKKKALNSVSLSFQPKEITALIGPSGSGK
                     STLLKSLNRMGDLNPEVTTTGSVVYNGHNIYSPRTDTVELRKEIGMVFQQPNPFPMTI
                     YENVVYGLRINGIKDKQVLDEAVEKALQGASIWDEVKDRLYDSAIGLSGGQQQRVCVA
                     RVLATSPKIILLDEPTSALDPISAGKIEETLYGLKDKYTMLLVTRSMQQASRISDKTG
                     FFLDGDLIEFNDTKQMFLDPQHKETEDYITGKFG"
     gene            complement(43128..43931)
                     /gene="pstB"
                     /locus_tag="ACL8AS_000208"
     CDS             complement(43128..43931)
                     /gene="pstB"
                     /locus_tag="ACL8AS_000208"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="HGS1228148.1"
                     /translation="MSTYNWDEKHILTFPEEKVALSTKDVHVYYGKNESIKGIDMQFE
                     RNKITALIGPSGSGKSTYLRSLNRMNDTIDIAKVTGQILYRGIDVNRPEINVYEMRKH
                     IGMVFQRPNPFAKSIYRNITFAHERAGVKDKQVLDEIVETSLRQAALWDQVKDDLHKS
                     ALTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKNFTIIIV
                     THNMQQAARASDYTGFFYLGDLIEYDKTATIFQNAKLQSTNDYVSGHFG"
     gene            complement(43942..44826)
                     /gene="pstA"
                     /locus_tag="ACL8AS_000209"
     CDS             complement(43942..44826)
                     /gene="pstA"
                     /locus_tag="ACL8AS_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009443446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HGS1228149.1"
                     /translation="MRAKKLDKLATAVLYTIASIIVTILASLILYILVRGLPHISWSF
                     LTGRSSAFQAGGGIGIQLYNSFFLLVITLIISVPLSMGAGIYLAEYAKKGPVTNFVRT
                     CIEILSSLPSVVVGLFGYLIFVVQFEYGFSIISGALALTVFNLPQMTRNVEDSLKHVH
                     HTQREAGLALGISRWETVVHVVIPEALPGIVTGVVLASGRIFGEAAALIYTAGQSAPA
                     LDWSNWNILSVTSPISIFRQAETLAVHIWKVNSEGTIPDGTIVSAGSAAVLLIFILIF
                     NFGARKFGSYLHKKLTAA"
     gene            complement(44816..45733)
                     /gene="pstC"
                     /locus_tag="ACL8AS_000210"
     CDS             complement(44816..45733)
                     /gene="pstC"
                     /locus_tag="ACL8AS_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018378778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HGS1228150.1"
                     /translation="MNQEELAKKMLLPSKNSRLEKLGKGLTFACLSLIVILVAMILVF
                     VAQKGLSTFFVNGVNIFDFLLGGTWNPSSKEFGALPMILGSFIVTILSALIATPFAIG
                     AAVFMTEVSPKGAKILQPAIELLVGIPSVVYGFIGLQVVVPFVRSVFGGTGFGILSGI
                     SVLFVMILPTVTFMTTDSLRAVPRYYREASFAMGATRWQTIWRVILKAARSGIFTAVV
                     FGMARAFGEALAIQMVVGNSAVIPTSLTTPAATLTSILTMGIGNTVMGTVNNNVLWSL
                     ALVLLLMSLVFNSVIKLITKERGKKNYAR"
     gene            complement(45733..46611)
                     /gene="pstS"
                     /locus_tag="ACL8AS_000211"
     CDS             complement(45733..46611)
                     /gene="pstS"
                     /locus_tag="ACL8AS_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein PstS"
                     /protein_id="HGS1228151.1"
                     /translation="MKKRKKLALSLIAFWLTACLVGCASWIDRGESITAVGSTALQPL
                     VEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQSGAVDIGNSDVFAEEKDGIDASALVD
                     HKVAVAGLALIVNKEVDVDNLTTEQLRQIFIGEVTNWKEVGGKDLPISVINRAAGSGS
                     RATFDTVIMEGQSAMQSQEQDSNGAVKSIVSKSPGAISYLSLTYIDDSVKSMKLNGYD
                     LSPENISSNNWPLWSYEHMYTLGQPNELAAEFLNFVLSDETQEGIVKGLKYIPIKEMK
                     VEKDAAGTVTVLEGRQ"
     gene            complement(47185..48489)
                     /locus_tag="ACL8AS_000212"
     CDS             complement(47185..48489)
                     /locus_tag="ACL8AS_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmF rRNA methyltransferase first C-terminal
                     domain-containing protein"
                     /protein_id="HGS1228152.1"
                     /translation="MQFPEGFVEKYKEILGDEARNFLASFEEEAVSAFRVNPLKEEQL
                     SFSDAITQTPWGHYGKVSGKSPEHATGLVYSQEPAAQMVAQVAQPSPGMKVLDLAAAP
                     GGKSTQLAAYLAGEGLLVSNEISSKRAKILVENMERFGATNVVVTNESADRLVKVFKG
                     YFDLIVLDAPCSGEGMFRKQPDAMDYWSLDYPSQCASLQREILEDAVTMLAEGGRLVY
                     STCTWAPEENEEIVNWLLEEYDFDLLPVEHINGMVAGIDLPETARMYPHQFKGEGQFV
                     AHLQFKGNNPAPKFKASKSNLSREQVALWQEFAQNHLKVNLPGILQTFGDQLYLLPEL
                     LPDLGKLKIARNGLHLGTFKKKRFEPSFALGLALKPSQVEQSVEIGQEAFVKYAAGEI
                     VQLAESLPNGWYQVLVKGNGLGFAKVTGNVLKNYFPKGLRFK"
     gene            complement(48490..49263)
                     /locus_tag="ACL8AS_000213"
     CDS             complement(48490..49263)
                     /locus_tag="ACL8AS_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="inositol monophosphatase family protein"
                     /protein_id="HGS1228153.1"
                     /translation="MESKFEFAKELVKKAGQYILDHMQEDLRVETKSSPTDLVTRLDK
                     EVQELLVGEILSRYPEDKICAEEGCLRASVQEGKVWVIDPIDGTNNFVAQQEDFAVMM
                     AYFENGQGQFGLIYDVVKGDCYHGGGEFPVCLNDRPLAPFKTKPLGDFLIAGNSGMLE
                     TNEWGLADLSRAVLGVRVYGSAAISFAKILSGHLLTYLTYLQPWDYAAASILGESLGY
                     RVVTLFGEAPDFQTRQPVMMVPLEMQEEIQSYIYERKRT"
     gene            complement(49253..49531)
                     /locus_tag="ACL8AS_000214"
     CDS             complement(49253..49531)
                     /locus_tag="ACL8AS_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0223 family protein"
                     /protein_id="HGS1228154.1"
                     /translation="MNKQYSYPLDLSWSTEELASVLSFFNDVEAAYEGKVEAKKLLDS
                     YKGFKAVVPSKSEEKRLGREFETVSGYSLYRAVQAAKEKGEGKISLGK"
     gene            complement(49531..49932)
                     /locus_tag="ACL8AS_000215"
     CDS             complement(49531..49932)
                     /locus_tag="ACL8AS_000215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007556665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spx/MgsR family RNA polymerase-binding
                     regulatory protein"
                     /protein_id="HGS1228155.1"
                     /translation="MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQH
                     ILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSILRRPIIIDAKRMQ
                     IGFNEDEIRAFLPRSYRKQELKEARMRAGIS"
     gene            complement(50142..50759)
                     /locus_tag="ACL8AS_000216"
     CDS             complement(50142..50759)
                     /locus_tag="ACL8AS_000216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HGS1228156.1"
                     /translation="MKTKLTFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVY
                     LKPETIQYNFHILMNYLTNPFSQVLQMPDFRSSAAGLHHFAVVKNLFHLVQLVALVTL
                     PSFYVFVNRIVKKDFLSLYRKSLLALVVLPVMIGLGGVLIGFDQFFTLFHQILFVGDD
                     TWLFDPAKDPVIMILPETFFLHAFLLFFALYENFFGYLYLKSRRK"
     gene            complement(50749..51522)
                     /locus_tag="ACL8AS_000217"
     CDS             complement(50749..51522)
                     /locus_tag="ACL8AS_000217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01457 family HAD-type hydrolase"
                     /protein_id="HGS1228157.1"
                     /translation="MKYKGYLIDLDGTIYKGKDRIPAGETFVHELQKRDIPYLFVTNN
                     TTRTPESVKEMLAQNFNIDTPLSTVYTATLATIDYMNDLGLEKTVYVVGEAGLKEAIK
                     AAGYVEDKENPAYVVVGLDWQVDYEKFATATLAIQKGAHFIGTNPDLNIPTERGLLPG
                     AGSLIMLLEVATRVKPVYIGKPNAIIMDKAVEHLGLEREELIMVGDNYLTDIWAGIDN
                     GIPTLLVTTGFTKAEEVAGLPIAPTHVVSSLAEWDFDEN"
     gene            complement(51533..52270)
                     /locus_tag="ACL8AS_000218"
     CDS             complement(51533..52270)
                     /locus_tag="ACL8AS_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000524807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-ACP thioesterase domain-containing protein"
                     /protein_id="HGS1228158.1"
                     /translation="MGLTYQMKMKIPFDMADMNGHIKLPDVILLSLQVSGMQSIELGV
                     SDKAILEDYNLVWIIAEYDIEVVRLPRFAEEITIETEALSYNRLFCYRCFTIYNEAGQ
                     ELIHMMATFVLMDRDSRKVHAVEPEIVAPYQSDFDKKLIRGPKYESLEELISKDYHVR
                     FYDLDMNGHVNNSKYLDWIFEVMGADFLTHYIPKKINLKYVKEVRPGGVITSAVERTG
                     LESKHEITSDGVINAQAIITWQEIKEA"
     gene            complement(52275..53405)
                     /gene="hemW"
                     /locus_tag="ACL8AS_000219"
     CDS             complement(52275..53405)
                     /gene="hemW"
                     /locus_tag="ACL8AS_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM family heme chaperone HemW"
                     /protein_id="HGS1228159.1"
                     /translation="MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEE
                     FRSYDIEKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLDAD
                     KIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAGFDNISIDLIY
                     ALPGQTMEQVKENVAKAIELDIPHMSLYSLILENHTVFMNRMRRGKLPLPKEELEAEM
                     FEYIIAELERAGFEHYEISNFSKPGFESRHNLMYWDNAEYYGIGAGASGYVNGVRYKN
                     HGPIRHYLSAVEEGNACITEDHLSQKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAG
                     LYGEIVRDLVQQGLMQIEGDHVRMTKRGLFLGDTVAERFILE"
     gene            complement(53489..53878)
                     /locus_tag="ACL8AS_000220"
     CDS             complement(53489..53878)
                     /locus_tag="ACL8AS_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HGS1228160.1"
                     /translation="MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDP
                     EYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEITVDSILAQAKSYAFQATEASKNQL
                     NNLKEQWQEKAEALDDSEEIVIDITEE"
     gene            complement(53851..54277)
                     /locus_tag="ACL8AS_000221"
                     /pseudo
     CDS             complement(53851..54277)
                     /locus_tag="ACL8AS_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895042.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
     gene            complement(54278..55066)
                     /gene="lgt"
                     /locus_tag="ACL8AS_000222"
     CDS             complement(54278..55066)
                     /gene="lgt"
                     /locus_tag="ACL8AS_000222"
                     /EC_number="2.5.1.145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008961 -
                     phosphatidylglycerol-prolipoprotein diacylglyceryl
                     transferase activity [Evidence IEA];
                     GO_process: GO:0009249 - protein lipoylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HGS1228161.1"
                     /translation="MLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPD
                     DILDFILVAFPLAILGARLYYVIFRFDYYSQNLGEIFAIWNGGLAIYGGLITGALVLY
                     IFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQMY
                     IEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMR
                     TDSLMFFGLRVSQWLSVVLIGLGIMIVIYQNRKKAPYYITEEEN"
     gene            complement(55059..55994)
                     /gene="hprK"
                     /locus_tag="ACL8AS_000223"
     CDS             complement(55059..55994)
                     /gene="hprK"
                     /locus_tag="ACL8AS_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006109 - regulation of carbohydrate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HPr(Ser) kinase/phosphatase"
                     /protein_id="HGS1228162.1"
                     /translation="MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYF
                     DYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAA
                     RECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKS
                     ETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGAS
                     AVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIE
                     AAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA"
     gene            complement(56124..56300)
                     /gene="rpsU"
                     /locus_tag="ACL8AS_000224"
     CDS             complement(56124..56300)
                     /gene="rpsU"
                     /locus_tag="ACL8AS_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HGS1228163.1"
                     /translation="MSKTVVRKNESLDDALRRFKRAVTKAGTLQETRKREFYEKPSVK
                     RKRKSEVARKRKKF"
     gene            complement(56440..57147)
                     /locus_tag="ACL8AS_000225"
     CDS             complement(56440..57147)
                     /locus_tag="ACL8AS_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HGS1228164.1"
                     /translation="MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYK
                     EIVESDLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNA
                     EAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARF
                     FAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNH
                     PDVTIIADAEALSLLEK"
     gene            57298..58326
                     /gene="queA"
                     /locus_tag="ACL8AS_000226"
     CDS             57298..58326
                     /gene="queA"
                     /locus_tag="ACL8AS_000226"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_function: GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HGS1228165.1"
                     /translation="MNTADFDFHLPEELIAQTPLEKRDASKLLIVNRETGEMQDKHFH
                     SIIDMLEPGDALVMNDTRVLPARLYGQKVETGGHVELLLLKNTSGDEWEVLAKPAKRL
                     KVGTRISFGDGRLSAVVTEELTHGGRIVRFEYQGIFLEVLESLGEMPLPPYIHEKLDD
                     RERYQTVYAKESGSAAAPTAGLHFTKELLAEIQAKGVHLVYLTLHVGLGTFRPVSVDN
                     LDEHEMHSEFYQLSEEAAATLRSVKENGGRVIAVGTTSIRTLETIGSKFDGQIQADSG
                     WTNIFIKPGYEWKVVDAFSTNFHLPKSTLVMLVSAFAGRELVLDAYHHAIQEHYRFFS
                     FGDAMFIY"
     gene            complement(58987..59376)
                     /locus_tag="ACL8AS_000227"
     CDS             complement(58987..59376)
                     /locus_tag="ACL8AS_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HGS1228166.1"
                     /translation="MVKRRIRRGTREPEKVVVPEQSSIPSYPVSVTSNQGTDVAVEPA
                     KAVAPTTGWKQENGMWYFYNIDGSMATGWVQVNDSWYYLNSNGSMKVNQWFQVGGKWY
                     YVNTSGELAVNTSIDGYRVNDNGEWVR"
     gene            complement(59430..60137)
                     /locus_tag="ACL8AS_000228"
     CDS             complement(59430..60137)
                     /locus_tag="ACL8AS_000228"
                     /inference="COORDINATES: protein motif:HMM:NF019142.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HGS1228167.1"
                     /translation="MFRRNLNTSFVHAADGIQYVRDDTRDKEEGIEYDDADNGDIIVK
                     VATKPKVVTKKISSTRIRYEKDETKDRSENPVTIDGEDGYVTTTRTYDVNPETGHVTE
                     QVTVDRKEATDTVIKVPAKSKVEEVLVPFATKYEADNDLSAGQEQEITLGKNGKTVTT
                     ITYDVDGKSGQVTESTLSQKEDSQTRVVKKGTKPQVLVQEIPIETEYLDGPTLDKSQE
                     VEEVGEIGKLLLLQSIL"
     gene            complement(60837..61388)
                     /locus_tag="ACL8AS_000229"
     CDS             complement(60837..61388)
                     /locus_tag="ACL8AS_000229"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228168.1"
                     /translation="MKSIGTQILQTERLILRRFVESDAEAMFQNWASSAENLTYVTWD
                     PHPDVEITRNSIRNWVASYTNLNYYKWAICLKENPEQVIGDISIVKIDEADLSCEIGY
                     VLGKAYWGHGMMTEALKAVLDFCFTQAGFQKVRARYASLNPASGRVMEKAGMSYLQTI
                     VNGVERKGYLADLIYYGISREEC"
     gene            complement(61738..62562)
                     /gene="nadE"
                     /locus_tag="ACL8AS_000230"
     CDS             complement(61738..62562)
                     /gene="nadE"
                     /locus_tag="ACL8AS_000230"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003952 - NAD+ synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_function: GO:0004359 - glutaminase activity [Evidence
                     IEA];
                     GO_function: GO:0008795 - NAD+ synthase activity [Evidence
                     IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ammonia-dependent NAD(+) synthetase"
                     /protein_id="HGS1228169.1"
                     /translation="MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFV
                     LGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQ
                     PDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGFHSGAVIGT
                     DHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLEEDK
                     PGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE"
     gene            complement(62559..64019)
                     /locus_tag="ACL8AS_000231"
     CDS             complement(62559..64019)
                     /locus_tag="ACL8AS_000231"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004516 - nicotinate
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HGS1228170.1"
                     /translation="MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFK
                     NGYAVFAGLERIVNYLEGLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGD
                     LVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
                     AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYA
                     ATHKNCVFLVDTYDTLRIGVPAAIQVARELGDQINFMGVRIDSGDIAYISKKVRQQLD
                     EAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIE
                     DENGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKM
                     FHPTYTYIKKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRV
                     LNPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE"
     gene            complement(64135..64623)
                     /locus_tag="ACL8AS_000232"
     CDS             complement(64135..64623)
                     /locus_tag="ACL8AS_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6773 family protein"
                     /protein_id="HGS1228171.1"
                     /translation="MKNRFYYYQLLDEREEQLFNKAGSESLYICIALSLLSYIISVLA
                     PSLFNSNMLLIVIIIGTFYFFNRARYLGVTYYSRFHFTILGCFFLTLAITALLMLQNY
                     QFNIEIYQHNPLNFKYLSAWVITYVIYLPWVFIGNLGLKSYGEWAQKKFEQDMDELES
                     GE"
     gene            complement(64613..64822)
                     /locus_tag="ACL8AS_000233"
     CDS             complement(64613..64822)
                     /locus_tag="ACL8AS_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HGS1228172.1"
                     /translation="MAKNLKLKLARVERDLTQGQLAEAVGVTRQTIGLIEAGKYNPSL
                     SLCQSICRCLGKTLDQLFWEEEDEK"
     gene            complement(65207..65935)
                     /locus_tag="ACL8AS_000234"
     CDS             complement(65207..65935)
                     /locus_tag="ACL8AS_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228173.1"
                     /translation="MKLNKLNFLKENIRNLYSSGVIYLSLLISFIPPILLTFFILKTQ
                     GTSLGIKHISNFYAMLGMLMAVIHANRVISRDFSHNTVSLFYNQQKNRMIYVLSNFLY
                     AISVSIIYALNGIVLLVIVSKLGIPGDLGLDFIVAIVVNTILLVLFYFLLSYIFYLYK
                     LKSGLVFGILVALLLFIPNILNTMMMNTSNDLFIKAIELLPFYSLPLFVASNTMSISQ
                     YLVLITTIILLYFFTLKKSKKYSF"
     gene            complement(65951..66822)
                     /locus_tag="ACL8AS_000235"
                     /pseudo
     CDS             complement(65951..66822)
                     /locus_tag="ACL8AS_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220488.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
     gene            complement(67179..67907)
                     /locus_tag="ACL8AS_000236"
                     /pseudo
     CDS             complement(67179..67907)
                     /locus_tag="ACL8AS_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase C-terminal
                     domain-containing protein"
     gene            complement(68167..68478)
                     /locus_tag="ACL8AS_000237"
     CDS             complement(68167..68478)
                     /locus_tag="ACL8AS_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CHY zinc finger protein"
                     /protein_id="HGS1228174.1"
                     /translation="MIEAQGFLVDKQTRCIHYHSKLDIIALQCYDCKKYYACYRCHDS
                     LENHPFEPYPLSLIQDKPILCGVCLKLLTYKQYKESLSCLFCFSRFNPGCQNHKERYF
                     K"
     gene            complement(68493..69779)
                     /locus_tag="ACL8AS_000238"
     CDS             complement(68493..69779)
                     /locus_tag="ACL8AS_000238"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:1901576 - obsolete organic substance
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HGS1228175.1"
                     /translation="MTKTLKRPEVLSPAGTLEKLKVAVQYGADAVFIGGQAYGLRSRA
                     GNFTFEQMEEGVQFAAKYGAKVYVAANMVMHEGNEAGAGEWFRKLRDIGIAAVIVSDP
                     ALIMIAATEAPGLEIHLSTQASATNYETLEFWKELGLTRVVLAREVSMEELAEIRKRT
                     DVEIEAFVHGAMCISYSGRCTLSNHMSMRDANRGGCSQSCRWKYDLYDMPFGKERKSL
                     QGEIPEEFSMSAVDMSMIDHIPDMIENGVDSLKIEGRMKSIHYVSTVTNCYKAAVDAY
                     LESPEKFEAIKQDLVDEMWKVAQRELATGFYYGIPSENEQLFGARRKIPEYKFVAEVV
                     SYDDAVQTATIRQRNVINEGDQVEFYGPGFRHFETYIEDLHDAKGNKIDRAPNPMELL
                     TIKVPQPVQSGDMVRALKEGLINFYKEDGTSVTVRA"
     gene            70376..70957
                     /locus_tag="ACL8AS_000239"
                     /pseudo
     CDS             70376..70957
                     /locus_tag="ACL8AS_000239"
                     /inference="COORDINATES: protein motif:HMM:NF021048.4"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ApaLI family restriction endonuclease"
     gene            70954..72144
                     /locus_tag="ACL8AS_000240"
     CDS             70954..72144
                     /locus_tag="ACL8AS_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific DNA-methyltransferase"
                     /protein_id="HGS1228176.1"
                     /translation="MTVLKGDNLEILKTIESSSIDLIYMDPPFFTQKTQKLSNNKNIM
                     YSFEDTWTSIEDYKEFLSVRLEECKRVLKNSGSIFVHCDKIANHHIRLILDNIFGADM
                     FQSEIIWNYKRWSNSKKGLLNNHQNIYFYSKSKDFKFNTIFTEYSSTTNIDQILVERK
                     RDGNSKTIYKVDNNGNYILAKEKNGVPLSDVWNIPFLNPKAKERVGYPTQKPILLLEQ
                     IIKIATDKNDIVLDPFCGSGTTLVASKILNRNYMGIDLSEEAINITQQRLENVIKTSS
                     NLLNKGIEAYRTKTEEEENILKLLQAKIVQRNKGIDGFLPKHFQKKPIPIKIQKNNEC
                     LNESISLLQNAINSKKLDFGVVIKTHSDNLLFDFDTIPENIIVVDHFELTIEKWLSKS
                     QQLL"
     gene            complement(72220..73782)
                     /gene="guaA"
                     /locus_tag="ACL8AS_000241"
     CDS             complement(72220..73782)
                     /gene="guaA"
                     /locus_tag="ACL8AS_000241"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003922 - GMP synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016462 - pyrophosphatase activity
                     [Evidence IEA];
                     GO_process: GO:0006177 - GMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HGS1228177.1"
                     /translation="MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHK
                     ISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGG
                     KVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
                     CPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKK
                     IRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLG
                     GKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGT
                     LYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHI
                     VWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVR
                     SVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYD
                     ITSKPPATVEWE"
     gene            73924..74622
                     /locus_tag="ACL8AS_000242"
     CDS             73924..74622
                     /locus_tag="ACL8AS_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000936186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HGS1228178.1"
                     /translation="MLPAYMKIHDQIKKDIDEHRWAIGERLPSERDLAEQFAVSRMTL
                     RQAVSLLVEEGVLERRVGSGTFVSSTRVQEKMRGTTSFTEIVKSQGKVPSSQLISYKK
                     TIPNEQEVAKLGIFPTDNIIRMERVRYADQVPLVYEVASIPEKFIKDFKKEEITSHFF
                     QTLQKHGYRIGKSQQTIYARLAKEKIAHYLEVEKGHAILGLTQISYLEDGTAFEYVKS
                     QYVGERFEFYLENN"
     gene            complement(74665..75561)
                     /locus_tag="ACL8AS_000243"
     CDS             complement(74665..75561)
                     /locus_tag="ACL8AS_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HGS1228179.1"
                     /translation="MSNSLKGTLLTVVAGIAWGLSGTSGQYLMAHGISALVLTNLRLL
                     IAGGILMLLAYATTKDKILVFLKDRKSLLSLLIFALIGLFLNQFAYLSAIQETNAGTA
                     TVLQYVCPVGILIYSCIKDRVAPTLGEIVSIILAIGGTFLIATHGQLDQLSMTPAGLF
                     WGLFSALTYALYIILPIALIKKWGSSLVIGVGMVIAGLVALPFTGVLQADIPTSLDFL
                     LAFAGIILIGTVFAYTAFLKGASLIGPVKSSLLASIEPISAIFFAFLIMNEQFYPIDF
                     LGMAMILFAVTLISLKDLFLEK"
     gene            complement(75570..76505)
                     /locus_tag="ACL8AS_000244"
     CDS             complement(75570..76505)
                     /locus_tag="ACL8AS_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="HGS1228180.1"
                     /translation="MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSAPEH
                     GLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLDIDRLVIDFLPESDYPDITIRQLL
                     THATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDL
                     DVILKDQVWKPWGMTETKVGPVELAVPTVRGVEAGIVHDPKARLLGRHAGSAGLFSTI
                     KDLQIFLEHYLADDFARDLNQNFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQK
                     QEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEE"
     gene            complement(76502..77227)
                     /locus_tag="ACL8AS_000245"
     CDS             complement(76502..77227)
                     /locus_tag="ACL8AS_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001102210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CppA family protein"
                     /protein_id="HGS1228181.1"
                     /translation="MNVNQIVRIIPTLKANNRKLNETFYIETLGMKALLEESAFLSLG
                     DQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVENPLEIEGILSKTDSIHRLYKGQN
                     GYAFEIFSPEDDLILIHAEDDRASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDI
                     ESFLESSEIGASLDFIPAQGQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFESTEYF
                     IPKSEKFFLGKDRNNVELWFEEV"
     gene            complement(77311..77946)
                     /locus_tag="ACL8AS_000246"
     CDS             complement(77311..77946)
                     /locus_tag="ACL8AS_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="HGS1228182.1"
                     /translation="MAVQLLENWLLKEQEKIQTKYRHLNHISVVEPNILFIGDSIVEY
                     YPLQELFGTSKTIVNRGIRGYQTGLLLENLDAHLYGGAVDKIFLLIGTNDIGKDVPVN
                     EALNNLEAIIQSVARDYPLTEIKLLSILPVNEGEKYQQAVYIRSNEKIQNWNQAYQEL
                     ASAYMQVEFVPVFDCLTDQAGQLKKEYTTDGLHLSIAGYQALSKALKDYLY"
     gene            complement(77948..78775)
                     /locus_tag="ACL8AS_000247"
     CDS             complement(77948..78775)
                     /locus_tag="ACL8AS_000247"
                     /EC_number="3.-.-.-"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HGS1228183.1"
                     /translation="MMIKVIATDMDGTLLDARGQLDLPRLEKILDQLDQRGIRFVIAT
                     GNEIHRMRQLLSPLVDRVVLVVANGARIFENNELIQAQTWDDAIVNKALAHFKGRACQ
                     DQFVVTGMKGDFVKEGTIFTDLESFMTPEMIEKFYQRMQFVDELTSDLFGGVLKMSMV
                     VGEERLSSVLEEINTLFDGRVRAVSSGYGCIDILQAGIHKAWGLEELLKRWDLKSQAI
                     MAFGDSENDVEMLEMAGIAYAMENADEKAKAVATALAPANSQGGVYQVLENWLEKGE"
     gene            complement(78797..79133)
                     /locus_tag="ACL8AS_000248"
                     /pseudo
     CDS             complement(78797..79133)
                     /locus_tag="ACL8AS_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398793.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="poly-gamma-glutamate biosynthesis protein"
     gene            complement(79134..79850)
                     /locus_tag="ACL8AS_000249"
     CDS             complement(79134..79850)
                     /locus_tag="ACL8AS_000249"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: protein motif:HMM:NF021127.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HGS1228184.1"
                     /translation="MAHGDLLYHDGLFFSAKKEDGTYDFHENFEYVTPWFKQADLAIG
                     DFEETINKDHYLAGYPLFNAPAEVMDAIKEAGYHVLDLAHNHILDSQIEGVISTADII
                     EKAGITPIGVYTHEPRDQAPLVIKEVNGIKVALLAYSYGFNGIEQYISQEDYNRYLSD
                     LNEDKIKAEVERAEKEADITIIMPQMGVEYRLEPTEEQKALYHKMIDWGADIIFGGYP
                     HVVEPSETVEKDGDKKLIVY"
     gene            80363..80974
                     /gene="def"
                     /locus_tag="ACL8AS_000250"
     CDS             80363..80974
                     /gene="def"
                     /locus_tag="ACL8AS_000250"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042586 - peptide deformylase activity
                     [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HGS1228185.1"
                     /translation="MSAIERITKAAHLIDMNDIIREGNPTLRAIAEKVTFPLSDQEII
                     LGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEA
                     YDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
                     IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE"
     gene            81019..81747
                     /gene="rlmB"
                     /locus_tag="ACL8AS_000251"
     CDS             81019..81747
                     /gene="rlmB"
                     /locus_tag="ACL8AS_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HGS1228186.1"
                     /translation="MKTNDIVYGVHAVTEALLANTGNKLYLQEDLRGKNVEKVKELAT
                     EKKVSISWTSKKSLSEMTEGAVHQGFVLRVSEFAYSELDYILAKTRQEENPLLLILDG
                     LTDPHNLGSILRTADATNVSGVIIPKHRTVGVTPVVAKTATGAIEHVPIARVTNLSQT
                     LDKLKDEGFWTFGTDMNGTPCHKWNTKGKIALIIGNEGKGISSNIKKQVDEMITIPMN
                     GHVQSLNASVAAAILMYEVFRNRL"
     gene            complement(81786..82697)
                     /gene="trxB"
                     /locus_tag="ACL8AS_000252"
     CDS             complement(81786..82697)
                     /gene="trxB"
                     /locus_tag="ACL8AS_000252"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004791 - thioredoxin-disulfide reductase
                     (NADPH) activity [Evidence IEA];
                     GO_function: GO:0071949 - FAD binding [Evidence IEA];
                     GO_process: GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HGS1228187.1"
                     /translation="MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSD
                     IENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRT
                     VIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEALFLT
                     RFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKT
                     GQVTEQAFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDNHMKTAVDGIFAVGDVRLK
                     DLRQVTTAVGDGAIAGQEAYKFITEHS"
     gene            complement(82763..82987)
                     /locus_tag="ACL8AS_000253"
     CDS             complement(82763..82987)
                     /locus_tag="ACL8AS_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4059 family protein"
                     /protein_id="HGS1228188.1"
                     /translation="MLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTARARQ
                     AHLYDMIMIGVLVVPVLSFAVMSLILVFKA"
     gene            complement(83065..83808)
                     /locus_tag="ACL8AS_000254"
     CDS             complement(83065..83808)
                     /locus_tag="ACL8AS_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HGS1228189.1"
                     /translation="MIKISNLSKSFSGQTVLDHLDLDIQKGEVVALIGSSGAGKSTFL
                     RSLNYLETPDSGSIQIDGFSVDFSKITQEEILALRRKLSMVFQQFNLFERRTALDNVK
                     EGLVVVKKLSDQEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDV
                     LLLDEPTSALDPELVGEVEKSIADAAKSGQTMILVSHDMPFVAQVADKILFLDKGKII
                     ESGTPDEIIHTPKEERTKEFFASYKRTYI"
     gene            complement(83808..84608)
                     /locus_tag="ACL8AS_000255"
     CDS             complement(83808..84608)
                     /locus_tag="ACL8AS_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001103446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HGS1228190.1"
                     /translation="MNVTTILASDWYQNLMQLIPDGKLFSLRSVFDGIPRIVQQLPTT
                     IMLTIGGALFGLVLALLFAIVKINRVKILYPLQAFFVSFLKGTPILVQLMLTYYGIPL
                     ALKALNQQWGTGLNINAIPAAAFAIVAFAFNEAAYASETIRAAILSVNPGEIEAARSL
                     GMTRAQVYRRVIIPNAAVVATPTLINSLIGLTKGTSLAFSAGVVEVFAQAQILGGADY
                     RYFERFISVALVYWVVNIGIESLGRFIERKMAISAPDTVQTDVKGDLR"
     gene            complement(84766..85122)
                     /locus_tag="ACL8AS_000256"
     CDS             complement(84766..85122)
                     /locus_tag="ACL8AS_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HGS1228191.1"
                     /translation="MLEFIEYPKCSTCKKAKQELNQLGVDYKAVHIVEETPSQEVILN
                     WLETSGFELKQFFNTSGIKYRELGLKDKVGSLSNQEAAELLASDGMLLKRPILVENGT
                     VKQIGYRKSYEELGLK"
     gene            complement(85135..85647)
                     /locus_tag="ACL8AS_000257"
     CDS             complement(85135..85647)
                     /locus_tag="ACL8AS_000257"
                     /EC_number="2.1.1.63"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001170346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003908 -
                     methylated-DNA-[protein]-cysteine S-methyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HGS1228192.1"
                     /translation="MQKKYVKILYSSPIGILSLVADDHYLYGIWVQEQKHFERGLGDE
                     TIEEVVSHPILDPVIACLDDYFKGKPQDLSNLLLAPIGTNFEKRVWDYLQGIPYGQTV
                     TYGQIAQDLQVASAQAIGGAVGRNPWSILVPCHRVLGAGKRLTGYAAGVEKKAWLLEH
                     EGVDFKDINK"
     gene            complement(85647..86141)
                     /locus_tag="ACL8AS_000258"
     CDS             complement(85647..86141)
                     /locus_tag="ACL8AS_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase family protein"
                     /protein_id="HGS1228193.1"
                     /translation="MEIRLAFPNEVDAIMQVIEDAKKCLADAGSNQWQNGYPNADVII
                     DDIISGQAYVALEEGELLAYAAVTKSPEEAYEAIYEGNWQAGESEYLVFHRIAVAADV
                     QGKGVAQTFLEGLIEGFDYLDFRSDTHAENKVMQHIFEKLGFKQVGKVPVDGKRLAYQ
                     KLKK"
     gene            86276..86722
                     /locus_tag="ACL8AS_000259"
     CDS             86276..86722
                     /locus_tag="ACL8AS_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HGS1228194.1"
                     /translation="MKTTFSYPKWAEIPNIDLYLDQVLLYVNQVCAPISPNKDKGLTA
                     SMVNNYVKNGYLTKPDKKKYQRQQIARLIAITTLKSVFSIQEIAQTLNTLQTQASSDQ
                     LYDAFVDYMNQGIDPANPIIQTSCQTVKLYHQTLDLIDHTQEEVIQ"
     gene            86719..87366
                     /locus_tag="ACL8AS_000260"
     CDS             86719..87366
                     /locus_tag="ACL8AS_000260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001097995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HGS1228195.1"
                     /translation="MNTSLKLSKQLSFGEEIANSVTHAVGAVIMLILLPISSIYSYEA
                     HGFLSSIGVSIFVISLFLMFLSSTIYHSMAYGSTHKYVLRIIDHSMIYVAIAGSYTPV
                     VLTLMNNWFGYLIIVIQWGTTIFGILYKIFAKKVNEKFSLALYLIMGWLVLAIIPAII
                     NQTTPVFWSLMVTGGLCYTVGAGFYAKKKPYFHMIWHLFILAASVLQYIAIVYYM"
     gene            complement(87387..87968)
                     /gene="pdxT"
                     /locus_tag="ACL8AS_000261"
     CDS             complement(87387..87968)
                     /gene="pdxT"
                     /locus_tag="ACL8AS_000261"
                     /EC_number="3.5.1.2"
                     /EC_number="4.3.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004359 - glutaminase activity [Evidence
                     IEA];
                     GO_function: GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA];
                     GO_process: GO:0042823 - pyridoxal phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase glutaminase
                     subunit PdxT"
                     /protein_id="HGS1228196.1"
                     /translation="MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSG
                     LILPGGESTTMGKLLRDQNMLLPIREAILSGLPVFGTCAGLILLAKEITSQKESHLGT
                     MDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEILATVNNQIVA
                     AQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS"
     gene            complement(87969..88844)
                     /gene="pdxS"
                     /locus_tag="ACL8AS_000262"
     CDS             complement(87969..88844)
                     /gene="pdxS"
                     /locus_tag="ACL8AS_000262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012054698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0042819 - vitamin B6 biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0042823 - pyridoxal phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase lyase subunit
                     PdxS"
                     /protein_id="HGS1228197.1"
                     /translation="MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMAL
                     ERIPADIRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYIDE
                     SEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGEPGTGDIVQAV
                     RHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHEHGKLPVVNFAAGGVATPA
                     DAALMMQLGAEGVFVGSGIFKSGDPVKRASAIVKAVTNFRNPQILAQISEDLGEAMVG
                     INENEIQILMAERGK"
     gene            complement(88996..90375)
                     /gene="nox"
                     /locus_tag="ACL8AS_000263"
     CDS             complement(88996..90375)
                     /gene="nox"
                     /locus_tag="ACL8AS_000263"
                     /EC_number="1.6.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="H2O-forming NADH oxidase"
                     /protein_id="HGS1228198.1"
                     /translation="MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGC
                     GMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKE
                     SYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
                     HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHN
                     IRLALGQTVKAIEGDGKVERLITDKESFDVDMVILAVGFRPNTALADGKIELFRNGAF
                     LVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGIVGAYNACGHELEGI
                     GVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIV
                     FDKDSREILGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYI
                     TMAALTAEK"
     gene            90669..91592
                     /locus_tag="ACL8AS_000264"
     CDS             90669..91592
                     /locus_tag="ACL8AS_000264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0017013 - protein flavinylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HGS1228199.1"
                     /translation="MTLRSHSERLMGTTITISLVDEQADIFLQKSFDLLKELEYRFNA
                     NSQESELMEINYQAGIAPVTVHPDLFELISLGLEHSLALSSHLNISIGPLIQTWRIGF
                     SDAKVAQPQEIESVLPLINPHGIELDSSTSTVFLKQKGMKIDLGCLAKGYSADKVAQF
                     LRKEGVTSALINLGGNILTIGKNQARGDNPWQIGIQDPANPRGNHLMTIPVVNKSVVT
                     SGIYERHLTVDGQDYHHIFDSQTGYPVETELASLTIISDKSVDGEIWTTRLFGERPAS
                     ILWQVENLEGIEVILIDKEGHLSCSSGIPTL"
     gene            91652..92257
                     /locus_tag="ACL8AS_000265"
     CDS             91652..92257
                     /locus_tag="ACL8AS_000265"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="HGS1228200.1"
                     /translation="MLKLIAIVGTNSKRSTNRQLLQYMQKHFADKAEIELVEIKAIPV
                     FNKPADKQVPAEILEIAAKIEETDGVIIGTPEYDHSIPAVLMSALAWLSYGIYPLLNK
                     PIMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDLD
                     VIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENL"
     gene            92276..93520
                     /locus_tag="ACL8AS_000266"
     CDS             92276..93520
                     /locus_tag="ACL8AS_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000673688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HGS1228201.1"
                     /translation="MKFVGLVGSNYDQSYNRKLLEFIRRYFKLKFELEVLEIDEVPMF
                     NQDEKWDESFQLRYLYNKITRADGVIIATPEHNHTISASLKSVLEWLSYEVHPFENKP
                     VMIVGASYYDQGTSRAQVHLRKILDAPGVNAYTLPGNEFLLGKAKEAFDNNGNITNEG
                     TVKFLETCLDNFVKYVGVVSKLKKPKPIESEDLDCGKPIATTITEVDPDDPEWVEKVA
                     AITGAVSGDTYVKLDHGILTVNQIDMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMF
                     AKRVPPQSGSRMSTVHGSLPPARMKNVEWVIGTLRNGNQEYVRTIVPGSPAGVINTHN
                     YQAMYYPDGSYAGINEIVFNFQPWLDWYLKETGQRLVGGSGPFAPAAGGHGDADATSG
                     ASDSGDAGGHGGDADATAGASY"
     gene            complement(93637..93894)
                     /locus_tag="ACL8AS_000267"
     CDS             complement(93637..93894)
                     /locus_tag="ACL8AS_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002901318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 family protein"
                     /protein_id="HGS1228202.1"
                     /translation="MDPKKIARINELAKKKKTEGLTPEEKVEQAKLREEYIEGYRRAV
                     RHHIEGIKIVDEEGNDVTPEKLRQVQREKGLHGRSLDDPNS"
     gene            complement(93936..95972)
                     /gene="glyS"
                     /locus_tag="ACL8AS_000268"
     CDS             complement(93936..95972)
                     /gene="glyS"
                     /locus_tag="ACL8AS_000268"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004820 - glycine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006426 - glycyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HGS1228203.1"
                     /translation="MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAI
                     QTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVE
                     DIEFREIKGEEYVYVTKEEVGQAVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVH
                     TLTVLLDEQEFDLDFLDIKGSRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCER
                     EQMIVDQIKEIEAKHGVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTS
                     MKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQ
                     KLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIY
                     KFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAV
                     LAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYA
                     LKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEV
                     SKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQ
                     LKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK"
     gene            complement(96232..97149)
                     /gene="glyQ"
                     /locus_tag="ACL8AS_000269"
     CDS             complement(96232..97149)
                     /gene="glyQ"
                     /locus_tag="ACL8AS_000269"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018163989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004820 - glycine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006426 - glycyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HGS1228204.1"
                     /translation="MSKKLTFQEIILTLQQFWNDQGCMLMQAYDNEKGAGTMSPYTFL
                     RAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEK
                     LGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATSPVTAE
                     VTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEISDQEMLLENFD
                     KFEKEAGRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVA
                     KTFVAERKRLGYPLLDEETRAKLLAEDAE"
     gene            complement(97343..98104)
                     /locus_tag="ACL8AS_000270"
     CDS             complement(97343..98104)
                     /locus_tag="ACL8AS_000270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HGS1228205.1"
                     /translation="MDNLYLVKDDSQLATFRDFVVRNTEKLKDYQSFLKNELAVCDLP
                     QAVIWSDFNAATQIIRESAVPAYTNNRRMVMAPDLAVWKELYLYQLMDYECSQQTQAI
                     ESHYHSLSENFLLQIVGHELAHWSEHFLDDFDGYDSYIWFEEGMVEYISRKYFLTEEE
                     FQAEKICNQSLVELFQKKYGWHSLNDFGSSTYDKNYASIFYEYWRSFLTVDKLVENLG
                     SVQAVLDSYHLWANTEKTFPLLDWFVQQKLIEKEI"
     gene            complement(98377..99219)
                     /locus_tag="ACL8AS_000271"
     CDS             complement(98377..99219)
                     /locus_tag="ACL8AS_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HGS1228206.1"
                     /translation="MDTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHID
                     TAAIYQNEESVGQAIKDSGVPREELFVTTKLWNSQQTYEQARQAFEESLEKLGLDYLD
                     LYLIHWPNPKPLRENDQWKIRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA
                     KILPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKS
                     IAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVD
                     DVDF"
     gene            complement(99232..99372)
                     /locus_tag="ACL8AS_000272"
     CDS             complement(99232..99372)
                     /locus_tag="ACL8AS_000272"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228207.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEVVDRTDEVSNNTYGKATLTWFEES
                     IK"
     gene            complement(99475..100866)
                     /gene="pgdA"
                     /locus_tag="ACL8AS_000273"
     CDS             complement(99475..100866)
                     /gene="pgdA"
                     /locus_tag="ACL8AS_000273"
                     /EC_number="3.5.1.104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050119 - N-acetylglucosamine deacetylase
                     activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0042545 - cell wall modification [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-N-acetylglucosamine deacetylase
                     PgdA"
                     /protein_id="HGS1228208.1"
                     /translation="MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQK
                     SFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKD
                     KLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKIEETEKTSLGKVHLTEDGQ
                     PFTLDQLFSDASKAKEQLIKELTSFIEDKKIEQDQSEQIVKNFSDQDLSAWNFDYKDS
                     QIILYPSPVVENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKHQKVVALTFDD
                     GPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILS
                     QLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDW
                     KSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNT
                     RLKAHELYYSRDE"
     gene            complement(101104..101472)
                     /locus_tag="ACL8AS_000274"
                     /pseudo
     CDS             complement(101104..101472)
                     /locus_tag="ACL8AS_000274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000603324.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
     gene            101711..102688
                     /locus_tag="ACL8AS_000275"
     CDS             101711..102688
                     /locus_tag="ACL8AS_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HGS1228209.1"
                     /translation="MLKLGVIGTGAISHHFIEAAHTSGEYQLVAIYSRKLETAATFAS
                     RYQNIQLFDQLEVFFKSSFDLVYIASPNSLHFAQAKAALSAGKHVILEKPAVTQPQEW
                     FDLIQTAEKNNCFIFEAARNYHEKAFTTIKNFLADKQVLGADFNYAKYSSKMPDLLAG
                     QTPNVFSDRFAGGALMDLGIYPLYAAVRLFEKANDATYHAQQLDNSIDLNGDGILFYP
                     DYQVHIKAGKNITSNLPCEIYTTDGTLTLNTIEHIRSAIFTDHQGNQVQLPIQQAPHT
                     MTEEVAAFAHMIQQPDLNLYQTWLYDAGSVHELLYTMRQTAGVRFEAEK"
     gene            102685..103767
                     /locus_tag="ACL8AS_000276"
     CDS             102685..103767
                     /locus_tag="ACL8AS_000276"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HGS1228210.1"
                     /translation="MKTKLPTEWQELSDQLGFQEFTPIQTQLFELLLAGENLLGVSQT
                     GTGKTLAYLLPSLLRLQKKKAQQLLILAPNTELAGQIFDVCKTWAEAIGLTAQLFLSG
                     SSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMNVETIILDEFDQLLDDSQIHFV
                     EKITHYAPRDHQLVYMSATTKFDQEKIVPNTRTIDLSDQKLDNIQHFYMQVDQRHRVD
                     MLRKLAHVEDFRGLVFFNSLSDLGNAEEKLQYRDILAVSLASDVNVKFRKIILEKFKD
                     NQLTLLLATDLLARGIDIDSLECVVNFDIPRDSETYTHRAGRTGRMGKEGYVITLVTH
                     PEEIKKLKKFASIREIVLKNQELYIK"
BASE COUNT        31107 a        23153 c        19038 g        30527 t
ORIGIN      
        1 ttatctacaa cctcaaagct gtgctttgag caacctacgg ctagcttcct agtttgctct
       61 ttgattttca ttgagtatta cagtgaacaa tttttctagc tattgtaaca aaaaagtcac
      121 tcgaaggcaa cttttttcgt ccataaactt tcaaaagaga atggcttatt cagaactaaa
      181 agccgcagct ttttgcattt ggtaatactt accctttcta tccatgagtt cttgatggtt
      241 accatattca acaatatcac catctactaa gacaagaatt aaatccgcat cctgaatggt
      301 tgacaaacgg tgagcaatga tgaagcttgt gcggcccttc atgagttttg caaaggcatc
      361 ctgtaccagc acttctgtcc gtgtatcaat ggaagaagtt gcctcgtcta agataagaat
      421 ctttggaata gccagaaaga ctcgggctat ggtcaagagc tgagcttggc cgacagagag
      481 agattctcca gcattttcca acttggtatc gtatccctgt ggaaactgtt ggatgaaaaa
      541 gtctgcatta gctgctttgg cagcagcaat tacttgctct cgactggctt caggattgcc
      601 aaaggcaata ttatcatgaa tggtcccttg tgtgagccag gtttcttgaa gcaccatgcc
      661 aaactgctgt ctcaatgatg ctcgtgtata atcataaatg gattgcccat ccagcaagat
      721 atctcccgag ctaatgggat aaaaacgcat aaggagattg ataagagttg attttccagc
      781 acctgtcgga ccaacgatgg ctatcttact accagctgga atatcgatag acaagtcctt
      841 aatcaaaatt ttttcaggat ggtagccaaa agagacatgt ttaaaggaaa tagctccctt
      901 aacttggtca ctggtcaaga cttccttacc tgtttcagcc acttcagggc tatctaagac
      961 tccatagata cgctctacgc aagccagagc actttgcaac tcagctagca ctgaagaaat
     1021 atcgttaaag ggcttggtgt attgctgaac atagttcaaa aaagtcacta aacgaccgac
     1081 ggtcaaggct gaacccatca tgatacgata agctcctact ccagctaaaa gggcataaat
     1141 gagtgcattt acaaagcgag tcgaaggatt gaccgttgaa gaataaaaga tggctgactg
     1201 agaatagcct gagtagttgt catgagcctc acgcaatctt tggataaatt ctgtttgagc
     1261 attgaaggac tggattatag tctgctgact aagcgattct tcaatcaact gagtctgaat
     1321 tcccctcgtc tctgtttgct tctggaagag atgataggat ttcttggcaa taaagcgtga
     1381 aatcaccatg gacagtggcg tcaacagcaa gactaagaga gtcatgagga gatgaatttg
     1441 gagcatggct agaatactga ccaaaatcat caaaacacca atgaaaaatt ggttaaaaat
     1501 catggtcaag ccagctgcca actgttcgat gtccgtggtt acacgactaa ccatctctcc
     1561 actaccttgc ctatctacaa aggcaatcgg taaacgatgg agcttatgga tgattcgctc
     1621 ccgtaaatct ctggtataag agaagattag acgattatag aggagaggat tggcccattg
     1681 taccagagta tttcctatta ccaccaagag catctggaga aaaatctgcc aaaaaactgg
     1741 tgatgaacca gccactagga cttggtcaat gacctgccca atcagaatag gtaggtaaat
     1801 tgataagcca acttgagcaa tagttcctag aaaggctagg aaaaggagga aaggatggct
     1861 tgctaaatct acgactaaac gtttgagcgt ctggtttaca gtttgtcgtt tcattctagt
     1921 cctcctttcc atgttgggat gcattgattt cacaatagac ttggctggat ttcatcaagt
     1981 catcgtgctt gccaacagct agcaactcac ctttttccaa gaggagaatc tggtccgcca
     2041 tctgtaaagt tgaggttcgt tgagagatca aaattaagct cgtgtttgga aaattttctc
     2101 taatagcttt caagagcttg gactctgtaa tggtatccag tgccgaggtt gcatcatcta
     2161 ggatgagaaa cggagcttgg cgcaagactg ctcgggcgat agacaatctt tgtttttgtc
     2221 cacctgagaa atttcgcccc cctgcctcaa ctagagcatc caagagtcct tccttttcac
     2281 tgacaaaatc cttagcttgc gcaatctcca aggcctgcca gagttcctgg tcagatactt
     2341 cttgattgaa acctagagtc aagttggaac gaatggttcc tttaaagagt tcgacctttt
     2401 gaggtacata ggcaatccaa gaccgccact gctccaaatt aagaggacta cgtccatttt
     2461 gataaaggtc aatgttcccc ttgtctactg gataaagtcc aagtaagagt tgcaccaagc
     2521 ttgatttacc agaaccagtc cccccaatga taccaaggat ttgtccttga gtcatatcaa
     2581 aggaaatgtc tctcagagaa ggctgggccg catcaggata ggtaaaggtc aattcttgga
     2641 cttgtaaaac ccgatcactg gtaacttgct tttgttctaa ttctgaatgg atgttttcgg
     2701 gagattccgc aaagacctcc tcgattctct tggctgagat gtaggactgg ttgagggaag
     2761 tgatcagcat ggcaagcttg accaattcca ccaaaatctg taagaggtaa ttgataagag
     2821 caatgagagc accttgactg agcactcctc cttgaattga aatatagcct tgccagataa
     2881 taacgagaag agttccattg acaatcagat aggtcagagg tgttaataaa ctagaccaga
     2941 aacctgtctt ttcttgtaat ctagcataaa cttggttaag ggtttgaaaa atctgtaact
     3001 ctcgtttttc ttgaccaaaa gcacgaataa cccgcgtccc ttgcaattgc tggcgcgttt
     3061 cctgaaccag ttggtccgtt ttctttctga gactactgta gagaggattg accaatcgag
     3121 ataaccctac aatgacaatg gtcaaaatgg caaccatgac taagaaccag aaagtcaact
     3181 cagctgagat tcgataagcc ataaaaatgg caccaaaaac gataatgggc gctcgtaaaa
     3241 agagacgcag gaattgattg ataccagtct gaatctggta ggtatccgaa gtcaagcgag
     3301 tgaccaaact agaagttgtc agacggtctc tgctgtcctt gggcaaggaa agaatatgac
     3361 gataaagatc gtttgtcaat tccttagcaa aacctactgc tgcctttgct gagtaaaatt
     3421 gagctatcaa ggccactaaa acgccaatta ctgcaaagat aaggagcaga ccaatctgca
     3481 tccagagatg accttgatct ccctgaggta aagattggtc aacaatccca gcaatcacca
     3541 tgggaaccaa gagctcaaaa acagcttcta acagcttgaa caagggggct aaaattgatt
     3601 ccttgatgta gggtttgaag taagataata ggtgtttcat aaatcccttc tattcatatt
     3661 ctagaaatga agaaagtggg aagccccact ctctgtttta tttgtttaag taaggcaata
     3721 gatagccata tcctgctttt tccatctcat ccttggccac aaagcgtaaa gaagcagaat
     3781 tgatacagta acggaggccg cctaactccc gcggtccatc tgtgaaaaca tgacccaagt
     3841 gagcactgcc tgaacgagaa cgaacttcaa ttcgctccat tccatggctc agatccttgt
     3901 aataatgaat caactctttg gaaatcggac ggctaaaact tggccaacca caacctgaag
     3961 caaacttatc cttggcaaaa aagagtggct cacctgtcgt aatatctaca taaatcccct
     4021 cttcaaaggt ttggtcatag gcattggtaa atggagcctc tgtagcagct tcttgggtga
     4081 cacgataaga ctcttcagat agactggcct tcaacacctc ttgactaggc ttttcatagt
     4141 ttgctgcatc aatcaatggc ttatcagcat cggtcacatc gatatgacag taacctgaag
     4201 gattcttcct gagatagtct tggtggtagt cttcagccag aatgtagtgg cgtaattgct
     4261 ccacttctac tgcaatcttt cgacccagca tgcgttcctg ctcctgcacc actgtgtaga
     4321 tagctggcaa atctgcttca tcctgataat aaatcccagt tcgatattgg cggccacggt
     4381 cattcccttg ttgattgata gatagaggat cgataactcg gaaataataa agtaaaatct
     4441 ctctgagtga cacttccttc tcatcgtaaa tcacttggac cgtttctgca tggtctgttt
     4501 ccttgatcaa ctggtaattg gtcgtttcga cttgaccatt agcgtagcca acactggttt
     4561 ctagcactcc agaaatgcgt gaaaaatatt cctctaggcc ccaaaaacaa ccacctgcta
     4621 gataaatttc tgccatcttt atttctcctt tatcacgttt ttaactaata ctcttcgaaa
     4681 atctcttcaa accacgttag cgtcacctta ccgtatatat gttactgacg tcgtcagttc
     4741 tatctgcaac ctcaaaacac tgttttgagc agcctgcggc tagcttccta gtttgctctt
     4801 tgattttcat tgagtataaa cttcttttca caaaaaggat atgaaaccct ctggttaaga
     4861 gtttccccat cctatcttct attctttatt ttgcttctac acggacacct tgggtatcaa
     4921 ctctcaagtc atgcagtttt cctttgaaag gttgcttttc caattctgcc ttaattgttg
     4981 gcatcttgtc atgagaagcc agaaccataa ctgtcggccc agcaccagaa aggtaggttg
     5041 cataggcccc attttctttg gtcacttgct taatcatcgc aaattctctt accaagtcct
     5101 gacgatagcg ctcatggaag aggtctccct cgattgcttg cccagcggtc accatgtctc
     5161 ctgccaacaa ggcagcaacc gctacattgg cgatagaact tgcagcaaca gcttccttat
     5221 aagataattt tttaggcaag acactacggc tgtcgcgagt acgtaattca tagtttggaa
     5281 tgtaagctag aaaatcacac tctggaaagt ctgctacgat agcagagact tgcccttcaa
     5341 cagaacttgc aataacgaga ttaccataaa tggctggagc cacattgtca ggatgccctt
     5401 caatcttggt cgctaactgc aatttttcat ggtctgataa gttgagttga cccagttggt
     5461 tggctagttc aatcccagca acaataaccg agctggaaga acccaaaccg cgcgccaaag
     5521 ggacatcact ggtcattttc aagcgtcttg gttgcaagtc tggtacaatt tgtaaagcga
     5581 ttttgagcaa gagattacgc tcatcatgtg gaatccattt gccaatctgg tgttcaatca
     5641 gccactcatc tcgttcttcg cagacctcaa tttgaagata cttggttaca gctacaccga
     5701 ccgagtcaaa acctggcccg atattggcac tggttgcagg tacaataatc ttcatcttat
     5761 tctcctagca ccttgaaggt attcaagagg tcgaattctg aaaccttctt caattcagct
     5821 gagacatttt caagctgggc tttattaatc ttgtgtgtga tgataacgac acgcgccttg
     5881 tcaccctctt tgccatcttg aaggatttgc ttaaaggaaa tatcttgagc attgaagatt
     5941 tcagccaact tcaagacctg accttttgag tctggagcca agattgagaa atagtagttt
     6001 gctttgacat cttcaggatt tgccaagacc aagtcacggc tatattcgtt gaagtctttg
     6061 ccaatggtac catcattcaa acgacgaacg atacggacaa tatcagctac aacacttgtt
     6121 gcagttggtt tttgacccgc acctggtccg tagtacatag actcaccaat accgatagat
     6181 tctacaaaga cagcgttcat tacgccattc acactagcaa gtgggtgcgc tttaggtagg
     6241 aaggttggag tcacttctgc agcaatacct gaagaagttt cctcaataga accaaccaat
     6301 ttcactacgt aaccaaactc ttgagctaca gctacgtctt ctggtgtgat attgcggatt
     6361 cccttgtggg ctacatcatc aaaggcaatc ttcatgccaa aggcaaattg gctcaaaata
     6421 accatcttgt aggctgcatc aatcccatct acgtcattcg tcggatcgct ttctgcaaat
     6481 cctagacgtt gtgcttccgc aagagcatca tcgtaagacc agccttcttc caccatcttg
     6541 gtcaccatga agttggaagt tccgttgact actccaagca cgcgcgtaat tttatcagaa
     6601 gccaaggaat ttgctaaagt acgaagaatt ggaatcccac cagcaactgc tgcttcgtag
     6661 taaagtgcta ccttgttagc ttgagcgatt tctagcaatt ctgcgccatg gacagctaaa
     6721 aggtccttgt tagcagtaac aacgtgtttt ccagcttcca aggcacgagt gataaaggtt
     6781 ttagcaggct caatacgccc catcaattcc actacgatag taatatcctg gtctgataaa
     6841 atatcatcca cattggttac aaagttaaag tcattccctg ctgcaagcaa gcgatttttt
     6901 tcatcttcat ccttgaccaa taccttagca actttgatat ctgaatgtgc tgattgattg
     6961 atttttcctc cattttcctt taggaggaaa ggcacaccac ttgcaacggt accaaatcct
     7021 agtaaagcaa ttttaactgt catctttatc tcctcgaaat tttctaatat agccattata
     7081 acagaatttt gtgaaaattc ctattatagt aaatcactat ttcagtataa aaagaaaaaa
     7141 cgaatcagac gattcgctct tcttaaaatc tgaaaatagc tttccagaaa ggattagccg
     7201 attttttgca gattgagcac tgcatcgtga ctcatcaaga cttgaccata ctcttgtaag
     7261 actgagcgac tgatatcact atcgtctgca aactcgcgca tacgggccaa cagccaagct
     7321 ggatatgggc ttggatgatt ttcaatatcc actaaaatgg tcaaataata gcgctcgttc
     7381 attttgtaga gttcagaagt ttccatttca aaagtcactg tcttggcaaa aactaccaag
     7441 tcagccaact tagcaaaaga aaggatgtag tagatgtaag gttctttctt actctcagct
     7501 tcttgttcag cctgctcttg ctcttcttcc ttggcttcaa cttgctcaag agattgaatg
     7561 gcttcgatat catccttggt tttgtctgcg atgctttttt ccagggtttt gataaattca
     7621 tctggagaca tttgagccaa ttcttccata tctggcaaat ccgataagtc ttcaaaatct
     7681 agattttggt caatctttga cttggtcaca aagacatcta ccttatcagg ttttggagtc
     7741 acacggaagc tcaacatgcc tgtatccaga aagctatcag gcatctctag ctcatccaag
     7801 atagcataaa agaactcttc tgttttttct tgaggaacga gaaagtcagc aatctccatt
     7861 ccacgatcca tcaaatcctc taaagacatc gtgattttta aagttgtatc actaatttgt
     7921 ttcattttca ttgctagtaa cctcatactt tcagttctat ctattatact agatttttac
     7981 gattttatca aaagaaggct cctctatacg gatagatttt ccctagggtc tttctatagg
     8041 agactccaag agaaaatttc tgcagacaga tagaaaaagc cttcaaaatc ggctcttagc
     8101 cgactttgaa gaccctatac atcagaatac ttataattta aaggttgcta caccgaggat
     8161 agaacgattt aagtttctga gaatttgaag actttgctca aatttcttat aacgagtcac
     8221 tccgtactct tcaacaagaa ggactgtatc tctttccaaa agagatgata catcctgtaa
     8281 atctacaaaa tgcattcctt ttaaagcttc ttgactctgt ttcaatttat ctaggatagc
     8341 tttatttgag ctaacgatgg tcaattcctg tccagtattt ttgtatgaca aaacatctgc
     8401 taggttagca attgttgtaa tctctgttac aaaatcaatt tgatactgag aaaaatcacc
     8461 tactctattg attgttggat taaagagata aactaacaca tttcccatca caaccaaaat
     8521 cacacaaacc actccaataa caactaaacg aagaatcaga tttttcacat ttaagccaag
     8581 cgctgtttca ccatttgcgt tcaattcttt agagttgatg gtttccagtt tttcaatttt
     8641 cacatttgca taagcatgtt taaatttctc aatcaaccca tcaatttttt tctctaacaa
     8701 gtcattggca tctttacttg atgtcaaaat tttcacacca acccctgcat cgtcaatcat
     8761 atagtagacg gtcaattttt tccaccaata gtcattcgtt gaatttttca aggttgtttc
     8821 tgtcgtgtct aattcactgg caattttttt caactcactg ggttctacat cattgaaaag
     8881 ataagctcca ttcaaattac catcaatcaa tttcccataa aaatcactat aaccaccaat
     8941 ttgatgattc aaaatcgttt tggccgaatc ttctggagga gtgattttat agataagata
     9001 agttgaataa cttgttgtat ctttgacagt gtttttattc ctaactgctt taattgtaaa
     9061 tggtacagca atgagagcaa ataaagcgat gagagctaaa atatttgctt ttcgcttttt
     9121 ataaagattt gcaaacaaat cagctactga ataatgttca aacatgattt ttttctcctt
     9181 tgtttagtag atactagttt tcctttgtaa gcatttttgc tacaaatata atcacaagaa
     9241 caattcccca gaattgcatt gtaaataaat tgaagaaact ttctgaaaag ctgcttcttg
     9301 gcataaagaa tagattattc aagatgagta gggataaagc aaataggatt gtccttgagc
     9361 gataggctac ttgcagcatg gctataaata atacgccgag taagaaacta agcagaaaga
     9421 ctccaatcat accatagtcg gtatacaact ccatgatata actacttccg ataccatgcc
     9481 ctttcaagta ttccttgttc aagacaagat aggatagatt gtgggcataa ctattactat
     9541 caatagctag ttccacacta ttggttgtat gttcaaaggc ttttcctccg aaaatggctc
     9601 ccaaactccc ccttgcaaaa taatcaagaa caggaccaaa agtaaaatta cggaaatctc
     9661 ggtaagggag gctactgtta aatagaaaac ctcgagccag aacaccaaaa ctagtccctt
     9721 gtttatagat aaagtcaagt aagatatccc agaaacctgt atgggaaact tggacattat
     9781 cccgtacata attgagtact cccatcgcta acatgagaat aggagaacct acaaaaatcg
     9841 ctaacttttc tttaaaccca atccattttc ctttttcagt ttgctcccgc ataaagtaat
     9901 aaacaaaagc aaataaaata cttaaaataa agggatttcg tgtcccaatt gccaaatgaa
     9961 tagtattagc tgcaataaag gagacaagca ctgctgtggc ctgcaatttc tttggcttgg
    10021 ttgccagata catacacatt gcatagaccg taaaggtaga caaaatgtag gtaaaataag
    10081 gcagtttact ttcaaaattt gcatagtagg catagtagga agtctgcaaa cgatacaaga
    10141 gccgttcaaa taaccgaatg aaatagaaag gataggttag aagaaaaact actagtgata
    10201 caaagcgtaa ccgcttgata taaacctctt ttagagaatt tcctatattt gctactttta
    10261 ttttcttcct agctatgaag taacgagcca gaatgcctcc tgtggtcaag cccagaatcg
    10321 aaaccatgac aactataaag gcaaaacgat aggctattgg atgataggta tccaaagcac
    10381 catccctaaa ataatcaatg gtcggtcttg ataccagaaa tacaaaaatg gttaaataga
    10441 aaataaaatg gattaagtaa tacttgatat cattccaaca agcaattaag ctactaacca
    10501 acaagaacaa taaagtagaa agtaagctaa cattattatt attaaacaga tacacaattc
    10561 cacttactag cgtcaaggca taactgacta tggtcaaact aaataataat cgtttcccat
    10621 caatcacttg gtcacccccg ttctaatgta attttttaga tttttcaata tttttcagta
    10681 ataagaatcg atataaggaa atatttatga atagggccaa agcactaatt cttctcccct
    10741 tacggaaaat tggattccta gaaatagcaa aggcatggcc ttttaaaaaa cgatgaatct
    10801 gagaataggc ttcaaactgt ttatactgat catctagcaa catcttatcc agaataaaga
    10861 agtgggcata ggccaatctg aaaaaagcga cctctttcaa gtcaggatag tttttcacaa
    10921 cttcattata aaacttttgg tagatatcaa tataggctaa atccttctct gcatagggtt
    10981 tggtcgtaat actatcccct ctatggaaat agtaataata gggtttagta ttaaccacat
    11041 acttcttggc caacttgatt aaatcaaaat ggtaataggc atcttcgtaa atcaacccct
    11101 taggaaagga tagggcagtt gcaatctgtc tcttgattag cttattgcaa atcgtcccag
    11161 gtattttttc acctatgagg tattccttta gaaatgtttg agaatcacag acaaaatagt
    11221 catcctgatt ggctgactgt gggctttcat cattagcata gacattcatg acaccacagc
    11281 tcgaaacatc cgcatcttct tgaactaatt gctcatataa gctctgaatc atttctggat
    11341 ggatataatc atctgagtca ataaaaatca gataatcccc gtgagcctgc ttcatcccat
    11401 catttcgtgc ttgcgacaat ccttcgttct ttttatgaag cactgacacc ctggcatctt
    11461 gttcagcgat tgaatcacac aagcgaccac tttcatctgt tgcaccatca tcaacaagaa
    11521 taatttccag attttgatag gtctgcttct gaatggaagc tatcgatttt tctaggtact
    11581 gcgccacatt atagactggc acaatcacac taattaatgc agtttccatg ctactcctct
    11641 aatagttttt ctacttgttc gatttgtttt gtaattgtaa attgttgaat gaattggcta
    11701 gcctcatcga catcaaagtt tgaggcagaa gtcatgtaat tagtaatcgc ctgagctgcc
    11761 tcttgattgc tctcaatgat ttgtccaaat cgtccttctt gggataattc ctcagcccct
    11821 ccaacgtccg tagagataaa agggagtccc agactcaagg cctccacata cactccagga
    11881 aaaccttctt gtttagacat agacaagaga actttcgtct gagataaata ctgataagga
    11941 tttttttgat aaccaaggaa atgtacatag tcctcaatcc catactcttt gactcgtttt
    12001 ttcagttcct cttccatatc accagccccg ataaaataga gatgatagtt ttttccctct
    12061 tggtgtaata atcgtatcac ttccactaca cggtcagaac ccttattttc ctcgatccgt
    12121 ccgatagtac agatactttg aggagcaatc tcgatatcga tcttctcttg agatttttct
    12181 agaatagtct gaaaatcata tccattgtag attgtctgta atttagaagc ataatctgga
    12241 taaacttcct tgatagaatt gctggtcttt tttgaaatcc ctacaattgt attcgcagca
    12301 tccaactggc ttctatgtga ttctctttta gagctatcct taagaagttc ttcaatactt
    12361 ccatgaatcc aagatatctt cttgacttct cttcttttag agaacaacag tggtggattc
    12421 ataatggtaa aagaaacttc aacatcataa tcatctttta caagcaaacg acgagccagt
    12481 cttggaaaat aaattctcat tctccacaaa aaagctcgta accatctggt ttggcgataa
    12541 tcttgaaggg attttaaaat gcgtacatgc tttggaacag attcatatcc cttgtcaaag
    12601 tgctccattt caagaatatc aatatcatac ttttctggat ccagatttga aacaatggtt
    12661 gatagaatct tctctgcacc acctccaaga gaaaaagacc acataaaaaa taagattttt
    12721 ttcttagcca ccatattctc ccttgtattt tgtataagac ttatccatat cagcaatgac
    12781 agtatcatga tgcggtacct gcttgtctgc tggtggaggc gtcatataat ccccaaaagc
    12841 agttctgaga tagacatcat agccgattgg aataggcatc tctgttcctt caaatggcaa
    12901 gaaaagattg tcttcaaaag atgtgattgg gtacttgttt ctcatgtagc caggacctga
    12961 gcataattct gtaatgccat cacaatcagc caaatcatac ttagtcattt ctttctcagc
    13021 ttttttccag atgcgataac ggagagattt tggagtcaaa cccagtaaaa tgcgacttcc
    13081 ccatttcatg agagcaccat gcttttctgg aatagtttgc gcacaaaaga gtgaataaat
    13141 caaggcccaa cgaacctgtt ttttccgctc agctggattt ttcggataat aatccaaagg
    13201 caaaatatcc aaggccagac catgtggcaa atccaaatcc tgctgataag gcttgataca
    13261 ggtggtttcc ttgtcacgaa tggtaataaa aagattacga tcaacaaaat tcttatgact
    13321 ctttgacaag aaataacgtt catctgcata acgaggccat aattctgcta atttctcata
    13381 atctttacga ggcataaaaa agtctaggtc gtcgtcccaa ggaataaatc ccttgtttcg
    13441 aagggcacca atagcgcctc cgccacagag ataacagagc aaatcatgtt ctttacaaaa
    13501 ggccacaaaa tattcagcca tctccagact acgagcctga attgctttta aatcagtcat
    13561 attgttcatt attctttcta tcgtatcgtt tcattatacc acaaacaagg ggtgaaaatc
    13621 tattgcagac tgtaaaaaat caaagcctga ctgctatcca aatagctatc aaactttgat
    13681 ttttctgtct tatactcttc gaaaatctct tcaaaccacg tcagcttcac cttgccgtag
    13741 gtataggtaa ctgacttcgt cagtcttatc tacaacctca aaactgtgtt tttagcagcc
    13801 tgcggctagc ttcctagttt gcactttaat tttcattgag tattatctta tctcaagccc
    13861 atttgagcga gcttggtttg atatttgttt tgatcaacca gcaagcccaa gcctccataa
    13921 acatcatagg catctaccca gtcacccagt tctggaatcg tcaatttttc aataccattt
    13981 tttgctccat ccaaaacaga taaaccgttt gttaggagga aagtataggg gacgttggtt
    14041 gaggtcatag caaaaacctt tccaagagct tcagaaccag tgaaaagttt agtgggatct
    14101 ttaatttgct ctaaaattgc tgttaaaact tgttgctgtc tttttgtacg gccgtaatcc
    14161 gcctcatcat catcacggaa acgagcataa ttgagcaggg tcgagccatt catctgctgt
    14221 tttccgactt taatggtttg ggttggagac tcagtctcgg tagcgtataa atcatctccg
    14281 actgtagctt ctgttagggg acgcccattc aatgttgaaa attgagcatc aatcgtcacc
    14341 ccatcaggga aaagcgtgtc aatcgctgtg gcaaaggcct ggaaatcaac caaggcgtag
    14401 tacttaatgt ccaagtcaaa attatctttc aagacttggc gaaccatttc tgcccctttt
    14461 tgcccctctt gttctcctaa ctcgtaggct acgtttaact tgttatctgt ctgttttcta
    14521 ccgttaatca cttgactata accatctata tagaccaaat tatcacgcat gaaactgact
    14581 agcttcattt tcttatctga gcccccgaca tttaatacca taatagagtc agttcgtgtc
    14641 tcaacactgt tctggccgat tcgaccatca gtacccatga ttaaaatatt aactccatct
    14701 ctagtgtcct gaccattaaa gacttctact tgagctgccc gggcatcagc agttttcttt
    14761 gcgctagcat cttggtaacc acgcaaaaac atgaatacca tggccaaagc cacacagacc
    14821 aaaagtgaaa aaatcaccat aaaaattcgt ttaagacgga gcttccgtct tttctttttt
    14881 ggagggaaag agagtgcttg tgatttggat tgtgagcgac tccggttcgc atagcttggt
    14941 aagtcaacct gctcttctct ttcttgttcc aagctagagc tactatttcc cctagcaaga
    15001 gttagctttt cttgcaaata ggcaaactca tttttttctc tctcattgag atagtgaata
    15061 ttttttagca aataatcata acgcaactgc tcatgatgac ttaagggatt ttctttactc
    15121 atcttctctc ctttccatgg tctgatattg gataaatagg ataggcaccc agaattttat
    15181 actggattcc aatcgcttct aattcttttt gggcaaagtg gaccaagtcc ttatcggtat
    15241 aatccacatc gataatgaaa aagtattcac ccagtgctgt cttgagtgga cgactttcaa
    15301 tttttgtcaa gtcaattcct cgccaagcaa aggtcgacag ggccttataa agtgcacctg
    15361 gaaggttgtc aggtaatgtc aaggccaaac tcatcttttc agtttgtgct tgcaagggaa
    15421 tactaggctt ttcagctcct agaagccaga aacgtgtgaa attggcttcc atttcctgaa
    15481 tatcctcggc aatcagttcc aatccatatt cttcagcaga acttctaggt gcaattgctg
    15541 caaagggctg atctggatgt tcggaaataa aacgggccgc ataagctgta ctaactgtta
    15601 cctcgatttg agcctctgga tattgttcat cgatgaattt ctttccttga gccaaggcct
    15661 gtggatgtga aaaaatcttt tcaatcttag tatggcctgg aaccaccatc aactgctgat
    15721 gaataggctg aacgatttct gctactgctt ggatgtgagc ctgatgaaaa agatagtcca
    15781 aggtttcatg aacactaccc tcaatagaat tttcaactgg caccacagaa tagtccacta
    15841 atccttgctc ataagccttg atgacatctg taatgttggc aaaagcctgc aattcctcat
    15901 gaggaaaagc tgtctgcaca acgtggtgtg aaaatgatcc tttgggacct agataagcaa
    15961 ttttcatctt agttcctcta taatttcctc tgggcttagc ttggtcacat ccaaaacccg
    16021 actagccact tcctcatacc aagcctgtct ttcttgaaaa atagctacta gttcttcctt
    16081 gctattattt agaaaaagcg gtcgctgatt gtccttatca gctgcgatac gtaggtagag
    16141 ggtttcaaaa tctgctttca ggtagatgtt atctgtatta gtcttgagta agtcacgatt
    16201 tctctgagaa ataaccactc ctcctccagt tgacacgact tggtctcttt gtaataaatc
    16261 agctaggact tctgattcta cctgacgaaa ggctgcttct cccttttcag cgaaaaaatt
    16321 cgcaatggac atacctaggc gcttctcaat cagagcatcc atatcaaggt aattagggtc
    16381 caagcctctt gcaatagtcg attttccagc ccccataaac cctaataaca ccttagccat
    16441 gaatcaagct ctccaaatca tcaaagaaac taggatagct ggtattgatg gcttctgcac
    16501 ggtcaagctc cacctctcca tctgcaacca atagggctgc gatagctgtc atcatgccga
    16561 tacggtggtc accaaacgta ttgactctag caccgtgaag agctgatttt cctttgataa
    16621 tcatcccatc tgccgtagga gtaatatctg ctcccatact atttaaggcg tctgccacaa
    16681 cctgaatacg gtctgtttcc ttgaccttga gctcctcagc atccttgata actgttacac
    16741 cttgggcttg ggtcgcaagt agggcaataa taggcaattc atcaatcaaa cgtggaatca
    16801 aagcgccaca aatctctgtt cctttcaagt cagaagactc aacaatcaag gttgcagatt
    16861 tagcgactgg atcgatttca gttatttcca attttccacc catggcacga atgacatcaa
    16921 taataccggt gcgagtttcg tttatcccca cattctgcag cactagacga gaatttggag
    16981 caatcaaacc tgcgactaac caaaaggctg cactggaaat atctcctggt acgaccacct
    17041 tctgtcctgt caatttttgt ggcccttgga ctgtgatttt cttaccatcc acacttaaat
    17101 gaccaccaaa ttgttgcaac atatcttcag tatgattacg ggtgtactct ttttcgataa
    17161 taactgactc ccccttagct tgtaaggctg caaacatcaa ggctgacttg acttgggcag
    17221 aggcaattgg caactcataa tgaataggtc ttaggttttt cgtccctttt aagcgaaggg
    17281 gaggcaagtc tcgttcagtt tgccctgaga tgctgacgcc catttttttc agtggaaggg
    17341 tcacacggtc cataggacgt ttggaaagac tatcatctcc aaacatctct acttcgaaat
    17401 ctgcaccagc aaggacacct gaaatcaggc gaatcgaggt gccagaattt cccatattaa
    17461 gggcattttg cggcgctttt aagccagcca tgcctacacc ttgaacggta ataaccccat
    17521 ctttatcctc aatttcaaca ccaaggtcac gaaaaacctg catggtcgaa agaacgtctt
    17581 cacctcgcag aatatcataa accttggtct caccctcagc caaacttcca aagataatgg
    17641 aacggtggct gatagacttg tcacctggga cgcggatact accatgtaaa tggcgaatgt
    17701 ttgtttttag tttcatactg gacctcatac ttgcaatact tttacctatt ttatcataaa
    17761 aagccagaaa ttccttaaaa attcctgact ttaggatagt tcttttctta tttcagcaat
    17821 tctgaaactg gttcgaaaac aattttttca atgtcagaaa ggtaaatggc caattgttgt
    17881 tgcttggtaa agaattctga caagaggcta tttccttgaa tctgtttacc aaagccttcc
    17941 atcttagctt ggaaggacgc atctggcatt tgacctgtct gtgctagttt ttgaatttcc
    18001 tcttgaaagg caagatattc tgtaaagatt ttgcttgcct cagcatctgc tgcaatcgca
    18061 tctttagctg ctttaacagc cttgtattct ggtaatccgc gtagaccgcg actgagttcg
    18121 tttgcactat cgtaaatatt tgacatgttc ttctccttat ttaatgacga ctgtatagtc
    18181 ggtatttttt gttatgagat gctcggctct ttccaagtct tgagcatttt taaatgaaat
    18241 ttgtaggatt ccgtgaatat cctcacgatt ttcctcgttg atgtggatgt taaccaagga
    18301 agtcccacgt agcagttcca aaatccgcag gatgacatct tcttcatcag gaacgtcaac
    18361 atagaggtcg taagagctat ccacaccacc acgcttatgg atttccatgg tctggcgttg
    18421 ttcacgcgct tggttaaaaa agttccaaat ttgctcttca tctcccttac taatggcctg
    18481 accaatcgct tccaaacgtt ccttgaaatc ctcaattcta tccagaatgg tctcgctatt
    18541 ggacaagaga atggaggtcc acattcctgg ctcgctttcc gcaattcggg tcatatctcg
    18601 aaaaccacct gccgcaaagc gccttgccat ctcatgctct tgagcataga ccgcagtctg
    18661 ctccatgaga ctagaagcca aaatatgagg aaaatggcta atctgagaag tgacacgatc
    18721 atgctccttg gcatcaatct cgataaaacg agcatgaaga cctgaaagca gatccttcat
    18781 ttccttaagc gtgtcctgac ttgtcaggct tgaaggtgta aagatataat aggcattttc
    18841 aaaaagattg acatctgccg aagcagcccc tgtcttgtga ctaccagcca tgggatgggc
    18901 cccgacaaag cgaacagact tgccagccaa atactgctcc gccgcatcca caatggttga
    18961 cttggtcgaa ccagcatctg aaataataac gccttctcgc aaatccaaat tggccaactc
    19021 cttaatgaaa gcaatagttt gtttgattgg caagctgagg ataatgacat ctgccaaagg
    19081 agcaaaacta gcaaaatcat ccgttgcacg gtcaatcatg ccttctttca aggcgatgtc
    19141 tctcgaagct tgactacgat tataacctaa aatttcataa tctggatgat cgcgtttgat
    19201 accaagtgcc atagaggctc caatcaaccc aagacctgcg atatagattg tttttgccat
    19261 aggaactcct taatagttct ttgtatagtc tcggtgtttg gctaccgctt cttttagttc
    19321 ctcaagatta tctgatgaga atttttcgag gatttcttgc gccagaaccg ttgctacaac
    19381 tgcttccatg accattcctg cagctggaag agcagtcgga tcacttctct ccacggttgc
    19441 cttgtaaggt tcgtgggttt cgatatccac actcataaga ggtttataaa gagtaggaat
    19501 gggtttcata accccacgaa caacgatggg ttgcccatta gtcataccac cttcaaaacc
    19561 acctagatta ttggtacggc gagtataacc gtcttcttta gaccagagaa tttcatccat
    19621 aacttggctg cctttacgat aaccagcctc aaagccaaga ccaaattcca cccctttaaa
    19681 ggcattgata gagacaacag cttgagccaa tcttgcatcc aattttctat cccattggac
    19741 ataggaacca agaccaactg gaacgcctcc gacgactgtc tccacaaccc caccgatggt
    19801 atcaccatca cgtttgattt ggtcaatata gtccttgatt tcctgttctc gttcttggtt
    19861 gacaatagaa acttcagact gggcagctct ttgcttaatt tcagcgactg tcagattttc
    19921 aggaacatcg atttccttgc caccaaagac cacgacatgg ttggcaatct ccatatccag
    19981 ctcagccaag agacgtttgg ctactgcacc aactgccacc cgcatggtgg tttcacgagc
    20041 tgatgaacgc tccaaagaat ttcgcaaatc atcaaaacgg tacttaatcc ccccaaccaa
    20101 atcggcatga cctgggcgag gatgagtaat tttccgcttg cttttaaggc ggtcttcaat
    20161 gtcctccgca gacatgatgt ccagccattt ctggtggtcc ttattgatga catccatagt
    20221 aataggcgcc cctgtcgtct tcccgtggcg aacgcccgaa gtaaagacaa cctggtcact
    20281 ctcaatcttc atacgaccac cacgaccgta gccaccctga cggcgtctaa ggtcctcatt
    20341 gatatcctca gctgtcaatg gaagtccagc tggaattccc tcaataatag ctgttagacg
    20401 ggggccgtgt gattctcctg cagttaaata tctcatacac tctccttatt ttaccaagta
    20461 gtctttcatc tcttccagag aaactggatg aatggtcgct gaaccaagct ctggcaccaa
    20521 gaccaatttc aaggtgttac cacgcgcttt cttgtcatga gtaagagcct gataaagctt
    20581 gtcaacttcc caattttcat agtcaacagg caagccgaat ttctgacaca tctctgtgat
    20641 agattgggta atgccagctg gcatgaggcc tttttcctca gcaatcttgg aaatctgtac
    20701 cattcccatg gcaacagcct ctccatgcat gaccttgcca taaccggcag tcgcttcgat
    20761 ggcatggcca atagtgtggc caaaattgag gtaaagacga ataccattgt ccaactcatc
    20821 ttcaaccacc atcttgcgct tcacctgaca agaatgttca atcaaggtct ctgcatgttc
    20881 caaaatgctc tcaacagaac cattcagccc cgtcaagaga gcccacagtt ctggatcctc
    20941 aatcaagcca tacttgataa cttcacccat cccttcaatc aactctcttt ttccgagggt
    21001 ttcaagaaca agtggatcaa tcagaacccc atctggttgg gcaaaggtcc ccaccatatt
    21061 tttagcaaat ggtgtgttaa cgcctgtctt tccaccgata gaagaatcaa cctgagctgt
    21121 caaactagtc ggaatctgaa caaagtgaat accccgcata taggtagagg ctacaaatcc
    21181 agccaggtcc ccaacaacgc caccaccaag agcaacgatt ccatcgctac gagtcagacc
    21241 ttgcttgact agaaattcat agactttctg aacagtagtt aaattctttc tttcttcacc
    21301 ttctaagaaa tcaaaaacag ctacctgaaa accagcatct tctaggctga gcttgacctt
    21361 ctctgcatag agagaggcta catggttatc tgtcacaatg actacctttt gcggttgcca
    21421 gagttctcgc aaccactgac cagcctgggc catacaacct ttttcaatct gaatatcata
    21481 aggatgatga ggaatatcga ttctgatttt cataggagag tctccctttc tttattggta
    21541 tttttctgtt aaagactgcc aaatctcttc tgtcggcatt tccttgcctg tccacagttg
    21601 aaaagcttct gcagcttgat agagcaacat tcccagacca ttgactgctg gattgccctg
    21661 acttctagcc catttcaaaa acggtgtttc aaagggttgg tatatgatat ctgcaactaa
    21721 gagagtttct ggtaagacta tgttttcagg aacaggagag gattggccat ccatgcccac
    21781 actggtggca ttaactagca aatccgactc ggcaatcctt gcttgcagtt cagaaacata
    21841 ctctaaagca cacaaatcca ctttaaaacc tgtctgctcc tgtaacttgt ctaggtaagg
    21901 tcttgttttt tccatagaaa cggaacgaac aaagaccgaa atctgactga cgccatccaa
    21961 aatagcctgt gccaagattg atttagccgc accacctgca cccagcaggg tcatcttttt
    22021 acctgaaatt gtaaaagaag gcaagcactt aaaaaatccc ttgccatctg tattatatcc
    22081 aattaaattg ccattctcat tgacaaccgt attaaccgca ccaatcaagc gcgcttcatc
    22141 gctcagctta tccaaataag gaatcacctg ctccttatag ggcatggaca gattgatgcc
    22201 aaacatctgg tagcgacgaa tattggccac tgtttctgcc aagtcactcg cttcaatctc
    22261 ccaagccaca taagcaccgt tggtagctgt cgcctcaaag gctctattgt ggatgaaggg
    22321 agaaatagaa tgcttaatag gattggcaac aactgcagct aaacgtgtat agccatcaag
    22381 cttcatccaa aatctccctg atttttttca tgctagctag agaaatctgc ccaggggcac
    22441 taacctcatc cagactggca aaagaccaac tcgaaccggt cacatccgca gtgatacgag
    22501 agaccttgcc caccttaccc atagaaatgg tcacatattc ctgttcagga ttgagggttt
    22561 taaagcctcg tgtatagttc atcaagtcta agacatcctg ctccgtgtga gccatcaccg
    22621 caaccttaac aagttttgga tttaggatcg tcaactctga caagatttcc atcatgttct
    22681 caggtgtttc ttggaaatta tggtaactca aaacaagatt tgggaagtcc agcatttcct
    22741 caaaaacatc cttgtagcta tagtactcaa aatcaatata gtctggttga tagaattgcg
    22801 caacttcctt gattagatgg atatactctt ctggagaaag gtcgatttct ccaccttcgg
    22861 agcgagttcg tagcgtgaaa accaactcac ggcctgcgaa tttttcaaaa atggctggag
    22921 ctacctgcaa aatcgcttct ttaggcagat agtcggcacg ccattcaatg atgtcggcat
    22981 ccaggtacct cgtggcatcc agagcctgag cctcctctaa acttcttggc attactgaaa
    23041 cgattaattt catttactaa ccttcatact aatcaccttg aggtaattac tactttcatc
    23101 ttttttatta taggcaaaat ctgctggaag accatatttg tttaaaatct ggtaacttct
    23161 tcctgcaaag cctttatcaa tttgttctgt aaatttctga cgggaaacat tggcagcatt
    23221 ggtactggca atgataatcc ctcccggatt taaaatctca agactctggg aaatcaactt
    23281 gtgataatcc ttggccacag agaaagtttg ttttttattc cgagcaaagc taggcggatc
    23341 taggacaatc acatcgtagg tcaagtcttt gcgtttggca tatttgaaat actcaaagac
    23401 atccatgact ataaaacgat gctcgtctgt gctgagccca tttgcctgaa aatgcgcttg
    23461 agacaattct cgtgaacgtt tggctagatc aacagaagtt gtctggctag ctcctcccat
    23521 ggccgcagct actgaaaaag ccgctgtgta ggaaaacata ttgagcaagg atttacccat
    23581 agtcaagccg tcaactaaac taccgcgaac ctcatgctgg tctaggaaaa ttcctgtcat
    23641 caagccatca ttcataaaga cttgatacag gacaccattt tctaaaacag tgaaaaagtc
    23701 aggtgcttct tgaccataaa catgggcaga ttcatagtcc aaacctttaa agcggatttt
    23761 ctcataagcc cctaaaacct cagggaaaac ctgtctaaag gcttctgata tagtctgacg
    23821 aatctgataa acataagagt tataccaaga aaagacggcg tagttgccat aaaggtccac
    23881 tgtcagaccc ccaaagccat ctccctcttg attaaagaga cgataggtag ttgttaaatc
    23941 atcttgatag taggcgcttc tcttttcttt ggcttttcta aacaacgttt caaagaaagc
    24001 ttgattgaag gccaccttgt ctttgctgac aaaccagccc aagcccttgt tttgctgaga
    24061 aaggtaggca gtcccaagaa agtttccttc ctgaccctgc acctctactt cctgatcctt
    24121 aagattgaca ttctcaagat cactggcttc tagtaaaact agccccttag caagcttctt
    24181 ttcaaccctt ttgctgactc ttattctatt cataactacc attatatcaa acttttagac
    24241 aattctcaaa aaagaaacta cccttgcttt tttactcttc ttttaaaaaa tggtatacta
    24301 gacttcctgc aaaactagga agtaaatgtg taagaatcac aataaaaaat gctcttccgt
    24361 cttggaggag catttttttt atcaacgaaa atcaaatagc aaactatgaa actagcctca
    24421 ggttaactgt gagattatag gtagagaggt tgtatcagca atatgtgtct gtcaaattta
    24481 gtgacaaagg tagtagaaga aagatgaaga aataaatcag cttcagtaga tatctggaaa
    24541 atttgatttt atagagaagc cttttgttac aaactcaata tactatcaat aaataatatt
    24601 atagaagcaa caataattat aatttcacct atctgcatca ttctatttcg aattctaaat
    24661 atatgttcta tcaagaatac ttggaacaca cacattatag gaattaacgt ttttgaaatt
    24721 gaaaaatatc caaataaata aactataaac aacaaaaata gaactatgtt atatttctta
    24781 ttcaaaacat tcctccctat atttttgatt accaatctta atcatttaca actacattct
    24841 aacaaactat aaaagcgttt gtcgaattga atttatcaag caagcgacca accagctcat
    24901 cttttttcta tttctgccaa tatgcgtgac aggtaataat gatagccaaa aatagcaaga
    24961 gcaagcagga ggataagagc tcctactccc aagctgatgg caaggatagt ggagagagac
    25021 tgaaccaaga atatgctccc aattacaagg gccatcagga ttgcactata aataaacaat
    25081 aaaactatgg cgactatgcc atttgaacga ttcaccaggt ccgtaatgct actccaattg
    25141 gttgacagat ttttaacgtc cttaaagtaa tggtggcaag aaaggatgac actggcaagg
    25201 atccatgcca caataaggta aatcatcgaa atgatgggca agcctagata tagagaaaga
    25261 ccaagcaaag tcagaactgg taaaaaggac tggacagcat atataatcca aaatttcact
    25321 ttcacataac gagcaaagtc aaagggtaaa ctcttaagaa aatcaacatt ttccctctcc
    25381 aaggacaagg caattgaatg caggctggtg atattgttat tgacaactgc tataaagaga
    25441 gctataaaaa acaagggtaa ccagtatgga ggatgaatgt ctggaactat ctgagaatct
    25501 cggattttgg aaatcagacc gatcatcatg agataaggaa agaaagcact tgtaaaaagc
    25561 actgtaacca cgccagtccc ctgtcccaag agggtgaggt ggtagcgtaa aaccatgcga
    25621 aaaaatccct ttttagtggt tgaaattctc tccttgctgc gacgttcttt tttgacctta
    25681 tcctcactat taagcaggat cacgtcataa aaacgaggaa ggaccttctt tttggtcaga
    25741 taaagcagga agagagttag tcctatccaa gcgagcagac ccactaaggc ttctgtcgaa
    25801 aaaggctcca ctgctatttt gtaaaagata tgaagaggat aaaggagaaa tggaatgtct
    25861 ctaactttgt caacaatact tccaaaagtc gactgaagaa agaagataaa tattaaaggt
    25921 atgagaactc ctatcccaat catcacattc gaaaaaatag accgatactt tctgaagacc
    25981 ctagtctgag ccaagaaatg tactgccact accatcacta aagtaacaga gacaaataat
    26041 aaggtcaagg acagtagcat caaaggcaaa cccaaccaca gagaaggtgc tagcctaatg
    26101 tagaggacca gaaaataagc taggattggt acaattccag ctagagctgg caagaggaca
    26161 gacagacctt tggccattat aatctctgat tctttaaagg catagggcct ataggaggcc
    26221 aggtccttac tctcataaaa gacattgtaa aatgcagtga aagaagttga aaaggccagc
    26281 accagtaaaa tagcaaccat cgtactaaaa aaacttggca tttcctcaaa aggaaaacga
    26341 aaggctatat ttataaacat gaaaagcatc aagagactag aaaaaatgta agaacttagg
    26401 actctagcgg aaacatttac ttttttccca ggattcttag cctgcttctt tcgtagatta
    26461 gccagattag cttcttgaga tgaatagagg atattgatat caactaattt tttaatgacc
    26521 ttgagacgca tccgcaacct cctcttttct accagcaaga ctaaggtaga tactttccaa
    26581 agactggtct gggtggtctt tcctcaagtt ctctacacta ccacaataga tcaaatgccc
    26641 ctttttcaaa atggcaatcc gattacagac ttgctcggct acctctagga catgagttga
    26701 aaacaagacc gtcttccctt tttgtgcatg ttccttcatc atctgtttca aatcaaaggc
    26761 agcctgggga tccaaaccag tcaagggttc gtccaagacc caaatatcag gatcagacaa
    26821 gagtgccccg atgacaaaaa ctttctgacg cattccatga gaaagggttt caataacctg
    26881 ataacgattt tcagcaaaat caaaaacgtt caatagccta gctagactag cctccaagtc
    26941 agatctactc agatcatagg atgaggcgat caattcccaa aattcattgg ccgttaagcg
    27001 taaaaataag tcaggcgagt ctgctacgta gccaatcttt cgtttaatag ccaagcgatt
    27061 ttccgataac tcctgaccgt ctaccaaaat acgaccactg ctgggtgaaa tgatactgac
    27121 tagggatttt atggtggtcg attttccagc cccattatga ccaatcaagc ccataatctc
    27181 tccattttca atctgcaaat tgagattact caaggcctct ttatcaccat acaacttact
    27241 aacattttga aattcaatca tgggacaact cctatcttta tctgtattat acatcgctat
    27301 actagcactt tgatacaaaa aaatcaatac tttattttaa gtagttaaaa tagtttcctt
    27361 ctatcttacg caaacgtttg cgccaagaga tactttatga tagaataaag aacaagattg
    27421 acaagtaaga ggaaacatca tgcaaaatca aacactcatg caatactttg aatggtatct
    27481 gccccacgac ggtcaacact ggacgcgtct ggctgaaaat gctccacacc tagctcatct
    27541 ggggatcagt cacgtctgga tgccaccagc cttcaaggca accaacgaaa aagatgtcgg
    27601 ctatggggtc tatgacttat ttgacttagg agagttcaac caaaaaggga ctgtccgcac
    27661 caagtatggt ttcaaagaag actatcttca agccattcaa gcccttaaag cacagggaat
    27721 tcaacctatg gccgatgtag ttctcaacca caaggctgct gccgatcaca gggaagcctt
    27781 tcaggtcatc gaagttgatc ctgtagaccg tacagttgaa cttggagaac ccttcaccat
    27841 caatggctgg actagtttta ccttcgatgg tcgccaagat acctataatg gcttccactg
    27901 gcattggtac cacttcactg gtacagacta cgatgccaaa cgcagtaaat ctgggattta
    27961 tctgatccaa ggggacaaca agggctgggc taacgaggaa ttggtcgata acgaaaacgg
    28021 aaactacgac tacctcatgt atgccgacct agactttaaa catcctgaag tcatccaaaa
    28081 catctatgac tgggctgatt ggttcatgga aacgactggt gtagctggtt tccgtttgga
    28141 tgccgttaag catattgact ctttctttat gcgcaacttc atccgcgata tgaaggaaaa
    28201 atacggtgac gatttctatg tttttggtga attttggaac ccagacaagg aagccaatct
    28261 ggactatctc gaaaaaacgg aagaacactt tgaccttgtc gatgttcgtc tccaccagaa
    28321 tctctttgaa gccagtcaag ctggcgcaaa ctatgacctt cgtggcattt tcacagatag
    28381 cctggttgaa ctcaagcctg acaaggctgt gacttttgtc gacaaccacg atacccaacg
    28441 aggacaagcc cttgagtcta ccgttgaaga atggttcaag ccagcagcct atgccctcat
    28501 tttgttacgc caagacggcc ttccatgtgt cttttacgga gactactatg ggatttcagg
    28561 ccagtatgct caagaagatt tcaaagaaat ccttgaccgc ctcctagcca tccgaaaaga
    28621 tttggcctat ggagaacaaa atgactactt tgaccatgct aactgtatcg gttgggtacg
    28681 ttcaggtgct gaaaatcaat ccccaatcgc agtccttatc tcaaatgacc aagaaaacag
    28741 caagtcaatg tttgtcggtc aagaatggac taatcaaacc tttgtagatt tacttggtaa
    28801 ccaccaaggt caagttacaa ttgatgagga aggttatgga caattccctg tctcagctag
    28861 atccgtaagt gtctgggcag tcaataccat ctaatagctc ataataacca agctaggtcc
    28921 aagcggattt ggcttttttg tattcacaaa aagacctacc caaatggata gatctttact
    28981 tgattacaat ttacctgcta ctgcatccaa caattcttgg atcttagctt ggttgcttcc
    29041 tcctgccatg gccatgtctg gtttaccacc accacgtcca tcgatgattg gtgctaattc
    29101 tttgacaagg tttcctgcat gaaggtcttt tgtcttgctt gctacaagga cattgacttt
    29161 gtcaccgata gcggcaacta ggacaagaag atcagagtag tctttttgtt tccagttatc
    29221 tgcaaaggta cgaagggcac ctgcatcgga tacagacact tgactagcaa tgtaacgatg
    29281 accgttgact tccttaacat ctttgaagat atcgcctgcg gctgcagctg cggctttttc
    29341 tttcaactca gcattttctt tttgaagttg acgaagttgt tcttgaagtc cttctacctt
    29401 gtgaggtact tccttgactt gaggtgcttt caaggttgct gcgatagctt taagagcatc
    29461 ctcttgttca cgataggctt caaaggcttc cttaccagtc actgccaaga tacggcgagt
    29521 tcctgaaccg attccttctt ctttgacaat tttgaagaga ccaatctcag aagtgttgcc
    29581 aacatgagta ccaccacaaa gttcaataga gtagtcaccg atagtcacga cacgaacttc
    29641 cttgccgtat ttctcaccaa agagggccat agctcccatt tctttagcag tgtcaatatc
    29701 cgtttcaact gtcttaactt caagagcttc ccagattttt tcgttgactt gctgttcaat
    29761 cgcacgcaat tcttcagcag ttacagcttg gaagtgggta aagtcaaagc gaaggaattc
    29821 aacttcgtta agagatcctg cctgtgttgc gtggtttcca aggatattgt gaagggcagc
    29881 gtgaagcaaa tgagtcgcag tgtggttttt catgacacgg tgacggcgat tgctatcaat
    29941 tgccaaggta tattcttggt tcaaggcaag cggtgcaagg acttcaactg tatgaagggc
    30001 ttgaccattt ggggctttct gaacattggt cacagtagcc acaaccttac ctgactcatc
    30061 caagatttgt ccgtggtcag cgacctgtcc acccatttca gcatagaatg gcgtttccgc
    30121 aaagataagt gaggtagttc cttctgatac agcttctact tctgcattgt ccgccacgat
    30181 agctaccaat ttagaagaca attggctagc attgtggttg aagacacttt ctacagtgat
    30241 gttttgaaga gtttcatttt gcatacccat tgagccaccc ttgacagctg acgcacgcgc
    30301 gcgttcttgt tgttctttca tggctgcttc aaaaccttca cggtctacag tcataccagc
    30361 ctcttcagca atttcttcag tcaattcaac tgggaatccg tatgtatcat agagtttaaa
    30421 gacatcttga ccagcaatga cagattgacc tttttctttc aagtctgcca caatgccttg
    30481 ggcaaagtgt tgacctgagt gaagggtacg ggcaaatgat tcttcttcgc tcttaacgat
    30541 tttctcaata aagtcacgtt tctcaagcac ttctgggtag tagctttcca tgatgtttcc
    30601 aacagttgga acgagtttgt aaaggaaagg ctcgttgata cccaattttt gaccatgcat
    30661 agaagcacga cggagaagac gacgaagaac ataaccacga ccttcatttc ctggaagggc
    30721 accatcaccg atggcaaatg aaagtgaacg gatgtggtca gcgatgacct tgaagctcat
    30781 gttgtcgcca tcttggtcat aaaccttacc agacaatttc tcgacttcac ggataatcgg
    30841 catgaagagg tccgtttcaa agttggtctt agccccttgg gtaacggcca ccaaacgctc
    30901 caaaccagcg cccgtatcaa tgttcttatg tggcaattcc ttgtattcgc tacgaggaac
    30961 agcagggtct gcgttaaatt gtgacaaaac gatgttccag atttcaatat aacggtcgtt
    31021 ttcaatatct tctgcaagca ggcgaagacc gatattttct gggtcaaagg cttccccacg
    31081 gtcaaagaag atttctgtat ctggtccaga aggtcccgca ccgatttccc agaagttgtc
    31141 ctcaattgga atcaagtgac ttggatccac tcccacttca atccagcggt tgtaagaatc
    31201 tttatcgtct ggatagtagg tcatgtaaag tttttcagca gggaaatcaa accattcagg
    31261 gcttgtcaaa agctcataag cccaagtgat agcttcgtca cggaagtaat ccccgataga
    31321 gaagttcccc aacatttcaa acatggtatg gtgacgcgca gtcttcccta cgttttcgat
    31381 gtcgttggta cggatagcct tttgggcatt ggtaatacgt ggattttcag ggataatggt
    31441 cccgtcaaag tatttcttaa gggttgctac cccagagttg atccacaaaa gagttgggtc
    31501 atttacagga accaaactta ctgatggttc tactgagtga cctttggtcg cccagaaatc
    31561 aagccacatt tggcgtactt gtgcactaga tagttgtttc atattgtctc cttatttact
    31621 tgtttaatgt gattggcttt ccagcatttc cacatagtca atcgcgacac agagggaaat
    31681 gactaggtct gcataagcgt cttcaagaac cgttacggta taggtagagg tcagatggaa
    31741 gagttccttc ttaatttccg caatcaactg atcgcgatca tccagcaatt tgaaattcaa
    31801 atcccagata ttgccctcga tacgaagacc tagattatca aactcatact tatctcgcca
    31861 gaaggtcaac ttcttacgaa tgacaaaact cgagccatcc cgaagctgaa tctcaaaacg
    31921 aggaagcaag gtcaagattt ctttactaat ctcactgact tgttcaccag ccgcatcata
    31981 gatggtaaag gttttaggaa tcttaaaaaa tgatccctcc acctgatagg caatttctcc
    32041 cctgtcatcc ttgatagcga agcgttcgcc tccaagacga aacttttgtt tgacaagaaa
    32101 tgttttcatc aacacctcca aaaatcaaaa gacaagctca tatcacgaag ggcgaaaaac
    32161 cgcggtacca ccttcattca atgaacttgt cattctcttg ttcttatgca attgtatgat
    32221 tgagcagcat gacttcctag cttagatggc tcgcagcacc gccatttctc tggactaaga
    32281 caagtgaaaa tcaattctca actttcttat tataacgttt ttttaagctt gcgtcaactg
    32341 gaaatgatct ccgttgaatt agaccaattc cctacatctc tgattacttt ttcaggatat
    32401 attttttctt actgccgttt ttctttttat cccaaatttt catattacta aacacagcta
    32461 ctagaatatt tccaaatata aaggtgccta tcacccaata tatggactca gttgttaggt
    32521 attgtcgatc caagccatcc tttaaatgga atagtatagc agtttggtta acaatcataa
    32581 aggttggcca gaaacttttt ttgaaaaaag tagacatttt cattatttgt tgccgctttc
    32641 tgtaaggtta atactcaata aaaatcaaaa agcaaactag gaagctagcc tcaagctgta
    32701 cttgagtacg gcaaggcaac gctgacgtgg tttgaagagt ataggcttag tatactacta
    32761 ggcaagcaaa taagcaaata agcaaataaa caaataaaca actagaatag aaaaagatag
    32821 ggctctaaaa actgacttct attccttaaa aacgaaccag cttgactgat tcgtcttctt
    32881 acgtttatct cctacttccg atacatttta aactgtagga agaggtcgct atatttccct
    32941 gtccatttat ggtcaaattt ctcataaact tctaggtgtt tcatggtttc aacatcggga
    33001 tagaaggcct tatcttcctt tgtttcctct gggagcaatt ccttcgctgg taggtttggt
    33061 gttgaatagc cgacatactc cgcattttgg agagcatttt caggtttcaa cataaagttg
    33121 ataaaggcat aggctgagtt ttggttttta actgttttgg gaatgaccat attgtcaaac
    33181 caaagattgc tggcctctgt cggtaccaca taacgtagat tttcattttt ttctaacatt
    33241 tggctggctt caccagagaa ggtcacgccg attgcaacat tattctgaat catatagccc
    33301 ttcatctcgt ccgcaacgat agccttgata tttggagtca gtttgtagag cttatccact
    33361 gtctcttcca actgctgcag atccttggag ttgagactgt agccgaggga attgagtcct
    33421 agtcccagca cctcacgcgc cccatcaaag agcatgatag aattcttata ctccggcttc
    33481 caaaggtcat cccaatgctc aggcgcttca tctaccatgg tttcgttgta gacaattcct
    33541 aaggttcccc agaagtaagg gatggagaat ttattacctg ggtcaaagga ctggttgaga
    33601 aactctggtc cgatattttc gattccttca atttttgaat aatcaagcgg aaccaagagg
    33661 tcttcgtcct tcatcttgtt aatcatgtat tcacttggaa tggcaatatc gtaggtcgtt
    33721 ccaccctgct ttatcttagt gtacatggct tcgttggagt caaaagtctc gtactgaact
    33781 tgaattcctg tttcttctgt aaactgagtc aagagttcag gatcgatata gtctccccag
    33841 ttatagataa ccaatttttg actatctcga ctattgattt tactatctaa atgagtcgca
    33901 attccccaca agacaaggat aatcgctgca attcctgcta aaaatgaata gatttttttc
    33961 atgcttgctc ctccttctca cgagagataa agtaataacc tacaactagg ataatactaa
    34021 agagaaagac tagagcagac agggcattga tttctaagga aatccccttg cgagcacgag
    34081 agtaaatctc gactgatagg gttgaaaagc catttcctgt tacaaagaag gtcacggcaa
    34141 agtcatctaa cgaataggtg aaggccatga aataaccagt aatgatagac ggagtcaggt
    34201 aaggaagcat gatttccttg aacatctgaa attgactagc tcccaagtca taggccgcat
    34261 gaatcatgtc gccattcatt tccttgagtc gaggcaagac catcaagacc acgataggaa
    34321 tggagaaggc cacgtgacta gatagaacgg tcaaaaagcc aagtgaaaac ttgagttggg
    34381 taaagagaat caagaagcta gcaccaatca taacgtcagg cgcaaccatg aggatattat
    34441 tgagtgatag aaaggcttct tggtatttct tacgagactg gtagatgtaa atggcaccaa
    34501 aagtcccgat aatggtcgct atcaaagctg ataggaaggc caagaaaaat gtctgagcca
    34561 aaatcagcat gagtctccca tctccaaaca tggtttcaaa gtgagtccag ctaaaacctg
    34621 taaagctatt catatcatca ccagcattaa aggcatagcc aatcaagtaa aagataggca
    34681 ggtagaggac cagaaagacc agtcccagat aaaggttggc aaattttttc atcgttctct
    34741 cctttcctta gtcacccaca tggtgatgaa catggtcagg atgagaatca caccgatggt
    34801 tgaacccata ccatagttgt cattggttag aaaattctgc tcaatagccg tccccaaggt
    34861 gataacgcgg ttcccaccaa tcaaacgggt cagcatgaag agactcaaac ttgggataaa
    34921 gaccgactga accccacttc gcacaccgtt catagataga gggaagatga catgacggaa
    34981 ggtctcccac ttagttgcac caaggtcata actagcattg atgagattat tatccatatc
    35041 gtctaagaca ttgaaaatcg gcaaaatcat aaaggggagc tcgatgtagc ttgcgacaaa
    35101 gataaaggaa aaatcggtaa aaagcaactg ttgtgaacca attccgataa attccaagaa
    35161 ttggttaata gagccatttt gaccaaaaat cccgataaaa gcataggctt taaggagcaa
    35221 attgatccag gtaggaagga taatcagcat gagccagagt tgacggtgct tgagacgggt
    35281 caaaaagagg gctgttggat agctgataag caaggtcaca aaggtcacaa tgcctgcata
    35341 aagcactgag ttgaaactca ttttgaggta ggtcaagttt tgtgacgcaa agtaagattt
    35401 ataattttct aaactaaact ggccttcaat gttgaaaaag gattgtccga aaatcaagac
    35461 caagggtgcc aatacaaaga gggcaatcca aagcatgtag ggcactacaa agagtttaga
    35521 gcttgttttc ttcatctctt tcctcctcga tcgcattgat cagacctgct tcttgctctt
    35581 cgatttccac gtattcttcg atacgagcat cgaactcttc ttcggtttca ttgagacgca
    35641 tgatgtggat gtcttctgat tcaaagtcca gaccgatttc ctcacccacg atggccttac
    35701 gggttgagtg gatcatccat tcatttccaa gttcgtcata ggcgataatt tcataatgaa
    35761 ctccacggaa gagctgggtg tcgaccttaa cttggagttt gccttcttca ggaagggtaa
    35821 tgcgcaagtc ctctggacga ataacgacct caacaggttc atttggcttc atcccaccat
    35881 caaccgcttc aaagcgtttg ccgttaaatt cgaccaagta gtcctcaatc atggtacctg
    35941 gcaagatgtt tgactccccg ataaaggtgg caacaaagtg gttgattggc tcatcgtaga
    36001 tgtccacagg ggttccagac tggacaatct cgccatcatt cataacgaaa atccagtcac
    36061 tcatggcaag agcttcttcc tgatcgtgag tgacaaagac aaaggtaatg cccaatcgtt
    36121 gttgtaattc acgcaattcg tactgcatgt ctgttctcaa tttcaagtcc agcgctgata
    36181 aaggctcgtc caacaagacc acacggggtt ggttgatgat agcacgggcg atggccacac
    36241 gctgacgttg tcctccagaa agtttgcgga tggaacgttt ttcataacct tccaactgaa
    36301 ccatcttgag aacttccgct acacgctgct cgatttcttt cttatcaatt ttacgcaagc
    36361 gaagtggaaa ggcaacattt tcaaacacat tcatatgtgg gaacaaggca taggattgga
    36421 agacggtatg tacgtcgcgc ttgttggttg gaatatcatt gatacgaaca ccgtctagca
    36481 tgatatctcc tgtcgtcgca tccagtaaac ctgcaataat gtttaggata gttgatttcc
    36541 ccgaaccaga tgcacctaga agggtgtaga atttcccttc ttccaactca aagttgatgt
    36601 ctttgagaac cttggtgttg ctgtcttcaa aaactttaga gacgtttttg aattcgataa
    36661 ttggtttttt caattggcat aaattccttc ttttcataga ttaaccgatc ggggctctgt
    36721 caggtcccca ctacctcttg cagggagtaa aaccacctgc atacatcttc gctaccgata
    36781 ggctttcacc caagatccgg acttctcttt caagcgtaat acctgagtgt tccttgactt
    36841 tttcgataac cgattggatc aagtcctcgt agtctttggc cgttccatct gcgacattga
    36901 tcataaatcc tgcatgcttt tctgacactt ctacgccacc gatacgatag cctttcaagc
    36961 cagcttctga aattaactga cctgcaaaat gcccgactgg acgcttaaag accgagccac
    37021 aagatgggta ttccaaaggt tgcttgagtt cacgtaggtg cgtcaagcgg tccatttcct
    37081 gcttgataac ctgatgggtt cctggagcta gggcaaattt aactgacaag acaactgcac
    37141 cagactcctg aatagctgaa tggcggtaac caaaagccaa gtctttagca gacagggttt
    37201 cgatttctcc atccttggtc aagaccttac aagactgcaa gatgtgagca atctcgccac
    37261 cataggcacc cgcattcata aagacagcac cgccaacgct tcctggaata ccacaagcaa
    37321 actcaaagcc agttaaacta tgacggaggg caatgcgagt tgtttcaatc aagttagccc
    37381 cagcttctgc ttcaatggta tagccatcaa cagaaacgtt attgagcttg tcacacaaga
    37441 tgacaaatcc acgaatccca ccatcacgaa cgatgatatt gcttgcattg ccaagaacca
    37501 tccaagggat attttcttgg ttggcaaatt tcacaacgcg agccaactca aaacgatttc
    37561 gtggaaagac caaataatca gcctctccac ctacttttgt ataactatag ctatgcaagg
    37621 gttcctgaaa acggatatca attccttcta agatttcaag cattttttct cttacagaca
    37681 tgtcactctt ccttttacaa aattcattcc attataccat ttttagagac atttgacgac
    37741 cataaaaata ccttgtttgg attttgcata agaaaaagag gtttccccct ttttatgatt
    37801 ttttacaaaa gatttccttg gttccatagg cgaccagaac gagctccagt gctagaatca
    37861 cttcaaccaa gactggattt gtcaaccagc ctacttggga aagagatggt gccagatcaa
    37921 agaaggcatg caagccatag gctgctagga gataaatcca tttcttctgg cgaacagctt
    37981 ggtaaaccca aactgtcaaa agtaattgga aaccaagcgc caagattcgc tcaaaaccaa
    38041 gcaaataaat ctgccagacc gaaagtgact gaatggtttt taacatattt tcagacagta
    38101 attgcataac ctgtggattc tgagtttgaa ctgccgaaag aacaatgtaa agattgagta
    38161 aactagtaag gcctagaaaa atcaactcca agccaccatg ccccagtcca taggccaagg
    38221 cgtctgcctt ttccaaactt ctctttttct ccaaccattt gaagaaaaca agacgagccg
    38281 tttcctcaaa aaatgctgcc atagctaggc catagataat atagacaagc gggtgatctt
    38341 gcaagagggc aatactaccg tcttttttga ggatgcaaaa tcaagatatg caccagtttt
    38401 tccaaaatct gcgaagagac aaagaaagcg actgcaccca agcccaagac agctagatta
    38461 atctggtatt tctttttggc aaaccaaatg cttcctatca gaaaagctag caacagcaac
    38521 atggtaataa tgatatgaat ggtcattttc ttctcctatt ctgccttttc aatatctttt
    38581 ttcatctcgt caacattgaa cttagcaaac aagtattgac ggtcttggac tgggaaacgt
    38641 tggtccaact ggtcaactgc tcccacctcg ataatgcctt ccttgatgac aaaatccatg
    38701 acatgtccac cgaaggtcaa atcatctgat atgaagtgca gatggtagcc tgccacactg
    38761 accccatgga aaatctcagg cgtccagaaa ccaacaatag tccccgcaac attgtcacga
    38821 ctatattccg gttgatgggt tgcgacatca gcaaacttgg tatcgggtgt tgacttagga
    38881 atcatacgca catgcatatg tgaaaattcc ccccgaatct tgatagaacg gaaaagattt
    38941 tccccatcat aataagactc aattcgttct tccaattcct tgtctgtcat ctcaaagcgc
    39001 tggcggaaaa tgacctctgc ctgatgcggt actactgctg cataaggaat aagggcatct
    39061 ggtgacactt ccacaatttc tggctgttct cctgttcctt ttgcctgata agccttgcca
    39121 tctaagacaa tcaattcccc atcaatagaa tccaaggttc ccaaaccaag gtcaccatgc
    39181 tctagcaatt ctcccactgt catggtacca ccataaaggc cagccatcaa ggctccaaga
    39241 gtattgtatt gaaataattt cactggttcc tgcacgttct tatccattca ctttcttgtc
    39301 tgttattcta taaatcttac tcctaagtat accacatttg cccctagatg tgaacgagag
    39361 aaacgctcta gacattgcca agaaggaaaa aaaagggtac aatgtaacaa aatcaaggga
    39421 ggtctggaat gaagagacaa agcaagtaca aagaggtcgt ttcctatctg aaaaatggta
    39481 tcgagtctgg acgatttccg acgggtagtc gcctgccttc tatccgtcaa ctgagccttg
    39541 actttcactg cagcaaggac accattcaac gagccctgct ggaattacgg cacgaacaat
    39601 acctctatgc caagcctcag agtggctact atgtattaga acaagggcaa catcaagacc
    39661 tagaaatcga ggttaccgac gaacatgcca gtgcctatga cgatttccga ctctgtgtca
    39721 atgaaacctt gattggccga gaaaactacc tcttcaacta ctatgacaat caagaaggat
    39781 tagaaggcct aagacagtcc attcacaaac tcctctttga gcaagctctc tactgcaagg
    39841 ctaaccaact agtactgact tctggaaccc aacaagcctt gtttatcctc tctcaaatat
    39901 cctttcctag acaagccaag gaaatcttgg tggaacagcc aacctaccat cggatgaatc
    39961 gcctcttgat tgcacagggg ctggactatc aaacgattga acgaggcatt gatgggattg
    40021 acttggagga gctggaaggc cacttcaaaa caggaaaaat taaatttttc tacaccattc
    40081 cccgatttca ctatcctctg ggacattcct attctgagca agacaaacga tctattctta
    40141 acttagctgc caagtatgat gtctatatcg tagaggacga ttatctgggt gatttggact
    40201 ccaagaaggg ccaaaccttc cactatcttg atacagagga gcgtgtcatt tatatcaagt
    40261 ccttctcgac cagccttttt cctgcccttc gtattacagc actcattctt ccaaatgcta
    40321 tcaaagaagc atttatggcc tacaaaaata tcctagacta cgacagcaac ctcattatgc
    40381 aaaaggccct gtcactctat attgacagtc aattgtttga aaaaaatcgt ttggctcgct
    40441 tgaccaatca tgaatcttac caaaaacaaa tcgaggaaag gataactaaa acaccttgtc
    40501 cccttcctca ttatccccta cacgatggtt tattgctaga cctgagacag tatcctaaaa
    40561 tcgccagtct caaacacagt caactgggct tggacttctt tgaagaggcc tatttaagca
    40621 cctgtcctta tcaatttgcc aaggtgtccc tagacaatct ggaaaatgtt ttaaactatt
    40681 taaaagcaga attggaatga catccaactc tgctttttct tattcttcaa cttcagttag
    40741 acttgctgct ttttcaagat agctttggta agttccttca tccttaagtt tttggatgac
    40801 cttgtctacc acttctttca aatcatcact attttttcta agtgcaacgg cattggcgtc
    40861 gccgtccttc atcttcaagc tgacagttgc gacagctaag ccagcgtttt tagcagcata
    40921 actaagtgca acaggctcat ccatatgaac agcatctatt tttccagcct gcaattcatt
    40981 gactgcttca cccatattag ttagggaagt taattgagct tttggcaatt gttccttgac
    41041 cattgattct ggaacagtcc ctttttgggc tgcaatatta gcactttcta ggctagttaa
    41101 atccttgtat ttttccacat cagccttacg aaccaagaaa ctaatcttgt tttcatagta
    41161 tgggattgaa aaatcaaaga cttcttttct ctcgtcagta gcactaattc ctgcaactgc
    41221 taggtcagcc ttaccagttt gaagactggt caaaacattg tcaaaactca tgcttaagat
    41281 ttccaactta accccaagtt catcagcgat agcttgagcc atgtcgatgt ctgcaccgac
    41341 tacctggttc tttccatcaa ccaatgattg aaattcaaag ggtgcatagt caggactggt
    41401 tgccacaact aatttcccct tttgcttaat ggcctcaaca gctgactgag aaccattaga
    41461 acctgactgg caagctacta agaagaaact tgcaagaaaa ttacataaaa caaatatcca
    41521 tttttttgat ttcataaata aacaaccttt ctgttaattt tgtataatta taacaatatc
    41581 caagttactt gtcaagtgtt ttttaaattt ttatctcaaa aatatttttt cgttcaaaaa
    41641 aaggagccat cagttgattt caagctcctt tttatacaga attaaactat tttatagttc
    41701 gacaatctta cctgtttcaa agtagacaac ccattcacag atatttttag catagtcacc
    41761 gatacgctcc aagtaggaaa taacttggaa ataatcacga cccgtaacaa tggcttctgg
    41821 atttttctta atctcttcag tcgcaaggtc acggatagtt tcaaaatagt ggttaatttg
    41881 ctcatccatg gaggccaccc ggtatgcgtc gtcaacagaa ccattaagat aaagatcaag
    41941 tgctgcttca acaacgcttt taacttcacg tcccattttt ttaatttctt cctctacagc
    42001 tgggatgcgt tcttccccct tcatacggat ggttgcctgg gcaatggcta cagcgtgatc
    42061 ccccatacgc tccacatctg atacagcctt aaggacagtc aagactgtac gcaaatcttg
    42121 agagactggt tgttggagtg cgatcatttc aaatgatttc ttttccagtt tcacttcgta
    42181 ttcatttact tctgcatcat cttctatgac ctcttttgcc aggtcacggt catgcgtgac
    42241 aaaagcacgt accgtacgat tgatttgtga gagcacttct tgtcccatag cgtagaactg
    42301 gttatgtaat ttctctaaat cttcttcaaa ttgagatcgt aacatctttc atctccttat
    42361 ccaaattttc ctgtaatata gtcttccgtt tccttgtgtt ggggatcaag gaacatctgc
    42421 ttggtatcat taaattcaat caaatctcca tctaggaaaa atcctgtctt atcagagata
    42481 cgtgaagctt gctgcatgga acgggttacc agaagcatgg tgtacttgtc ttttagacca
    42541 tacaaggttt cctcaatttt accagctgaa atcggatcca aagccgaagt tggctcatcc
    42601 aagaggatga ttttaggact agttgccaag acacgggcca cgcagacacg ctgctgttga
    42661 ccacctgaca atccaatagc tgaatcatat agacgatcct tgacctcatc ccagatagag
    42721 gcaccttgca aggctttttc tacggcttca tccagaacct gcttatcctt aattccattg
    42781 atacgaagcc cgtagacaac attctcatag atagtcatag ggaaaggatt aggttgttgg
    42841 aaaaccattc cgatttcctt acgtaattca accgtatctg tacgcggact gtagatgttg
    42901 tgaccattgt acaccacgga tccagttgtg gtcacctctg gattgagatc tcccatgcgg
    42961 ttgagagact tgaggagggt tgacttccct gatccagatg gaccaatcaa ggctgtaatt
    43021 tccttaggtt ggaaagatag ggaaacacta ttcaaagcct tctttttatt ataataaacg
    43081 gacaggtctg atacctgtaa aatcgcatct gtcatacggt ttcctttcta accaaagtga
    43141 ccagatacat agtcattggt ggactgtagc ttggcatttt ggaaaatagt tgcagtcttg
    43201 tcatactcaa tcaaatcacc caagtaaaag aagcctgtat agtcacttgc acgagcagcc
    43261 tgctgcatat tatgcgttac aatgatgatg gtaaagtttt tcttgagctc aaacatggtc
    43321 tcttctagtt gcatggtcgc aatcggatcc aaggctgagg ctggctcatc cattaagagg
    43381 atatctggct taacagagat ggcacgagcg atacagagac gttgttgctg accacctgat
    43441 aaggtcaagg ctgacttgtg gagatcgtct ttaacctgat cccagagggc agcctgacga
    43501 agggaggttt ctacgatttc atctaggact tgcttatcct taactccagc acgttcatgc
    43561 gcaaaggtaa tattacggta aattgactta gcaaatggat tggggcgttg aaaaaccatt
    43621 ccaatgtgtt tacgcatttc ataaacgttg atttctggac ggttgacatc aattccacga
    43681 tagagaatct gcccagttac tttagcaata tcaatagtat cattcatgcg attgagactg
    43741 cgtaagtagg tagatttccc cgaccccgac ggaccaatca aagctgtaat tttatttctt
    43801 tcaaattgca tatcaatccc cttaatggat tcatttttac catagtaaac atggacatcc
    43861 ttagtagaaa gggctacttt ttcttcagga aaggtaagga tatgcttctc atcccagtta
    43921 tatgttgaca tggcttctcc tttaggcagc ggttaatttc ttgtgtagat agcttccgaa
    43981 cttacgagct ccaaagttaa aaatcaggat aaagatcagg agcacagcgg cagaacctgc
    44041 tgatacaatg gttccatctg gaatagtgcc ttcactattg actttccaga tatggacagc
    44101 caaggtttct gcttgacgga agatagagat ggggctagtc acactgagga tattccagtt
    44161 agaccagtca agagctggcg ccgattgccc tgctgtatag atcagagctg cagcttcgcc
    44221 aaagatacga ccagatgcca agacgacacc cgttacaata cctggaagcg cttctggaat
    44281 aacaacatga accactgtct cccagcgaga aatcccaaga gccagaccag cctcacgttg
    44341 ggtatggtga acgtgtttca aactatcctc tacattacgc gtcatctgag gcaaattaaa
    44401 gactgtcaag gccaaggcac ctgaaatgat tgaaaatcca tactcaaact ggactacaaa
    44461 gatcaagtaa ccaaagagac ccaccaccac tgatggtaaa gaggacaaga tttcaataca
    44521 agtccgcaca aagttggtaa caggaccttt tttagcatat tcagccaagt agatcccagc
    44581 tcccatagaa agaggtacag aaataatcaa ggtaatgacc aataggaaaa aggaattgta
    44641 aagctgaatg ccaatcccac cacctgcttg aaaagcagaa gaccttccag tcaagaaaga
    44701 ccaagagata tggggcaagc cccgaaccaa gatatagaga atcaaggaag ccaagattgt
    44761 cacaatgatg ctagcaatcg tatagaggac agctgttgca agtttatcta atttcttagc
    44821 gcgcataatt tttctttcct ctttctttcg taatcaattt aatcacactg ttaaaaacta
    44881 agctcatcaa gagcagtacc aaggccagtg accagagaac attattattt acagttccca
    44941 tgacagtgtt cccaattccc atagttaata tagaagttaa agttgcagct ggtgtggtca
    45001 aggaagttgg gataacagct gagtttccga caaccatctg gatagctaga gcctcaccaa
    45061 aggcacgcgc catcccaaag accactgcag tgaaaatacc agaacgggcc gccttcaaga
    45121 tcacacgcca gatagtctgc cagcgagtgg ctcccatagc gaaactagcc tcacgataat
    45181 aacgaggaac cgcacgcaag ctatccgttg tcataaaggt tacggtcggc aaaatcatga
    45241 caaagaggac ggaaatccct gacaaaatcc caaaaccagt cccaccaaag acactgcgaa
    45301 caaagggaac gacgacttgc aagccaataa atccgtacac tactgaagga atcccaacca
    45361 ggagttcaat agctggttgc aaaatcttcg ccccttttgg tgatacttcg gtcataaaaa
    45421 ctgctgcacc aatagcaaag ggtgttgcga taagggctga gagaatggta acgataaagg
    45481 aacccaaaat cataggaagg gcaccaaatt ctttactaga aggattccaa gttcctccca
    45541 aaagaaagtc aaagatattc acaccattga caaagaaggt cgacaagcct ttttgcgcta
    45601 cgaaaaccaa aatcatggcc acaaggatga ctatcaaaga aagacaggca aaggtcaaac
    45661 cttttcctaa tttctccaga cgagaattct ttgatggaag caacattttc ttagctaatt
    45721 cttcttgatt cattattgtc tcccttccaa cactgtcaca gttccggcag catctttttc
    45781 aaccttcatt tccttaatcg gaatatactt caatcctttg acaatccctt cttgggtctc
    45841 atccgagaga acaaaattga gaaattctgc agccaactca ttgggctgcc ccaatgtata
    45901 catatgctca taagaccaca agggccaatt attgctactt atattttctg gacttaagtc
    45961 atagccattc aacttcatgc ttttgaccga atcatctata taggtaagag ataaataaga
    46021 gatagctcct ggactttttg atacgattga ttttaccgct ccatttgaat cctgctcctg
    46081 actttgcatg gcagactgac cttccataat gacagtatca aaggtagcac gagagccaga
    46141 gccggctgcc cgattgataa cagagatggg taagtcctta ccaccaacct ctttccaatt
    46201 ggttacctca cctatgaaga tttgacgaag ttgctctgtc gttaggttat caacatcaac
    46261 ctccttattg acaatcagag ccaagccagc taccgcgacc ttgtggtcaa caagagcaga
    46321 agcatcaatt ccgtcttttt cctcagcaaa tacatctgag tttcctatat caactgcccc
    46381 agactgaacc tgggacaagc ctgtaccaga acctccccct tggacattga ccgtttttcc
    46441 aacatggatc gtgccaaatt catctgccgc tacttcaacc aagggttgca aggcagttga
    46501 gccaacagcc gttatggatt ctccacgatc aatccagcta gcacagccta ctaaacaagc
    46561 cgtcagccaa aaagcgataa gagacagagc aagctttttt ctttttttca ctgtttttct
    46621 cctcgaaaat aattatgaat actgtgaatt ttttaagtag ttctttatga gttgacgcat
    46681 gaattcttac caaatttctg cgcaattgat tatttatata atataggcta tattactctt
    46741 tcctaacctc cttttttcat atgtggataa aatctcttgt ctatcccttc ccccattgtc
    46801 acccattata gtcatttcgt gtctcttttt ccccttttta atgcaaggga aattactctc
    46861 cttagatgat aatccaaaag ctagaaaggt atctcaaacc tctctactct cccagactag
    46921 tttacaacta aaaggaaaag attctatttt atgagaaatc tagtttacaa gcggtaagaa
    46981 cgctaataac taaacttctt gtactctttg aaaatctctt caaagcagtg ttttgagcta
    47041 tctatggcta gcttcctagt ttgctctttg attttcattg agtagtaaaa ctacatgtaa
    47101 tggcaatcaa gatatcaaga atcatcctac taaaaaaatc catactttca ctataacata
    47161 gaataagata tttgactagc attttcattt gaatctgagg ccttttggaa aataattttt
    47221 caaaacattt ccagtaacct ttgcaaagcc caagccattg cctttaacca aaacttggta
    47281 ccaaccattt ggcagacttt ctgccagctg aacgatttct ccagccgcat acttgacaaa
    47341 cgcttcttgg ccaatttcaa ccgactgttc gacctgactc ggtttcaagg ctaaaccaag
    47401 agcgaaactg ggctcaaagc gtttcttctt aaaagtgccc agatgcagtc cattgcgagc
    47461 aatcttgagc ttccctaaat ctggcaaaag ttctggcaag agataaagct ggtctccaaa
    47521 agtctgcaag atacccggta gattgacctt caaatggttt tgggcaaatt cctgccacaa
    47581 ggcaacttgt tcacggctga ggttactctt acttgcctta aatttaggag ctggattgtt
    47641 acccttaaac tgtagatggg caacaaactg accctctccc ttaaactgat gagggtacat
    47701 ccgagccgtt tctggtaggt caataccagc taccattcca ttgatatgct ctactggcaa
    47761 caagtcaaaa tcatactctt ccagcaacca attgacaatc tcttcgtttt cctcgggtgc
    47821 ccaggtacag gtcgaataaa ccagacgacc accttcagct aacatggtca ctgcatcctc
    47881 cagaatttct ctttgcaagc tagcacattg actcggataa tctaagctcc aatagtccat
    47941 agcatcaggt tgcttacgaa acattccttc accagagcaa ggggcatcaa gaacgattaa
    48001 gtcaaaatag cctttaaaga ccttgaccaa gcggtcggca gattcattgg tcaccacgac
    48061 atttgtcgct ccaaaacgct ccatgttttc aaccaaaatc ttagcccgtt tgcttgaaat
    48121 ttcattggaa acaagtagcc cctcccctgc tagataggct gccagttgag ttgatttgcc
    48181 ccccggtgca gcagccaagt ccaagacctt cataccagga ctgggttggg ctacttgagc
    48241 caccatttga gcagcaggtt cttgcgaata aactaaacct gtagcatgct caggcgattt
    48301 ccctgaaacc ttcccatagt ggccccaagg ggtttgagta atggcatcag aaaaggaaag
    48361 ttgctcttct tttaagggat tgacccgaaa ggccgaaacc gcttcctcct caaaagaggc
    48421 aagaaaattt cttgcctcat ctcctagtat ttctttatat ttttcaacaa atccttctgg
    48481 aaattgcatt taagttcttt tcctttcgta aatataggac tgaatttcct cctgcatctc
    48541 aagaggcacc atcatgacag gctgtctggt ttgaaaatca ggagcttcac caaaaagggt
    48601 cacaacccga tagcccagac tttcccctaa aatactagct gcggcataat cccatggttg
    48661 cagataggtg agataggtca acaaatgccc tgacaaaatc ttggcaaaac taatggccgc
    48721 acttccatag acacgaacac caagaaccgc tcggctcaaa tcagccagcc cccattcatt
    48781 ggtttccagc ataccactat tccctgcaat gagaaaatct ccaagtggtt tagttttaaa
    48841 aggagctagg ggcctatcat ttagacaaac tggaaattcc ccaccaccgt ggtaacaatc
    48901 ccctttgacc acatcataaa tcagaccaaa ctgtccctga ccattttcaa aataagccat
    48961 cataacagca aaatcttcct gctgggctac aaaattattg gtaccatcaa tgggatcaat
    49021 gacccaaacc ttgccctctt gaaccgaggc tcgcagacaa ccttcttcag cacaaatctt
    49081 atcctcagga taacgggaca aaatctcacc aaccaagagt tcctgaactt ctttgtccag
    49141 tctggtcacc aaatctgttg gagaggactt ggtttcaaca cgcaagtctt cctgcatatg
    49201 gtcaagaatg tactgacctg ctttcttaac aagctcttta gcaaattcaa atttactttc
    49261 caagagaaat ctttccttcc cctttttctt tggcagcctg aactgctcgg taaagtgaat
    49321 agccactaac cgtttcaaat tctcgtccca aacgtttctc ttcgctcttg cttggcacga
    49381 ccgctttgaa tcccttatag gagtccagta actttttagc ctctactttg ccttcatagg
    49441 cagcttcaac atcattaaaa aaagaaagca ctgaagcaag ttcttcagtg ctccacgaca
    49501 aatctagtgg gtaactatac tgtttgttca ttaactaata ccagctctca ttcttgcttc
    49561 ttttagttct tgcttacgat aactacgagg gagaaaagca cgaatctcat cttcattaaa
    49621 accgatttgc atacgcttgg catcaataat aattggacga cgcaaaatac taggatactg
    49681 ctcaatcaaa tgaagcaatt ccgataccga aatactctct acatcaatat tcaatttttg
    49741 aaaaattttt gaacgagttg aaatgatgtc atcagtacca ttttcggtca aggaaaggat
    49801 gtgttgcaat tcttttcttg ttaaaggact ggtcataata ttgtgttcca caaagggaac
    49861 cttatgtttt tctaaccagg ccttagcctt acgacatgat gtacagctcg gtgatagaaa
    49921 tagtgtaatc atgcttttct cttcttatct atactttgct acttctatta tacaaaaaaa
    49981 taaagcgctt gactagagat ttttagaaaa aaagcctatt ttttcaagaa aaataggctg
    50041 tttgcgaacg attgacacaa ttggatttgg ttaattcact cttaacgatg gttttaaacg
    50101 atatatattt ttatatatgt aaattaaaaa catctttcct ttcacttcct acgacttttc
    50161 agatacagat agccaaagaa gttttcatag agggcaaaaa agaggaggaa ggcatgaaga
    50221 aagaaggtct ctggcaaaat cataataaca ggatccttgg ctggatcaaa aagccaggta
    50281 tcatctccca caaagagaat ttgatggaaa agagtaaaga attggtcaaa accaatcaaa
    50341 actcccccaa gtccaatcat cacaggtaag actactagag ccaggagact ttttcgataa
    50401 agagacaaaa agtccttttt cacaatccta ttgacaaaga catagaaact tggcagtgtc
    50461 actagagcta ctagctgaac caaatgaaag agattcttga ccactgcgaa atggtgcaga
    50521 ccagctgctg acgaacgaaa atcaggcatc tgtaagacct gactaaaagg attggtcaga
    50581 taattcatca agatatgaaa attgtattga atggtttctg gttttagata gactcgattc
    50641 gttaagttta gccactgaat ctccatagga tagaaaatcc aagccagata aatggtcaga
    50701 aggattgaga gggagaggag aaagagcata gagccccaaa aggtcaattt agttttcatc
    50761 aaaatcccac tccgcaaggc tagaaaccac atgtgtcggt gcgattggca ggccagctac
    50821 ttcttctgcc ttagtaaaac ctgtcgtcac caagagcgtt ggaatgccat tgtcaatccc
    50881 agcccagata tcagtcaaat aattgtcccc aaccatgatt aactcttcac gttccaaacc
    50941 taagtgctca accgccttgt ccataatgat ggcattgggt tttccgatat aaaccggctt
    51001 cactcgtgtc gctacttcaa gcagcataat cagtgagcca gcacctggca aaagaccgcg
    51061 ttccgtcggg atgttgaggt caggattggt tccgataaaa tgggcaccct tttgaatagc
    51121 aagagttgct gtggcaaatt tttcatagtc gacttgccaa tccagaccaa ctaccacgta
    51181 ggcagggttt tccttgtctt ccacataacc agccgccttg atggcttcct tgagtcctgc
    51241 ttctccgacg acatagacgg tcttttcaag ccccaaatca ttcatatagt cgatggttgc
    51301 taaagtcgct gtgtagacag tcgatagggg cgtatcgata ttaaaattct gagccaacat
    51361 ctccttaaca ctctctggag tgcgggttgt attgttggtt acaaagagat agggaatgtc
    51421 ccgcttttgc aattcatgaa caaaagtctc tccagcaggg attcggtctt tccccttata
    51481 aatggttccg tctaaatcaa ttaaatagcc tttatatttc atctatttct ccctaagcct
    51541 cttttatttc ttgccaagta atgattgctt gggcattgat aaccccatca cttgtaattt
    51601 catgcttgct ttccagtcca gtccgttcaa cagccgatgt aatcacccca cctggtcgaa
    51661 cttccttgac atacttgagg ttgattttct tgggaatata gtgggtcaaa aaatccgctc
    51721 ccatgacctc aaaaatccag tccaagtatt tactgttatt gacatgacca ttcatatcca
    51781 agtcgtaaaa acgaacatgg taatccttgc tgatcagctc ttccaaggac tcatacttcg
    51841 gtccacggat aagtttttta tcaaaatcag actggtaagg agccacaatc tcaggttcaa
    51901 cagcatggac ttttcgactg tcgcggtcca tgagaacaaa ggtcgccatc atatggatga
    51961 gctcctgccc cgcttcatta taaatagtaa agcaacggta gcaaaaaagt cgattgtagc
    52021 tcaaggcttc cgtttcgatg gtaatttctt ccgcaaaacg aggcaaacga accacctcaa
    52081 tatcatattc tgcgataatc cagaccagat tatagtcttc caaaatggcc ttatcactaa
    52141 ctcccagttc aatcgactgc atccctgaaa cttgcagtga cagcaaaatc acatctggaa
    52201 gtttgatatg accgttcata tcagccatat caaaaggaat tttcattttc atttgataag
    52261 ttaagcccat gatcctactc caaaataaat cgttctgcta cagtatctcc caaaaagaga
    52321 cctctctttg tcatgcgaac gtggtcaccc tcaatctgca tgaggccttg ttgaaccaaa
    52381 tctctgacaa tttctccata aagtccagca aaagactgtc caaatttttc ctcaaatcgc
    52441 gccatggaaa ccccggattt cttgcggagt cccaagaaca tttcttcttc catttgctcc
    52501 ttttgactca ggtgatcttc tgtaatacaa gcattgcctt cctcaaccgc actgagataa
    52561 tgacgaatgg gaccatgatt tttatagcgt actccattga cataaccaga tgcccctgca
    52621 ccaataccat agtattcagc attgtcccag tacatgagat tatgacgact ttcaaagccg
    52681 ggtttggaga aattagaaat ctcataatgc tcaaaacccg ctcgctccag ctctgcaatg
    52741 atgtactcaa acatctccgc ttctagttcc tccttaggca gaggcaattt cccacgtcgc
    52801 atccggttca taaagaccgt atggttttct aaaatcaaac tatacaaact catgtgggga
    52861 atatccagtt caatggcttt agccacattt tcctttactt gctccatggt ctgaccaggc
    52921 agagcataaa tcaaatcaat ggagatgttg tcaaaaccag ccagtttcag gcgatcgata
    52981 ttttcataaa tatccttctc caaatgactg cgcccaatct ttttcaacat cttatcatca
    53041 aaggtctgga cacctagcga aacacgattg acagccgaat ttttcaaaac agctatctta
    53101 tccgcatcca aatcgcctgg attggcttca atggtcaact cttccaagac agacaagtcc
    53161 aagtttttag tcaagccatt cagtaacacc tccagttgcg gagccgacag ggctgtcggt
    53221 gttccaccac cgatataaag ggttgacaac ttttcaatat cataagaacg aaactcttcc
    53281 agcagatgct ctaaatagct gtcgactggc tgatttttga tgaagacctt tgaaaaatca
    53341 caataataac aaatctgggt acaaaatggg atgtgcacat aggctgacgt tggttttttc
    53401 tgcatagtaa ttattatacc acaaagacta gattccagat aaaaatcacc atccccagat
    53461 acatagtccg tccggagatg gtgatggttt attcttctgt tatatcaatc acaatctctt
    53521 ctgagtcatc aagagcttcg gctttttctt gccattgctc cttgagatta tttaattgat
    53581 tttttgatgc ttctgtcgct tgaaaagcat aggatttagc ttgagcaagt atactgtcca
    53641 cagtgatttc acctgactca acctgttctt ttgttttcag aacaaaatct gtagcctgct
    53701 ccttaacttc tgtcagtttt tcacagactt gctccttggc atactccgga tcttctctca
    53761 aatcatctag aaaatcttga gcctgactgc aaacttgttt gcccttatca cttgttaaaa
    53821 acaaggcaag agctgcacct gaaaccgttc ctaaaaggat tgaggataat ttacccataa
    53881 ggattctcct tttttatttt ttgaaaaatt tacttgcaag acgaagagct gacagacttg
    53941 caccagtctt gagtgttttt gaaccagctg atgaagcttt cttgctcaag acacgcgcat
    54001 ggtcattgag gtctgaaaca gatagagata aatctgcaac agcactgaag agtggatcaa
    54061 tcgtagccac cttgacattg atatcatctg ccaagacatt gaccttagcc aacaactcat
    54121 tggtgtgatg caaggtcaca tccacatctg aagtcaaggt tttaatcgtc ttttctgttt
    54181 catcgatgac acgaccaagc ttttgtacag taatgatcag atagaccaaa aagacaatca
    54241 aagctagggc aacaagaata tatgcaactt ctaacattta gttttcctcc tctgtaatat
    54301 agtaaggggc cttctttcga ttttgataaa taacgatcat tataccgaga ccgataagga
    54361 caactgacag ccattgggac actcgaagtc cgaagaacat gagactatct gttcgcatac
    54421 cttcgatgac catacgaccg aaaccatacc aaatcaagta aaaggccgtg atatgacctc
    54481 gtctgagact cttccatttc cgtctaaaaa tcagaatcaa agcaaagcca agcagattcc
    54541 ataaagactc ataaaggaaa gtcggttgac ggtagctccc ctcaatatac atctggtcac
    54601 ggataaagcc aggtagataa tccagattat ccactgttgc accataagct tcttggttaa
    54661 agaaattacc ccaacgcccc aaactttgag caatcataac gctaggcgcc gcaatatcta
    54721 gaaaatccca agtattgatg agtttacggt cagcaaagat atagagcaca agagccccag
    54781 ttatcaaacc accgtaaatg gccaaaccac cattccaaat ggcaaaaatc tctcctaaat
    54841 tctgactata gtaatcaaat cggaaaataa catagtagag acgagctcct aaaatagcca
    54901 agggaaaggc tactaagata aaatctaaaa tatcgtctgg tatgatcttc tttctaggtg
    54961 cttctttcat ggtcaaataa accgcaagaa tcaagcctgt cacaatacat aaggcatacc
    55021 aacgaatggc taggggtcct agttgaatag caattggatc aagcattttg cacctcattt
    55081 cgagctatga gacttgtcag tcgttcgtcg aacaaacggg tagcatcaaa gcccatttcc
    55141 ttggcacgat aattcatggc agctgcctca atcacaacag agatattacg acctgtttta
    55201 actggaatac gaatacgagg aatggctacg ccagaaactt caagttcctc tgcattgttt
    55261 ccaagacgat caaaggtctt atgcgtatcg taattttcca aatagacagc aagctgaacc
    55321 tgtgaagaat ccttgacagc actcgcaccg tagagactca taacatcgat aataccaacc
    55381 ccacgaattt caatcaagtg tttcaaaatt tcagctggtt caccccagag agtaatctca
    55441 tccttggcaa agatatcgac acggtcatcg gctaccaaac ggtgaccacg tttgacaagc
    55501 tcaagacctg tctcgctctt accaattcca ctatctccct gaatcaagac gcccatccca
    55561 taaatatcca tcaagacacc gtgcacactg gtacgttctg ccaaacgaga atccagatag
    55621 ctagataact ctccagataa acgactggta gctgcacggc tggttaaaat agcaatctta
    55681 cattctctag cagcctttaa catctcctct ggaaccacca aaccacgggc aacaatgact
    55741 gctggtgtct caggtagaaa catttttttc aaaacttcat aacggctgtt ggaaggcatg
    55801 ctgatcagat aagaccactc cttcatcccc aaaagttgaa tccgctctgg tgtatagtag
    55861 tcaaaatagc ctgtcatttc aagaccaggt cgcgtaatat ccgctgtatt gatttccttt
    55921 tcaagcaatt ctggttcacc atagacaata tctagtctaa gcttttcaat cacttctttt
    55981 actaaaaccg acatcatttc ctccttcaaa tgaattcttc tctctattat atcaaattgt
    56041 aggaggaagt ttcagatttt tgcaggcttt ggagtattta tttaaaagaa aaaggactag
    56101 atttctctag cctttcattt caattagaat tttttacgtt tacgagctac ttctgattta
    56161 cgtttacgtt ttacagaagg tttttcatag aattcacgtt tgcgtgtttc ttgaagagta
    56221 ccagctttag taaccgcacg tttgaaacgg cgaagtgcgt cgtcaagaga ttcattctta
    56281 cgtactactg ttttagacat ttttttcact cccttcaagt tcaatatcta tttcattcta
    56341 cacgtaaaag gaataattgt caagcaaaaa tgcggtttaa ttttgatttt ttcttccatt
    56401 tatacaagag ttgaaagcgt tcaatagaac attgcttttt tatttttcga gtaagctaag
    56461 cgcttcagca tctgcgatga tggttacatc agggtgattt tggaggctac ttgcaggtag
    56521 gttctcagtc actgggccag atactgttcc ggcaatggct tctgctttcg actcaccata
    56581 agcaaaaaga ataatagact tggcatccaa aatgttttta atccccattg aaatagcttg
    56641 ggttgggacg tcttcaatct tggcaaagaa gcgagcattg gcttcgatag tagactggtc
    56701 aagttctact agatgcgttt gactgtcaaa tggagtacca ggctcattaa agccgatatg
    56761 cccattgcga ccgattccca agatttggag gtcaactgga tggtcagcca aaatttggtt
    56821 gtagcgttca acttcagctt cagcattgtc cttaacacca cgaggcaaga aactttcttt
    56881 aaatggtttt tggttgaaca agttttcttg catgaagtaa cgataagact gtggattgtc
    56941 cccatcaagg cccacatact catcaaggtt gacactggtt agatttgaaa aatcaaggtc
    57001 actctcaaca atttccttgt aaaattcaag tgggctactt cctgtcgcaa gtcctagagt
    57061 ttgagctcca ttagccaatt tttccttcaa aatctcaaaa gcaacttttc caccttgaac
    57121 ttggttttca actttaataa ctttcatctt ttcatcctcc atttctgtct atatttatta
    57181 tatggtatag accaattttt gtcaagtgaa aacgatttaa tttctaaaaa aagagcgtcc
    57241 aaacttgaaa cgtgttataa tggataggat tagaacttag aaagaatgaa cagatatatg
    57301 aatacagctg attttgattt ccacttgcca gaggaattga ttgcccaaac gccccttgaa
    57361 aaacgtgatg cctccaaact cctcatcgtc aaccgtgaga caggagaaat gcaagataaa
    57421 catttccact ctattattga tatgctggaa cctggtgatg cccttgtcat gaacgacacc
    57481 cgagttctcc ctgcccgcct ctatggtcaa aaagtggaga caggaggtca tgtggaactt
    57541 ctcctcctta agaacactag tggagacgag tgggaagttc tggctaaacc tgccaaacgc
    57601 ctcaaggtcg gtactcgtat cagctttggt gatggccgcc tcagcgctgt cgttacagaa
    57661 gaattgaccc acgggggacg cattgtccgc tttgaatacc aaggaatttt cctagaagtc
    57721 ttggaaagtc tgggagaaat gcctctgcca ccttatatcc acgaaaaatt agatgaccgt
    57781 gaacgttatc aaaccgtcta cgccaaggaa agcggctctg ctgcagcacc gactgctggt
    57841 cttcacttca ccaaagaact gctggcagaa atccaagcta agggtgttca tctagtctat
    57901 ctgactctcc atgtcggact cggaaccttt agacctgttt ctgtggataa tctggacgaa
    57961 cacgaaatgc actcagagtt ctatcaactt tctgaggaag ctgctgccac ccttcgctct
    58021 gtcaaagaaa atggtggtcg cgtcatcgct gtcggaacca cttctatccg caccttggaa
    58081 actattggtt ccaagtttga tgggcaaatc caagcagatt ctggttggac caatatcttt
    58141 atcaaacctg ggtatgagtg gaaggtcgtg gatgccttct caaccaactt ccatctgcca
    58201 aaatcaactc tggtcatgtt ggtttctgcc tttgcaggcc gtgaattagt cttagatgcc
    58261 taccaccatg ccatccaaga acactaccgc ttcttcagtt ttggtgacgc catgtttatt
    58321 tattgagaaa gaatttctct aattcttcta ataccaataa atcgctaaga tattatttca
    58381 aagaacatct acaattgaaa ctctagctag ctgtagaaga cgcctagtac attgaaatta
    58441 aaatgcttcc ccctagcttc gaaaatattg ccatagattg cgttgactct ccaaattgat
    58501 tcatctatat tttatttcag cttcctatat tttcttcgct gtttgtaaat caaaatgcaa
    58561 gacacatgag tagcaccata tttgttactc ttatctgtcc tctcaagaga ctattatgag
    58621 ttatttcaga atcattcact actttgaccc tgactctcct tagtctcaaa atcaaagact
    58681 tatactcttc aaaaatctct tcaaaccgcg tcaacgtcac cttggattat atatgtgact
    58741 gacttcgtca gttctatcta caacctcaaa gcagtacttt gagcaacctg cgactagttt
    58801 tctagtttgc tctttgattt tcattgagta ttaaacaaaa agtgaacaaa tctgaattct
    58861 aatgtacaga agactaggct tgttcacttt tttatagtcg ctataagatg accttatcta
    58921 tagcttttta tatataatta tatattcaga catactatta tcaattttgt cgcagggagg
    58981 aatctgttaa cgcacccatt caccattatc attgactcta tagccatcta tacttgtatt
    59041 gaccgctaac tcacccgatg tatttacata ataccattta ccaccaactt ggaaccattg
    59101 attgactttc atagaaccgt tgctgttgag gtagtaccat gaatcattaa cttgtaccca
    59161 acctgttgcc atggaaccat caatattata aaaataccac ataccatttt cttgtttcca
    59221 gcctgttgtt ggagcaactg ctttagctgg ttctactgct acatctgttc cttggttaga
    59281 tgtaacagat acaggatacg aaggaataga tgattgctca ggaacaacaa ctttttcagg
    59341 ttctctcgtc cctctcctta tacgtctttt taccatctct ttagtaattt gacgagaagt
    59401 agtttcttca attgttccat cacgttcatc tacagtatag attgtagtaa gagtaattta
    59461 ccaatttctc ctacttcttc tacttcttga cttttatcaa gagttgggcc atcgagatat
    59521 tctgtttcga ttggaatttc ttggacaaga acttggggct tggttccttt tttaacaact
    59581 cttgtttgag agtcttcttt ttgacttaaa gtactctcag ttacttgtcc actctttcca
    59641 tctacatcat aagttatcgt tgtaactgtt ttcccattct ttcctagagt aatctcttgc
    59701 tcctgtcctg cagaaaggtc attgtctgct tcatatttag tagcaaatgg aacaagaact
    59761 tcttcaacct tgcttttagc tggaactttg ataactgtat ccgtggcttc ttttctatca
    59821 acagtaacct gttcggtaac atgaccagtc tctggattaa catcgtaggt ccttgtcgta
    59881 gttacatagc catcctctcc atcaattgta acaggatttt cactacggtc ttttgtttca
    59941 tctttttcat aacgaattcg cgtacttgaa attttcttgg ttactacctt aggtttagtc
    60001 gctactttta caataatatc cccattgtca gcgtcatcat actctattcc ctcttcttta
    60061 tctctagtat catctctgac atattgaatc ccatcagcag catgaacaaa acttgtattc
    60121 agattcctcc taaaaataaa gttagcccgg ttaccgcaga accaaaaatc tttccgagtt
    60181 tacgtaatgc atagcgctta ttagtattag attttgccat tacatcctac ttctagtata
    60241 gcatcttttc tatcaaacgt taaacaatat actttatata taaaatagac ttagaatgat
    60301 atattgatta ttgaactaac actttaacta tatcgtaatc aatctcatat ataaaggatt
    60361 gcagacatct tatctaaata catgctaata tatttagata caaacattcc aacttgataa
    60421 ttttcactca tctttcatca ttccttatac aactatgcag tataaataga atagttttct
    60481 catcagaatg agactatttt aatattagat aatttgatag aaaaaacatg aataaaattg
    60541 gttgaattta attccctaac tcgatagagg attctatttt aaatttaaca acagctagga
    60601 ttacactata aaaagtacat taccacctgt tcggctggag aatctagtcg attagctccc
    60661 tcttagttac aagcttaaag cgatttttta actaatacta aaccagatta aagaaggaac
    60721 tagaacatct gtcttgtact aatcaatatg ctattttaaa gtttcaaata aacttggaat
    60781 gctaattatt atatttacaa taaatagttg acttcgatag aaacagaaaa tagaattcaa
    60841 cattcttccc tacttatacc ataataaata agatccgcaa gatagccttt tctctctaca
    60901 ccattaacaa tggtttgtag ataggacatt ccagcctttt ccatgacacg acctgaagct
    60961 gggttgagac tggcataacg tgctctgacc ttttgaaaac ctgcttgagt aaaacaaaag
    61021 tccaagacag ctttcaaggc ctctgtcatc ataccatgtc cccagtaagc cttgcctagc
    61081 acatagccga tttcacagct taaatcagcc tcgtctatct taacgatgct gatatctcct
    61141 atcacttgct ctgggttttc ttttagacaa atggcccatt tgtaatagtt gagattagta
    61201 taggaagcaa cccaattgcg aatcgagttt cgagtgattt cgacatcagg atggggatcc
    61261 caggtaacat aggtcagatt ctcagcggat gaagcccaat tttgaaacat ggcttctgca
    61321 tcactctcca caaatcttct taaaatcaaa cgttctgtct gtaatatttg cgtaccgata
    61381 gatttcatga tgctacctca cttccttatt tctatgctcg tagtaaaaag gctcaactca
    61441 gtaacagcta gaaaacgagt ttgtcttcta atttcttgac gcagtcgctg cctggtttga
    61501 aatgcgctct agcaagcttt ttcaaaccta gtcatcgttg caggggtaag acgatgaaat
    61561 cgaactcttc gagttaccga atctgcctca ttttcttatt tctaaactcg gggttcaaga
    61621 tcccccagac cttctctcac tttcttattt caagatgaga ggctgaaaac ctccactgga
    61681 ggtttttctt gctttttaat ttcagggcaa gaagctaaaa aggtcccccg gaccttttta
    61741 ctcccaaaag tcatcaaata cagtgatggg taagtggcgt ttgtgttggc ctttgtgcca
    61801 ccagttttca atggtcgctt gagcttctgg gctgattgtt ttgccttcta ggtagtcgtc
    61861 aatctctgcg taggtgactc caagtgcgac ttcgtcagct aggcctggtt tatcttcttc
    61921 taggtctgcc gttgggattt tttcataaag ggctggctct gcgccaagtt tctgcaagag
    61981 ctgttttcct tggcgtttat tgaggcggta aagagggaga atatccgcac cgccgtcacc
    62041 aaacttggta aagaaacctg tgatattttc tgcggcgtgg tctgttccaa tgaccgctcc
    62101 gctatggaaa ccagcaaggg catactgagc aatcatacgg caacgtgcct tgatattccc
    62161 cttgttgaag tctgaaacag gactacctgt cgcttcaact gcagctgtca tggcatcagc
    62221 tgattccttg atattcacaa ccaagctgac atctggctgg atgaaggcta gggctttttg
    62281 agcatctgct tcatcagctt gcactccgta tggcaggcgg acagcgataa atttgtagct
    62341 atcgtctccc gtttcagctc gcagttcttc catagctaat tgcgccaaac gtcctgccaa
    62401 ggttgagtct tgtcccccag aaatccctag tacaaaggtt tttaggaagg gatgtttttt
    62461 cagatatctt tttaagaaat caatagaacg acggatttct tcctgggcat caatcactgg
    62521 tttgacaccc agctcttgga taatcgtttc ttgcaaactc attcttcttc tccttcacca
    62581 agggcttcct tgcgcatctt atcaatcaag tccatcttat cttgccatac gtcacgcgcc
    62641 aaatccactg gatagtgctg cggattgagc acacgcttat actcatccca caacttgtca
    62701 aattccttac gggcataatc ctgaatgtca gtcaaactag gcaagttgta aactaatatt
    62761 ccttctttga agatatccac caagagagga acagcatcaa aattacgaac cgtcttcttg
    62821 atgtatgtat aggtcggatg gaacatcttg atttctgtca tgtcgctaat atccacacca
    62881 tcataagtga tgtagtcacc ttctgacttg cctttttcac gactggtaat gcgccacacc
    62941 tgcttcttac ctggcgtcga cactttttcc gcattattag acagcttaat cgtattgcgc
    63001 atctggccgt tttcatcttc gattgcaaca atcttgtaaa ccgccccaag agccggctgg
    63061 tcataggctg taatcagctt ggtacccaca ccccagacat caatcttggc cttttgcatc
    63121 ttgaggttaa ggatggtatt ttcatctaga tcattagaag cataaatctt agcctctgta
    63181 aatccagcct cgtccagttg ctgacggact ttcttagaaa tgtaggcaat atccccagag
    63241 tcaatccgca cacccataaa gttaatctga tcacccagct cacgcgccac ctgaatggca
    63301 gctggtacac cgatgcgaag ggtatcatag gtatccacaa gaaagacaca atttttgtgg
    63361 gtcgcagcgt aagccttgaa agcctcatag tcattgccat aaacctgtac caaggcatgg
    63421 gcatgggttc ccaaaacagg aatgtcaaag agcttacccg cacgcacgtt gctggttcca
    63481 ttggcgccac caatcaccgc tgcgcgtgtt ccccagatgg ccgcatccat ttcttgagcc
    63541 cgacgtgtcc caaactccat caagggttca tcttcgataa ccgaacgaat acgagctgcc
    63601 ttcgtcgcca ccaaggtctg gtagttgacg atgttcaaaa gagccgtttc gaccaactga
    63661 cattgggcta gaggtccttc cacctgcaca atcggttcat tagcaaaaac caaatcccct
    63721 tcttgggcag aacgaacggt caactccaac ttgaaattgc gaaggtaatc caagaacgcc
    63781 ccatgataac caagcgactc caaataggct atatcactat ctgaaaaacg caagccttca
    63841 agatagttca caattctttc caaacctgca aaaaccgcat agccgttctt aaaaggctgt
    63901 tggcggaaat acacctcaaa gaccgccttc ttattgtgaa tcccttggtc aaagtaaacc
    63961 tgcatcatgt tgatctggta caagtccgtg tgcaatgtca aactatcatc tggatacata
    64021 cttttcctac ttccttagct agaaacccat gaaaattttc aagaactttc atgtattcca
    64081 ataaattagt actattatat cacattttag ctggattgag aaaagagtaa caagctattc
    64141 tccactctcc aattcatcca tatcttgttc aaattttttc tgagcccatt cgccatagct
    64201 cttaagacca agattgccaa taaagaccca cggaaggtaa atgacataag taatgaccca
    64261 agcagacagg tatttaaaat tcaaaggatt gtgctgataa atttctatgt tgaattgata
    64321 attctgcaac atcaaaagag ccgtaatagc caaggttagg aaaaaacaac ccaaaatcgt
    64381 aaaatgaaaa cgactatagt aggtcactcc cagataacgg gcacgattga aaaagtaaaa
    64441 tgtccctatg atgataacga ttagcagcat attagaatta aaaaggcttg gtgctaatac
    64501 tgaaatgata taagatagga gcgacaaagc gatgcagata tagagacttt cagagcccgc
    64561 tttattgaac agttgttctt ctctttcgtc tagtaattga taataataaa atctattttt
    64621 catcttcttc ctcccaaaat agttggtcta gggttttccc taaacatctg caaatagact
    64681 ggcagagcga gagactggga ttgtattttc ccgcctctat caaaccaata gtctggcgtg
    64741 tcaccccgac agcctctgcc agttgacctt gtgttaaatc acgctctacc cgagctaatt
    64801 ttaattttaa atttttagcc accttcgtcc tccttatagt tttaatactc atctactctt
    64861 aaaaaatcca aaaccaacac aagctatcag ctatttatta taaccccatt aatttgcact
    64921 ccagtattat cttcagccga aaatcagtat tttaggttgt ttgaaataaa cttcctagtt
    64981 tactctttta tttttattta gtattagctt tagtaggatc ttttaaacga gtttttattg
    65041 cttatatttc ttgtttagtt tagttggttt catatcacta ttatataatg cttttggaaa
    65101 tgagcctagt ataagtcaaa aacgtgttga atagtgaaag caggagcata ccaagatgac
    65161 tgatttttta ctgtatttta ggtatgcaaa ataatactaa atgaaactaa aatgaatact
    65221 tcttgctttt cttgagagtg aaaaagtaca ataaaatgat tgtagtgatt agcacaagat
    65281 actgactaat agacatcgta tttgaagcca caaatagagg taaagaataa aaaggaagaa
    65341 gttcaattgc tttgataaac aaatcattac tagtattcat catcatcgta tttaatatat
    65401 tagggataaa gagtagtaaa gctactaaaa taccaaatac caagccactt ttcaatttgt
    65461 ataaatagaa aatgtaggat aatagaaaat aaaacaggac taacaaaatt gtattgacta
    65521 caatagctac tataaaatct aatcctaaat cacctggaat acccaattta cttactatga
    65581 ctagtaacac aatgccattc aaagcataaa taatggaaac tgagatggca tatagaaaat
    65641 tagacaagac gtaaatcatc cgattcttct gttgattata aaacaaactt accgtattgt
    65701 gggaaaaatc tctactaatg actcgattag catgtataac agccattaac ataccgagca
    65761 tagcataaaa gtttgaaata tgcttaatac caagcgatgt cccttgagtc tttagaataa
    65821 agaatgtaag caatatcggc ggtataaacg agataagcaa actgagatat attacgcctg
    65881 atgaatataa atttcttata ttttccttaa gaaaattcaa tttatttaat ttcatgatta
    65941 taaccttcct ttattttgaa cgatttaggt aaatatcttt aagcgtctct tttttagttt
    66001 caaaatcaac tactttaata gagttttcgt taaaaaattt aaaaagctca ctactttgaa
    66061 tattcccaga catagtaatt ctcagtccct cttcctgaac aatatctcca aattcttgtt
    66121 tggtaatgaa aatgtctcta tctgtagctg atgaaaaagc tatctcaaac aagaaattat
    66181 gactatcttt tcctactttt tgaaatgtca aaagcccgtt ctccaagaaa agaactctct
    66241 cacaaatttc ttcaatgtct tctaatttat gactcgatat taaaattccc acgttttcat
    66301 ttaaagctaa ttttttttag aaccgctaaa actatttgtg atgattcaat atctaaacca
    66361 ttagtcggtt catctaaaat caatatatca ggttccgtaa cgagagttag aagcaaagct
    66421 aatttttgtt ttgtacccaa agaataggtc tttacttttt tattaataga ctgagtcaaa
    66481 tctaactctt ggatcaaact tctaaatctt tcttgattgt agtcaacacc atataaattt
    66541 gacaaatatt ttaaattctc taaacctgtt ttagataaaa ataattttgg ttcttcgatt
    66601 aaatacccaa cattatcact gcttataata ttacctgaag tcggttgatt attttgaaca
    66661 agaattttca tcaacgtact cttaccaact ccatttctcc ctactagacc aacaatttca
    66721 cccttgttaa gtgcaaaatt tatatctttg agaatgattg aatgaccata atgcttactt
    66781 acatttataa cttacatttt ttattcctcc attaatattc atggtttgct ctttgattct
    66841 tattgagttt aaaaagttgc gcctcttttt aacaatatta tatcatatat ctaacttaat
    66901 gcaatatata aatgtcattt tgtaaaattt tattaacaaa aaactctcta caacaaaata
    66961 atagagagtt ttctgcttat taattttttt caaaatatct aagacatcgc ttctttgttt
    67021 aatttgatag gctttaatac ctaagctccg actttatcac ttaaaaaata aaaaaggaca
    67081 gctaatctct tgcgcatcaa gggatttcgc cattctttaa tctcgtttaa gtgttgtata
    67141 tggagctttg cataattttt taaaactaaa caactacatt aagcacgaac tgtgacgctg
    67201 gttccatctt ccttataaag attgataagc ccctctttaa gagctcgaac catgtctcca
    67261 gcttgaacaa gttgtgggac tttaatagtc aatagttcca ttggatttgg agcgcggtcg
    67321 attttattgc ctttggcatc atgcaaatct tcaatatagg tttcaaaatg acggaaacct
    67381 ggaccataaa actcaacttg gtccccttcg ttaatgacgt tccgttgacg aatggttgct
    67441 gtttgtgtcg catcatcata agaaaccact tcagcgacaa acttgtactc aggaatttta
    67501 caacgagcac caaacaactg ctcattttca gatggtgtac catagtaaaa tcctgtaacc
    67561 agttcacgtt gggcaacctt ccacatctcg tccaccaagt cttgtttgat agcttcaaac
    67621 ttttcagaac tttcaagata ggcatccaca gccgccttgt agcagttggt tactgttgat
    67681 acgtagtgaa tagacttcat acgtccttcg atttttagac tgtccacacc attttcaatc
    67741 atatctggaa tgtggtcaat catagacatg tcaacggctg acattgaaaa ttcttctgga
    67801 atctcaccct gcaaactctt acgttctttc ccaaatggca tatcgtaaag gtcgtatttc
    67861 caacggcatg actgagaaca tccaccacgg ttggcatcac gcatactcta gacggattgt
    67921 tttgacaatt ctaacctttt agactttgca taataactgt taaacagtcg aaaattaccc
    67981 cagttttaac aagtagtcaa aataccagat aaagtaaaaa ggggctagga aaaaagtctt
    68041 taaaatctta aaaacgcata gtatcaggta ttgaacaatc ttgatattat gcgttttatt
    68101 gtgggaagat ttacttcatt ttctcttgga attgagtttt ctcctacttc aaaactagat
    68161 gatttgctat ttaaaatagc gttccttatg attttggcaa cctggattaa agcgagaaaa
    68221 acaaaagagg caacttaagc tttctttata ttgcttatat gttaatagtt ttagacaaac
    68281 accacataaa ataggcttat cctgtatcaa agataaggga taaggctcaa aagggtgatt
    68341 ttctaatgaa tcatgacacc gataacaagc ataatacttt ttacaatcat agcattgtaa
    68401 agcaataata tccagcttgc tatggtaatg aatgcatctt gtttgcttat ccactaagaa
    68461 accctgtgcc tctatcattt ccttttcctt tcttaagctc gaactgtgac gctggttcca
    68521 tcttccttat aaaaattgat gagtccttct tttaatgcac gaaccatgtc tcctgattga
    68581 acgggttgtg ggactttaat agtcaatagt tccattggat ttggagcgcg gtcgatttta
    68641 tttcctttgg catcatgcaa atcttcaata taggtttcaa aatgacggaa acctggacca
    68701 taaaactcaa cttggtcccc ttcgttaatg acgtttcgtt gacgaatggt tgctgtttgt
    68761 accgcatcat cataagaaac cacttcagcg acaaacttgt actcaggaat tttacggcga
    68821 gcaccaaaca actgctcatt ttcagatggt ataccgtagt agaaacctgt tgccaattca
    68881 cgttgggcaa ccttccacat ctcgtccacc aagtcttgtt tgatagcttc aaacttttca
    68941 ggactttcaa gataggcatc cacagccgcc ttgtagcagt tggttactgt tgatacgtag
    69001 tgaatagact tcatacgtcc ttcgattttt agactgtcca caccattttc aatcatatct
    69061 ggaatgtggt caatcataga catgtcaacg gctgacattg aaaattcttc tggaatctca
    69121 ccctgcaaac tcttacgttc tttcccaaat ggcatatcgt aaaggtcgta tttccaacgg
    69181 catgactgag aacatccacc acggttggca tcacgcatac tcatgtggtt tgaaagagta
    69241 caacgtccag agtatgaaat acacatagct ccatggacaa aggcttcaat ttcaacatct
    69301 gtacgtttgc ggatctcagc taattcttcc attgaaacct cacgcgctaa aacgacacga
    69361 gtcaagccta gctctttcca gaactcaagg gtttcatagt tagtggcact ggcttgggta
    69421 gaaaggtgga tttcaaggcc tggtgcttca gtcgctgcaa tcataatcaa ggctgggtca
    69481 gatacgataa ctgctgcaat cccgatatca cgcagtttac ggaaccactc accagcacca
    69541 gcttcatttc cttcgtgcat aaccatatta gccgctacat agaccttggc accatacttg
    69601 gccgcaaact gcacgccttc ttccatctgt tcgaaagtaa agtttcccgc acggctacga
    69661 agaccatagg cctgaccacc gataaagaca gcatctgctc catactgaac agctaccttt
    69721 agcttctcta aagtccctgc aggtgataaa acctcaggac gttttaatgt ttttgtcatg
    69781 atttctccta tttgcaatat aaaagtttga catttttcct tctcatttta tagtaaataa
    69841 aggataaaat caagcctaga cggattgttt tgacaattct aatcttttag actttgcata
    69901 ataactgtta aacagtcgaa aattacccca gttttaacaa gtagtcaaaa agtctaaaaa
    69961 agtaaaaacc agtatcccaa gatactgact cgtaaaaata cataaattag tccttagatg
    70021 actactccca ctctgttgct cctataatgg aaaaggattg atacagtcta gaatatcgct
    70081 tttttattta ttattctgat ataaaactgt tagaattgat tttttgtttt atacccaaat
    70141 atgaatagag acgtagctaa taagttgaat aacatatttg gaaaaatgag aaatagcaat
    70201 attactagaa cttttagaaa caatcaatat ttaaaaagaa aaaagctcaa agaatttatt
    70261 aaaccatgtt ataatagata tagctataat tttatttata acaagaggat agaaatgacc
    70321 gaattagaaa gaaaaaatcg aaaaattagc taagaaatat tctgataact taaacatcaa
    70381 agttcaagag agagttcgtg aaatggcaaa tgataataag agccattatt tgatatacag
    70441 agttttaggt atttcatttg aagaaggaga aaatatcgat ttgtatcaaa ataaaggtcg
    70501 ttttttatac aaatatgctg gttcattttt agaagaagct gcagtactat cctttaacga
    70561 aaaatttggt acagaaaata cttaaaaagt taacattcct aattctgaaa gtacaaaacc
    70621 taagactttt gaaattgatt gtttagtcgg agaaaaacac gcatacgaaa taaaatggtg
    70681 ggatgcaact acagatggag accatataac taaagaacac actagaataa aagttattca
    70741 taacaaagga tatataccaa ttcggttaat gttctactat ccaaatagaa ctcaagctat
    70801 aaaaattcag caaactttag aaacattgta taacggtatt ggagggaaat attatggaga
    70861 ttctgcctgg gaacatttaa gagcagtgac cggtattgat ttacttagta ttctaacaga
    70921 tattgcaaat aaaaaaacag gggtaaaatc aaaatgacag tattaaaagg agataactta
    70981 gaaatattaa aaactattga atcctcaagt attgatttaa tctatatgga ccctcctttc
    71041 tttacacaga aaacccaaaa attatctaat aacaaaaata ttatgtattc attcgaagat
    71101 acgtggactt cgattgagga ttacaaagaa tttttgtctg taagattaga agaatgcaaa
    71161 agagtgctaa aaaatagtgg cagtattttc gttcattgtg ataaaattgc aaatcatcat
    71221 attagattaa ttttagataa tatctttgga gcagatatgt ttcaaagcga aattatatgg
    71281 aactataagc ggtggtctaa ttcaaaaaag ggattattga acaatcatca aaacatttac
    71341 ttttattcaa agtcaaaaga ttttaaattt aatacaattt ttacagagta ttcttctact
    71401 acaaatatcg accaaatact agtggaacga aaacgagatg gaaactctaa aactatatat
    71461 aaagttgata ataatggtaa ctatattcta gcaaaagaga aaaatggagt tcccctttca
    71521 gatgtttgga atataccatt tcttaatcca aaagctaaag aaagagtagg ttatcctaca
    71581 caaaaaccta ttctgttatt agaacaaatt ataaagattg ctactgataa aaatgatata
    71641 gttttagacc cgttctgtgg aagtggaact actttagtag cctccaagat tttgaataga
    71701 aattatatgg ggattgattt atctgaggaa gctatcaata taactcagca acgtctggaa
    71761 aatgttataa aaacaagttc aaatttattg aataaaggaa tcgaagcata tagaaccaaa
    71821 actgaggaag aggaaaacat tcttaaatta ttacaggcaa aaattgttca aagaaataaa
    71881 ggaattgatg gttttttacc taaacatttt caaaaaaaac cgatacctat aaaaattcaa
    71941 aaaaataatg aatgtctgaa tgagagtatc tctttattac agaatgctat aaactccaaa
    72001 aaacttgatt ttggagtagt tataaaaact cattcagata atttattatt tgattttgat
    72061 acgattcctg aaaatataat agtagttgac cattttgaac ttacaatcga aaaatggtta
    72121 agtaaaagtc aacagttact atagtttgca aattatttac agaaagaaca aaaaatgctc
    72181 tgaaacactg atttcaaggc attttttgtt agtttaaaat tactcccact caactgttgc
    72241 aggtggttta cttgtaatat cgtagacgat acggttaaca tgatccactt catttacgat
    72301 acgtactgag attttttgaa gtacttccca tggaattttg gcaaaatcag cagtcatacc
    72361 atcgatagaa gtgatagcac ggattgcaat cgtgtagtca tacgtacgac cgtcacccat
    72421 aacaccgact gaacgaacgc ctgtgttaac agtgaagtat tgccaaatat cgcggtcaag
    72481 tccagcttta gcgatttctt cacgaagaat agcgtctgat tcacgaacgg tttcaagttt
    72541 ctcttcagtg atttcaccca tgacacggat agcaagtcct ggtcctggga atggttggcg
    72601 ccatacgata tggtctggca taccaagctc tgtaccaaga gcacgaactt catccttgta
    72661 aagagtattg agtggttcaa tcaattcaaa ctgcatatct tctggaagac cacccacgtt
    72721 gtggtgtgac ttgatagttt gagctgtatc cgtaccagac tcgataacat ctgtatataa
    72781 agtaccttga gcaaggaatt tcacatcttt gagcttgctt gcttcgtcat cgaatacata
    72841 gacaaactcg ttaccgatga ttttacgttt ttgttcaggg tcagaaacgc cagcaagttt
    72901 gtcaaggaaa cgtttagcag cgtctgcttt gacgatattc aaaccaaact taccaccgag
    72961 catgtccata acttgatcag cttcgccttt acgaagaaga ccgtggtcta cgaagataca
    73021 gatcaattga tcgccaatcg ctttttggag aagaacccca acgacagatg agtcaacacc
    73081 acctgataga ccaagaagga cacgtttatc accgacggtt tcacgaattt ttttgatctg
    73141 catgtcaatg aaattatcca ttgaccagtc acctttagcc ttacaaatgt taagggcaaa
    73201 gttacgaagg atatcatttc cgtatacaga atgacgaact tctgggtgga attggatacc
    73261 gtaaatgtgt ttatctgggt tttcgatggc tgcgtatggg cagtcagctg atgtacctgt
    73321 acgaacaaag tcagcaggaa tctcagtaac cgcatcacca tggctcatca aaacagtctg
    73381 ttcatcaggt gttgattcaa aaagcgctga tggtgtgtga gttagggttg attgaccgta
    73441 ttcacgattt ccagcatcac ctgcaggaac aacttttcct ccaagtttat gggtcaataa
    73501 ctgcatacca taacagattc ccaaaattgg aattccgagt tcgaagattt ctgggtcaat
    73561 atcaaatgaa ccatcttcat atacagaatt tggaccacct gatagaataa ttcctacagg
    73621 attgacttca cgaacttcag cagctgaaat tttatggctt tttagttctg aaaaaacacc
    73681 aatctcacgg atacggcgtg aaatcagctg gttgtactgg ctaccatagt ccaatacgat
    73741 gattttttct acatcttgca aatcagttga aatgttgctc atctttttcc tttctcaaaa
    73801 gaaatatctt ttctcaatat tctatcacaa ataagggcga attaccaact aaacaaggcg
    73861 aagtttgact ttttctagtt tattggggta caatagagaa aagatagaaa tgaagtgaaa
    73921 aatatgctac ctgcttatat gaaaatccat gatcagataa aaaaggatat tgacgagcac
    73981 cgttgggcta ttggtgagag gcttcccagt gaaagagatt tagctgagca gtttgcggtc
    74041 agtcgcatga ccctccgcca agccgtatct ctattagtcg aagaaggcgt cttagagcgc
    74101 cgtgtaggaa gcggcacctt tgtttccagt actcgagtac aagaaaagat gcgagggaca
    74161 accagtttta ctgaaattgt caaatcccaa ggtaaagttc cctctagcca gctcatttcc
    74221 tacaaaaaaa ccattcccaa tgagcaagaa gttgccaagc taggaatttt tccaacggac
    74281 aatattatcc gaatggagcg ggtccgctat gccgaccaag ttcccctagt ttatgaagtt
    74341 gcttctattc ctgaaaaatt cattaaggac tttaaaaaag aagaaatcac cagtcatttc
    74401 ttccaaacct tgcaaaaaca tggctatcgt atcggtaaat cccaacagac catctatgct
    74461 cgccttgcta aagaaaagat tgcccactat ttggaagttg aaaaaggaca tgctattctt
    74521 ggattgaccc agatttccta cctagaagat ggtactgctt ttgaatacgt aaaaagtcaa
    74581 tatgtaggcg aacgctttga attttatctt gaaaataatt agattaccac gcaaaaactc
    74641 tctgtcacgg acaaagagtc ttttttattt ttctaagaat aaatctttca aagaaatcaa
    74701 agttacagca aacaatatca ttgccatacc aagaaaatca atgggataaa attgttcatt
    74761 cattattaag aaggcaaaga aaatcgccga tattggctca attgaagcca acaagcttga
    74821 cttgaccggt cctatcagac tggctccttt aaggaaagct gtataggcaa agacagtccc
    74881 gataaggata atgcctgcaa acgcaaggag aaaatcaaga ctagtcggga tatcggcctg
    74941 tagaacccct gtaaaaggaa gggcgaccaa acctgctatg accattccca caccaatgac
    75001 caagctgctc ccccactttt taatcaaggc tatgggtaaa atgatataca gagcataagt
    75061 caaggcagaa aagagacccc agaacaggcc agcaggtgtc atggataact ggtccaactg
    75121 cccatgtgtt gcgatcagga aggttcctcc gatggccaat atgatggaaa ctatctctcc
    75181 cagtgtcggt gccaccctat ccttgataca gctataaatt aaaattccga caggacaaac
    75241 atactgaagc accgtcgctg ttcccgcatt ggtctcctga atagcagaca gataggcgaa
    75301 ttggttgaga aaaagaccaa tcagagcaaa aataagaaga gacagcaaac tctttctatc
    75361 ctttaaaaag accagtattt tatcctttgt agtagcataa gccaagagca tgagaattcc
    75421 accagcgatt aaaagacgca agttggtcaa gaccagagcc gaaattccgt gtgccattag
    75481 gtattggcca ctcgttcctg acaaccccca agcaatacca gccacaactg ttagtaaagt
    75541 cccttttaaa ctatttgaca tgtctctcct tactcttctt tgcgaatcaa gttcatcact
    75601 tgattgcggt ctaatatcca ttgagctctc tcgtcctttt cataggtacg attcgatagg
    75661 aaaatagtgg cttcttgctt ctgacgattc cacatgataa aggtacctgt atagcccgta
    75721 tggtctagcc aatctccttc caaattccat gctaaagaac gttccttgtc atccaaagga
    75781 gaaaaatttt gatttaagtc tcttgcaaaa tcatctgcta aatagtgttc taaaaagatt
    75841 tgtaaatcct ttatagtcga aaataaacca gcactcccag catgtctacc caggagacga
    75901 gccttgggat catgcactat gcctgcctct acacctctaa ctgttggaac agcaagctca
    75961 actggcccaa ccttggtttc cgtcattccc caaggtttcc agacttgatc ctttaaaatc
    76021 acatccaaat cttgattaaa aattctttcc aaaataaagc ccaacaacaa aaaatggaca
    76081 tccgaataaa gaaaggctgg ctgacttcgt ctgttgagat gaaacatcgc ttcctttaat
    76141 tcaggggctg ttaaaagatc acgattagga ataaaaggat caaggtctgt tgcatgagtc
    76201 aagagctggc gaatagtgat gtctggataa tcactctcag gtaaaaaatc tattaccagt
    76261 ctatcaatat ctaattgacc tatttcccac aagaaggtac aaactgtgcc aaccccaaca
    76321 accttgctga cactagctag gtcataaact agtcctgcct cagtctgcaa gccatgctct
    76381 ggggcactct ggcctaaata gaactctgtc cattgattgt ccttaaaata cgcaaaagag
    76441 gctccgggat aaattcctgc ctcgatttgt tcttctattt ttttaataat cttggtccac
    76501 ttcatacttc ttcaaaccac aattcaacat tatttctatc tttaccaagg aagaattttt
    76561 cagacttagg aataaaatat tcagtagact caaacttctg gcgaagactt gctatgtcta
    76621 attcattgac caagaacttg agcatagata agtcccaggt aaccgtattg tccacagtca
    76681 aatcctgccc ctgagctgga ataaaatcaa gggatgcccc aatttcagat gattccaaga
    76741 aactttcgat atcagttggg agatgtaatt ccatagaaat ctcaaattta cttaaagaaa
    76801 ttgatgccaa atctgtttga aattcaggct tttctcctac ttctactaga cttgctctgt
    76861 catcttccgc atgaatcaaa atcaaatcat cttctggtga gaaaatttca aaagcgtagc
    76921 cattttgacc tttatataat cgatgaatcg aatctgtttt agataagatt ccttcaattt
    76981 ctaagggatt ttccaccttg acaatcaatc tagctagttt ttttcttccc tctaccttac
    77041 gagtacgcat actgggagct tcttctaaaa ccagcttttc aagacccgtt tggtcaccta
    77101 gtgacagaaa ggccgattct tctaacaggg ccttcattcc aagggtttca atataaaatg
    77161 tttcatttaa ttttctatta ttagctttta aagtaggaat aatccgtaca atctgattta
    77221 cattcataaa ttcctccgtc actttttatt ttaaaggatt ttagaatttt ttacaagata
    77281 ttatgctcaa atttaacatt atttagctat ttagtaaaga tagtctttca aggcttttga
    77341 caaagcctga taaccagcaa tactgaggtg cagtccatca gttgtatatt cttttttgag
    77401 ttggcctgct tgatctgtca aacaatcaaa tactggcaca aattccacct gcatataggc
    77461 agatgcaagc tcttgatagg cttgattcca attctgaatt ttttcattcg agcggatata
    77521 gactgcctgc tggtacttct ctccctcatt gacaggcaaa atggaaagca atttaatctc
    77581 tgtcaatgga taatcgcgag caacggattg aatgatagct tcgagattat tgagagcctc
    77641 attcacagga acatcctttc cgatatcatt tgtcccaatc agaagaaaaa ttttatctac
    77701 tgctccacca tatagatgag catcaaggtt ctctagtaac agtcctgtct gatagccacg
    77761 aattcctcga ttgacaatcg tctttgaagt cccaaatagc tcctgtagag gataatactc
    77821 gacaatggaa tccccaataa aaagaatgtt tggttctaca acagaaatgt gatttaggtg
    77881 acgatacttg gtttgaattt tttcttgttc ctttaggagc caattttcta ataactgtac
    77941 tgccacttca ttctcctttt tctaaccagt tttccaagac ttgataaact cctccttggc
    78001 tgttggctgg tgctagagca gtcgccacag ctttggcttt ctcatcagca ttttccatcg
    78061 cataggcaat tccagccatt tcaagcattt caacatcatt ttcactatca ccaaaagcca
    78121 tgattgcttg ggatttcaag tcccagcgct tgagtaattc ctccaagccc catgctttat
    78181 gaatcccagc ttggaggata tcaatgcaac catagccact ggatacagct cggacacggc
    78241 catcaaagag agtattgatt tcttccaaaa ccgaactcaa acgttcctca ccaacaacca
    78301 tgctcatctt gagcacacca ccaaagaggt cagatgttaa ttcatccaca aattgcatcc
    78361 gttggtagaa tttttcaatc atttctggag tcataaaact ttcaagatct gtaaaaatcg
    78421 taccttcctt gacaaaatca cccttcatcc ccgttacaac aaactggtcc tgacacgctc
    78481 gacccttgaa atgagccaaa gccttgttga caatggcgtc atcccatgtc tgagcctgaa
    78541 tcaattcatt gttttcaaaa atacgagcgc cattagcaac aaccagaacc actcgatcca
    78601 ccaagggact cagtagttgt ctcatgcggt gaatttcatt gcccgtcgca atgacaaaac
    78661 gaatgcccct ttgatccaac tgatctaaaa tcttttccaa tcgtgggaga tcaagctgac
    78721 ctctagcatc cagcaaggtc ccatccatat ctgtcgcaat taccttaatc atcatttact
    78781 ttcctctgga ttcaagctaa taccacttca atcccacatg ttcattcatt tctttatagg
    78841 ctgtatcaat tcgttcctta gtcgcttcat ctaactggtc acgatgactg ccacccctct
    78901 ataaaatctt ccaaaatata agtttggtaa tgatacaagg gatatccttc tggtgaaaag
    78961 gttccctttg gtgttcgatt gacccaagta ggatgagctt tagctgttcc gatagttgtt
    79021 tttccatcct tcttcttgat ggtgacatcc atgagaacac cacgttcagt ccacttagca
    79081 ttctcttcat ctcccataga ttcaatccgt tgattggaaa tgaagttccc catttaatag
    79141 acaatgagct tcttatctcc atctttttcc accgtttcag atggttcaac aacgtgagga
    79201 taccctccaa agataatatc cgctccccaa tcgatcatct tgtgataaag agctttttgt
    79261 tcttcagttg gttccaatcg atactcaaca cccatctgag gcatgataat ggtgatatct
    79321 gcttccttct ctgcccgttc aacttcagcc tttatcttat cttcgtttaa atctgaaaga
    79381 taacgattat agtcttcctg agaaatatac tgctcaattc cattgaaacc ataggaatag
    79441 gctaacaatg caaccttgat accattcact tccttaatga ccagcggagc ctgatcacgt
    79501 ggttcgtgcg tataaactcc gattggagtg attccagctt tctcaataat atcggccgtt
    79561 gaaataactc cctcaatttg cgaatccaaa atatgattat gagctaaatc cagcacatga
    79621 taacctgcct ccttaatagc atccataact tcagcaggag cattaaagag aggataaccc
    79681 gctaaataat gatccttatt aatggtttct tcaaaatcac caatagctaa atctgcttgc
    79741 ttgaaccaag gagtcacata ctcaaaattt tcatgaaagt cataggtacc gtcttctttt
    79801 ttagctgaaa agaaaagtcc atcgtggtag agcaaatccc cgtgggccat aattctggca
    79861 gttttttcct cttcctactc ctgagacttt tgcttagttc cctcttgaga aatagtatct
    79921 cgtttttgac tagtaaagag attccttgga agctttcaaa caacaagacc aagcccattg
    79981 ataaaccaac tgctagcaag agtatcgcca caaatccctt attgctccac ttgcgataac
    80041 tcctaaaaag tttaccaagc ccttcataaa acgaaaagct aaaccaccct gatttcgatt
    80101 ttgtcttctt tgtatcttcg tcctccctac tttcttatgc aagccttttc tttttattat
    80161 atcacagata agtatttctt tcacaattga attgaacttc ccatctattt tctataaatc
    80221 ctaaatgcca taatgctttc aattcttgtc attttgtgat atcatgtaga ggaaatgaac
    80281 taatccacag tggcttattc caagtatacc acttgggctt tggcagtagc taactgcact
    80341 aaacataata taaggagaga aaatgtctgc aatagaacgt attacaaaag ctgctcactt
    80401 aattgatatg aacgatatta tccgcgaggg aaatcctact ctacgcgcga ttgctgagaa
    80461 agtcactttc cccctatctg accaggaaat catcctaggc gaaaagatga tgcaattcct
    80521 taaacattcc caagatcctg tcatggctga aaaaatggga ctccgcggtg gtgttggact
    80581 ggctgctccc cagttagata tctcaaaacg cattatcgct gttttggtac ctaatattgt
    80641 tgaagaaggc gaaactccac aggaagccta cgatttggaa gccattatgt acaatccaaa
    80701 aatcgtctct cactctgttc aagatgctgc tcttggcgaa ggagaaggtt gcctgtctgt
    80761 tgaccgtaac gtgcctggct atgttgttcg ccatgcccgc gttactgttg actactttga
    80821 caaagatgga gaaaaacacc gtatcaaact caaaggctac aactccattg ttgttcagca
    80881 tgaaattgac cacattaacg gtatcatgtt ttacgatcgc atcaatgaaa aagacccatt
    80941 tgcagttaaa gatggtttac tgattcttga ataaagaaaa tcccgttgca agacggggtt
    81001 ttgtgttata atagaggcat gaaaacaaat gatattgtct atggtgtcca cgccgttacc
    81061 gaagctctcc ttgcaaatac aggaaacaaa ctctacctcc aagaagatct ccgaggtaag
    81121 aatgttgaga aagtcaagga actagctaca gaaaagaagg tgtccatttc ttggacatca
    81181 aaaaaatctc tctctgagat gactgaaggt gctgttcatc aaggttttgt tctacgagtg
    81241 tctgaatttg cctatagcga gctagattac atccttgcaa aaacacgcca agaagaaaat
    81301 ccacttctat tgattctaga tggtctaacc gatccccata atctgggttc tatcttgcga
    81361 acagccgatg cgaccaatgt ttcaggtgtc atcattccca agcaccgtac tgtcggagta
    81421 actcctgtcg ttgccaaaac agccacaggt gctattgaac acgttccaat tgcccgagtg
    81481 accaacctca gtcaaacctt agataaactt aaggatgaag gtttctggac ctttggaacg
    81541 gatatgaacg gtactccttg ccacaagtgg aatacaaaag ggaaaatcgc cctcatcatt
    81601 ggaaatgaag gaaaaggtat ctctagcaac atcaaaaaac aagtcgatga gatgattacc
    81661 attccgatga atggacatgt tcaaagcctt aatgccagtg ttgctgcggc cattctcatg
    81721 tacgaagttt tccgaaatag actataaaaa agtttccagt catctgattg gaaatttttt
    81781 tatgattaac tatgttctgt aatgaattta taggcttctt gaccagcgat agctccatct
    81841 ccaaccgctg ttgttacttg gcgaaggtct ttcaagcgaa catctccaac tgcaaagata
    81901 ccgtcgactg cagttttcat gtggttatct gtcacaatcc atcctgcctg atcttggata
    81961 ttcaattctt taacaaaatc gctaagaggg tccaaaccaa catagataaa gacaccaccg
    82021 aaggcttgtt ctgtcacttg acctgttttc acattttcaa atacgactga ttctactcgg
    82081 ttttcaccct tgatttccct tactacagaa tcccagataa agctgatttt ttcattcgca
    82141 aaggcgcgat cttgtaaaac cttttgggca cgaagttggt cacgacggtg aacaatggta
    82201 acagtcttag caaaacgagt caagaagagg gcttcttcaa cagctgaatc tccaccacca
    82261 actaccaata aatcttggtc acggaagaaa gcaccatcac acacagcaca gtaagaaaca
    82321 ccacgactgt tcagttcttc ttctccaggc actcccaaag gacggtgttt agaaccagtt
    82381 gctacgataa ctgtacgtgt ttcatatgtt tggtcatcag tcatcacttt cttaaaatca
    82441 ccatggtctt cgacattttc aacataacca taaatgtgct caacaccaag attttcaagt
    82501 ggttcaaaca tcttttcagc caattcaggt ccactaatat tagcgtatcc tgggtaattt
    82561 tcgatatcag atgtattatt catctgacca cctggcagac caccttcaat caaagctact
    82621 tttagattgc ttcgagcagc atacaaggcc gcagtcatcc ctgcaggtcc agcaccgata
    82681 ataatagtat cgtacatata gattccttct ttcttgttgt aactgtcttt attctaactc
    82741 tttcttgtca atcacgcaag gattatgcct tgaaaacaag aattaaactc ataaccgcaa
    82801 aggataatac tgggacaacc aagactccaa tcataatcat atcatagaga tgggcttggc
    82861 gagccctggc tgtcttatca actcccgaca tggctctcag accaatccaa atccctaaaa
    82921 aaatcagaac aaggatggtg gtcaagatca aactctcgaa atataaagaa aatagttgca
    82981 gtagcatgat ttctctcatt tctatctttt ttaaagagta aactcagcta gtccaactaa
    83041 ctgagttttc ctttatctat tatatcaaat ataagtccgt ttgtaactag cgaagaattc
    83101 ttttgtccgc tcttctttag gggtgtggat aatctcatcc ggagttccag actcgatgat
    83161 tttcccctta tctaagaaga gaattttatc cgcaacttgg gctacaaagg gcatgtcatg
    83221 actgaccaaa atcatggtct gacctgactt agcagcatct gcaatagact tttctacttc
    83281 accgaccaat tctgggtcaa gggctgaagt tggttcgtct aagagcaaaa catctggttt
    83341 catagcaagc gcacgcgcta gggcaacccg ttgcttctgt ccacctgata aatggcgagg
    83401 ataatggttt tcacggtccg aaagcccaac cttagccaac tcttccttgg caatcttagt
    83461 cgcttcttgg tcagataatt tcttgacaac aaccaagcct tctttcacat tatcaagtgc
    83521 tgttcggcgt tcaaacaaat taaactgttg gaaaaccata gacaacttac ggcgtagggc
    83581 aaggatttct tcttgagtaa ttttagaaaa atcaactgaa aaaccatcaa tctgaataga
    83641 gccactgtca ggtgtttcaa gataattgag actgcgaaga aaggttgatt ttccagctcc
    83701 tgaagaacca atcaaggcta caacttcccc tttttgaata tccaagtcca gatgatccaa
    83761 gacagtctgt cctgaaaagg atttgcttaa attcgaaatc ttaatcatta acgaaggtct
    83821 cctttcacat ctgtttgcac tgtatcaggt gcagaaatag ccatttttct ctcgatgaaa
    83881 cgaccgaggc tttcaattcc gatattgact acccaataaa caagggcaac ggagatgaag
    83941 cgttcaaaat agcgataatc agctccacct agaatctgag cttgggcaaa gacttccaca
    84001 acacccgcac taaaagctag agatgttccc ttggtcaaac cgatgaggga attaatcaag
    84061 gttggagtag ctaccaccgc tgcattagga ataatcactc gtcgataaac ttgcgctcgg
    84121 gtcataccca gactgcgtgc cgcctcaatc tcaccaggat taactgagag aatggctgca
    84181 cgaatggttt cactagcata agctgcctca ttaaaggcaa aggcgacaat cgcaaaagct
    84241 gcagctggaa tcgcattgat attgagacca gttccccatt gctgattgag ggctttcaaa
    84301 gccaaaggga ttccgtagta ggtcaacatg agttgcacca aaatcggtgt cccttttaag
    84361 aaactaacaa agaaggcctg caagggatat aaaatcttga cacgattgat cttcacaatg
    84421 gcaaaaagaa gcgccaaaac caagccaaaa agggcaccac caattgtcaa cataattgtt
    84481 gttggaagtt gttggacaat tctagggatt ccatcaaaga ccgaacgtag gctaaacagc
    84541 ttgccatccg gaatcaattg catcaagttt tggtaccaat ctgatgctaa aatcgttgta
    84601 acattcataa aaacatcctc ttctgataat gattcattct accatgcttc tgccgtcaat
    84661 gaaattattt gctacggtca gatacagact ttgtctacct actagtttat catactttga
    84721 aacagggaag ttatatattt tatctatcaa agagatagat aaaaactatt tcagtcccag
    84781 ttcttcataa gattttcgat aaccgatttg cttaacagtt ccattttcta ctaaaatggg
    84841 ccgttttaac aacataccgt cacttgctag caactcagcc gcttcttggt ttgacaaact
    84901 tcctacctta tcttttagcc ctaattcacg gtatttgata ccactggtgt tgaaaaattg
    84961 cttcaattca aatcctgagg tttctagcca attcaaaatg acttcttggc taggtgtttc
    85021 ttccacgata tggacggctt tatagtccac acctaattga tttaattctt gttttgcttt
    85081 tttacaagtt gaacatttgg ggtattcgat aaattctaac atgtgcttct ccttctattt
    85141 gtttatatct ttaaaatcta cgccttcatg ctccaagagc caagctttct tttccactcc
    85201 tgcagcatag cctgtcagac gcttgcctgc tcccaacaca cgatgacaag gtactaggat
    85261 agaccaagga ttgcgtccca ctgctccacc aattgcttga gcagaagcca cttgcaggtc
    85321 ttgagcaatt tgtccatagg tcactgtctg accataagga atgccctgta aatagtccca
    85381 aactctcttt tcaaaattcg ttccgattgg cgccaagagc aagttggata aatcctgagg
    85441 cttgccttta aagtaatcat ctaagcaagc aataactggg tctaaaatag gatgactaac
    85501 aacttcttct atcgtttcat ctcctagtcc cctctcaaaa tgcttctgct cctgaaccca
    85561 aattccatac aaataatggt catcagctac aagtgataga ataccaattg gtgaggagta
    85621 gaggattttt acatacttct tttgcattat ttctttaatt tttgataggc caagcgtttg
    85681 ccatctactg gcaccttacc aacttgttta aaaccaagtt tttcaaaaat atgttgcata
    85741 accttgtttt cagcatgcgt atctgagcga aaatcaagat aatcaaaacc ttcaatcaag
    85801 ccctctaaga aggtttgagc aactcctttt ccctgcacat ctgctgccac agcaatacgg
    85861 tgaaagacta gatactctga ctctccagct tgccagtttc cctcataaat agcttcatag
    85921 gcctcctctg gactcttggt cacagcagca taggctagca gttctccctc ttccaaggct
    85981 acgtaggctt gccctgagat gatatcatcg ataataacat ctgcatttgg atagccattt
    86041 tgccactggt tactaccagc atctgctaaa cattttttgg catcctctat cacctgcatg
    86101 atggcatcta cttcatttgg aaaagctaaa cgaatttcca tcttttttcc tcatttctga
    86161 ctagtttctc ccatcatagc ataatttaag tctttctaca agcagttaaa acttgacttt
    86221 gtatttttgt tattttataa tctagttatc aaaactatat aaaaaggagt tgaaaatgaa
    86281 aactaccttt tcctacccaa aatgggcaga aattccaaac attgacctct atctggacca
    86341 ggttttgctc tatgtcaatc aggtctgcgc ccctatctct cctaataaag acaagggcct
    86401 aacagcatct atggtcaaca attatgtgaa aaatggttac ctgacaaagc ctgacaaaaa
    86461 aaaataccaa cgccaacaga ttgcccgttt gattgctatc acaaccctca agtctgtatt
    86521 ttctattcaa gaaatagccc agacacttaa tactctacaa actcaagcaa gttcagacca
    86581 actctacgat gcttttgtgg actacatgaa ccaaggaatt gacccagcta accctattat
    86641 ccaaaccagc tgccaaaccg ttaaactcta tcatcaaact ctagacttaa tcgatcatac
    86701 tcaagaggag gtaatccaat gaacactagt cttaaactca gcaaacaact cagttttgga
    86761 gaggagattg ctaatagcgt gacccatgct gtgggtgcag tcatcatgct tatcttgctg
    86821 cctatttcat ccatctatag ttatgaagca cacggatttt tatcctctat cggcgtttcc
    86881 attttcgtca tcagtctctt tctcatgttc ctatcatcca ccatttatca ctctatggcc
    86941 tatggttcga cccacaaata tgttttgcga atcattgacc attctatgat ttacgttgcc
    87001 attgccggct catacacgcc cgttgtcttg accttgatga ataactggtt tggctatctg
    87061 attattgtca tccaatgggg aacgaccatc tttggtattc tctataaaat ctttgctaaa
    87121 aaggtcaatg agaaatttag ccttgctctt tacctgatta tgggctggtt ggttctggct
    87181 atcattcctg ccattatcaa tcaaacgaca cccgttttct ggagtctcat ggtaactggc
    87241 ggactctgtt atacagttgg agctggattt tatgccaaga aaaaacctta tttccacatg
    87301 atttggcatc tctttatcct agctgcgtcc gtactccaat acatcgctat tgtttattac
    87361 atgtaaaaaa gttgagaaat tcaatctcaa cttttttctt tacacatatt gataaagtac
    87421 tggtgcaagc gcacatcatc agtcaattct ggatgaaaag aacttaccaa catatttttt
    87481 tcttgggctg caacaatttg attgttcact gttgctagaa tttctacacc ctcaccaaca
    87541 ctactgataa tcggaccacg gataaaggtc attggaatct tgccaactcc cttacattct
    87601 gcttccgtgt agaaacttcc taattggcgc ccataagcat tacgctcgac caccatatcc
    87661 atagttccta gatgactctc tttctgagaa gtgatttcct tagccagcaa aattaagccc
    87721 gcacaggtcc caaacactgg taagccagat agaatggctt ctcggatggg aagtagcatg
    87781 ttctggtcac gtaagagctt gcccatggtt gtagactcac caccaggcaa aatcaaaccc
    87841 gacaagtcac tctgatcttg ctgaaaatca tctagatttc tgagttctac actctcgaca
    87901 cctaattgat ctagcacttt tgcatgttct gcaaaggccc cttgcaaggc caatattccg
    87961 attttcatct attttcctcg ttcagccatg aggatttgga tttcattttc attaatacca
    88021 accatggctt ctcctaaatc ttcagagatt tgagctagga tttgaggatt acggaagtta
    88081 gtcacagcct taacaatggc actcgctcgt ttaacaggat ctcctgactt gaaaatacct
    88141 gaaccgacaa agaccccctc tgcccctagt tgcatcatta acgcagcatc tgctggcgtt
    88201 gcaacacctc cagcagcgaa atttacaact ggcaattttc catgttcatg aacatattgg
    88261 accaattcta cagggacttg caaatccttg gcagcaacat aaagctcgtc ctcacgtaag
    88321 ttttgaatgc ggcgaatttc ctgattcatc atacgcatat gacgaacagc ttggactata
    88381 tcccctgtcc ctggttctcc tttggtacga atcatggaag caccttcagc gatacgacgc
    88441 aaggcttcac ccaaatcctt agcaccacag acaaaaggaa cttggaattc tttcttgtcc
    88501 acatggaaac ggtcatcagc tggagataga acttcactct cgtcgatata atcaatttca
    88561 atagcctcta aaatctgagc ttcaacaaaa tgcccgattc tgaccttagc cattactgga
    88621 atactaaccg cttcttggat ttccttaatc atctttgggt cgctcatgcg ggaaactcct
    88681 ccagctgcac gaatatcagc cggaattcgt tccaaggcca tcacagctgc cgcaccagca
    88741 gcttctgcga tacgagcctg ttcaggattc tgcacatcca taataacacc acccttgagc
    88801 atctgtgcca agtttttatt tagttcataa cgattttcag tcatttgttt tatcctcatc
    88861 atttgtattg gtagctacct tttcatttta agtcagaaca gaatgaagca caagataaaa
    88921 aaactataat tgtatgggga caaattagct aaaaactatc tgaccttaac ttaaggccag
    88981 atagctcatt catttttatt tttcagccgt aagggcagcc attgtgatgt agttgtatgg
    89041 tttgttgaag tgtggcaaga agaagaggtc tgtcaatgcc aatttatcaa ttgtcacatg
    89101 ctcttggata gcaagtgaga acatgtggat tcccatgcta attgcaatat catgtgaaac
    89161 catttgggca ccaagaattt cacggctatc tttgtcaaag acaatcttaa ttgctacttc
    89221 atggttgtca tgtttcatga attctggttt ttgaagatcg ttaaagcctg tttcagttgc
    89281 gttgtaacca gcagctttcg ctttttcaag agtcaaacca gttgaaacca tgtgaagacc
    89341 gtagattgag ataccatttg aaccttgaac accgattcct tccaattcat gtccacaagc
    89401 gttgtaggca ccaacgatac cagtgcgaac agcatttgaa gcaagagcga tatagcttgt
    89461 atctttacga gcattgtcat aaacagtcgc acagtcacca acagcgtaaa cgcctgggat
    89521 agatgtttct tgtttcttgt ctacaaggaa ggcaccgttg cggaagagtt cgatcttacc
    89581 atctgcaagg gctgtgtttg gacggaaacc aactgcaagg ataaccatat ccacgtcaaa
    89641 gctttctttg tcagtaatca agcgttcaac tttaccgtca ccttcgattg ctttaacagt
    89701 ttgacctaga gccaagcgga tgttgtgatc ttccaagttc ttcgccatca tttgtgtgaa
    89761 gtctttgtca tagtaaccgt tcaagacagt atcaacgata tcaacaagga caacttcttt
    89821 tccaagacgt tcaaaggctt cagcaagttc aacaccgatg taaccaccac caacaacggc
    89881 gatacggtcg aggtgttggc tcttgtcaga aagtttattg ataacttctt cagcattttg
    89941 gtacaatttc acgaattgta cgttttcaag agttgcttta aattcgcggt ttcctttaac
    90001 aatttcaaca ccttcgattg gtggcaagat tggtgtagaa cctgtagcga aaatcaattt
    90061 ttcgtatgat tctttgtgct cttttccttc aacttccgct gtaactactt tgttatcata
    90121 gtcgattgaa agaacaggtg agttcatgta aactttagca cctttagctt ccaatttttc
    90181 tttatcagaa tagaacaagc cttcagcacc gtcaatttgt tcaccaatcc aaagagccat
    90241 tccacatcct aggaaagaga tgttagagtt ttggtcaaat acaacaattt cgttctcatt
    90301 tccaaaatta tccaacatgg tattgataca tgctgtacca gcgtggttag caccgactac
    90361 aacgatttta ctcataaaaa tttcctgcct tcattctaaa tttaccttac tagtatacca
    90421 tttaccgtta gcgtttacaa ggggggtact attatttcag cattttttat caaaaataat
    90481 tccccattta tcctgttttc aagcctcatg aattttatga gcatatttct tgactttttc
    90541 caaattttgt ttgtgaaaat tctaacttta tggtattata ataacatgaa aatgaaatgt
    90601 aagggcttca atttagatga ttatttgata ttacaactta ttttctataa gagaaaggag
    90661 ttggtagctt gactcttcgt tcacattctg aacggctaat ggggactact atcactattt
    90721 cattagtgga tgagcaagcc gatatctttc tccaaaaatc ctttgacttg ctcaaagaac
    90781 ttgaataccg cttcaacgcc aatagtcaag aatctgagtt gatggaaatc aattatcaag
    90841 caggaatagc ccccgtcacg gttcatccag acctgtttga gctgatttca cttgggttag
    90901 agcatagcct agcgctctct agccacctca atatcagcat tggtccctta attcaaacct
    90961 ggcgtatcgg tttttcagat gccaaggtcg cccagcctca agaaattgaa tcggtgctgc
    91021 ctctaatcaa tcctcatggt atcgagttag attcttctac ttctactgtg tttttaaaac
    91081 agaaaggaat gaagatcgat ctaggttgtt tagccaaagg atacagtgcg gataaggttg
    91141 cccaatttct taggaaagag ggggtgactt ctgccttgat caatctggga gggaatatcc
    91201 tgaccattgg aaaaaatcag gcaagagggg ataacccatg gcaaatcggg attcaagacc
    91261 cagccaatcc taggggaaat catttaatga ccatccctgt tgtcaataaa tctgtcgtga
    91321 cttcaggcat ttatgaacgt cacctgaccg tcgatggaca agattaccat cacatttttg
    91381 acagtcaaac aggatatcct gttgaaacgg aactagcgag tctaacaatc atctctgata
    91441 aatcagtcga tggcgaaatc tggacgactc gactctttgg agaaagacct gcttctatcc
    91501 tctggcaagt cgaaaatttg gagggcatcg aagtcatcct catcgataaa gaaggccacc
    91561 taagctgttc ttcaggaatt cctactctat agagacaact gtttcaatgg aattttaaaa
    91621 ttgtattatg taaaaagaga aaggaaatct catgttaaaa cttattgcta ttgttggaac
    91681 aaattcaaaa cgttctacaa accgtcaatt gcttcaatac atgcaaaaac actttgctga
    91741 caaagctgaa attgagcttg ttgaaatcaa ggccattcct gtcttcaaca aaccagctga
    91801 caagcaagta cctgctgaaa tattggaaat tgctgctaaa atcgaagaga cagatggcgt
    91861 tattatcggt actcctgagt atgatcactc tattccagct gttttgatga gcgctcttgc
    91921 ttggttgtct tatggtattt acccactttt gaacaaacca atcatgatta caggtgcttc
    91981 ttacggtacg cttggttcat ctcgtgccca attgcaactt cgtcaaatct tgaatgctcc
    92041 tgaaatcaag gcaaatgttc ttccagatga attcttgctc tcacactctc ttcaagcatt
    92101 taacccaagt ggcgacttgg ttgaccttga tgttatcaag aaattggatg ccatctttga
    92161 tgacttccgt atctttgtaa aaatcacaga aaaattacgt aatgcacaag aattacttcg
    92221 caaagatgct gaagactttg actgggaaaa tttgtaagat aggagaccaa aaagaatgaa
    92281 atttgttgga cttgttggat caaactacga tcaatcatat aaccgtaagc tcttggaatt
    92341 tatccgtcgc tacttcaaac tcaaatttga attagaagtt cttgaaattg acgaagttcc
    92401 aatgtttaac caagatgaaa aatgggatga aagtttccaa ttacgttatt tatataacaa
    92461 aattactcgt gcagatggtg ttatcattgc tactcctgag cataaccaca ctatctcagc
    92521 ttcactcaaa tctgtacttg aatggctttc atacgaagtt catccatttg aaaacaagcc
    92581 tgttatgatt gtgggtgcat catactatga ccaaggaaca tcacgtgctc aagttcacct
    92641 tcgtaaaatc cttgatgctc caggtgttaa tgcctacacg cttccaggta acgaattcct
    92701 tcttggtaaa gctaaggaag cttttgataa caacggaaat atcaccaacg aaggcactgt
    92761 taaattcctt gaaacttgct tagataactt tgttaaatac gtaggagtcg tttcgaaatt
    92821 gaaaaaacca aaaccaatcg aatcagaaga cttggattgt ggaaaaccaa tcgctacaac
    92881 catcacagaa gttgaccctg acgatccaga atgggtagaa aaagttgcag caatcactgg
    92941 tgctgtttct ggtgatacct atgtcaaatt ggaccacggt atcctaacag ttaaccaaat
    93001 tgatatgttc ttgaaagcta tgccatttga attgacatac gctgacgata acaaccaatt
    93061 cctctactac aacaacgctc accaagatcc agacactatg ttcgctaaac gtgtaccacc
    93121 tcaatcaggt agccgtatgt cgactgttca tggttctctt ccaccagcac gtatgaagaa
    93181 cgtagagtgg gttatcggaa cacttcgcaa cggaaaccaa gaatacgtcc gtacgatcgt
    93241 tccaggttct cctgcaggtg ttatcaacac tcacaactac caagcaatgt actatcctga
    93301 tggatcatac gctggtatca atgaaatcgt ctttaacttc caaccatggc ttgactggta
    93361 cctaaaagag actggtcaac gtttggtggg tggtagcgga ccatttgctc ctgctgccgg
    93421 aggtcatgga gacgccgatg ctacttctgg cgcttctgat tcaggggatg ctggaggcca
    93481 cggtggtgac gcagacgcta cagccggtgc aagttactaa tgatagtttt taggaaccat
    93541 tatggttcct tttttagcga aaaaagacta gcaaacacaa actgctagtc tctttgttat
    93601 cgtttcatct atctttgtta aaagaaagaa tacatattat gaatttggat catcaagact
    93661 acggccatgt aatccttttt cacgttgtac ttggcgtagt ttttctggtg taacatcgtt
    93721 tccttcttcg tccacaattt tgattccttc aatgtggtga cgaacagcgc ggcgataacc
    93781 ttcgatgtac tcctcacgta gtttggcttg ttccactttt tcttctggtg ttaagccttc
    93841 tgtttttttc tttttagcaa gctcattgat acgagcaatt tttttcggat ccatttcttc
    93901 tcctctgtaa taagataaag tccgtttatc aaattttatt tagtgttaat ttggttaaaa
    93961 caagcaaact tagctgcttt cttggttagt tgtgacaaga ttgccaaacg attttgacgg
    94021 acagcctgat cttcagccat taccatagta ttttcaaaga aagcatcaat gactgggcta
    94081 agcgcaaaga gttgtttcaa ttgctgactt gcaggtcctg ataaaacgag tgtttctact
    94141 gcttctgcca aagctttttc ttggtcattc tcaaatagtg ctgaatcaac cgtagcaacc
    94201 ccttctgcct tctcagccag gttaaaggca cgagaaagtg attcaacaga tggtttaaaa
    94261 tcttcttcct tgcttacttc tacgagagca cttgctgctt ccaacatatc tgccacaaca
    94321 aagtttgaac ctgcaagaac tgcttctttg atatcttttg gagtagagcc catcatctta
    94381 tcaacacgag ccttgataaa gtccataacc tctgctttat tttcataagt caaactgtca
    94441 aatttcaatg cataaaggct atcaatcagc tcatccatag caatgtgcca accaaaggca
    94501 tccaagatac gaaccacacc ttgagttgca cgacgaaggg cataagggtc attagaacct
    94561 gatggaatca atcctactga gaagaaactc aaaatcgtat ccaatttgtc tgcaatggct
    94621 agaactgcgc cgaccttgct ctctggaagt tctccttcag ctgatgtagg catgtagtgt
    94681 tcacgaatag cagctgccac cgctggagtt tcaccagcaa gaagggtgta tttttcaccc
    94741 ataattcctt ggagttcgtc aaattcacca accatacctg tcaacaagtc aaacttgtaa
    94801 atggctgctg cacgagcaag gtcaactgtt tcatccactg acaaaccagc tttttctgcc
    94861 aaaagtacag tgatttgacc cgtacgaatc atgtgttcac gaagggaacc aatcttctca
    94921 tggaaggtga cattgtttaa tttttcaaca agatctgaaa tcaccaattt ttggtcttca
    94981 cgccagaaga attctccgtc ttccaagcgg gctaccaaga ctttttcatt tcctttgatg
    95041 acatttttca aacgctctgc gtttccgtta cgaacagaaa tgaagtttgg caagagtttt
    95101 ccatcttgat cacgaacaac aaagtaacgc tggtgttcct tcatagaagt caccaagact
    95161 tcttctggaa cttcaaggta tttagcatca aaacttccca tgaaggcagt tgggtattca
    95221 accaaattca agacttcatt cagcaaatcc gcatcaattt cgatacgtac accatgtttt
    95281 gcctcaattt ccttgatttg gtcaacaatc atttgctcac gttcacatgg atctgcgatt
    95341 acaaactgct tacgaaggtc ttcttcatag ctcaatgctg actgaatttt ggtttctttc
    95401 cccaagaaac gatggccacg gctcacacga cttcccttga tatcaaggaa atccaagtca
    95461 aactcttgct catccaagag aacagttaaa gtgtggacag ggcggatgta ttcaaagcta
    95521 tttccagccc agtgcatgct gacagggaaa gtcaatgact tcaagacatc tacaacacca
    95581 ggaacaatgg cttcaactgc ttgaccaact tcttccttag tgacatagac atattcttca
    95641 cccttgattt cacggaattc gatatcttca acagtcaagc cttttccacg gacaaatcct
    95701 tgagctgctt tggtgaagtt tccatcacta tccaaggcaa ttttctttgc tggtcccttg
    95761 aaatcttctg tcaaatcaga ctgtttgtct gataaaccag tcacacgaac agccaaacga
    95821 cgtggtgttg agaaggtttg aatggcttca aaagacaggc ggttttcctt gaggaaggct
    95881 gccatttttt cgcctagttg tttttcactt ggtgtgacaa cataggctgg taattcttca
    95941 agaccgagtt ctactaataa gttttttgtc atgttttttc ctttacattt tcttcaatct
    96001 tttttgatat gcaccttagg tactggggac gtcgctaact aactctgtga gtctgtatgg
    96061 aaatccaatg ctaaatttat caagatttcc aacaatctca tcaaagtgga tttagctgac
    96121 tgatttttga acctaaggtt tcaaaaatcc ccacataaca gtacggcggt gcatatccct
    96181 ctagcaagtc ttcgacttgc ctctaacgat tttagagtac agtattactc actattctgc
    96241 gtcttctgct aaaagtttag ctcttgtttc ttcatccaaa agtgggtagc ctaggcgttt
    96301 gcgttctgcg acaaaggttt tggctacgac acgggccaag ttacggatac gagcgatata
    96361 gcctgcacgc tctgttacag atacggcacc acgcgcgtca agcagattaa aggtatgtga
    96421 acatttgaga acatagtcat aggcagggtg taccaagcct tcttctaatg cacgaccagc
    96481 ttctttttca aacttatcaa agttttcaag caacatttct tggtccgaaa tttcaaatga
    96541 atattttgag tgctcatact caggctggat aaagatttct ccgtatttta caccatcagc
    96601 ccactcgata tcatagacag agtctacttc ttgaatgtaa gaagccaagc gctccaaacc
    96661 ataggtaact tccgcagtca cagggctagt tgccaatcca ccgacttgtt ggaaataagt
    96721 gaactgagtg atttccattc cgtcaagcca aacttcccaa ccaagaccag ctgaaccagt
    96781 tgatgggttt tcccagttgt cctcaacaaa acgaatatcg tgctccaaag gattgattcc
    96841 caatttttcc aaagactcaa ggtaaagttc ttggatattt gatggagaag gcttcatgac
    96901 cacctggaat tggtggtgtt ggtagagacg gttagggttt tccccataac gaccgtcagc
    96961 aggacgacgt gatggctcta cataagctgc attccatggc tcaggtccga tagcacgaag
    97021 gaaagtgtaa ggactcattg ttcccgcacc tttttcatta tcataagcct gcataagcat
    97081 acaaccttgg tcattccaaa attgttgcaa agtcaaaata atttcttgaa atgttaattt
    97141 cttagacatt gaatactcct taataaaaaa taattacttg cgacacgagt ctgcctcgtc
    97201 gatcatacga ggcaagacga gttagtactg cgtctagctc agcaccctag tgctgagcgt
    97261 ggagcagtcc gactgtaagg aggtttctgc cactgacgca gtgaaatgtc aatttcttag
    97321 acattgttta ctcctttagt ttttatattt ctttttcaat taatttctgc tgaacaaacc
    97381 aatctaacaa gggaaaagtt ttttctgtat ttgcccataa atgataagaa tctaagaccg
    97441 cttgtacact acctaaattt tctaccaact tatctactgt caaaaagctg cgccagtatt
    97501 cataaaaaat acttgcatag ttcttatcat aagtcgaaga accaaaatca ttcaatgaat
    97561 gccaaccata cttcttctga aaaagttcta cgagagattg attacaaatt ttttccgctt
    97621 gaaattcctc ttctgtcaag aaatacttgc gactaatata ttcaaccatc ccctcttcga
    97681 accagatata agagtcataa ccatcaaaat catctaaaaa atgctccgac caatgagcta
    97741 actcatgtcc tacaatctgt aagaggaaat tttcagataa agaatgatag tgactttcta
    97801 ttgcttgagt ttgctgagaa cactcgtagt ccatcaattg atacaaatac aactctttcc
    97861 aaacagctaa atcaggcgcc ataaccattc gtctattatt tgtataggct ggaacagcgc
    97921 tttccctaat aatctgtgta gcagcattaa aatctgacca aataacggct tgcggtaaat
    97981 cacagactgc aagttcattc tttaaaaaag attgataatc tttcaacttt tcagtatttc
    98041 ttactacaaa atcacgaaat gtagctagtt gactatcgtc ttttacaaga taaaggttgt
    98101 ccacggctct cctttctttc acacaataga ctgaataagc aaaagaaccg cgtccgacaa
    98161 tcctaggttg atttaaccta ggggcgtcag aaacgcggtt ccaccctaat ttattacttc
    98221 attgtttttg aaaatactac agaaagcgcc agctcattat tttgccctac ttggctccca
    98281 ctatcccaag ctcgcttgaa gaacgccata agactttctt tcctgctgac tattatatca
    98341 aaaattagaa taatgtacaa ttctttttat gattttctag aaatccacat catcaactcg
    98401 tggagcaccc gattgaacag caatcgtttt taaggtttct ctctcctcat gactcagttc
    98461 aattccaaag caatcaagat tagcttgaat acgagaggtt gtgacagatt ttggaagtgg
    98521 taaaaatcct tctgccaagc tccaggccaa ggctatctga gcaatcgatt ttccgtgatt
    98581 tgctgcgatt tcttgcactt gcttgctatc aaatagttct ccctgaccaa aaggccccca
    98641 agcttccaat aaaattccct tttcacgaca gtaagctacg acttgatctt gatacacacc
    98701 tggcgccaag cgaacttgat tgaccgccgg aagaattttt gctgtttcaa gcaaggcatc
    98761 caaatgatgg ggaagaaaat tactaacacc gatagcacgg attttccctt cttgatagag
    98821 gtcttccatc gctctccaaa cttctgcatt tcggattttc cattggtcat tttctctgag
    98881 cggttttgga tttggccaat gaatcaaata cagatccaaa taatccaagc ccagtttctc
    98941 taaagactct tcaaaagcct gacgagcttg ctcataggtt tgttggctat tccacagctt
    99001 ggtagttacg aacaattcct ctcgtggaac tccgctatct ttgattgctt gaccaacact
    99061 ttcttcattc tgataaatcg ccgccgtatc aatatgacga taaccagcct tcaaggcttc
    99121 taacactgca cgataggctt cttctccatc cttagcctta aaagttccaa atcccaatac
    99181 tggaatttct actccattat ttaattgata ggtatccata tgcttctcct tctattttat
    99241 actctcttca aaccacgtca acgtcgcctt gccgtaggta ttgttactga cttcgtcagt
    99301 tctatccaca acctcaaaac actgttttga gcaacctgca gctagtttcc tagtttgctc
    99361 tttgattttc attgagtatt attcatcaat tatagcataa aacatttttt aagtagtact
    99421 atcttttgta aaaaataagt ctatcacata tctgacagac ctattttttc ttgcttattc
    99481 atcacgacta taatacagct catgagcttt taggcgagta ttgagcatct ctggtatggt
    99541 cacaaaggta taaccttgat ttttcaaata ctcaatgacc cttggcaagg cattgactgt
    99601 cggactgtga atatcatgca tcaaaacgat agagccgtta gctacttgat gctgaatttc
    99661 tgtcaaaata gatgcttcat ttttactctt ccagtccaga ctatccacat cccacatgat
    99721 aaagctcaaa tccaagctat tgcgaatatc atctgtaata gcaccataag gtggacgcat
    99781 gagtttagaa ctagaaccca gcactttagt tagcacatcc tcagtatcag taatctgctt
    99841 tttagcttca tcaagagaga gttgcgagag aatcggatgg ctccaactat ggtttccaac
    99901 aacatgacct tcagatttta tcctcttcac caagtcctca ttcccagaaa catttttccc
    99961 aagcacaaag aaagtcgctt taatatcata tttagctagg gtctctaata cctgcggggt
   100021 cgttgctgga tttggaccat catcaaaggt tagagcgaca actttttgat gtttcttatc
   100081 aaagtaagat tggtacaagg ccgcatcttt ttcgagtaag tacgaagatt ggataacatc
   100141 aaagaaagca gatactggca aggctatctc ttctaaattt tcaaccacag gacttggata
   100201 aaggataatc tgactatcct tgtaatcaaa attccatgca gacaagtctt ggtcagagaa
   100261 gttttttaca atctgctcac tctggtcttg ctctattttt ttatcctcta tgaaggaggt
   100321 caactctttt atcagctgtt ccttagcctt actagcatct gaaaacagtt ggtcaagtgt
   100381 aaaaggttgc ccatcttctg ttaagtgaac ctttcctaga ctggtctttt cagtctcttc
   100441 aatcttaaaa gcaactaaat catagatttg tttggtcaca ttacgattaa cgactccctt
   100501 taaacctgac tcttcttgct ctgtatagta gaaaacaaga ttgtccttac tttctagctt
   100561 gtccttaaca tcttgattta tcagctccct aacagaggaa atcactttct ccccttggag
   100621 aggataatag gcaatcactt cggcttgccc ctgacgaaaa tgctccttct gatttccctc
   100681 actcaattga tcatctttct cttttttgag cgattcaatc ttttgctcaa aacttttttg
   100741 ctggtagatc ttaaaagcaa taaatccgcc taataggcaa atagaaattg ctaaaatacc
   100801 aatcaaagcc aataatacat gtctcgtttt cccgtgtctg ccacgtccta gtctactttt
   100861 attcatattt atatcataac aaatttgagc aataatttca atgatacaat ttggcaatcc
   100921 acaattcctc tagcaagcca aagcatctta catcaactcc aacatccgta tctgtagaga
   100981 ttatgtagtt ttctatctat ggaatttcta gtagattgaa gctagaatag tagacctata
   101041 cttctaaaac attgttagaa atcgatttga ctgtcctgat cgatttgtcc tgttctcatt
   101101 tcattttact ataaaactat gaaaagctag gtcatctgag aagtaattac tatcgacaat
   101161 tgcgatagcg tatactagtg cgatttgttt gtagctctgg tgggtatcac cttcacgttg
   101221 gcgaattttt tctaggtttt gattaaccta actacacaga taagcccata ggcgattgat
   101281 gaaaaaattc tgatgatgaa cctgaatttc gatgataact tggattccat tatctaactc
   101341 cgccaagacg tctatactag tatagaaatc ctgcgctgag tagggcatgg aaggcaagac
   101401 gtgaatgtta cttccctcca aaatcgtcac attttttgct ggcaagtcca gcatatcgcg
   101461 gataaattga caaatcatta gttgggctga tacccggatg tctgagaatc ctccttttcc
   101521 tccttctatt atagcacatt tttaaatcta ggtttgctag attctatgct tctatctatt
   101581 tattcggaaa agaaagcttt tcttcagaag aaagctaata gcttatttga aattttctcc
   101641 tctctattgg atagtcccgt ctatctatgt tataatgaaa gaaggattta aaatcggaaa
   101701 aggagtattt atgctaaaat taggtgtcat cggaactggc gctatcagcc atcatttcat
   101761 agaagcagcc cataccagtg gagaatacca actggtcgca atctattcta gaaaactaga
   101821 aactgcagca acctttgctt ctcgctatca gaatatccaa ctattcgatc aattagaagt
   101881 cttcttcaaa tcttcttttg atttagtcta tatcgccagt ccaaactcct tacattttgc
   101941 tcaggcaaaa gctgccttgt ctgctggtaa acatgttatt cttgaaaagc cagctgtcac
   102001 tcaaccacaa gaatggtttg atttgattca aacagctgaa aaaaataact gttttatctt
   102061 tgaagcagct cgtaattatc acgagaaagc ctttactact atcaaaaact ttttagcaga
   102121 taagcaagtg ttaggagcag atttcaacta tgccaaatac tcttccaaga tgcctgactt
   102181 attggctgga caaacaccaa atgtcttttc agaccgtttt gctggtggag ccctcatgga
   102241 tttggggatt tatcccctct atgctgctgt tcgtcttttt gaaaaagcta atgacgcgac
   102301 ttaccatgct caacagcttg acaatagcat tgacctaaat ggagatggta tcctcttcta
   102361 cccagactat caagttcaca tcaaggctgg aaaaaacatc acttccaatc ttccttgcga
   102421 gatttataca acagatggaa ccttgactct caacacgatt gagcatattc gctcagctat
   102481 ttttaccgac caccaaggaa atcaagtcca gcttcctatc caacaggctc ctcatacgat
   102541 gactgaggaa gtcgctgcat ttgcacacat gatccagcaa ccagatctga atctctacca
   102601 aacttggctg tatgatgcag gctctgttca tgagctacta tataccatgc gccagactgc
   102661 tggcgttaga tttgaggcag aaaaatgaaa accaaactac cgactgaatg gcaagaactg
   102721 agtgaccaac tcggtttcca agaattcacc cccattcaaa ctcaactatt tgagctcctt
   102781 cttgctggag aaaacctcct aggagtgagc caaaccggaa ctggtaagac cctagcgtat
   102841 ctcctaccaa gtcttctcag actacaaaag aaaaaagccc aacaactctt gattctagca
   102901 ccaaacacgg aacttgctgg acagattttt gatgtatgta aaacgtgggc agaagctatc
   102961 ggattgactg ctcaactctt cctttcaggt tcaagtcaga aacgacaaat tgaacgtctt
   103021 aaaaaggggc cagaaattct gattggaact cctggccgta tctttgaact cattaaactt
   103081 aaaaaaatca agatgatgaa tgtggaaacc atcatcctgg atgaatttga ccaattacta
   103141 gatgattctc agattcactt tgtagagaaa atcactcact acgcacctcg tgaccaccaa
   103201 ctggtctaca tgagtgccac gaccaagttt gaccaagaaa agattgtgcc gaatacacgc
   103261 actattgatc tctctgatca aaaattggac aatatccagc atttctacat gcaggtagac
   103321 caacgtcatc gagtggatat gctacgaaaa ctggctcatg tagaggattt ccgtggtcta
   103381 gtcttcttca atagcctgtc agaccttggg aatgccgagg aaaaactaca gtatcgtgat
   103441 atattggctg tttccctcgc tagtgatgtt aatgttaaat ttagaaaaat catcttagaa
   103501 aagtttaaag ataaccaact aaccctgctt cttgcaactg accttttggc tcgtggaatt
   103561 gatatcgata gcctagaatg tgtcgtaaac tttgatattc ctagagatag cgaaacctac
   103621 acacaccgtg ctggccgtac tggtcgtatg ggcaaggaag gttatgttat cactctcgtc
   103681 actcatccag aagaaatcaa aaaacttaaa aagtttgcaa gtatccgaga aattgtccta
   103741 aaaaaccaag aactctatat caaataaagc cccattgctc tatacacatc cagtgtatgg
   103801 agctttttta taagcaattc aattt
//
LOCUS       DBERMM010000003        81507 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.003, whole genome shotgun sequence.
ACCESSION   DBERMM010000003 DBERMM010000000
VERSION     DBERMM010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 81507)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 81507)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..81507
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.003"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            86..658
                     /locus_tag="ACL8AS_000277"
                     /pseudo
     CDS             86..658
                     /locus_tag="ACL8AS_000277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082046.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
     gene            671..841
                     /locus_tag="ACL8AS_000278"
     CDS             671..841
                     /locus_tag="ACL8AS_000278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228211.1"
                     /translation="MKKENEYVILTTASLGVMIGIVFAIFLDFPVEYGISLGLLNGIV
                     LGSLIVYKNNKN"
     gene            complement(1347..2693)
                     /gene="gdhA"
                     /locus_tag="ACL8AS_000279"
     CDS             complement(1347..2693)
                     /gene="gdhA"
                     /locus_tag="ACL8AS_000279"
                     /EC_number="1.4.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="HGS1228212.1"
                     /translation="MTSAKEYIQSVFETVKARNGHEAEFLQAVEEFFNTLEPVFEKHP
                     EYIEENILARITEPERVVSFRVPWVDRDGKVQVNRGYRVQFNSAVGPYKGGLRFHPTV
                     NQGILKFLGFEQIFKNVLTGLPIGGGKGGSDFDPKGKTDAEVMRFCQSFMTELQKHIG
                     PSLDVPAGDIGVGGREIGYLYGQYKRLNQFDAGVLTGKPLGFGGSLIRPEATGYGLVY
                     YTEEMLKANGNSFAGKKVVISGSGNVAQYALQKATELGATVISVSDSNGYVIDENGID
                     FDLLVDVKEKRRARLTEYAAEKATATYHEGTVWTYAGNYDIALPCATQNEINGEAAKR
                     LVAQGVICVSEGANMPSDLDAIKVYKENGIFYGPAKAANAGGVAVSALEMSQNSLRLS
                     WTREEVDGRLKDIMTNIFNTAKTTSETYGLDKDYLAGANIAAFENVANAMIAQGIV"
     gene            3225..3799
                     /locus_tag="ACL8AS_000280"
                     /pseudo
     CDS             3225..3799
                     /locus_tag="ACL8AS_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            3796..4014
                     /locus_tag="ACL8AS_000281"
     CDS             3796..4014
                     /locus_tag="ACL8AS_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228213.1"
                     /translation="MSISPRFETLEQAIASKDLEKVREAFKKMNSTWTINESVVRDNS
                     TAHYGRVETAISFLPSSMETEPTDESGT"
     gene            complement(4071..4313)
                     /locus_tag="ACL8AS_000282"
     CDS             complement(4071..4313)
                     /locus_tag="ACL8AS_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019770973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="HGS1228214.1"
                     /translation="MKKDIHPEYRPVVFMDTTTGYQFLSGSTKRSNETVEFEGETYPL
                     IRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLK"
     gene            complement(4409..5344)
                     /locus_tag="ACL8AS_000283"
     CDS             complement(4409..5344)
                     /locus_tag="ACL8AS_000283"
                     /EC_number="3.1.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0004527 - exonuclease activity [Evidence
                     IEA];
                     GO_function: GO:0008441 - 3'(2'),5'-bisphosphate
                     nucleotidase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HGS1228215.1"
                     /translation="MEICQQILEKIKEYDTIIIHRHMKPDPDALGSQVGLKALLEHHF
                     PEKTIKAVGFDEPTLTWMAEMDLVEDRAYQGALVIVCDTANTARIDDKRYSQGDFLIK
                     IDHHPNDDVYGDLSWVDTSSSSASEMITLFAQTTQLALADRDAELLFAGIVGDTGRFL
                     YPSTTARTLRLAAYLREHNFDFAALTRKMDTMSYKIAKLQGYIYDHLEVDENGAARVI
                     LSQEVLKQYNVTDAETAAIVGAPGRIDRVSLWGIFVEQADGHYRVRLRSKIHPINEIA
                     KEHDGGGHPLASGANSYSLEENEIIYQKLKNLLKN"
     gene            5448..5891
                     /locus_tag="ACL8AS_000284"
     CDS             5448..5891
                     /locus_tag="ACL8AS_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HGS1228216.1"
                     /translation="MALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDAS
                     DFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAV
                     DDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELVAKVG"
     gene            6007..6273
                     /locus_tag="ACL8AS_000285"
     CDS             6007..6273
                     /locus_tag="ACL8AS_000285"
                     /EC_number="5.4.99.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate mutase"
                     /protein_id="HGS1228217.1"
                     /translation="MDLDIIRQEIDQIDDQIVKLLEERMHLVEGVVAYKKASGKPILD
                     TKREEVIFEKVGSRVEDKRYQETIVATFSDILKRSRDYQDQNIK"
     gene            6270..6644
                     /gene="crcB"
                     /locus_tag="ACL8AS_000286"
     CDS             6270..6644
                     /gene="crcB"
                     /locus_tag="ACL8AS_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HGS1228218.1"
                     /translation="MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNY
                     LGIFCLIFLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYFSLV
                     LYLLLSIGGGLLLAYFLGRKKW"
     gene            6638..6967
                     /gene="crcB"
                     /locus_tag="ACL8AS_000287"
     CDS             6638..6967
                     /gene="crcB"
                     /locus_tag="ACL8AS_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HGS1228219.1"
                     /translation="MVIVYLAIACGLGALVRYFFSRYNQASKLPLGTLIANLLGCFLI
                     GVFYNHVESKEVYAILATGFCGGLTTFSTLNDELQRLLSDKKVFYSYLTLTYIGGLVA
                     IFLGILL"
     gene            7086..7433
                     /gene="rplS"
                     /locus_tag="ACL8AS_000288"
     CDS             7086..7433
                     /gene="rplS"
                     /locus_tag="ACL8AS_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000311 - plastid large ribosomal subunit
                     [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HGS1228220.1"
                     /translation="MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFE
                     GVVIARKGAGISENYTVRKISNGVGVERIFPIHTPRVEKIEVVRYGKVRRAKLYYLRA
                     LQGKAARIKEIRR"
     gene            7476..7547
                     /locus_tag="ACL8AS_000289"
     tRNA            7476..7547
                     /locus_tag="ACL8AS_000289"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:7509..7511,aa:Arg,seq:cct)
     gene            complement(7603..8409)
                     /gene="yidA"
                     /locus_tag="ACL8AS_000290"
     CDS             complement(7603..8409)
                     /gene="yidA"
                     /locus_tag="ACL8AS_000290"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000023490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HGS1228221.1"
                     /translation="MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATG
                     RPIAGVAKLLDDLQLRDEGDYVVTFNGALVQETATGHEIISESLTYEDYLDMEFLSRK
                     LGVHMHAITKDGIYTANRNIGKYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPE
                     ILDAAIEKIPAEFYERYSINKSAPFYLELLKKNVDKGSAITHLAEKLGLTKDETMAIG
                     DEENDRAMLEVVGNPVVMENGNPEIKKIAKYITKTNDESGVAHAIRTWVL"
     gene            complement(8422..9726)
                     /locus_tag="ACL8AS_000291"
     CDS             complement(8422..9726)
                     /locus_tag="ACL8AS_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HGS1228222.1"
                     /translation="MNEKVFRDPVHNYIHVNNQIIYDLINTKEFQRLRRIKQLGTSSY
                     TFHGGEHSRFSHCLGVYEIARRITEIFEEKYPEEWNPAESLLTMIAALLHDLGHGAYS
                     HTFEHLFDTDHEAITQEIIQSPETEIHQVLLQVAPDFPEKVASVIDHTYPNKQVVQLI
                     SSQIDADRMDYLLRDSYFTGASYGEFDLTRILRVIRPIENGIAFQRNGMHAIEDYVLS
                     RYQMYMQVYFHPATRAMEVLLQNLLKRAKELYPKDKDFFTRTSPHLLPFFEKNVTLSD
                     YLALDDGVMNTYFQLWMTSPDKILADLSQRFVNRKVFKSITFSQEDQDQLASMRKLVE
                     DIGFDPDYYTAIHKNFDLPYDIYRPESENPRTQIEILQKNGELAELSSLSPIVQSLAG
                     SRHGDNRFYFPKEMLDQNSIFASITQQFLYLIENDHFTPNKN"
     gene            9798..10175
                     /locus_tag="ACL8AS_000292"
     CDS             9798..10175
                     /locus_tag="ACL8AS_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HGS1228223.1"
                     /translation="MKIRMRNTIQFDEQLEVIDQLYDVEVHEKRDYSYLLFYNEEKEK
                     VVIKFHGQELVMSRFSNPKTIMRFLKDSDSLAYILTPMGMQEFTIQTSHYQVDRQKIE
                     LDYQLQNQEGHPFASYQLEITWG"
     gene            10266..10598
                     /locus_tag="ACL8AS_000293"
     CDS             10266..10598
                     /locus_tag="ACL8AS_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014637934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HGS1228224.1"
                     /translation="MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEE
                     FGVSRQAVYDNIKRTEKILEDYEMKLHMYSDYIVRSQIFDQILERYPKDDFLQEQIEI
                     LTSIDNRE"
     gene            10610..12181
                     /gene="ffh"
                     /locus_tag="ACL8AS_000294"
     CDS             10610..12181
                     /gene="ffh"
                     /locus_tag="ACL8AS_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002902912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0048501 - signal recognition particle,
                     plasma membrane targeting [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005048 - signal sequence binding
                     [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HGS1228225.1"
                     /translation="MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADV
                     ALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPT
                     IIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
                     FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEI
                     LLVVDAMIGQEAANVAREFNAQLEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGT
                     GEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMAEKMRENTFDFNDF
                     IDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPD
                     LLNPSRRRRIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLP
                     KNMPNMGGMDMSALEGMMGQGGMPDLSALGGAGMPDMSQMFGGGLKGKIGEFAMKQSM
                     KRMANKMKKAKKKRK"
     gene            complement(12376..13659)
                     /locus_tag="ACL8AS_000295"
     CDS             complement(12376..13659)
                     /locus_tag="ACL8AS_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007554578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="solute carrier family 23 protein"
                     /protein_id="HGS1228226.1"
                     /translation="MKQESTVDLLLDVDQRPSDGKGILLSFQHVFAMFGATILVPLIL
                     GMPVSVALFASGVGTLIYMIATGFKVPVYLGSSFAFITAMSLAMKEMGGDVSAAQTGV
                     ILTGLVYVLVATSIRFVGTKWIDKLLPPIIIGPMIIVIGLGLAGSAVTNAGLVADGNW
                     KNALVAVVTFLIAAFINTKGKGFLRIIPFLFAIIGGYLFALTLGLVDFTPVLKANWFE
                     IPGFYLPFSTGGAFKEYNLYFGPEAIAILPIAIVTISEHIGDHTVLGQICGRQFLKEP
                     GLHRTLIGDGIATSVSAFLGGPANTTYGENTGVIGMTRIASVSVIRNAAFIAIALSFL
                     GKFTALISTIPNAVLGGMSILLYGVIASNGLKVLIKERVDFAQMRNLIIASAMLVLGL
                     GGAILKLGPVTLSGTALSAMTGIILNLILPYENKD"
     gene            complement(13913..14626)
                     /gene="rsmG"
                     /locus_tag="ACL8AS_000296"
     CDS             complement(13913..14626)
                     /gene="rsmG"
                     /locus_tag="ACL8AS_000296"
                     /EC_number="2.1.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005575 - cellular_component [Evidence
                     IEA];
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0031167 - rRNA methylation [Evidence IEA];
                     GO_process: GO:0046118 - 7-methylguanosine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HGS1228227.1"
                     /translation="MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAI
                     TDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGAGFPSLPMKILYPELDVTIIDS
                     LNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT
                     IPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKK
                     KETPNKYPRKAGMPNKRPL"
     gene            14720..15280
                     /locus_tag="ACL8AS_000297"
     CDS             14720..15280
                     /locus_tag="ACL8AS_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LemA family protein"
                     /protein_id="HGS1228228.1"
                     /translation="MTWIILGVLALVVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRR
                     NDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMKASDALTRQVSGIFAV
                     AESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMFG
                     FKAADFLQTPEEEKSVPKVDFSGLGD"
     gene            15282..16181
                     /gene="htpX"
                     /locus_tag="ACL8AS_000298"
     CDS             15282..16181
                     /gene="htpX"
                     /locus_tag="ACL8AS_000298"
                     /EC_number="3.4.24.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease HtpX"
                     /protein_id="HGS1228229.1"
                     /translation="MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLV
                     IALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRVFI
                     IDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
                     ALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLV
                     QLAISRQREFLADASSVELTRNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKG
                     GGFQKLFYTHPPISERIERLKHM"
     gene            complement(16330..17889)
                     /locus_tag="ACL8AS_000299"
     CDS             complement(16330..17889)
                     /locus_tag="ACL8AS_000299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1228230.1"
                     /translation="MHYEHSRKGNHMIKINHLTITQNKDLRDLVSDLSMTIQDGEKVA
                     IIGEEGNGKSTLLKILMGEALSDFTIKGNIQSDYQSLAYIPQKLPEELKKKTLHDYFF
                     LDSIDLDYSILYRLAEELHFDSNRFASDQKIGNLSGGEALKIQLIHELAKPFEILFLD
                     EPSNDLDLETVDWLKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLV
                     EHLDYDSYSEQRKANFAKQSQQAANNQRAYDKTMEKHRRVKQSVETALRATKDSTAGR
                     LLAKKMKTVLSQEKRYEKAAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLEKENLS
                     IDDRVLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKLQRLLNDKREISLGFMPQDYHK
                     KLQLDLSPIAYLSKTGEKEELQKIQSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDL
                     VLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVSHDRRFLKEVCSIIYRMTE
                     HGLKLVNLEDL"
     gene            complement(18128..18444)
                     /locus_tag="ACL8AS_000300"
                     /pseudo
     CDS             complement(18128..18444)
                     /locus_tag="ACL8AS_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389556.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
     gene            18614..19156
                     /locus_tag="ACL8AS_000301"
     CDS             18614..19156
                     /locus_tag="ACL8AS_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HGS1228231.1"
                     /translation="MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVG
                     KVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVESYPVTEVFMEGATNQLDQEVLDDD
                     LVLPIENGELDLAESVSDNILLNIPIKVLTAEEEAGQGFVSGNDWQIMTEEEYQAQQA
                     VKKEENSPFAGLQGLFDGDE"
     gene            19156..19785
                     /gene="nth"
                     /locus_tag="ACL8AS_000302"
     CDS             19156..19785
                     /gene="nth"
                     /locus_tag="ACL8AS_000302"
                     /EC_number="4.2.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0140078 - class I DNA-(apurinic or
                     apyrimidinic site) endonuclease activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HGS1228232.1"
                     /translation="MVLSKKRARKVLEEIISLFPDAKPSLDFTNHFELLVAVMLSAQT
                     TDAAVNKATPGLFVAFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDF
                     DGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPL
                     EVEKRVMDILPPEQWLAAHQAMIYFGRAICHPKNPECDQYPQLYDFSNL"
     gene            19996..20517
                     /gene="pyrR"
                     /locus_tag="ACL8AS_000303"
     CDS             19996..20517
                     /gene="pyrR"
                     /locus_tag="ACL8AS_000303"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HGS1228233.1"
                     /translation="MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVF
                     IAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYT
                     GRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTE
                     LDDQDRVLITEEA"
     gene            20536..21459
                     /locus_tag="ACL8AS_000304"
     CDS             20536..21459
                     /locus_tag="ACL8AS_000304"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0016597 - amino acid binding [Evidence
                     IEA];
                     GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase catalytic
                     subunit"
                     /protein_id="HGS1228234.1"
                     /translation="MSENQQALNHVVSMEDLTVDQVMKLIKRGIEFKNGAQLPYEDHP
                     IVSNLFFEDSTRTHKSFEVAEIKLGLERLDFDVKTSSVNKGETLYDTILTLSALGVDV
                     CVIRHPEVDYYRELIASPTITTSIINGGDGSGQHPSQSLLDLMTIYEEFGHFEDLKVA
                     IAGDLDHSRVAKSNMQILKRLGAELFFAGPEEWRSQEFADYGKFVTIDEIIDQVDVMM
                     FLRVQHERHDSGAVFSKEDYHAQHGLTQERYDRLKETAILMHPAPINRDVEIADHLVE
                     APKSRIVQQMTNGVFVRMAILESVLASRNAN"
     gene            21509..22588
                     /locus_tag="ACL8AS_000305"
     CDS             21509..22588
                     /locus_tag="ACL8AS_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl phosphate synthase small subunit"
                     /protein_id="HGS1228235.1"
                     /translation="MTKRILVLEDGTVFEGKAFGADIDVTGEIVFNTGMTGYQESITD
                     QSYNGQILTFTYPLVGNYGINRDDYESIIPTCKGVVVFEEARRASNWRNQMTLDEFLK
                     AKKIPGISGIDTRALTKIIRKHGTMRATLTHVGDSMDHVTDQLQATVLPTDNIKQVST
                     KTSYPAPGVGLSVVLVDFGLKHSILRELSKRNCNVTVVPYSTTAEEILHLNPDGVMLS
                     NGPGNPEDVPQALDMIRGVQGKIPIFGICMGHQLFAMANGAKTYKMKFGHRGFNHAVR
                     EIATGRVDFTSQNHGYAVSREDLPEHLIITHEEINDKSVEGVRHRYQPAFSVQYHPDA
                     APGPHDASYLFDEFIEMMEVFKQSN"
     gene            22901..26077
                     /gene="carB"
                     /locus_tag="ACL8AS_000306"
     CDS             22901..26077
                     /gene="carB"
                     /locus_tag="ACL8AS_000306"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HGS1228236.1"
                     /translation="MPKRTDIQKIMVIGSGPIIIGQAAEFDYAGTQACLSLKEEGYEV
                     VLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKERPDALLPTLGGQTGLNMAMEL
                     SKNGILDELGVELLGTRLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAIAFAA
                     TIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLSPVTQCLIERSIAGFKEIEY
                     EVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALK
                     IEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEV
                     INPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMKATGEVMAIGRNIEES
                     LLKACRSLEIGVHHNEIPELAAVSDDTLIEKVVKAQDDRLFYVSEAIRRGYTPEEIAE
                     LTKIDIFYLDKLLHIFEIEQELGAHPQDLEVLKIAKLNGFSDRKIAELWGTTDDQVRQ
                     LRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIGQ
                     GVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDL
                     EQPKGVIVQFGGQTAINLAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQP
                     PGQTATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYMRTAVKASPDH
                     PVLVDSYIVGQECEVDAISDGKNVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQE
                     TIADYTKRLAIGLHCLGMMNIQFVIKDEKVYVIEVNPRASRTVPFLSKVTNIPMAQVA
                     TKLILGQSLSELGYQNGLYPESTRVHIKAPVFSFTKLAKVDSLLGPEMKSTGEVMGSD
                     ATLEKALYKAFEASYLHLPTFGNVFFTIADDAKEEALNLARRFQNIGYGILATEGTAA
                     FFASHGLQAQPVGKIGDDDKDIPSFVRKGRIQAIINTVGTKRTADEDGEQIRRSAIEH
                     GVPLFTALDTANAMLKVLESRSFVTEAI"
     gene            complement(26353..27162)
                     /locus_tag="ACL8AS_000307"
     CDS             complement(26353..27162)
                     /locus_tag="ACL8AS_000307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HGS1228237.1"
                     /translation="MQYLEKKEIKEIQLALLDYIDETCKKHDIPYFLSYGTMLGAIRH
                     KGMIPWDDDIDISLYREDYERLLKIIEEENHHRYKVLSYDTSSWYFHNFASILDTSTV
                     IEDHVKYKRHDTSLFIDVFPIDRFTDLSIVDKSYKYVALRQLAYIKKSRAVHGDSKLK
                     DFLRLCSWYALRFVNPRYFYKKIDQLVKNAVTNTPQYEGGVGIGKEGMKEIFPVDTFK
                     ELILTEFEGRMLPVPKKYDQFLTQMYGDYMTPPSKEMQEWYSHSIKAYRKN"
     gene            complement(27164..27967)
                     /locus_tag="ACL8AS_000308"
     CDS             complement(27164..27967)
                     /locus_tag="ACL8AS_000308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HGS1228238.1"
                     /translation="MKQLTVEDAKQIELEILDYIDTLCKKHNINYIINYGTLIGAVRH
                     EGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLSLETDKNYFNNFIKITDSTTKI
                     IDTRNTKTYESGIFIDIFPMDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKD
                     WIRTAFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKT
                     IDLPFENLSLPAPEKFDTILTQFYGDYMTLPPEEKRFYSHEFHAYKLED"
     gene            complement(27977..29464)
                     /gene="tacF"
                     /locus_tag="ACL8AS_000309"
     CDS             complement(27977..29464)
                     /gene="tacF"
                     /locus_tag="ACL8AS_000309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV teichoic acid flippase TacF"
                     /protein_id="HGS1228239.1"
                     /translation="MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSV
                     DTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRTFSSLFYLCIACTILTTAVYILA
                     YPLFFTDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIF
                     LFVKNEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVF
                     ANANMLFTFLDRLFLVKTGIDVNVSYYTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGK
                     GDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGILTSLFAFRT
                     IILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVAPEYYLLTTML
                     SETSLLVFYIIFIHRKQLIHLGHIFSYTVRYSLFSLSFVGIYFLINFVYPVDMVINLP
                     FLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKKS"
     gene            29800..30507
                     /locus_tag="ACL8AS_000310"
     CDS             29800..30507
                     /locus_tag="ACL8AS_000310"
                     /EC_number="2.7.7.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050518 - 2-C-methyl-D-erythritol
                     4-phosphate cytidylyltransferase activity [Evidence IEA];
                     GO_process: GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HGS1228240.1"
                     /translation="MIYAGILAGGTGTRMGISNLPKQFLELGDRPILIHTIEKFVLEP
                     SIEKIVVGVHGDWVSHAEDLVDKYLPLYKERIIITKGGADRNTSIKKIIEAIDAYRPL
                     TPEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQFITDIPN
                     RAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIFVIKGKDVALAKGEYSNLK
                     ITTVTDLKIAKSMIEKD"
     gene            30512..31534
                     /locus_tag="ACL8AS_000311"
     CDS             30512..31534
                     /locus_tag="ACL8AS_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribitol-5-phosphate dehydrogenase"
                     /protein_id="HGS1228241.1"
                     /translation="MINQIYQLTKPKFINVKYQEEAIDQENHILIRPNYMAVCHADQR
                     YYQGKRDPKILNKKLPMAMIHESCGTVISDPTGTYEVGQKVVMIPNQSPMQSDEEFYE
                     NYMTGTHFLSSGFDGFMREFVSLPKDRVVAYDAIEDTVAAITEFVSVGMHAMNRLLTL
                     AHSKRERIAVIGDGSLAFVVANIINYTLPESEIVVIGRHWEKLELFSFAKECYITDNI
                     PEDLAFDHAFECCGGDGTGPAINDLIRYIRPQGTILMMGVSEYKVNLNTRDALEKGLI
                     LVGSSRSGRIDFENAIQMMEVKKFANRLKNILYLEEPVREIKDIHRVFATDLNTAFKT
                     VFKWEV"
     gene            31551..32420
                     /gene="licA"
                     /locus_tag="ACL8AS_000312"
     CDS             31551..32420
                     /gene="licA"
                     /locus_tag="ACL8AS_000312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline kinase LicA"
                     /protein_id="HGS1228242.1"
                     /translation="MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIV
                     KFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSI
                     KTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNVVFSLE
                     KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTS
                     QEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRA
                     IKGLASYGGSDEK"
     gene            32410..33288
                     /locus_tag="ACL8AS_000313"
     CDS             32410..33288
                     /locus_tag="ACL8AS_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HGS1228243.1"
                     /translation="MKSKNGVPFGLLSGIFWGLGLTVSAYIFSIFTDLSPFVVAAAHD
                     FLSIFILLAFLLVKEGKVRLSIFLNIRNVSVIIGALLAGPIGMQANLYAVKYIGSSLA
                     SSVSAIYPAISVLLAFFFLKHKISKNTVFGIVLIIGGIIAQTYKVEQVNSFYIGILCA
                     LVCAIAWGSESVLSSFAMESELSEIEALLIRQVTSFLSYLVIVLFSHQSFTAVANGQL
                     LGLMIVFAAFDMISYLAYYIAINRLQPAKATGLNVSYVVWTVLFAVVFLGAPLDMLTI
                     MTSLVVIAGVYIIIKE"
     gene            33300..33989
                     /locus_tag="ACL8AS_000314"
     CDS             33300..33989
                     /locus_tag="ACL8AS_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="HGS1228244.1"
                     /translation="MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEK
                     GINDIIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDAD
                     NYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFW
                     DAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDY
                     RKLEEILKNEN"
     gene            34075..34923
                     /gene="dprA"
                     /locus_tag="ACL8AS_000315"
     CDS             34075..34923
                     /gene="dprA"
                     /locus_tag="ACL8AS_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009294 - DNA-mediated transformation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-processing protein DprA"
                     /protein_id="HGS1228245.1"
                     /translation="MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADIS
                     GCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDCYPWDLSEIYDAPVLLFYKGNLD
                     LLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
                     TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRG
                     VIVAEAKMRSGSLITCERAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDV
                     LAEFEF"
     gene            35807..36850
                     /locus_tag="ACL8AS_000316"
     CDS             35807..36850
                     /locus_tag="ACL8AS_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00341 family protein"
                     /protein_id="HGS1228246.1"
                     /translation="MTNNKLYSLIEFRNKIYEELELSRSDLAILLCAMLIASIGLNMD
                     STPVIIGAMLISPLMTPILGVGLSLAIFDFKLLRKSFKILAIQILASLIASTLYFYLS
                     PISYASSEIVARTSPTIWDVLIAFVGGIAGIIGARKKETNNIVPGVAIATALMPPLCT
                     VGYAIASANLKFIIGSSYLFLINCSFIVIATYIGVRLMMVKKHYFKDNEEDSKMRRIL
                     LLVAVLLMIPSFISATTLVRETLKKESLKKFISEQFQGHNILKKTYSKKTHTLKLTIS
                     GNYLTEEELDMISSKRGDYGLSDVSVQVSQLSDSEQLSKEELVEYFFQYIKDKEAKEK
                     EKANKFYTESEEQ"
     gene            37017..39104
                     /gene="topA"
                     /locus_tag="ACL8AS_000317"
     CDS             37017..39104
                     /gene="topA"
                     /locus_tag="ACL8AS_000317"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003917 - DNA topoisomerase type I (single
                     strand cut, ATP-independent) activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HGS1228247.1"
                     /translation="MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGH
                     IRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAIS
                     WHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYS
                     ISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHAS
                     FYGVDGKKMKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAAN
                     KINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGS
                     KYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQM
                     TAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNS
                     KPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTEL
                     GEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEE
                     EMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPS
                     CHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQV
                     VCSKGDYEEEKIK"
     gene            39210..39569
                     /locus_tag="ACL8AS_000318"
     CDS             39210..39569
                     /locus_tag="ACL8AS_000318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YbaN family protein"
                     /protein_id="HGS1228248.1"
                     /translation="MRLIYLIIGFLSLALAIVGVVLPLLPTTPFLLLSIACFSRSSKR
                     FEDWLYHTKLYQTYVADFRETKSITRERKKKIIVSIYVLMGISIYFAPLLPVKIGLGA
                     LTIFITYYLFKVIPDKE"
     gene            39662..40294
                     /locus_tag="ACL8AS_000319"
     CDS             39662..40294
                     /locus_tag="ACL8AS_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005507 - copper ion binding [Evidence
                     IEA];
                     GO_process: GO:0055070 - copper ion homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HGS1228249.1"
                     /translation="MIYEFCAENVTLLEKAMQAGARRIELCDNLAVGGTTPSYGVTKA
                     AVELAANYDTTIMTMIRPRGGDFVYNDLEIAIMLEDIRLTAQAGSQGVVFGALTADKK
                     LDKPNLEKLIAASKGMEIVFHMAFDELSDEDQPEAIDWLSQAGVTRILTRAGVSGYSL
                     EKRFVHYHRILEYAKGKIEILPGGGIDLENRQTFIDQVGVTQLHGTKVVF"
     gene            40338..40994
                     /locus_tag="ACL8AS_000320"
     CDS             40338..40994
                     /locus_tag="ACL8AS_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="HGS1228250.1"
                     /translation="MFEIFKSYQFNQEKAHDYGFIENSEVWTYSCQILQGDFVMTVSI
                     TADNVNFQVFDQETGDLYPHVYMESMRGSFVGNVREACLEILYQIRKACFDVQDFICH
                     QTKRIMTQVQEKYGNQLEYLWEKSPDTAVLRHEGNQKWYAVLMKISWNKLEKGREGQV
                     EAVNLKHDQVANLLSQKGIYPAFHMSKRYWISVSLDDTLSDEEVLELIEKSWNLTSKK
                     "
     gene            41064..42107
                     /locus_tag="ACL8AS_000321"
                     /pseudo
     CDS             41064..42107
                     /locus_tag="ACL8AS_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261078.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-isopropylmalate synthase regulatory
                     domain-containing protein"
     gene            42119..43156
                     /gene="leuB"
                     /locus_tag="ACL8AS_000322"
                     /pseudo
     CDS             42119..43156
                     /gene="leuB"
                     /locus_tag="ACL8AS_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399454.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
     gene            43153..43422
                     /locus_tag="ACL8AS_000323"
     CDS             43153..43422
                     /locus_tag="ACL8AS_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HGS1228251.1"
                     /translation="MKLDEKITLVLLIWNVIIFLIYGIDKSKARRRVWRIPEKILLIL
                     AFTFGGFGAWLAGITFHHKTRKWYFKTVWFLGMVTTLVALYFIWR"
     gene            43426..43785
                     /gene="leuD"
                     /locus_tag="ACL8AS_000324"
     CDS             43426..43785
                     /gene="leuD"
                     /locus_tag="ACL8AS_000324"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA];
                     GO_function: GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HGS1228252.1"
                     /translation="MAGSSREHAAWALADYGFKVVIAGSFGDIHYNNELNNDLLPIVQ
                     PREVREKLAQLKPTDQVTVDLEQQKIISPVEEFTFEIDSEWKHKLLNSLDDIGITLQY
                     EELIAAYEKQRPAYWQD"
     gene            43895..44570
                     /locus_tag="ACL8AS_000325"
                     /pseudo
     CDS             43895..44570
                     /locus_tag="ACL8AS_000325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002276310.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003725 - double-stranded RNA binding
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0061710 - L-threonylcarbamoyladenylate
                     synthase [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="L-threonylcarbamoyladenylate synthase"
     gene            44736..46667
                     /locus_tag="ACL8AS_000326"
     CDS             44736..46667
                     /locus_tag="ACL8AS_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrB family protein"
                     /protein_id="HGS1228253.1"
                     /translation="MNKRKVSLEDFYKWYSLNKEELLNKATVGEKFNDKLKEEFLQEW
                     PLDRILTMSIDEYVIGKGQQNKSLCYALEKGKYKNLFLGISGGSASKFGIYWNKKTNK
                     YKDQANNEISELDQRFSKLKSDLYEIIKEGIRFNFENSIFDMKRSTNEFIGRSAMVTK
                     LLCIYSEGDPFFGVNINSQKEFWNHFVSQTNQGGPYLQNHKIIELVSKTYPELEPSKL
                     GTMLFEYSKLFMENKEDNSTMDSSNNFRHQLTQSLLKSPNLILRGAPGTGKTYLAKEI
                     AKELTDGNEDQIGFVQFHPSYDYTDFVEGLRPVSNGDGAIEFRLQDGIFKDFCQKAKE
                     PQLIGGQDNFDEAWDSYLEYINVAEEKEYITKTSYLSVNSRQNLSVNYDSGVPGWSLP
                     SKYVYELYKDKNYNKQEYYKSGGKTVLETLRKRFGLKDYVSPTEIDTDKKFVFIIDEI
                     NRGEISKIFGELFFSIDPGYRGEKGSVSTQYANLHETDEKFYIPENVYIIGTMNDIDR
                     SVDTFDFAMRRRFRFVEVTAEGQVGMLDKELNIHAEEAKIRLRNLNAAIENVQELNSH
                     YHIGPSYFLKLKDVDFDYELLWSDYIKPLLEDYLRGSYDEVETLETLKKAFELTNNEQ
                     KDQAVADDNEGDENDDADY"
     gene            46681..47970
                     /locus_tag="ACL8AS_000327"
     CDS             46681..47970
                     /locus_tag="ACL8AS_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001223073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HGS1228254.1"
                     /translation="MIKEKFVEEYPKLSNLLLDRTLESLSQDERIFIFPNDLTHTPDL
                     DKDQKIFETVNQKIKTGNVIGFLGYGQERLTISSRFSDESNDHFLHYLLNKVLHINLT
                     SLDVALSREERLYQLLVHLFPKYLQAAIRKGLYKEYHRFSHNDSHVKGVIDVRNHLKK
                     NLPFTGNIAYATREFTYDNPLMQLVRHTIEYIKNQKSIGQGVLDNLSTSRENVSEIVR
                     VTPSYKLADRAKIIRGNQSKPIRHAYFHEYRNLQELCLMILNQEKHGLGYQDQKIYGI
                     LFDVAWLWEEYVYTLLPKGFVHPRNKDKTDGISVFSVGKRKVYPDFYDRERKIVLDAK
                     YKKLELTEKGINREDLFQLISYSYILKAEKAGLVFPSKDKVIDNEIGNLAGYGALLKK
                     WSIQIPQKSSSYSAFCKMMENSEENFKAIIDEEVGRK"
     gene            48145..49131
                     /locus_tag="ACL8AS_000328"
     CDS             48145..49131
                     /locus_tag="ACL8AS_000328"
                     /EC_number="1.7.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902560 - GMP reductase complex [Evidence
                     IEA];
                     GO_function: GO:0003920 - GMP reductase activity [Evidence
                     IEA];
                     GO_process: GO:0006163 - purine nucleotide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GMP reductase"
                     /protein_id="HGS1228255.1"
                     /translation="MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVV
                     PANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEY
                     DFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
                     AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIA
                     KSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRIL
                     LPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH"
     gene            49195..49266
                     /locus_tag="ACL8AS_000329"
     tRNA            49195..49266
                     /locus_tag="ACL8AS_000329"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:49228..49230,aa:Arg,seq:ccg)
     gene            49449..50147
                     /gene="rnc"
                     /locus_tag="ACL8AS_000330"
     CDS             49449..50147
                     /gene="rnc"
                     /locus_tag="ACL8AS_000330"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004525 - ribonuclease III activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HGS1228256.1"
                     /translation="MKELQTVLKNHFEIEFADKKLLETAFTHTSYANEHRLLKISHNE
                     RLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKL
                     GKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
                     YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQE
                     AAKNAVEKGLDSCI"
     gene            50138..53677
                     /gene="smc"
                     /locus_tag="ACL8AS_000331"
     CDS             50138..53677
                     /gene="smc"
                     /locus_tag="ACL8AS_000331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007059 - chromosome segregation [Evidence
                     IEA];
                     GO_process: GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HGS1228257.1"
                     /translation="MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESL
                     RWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVER
                     HIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKPEERRAI
                     FEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENARKFLDL
                     EGQRKAIYLDVLVAQIKENKAELESTEEELAQVQELLMSYYQKREKLEEENQTLKKQR
                     QDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEAQARLAALEDKRNS
                     LSKEKYDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEE
                     ADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLATAKEKASQQKDELETAKVQVQK
                     LLADYQAIAKEQEEQKTSYQAQQSQLFDRLDSLKNKQARAQSLENILRNHSNFYAGVK
                     SVLQEKDRLGGIIGAVSEHLTFDVYYQTALEIALGASSQHIIVEDEESATKAIDFLKR
                     NRVGRATFLPLTTIKARTISSQNQDAIAVSPGFLGMADELVTFDTRLEAIFKNLLATT
                     AIFDTVEHAREAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIFIKPELEQLQK
                     EIAADEASLGSEEAALKTLQDQMAALTERLEAIKSQGEQARIQEQGLSLAYQQTSQQV
                     EELETLWKLQEEEIDRLSEGDWQADKEKCQESLATIASEKQNLEAEIEEIKSNKNAIQ
                     ERYQNLQEEVAQARLLKTELQGQKRYEVADIERLGKELDNLNIEQEEIQRMLQEKVDN
                     LEKVDTELLSQQAEESKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEW
                     IRKQTRAEAKKEKVSERLRHLQNQLTDQYQISYTEALEKAHELENLNLAEQEVQDLEK
                     AIRSLGPVNLEAIDQYEEVHNRLDFLNSQRDDILSAKNLLLETITEMNDEVKERFKST
                     FEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKA
                     LSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGT
                     MAAADSIYGVTMQESGVSKIVSVKLKDLESIEG"
     gene            53674..54468
                     /locus_tag="ACL8AS_000332"
     CDS             53674..54468
                     /locus_tag="ACL8AS_000332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HGS1228258.1"
                     /translation="MTIKLVATDMDGTFLDGNGRFDMDRLKSLLASYKEKGIYFAVAS
                     GRGFLSLEKLFADVRDDIIFIAENGSLVEYQGQDLYEATMSRDFYLATFEKLKTSPYV
                     DINKLLLTGKKGSYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEET
                     LEAGEAWVNEHVPGVKAMTTGFESIDIVLDYVDKGVAIVELAKKLAITMDQVMAFGDN
                     LNDLHMMQVVGHPVAPENARPEILELAKTVIGNHKERSVIAYMEGL"
     gene            54468..55286
                     /locus_tag="ACL8AS_000333"
     CDS             54468..55286
                     /locus_tag="ACL8AS_000333"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HGS1228259.1"
                     /translation="MADIKLIALDLDGTLLTTDKRLTDRTKETLKAARDRGIKVVLTT
                     GRPLKAMDFFLHELGTDGQEDEYTITFNGGLVQKNTGEILDKTVFSYDDVARLYEETE
                     KLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFAQE
                     PLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGIDQSQVMACG
                     DEANDLSMIEWAGLGVAMQNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKEN"
     gene            55290..56567
                     /gene="ftsY"
                     /locus_tag="ACL8AS_000334"
     CDS             55290..56567
                     /gene="ftsY"
                     /locus_tag="ACL8AS_000334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005047 - signal recognition particle
                     binding [Evidence IEA];
                     GO_process: GO:0006614 - SRP-dependent cotranslational
                     protein targeting to membrane [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HGS1228260.1"
                     /translation="MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVDPTFTEVEEVS
                     QEEAEVEIVEQAVFQEEEIQDTVEESLDLEPVVEVSQKEVEEFPHSEEGNTEFLETIE
                     ENNSEVLEPERPQAEETVQEKYDRSLKKTRTGFGARLNAFFANFRSVDEEFFEELEEL
                     LIMSDVGVQVASNLTEELRYEAKLENAKKPDALRRVIIEKLVELYEKDGSYDESIHFQ
                     DNLTVMLFVGVNGVGKTTSIGKLAHRYKQAGKKVMLVAADTFRAGAVAQLAEWGRRVD
                     VPVVTGPEKADPASVVFDGMERAVAEGIDILMIDTAGRLQNKDNLMAELEKIGRIIKR
                     VVPEAPHETFLALDASTGQNALVQAKEFSKITPLTGIVLTKIDGTARGGVVLAIREEL
                     NIPVKLIGFGEKIDDIGEFNSENFMKGLLEGLI"
     gene            complement(56613..58100)
                     /gene="zwf"
                     /locus_tag="ACL8AS_000335"
     CDS             complement(56613..58100)
                     /gene="zwf"
                     /locus_tag="ACL8AS_000335"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004345 - glucose-6-phosphate
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0006006 - glucose metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="HGS1228261.1"
                     /translation="MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTA
                     RRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELN
                     EKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLN
                     DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLG
                     VEERGGYYDQSGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTD
                     EELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFF
                     FRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFN
                     LAPNSLDYRTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVCASWKLIDRIEKLWA
                     ENGAPLHDYKAGSMGPQASFDLLEKFGAKWTWQPDITYRQDGRLE"
     gene            complement(58249..58989)
                     /locus_tag="ACL8AS_000336"
     CDS             complement(58249..58989)
                     /locus_tag="ACL8AS_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HGS1228262.1"
                     /translation="MAKLKIDVNDLHKHYGKNEVLKGITTKFYEGDVVCIIGPSGSGK
                     STFLRSLNLLEEVTSGHITVNGYDLTEKTTNVDHVRENIGMVFQHFNLFPHMSVLDNI
                     TFAPIEHKLMTKEEAEKLGMELLEKVGLADKANANPDSLSGGQKQRVAIARGLAMNPD
                     IMLFDEPTSALDPEMVGDVLNVMKELAEQGMTMIIVTHEMGFARQVANRVIFTADGEF
                     LEDGTPDQIFDNPQHPRLKEFLDKVLNV"
     gene            complement(58989..61154)
                     /locus_tag="ACL8AS_000337"
     CDS             complement(58989..61154)
                     /locus_tag="ACL8AS_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HGS1228263.1"
                     /translation="MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQ
                     TYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFT
                     MSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFD
                     TGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEH
                     LVTEFNQALSEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSS
                     FAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGM
                     SVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQ
                     SKYGYKIKTFADGSSMYDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETA
                     FAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQ
                     NNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPL
                     MILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQ
                     MEASRSLGISYGKTMRKIILPQATKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGK
                     IIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIR"
     gene            61327..62280
                     /locus_tag="ACL8AS_000338"
     CDS             61327..62280
                     /locus_tag="ACL8AS_000338"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HGS1228264.1"
                     /translation="MKNKRIFKDFQASKMSLNIYTSLLLAFVFVFIGEFVAFTLYGIG
                     LLALIGLARNFGEAGQNLATYLQTLHQSLTDKTSDFRLILGLLAFGFILNTVFRWTRK
                     VEKRPIRTLGFYRENFLSNLLKGFSLGLALFLLTLLGLVVLGQYRLESIHLNPYSLAF
                     VVFTIPFWILQGTAEEVVARAWLLPQLASRTNLKLAILISSLFFTLLHMGNSGLTPLS
                     LVNLFLFGVAMALYLLKTDTVWGVAGIHGAWNFAQGNLFGILVSGQPSGTSLMTFLPQ
                     GNQDWLSGGSFGIEGSIMTSLVLLLLIVYLANKLKKENERM"
     gene            62357..64345
                     /gene="uvrB"
                     /locus_tag="ACL8AS_000339"
     CDS             62357..64345
                     /gene="uvrB"
                     /locus_tag="ACL8AS_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009380 - excinuclease repair complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="HGS1228265.1"
                     /translation="MINHITDNQFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMG
                     ATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQ
                     PEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYA
                     DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFR
                     VEFFGDEIDRIREVEALTGQVLGEVDHLAIFPATHFVTNDDHMEVAVAKIQAELEEQL
                     AVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPYTLLDFF
                     PDDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVH
                     QIVYVSATPGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKN
                     ERTFITTLTKKMAEDLTDYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGIN
                     LLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADTVTQSMQ
                     RAIDETARRRKIQMAYNEEHGIVPQTIKKEIRDLIAVTKAVAKEEDKEVDINSLNKQE
                     RKELVKKLEKQMQEAVEVLDFELAAQIRDMMLEVKALD"
     gene            64355..64918
                     /locus_tag="ACL8AS_000340"
     CDS             64355..64918
                     /locus_tag="ACL8AS_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family protein"
                     /protein_id="HGS1228266.1"
                     /translation="MIYLRKLKKEDLMSLWEMAYSQLNPVWKQYDAPYYDDYQYFSNF
                     KEFELQKSESILSNSNRLGIFVDDKLVGTVSRYWVCKETRWMELGIGIYDKKFWNTGI
                     GKVAMLQWIDRTFQDYLELEHLGLTTWSGNLGMMKLAEKLRMKKEAHIPKVRYYQGKY
                     FDSIKYGILREDWEKINDGYYQINGNS"
     gene            64884..65372
                     /locus_tag="ACL8AS_000341"
     CDS             64884..65372
                     /locus_tag="ACL8AS_000341"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228267.1"
                     /translation="MTVIIKSMETPEEIEGKSLVHWQTWRESYDDLLPAEFQDTMTLE
                     RCRFFSQKYPENTLIAMDGVKVVGFISYGNFRDETIQAGEIIALYVLKDYYGKGIAQK
                     LMKAALTALNHFSEIFLWVLKDNKRAIAFYQKMGFTFDGQEKILELGKPIKEKRMVFY
                     SK"
     gene            65446..65913
                     /locus_tag="ACL8AS_000342"
     CDS             65446..65913
                     /locus_tag="ACL8AS_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HGS1228268.1"
                     /translation="MSRSQLTILTNICLIEDLETQRVVMQYRAPENNRWSGYAFPGGH
                     VENDEAFAESVIREIYEETGLTIQNPQLVGIKNWPLDTGGRYIVICYKATEFSGTLQS
                     SEEGEVSWVQKDQIPNLNLAYDMLPLMEMMEAPDKSEFFYPRRTEDDWEKKIF"
     gene            complement(65910..66425)
                     /locus_tag="ACL8AS_000343"
     CDS             complement(65910..66425)
                     /locus_tag="ACL8AS_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HGS1228269.1"
                     /translation="MTKDRKQALLQLLKEAPKALNGQSLAEHFHVTRQVIVQDIAILR
                     ADGAPILSTNRGYIYKQIDTNPYVHKLFKVKHEVEEIGQELLAIVDNGGHVQNTLIDH
                     PVYGEIETLLKLSCRRDVQHFLEQVEHSDFRPLSELTDGIHYHLVEAETQQDLHYIEE
                     ALDQLGYLVKD"
     gene            complement(66437..66964)
                     /locus_tag="ACL8AS_000344"
     CDS             complement(66437..66964)
                     /locus_tag="ACL8AS_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HGS1228270.1"
                     /translation="MNTRKKTQFMTMTALLTAIAILIPIVMPFKIVIPPASYTLGSHI
                     AIFIAMFLSPLMAVFVILASSFGFLMAGYPMVIVFRAFSHISFGALGALYLQKFPDTL
                     DKPKSSWVFNFVLAVVHALAEVLACVLFYATSGTNVENMFYVLFVLVGFGTIIHSMVD
                     YTLALAVYKVLRKRR"
     gene            complement(67247..67810)
                     /locus_tag="ACL8AS_000345"
     CDS             complement(67247..67810)
                     /locus_tag="ACL8AS_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HGS1228271.1"
                     /translation="MKKRSNIAPIAIFFATMLVIHFLSSLIFNLFPFPIKPTIVHIPV
                     IIASIIYGPRVGVTLGFLMGLLSLTVNTITILPTSYLFSPFVPNGNIYSAIIAIVPRI
                     LIGLTPYLVYKLMKNKTGLILAGALGSLTNTIFVLGGIFFLFGNVYNGNIQLLLATVI
                     STNSIAELVISAILTLAIVPRLQTLKK"
     gene            complement(67794..68345)
                     /gene="coaC"
                     /locus_tag="ACL8AS_000346"
     CDS             complement(67794..68345)
                     /gene="coaC"
                     /locus_tag="ACL8AS_000346"
                     /EC_number="4.1.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenoylcysteine decarboxylase"
                     /protein_id="HGS1228272.1"
                     /translation="MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQ
                     PLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNM
                     VTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
                     RGALADLTIILERIKETIDEKTL"
     gene            complement(68357..69046)
                     /gene="coaB"
                     /locus_tag="ACL8AS_000347"
     CDS             complement(68357..69046)
                     /gene="coaB"
                     /locus_tag="ACL8AS_000347"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="HGS1228273.1"
                     /translation="MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVC
                     LITTKRALKPEPHPNLSIREITNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGL
                     EEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
                     VDVTEDHLVDIARKSLIKNQADLIIANDLTQISAGQHRAIFVEKNQLQTVQTKEEIAE
                     LLLEKIQAYHS"
     gene            69276..70946
                     /locus_tag="ACL8AS_000348"
     CDS             69276..70946
                     /locus_tag="ACL8AS_000348"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004329 - formate-tetrahydrofolate ligase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HGS1228274.1"
                     /translation="MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDK
                     IRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVM
                     GIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
                     ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRR
                     LANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIA
                     HGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRAL
                     KMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAAL
                     KELCALIDVPVELASVWADGVEGGVELAETVVKTIAENPANYKRLYDNDLSVQEKIEK
                     IVTEIYRGSKVNFEKKAQTQIAQVVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEI
                     TIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF"
     gene            71274..72449
                     /gene="mutY"
                     /locus_tag="ACL8AS_000349"
     CDS             71274..72449
                     /gene="mutY"
                     /locus_tag="ACL8AS_000349"
                     /EC_number="3.2.2.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0019104 - DNA N-glycosylase activity
                     [Evidence IEA];
                     GO_process: GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="HGS1228275.1"
                     /translation="MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPY
                     HIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLATASEESLLKAWEGLGYYSRVRNM
                     QAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
                     LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVK
                     DFSAAYQNGTMDRYPIKSPKKKPVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFP
                     FIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSH
                     RKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD"
     gene            72505..73209
                     /gene="yycF"
                     /locus_tag="ACL8AS_000350"
     CDS             72505..73209
                     /gene="yycF"
                     /locus_tag="ACL8AS_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000722069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator YycF"
                     /protein_id="HGS1228276.1"
                     /translation="MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE
                     QPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDSEFDKVIGLELGADDYVTKP
                     FSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
                     HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPE
                     YILTRRGVGYYMRNNA"
     gene            73202..74551
                     /gene="vicK"
                     /locus_tag="ACL8AS_000351"
     CDS             73202..74551
                     /gene="vicK"
                     /locus_tag="ACL8AS_000351"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall metabolism sensor histidine kinase
                     VicK"
                     /protein_id="HGS1228277.1"
                     /translation="MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQI
                     NQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFY
                     MTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
                     LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSH
                     ELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATS
                     LLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDN
                     ILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSR
                     AQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED"
     gene            74553..75362
                     /locus_tag="ACL8AS_000352"
     CDS             74553..75362
                     /locus_tag="ACL8AS_000352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HGS1228278.1"
                     /translation="MSEIGFKYSILASGSSGNSFYLETSKKKLLVDAGLSGKKITSLL
                     AEINRKPEDLDAILITHEHSDHIHGVGVLARKYGMDLYANEKTWQAMENSKYLGKVDS
                     SQKHIFEMGKTKTFGDIDIESFGVSHDAVAPQFYRFMKDDKSFVLLTDTGYVSDRMAG
                     IVENADGYLIEANHDVEILRSGSYAWRLKQRILSDLGHLSNEDGAEAMIRTLGNRTKK
                     IYLGHLSKENNIKELAHMTMVNQLAQADLGVGVDFKVYDTSPDTATPLTEI"
     gene            75453..75695
                     /gene="relB"
                     /locus_tag="ACL8AS_000353"
     CDS             75453..75695
                     /gene="relB"
                     /locus_tag="ACL8AS_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB family
                     antitoxin"
                     /protein_id="HGS1228279.1"
                     /translation="MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYD
                     ARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE"
     gene            75697..75951
                     /locus_tag="ACL8AS_000354"
     CDS             75697..75951
                     /locus_tag="ACL8AS_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA];
                     GO_function: GO:0042803 - protein homodimerization
                     activity [Evidence IEA];
                     GO_process: GO:0030541 - plasmid partitioning [Evidence
                     IEA];
                     GO_process: GO:0051290 - protein heterotetramerization
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="HGS1228280.1"
                     /translation="MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKAL
                     VGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHRRDIY"
     gene            75998..76741
                     /locus_tag="ACL8AS_000355"
     CDS             75998..76741
                     /locus_tag="ACL8AS_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005267 - potassium channel activity
                     [Evidence IEA];
                     GO_process: GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
                     /protein_id="HGS1228281.1"
                     /translation="MNKKWLFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSII
                     DLVIWGVFVIDYSWRFFTTKRKWRFILENIFDLLAILPLNAIFTVFRLGRIFRLTKLT
                     KLLKLTRLLRIIGLTGKLERKISRFLWTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
                     DSLWWALVTVTTVGYGDIVPVSLFGKWLAVLLMLVGIGTIGVLTSALTNFFVKDNPDE
                     QIKLDKLKDELSSQRILIEKQSEKIEELH"
     gene            complement(77030..78016)
                     /locus_tag="ACL8AS_000356"
     CDS             complement(77030..78016)
                     /locus_tag="ACL8AS_000356"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019768616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004459 - L-lactate dehydrogenase activity
                     [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HGS1228282.1"
                     /translation="MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLH
                     EKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNL
                     AINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
                     ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELF
                     EGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIG
                     QPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN"
     gene            78210..80678
                     /gene="gyrA"
                     /locus_tag="ACL8AS_000357"
     CDS             78210..80678
                     /gene="gyrA"
                     /locus_tag="ACL8AS_000357"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001152996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003916 - DNA topoisomerase activity
                     [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006259 - DNA metabolic process [Evidence
                     IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HGS1228283.1"
                     /translation="MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHR
                     RILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVD
                     GHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
                     FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTG
                     ALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVR
                     LVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAI
                     QNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIR
                     IIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIAD
                     LADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQVLSLEDEDLIEESDVLITLS
                     NRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRL
                     KGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTS
                     VKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRI
                     ATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAK
                     ITEKNGLLAGLMTVQGDEDLMIITDTGVIIRTNLANISQTGRATMGVKVMRLDQDAQI
                     VTFTTVAVAEKEEVGTENETEGEA"
     gene            80678..81421
                     /gene="srtA"
                     /locus_tag="ACL8AS_000358"
     CDS             80678..81421
                     /gene="srtA"
                     /locus_tag="ACL8AS_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtA"
                     /protein_id="HGS1228284.1"
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVW
                     NTNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPE
                     LEMNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNA
                     KNGMKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIV
                     KGDLKETKDYSQTSNEILTAFNQPYKQFY"
BASE COUNT        24888 a        14559 c        17819 g        24241 t
ORIGIN      
        1 aaacgcttcg gattacgaat gaatttgatt gctggtatta tcaatcatga actaggattc
       61 tagttttgca ggaagtctat tatcaaaaat accatcaaga ttatataaga ttgatacagg
      121 aaaagtttta tttgatggtg taaatattaa tcaaatagat aaaaaaatat taagtcaaaa
      181 tttaggagta gttccacagg attcattttt attgaaccga agtattcttg ataatataac
      241 tttaaagcac gaagttactt cacaaaagat agaggaagtt tgtaaagcag ttcaaatcta
      301 tgatgaaatc atggctatgc cgatgaaatt taatactatc atctcagaga tggggtcaaa
      361 tatttcaggt gggcaaaggc aacggatagc actggcacgt gcattaataa ataatcctag
      421 tattgtaatt ttagatgaag caactagtgc attagacact attaatgagg aaagaataac
      481 aaagtatata caaagtcagg gctgtactca aataattgta gctcatagat tgtcaacgat
      541 taaggatgcg gatgttattt ttgtaatgaa aggtggtaag attgttgagt caggaaatca
      601 taagtactta atggatcttg gtggagagta ctacagctta tatacaaaaa ggaaatgagg
      661 tgtaaagaaa atgaagaaag aaaatgaata tgtaatttta acaacagcct cactaggggt
      721 gatgattgga atagtgtttg caattttttt agattttcca gttgaatatg gtatttcttt
      781 aggcttgttg aatggaatag tattgggttc gctgattgtt tacaaaaaca ataagaatta
      841 agcataattt tttgctgtaa actaaggagt agagatggct atagttgaaa ttataaatct
      901 aacaaaaagc tttaaagata ttgaagttat tcataacact taaataatag agcaactaca
      961 gtagtagctt aaaaacatga ttaaatcgct attcttagga gtagcggttt ttctttttgt
     1021 ttaatactct ttgaaaatct cttcaaacca cgtcagcttt gccttgccgt aatcaagtac
     1081 agcctgcggc tcgcttccta gtttgctctt tgattttcat tgagtataaa aagggttaag
     1141 taagtatagt aaattgaaat aagatatgaa caaatcgatt agaaaagtca aattaatttc
     1201 tagaaatatg ttagaaattg gtttgaattc cgcaatcaat ttgttcagtt tttattgcat
     1261 ttcattttat ttaattagat tttccaattt tttaattcaa gctaaaaatc cccaatcgta
     1321 gtgattgagg attgagtaaa taaatcttaa acaatacctt gtgcaatcat ggcatttgct
     1381 acattttcaa aggcagcaat gttagctcct gcaaggtagt ctttatcaag accgtatgtt
     1441 tctgaagtcg ttttagctgt gttgaagatg tttgtcatga tgtctttgag acggccatca
     1501 acttcttcac gagtccatga gaggcgaaga ctgttttggc tcatttcaag agctgaaacg
     1561 gctacaccac cagcgttggc agcttttgca ggtccgtaga agataccatt ttctttgtaa
     1621 actttgatgg catcaaggtc gcttggcatg ttggcacctt cagatacaca gataacgcct
     1681 tgagcaacca aacgtttagc tgcttcaccg ttgatttcgt tttgagtggc acatggaaga
     1741 gcaatgtcat agtttccagc gtaagtccat acagtacctt cgtggtaggt tgcagttgct
     1801 ttttcagctg catactcagt caaacgagca cgacgttttt ctttaacatc aaccaaaaga
     1861 tcgaagtcga taccattttc atcgatgaca taaccatttg agtcagaaac agaaataaca
     1921 gttgcaccga gttcagttgc tttttgaaga gcatattgag caacgttacc agaacctgaa
     1981 ataacgactt tcttaccagc aaagctgtta ccgttagctt tgagcatttc ttcagtatag
     2041 taaaccaaac cgtaaccagt tgcttctgga cgaatcaagc taccaccaaa tccaagaggt
     2101 ttaccagtca agacaccagc atcaaattgg ttaagacgtt tgtattgacc gtaaaggtaa
     2161 ccaatttcac gtccaccaac accgatatca ccagcaggta cgtcaagtga tggtccgatg
     2221 tgtttttgca attcagtcat gaagctttgg cagaagcgca tcacttcagc atctgtttta
     2281 cctttaggat cgaagtctga tccaccttta cctccaccga taggaagtcc agtcaagaca
     2341 tttttaaaga tttgttcaaa tccgaggaat ttcaagatcc cttggtttac agttgggtgg
     2401 aaacgaagtc cgcctttgta tggtccaaca gctgagttga attgaacacg gtaaccgcgg
     2461 tttacttgaa cttttccatc acggtcaacc caaggaacac ggaaagaaac cacgcgctca
     2521 ggctcagtaa tacgtgccaa gatattttct tcgatatact cagggtgttt ttcaaataca
     2581 ggttctaaag tgttgaaaaa ttcttcaaca gcttggagga attcagcctc gtgcccgtta
     2641 cgagctttca cagtttcaaa cacgctttgg atatattctt tagcagatgt catatcgttc
     2701 tccttttatt gtcatatttt attacataag acattatagc agaatttttt ttcactgtaa
     2761 agaaaaaaca gaaattttct aaaaattctt tcaattcagt tttttggttt ttttgaaaat
     2821 agataaaaaa acgaacgttt ttcttggaaa tatctttctc aaagacaaaa tcttaaagta
     2881 tgctataaga aaagaaaatg tttagcaatt cagaaatcac ttgttaattt atccgtgata
     2941 tgttagattt gccagtaaaa ctatgagcat tttggagaaa agcaatattt agactagact
     3001 aaaataaaaa agtattatat aatagtgata tgaaatcaac taaagaagaa atccaaacca
     3061 tcaaaacact tttaaaagac tctcgtacag ctaaatatca taaacgcctt caaatcgttc
     3121 tatagtaaaa cgaaacaaga acagagcaaa tcgatcagga cagtcaaatc gatttctaac
     3181 aatgttttag aagtagaggt gtactattct agtttcaatc tactatattt cgtctgatgg
     3241 gcaaatctta taaagagatt atagaacttt tagactgtaa tcaaacaacg atttggcgaa
     3301 atgtaaaaaa atatgaggag ttcggactcg actctctcct tcaagaaaca cgtggtggtc
     3361 gtaatcatgc atatatgaca gttgaggaag agaaagcctt tcttgctcgc catttgaagg
     3421 ctgcagaggc aggagaattt gttacaattg atgccttatt tcaggcttat aaaaaggagt
     3481 gtggatgaac gcctttttag aagagctttc acaagcttat ccttttactc gttatggaca
     3541 atgctatatg gcataaatca agtaccttaa atattccgac taatattgat tttaccttta
     3601 ttcctccata cacaccagag atgaacccat tgaacaagtg tggaaagaga ttcgtaaacg
     3661 tggatttaag aataaagcct ttcgaacttt ggaagatgtc atgaatcaac tccaagatgt
     3721 tatacaagga ctggagaagg aggtgataaa gtccatcgtt aatcggagat ggactagaat
     3781 gctttgtgaa agcagatgag tataagtcct cgttttgaaa ccttagagca ggccattgcc
     3841 tccaaagatt tggaaaaagt ccgagaagct tttaagaaaa tgaattccac ttggaccatc
     3901 aatgaaagtg tggttcgtga caatagtaca gctcattatg gacgtgttga aacagctatt
     3961 tccttcctgc ctagtagcat ggaaaccgaa cctacagatg agtctggaac atgaaaacag
     4021 cagttgattt caagaaacaa aaaagaacag tcgaaactgt tcttttatca ttatttgaga
     4081 ccgtattttt tgttgaaacg atccacgcgt ccatctgctt gagtgaactt ttgacgtcca
     4141 gtgtagaatg ggtgtgagtc tgatgaaatt tccacacgga tcaatgggta agtttcgcct
     4201 tcgaactcaa ctgtttcgtt agagcgtttt gttgaaccgc taaggaattg gtaaccagta
     4261 gttgtgtcca tgaagacaac tgggcgatat tctggatgga tatctttttt cattttgcaa
     4321 tatttccttt ctgccatggt ctctttgcga gccatagatt gttaccatac tagtctatca
     4381 gattctgaaa agtttggcaa gtattttatc agtttttaag caagtttttt aacttttggt
     4441 agatgatttc gttttcttct aggctatagg aattagcacc acttgctaga gggtggcctc
     4501 caccatcatg ctccttggca atttcattga taggatggat tttactgcgt aagcgaactc
     4561 ggtagtggcc atcagcctgt tcgacaaaaa ttccccagag actcactctg tcaatgcgtc
     4621 caggtgcacc gacaatggct gcagtttcag catcggttac attgtattgt ttcaagactt
     4681 cttgactcag gataacgcga gcagcaccat tttcatccac ttccagatgg tcgtagatgt
     4741 agccttgcag tttagcaatt ttgtagctca tagtgtccat tttgcgagtg agagccgcaa
     4801 agtcaaagtt atgttctctc aaataagcag ccaggcgaag agtccgtgca gtggtagaag
     4861 ggtagaggaa gcgacctgta tcaccgacaa ttcctgcaaa gagcaactca gcatcgcgat
     4921 ctgccaaggc tagttgggtt gtttgggcaa atagggtaat catctcgcta gcgctacttg
     4981 aactagtatc gacccaagac aggtcaccgt atacatcatc atttggatgg tggtcaatct
     5041 taatgagaaa atcaccttga ctatagcgct tatcatcgat acgagcagta ttagctgtat
     5101 cacagacgat gacaagtgcg ccttggtagg ctctatcttc aacaagatcc atctcagcca
     5161 tccaagtaag agttggttca tcaaaaccga cggctttgat ggttttttct gggaaatgat
     5221 gttccagcaa ggctttcaat cccacctgac ttcccaaggc atcagggtct ggtttcatat
     5281 gacgatgaat gataatggtg tcgtattctt taattttttc taaaatttgt tggcaaatct
     5341 ccataaataa cctcaattct ttctcatttc attgtagcac aagaattttt atttttaaaa
     5401 tgaaaaagat gtgatataat ggagaaagat aaattgagga ggacgatatg gcattagcaa
     5461 aaattgtatt tgccagtatg accggtaata ccgaagaaat tgcagatatt gtagcagaca
     5521 aattacgtga cttgggcttg gatgttgatg ttgatgaatg tacaactgtt gacgcttcag
     5581 acttcttgga agcagacatc gctatcgttg cgacctatac ttatggtgat ggtgaattgc
     5641 cagatgagat gatggacttc tacgaagatc tagcagatct caacttgaat ggcaaaatct
     5701 acggagtggt cggctcagga gataccttct acgatgaatt ctgtaaggct gttgatgact
     5761 ttgaccgtgt ctttgtttca acaggagcag aaaaaggttc tgagtgtgtc aaagttgatc
     5821 tttctgccga ggaagaagat attgaacgct tggaacaatt cgcagaagaa ttggttgcta
     5881 aagtaggata agcataaaag tgcgctgatg taatcaatca gtgcattttt cttatcgaga
     5941 gttgggattt tactagccta attgatggct ttttgataca ataattcaaa taaaggagga
     6001 gactgtatgg atttagatat tattcgtcaa gaaatcgatc aaatcgacga ccaaattgtc
     6061 aaactgttag aagaacgaat gcatttagtt gagggggtgg ttgcttataa gaaagcttca
     6121 ggtaaaccga ttttagatac taagagagaa gaagttattt ttgaaaaggt tgggagtcgt
     6181 gtagaggaca agcgctatca ggagactatt gtagcgactt tttcggacat actcaaacgt
     6241 tcgcgtgatt atcaggatca aaatatcaaa tgaaaaaaga acaattttat ccgctaggaa
     6301 tttttctagc tgctatgttg ggcggacttg tccgatatct agtttccacc tggttaccag
     6361 ccagtccaga ctttccttgg ggcactctct ttgtcaacta tctgggaatt ttctgcttga
     6421 tttttcttgt caagggctat ctggtctata aggggactag taagggcttg attttagcac
     6481 tggggacggg tttttgcgga ggtttaacaa ctttttccag cctaatgctt gatactgtga
     6541 agctgcttga tacagggcgt tattttagtt tagtcctgta tttgcttttg agcatcggtg
     6601 gaggcctact cttagcttat tttctaggga ggaagaaatg gtaatcgtct atcttgcaat
     6661 cgcctgtggc ttgggagcac tcgtacggta tttcttttct cgctataatc aagcttctaa
     6721 attgccactc ggaacgctca tagctaatct tttaggttgt tttttaattg gagtatttta
     6781 caatcatgta gagtctaagg aagtatatgc tattctagca acaggatttt gtggcggttt
     6841 aacaactttt tcgaccttga atgacgaact tcaaagactg ctaagtgata agaaggtctt
     6901 ttattcttac ctgactttga cttacatagg tggtttggtt gcgatttttt taggaatttt
     6961 gctataaatt tctttacttt tttttagaaa tttggtaaac tatatcttgt gtgtaatgga
     7021 cgcacaaaaa tacagtttat ccgctgagga agattcctca agattgacaa agataggaga
     7081 ataaaatgaa tccattaatc caaagcttga ctgaaggtca acttcgtaca gatatcccat
     7141 cattccgtcc tggtgacact gttcgtgtac atgcgaaagt tgtcgaaggt aaccgtgaac
     7201 gtatccagat ttttgaaggt gttgttatcg cacgtaaagg tgctggaatc tcagaaaact
     7261 acacagttcg taaaatctct aacggtgtag gtgttgagcg tatcttccca atccacactc
     7321 cacgtgttga aaaaatcgaa gttgtacgtt acggtaaagt acgtcgtgcg aaattgtact
     7381 acttgcgtgc tcttcaaggt aaggcagctc gtatcaaaga aatccgtcgt taattcgact
     7441 aaaaaactct gctttttcag cagagttttt atctagctcc cttagttcaa tggatataac
     7501 aactccctcc taaggagtag ttgcaggttc gattcctgca gggggcatgt aattagacat
     7561 caaaaaccgc tcagctgagc ggttttagtc tattctttcc ttttacagta cccatgttcg
     7621 gatggcgtgg gcaacgccgg attcgtcatt tgttttagtg atgtatttgg cgattttttt
     7681 gatttctgga tttccatttt ccatgacaac ggggtttcca acgacttcca gcatggcacg
     7741 gtcattttct tcgtcaccga ttgccatggt ttcatctttg gtcaatccga gtttttcagc
     7801 caagtgagta atggctgaac ccttgtctac attcttttta aggagttcga ggtagaaagg
     7861 agcagatttg ttgatggagt agcgctcgta aaattctgct ggaatttttt caatcgcagc
     7921 atcgagaatt tctggttcat cgataaacat acatttaaca atttctttgc cagccatttc
     7981 ttcaggggta cggtagaaga taggcatgct gacgagggtt gattcgtgta cagtgtattt
     8041 tccgatattg cgatttgcag tatagatacc gtccttggta atggcatgca tgtggacacc
     8101 gagcttgcga ctgaggaatt ccatatctag ataatcctca taagtcaagg attcgctgat
     8161 aatctcatgt cctgtagcag tttcttggac aagggcaccg ttgaaggtta ccacatagtc
     8221 cccctcgtct ctcaactgca agtcgtctag aagtttggca acgcctgcga tagggcggcc
     8281 agttgcaatc acgactttga caccagcttc tttggcatct tggatggcag aaaaaacttc
     8341 aggagtgatt tccttttggc tgttgacaag ggttccgtcg atatcaacgg caattagttt
     8401 aatactcata aatttcctct tctagttttt atttggggta aaatgatcgt tctcaatcaa
     8461 gtataaaaat tgctgggtaa tgctagcaaa gatactgttt tgatctaaca tttctttcgg
     8521 aaaatagaaa cgattatctc cgtgacgact accagcaagg gattggacga taggagacag
     8581 gctagagagt tcggccagtt ctccattctt ttgtaaaatc tcaatctgtg tccgtggatt
     8641 ttcagattcg ggacgataga tatcataagg gaggtcaaag ttcttatgaa tggcagtata
     8701 gtagtcggga tcaaagccaa tgtcctcaac caattttctc atgctagcga gttggtcttg
     8761 atcttcttgt gaaaaggtaa tggatttaaa gaccttgcgg ttgacaaagc gttgcgataa
     8821 atctgcgaga attttgtcag gactggtcat ccagagctgg aagtaggtat tcatcacacc
     8881 atcatctaga gccagatagt cagacaaggt cacatttttt tcaaagaaag gcaggaggtg
     8941 tggggaagtt cgtgtaaaga agtctttgtc cttagggtag agttccttag cgcgcttgag
     9001 aagattctgt aggagaactt ccatagcgcg tgttgctggg tggaaataga cctgcatata
     9061 catctggtag cgactgagga catagtcttc gatggcgtgc atgccattgc gctgaaaggc
     9121 gataccattt tcgataggac gaatgactcg gaggattcga gtcaggtcaa attccccata
     9181 ggatgctcct gtaaaatagg agtcacgcaa gagatagtcc atgcgatctg cgtcaatctg
     9241 actagaaatg agttgtacga cctgcttgtt aggataggta tggtctatga cactggcaac
     9301 tttctctgga aaatcgggcg ctacttgtag caagacttgg tgaatctctg tctcaggact
     9361 ttgaataatc tcctgagtaa tagcttcatg gtctgtatca aagagatgtt caaaagtatg
     9421 ggagtaggcg ccatgcccaa ggtcatgtag gagagcagcg atcatggtca agagagactc
     9481 ggcaggattc cattcctcag gatatttttc ttcgaaaatc tctgtgatgc gtcgtgcaat
     9541 ttcatagact cctagacagt gagagaagcg actgtgttct ccaccgtgga aggtataact
     9601 ggaagttccc agttgtttga tccggcgcaa acgctgaaat tcttttgtat taatcaagtc
     9661 atagatgatt tgattattga catggatgta gttgtgaact gggtcacgga atactttttc
     9721 gttcatatga ccattatagc aaaatcctgc tctttttggt aaaatagtag gacaagagac
     9781 aagaaagagg gcctgatgtg aagattcgga tgcgaaatac gattcagttt gatgagcagt
     9841 tggaagtgat tgaccagctt tatgatgtgg aagtgcatga aaaaagagat tatagctacc
     9901 tgcttttcta taatgaggaa aaggaaaaag tagtgattaa atttcatggt caagaacttg
     9961 tgatgagccg attttctaat cccaagacca ttatgcgctt tctaaaggat agcgatagtt
    10021 tagcctatat tcttacacct atgggcatgc aggagtttac catccaaacg agccattatc
    10081 aagttgatag gcaaaagatt gaactagatt atcaactaca aaatcaagag ggacatccct
    10141 ttgccagcta tcaattggaa attacttggg gctaggctca tgtctttttc aaatttagct
    10201 atctatcttc ttggatcggc ttcctagtgt ggtagattag gctaattttt ggtataataa
    10261 aagttatgga aatcgaaaaa accaatcgta tgaatgcgct ctttgaattt tatgcggcgc
    10321 ttttgacaga taagcaaatg aattatatcg agctctacta cgctgatgat tacagccttg
    10381 ctgaaattgc cgaggagttc ggtgtcagtc gtcaggctgt ctatgacaat atcaagcgaa
    10441 cagaaaagat tctggaagat tatgagatga aattgcacat gtactcggac tatattgtcc
    10501 gcagtcagat ttttgatcag attttggagc gctatcccaa ggatgacttt ctgcaggagc
    10561 agatagaaat tttaacaagc attgataata gagaataaga ggaagaaaaa tggcatttga
    10621 aagtttaaca gaacgtttgc agaacgtctt taaaaatcta cgtaaaaaag gaaaaatctc
    10681 tgaatctgat gtccaagagg caaccaaaga aattcgcttg gccttgctcg aggccgacgt
    10741 tgccttgcct gttgtaaagg actttatcaa gaaagttcgt gagcgtgcag tcgggcatga
    10801 ggtcattgat acgcttaatc ctgcgcaaca gattattaaa atcgttgatg aagaactgac
    10861 agccgtttta ggttctgata cggcagaaat tatcaagtca cctaagattc caaccatcat
    10921 catgatggtt ggtttacaag gggctggtaa aacaaccttt gctggtaaat tggccaacaa
    10981 actcaagaaa gaagaaaatg ctcgtccttt gatgattgcg gcggatattt atcgtccagc
    11041 tgccattgac cagcttaaga ccttgggaca acagattgat gtgcctgtct ttgcacttgg
    11101 aacagaagta ccagctgttg agattgtacg tcaaggtttg gagcaagccc aaactaatca
    11161 taacgactat gtcttgattg atactgcggg tcgtttgcag attgatgagc tcctcatgaa
    11221 tgagcttcgt gatgtgaaag cattggctca accaaatgaa atcttgcttg tcgttgatgc
    11281 tatgattggt caggaagcag ccaatgttgc gcgtgagttt aatgctcagt tggaagtgac
    11341 tggggtcatc cttaccaaga ttgatggcga tactcgtggt ggtgctgctc tgtctgttcg
    11401 tcacattact ggaaaaccaa tcaagttcac tggtacaggt gaaaagatta cggacattga
    11461 aaccttccac ccagaccgca tgtctagccg tatccttggt atgggggata tgctcacttt
    11521 gattgagaaa gcttctcagg aatacgatga acaaaaagcc cttgaaatgg ctgagaagat
    11581 gcgcgaaaac acctttgatt ttaatgattt catcgatcaa ttagatcagg tgcaaaatat
    11641 ggggccgatg gaagacttgc tcaagatgat tccaggtatg gccaacaatc cagcccttca
    11701 aaacatgaag gtggatgaac gccagattgc tcgtaaacgt gccattgtgt cttcgatgac
    11761 acctgaagag cgtgaaaacc cagatttgtt aaatccaagc cgtcgccgtc gtattgctgc
    11821 tggttctgga aatacattcg tcgaagtcaa taaattcatc aaggacttta accaggctaa
    11881 acagctcatg cagggtgtta tgtctgggga tatgaataaa atgatgaagc aaatggggat
    11941 taatccaaat aaccttccta aaaatatgcc aaatatggga ggaatggata tgtctgccct
    12001 tgaaggaatg atgggacaag gcggtatgcc tgacttatca gctctcggag gagcaggaat
    12061 gccagatatg agccagatgt ttggtggcgg tttgaaaggt aaaattggtg aatttgccat
    12121 gaaacagtcc atgaaacgta tggctaacaa aatgaagaaa gcgaagaaga aacgcaagta
    12181 agacaagaga ttgatgcaaa tctcatttga tgagaaaata aagtaaaaat ttctatgata
    12241 aaacgtacag tatcaaggtt ttagaatatc tgatattata cgttttttga ttttaataat
    12301 tttgttaaga cacttttatt atggtatgcg aaaaatccac tcagctgtct gagtggatta
    12361 ggtgtattta gactcttagt ctttattttc gtatggcaag atcaagttca agatgattcc
    12421 tgtcatggct gaaagggcag tacctgaaag tgtaactgga ccaagtttaa ggatagctcc
    12481 tccaagtcca agaaccaaca tagcacttgc gatgatgagg tttcgcattt gagcgaaatc
    12541 aacacgttct ttaatcaaga ctttcaaacc attgctggcg ataaccccat agagaaggat
    12601 tgacatacca ccaagtacag cgtttggaat agttgaaatc aaggcagtga atttaccaag
    12661 gaagctgagg gcaatcgcga tgaaggcagc gttacggata actgagacag aagcgatacg
    12721 agtcataccg ataacccctg tattttctcc gtaagttgta ttggctggtc caccaaggaa
    12781 ggcagaaaca gaagttgcga taccgtcacc aataagagta cggtgaagac ctggttcttt
    12841 taagaattga cggccacaga tttgacccaa aacagtatgg tctccgatat gttcagaaat
    12901 tgttacgata gcgattggca agatagcgat ggcttctgga ccaaagtaaa gattgtactc
    12961 tttaaaggca ccacctgtgc taaatggcaa gtagaaacca ggaatttcga accagttggc
    13021 tttaagaact ggtgtaaagt caaccaagcc aagagttagt gcgaaaaggt aaccaccgat
    13081 aatggcaaag aggaatggaa tgattcgtag gaagcctttt ccttttgtat tgataaaggc
    13141 agcaattagg aaagtaacaa cggctaccag agcatttttc caatttccgt ctgctacaag
    13201 acctgcattg gtaacagctg aacctgcaag tccaagaccg ataacgatga tcataggacc
    13261 gataatgatt ggtggcaaga gtttatcaat ccattttgtt cctacaaatc ggatgctggt
    13321 agcaacaagg acatagacca aaccagtcaa gataacccct gtttgggcag cagatacatc
    13381 accccccatt tctttcatag ccagtgacat agctgtgata aaggcaaatg aagaacctag
    13441 ataaactgga actttaaaac cagtagcaat catgtagatg agtgttccaa cacctgaagc
    13501 aaaaagggca acagatacag gcattcccaa aatcaatggt accaagatgg tcgcaccaaa
    13561 catggcgaaa acgtgttgga agctaaggag aattcctttt ccatccgaag gacgttggtc
    13621 aacgtctagt aacaaatcaa cagttgattc ttgtttcata taaacctcac ttttgggcat
    13681 cagaaaagag cccattattt tacagcaata ggccctcaga gtaagacttc tctaaaatct
    13741 agactttaaa gagtttcaaa tatttttgcg tcttcgtcac ctcacgggat gacattaaaa
    13801 acctttgctt aggatagtat agcagaaaaa aatgattttg taaatcattt tttcccgagc
    13861 ctagaaataa aagagcgagg ctgattttgt aaacatttgt ttactaaaaa atttaaagtg
    13921 ggcgtttatt tggcatacca gccttacgtg gatatttatt tggtgtttct tttttctttt
    13981 ctaccactgt gatatagcgc ggatctctat tcggtagggc gtagctgaga ttgtcttcga
    14041 ccttactaaa aaggagattg agggcattct tagcttctaa taattcctca ggcgcattgc
    14101 tggccttgag tgccaatagt ttgccaccaa ccttaaggta gggaatagtc aattcagata
    14161 ggacctgcat acgggcaacc gcacgagctg ttacaaaatc atattgagca cggaagttct
    14221 tgtcttgggc aaaatcttcg gcacgtccgt ggtagaaatg aactccgttc aaatccagtt
    14281 cttgagccaa gagttgtagg aagttgatgc gcttattgag tgaatcaata atggtcacat
    14341 ctaactccgg atagagaatt ttcattggta gactaggaaa tcctgcccca gccccgatat
    14401 caagaagttt gatagtttca ttgggaatca aaccttgaag aatgggtgca atcgaatcgt
    14461 aaaaatgttt gagataaact tcttccttgt ccgtaatcgc cgtcaaatta atcttctcat
    14521 tccactcgac caagagctca aaataacgtt caaattgttc tttttgctgg tccgaaagtg
    14581 gaagattctg ctcggcaagc aagttgtaaa atgtttttgg tttcatagtt atttccttct
    14641 ttagtatcat cttattttac cacaatcata gaaaatttga tatactggta ctaatctaaa
    14701 agcagaaagg acttatatta tgacttggat tattcttgga gttttagctc ttgttgttat
    14761 ttttgtgatt gttagctata acggtttggt taaaaatcgt atgcaaacca aggaggcttg
    14821 gagtcagatt gatgttcagt tgaaacgtcg aaatgacctc ttgccaaact tgattgagac
    14881 tgtaaaaggt tatgccaaat atgaaggttc tacccttgaa aaggtggcag aactacgtaa
    14941 ccaagtggcg gcagcgactt caccagcaga agctatgaaa gccagtgatg ccctcactcg
    15001 tcaggtttca ggtatttttg cagttgcaga aagctatcca gatttgaaag ctagtgctaa
    15061 ctttgttaaa ttgcaagagg agttgacaaa cacagaaaat aaaatttctt actctcgtca
    15121 actctataac agtgttgtca gcaactacaa tgtaaaatta gaaactttcc cgagcaatat
    15181 tatcgctgga atgtttggat ttaaagcggc agatttcctt caaacacctg aagaggaaaa
    15241 gtcggttcct aaagttgatt ttagcggttt aggtgactaa gatgttgttt gatcaaattg
    15301 caagcaataa acgaaaaacc tggattttgt tgctggtatt tttcctactc ttagctcttg
    15361 ttggttatgc ggttggttat ctctttataa gatctggact tggtggtttg gttatcgcac
    15421 tgattatcgg ctttatctac gctttgtcta tgatttttca atcgacagag attgtcatgt
    15481 ccatgaatgg agcgcgtgag gtggatgagc aaacggcacc agacctctac catgtagtgg
    15541 aagatatggc tctggtcgct cagattccta tgccccgtgt tttcatcatt gatgatccag
    15601 ccttaaatgc ctttgcgaca ggttctaatc ctcaaaatgc ggctgttgct gcgacttcag
    15661 gtctactagc tatcatgaat cgtgaagaac tagaagctgt tatgggacat gaagtcagtc
    15721 atattcgtaa ttatgatatc cgtatttcga ctattgcagt tgcccttgct agtgctatca
    15781 ccatgctttc tagtatggca ggtcgtatga tgtggtgggg tggagcaggt cgcagacgaa
    15841 gtgatgatga ccgagatgga aatggtcttg aaatcattat gctagtggtt tccctactag
    15901 ctattgtact ggcacctctc gctgcaacct tggttcagct cgctatttct cgtcagaggg
    15961 aatttctggc agatgcatct agtgtcgagc tgactcgcaa tccccaggga atgattaatg
    16021 ccctagataa gttggacaat agcaaaccta tgagtcgcca cgtcgatgat gctagcagtg
    16081 ccctttatat caatgatccc aagaaaggtg gggggttcca aaaactcttt tatacccacc
    16141 cacctatctc agaacggatt gaacgtttaa aacatatgta aaatgaaggc tggaaaaaag
    16201 tctttaaaat ctgaaaaacg cataatatca ggtgtgaaaa cttgatatta tgcgttttac
    16261 tatgggaaga tttacttctt tttctcctaa aattgtgttt ttgccccacc tatctgctat
    16321 gttgcaaatt tataaatctt ctaaattaac tagcttcaaa ccgtgttctg tcatgcgata
    16381 gatgatcgag cagacttctt ttaagaaacg acggtcatgc gaaacagtga tgagaccgcc
    16441 aggataagtg gcaaagagtt ttctgatttg gggttgagaa gtgggagaaa agtttcgtgt
    16501 gggttcatcc agcaggagaa agtttggttt gcgcaggact aaatccaaaa gcaggagttt
    16561 tccctgttgt ccgccagata aggagcgaat ttgatgctgc atttctggat aactgaaatt
    16621 gagactagct aggtgagatt ggattttctg tagttcctct ttttccccag ttttactgag
    16681 ataggctatt ggggataaat ccaattgcag ttttttgtgg taatcttgtg gcataaaacc
    16741 aagtgaaatc tctcttttat cattcagaag tctctgtaac ttggctaaca gagttgattt
    16801 cccaacacca tttggcccga taataccgat tttttcttgg ccacggacag ttagttgtag
    16861 tttttgaacc aaaactcggt cgtcaatgga caaattttct ttttccagtt ggactaagac
    16921 tttagaagct ggtaatggtt ggatgtctga aaagaaaagt tggatttgtt cctcttcaag
    16981 tggcttttga gtcatggact gagctgcctt ttcgtagcgt ttttcttgtg agaggacagt
    17041 tttcatcttt ttagccaata ggcgaccggc agtactatct ttggtagctc gaagcgcagt
    17101 ttctacactt tgcttgactc tccgatgttt ttccatggtt ttatcgtagg ctctttggtt
    17161 gttagcagct tgctgacttt gtttggcaaa attagccttt ctctgctcac tatagctatc
    17221 atagtctaaa tgctctacta gcgtttccgc ttctttacgg tgtttgacca gtcgcaagtg
    17281 aacaatagtg tctgccgttt cagaaagaaa gtcttcatca tgggaaatga aaataacggt
    17341 ttgcctggtc ttttgaatct ggccttttag ccaatcaact gtctcaaggt ctaggtcatt
    17401 tgaaggttca tctaaaaata gaatctcaaa gggtttggct aactcatgga taagctgaat
    17461 tttcaaagct tcgccccctg atagattgcc aatcttttgg tcacttgcga aacgattgct
    17521 atcaaaatgc aattcctccg ccaaacgata gaggatactg tagtctaaat caatagaatc
    17581 taaaaagaag tagtcgtgta aagttttctt tttcagctcc tcgggaagtt tttgaggaat
    17641 gtaggccagt gactgatagt cagattggat gtttcccttg atagtgaaat cagacaaagc
    17701 ttcccccatt aaaattttaa gtaaggttga tttgccattt ccttcttcac caataatagc
    17761 aaccttttcc ccgtcttgga tggtcatgct taggtcagat acaagatctc gtaaatcttt
    17821 gttttgtgtg atggttagat gattgatttt tatcatatga tttccctttc tagaatgttc
    17881 atagtgcata acaaaaagct ctactttacc tagtagagcc caaagtctat gtcaaaaaaa
    17941 ctctattaac atgccagaaa aagagcataa aagagcacac aaaaagagac aaaaacaaga
    18001 tctactaaat aaaggttctt tatttgatag acttagttgt tcatgtctcc cttacctccg
    18061 agtattagta tctttatatt atacctttaa ggaaattttg tcaacagaaa actggaaatt
    18121 ctatgctcta aaatccaaaa acaggtccat agagacttag tacgtgtttg acatgctcgt
    18181 aatggaattt atcatagttt cgccaagcag tgcgtgcttg atcgtttagt tttaggctac
    18241 ccagtccaat cagaagactg gtgggttggt aaaatttctc aagatcaatt aagatactgt
    18301 tgttcaactt ttccgttttt tgagctcttg catagtagtg tttagcagct cttgtagtcg
    18361 aatatcatct gccgtaccct gtttacagtt ttggtagctt ttatttaact tggataggag
    18421 ttgaatgagt ttcttgtctt ccatgtgagc atcctccttg atctgatgta ctctttccct
    18481 atagtatagc actaaaaaat aaaactgtca tagtgaatat gttaaaattt cgaattttaa
    18541 ttacaaagtt tggtgtgctg atttgtagcc ttttcatggt ataatcaaga gagtaaatct
    18601 ttatggagga agtatgaaat taaatattca agaaattcgt aagcagtctg aaggtttgaa
    18661 ctttgaacaa acgttagatt tagttgatga cctgcgtgca cgtaatcaag aaattttaga
    18721 tgtaaaagat atccttgcag ttgggaaagt acaatatgaa gaccgtatgt atttcttaga
    18781 ttatcaacta tcttatacca ttgttcttgc ttcgagtcgc agtatggagc cagttgagtt
    18841 agttgaatct tatccagtca cggaagtttt catggaaggc gcaactaacc agctagatca
    18901 agaagtttta gatgatgact tggtcttgcc catcgaaaat ggggagcttg accttgctga
    18961 gagtgtatca gacaatatcc tgctaaacat tcctatcaag gtcttgacgg ctgaagaaga
    19021 agctggtcaa ggatttgtct caggaaatga ctggcaaatc atgacagagg aagaatacca
    19081 agctcaacaa gcagtaaaga aagaagaaaa cagtcctttt gctggcttac aaggactatt
    19141 tgacggagat gaataatggt cttgtcaaaa aaacgagcac gaaaggtgct agaagaaatc
    19201 atttccctct tcccagatgc caagcctagt cttgatttta ccaatcattt tgaactcctg
    19261 gttgcggtca tgttatcagc ccagacgaca gatgcagcgg taaataaggc cacaccaggt
    19321 ctctttgttg cctttccaac accccaagct atgtctgtag cgacagagag tgagattgct
    19381 tcacatattt ctcgcttggg attgtatcgg aataaagcta aattccttaa aaaatgtgcc
    19441 caacagttac tagacgattt tgatggtcaa gtccctcaga cacgtgaaga attggagagt
    19501 ttggcaggtg ttggtcgcaa gacagccaat gttgtcatga gtgtaggatt tgggattcca
    19561 gcctttgcag tggatactca tgtggagcgt atttgcaaac accacgatat tgtcaaaaaa
    19621 tcagcgacgc cacttgaggt ggaaaagcgg gtcatggata tcttgccgcc tgagcagtgg
    19681 ttagctgccc atcaggccat gatttatttt ggaagagcca tttgccatcc aaaaaatcca
    19741 gagtgtgacc agtacccaca attatatgat tttagcaatt tgtaagatac tacattgaaa
    19801 ctttttgctt gattttaagc atgctttgtg ctatagtaaa tgataactaa atattccttt
    19861 aaacctgtcc cgtgaggcag gcaaggagcg cgataaagta gaagggtgaa gtctatactg
    19921 tgtgcagtag ggctcgcttg gctataaatt tcaagtctcc ttgtttaagg agacttttct
    19981 ttttggaggt ttgtcatgaa aacaaaagaa gttgtagacg aattgaccgt caaacgagcg
    20041 attacgcgta ttacttatga gattatcgaa cgcaacaaag atttgaataa gatcgtcttg
    20101 gctggtatta aaactcgtgg tgtctttatt gcccaccgaa tccaagaacg tttgaagcag
    20161 ttagaaaatc tttcagttcc tgttgtggaa ttggatacta aacctttccg tgatgatgtt
    20221 aaaagtggag aagatacttc tttggtttct gtcgatgtga cagaccgcga agttatcttg
    20281 gtggatgatg tgctctatac aggtcgtacc atccgtgctg ctattgataa tattgtcggt
    20341 catggtcgtc ctgcgcgtgt gagtttagca gttctagtcg atcgtggaca tagagaattg
    20401 ccaatccgtc cagattacgt tggaaaaaat atcccaacca gtcgttctga agaaatcatc
    20461 gtagagatga cagaacttga tgaccaagac agagttctga ttactgaaga agcttagaaa
    20521 gttaaaggag tagccatgtc agaaaatcaa caagcattga accatgtggt gtccatggaa
    20581 gacctcactg tcgatcaagt aatgaaattg atcaagcgag gaattgagtt taaaaatgga
    20641 gcccagcttc cctatgaaga ccatccgatt gtttccaatc tcttctttga ggattctaca
    20701 cggacacata agtcctttga agtcgcagag attaaacttg gattggaacg acttgacttt
    20761 gatgtgaaga ctagttcggt taataagggt gagacacttt atgacaccat tttgactctg
    20821 tctgctttag gagtggatgt ctgtgtgatt cgccatccag aggtcgacta ctatagagaa
    20881 ttgattgcta gtccaacgat tacgacttcc atcatcaatg gtggagatgg ttcgggccaa
    20941 caccctagcc agagcttgct tgatttgatg accatttatg aggaatttgg ccactttgag
    21001 gatcttaaag ttgctattgc aggtgacttg gaccactcac gcgttgccaa atccaatatg
    21061 cagattttga aacgcttggg agctgaactc tttttcgctg gacctgagga atggagaagt
    21121 caagagtttg cagactatgg aaagtttgta accattgatg aaatcattga tcaggttgat
    21181 gtcatgatgt ttctccgtgt gcaacacgaa cgccatgata gtggagctgt attttcaaaa
    21241 gaagactacc atgcccaaca tggcttgact caagaacgtt acgatcgttt gaaagaaaca
    21301 gcaatcctca tgcacccagc tccaatcaat cgtgatgtag aaatagcaga ccacttggtt
    21361 gaagcaccaa aatcacggat tgtccaacaa atgaccaatg gtgtctttgt tcgaatggca
    21421 atcttagaat ccgtactagc gagtagaaac gccaactaaa acacaagacg ttaaaagacg
    21481 ccagtgagcg tccacgagag gtgaaaatat gacaaaaaga attctagtat tagaagatgg
    21541 cacagttttt gaaggcaagg ccttcggagc agatattgat gtaacaggcg aaatcgtctt
    21601 taatacagga atgaccggct accaagaatc cattacagac cagtcttata atggacaaat
    21661 cttgaccttt acttatcctt tggtaggaaa ttatggtatt aatcgtgatg attatgaatc
    21721 cattattcca acttgtaagg gagtcgttgt ttttgaagaa gcgcgtagag ctagcaactg
    21781 gcgcaaccaa atgaccttgg atgaattttt gaaagccaag aaaattccag ggatttcagg
    21841 aattgatacg cgtgctctta ccaagattat ccgtaagcat ggtactatgc gtgcaacctt
    21901 gacccatgtt ggggacagta tggaccatgt gacggaccag ctccaagcaa cagttttacc
    21961 gacagacaat atcaaacagg tttctactaa aacgtcttat ccagctccag gagttggttt
    22021 gagcgtggtg ctagtggact ttggtctcaa gcactcaatc ctacgtgaac tttctaaacg
    22081 caactgtaac gtgacagttg ttccttattc gacaacggct gaagaaattc tccatctcaa
    22141 tcctgacgga gttatgttgt caaatggtcc aggtaaccca gaagacgttc cacaagcact
    22201 cgacatgatt cgcggtgtac aaggaaaaat tccaatcttt ggtatttgta tgggacacca
    22261 actctttgca atggcaaacg gggctaagac ctataagatg aagtttggtc accgtggatt
    22321 caaccatgcg gtacgtgaaa tcgcaacagg acgagtagac ttcaccagcc agaaccatgg
    22381 ttatgcagtc agccgcgagg atttgccaga gcacttgatt attacccacg aagaaatcaa
    22441 tgacaagtca gtggaaggtg tgcgccacag ataccaacct gctttctctg ttcaatacca
    22501 cccagatgca gcccctgggc cacacgacgc tagctaccta tttgacgagt ttatcgagat
    22561 gatggaagtt tttaaacaat caaactaaga acgagtaaaa gctcgtcgga gaatttatgt
    22621 aactgaacac ggacggaaag ctcagaatgt agagaaacca acttggattg tcactccttc
    22681 cttgattttc taaaattcaa tcgctttcta ttcgtccttt gtatcttatt taatgtcgcc
    22741 ctgagaggcg acgaatagaa aggagaaggg tgctccgtat ttgctgaact gaatacgggc
    22801 tacggacggt gctaaaaaga tagttattcc tagaactgac agttcttcgt cataactcct
    22861 attttagctt tgtccgcttg acgcccttaa tatcttatat atgcctaaac gtactgatat
    22921 tcaaaaaatt atggtgattg gttctggtcc gattattatt ggtcaggctg ctgagtttga
    22981 ctacgctggg acccaggctt gcttgtcgtt gaaagaggaa ggttatgagg ttgttttggt
    23041 taactcaaat cctgcaacca tcatgacgga caaggaaatt gctgataagg tttacattga
    23101 accgattaca cttgagtttg tgacacgtat tcttcgtaag gaacgtccag atgccttgct
    23161 accaacactc ggtggtcaga caggtctcaa catggccatg gaattgtcta aaaatggcat
    23221 cttagatgag cttggtgtag agcttctcgg tactagattg tctgccattg accaagcgga
    23281 ggaccgtgac ctctttaaac aattgatgga agagcttgag caacccattc cagaatctga
    23341 aattgttaac acagtagaag aagcaattgc ctttgcagcg acaattggct acccagtcat
    23401 cgttcgtcca gcctttaccc ttggtggtac tggtggtggt atgtgtgcca acgagaaaga
    23461 attgcgtgaa atcactgaaa atggtttgaa attgtcacct gttacccaat gtttgattga
    23521 acgttcgatt gccggtttca aggaaattga atacgaagtg atgcgtgact cagctgacaa
    23581 tgccttggtt gtttgtaaca tggaaaactt tgacccagtt gggattcaca caggggattc
    23641 cattgtattt gcccctgcgc aaaccatgtc agactatgaa aaccaaatgc ttcgtgatgc
    23701 gagcttgagc attattcgtg ccctcaagat tgaaggtgga tgtaatgttc agctagctct
    23761 tgatcctaac agtttcaagt attatgttat cgaagtaaac cctcgtgtat cacgttcgtc
    23821 agcccttgct tctaaagcga caggatatcc gattgctaag ttggctgcca agattgcagt
    23881 aggtttgacc ttggatgagg ttataaaccc agttacaggt tcaacctatg ccatgtttga
    23941 accagccctt gactacgtag ttgctaagat tccacgtttc ccatttgaca agtttgaaaa
    24001 gggtgaacgc cgtctcggta cacaaatgaa ggcgactgga gaagtcatgg caatcggtcg
    24061 taacatcgag gaatctcttc tcaaggcctg ccgatccctt gaaattgggg tgcaccacaa
    24121 tgaaatacct gaacttgcag cagtttctga tgataccttg attgaaaagg ttgtcaaagc
    24181 ccaagatgac cgtctcttct acgtatcaga agcaattcgt cgtggctaca cacctgaaga
    24241 aattgcagag cttacaaaaa ttgatatctt ctatcttgat aaactcttgc atatctttga
    24301 aattgagcaa gaattgggtg ctcatccaca agatctagaa gttttgaaaa tagccaaact
    24361 taatggtttc tcagaccgta agattgctga actctgggga acgactgatg atcaagttcg
    24421 ccaacttcgt ttggaaaaca agattgtccc agtctataag atggtagata cttgtgcggc
    24481 agagttcgac tctgaaacgc catatttcta ttcaacctat ggttgggaaa atgaatctat
    24541 cagatctgat aaagaatctg tacttgttct aggttcaggt ccaatccgta tcggtcaagg
    24601 ggttgagttt gactacgcaa ccgttcactc tgttaaggct atccaggcag ctggttatga
    24661 agctattatc atgaactcaa acccagagac cgtttcaaca gacttctctg tatcagataa
    24721 gctttacttt gagccattga cattcgaaga tgttatgaac gtcattgact tggaacaacc
    24781 aaagggagtt atcgttcagt tcggtggtca aacagccatc aaccttgcgg agccattggc
    24841 aaaagcaggt gtgaccatcc ttggtacaca ggttgctgac ctagaccgtg ccgaagaccg
    24901 tgacctcttc gagcaagctc tcaaagaatt ggatattcca cagccaccag gacaaacggc
    24961 taccaatgaa gaagaagcag ctcttgcagc tcgtaagatt ggcttcccag ttcttgtccg
    25021 cccatcttat gtacttggtg gacgtgccat ggaaatcgtt gaaaacgaag aagaccttcg
    25081 ttcttacatg cgaactgctg ttaaggctag tccagaccac ccagttcttg tcgactctta
    25141 catcgttggg caagagtgcg aagttgatgc catttcagat ggtaaaaatg tactcattcc
    25201 tggtattatg gagcatatcg aacgtgctgg tgtccactca ggtgactcaa tggctgttta
    25261 cccaccacaa accttgtcgc aaaaggttca ggagaccatc gcagactaca ccaaacgctt
    25321 agcaatcggt cttcactgcc ttggaatgat gaacatccag tttgttatca aggatgaaaa
    25381 agtctacgtt attgaggtca atccacgtgc cagccgtacc gttccattcc tatctaaggt
    25441 aaccaatatt cctatggctc aagtagcgac caagctcatt cttggtcaaa gtttatcaga
    25501 acttggctac caaaatggac tttaccctga aagcacccgt gttcatatca aggcacctgt
    25561 cttctccttt accaaactag ctaaggtaga cagcttgctc ggtcctgaaa tgaagtcaac
    25621 aggtgaagtt atgggttctg atgctacttt ggaaaaagct ctctataaag cctttgaagc
    25681 ttcttatcta cacttgccaa cttttggtaa tgtcttcttt accatcgctg atgatgccaa
    25741 agaagaagcc ttgaacttgg ctcgtcgttt ccaaaacatt ggttatggaa tccttgcgac
    25801 agaggggaca gcagccttct ttgctagtca tggcttgcaa gcccaacctg ttggtaagat
    25861 tggtgatgac gataaggata tcccaagttt tgtacgcaaa ggaagaattc aagctatcat
    25921 taacacagta ggaacaaaac gaactgctga cgaagatggt gagcaaattc gtcgttcagc
    25981 cattgaacac ggggtgcccc tcttcacagc gctagataca gctaatgcca tgcttaaggt
    26041 acttgaaagt cgtagctttg ttacagaagc gatttaaata gaaaaaataa gatatagcag
    26101 actgaattta gaacagtaca cagggatact aaaatatttc tagaaattaa tttgaatttt
    26161 ctaattgatt tgttcgcatc ttatttcaat ctactataga aaaaagtctt taaaattata
    26221 aaacgcatca tatcaaggtt tttcaaaaaa cttgatatga tgcgttttat tgtgggaata
    26281 tgtatttcat tttctactaa aattatgttt ttgaataacc tctatcttag tagtctgtat
    26341 aatccccctc aatcagtttt tgcgataagc tttaatgcta tgactatacc actcttgcat
    26401 ttcttttgat ggtggtgtca tataatcgcc atacatctgg gttaaaaatt ggtcatattt
    26461 tttgggaaca ggcaacatac ggccctcaaa ctcagttaaa atcagttctt taaaggtatc
    26521 aactgggaag atttctttca tcccttcctt accgatccca actcctcctt catattgagg
    26581 agtgttggtt acagcatttt tgactagttg atcaattttc ttgtaaaagt agcgaggatt
    26641 gacaaatcgg agagcgtacc agctacataa tctaagaaaa tcttttagtt tgctatcacc
    26701 gtgaactgct cgtgattttt tgatataagc tagttgacga agggccacat acttatagct
    26761 cttgtcgaca atgctcaagt ctgtaaatcg atcaattggg aagacatcga tgaaaaggct
    26821 ggtatcatga cgcttgtact taacatggtc ttctataaca gtagaagtgt ccaaaatcga
    26881 tgcgaaatta tggaagtacc aagaagatgt atcgtaggaa agaactttgt agcgatggtg
    26941 attttcttct tcaataatct tcagtaaacg ctcataatcc tcacgataaa gggaaatatc
    27001 aatatcatca tcccaaggaa tcataccttt gtggcggatg gctccaagca tggttccata
    27061 actgagaaaa taaggaatat catgtttctt acaagtctca tcaatatagt ccagcagggc
    27121 tagttgaatt tctttaattt cttttttttc taaatattgc atcctaatcc tccaatttat
    27181 aagcgtgaaa ttcatgactg tagaagcgtt tttcttctgg tggtagggtc atataatctc
    27241 cataaaattg tgtcaaaata gtatcaaatt tttcaggtgc aggaaggctt aaattctcaa
    27301 agggtaaatc gattgtttta tcaaaggtac cacttgggaa gacttccttt tccttaaatt
    27361 ttgaaggaat aaaagccata tactgcccat tttcacgact atatttttga atttctttct
    27421 cgattttatt tgcaaaataa cgaggagaaa ccggtcgaag gagcaaccaa aaggctgttc
    27481 gtatccaatc ttttaaaagg ctatccttat agacaatatt tttatgttta ctgaaagaca
    27541 gcagtttgaa gctttccagt ttataacaag tatcaatgac cttaggatca tcaaagcgat
    27601 ccatagggaa aatatcgata aagataccag actcataggt ttttgtattt cgagtatcaa
    27661 taattttagt cgtactgtcg gttatcttga taaagttgtt aaagtagttc ttatcagttt
    27721 ctaaggatag gagcttatac ttgctttttt ccttttgaaa aatgttaata aatcgttggt
    27781 agtcttctct aggcatggac agatcaatat cgtcgtccca agggataaag ccctcatgtc
    27841 gaaccgcccc aatcagagta ccgtagttaa taatatagtt gatattgtgc tttttacaga
    27901 gagtatcaat ataatccaaa atttctaatt caatttgttt ggcatcttca acggttagtt
    27961 gtttcatttt aaactcctat gattttttga atttattttt taaggctagg acatggttta
    28021 aaaattcata gaaaatgcta tcttttgtga agacaagtag actaatataa gagatagctg
    28081 ataacaagac aatcaaacca gtattaatca aaaatggcaa attaatgacc atatccacag
    28141 gatacacgaa attaatcagg aaataaattc ccacaaagga aagtgaaaag agcgagtatc
    28201 gaacagtata gctaaagata tgtcccaagt ggatgagttg ttttctatgg atgaaaatga
    28261 tatagaaaac aagtagagaa gtctctgata acatagttgt cagtaagtag tattcaggag
    28321 ccacgatatg gttgaaaaag aggagactat tcaagcccaa attgagtagc ccagcaaaga
    28381 ctgtatagac tgtgatacgt ttttcatagc cattggtaaa gagaatttgg gaaccaagaa
    28441 tggtatctaa ggccagaata atcgtacgaa aagcgaagag agaggtcaag atgccgcctc
    28501 cgatatattt ttcactaccg taaagtagga tggcatttgg tcctaaaacc atgagtccaa
    28561 aactcagtgg aatgataaag aagttaaaga ttcgactacc tctattaacc agagaaacat
    28621 aggcttcttt gtctcctttc cccagatagt aactgagacg aggcacactc actccaattg
    28681 cacctgttac aaccccagct ataacggtca caattcgctg agctatggta tagtaactaa
    28741 cgttgacatc aatccctgtt ttaacgagga agaggcgatc taaaaaagtg aagagcatat
    28801 tggcattggc aaagactaac atggctgtca gagggagaaa gagtggttta aaatcactta
    28861 ggtgaatctt aacaagtttg atgtctcttt taatccaaaa ataactaatc aggtagttaa
    28921 tcagcgtcga taaactcatc acaagtgtat agacaacaat atcgtgttca tttttaacaa
    28981 ataagaaaat agagaccagc atcaggatac ggatgaaggc agttttgtaa aagagaaaac
    29041 tgtaattttc cagagcttca ttgacccatt cgattgaaaa aatctgggca atgagttgaa
    29101 tccccataac aaggtagacc tttttgacga ttggattatc agtaaagaag agaggatagg
    29161 ctaggatata gacagcagtg gtcaaaatcg tacaagcgat gcacaaataa aaaagactag
    29221 aaaaggtcct gttaagatct tttttgttat ccttgacatt actgatagcc cttaaaccgt
    29281 agttatagac accataagtt gcaaagggca agaaaaatga caaaatagtg tcgactgagt
    29341 tgaagtaacc atagtcagtt cggtccaaga cacgcgcgac ataggttcca gttaggatgg
    29401 gaaaaataat attcaagaca cgaattccca tgtaagatag agcatttaat tttatacttt
    29461 tcattcaatt tacctcgttt ttcattatat cataaagtta gctaataaga aatgaagggc
    29521 agtaagtcaa gtaatcactt tgaagtttca aatcttaagt tttaagtttt ctttaaggaa
    29581 agtatattat tctgaaggac tctaaaattt cgcagccatt tattagtaat tgctacagaa
    29641 ttcctagtca ttcctagaaa tggactagtt tctttgaata atagaactgc ataattctcc
    29701 tattctagaa ggggaggacc agtatttctt ttatgatagg actagattgt ggtataatag
    29761 agagaataag tttttttagt aagacaaagg agaaaataga tgatttatgc aggaattctt
    29821 gccggtggaa ctggcacacg catggggatc agtaacttgc caaaacaatt tttagagcta
    29881 ggtgatcgac ctattttgat tcatacaatt gaaaaatttg tcttggagcc aagtattgaa
    29941 aaaattgtag ttggtgttca tggagactgg gtttctcatg cagaagatct tgtagataaa
    30001 tatcttcctc tttataagga acgtatcatc attacaaagg gtggtgctga ccgcaataca
    30061 agtattaaga aaatcattga agccattgat gcttatcgtc cgcttactcc agaggatatc
    30121 gttgttaccc acgattctgt tcgtccattt attacacttc gcatgattca ggacaatatc
    30181 caacttgccc aaaatcatga cgcagtggac acagtggtag aagcggttga tactatcgtt
    30241 gaaagtacca atggtcaatt tattacagat attccaaatc gtgctcacct ttatcaagga
    30301 caaacacctc aaacattccg ttgcaaggac ttcatggacc tttatggatc tctttctgat
    30361 gaagagaagg aaatcttgac agatgcatgt aaaatctttg tgatcaaagg aaaagatgtg
    30421 gccttggcca aaggtgaata ctcaaatctg aagattacaa ccgtaacaga tttgaagatt
    30481 gcaaaaagta tgattgagaa agactagtaa aatgattaat caaatttatc aactaactaa
    30541 gcctaagttt atcaatgtca aatatcagga agaggctatt gaccaagaga atcatatcct
    30601 tatccgtccc aactacatgg ctgtctgtca tgcggatcag cgttactatc agggaaaacg
    30661 tgatcccaag attttgaata aaaagcttcc aatggcaatg attcacgagt catgtggaac
    30721 cgtcatttct gacccgaccg gaacctacga ggttggtcaa aaagttgtca tgattcccaa
    30781 tcagtctcct atgcagagtg atgaagaatt ctatgaaaac tacatgacag ggacccattt
    30841 cttgtctagt ggatttgatg gctttatgag agagtttgtt tctctcccta aagatcgtgt
    30901 ggtggcttat gatgctattg aagatacggt tgcagccatt acagagtttg tcagtgtggg
    30961 catgcacgct atgaatcgtc tattgactct tgctcatagc aagcgggagc ggatcgccgt
    31021 tattggagat ggaagtttag cttttgtggt tgccaatatt atcaactata ctttgccaga
    31081 atcagagatt gtggttattg gtcgtcattg ggaaaagttg gaactcttct catttgccaa
    31141 agaatgctat attacggata atattcctga agatttggcc tttgaccatg cttttgaatg
    31201 ttgtggtggt gatggtactg gaccagctat taatgacttg attcgctaca ttcgtcctca
    31261 gggaacaatt ctcatgatgg gagttagcga atataaagtc aatctcaata ctcgcgatgc
    31321 cttagaaaag ggcttgattt tggttgggtc atctcgttct ggtcgcattg attttgaaaa
    31381 tgctatccaa atgatggaag tcaagaaatt tgccaatcgt cttaaaaata tcctttatct
    31441 agaagaacct gtaagagaaa ttaaagatat tcatcgtgtc tttgcaaccg atttaaacac
    31501 agcctttaaa acagtgttta agtgggaagt ataagtactg gaggttaatt gtggagaaaa
    31561 tcattaaaga aaaaatttct tccttactta gtcaagaaga ggaagtcctc agtgttgaac
    31621 aactgggtgg aatgaccaat caaaactatt tggccaaaac aacaaataag caatacattg
    31681 ttaaattctt tggtaaaggg acagaaaagc ttatcaatcg acaagatgaa aagtacaatc
    31741 ttgaactact aaaggattta ggcttagatg taaaaaatta tctttttgat attgaagctg
    31801 gtatcaaagt aaatgagtat atcgaatctg cgattacgct tgattcaacg tcaatcaaga
    31861 ccaagttcga caaaattgct ccaatattac aaactattca tacatctgct aaggaattaa
    31921 gaggagaatt tgctcctttt gaagaaatca aaaaatacga atccttgatt gaagaacaaa
    31981 ttccttatgc caactatgaa tctgttagaa atgtagtctt ctccttagag aaaagactgg
    32041 ctgacttagg tgttgacaga aaatcttgtc atatcgattt ggtgcctgaa aactttatcg
    32101 aatcacctca aggacgactt tatttgattg actgggaata ttcatcaatg aatgatccaa
    32161 tgtgggattt ggctgccctc tttttagagt ctgaattcac ttcccaagag gaagaaactt
    32221 tcttatctca ctatgagagt gaccaaacac cggtttctca tgaaaagatt gctatttata
    32281 aaattttaca agatactatt tggagtctat ggactgtata taaggaagag caaggtgaag
    32341 attttggtga ctatggtgtg aatcgttacc aaagagctat taaaggtttg gcttcttatg
    32401 gaggttcaga tgaaaagtaa aaacggagtt ccttttggcc ttctctcagg tattttctgg
    32461 ggcttgggtc taacggttag tgcttatatc ttttcgattt ttacagattt gtcacccttt
    32521 gtggtggctg cagctcatga ttttttgagc atctttatct tactagcttt tctcttggta
    32581 aaagaaggga aagttcgcct ctcaattttc ttaaatattc gcaatgtcag tgttatcatc
    32641 ggagccttgc tagcaggccc tatcggtatg caggccaatc tttatgcagt taagtatatc
    32701 ggaagttctt tagcttcatc tgtatcggct atttaccctg cgatttcagt tctattggct
    32761 ttcttctttt tgaagcacaa gatttcgaaa aatactgtat ttggaattgt cttgattatt
    32821 ggagggatta ttgcccagac ctataaagtt gaacaggtta attccttcta cattgggatt
    32881 ctctgtgctt tggtttgtgc tattgcatgg ggaagtgaga gtgttcttag ctcctttgct
    32941 atggaaagtg aactgagtga aatcgaagcc ctcttaatcc gtcaagtgac ttcgttcttg
    33001 tcctatcttg tgattgtgct cttctctcat cagtcattta ctgcagtagc caatggacaa
    33061 ttgctaggtc tcatgattgt ttttgcagcc tttgatatga tttcctactt ggcttattat
    33121 atcgctatca atcgcttgca accagccaag gctacaggct tgaacgtgag ctatgtagta
    33181 tggacggtct tgtttgcagt tgttttcttg ggtgcaccgc tagatatgct gacaattatg
    33241 acgtcacttg tcgtcattgc tggagtttat attattatta aagaataaag gagattcgtg
    33301 tgaaagccat catcttagca gcgggattgg gaactcgctt gcgtcctatg actgaaaata
    33361 cccctaaagc cttggttcag gttaatcaaa aacctttgat tgagtaccaa attgagtttc
    33421 tcaaagaaaa aggaatcaat gacatcatca tcattgttgg ttatcttaaa gaacaattcg
    33481 attacttgaa agagaaatac ggtgttcgtc tcgttttcaa tgataaatac gctgactaca
    33541 ataactttta ctctctctat cttgtaaaag aagaattggc caacagctat gttattgatg
    33601 ctgacaatta tctctttaaa aatatgttcc gcaatgattt gacacgttcg acttatttta
    33661 gtgtttatcg tgaagattgt accaacgaat ggttcttggt ctatggagat gactacaagg
    33721 ttcaagacat tattgttgat agcaaggcag gtcgcatcct tagtggtgta tccttctggg
    33781 atgctccaac tgcagaaaag attgtcagct ttatcgacaa ggcttatgca agtggtgaat
    33841 ttgttgatct ctactgggac aatatggtta aggataatat caaagagcta gatgtctatg
    33901 ttgaagaatt agaaggcaat agcatttatg agatcgatag tgtccaagac tatcgtaaat
    33961 tagaagaaat tcttaaaaac gaaaattaaa gattccaaca tctgacaaaa tagtcggatg
    34021 ttttttgatt ttttacgaat agatagatga gtagaaaaag aaatggagtt atttatgaaa
    34081 atcacaaact atgaaatcta taagttaaaa aaatcaggtt tgaccaatca acagattttg
    34141 aaagtgctag aatacggtga aaatgttgat caggagcttt tgttgggtga tattgcagat
    34201 atctcaggtt gccgtaatcc agccgttttt atggaacgtt attttcagat agacgatgcg
    34261 catttgtcga aagagtttca aaaatttcca tctttctcta ttttagatga ctgttatcct
    34321 tgggatttga gtgaaatata tgatgcgcct gtacttttat tttacaaggg aaatcttgac
    34381 ctcctgaaat tcccgaaggt agcggtcgtg ggcagtcgtg cttgtagcaa acagggagct
    34441 aaatcagttg aaaaagtcat tcaaggcttg gaaaatgaac tggttattgt cagtggtctg
    34501 gccaagggca ttgacacagc agctcatatg gcagctcttc agaatggcgg aaaaaccatt
    34561 gcagtgattg gaacaggact ggatgtgttt tatcctaaag ccaataaacg cttgcaagac
    34621 tacatcggca atgaccatct ggttctaagt gaatatggac ctggcgaaca acctctgaaa
    34681 tttcattttc ctgcccgtaa tcgcatcatt gctggacttt gtcgtggtgt gattgtagca
    34741 gaggctaaga tgcgttcagg tagtctcatt acgtgtgagc gagcaatgga agaaggacgc
    34801 gatgtctttg ctattcctgg tagcatttta gatggactat cagacggttg ccatcatttg
    34861 attcaagaag gagcaaaatt ggtcaccagt gggcaagatg ttcttgcgga atttgaattt
    34921 taaaaatgac ctaagctaga attctaagaa aaaatcaatt ttaagagaaa atgaacccaa
    34981 catttccata ataaaacgca tattagcaag tttttaacac ttgataatat gcgttttttc
    35041 taagtggatt agtagagtag aggatttttc tcatataata ctcttcgaaa atctcttcaa
    35101 actacgtcag cttccatctg caacctcaaa acagtatttt gagctgactt cgtcagtctt
    35161 atctacaacc tcaaagcagt gctttgagca acctgtggct agcttcctag tttgcgcttt
    35221 gattttcatt gagtataagg gaaagtatag tgaattgaaa taagatgtga acaactctat
    35281 caggaaagtc aaattaattt atagaaatat tttagcagcc aaggtgcact gttatagatt
    35341 caatacacta taatttagtg taattgagaa aggagaaatg attgtgattg atgttggcta
    35401 ggttatgttc aatgattcct accgtctcaa atcttgtcag taaggaaaaa taaattcttc
    35461 aaaagtagag attacaaggc ttgtttaaga aagaattcaa agaccttgac aaataaaaat
    35521 aaaatggtta ttataagaaa tggtctgaaa tagatgatga tacttttcga aaatcttttt
    35581 acgtcagctc agctttgcct tgctgtgttt tgagcaagct acggttagct tccgagtttg
    35641 attttcattt actagaaatg aaactgatga gagatatcag tagacatttg agtcaggata
    35701 ttatggaaaa tgataaaaag agctcgtgag attggcatat cagactacta aagtattgag
    35761 tttgttagga ttttagcgac tagttagctg ggaaaggaag atatttgtga caaataataa
    35821 actgtattcg ttgatagaat ttagaaataa aatatatgaa gaattagaac tttccagaag
    35881 tgatttagcg attttactat gtgccatgct tatcgcctct atcggattaa atatggattc
    35941 gactcccgtg attattggag ccatgttaat ctctcctttg atgacaccta ttctgggagt
    36001 ggggctctct ctagctatat ttgattttaa attgttaaga aaatctttta aaatattagc
    36061 tattcaaatt cttgccagtt taatagcttc aacactttat ttttatcttt ctcccatttc
    36121 gtatgctagt tcggaaattg ttgctagaac ctctccgact atttgggatg ttctcattgc
    36181 ttttgtagga gggatagcag gtattattgg tgctaggaaa aaagagacca ataatattgt
    36241 tcctggtgtt gctattgcaa ccgccttgat gcctcctctt tgtacagtag gttatgctat
    36301 tgcttctgct aatctaaaat ttatcatagg ctcctcttac ctattcctca tcaattgtag
    36361 ctttattgtc attgcgactt atataggtgt taggttgatg atggttaaga aacattattt
    36421 taaagataat gaagaagact ctaaaatgcg taggattttg cttctagttg ctgttttgct
    36481 gatgattccg agtttcatct ctgcaacgac tttagtgaga gaaacgttga aaaaagagtc
    36541 ccttaagaaa tttatatcag agcagtttca ggggcataat attttgaaaa aaacctattc
    36601 taaaaagact cataccctaa agctaaccat ttcaggaaat tatttgacag aagaagaact
    36661 cgatatgatt tcaagtaaga gaggtgacta tggtttaagt gatgtttctg ttcaagtttc
    36721 acaattgtct gattcagaac aacttagtaa ggaagaactg gtggagtatt tcttccagta
    36781 tatcaaggat aaggaagcaa aagaaaagga aaaagctaat aagttttata cagagtctga
    36841 ggagcaataa tttcttgaga atagctggtt tctctcgtga gtcttctatg tatatcaaag
    36901 gaagactgag gttttaagta taaaactttt cttctattat agtagctaag tcttgacagg
    36961 gttcaaaaaa tggtttacac tttataaagt ttattacttt gaaaaggtgt gatactgtgg
    37021 ctacggcaac aaaaaagaaa aaatcaacag ttaaaaaaaa tctagtcatc gtggagtcgc
    37081 ctgctaaggc caagacgatt gaaaaatatc taggcagaaa ctacaaggtt ttagccagtg
    37141 tcgggcatat ccgtgatttg aagaaatcca gtatgtccgt cgatattgaa aataattatg
    37201 aaccgcaata tattaatatc cgaggaaaag gccctcttat caatgacttg aaaaaagaag
    37261 ctaaaaaagc taataaagtt tttctcgcga gtgacccgga ccgtgaagga gaagcgattt
    37321 cttggcattt ggcccatatt ctcaacttgg atgaaaatga tgccaaccgt gtggtcttca
    37381 atgaaatcac caaggatgca gtcaaaaatg cttttaaaga acctcgtaag atcgatatgg
    37441 acttggtcga tgcccaacaa gctcgtcgga tcttggaccg cttggtaggg tattcgattt
    37501 cgcctatttt gtggaagaag gtcaagaagg gcttgtcagc aggtcgcgtt cagtccattg
    37561 cccttaaact catcattgac cgtgaaaatg aaatcaatgc cttccagcca gaagaatact
    37621 ggacagttga tgctgtcttt aaaaagggaa ccaaacaatt tcatgcttcc ttctatggag
    37681 tagatggtaa aaagatgaaa ctgaccagca atgacgaagt caaggaagtc ttgtctcgtc
    37741 tgacgagtaa agacttttca gtagatcagg tggataagaa agagcgcaag cgcaatgctc
    37801 ctttacccta taccacttca tctatgcaga tggatgctgc caataaaatc aatttccgta
    37861 ctcgaaaaac catgatggtt gcccaacagc tctatgaagg aattaatatc ggttctggtg
    37921 ttcaaggttt gattacctat atgcgtaccg attcgactcg tatcagtcct gtagcgcaaa
    37981 atgaggcggc aagcttcatt acggatcgtt ttggtagtaa gtattctaag cacggtagca
    38041 aggtcaaaaa cgcatcaggt gctcaggatg cccatgaggc tattcgtccg tcaagtgtct
    38101 ttaatacacc agaaagcatc gctaagtatc tggacaagga tcagctcaag ctatataccc
    38161 ttatctggaa tcgttttgtg gctagccaga tgacagcggc cgtttttgat accatggctg
    38221 ttaaattgtc tcaaaaaggg gttcaatttg ctgccaatgg tagtcaggtt aagtttgatg
    38281 gttatcttgc catttataat gattctgaca agaataagat gttaccggac atggttgttg
    38341 gagatgtggt caaacaggtc aatagcaaac cagagcaaca tttcacccaa ccgcctgccc
    38401 gttattctga agcaacactg attaaaacct tagaggaaaa tggggttgga cgtccatcaa
    38461 cctacgcgcc aaccattgaa accattcaga aacgttatta tgttcgcctg gcagccaaac
    38521 gttttgaacc gacagagttg ggagaaattg tcaataagct catcgttgaa tatttcccag
    38581 atatcgtaaa cgtgaccttc acagctgaaa tggaaggtaa actggatgat gtcgaagttg
    38641 gaaaagagca gtggcgacgg gtcattgatg ccttttacaa accattctct aaagaagttg
    38701 ccaaggctga agaagaaatg gaaaaaatcc agattaagga tgaaccagct ggatttgact
    38761 gtgaagtgtg tggcagtcca atggtcatta aacttggtcg ttttggtaaa ttctacgctt
    38821 gtagcaattt cccagattgc cgtcataccc aagcaatcgt gaaagagatt ggtgttgagt
    38881 gtccaagctg tcatcaggga caaattattg agcgaaaaac caagcgtaat cgcctattct
    38941 atggttgcaa tcgctatcca gaatgtgaat ttacctcttg ggacaagcct gttggtcgtg
    39001 actgtccaaa atgtggcaac ttcctcatgg agaaaaaagt ccgtggtggt ggcaagcagg
    39061 ttgtttgtag caaaggcgac tacgaggaag aaaagattaa ataagaggag gggcccgaaa
    39121 gtaaatttca ggctcctttt ggttagaact tgacaaaata catcatttta tgcgaaacta
    39181 gaagaagatt attttaacta ggagaagtta tgcgtcttat ctatctgata attggttttt
    39241 tatcactggc cttggctatt gttggggttg ttttaccctt gttgccgaca acgcctttcc
    39301 ttttgttgtc tattgcttgt ttctccagaa gttccaagcg tttcgaagac tggctttatc
    39361 ataccaagct ctatcaaaca tatgtagctg attttcgcga gactaagtct attacgcgtg
    39421 aacgaaagaa aaaaatcatc gtctctatct acgtcttgat gggaatttct atttattttg
    39481 cacctctttt accagtcaaa atcggtctgg gtgctttgac catctttatc acttattatc
    39541 ttttcaaggt cattccagac aaagaatagt taaaacagta gttatttgcc ttgataaaat
    39601 tgaaagcata ttcataataa tatgatataa taaatttgaa gtaatattca aggagaatca
    39661 aatgatttac gaattttgtg ctgaaaatgt gactttactt gaaaaagcga tgcaggctgg
    39721 agctcgtcgg attgaactct gtgataatct agcagttggt gggacaacac ccagctatgg
    39781 agtgactaag gcagcggttg aactggcagc taactacgat acaaccatca tgaccatgat
    39841 tcggccacgt ggtggtgact ttgtctataa tgacctagaa attgctatca tgctagaaga
    39901 cattcgtttg actgctcagg ctggaagtca aggggttgta tttggagctt taactgctga
    39961 taaaaagttg gataagccta atctggaaaa gttaattgct gcatcaaaag gaatggaaat
    40021 tgtctttcac atggcctttg atgaactaag tgatgaagat caaccggaag ctattgactg
    40081 gctcagtcaa gccggtgtca ctcgtatcct aactcgtgct ggtgtgtctg gctactcctt
    40141 agaaaaacgt tttgttcact atcacagaat tttggagtac gctaaaggta aaattgaaat
    40201 tctaccaggt ggggggattg accttgaaaa ccgtcaaacc tttatcgacc aggtgggggt
    40261 aacacaattg catggtacta aggttgtttt ttaaaaaata gaaaggaact gctagctttg
    40321 ggtagtagtt ttcacttatg tttgaaattt ttaaatccta tcaatttaat caagaaaagg
    40381 ctcatgatta tggttttata gaaaatagcg aagtctggac atatagttgc cagattttgc
    40441 aaggtgactt tgtcatgact gtgtccatca ctgctgataa tgtgaacttt caagtctttg
    40501 accaagagac tggtgacctc tatcctcacg tttatatgga aagcatgagg ggaagttttg
    40561 tcggaaatgt ccgtgaggct tgtctggaga ttctttacca gattcggaag gcttgttttg
    40621 atgtgcaaga ttttatctgt catcagacta agcgtatcat gactcaagtt caggaaaagt
    40681 atgggaacca gttggagtat ctgtgggaaa aatcgcctga tacagctgta ttgcgccatg
    40741 aaggcaatca aaagtggtat gccgtcttga tgaaaatctc ttggaataag ctggaaaagg
    40801 gcagagaagg acaagtggaa gcagtcaacc tcaagcatga ccaagtagct aatttgcttt
    40861 cacaaaaggg gatttatcca gccttccata tgagcaagcg ctactggatt agtgtgtccc
    40921 ttgatgatac tttatcagat gaagaagtac tggaattgat agaaaaaagt tggaacttaa
    40981 cctctaaaaa atgaaatatt ttaataattt tcatgaactt tcaattagct aaatattctt
    41041 tactgaagaa attttcagaa aatataggat ttaccacacc agaggaatat ggtgccatct
    41101 tcaaatacct gattgagaat gtcaagacgg atcgtcagat catctattcg cctcactgtc
    41161 atgatgacct cggaatggca gtggcaaata gccttgctgc tgtcaagaat ggtgcaggac
    41221 gtgttgaagg gactatcaat ggtattaggg agcgagctga aaatgctgct ttggaagaaa
    41281 ttgcagtggc tctcaatatt cgccaagatt actaccaagt agaaaccagt attgtcctaa
    41341 atgagaccat caatacgtca gaaatggttt ctcgcttctc tggtattcca gttcctaaaa
    41401 acaaagccgt cgttggtggc aataccttct cccacgaatc tggtattcac caagatggag
    41461 tccttaaaaa tcctctcact tatgagatca tcacacctga attggttggt gttaagattc
    41521 tgcttggaaa attatctggt cgccatgctt ttgttgagaa actgagagaa ttggccctag
    41581 attttacaga agaggatatc aaaccactct ttgctaagtt caaggcactg gtcgataaga
    41641 agcaagaaat cacagatgca gatattcgag ctttggtagc tggaaccatg gttgaaaatc
    41701 cagaaggctt ccactttgat gatttacaat ttcaaactca tgcagataat gacattgaag
    41761 cgctcgttag cctagccaat atggatggtg agaaagtcga atttaatgcg acagggcaag
    41821 gttccgttga agcaatcttt aatgttatcg ataagttctt taaccaatct gttcgtttgg
    41881 tgtcctacac tatcgatgcg gtaacagatg gaatcgatac ccaggatcgg gttttggtca
    41941 ctgttgaaaa cagagataca gaaaccatct ttaatgcagc agggcttgat tttgatgtgt
    42001 tgaaggcttc tgctattgtc tatataaacg ctaatacctt tgttcaaaaa gagaatgcag
    42061 gtgagatggg acgcagtgtt tcttaccacg atatgcctag tgtgtaaagg agaaggctat
    42121 ggcaaagaaa atagtagctc tagcaggaga cggaattggc ccagaaatca tggaggttgg
    42181 tttagaagtt ctggaggctc tagctgaaaa aacaggtttt gactatgaga ttgacagacg
    42241 accgttcgga ggtgcagata ttgatgcagc atgacctccc ttacctgatg aaacccttaa
    42301 ggcaagtagg gaagcagatg ctatcctact agtagctatc ggtagtcctc agtatgatgg
    42361 agcagtggtt cgccctgaac aaggcctgat ggctctccgt aaggaactca atctttacgc
    42421 taatattcgt cctgtaaaaa tctttgacag tctcaagcat ttgtcactac tcaaactgga
    42481 acgaattgct ggtgtagact ttgtcgtggt gcgtgaattg acaggcggga tttactttgg
    42541 agatcatatt cttgaagagc gcaatgcgcg tgatatcaac gactatagct atgaggaagt
    42601 ggagcggatt attcgcaaag cctttgaaat tgcaagaaat cgcagaaaaa tcgttactag
    42661 tatcgataag caaaatgttc tagcgacctc aaaactctgg cggaaagtag ctgaggaagt
    42721 cgcacaggat ttcccagatg taaccttgga acatcagctg gtagactcag ctgctatgct
    42781 tatgattacc aatcctgcta agtttgatgt tattgtaacg gagaatcttt ttggagatat
    42841 tttatctgat gaatcaagcg tcttatctgg tacacttggg gttatgccat cagccagtca
    42901 ttctgaaaat ggaccaagtc tctatgaacc tattcacagt tcagcacctg atattgcagg
    42961 tcaaggaatt gccaatccta tttccatgat tttatcagtt tccatgatgt tgagagatag
    43021 tttcggacgt tatgaggatg cagagcgtat caaacgtgct gttgagacaa gtctggcggc
    43081 aggaatttta acgagagata taggaggtca ggcttcaaca aaggaaatga cggaagctat
    43141 tattgcaagg ttatgaagtt agacgaaaaa attactctag tccttttgat ttggaatgtc
    43201 atcattttct tgatttatgg tattgacaaa tctaaggcaa ggagaagagt ttggcgcatc
    43261 cctgagaaaa tcttacttat tttagccttt acttttggtg gttttggggc ctggttagct
    43321 ggaatcactt ttcaccacaa gactcgaaaa tggtacttta aaacagtttg gtttcttggg
    43381 atggtgacca cactagtagc cttatatttt atttggaggt aatggatggc agggtcttcg
    43441 agggaacacg ctgcttgggc tctagcggac tatggtttta aggtcgtgat tgcaggatct
    43501 ttcggtgaca ttcattacaa taatgaactc aataatgacc tgttgccaat cgttcagcct
    43561 agagaggtta gagagaaact agcccagcta aaaccaaccg accaggtaac tgtggacttg
    43621 gaacaacaaa aaatcatctc accagttgaa gaattcacct tcgagataga tagcgagtgg
    43681 aaacataaac tcctaaatag tttggatgat atcggtatta ccttgcagta tgaagagttg
    43741 attgctgctt atgaaaaaca acgaccagcc tactggcagg attagaaaaa atagaaaagg
    43801 aaatatagta aactgaaata agatgtaaac aaatgaatta gagcttaaca tccatttcca
    43861 gcaatttttt agaaactaca gtggactatt ctggattcaa cacattataa attatgacaa
    43921 aacacattca caagaaggct acgacatttt aaaaggtgag ggcggatgta tcgtttgccc
    43981 tactaaagtt ggttacatta tcatgaccag tgataaggca ggacttgagc gtaagttcgc
    44041 agccaaagaa cgtaagcgta acaaaccagg tgttgttctc tgcggtagca tggatgaact
    44101 ttgcgcttta gcgcaactca acccagaaat tgaagcattc tactaaaaac attgggatga
    44161 agatattctt cttggttgta tccttccttg gaaaccagaa gcctttgaaa aactcaaagc
    44221 atacggggat ggccgtgaag aacttatgac tgatgtacgt ggtactagct gttttgttat
    44281 caagtttgga aaagcaggtg aacaattggc tgccaagctt tgggaagaag gtaaaatggt
    44341 ctacgcctca tctgcttcaa tgataaaacg attgaaactc gctatgagag caaggtgtaa
    44401 tggtgtctat ggtcgataag gacggcaaac tcatcccaga acaaggagga gcacgttcaa
    44461 cttcaccagc accagttgtg atccgtaaag ggcttgacat tgataaaatc atgatgcacc
    44521 tgtcagatac ttttaactca tgggactacc gtcaggttga gtattattaa gataaaaaaa
    44581 gaagtctagt gttatgagat attaaagctc ctaacactgg actttttgtt tagaatttct
    44641 tttctttttc tataggatat ggtattctat gtagaaaata tatgttaata agtaatgcca
    44701 atatttaaac atcattagta aaaggagtta gattgatgaa taaaagaaaa gttagtttag
    44761 aagattttta taaatggtat agtctaaata aagaagagtt attaaataag gcaactgttg
    44821 gtgaaaagtt taatgataaa ttaaaagaag agtttctcca ggaatggcct ttggatagga
    44881 ttttaacaat gtcaatcgat gaatatgtaa taggaaaggg acagcaaaat aagtctttat
    44941 gctacgctct tgagaaggga aaatacaaaa atctatttct tggaatttct ggtggctcag
    45001 cttcaaaatt tggtatttat tggaataaaa aaacaaacaa atataaagat caagctaata
    45061 atgagatttc agagttggat cagcgatttt caaaattaaa atcagatttg tatgaaatta
    45121 tcaaagaagg tattcgtttt aactttgaaa attctatttt tgatatgaaa agatcaacaa
    45181 atgaatttat tggtcgttct gctatggtga caaaattact ttgtatctat tctgagggag
    45241 atcctttctt tggtgtaaat attaatagtc agaaagaatt ttggaaccac tttgtttctc
    45301 agacaaatca aggtggacct tatctgcaaa atcataaaat aattgaactg gtgtccaaaa
    45361 cttatcctga gttggagcca tcgaaattag gaactatgct ttttgagtat tctaagcttt
    45421 ttatggaaaa taaggaagac aatagtacaa tggattcatc aaacaatttt cgtcatcaat
    45481 taactcaatc tctattaaag tctccaaacc ttatccttcg tggtgctcct ggcacaggaa
    45541 agacttatct tgctaaagaa attgccaaag aattaacgga tggcaacgaa gaccaaatcg
    45601 gatttgtaca atttcaccca tcctatgatt atacggattt tgtagaaggt ttaagaccag
    45661 tatcaaatgg ggatggagct attgagttta ggctacagga cggtattttt aaagattttt
    45721 gtcagaaagc aaaagaaccc caattgattg gaggacaaga taattttgat gaggcttggg
    45781 attcttactt agaatatata aatgttgctg aagaaaaaga atatataaca aaaacatctt
    45841 acttatctgt taatagtaga caaaatttgt cagtaaatta tgatagtggt gttccaggat
    45901 ggtcactacc tagcaaatat gtttacgagt tgtataaaga taaaaattat aataagcaag
    45961 aatactacaa aagtggtgga aaaactgtcc tagaaacatt gagaaagaga tttggtttga
    46021 aagactatgt ttccccaaca gaaattgata ctgataagaa attcgtcttc atcatcgatg
    46081 aaatcaatcg tggggagatt tctaagattt ttggcgaact ctttttctct atcgaccctg
    46141 gctatcgtgg tgaaaaagga agtgtttcta cccaatatgc aaatctacac gaaactgatg
    46201 aaaagttcta tatccccgaa aatgtttaca tcatcggaac tatgaatgat attgatcgtt
    46261 cagtggatac ctttgatttt gctatgcgtc gtcgttttcg ttttgttgaa gttactgccg
    46321 agggtcaagt tggcatgttg gataaagagc tgaatatcca tgcagaagaa gcaaaaattc
    46381 gtctaagaaa cttgaacgct gctatcgaaa atgttcagga attaaacagt cattatcata
    46441 ttggaccaag ttattttctt aagttgaagg atgtagattt tgactatgaa ttactctggt
    46501 ctgattatat taagcctctc ctagaagact acttgcgagg ttcttatgat gaggttgaaa
    46561 ctttggaaac tttgaaaaaa gcatttgaac tgacaaataa tgagcaaaaa gatcaggcag
    46621 tagctgatga caatgaaggt gatgaaaacg atgatgcgga ttactgataa ttaacacaag
    46681 attattaaag aaaaatttgt tgaagaatat cctaaactaa gcaatctcct tttagacaga
    46741 accttggaaa gtctatccca agatgaacgt attttcattt ttccaaatga tttgactcat
    46801 actcctgatt tggataagga ccaaaagatt tttgaaacag tcaatcagaa aatcaagaca
    46861 gggaacgtga ttggttttct tggatatggt caggaaagat taacaatttc ctcacgattt
    46921 tctgatgaga gtaatgacca ctttttgcat tatctcttaa acaaggttct tcatatcaat
    46981 ctcactagtt tagatgttgc tttgtctcgt gaagagaggc tttatcaact tttggtgcat
    47041 ctcttcccca agtatctaca agctgctatt cgaaaaggtc tttataagga atatcatcga
    47101 ttttctcata acgacagtca tgttaaggga gtgattgatg taagaaacca tctcaagaaa
    47161 aatcttcctt tcacgggaaa tattgcctac gcaacgagag agttcaccta tgataatccc
    47221 ctcatgcagt tggtccgtca cactattgaa tacattaaga atcagaaaag cattggtcaa
    47281 ggggtactag ataatctctc aactagtcgt gaaaacgtat ctgaaatcgt gcgtgtaacg
    47341 ccctcttata aactagctga tcgtgctaag attattcggg gaaatcaatc taaacctata
    47401 cgtcatgcat actttcacga gtacagaaac ttacaagaac tttgtctgat gatcctaaac
    47461 caagaaaagc acggtttagg gtatcaagat caaaaaatct atggtattct ctttgatgtt
    47521 gcctggcttt gggaagagta tgtttacacc ttgttgccaa aaggttttgt acatcccaga
    47581 aataaggata agacggatgg aatttcagta ttttctgttg ggaaacgaaa agtatatcca
    47641 gatttttatg acagagaacg aaagattgtt ctagatgcaa aatataaaaa actggaattg
    47701 actgaaaaag gaatcaaccg tgaggactta ttccagctga tttcctattc ttatatttta
    47761 aaagctgaga aggctggact tgtttttccg agcaaggaca aggttattga taatgagata
    47821 ggaaacctag caggttatgg agctttgttg aagaaatggt ctatccaaat tcctcagaag
    47881 tcttcatctt atagtgcatt ttgtaaaatg atggaaaatt cagaagaaaa ttttaaagcg
    47941 attattgatg aagaagtggg gagaaaataa tttcctctct ttcttttatt tttaacacaa
    48001 gtaaaacccg aacaatatat ttcaattcat aaaataattt gacaaaaact gtacttttgt
    48061 ttataataaa ttaaggaaac gtcggaaaag acgtagtgat gcgagagcat aggtaggtca
    48121 ttacaaaaga aacgagacat cgatatgtta aatgaatttc caatttttga ttacgaagat
    48181 attcaattga ttccaaataa atgtgtcatt aaaagccgtg cagaagcgga tacaagtgtc
    48241 actttaggaa atcacacctt taaactacct gttgtgccag cgaatatgca gacgattttg
    48301 gatgaaaatg tagcagagca actggctaaa ggtggttact tctacattat gcaccgtttt
    48361 gatgaggcag gacgcattcc ttttattaaa cgcatgcacg atcaagggct cattgcttct
    48421 atctctgtcg gtgttaagga ttatgagtat gattttgtta gccagctcaa ggctgatgct
    48481 cctgagtata tcactattga tattgctcat ggtcatgcgg atagcgtgat ttctatgatt
    48541 caacacatca agaaagaatt gccagatacc tttgtcattg ctggaaatgt gggaacacca
    48601 gaagctgtgc gtgaattgga aaatgctggt gcggatgcta ctaaggtcgg aattggtcct
    48661 ggtaaggttt gtatcaccaa ggttaagact ggttttggta caggtggttg gcagttggct
    48721 gctctacgct ggtgtgccaa ggctgcgcgt aaaccgatta tcgctgatgg aggaattcgt
    48781 actcacggtg atattgccaa gtctatccgc ttcggtgcta gcatgatcat gattggttcc
    48841 ctctttgcag gacacattga aagtccaggg aaaacgattg aagtcgatgg tgaacagttc
    48901 aaagaatatt atggttcagc ctcacaatat cagaaaggtg cttacaaaaa tgtggaaggc
    48961 aaacgtatct tgcttcctgc taaaggtcat ctgcaagaca ctttaactga gatggaacaa
    49021 gaccttcaaa gtgctatttc ttatgcaggt ggacgtcagg ttgctgacct taaacacgtt
    49081 gattatgtga tcgtgaaaaa ctccatctgg aatggggatg cttcccacta agacggggtc
    49141 tttgaccaaa aaacttgtta ttagagcaaa tttctgttat aataaaacaa gtttccaccc
    49201 ttagtgtaat ggatatcacg taagattccg gttcttgaga tgggggttcg attccctcag
    49261 ggtggatgta aacatcctaa aaagccttta atagggcttt tttctttatc ctgacccaaa
    49321 tttgccgcta aaactgagaa tctctgtcta aagaattccc aaatgctttc cagtcccgtt
    49381 ttagagtgac tcagggggct ttttttgata taataaaaag gactattatc agttagaaag
    49441 aagttggtat gaaagaatta caaactgtac taaagaatca ttttgaaatc gaatttgcag
    49501 acaaaaagtt actggaaact gcctttactc atacgagtta tgccaatgag caccgcctct
    49561 taaaaatttc acacaatgaa cgcttggaat ttttaggaga cgctgttcta cagttattga
    49621 tttcagaata tctatataaa aaatatccta aaaagcctga aggtgaccta tcaaaactcc
    49681 gtgctatgat tgtccgtgag gagagtttag ctggttttgc gcgtgattgc cagtttgacc
    49741 agtttatcaa gttgggtaaa ggggaagaaa aatctggtgg tcgcaatcgt gacaccattc
    49801 ttggtgatgc ctttgaagcc tttcttggtg cccttctttt ggataaggat gtggcaaagg
    49861 tcaaggaatt tatctaccaa gttatgattc ctaaggtaga agcaggcgaa tttgagatga
    49921 ttacagacta taaaacccat ctccaagagt tgcttcaggt caatggtgat gtggctattc
    49981 gttatcaagt gatttctgaa acagggcctg ctcacgataa ggtctttgat gtagaagttc
    50041 ttgttgaagg taagagcatc ggtcaaggcc aaggtcgttc taagaaatta gcagagcagg
    50101 aagctgccaa aaatgccgtt gagaaagggc tggattcatg tatttaaagg aaatcgaaat
    50161 tcaggggttc aagtcttttg ctgataagac caaggtcgtt tttgaccaag gtgtgacggc
    50221 agttgttgga cccaatggat ctggaaagtc caatattaca gaaagtctgc gttgggcttt
    50281 gggggagtct agtgtcaaga gtctccgtgg gggcaagatg ccggatgtca tctttgctgg
    50341 aacagaaagt cgcaaaccgc tcaattatgc ttctgtagtt gtgactctgg ataatcatga
    50401 cggatttatc aaggatgcag gtcaagaaat cagggtggaa cgccatatct atcgtagtgg
    50461 agatagcgaa tacaagattg acggcaagaa agtccgtctg cgtgatattc atgacctctt
    50521 cttggatact ggattgggac gagattcctt ctctattatt tcccaaggga aggttgagga
    50581 gatttttaat tccaagcctg aggaacgacg agctattttt gaagaagctg ctggagtttt
    50641 aaaatacaag actcgcagaa aagaaaccga gagtaaactg cagcaaactc aggataatct
    50701 ggaccgctta gaggacatta tctacgagtt ggataatcaa atcaagcctc ttgagaagca
    50761 agctgagaat gcccgtaagt ttttagactt ggaaggacaa cgtaaggcta tttatttaga
    50821 cgttctggtt gctcaaatca aggaaaataa ggcagaacta gagtcgacag aagaagagtt
    50881 ggctcaggtt caagaactct tgatgagtta ttaccaaaag cgtgaaaaat tagaagaaga
    50941 aaatcaaact cttaaaaagc aacgccaaga tttacaggct gaaatggcca aagaccaagg
    51001 cagtttgatg gacttgacta gtctgattag tgatttagaa agaaaattag ccctatcgaa
    51061 actggagtcc gagcaagtgg ccctgaatca acaggaggca caagctcgtt tggctgcttt
    51121 ggaggataag agaaattcac tcagcaaaga aaagtatgat aaagaaagct ctttagctct
    51181 gttagaggga aatctagtcc aaaataatca aaaactcaat cgtttagaag ctgaattgct
    51241 ggctttctca gacgatcctg atcagatgat tgagctctta cgtgaacgct ttgtagctct
    51301 tttacaagaa gaagcggatg tctcaaacca gttgacccgt attgagaatg agttggaaaa
    51361 tagtcgtcag ctttctcaaa aacaagcaga tcaactagaa aagctgaaag agcaattagc
    51421 tacagctaaa gagaaggcta gtcagcaaaa agacgagctt gaaactgcca aggtgcaggt
    51481 tcagaaatta ttggctgact atcaagctat tgccaaggag caagaggagc agaaaacttc
    51541 ctatcaagct caacaaagtc aactctttga ccgtctggat agtctcaaaa acaagcaggc
    51601 cagagctcaa agtttggaaa atatcctgag aaatcatagt aacttttatg caggtgttaa
    51661 gagtgttctc caagaaaaag atcgcctagg tgggattatt ggtgcagtca gtgagcatct
    51721 gacctttgat gtttattatc aaactgccct agagattgcc ttaggggcaa gtagccagca
    51781 tatcatcgta gaagatgaag agtcggcaac caaagctatt gatttcctca aacgaaacag
    51841 agtcggtcgt gcaacctttc ttcctttgac cactattaag gcgcgtacga tttctagtca
    51901 gaaccaagat gctatcgctg taagcccagg tttccttggg atggcagatg agttggtgac
    51961 ttttgatact agactggaag ccattttcaa gaacttgcta gctacgacgg ctatctttga
    52021 taccgtagaa catgcgcgtg aagctgctcg acaagttcgt tatcaggttc gtatggtgac
    52081 attggatggg acagaattac gcacgggtgg ttcctatgcg ggtggtgcca atcgccaaaa
    52141 taacagtatt ttcatcaagc cagaactgga gcaattacaa aaagaaattg ctgcagatga
    52201 agcaagcttg ggttcagaag aagcggcttt gaagaccttg caagaccaga tggctgcatt
    52261 gacagaaaga ttagaagcca tcaaatctca aggagagcag gcacgtattc aggagcaagg
    52321 cttgtccctc gcttatcagc aaactagtca gcaagttgaa gaactggaaa ctctttggaa
    52381 actccaagaa gaggaaatag atcgtctttc tgagggagat tggcaagcgg ataaggaaaa
    52441 atgtcaagag agccttgcta ctatcgccag tgaaaagcaa aatctggaag ctgagattga
    52501 agaaattaag tctaataaaa acgccatcca agaacgctat caaaatttgc aggaagaggt
    52561 ggcgcaagct cgcttgctta agacagaact gcaagggcaa aaacgttatg aagtagctga
    52621 tattgagcgt ttaggcaagg aattggacaa tcttaatatc gaacaagaag aaattcagcg
    52681 catgctccaa gaaaaagttg acaatcttga gaaggttgat acagaattgc tcagtcaaca
    52741 ggcggaagaa tccaaaactc agaaaacaaa tctccaacaa ggtttgattc gcaagcagtt
    52801 tgagttggat gatatagaag gtcaactgga tgatattgcc agtcacttgg atcaagctcg
    52861 ccagcagaat gaggagtgga ttcgcaagca aacacgtgct gaagccaaga aagaaaaggt
    52921 cagcgagcgc ttgcgccatc tacaaaatca attaacagac cagtaccaga ttagctatac
    52981 tgaagcacta gaaaaggcac atgaattgga aaacctcaat ctggcagagc aagaggtgca
    53041 ggatttagag aaggctattc gctcattggg acctgtcaac ttggaagcta ttgaccagta
    53101 cgaagaagtt cacaaccgtc tggactttct aaatagtcag cgagatgata ttttgtcagc
    53161 gaaaaatctg ctccttgaaa ccattacaga gatgaatgat gaggtcaagg aacgctttaa
    53221 atcaaccttt gaagctattc gtgagtcctt taaagtgacc ttcaagcaga tgtttggcgg
    53281 aggtcaggca gacttgatat tgactgaggg cgacctttta acagctggtg tggagatttc
    53341 tgttcaacct ccaggtaaga aaatccagtc gcttaacctc atgagtggtg gtgaaaaagc
    53401 tctatcggct cttgccttgc ttttctccat tattcgtgtc aagaccattc cttttgtcat
    53461 cttggatgag gtggaagctg cgctggatga agccaatgtt aaacgttttg gggattacct
    53521 caaccgcttt gacaaggaca gccagtttat cgttgtaacc caccgtaagg gaaccatggc
    53581 agcggctgat tccatctatg gagtgaccat gcaagaatcg ggtgtttcaa agattgtttc
    53641 agttaagtta aaagatttag aaagtattga aggatgacaa ttaaactagt agcaacggat
    53701 atggacggaa ccttcctaga tgggaatgga cgctttgata tggatcgtct caagtctctc
    53761 ttggcttcct acaaggaaaa agggatttac tttgcggtgg cttcgggtcg gggatttctg
    53821 tctctggaaa aattatttgc tgatgttcgt gatgacatta ttttcatcgc ggaaaatggc
    53881 agtttggtag agtatcaagg tcaggacttg tatgaagcga ctatgtctcg tgacttttat
    53941 ctggcaactt ttgaaaagct gaaaacgtca ccttatgtag atatcaataa actgctcttg
    54001 acgggtaaga agggttcata tgttctagat acggttgatg agacctattt gaaagtgagt
    54061 cagcattata atgaaaatat ccaaaaagta gcgagtttgg aagatatcac agatgacatt
    54121 ttcaaattta caaccaactt cacagaagaa acgctagaag ctggtgaagc ttgggttaat
    54181 gaacatgtcc ctggtgttaa ggccatgaca actggctttg aatctattga tattgttctg
    54241 gactatgtcg ataagggtgt agctattgtt gaattagcta aaaaacttgc tatcacaatg
    54301 gatcaggtca tggcttttgg agacaatctt aatgacttac atatgatgca ggttgtggga
    54361 catcctgtag ctcctgaaaa tgcacgacct gaaattttag aattagcaaa gactgtgatt
    54421 ggtaaccata aggaacggtc ggttatagct tatatggagg gcttataatg gcagatataa
    54481 aattgattgc attggacttg gacgggacct tgctgactac tgataaaagg ctgacggatc
    54541 gtaccaagga aaccttgaaa gctgcgcgtg atcgtggtat caaggtcgta ttgacaactg
    54601 gtcgtccctt aaaagccatg gatttctttc tccatgagtt agggactgac ggtcaggaag
    54661 atgagtatac cattactttt aatggtggat tagttcagaa aaatacagga gaaatccttg
    54721 ataaaacagt cttttcatat gatgatgtgg cacgtttgta tgaagaaaca gagaaattat
    54781 cactgcctct tgatgccatc tcagaaggaa cagtttatca aatccaatcg gaccaagaaa
    54841 gtctttatgc caaattcaat ccagctttga cctttgttcc agtggacttt gaagacttat
    54901 ctagtcaaat gacctacaac aaatgcgtga ctgcctttgc tcaagaaccc ttggatgcag
    54961 ccattcagaa gatttctcca gaattgtttg accaatatga aatctttaaa tcacgtgaaa
    55021 tgttgctaga atggtcacca aagaatgttc ataaagcaac aggtttggca aaactaatca
    55081 gccatcttgg aatcgaccaa agtcaagtga tggcttgtgg tgacgaggcc aatgacctct
    55141 ctatgattga atgggcaggt cttggtgttg ctatgcaaaa cgctgttcct gaagtaaagg
    55201 cagccgcaaa tgtagtgacg ccgatgacca acgatgagga agctgtcgcc tgggctatcg
    55261 aagaatatgt gctaaaggag aactaagata tgggattgtt tgaccgtcta ttcggaaaaa
    55321 aagaagaacc taaaatcgaa gaagttgtaa aagaagctct ggaaaatctt gatttgtctg
    55381 aagatgttga tcctaccttc acagaagttg aggaagtttc tcaggaagaa gcagaggttg
    55441 aaattgttga acaagctgtg ttccaagaag aggaaatcca agacacagtt gaagaaagtc
    55501 tggatttaga gccagttgta gaagtttctc aaaaagaagt cgaagaattt ccacactcag
    55561 aagaagggaa tactgagttt ctagagacta tagaagaaaa taattctgaa gttcttgaac
    55621 cagaaaggcc tcaagcagaa gaaaccgttc aggaaaaata tgaccgcagt cttaagaaaa
    55681 ctcgtacagg tttcggtgcc cgcttgaatg ccttctttgc taacttccgc tctgttgacg
    55741 aagaattttt cgaggaactg gaagaactgc tgattatgag tgatgttggt gtccaagtcg
    55801 cttctaactt aacggaggaa ctacgttacg aagccaagct tgaaaatgcc aagaaacctg
    55861 atgcacttcg tcgtgtcatc attgagaaat tggttgagct ttatgaaaag gatggtagct
    55921 acgatgaaag catccacttc caagataact tgacagttat gctctttgtt ggtgtgaatg
    55981 gtgttgggaa aacaacttct atcggaaaac tagcccaccg ctacaaacaa gctggtaaga
    56041 aggtcatgct ggttgcagca gataccttcc gtgcgggtgc agtagctcag ctagctgaat
    56101 ggggccgacg agtagatgtt ccagtagtaa ctggacctga aaaagctgat ccagccagcg
    56161 tggtctttga tggtatggaa cgtgccgtgg ctgaaggtat cgatattctc atgattgata
    56221 ctgctggtcg tctgcaaaat aaggataacc ttatggctga gttggaaaag attggtcgta
    56281 ttatcaaacg tgttgtgcca gaagcaccac atgaaacctt cttggcactt gatgcatcaa
    56341 caggtcaaaa tgccctagta caggccaaag aattttcgaa aatcacacct ttaacgggaa
    56401 ttgttttgac taagattgat ggaactgctc gaggaggtgt ggttctagcc attcgtgaag
    56461 aactcaatat tcctgtaaaa ttgattggtt ttggtgaaaa aatcgatgat attggagagt
    56521 ttaactcaga aaactttatg aaaggtctct tggaaggttt aatctaatca gaagcaaaaa
    56581 tcctgcaagg cgtaaacttg caggaaattt ttttattcta agcgaccatc ttgacgatag
    56641 gtgatatctg gttgccaagt ccatttggca ccgaattttt caagtaggtc aaagctggct
    56701 tgaggtccca tgcttccagc tttatagtca tgaagtgggg caccattttc agcccagagc
    56761 ttttcaatac ggtcaatcaa cttccatgac gcacaaactt catcccagtg gctaaagtta
    56821 gttgagttgt tatttaggac atcataaatc aatttttcgt atggttctgg agaagcacca
    56881 gttgcagtcg catctgtacg gtaatcaagt gagttaggag ccaagttaaa ttcttctcct
    56941 acttgcttcc catttaggct aagagagaag ccttctgttg gttgaatata gatggtcaaa
    57001 atatttggag caagtggttc tccaaagata gaatccattt gtttaaagac gatgttgaca
    57061 tgagttcctt tttcagtcag tcgtttacct gtacggaaaa agaaaggaac accacggaat
    57121 cgatcgctgt ctacaaagaa ggcaccagat gtaaaggttt cagttgttga ttctggattc
    57181 acatttggct cgctacgata agagatgtat ttcatgccat caatcttacc agagcggtat
    57241 tgcccacgga taaagtgttc tttgagttct tcatcagttg gatgatagag gtttttaaag
    57301 accttaatct tttcagcacg aatctcgtct tttgtgaagc ttgctggttt gtccatggcg
    57361 aggagcgaaa gaagttgtag agtgtggttt tggaccatgt cacggagggc accggattgg
    57421 tcatagtagc caccacgttc ttctacaccc aagcgctccg caaaggtaat ttgaacattg
    57481 tcgataaaat ccttgttcca aacgttttca aaaatcaagt ttgcaaagcg aactgcaaag
    57541 atgctttgga tcatttcctt accaagataa tggtcgatac ggaaaatttg ttcttcgtca
    57601 aatgttgcta ggagttcgtc attcaacttg tttgcagttg cgtaatctgt accaaatggt
    57661 ttttcaacga tcaagcgctc aaaacctttg ccatcgacaa tgttttcaga tttgaggtgt
    57721 ttggcaatgg ttccaaagaa ctgaggtgcc atagacaaga agaagagctt attgtgttca
    57781 gcttggtatt tttcattaag ctcagcttgt aattgacgca aagcaatata atgttccgaa
    57841 tcattgacat catggctttg atagtagaag tggctagcaa attcttgggc ttgctcggta
    57901 ctatctgcca aatcaaggat ggactcgaca actacagatt caaaatattc cttactccaa
    57961 ggtctacggg cagttccaat aacggcaaag tgcttggaaa gattgccgga tttatatagt
    58021 ctaaaaaggg aagggtagag cttgcgttta gccaggtctc cactcgcacc gaaaattgta
    58081 acaataacct tagatgacat ctagctacct aatttctatt tttattccta gtcttgctag
    58141 gtatgaggaa acctcatttc ataaacttaa ttctaacata attttccgaa aaatcaaaaa
    58201 ttccaatacg aggtagaaaa actgcaagga aatccttaca gtttgagttt agacgtttaa
    58261 gaccttatct aagaactctt tcagacgagg gtgttgtggg ttatcaaaga tttggtcagg
    58321 tgttccgtct tcaaggaact cgccatctgc agtaaagata acgcggttgg caacctgacg
    58381 agcaaatccc atctcatggg ttacgataat catggtcatg ccttgctcag ccaattcctt
    58441 cataacgtta agtacgtctc caaccatctc agggtcaagg gcagaagttg gttcatcgaa
    58501 gagcatgatg tctggattca ttgctaggcc acgagctatg gctacacgtt gtttttgacc
    58561 acctgatagg ctatctggat tggcattagc tttatctgct agtccaacct tttcaagcaa
    58621 ctccattccc aatttctcag cttcttcctt agtcatcaac ttgtgctcaa taggagcaaa
    58681 ggtgatgttg tccaatacag acatatgagg gaagaggttg aagtgttgga ataccatgcc
    58741 gatattttca cggacgtggt caacattggt tgttttttca gttaaatcat agccgttcac
    58801 agtgatgtga ccgctagtga cttcttctaa aagattgagg ctacggagga aagttgactt
    58861 accagaacct gaaggaccga tgatacaaac aacatctcct tcatagaact tagtcgtaat
    58921 tccttttagg acttcatttt ttccatagtg cttgtgtaaa tcatttacat caatttttaa
    58981 ttttgccatt aacgaatcct cttttctaag cgtttcgcta gtctagtcaa aagtgtgata
    59041 attacaagat agaagatagc aaggattgca tacatcttga aactttggta gttacgagca
    59101 atgataatct taccagtttg gaagagttca accaaaccga tagcagatac gatagttgta
    59161 tctttaagag cgataacgaa ttggttgaca aagtttggca acatcaattt agttgcttgt
    59221 ggcaagataa tcttacgcat ggtttttcca taagagatac ccaagcttcg gctggcttcc
    59281 atttggccaa ctggaacggc ctgaatacca ccacgaacga tttcagcgat ataagcagcc
    59341 gcattgagtg agagggcaat ggttccagct acaaagtcgt taattgggct ttgttggcct
    59401 gtgatagact cgatgaagtt tggaattccc cagaagatga aggctgcaag aatcatcaat
    59461 ggaataccac gaataacgtc aacgaaaatc tcagagatga cgcgaagaga tttgtatggg
    59521 ctaacgctaa acataccgaa gataattccg atgacaatgg caatagcaaa tgagataaga
    59581 gctagagcaa gagtgatacc aagaccgcta aggagttgtt tgtagttgtt ttgaagcaag
    59641 ccccagagcg ttgtttcgtc aacagtactt gttgaagcag ttgaagattc gctagctagg
    59701 tatttgtcaa gaatcttttg gaattcaccg tttgctttaa ggtttgcaag tccgttgttg
    59761 aacatttcaa tcagttctgg atttgctcct tttttaacgg caaaggctgt ttcaccgatt
    59821 ggagttccag agattggagt tttcaatttt tgaccttggc tgatagaata tttgagaaca
    59881 ggttcatcat ccataacggc atcaatggca ccagtgttta aactgtcata cattgaagaa
    59941 ccatcagcaa aggttttgat tttgtagccg tatttgcttt gattttctgt taggaaggtt
    60001 tgagaagcag ttccgttttt aacaccgact gtctttcctt ttagatcttc ataagaagca
    60061 atattacttg attctttgac accaagaatg gtattagcag tgtagtatga ttctgagaag
    60121 tcaaaagttg ccttacgagc atctgtgaca gacataccag cgatgatacc atcggcttga
    60181 ccagcttgga cagcactgat agcagcatca aaaccagggt tggtgatttc aatttcaaaa
    60241 ccttggtctt tagcgattgc cttaatcaat tccatatcaa taccagtgta ttggttgctt
    60301 gaattttgga aaacaaaagg ggcaaaagaa gaatcgctgg caatgatata tttagcctta
    60361 acaggaatag cttttaatcc tgcgagagta gttgtagttg gcactgctga agatgatgaa
    60421 gcagtccatt tcttgataat tttatcaaga ctaccatctt ttttcatttc agacaaggct
    60481 tggttaaatt cagtaaccag gtgctcgtat ttacttcctt ttttcacacc gaaagcaaaa
    60541 cttcctacag cttcaccatc catttcaata tggaggtctt gaccttggtt aatggcatat
    60601 tcgataacag gtttgtcatc catcatggca tcgatggcac cagcactcaa gctgttgttc
    60661 attaaatcac cagtgtcaaa tgttttaata gtaaagccat atttatcttt gattgtttca
    60721 aggaaacgtt gagcggcagt tccgttttta acaccaacgg ttttgccagt taattggtcg
    60781 tacttgctaa ttttgtgtga ctttgtagta gcaatgacaa cttttgtatc atagtaagta
    60841 tcagacatgg tgaagacttt ttcacgttct ttagtctttg tcatccctgc catgatagcg
    60901 tcggcttgcc cagcttgaac cgcattgact gctgcgtcaa atccaggata ggacatctga
    60961 atgttccagc ctttaatctc agcgactttg ttaataatgt caacatcaat tcctttataa
    61021 gtttgatctg aatctttaaa ctcaaaaggt gcataggcgg tatcagaaac aatcttaatc
    61081 gtttctgctt tggcaatacc taatgagaaa attgggaata aaattagcaa aaatgctaga
    61141 aattttttct tcatttttag tctccttttc cgaatattct ctcattatat cagaaaaagt
    61201 aaaaaaaggc aaattgttat atttttcgtg tcagaaaata taacattgat ttttcctttt
    61261 ctttcttgaa ttgctattaa aaagtgctat aataatagta tatatagaag aaaagaggac
    61321 ggggatatga agaacaaaag aatatttaaa gacttccaag cttcaaaaat gagtttaaac
    61381 atttacacaa gcctcttgtt agcctttgtt tttgtcttca taggagagtt tgtggctttt
    61441 actttgtatg gtattggctt gttagctctc atcggacttg ctagaaattt tggagaggct
    61501 ggtcaaaatc ttgcaaccta cttgcagacc ttgcatcaga gcttgacgga taaaacaagt
    61561 gactttcgtt taattttagg attactggcc tttggtttta ttcttaacac tgtgttcaga
    61621 tggacaagaa aagttgagaa aagacctatt cgaaccttgg gattttatag agagaatttc
    61681 ctcagcaatc ttctgaaagg atttagtcta ggcttggcac tttttcttct gaccttgtta
    61741 ggtttagtgg tcttaggtca atatcgtttg gaatccattc acttgaatcc ttattctctt
    61801 gcctttgtcg tctttactat cccattttgg attttacagg ggacagcaga agaagtggtg
    61861 gcccgtgctt ggctacttcc tcaattggcc tcaagaacca atctaaaact agctattctt
    61921 atatctagcc tgttctttac cctgcttcat atgggcaatt ctggcctcac ccctctatct
    61981 ctagtaaatc tctttttatt cggagttgcc atggctcttt atcttctcaa aactgataca
    62041 gtttggggtg ttgcaggtat tcatggtgct tggaattttg ctcagggtaa tctctttggg
    62101 attttagtta gtggtcaacc gtcaggaacg tctctgatga cctttttacc acaaggcaat
    62161 caagattggc tatcaggtgg ttcttttggc atagaaggtt ccattatgac aagtctggta
    62221 ttactactgc tgattgtcta tcttgctaat aaattaaaga aagaaaatga aaggatgtga
    62281 cttcggtccg tccttttctt cgtgaaaata ctataagtat gctaaaatag gaatagcaca
    62341 tggagagagg attcttatga tcaatcacat tacagataat caatttaaac tagtatcaaa
    62401 atatcaacca tcaggagatc aaccccaagc tatcgagcag ttggtggata acattgaggg
    62461 gggagaaaaa gctcagattc tgatgggggc gactggaaca gggaagacct atactatgag
    62521 tcaggtcatt tctaaagtca ataaaccaac tctggttatt gcccacaata aaactctggc
    62581 tggtcagctc tatggggagt ttaaggaatt tttccctgaa aatgcagttg agtatttcgt
    62641 atcctactat gattattacc agccagaggc ctatgtccct tctagcgata cctatattga
    62701 gaaggatagt tctgtcaatg acgagattga caagcttcgc cactcagcta cctcagccct
    62761 tttggagcgt aatgatgtta ttgtcgtggc ctcagtctct tgtatctatg gtttgggttc
    62821 gcccaaggaa tacgctgata gtgtcgttag tctccgtcct ggtctagaga tttctcgtga
    62881 taaactcttg aatgacttgg tcgatattca gtttgaacgt aatgatattg atttccaacg
    62941 cggaagattt cgcgttcgtg gggatgtggt agagattttc ccagcttccc gagatgaaca
    63001 tgcctttcga gtagaatttt ttggagacga aattgaccgt atccgtgagg ttgaggctct
    63061 gacaggtcag gtattgggag aggtggatca tttggcgatt ttcccagcta ctcactttgt
    63121 gaccaatgac gaccatatgg aagttgccgt tgccaagatt caagcagaat tagaagagca
    63181 gttagctgtc tttgagaagg aaggtaaatt gcttgaagcc cagcgcttga aacaacggac
    63241 agagtacgat atcgaaatgc tgcgcgagat gggctataca aatggggttg aaaattattc
    63301 tcgccacatg gatggacgta gtgaaggtga gcctccttat acgcttctcg actttttccc
    63361 agatgatttt ttgattatga ttgacgagag tcatatgact atgggacaaa taaaaggcat
    63421 gtacaatgga gaccgttcgc gtaaggaaat gctagtaaat tatggtttcc gtttaccgtc
    63481 tgccttggac aatcgtcctc tccgtcgtga ggagtttgaa agccatgtgc atcagattgt
    63541 ttacgtatca gcgacacctg gtgactatga aaatgaacag actgagacgg tgattgagca
    63601 aatcattcga ccgacagggc ttttggatcc tgaggtggaa gtccgtccga ctatgggaca
    63661 gattgatgat ctcttaggtg aaatcaatgc ccgtgttgaa aagaatgaac gaacctttat
    63721 caccaccttg accaagaaaa tggcagagga cttgaccgac tatttcaagg aaatgggcat
    63781 caaggtcaag tacatgcact cggatatcaa gaccttggaa cggacggaga ttatccgtga
    63841 tctccgcttg ggtgtctttg atgtcttggt tggaatcaat ctccttcgtg aagggattga
    63901 cgttcctgag gttagcttgg ttgccattct cgatgctgac aaggaaggtt tccttcgtaa
    63961 cgagcgtgga ctcatccaga ccattgggcg tgccgcccgt aacagtgaag gtcatgtcat
    64021 catgtatgca gatacggtta cccagtctat gcaacgtgct atcgatgaaa ctgcccgccg
    64081 tcggaaaatt cagatggcct ataatgaaga gcatggtatc gtaccacaga caatcaagaa
    64141 agaaatccgt gacctgattg ccgtgaccaa ggcagttgct aaggaagagg acaaggaagt
    64201 cgacatcaat agcctcaaca aacaagagcg caaagaactc gtcaagaaac tagaaaaaca
    64261 aatgcaagaa gccgtcgaag tgcttgactt tgaactggcg gctcagatcc gtgatatgat
    64321 gttggaagtc aaggccttgg attaggggaa tagtatgatt tatttaagaa agttaaagaa
    64381 agaagatttg atgtctttat gggaaatggc ttattcacag cttaatccag tttggaaaca
    64441 gtatgatgct ccctattatg atgattatca gtatttttca aattttaaag aattcgaact
    64501 acaaaaatca gaatccattt taagcaactc aaatcgcctt ggtatttttg ttgatgataa
    64561 actagttggg actgtttcgc gttattgggt atgtaaagaa acaagatgga tggaattggg
    64621 aattggtatt tatgataaaa aattctggaa cactggtatt gggaaagttg ctatgttgca
    64681 gtggatagat aggacgtttc aggattactt ggagttggag catctgggtt tgacaacttg
    64741 gtcaggaaat cttggtatga tgaaacttgc tgaaaaatta agaatgaaaa aagaagctca
    64801 tattccaaaa gttcgttatt atcaaggtaa atattttgat agtattaaat atggtatttt
    64861 gagagaagac tgggagaaaa taaatgacgg ttattatcaa atcaatggaa actcctgaag
    64921 agatagaagg caaatccctc gttcactggc aaacgtggag agagtcttat gatgaccttt
    64981 tgcctgcgga atttcaggat acaatgacat tagaaagatg tcgattcttt agtcaaaagt
    65041 atccagaaaa tacattgatt gcgatggatg gcgtgaaggt ggttggtttt atcagttatg
    65101 gcaattttcg tgatgagact attcaagctg gtgaaattat tgctttatat gttttaaaag
    65161 actattatgg aaaaggtatc gcacaaaagt taatgaaagc agctttgact gctcttaatc
    65221 atttttctga aattttctta tgggtattga aagataacaa gcgcgccatt gctttctatc
    65281 aaaaaatggg ttttactttt gatggacaag aaaaaatact tgaacttgga aagcctataa
    65341 aggaaaaacg aatggtgttc tattctaaat aattttaaaa aagtaaaaga taatatctct
    65401 ggtagtaagt ctgaaaattt aataaattag aaagcgagta aatttatgtc ccgttcccaa
    65461 ttaacaattt taacaaatat ctgtctgatt gaagacctcg aaactcagcg cgtggtgatg
    65521 cagtatcgcg cccctgaaaa caatcgctgg tctggttatg cctttcctgg aggtcatgta
    65581 gaaaatgatg aggcttttgc ggagtctgtc attcgtgaaa tctacgaaga aacagggttg
    65641 actatccaaa atcctcaact tgtcggcatt aaaaattggc cactagatac aggtgggcgc
    65701 tatattgtca tttgttataa ggcgactgag ttctctggta cccttcaatc ttcagaagag
    65761 ggagaagttt cttgggtgca aaaagaccag attccaaact taaatctggc ctatgatatg
    65821 ctaccattga tggaaatgat ggaagctccc gacaagtcag agtttttcta tcctcgccgt
    65881 acagaagacg attgggaaaa gaaaatcttc tagtctttta ctaaataacc tagctgatcc
    65941 aaggcctcct cgatatagtg gaggtcttgt tgtgtttcgg cttcgactag gtggtaatgg
    66001 atgccatctg tcaattcaga tagaggtcta aagtcagaat gctcgacttg ttctagaaaa
    66061 tgttgcacat ctctgcgaca agacagttta agcaaggttt caatttctcc ataaacggga
    66121 tggtcaatca aggtattctg gacatgccca ccattatcga caatagcaag gagttcctga
    66181 ccgatttctt caacttcatg tttcactttg aaaagtttgt gaacataagg attggtatca
    66241 atttgcttat agatgtagcc acgattggtg gataggatag gagcgccatc ggctctcaaa
    66301 attgcaatgt cctgcacaat gacctgacgt gtgacatgaa aatgttccgc caaactttgg
    66361 ccattaaggg ctttaggagc ttctttcaag agttggagca gggcttgttt gcgatctttt
    66421 gtcatagctt ttccttttaa cggcgttttc gaagcacttt atagacagct agtgctaatg
    66481 tatagtctac catactatgg ataattgtgc caaatccaac tagcacaaat agaacataga
    66541 acatgttttc tacattggta cccgaagttg cgtaaaaaag gacacaggct aatacttcag
    66601 caagggcatg aacaacagcc aaaacaaagt tgaaaaccca ggaagatttt ggtttatcta
    66661 gggtatcggg gaatttttgt aggtaaagag ctcctaaagc accaaaagat atatgggaaa
    66721 aagcccgaaa aacgataacc atgggatagc cagccatcaa aaatccaaaa ctagaggcta
    66781 ggatgacaaa aactgccatc aagggcgaca agaacatggc tataaaaata gcgatgtggc
    66841 tccccaaagt ataggaagca ggtggaatga caatcttgaa aggcataaca attggaatca
    66901 aaatcgcaat agccgttaaa agggctgtca ttgtcataaa ttgtgtcttt ttccgtgtat
    66961 tcacaagaat ctccttttta actgcatata cactagtatg gtacaataaa ccagacaata
    67021 aagcaagaat ttacttgggt ttatagatca ttttttagtt aaaagttata gtagattgaa
    67081 actagaatag tccacctcta cttctaaaac attgttagaa atcgatttgg ctgtcctgat
    67141 caatttgtcc tgttcttatt tcgttttact tatagtaaag atttcattaa aaagaaactg
    67201 tatagagcaa aatctccacc ttcaggtttg aaagcggaga ttgtttttat tttttcaagg
    67261 tttgtagtcg tggaacaatg gctagggtta gaattgcaga aatgaccaat tcagcaattg
    67321 aatttgttga gataacggtt gccagaagaa gttggatatt tccgttataa acatttccaa
    67381 ataggaagaa gattcctcca aggacaaaga tagtatttgt caaggaacca agagccccag
    67441 ctaaaatcag accagtcttg tttttcatca gtttatagac taagtaagga gttaaaccaa
    67501 tcaaaatacg tgggacaatg gcaatgatag ctgagtagat gtttccgttt ggtacgaagg
    67561 gagagaagag gtagcttgtc ggtagaatcg taatcgtgtt aaccgtcaag ctaagtaatc
    67621 ccatcaaaaa tccaagtgta accccaactc gtggaccata aataatgctg gcaataatga
    67681 caggaatatg aacaatggtc ggtttgattg gaaatggaaa aaggttaaag ataagtgagc
    67741 tcagaaagtg tatcacgagc atggtagcaa aaaagatagc aatgggtgca atattagagc
    67801 gttttttcat cgatagtttc ctttattctt tctaaaataa ttgtgaggtc agctaaagct
    67861 cctcgtccgt ggtctccaca agctagtagg gattccttag gagcaatcag ctgatagccg
    67921 taggtttcta atgttttcag attattctga gttactggat ggtcatacat ttttgtattc
    67981 atagcaggag ctattagttt gggaatatga cttggtaggg ctagagctgt actggttacc
    68041 atgttgtccg caaatccgtg agctagtttt gcaatagtgt tagcagttgc aggtaccacg
    68101 ataaataaat ctgctttttt tccaagttcg atatgattga cctgatcagg atagggttcc
    68161 ttcatgacat ccaagtggac aggattctgt gagagtacct gtagtgtcaa aggttggata
    68221 aactctgtag cagcctgagt cattaagaca gtgacttgat ggccttgttt ttttagagaa
    68281 ctgactaaat ctgccgactt ataagaggcg attgaacccg ttacagccaa gagaatgttt
    68341 gccatagttt tcctttctaa gaatgatagg cttgaatttt ttcaaggagg agttctgcaa
    68401 tttcttcttt agtctggact gtttgaagct gatttttctc aacaaatata gctcggtgct
    68461 gacctgctga aatttgagtc aggtcattcg cgatgattaa atctgcttga ttcttgataa
    68521 gactttttcg tgcaatgtca accagatgat cttcggtaac atcaaccagc agtttgaaac
    68581 caatcagatg aatagtagga ttccattcct tgactaggga tatgattttg ggtgtctttt
    68641 taaggaacaa aacctgaacc tcatcagttg aagaaatctt ggcctgatga ttctgcttgc
    68701 ttaaaaattc ttttagattg gagctagcct gaacttcctc aagccctgtc atataaacag
    68761 gagtgtagtc agaaacagcc attgagtgga tcaagacctg ataatcctga acacgttctt
    68821 gcatttctat tagaaggtcc ttggtattgg taatttctcg aatacttagg ttaggatgag
    68881 gctctggctt cagagctcgt tttgtcgtaa ttaaacaaac ttcatgccct gcagaaagca
    68941 aagtctctgt gataattttc cccaagtgac ctgtagaatg gttagtgata gagcggacgc
    69001 tatcgatagc ttcactggta ccgcccgatg taactaaaat tttcatagca ctattgtaca
    69061 caaaaataag cggtaagtaa aatgaaagtg ataaattttt ggtaaaaacg aagatttact
    69121 atagtttcaa actataaagc catataaaat ttaagaaagg actctaaaag ccttaaaaac
    69181 agagatattt acgaacgttt agagagtttt aggatgttaa aaatcttgtt ttgtgatata
    69241 atgaattatc atataagagg ttagaggaat tttgaatgaa aacagatatt gaaatcgcac
    69301 agagtattga gttgaagcca attgttgatg ttgtagagaa acttggtatt tcttacgacg
    69361 atttggagtt gtacggaaag tacaaggcta aactcagctt tgataaaatt cgtgcagttg
    69421 agagcaatcc agtcggtaaa ttgatcttgg ttactgccat caacccaaca cctgcaggtg
    69481 aaggaaagtc gacgcttacc attggtcttg cggatgcctt gaacaagatt ggcaaaaaaa
    69541 ccatgattgc tatccgcgaa ccgtctcttg gtccagtcat ggggatcaag ggtggtgctg
    69601 ctggtggtgg gtatgcacaa gttctgccaa tggaagacat caacctccac tttactggag
    69661 atatgcatgc tattacaact gccaacaatg ccctttctgc cttgattgac aaccacttgc
    69721 accaagggaa tgagctggga attgatcaac gtcgtatcct ctggaaacgc gttgtggact
    69781 tgaacgaccg tgcgctccgc catgtgactg ttggtcttgg tggtcctcta aacggtattc
    69841 cacgtgagga tggttttgat attacagttg cttcagaaat catggcaatt ctttgcttgg
    69901 caacggacat cgaggacttg aaacgtcgtt tggcgaatat cgttattggt tatcgctatg
    69961 accgtacgcc tgtttctgta ggtgatttgc aggttgaggg tgccttggct ttgattttga
    70021 aggatgctat taagccaaac ttggttcaga caatttacgg tacacctgcc tttgtacacg
    70081 gtggtccatt tgccaatatc gctcatggct gtaactctgt tttggcgacg acaacagccc
    70141 ttcacttggc tgattacact gttactgaag ctggttttgg tgcggacctt ggtgctgaga
    70201 aattccttga tatcaagaca ccaaacttgc caacatctcc agatgcagtt gttattgtcg
    70261 caacccttcg tgcccttaag atgaatggtg gtgtggctaa agatgctctg actgaagaaa
    70321 atgtagaggc agttcgtgca ggttttgcta acttgaaacg ccacgttgaa aatatccgta
    70381 agttcggtat tccagcagtt gtagctatta acgaatttgt atctgataca gaagctgaaa
    70441 ttgcagcctt aaaagaactc tgtgccttaa tcgatgtacc agttgaattg gctagtgtct
    70501 gggctgatgg agtagaaggt ggagtagaac ttgccgaaac agttgttaag acaattgctg
    70561 aaaatccagc taactataaa cgtttgtatg ataatgacct ttctgtccaa gaaaagattg
    70621 aaaaaattgt cactgaaatc tatcgtggta gcaaagtgaa ctttgagaag aaagctcaaa
    70681 cacaaattgc tcaagtcgtt caaaacggtt gggacaaatt gccaatctgt atggctaaaa
    70741 ctcaatacag tttctcagac aatccaaatg cgcttggagc accagaaaac tttgaaatta
    70801 ccattcgtga attggtacca aaattaggtg caggcttcat cgttgcctta actggtgatg
    70861 ttatgaccat gccaggtctt ccaaaacgtc cagcagctct caacatggat gttgaaagcg
    70921 atggaactgt actaggcttg ttctagtgga ttgaaattga ctttaagtga gtttggaaat
    70981 aatatccaag ctcatttttt ctcagactgc aagcagttca tcaataagat ttatactctt
    71041 cgaaaatctc ttcaaactac gtcagcttca ccttgccgta ggtatatgat actgactctg
    71101 tcagttctat ccacaacctc aaaacagtgt tttgagcaac ctgcggctag cttcctagtt
    71161 tgctctttga ttttcattga gtataagtag atagaaaagt tatatactat ctattgaaaa
    71221 tattataaat cagatacaaa gacaggtgaa accttctgtg ttatactaga gatatgttag
    71281 atttgaaaga atacggtatc gtcatgtggc cggaggagaa agtcatttct ttccgtgaga
    71341 aacttctcgc ttggtatgat gaaaacaaaa gagatttgcc ttggaggaga agtaaaaatc
    71401 cttatcacat ctgggtatct gaaatcatgc ttcagcagac cagggtggat acagttatcc
    71461 cttactacga aagattcctg gactggtttc caactgtcga aagtctggca actgcgtctg
    71521 aggagagttt actgaaagct tgggagggct tgggctatta ttctcgagtt cgcaatatgc
    71581 aggctgcagc ccagcagatt atgactgact ttggtggcca atttccaaat acctatgaag
    71641 gaatttccag cttgaaaggg attggacctt acacagcagg agccatttcc agtattgctt
    71701 ttaacttgcc tgagccagct gtagatggta atgtcatgcg ggtcttggcg cgtctgtttg
    71761 aagtcaacca cgatattggg attccaagta atcgaaaaat ttttcaggca atgatggaga
    71821 tcttgattaa tccggatcgt ccaggtgatt ttaatcaagc cttgatggac ttagggtctg
    71881 atattgagtc tcctgtaaat cccagacctg aagaaagccc agtcaaggac tttagtgcgg
    71941 catatcagaa tggaaccatg gaccgttatc caattaaatc tcctaagaaa aagcctgttc
    72001 ctatttatct taaagcctta gttgtgaaaa attctcaagg acaattttta cttgaaaaaa
    72061 atgaaagcga aaagctcttg gcaggtttct ggcatttccc ctttatagaa gttgataact
    72121 tttcgcaaga agagcagttt gacctctttc atcaggttgc ggaagaaagt gtgaactttg
    72181 gtcccagtcc agaagagagt ttccagcagg actatgacct agatgttgat tggcttgatg
    72241 tttgttttga tacagtccag catgttttta gtcatcgaaa atggcatgtg cagattgtag
    72301 caggtcaggt gagtgacttc catgattttt cagataggga agttcgctgg ctttcaccag
    72361 aagaattcaa gaattaccca cttgccaaac cccaacaaaa aatctggcag gcttatgcac
    72421 aagccaactt agacagtagc caagactagc tattgtgtct tctgactatt tttttggtat
    72481 aatagtggag aaaaaggtga acatatgaaa aaaatactaa ttgtagatga tgagaaacca
    72541 atctcggata ttatcaagtt taatatgacc aaggaaggtt acgaagttgt aactgctttt
    72601 aatggtcgtg aagcgctaga gcaatttgaa gcagagcaac cagatattat tattctggat
    72661 ttgatgcttc cagaaattga tggtttagaa gttgctaaga ccattcgtaa gacaagcagt
    72721 gtgcccattc ttatgctttc agccaaagat agtgaatttg ataaggttat cggtttggaa
    72781 cttggggcag atgactatgt aacgaaaccc ttctccaatc gtgagttgca ggcgcgtgtt
    72841 aaagctcttc tgcgtcgttc tcaacctatg ccagtagatg gtcaggaagc agatagtaaa
    72901 cctcaaccta tccaaattgg ggatttagaa attgttccag acgcctacgt ggctaaaaaa
    72961 tatggcgaag aactagactt aacccatcgt gaatttgagc ttttgtatca tttagcatcg
    73021 catacaggtc aagtcatcac gcgcgaacac ttgcttgaga ctgtctgggg ttatgactat
    73081 tttggtgatg tccgtacagt tgatgtgact gtacgacgtc tgcgtgagaa gattgaagat
    73141 acgcccagcc gaccagagta tatcttgacg cgccgtggtg tagggtatta catgagaaat
    73201 aatgcttgat ttactgaaac aaaccatttt taccagagat tttatcttta tcctgatttt
    73261 gttaggtttc atccttgttg tgaccctctt attactggaa aatagacgtg ataatattca
    73321 gttgaagcaa atcaatcaaa aggttaaaga tttgattgca ggagattatt ccaaggttct
    73381 tgatatgcaa ggtgggtctg aaatcaccaa tattaccaat aatttgaatg acttgtcgga
    73441 ggttattcgt ctcactcagg aaaatctaga acaagagagt aagaggctaa atagtattct
    73501 gttttatatg acagatgggg ttcttgcgac caaccgtcgg ggtcagatta tcatgattaa
    73561 tgatacagcc aagaagcaac tggggttggt taaggaagat gttctgaata gaagcatttt
    73621 ggaattgctc aagatagaag aaaactatga attgcgtgat ttgattaccc aaagtccaga
    73681 attgttgcta gattcccaag atatcaatgg cgaatatttg aaccttcgag ttcgctttgc
    73741 cttgatacgt cgagagtctg gctttatttc aggtttggtg gctgttttgc atgatacgac
    73801 ggagcaggag aaggaagaac gagaacgaag actctttgtt tccaatgtta gccatgagtt
    73861 acggactcct ctgactagcg taaaatccta tcttgaagcc ttggatgagg gggctttgtg
    73921 tgaaactgta gcaccagact ttatcaaggt ttctcttgat gagaccaacc gtatgatgcg
    73981 catggtgacg gatctcctcc atctttcacg tattgataat gctaccagtc tcctagatgt
    74041 ggaactgatt aacttcactg cttttattac ctttatcctc aatcgttttg acaagatgaa
    74101 aggacaggaa aaggagaaaa aatatgagtt ggtgagagat tatcccatca attctatctg
    74161 gatggaaatt gatacagata agatgacgca ggttgtcgac aatattttaa ataatgctat
    74221 taagtattcg ccagatgggg gtaaaatcac tgtcagaatg aagacaactg aagaccagat
    74281 gattttatcc atttctgacc acggtttggg gattcctaag caggatttac cacgtatctt
    74341 tgaccgtttc tatcgtgtgg atcgtgctag aagtcgtgca caaggtggta caggtctagg
    74401 actgtctatc gctaaagaaa ttatcaaaca acataagggc tttatttggg ccaagagtga
    74461 atacggcaag ggttcaacct ttaccattgt gctcccttat gataaggatg cagtgaaaga
    74521 agaagtatgg gaggatgaag tagaagacta gaatgagtga aataggcttt aaatacagta
    74581 ttttagcgtc gggttccagt ggaaattctt tttatctgga aacctcaaaa aagaagcttt
    74641 tagtagatgc aggcttgtct ggcaagaaaa ttaccagtct gctagctgaa attaaccgta
    74701 agccagaaga cctggatgcc atcttgatta cccatgagca ttcagatcat atccatggag
    74761 taggcgtttt ggctcgcaag tatggtatgg atctttatgc caatgaaaag acctggcaag
    74821 ctatggaaaa tagtaaatat cttggcaagg tggattcttc gcaaaagcat atttttgaaa
    74881 tgggtaaaac caaaaccttt ggagatatcg acatcgagag ttttggtgta agccatgatg
    74941 cagtcgcacc gcagttctat cgctttatga aggatgataa gagttttgtc cttttgacag
    75001 atacaggtta tgtcagtgac cgtatggcgg gcattgtcga aaatgcggat ggctatctta
    75061 tcgaggccaa ccatgatgta gagattttgc gatcaggttc ttacgcttgg cgactcaaac
    75121 aacgaatcct atctgacctt ggtcaccttt ctaacgagga cggtgctgaa gctatgattc
    75181 ggacgctagg aaatcgtact aagaagattt accttgggca tttatctaag gaaaacaata
    75241 tcaaggaact ggctcatatg accatggtca atcagctggc tcaagctgat ctgggagtcg
    75301 gagtagactt taaggtttat gatacctcac cagataccgc aacaccattg acagagatat
    75361 agaaagaacg ctgagaaggt gttcttttta tattgactgg acacctaaaa agtaatacaa
    75421 tggtgttacc attaaaaaag ggagcacaaa agatgactac tattacatta aaagtttctg
    75481 aagctgataa aacatttatg aaagcaatgg ctaagtttga aggagtttcc ctttcggaac
    75541 ttattcgcac caaaactctt gaagccctag aagatgaata cgatgctcgt gtggcagatt
    75601 tagcctatca agagtattta gaagacttgg aaaaaggagt tgaacccatt acttgggaag
    75661 aaatgatgca tgatttaggc ttgaaggatg aataatttgt ataaattagt tccaacaaga
    75721 cgttttatca agcaattgaa aaaattggac cgttatacgc agaagctaat tacaaactat
    75781 ttacaaacca atgttttgga agacccaaga cgacacggaa aggctttggt tggtaatcgc
    75841 gttggtcaat ggcgctatag aattggtaat tatcgagtta tcgtacaaat tgtagatgat
    75901 gaattagttg ttgctactct agaagttggt catcggagag atatttattg aattaaagct
    75961 gagtaataac agtatagaaa gtaaggatag taaaaatttg aataaaaaat ggttatttgc
    76021 agattattat gatacaacaa ttattttact tgctttaatc tctgttattc tggtattact
    76081 tggatttgct gagatgattg atttggacaa tccgccttat agtattattg atttagtaat
    76141 ctggggtgtt tttgtaattg attatagttg gcgctttttt acgactaaaa gaaaatggcg
    76201 ctttattctt gaaaatattt ttgatttatt ggctattctc cctttaaatg ctattttcac
    76261 agtttttcga ttagggcgta tctttcgttt aactaaacta acaaaattac tgaaactgac
    76321 tcgtttactt agaataattg gacttacagg taaattagaa agaaaaatta gtagattctt
    76381 atggacaaat ggcctgattt atatcttgta tgttaatatc tttattgttc tagtagggag
    76441 ttcgatttta tccgttgttg aagaaaaatc cttctcagat agtctttggt gggctcttgt
    76501 gacagtaact actgttggtt atggtgatat tgttccagtt tccctttttg ggaaatggct
    76561 agcagtttta ctgatgcttg tcggtattgg aacaataggg gtgctaacaa gtgctttgac
    76621 gaactttttt gtaaaggata atccagatga acagataaaa cttgataaac tcaaagacga
    76681 attatcgagc caaagaatat taatagagaa acaatctgaa aaaatcgaag aactacattg
    76741 aatgataaaa gacttagttg aaaaaatatc ataaaggtga gacaaaacaa aacttgattc
    76801 gaggagaaat caagtaagtc ttgacacaat agaacgcata ttatcaggta taaaaacttg
    76861 atactatgcg ttttatagag aaataaaata aaatctgaac aaatcaatta ggaatttaaa
    76921 gcattttata acaacgtttt agagtgatgg ggtgctattt caacttcaac ctactataat
    76981 acagaaaaaa acaactccct gatgattcaa ggagttgtct atagttaaat tagtttttag
    77041 aagcttcttg gaattctgga tttttccatg cttcgtcaat aatagcttgc aattctttag
    77101 cagatgcttg cattttttga gtttctgcat cgttcaatgg aatgtttact ggacgaacga
    77161 taccatgtgc accaacaaca gctggttgac cgataaagac attctcaact ccgtattgac
    77221 cttcttggaa tactgaaagt ggaagtactg cgttttcatc gtcaaggatt gctttagtga
    77281 tacgagcaag ggctactgcg ataccgtagt atgttgcacc ttttttgttg atgattgtgt
    77341 aggctgcatc acgaacacct tcgaacaatt caatcaattc agcttcttga acattttgag
    77401 tgtctttaag gaattcttca aggtttacac cagcgatgtt agcgtgtgac caaacagcga
    77461 actcagagtc accgtgttca cccatgatgt aggcgtgcac tgaacgagca tccacatcca
    77521 atttttcagc aagtgcttga cggaaacgag ctgagtcaag tgaagtacct gaaccgataa
    77581 cgcgttcttt agggaaacca gagaatttcc aagttgagta agtcaaaacg tcaactgggt
    77641 tagcagcaac aaggaagata cctttgaaac cagattcaac aacttgagtt acgattgatt
    77701 tgttgatagc aaggttttta cctacaaggt caagacgagt ttcacctggt ttttgaggtg
    77761 cacctgcagt gatcacaaca aggtcagcgt ctgcacagtc agagtattga gctgcataga
    77821 tttttttagg tgaagtgaag gcaagggcgt gactaaggtc aagcgcatca ccaacagctt
    77881 tttcatgcaa ttgtggaatt tcgataattc caagctcttg tgcaattcct tggttaacaa
    77941 gtgcaaaagc gtaagatgaa cctacagcac catcaccgac aaggataact tttttgtgtt
    78001 gtttagttga agtcattgtt ttaaacatct ccttaatttt attaggggat tttccctaga
    78061 caacttcatt ctatcacttt taaaaaactt tgtcacgaat atgccttata gttctcgatg
    78121 taaacgtttt agtggtttag aggctgaaat agatgggaat ttatggtata atgttgttac
    78181 ttactaattg tgaaatgagg catttattaa tgcaggataa aaatttagtg aatgtcaatc
    78241 tgacaaagga gatgaaggca agttttatcg actacgccat gagtgttatc gtagcgcgag
    78301 ctcttcctga tgttcgagat ggcttaaaac ctgttcaccg tcgcattctc tacggaatga
    78361 atgaattggg tgtgacccca gacaaacccc ataaaaaatc tgctcgtatt acaggggatg
    78421 tcatgggtaa atatcaccca cacggggatt cctctattta tgaagccatg gtccgtatgg
    78481 ctcaatggtg gagctaccgt tacatgcttg tagatggtca tgggaatttt ggttccatgg
    78541 atggagatag tgctgccgct caacgttata ccgaggcacg tatgagcaag attgctctgg
    78601 aaatgcttcg tgatatcaac aaaaatacag ttgatttcgt tgataactat gatgccaatg
    78661 aacgggaacc cttggtcttg ccagcgcgtt ttccaaacct tttggttaat ggagcaactg
    78721 gtatcgcggt tgggatggca accaatattc cacctcataa tctgggtgaa accattgatg
    78781 cagtgaagtt ggtcatggat aatcctgaag tgactaccaa ggacttgatg gaagtcttgc
    78841 ctggaccaga ttttccaact ggtgctcttg tcatggggaa atcaggtatc cataaggctt
    78901 atgaaacagg taaaggttcg attgtcctac gttctcgtac agagattgaa acgactaaga
    78961 ctggtcgtga gcgtatcgtt gtaacagaat ttccttatat ggtcaataaa accaaggtgc
    79021 atgagcatat tgttcgcttg gttcaggaaa aacgcattga gggtatcacg gcagtacgtg
    79081 atgagtcaaa ccgtgaaggt gttcgatttg ttattgaagt caagcgcgac gcctcagcca
    79141 atgttattct caataacctc ttcaaaatga cccaaatgca aaccaatttt ggtttcaata
    79201 tgctcgctat ccaaaatggt ataccgaaaa ttttgtctct tcgtcagatt ttggatgctt
    79261 atattgagca ccaaaaagaa gtggttgttc gtcgtacacg ttttgataag gaaaaagcgg
    79321 aagcgcgcgc tcatatctta gaaggtctct tgattgcgct agaccatatc gacgaagtga
    79381 ttcgtatcat ccgtgctagt gaaacggatg cggaagctca agctgagttg atgagcaagt
    79441 ttaagctttc tgaacgtcaa agtcaagcta tccttgatat gcgtcttcgt cgtttaacag
    79501 gtttggaacg cgataagatt caatctgagt atgatgacct cttggctctg attgcggatt
    79561 tagcagatat tcttgctaag cctgaacgtg tttctcaaat tatcaaagac gaattggatg
    79621 aagttaaacg taaattttct gataaacgcc gtacagagtt gatggttgga caggtcttga
    79681 gtctcgagga tgaggacttg attgaagaat cggatgtctt gattaccctt tctaacagag
    79741 gctacattaa gcgtttggat caggacgagt tcactgctca aaaacgtggg ggtcgtggtg
    79801 tccaaggaac gggagtgaaa gatgatgact ttgttcgtga gttagtgtca actagcaccc
    79861 atgatcatct gctcttcttc acaaacaagg gacgtgtcta tcgtcttaaa ggttatgaaa
    79921 ttcctgagta tggtcggact gccaaagggc taccagtagt caatctcttg aaattggatg
    79981 aagacgaaag tattcagacg gttatcaatg ttgagtctga tcgcagtgat gatgcttatc
    80041 tcttctttac aacccgtcac ggtattgtga agagaactag tgttaaggag tttgccaata
    80101 ttcgtcaaaa tggtctcaaa gcgctgaatt taaaggatga agatgagtta atcaatgtct
    80161 tgttggcaga aggagatatg gatattatca ttggtaccaa gtttggttat gcagttcgct
    80221 ttaatcaatc agccgttcgt ggtatgagcc gtatcgccac tggtgtgaaa ggtgttaacc
    80281 ttcgtgaagg agacacagtt gttggtgcca gcttgattac tgatcaagat gaggttctta
    80341 ttatcacaga aaaaggatat ggtaagcgta cagtcgctac tgaataccca acaaaaggtc
    80401 gtggtggtaa gggaatgcag acagctaaaa ttaccgaaaa aaatggcttg ctggccggtc
    80461 ttatgactgt tcaaggggat gaggatttga tgattatcac tgatacaggt gtcataattc
    80521 gaaccaatct tgccaatatt tcacaaacag gacgtgcaac tatgggagtt aaagtaatgc
    80581 gcctggatca agatgctcag atagtgactt tcacaacggt tgcggtggca gaaaaagaag
    80641 aagttgggac agaaaacgaa acagaaggtg aagcataatg tctcaaaaaa ataataaaaa
    80701 gaaaaacaag cgaaaaaatc tgctgacaaa tatcctagca ggatttctga tattactgtc
    80761 actggctttg atttttaata ctcaaattcg aaatattttc atagtctgga ataccaataa
    80821 gtatcaagtt agccaggtat caaaagaaaa attagaagaa aatcaggata cagaaggcaa
    80881 ttttgacttt gattctgtca aagctatctc ttcggaagct gttctaactt ctcaatggga
    80941 tgctcaaaaa ttaccagtta ttgggggaat tgcaattcct gaattggaaa tgaatttgcc
    81001 gatttttaaa ggacttgata atgttaatct cttctacgga gctggtacaa tgaaacgcga
    81061 gcaagtaatg ggagaaggaa attatagtct agctagtcac catatctttg gtgttgataa
    81121 tgctaataaa atgttatttt ctcctttaga taatgctaaa aatggcatga agatttatct
    81181 aaccgataaa aataaagttt atacttatga aatacgtgaa gtcaaacgtg tgacaccgga
    81241 tcgtgttgat gaagttgatg atagagatgg ggtcaatgaa atcacattag taacctgtga
    81301 agaccttgct gctacagaac gtattattgt caaaggtgat ttgaaagaaa caaaagatta
    81361 ttcacaaaca tctaatgaaa tcctaacagc tttcaatcaa ccatataaac aattttatta
    81421 atacaaatca gtgaaatcca tgatttcact gattttttaa gattttcata aaaatatagt
    81481 aaaatgaaat aagaatagga cgaatcg
//
LOCUS       DBERMM010000004        77182 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.004, whole genome shotgun sequence.
ACCESSION   DBERMM010000004 DBERMM010000000
VERSION     DBERMM010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 77182)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 77182)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..77182
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.004"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..430
                     /locus_tag="ACL8AS_000359"
     CDS             <1..430
                     /locus_tag="ACL8AS_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HGS1228285.1"
                     /translation="ADNQEQLFDQVATLLEEREIVTPTYREALITREKSFPTGLDMEF
                     LGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDKEVEVSLLFFIINNSSS
                     SQTNILAQLMDFFTGNGHLEDLSKISEPEKLYAYIAEATA"
     gene            468..773
                     /locus_tag="ACL8AS_000360"
     CDS             468..773
                     /locus_tag="ACL8AS_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1228286.1"
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFRIPAMSAPVFDNIESAIKEHELS"
     gene            821..2296
                     /locus_tag="ACL8AS_000361"
     CDS             821..2296
                     /locus_tag="ACL8AS_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HGS1228287.1"
                     /translation="MDAIFDLIGKVFNPILEMGGPVIMLIILTVLALLFGVKFSKALE
                     GGIKLAIALTGIGAIIGMLNGAFSASLAKFVENTGIQLSITDVGWAPLATITWGSAWT
                     LYFLLIMLIVNVVMLAMKKTDTLDVDIFDIWHLSITGLLIKWYADNNGVSQGVSLFIA
                     TAAIVLVGVLKIINSDLMKPTFDDLLNAPSSSPMTSTHMNYMMNPVIMVLDKIFEKFF
                     PGLDKYDFDAAKLNKKIGFWGSKFFIGFILGIVIGIMGTPHPIAGVADADKWRLVIKG
                     WLSLGLTAGVSLELFSLIGSWFIAAVEPLSQGITNVATKRLQGRKFNIGLDWPFIAGR
                     AEIWACANVLAPIMLIEAVLLSKVGNGILPLAGIIAMGVTPALLVVTRGKLLRMIIFG
                     TLLLPLFLLSGTLIAPFATELAKGVGAFPEGVSQTQLITHSTLEGPIEKLLGWTIGNT
                     TTGDIKAILGAVVFLVFYIGIFAWYRKQMIKRNEEYAAKAK"
     gene            2322..2558
                     /locus_tag="ACL8AS_000362"
     CDS             2322..2558
                     /locus_tag="ACL8AS_000362"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228288.1"
                     /translation="MKIKEQTRKLAAGCSKHSFEVVDKTDEVSSKHSFEVVDETDEVS
                     SKHGFEVVDETDEVSNHIYGKATLTKFELDFRRV"
     gene            2646..9347
                     /gene="bgaA"
                     /locus_tag="ACL8AS_000363"
     CDS             2646..9347
                     /gene="bgaA"
                     /locus_tag="ACL8AS_000363"
                     /EC_number="3.2.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000515226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored adhesin/beta-galactosidase BgaA"
                     /protein_id="HGS1228289.1"
                     /translation="MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVY
                     ADETLITHTAEKPKEEKMIVEEKADKALETKNVVERTEQSEPSSTEAIASEKKEDEAV
                     TQKEEKVSAKPEEKAPRIESQASSQEKPLKEDAKAVTNEEVNQMIEDRKVDFNQNWYF
                     KLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTF
                     KLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLHKDGRENVI
                     AVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVT
                     SKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLW
                     TVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLH
                     HDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFD
                     TWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIG
                     EANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNY
                     SEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDR
                     VGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAG
                     IPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVE
                     LFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEI
                     ARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHG
                     QGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLK
                     SNQVTVFTGKKEGQEKTVLGTEVARVRTLIGKEPKMPKTVGFVYSDGSREKLPVTWSQ
                     VDVSQAGVVTVKGTANGREVEAHVEVLAIAKELPTVKRIAPNTDLNSVDKSVSYVLTD
                     GSVQEYEVDSWEITEVDKAKLSVAGSRIQMTGQLAGETIHATLVVEEGNAAAPVVPTV
                     TVGGEAVTGLTSRQPMQYRTLSYGAQLPEVTASAENADVTVLQASAANGMRASIFVQP
                     KDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPAD
                     KVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKGQVELTIQANTEKKIAQSIRP
                     VNVVTDLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQTFEVLGKVEGIDL
                     EARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYA
                     KEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVS
                     NVNDKLISYNNQPANRWTNWNRSNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVG
                     APKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHF
                     SFDKVETYAIRIRMVKADNKRGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPD
                     LTDYYLESADGKVPAVTASVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFT
                     KDKNLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLSVEWEEVPAEN
                     LTKAGQFTVRGHVLGSDLVAEVTVRVTDKLGEALSDNPNYDENSNQAFASATNDIDKN
                     SHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVAQAKLRFFA
                     DSGTDAPTKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYRADKDIAAG
                     DEINVTFKAVKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELA
                     DFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSLPVLVRLVSESGKQVKEYR
                     IHLTKEKPVSEKTVAAVQEDLPKLEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKTGK
                     ERIFTAINPDGSKEEKLREVVEAPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSE
                     ASQTNKAQLPNTGSAASQAAVAAGLALLGLSAGLVVTKGKKED"
     gene            complement(9604..9825)
                     /locus_tag="ACL8AS_000364"
     CDS             complement(9604..9825)
                     /locus_tag="ACL8AS_000364"
                     /inference="COORDINATES: protein motif:HMM:NF025126.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HGS1228290.1"
                     /translation="MNERYQNLKAKECQALLSPQGRQIFAQRKIDVEPVFGQLKACLG
                     YKRCNLRGKRQVRIDMGLVLMANNLLKYS"
     gene            complement(9794..10207)
                     /locus_tag="ACL8AS_000365"
     CDS             complement(9794..10207)
                     /locus_tag="ACL8AS_000365"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228291.1"
                     /translation="MTLDCLFIDGTKIEANANKYSFVWKKTTEKFSAKLQEQIQVYFQ
                     EEITPLLIKYAMFDKEQKRGYKQSAKNLANWHYNDKEDSYTHPDGWYYRFHHTKHQKT
                     QTDFQQEIKVYYADEPESAPQKGAIYERTLSKLES"
     gene            complement(10207..10452)
                     /locus_tag="ACL8AS_000366"
     CDS             complement(10207..10452)
                     /locus_tag="ACL8AS_000366"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228292.1"
                     /translation="MHIHYNTNQTTLPLKISSFLPQDHLVFTIEKVVNTLEDCHFHAF
                     YHAFDRPSYHLKMLVSTLLFAYSQGIFSGRKIEKWKS"
     gene            complement(10663..11022)
                     /locus_tag="ACL8AS_000367"
     CDS             complement(10663..11022)
                     /locus_tag="ACL8AS_000367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3397 domain-containing protein"
                     /protein_id="HGS1228293.1"
                     /translation="MGMILMKLASILLLILTLVVCIILTKLFRLKKLGRNFADLAFPV
                     LVFEYYLITAKTFTHNFLPRLGLTLSILAIILVFFFLLKKRSFYYPKFIKFFWRAGFL
                     LTLIMYVEMIVELFLMK"
     gene            11114..12070
                     /locus_tag="ACL8AS_000368"
                     /pseudo
     CDS             11114..12070
                     /locus_tag="ACL8AS_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002881980.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein.; internal stop;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_function: GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
     gene            12054..12611
                     /locus_tag="ACL8AS_000369"
     CDS             12054..12611
                     /locus_tag="ACL8AS_000369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HGS1228294.1"
                     /translation="MKRPLEMAHDFLAEVVTKEDVVVDATMGNGHDTLFLAKLAKQVY
                     AFDIQKQALKKTQERLHQAGLTNAQLILQGHETLDQFVTKTKAGIFNLGYLPSADKSV
                     ITRPQTTIEALEKLCHLLVKGGRIAIMIYYGHEGGDLERDAVLDFVIQLNQQEYTAAI
                     YRTLNQVNNPPFLVMIEKLERYRHG"
     gene            12604..12858
                     /locus_tag="ACL8AS_000370"
     CDS             12604..12858
                     /locus_tag="ACL8AS_000370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228295.1"
                     /translation="MDKQYLHEKLDAMRQNFVESTHHERAVGVLDQAHMSKKMLKIKK
                     KLVALEMERCQRKIEHKDCSKIDQKIKEQKEIFESCCKKD"
     gene            12870..14924
                     /locus_tag="ACL8AS_000371"
     CDS             12870..14924
                     /locus_tag="ACL8AS_000371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HGS1228296.1"
                     /translation="MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFL
                     PNTDFHLNTELFLALVIGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGL
                     AHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
                     AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIAS
                     ELLLELSLPLVTFFLAEEVHVSGIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHT
                     VTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTFVLFVIRFIMIYGYY
                     AYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTL
                     VSFLTGLLVLPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLPLYAAIDNYH
                     GRIENLILSQENQDDQEDWAALKLLILSIESDGLEQAYEEGNISNRAYRVYQRYLKNI
                     EQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKNKEQSRLRALDYDQIAE
                     LYLANTEMIIESLENLKGVYRRSLISFMQESRLRETAIISSGAFVERVINRVKPNNID
                     EMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVR
                     RN"
     gene            15103..15963
                     /locus_tag="ACL8AS_000372"
     CDS             15103..15963
                     /locus_tag="ACL8AS_000372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HGS1228297.1"
                     /translation="MKKWWKELIDKPLLKAFLHYYQASDSELTSVAVAYYWLISIFPL
                     LLVVVNILPYFQIPVGEFLGFMKDVLPPSLYEGVEKIAREVLTQPSTGLLSFSVLSAL
                     WSFSKSMNFLQKAFNKAYGVEKSRGLISHQMLSLLVSFGLQLLFAFALFLILFGQMIL
                     ALLAHYWTKDGIIYQALQGLAGPLIYALLFAILVMLYYFLPNISNRKISYTLPGSAFV
                     LLVILGLLTLFSSYLNYYVHHLVDVRILGSVLLVVMMFWFILIAKIVILGAVINASMQ
                     SLKDPVFKKD"
     gene            16174..16884
                     /gene="ccdA2"
                     /locus_tag="ACL8AS_000373"
     CDS             16174..16884
                     /gene="ccdA2"
                     /locus_tag="ACL8AS_000373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HGS1228298.1"
                     /translation="MGHIFFFLSVFLAGILSFFSPCILPLLPVYTGVLLDDKDGAQAS
                     SGKFSISVTSLLRTLAFIAGISFIFILLGYGAGFLGDLLYASWFQYLTGAIIILLGLH
                     QMEILHFKGLYKEKRLQLQGQGQNGKGYSQAFLLGLTFSFAWTPCVGPVLGSVLALAA
                     SGGSGAWQGAGLMLVYTLGLALPFLLLALTSSYVLKHFRKLHPYLGILKKVGGFLIIV
                     MGLLVLFGNASILSQLFE"
     gene            16904..17470
                     /locus_tag="ACL8AS_000374"
     CDS             16904..17470
                     /locus_tag="ACL8AS_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HGS1228299.1"
                     /translation="MKKWQTCVLGAGSLLCLTACSGKSVTSEHQTKDEMKTEQTASKT
                     SAAKGKEVADFELMGVDGKTYRLSDYKGKKVYLKFWASWCSICLASLPDTDEIAKEAG
                     DDYVVLTVVSPGHKGEQSEADFKNWYKGLDYKNLPVLVDPSGKLLETYGVRSYPTQAF
                     IDKEGKLVKTHPGFMEKDAILQTLKELA"
     gene            17481..18593
                     /gene="msrB"
                     /locus_tag="ACL8AS_000375"
     CDS             17481..18593
                     /gene="msrB"
                     /locus_tag="ACL8AS_000375"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA];
                     GO_process: GO:0006979 - response to oxidative stress
                     [Evidence IEA];
                     GO_process: GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HGS1228300.1"
                     /translation="MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQ
                     GGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYEL
                     INQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
                     DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAY
                     PVIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEP
                     LFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGP
                     QDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD"
     gene            18861..19598
                     /locus_tag="ACL8AS_000376"
     CDS             18861..19598
                     /locus_tag="ACL8AS_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HGS1228301.1"
                     /translation="MTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENGRQAWEL
                     IQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAVKLGVDD
                     YLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLADSQFSL
                     KSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEIAEKVGF
                     EDMNYFTQRFKQIAGVTPRQFKKGEDR"
     gene            19595..21286
                     /locus_tag="ACL8AS_000377"
     CDS             19595..21286
                     /locus_tag="ACL8AS_000377"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HGS1228302.1"
                     /translation="MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGN
                     SQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGIRDLFLTILKSD
                     KDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW
                     VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQH
                     TVYSSSSKMEAMKPYIETGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQL
                     LWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELR
                     EVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFH
                     DSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINEN
                     VAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQD
                     AGDSSQSQLKRGGVGLQNVDQRLKLHFGANYQMKIDSRPQKGTKVEIYINRIETS"
     gene            21402..21965
                     /locus_tag="ACL8AS_000378"
     CDS             21402..21965
                     /locus_tag="ACL8AS_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01440 family protein"
                     /protein_id="HGS1228303.1"
                     /translation="MNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSEVLGGQIG
                     KESSQEIGELIVETILGILGSRGIHLAVQGCEHVNRALVVERQVAEQFDLEIVSVHPT
                     LHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPILREIGHA
                     HVTALASRPKLIGGARAHYPQDAIRKS"
     gene            21987..27599
                     /locus_tag="ACL8AS_000379"
     CDS             21987..27599
                     /locus_tag="ACL8AS_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000472973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ZmpA/ZmpB/ZmpC family metallo-endopeptidase"
                     /protein_id="HGS1228304.1"
                     /translation="MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEII
                     SQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKK
                     IASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLD
                     TVLEETSAKPGEVTVVEVETPQSITNQEQARTENQVVETEEAPKEEAPKTEESSKEEP
                     KSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEES
                     KVEQAGEPVAPREDEKAPVEPEKQPEAPEEEKAVEETPKQEESTPDTKAEETVEPKEE
                     TKTAKGTQEEGKEGQAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEV
                     VERQGSKGVQVTKTTYETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKPVEGTAVETR
                     EEVIPFATKEQEDDTLKRGTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQ
                     APQDEIIKKGTKGLEKPTLEWVKTDKDVLKKSATASYTLNKPDGVEIKSIKVALKDNT
                     GTVIKEVTVEENNLNATLDNLKYYQGYTLSTTMVYNRGEGEETEMLEDKEVQLDLKKV
                     EIKNIKETSLMSVDDAGVETDKSLLTEKPTDVAPLYLRVTTHDNKTTRLAVSSVEEVV
                     VDGKTLYKVVAKAPDLVQRREDDTLSEEYVHYFEKQLPKVDNVYYSFNELITDMQKNP
                     TGTFKLGADLNAANTPTPSKSYVTGEFKGKLSSVDGQHYTIHNTARPLFNNIVGGTVK
                     NINLNNVNIDMPWADQIASVANVIKGGSLIENVKVKGNVLGRNWVSGFIDKIDSGGRL
                     VNVAFIGNVTSVGDGDKFLTGIVGENWKGYVEKAYVEANIKGKRAKAAGISYWSQNSG
                     DNNAVGRDGAIKKSVVKGSIDVEKPIEVGGAVGSLNYLGYIEDTVAMMKVKNGEIFYG
                     SHDIDTDPYYTGERVNRNFIVDGVSEGKSSYTYSKQQKRIKSISQEEADKKIKELGIT
                     ADKFTIIDPIVNKLNNIKQKADTYKDTQDYKVDRELAYRNIEKLQPFYNKEWIVDQGN
                     KVPSNSKLLTTEVLSVTGMKDGQFVTDLSEIDKIMIHYADGTKEEKSVSPKPTSNVEQ
                     VKEYGITDLGDVVYTPNMVVKDRAQLLSDVKAKLDTITLESPEVRAITGNVGALYLEE
                     SFAEVKGNLDKLVKALVENEDHQLNSDEAAIKAFLKKVEDNKAKIMMALTYLNRYYGI
                     EYGDLNIKNIMMFKPDFYGKTPSVIDRLIRIGSQEKNLKGDRTQDAYREIIAGDTGKG
                     DLRSFLDYNMRLFTNDTDLNDWFIHSAKNVYVVEPETTNPDFKNKRHRVFDGLNNNMH
                     ARMILPLLNLKKAHIFMISTYNTMAYSSFEKYGKNTEAEREAFKERINYVAKAQQTYL
                     DFWSRLALPNVRDRLLKSQNMVPTPVWDNQAYAGIKDANRRGYGTDGKVATPIRELFG
                     PTDRWHQINWNMGAMAKVYGKPYEDEQVFFMVTNMLEDFGISAFTHETTHINDRMAYL
                     GGHGHRPGTYLEAYAQGMLQTPDKSTSNGEYGALGINMAYHRQNDGNQWYNPDPDKLQ
                     SREQIDHYMKNYNDALMMLDHLEADAVLPQLNGNTSRWFKKMDRQYRSGNSGHQFDKI
                     RELTEDEKKVAINTIDDLITNNLITKHGAPGDGTYNPTDFRSAYVNMNMMTGIYGGNT
                     STGAPGAASFKHNTFRMWGYFGYENGFVGYASSKYQNAANKENNRMLGDDFIIKKVSN
                     GRFTNLEDWKKEYYKEVKAKGEKGFTAIEIDGKQITNYAELKVLFDKAVEADLAGGGT
                     AKTVELKSKVFKALLKNSDGFTGNLFKA"
     gene            27673..29394
                     /gene="pabB"
                     /locus_tag="ACL8AS_000380"
     CDS             27673..29394
                     /gene="pabB"
                     /locus_tag="ACL8AS_000380"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046820 - 4-amino-4-deoxychorismate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0008153 - para-aminobenzoic acid
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HGS1228305.1"
                     /translation="MHRKTVIDFRALGERHIFTQPIKELKTRDLTEVTALLAQVESYQ
                     EQGYYVVGYVSYEAAPAFEEKLAVHKDPLLGEYLLYFTVHDSVETSPIPLTYEDIDLP
                     SNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLNANPFAIYNRMVVEQEA
                     GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDP
                     KNRSENMMIVDLLRNDMNRISEVGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLV
                     EIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQ
                     LHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFED
                     QHLERLRKASRYFAFPFDAEDLGHKIEEECQDCEANQDYRLRISLSKSGEIEVNRQVL
                     TPLSTSFCQAQVCLQEAALNQSFTYFKTTHRPHLNLGEQEKIYHNKSGELLETSIGNL
                     VLKIAGKLYTPPIRLGILPGIYRQYLLETGQVEEKVLTLADLAQAEAIYGCNAVRGLY
                     ELSLEEN"
     gene            29395..30012
                     /locus_tag="ACL8AS_000381"
     CDS             29395..30012
                     /locus_tag="ACL8AS_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HGS1228306.1"
                     /translation="MKLIFLHGLGQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQA
                     KERVYQHLAQETEPFVLIGLSLGAALALELSSYDLPNLRALILSGCPLKLAGNILFYL
                     QLLIFKLLPKRVFEKQGADKTLMVGVSEELKTLDLTDIAGTCSYPTLLICGSKDKPNL
                     SSMKALHRLLTDSQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK"
     gene            30062..31051
                     /locus_tag="ACL8AS_000382"
     CDS             30062..31051
                     /locus_tag="ACL8AS_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ltp family lipoprotein"
                     /protein_id="HGS1228307.1"
                     /translation="MNKRLFLKMSLVTLPILALFSQPVLAEENIHFSSCKEAWANGYS
                     DIHEGEPGYSAKLDRDHDGVACELKNAPKGAFKAKQSTAIQINTSSATTSGWVKQDGA
                     WYYFDGNGNLVKNAWQGSYYLKADGKMAQSEWIYDSSYQAWYYLTSDGSYAKNAWQGA
                     YYLKSNGKMAQGEWVYDSSYQAWYYLKSDGSYARNAWQGNYYLKSDGKMAKGEWVYVA
                     TYQAWYYLTSDGSYAYSTWQGNYYLKSDGKMAVNEWVDGGRYYVGADGVWKEGQASTA
                     SSSNDSNSEYSAALGKAKSYNSLFHMSKKRMYRQLTSDFDKFSNDAAQYAIDH"
     gene            31186..32145
                     /locus_tag="ACL8AS_000383"
     CDS             31186..32145
                     /locus_tag="ACL8AS_000383"
                     /EC_number="2.7.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002919069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004340 - glucokinase activity [Evidence
                     IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA];
                     GO_process: GO:0051156 - glucose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family glucokinase"
                     /protein_id="HGS1228308.1"
                     /translation="MSQKIIGIDLGGTSIKFAILTTAGEIQGKWSIKTNILDEGSHIV
                     DDMIESIQHRLDLLGLAAADFQGIGMGSPGVVDRDKGTVIGAYNLNWKTLQPIKQKIE
                     KALGIPFFIDNDANVAALGERWMGAGDNQPDVVFMTLGTGVGGGIVAEGKLLHGVAGA
                     AGELGHITVDFDQPISCTCGKKGCLETVASATGIVNLTRRYADEYEGDAALKRLIDNG
                     EEVTAKTVFDLAKEGDDLALIVYRNFSRYLGIACANIGSILNPSTIVIGGGVSAAGEF
                     LLQGVQKVYDENSFPQVRTSTKLALATLGNDAGVIGAASLVLQ"
     gene            32242..33081
                     /locus_tag="ACL8AS_000384"
     CDS             32242..33081
                     /locus_tag="ACL8AS_000384"
                     /EC_number="2.1.1.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate synthase"
                     /protein_id="HGS1228309.1"
                     /translation="MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAF
                     SEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDT
                     GTIGERYGAVVKKHDIINKLFKQLEANPWNRRNIISLWDYQAFEETDGLLPCAFQTMF
                     DVRRIDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNL
                     HIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFD
                     LAI"
     gene            complement(33129..33299)
                     /locus_tag="ACL8AS_000385"
     CDS             complement(33129..33299)
                     /locus_tag="ACL8AS_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3042 family protein"
                     /protein_id="HGS1228310.1"
                     /translation="MAKGFAKGLVTGVAGTVAAVAGAVYAFKKKVIEPEEQKAAFIEE
                     NRKKAARRRVSR"
     gene            33420..34304
                     /gene="miaA"
                     /locus_tag="ACL8AS_000386"
     CDS             33420..34304
                     /gene="miaA"
                     /locus_tag="ACL8AS_000386"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0052381 - tRNA dimethylallyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HGS1228311.1"
                     /translation="MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLD
                     IGTAKASPEEQAAVPHHLIDVREITESYSAFDFVSEAKMTIEDIHSRGKLAIIAGGTG
                     LYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHLVEQAGLEIPQFNRRRAMRA
                     LEIAHFGQDLENQEILYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHS
                     PNVQAAKGIGYKELFPYFRGEQTFEEARESLKQATRRFAKRQLTWFRNRMQVTFYQIG
                     ESGVQDRILSQIEEFLDD"
     gene            34297..35535
                     /gene="hflX"
                     /locus_tag="ACL8AS_000387"
     CDS             34297..35535
                     /gene="hflX"
                     /locus_tag="ACL8AS_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HGS1228312.1"
                     /translation="MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVD
                     SYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVI
                     DRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQ
                     LELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNIL
                     TSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESK
                     HVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYT
                     LISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDG
                     EVITGYISEKNKWRLEEFYD"
     gene            35528..36151
                     /locus_tag="ACL8AS_000388"
     CDS             35528..36151
                     /locus_tag="ACL8AS_000388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine beta-lyase"
                     /protein_id="HGS1228313.1"
                     /translation="MTDIKTLALKYGGYTSLDKVYLDQLLAGKTEQEQLTLITPPPSV
                     VNAYFAELYQKKSPQAATDYFAELSQELNLYNTEPSFTLENKPFIRLNLSGKSFGFCY
                     ESDGLGRIFSENEEKISDDLLFEIAQIFPHQLVFEESGKIYMKPVEDEEVVSLESLTA
                     LTDLERLADGRKRLKGYSQEDLLQEAAAFSGKRYFRSENRTAMLYID"
     gene            36166..37095
                     /gene="rnz"
                     /locus_tag="ACL8AS_000389"
     CDS             36166..37095
                     /gene="rnz"
                     /locus_tag="ACL8AS_000389"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016891 - RNA endonuclease activity,
                     producing 5'-phosphomonoesters [Evidence IEA];
                     GO_process: GO:0042780 - tRNA 3'-end processing [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HGS1228314.1"
                     /translation="MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQN
                     RILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFV
                     LTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
                     GTLDAKKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTR
                     KTDASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHIS
                     ARFLSKDISKLKKDAATIFENVHVVKDLEEVEI"
     gene            37116..37871
                     /locus_tag="ACL8AS_000390"
     CDS             37116..37871
                     /locus_tag="ACL8AS_000390"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HGS1228315.1"
                     /translation="MPTILITGASGGLAQEMVKLLPNDQLILLGRNKEKLAQLYGNYS
                     HAELIEIDITDDSALEALVTDLYLRYGKIDVLINNAGYGIFEGFDQIADKDIHQMFEV
                     NTFALMNLSRHLAARMKESSKGHIINIVSMAGLIATGKSSLYSATKFAAIGFSNALRL
                     ELMPYGVYVTTVNPGPIRTGFFDQADPDGTYLKSVDRFLLEADAVAKKIVKIIGKNKR
                     ELNLPILLNLAHKFYTLFPKLADKLAGETFNYK"
     gene            complement(37925..38833)
                     /locus_tag="ACL8AS_000391"
     CDS             complement(37925..38833)
                     /locus_tag="ACL8AS_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HGS1228316.1"
                     /translation="MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLENEMG
                     IEIFIRNPKGITLTRDGMEFLSYARQVVEQTQLLEERYKNPVAHRELFSVSSQHYAFV
                     VNAFVSLLKKSDMEKYELFLRETRTWEIIDDVKNFRSEVGVLFLNSYNRDVLTKMLDD
                     NHLLAHHLFTAQPHIFVSKTNPLAKKDKVKLSDLENFPYLSYDQGTHNSFYFSEEILS
                     QEHHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDIDDPIELVYI
                     QHEKTSLSKMGERFIDYLLEEVQFDS"
     gene            38897..39166
                     /locus_tag="ACL8AS_000392"
     CDS             38897..39166
                     /locus_tag="ACL8AS_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqgQ family protein"
                     /protein_id="HGS1228317.1"
                     /translation="MSLFLKKTQNFARMSLMKTFYDVQQFLKRFGIIVYMGKRLYDIE
                     LMKLELSRIYDAGLMDKLDYLEAEAVLRREHKVELDYIEKNGEKN"
     gene            39166..39546
                     /locus_tag="ACL8AS_000393"
     CDS             39166..39546
                     /locus_tag="ACL8AS_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HGS1228318.1"
                     /translation="MVTWILWALILAMLAWMGFNYLRIRRAAKIVDNEEFEALIRTGQ
                     LIDLRDPAEFHRKHILGARNIPSSQLKTSLAALRKDKPVLLYENQRAQRVTNAALYLK
                     KQGFSEIYILSYGLDSWKGKVKTS"
     gene            39635..39862
                     /locus_tag="ACL8AS_000394"
     CDS             39635..39862
                     /locus_tag="ACL8AS_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228319.1"
                     /translation="MKEKKKNPLFVGILSIILGLLFPIVGLILGIIGLVLAISYQKES
                     QLDYKIEKILNILGIVISVVNWIVAIALIFR"
     gene            complement(39902..40627)
                     /locus_tag="ACL8AS_000395"
     CDS             complement(39902..40627)
                     /locus_tag="ACL8AS_000395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001235004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_function: GO:0016866 - intramolecular transferase
                     activity [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HGS1228320.1"
                     /translation="MRLDNLLAQEKISRKAMKQALLRGEILVDGCPARSLAQNIDTGL
                     QELLFQDRIIQGYEHTYLMLHKPAGVVTANKDKELPTVMDLLPSDIQSDKLYAVGRLD
                     RDTTGLLLLTDNGPLGFQLLHPQYHVDKTYQVEVNGLLTPDHIQAFQKGIVFLDGTVC
                     KPAKLEILSASPSISQASITISEGKFHQIKKMFLSVGIKVTSLKRIQFGDFTLNPDLA
                     EGNYRPLNQKELQIIKNYLEMSR"
     gene            40789..42630
                     /gene="typA"
                     /locus_tag="ACL8AS_000396"
     CDS             40789..42630
                     /gene="typA"
                     /locus_tag="ACL8AS_000396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003078415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA];
                     GO_process: GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HGS1228321.1"
                     /translation="MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAER
                     AMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVV
                     DAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPVEVVDEVLELFIELGADDDQ
                     LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLD
                     YNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAG
                     DLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSR
                     KVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEV
                     IVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPA
                     RGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMS
                     IEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPR
                     ILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE"
     gene            42650..42904
                     /locus_tag="ACL8AS_000397"
     CDS             42650..42904
                     /locus_tag="ACL8AS_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3165 family protein"
                     /protein_id="HGS1228322.1"
                     /translation="MVYLVLGILLLLLYVFATPESIKGTVNIVAMVCILVALLILLVL
                     SFLKIFQLPTEIFLAIAMLILAYFSVRDITLMPVKKSKRR"
     gene            43267..43566
                     /locus_tag="ACL8AS_000398"
     CDS             43267..43566
                     /locus_tag="ACL8AS_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HGS1228323.1"
                     /translation="MKTKKHRLLALALISSFTLLGAASAAVQYPDGGVWTYGEGSGGG
                     WAFSNYYHGKKYHYSSVVSKWDSHSDKGSAPAGKTSEAWIWTKFGEQVSFYYDYD"
     gene            43637..45658
                     /locus_tag="ACL8AS_000399"
     CDS             43637..45658
                     /locus_tag="ACL8AS_000399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000732428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HGS1228324.1"
                     /translation="MKKLFILLSTFFLSFFFAWIIVLRAPQYLYASYDSVTLLRVKKE
                     AQEPTREVFEQELEKFVNSEQSLIARRIVEPSKDGTTHFTYATYGQGTLPKQFQEASQ
                     ESRERSDPLNSYLLLSGSLTKEKLADKLGDLGYKAIADRKTPPYFLAFRILLNPLILI
                     SLAIFGLSFFALVIITRIKEMRAAGIKLFSGQTLLSIMGHSLSTDIKWLLLSALLSFL
                     GGGVVLFSQGLFYPILLATYGFGISFYLLFLLAISILLMLLYLMSLSYKALVPVIKGR
                     LPLKRLMILTLLCQLVAVFTVGYAVKTGLTSYQRLKELEISKQAWHDRVDYYQISFGL
                     GDRVNDTENQNKWYEFSKEAVEKEQALFVKENLIHFANPQGKNENGETLDTYSPDANV
                     LYVSPSYLDKENVAVNDETRQKLAHLQKGEFGLLLPESLRSQEAELKKVFEERLNYYG
                     KSSEDKDAPLEYEMRAIVSYLPTGQKRFVYNNGESPVSIQYLTDPILVVFTPTSTGDS
                     FISKYVWSINAGKQLFIKGYESGLELLKKAGIYEQVSYLKEGRSVYLTRYNEVQTETA
                     TLILGAIVGIASSLLLFYSVNLLYFEQFRRDILIKRISGLRFFETHAQYMVSQFASFV
                     FGASFFILSSRDLVIGLLTLFVFLASAVLTLYRQAQKESRVSMTIMKGK"
     gene            45660..46301
                     /locus_tag="ACL8AS_000400"
     CDS             45660..46301
                     /locus_tag="ACL8AS_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228325.1"
                     /translation="MIELKNISKKFGSRQLFSDTNLHFEGGKIYALIGTSGCGKTTLL
                     NMIGRLEPYDKGQIIYDGTSLKDIKSSVFFRDYLGYLFQDFGLIESQTVKENLNLGLV
                     GKKLKEKEKISLMKQALNRVNLSYLDLKQPIFELSGGEAQRVALAKIILKDPPLILAD
                     EPTASLDPKNSEELLSILESLKNPNRTIIIATHNPLIWEQVDQVIRVTDLSHR"
     gene            46405..47757
                     /gene="murD"
                     /locus_tag="ACL8AS_000401"
     CDS             46405..47757
                     /gene="murD"
                     /locus_tag="ACL8AS_000401"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008764 -
                     UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
                     [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HGS1228326.1"
                     /translation="MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFE
                     DNPAAQCLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYSNPMIEKALAKGIPVLTE
                     VELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIATD
                     KNTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGLFEEYVAAKWNIQNKMTAAD
                     FLVLNFNQDLVKDLASKTEATVVPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPG
                     SHNVENALATIAVAKLRGVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNI
                     LATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKA
                     GVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
                     "
     gene            47761..48819
                     /locus_tag="ACL8AS_000402"
     CDS             47761..48819
                     /locus_tag="ACL8AS_000402"
                     /EC_number="2.4.1.227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA];
                     GO_function: GO:0051991 -
                     UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-
                     glutamyl-meso-2,
                     6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol
                     4-beta-N-acetylglucosaminlytransferase activity [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0007049 - cell cycle [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0030259 - lipid glycosylation [Evidence
                     IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="HGS1228327.1"
                     /translation="MKKIVFTGGGTVGHVTLNLLLMPKFIEDGWEVHYIGDKRGIEHQ
                     EILKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVCWGIVQSLFIMLRLRPQTLFSKGG
                     FVSVPPVIAARVSGVPVFIHESDLSMGLANKIAYKFATKMYSTFEQASSLSKVEHVGA
                     VTKVSDQKNPEPDELVDIQSHFNHKLPTVLFVGGSAGARVFNQLVTDHKKELTERYNI
                     INLTGDSSLNELSQNLFRVDYVTDLYQPLMELADIVVTRGGANTIFELLAIAKLHVIV
                     PLGREASRGDQLENAAYFVKKGYAEDLQESDLTLDSLEEKLSHLLSHKEDYQAKMKAS
                     KELKSLADFYQLLKKDLS"
     gene            48829..50028
                     /gene="divIB"
                     /locus_tag="ACL8AS_000403"
     CDS             48829..50028
                     /gene="divIB"
                     /locus_tag="ACL8AS_000403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIB"
                     /protein_id="HGS1228328.1"
                     /translation="MSKDKKNEDKEILEELKELSEWQKRNQEYLKKKAEEEAALAEEK
                     EKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVASSEADKEKEEKEEPES
                     KEKEEQDKKLSKKATKEKPAKAKIPGIHILRAFTILFPSLLLLIVSAYLLSPYATMKD
                     IRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVESAQLVYQFPTK
                     FTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFV
                     SELAQISPELKAAIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKP
                     QLSEPSVVDMEAGIYSYTVADKLIMEVEEKAKQEAKEAEKKQEEEQKKQEEESNRNQT
                     TQRSSRR"
     gene            50261..50962
                     /gene="pyrF"
                     /locus_tag="ACL8AS_000404"
     CDS             50261..50962
                     /gene="pyrF"
                     /locus_tag="ACL8AS_000404"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004590 - orotidine-5'-phosphate
                     decarboxylase activity [Evidence IEA];
                     GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0044205 - 'de novo' UMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HGS1228329.1"
                     /translation="MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAG
                     PEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKVLSQLGVDMTNVHAAGGVEMMKAARE
                     GLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEV
                     QVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPV
                     AAYHAIKDEWTQDWN"
     gene            50996..51628
                     /gene="pyrE"
                     /locus_tag="ACL8AS_000405"
     CDS             50996..51628
                     /gene="pyrE"
                     /locus_tag="ACL8AS_000405"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004588 - orotate
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0009220 - pyrimidine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HGS1228330.1"
                     /translation="MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLA
                     YPETRTLIENGFVDAIKEAFPEVEVIAGTATAGIPHGAIIADKMNLPFAYIRSKPKDH
                     GAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
                     KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG"
     gene            51912..52211
                     /locus_tag="ACL8AS_000406"
     CDS             51912..52211
                     /locus_tag="ACL8AS_000406"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228331.1"
                     /translation="MPRWGSDTTSELEKENASAGINNSDSTGGGKRLSTSIRSAYSGS
                     DITPVYSLGSGSRIVMYYNGGGDNYIGSGTRLAMAPQFGNHVRIHTSGSWSPDSY"
     gene            52307..53071
                     /locus_tag="ACL8AS_000407"
     CDS             52307..53071
                     /locus_tag="ACL8AS_000407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228332.1"
                     /translation="MEFFICNLVRVVQSPRFYMSLFLTLLCMSLGNFLAFNGIYKIEG
                     LSIFFAASSIRGFSPISLVAALICTLPYSSQIIEDAESHFLTAQLCRISKKRYLAIVG
                     STAIISSFLVFFLPYLLLLGINLLVTPYQEIYIGAYSGALKELFDSNQLLYSLVTTLW
                     YGVWGAVFSIFGLASALLVKKKIGAIFIPVTYMMVGGIFWAILGLSYLEPVTTLALGY
                     QKDISLSLVSGHLAFILFVSCLVVYGTFFLHSEDYV"
     gene            53071..53823
                     /locus_tag="ACL8AS_000408"
     CDS             53071..53823
                     /locus_tag="ACL8AS_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228333.1"
                     /translation="MKQFVQFYKKDFLAVLVYFILLLSCVLSSTVYLLRCRQYSIHPN
                     VLEWILVLLQDMTTGVYCFPFTYILFFFYLMNNYFNRLECRIRLKSIKHFTSFSFKLA
                     ALSTGIWTAILFLLIFLIAFSNGFSFSLEIKEVDFLREFYGISIANNASFFIGFFFSY
                     IAYYFFLSLLTISSFSWFKKSNMSLVFLFTFLFVESLFWIYQLNNGIIGLLPIFQYMV
                     NSNPYALIYWLTLLSIIIPLTVFSVHRNWRRV"
     gene            53833..54531
                     /locus_tag="ACL8AS_000409"
     CDS             53833..54531
                     /locus_tag="ACL8AS_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228334.1"
                     /translation="MGKLSSHMWRLNQIIYTKYFWGYVLFWILICLGLWYWLEGNDRL
                     VIEILKGPNLSQNSFLVLSIWLLHWFIIHTFFLAVVYRRRASDFFMEVIRFSSIKLWI
                     RYQIWTCFLYGLILIMVKVLVIQFMLQLPNWDIGVLFIVDSLNACVLVLFCFMLYALG
                     ANVQMNFACVSFFLLMIVFGGLFVGNRTNYLFYILNRGNGDIGRDLFLQLLFLVFLFK
                     SIFYFTRQKRRFIE"
     gene            54528..55175
                     /locus_tag="ACL8AS_000410"
     CDS             54528..55175
                     /locus_tag="ACL8AS_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228335.1"
                     /translation="MNEIIILKNIELKLKKTCVFQNLNFSCKQGEIIGITGANGSGKS
                     VLFKLIAGLYSPSYGEVLINGENIVPERKIPANLGALIEEPGFINYYSGFKNLQYLAS
                     IRGVVGNQEINDTLKIVGLYEQKDQKVKTYSLGMRKKLGIAQAIMENPSILLLDEPMN
                     ALDKSSVENMRTLFRKLSSEKGTTILIASHSEEDIRILCDKVYAIEDKVCTLCSD"
     gene            complement(55255..56121)
                     /locus_tag="ACL8AS_000411"
                     /pseudo
     CDS             complement(55255..56121)
                     /locus_tag="ACL8AS_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765255.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine ABC transporter substrate-binding
                     protein"
     gene            complement(56133..56891)
                     /locus_tag="ACL8AS_000412"
                     /pseudo
     CDS             complement(56133..56891)
                     /locus_tag="ACL8AS_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000401.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
     gene            complement(56892..57569)
                     /locus_tag="ACL8AS_000413"
                     /pseudo
     CDS             complement(56892..57569)
                     /locus_tag="ACL8AS_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001154125.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
     gene            complement(57529..58209)
                     /locus_tag="ACL8AS_000414"
     CDS             complement(57529..58209)
                     /locus_tag="ACL8AS_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HGS1228336.1"
                     /translation="MDWSIVEQYLPLYQKAFFLTLHIAVWGILGSFLLGLIVSIIRHY
                     RIPVLAQVATAYIELSRNTPLLIQLFFLYFGLPRIGIVLSSEVCATLGLVFLGGSYMA
                     ESFRSGLEAISQTQQEIGLAIGLTPLQVFRYVVLPQATAVALPSFSANVIFLIKETSV
                     FSAVALADLMYVAKDLIGLYYETDIALAMLVVAYLIMLLPISLVFSWIERRTRHAGFG
                     NPSTLSRK"
     gene            58424..58555
                     /locus_tag="ACL8AS_000415"
                     /pseudo
     CDS             58424..58555
                     /locus_tag="ACL8AS_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lactate oxidase"
     gene            58698..60188
                     /gene="lysS"
                     /locus_tag="ACL8AS_000416"
     CDS             58698..60188
                     /gene="lysS"
                     /locus_tag="ACL8AS_000416"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004824 - lysine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006430 - lysyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HGS1228337.1"
                     /translation="MSTEHMEELNDQQIVRREKMAALREQGIDPFGKRFERTANSQEL
                     KDKYANLDKEQLHDKNETATIAGRLVTKRGKGKVGFAHLQDREGQIQIYVRKDAVGEE
                     NYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
                     YRKRYLDLISNRESFERFVTRSKIISEIRRYLDQKGFLEVETPVLHNEAGGAAARPFI
                     THHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQ
                     AYADFQDIMDLTEGIIQHAAKSVKGDGPVNYQGTEIKINEPFKRVHMVDAIREITGVD
                     FWQDMTLEEAKAIAAEKKVPVEKHYTEVGHIINAFFEEFVEETLIQPTFVYGHPVAVS
                     PLAKKNPEDQRFTDRFELFIMTKEYGNAFTELNDPIDQLSRFEAQAKAKELGDDEATG
                     IDYDYIEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK"
     gene            60812..61948
                     /gene="lctO"
                     /locus_tag="ACL8AS_000417"
     CDS             60812..61948
                     /gene="lctO"
                     /locus_tag="ACL8AS_000417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate oxidase"
                     /protein_id="HGS1228338.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTF
                     TLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVA
                     TARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKDEG
                     YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSP
                     RDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQE
                     VAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEH
                     LNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY"
     regulatory      62202..62290
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            62505..63173
                     /locus_tag="ACL8AS_000418"
     CDS             62505..63173
                     /locus_tag="ACL8AS_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TenA family protein"
                     /protein_id="HGS1228339.1"
                     /translation="METQDYAFQPGLTVGELLKSSQKDWQAAINHRFVKELFAGTIEN
                     KVLKDYLIQDYHFFDAFLSMLGACVAHADKLESKLRFAKQLGFLEADEDGYFQKAFKE
                     LKVAENDYLEVTLHPVTKAFQDLMYSAVASSDYAHLLVMLVIAEGLYLDWGSKDLALP
                     EVYIHSEWINLHRGPFFAEWVQFLVDELNRVGKNREDLTELQQRWNQAVALELAFFDI
                     GYDV"
     gene            complement(63170..63397)
                     /locus_tag="ACL8AS_000419"
     CDS             complement(63170..63397)
                     /locus_tag="ACL8AS_000419"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228340.1"
                     /translation="MKIKEQTRKLTADCSKHCFEPVDKTDEVSSKHCFEVVDRTDEVS
                     NHTYGKVKLTWFEEIFEEYYLIKFVNIMSLL"
     gene            63500..64282
                     /gene="thiM"
                     /locus_tag="ACL8AS_000420"
     CDS             63500..64282
                     /gene="thiM"
                     /locus_tag="ACL8AS_000420"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HGS1228341.1"
                     /translation="MTSLKLLKKKAPLVICITNDVVKNFTANGLVALGASPAMSEFPA
                     DLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKKVA
                     DDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVT
                     GEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVVASFIGLEKGQELKSLETAMLVY
                     NIAGEMAEKRPNGHLPGTFKVEFINALYEITDEDVKEFKRVK"
     gene            64284..64913
                     /gene="thiE"
                     /locus_tag="ACL8AS_000421"
     CDS             64284..64913
                     /gene="thiE"
                     /locus_tag="ACL8AS_000421"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000468574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HGS1228342.1"
                     /translation="MFHKELLKLYFICGTTTCQGKNLYTVVEEALKGGITLFQFREKG
                     EGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRK
                     LMPDKIIGLSIRNEEEFQQSKVEYVDYVGVGPVFDTQSKDDAGGAIGYEGLELMRKLL
                     PQMPLVAIGGIQTKHIKDIIKTNMDGVSIISAISYAKNIEKTVREMSEQ"
     regulatory      65122..65210
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            65472..66032
                     /locus_tag="ACL8AS_000422"
     CDS             65472..66032
                     /locus_tag="ACL8AS_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HGS1228343.1"
                     /translation="MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQ
                     AFANEILFGLWCMAAPIAAIFVPRVGSATIGEVLAALAEVLYGSQFGLGALLSGLVQG
                     LGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRFI
                     SVYFFCTILVRAIVKLYHQFATGGKA"
     gene            66033..67418
                     /locus_tag="ACL8AS_000423"
     CDS             66033..67418
                     /locus_tag="ACL8AS_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1228344.1"
                     /translation="MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQMI
                     AQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILLQNLNHQFTMENLFEELIFTLENI
                     GYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
                     ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPS
                     YEMTQVASKEVASSPELFHMDRTTCEFGNRSLFSIADFTFYQGISCILGDNGVGKSTL
                     FRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDS
                     ERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDD
                     RACHYFCKWIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLT
                     SQSSNTQGEVR"
     gene            67420..68070
                     /locus_tag="ACL8AS_000424"
     CDS             67420..68070
                     /locus_tag="ACL8AS_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /protein_id="HGS1228345.1"
                     /translation="MVKVATQTPIISLFLLILSLETSFIPSIALNLSVVAFCILFMLY
                     YRRFKMLAWMIILAILPSFANYWAVQLHGDASQAVMLGTRAFVTVCIGLVFVSSISLK
                     ELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKV
                     LMTVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFL"
     gene            68081..68773
                     /gene="tenA"
                     /locus_tag="ACL8AS_000425"
     CDS             68081..68773
                     /gene="tenA"
                     /locus_tag="ACL8AS_000425"
                     /EC_number="3.5.99.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050334 - thiaminase activity [Evidence
                     IEA];
                     GO_process: GO:0006772 - thiamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiaminase II"
                     /protein_id="HGS1228346.1"
                     /translation="MEFTDIAMELSKKAWQASFHHPFILQLQEGNLEPAIFRYYLIQD
                     AYYLKAFSEIYHLLADKTSNQEMKRLLKQNAQGLVEGELFIRQQFFKELEISDQEMEQ
                     HPIAPTCYHYISHIYRQFAEPNLAIAFASLLPCPWLYHDIGKSLNLKPSPNPLYQQWI
                     ETYITDELEQQIREEGALVNQLYRESDETDKQKMLDAFHISVHMEAKFWEMAYQHQTW
                     KSDLQSLEKGEE"
     gene            68778..69302
                     /gene="thiW"
                     /locus_tag="ACL8AS_000426"
     CDS             68778..69302
                     /gene="thiW"
                     /locus_tag="ACL8AS_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001225563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005215 - transporter activity [Evidence
                     IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy coupling factor transporter S component
                     ThiW"
                     /protein_id="HGS1228347.1"
                     /translation="MRKHQLQVHKLTILSMMTALDVVLTPIFRIEGMAPMSSVVNILA
                     GIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAGLFYKYGRKFYFSALGE
                     IVGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEF
                     FKKVQGYFFSERID"
     gene            69302..70105
                     /locus_tag="ACL8AS_000427"
     CDS             69302..70105
                     /locus_tag="ACL8AS_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HGS1228348.1"
                     /translation="MQEFTNPFPIGSSSLIHCMTNEISCEMLANGILALGCKPVMADD
                     PREVLDFTKQSQALFINLGHLSAEKEKAIRIAASYAAQVCLPMVVDAVGVTASSIRKS
                     LVRDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYHG
                     MSFLVTGPKDLVVSKNQVAVLGNGCAELDWITGTGDLVGALTAVFLSQGKTGFEASCL
                     AVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE"
     gene            70098..70730
                     /gene="thiE"
                     /locus_tag="ACL8AS_000428"
     CDS             70098..70730
                     /gene="thiE"
                     /locus_tag="ACL8AS_000428"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HGS1228349.1"
                     /translation="MNREALRLYLVTNRYQDSVESFLAKVETACRSGVTIVQLREKNL
                     TTNQYYQLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARKVLGP
                     EKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLKTICQTVAIPV
                     VAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQAFLTKLHDILS"
     gene            complement(70939..71730)
                     /gene="thiD"
                     /locus_tag="ACL8AS_000429"
     CDS             complement(70939..71730)
                     /gene="thiD"
                     /locus_tag="ACL8AS_000429"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HGS1228350.1"
                     /translation="MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVA
                     QNTRGVQLIEHVSPQMLKAQLESVFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDCPY
                     VLDPVMVATSGDALIGSNARDYLKTNLLPLATIITPNLPEAEEIVGFSIHDPEDMQRA
                     GRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESPRIQTCHTHGTGCTFAAVI
                     TAELAKGKSLYQAVDKAKAFITKAIQDAPQLGHGSGPVNHTTFKD"
     regulatory      complement(71814..71912)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            72096..72491
                     /locus_tag="ACL8AS_000430"
     CDS             72096..72491
                     /locus_tag="ACL8AS_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0006825 - copper ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CopY/TcrY family copper transport repressor"
                     /protein_id="HGS1228351.1"
                     /translation="MQISDAEWQVMKIIWMQGEQTSTDLIRVLAERFDWSKSTVQTLL
                     ARLVEKECLTRKKEGKSFVYSALLTLDQSRDLLVQDIKDKVCSRRIRNLLADLIVECE
                     FTQTDLEDLEAVISEKKSSAVTEVRCNCM"
     gene            72502..72873
                     /locus_tag="ACL8AS_000431"
     CDS             72502..72873
                     /locus_tag="ACL8AS_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupredoxin domain-containing protein"
                     /protein_id="HGS1228352.1"
                     /translation="MLNSIVTIICIALIAFILFWFFKKPEKSGQKAQQKNGYQEIRVE
                     VMGGYTPELIVLKKSVPARIVFDRKDPSPCLDQIVFPDFGVHANLPMGEEYVVEITPE
                     QAGEFGFACGMNMMHGKMIVE"
     gene            72883..75126
                     /locus_tag="ACL8AS_000432"
     CDS             72883..75126
                     /locus_tag="ACL8AS_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042625 - ATPase-coupled ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HGS1228353.1"
                     /translation="MTEIVKASLENGIQKIRIRAEKGYHPAHIQLQKGIPAEITFHRA
                     TPSNCYKEILFEEEGILEPIGVDEEKVIRFTPQELGRHEFSCGMKMQKGSYTVVEKTR
                     KSLSLLQRFWITSIFTVPLVILMIGMLTGSISHQVMHWGTFLATTPIMLVAGKPYIQS
                     AWASFKKHNANMDTLVALGTLVAYFYSLVALFAGLPVYFESAGFILFFVLLGAVFEEK
                     MRKNTSQAVEKLLDLQAKTAEVLSDDSYVQVPLEQVKVGDLIRVRPGEKIAVDGVVVE
                     GVSSIDESMVTGESLPVDKTVGDTVIGSTINHSGTLVFRAEKVGSETVLAQIVDFVKK
                     AQTSRAPIQDLTDKISGIFVPVVVILGIMTFWVWFVLLRDSVVVLGASFVSSLLYGVA
                     VLIIACPCALGLATPTALMVGTGRSAKMGVLLKNGTVLQEIQKVQTLVFDKTGTLTEG
                     KPVVTDVIGDEVEVFRLAASLEDASQHPLAEAIVKRASEAGLEFQTVENFQTLHGKGV
                     SGRINGKQVLLGNAKMLDGMDISNTYQDKLEELEKEAKTVVFLAVDNEIKGLLALQDI
                     PKENAKLAISQLKKRGLRTVMLTGDNAGVARAIADQIGIEEVIAGVLPEEKAHEIHKL
                     QQSGKVAFVGDGINDAPALSVADVGIAMGAGTDIAIESADLVLTTNNLLGVVRAFDMS
                     KKTFHRILLNLFWAFIYNVVGIPIAAGVFSGVGLALNPELAGLAMAFSSVSVLTSSLL
                     LNFSKID"
     gene            75333..77108
                     /gene="spxB"
                     /locus_tag="ACL8AS_000433"
     CDS             75333..77108
                     /gene="spxB"
                     /locus_tag="ACL8AS_000433"
                     /EC_number="1.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047112 - pyruvate oxidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate oxidase"
                     /protein_id="HGS1228354.1"
                     /translation="MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKD
                     IRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAIL
                     GSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAISKKGPAVV
                     EIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGV
                     KAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLF
                     LGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPV
                     ESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTT
                     QTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPD
                     VITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFT
                     VDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKE
                     KYEAEELVPFRLFLEEEGLQSRAIK"
BASE COUNT        23483 a        14086 c        16987 g        22626 t
ORIGIN      
        1 agcggataat caagaacaac tctttgatca ggttgcaact ttattggaag aacgagaaat
       61 tgtcactcca acttatcgtg aagccttgat cacgcgtgaa aagtcatttc caactggttt
      121 agatatggaa tttctaggaa aggacttgcc aaatgtagcg attcctcata cagatattgt
      181 tcataatcta gctgagaaag tggtggttgt tcgattagaa aaaccagtaa cttttcacaa
      241 tatgatagct cctgataagg aagtagaagt atccctactc ttctttatta ttaacaattc
      301 aagttcaagt caaacaaata ttctggctca gttgatggac tttttcacag gaaatggaca
      361 tcttgaagat ttatcaaaaa tttccgaacc agaaaaactt tatgcttaca ttgctgaagc
      421 aaccgcttaa tcttgtctat taaaaaataa aatcggagga aatccaaatg attaaaattc
      481 ttgctgcctg cggtgcaggt gttaactcaa gtcaccaaat taaaagtgct ctagaagaag
      541 aactttcaaa ccgtggttat gatgttcact gtgatgcagt catggtgaaa gatgtaaacg
      601 aagaccttat gaaaggttac gatatcttta caccaatcgc tgcaacagac cttggttttg
      661 aaccaggtat cccagttatc gaagctgggc caatcttatt ccgtatccca gcaatgagtg
      721 ctccagtatt tgacaatatt gaatcagcta ttaaagaaca cgaattaagc taattctaat
      781 ttgttaacat tcatataaca taaaaaaggg aggaactgtt atggatgcaa tctttgacct
      841 aatcggaaag gttttcaatc ccatcttaga aatgggtgga cctgtcatca tgttaatcat
      901 tttgacagta ttggctttac tttttggagt gaaattctcc aaagcgcttg aaggtggtat
      961 caaacttgcc atcgctctta caggtatcgg tgctatcatc ggtatgctaa atggtgcttt
     1021 ctcagcatca cttgcaaaat tcgttgaaaa cactggtatc caattgagta ttaccgacgt
     1081 tggttgggca ccactcgcaa caatcacttg gggttctgct tggacactat acttcttgct
     1141 catcatgttg attgtcaacg tagtgatgct tgctatgaag aaaaccgata cacttgatgt
     1201 cgatatcttt gatatctggc acttgtctat cacaggtctc ttgattaaat ggtatgctga
     1261 taacaatggt gtgagtcaag gggtttcact ctttattgct acagcagcta tcgtccttgt
     1321 cggtgtgttg aaaattatca actctgactt gatgaaacct acatttgatg accttcttaa
     1381 cgccccaagt tcatcaccaa tgacatcaac tcacatgaac tacatgatga acccagttat
     1441 catggttttg gataagattt ttgaaaaatt cttcccaggc cttgataaat atgactttga
     1501 tgctgctaaa ttgaacaaga aaatcggttt ctggggatct aaattcttca tcggtttcat
     1561 ccttggtatc gttatcggta ttatgggaac tccacatcca attgcaggtg ttgcagatgc
     1621 agataaatgg cgtcttgtta tcaaaggatg gttgtctctt ggtttgactg ccggtgtatc
     1681 tttggaactc ttctcactta tcggttcatg gttcatcgca gccgtagaac cactatcaca
     1741 aggtattaca aacgttgcta ctaaacgtct tcaaggacgt aaattcaata tcggtcttga
     1801 ctggccattc atcgctggtc gtgctgaaat ctgggcttgt gccaacgtac ttgcaccaat
     1861 catgttgatt gaagcagtgc ttctttcaaa agttggaaat ggtatcttgc cacttgcagg
     1921 tatcatcgct atgggtgtta ctccagctct cttggttgta actcgtggta aattgctccg
     1981 tatgattatc ttcggaacac tcttgttgcc actcttcctt ctttcaggta cccttattgc
     2041 accatttgca acagaacttg ctaaaggtgt aggtgccttc ccagaaggtg tgagccaaac
     2101 tcaattgatt actcactcta ctcttgaagg accaatcgaa aaacttcttg gttggacaat
     2161 tggtaacact acaactggtg atatcaaagc aatccttggt gcagtagtct tccttgtatt
     2221 ctatatcggt atctttgctt ggtacagaaa acaaatgatc aaacgtaacg aagagtacgc
     2281 agcaaaagca aaataatgcg ctcctataaa atataaactc aatgaaaatc aaagagcaaa
     2341 ctaggaagct agccgcaggt tgctcaaaac acagttttga ggttgtagat aagactgacg
     2401 aagtcagctc aaaacacagt tttgaggttg tagatgaaac tgacgaagtc agctcaaaac
     2461 atggttttga ggttgtagat gaaactgacg aagtcagtaa tcatatctat ggcaaggcga
     2521 cactgacgaa gtttgaattg gattttcgca gagtgtaaat tgttgaaact aggttgtcat
     2581 accatgtata ccacttgggt tttggcagta gctaactgca ctaaatataa tataaggagg
     2641 gttttatggg gaaaggtcat tggaatcgga aaagagttta tagcattcgt aagtttgctg
     2701 tgggagcttg ctcagtaatg attgggactt gtgcagttct attaggagga aatatagctg
     2761 gagaatctgt agtttatgcg gatgaaacac ttattactca tactgctgag aaacctaaag
     2821 aggaaaaaat gatagtagaa gaaaaggctg ataaagcttt ggaaactaaa aatgtagttg
     2881 aaaggacaga acaaagtgaa cctagttcaa ctgaggctat tgcatctgag aagaaagaag
     2941 atgaagccgt aactcaaaaa gaggaaaaag tgtctgctaa accggaagaa aaagctccaa
     3001 ggatagaatc acaagcttca agtcaagaaa aaccgctcaa ggaagatgct aaagctgtaa
     3061 caaatgaaga agtgaatcaa atgattgaag acaggaaagt ggattttaat caaaattggt
     3121 actttaaact caatgcaaat tctaaggaag ccattaaacc tgatgcagac gtatctacgt
     3181 ggaaaaaatt agatttaccg tatgactgga gtatctttaa cgatttcgat catgaatctc
     3241 ctgcacaaaa tgaaggtgga cagctcaacg gtggggaagc ttggtatcgc aagactttca
     3301 aactagatga aaaagacctc aagaaaaatg ttcgccttac ttttgatggt gtctacatgg
     3361 attctcaagt ttatgtcaat ggtcagttag tggggcatta tccaaatggt tataaccagt
     3421 tctcatacga tatcaccaaa taccttcaca aagatggtcg tgagaatgtg attgctgtcc
     3481 atgcagtcaa caaacagcca agtagccgtt ggtattcagg aagtggtatc tatcgtgatg
     3541 tgactttaca agtgacagat aaggtgcatg ttgagaaaaa tgggacaact attttaacac
     3601 caaaacttga agaacaacaa catggcaagg ttgaaactca tgtgaccagc aaaatcgtca
     3661 atacggacga caaagaccat gaacttgtag ccgaatatca aatcgttgaa cgaggtggtc
     3721 atgctgtaac aggcttagtt cgtacagcga gtcgtacctt aaaagcacat gaatcaacaa
     3781 gcctagatgc gattttagaa gttgaaagac caaaactctg gaccgtttta aatgacaaac
     3841 ctgccttgta cgaattgatt acgcgtgttt accgtgacgg tcaattggtt gatgctaaga
     3901 aggatttgtt tggttaccgt tactatcact ggactccaaa tgaaggtttc tctttgaatg
     3961 gtgaacgtat taaattccat ggagtatcct tgcaccacga ccatggggcg cttggagcag
     4021 aagaaaatta taaagcagaa taccgtcgtc tcaaacaaat gaaggagatg ggagttaact
     4081 ccatccgtac aacccacaac cctgctagtg agcaaacctt gcaaatcgca gcagaactag
     4141 gtttactcgt tcaggaagag gcctttgata cttggtatgg tggcaagaaa ccttatgact
     4201 atggacgttt ctttgaaaaa gatgccactc acccagaagc tcgaaaaggt gaaaaatggt
     4261 ctgattttga cctacgtacc atggtcgaaa gaggcaaaaa caaccctgct atcttcatgt
     4321 ggtcaattgg taatgaaata ggtgaagcta atggtgatgc ccactcttta gcaactgtta
     4381 aacgtttggt caaggttatc aaggatgttg ataagactcg ctatgttacc atgggagcag
     4441 ataaattccg tttcggtaat ggtagcggag ggcatgagaa aattgctgat gaactcgatg
     4501 ctgttggatt taactattct gaagataatt acaaagccct tagagctaag catccaaaat
     4561 ggttgattta cggttcagaa acatcatcag caacccgtac acgaggaagt tactatcgcc
     4621 ctgaacgtga attgaaacat agcaatggac ctgagcgtaa ttatgaacag tctgactatg
     4681 ggaatgatcg tgtgggttgg gggaaaacag caaccgcttc atggactttt gaccgtgaca
     4741 acgctggcta tgctggacag tttatctgga caggtacgga ctatattggt gaacctacac
     4801 catggcacaa ccaaaatcaa actcctgtta agagctctta ctttggtatc gtagatacag
     4861 ccggcattcc aaaacatgac ttctatctct accaaagcca atgggtttct gttaagaaga
     4921 aaccgatggt acaccttctt cctcactgga actgggaaaa caaagaatta gcatccaaag
     4981 tagctgactc agaaggtaag attccagttc gtgcttattc gaatgcttct agtgtagaat
     5041 tattcttgaa tggaaaatct cttggtctta agactttcaa taaaaaacaa accagcgatg
     5101 ggcggactta ccaagaaggt gcaaatgcta atgaacttta tcttgaatgg aaagttgcct
     5161 atcaaccggg taccttggaa gcaattgctc gtgatgaatc tggcaaggaa attgctcgag
     5221 ataagattac gactgctggt aagccagcgg cagttcgtct tattaaggaa gaccatgcga
     5281 ttgcagcaga tggaaaagac ttgacttaca tctactatga aattgttgac agccagggga
     5341 atgtggttcc aactgctaat aatctggttc gcttccaatt gcatggccaa ggtcaactgg
     5401 tcggtgtaga taacggagaa caagccagcc gtgaacgcta taaggcgcaa gcagatggtt
     5461 cttggattcg taaagcattt aatggtaaag gtgttgccat tgtcaaatca actgaacaag
     5521 cagggaaatt caccctgact gcccactctg atctcttgaa atcgaaccaa gtcactgtct
     5581 ttactggtaa aaaagaagga caagagaaga ctgttttggg gacagaagta gcaagagttc
     5641 gtacattaat tggtaaagaa ccaaaaatgc cgaaaacagt aggttttgta tacagcgatg
     5701 gtagtcgtga aaaacttcca gtaacttggt ctcaagtcga tgttagtcaa gcaggagttg
     5761 tgactgttaa aggtacagca aatggacgtg aggtagaggc tcatgtcgag gttctagcaa
     5821 ttgcgaaaga attaccaaca gttaaacgta ttgctccaaa tactgacttg aattctgtag
     5881 acaaatctgt ttcttatgtt ttgactgatg gaagtgtaca agagtacgaa gtagatagct
     5941 gggagattac ggaagtagat aaagccaaac tttcagtagc tggatcacgt attcaaatga
     6001 ctggtcagtt agctggagaa actattcatg caacccttgt ggtagaagaa ggaaatgctg
     6061 cagcacctgt agtgccaact gttactgttg gaggtgaagc agtaacaggt cttactagtc
     6121 gacaaccaat gcaatatcgt actctatctt atggtgccca attgccagaa gtcacagcaa
     6181 gtgctgaaaa tgctgatgtg acagttcttc aagcaagcgc agcaaacggc atgcgtgcaa
     6241 gcatatttgt tcagcctaaa gatggtggcc ctcttcaaac ctatgcaatt caattcctag
     6301 aagaagcacc aaaaattgct cacttgagct tgcaagtgga aaaagctgac agtctcaaag
     6361 aagaccaaac tgtcaaattg tcggttcgag ctcactatca agatggaacg caagctgtat
     6421 taccagctga taaagtaacc ttctctacaa gtggtgaagg ggaagtcgca attcgtaaag
     6481 gaatgcttga gttgcataag ccaggagcag tcactctgaa cgctgaatat gagggagcta
     6541 aaggccaagt tgaactcact atccaagcca atactgagaa gaagattgcg caatccatcc
     6601 gtcctgtaaa tgtagtgaca gatttgcatc aggaaccaag tcttccagca acagtaacag
     6661 ttgagtatga caaaggtttc cctaaaactc ataaagtcac ttggcaagct attccgaaag
     6721 aaaaactaga ctcctatcaa acatttgaag tactaggtaa agttgaagga attgaccttg
     6781 aagcgcgtgc aaaagtctct gtagaaggta tcgtttcagt tgaagaagtc agtgtgacaa
     6841 ctccaatcgc agaagcacca caattaccag aaagcgttcg gacatatgat tcaaatggtc
     6901 acgtttcatc agctaaggtt gcatgggatg cgattcgtcc agagcaatac gctaaggaag
     6961 gtgtctttac agttaatggt cgcttagaag gtacgcaatt aacaactaaa cttcatgttc
     7021 gcgtatctgc tcaaactgag caaggtgcaa acatttctga ccaatggacc ggttcagaat
     7081 tgccacttgc ctttgcttca gattcaaatc caagcgaccc agtttcaaat gttaatgaca
     7141 agctcatttc ctacaataac caaccagcca atcgttggac aaactggaat cgtagtaatc
     7201 cagaagcttc agtcggtgtt ctgtttggag attcaggtat cttgagcaaa cgctccgttg
     7261 ataatctaag tgtcggattc cacgaagacc atggagttgg tgcaccgaag tcttatgtga
     7321 ttgagtatta tgttggtaag actgtcccaa cagctcctaa aaaccctagt tttgttggta
     7381 atgaggacca tgtctttaat gattctgcca actggaaacc agttactaat ctaaaagccc
     7441 ctgctcaact caaggctgga gaaatgaacc actttagctt tgataaagtt gaaacctatg
     7501 ctattcgtat tcgcatggtt aaagcagata acaagcgtgg aacgtctatc acagaggtac
     7561 aaatctttgc gaaacaagtt gcggcagcca aacaaggaca aacaagaatc caagttgacg
     7621 gcaaagactt agcaaacttc aaccctgatt tgacagacta ctaccttgag tctgcagatg
     7681 gaaaagttcc ggcagtcaca gcaagtgtta gcaacaatgg tctcgctacc gtcgttccaa
     7741 gcgttcgtga aggtgagcca gttcgtgtca tcgcgaaagc tgaaaatggc gacatcttag
     7801 gagaataccg tctgcacttc actaaggata agaacttact ttctcataaa ccagttgctg
     7861 cggttaaaca agctcgcttg ctacaagtag gtcaagcact tgaattgccg actaaggttc
     7921 cagtttactt cacaggtaaa gacggctacg aaacaaaaga tttgtcagtt gaatgggaag
     7981 aagttccagc agaaaatctg acaaaagcag gtcaatttac cgttcgaggc catgtccttg
     8041 gtagtgatct tgttgctgag gtcactgtac gagtgacaga caaactaggc gaagctcttt
     8101 cagataaccc taactatgat gaaaacagta accaggcctt tgcttcagca accaatgata
     8161 ttgacaaaaa ctctcatgac cgcgttgact atctcaatga cggagatcat tcagaaaatc
     8221 gtcgttggac aaactggtct ccaacaccat cttctaatcc agaagtatca gcgggtgtga
     8281 tcttccgtga aaatggtaag attgtagaac ggactgttgc gcaagccaaa cttcgtttct
     8341 ttgcagatag tggtacggat gcaccaacta aactcgtttt agaacgctat gtcggtccag
     8401 agtttgaagt gccaacctac tattcaaact accaagccta cgacgcagac catccattca
     8461 acaatccaga aaattgggaa gctgtgcctt atcgtgcgga taaagacatc gcagctggtg
     8521 atgaaatcaa cgtaacattt aaagctgtca aagccaaagc tatgagatgg cgtatggagc
     8581 gtaaagctga caagagcggt gttgcgatga ttgagatgac cttccttgca ccgagtgaat
     8641 tgcctcaaga aagtacgcaa tcgaagattc ttgtagatgg aaaagaactt gctgatttcg
     8701 ctgaaaatcg tcaagactat caaattacct ataaaggtca acggccaaaa gtctcagttg
     8761 aagaaaacaa tcaagtagct tcaactgtgg tagatagtgg agaagatagc cttccagtac
     8821 ttgttcgcct cgtttcagaa agtggaaaac aagtcaagga ataccgtatc cacttgacta
     8881 aggaaaaacc agtttctgag aagacagttg ctgctgtaca agaagatctt ccaaaactcg
     8941 aatttgttga aaaagatttg gcctacaaga cagttgagaa aaaagattca acactgtatc
     9001 taggtgaaac tcgtgtagaa caagaaggaa aaactggtaa agaacgtatc tttacagcga
     9061 ttaatcctga tggaagtaag gaagaaaaac tccgtgaagt ggtagaagct ccgacagacc
     9121 gcatcgtctt ggttggaacc aaaccagtag ctcaagaagc taaaaaacca caagtgtcag
     9181 aaaaagcaga tacaaaacca attgattcaa gtgaagctag tcaaactaat aaagcccagt
     9241 taccaaatac aggtagtgcg gcaagccaag cagcagtagc agcaggttta gctcttctag
     9301 gtttgagtgc aggattagta gttactaaag gtaaaaaaga agactagaaa ttttgatacc
     9361 ttctttatca ttaaagacca aagaaaaact cttgtcctaa atagaagata aagagtctgg
     9421 aacaaaatag ttctcaacca caaaaaagct agatatttcc aattgcggaa ctctagcttt
     9481 ttaattttga gtcgttctct tattgtatag tagattgaaa ctagagtagt acacttctac
     9541 ttctaaaaca ttgttagaaa tcgatttgac tgtccttatc gatttgtcct gttcttattt
     9601 catttaacta tattttagga ggttattggc cataagtacc aatcccatgt caattctcac
     9661 ttgacgcttg cccctcagat tacatctctt gtaacccaaa caagccttta actgcccaaa
     9721 gacaggttcc acatcaatct tgcgttgagc gaaaatctgt ctaccttggg gagataaaag
     9781 cgcctgacat tctttagctt tcaagttttg atagcgttcg ttcatatata gccccctttt
     9841 gaggggctga ttcaggttca tcagcgtagt aaaccttgat ttcctgttga aagtctgtct
     9901 gtgttttctg atgtttggta tggtgaaaac gataatacca gccatcagga tgtgtgtagc
     9961 tatcctcctt gtcattatag tgccaattcg ctaagttttt agctgactgt ttataccctc
    10021 tcttttgttc cttatcaaac atggcatatt taatcagaag gggagtgatt tcttcttgaa
    10081 aatagacttg tatctgttct tgaagtttgg cggagaattt ctctgtcgtt ttcttccaca
    10141 caaaactata cttgttggca ttggcttcaa tcttagttcc gtcaataaac aaacaatcta
    10201 aggtcactaa ctcttccatt tttcaatttt tcgaccagag aaaatccctt gtgaataggc
    10261 aaatagaaga gtagatacaa gcattttaag gtgataagac gggcgatcaa aggcatgata
    10321 gaaggcgtgg aaatgacaat cctccaaggt attcaccact ttttcaatag taaaaacgag
    10381 atggtcttgt ggcaagaagg aactgatttt tagtggtaaa gttgtttgat ttgtgttata
    10441 gtgaatatgc atgggatagc ctttctaaat ggtttattgt gcaattctat tttaccaaga
    10501 ctatcgcaac catgcaaaaa agcaacggca aatccgttgc tttttttgga gataagagac
    10561 tattgtccca gactcttttc tttgtataaa attgtatagt gttattgtct atactatttt
    10621 gtagagaaag caaaaatccc tagaaaatgc ttagggattc gactatttca ttaagaacaa
    10681 ttcaacaatc atttctacat acatgataag ggttaataag aatcctgcac gccagaagaa
    10741 tttgatgaat ttaggatagt aaaagctgcg ttttttcaaa aggaagaaaa agacgagaat
    10801 aatggctagg atcgagaggg ttagccccag tctagggagg aaattatggg taaaggtttt
    10861 agctgtaatc aggtaatatt caaataccaa gaccggaaaa gccaaatccg caaagtttcg
    10921 tcctagtttt tttaatctaa aaagtttggt taggataatg cagacgacta aggtcagtat
    10981 caataataaa atagatgcta atttcattaa aatcataccc atattgtatc ataaaaaaag
    11041 gctaatggaa acgagaaaca gaggaattta taggaaagtc aggcttttga gattgtgggt
    11101 gatttttgtt ataatgaaag ttataaaatc ttataatacc ttgaatgatt attatcgaaa
    11161 actctttgga gaaaagactt ttaaagtccc tattgatgcg ggatttgact gtcccaatcg
    11221 tgatggaact gtggctcatg gaggctgtac tttttgtacg gtttcaggtt ctggagatac
    11281 tattgtagcc ccagatgcgc ctatccgtga gcaattttat aaggaaattg actttatgca
    11341 ccgtaagtgg ccggatgttc agaagtatct ggtttatttt caaaatttta ccaacaccca
    11401 tgaaaaggtg gaagttattc gagagcgtta tgaacaggct atcaatgagc caggtgtggt
    11461 aggaatcaat attggaatgc gcccagactg tttaccagac gaaaccatcg aatatttggc
    11521 tgagttatcg gagtgcatgc atgtgacggt tgaattgggc ttgtagacta cttatgaagc
    11581 aacttctgac ctgattaacc gtgcgtattc ttatgaattg taggtggaaa cggtcaagcg
    11641 tttgagaaag tatcccaaga ttgagattgt ttcccatttg attaatggtt tgcctggtga
    11701 aacccatgag atgatggttg aaaatgtccg ccgttgtgtc acgaataacg atattcaagg
    11761 gattaaactg catttgctcc atcttatgac aaatactcgt atgcaacgag attaccatga
    11821 gggacgttta caattgatga gtcaggacga atatgtcagg gtcatctgtg accaactgga
    11881 aattattccc aaacatatcg tcatccatcg aatcacagga gatgcaccta gggatatgct
    11941 gattgggctt atgtggagcc tcaataaatg ggaagctctc aacagcattg agatggagat
    12001 gcgacgtcgt ggaagtgttc aaggatgcaa ggctgtaaaa caggagtttg aaaatgaaaa
    12061 gaccacttga gatggcacat gattttttgg ctgaggtcgt gacaaaagag gatgtcgtag
    12121 tggatgcgac tatgggaaat ggtcatgaca cgcttttttt agccaagcta gccaagcaag
    12181 tctatgcctt tgatattcag aagcaagcct tgaaaaagac ccaagagcgt ttgcatcagg
    12241 ctggcttgac aaatgcccag ttaatcttgc aaggccatga gacactggac cagtttgtga
    12301 caaaaactaa ggcagggatt tttaatctgg gctatttgcc gtcagctgat aagtctgtca
    12361 tcacccgacc gcagacaacc attgaagcat tagaaaagct atgtcatttg cttgtcaaag
    12421 gtggacgaat tgctattatg atttactatg gtcatgaagg aggcgacctc gagagagatg
    12481 ctgtcttgga ttttgtgatc cagttgaacc aacaagagta cacagctgcc atttaccgaa
    12541 ctttaaacca agtcaacaac ccgccgtttt tagtgatgat tgaaaaatta gagagataca
    12601 gacatggata aacaatacct acacgaaaag ctggatgcca tgcgccagaa ttttgttgaa
    12661 tcaacccacc acgaacgagc ggtgggcgtg ctagaccaag cgcatatgag caaaaaaatg
    12721 cttaaaatca agaaaaaatt agttgctctt gaaatggaac ggtgccagag aaaaattgag
    12781 cacaaagact gttccaagat tgaccaaaaa atcaaagagc agaaggagat atttgaatcc
    12841 tgttgtaaaa aagattaagg aggacgtgcg tggaattact gatttacctc atcctatttt
    12901 tactggtttt gattgtctca agtacaacca ataagctcct gccctttttg cctctccctt
    12961 tggtgcagat tcttttggga attgtgattg gtctcttttt acccaatact gactttcacc
    13021 ttaatacgga gttgtttttg gcactggtta tcggaccctt gcttttccga gaggctgaag
    13081 aagcagatgt tacggctatt ttaaaacact ggcgaatcat tgtttatctc atatttccag
    13141 tgatttttat ctcgaccctg agtttgggtg gcttggccca tcttctttgg ttcagccttc
    13201 ccttggcagc ttgcttggct gttggtgcag cccttggtcc tacggacttg gtggcctttg
    13261 cctctctttc ggagcgtttt agctttccta agcgcgtgtc caatattctt aagggcgaag
    13321 gactcttgaa tgatgcttct ggtttggtgg cttttcaggt agctttgaca gcttggacaa
    13381 ctggagcttt ttctctgggg caagctagca gttcgctcat cttttcaatc ctaggcggtt
    13441 ttttaattgg atttttaaca gccatgacca accgcttcct ccataccttc ttgctaagtg
    13501 tgcgcgcaac ggatattgcc agtgaacttt tattagaatt gagtttgcct ctagtgacct
    13561 tctttctggc agaagaagtc catgtttcag ggattattgc cgtcgtagtt gctggaattt
    13621 taaaggcaag tcgcttcaag aaaatcacgc tcctcgaagc ccaagtggat acggtgaccg
    13681 agacggtctg gcatacagtg acctttatgc tcaacggttc tgtctttgtg attttaggga
    13741 tggagttgga aatgatagca gaacctatct tgaccaatcc aatctataat cctctacttt
    13801 tattgctatc tctcatcgcc cttacctttg tcctctttgt cattcgtttt attatgatct
    13861 atggctatta tgcctataga acccgacgcc tcaagaaaaa gctaaataag tatatgaagg
    13921 acatgtttct cttgaccttt tcaggtgtta agggaacggt gtcgattgct acgattctct
    13981 tgataccaag taatctagaa caggagtatc ctctcttgct tttccttgtt gcaggtgtga
    14041 cgcttgtcag ctttttaaca ggtctcttgg tcttgcctca tctttctgat gaagaggaag
    14101 aaagcaagga ttatctcatg catatcgcca ttttgaatga agtaacgcta gagttggaaa
    14161 aagagttgga agacaccaga aataaacttc ccctctatgc ggctattgac aattatcatg
    14221 gacgtattga aaatctcatt ttaagccaag aaaaccagga tgatcaagaa gattgggctg
    14281 ctttgaaact cttgattctt agtattgaaa gtgatggttt ggagcaggcc tatgaagagg
    14341 ggaacattag caatcgtgct taccgagttt accaacgtta tctgaaaaat atagaacaag
    14401 gaatcaatcg taaacttgcc tcaagactga cctattattt ccttgtttct ttgcggattt
    14461 tacgttttct ccttcatgaa gtttttactc tcggaaagac cttccgtagc tggaagaaca
    14521 aggagcaaag ccgtctccgt gctcttgatt atgaccaaat tgcagagctc tatcttgcca
    14581 atacagagat gattattgaa agtttggaaa acctgaaggg agtctacaga cgctctttga
    14641 ttagttttat gcaggagtct cgtcttcgag aaacagctat tatcagcagt ggtgcctttg
    14701 tcgaacgggt tatcaatcgt gtcaaaccca acaatatcga tgaaatgctg agaggctatt
    14761 atctggagcg caagttgatt ttcgaatacg aagaaaaacg attgattacg actaagtatg
    14821 ccaagaaatt acgacaaaat gtaaataact tagagaacta ttccttgaag gaagctgcca
    14881 ataccctacc gtatgatatg gtggaattgg taagaagaaa ttagttaata ctcttcgaaa
    14941 atctcttcaa accacgtcag cgtcgcctta ccgtatgtat gtgactgact tcgtcagtct
    15001 tatctacaac ctcaaaacag tgttttgagc agcttgcggc tagcttccta gtttgctctt
    15061 tgattttcat tgagtataag attataagtg aaggagtgtg acatgaaaaa gtggtggaaa
    15121 gagctgatag acaagccttt attaaaagct tttttgcatt attatcaagc atcagatagt
    15181 gagttgacca gtgtcgcagt agcctactat tggttgattt cgattttccc cctgcttttg
    15241 gtggtggtca atatcctccc ctattttcag attcctgtgg gagaatttct gggctttatg
    15301 aaagacgtcc tgcccccaag cctctatgaa ggtgtggaaa aaatagccag agaagtcttg
    15361 acgcaacctt caacaggttt attgagtttt tctgttttat cggcgttatg gagtttttca
    15421 aaatctatga atttcttgca aaaagctttt aacaaggctt atggcgtcga aaagagtcgt
    15481 ggacttattt cccatcagat gctaagtctc ctagtcagtt ttggcttgca gctcctcttt
    15541 gcgtttgcct tgtttttgat cttatttggt cagatgattt tggctttact tgctcattat
    15601 tggacaaaag atggcattat ctatcaggct ttacaagggt tggcaggtcc tctgatttac
    15661 gccctcctct ttgctatctt ggtcatgctt tattattttc ttcccaatat atctaacagg
    15721 aaaattagct ataccctacc aggcagtgcc tttgttctct tagtgatttt aggtttacta
    15781 actctgttct ctagttatct caattactat gtccatcatt tggtggatgt ccgaatttta
    15841 ggttccgttc ttcttgttgt tatgatgttt tggtttatct tgattgctaa aattgttatc
    15901 ctaggcgcgg ttatcaatgc cagtatgcag agtttgaaag atccggtctt taaaaaagac
    15961 taactattta tccattacaa aagcgcatag tatcaaaact ttatagaacc ttgatactat
    16021 gcgcttttgt gctttgacag ttttttgtat agtttttgtc caagatttct aaatcatctg
    16081 attaaattcc tattttcccc tatcattgtc cctgtttttt cgaaaatgga aggagtataa
    16141 taaatctatc aataaaatga taggaggaac tttatgggtc atattttctt ttttctaagt
    16201 gtctttttgg cagggattct atccttcttt tctccttgta tcttaccttt gttaccggtc
    16261 tatacaggag tgttactaga tgataaggat ggtgctcagg cttctagcgg caaattttca
    16321 atctcagtta ctagtttatt acgaactctg gcctttatag caggaatttc ctttatattt
    16381 attttgttgg gctatggagc tggtttttta ggcgatttgc tttatgcttc ttggttccaa
    16441 tatcttactg gggcaattat tatccttctt ggtttgcacc aaatggagat tctacacttt
    16501 aaggggcttt ataaggaaaa gaggctacaa ctgcaaggac aggggcaaaa tggtaagggc
    16561 tatagtcagg catttttatt gggcttgacc tttagttttg cttggacgcc ttgcgtgggg
    16621 ccggttctgg ggtctgtttt ggccttggcg gcttcaggtg gttcaggagc ttggcaggga
    16681 gctggtctca tgttggtgta tacgctgggc ttggcgctac cattcttgct tctagctctg
    16741 acctctagtt atgttttgaa acatttccga aaacttcatc cctatctcgg aatcctcaaa
    16801 aaagtgggtg gttttctcat tattgtgatg ggactcttgg ttctgtttgg aaatgcttca
    16861 attttaagtc aattatttga ataaaatgga aaggaatatc aatatgaaaa aatggcaaac
    16921 atgtgttctt ggagcaggtt cgctcctttg tttgacggct tgttcaggca agtccgtgac
    16981 tagtgaacac caaacgaaag atgaaatgaa gacggagcag acagctagta aaacaagcgc
    17041 agctaaaggg aaagaggtgg ctgattttga attgatggga gtagatggca agacctaccg
    17101 tttatctgat tacaagggca agaaagtcta tctcaaattc tgggcttctt ggtgttccat
    17161 ctgtctggct agtcttccag atacggatga gattgctaaa gaagctggtg atgactatgt
    17221 ggtcttgaca gtagtgtcac caggacataa gggagagcaa tctgaagcgg actttaagaa
    17281 ttggtataag ggattggatt ataaaaatct cccagtccta gttgacccat caggcaaact
    17341 tttggaaact tatggtgtcc gttcttaccc aacccaagcc tttatagaca aagaaggcaa
    17401 gctggtcaaa acacatccag gattcatgga aaaagatgca attttgcaaa ctttgaagga
    17461 attagcctag gaggtgtctt atgaatgata agttaaaaat cttcttgttg ctaggagtat
    17521 tttttctagc cataaccggt ttctatgttc tattgatacg aaatgcaggg cagacagatg
    17581 cctcgcaaat tgaaaaggcg gcagttagcc aaggaggaaa agcagtgaaa aaaacagaaa
    17641 ttagtaaaga cgcagacttg cacgaaattt atctagctgg aggttgtttc tggggagtgg
    17701 aggaatattt ctcacgcgtt cccggggtga cggatgccgt ttcaggctat gcaaatggta
    17761 gaggagaaac aaccaagtac gaattgatta accaaacagg tcatgcagaa accgtccatg
    17821 tcacctatga tgccaagcaa atttctctca aggaaatcct gcttcactat ttccgcatta
    17881 tcaatccaac cagcaaaaat aaacaaggaa atgatgtggg gacccagtac cgtactggtg
    17941 tttattacac agatgacaag gatttggaag tgattaacca agtctttgat gaggtggcta
    18001 agaaatacga tcaacctcta gcagttgaaa aggaaaactt gaagaatttt gtggtggctg
    18061 aggattacca tcaagactat ctcaagaaaa atccaaatgg ctactgccat atcaatgtta
    18121 atcaggcggc ctatcctgtc attgatgcca gcaaatatcc aaaaccaagt gatgaggaat
    18181 tgaaaaagac cctgtcacct gaggagtatg cagttaccca ggaaaatcaa acagaacgag
    18241 ctttctcaaa ccgttactgg gataaatttg aatccggtat ctatgtggat atagcaactg
    18301 gggaacctct cttttcatca aaagacaaat ttgagtctgg ttgtggctgg cctagtttta
    18361 cccaacccat cagtccagat gttgtcacct acaaggaaga taagtcctac aatatgacgc
    18421 gtatggaagt gcggagccga gtaggagatt ctcaccttgg gcatgtcttt acggatggtc
    18481 cacaggacaa gggcggctta cgttactgta tcaatagcct ctctatccgc tttattccca
    18541 aagaccaaat ggaagaaaaa ggctacgctt atttactaga ttatgttgat taatactctt
    18601 cgaaaatctc ttcaaaccac gtcagcgtcg ccttaccgta tgtagggtta ctgacttcgt
    18661 cagttttatc tacaacctca aagctatact ttgagctgac ttcgtcagtt ttatttacaa
    18721 cctcaaagcg gtactttgag aaacctgtgg ctatcttcct agtttacttt ttgattttta
    18781 ttgagtataa gaggtctttc ctaagcagtt agaggagaat tttgctatac tgatactagt
    18841 aagtggtaaa ggagcagatc atgacctaca caatcttaat cgtagaagat gaatatctgg
    18901 taagacaagg tttgactaaa ctggtcaatg tagcagccta cgatatggaa atcatcggtc
    18961 aggctgaaaa tggaaggcag gcttgggaat tgatccaaaa gcaggtgcca gatatcattt
    19021 taaccgatat caacatgcct catctaaatg gcatccagtt ggccagtctg gtacgagaaa
    19081 cctatcctca ggttcatttg gtctttttaa caggttacga tgattttgat tatgccttgt
    19141 ctgctgtcaa actaggtgtg gacgactacc tgctcaaacc cttttctcgt caggatattg
    19201 aggaaatgtt ggggaaaatc aaacaaaaac tagacaagga agagaaagaa gagcagttac
    19261 aagatttatt gactaatagg tttgaaggaa acatggccca gaaaatccag tctcatctgg
    19321 ctgatagcca atttagttta aagtctttag ccagtgactt aggttttagt ccgacctatc
    19381 tgagttcctt gattaagaaa gagttgggct tgccttttca ggattatctg gtgagagaac
    19441 gtgttaaaca agccaagctc ttgcttttaa ctacagatct gaagatttat gagatcgcag
    19501 agaaggttgg ttttgaagat atgaactatt ttacccaacg ttttaagcag attgcaggtg
    19561 tgacacctcg tcagtttaag aagggagaag accgatgaag cgttcttctc ttttagttag
    19621 aatggttatt tccatctttc tggtctttct cattctccta gctctggttg gaactttcta
    19681 ctatcaatca agttcttcag ccattgaggc caccattgag ggcaacagcc aaacgaccat
    19741 cagccagact agccacttta ttcagtctta tatcaaaaaa ctagaaacca cctcgactgg
    19801 tttgacccag cagacggatg ttctggccta tgctgagaat cccagtcaag acaaggtcga
    19861 gggaatccga gatttgtttt tgaccatctt gaagtcagat aaggacttga aaactgttgt
    19921 gctggtgacc aaatctggtc aggtcatttc tacagatgac agtgtgcaga tgaaaacttc
    19981 ctctgatatg atggctgagg attggtacca aaaggccatt catcagggag ctatgcctgt
    20041 tttgactcca gctcgtaaat cagatagtca gtgggtcatt tctgtcactc aagaacttgt
    20101 tgatgcaaag ggagccaatc ttggtgtgct tcgtttggat atttcttatg aaactctgga
    20161 agcctatctc aatcaactcc agttggggca gcagggcttt gccttcatta tcaatgaaaa
    20221 ccatgaattt gtctaccatc ctcaacacac agtttatagt tcgtctagca aaatggaggc
    20281 tatgaaaccc tacatcgaga caggtcaggg ttatactcct ggtcacaaat cctacgtcag
    20341 tcaagagaag attgcaggaa ctgattggac ggtgcttggc gtgtcatcat tggaaaagtt
    20401 agaccaggtt cggagtcagc tcttgtggac cttgcttggg gccagtgtca catctcttct
    20461 tgtctgtctc tgcttagtgt ggttcagtct taaacgctgg attgctcctt tgaaggattt
    20521 gagagaaacc atgttggaaa ttgcttctgg tgctcaaaat cttcgtgcca aggaagttgg
    20581 tgcctatgaa ctgagagaag taactcgcca atttaatgct atgttggatc agattgatca
    20641 gttgatggta gctattcgta gccaggaaga aacgacccgt cagtaccaac ttcaagccct
    20701 ttcgagccag attaatccac atttcctcta taacactttg gacaccatca tctggatggc
    20761 tgaatttcat gatagtcagc gagtggtgca ggtgaccaag tccttggcaa cctatttccg
    20821 cttggcgctc aatcaaggca aggacttgat ttgtctctct gacgaaatca atcatgtccg
    20881 ccagtatctc tttatccaga aacaacgcta tggagataag ctggaatatg aaattaatga
    20941 aaatgttgcc tttgataatt tagtcttacc caagctggtc ctacaacccc ttgtagaaaa
    21001 tgctctttac catggcatta aggaaaagga aggtcagggc catattaaac tttctgtcca
    21061 gaaacaggat tcgggattgg tcatccgtat tgaggatgat ggcgttggct tccaagatgc
    21121 tggtgatagt agtcaaagtc aactcaaacg tgggggagtt ggtcttcaaa atgtcgatca
    21181 acggctcaaa cttcattttg gagccaatta ccagatgaag attgattcta gaccccaaaa
    21241 agggacgaaa gttgaaatat atataaatag aatagaaact agctaactcc cagtcaattc
    21301 tgggagtttt atgcgtaatt gggcaaattt tctaggttgt ctatcttgct aaaaacaaga
    21361 aaaaacggta tgatagaaga gtgacaacag aggtaacaga gatgaacgag acacagattc
    21421 aaagagaaac acgtcaggta gtggaagatg ttttagaaaa gaccaatttg aagcaggggg
    21481 ccctttttgt tttaggtcta tcttctagtg aggtgctagg tggtcagatt gggaaagaat
    21541 ccagtcaaga gattggtgag ctgatagtgg agactatctt gggtattcta ggtagtagag
    21601 gtatccattt agcagttcaa ggttgtgagc atgtcaatcg ggctctcgtt gttgaacgtc
    21661 aggtggcaga gcagtttgat ctggaaattg tcagtgtcca tcctactctt catgcaggag
    21721 gttcggggca gttggcagcc tttaagttta tgcaggatcc agttgaggtt gaatttatca
    21781 aggctcatgc tggattggat atcggagaca ctgcaattgg catgcatgtc aagcatgttc
    21841 aggttccgat tcgccctatt ttgagagaga ttggtcatgc ccatgtaacg gcactggcta
    21901 gtcgtccaaa attaatcgga ggtgcgcgtg cgcactatcc gcaagatgct attaggaagt
    21961 cttgagaatg aataaaggag ataaaagtgt ttaaaaaaga ccgtttttca attcgtaaga
    22021 ttaagggagt tgtaggctct gtatttcttg gaagcctttt gatggctcct tctgtagtgg
    22081 acgcagccac ctatcactat gtaaataaag agattatttc acaagaagct aaagatttaa
    22141 ttcagacagg aaagcctgac aggaatgaag ttgtatatgg tttggtgtat caaaaagatc
    22201 agttgcctca aacagggaca gaagcatctg ttttgacagc ttttggtttg ctgactgttg
    22261 ggagcttgct tttaatctac aagagaaaga aaattgctag cgtctttcta gttggagcta
    22321 tgggattggt agttcttcct agtgcagggg ctgtagaccc agttgcgacc ctagcgctgg
    22381 ctagtcgaga gggtgttgtt gaaatggatg gctatcgcta tgttggttat ctatcaggtg
    22441 acatcctcaa aacgcttggc ttggacactg ttttagaaga aacctcagca aaacctggag
    22501 aggtgactgt agtcgaagtt gagactcctc aatcaataac aaatcaggag caagctagga
    22561 cagaaaacca agtagtagag acagaggaag ctccaaaaga agaagcacct aaaacagaag
    22621 aaagttcaaa ggaagaacca aaatcggagg taaaacctac tgacgacacc cttcctaaag
    22681 tagaagaggg gaaagaagat tcagcagaac cagctccagt tgaagaagta ggtggagaag
    22741 ttgagtcaaa accagaggaa aaagtagcag ttaagccaga aagtcaacca tcagacaaac
    22801 cagctgagga atcaaaagtt gaacaagcag gtgaaccagt cgcgccaaga gaagacgaaa
    22861 aggcaccagt cgagccagaa aagcaaccag aagctcctga agaagagaag gctgtagagg
    22921 aaacaccgaa acaagaagag tcaactccag ataccaaggc tgaagaaact gtagaaccaa
    22981 aagaggagac taaaacagct aaggggacgc aagaagaagg caaagaaggt caagcaccag
    23041 tacaagaagt aaacccagaa tataaagtaa caacaggtac agttgagaag tctaccgaaa
    23101 gtgaattaga tttcacaaca gaagtagttc cggatgacac aaaatatgta gatgaagaag
    23161 ttgttgaacg tcaaggatct aaaggagttc aagttacgaa aacaacttac gaaacagtgg
    23221 aagttgtaga gacagacaaa gtcctttcta caactacaga agtgaaaact cctgttgttc
    23281 ctaaagtcgt taaaaaagga acaaaaccag ttgaaggaac agcagttgaa acaagagaag
    23341 aagtcattcc ttttgctaca aaagaacaag aagatgacac tttaaaacgc ggaacaagac
    23401 aagtagctca agaaggtgta aacggtaaga aacaaattac tgaaacctat aaaacaattc
    23461 gcggagaaaa aacaaacgaa gctccaacag tagaagaaac agttctccaa gcacctcaag
    23521 atgagattat caaaaaaggc acaaaaggtt tagaaaaacc aaccttagaa tgggttaaaa
    23581 cagataaaga tgtcttgaag aagagtgcga cagccagtta tacattgaat aaaccagatg
    23641 gggtagaaat caaatccatc aaagtagctc taaaagataa tactggaaca gttattaaag
    23701 aagtaacggt agaagaaaat aacttaaacg ctactttaga caacttgaaa tattatcaag
    23761 gttatacact atccacaacc atggtctata atcgaggcga aggcgaagaa actgaaatgt
    23821 tagaagataa agaagttcag ttagacctta aaaaagttga aatcaaaaac atcaaagaaa
    23881 ctagcttgat gagtgtggat gatgctggtg ttgaaacaga taagagctta cttactgaaa
    23941 aaccgacaga cgttgctcca ctttacctac gagtgacaac tcatgataac aaaacaacaa
    24001 gactggcagt aagttcagtt gaagaagttg ttgttgatgg aaaaacattg tacaaagtgg
    24061 tagctaaagc tcctgactta gttcaacgta gagaagatga tacactaagc gaagagtatg
    24121 tacattactt tgaaaaacaa ttaccaaaag tagataatgt gtactatagc tttaacgagt
    24181 taattacaga tatgcaaaaa aatcctactg gtacattcaa actaggtgca gatcttaatg
    24241 cagcgaatac tccaactcca agtaaatcat atgtaacagg tgaatttaaa ggtaaattat
    24301 caagtgttga tggtcaacat tatacgattc acaatactgc gcgcccatta tttaacaata
    24361 ttgttggtgg taccgttaaa aatattaatc ttaacaatgt aaatatcgat atgccttggg
    24421 ctgatcaaat tgcatctgta gcaaatgtga tcaaaggtgg tagccttatt gagaatgtta
    24481 aagtcaaagg taatgtgctc ggcagaaact gggtatctgg tttcattgat aaaattgaca
    24541 gtggtggtag attagttaat gttgcattta ttggtaatgt aacttctgtt ggagatgggg
    24601 ataagttctt aacaggtatt gttggagaaa actggaaagg atatgtcgaa aaagcatacg
    24661 ttgaagctaa tattaaaggt aagcgagcta aagctgctgg tatatcttat tggtcgcaaa
    24721 atagcggaga taataatgct gtcggtagag atggagcaat taagaaatct gtcgttaaag
    24781 gttcaataga tgtagaaaaa ccaattgaag ttggtggcgc tgttggaagt ttaaattatc
    24841 ttggttatat agaagacact gttgctatga tgaaagttaa gaacggtgaa attttctacg
    24901 gttcgcatga tatcgatacc gatccatatt acacaggaga acgagtaaat agaaatttca
    24961 ttgttgacgg tgtaagtgaa ggtaaatctt cgtatacata ctctaaacaa caaaagcgta
    25021 ttaaatcaat atctcaagag gaagcagata agaaaattaa agaattgggt atcacagcag
    25081 ataaatttac aattatcgat ccaattgtaa ataaacttaa caacatcaaa caaaaagctg
    25141 atacttataa agatactcaa gattacaaag tagaccgtga acttgcttat cgtaatatcg
    25201 aaaaacttca accattctac aataaagagt ggattgtaga ccaaggtaat aaagttccat
    25261 caaattctaa attattaact acagaagtat tatctgttac aggtatgaaa gatggtcaat
    25321 ttgtgactga cttatcagaa attgataaaa ttatgattca ctatgcggat ggtacaaaag
    25381 aagaaaaatc tgtatcacct aagcctacat caaacgtaga acaagtaaaa gaatatggta
    25441 ttacagattt aggagatgtc gtttacacac caaatatggt ggttaaagac cgtgctcaat
    25501 tactaagtga tgttaaagcg aaattagata cgattactct tgaatctcct gaagttcgtg
    25561 cgataacagg taatgttgga gcattatact tagaagaaag ttttgcagaa gtaaaaggaa
    25621 atcttgataa attagtaaaa gctcttgttg aaaatgaaga tcatcagtta aatagtgatg
    25681 aggcagccat caaagcattt cttaagaaag tagaagataa taaagctaaa atcatgatgg
    25741 cacttactta cctcaatcgt tattatggta ttgaatatgg tgacttaaac attaagaata
    25801 taatgatgtt taaaccagat ttctatggca agacaccaag tgttattgat agattaattc
    25861 gaattggttc gcaagaaaag aacttgaagg gtgatagaac ccaagatgca tatcgtgaaa
    25921 ttattgcagg agatactggt aaaggtgatt tacgtagttt cttagattat aatatgcgtc
    25981 tcttcacaaa tgatacagat cttaatgact ggtttatcca ttcagcgaaa aatgtttatg
    26041 ttgtagaacc agaaacaaca aatccagatt tcaaaaataa acgtcatcgt gtttttgatg
    26101 gtctgaataa taatatgcat gcacgtatga ttttaccatt attgaacttg aaaaaagcac
    26161 atatctttat gatttcaacc tataatacta tggcttatag ttcatttgaa aaatatggta
    26221 aaaatacgga agctgaacgt gaagcgttca aggaacgtat caattatgta gctaaagctc
    26281 aacaaacata cttagacttc tggtcacgtc ttgcacttcc aaatgttcgt gatagacttc
    26341 ttaagagtca aaatatggtt cctacacctg tatgggataa tcaagcttat gcgggtatta
    26401 aggatgctaa tcgtcgtgga tatggtacag atggtaaggt agcgacacca attcgtgagt
    26461 tatttggtcc aacagacaga tggcatcaaa ttaattggaa tatgggagct atggctaaag
    26521 tttatggaaa accatatgaa gatgaacaag ttttcttcat ggtaacaaat atgttagagg
    26581 actttggtat ttcagccttt acacatgaaa caactcacat aaatgaccgt atggcatatc
    26641 ttggtggtca tggacatcgt ccaggtacat accttgaagc atatgctcaa ggtatgttac
    26701 aaacacctga taaatcaaca tcaaatggtg agtatggagc attaggtatt aatatggctt
    26761 atcatcgtca aaatgacgga aatcagtggt ataacccaga tcctgataaa ttacaaagtc
    26821 gtgaacaaat tgatcactat atgaagaact acaatgatgc tcttatgatg ttagatcatc
    26881 ttgaggctga tgctgtatta ccgcagttaa atggaaatac gagtcgctgg ttcaagaaaa
    26941 tggatagaca ataccgtagt ggaaattcag gtcatcagtt cgataaaatt cgtgagttga
    27001 cagaggatga gaaaaaagta gcaatcaata caattgatga tttaattact aataacctaa
    27061 taacgaaaca tggtgctcct ggtgatggta cttataatcc aacggacttt aggtctgctt
    27121 atgttaatat gaacatgatg actggtattt atggtggaaa tacaagtaca ggtgcaccgg
    27181 gtgcagcatc atttaaacat aatacattcc gtatgtgggg atactttgga tatgagaatg
    27241 gatttgttgg atatgcttct agcaaatatc aaaatgcagc caataaagaa aataatagga
    27301 tgttaggtga tgacttcatt attaagaaag tttcaaatgg aagattcact aaccttgaag
    27361 attggaagaa agagtactat aaagaagtga aggcaaaagg tgaaaaagga tttactgcaa
    27421 ttgagattga tggtaaacaa attaccaatt atgctgaact aaaagtctta tttgataagg
    27481 cggttgaggc tgatctagca ggtggaggaa cagctaaaac tgtagaactt aaatcgaaag
    27541 tctttaaagc acttcttaag aattcagacg gattcacagg aaatcttttt aaagcataga
    27601 ttgtattaaa tagatgagta aaaaggtaga ttaagttttt cttgatctgc ctttttatgc
    27661 tatacttaag gtatgcatag aaaaacagtg attgatttta gggctttagg ggagagacac
    27721 atctttactc agcctatcaa agagttaaaa accagagatt taacagaagt aacagcctta
    27781 ttggcacaag tggaaagcta ccaagagcaa ggttattatg tggtggggta tgtcagctac
    27841 gaggctgcac ctgcttttga ggaaaaatta gcagttcaca aggatcccct actgggagag
    27901 tacctgcttt attttactgt tcatgatagc gtagaaactt cccctattcc tctgacttat
    27961 gaggatattg atttgccctc aaattggcag gaagtaacgt ctgcagcaga ctatgaaaag
    28021 gccattgccc aaattcacca tcatttacgg cagggagata cctatcaggt caactacacc
    28081 gtccaactta agcaaaagtt aaatgccaat ccttttgcca tctacaatcg tatggtggta
    28141 gagcaggagg cgggctacaa tgcctatgtg gaacatgacg agatggcagt gatttccatg
    28201 agcccagagc tcttttttga gcaaaatgat cgcgagttga caacacgacc aatgaagggg
    28261 acgactcagc gtggggtaac tgaccaagaa gatcttgaac aggccagttg gttggaacag
    28321 gatcccaaaa atcgctctga aaatatgatg attgtggacc tcttgcgcaa tgatatgaac
    28381 cgtatttctg aagttgggag cgagcacgtg gagcgtctgt gtcaggtaga gcagtattca
    28441 actgtttggc agatgacttc gaccatcaag agtcagttgc gagaggatgt ggaccttgtt
    28501 gaaatcttcc gctcactctt tccttgtggt tccataacgg gtgcaccgaa aattgcgaca
    28561 atggagatta tcaaggactt ggagcctcaa ccgcgtggag tctactgtgg aacgattggt
    28621 ctcttgcttc caaatggacg acggattttt aatgtggcca ttcgtaccat tcaacttcac
    28681 aaaggtcaag ccatttatgg agttggcgga gggattactt gggatagcac atgggaatct
    28741 gaataccgag aggttcatca aaaggcagca gttctttatc gtaaacaagc tcgcttccaa
    28801 ctgattacga caggggaaat cagccagaag aacctgctgt ttgaagatca acatctggaa
    28861 agactgagaa aagccagtcg ttattttgcc tttccttttg atgcagaaga cttgggacac
    28921 aagattgagg aagagtgtca ggattgtgaa gctaatcaag attaccgctt gcgaatcagc
    28981 cttagcaaat ctggagagat agaagtcaat cgtcaagtat taacccctct cagtacaagc
    29041 ttttgtcagg cccaagtctg ccttcaggaa gctgctttga atcaatcctt tacctacttt
    29101 aaaaccactc accgaccgca tttgaaccta ggagaacaag agaagattta ccataataag
    29161 tcaggagaac tgcttgaaac ctctatagga aatttggttc tgaaaatcgc tggaaaactc
    29221 tacacaccgc ctatccgact tggaatcttg ccaggaattt accgtcagta tttgctagaa
    29281 acaggacagg tagaagagaa agtcttgacc ttggcagatt tagcccaagc agaagctatt
    29341 tacggctgta atgcagtgag aggcttgtat gaactaagcc ttgaggagaa ctagatgaaa
    29401 ctgatatttt tgcatgggtt agggcagtca gcagagtctt ggaaagaagt tcggaatcta
    29461 ctgacagatt atccttctga ggctatcgag ttatttcctt ctggagttag taactatcaa
    29521 caagctaagg agcgagttta tcagcaccta gctcaagaga cagaaccttt tgttttgatt
    29581 ggattgtcct taggtgctgc cctggcacta gaactttcca gttacgattt accaaatctt
    29641 cgagctttga ttctgtcagg atgcccgctt aaattagcag ggaatatcct attttatctt
    29701 caattgctga tttttaaact acttcccaaa agagtatttg aaaaacaggg agcagacaag
    29761 actcttatgg tcggagtttc tgaggaattg aagacacttg atttaacgga tatagcaggg
    29821 acttgctcct atccaacctt actaatttgt ggcagcaaag ataaaccgaa tcttagttct
    29881 atgaaagctc tccatagact gttaacagat tcgcagtttc agatcattcc tgatggccct
    29941 catgtcttga ataaggcaaa accaaaggag tttgtagaaa agaccagaag tttccttgaa
    30001 ttgctgaaat aagtttgata aaataatatt gaaatcgata tcataattat gggagaaaga
    30061 aatgaataaa cgtctatttt taaaaatgag tctggtgacg ttgccaattt tagccttgtt
    30121 ttcacaacca gttttggcgg aagaaaacat ccatttttcg agctgtaagg aagcttgggc
    30181 gaatggctat tcggatattc acgagggaga acctggttat tctgccaagt tagaccgtga
    30241 tcatgatggt gtggcttgcg aattgaaaaa tgctcctaag ggtgctttta aagcaaaaca
    30301 gtcaacggct attcaaatca acacaagttc agcaacaaca agtggttggg ttaagcagga
    30361 cggcgcttgg tactactttg atggaaatgg aaatctagtg aaaaatgcat ggcagggaag
    30421 ctattacctg aaagctgatg gtaaaatggc acagagtgaa tggatttatg actcttctta
    30481 tcaagcttgg tattatttga catcagatgg ttcttatgca aaaaatgcat ggcaaggagc
    30541 ttattacctt aaatcaaacg gtaaaatggc acaaggtgag tgggtttatg attcttctta
    30601 ccaagcatgg tattacttga aatcagatgg ttcatatgct cgcaatgcat ggcaaggaaa
    30661 ctactatttg aaatcagatg gtaaaatggc taaaggtgaa tgggtttatg ttgccaccta
    30721 tcaagcttgg tattatttga catcagatgg ttcttatgct tacagtacat ggcaaggaaa
    30781 ttactatcta aaatcggatg gtaaaatggc tgtcaatgaa tgggttgatg gtggacgtta
    30841 ttatgttggc gctgacggag tttggaagga aggtcaagca agtacagctt cttctagtaa
    30901 tgatagcaat agtgaatatt ctgctgcttt aggaaaggca aaaagttata attcgttatt
    30961 ccacatgtca aaaaaacgta tgtatagaca attaacttct gattttgata aattttcaaa
    31021 tgatgcagct caatatgcca ttgatcatta gatgattaac agatactggt aggcgaaaaa
    31081 attccttata attcatttac gcaaaccttt gcataagtga atggattttg atatactagt
    31141 actgtaagca ttttcaatta ctacacaatg aaaaaggaga atatgatgag tcaaaagatt
    31201 attgggattg accttggtgg aacttctatc aaatttgcaa tcttaacaac agcaggagaa
    31261 atccaaggaa aatggtcaat caagaccaac attttggatg agggaagtca tatcgttgat
    31321 gatatgattg agtctattca acatcgtttg gacttgcttg gattggcagc agcggacttc
    31381 caaggcattg gaatgggatc accaggtgtg gttgaccgtg acaaagggac tgttatcggt
    31441 gcctacaact tgaactggaa aacccttcaa ccaatcaaac aaaagattga aaaagctttg
    31501 ggcattccat ttttcatcga taatgatgcc aacgtagcag ctcttggtga gcgctggatg
    31561 ggtgctggag ataaccaacc agacgttgtc tttatgacac tcggtactgg tgttggtggt
    31621 ggtattgtcg cagaaggcaa attgcttcat ggtgttgctg gtgcagcagg tgaacttggt
    31681 catatcactg ttgactttga ccaaccaatc tcatgtactt gtggtaaaaa aggctgcctt
    31741 gagacagttg cttcagcaac agggattgtc aacttgactc gtcgctatgc cgatgaatac
    31801 gaaggcgatg cagccttgaa acgcctgatt gataacggag aagaagtaac tgctaagact
    31861 gtctttgatc tcgcaaaaga aggagacgac cttgctttga ttgtttaccg taacttctca
    31921 cgttacttgg gaatcgcttg tgctaacatt ggttcaatcc taaacccatc aacaatcgtc
    31981 atcggtggtg gtgtgtcagc tgcgggagaa ttccttctac aaggtgttca aaaagtttac
    32041 gatgaaaata gtttcccaca agtacgcaca tctactaaat tagctcttgc aactctagga
    32101 aatgacgctg gagttatcgg agcagcatca cttgtattgc aataagataa tgagagagga
    32161 aaatgctaac ctagagttag taatgttcct cttttatttt ttatgctata ctagttagga
    32221 caatgaatga ggtgaaacga aatgacaaaa gcagatacga tttttaaaga gaatattgaa
    32281 cgcattctaa aggaaggtgt tttctcagag caggctcgtc ctaagtacaa ggatgggact
    32341 gttgctaatt ccaagtatgt aactggtgcc ttttccgagt acgacttatc taaaggagaa
    32401 tttcctatca caaccttgcg tcccattgca atcaaatccg ccatcaaaga agttctctgg
    32461 atttaccaag accagtcaaa tagcttagag gtacttaatg ataagtacaa tgttcactac
    32521 tggaatgact gggaagtggg ggatacagga actattggtg aacgctacgg tgctgttgtt
    32581 aagaaacacg acatcatcaa caagcttttc aaacagttgg aagccaaccc ttggaaccgc
    32641 cgcaatatca tttcgctctg ggattaccaa gctttcgaag aaacagatgg gctactccca
    32701 tgtgcctttc agaccatgtt tgatgtccgc cgtatagatg gagaaatcta tctggatgcg
    32761 accttgaccc agcgctcgaa tgacatgcta gtagcccacc acatcaacgc tatgcagtat
    32821 gtggctttgc agatgatgat tgccaagcat tttggctgga aggttggaaa gttcttctac
    32881 ttcatcaaca acctccatat ctatgacaat caatttgaac aagctcagga attactccgt
    32941 cgtgaaccgt caaactgcca accacgtttg gttttgaatg ttcctgatgg aactaatttc
    33001 tttgatatca aagcagaaga ttttgaattg gtggattatg accctgttaa gccgcagttg
    33061 aagtttgacc tagctattta aaagaataga aaaaagaagt tgagaataat cccaacttct
    33121 tttgtttctt aacgtgatac gcggcgacga gctgcttttt tacggttttc ttcgatgaaa
    33181 gctgcttttt gctcttctgg ttcgattact ttctttttaa atgcgtatac tgcacctgca
    33241 acggcagcga cagttcctgc gacacctgtt acaagacctt tagcgaatcc tttagccatg
    33301 agtcttcctc ctttatattc tcaatcagcc agcctcctca agaggtcaca tttttctgac
    33361 tgaccttttt gtgttataat aatagtaacg aaaaaatggg aatttttcaa ggaaaaaaga
    33421 tgaaaacaaa aataattgtg attgttggac cgactgctgt tggaaagacg gctctagcta
    33481 ttgaagttgc aaagcgtttt aatggcgaag tggttagtgg agatagccaa caagtctatc
    33541 gaggacttga tattgggacg gccaaggcta gtccagaaga gcaggcagct gttcctcatc
    33601 atttaatcga tgttagagag ataaccgagt cttactcggc ttttgatttt gtttcagaag
    33661 ctaagatgac tattgaggat attcacagcc gtggcaagct agccattatc gccggtggga
    33721 ctggacttta tatccagagc ttgctagaag gttaccacct aggtggggag actcctcatg
    33781 aggagatttt agcttatcga gctagtttgg agccatattc agatgaggaa ttagcccatt
    33841 tggtggagca agcaggcctt gagattcccc agtttaatcg tcgtcgtgct atgcgtgcct
    33901 tagaaattgc ccattttggt caggatttgg aaaatcaaga gattttgtat gaaccgctga
    33961 ttatctgctt ggatgatgaa cgtagtcaac tttatgagcg tatcaaccac cgagtggatt
    34021 tgatgtttga ggctgggctt ttggatgagg ccaagtggct gtttgaccat tcccctaatg
    34081 tacaggctgc taaaggaatt ggctataagg aactctttcc ttatttccgt ggagagcaga
    34141 cctttgagga agctcgtgag agtcttaaac aggcgacccg tcgttttgcc aagcgtcagc
    34201 tgacctggtt ccgtaatcgc atgcaggtca ccttttatca gattggagaa tctggtgtac
    34261 aagaccgcat tttaagccag atagaggagt ttttagatga ttgaaacgga gaaaaaagag
    34321 gagcgagtcc tgctgattgg tgtggaattg cagggtatgg acagttttga cctctccatg
    34381 gaagaattgg ctagtttagc gaaaacggca ggggcagtcg ttgtagatag ctacagacaa
    34441 aaacgtgaaa aatatgattc caagaccttc gtcggctctg gtaagttgga agagattgcg
    34501 cttatggtgg atgcagaaga aatcactact gtcatcgtca acaaccgtct gaccccaagg
    34561 cagaatgtca atctagagga agttctgggt gttaaggtca ttgaccgtat gcagttgatt
    34621 ttggatatct ttgccatgcg ggctcgaagc catgaaggga agctccaagt ccacctagcc
    34681 caactcaaat acctcttgcc tcgcttggtt ggtcagggga ttatgctcag ccgtcaggca
    34741 gggggaattg gttcccgtgg tcctggtgaa agccagctgg agctgaaccg tcgtagcgtt
    34801 cgcaatcaaa tcacggatat tgagcgccag ctcaaggtgg ttgagaaaaa tcgtgcgact
    34861 gtcagagaaa aacgtttgga gtctagcact tttaagattg gtttgattgg ttatactaat
    34921 gctgggaaat caactatcat gaacatcttg accagtaaga cccagtatga agcagatgag
    34981 ctctttgcga ctctggatgc gacaaccaag agtattcatc tgggaggcaa tctccaagta
    35041 actttgacag ataccgttgg ctttatccaa gatttgccga cagagttggt gtccagtttc
    35101 aagtcaacct tggaagaaag caagcatgtg gaccttctgg ttcatgttat cgatgctagc
    35161 aatccttacc acgaggagca tgaaaaaacg gttctctcca tcatgaaaga cctggacatg
    35221 gaagatattc ctcacttgac gctttataat aaagcggatt tggtggagga tttcacgcct
    35281 acccaaacgc catataccct catttctgcc aagtctgagg acagtcgtga aaacttgcaa
    35341 gcattattgc tagataagat taaggaaatt tttgaagcat ttaccctgcg agtgcctttt
    35401 tcaaagtcct acaagattca tgatttagag agtgttgcaa ttctggaaga acgtgattat
    35461 caggaagacg gcgaagtgat tacaggctac atttccgaga aaaataaatg gaggttagaa
    35521 gaattttatg actgatatta aaactttggc tctaaagtat ggaggttata caagtctgga
    35581 caaggtctat ctggatcagc ttctagctgg taaaacagag caggagcagt taacacttat
    35641 tacacctccg ccaagtgttg ttaatgccta ctttgcagaa ctctatcaga aaaagagtcc
    35701 tcaggctgcg acggattatt ttgcagaact cagtcaggaa ctgaatcttt acaatactga
    35761 gccaagtttc accctagaaa ataagccttt tattcggctt aatctgtctg gtaaatcctt
    35821 tggtttttgt tatgagagtg acggccttgg tcggattttc tctgaaaatg aggagaaaat
    35881 ctcggatgac ttgctctttg aaattgcgca aattttcccc catcaattag tctttgaaga
    35941 gtctggtaag atttacatga agcctgtcga ggacgaggaa gttgtcagcc tagaaagtct
    36001 cacagctttg actgatttgg aaagattggc tgatggtcga aaacgtctca aaggctacag
    36061 ccaagaggat ttattgcaag aagctgctgc tttttctggc aaacgctatt tccgatcgga
    36121 aaaccgcaca gccatgttat atattgatta attagaaagt atcgaatgga tattcaattt
    36181 ttaggaacgg gggctggtca gccctctaaa gcccgcaacg tttcaagtct cgccctgaaa
    36241 cttttggatg agattaacga agtttggctc tttgactgtg gagaaggtac gcaaaatcgc
    36301 attctggaaa ccacaattcg accacgtaag gtcagcaaaa tctttattac ccatctgcat
    36361 ggagaccaca tttttggttt gccaggtttc ctttctagcc gtgcctttca ggccaatgaa
    36421 gagcagacag atttggaaat ctacggacct caaggaatca agtcatttgt cttaaccagc
    36481 cttcgtgtgt caggttctcg tctgccctac cgcattcatt tccatgagtt tgaccaagat
    36541 tctctgggta aaattcttga aaccgataaa ttcactgtgt atgcagagga gctggaccac
    36601 actattttct gtgttggcta tcgtgtcatg caaaaggatc tagaagggac gctggatgct
    36661 aaaaaactca aggctgctgg tgttccgttc ggcccgcttt ttggtaaaat caaaaacggc
    36721 caggatcttg ttttggaaga cggaactgaa atcaaggcag cagactatat ctcagcgcca
    36781 cgtccaggta agattatcac tattttagga gacactcgaa aaacggatgc cagtgtgcgt
    36841 ctggctgtca atgcagatgt cctagttcat gagtccactt atggcaaggg tgatgaaaaa
    36901 attgctcgta accatggtca ctcaactaat atgcaagctg cacaagtagc ggtagaagca
    36961 ggtgccaaac gcctcctact caaccatatc agtgcccgtt tcctctcaaa agatataagc
    37021 aaactcaaga aagacgctgc cacaattttt gaaaatgtcc atgtggtcaa agacttggaa
    37081 gaagtggaaa tctagcagtc acagaaagga taagtatgcc tactattctc attaccggag
    37141 ctagcggtgg tctagctcaa gaaatggtca aactcctgcc caatgaccaa ctcatcttgc
    37201 ttggtagaaa taaggaaaaa ttagcccaac tctacggaaa ttattcccat gcagaattga
    37261 ttgaaattga tattaccgac gattcagccc tagaagctct ggtaactgat ctttatctcc
    37321 gctatggcaa gattgatgtc ttgattaaca acgctggtta cgggattttt gagggatttg
    37381 accaaattgc tgataaagac attcaccaga tgtttgaggt caataccttt gccctgatga
    37441 atctgtctcg tcaccttgcg gctcgtatga aggaaagcag caaagggcat atcatcaaca
    37501 tcgtcagcat ggcaggtcta atagctactg gcaagtctag tctttactca gcgaccaagt
    37561 ttgcggctat tggtttttca aatgctctgc gactcgaact tatgccctat ggagtctatg
    37621 tgacaacagt caatccaggt ccaatccgaa caggattttt tgaccaagct gacccagatg
    37681 gaacttatct taaatcggtt gaccgcttcc tcttagaggc agatgcagtg gctaaaaaga
    37741 ttgtcaagat tataggcaaa aataaacgag aactcaatct cccgattttg ttgaacctag
    37801 cccataagtt ttatactctc tttcccaagc tagctgataa gttggcaggg gaaactttta
    37861 attataagta aaaagaacca atgtgcaggt tgttgctagc ctacatattg gttcttatca
    37921 tttctcaact atcaaactga acttcttcta gtagatagtc gataaagcgt tcgcccatct
    37981 tagataggct ggttttctca tgctggatat agaccagctc aatcgggtca tcaatatcca
    38041 gtgggataga aacaatattg tctccgttta ggttgctgtt caaaatccct gtcgcaatgg
    38101 tataaccatc caaaccaatc aagagattaa agagggtggc acggtcactg accacaatgg
    38161 attttttgtg gtgttcttga gaaagaatct cttctgaaaa gtagaaggag ttgtgcgtcc
    38221 cttggtcata gctgaggtaa gggaaattct ccaaatcaga cagtttcacc ttgtctttct
    38281 ttgccagagg gttggtcttg ctgacaaaga tatgcggttg cgctgtgaag agatggtggg
    38341 ctagcaggtg attgtcatcc agcatcttgg ttaaaacatc acggttgtaa ctgtttaaga
    38401 agaggacccc gacctcactg cggaagttct tgacgtcgtc gataatctcc caagtccgag
    38461 tttcacgaag gaagagttcg tatttctcca tatcgctttt cttgagcaaa gagacaaagg
    38521 cattgaccac aaaggcatag tgttgagacg aaacgctaaa gagttcgcgg tgggcgacag
    38581 gatttttata gcgttcctcc agaagctggg tctgctcgac aacctgacgg gcataagaga
    38641 gaaactccat cccatcacgg gtcaaggtga ttcccttggg attgcggata aagatctcaa
    38701 tgcccatttc attttccaaa tctcgcactg cattggagag acttggctga gtgataaaga
    38761 gttgcttggc tgcctcattc atggagccag tttcgacgat tttgataata taatgtaatt
    38821 gttgaattct catgttttta ttgtaccata cttgccttag aatcgctaaa gaagatagga
    38881 aaataaggag cattgtgtga gtctcttctt gaaaaaaaca caaaattttg ctagaatgag
    38941 tcttatgaaa acattctatg atgtgcagca attcctcaaa cgatttggta ttattgttta
    39001 catgggaaaa cgcttatatg atattgaact gatgaagttg gaactatctc ggatttacga
    39061 tgcagggttg atggataaat tagactatct agaggcagaa gcagttcttc gcagagagca
    39121 caaggtagaa ttggattata ttgagaaaaa tggagaaaag aactaatggt tacttggatt
    39181 ttgtgggcac ttatactagc aatgttggcg tggatgggct ttaactatct tcgtattcgc
    39241 cgtgcggcta aaattgtgga caatgaggag tttgaagcct tgattcgtac gggtcaattg
    39301 attgatttgc gcgacccagc agaattccac agaaaacata tccttggtgc acgcaatatt
    39361 ccttcaagtc agttgaaaac tagtcttgca gcccttcgta aagataaacc tgtccttctc
    39421 tacgaaaacc aacgtgcgca acgagttaca aatgcagctc tttacttgaa aaaacaaggt
    39481 ttttctgaga tttatatcct ttcttatggc ttggattctt ggaaagggaa agtgaagact
    39541 agctaacctt atttccaaat tagtcgaatg ataggatgaa gatattgttt tatagtataa
    39601 ttaatttgta taaaatttaa ggagttctta gaacatgaaa gaaaagaaga aaaatccact
    39661 ttttgtgggt atcttgtcga ttattcttgg tttgttattt ccaattgtag gcctgatttt
    39721 gggtatcata ggattggtct tagctatttc ataccaaaaa gagtcacaat tagactataa
    39781 aatagaaaag attcttaata tcttaggaat tgtgatttct gtagttaact ggattgtagc
    39841 aatcgcctta atttttcgat aaataaaaga aaaaagcttt agttttaaag ctttttttgt
    39901 tttatcgact catctctaaa tagtttttaa tgatttgtaa ctctttttgg ttcaaagggc
    39961 ggtagttacc ttctgctaaa tctgggttca atgtgaagtc cccaaattgg attctcttga
    40021 ggctagtcac cttaatacca accgagagga acattttctt gatttgatga aattttcctt
    40081 ctgaaatggt gatagaggct tgactgatgg agggacttgc agatagaatc tctagttttg
    40141 cgggtttaca gacagtacca tctaaaaaga caattccctt ttgaaaggct tggatatggt
    40201 caggtgttag aagtccatta acctcaactt gataagtctt atcgacatga tattggggat
    40261 ggaggagttg gaagcccaag ggaccgttat cggtcaagag aaggagtcct gttgtatctc
    40321 ggtccagtcg gccgacggca tagagcttgt cagactggat gtcagatgga agcaggtcca
    40381 tgacggtcgg aagttccttg tctttgttgg ctgtaacgac accagcaggt ttatgaagca
    40441 taagataggt gtgttcatag ccttgaatga ttcgatcctg aaaaaggagt tcttgtagtc
    40501 ctgtatcgat attttgagct agggagcggg ctgggcaacc atcgactaga atttcccctc
    40561 tgaggagtgc ttgtttcatg gcctttcggc tgattttttc ttgagctaat aaattatcta
    40621 aacgcatact gtgcctatct tatcataagt cgcttgcttt gaaaaggctt gacgtgaaaa
    40681 gaaaagcgga gtgaaaacat ttacacttgc ttgagttatg ttatttattt gaaattatgg
    40741 tataatcgtt cagttagaaa ataaattttg aatattatag aggaaatcat gacaaaatta
    40801 agagaagata tccgtaacat tgcgattatc gcccacgttg accacggtaa aacaaccctc
    40861 gttgacgaat tattgaaaca atcagaaacg cttgatgcac gtactgaatt ggcagagcgt
    40921 gctatggact caaacgatat cgaaaaagag cgtgggatta ccatccttgc taaaaatact
    40981 gccgttgctt acaacggaac tcgtatcaac attatggaca caccaggaca cgcggacttt
    41041 ggtggagaag ttgagcgtat catgaaaatg gttgacggtg ttgtcttggt cgtagatgcc
    41101 tatgaaggaa ccatgccaca aactcgtttc gtattgaaaa aagccttgga acaagacctt
    41161 gtcccaatcg tggttgttaa caaaatcgat aagccatcag ctcgtccagt agaagtagtg
    41221 gatgaagtct tggaactttt catcgagctt ggtgcagatg acgaccagct tgatttccca
    41281 gtggtttatg cttcagcgat caacggaact tcttcattgt cagatgatcc agctgaccaa
    41341 gaagcgacta tggcaccaat ctttgacacg attatcgacc atatcccagc tccagtagat
    41401 aactcagatg agcctttgca gttccaagtg tcgcttttgg actacaatga cttcgttgga
    41461 cgtatcggta tcggtcgtgt cttccgtggt acagttaagg ttggggacca agttaccctt
    41521 tctaaacttg acggtacaac taaaaacttc cgtgttacaa aactcttcgg tttctttggt
    41581 ttggaacgtc gtgaaatcca agaagccaaa gcgggtgact tgattgccgt ttcaggtatg
    41641 gaagacatct ttgtcggtga aaccatcact ccgacagatg cagtagaagc tcttccaatc
    41701 ctacacatcg atgagccaac tcttcaaatg actttcttgg tcaacaactc accatttgct
    41761 ggtaaagaag gtaaatgggt aacctctcgt aaggtggaag aacgcttgca ggcagaattg
    41821 caaacagacg tttcccttcg tgttgaccca actgattcac cagataaatg gactgtttca
    41881 ggacgtggag aattgcactt gtcaatcctt atcgaaacaa tgcgtcgtga gggctatgaa
    41941 cttcaagtat ctcgtccaga agttatcgta aaagaaatcg acggtgttaa atgtgaacca
    42001 tttgaacgtg tacaaatcga cactccagaa gaataccaag ggtctgttat ccaaagcctt
    42061 tctgaacgta aaggtgaaat gttggatatg atttcaactg gtaatggtca aactcgtttg
    42121 gtcttccttg ttccagcgcg tggtttgatt ggatactcaa ctgagttctt gtcaatgact
    42181 cgtggttacg gtatcatgaa ccataccttc gaccaatact tgccattgat tccaggggaa
    42241 attggtggac gtcaccgtgg tgcccttgtt tctatcgatg ctggtaaggc tacaacttac
    42301 tcaatcatgt ctatcgaaga acgtggtacg atctttgtca acccaggtac tgaggtttat
    42361 gaaggaatga tcatcggtga aaactctcgt gaaaatgact tgacagttaa catcacgaag
    42421 gcaaaacaaa tgaccaacgt tcgttcagct actaaggacc aaacagctgt tatcaagacg
    42481 cctcgtatct tgacacttga agagtctctt gagttcttga acgacgatga gtacatggaa
    42541 gtaacgcctg agtctatccg tttgcgtaaa caaatcctta acaaagcaga gcgtgagaaa
    42601 gctaacaaga agaaaaaatc agctgaataa gagctagaaa gagagaaaga tggtctattt
    42661 agtcctagga attttactgc tcctactcta tgtatttgcg acaccagaaa gcattaaagg
    42721 gactgtcaat atcgtcgcta tggtatgtat tttagtggca ctcttgattt tattggttct
    42781 atcttttctg aaaatttttc aattaccaac agaaatattc ctagcaatag ccatgttgat
    42841 cctagcttac tttagtgtta gagacatcac actcatgcca gtcaaaaaaa gtaaaagaag
    42901 ataaaaaaga gagtttcggc tctctttttg ctaggaattt tacaatagtt tgaattgctt
    42961 tttagttaac accatctctt ttacttgtat agtatgaatg ggaaaaactt gaataaaatt
    43021 cgttaatggc atctatttta tatttggtta gtactggttg catattattt tgaaataaaa
    43081 ctactatata atattattca cagaggtaat atagtaaaat atctaaaaaa ttcgattttt
    43141 tccttgacaa caaataataa aaatgttatt cttatcacat aagaaatcgg tttcaaaaaa
    43201 gagagaggag gatttatttt gttgcattgt tgctcagggt gtgctttttt tgaaagaaaa
    43261 aataaaatga aaacgaaaaa acatagatta cttgctctag ctcttatttc aagctttaca
    43321 ttattgggag ctgcatcagc tgctgtacaa tatccagatg gaggagtatg gacatatgga
    43381 gaaggttcag gaggtggttg ggctttttca aattactatc atggtaaaaa atatcattat
    43441 tcttctgttg taagtaaatg ggatagtcat tcagataaag gatcagcacc tgcagggaaa
    43501 acttcagagg cttggatttg gactaaattt ggggaacaag tatcatttta ctatgactat
    43561 gactaatatt tagttttctt agataattcc ccttgtaaga aattacaggg ggaattttgt
    43621 ttacaaggag tctactatga agaaactatt catattacta tcaacttttt ttctcagctt
    43681 cttctttgct tggattattg tcttacgtgc gccacaatat ttatatgcaa gctatgattc
    43741 cgttacttta cttcgtgtca aaaaagaggc tcaggaaccg actcgtgagg tatttgaaca
    43801 ggaattggag aagtttgtaa actcagaaca gagtttaata gctaggagaa ttgtagaacc
    43861 gagtaaggat gggacgactc actttactta tgcaacttat ggtcagggaa cattaccaaa
    43921 acaattccaa gaagctagcc aagaaagtcg tgaacgtagt gatccgctaa atagttatct
    43981 ccttttatca ggctccttga caaaagaaaa gctagctgat aaattaggag atttaggtta
    44041 taaagcaatt gctgaccgaa agacaccgcc ctattttctt gcttttcgaa tattactaaa
    44101 tccccttatt ttaattagtt tagcaatatt tggcttatct ttctttgctt tagtgattat
    44161 cactcggatt aaggaaatga gagcagcagg tataaaactc ttttctggtc agactctctt
    44221 atccattatg gggcattctt tatctactga tattaagtgg ctccttctat cagccctcct
    44281 ttccttccta ggtgggggag tcgttctttt tagtcaaggt ttgttttatc ctatcttgtt
    44341 agccacctat ggttttggga ttagtttcta tctgttgttt ttattggcga tttcaatttt
    44401 actaatgctc ctttatctaa tgagtttgag ttacaaagca ttagttcccg ttattaaggg
    44461 aagattaccc cttaaacgcc tgatgatttt aaccctattg tgtcagttgg ttgctgtctt
    44521 tacagtggga tacgctgtta agacaggttt gacgtcttac caacgattga aagaacttga
    44581 aatttcaaaa caagcatggc atgacagagt agactattat caaatttctt ttggcttagg
    44641 tgacagagta aatgatacag aaaatcagaa taagtggtat gaattttcca aagaagcagt
    44701 tgaaaaagaa caggctctat ttgtaaaaga gaatctcatt cattttgcaa atcctcaagg
    44761 aaaaaatgaa aacggggaaa cactggatac ctatagtcca gatgctaatg ttctctatgt
    44821 gagtccaagt tatttagaca aggaaaatgt ggctgtaaat gatgagacta gacagaaact
    44881 agctcatctt caaaaagggg aatttggact cttattacca gaatctcttc gttcacagga
    44941 agcagaactt aagaaagttt ttgaagaacg tttgaactat tacggaaaat caagcgagga
    45001 taaagacgct cctttagagt atgaaatgag agcgattgtt agctatcttc caacaggaca
    45061 aaaacgcttt gtttataata acggtgaaag tccagtatct attcagtact taaccgatcc
    45121 gattttagtt gtatttactc caacatctac aggtgatagt ttcatttcaa aatatgtttg
    45181 gtctatcaat gctggaaaac aactctttat caaaggatat gagagtgggc tagaactctt
    45241 aaagaaagct ggaatttatg agcaagtatc ctatcttaaa gaaggaagaa gtgtttatct
    45301 aactcgttat aatgaagttc aaactgaaac agcaacttta atcttaggag ctattgttgg
    45361 gatagccagt tccttattac tcttttattc tgtcaatctt ctatatttcg agcaattccg
    45421 ccgagatatc ttgattaaac gaatttcagg tttacgattt tttgaaacac atgctcagta
    45481 tatggttagc caatttgcca gttttgtatt tggtgctagt ttctttattt taagcagtcg
    45541 agacttggtg attggcttgc tcactttatt cgtctttcta gctagtgcag ttttgacgct
    45601 ttaccgtcaa gcacagaaag aatctcgtgt ttctatgaca attatgaaag gaaaatagga
    45661 tgattgaact aaagaatata tctaaaaaat ttggaagccg tcagctattt tcagatacaa
    45721 atcttcattt tgaaggtggg aaaatttatg ccttaatcgg tacaagtggc tgtggtaaga
    45781 caacactctt gaatatgatt ggacgattag agccatatga caaagggcaa atcatctatg
    45841 atggcacttc tcttaaggac atcaagtctt ctgttttctt tagagattac ttgggatact
    45901 tatttcaaga ttttggctta attgaaagcc aaaccgtcaa agagaatctc aatctgggtt
    45961 tagttggtaa aaagttgaag gaaaaagaga aaatctcttt gatgaaacaa gctctaaacc
    46021 gtgtaaacct ctcttatttg gatttgaagc aacctatatt tgagttatca ggaggagaag
    46081 cacaacgtgt tgcattagcg aagataattt taaaggatcc gcctttgatt cttgcagatg
    46141 aaccaaccgc ttccttagac cccaaaaact ctgaggaatt actttccatc ctagaatctt
    46201 taaaaaatcc gaatcggacc attattattg cgacccacaa tcctctgatt tgggagcaag
    46261 tggatcaggt cattcgagtt accgatttat cacatagatg atatggtaag attcagttag
    46321 aagaaagagt cacaaacaca ctttgtggct tttttatttc cataaaaatg gtaaaatagt
    46381 aggagtagaa atggagttcg agacatgaaa gtaatagatc aatttaaaaa taagaaagtt
    46441 cttgttttag gtttggccaa gtctggtgaa tctgcggctc gtttgttgga caagttaggt
    46501 gccattgtga cagtaaatga tgggaaacca ttcgaggaca atccagctgc ccaatgtttg
    46561 ctggaagaag ggatcaaggt cattacaggt ggccatcctt tggaactctt ggatgaagag
    46621 tttgccctca tggtaaaaaa tccaggtatc ccctacagca atcccatgat tgaaaaggct
    46681 ttggccaagg gaattccagt cttgactgag gtggaattgg cttatttgat ttcagaagca
    46741 ccgattattg gtatcacagg atcgaacggt aagacaacca caacgactat gattggggaa
    46801 gttttgactg ctgctgggca acatggtctt ttatcaggga atatcggcta tcctgccagt
    46861 caggttgctc aaatagcgac agacaagaac acgcttgtta tggaactttc ttctttccaa
    46921 ctcatgggtg ttcaagaatt ccatcctgag attgcggtta ttactaacct tatgccaact
    46981 catatcgatt atcatggatt atttgaggaa tatgtagcag ccaagtggaa tatccagaac
    47041 aagatgacag cagctgattt ccttgtcttg aactttaatc aagacttggt aaaagacttg
    47101 gcttccaaga cagaagccac tgttgtacca ttttcaacac ttgaaaaggt tgatggagct
    47161 tatctggaag atggtcaact ctacttccgt ggtgaagtag tcatggcagc gaatgaaatc
    47221 ggtgttccag gtagccacaa tgtggaaaat gcccttgcga ctattgctgt agccaagctt
    47281 cgtggtgtgg acaatcaaac catcaaggaa actctttcag ccttcggtgg tgtcaaacac
    47341 cgtctccagt ttgtggatga catcaagggt gttaaattct ataacgacag taaatcaact
    47401 aatatcttgg ctactcaaaa agccttgtca ggatttgaca acagcaaggt cgtcttgatt
    47461 gcaggtggtt tggaccgtgg caatgagttt gacgaattgg tgccagatat tactggactc
    47521 aagaagatgg tcatcctggg tcaatctgca gaacgtgtca aacgggcagc agacaaggct
    47581 ggtgtcgctt atgtggaggc gacagatatt gcagatgcga cccgcaaggc ctatgagctt
    47641 gcgactcaag gagatgtggt tcttcttagt cctgccaatg ccagctggga tatgtatgct
    47701 aactttgaag tacgtggcga cctctttatc gacacagtag cggagttaaa agaataaaat
    47761 atgaaaaaaa ttgtctttac aggtgggggg acggttggac acgttaccct caatcttttg
    47821 ttaatgccca agttcatcga agatggttgg gaagtccact atatcgggga caagcgtggt
    47881 atcgaacacc aagaaatcct taagtcaggt ttggatgtca ctttccactc cattgcgact
    47941 ggaaaattgc gtcgctattt ctcttggcaa aatatgctgg acgtcttcaa agtttgctgg
    48001 ggaatcgtcc aatcgctctt tatcatgttg cgacttcgtc cacagaccct tttttcaaag
    48061 gggggctttg tctcagtacc gcctgttatc gctgcgcgtg tgtcaggagt gcctgtcttt
    48121 attcacgaat ctgacctgtc tatgggcttg gccaataaaa tcgcctataa atttgcgact
    48181 aagatgtatt caacctttga gcaagcttcg agtttgtcta aggttgagca tgtgggagca
    48241 gtgaccaagg tttcagatca aaaaaatcca gaaccagatg aattggtgga tattcaaagc
    48301 cactttaatc ataaattgcc gactgtattg tttgttggcg gttctgcagg tgctcgtgtc
    48361 tttaaccaat tggtgacaga ccataagaaa gaactaacag agcgctacaa tattatcaat
    48421 ctaactggag attctagcct gaatgagttg agccaaaatc tttttcgtgt tgactatgtg
    48481 accgatctct atcaaccctt gatggaattg gctgatattg ttgtgacacg aggtggtgcc
    48541 aatacgattt ttgagctctt ggcgatagca aaattgcatg tcattgtgcc gcttggtcgt
    48601 gaagctagtc gtggtgacca gcttgaaaat gcagcttact ttgtaaaaaa aggctatgca
    48661 gaagaccttc aagaaagcga tttgaccttg gatagtttgg aagagaagct ttctcactta
    48721 ctaagtcaca aggaagatta ccaagctaag atgaaggctt ctaaggaatt gaaatctcta
    48781 gcagattttt atcaattgtt gaaaaaagat ttatcataag gaaagtaaat gtcaaaagat
    48841 aagaaaaatg aggacaaaga aatcctcgaa gaattgaaag agttatcaga atggcagaaa
    48901 cgaaaccaag aatatctaaa aaagaaggct gaagaagagg cggctctagc tgaggagaag
    48961 gaaaaggaaa gacaagctcg aatgggagaa gaatctgaga agtcagagga caaacaggac
    49021 caggagagtg aaacagacca ggaagattca gaatcagcta aggaagagtc tgaagaaaaa
    49081 gtagcatcct cagaggctga caaagagaaa gaagagaaag aagaaccaga gtctaaagag
    49141 aaggaggaac aggataaaaa gctttctaaa aaggctacaa aggaaaaacc agccaaagca
    49201 aagattcctg gtatccatat cttgcgagca ttcacgattt tatttccaag tctgctttta
    49261 ttgattgtct ctgcctactt gctcagtcct tatgcgacca tgaaagatat tcgtgttgag
    49321 ggaacggtgc aaactacagc tgatgatatt cgacaggctt caggcattca ggattcggat
    49381 tatacgatta accttctgct agacaaggca aaatatgaaa agcagattaa gtctaactat
    49441 tgggttgaat cagctcaact tgtctatcaa tttccaacta agttcactat taaggtcaag
    49501 gaatatgata ttgtggccta ctatatttct ggtgaaaatc attatcctat tctttccagt
    49561 ggtcagcttg agactagttc tgtgagtctg aacagtttac cagaaactta tttatcagtt
    49621 ctctttaatg atagtgaaca aatcaaggtt tttgtctcag aacttgctca aattagccca
    49681 gaactcaagg cggctatcca aaaggtggaa ttagccccaa gcaaggtgac atccgattta
    49741 attcgattga ccatgaatga ttcggacgaa gtcttggttc ctctatctga aatgagtaag
    49801 aaactgccat attacagtaa gattaagcca caattgtcag aaccgagtgt ggtcgacatg
    49861 gaagctggaa tttacagtta cactgtggcg gataaattaa ttatggaggt tgaggaaaaa
    49921 gccaaacaag aggccaagga agctgagaaa aaacaagaag aagaacagaa aaaacaagag
    49981 gaagagagca atcgaaacca aacgacccag cgctcatcgc gtcgctaggt ttactttttc
    50041 tcttatagtt atttagtgac catgttttta cttgacaagt gctagtagaa ataatagaat
    50101 aatagaaaac ctttaaagca gtccagagag gcagctaagg ttagacggtg aaagggtgga
    50161 gactacccat ttttcgtgga accttgctgt tggcaggttc cttttttcgt ggcttctgtt
    50221 ggtcagactc tctcactagt aaaggtaaaa ggagaaacct atgcgagaac atcgtccaat
    50281 cattgctctt gattttccta gttttgaggc ggtcaaggaa tttttagctc ttttcccagc
    50341 agaagaaagc ctttatctca aggtagggat ggagctttat tacgcagcgg ggcctgagat
    50401 tgtgtcctac ttaaaaggtt tgggtcatag tgtctttttg gatctcaaac ttcatgacat
    50461 tcctaataca gtcaagtcag ccatgaaggt cttgtctcag cttggtgtcg atatgactaa
    50521 tgtccatgcg gctggtggtg tagagatgat gaaggcggcg cgtgaaggtc ttgggagtca
    50581 agccaaattg atcgctgtaa ctcagctcac atcaacgtca gaagctcaga tgcaggagtt
    50641 tcaaaatatc caaaccagtc tgcaagagtc tgtgattcac tatgccaaga agacagctga
    50701 agctggcttg gatggtgttg tttgctcggc tcaggaagta caagtcatca agcaggctac
    50761 caatccagat tttatctgtc tgacaccagg gattcgtcca gctggtgttg cagttggaga
    50821 tcaaaaacga gtcatgacac ctgctgatgc ctatcaaatc ggcagtgact atatcgtagt
    50881 gggacgtccc attacccaag ctgaggatcc tgttgcagct tatcatgcca tcaaggatga
    50941 atggacacag gactggaatt aaagaactag attagaaaaa taaaaggaga ataccatgac
    51001 acttgctaaa gatatcgcta gccacctctt gaaaatccaa gccgtttacc tcaaaccaga
    51061 ggaacccttc acttgggcat ctggtatcaa gtcaccgatt tacactgata atcgtgtgac
    51121 actagcctat ccagaaactc gtaccctaat tgaaaatggt tttgtggatg ctatcaaaga
    51181 agcctttcct gaagtagaag tgattgcagg aactgcaaca gcagggattc cacacggagc
    51241 cattattgct gataagatga acttgccttt tgcctacatc cgtagcaaac caaaagacca
    51301 cggagctggt aatcaaatcg aaggtcgcgt agctcaaggt caaaaaatgg tagtggttga
    51361 agaccttatt tcaacgggtg gttcagttct tgaagctgta gcagcagcca agcgagaagg
    51421 agcagatgta cttggagttg tagcgatttt cagctaccaa ttgccaaaag cagataagaa
    51481 ctttgcagat gctggtgtta aacttgtgac gctttcaaac tatagcgagc ttatccatct
    51541 agcccaagaa gaaggttaca tcacgccaga gggccttgat cttctaaaac gctttaaaga
    51601 agaccaagaa aattggcaag aaggttaggt cagtaagata aagagagacg aggctaccga
    51661 gtctctttta ccattttatt taaaatatga caatatttta aataaaataa ttgacaacgc
    51721 tttcttttat tgatataatg aaaatgtaat atgtatcaaa ttgatcaatc aactatcttg
    51781 tttatcactt cttaagagga cgatgtcatg aaaagaagaa aaatatattc cttttttgcg
    51841 tagttacaat tgcatctagt ttgtttctcc ctacagtttt agctagacag attggaaatt
    51901 atgatttaac gttgccgcgt tggggttcgg atacaactag tgagcttgag aaagaaaacg
    51961 cctctgctgg aattaataat agtgacagca ctggtggcgg taaaaggtta agtacctcta
    52021 ttcgtagcgc ctatagtggg tcagatatta ccccggtata ttcattgggg tctggctcta
    52081 ggattgtcat gtactataat ggaggtggtg acaattatat tggttctggt actagattag
    52141 ctatggcgcc acaatttgga aatcatgtaa gaattcatac ttcaggttct tggagtccag
    52201 attcttatta acttacttgt cagagtaagc cttaaagatg gttgattgtg ggtgtagcat
    52261 gaaaaaagaa tgctacaccc tatttttatt ataaggagga gtaaggatgg aatttttcat
    52321 ttgtaatctt gtacgagtcg ttcaatcacc tcgattttat atgtctttat ttttgaccct
    52381 tctttgcatg agtttaggaa atttccttgc tttcaatggt atttataaaa ttgaaggttt
    52441 atcgattttt tttgccgctt cttctattcg aggattttca ccgattagcc tagtagctgc
    52501 acttatctgt acactgccct attctagtca gataatagag gatgctgaga gtcattttct
    52561 aacagcacaa ttgtgccgaa tttctaaaaa gaggtatcta gctattgtag gtagtactgc
    52621 aattatttct tcttttctag tcttttttct cccctattta ttattattag gaattaatct
    52681 tttagtgact ccttatcagg aaatttatat tggagcttat agtggtgcct taaaagaatt
    52741 atttgattct aatcagttgc tctatagtct tgtgacgact ctttggtatg gagtttgggg
    52801 cgctgtgttc tctatttttg gactagctag tgctttgcta gtgaagaaaa aaataggagc
    52861 tattttcatc ccagttacct atatgatggt tggtggtatt ttttgggcta ttttagggct
    52921 atcttactta gaacctgtga caacattagc tttgggatat cagaaagata tcagtctttc
    52981 cttagttagt gggcatcttg cttttatttt atttgttagt tgtttggttg tttatggtac
    53041 attttttcta cattcagagg actatgtata atgaaacaat ttgttcaatt ttataaaaaa
    53101 gatttcttag cagtattggt ttattttata ttactgctat cctgtgtttt atctagtaca
    53161 gtatatttat tgcgctgtcg ccaatattca atccatccaa atgtattaga atggatctta
    53221 gttttacttc aagatatgac gactggagta tattgctttc cgttcacata tatattgttc
    53281 tttttttatt tgatgaataa ctattttaat aggttggagt gtcgcattcg tctgaaatca
    53341 attaagcact ttaccagttt tagtttcaaa ttagcagctc ttagtacggg gatttggacg
    53401 gcgattttat ttttattgat ttttctaatt gcatttagta atggttttag cttctctttg
    53461 gagataaagg aggttgattt tttaagagaa ttttatggta taagtattgc aaacaatgct
    53521 agtttcttta taggattttt tttctcttat atagcatact atttcttttt atccttactt
    53581 actattagca gtttttcttg gtttaaaaaa tcaaacatga gcttagtatt tctgtttact
    53641 tttttatttg tagaatcctt attctggatt tatcagttga acaatgggat aattggatta
    53701 ttgccaattt ttcagtatat ggtaaattcc aatccgtatg cattgattta ttggcttaca
    53761 ttactatcta tcataattcc attgactgta ttttctgttc atagaaactg gaggagagtg
    53821 taaaagttgg aaatgggaaa gttaagtagt cacatgtgga ggttgaatca gataatctat
    53881 accaagtact tttggggtta tgttcttttt tggatattga tttgtttagg attatggtat
    53941 tggttagaag gaaatgatag acttgttata gaaattttaa aagggcctaa tctgagtcaa
    54001 aactcttttt tagtcttatc tatatggttg cttcattggt ttattattca tacatttttt
    54061 ctagcagttg tatatcgtag aagagcatcc gatttcttta tggaagtgat tcgattttct
    54121 tctattaagc tctggattag gtatcagatt tggacctgtt ttctttatgg actcatttta
    54181 atcatggtaa aagttctagt gattcaattt atgttacagt taccaaactg ggatatagga
    54241 gttttgttta tagttgattc tttgaatgct tgtgtgttag tcttgttttg ctttatgtta
    54301 tacgcactag gagcgaatgt acaaatgaac tttgcttgcg ttagtttctt tttactcatg
    54361 attgtgtttg gtggtctatt tgtaggaaat cgaactaatt atctatttta tattttgaat
    54421 cgagggaatg gagatatagg acgagattta tttcttcagt tgctattttt agtctttctt
    54481 tttaaaagta ttttctattt cactcgtcaa aagaggaggt ttatagaatg aatgaaataa
    54541 tcatattaaa aaatattgag ttgaaattaa aaaaaacatg tgtttttcaa aaccttaatt
    54601 ttagttgtaa acagggggaa attataggaa ttactggtgc gaatggctca gggaaaagtg
    54661 tattgtttaa attaatagct ggtttatata gtccgtctta tggagaagtg ttaatcaatg
    54721 gggaaaatat tgttcctgag agaaaaattc cagctaattt gggagctttg attgaagaac
    54781 ctggttttat aaattattat agtggcttta agaatttaca atatttggca agcatacgag
    54841 gagtagttgg taatcaggaa atcaatgata cactgaaaat agttggtcta tatgagcaaa
    54901 aagaccagaa agttaaaact tattcgctag gtatgaggaa aaagctaggg attgctcaag
    54961 caattatgga gaatccctct attcttttac tagatgaacc tatgaatgcc ttggataaat
    55021 caagtgtaga aaatatgaga acattgttta gaaagctctc tagtgaaaaa gggacaacaa
    55081 ttttgattgc tagtcatagt gaagaggata ttcgtatctt atgtgataaa gtatatgcaa
    55141 tagaagataa agtatgtaca ctgtgttcag attaaacatc ttagatagac tcaggatgtt
    55201 ataggtaaaa tcttaaaaag ggattggagc ttaaaatcca gtccctttta agagttaatg
    55261 gccaccttca acaaccaggt catctgcttt agcagcgtca ccgtaggttg ggtgaagtgt
    55321 tttttcatag gccttgtgga agaagttttc cttgcctaat ttttcaatat ctttattgat
    55381 gaagtctagc aattcttggt tgcctttttg aactgctgcc gcaatggtat cgggatcacc
    55441 gagggaagta attcctactt caaatccttt attttcaagt gcccaagcta gaacttccgt
    55501 attgtcagtt gaaaaggcat ctccacgtcc gtcaagaaga gcttggtaag agtcactgta
    55561 ttggtcgtat ttttggagtt tgatttctgg atgattcttt tcaaaataag tctcagcagt
    55621 cgttcctttt gtgacaatta aggttttacc ttcaagttgt ttgacgtctg taatgagacc
    55681 agtcttaggt gatacgacac ccagagaaac tttcatatat ggaagggcaa aatcaacttg
    55741 tttcttacgt tcgtcagtta ctgtaaagtt agcaagagta atatctacct tgtttgaaat
    55801 caagtattcc gcacggttgg cagcatcgac tgaaatgtat ttaaccttga caccaaggtc
    55861 ttgagctagt tggttcccta gttcaatatc gtagcgtagc cttggtaaga accatcattg
    55921 tcaacgtagc caaacggttt tttatctcca aacacggcga ttcgcagttc accgcttttt
    55981 tttgatttca tcgatagtgc gagctttggc agttgttttt ccagaggatg aaccagcgtt
    56041 tccacctgag ctacaagcag tgataaagat aagggcaaag gcaagtgcta aaacagttag
    56101 gagtggtttg aatagtttca taagaatctc ctttatagat atgagccaaa ttggctaaag
    56161 tcaaagacgt ttaaaaattc ctgggctcgt ttggtttgcg gattggtaaa gaaggcttga
    56221 gctgttcctt cttcagcgat tttcccttgg tcgaggaaga taatccggtc agcaatggct
    56281 tgggcaaact gcatttcgtg ggttactaaa atcatggtac ggccttcttg ggccaaatca
    56341 ttgataagtt ccagcacctc acgcaccatt tctggatcca gcgaagcagt cacctcgtca
    56401 aaaaggatga tttctggatg cattaggagg gcacggacaa ttgcaacacg ttgcttctgt
    56461 ccaccagata attgacgggc aaagctatgt tgtttatcca gcaaaccgac acgatctagt
    56521 aattgcaaag cttcttccgt tacttctttc ttgtcccatc cttgagtttt gatagggcct
    56581 aggatgaggt tttgtaagac atccagatgg ggaaagagtt cataacttta aaagaccatg
    56641 ccaatctttt ggcgaactag gtgaaaatct tttttatttt caacgataga ctgaccatcc
    56701 agaagaatgt ctccaccttg aatactttct aagccgttga ggcaacgaag gagggtactt
    56761 ttcccacaac cagatggccc taggatgaca acaacttccc cttttttgat ttctagagaa
    56821 agtccttgga ggatgggatt gtctccgaag gattttttta gttccttgat ttctaagata
    56881 gtttcagaca tttagtttct ccaatgtttt tctaagtgag tggatagttt ggaaataggg
    56941 tagcaaactg cgaaatataa gattagaatg gttccataaa tccaaaatga agcagttggg
    57001 atggtcaggc gattgctatc gatgatttgt tgtccaactt tggtcacttc cacaacccca
    57061 atcaaaacaa ctaatgaagt ggttttaatc atccgagtga caagattgat agcctgcggt
    57121 agcagtcttc ttaagacttg tgggatgatg atgtggtagt aaagttgaac attagtcaag
    57181 tcgagtgcct atccactttc aaactgatgt ttagggagag aagtgatagc tccacgtacc
    57241 aagtctccca tttcagctgt tccccagagg gtaaaaatga taatagctga agtctcacct
    57301 gagatattga tattaaagtt tcgagccaag ccaaagtaaa cgatgaagag tagcaccagc
    57361 tggggcatga tacggataaa ttccagatac aatcgtgtta aaaatcgtat gattctagaa
    57421 tgggaggtca tgatgattcc catgactgtt ccgaacatca tggataagag gacagacagg
    57481 atggatatcc caatcgtaac gcccaacccc tgtaagattc tcaggagatt atttccttga
    57541 aagagtactt ggattcccga atcctgcatg gcgggtcctc ctttctatcc agctaaagac
    57601 cagtgagatg ggtagcagca tgatcagata agcaactacc aacatagcta gcgcaatgtc
    57661 tgtctcatag tagagaccaa tcaaatcctt ggcgacgtac atgaggtcgg ccaaagccac
    57721 tgctgagaaa acagaggttt ccttgataag gaaaatgaca ttggcactaa aggaggggag
    57781 tgccaccgct gttgcttgcg gaagaaccac atagcgaaag acctgtagag gtgtcagacc
    57841 aatagcgagg ccaatctcct gctgggtttg actgatggct tccagcccac ttcggaaaga
    57901 ttctgccata taggatcctc ctaaaaagac aagcccaagc gttgcacaga cttctgaaga
    57961 taggacaatc ccgattcggg gaagaccgaa gtagagaaag aagagttgaa tcaaaagggg
    58021 cgtattacgt gacaattcaa tgtaggctgt cgctacttgc gccaaaacag ggattcgata
    58081 atgtcggatg atactaacga ttaaaccgag cagaaaggat cccaaaattc cccaaactgc
    58141 aatatgcaag gtcagaaaga atgccttttg atatagtggt agatattgtt caacaatgga
    58201 ccaatccaaa aatagaacct cccatctaga aataatacag ttattgtagc acttaaaatc
    58261 ttctttggat aatatctatt ttttattgcc gttataagga ttttttacca tagacataaa
    58321 atttctgaaa tttccaaaca aaatatttga aaagttttga aaaaaagtta agatattttt
    58381 gtaatataca aagtaaacgc ttacttatta aagaggacag tttatgtcat acaaaacaag
    58441 caatgcagaa ggtcatgtag atttcatcaa tacctatgat ttggagacaa tggcgcaaca
    58501 agttattcct aaagcagcat ttggctatat cgctagtggg gcggaagata ctttcgcttc
    58561 tttccagtga ttttagcgtc aggttctttt tagtttttaa agattatccg tgaatttctt
    58621 acttatttat gataaaatgg gagtatcgca aaaaatgact catcgtattc aattttgagt
    58681 aaaactagga ggatcccatg tctacagaac atatggaaga actaaatgac cagcagatcg
    58741 ttcgccgtga aaaaatggct gcgctccgcg aacaaggaat cgatcctttc ggaaaacgtt
    58801 ttgaacgtac tgcaaattca caagaattaa aagataaata tgccaacctc gataaagaac
    58861 aattacacga taaaaacgaa acagctacta tcgcaggacg cttggtaacc aaacgtggta
    58921 aaggtaaagt ggggtttgcc caccttcaag accgcgaagg ccagattcag atctatgttc
    58981 gtaaggatgc tgtcggtgaa gaaaactacg aaatcttcaa aaaagcagac cttggtgact
    59041 tccttggtgt cgaaggtgaa gtgatgcgta cggatatggg agaactctct atcaaggcaa
    59101 cccacatcac acacttgtct aaggctcttc gtcctcttcc tgagaaattc catggtttga
    59161 cagacgttga aacaatttac cgtaaacgtt accttgactt gatttctaac cgtgaaagct
    59221 ttgaacgttt tgtcactcgt tcaaaaatca tctctgaaat ccgtcgttac cttgaccaaa
    59281 aaggattcct tgaagtggaa acacctgttc ttcacaacga agccggtggt gctgctgccc
    59341 gtccatttat cacccaccac aatgcccaaa acattgacat ggtgcttcgt atcgcgactg
    59401 agcttcactt aaaacgcctt atcgtgggtg gtatggaacg tgtctatgaa attgggcgta
    59461 tcttccgtaa cgaaggaatg gatgctactc ataaccctga gttcacttct atcgaagttt
    59521 accaagctta tgcagacttc caagatatca tggacttgac ggaaggcatt atccaacatg
    59581 ctgctaaatc agttaagggc gatggcccag tcaactatca aggtactgaa atcaagatta
    59641 acgaaccatt taagcgtgtt catatggtgg atgctatcag agaaattact ggtgtcgatt
    59701 tctggcaaga catgactttg gaagaagcta aagctatcgc tgctgagaag aaagttccag
    59761 ttgagaaaca ctacactgag gttggtcaca tcatcaatgc cttctttgaa gagtttgttg
    59821 aagaaacttt aatccaacca acctttgtct atggacatcc agtagctgta tctccactcg
    59881 ctaagaaaaa tcctgaagac caacgcttta ctgaccgttt cgagctcttt atcatgacta
    59941 aggagtacgg taatgccttt actgagctca acgacccaat cgaccaactt agccgttttg
    60001 aagcccaagc taaagccaaa gaacttggtg atgatgaagc gacaggaatc gactatgact
    60061 acattgaagc tcttgaatac ggtatgccac caacaggtgg tttgggaatc ggtatcgacc
    60121 gtctctgcat gctcctcact gatacaacaa ctatccgtga tgtattgctc ttcccaacaa
    60181 tgaaataaat tcttatcctc tggctcttac cagaggattt ttttattcaa aaagagactg
    60241 aatttaagga gaaaatgaag tgtagtgtat tgaaattgaa atagtacact ttgatttcta
    60301 agacattgtt agaaattggt ttaaattccc taatcaattt gtgcatgttt tatttcattt
    60361 tacgatagta cgctgaaact tttcaaaaag tactagaaat tgacttggat tccccaattg
    60421 atttgttcag attcactata aataaaaaat taataagtgg gataggaagt tagcgtcaac
    60481 taggatagta tcttgcttaa acagtatata tgggactgat ataagtccat aggtcctatt
    60541 agaggatgtt ctggtgtctt attcacttgt tttttatagt attagtagat agaatcagca
    60601 aataaaaaag tagttcaaat gcctggcagc aaaaaatctc aacgattcac ttaatataga
    60661 ctaaggttta gagtttaagg aaagtagggc tagtatattg tatgaaaaaa taagatggtt
    60721 tttaagcaaa actcttgaaa atgattgaaa aaagagttat tatagttgta tagtaaaaag
    60781 caaacgctta cttaatcgag gaggacagtt tatgtcatac aaaacaagca atgcagaagg
    60841 tcatgtagac tttatcaata cctatgattt ggagccaatg gcgcaacaag ttattcctaa
    60901 agcagcattt ggctatatcg ctagtggggc ggaagatact ttcactttaa gagagaatat
    60961 ccgcgccttt aaccacaaac tcatcgttcc tcatacactt tgcgatgttg aaaatccaag
    61021 tacagagatt gaatttgcag gtgaaaaact atcttcgcca atcattatgg cacctgttgc
    61081 ggctcataaa ttggcaaatg aacaggggga agtggcgact gcgcgtggtg tgcatgagtt
    61141 tggttctctt tatacaacca gttcttactc tactgttgac cttccagaga tttctgaagc
    61201 ccttcaaggg acacctcatt ggtttcaatt ttactttagt aaggatgacg gtatcaaccg
    61261 ccacatcatg gaccgtgtga aggatgaagg ttataaagcg attgtcttga cggcagatgc
    61321 tactgtaggg gggaatcgtg aagtggataa gcgtaatggt tttgtcttcc cagttggcat
    61381 gccgattgtt gaagaatacc tgccagaagg tgctggtaaa tcaatggact ttgtttacaa
    61441 atcagctaaa caacgcttgt ctccacgcga tgtagaattt atcgctgaat actctggtct
    61501 tcctgtgtat gtcaagggac cacaatgccg tgaggacgtt gaacgttcgc ttgctgcagg
    61561 agcttctggt atctgggtaa ccaaccacgg tggtcgtcaa atcgacggtg gaccagctgc
    61621 ctttgactcg cttcaagaag tggcagaagc agttgataga cgtgtgccga ttgtctttga
    61681 ctctggtgtt cgtcgtggtc aacacgtctt taaagccttg gcttcaggag cagacttggt
    61741 agctattggt cgcccggtta tttatggctt ggctctcggt ggtagtgtcg gtgtgcgtca
    61801 agtctttgaa cacttgaatg cggaattgaa gacagttatg caattgtctg gagctcagac
    61861 cattgaagat gtcaaacact ttaagctccg tcacaatcca tacaacccaa ccttcccagt
    61921 tgaccctcgt gacttaaaat tgtattgata aaacagattg cctccactga atgtggaggt
    61981 ttttcttcgt gtattggaag aataaatcgc tatcgaaaac catagtaaaa tggaataaaa
    62041 acaggacaaa tcaatcagga tatttaaatc gatttctaac aatgttttag aagtagaggg
    62101 gtactattct agtttcaatc tactatatat aaagatattt ttcggttaaa tatcttgcta
    62161 aggctttcat tttttgctat actggttcag taattaaata atagagacat ttggggtgct
    62221 ttaggctgag ataataccca ttgaacctga tacagttaag actggcgaag ggaaatgtga
    62281 acagtttttt cgtatggtga aatgaacggt ctaatcttgt aagtcaactc taattcttga
    62341 ttgtaattgg agttttttgt ttatataaac tggataggct tgtttagtta gctctctgca
    62401 aatactctcg atgtgtttta aaaggatcaa gtggaattac gattttgctt gatatttctt
    62461 ggtgttttac taattactaa caagtaaaga gaggagaagt aaatatggaa acacaagact
    62521 atgcatttca gccaggtttg actgttggag aattattaaa aagcagtcag aaggattggc
    62581 aggctgcaat caatcatcgt tttgttaagg aactttttgc ggggacaatt gagaataagg
    62641 tcttaaagga ctatctgatt caagattatc acttctttga tgccttctta tccatgctgg
    62701 gtgcctgcgt agctcacgca gataaacttg aatccaagct tcgttttgcc aagcaactag
    62761 gctttcttga agcagatgaa gatggttatt tccaaaaggc ttttaaagag ttaaaagtag
    62821 cagagaatga ctatctagaa gtgactttgc accctgtaac aaaagccttt caggatctaa
    62881 tgtattcggc agtggcttca tcagactatg cccatctttt ggttatgctg gtcattgcag
    62941 aaggtctcta tttagactgg ggttctaaag atttggctct acctgaagtc tatattcatt
    63001 cggaatggat caatctccac agaggtcctt tctttgcaga gtgggttcaa tttctggttg
    63061 acgaactcaa tcgtgtcggt aaaaatcgag aagatttgac agaacttcag caacgctgga
    63121 atcaagcagt cgctttagaa ttagcttttt ttgatattgg ttacgatgtc tagagaaggc
    63181 tcatgatatt tacaaatttg atgaggtaat actcttcgaa aatctcttca aaccacgtca
    63241 gtttcacctt gccgtaggta tggttactga cttcgtcagt tctatccaca acctcaaaac
    63301 agtgttttga gctgacttcg tcagtcttat ctacaggttc aaagcagtgt tttgagcaat
    63361 ctgcggttag cttcctagtt tgctctttga ttttcattga gtataaatca ttcaacgtaa
    63421 atgaaaaaaa tttcttaacg aaagatagag ataaatcgaa atcagtagat cgtataaagt
    63481 gaaaaggaag gatttcaata tgacaagttt aaaattatta aaaaaaaaag caccattggt
    63541 catttgtata accaatgatg tagtaaaaaa tttcacagca aatggattag tagcactggg
    63601 cgcctcacca gccatgagtg agtttccagc agatttagag gatttgttaa agtatgctgg
    63661 tggtttatta ataaacatag gaacattgac agatgaaaat tggaaattat accaagctgc
    63721 tctgaaaatt gcggagaaat ataatgtccc agcagtttta gatcctgtag cctgtggagc
    63781 aggagaatat agaaaaaaag tagcagatga tctaatcaac aattataaac tagcagcgat
    63841 tagaggaaat gctggcgaga ttgcctcttt agtaggaata gatgtggcat ctaaaggagt
    63901 agatagtgcg ggcgtagata atattgacga aattgctcta gcagcaaatg agaagttcaa
    63961 tattccaata gtagtaacag gtgaagtgga tgccattgct gttaatggag aagtggtaac
    64021 gattcataat ggtagtgcta tgatgccgaa agtcattggg acaggatgct tattaggagc
    64081 tgtagtagca agttttatcg gactggaaaa aggtcaagaa ttaaaatcat tagaaacagc
    64141 aatgttagtt tacaatatcg ctggagaaat ggcagaaaaa cgtccaaatg gacatcttcc
    64201 tgggacattt aaagttgaat ttataaatgc cttatacgag attacagatg aagatgtaaa
    64261 ggaattcaaa agagtgaagt aagatgtttc ataaagaatt actaaaacta tattttattt
    64321 gtggaacgac tacttgccaa ggaaaaaatc tatatacagt cgttgaggaa gccttaaaag
    64381 gtggtataac cttatttcaa tttcgagaaa aaggtgaggg tgctttagaa ggcttagaaa
    64441 aacttgagct agctatccaa attaaagaac tttgtaaaaa atacaatgtt ccatttatcg
    64501 ttaatgacga tatagattta gcaatggaaa ttgacgccga tggcgtacat gtaggtcaag
    64561 atgatattgg tgttgatgaa attagaaaat tgatgccaga taaaataatt ggtctttcta
    64621 taagaaacga agaagaattt caacaatcaa aagttgaata tgtagattat gtaggtgttg
    64681 ggcctgtatt tgatacccag tcaaaagatg atgctggtgg tgctataggt tatgaaggtc
    64741 ttgaattgat gagaaaacta ttgccacaaa tgcctttagt tgcaattggt gggatacaga
    64801 cgaaacatat taaagacatt ataaagacca atatggatgg cgtttcaatc atttcggcaa
    64861 tatcgtatgc aaaaaatata gaaaaaactg ttcgggaaat gagtgaacaa tagatatcta
    64921 tccttggatt ctaagtaagt aggattttcc ttttttaaaa agctatgtcc agattcagct
    64981 tgaatggcta attcatcaaa caggtcattt gttttttgca aaagaaagat ctgctgtctt
    65041 tgtgagtgca aggctgtatt tccagttcaa tttcttgaac tagtataaaa tgtttgttat
    65101 aataatcaca taattaaata ataaagacat ttggggtgct ttaggctgag atgataccca
    65161 ttgaacctga tacagttaag actggcgaag ggaaatgtga aatgtttttt tcgtatgtcg
    65221 aaaagaactg tctaatcttg taagctgaac tctaattcgt atctgtaatt agagtttttt
    65281 cttttacgaa actggatgaa gatgatacag tagattgaaa taagatgcga acaaatcaat
    65341 tagaaaattc aaattaattt ctagaaatat tttagtgttc ttgtgtactg ttctaaattc
    65401 agtctgctat acaaagtatt taggtcggtc ttcttgagtg ccccactttt ctttaaaaaa
    65461 aggagttttt tatgttgaaa aaatggcagt taaaagatgt tatcttgctt gctttcttgt
    65521 ctatcttttt tggtggggtt ttcgttggtt caggatatgt gtataatatt ctcagtctac
    65581 tcttaacacc tcttggtttg caggcctttg ccaatgaaat cctcttcggt ctctggtgta
    65641 tggctgcgcc cattgctgcc atctttgttc cgagagtcgg aagtgcaacg attggagaag
    65701 tgctagctgc gcttgctgaa gtcctttatg gtagccaatt tggtctagga gctcttttgt
    65761 ctggcttggt tcaaggtttg ggaagtgaat ttggttttat cgtaactaag aatcgctatg
    65821 aaagttggct ctctctaact gctaatagta ttgggattac gcttgttagc tttgtctatg
    65881 aatacattaa gttaggttac tacgcctttt cccttccgtt tgtcctttcc ttgcttgtgg
    65941 tacgttttat ttctgtttat ttcttctgta ccatcttggt tcgtgccatt gtcaaactct
    66001 atcatcagtt tgcaactgga ggaaaagcat agatgggtct ggaactacga gcgattcagt
    66061 ccccaatttt ctctgagccg tttgatttta cttttcatgc gcaagccttt accttgttag
    66121 ttgggagcag tggttcagga aaatccagcc tctttcaaat gattgcccaa gtcagttctc
    66181 ttccctatag tggtcaagtc ctgatagatg ggagcgaggt cagtcagctt tctatcatcg
    66241 cacgtgtcca gaaggttggc attctcttgc aaaatctcaa tcatcaattt accatggaga
    66301 acttgtttga ggagttgatt ttcaccttgg agaatatcgg ctatcacctt caggaaattg
    66361 attctaaaat agcagaggtt gtccagcaat gtcgttgcga ggcaatctta caccgtccca
    66421 ttcatcacct atcaggtggg gaaaagcaaa aagcagcgct ggctgtcctc tttgccatga
    66481 atcctagggt ctatctcttg gatgagccct tcgcttccat tgaccgcaag agtagaatcg
    66541 agatattgga gattctaaaa gagttggctc ttgatgggaa gacagtcatt ttgtgcgacc
    66601 atgatttatc tgactataaa gcctatatcg actatatggt tgagctaaga gacggaaaac
    66661 taagggaagt gtttcaaatc ccttcctatg agatgacaca ggttgcttca aaggaagttg
    66721 cttctagccc ggaactattc catatggata gaacgacttg tgagtttgga aatcgctccc
    66781 tcttttcaat tgctgatttc acattctatc aagggatttc ctgtatcctg ggtgacaatg
    66841 gtgtcgggaa atcaaccctc tttcgctcta ttcttcaatt tcaaaagtat aaggggcgca
    66901 ttgcatggaa ggggacagtc ctgaaaaaga aaaagagttt gtaccgtgat ctgacgggtg
    66961 ttgttcagga agctgagaag cagtttatcc gagtcagtct gcgagaggag cttcaattag
    67021 atggacctga ttctgaaaga aatcagcgga tttttcaagc tttacgatat tttgatttgg
    67081 agcaggcagt cgataagagt ccctatcaat taagtggtgg tcagcaaaaa attcttcagc
    67141 tcttgaccat cttgaccagt aaggcttccg tgatcttgct agatgaacct tttgcaggtt
    67201 tggatgatag agcctgccat tatttttgca agtggattgt ggaggagagg aatcaaggaa
    67261 gaagttttct gctcattagt catcgtttag accctttgat ttctgtggtt gattattgga
    67321 ttgagatgac tagtcagggt cttcggcatg tgaaagaagt gaccattacc aaaccactta
    67381 catctcagag tagcaatacc caaggggagg tgagatagta tggtcaaagt agcaacccag
    67441 acaccgatta tcagtctctt cttgctgatt ttatccttgg aaacatcttt cattccttcg
    67501 attgctctga atctttcggt agtcgcattt tgtattctct ttatgctcta ttaccgtcga
    67561 tttaaaatgt tagcttggat gatcatactt gccattttac catcttttgc caactactgg
    67621 gcagttcagt tacacggaga tgcttcacag gcagtcatgc ttggaacgag ggcctttgtg
    67681 acagtttgta tcggccttgt ctttgtttcc tctatttcac taaaagagct tctcttgtac
    67741 ttggctcaaa aggggctatc acgctcttgg tcctatgcct tgattgtggt attcaattct
    67801 tttcctctca ttcagcaaga aatcaagtcc ctcaaagaag cttgcctatt acgtggtcaa
    67861 gaactacatt tttggtcgcc cttgatttac agtaaggttc tgatgacagt ctttaggtgg
    67921 cgccatcttt acctgagagc tctatctgct cacggatatg acgaacatgc acagttgaag
    67981 aatagctatc ggacttttta tattcctaaa aaaacaaaat taatctacct gcttttcttt
    68041 ttattgcttc aaaccagtct atttttataa aggagttatt atggaattta cagatattgc
    68101 gatggaatta tccaagaaag cttggcaggc ttcctttcat catcccttta ttttacaatt
    68161 acaagagggg aatttagaac ctgccatttt ccgctattac ctgattcagg atgcctacta
    68221 tctgaaggcc ttctcagaaa tctatcatct tttggctgat aagacttcaa accaagagat
    68281 gaaaagactc ttgaaacaaa atgctcaggg tttagtggag ggtgagttat ttattcgcca
    68341 acaatttttc aaggaattgg aaatcagcga ccaggaaatg gagcaacatc caatcgctcc
    68401 aacctgttat cattacattt ctcatattta taggcaattt gcagagccga acttagccat
    68461 cgcttttgca agcttgcttc cttgtccttg gttataccat gatataggca aatcacttaa
    68521 tcttaaacca tcaccaaatc ctctctatca acaatggatt gaaacttata ttacggatga
    68581 gttagagcaa cagatcagag aggagggagc actggtcaat cagctctatc gagaaagtga
    68641 tgagacagat aagcaaaaaa tgctagatgc cttccacatc agtgttcata tggaagccaa
    68701 gttttgggag atggcttacc aacaccagac atggaagagc gatttacagt ctttagaaaa
    68761 aggagaagaa tagaaacatg agaaagcacc aactacaagt tcacaaattg accattttat
    68821 ctatgatgac tgcccttgat gtagtcctta cacctatctt tcggattgag ggaatggcac
    68881 cgatgtccag tgtagtcaat attctagcgg gaatcatgat gggacctgtt tatgccttgg
    68941 ccatggctac agtgacagcc tttatccgta tgacgactca agggattccg cctttagctc
    69001 tcacaggagc gacttttgga gcccttctag caggtctctt ttataagtac ggtcgaaaat
    69061 tttacttttc tgccttggga gaaattgtgg gaacaggtat tattggttct attgtttcct
    69121 atcctgttat ggtactcttt acaggatcag ctgctaagct tagctggttt atctacacgc
    69181 ctcgattttt cggagcaacc ttgattggta cagcgatttc ctttattgcc tttcgatttt
    69241 taatcaagca ggaattcttt aaaaaagtgc agggatattt ctttagtgaa aggatagact
    69301 gatgcaggaa tttacaaatc cctttcctat aggctctagt tccctcattc actgtatgac
    69361 caatgagatt tcttgtgaga tgctggcaaa tgggattttg gctctgggat gcaaacctgt
    69421 catggcagat gatccccgtg aggttcttga ttttactaag caaagtcagg ctctcttcat
    69481 caatttgggg catttgtcag ctgagaagga gaaagcaatc cgtatagcag cttcttatgc
    69541 agctcaagtt tgtctcccaa tggtagtaga tgcggttggc gtaacagctt catccattcg
    69601 taagagctta gtcagagacc ttttagacta tagacctacg gtccttaaag gaaacatgtc
    69661 agaaattcga agtcttgttg gattaaagca ccacggcgtt ggggtcgatg cgagtgctaa
    69721 agatcaagaa acggaggatt tgcttcaagt cttgaaagac tggtgtcaga cctatcatgg
    69781 tatgtctttc ttagtcacag gtcccaagga cctcgtcgtt tcgaaaaatc aggtcgctgt
    69841 actgggaaat ggctgtgcag aattagactg gataacaggg acaggagatt tggttggagc
    69901 cttaacagcc gtttttctca gccaaggaaa gactggtttt gaagcttctt gcttagcagt
    69961 ctcttatctc aatatcgctg ctgagaaaat agttgttcaa ggaatgggat tggaagaatt
    70021 tcgttaccaa gtactcaatc agctttcgct cctaagaaga gatgaaaatt ggctagatac
    70081 catcaaagga gaggtttatg aatagagaag cacttagact atatctggta accaatcgct
    70141 atcaagattc cgtggaaagc tttcttgcaa aagttgagac ggcctgccgt tcaggggtta
    70201 ccatagtcca attgcgagaa aaaaatctca caaccaatca atattatcaa ctggcaaaac
    70261 aagtcaagga aataacagat gcttatcagg tacccttgat aatcgatgat cggttggatg
    70321 tttgtcttgc ggttgatgca gcaggtctgc atatcggaga tgatgaatta ccagtttcgg
    70381 tagctcgcaa agtcttgggt cctgaaaaaa tcctcggtgt caccgctaaa acggttaaaa
    70441 gagctctgga agcggagaaa tcaggtgcag attacttggg tacaggagcc attttcccaa
    70501 ccaccaccaa ggaaaatgcg cccattactc tgatatcgac cttgaaaaca atttgccaaa
    70561 cggttgccat tccagtagtt gctattggag gcttgacttc ggagaatatt gatcagctta
    70621 tgggcactgg catagctggt gtagctgttg tacgtgattt gatgcaagca gaagatattg
    70681 aggcaaaaac gcaagccttt ttaacaaagt tgcatgacat tctttcctaa ttaatactca
    70741 atgaaaatca aagagtaaac tagaaagcta gtcgcaggtt gctcaaagta ctgccttgag
    70801 gttttagata agactgacga agtcagctca aaacagtgtt ttgaggttgc agatggaagc
    70861 tgacgtagtt tgaagagatt ttcgaagagt ataaaaactc tctaattccc ttaaagtggg
    70921 aactagagag tttttttctt aatctttaaa agttgtatgg ttgactggac cagaaccatg
    70981 accgagttga ggggcatctt gaatagcttt tgtgataaag gccttggcct tatcaactgc
    71041 ctggtaaaga ctcttgccct tggctagttc agcagtaatc actgcagcaa aggtacatcc
    71101 agtaccatgg gtgtgacagg tttgaattcg tgggctttcc cagacaaatt gttcattctt
    71161 ggtaaagagg aaatctttag caccgccttt gagatgtccg cctttgataa ccacagactg
    71221 aggaccaaat tcttttaaaa tcaggcgacc agcacgctgc atgtcttcgg ggtcatggat
    71281 tgaaaaacca acaatctctt ctgcttcagg aagatttggc gtaataatag ttgctagagg
    71341 tagtaagttt gttttgagat agtctctagc atttgagcca atcaaggcat ctccacttgt
    71401 agcaaccata acaggatcaa ggacataggg acaatccagt tttttaagat agggttggat
    71461 gatttccatg atttcagtag tagccaacat tccagttttt acagcctgag gtggaatatc
    71521 agaaaagaca ctctccaatt gggctttcaa catttgagga gaaacgtgct cgattagctg
    71581 aacacctctg gtattttgag cgacaagact ggttacaaca gccattccat agacatctct
    71641 cgcttggaat gactttaaat ctgccataat gccagcacca ccactagggt cagtccctgc
    71701 aatggtcaaa gcaacgggta aataagtcat ctaaaacctc ccaaccaact gaagtttgta
    71761 ttcttaagaa caagctagtc tgttttagaa aggcaataga agactgctag tccccattat
    71821 catttccact tccatcagct agcattacct agattgagtc agagggatct aacagtcgtt
    71881 aatctcagct ttacgcaccc ctagtggttg ttttcttttt tctttagtat agcatatttt
    71941 tattgtttat atagtaatat ttgactgcaa atcgtttttc aaatgattaa aattctattt
    72001 ttcgaagaaa atattatttc tataattgac aaatgtagat tttaagagta tactgatgag
    72061 tgtaattgac aaatgtagat tttggaggta tggtaatgca gatttcagat gcagaatggc
    72121 aggtcatgaa gattatttgg atgcaggggg agcagaccag tacagatttg attagggttt
    72181 tggcagagcg gtttgactgg tccaagtcca cggttcagac acttttggct cgtctggttg
    72241 agaaagagtg tttgactcgg aaaaaagaag gcaagtcctt tgtttattca gcccttttaa
    72301 ctctagacca aagtcgggat ttacttgtcc aagatatcaa agacaaggtt tgttcccgta
    72361 ggattaggaa tttgttggct gacttgattg tagaatgtga atttactcag actgacttgg
    72421 aagacttgga agctgtgatt tcagagaaga aatcaagtgc tgtaacagaa gtaagatgta
    72481 attgtatgta aaggagacgt catgttaaat agtattgtaa ccattatttg tattgccctt
    72541 atcgcgttta tcttgttttg gtttttcaaa aagcctgaaa aatctggaca aaaagcccag
    72601 caaaaaaacg gataccaaga gattcgagtg gaagtcatgg gaggctatac tcctgagttg
    72661 attgtcctca agaaatcagt gccagcacgc attgtctttg accgcaagga tccttcacca
    72721 tgtctggatc aaattgtttt tccagatttt ggtgtacatg cgaacctgcc aatgggggaa
    72781 gagtatgtag tggaaatcac gcctgaacag gctggagagt ttggctttgc ttgtggtatg
    72841 aacatgatgc acggcaagat gattgtagag taggtggaga ctatgacaga aattgtgaaa
    72901 gcaagcttag aaaatggcat tcaaaaaatc cgtatccgag ctgaaaaagg ctatcatcca
    72961 gcccatatcc agcttcaaaa gggaattcca gctgagatta cctttcatcg tgctactcct
    73021 tcaaactgtt ataaggaaat tctgtttgaa gaagaaggta tcttggaacc aatcggcgta
    73081 gatgaggaga aagtcattcg ttttacgcct caagaattag ggcgacatga attttcttgt
    73141 ggcatgaaga tgcaaaaggg aagctataca gtcgttgaga agactcgaaa atctctatct
    73201 ctcctgcaac gtttttggat tactagtatc tttactgtgc ctcttgtgat tctcatgatt
    73261 gggatgttga caggtagcat tagtcatcaa gtcatgcatt ggggaacctt tctagcaaca
    73321 acgcctatta tgttagttgc aggtaagcca tatatccaga gtgcttgggc cagttttaaa
    73381 aagcacaatg ccaacatgga taccttggtt gcgctgggaa ctctagtggc ttatttctat
    73441 agcctagttg ctctctttgc tggtctccct gtttacttcg aaagtgctgg atttatcctc
    73501 tttttcgttc ttttgggagc agtttttgag gaaaaaatga gaaaaaatac gtcccaagct
    73561 gtggagaaat tactggactt gcaagctaaa accgcagaag tcttgagtga tgatagttat
    73621 gtccaagttc ctttggaaca agtcaaggta ggcgacctga ttcgagtgcg tcccggtgaa
    73681 aagattgctg ttgatggtgt cgtagtagaa ggtgtctcta gtattgacga atccatggtg
    73741 acaggtgaga gtctgcctgt ggacaagaca gttggagata ctgtcattgg ctcaaccatc
    73801 aatcatagtg gaacgcttgt ctttagagca gaaaaagttg gctcagagac tgttttggct
    73861 cagattgtgg attttgtgaa gaaagctcag acaagtcgtg cgccgattca agacttgacg
    73921 gataagattt cagggatttt tgtcccagta gttgtcattt taggaatcat gaccttttgg
    73981 gtttggttcg tcttgctcag ggatagtgtg gttgtgcttg gagctagctt tgtgtcctct
    74041 cttctctacg gagtggcggt tttgattatc gcctgtcctt gtgccttggg acttgcaaca
    74101 ccgacagccc ttatggtggg gacaggacgt agtgccaaga tgggggttct cctcaaaaat
    74161 ggaactgtct tacaggaaat ccagaaagtt caaacccttg tctttgataa gaccgggact
    74221 ttgacggaag ggaaacctgt ggtaacagat gtcatcggcg acgaagtaga agtgtttagg
    74281 ttggcagcct ccttggaaga tgcttctcaa cacccactgg ctgaggctat cgttaagcga
    74341 gcgagtgaag ctggacttga gtttcaaact gttgaaaatt ttcagacctt gcacgggaaa
    74401 ggtgtttcag ggcgaatcaa tggaaaacaa gttttacttg gaaatgctaa aatgctggat
    74461 ggtatggata tttctaatac ttatcaagat aaactagaag aactagaaaa agaagctaag
    74521 acagttgtgt tcttagctgt tgacaatgaa atcaaaggct tgcttgcttt gcaagatatt
    74581 cctaaggaaa atgctaagct agccatcagt cagctaaaaa aacgtggtct ccgaacagtc
    74641 atgctgacag gagacaatgc tggtgtggcg cgtgctattg cagatcaaat cggaattgaa
    74701 gaggtcattg caggcgtctt gccagaagaa aaagcccatg aaatccataa actgcaacag
    74761 tcagggaaag tagcctttgt tggggacggt atcaatgacg ctcctgccct tagtgtagca
    74821 gatgtgggga ttgctatggg agctggaaca gatatcgcca tcgagtcagc agatttggtg
    74881 ttgacaacca ataatctttt aggagtggtt cgtgcctttg atatgagtaa gaaaaccttt
    74941 catcgaattc tactcaatct tttctgggct tttatctaca atgttgtcgg aattccgatt
    75001 gcagcaggag tcttttcagg tgttggactg gctctcaacc cagaattggc aggtctagcc
    75061 atggccttta gttctgtatc tgttctgacc agttcccttc tgttaaattt tagtaaaata
    75121 gactaaaagt aatgactaga tttctttgtt ataaaacaaa aatgacagaa ctttcaaaac
    75181 tgtattagaa tagagaatag agagttttga gcagattttt agaaaagtca gcataaatat
    75241 gatacagtgg aatagtaaaa atttggagaa cgtttccaat tctatgtaat cgtattctcc
    75301 aaatctaaaa aaattgaagg agagttatca ttatgactca agggaaaatt actgcatctg
    75361 cagcaatgct taacgtattg aaaacatggg gcgtagatac aatctacggt atcccatcag
    75421 gaacactcag ctcattgatg gacgctttgg ctgaagacaa agatatccgc ttcttacaag
    75481 ttcgccacga agagacaggt gctcttgcag cggttatgca agctaaattc ggcggctcaa
    75541 tcggggttgc agttggttca ggtggtccag gtgcgactca cttgattaac ggtgtttacg
    75601 atgcagctat ggataacact ccattcctag cgatccttgg atcacgtcca gttaacgaat
    75661 tgaacatgga tgctttccaa gagcttaacc aaaacccaat gtacaacggt atcgctgttt
    75721 acaacaaacg tgtagcttac gctgagcaat tgccaaaagt aattgacgaa gcctgccgtg
    75781 ctgcaatttc taaaaaaggt ccagctgttg ttgaaattcc agtaaacttc ggtttccaag
    75841 aaatcgacga aaactcatac tacggttcag gttcatacga acgctcattc atcgctcctg
    75901 ctttgaacga agttgaaatc gacaaagctg ttgaaatctt gaacaatgct gaacgcccag
    75961 ttatctatgc tggatttggt ggtgttaaag ctggtgaagt gattactgaa ttgtcacgta
    76021 aaatcaaagc accaatcatc acaactggta aaaactttga agctttcgaa tggaactatg
    76081 aaggtttgac aggttctgct taccgtgttg gttggaaacc agccaacgaa gtggtctttg
    76141 aagcagacac agttcttttc cttggttcaa acttcccatt tgctgaagtt tacgaagcat
    76201 tcaagaacac tgaaaaattc atccaagtcg atatcgaccc ttacaaactt ggtaaacgtc
    76261 atgcccttga cgcttcaatc cttggtgatg ctggtcaagc agctaaagct atccttgaca
    76321 aagtaaaccc agttgaatca actccatggt ggcgtgcaaa cgttaagaac aaccaaaact
    76381 ggcgtgatta catgaacaaa ctcgaaggta aaactgaggg tgaattgcaa ttgtatcaag
    76441 tttacaatgc aatcaacaaa catgctgatc aagacgctat ctactcaatc gacgtaggta
    76501 acactactca aacatctact cgtcaccttc acatgacacc taagaacatg tggcgtacat
    76561 ctccactctt tgcgacaatg ggtattgccc ttcctggtgg tatcgctgct aagaaagaca
    76621 atccagatcg ccaagtatgg aacatcatgg gtgatggagc attcaacatg tgctacccag
    76681 acgttatcac aaacgttcaa tacgaccttc cagttatcaa ccttgtcttc tcaaatgctg
    76741 agtacggctt catcaagaac aaatacgaag atacaaacaa acacttgttt ggtgtagact
    76801 tcacaaacgc tgactacgct aaaattgcgg aagctcaagg agctgttgga ttcacagttg
    76861 accgtatcga agacatcgat gcagttgttg cagaagctgt taaattgaac aaagaaggta
    76921 aaactgttgt catcgatgct cgcatcactc aacaccgtcc acttccagta gaagtacttg
    76981 aattggatcc aaaacttcac tcagaagaag ctatcaaagc cttcaaggaa aaatacgaag
    77041 cagaagaact cgtaccattc cgtctcttct tggaagaaga aggattgcaa tcacgcgcaa
    77101 ttaaataatt cctctcgccg aaaatcaaat atgaaacttg tagactttat tctttgattt
    77161 tcatagagca gaactttaaa ag
//
LOCUS       DBERMM010000005        76306 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.005, whole genome shotgun sequence.
ACCESSION   DBERMM010000005 DBERMM010000000
VERSION     DBERMM010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 76306)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 76306)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..76306
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.005"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            145..309
                     /locus_tag="ACL8AS_000434"
     CDS             145..309
                     /locus_tag="ACL8AS_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HGS1228355.1"
                     /translation="MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVI
                     TVVSFFTGRK"
     gene            393..959
                     /gene="amaP"
                     /locus_tag="ACL8AS_000435"
     CDS             393..959
                     /gene="amaP"
                     /locus_tag="ACL8AS_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="HGS1228356.1"
                     /translation="MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNS
                     VVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFV
                     RSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFG
                     IERQVKLEVAVKNYQPKPQNKKTVSRVK"
     gene            971..1141
                     /locus_tag="ACL8AS_000436"
     CDS             971..1141
                     /locus_tag="ACL8AS_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2273 domain-containing protein"
                     /protein_id="HGS1228357.1"
                     /translation="MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVA
                     AGLYIEKNYIDK"
     gene            1180..1788
                     /locus_tag="ACL8AS_000437"
     CDS             1180..1788
                     /locus_tag="ACL8AS_000437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HGS1228358.1"
                     /translation="MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLEN
                     VSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSE
                     IREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQ
                     FEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN"
     gene            1819..2022
                     /locus_tag="ACL8AS_000438"
     CDS             1819..2022
                     /locus_tag="ACL8AS_000438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HGS1228359.1"
                     /translation="MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVA
                     EDAKDAVEGAVEGVKNMLSGDDK"
     gene            complement(2132..2425)
                     /locus_tag="ACL8AS_000439"
     CDS             complement(2132..2425)
                     /locus_tag="ACL8AS_000439"
                     /inference="COORDINATES: protein motif:HMM:NF025126.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HGS1228360.1"
                     /translation="MNVDCDYEPESAPQKGLYMNERYQCLKTKEYQALLSSKGRQIFA
                     KRKIDMKSVFGQIKVCLGYKRCHLRGKRQVRIDMGFVLMANNLLKYNKRKRQN"
     gene            2650..2895
                     /locus_tag="ACL8AS_000440"
     CDS             2650..2895
                     /locus_tag="ACL8AS_000440"
                     /inference="COORDINATES: protein motif:HMM:NF033563.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HGS1228361.1"
                     /translation="MAESIQGWLAQFLVNLFKSITFDCGKEFSKWKDISNHHDSESFF
                     ANLGCSRQRCLNEHSNRLLRCHDLPKQTDFNEVSQEF"
     gene            complement(3173..3943)
                     /locus_tag="ACL8AS_000441"
     CDS             complement(3173..3943)
                     /locus_tag="ACL8AS_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HGS1228362.1"
                     /translation="MVEIIYFLIIIIASGLGSISGMGGGIIIKPLMDSFGYHSVSDIA
                     FYSSFSVFIMAIISTIKRFSQSKEIKWRLIFTVSFSSVLGGFLGHLIFQVLLSQLSVR
                     LVSIVQMILLFVMLLVSFVLTDFKKTYQFDKIGFYMICGLLLGLISSFLGIGGGPLNV
                     SLLMVFFSISIKEATMYSLAIIFFSQLSHLATIVVVTGLNQYHLAPVPVIFLASICGG
                     VLGTVVSKVLPENWVRYCFKGMLFFVMGMTLYNLFHIL"
     gene            complement(3958..4584)
                     /locus_tag="ACL8AS_000442"
                     /pseudo
     CDS             complement(3958..4584)
                     /locus_tag="ACL8AS_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016388867.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="SUMF1/EgtB/PvdO family nonheme iron enzyme"
     gene            complement(4574..5092)
                     /locus_tag="ACL8AS_000443"
                     /pseudo
     CDS             complement(4574..5092)
                     /locus_tag="ACL8AS_000443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095003.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
     gene            complement(5102..5419)
                     /locus_tag="ACL8AS_000444"
     CDS             complement(5102..5419)
                     /locus_tag="ACL8AS_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HGS1228363.1"
                     /translation="MDESNLESVMGLIMYGGEAKSNAMEAIQAAKKGDFSKANRRLAD
                     ANAALLQAHKAQTEMLTREAQGEKTSISLLMVHAQDHLMTSLTFVDLAKEVVEVYERF
                     EKN"
     gene            complement(5436..5753)
                     /locus_tag="ACL8AS_000445"
     CDS             complement(5436..5753)
                     /locus_tag="ACL8AS_000445"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001151647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1228364.1"
                     /translation="MAKVTIMLACAAGMSTSLLVTKMQKAAEDKGLDAEIFAVPAPEA
                     EEIVATKEVNVLLLGPQVRYLLGDFQEKLKDRQIPVAVIPMTDYGMMNGSKVLDLAES
                     LLD"
     gene            complement(5768..6664)
                     /locus_tag="ACL8AS_000446"
     CDS             complement(5768..6664)
                     /locus_tag="ACL8AS_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="haloacid dehalogenase-like hydrolase"
                     /protein_id="HGS1228365.1"
                     /translation="MKRLISANPSEILQMNAEELKQSILASEGRVVLSENVVTRETFV
                     GDITNSEIARAFGADMILLNCVDVFEPKIYALDSSGDDVIHRLHQLVACPIGVNLEPI
                     DPSAKMLEETQEIVAGRVASVETLKRIEELGFDFVCLTGNPGTGVSNQEIIKAVQSAK
                     ENFSGLIIAGKMHGAGVNEPVAELSVAEQLLEAGADVILVPAVGTVPAFHDQELREVV
                     DLVHSKGGLVLSAIGTSQETSDTDTIKEIALRNKICGVDIQHIGDAGYGGLATVDNIY
                     ALSKAIRGVRHTVSRLARSVNR"
     gene            complement(6667..7929)
                     /locus_tag="ACL8AS_000447"
     CDS             complement(6667..7929)
                     /locus_tag="ACL8AS_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HGS1228366.1"
                     /translation="MEKLLQEKLLPVAARLGNNKALVSIRDGITLTIPLLLIGSLLMV
                     IASFPIPGWEKYLGDIGVADYLWKGVDSSFGLLGLVASFGIAYFMARQYKVDGIPAGI
                     VSLSSFITVTPFIRGEAGAGMPTAFMASKGLFVAMILGLINGYIYQWFINHNIQIKMP
                     DGVPPAVSKSFSAIIPGAVTIVGWLIVYATLDKLSLPNLHEIAQVALGGPLGLLGNNV
                     IGLLILIFLNSSFWFVGLHGGNVVNAVMKPLWLANLDANKVAYQTGETLPNIFTSVFM
                     DNFVFIGGGGATIGLVLALGYLAHKKKASKQLKTLAPITVIPGLFNINEPAMFGVPIV
                     LNILLLVPFILAPMFNLLVAWGAMASGLVPLTYTDPGWTMPPVISGLLATGSISGSLL
                     QIVLIVLDVLLYLPFVIAIEKRFKLLED"
     gene            8209..9387
                     /locus_tag="ACL8AS_000448"
     CDS             8209..9387
                     /locus_tag="ACL8AS_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HGS1228367.1"
                     /translation="MTLSKKQLQLRAKILETVYTLGPISRIEIATKTGITPATTSSIT
                     NDLIKENILLELGEDEHDTSVGRKKILLDIQAKRFYYIGCELSEKHFTFALGDNLGNI
                     LKEEKEIVTKQLIQEKGNQLINQTLKQFLNNCSDYEIEAIGIALPGRYLDNYKITTNN
                     PLWQHIDLEMIQSHFDKPLFFSNNVNCMAIGKRLFSRQQNDPNFAYFHFARGMHCSYI
                     YDGNIYGKGNLMIGEIGHTVVSSEGEECSCGRKGCLQTFAGESWLIKKSKILYHQSPY
                     SLLPSLVKNADDIDIQVILTAYQLGDTGIITLIHQALLYLSQTILNISMMIDSQKIYL
                     HSPLLTNQHIIQKLYSEMNYKPKLLYNRLPEVIIEPYNDFTAAHSAIALCLYHTILHS
                     "
     gene            complement(9615..10061)
                     /locus_tag="ACL8AS_000449"
     CDS             complement(9615..10061)
                     /locus_tag="ACL8AS_000449"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000155432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228368.1"
                     /translation="MTIRFEEKVSTENAQFVCQWSNSLGKSFQEQWMGPRIPFLLTLQ
                     ALEGVFSIFDEQEFVGFIQKIRLEDSNLHIGRFFINPQKQEQDLGSQALRKFVSLAFE
                     NEDIDSISLNVFEANQRVQNLYQKEGFEIVQMVEAPVRKYSRLKLE"
     gene            10131..10790
                     /locus_tag="ACL8AS_000450"
     CDS             10131..10790
                     /locus_tag="ACL8AS_000450"
                     /EC_number="3.4.23.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="A24 family peptidase"
                     /protein_id="HGS1228369.1"
                     /translation="MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLR
                     PLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLGLLFLLYSWELLSLSKVILITAG
                     LTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
                     FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLL
                     V"
     gene            complement(10842..11993)
                     /locus_tag="ACL8AS_000451"
     CDS             complement(10842..11993)
                     /locus_tag="ACL8AS_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1228370.1"
                     /translation="MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKL
                     STKMHLANQFHVDLTYFEQEEESIRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLI
                     DYFESFIIIPNIIIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERS
                     GIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMN
                     EDGDRLEQEANYFASCFLLPKEEFLVKFEERVGKRVSNPDSYILLKSDLNVSIQALEY
                     RAFKLGLLTPKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSL
                     ATIMSKQSIRLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL"
     gene            complement(12008..12739)
                     /locus_tag="ACL8AS_000452"
     CDS             complement(12008..12739)
                     /locus_tag="ACL8AS_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000934015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228371.1"
                     /translation="MLNQDLFDSLEAQKIVDTLMKGQKDYVDERLEKRETMIVSNGYA
                     WTRPNHIDTAFASADLFEYKLQLAGQTWGYLEFETNTEKYGKVLLIIKGKKRLTNQFP
                     LVQKNKSGYLFEYAQMNTLYLNQHSSYKNDEDSHSFPIQMELVSDEMIQEIEQATKNS
                     NIEKFMILTYEADSENNIISVDVVMPDARTGQLHLIQDLSEYIQSSSYHFEEAKYQDI
                     PNFSELSETEDFEIIPRIEKQEGQK"
     gene            12968..13069
                     /locus_tag="ACL8AS_000453"
                     /pseudo
     CDS             12968..13069
                     /locus_tag="ACL8AS_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234126.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
     gene            complement(13041..13817)
                     /gene="trpA"
                     /locus_tag="ACL8AS_000454"
     CDS             complement(13041..13817)
                     /gene="trpA"
                     /locus_tag="ACL8AS_000454"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004834 - tryptophan synthase activity
                     [Evidence IEA];
                     GO_process: GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="HGS1228372.1"
                     /translation="MPKTLTKKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLE
                     DLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTY
                     FNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGI
                     ERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQA
                     DLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK"
     gene            complement(13810..15033)
                     /gene="trpB"
                     /locus_tag="ACL8AS_000455"
     CDS             complement(13810..15033)
                     /gene="trpB"
                     /locus_tag="ACL8AS_000455"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004834 - tryptophan synthase activity
                     [Evidence IEA];
                     GO_process: GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HGS1228373.1"
                     /translation="MAYQEPNKDGFYGKFGGRFVPETLMTAVLELEKAYRESQADPSF
                     QEELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLA
                     KRMGKKKIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQALNVFRMELLGAKV
                     EAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQ
                     QYRDLTGQNLPDALVACVGGGSNAIGLFHPFVEDESVAMYGAEAAGFGVDTEHHAATL
                     TKGRPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTD
                     EEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKELGPEKSMIVCLSGRGDKDVVQVK
                     DRLEADAAKKGEAHA"
     gene            complement(15011..15610)
                     /locus_tag="ACL8AS_000456"
     CDS             complement(15011..15610)
                     /locus_tag="ACL8AS_000456"
                     /EC_number="5.3.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="HGS1228374.1"
                     /translation="MTKVKICGLSTKEAVETAVSAGADYIGFVFAPSKRQVTLEEAAV
                     LAKLIPADVKKVGVFVSPSRVELLEAIDKVGLDLVQVHGQVADDLFENLPCASIQAVQ
                     VDGNGHVPNSQADYLLFDAPVAGSGQPFDWGQLDTTGLAQPFFIAGGLNEDNVVKAIQ
                     HFTPYAVDVSSGVETDGQKDHEKIRRFIERVKHGISGTK"
     gene            complement(15597..16364)
                     /gene="trpC"
                     /locus_tag="ACL8AS_000457"
     CDS             complement(15597..16364)
                     /gene="trpC"
                     /locus_tag="ACL8AS_000457"
                     /EC_number="4.1.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011227478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="HGS1228375.1"
                     /translation="MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDR
                     LQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREIS
                     SQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
                     ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTG
                     QDAERLAPYFNGILVGTALMQAENVAQRIKELQIDKG"
     gene            complement(16361..17365)
                     /gene="trpD"
                     /locus_tag="ACL8AS_000458"
     CDS             complement(16361..17365)
                     /gene="trpD"
                     /locus_tag="ACL8AS_000458"
                     /EC_number="2.4.2.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004048 - anthranilate
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="HGS1228376.1"
                     /translation="MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALK
                     MKGETPEERTAIARVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGG
                     IHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKY
                     IMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVA
                     GPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEGYAMEDIRGGNAQENAEILLS
                     VLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKALEKLRLLQEYQK
                     "
     gene            complement(17376..17942)
                     /locus_tag="ACL8AS_000459"
     CDS             complement(17376..17942)
                     /locus_tag="ACL8AS_000459"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004049 - anthranilate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046820 - 4-amino-4-deoxychorismate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HGS1228377.1"
                     /translation="MILLIDNYDSFTYNLAQYIGNFAEVQVLRNDDSKLYEEAEKADG
                     LVFSPGPGWPVDAGKMEDMIRDFAGKKPILGICLGHQAIAEVFGGKLGLAPKVMHGKQ
                     SNINFEAPSVLYQGIEDDRAVMRYHSILIEEMPEDFEVTARSTDDQAIMGIQHKNLPI
                     YGFQYHPESIGTPDGLSSIRNFIEKVVK"
     gene            complement(17939..19300)
                     /gene="trpE"
                     /locus_tag="ACL8AS_000460"
     CDS             complement(17939..19300)
                     /gene="trpE"
                     /locus_tag="ACL8AS_000460"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004049 - anthranilate synthase activity
                     [Evidence IEA];
                     GO_process: GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate synthase component I"
                     /protein_id="HGS1228378.1"
                     /translation="MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFSILAY
                     NPVFEIKFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAIGFVGYDMISL
                     YEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQEALEKSLNQV
                     LEELRIPAPNEFEDLDLSPLDFKPHIAPHKFEGMVETARDLIRNGDMFQCVLSQRFSA
                     EVTGNPFDFYRNLRVTNPSNYLYFYDFGDYQIIGASPESLVSVKNGIVTTNPIAGTRP
                     RGATDEEDKALATDLLSDEKETAEHRMLVDLGRNDIGRISETTSVQVTKYMEVELFRY
                     VMHLTSVVKGRLLAELTAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAI
                     GYLSATGDMDLAIAIRTIILKNQRAYVQAGAGIVYDSIAQNEYQETINKAKSMTRIGE
                     LRP"
     gene            complement(19672..19923)
                     /locus_tag="ACL8AS_000461"
     CDS             complement(19672..19923)
                     /locus_tag="ACL8AS_000461"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228379.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVSDRTDEVSSKYCFEVADRTDEVS
                     SKHCFEVSDRTDEVSNHTYGKATLTRFEEFFEEYKGVPR"
     gene            complement(20531..21532)
                     /locus_tag="ACL8AS_000462"
     CDS             complement(20531..21532)
                     /locus_tag="ACL8AS_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000789954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HGS1228380.1"
                     /translation="MKNINGKKVTIYDIARLSGFSPKTVSRVINGGVNVKEETYQAIQ
                     KVIEELSYIPNAYAKNLTKKEAINILISVKKIDSFPLIWFHTLLDKVLRTCKEFGVNA
                     IVEYFGEEDTISNSIISSTGSLVDGVIVFYESVDDIRIQYLKKNHMPFLVFGESQTSG
                     VVYVSNNNFQATYDMMKAVTEEKFKNMWLLMGGESHVNKDREKGVRSFLNDKNYFMDL
                     KVIYGLSTIDSVYSYAMQHLTTQNYPDIIFVSGDEKVQGLIRACYEKGILIPDDISII
                     GFDNIPISQYYTPALSTIAPNYVKLAKEMIEGVLAIIKGESVTSVEVSPKFVRRQSF"
     gene            complement(21640..22008)
                     /locus_tag="ACL8AS_000463"
     CDS             complement(21640..22008)
                     /locus_tag="ACL8AS_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228381.1"
                     /translation="MKDYKINFDLGKIEYFDNNCLIQVYKFISFYDICEMVFAFHLPP
                     DELITNVIFKEKINSMLKCYIDRLLYVFINPTHFTEKVNLQFYGSFFSYEFICREVGN
                     ILKNKGVKCNLNFFEGKEYL"
     gene            complement(22104..22814)
                     /locus_tag="ACL8AS_000464"
     CDS             complement(22104..22814)
                     /locus_tag="ACL8AS_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000127555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HGS1228382.1"
                     /translation="MTATSLGLSNIEIVVRIVLSVVIGSIIGLERGSKSQPAGIRTYS
                     IVCLAACLIMMTNEYVSYKFGTGDPTRLGAQVISGVGFLGAGTILITDKKKITGLTTA
                     AGIWASAGIGLAIGVGFYEGALLVAISVWGVISMFQPLKKYLQNRSKMIELYIVVKST
                     EVYNRVLVYCAENGIRMTDSRTAFGDVNSDRIEYFDVPDKKIASFITLELSGRFEHLR
                     LMEEIANIVGVIYVEEIS"
     gene            complement(22817..24508)
                     /locus_tag="ACL8AS_000465"
     CDS             complement(22817..24508)
                     /locus_tag="ACL8AS_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228383.1"
                     /translation="MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSL
                     DAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGILCVLFTEYFDIKGAKILKLGYMT
                     SLIYGGVVLATGYKFVYGPYGLITKFLQNVIPSLDPNWFIGYGAVLFIMTFSGTANHT
                     LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAA
                     PMIVGGKEFQTINPMIITFAGMGNSRDLAALLAIILGIATTILLTIMNKIEKGGNYIS
                     ISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPVAIQTGNLTL
                     SNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKSRFDFLFE
                     YGALLPWLLPSTLLAVSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVR
                     AILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLSVIALNFNSLLTDFDLSVFL
                     YHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRK"
     gene            complement(24520..25530)
                     /locus_tag="ACL8AS_000466"
     CDS             complement(24520..25530)
                     /locus_tag="ACL8AS_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228384.1"
                     /translation="MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTL
                     RALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPV
                     EIYHNSQTEFVCDFIGDINVLTDETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQ
                     DFILKGTIIDVEFSGVTIHYTIKVSENQILNVTSIDSQAAIRSVGESVELFITPSDVL
                     QF"
     gene            complement(25633..26700)
                     /locus_tag="ACL8AS_000467"
     CDS             complement(25633..26700)
                     /locus_tag="ACL8AS_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HGS1228385.1"
                     /translation="MKKMKVWSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQE
                     LVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIAGAQLADRVIAEKNNAVADMVFGIGA
                     VDSNKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDAKEMPKDWT
                     ELASKYKGQYSIYGLTGGTGRAIYASILVRYLDEKGDLGVSEKGWEVAKEYFANAYTL
                     QKGESTAVKVLDKENAIQYGMMWGSGALVGQKEQNVVFKVMTPEIGVPFVTEQTMVLS
                     TSKKQALAKEFIDWFGQSEIQVEYSKNFGSIPANKDALTELPEDTKKFVDQVKPQNID
                     WEAVGKHLDEWVEKAELEYVQ"
     gene            complement(26725..27384)
                     /locus_tag="ACL8AS_000468"
     CDS             complement(26725..27384)
                     /locus_tag="ACL8AS_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000793810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1868 domain-containing protein"
                     /protein_id="HGS1228386.1"
                     /translation="MKNLTKIKFKENGEFNHFPGNTVVANLYTKQDLMEVVDIIQSRY
                     RELPFIDKFTLTPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEI
                     FPLLDEEIHMRITEMGKQNILVEPADEASAKRLEEIRTYVSEKAGVCFPNHDRYQFHI
                     SIGYLRIPLTEEEEEEFTKVRAELTEILLEKIPTITVNRIDYTVFEDMRQFVPYHEKF
                     K"
     gene            complement(27564..27878)
                     /locus_tag="ACL8AS_000469"
                     /pseudo
     CDS             complement(27564..27878)
                     /locus_tag="ACL8AS_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996568.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
     gene            complement(28126..28422)
                     /locus_tag="ACL8AS_000470"
     CDS             complement(28126..28422)
                     /locus_tag="ACL8AS_000470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228387.1"
                     /translation="MVKINKICSIQGSSVENEDTVGSQNQYFGIIDGATDLYNSKEEI
                     GYSVSEVVHILSKSLSVNCKESKTLKQIFETALLEVKDEIGLNSYELTEYSKMK"
     gene            complement(28406..30565)
                     /gene="pfbA"
                     /locus_tag="ACL8AS_000471"
     CDS             complement(28406..30565)
                     /gene="pfbA"
                     /locus_tag="ACL8AS_000471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multi-ligand-binding adhesin PfbA"
                     /protein_id="HGS1228388.1"
                     /translation="MLKIVKKLEVLMKYFVPNKVFSIRKLKVGTCSVLLAISILGSQG
                     ILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTTNGLDNSLSVNS
                     ISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAV
                     GDGIHDDRQAIQDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILN
                     GINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEGTKAKNLPLI
                     NSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQ
                     IISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTL
                     STQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFDKKVKGESVHYRENGAALVN
                     AYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVIN
                     NNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYI
                     SFIKSNANEKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVI
                     DSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENHINKSKEIVDVK
                     QKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK"
     gene            complement(31695..32921)
                     /locus_tag="ACL8AS_000472"
     CDS             complement(31695..32921)
                     /locus_tag="ACL8AS_000472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="HGS1228389.1"
                     /translation="MPNYNIPFSPPDITEAEIAEVADTLRSGWITTGPKTKELERRLS
                     LYTQTPKTVCLNSATAALELILRVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVD
                     IQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDFFTASSKWQK
                     AFNRIVIVSDSAHALGSTYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPVID
                     DEEMYKEFQILSLHGQTKDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYP
                     SLLQRRKDIVDRYDSGFAGSRIHPLAHKTETVESSRHLYITRVEGANLEERNLIIQEL
                     AKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYII
                     ETFKTVSEKVLTLSKK"
     gene            complement(32964..33656)
                     /locus_tag="ACL8AS_000473"
     CDS             complement(32964..33656)
                     /locus_tag="ACL8AS_000473"
                     /EC_number="2.7.8.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000922225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HGS1228390.1"
                     /translation="MLKWEDLPVEMKSSEVESYYQLVSKRKGSLIFKRCLDWVLALIL
                     LVLTSPIFLILSIWIKLDSKGPVIYKQERVTQYNRRFKIWKFRTMVTDADKKGSLVTS
                     ANDSRITKVGNFIRRVRLDELPQLVNVLKGEMSFVGTRPEVPRYTEQYSPEMMATLLL
                     QAGITSPASINYKDEDTIISQMTEKGLSVDQAYVEHVLPEKMRYNLAYLREFSFFGDI
                     KIMFQTVFEVLK"
     gene            complement(33829..35580)
                     /locus_tag="ACL8AS_000474"
     CDS             complement(33829..35580)
                     /locus_tag="ACL8AS_000474"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228391.1"
                     /translation="MQNKQEQWAVLKRLMSYLKPYGLLTFLALSFLLATTVIKSVIPL
                     VASHFIDQYLSNLNQLAVTVLLVYYGLYILQTVVQYVGNLLFARVSYSIVRDIRRDAF
                     ANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVL
                     DFRLTALVLLFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFN
                     QEKRLQAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVLVAYFGYRGLSIG
                     ITAGTMYAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPLQENGQA
                     KVKEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYE
                     FQSGRVLLDDVDIRDFSQEELRKNIGLVLQEPFLYHGTIKSNIAMYQEISDEQVQAAA
                     AFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANID
                     SETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLTLGG
                     TYHKMYSLQAGAMADTL"
     gene            complement(35570..37315)
                     /locus_tag="ACL8AS_000475"
     CDS             complement(35570..37315)
                     /locus_tag="ACL8AS_000475"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228392.1"
                     /translation="MSIIQKLWWFFKLEKRRYLVGIVALILVSVLNLIPPMVMGRVID
                     AITSGQLTQQDLLLSLFYLLLAAFGMYYLRYVWRMYILGTSYCLGQIMRSRLFKHFTK
                     MSSAFYQTYRTGDLMAHATNDINALTRLAGGGVMSAVDASITALVTLLTMLFSISWQM
                     TLVAILPLPFMAYTTSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQAD
                     ELKSFQAVNELTFQKNLQTMKYDSLFDPMVLLFVGSSYVLTLLVGSLMVQEGQITVGN
                     LVTFISYLDMLVWPLMAIGFLFNTTQRGKVSYQRIENLLSQESPVQDPEFPLDGIENG
                     RLEYAIDSFAFENEETLTDIHFSLAKGQTLGLVGQTGSGKTSLIKLLLREYDVDKGTI
                     YLNGHDIRDYRLTDLRSLMGYVPQDQFLFATSILDNIRFGNPNLPLSAVVEATKLARV
                     YQDIVDMPQGFDTLIGEKGVSLSGGQKQRLAMSRAMILEPDILILDDSLSAVDAKTEY
                     AIIDNLKETRKDKTTIITAHRLSAVVHADLILVLQNGQIIERGRHEDLLALDGWYAQT
                     YQSQQLEMKGEEDAE"
     gene            complement(37521..37898)
                     /locus_tag="ACL8AS_000476"
     CDS             complement(37521..37898)
                     /locus_tag="ACL8AS_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HGS1228393.1"
                     /translation="MKRLIDGKPTLLIKNGNIDPEACRSVGLSASDVSLKLRSQGIFQ
                     MKQVKRAVQEQNGQLIVVQMGDENPKYPVVTDGVIQVDVLESIGRSEEWLLDNLSKQG
                     HDNVANIFIAEYDKGAVTVVTYE"
     gene            complement(37970..38426)
                     /locus_tag="ACL8AS_000477"
                     /pseudo
     CDS             complement(37970..38426)
                     /locus_tag="ACL8AS_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730499.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3290 family protein"
     gene            38560..39387
                     /locus_tag="ACL8AS_000478"
     CDS             38560..39387
                     /locus_tag="ACL8AS_000478"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006596696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HGS1228394.1"
                     /translation="MKLISWNIDSLNAALTSDSARAKLSQEVLQTLVAENADIIAIQE
                     TKLSAKGPTKKHVEILEELFPGYENTWRSSQEPARKGYAGTMFLYKKELTPTISFPEI
                     GAPSTMDLEGRIITLEFDAFFVTQVYTPNAGDGLKRLEERQVWDAKYAEYLAELDKEK
                     PVLATGDYNVAHNEIDLANPASNRRSPGFTDEERAGFTNLLATGFTDTFRHVHGDVPE
                     RYTWWAQRSKTSKINNTGWRIDYWLTSNRIADKVTKSDMIDSGARQDHTPIVLEIDL"
     gene            39399..39542
                     /locus_tag="ACL8AS_000479"
     CDS             39399..39542
                     /locus_tag="ACL8AS_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HGS1228395.1"
                     /translation="MDYNAVIPELLVSNIEQSRSFYCGLLGFRIEYQRPEENFLFLLK
                     SVN"
     gene            39653..39781
                     /locus_tag="ACL8AS_000480"
     CDS             39653..39781
                     /locus_tag="ACL8AS_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="HGS1228396.1"
                     /translation="MKANYPIYRPLTKRKFRVSDHYIYPHEFAVLDPNGYFLRFSE"
     regulatory      40164..40259
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            40659..41240
                     /locus_tag="ACL8AS_000481"
     CDS             40659..41240
                     /locus_tag="ACL8AS_000481"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016763 - pentosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0043101 - purine-containing compound
                     salvage [Evidence IEA];
                     GO_process: GO:0046110 - xanthine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HGS1228397.1"
                     /translation="MKLLEERILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAE
                     KFAATGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQ
                     VTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQD
                     GRDLLEKAGYPVLSLARLDRFENGQVVFKEADL"
     gene            41240..42502
                     /locus_tag="ACL8AS_000482"
     CDS             41240..42502
                     /locus_tag="ACL8AS_000482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001194492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleobase:cation symporter-2 family protein"
                     /protein_id="HGS1228398.1"
                     /translation="MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLT
                     YLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGAL
                     IASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
                     LAAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPIP
                     LYFGMPTFEISSIVMMCIIATVSMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAV
                     LLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSS
                     VLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTA
                     FQMFFSNGIVVASLLAIVLNAVLNHKKK"
     gene            complement(42589..43455)
                     /locus_tag="ACL8AS_000483"
     CDS             complement(42589..43455)
                     /locus_tag="ACL8AS_000483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II restriction endonuclease"
                     /protein_id="HGS1228399.1"
                     /translation="MKQTRNFDEWLSTMTDTVADWTYYTDFPKVYKNVSSIKVALNIM
                     NSLIGSKNIQEDFLDLYQNYPEILKVVPLLIAKRLRDTIIVKDPIKDFYFDFSKRNYS
                     IEEYTMFLEKSGIFDLLQNHLVSNLVDYVTGVEVGMDTNGRKNRTGDAMENIVQSYLE
                     AEGYILGENLFKEIEQNEIEEIFSVDLSAITNDGNTVKRFDFVIKNEQVLYLIEVNFY
                     SGSGSKLNETARSYKMIAEEIKAIPNVEFMWITDGQGWYKAKNNLRETFDILPFLYNI
                     NDLEHNILKNLK"
     gene            complement(43442..44212)
                     /locus_tag="ACL8AS_000484"
     CDS             complement(43442..44212)
                     /locus_tag="ACL8AS_000484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific DNA-methyltransferase"
                     /protein_id="HGS1228400.1"
                     /translation="MTKPYYNKNKMILVHSDTFKFLSKMKPESMDMIFADPPYFLSNG
                     GISNSGGQVVSVDKGDWDKISSFEEKHEFNRKWIRLAKEVLKPNGTVWISGSLHNIYS
                     VGMALEQEGFKILNNITWQKTNPAPNLSCRYFTHSTETILWARKNDKKARHYYNYDLM
                     KELNDGKQMKDVWTGSLTKKVEKWAGKHPTQKPEYLLERIILASTKEGDYILDPFVGS
                     GTTGVVAKRLGRRFIGIDAEKEYLKIARKRLEAENETN"
     gene            complement(44238..45092)
                     /locus_tag="ACL8AS_000485"
     CDS             complement(44238..45092)
                     /locus_tag="ACL8AS_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA adenine methylase"
                     /protein_id="HGS1228401.1"
                     /translation="MKIKEIKKVTLQPFTKWTGGKRQLLPVIRELMPKTYNRYFEPFV
                     GGGALFFDLAPKDAVINDFNAELINCYQQIKDNPQELIEILKVHQEYNSKEYYLDLRS
                     ADRDERIDMMSEVQRAARILYMLRVNFNGLYRVNSKNQFNVPYGRYKNPKIVDEELIS
                     AISVYINNNQLEIKVGDFEKAIVDVRTGDFVYFDPPYIPLSETSAFTSYTHEGFSFAD
                     QVRLRDAFKRLSDTGAYVMLSNSSSALVEELYKDFNIHYVEATRTNGAKSSSRGKISE
                     IIVTNYEK"
     gene            complement(45249..45653)
                     /locus_tag="ACL8AS_000486"
     CDS             complement(45249..45653)
                     /locus_tag="ACL8AS_000486"
                     /EC_number="3.1.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HGS1228402.1"
                     /translation="MKDFHFDAISAFENYEIEKMRDGHVVVTTKVVNSSLNYYGNAHG
                     GYLFTLCDQISGLVVISLGLDGVTLQSSINYLKAGKLDDVLTIKGECVHQGRTTCVMD
                     VDITNQEGRNVCKATFTMFVTGQRSEERQVRI"
     gene            complement(45723..47204)
                     /locus_tag="ACL8AS_000487"
     CDS             complement(45723..47204)
                     /locus_tag="ACL8AS_000487"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HGS1228403.1"
                     /translation="MTLVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNL
                     DKLIDLKDQLVEEAVRLETIEDSQTAREILGTELMDLVTPCPSQVNRDFWEAYAYSPE
                     QAIEDFYQLSRKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAVAKLV
                     QASNYPQCQLCLENEGYHGRVNHPARSNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFL
                     DGQHRPMAISRQSFERLLAIVEQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPME
                     LAPLQKTFRFAGFEQVKAGIIKWPMSVLRLTSDSKEDLINLADKIFQEWRQYSDSSVQ
                     ILAETDGTPHHTITPIARKRDGQFELDLVLRDNQTSAEHPDGIYHPHKDVQHIKKENI
                     GLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKAL
                     AIVKDSVGAIFVRVLEDAGVYKQTEQGQTAFMRFVEQVGILLD"
     gene            complement(47223..48401)
                     /locus_tag="ACL8AS_000488"
     CDS             complement(47223..48401)
                     /locus_tag="ACL8AS_000488"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000047000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004335 - galactokinase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA];
                     GO_process: GO:0046835 - carbohydrate phosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="HGS1228404.1"
                     /translation="MTQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGG
                     HVFPAAISLGTYGAVRKRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGV
                     LHFLQKAGHVIDKGFDFYVYGNIPNGSGLSSSASLELLTGVVAEHLFDLKLDRLDLVK
                     IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTN
                     KRRELADSKYNERRAECEKAVEELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRAR
                     HAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLERDYEVTGLELDTLVHTAWAQEG
                     VLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
                     "
     gene            48565..49572
                     /gene="galR"
                     /locus_tag="ACL8AS_000489"
     CDS             48565..49572
                     /gene="galR"
                     /locus_tag="ACL8AS_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding transcriptional regulator GalR"
                     /protein_id="HGS1228405.1"
                     /translation="MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEE
                     LGYTKHLKTGESHKPKQKIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYF
                     NDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTAI
                     KQVVDYFLSQGMDRIGILTGLEETTDQEEIIEDKRLENFRNYSQAKGIYHDELIFQGN
                     FTAQSGYDLMKEAIQSLGDQLPPAFFAASDSLAIGALRALQEARINLPDRVSLISFND
                     TSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLHGRKIPSLTMLGTRLTLRESTLNQ
                     E"
     gene            complement(49619..50658)
                     /locus_tag="ACL8AS_000490"
                     /pseudo
     CDS             complement(49619..50658)
                     /locus_tag="ACL8AS_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833740.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding dehydrogenase"
     gene            complement(50659..51012)
                     /gene="nmlR"
                     /locus_tag="ACL8AS_000491"
     CDS             complement(50659..51012)
                     /gene="nmlR"
                     /locus_tag="ACL8AS_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="stress response transcriptional regulator NmlR"
                     /protein_id="HGS1228406.1"
                     /translation="MNIKSASDLLGISADTIRYYERVGLVPPITRTATGIRDFQDQDI
                     EALEFIKCFRSAGVSVDSLVDYMSLYQKGDETREERLGILEEEKQKLEERLSQLQTAL
                     NRLNLKIKLYKEGKF"
     gene            complement(51256..52146)
                     /gene="czcD"
                     /locus_tag="ACL8AS_000492"
     CDS             complement(51256..52146)
                     /gene="czcD"
                     /locus_tag="ACL8AS_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation diffusion facilitator family transporter
                     CzcD"
                     /protein_id="HGS1228407.1"
                     /translation="MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDV
                     IAIGISAFLETISNREEDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHP
                     QPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
                     RFTDWYILDPLLSLVISFFILSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNV
                     ASLNQLNLWTMDALEKNAIVHVCLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLE
                     THQTHKRKVCDLERSYEHQH"
     gene            52279..52815
                     /gene="sczA"
                     /locus_tag="ACL8AS_000493"
     CDS             52279..52815
                     /gene="sczA"
                     /locus_tag="ACL8AS_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator SczA"
                     /protein_id="HGS1228408.1"
                     /translation="MTNIDRRISKTKKAIYQAFIQLLNAKGYEATTVQDIIDLADVGR
                     STFYCHYESKELLLDQLCRYLFHHLFEREQAISTEDYLAHLFLHFHKNQDHITSLLFS
                     KNDYFLRQLHKELEHHVYSVLADNLKEAHPNMPTSYLQHLVVSNFIETLTWWLKKGQD
                     FTDQEVVQFYLDLLIPKN"
     gene            complement(52981..53787)
                     /gene="pnuC"
                     /locus_tag="ACL8AS_000494"
     CDS             complement(52981..53787)
                     /gene="pnuC"
                     /locus_tag="ACL8AS_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015663 - nicotinamide mononucleotide
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0015890 - nicotinamide mononucleotide
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="HGS1228409.1"
                     /translation="MHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWD
                     DLFAHRSFAQWIYLLVLGSFPLWLELVYEHRIVDWIGMICSLTGIICVIFVSEGRASN
                     YLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQFKKEKQEFVARK
                     LDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITDATNGVGQILMTAVYREQWI
                     FWAATNVFSIYLWWGESLQIQGKYLIYLINSLVGWYQWSKAAKQNTDLLN"
     gene            complement(54132..55652)
                     /locus_tag="ACL8AS_000495"
     CDS             complement(54132..55652)
                     /locus_tag="ACL8AS_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate-binding
                     protein"
                     /protein_id="HGS1228410.1"
                     /translation="MTNLIATFQDRFGDWLTALSQHLQLSLLTLLLAILLAIPLAVYL
                     RYHEKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTLPALTALVIYAIFPILQNTIT
                     GLKGIDPSLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLATLIG
                     AGGLGSFILLGIDRNNASLILIGALSSAVLAIAFNFLLKVMEKAKLRTIFSGFALVAL
                     LLGLSYSPALLAQKEKENLIIAGKIGPEPEILANMYKLLIEENTSMTATVKPNFGTTS
                     FLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQDHLAYLKP
                     MSYQNTYAVAVPKKIAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGL
                     NLNVATMQPALRYQAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMK
                     EALLKKHPELERVLNTLAGKITESQMSQLNYQVGVEGKSAKQVAKEFLQEQGLLKK"
     gene            complement(55645..56373)
                     /locus_tag="ACL8AS_000496"
     CDS             complement(55645..56373)
                     /locus_tag="ACL8AS_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1228411.1"
                     /translation="MIEYKNVALRYTEKDVLRDVNLQIENGEFMVLVGPSGSGKTTMI
                     KMINRLLEPTDGNIYMDGKRIKDYDERELRLTTGYVLQAIALFPNLTVAENIALIPEM
                     KGWSKEEITKKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKILLMD
                     EPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVS
                     NPETILKAPATDFVADLFGGSVHD"
     gene            complement(56388..57152)
                     /locus_tag="ACL8AS_000497"
     CDS             complement(56388..57152)
                     /locus_tag="ACL8AS_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HGS1228412.1"
                     /translation="MSQQVKNAHNLYIHAIQDGRVAEAQAQSVGDTYIQHSTGVPDGK
                     EGFAAFFADFFERHPERQIKIVRTIEDGNLVFVHVHQYLNGGEAQWVTTDTFRADENG
                     CIVEHWDVIDYYRTPENDQLDQIFGDFEIKDLDKKAENKKLVRRFLTEIFQNGELEQW
                     SDYVADDLIQHNHEIGQGSAAYKNYVAEYSVTFDFVFQLLGQGNYVVSYGQTQIDGVA
                     YAQYDIFRLENGKIVEHWDNKEVMPKVEDLTNRGKF"
     gene            complement(57156..57599)
                     /locus_tag="ACL8AS_000498"
     CDS             complement(57156..57599)
                     /locus_tag="ACL8AS_000498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HGS1228413.1"
                     /translation="MKDSHLLAHHIRLLNGRIFQKLLSQDPEALYRGEQGKILAVLWN
                     SETGCATATDIALATGLANNTLTTMIKKLEEQKLVIVSPCGKDKRKKYLVLTELGKSQ
                     KEVGHRVSQKLDTIFYKGFSEEEIHQFEGFQERILANLKEKGNEV"
     gene            complement(58281..58577)
                     /locus_tag="ACL8AS_000499"
     CDS             complement(58281..58577)
                     /locus_tag="ACL8AS_000499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HGS1228414.1"
                     /translation="MVEPNLESLIKDLYNHARHDLSEDLVAALLETAKKLPTTNEQLQ
                     AVRLSGLVNRELLLNPKHPAPELLNLARFIKREEAKYRGTATSALMYEELFKML"
     gene            complement(58599..59663)
                     /gene="pepA"
                     /locus_tag="ACL8AS_000500"
     CDS             complement(58599..59663)
                     /gene="pepA"
                     /locus_tag="ACL8AS_000500"
                     /EC_number="3.4.11.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl aminopeptidase"
                     /protein_id="HGS1228415.1"
                     /translation="MTTLFSKIKEVTELAAVSGHEAPVRAYLREKLTPHVDEVVTDGL
                     GGIFGIKHSEAVDAPRVLVASHMDEVGFMVSEIKPDGTFRVVEIGGWNPMVVSSQRFK
                     LLTRDGHEIPVISGSVPPHLTRGKGGPTMPAIADIVFDGGFADKAEAESFGIRPGDTI
                     VPDSSAILTANEKNIISKAWDNRYGVLMVSELAEALSGQKLGNELYLGSNVQEEVGLR
                     GAHTSTTKFDPEVFLAVDCSPAGDVYGGQGKIGDGTLIRFYDPGHLLLPEMKDFLLTT
                     AEEAGIKYQYYCGKGGTDAGAAHLKNGGVPSTTIGVCARYIHSHQTLYAMDDFLEAQA
                     FLQALVKKLDRSTVDLIKHY"
     gene            60064..60765
                     /gene="galE"
                     /locus_tag="ACL8AS_000501"
     CDS             60064..60765
                     /gene="galE"
                     /locus_tag="ACL8AS_000501"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HGS1228416.1"
                     /translation="MTKTILVTGGTSYIGSHTVKALLNAGYKVHVLDNLSTGNRAAVD
                     SRASFKELDVYDASALKAYLEENQIDAVLHYTGEIVVSESIENPSKYFTANVAGMNQV
                     LKVLSEVGIQKIMFSSTASLYGNNCIDKPVTEDTLLDPVNPYAETKLMGERMIYWMAN
                     RYDWKYVIFRYFNVAGAEMDASNGLRVKNPTHIIPNINKTALGQNDSLKIFGDDYDTR
                     DGSCIRDYIYVLDLA"
     gene            60781..60891
                     /locus_tag="ACL8AS_000502"
     CDS             60781..60891
                     /locus_tag="ACL8AS_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase"
                     /protein_id="HGS1228417.1"
                     /translation="MNYLFQEDSSSQIFNLGTKKGYTIKEIFKTAEELLN"
     gene            61188..62147
                     /locus_tag="ACL8AS_000503"
     CDS             61188..62147
                     /locus_tag="ACL8AS_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228418.1"
                     /translation="MKLSHYLIGLLLLLVFLSISIGTSDFSWGKLFDFDQQTWLLFQE
                     SRLPRTISILLTASSMSMAGLLMQTITQNQFAAPSTVGTTEAAKLGMVLSLFVFPSAS
                     LTQKMLFAFISSIVFTLFFLAFMTIFTVKERWMLPLIGIIYSGIIGSVTEVIAYRFNL
                     VQSMTAWTQGSFSMIQTHQYEWLFLGLIILITVWKLSQTFTIMNLGKETSESLGISYS
                     LLEKLALFLVALTTSVTMITVGGLPFLGVIVPNLVRKRYGDNLSQTKLMVALVGANLV
                     LACDILSRVLIRPYELSVSLLLGIIGSLVFILLLWRGGRKDAD"
     gene            62137..63093
                     /locus_tag="ACL8AS_000504"
     CDS             62137..63093
                     /locus_tag="ACL8AS_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HGS1228419.1"
                     /translation="MQTKSKHTKLFWILIILAIGACLLYFWPITHLSAFAWKLRSQKI
                     IVYLLVAIATGISTISFQTLTENRFLTPSILGIESFYVLLQTLLLVFESKFLQLGKSP
                     ILEFLVLLLVQSLFFLALQGYLKTLMKQDLVFILLICLALRSLFRNISTFLQVLMDPN
                     EYDKLQNSLFASFQHLNTSILAIGSLIILALTIFFFRKAVVLDVLHLQRETAQILGLD
                     VEKEQKELLWGIVLLTSTATALVGPMAFFGFMLANLTYLIVKDYQHKLLFIVAILVGF
                     ISLTLGQALIERVFALEIRISMIIESVGGFLFFILLYRRSRQ"
     gene            63090..63842
                     /locus_tag="ACL8AS_000505"
     CDS             63090..63842
                     /locus_tag="ACL8AS_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228420.1"
                     /translation="MKLENIDKSIQKQDILQGISLEVSPQKLTAFIGPNGAGKSTLLS
                     IMSRLTKKDQGVLSIKGREIESWNSQELAQELTILKQKINYQAKLTVEELVSFGRFPY
                     SRGRLRSEDWEKIRETLNYLELTNLKDRYINSLSGGQLQRVFIAMVLAQDTDFILLDE
                     PLNNLDIKQSVSMMQILRRLVEELGKTIIIVLHDINMASQYADEIVAFKDGQVFSKGS
                     TDQIMQADLLSQLYEIPITLADINDKKICIYS"
     gene            63938..64903
                     /locus_tag="ACL8AS_000506"
     CDS             63938..64903
                     /locus_tag="ACL8AS_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1228421.1"
                     /translation="MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTI
                     KSSLDEVKLSKVPEKIVTFDLGAADTIRALGFEKNIVGMPTKTVPTYLKDLVGTVKNV
                     GSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIES
                     LASAFGETGTQKAKEELAKLDKSIQEVATKNESSDKKALAILLNEGKMAAFGAKSRFS
                     FLYQTLKFKPTDTTFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLE
                     NALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK"
     gene            complement(65128..65370)
                     /gene="yidD"
                     /locus_tag="ACL8AS_000507"
     CDS             complement(65128..65370)
                     /gene="yidD"
                     /locus_tag="ACL8AS_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HGS1228422.1"
                     /translation="MKRILIAPVRFYQRFISPVFPPSCRFELTCSNYMIQAIEKHGFK
                     GVLMGLARILRCHPWSKTGKDPVPDHFSLKRNQEGE"
     gene            complement(65370..66092)
                     /locus_tag="ACL8AS_000508"
     CDS             complement(65370..66092)
                     /locus_tag="ACL8AS_000508"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HGS1228423.1"
                     /translation="MRINKYIAHAGVASRRKAEELIKQGLVTVNGQVVRELATTIKSG
                     DKVEVEGQPIYNEEKVYYLLNKPRGVISSVTDDKGRKTVVDLLPNVKERIYPVGRLDW
                     DTSGVLILTNDGDFTDEMIHPRNEIDKVYVARVKGVANKDNLRPLTRGLEIDGKKTKP
                     AVYEILKVDPVKNRSVVQLTIHEGRNHQVKKMFEAVGLQVDKLSRTRFGHLDLTGLRP
                     GESRRLNKKEISQLHTMAVTKK"
     gene            complement(66079..66648)
                     /gene="scpB"
                     /locus_tag="ACL8AS_000509"
     CDS             complement(66079..66648)
                     /gene="scpB"
                     /locus_tag="ACL8AS_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_process: GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SMC-Scp complex subunit ScpB"
                     /protein_id="HGS1228424.1"
                     /translation="MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQ
                     KYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQ
                     PITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHL
                     EELPVIDELEIQAQESQLFGERIEEDENQ"
     gene            complement(66667..67395)
                     /locus_tag="ACL8AS_000510"
     CDS             complement(66667..67395)
                     /locus_tag="ACL8AS_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000351912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HGS1228425.1"
                     /translation="MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVST
                     LQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLL
                     GEHLEAKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHT
                     TILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEIITLFLATLELIKTQELI
                     LVQEESFGDIYLMEKKEESQVPQS"
     gene            complement(67395..68129)
                     /gene="xerD"
                     /locus_tag="ACL8AS_000511"
     CDS             complement(67395..68129)
                     /gene="xerD"
                     /locus_tag="ACL8AS_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase XerD"
                     /protein_id="HGS1228426.1"
                     /translation="MRDRISAFLEEKQGLSVNSKQSYKYDLEQFLDMVGERISETSLK
                     IYQAQLANLKISAQKRKISACNQFLYFLYQKGEVDSFYRLELAKQAEKKTEKPEILYL
                     DSFWQESDHPEGRLLALLILEMGLLPSEILAIKVADINLDFQVLRISKASQQRIVTIP
                     MALLSELEPLMGRTYLFERGGKPYSRQWAFRQLESFVKEKGFPSLSAQVLREQFILRQ
                     IENKVDLYEIAKKLGLKTVLTLEKYR"
     gene            complement(68126..68587)
                     /gene="cbpB"
                     /locus_tag="ACL8AS_000512"
     CDS             complement(68126..68587)
                     /gene="cbpB"
                     /locus_tag="ACL8AS_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0180001 - cyclic-di-AMP binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic-di-AMP-binding protein CbpB"
                     /protein_id="HGS1228427.1"
                     /translation="MIAKEFETFLLGQEETFLTPAKNLAVLIDTHNADHATLLLSQMT
                     YTRVPVVTDEKQFVGTIGLRDIMAYQMEHDLSQEIMADTDIVHMTKTDVAVVSPDFTI
                     TEVLHKLVDESFLPVVDAEGIFQGIITRKSILKAVNALLHDFSKEYEIRCQ"
     gene            complement(68584..69105)
                     /locus_tag="ACL8AS_000513"
     CDS             complement(68584..69105)
                     /locus_tag="ACL8AS_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HGS1228428.1"
                     /translation="MAKQTIIVMSDSHGDSLIVEEVRDRYVGKVDAVFHNGDSELRPD
                     FPLWEGIRVVKGNMDFYAGYPERLVTELGSTKIIQTHGHLFDINFNFQKLDYWAQEEE
                     AAICLYGHLHVPSAWMEGKILFLNPGSISQPRGTIRECLYARVEIDDSYFKVDFLTRD
                     HEVYPGLSKEFSR"
     gene            complement(69081..70052)
                     /locus_tag="ACL8AS_000514"
     CDS             complement(69081..70052)
                     /locus_tag="ACL8AS_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000182414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047429 - nucleoside triphosphate
                     diphosphatase activity [Evidence IEA];
                     GO_process: GO:0009143 - nucleoside triphosphate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-triphosphate diphosphatase"
                     /protein_id="HGS1228429.1"
                     /translation="MTNKIYEYKDDQDWYVGSYSIFGGVNSLSDYKTDFPLFEFSKIF
                     GDEEYGFPLSVTVLRYGSTYRLFSFVVDMLNQEMGRNLEVIQRHGALLLVENGQLLYV
                     ELPKEGVNVHDFFETSKVRETLLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEV
                     AETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRE
                     NNSKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGY
                     DPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL"
     gene            complement(70049..70843)
                     /gene="racE"
                     /locus_tag="ACL8AS_000515"
     CDS             complement(70049..70843)
                     /gene="racE"
                     /locus_tag="ACL8AS_000515"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008881 - glutamate racemase activity
                     [Evidence IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HGS1228430.1"
                     /translation="MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGP
                     RPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASA
                     AIKSSQGGKIGVIGTPMTVQSDIYRKKIHDLDPDLQVESLACPKFAPLVESGALSTSV
                     TKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLL
                     NYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL"
     gene            complement(71050..71298)
                     /locus_tag="ACL8AS_000516"
     CDS             complement(71050..71298)
                     /locus_tag="ACL8AS_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000364981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YneF family protein"
                     /protein_id="HGS1228431.1"
                     /translation="MDLLLAIVLIVLAFLGGALGGMYLVRKQIEKEFADNPRLNAEAV
                     RTLLSANGQKPSEAKVQQVYHQIIRQQKAALANNKKKK"
     gene            complement(71554..73179)
                     /gene="treC"
                     /locus_tag="ACL8AS_000517"
     CDS             complement(71554..73179)
                     /gene="treC"
                     /locus_tag="ACL8AS_000517"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008788 - alpha,alpha-phosphotrehalase
                     activity [Evidence IEA];
                     GO_process: GO:0005991 - trehalose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HGS1228432.1"
                     /translation="MTLDKGKVVYQIYPKSYKDTTENGIGDFRGIIEKIPYLAKLGVD
                     MVWLNPFYPSPQRDNGYDISDYMAVDPLFGDMADFEEMVCVGKEHKIDFMLDMVLNHC
                     STEHEWFQKALAGDKYYQDFFFIQDQPTDWQSKFGGSAWAPFGDTGKYYLHLFDETQA
                     DLNWRNSNVRKELFKVVNFWRDKGVKGFRFDVINLIGKDEVSVDCPENEGKPAYTDKP
                     IVHNYLRMMNQATFGSDDSFMTVGEMSSTTMENCVLYSSPDRQELSMTFNFHHLKVDY
                     KDGQKWTLAPFDFEELKSLYHSWGKEMSDKDGWSALFWNNHDQPRALNRFVDIQNFRK
                     EGATMLAASIHLSRGTPYIYMGEEIGMIDPDYDSMADYVDVESLNAYQMLLEEGKSQQ
                     EAFQIIQAKSRDNSRIPMQWDASENAGFSTGTPWLKAGKSYKYINVENEIQGPIFTFY
                     QDLIRLRKEMPIISEGSYKPAFEDSKQVYAFERQFEDQKLLVLNNFYAKEVEIDLPAV
                     YQNGQILISNYEDAEVSEKILLKPYQTLAIYVN"
     gene            complement(73357..75324)
                     /gene="treP"
                     /locus_tag="ACL8AS_000518"
     CDS             complement(73357..75324)
                     /gene="treP"
                     /locus_tag="ACL8AS_000518"
                     /EC_number="2.7.1.201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_function: GO:0015574 - trehalose transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0015771 - trehalose transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system trehalose-specific EIIBC component"
                     /protein_id="HGS1228433.1"
                     /translation="MGKFEQEAKDLLQAIGGKENVTAVTHCATRMCFVLRDDKKANVK
                     AIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVV
                     QGVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFL
                     WLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVASTPAADIAA
                     NWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPEVISMIFVPFLSLIPA
                     LILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAI
                     DTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQVSLPATISAYLGVTE
                     PALFGVNVKYIYPFVAGMTGSALAGMLSVTFNVTAASIGIGGLPGILSIQPQYMLPFA
                     GTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAEFVSHELVELTSVEII
                     SPLTGQVKELSQATDPVFASGVMGQGLVIEPSQGELTSPVNGTVTVLFPTKHAIGIVS
                     DEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDMDVIKAAGLVTETPVI
                     ITNQDAYTATIPGTYPTTIQAGASLMVATRI"
     gene            75509..76219
                     /gene="treR"
                     /locus_tag="ACL8AS_000519"
     CDS             75509..76219
                     /gene="treR"
                     /locus_tag="ACL8AS_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose operon repressor"
                     /protein_id="HGS1228434.1"
                     /translation="MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVR
                     KALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDK
                     IIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
                     SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTE
                     SRHKLEKFRFVDFAKRKK"
BASE COUNT        23100 a        16737 c        13393 g        23076 t
ORIGIN      
        1 tattaaagtt atataatagt attaatcaaa gaaattgatt ttttgatatt aaaataaaaa
       61 aggagggtag gcagtgttgt gatcaattat tgctggaggt cttattggtc tcttggcagg
      121 taaaatcact aaaaaagtag ttctatggga atcatcgcaa atgtattcgc tggtttagtc
      181 ggggcatatg caggacaatc tcttttaggt agttggggtc catcaatcgc tggaatggct
      241 ttgctcccat ctattgtagg tgcagcgatt gtgattactg tagtgtcatt ctttacaggt
      301 agaaagtaaa cttttcgcca gtaaagttag caaactattt ttaaatcaat gacgggaaaa
      361 atagtttaaa tgttaaatcg aaaggattgt atatgtcaaa agcaaagaaa atatgtttca
      421 ttattttctg tattttaatc ttgacaattt tccttcctgt tttgatagat tatcatcaag
      481 ttagtgatct aggtattcat ctacttagct ggagacagaa ctccgtagtt gaattctatc
      541 ttgctagata tgtcttttgg gggacagtgg ttctatcaac tttagtttta ttatccattt
      601 tagttgtgat gttttatcct aaacgttact tggaaatcca acttgaaact aaaaacgata
      661 cattaaaatt aaagaattcg gcaatcgaag gttttgttag aagtttggtg agtgatcata
      721 gattgatcaa gaacccaact gttcatgtaa atttacgaaa aaataaatgt ttcgttcatg
      781 tagaaggtaa aattcttcct tcagacaaca tcgctgacag atgccaaata attcaaaatg
      841 aaataactaa tggattgaag cagttttttg gtattgagcg tcaagtaaaa cttgaagttg
      901 cagtaaaaaa ttaccaacca aaacctcaaa acaaaaagac tgttagtcgt gtgaagtaag
      961 gaagtaaaaa atggaatggc ttaaacaata tcgatatcca attatcgctg gtctcatagg
     1021 cgtatttctg gcttgtttga ttgtctcctt tggcttcttc aaaacaatat ttgtattgat
     1081 tttaggagca ctgggagttg cagctggatt atatatcgaa aaaaactata tagataaata
     1141 aaaaaataaa aattactaat ttaattaaag gagtttcata tgtcaaacga aaaaaacaca
     1201 aacactaacg tagaaaagaa agatgctact gttgtagctc acgaaatcaa aggggaactt
     1261 acttacgaag ataaagttat ccaaaaaatc attggtcttt cactagaaaa cgtttcaggt
     1321 cttttgggaa tcgatggtgg tttcttctca aatcttaaag aaaaaatcgt taacagcgat
     1381 gacgtaacaa gtggtgttaa cgtagaagtt ggtaaaacac aagttgcagt tgacttaaac
     1441 gttattgttg agtaccaaaa aaatgttcca gctttatatt cagaaatcag agaaatcgta
     1501 tcttcagaag ttgctaaaat gactgacttg gaaattgttg aaatcaacgt aaacgttgtc
     1561 gacatcaaaa ctaaagaaca gcatgaagca gactcagtaa gccttcaaga tcgcgtatct
     1621 gacgttgctg aatcaacagg agaattcact tcagaacaat tcgaaaaagc taaatctggt
     1681 cttggatctg gtttctcaac tgttcaagaa aaagttagcg aaggtgtaga agctgttaaa
     1741 ggtgcagcaa atggtgtagt atctcacgaa aacactcgtg taaactaaga taaaataaat
     1801 ataacaggag aaattatcat gtcagtagaa gaaaaattaa atcaagctaa aggttctatt
     1861 aaagaaggtg ttgggaaagc catcggtgat gaaaaaatgg aaaaagaagg agcagctgaa
     1921 aaagttgttt ctaaagtaaa agaagtcgcc gaagatgcca aagacgctgt agaaggtgct
     1981 gtagaaggtg ttaaaaacat gttgagtggc gacgataaat aaggttaaaa gttactttat
     2041 ctttttagta acattagtca aaagagtctg agtcaagatg attctcagaa aacaaaaagc
     2101 tagggattcc caattgcgga actctagctt tttaattttg cctctttctc ttattatatt
     2161 tcagcaggtt gttggccatg agtacgaatc ccatgtcaat tctcacttga cgcttccctc
     2221 tcagatgaca tctcttataa cccaaacaaa cctttatctg cccaaagaca gatttcatat
     2281 caatcttacg tttagcgaaa atttgtctac ccttggaaga taaaagtgcc tgatattctt
     2341 tagtttttaa acactggtaa cgttcattca tatacagtcc cttttgaggg gctgattcag
     2401 gttcataatc gcagtcaaca ttgatttcaa ggctgtttgc tttctatcta ccctttttca
     2461 tgatatattt tcgtacaggt tcttcaatag tttctatagt aaaatgaacc aaaaatagta
     2521 cacgttgcgg tataatgttc ttgtggcata ttcattagat tttcgtaaac agttctctcc
     2581 tatttgtgag cgaacaggta tagtcaattg attgtcagtt tgaagaccaa gagtcgtaag
     2641 gcaaaggata tggcagaatc catccaaggg tggctggcac aatttctagt gaacctcttt
     2701 aaatctatta cgtttgactg tggaaaagag ttttcaaaat ggaaagatat ttccaatcat
     2761 cacgatagtg agagcttttt tgcgaatcta ggatgttcaa gacagcggtg tctcaacgaa
     2821 cattcaaata gacttttaag gtgtcatgac ttgccaaagc agacagattt caacgaagtc
     2881 agtcaagaat tttaggctgg acaaaaactc aatttcagga gaaaatgaaa taaatattcc
     2941 cacaataaaa cgcatagtat caaagttttt ccaacacctg atattatgca ttttttaatt
     3001 ttaaagactt tttcccagcc tcaagaaatc acatcccacc taaatccttt ggataccaaa
     3061 tacctcatca gatattttct gagttggtaa gactgtctag cttaatttga caaatggagg
     3121 gcgttaaatc cagtttttac aggaagtcta tttaaatatt ttcacactga ccttacaaaa
     3181 tatgaaataa attatataaa gtcattccca tgacaaagaa taacatccct ttaaaacagt
     3241 atcttaccca attttcaggt aagacttttg atacaaccgt ccccaatacc cctccgcata
     3301 tagaagcaag aaaaataact ggaacaggtg ctaaatgata ctgatttaaa cctgtaacca
     3361 caacaattgt agccaaatga gacagctggg aaaagaaaat aattgcaaga gaatacatcg
     3421 ttgcttcttt tatcgaaata gaaaaaaaca ccatcaataa agatacattg agcggaccac
     3481 caccaatccc taaaaaacta gaaattaagc ccaatagaag accacaaatc atatagaatc
     3541 ctatcttatc aaattgataa gtttttttaa aatctgttaa aacaaatgat acaagtagca
     3601 tcacaaatag taaaatcatt tgaacaatgg atactagccg tactgataat tgagataaca
     3661 aaacttgaaa aataagatga cctagaaatc ctcctaaaac agaagaaaag gataccgtaa
     3721 aaatcaatct ccattttatc tctttacttt gtgaaaatct tttgattgtt gaaataatcg
     3781 ccattataaa aacagagaaa ctagaataaa aagcaatatc actgaccgaa tggtacccaa
     3841 aactatccat aagtggctta attataattc caccacccat gcctgatata gaacccaatc
     3901 cactagctat tataatgatt agaaaataaa taatctcaac cactttttaa gtccatccta
     3961 ttctttcaaa catctaaaac ctagatggct actagtggaa gtagaaatac atccatttct
     4021 agcagctact cggtatcgat tacaataaga acaatgacat aaaaaggaac ctcctctgat
     4081 agcatactcc tcatcttgta tcccatattt tggcaactca tagtcatctt cattaaaact
     4141 agctaataag gtatatctcg gattgcgaca ccattcccaa acattcccaa tcatttgata
     4201 tagaccaaaa tcattaggta aaaattcata gacaggagcc gttcctataa atccatctga
     4261 ggcagtattt tcataaggaa atcttccttg ccaagtattg gcatgataat atccaccttc
     4321 taaaagagta tctccccaag gatattcaga ttgtcttcct cctctagcag catattccca
     4381 ctgtgcttca gtcggtaaag acattccgct ccaattacag aaagccaatg catcttctaa
     4441 agcaacatga actactggat ggtcttctaa acccactaga ttactattct caccgtaggg
     4501 atgtttccag caagcgttcg gaacttgtaa ccaccacgga gccccagcag gatgaggata
     4561 tccctccctt tctgcctctg gcattaatat ggtttcctgg aatcacgttc ccaatagtta
     4621 ccatcagatt tttaccatca aatgctagat tatcaattcc ttgtaagatt tgatctaatt
     4681 tcacatctcc tacatttgcc aaagggaaac tctttgtaac tgtacttcca atcgaaatga
     4741 caaacgaagc aagtgatacc aaaccagcag aaactgtatc aaccttgtaa atcttagcga
     4801 tattcactcc caagcaatag atgaacaaca aggaaacaat tggtatactt cccttgaata
     4861 ccaaattatt gatgtcaaca agccactgaa aggttttcgt aatactttct aggtgaaatt
     4921 gttgtggtaa atccactaga aaagcattta ataacaaagc aatggaacct gtcataataa
     4981 caggcatagt ccccacaaat gaatcacgta aagcaactaa aaacttctga ttcccaactt
     5041 tcattgcaat tggagaaagt ttttcttgca ttttatccaa cattgtattc ataccaaact
     5101 cctaattttt ttcaaatcgt tcgtatactt ctaccacttc tttcgccaag tcaacaaaag
     5161 tcaaactcgt cattaaatga tcttgcgcgt gtaccatcaa gaggctaatt gatgtttttt
     5221 ccccctgtgc ctctcttgtc aacatttctg tttgagcctt atgcgcctgt aataaggcag
     5281 cattcgcatc agctaatctt cgattggctt tagagaaatc cccttttttt gctgcctgaa
     5341 tagcctccat agcattactt ttggcttccc caccatacat aattagcccc attacagatt
     5401 ctaaattact ttcatccata acattctcct caatcttagt ctaataaact ttcagctaaa
     5461 tctaaaactt tagaaccatt catcattccg taatctgtca tcggaataac cgccacagga
     5521 atctgtctat cttttagttt ttcttgaaag tcccctagta aatagcgaac ttgaggacct
     5581 aaaagcaaca catttacttc ttttgttgct acaatttctt ctgcttcagg agctggaact
     5641 gcaaaaattt ctgcatccaa ccccttatct tctgctgcct tttgcatctt tgtcactagc
     5701 agacttgtac tcatacctgc tgcacatgct aacataattg ttactttagc catagcttac
     5761 tcctttatca cctatttact gacctagcca agcgagatac tgtatgtctc actcctctaa
     5821 ttgccttgct caatgcataa atattatcga ctgttgccag tcccccatat cctgcgtcac
     5881 ctatatgttg aatatcaact ccacaaattt tatttctaag tgcaatttcc ttgatagtat
     5941 ctgtatcaga tgtttcttgg ctagtaccaa tagcactcaa tacaagacca cccttactat
     6001 gaacgagatc aacgacttca cgcaactctt ggtcatgaaa ggctggaacg gttccaactg
     6061 ctggaacaag tatcacatcc gcacctgctt ccaacaattg ctctgcgaca gaaagctctg
     6121 ccacaggctc attcactcct gccccgtgca ttttaccagc tataatcaaa cctgagaaat
     6181 tctctttagc agattgaact gctttgataa tctcttgatt gctaactcct gttccaggat
     6241 ttccagtcaa acagacaaag tcaaaaccta actcctctat tcgcttcaat gtttcaacac
     6301 tagcaacacg acctgcaaca atttcctgtg tttcctctag catctttgca gatgggtcaa
     6361 tcggttccaa atttacacca attggacaag caacaagctg gtgtaagcga tgaataacat
     6421 catcacctga actatccaaa gcataaattt taggctcaaa aacatcaaca caattcaata
     6481 aaatcatatc agctccaaaa gctctagcaa tttcagaatt agttatatcc ccaacaaatg
     6541 tctcacgagt aactacattt tcagatagaa caactctacc ttcacttgct aaaatacttt
     6601 gttttaattc ttcagcattc atctgtaata tctcagatgg atttgcacta attaaacgtt
     6661 tcattctcaa tcctccaata acttaaaccg tttttcaata gctattacaa atggtaaata
     6721 aagtaagaca tccaaaacaa tcaatacaat ttgtaataat gaaccagaaa tacttcctgt
     6781 agcaagtaaa ccacttataa caggtggcat agtccaacct ggatctgtat aagttagcgg
     6841 aaccaaacct gatgccattg ctccccacgc tactagtaag ttaaacattg gagctaagat
     6901 aaatggaact agtaacaaaa tgttcaaaac aataggaacg ccaaacattg ctggttcatt
     6961 tatattaaat aatccaggta taacagttat aggtgccaaa gtttttagtt gtttactagc
     7021 tttcttctta tgtgctaaat atcctaacgc aagaactaaa cctatggttg caccaccgcc
     7081 acctatgaat acaaaattat ccataaatac gctagtaaaa atatttggaa gagtttctcc
     7141 agtttgataa gctactttat ttgcatctag attagctaac cataacggtt tcataactgc
     7201 attaacaaca tttcctccgt gtaatcctac aaaccaaaaa ctactattaa ggaaaattaa
     7261 gataagaaga ccaataacat tatttcctaa aagtccaagt ggacctccca aagctacttg
     7321 agcaatttca tgaagattag gtaaacttaa tttatctaaa gttgcataaa caatcaacca
     7381 accaacaata gtcactgcac caggaataat ggcactaaag cttttagata ctgctggtgg
     7441 aacaccatcc ggcattttta tctgtatatt atgatttata aaccattggt agatatagcc
     7501 attaatcaat cctaaaatca tagcaacaaa taaacctttt gatgccatga aagcggtagg
     7561 cattcctgct ccagcctctc ctctaatgaa aggcgtaact gtaataaaag atgataatga
     7621 cacaatacca gcaggaatac catcaacttt gtattgtcta gccataaagt aagcgatacc
     7681 aaaactagct acaagaccaa gtaatccaaa actactatca acacccttcc ataaatagtc
     7741 agcaacacca atatcaccca gatatttttc ccatcctgga ataggaaaac ttgcaataac
     7801 cattagtaat gaacctatca acaataaagg tatagttaga gtaataccgt ctcgaataga
     7861 aaccaacgct ttattattac ccaatctagc cgctactgga agtaactttt cttgtaataa
     7921 tttttccata accttttcct cttaaatata ttttattatc aaaagttatc aattatcttt
     7981 attttttgac gtcaagttgt tatttgatta tcttttgtta tttatatttt acaactataa
     8041 gaaagccttg tcaaggattt gtgtaaacat ttgattattt tttattatca atatataata
     8101 aaaagagact agtaagtaat gaaaagctta aaaagattaa catctacatt tatccatagc
     8161 aaaaaatcat aggattttaa gaatctgaca actaggaaga aaactaatat gaccttatct
     8221 aagaaacaat tacaactaag agctaaaata ctggaaacag tttacacatt aggtcccatt
     8281 tcacgaattg aaatcgctac taaaacagga ataacacctg caacaactag cagtatcaca
     8341 aatgatctga ttaaagaaaa tattctctta gaacttggtg aagacgaaca cgatacaagc
     8401 gtagggagaa aaaaaatcct gctagacatt caagctaaac gattttacta cattggttgt
     8461 gaactatctg aaaaacattt cacttttgct ttaggagata atctaggaaa tatcttaaag
     8521 gaagagaaag aaattgttac taaacagtta atccaagaaa agggaaatca actcattaac
     8581 cagacactaa agcaattctt aaataactgc tctgattatg aaatagaagc aattggaatc
     8641 gcgctacctg gtcgctattt agataattat aaaataacaa caaacaatcc tttatggcaa
     8701 catatcgact tagaaatgat tcaatcccac tttgataagc ctttgttttt ctctaacaat
     8761 gttaactgta tggctatagg taaacgccta tttagtcgcc aacagaatga ccctaatttt
     8821 gcttattttc attttgctag aggtatgcac tgttcttata tctacgacgg aaacatttat
     8881 gggaaaggaa atctaatgat tggagaaata gggcatacag ttgtttcatc tgagggagaa
     8941 gaatgtagct gcgggcgcaa gggatgctta caaacttttg ctggagaatc ttggttaatc
     9001 aaaaaatcaa aaattctata tcatcaatct ccctattctc tacttcctag tttagtcaaa
     9061 aatgccgatg atattgatat ccaagttatt ttaaccgctt atcaattagg tgacactgga
     9121 ataatcacac ttatccatca agccttactc tatcttagtc aaaccatttt aaatatcagt
     9181 atgatgattg actctcaaaa aatctaccta catagtcctt tactaacaaa tcaacacatc
     9241 atccaaaaac tatatagtga aatgaactac aaacccaaac tgctctataa tcgcctacct
     9301 gaagtcatta ttgaacctta caatgatttt acagccgcac actcagctat tgcactttgt
     9361 ttgtatcata caattctaca ttcttaattt tctattacat ttaataaata ggctaaaaag
     9421 agggagtata tcataaaaag cgaataaacc tgttttctga aaatcagaat tctgttttgt
     9481 tcgctttctt tatatttgga attatactcc tatctcccct ttttcataat gtataataaa
     9541 atgaaataat aacaggacga atcgatcggg acagtcaaat cgatttctaa caatgtttta
     9601 gaagtagagg tgtactattc tagtttcaat ctactatatt ttcgtacagg tgcttcaacc
     9661 atttgaacga tttcaaatcc ttctttttgg taaagattct gaactctttg atttgcctcg
     9721 aagacattta gagaaatact atctatatct tcattttcaa aggccaaact aacaaatttc
     9781 cttaaagcct ggctacctaa gtcttgctcc tgtttctggg ggttgataaa aaatctcccg
     9841 atatgaagat tgctgtcttc tagcctgatt ttctggataa atcccacaaa ctcttgttca
     9901 tcaaagattg aaaagactcc ttccaaggct tgaagggtca gtagaaaagg aatccttggt
     9961 cccatccatt gttcttgaaa ggatttgcct agggagttgg accactggca tacaaattga
    10021 gcgttttctg tgctcacctt ttcttcaaaa cgaattgtca tcttttcctc accaccttat
    10081 ctatgtttct ccattatact atttctccca ttttttacga atagataagt atgattgatt
    10141 tttatttttt tctcgtcggg agcattctag cttcctttct tggtttggtc attgaccgtt
    10201 ttccagagca atccattatc agttcagcca gtcactgcga ttcctgtcag actcgcttgc
    10261 gtcccttaga tttgattccg attctctcac aggtcttcaa tcgcttttgc tgtcgctact
    10321 gcaaggtccg ctatcctgtc tggtatgccc tctttgaact aggcttagga ctcctctttc
    10381 tgctttactc ttgggaatta ctttccttga gtaaagtcat cctaatcact gctggtttga
    10441 ccttgggcat ctacgacttt cgccatcagg aatatccctt actggtctgg atgactttcc
    10501 acctaatcct aatagcttcc tctggctgga atctggtcat ggtctccttc cttgctcttg
    10561 gaattttggc tcattttatc gatatccgca tgggcgcagg agatttcctc tttttagctt
    10621 cttgtgctct cgtctttagc gtaacggagt tactgatctt gattcagttt gcttctgcga
    10681 cgggtatcct ggcctttatc ctgcaaaaga aaaaggaaag acttcctttc gtgcctttcc
    10741 tcttacttgc tacttgtttg attatttttg gtaagctact gcttgtttga taaagtccaa
    10801 tttctgccat atgtccttca tgaaattatt tcacagttaa attataaatt atttcttttg
    10861 tacaaaggga tgatgttatc aaatcgatct gttcttctat cttcttgata ctgatcaaaa
    10921 aatttcattt cgactgaaaa tatttcgctt ataaactgta aacgaatact ttgtttagac
    10981 attatagtcg ctagactgac tagatgatta ctcaaaacga cgtccagaat actctttact
    11041 ttgcttggtt ttttaacaaa aatttgatca tccaaaggtt caatcatttt gtaacctttt
    11101 tgcgcaattt gacgataaaa gtaagaatgt tgctttggag tcaataatcc taacttaaaa
    11161 gctcgatact ctaaagcctg tatcgaaaca ttcaaatccg acttcaataa aatataacta
    11221 tcaggattgc tgacacgctt gccaaccctc tcttcaaatt tgactaaaaa ctcttctttt
    11281 ggcaataaaa aacatgatgc aaaataattt gcttcttgct ccaaacgatc gccatcttca
    11341 ttcatatctt tatatttatg taaaagaata tgtcctagct catgagctaa gtcaaaattt
    11401 cgacgtacag atgatttatt cgttcccaac acaatataag gtcttcccaa ttttgaccat
    11461 gcgctataag catcagcttg gccattaatt aatcgttcca cgatatagat gcctgaacgt
    11521 tctaatttat aaagcaaatc atgattatct tttgaaatac ctaatttttc cctggcataa
    11581 agagccaatt cctcaatgga ttctccctta tgataagatt cactcactac attacttagg
    11641 tcatgaatta taatattagg tataattata aaactttcaa aataatcaat caaactatct
    11701 accttatgta aatacatagt ttgaatatct attgttttcc gtgttgctag gtctgcattt
    11761 ctaaaggcaa ttacagaaga atcaaatcga atgctctctt cttcctgttc aaaataagtt
    11821 aaatcaacat gaaattggtt ggccaaatgc attttggttg ataatttagg tttcgtttcg
    11881 ttggactcaa actgccaaat ggcttgttcc gttaaattaa ttctctgagc taattctgct
    11941 ctacttaaac catttaacag ccgtaattct ttcaataccc gaccattaaa catttacata
    12001 ctccttacta cttttgacct tcttgttttt ctattcttgg aataatttca aaatcttctg
    12061 tttccgataa ttctgaaaaa ttaggaatat cttgatattt agcttcttcg aaatggtacg
    12121 aacttgattg aatatactca gacaaatctt gaatcaagtg taactgacca gttcgtgcat
    12181 caggcataac aacatctaca gatataatat tgttttctga gtccgcctca taagttaaaa
    12241 tcataaattt ttcgatattc gaatttttag tagcttgttc aatttcttga atcatttcat
    12301 cagaaactaa ctccatctga attggaaagg aatgactatc ttcatcattt ttgtaggaag
    12361 aatgttgatt aagataaagt gtattcatct gagcgtattc aaataagtag ccactcttat
    12421 ttttttgtac caaaggaaat tggttcgtaa gtcgcttctt accctttata attaacaata
    12481 ctttcccata tttttctgta tttgtttcaa attctaaata tccccaagtc tgtcctgcta
    12541 attgtaattt atactcaaac aaatctgctg atgcaaatgc agtatcaata tgattaggtc
    12601 gcgtccatgc ataaccattc gacactatca ttgtctctct tttttctaga cgttcatcta
    12661 cataatcttt ttgccctttc atcaaagtat ctacaatttt ttgtgcctca agcgaatcaa
    12721 agagatcctg attcaacata attcttcctc ctccaaatac tttttaatga attatatcat
    12781 tttcttaaag aaattactac aataattagc tttttcttaa agttctgtgt cagagtaatt
    12841 tagaaaatta tatcttctat agtaaaatca attaaaaact gaacaaattt attgggaaat
    12901 tcaaatcact ttctgaaaat attttaggaa ccgtagtgta atattccaga ttcaattcac
    12961 tataaaacta gcctttctcc tgcaaaagaa aaaggaaaga cttcctttcg tgcctttcct
    13021 cttacttgct acttgtttaa ttatttttgg taagctactg cttgtttgat aaagtcctga
    13081 atcggctctc cttggtggag agcttttact attttcgaac cgacgataac accatctgac
    13141 accgcattga agcgttccag atcggcttga ctagatacac caaaacctgt caagactggg
    13201 atgtcggcca cttgatgaag ttgcgccaag tgcttgtcca aatctgcacg gtaattgcct
    13261 gatttccctg ttaccccatt gatggcaacg gcatagacga atccctccgc cccttcaatc
    13321 aactctttct ggcgctcaat tcctgtggtc aagcttacta aaggaatcaa ggcgatatct
    13381 gtatctgcca aaaatggttc tacaaagttg gcatgttcat gaggcaggtc tgggataatc
    13441 aagcccttca cagctgtatc agccagatct ttgacaaagt tctccacacc gtactgaaag
    13501 agggggttga agtaggtcat gatgaccagt ggaatctctg tttcaatggt tttcaaggtt
    13561 tcaactaaag cctgggtaga ggtcccgtgg gctaaactgc gcaagccagc ttcttcgata
    13621 acaggtccat ctgcaacagg gtctgaaaag ggaataccca cttcaattgc agagacaccc
    13681 aaatcttcta aaaagtgaat tgtttcagca agaccatcca aacctttttc gtggtcacca
    13741 gccatgatat agggaacaaa aattcctttt ccagctgctt taatagcatt taattttttt
    13801 gttagtgtct taggcatgag cttctccctt ctttgctgca tctgcttcca agcggtcttt
    13861 tacttgaacc acatccttgt ccccacgacc tgataggcat acaatcatag acttttctgg
    13921 tccaagttct ttggccaatt tcaccgcaaa ggcgatagca tggctagatt ccaaagctgg
    13981 gataatccct tccacacgag acaagagttg gaatccttcc aaggcttctt cgtctgtcac
    14041 agggacatag ctggcacgtt taatatcgtg gtagtgagaa tgctctggac cgataccagg
    14101 atagtccaaa cctgctgaga tagagaaggc ttcaagaatt tgaccatggg catcttggag
    14161 cacatccatg agggaaccgt gaaggacacc tggacgaccc ttggtcaagg tagctgcgtg
    14221 gtgctccgta tccacaccaa atccagccgc ttcagctcca tacatggcta ctgactcatc
    14281 ttctacaaag ggatggaaga gaccgatggc attcgaccca ccaccaacac aggctactag
    14341 ggcatctggc agattttgtc ctgtcaagtc acggtactgt tgtttagcct ctcgaccaat
    14401 gacactttgg aagtcacgaa caatttctgg aaatggatga ggccccaagg cagaaccaag
    14461 gatatagtgg gtatcatcta tattagccac ccatgaacga agggctgcat tgaccgcatc
    14521 cttgagcacg cgcgaaccat ctgtcacggc ctcgacctta gctcccaaaa gctccatacg
    14581 gaagacattg agggcttggc gtttgacatc ttcctcaccc atgtagatgg tacattccat
    14641 gttaaagagg gccgcagcag ttgcagttgc cacaccgtgc tgaccagcac ccgtttctgc
    14701 gataattttc tttttaccca tgcgtttggc aagccaaact tgtcctaagg cattgttaat
    14761 cttgtgggct cctgtatggt taaggtcttc ccgtttgaga taaatcttgg ctccgccgat
    14821 atgctgggtc aagttttttg cgtaataaag aggagtttca cgtcctacgt actggcgcaa
    14881 aagctggttt aattcctctt ggaaacttgg gtctgcctga ctttcacggt aggccttctc
    14941 caactccaaa actgctgtca tcaatgtttc tgggacaaaa cgtccgccga attttccgta
    15001 aaatccatct ttatttggtt cctgatatgc catgctttac cctctctata aatcttctaa
    15061 tcttttcatg atctttttgt ccatctgtct ccactccgct cgatacatct actgcatagg
    15121 gagtaaaatg ttgaattgct tttactacat tatcttcatt aaggccacct gcgataaaga
    15181 agggctgtgc tagtccagtc gtatccagtt gaccccaatc aaagggctgg ccacttcctg
    15241 ccacaggggc atcaaagagt agataatctg cctgagaatt ggggacatgc ccatttccat
    15301 ctacctgcac agcctgaata ctggcacaag gcaaattctc aaataaatca tctgccacct
    15361 gaccgtgaac ttgaaccaag tccaagccaa ctttgtcaat cgcttccagc agttctaccc
    15421 gacttggtga aacaaatact ccaacctttt tcacatctgc aggaataagc tttgccaaca
    15481 cagctgcctc ttctaaagtc acctgtcttt tactaggtgc aaagacaaaa ccgatatagt
    15541 cggctcctgc tgaaacggct gtttccaccg cttctttggt cgatagtcca caaattttaa
    15601 cctttgtcaa tctgcaactc cttgattctc tgggccacat tttctgcctg cataagagct
    15661 gtccctacca aaattccgtt aaagtatggg gctagtcgtt ccgcatcctg ccctgtgaaa
    15721 atggcagatt cagaaatgta atagcgacct tcctcaaagt aaggggctaa atctacactg
    15781 gtctgcaagt cgacctcaaa ggtagtcaag ttgcggttgt tgaccccgat aatctcagca
    15841 ccaagtctgt gggctacctc tagttcagct agattgtgag tctccactaa gacttccaga
    15901 ccaagctctg tcgcgtagtc atacagttcc ttgaggcgtt cttcggacaa ggctgccaca
    15961 ataagcaaga taactgtcgc acctgcattg cgagcgcgga tgatttgctt ttcatctatg
    16021 ataaagtctt tgttgagcgt cggaatctct acctgactgg aaatttcccg tagataatcc
    16081 aaatgccctt taaagaaaac ctcatctgtc aacaccgaaa tcatcactgc tccgttttct
    16141 tcataagtct gggcctgttg cacaatatcc acatcgagat tgatatctcc caaactaggg
    16201 ctagctttct tgacctcagc gattacctgc aagcggtcct gatgattctt caaaaattct
    16261 gccaagcgat aggtctggcg cagaggctgg atttgctcca gcttcatctg ctccacctca
    16321 cgcgccttct gctccaagat tcgtgctaaa aattcctgac tcatttttgg tactcctgta
    16381 acagtctgag tttttcaagg gccttgcctc tagcaatcac ttgacgggcc aaggcaactc
    16441 cttccttgat gctatcaatc ttaccattag catagaaacc aagaccagca ttcaagactg
    16501 tcgtttccaa gaatggactt gcttcgtttt tcagaacgct aagcaaaatt tctgcatttt
    16561 cctgagcatt cccaccacga atatcttcca tagcatagcc ttccattccc aaatcctctg
    16621 gagtaaagct tgacaagctg atttcgccat tttcaagaag tgcaatcttg gttgttccgt
    16681 tcaagccagc ttcatccaac ccttctggtc cagcaaccac gatggcacgt ttgcgaccca
    16741 tatttttcaa aacctgagct gtactttcta ggagttctgg acgactaatt ccaagaagct
    16801 gtgtttctaa agccattgga tgaatcagtg gaccagtcaa gttcataatc gttggaattc
    16861 ccaattccaa acgagctggc atgatgtatt tcatagctgg gtgcatattt ttagcgaaga
    16921 gaaagacgat gccagtttta tcaaagacct tacctagttc agctggtttg aggtcaagat
    16981 tgattcccaa ggcttcgagg acatctgcgg aaccagattt agaagaaatc gagcggttac
    17041 catgcttggc catgtgaata ccgccaccag ccaagacaaa ggctgcagtt gtggaaatat
    17101 taaaactgaa agacttgtcc ccacctgtac cacagttgtc catagcatca tgaatctcag
    17161 ttggaatatg ctgggcatgt cctctcatga ctcgggcaat ggctgtgcgt tcttcaggtg
    17221 tttccccctt catcttaaga gctaagagga gagaagcaat ctgcgcttca gttacacgcc
    17281 cagttacgat acgctcaatg acatccgtca tttccacacc tgataaattt tcaaattttg
    17341 ctagtttttc aataatctct ttcatcctag tttcctcact ttacaacctt ctcgataaaa
    17401 ttccgaatag aagacaagcc gtctggcgtt ccaatgctct ctggatggta ctggaagcca
    17461 taaatcggta ggtttttatg ttgaatcccc atgatggctt ggtcatcagt cgaacgagct
    17521 gtcacttcaa agtcttctgg catttcctca atcaaaatac tgtgataacg catgaccgca
    17581 cggtcatcct caataccttg atacaaaaca gatggcgctt caaagttgat attgctctgt
    17641 ttcccatgca tgacttttgg agccaaacct agcttaccac caaagacttc tgcaatggct
    17701 tggtggccta aacaaatccc tagaatcggc ttcttgcctg caaagtcacg aatcatgtct
    17761 tccatctttc cagcatcaac tggccaacca ggaccaggag aaaagaccag accatctgct
    17821 ttttcagctt cttcatacag cttggaatca tcatttctca gaacctgaac ttctgcaaaa
    17881 ttcccaatgt attgggccaa gttataggta aaagaatcat agttgtcaat caataaaatc
    17941 atggtcttag ttctccaatt ctagtcatag attttgcttt gttaatggtt tcttggtatt
    18001 cgttttgggc gatagagtcg tagacaatcc ctgccccagc ctgcacatag gctctttgat
    18061 ttttgagaat tatggttcgg atggcaatgg ccaaatccat atcacccgtc gcagacaagt
    18121 agccgattgc tcctgcgtat acgccccgtt tttctgtttc cagttcatag atacgtctca
    18181 tagcacgaat ctttggtgct ccagaaacgg ttccagcagg aagtgtagct ttcaaggcat
    18241 ccatggcagt gagttctgca agcaaacgcc ccttgaccac gctggtcaga tgcataacat
    18301 aacggaagag ctccacttcc atatacttag tgacttggac actggtcgtt tcagagatgc
    18361 gaccaatatc attacgaccc aggtctacta acattcgatg ctctgctgtt tccttctcat
    18421 cagagaggag gtcagtcgcc aaggccttgt cttcttcatc cgtagcccct cttggtcgcg
    18481 tccctgcaat cggattggtt gtcacgatgc catttttgac agaaaccaaa ctttctggac
    18541 tggctccgat gatttgataa tccccaaaat catagaaata aaggtaatta gaaggattag
    18601 tcacgcggag atttctgtag aagtcaaatg gatttccagt aacctctgct gagaagcgct
    18661 ggctgagtac gcattggaac atatcaccgt tacgaatcaa gtcacgagct gtttctacca
    18721 ttccctcaaa cttatgtgga gcgatatgcg gtttgaagtc aagtggtgat aaatccaagt
    18781 cttcaaattc atttggagca ggaatgcgta attcctcaag cacttggttc aaggattttt
    18841 ccaaggcctc ttgactgcgc tcactataaa gtgcatcctc tatgacatgt atcttctcct
    18901 tcttgtggtc aaagaccata tagctctcat agacaaagaa atgcatgtct ggcgtcccaa
    18961 ttgtatcctc agggatttga ccaatttctt cataaagcga aatcatatcg taacccacaa
    19021 aaccaatggc tccaccacca aaagggagct ctgaatggtg ctgactctta tgaatcactt
    19081 cataaaggaa atccaaggga tcccgatcaa tcacttgacc attttgatag agaactccat
    19141 tttcaaactt aatctcaaaa actggattat aggctaggat agaaaaacga gccgtttcct
    19201 tgtctctcgg aatactctct aaaataacct tatgttgccc ctttaagcgc atataagcca
    19261 agattggtga taagacatct ccatgaatga ttcgttccat tgtaatttcc ctttcagttc
    19321 taattctagt tcgtggcgac tgtatgaaaa atccccacgc aaaataactt gcgtgaggac
    19381 gaaattcgcg gtgccacctc aattatagga tttctcctat ctctcattcc tgtctcagat
    19441 acctcctgta acaggctgtg cgataaaggg cactcccttg agaatgatgt tttcttctct
    19501 cgtttcagat gaacccaact ttacagcttt ctctgcttgt tttcagcaac cacaagctct
    19561 ctgtgagaga aagaactgta atttttccat ctattatttt ttagcttcta gtagtctgca
    19621 atcgcagcta ggtccttgcc tccacgacca gagacattga tgaagagatg ttcatctcgg
    19681 tacaccttta tactcttcga aaaactcttc aaaccgcgtc aacgtcgcct tgccgtaggt
    19741 atggttactg acttcgtcag ttctatctga aacctcaaaa cagtgttttg agctgacttc
    19801 gtcagttcta tctgcaacct caaaacagta ttttgagctg acttcgtcag ttctatctga
    19861 aacctcaaaa cagtgttttg agcaacctgc ggctagtttc ctagtttgct ctttgatttt
    19921 cattgagtat tactagcttt tttcgtatta gtccagcctt tttgtttact tttagtagga
    19981 ggcaaggagc tgtagataga actcaagttc atcaaagcga cttaaggccc taataaaaga
    20041 taaaccaaac gacggataga aaaaagccca cacacagaat atacttccgt gtgagggcgt
    20101 tggtaacgcg gtgccacctc aattataaag ggactatccc tttacatctc tgccttgttt
    20161 aacaacaagc tgcactgtaa ggtgtgcgca ccgaattttc attgtttcaa attcattttc
    20221 aaaatcagcc cactttcact acttccaacc acctattcac aatcaccaca ggctccctga
    20281 agatcaaaaa tagttacttt tctgatttgt tgaacttatt ttaatacttt gttttttctt
    20341 tgtcaagact tttttacgat ttttttgaaa atatcattcg aatgtgacca tgtcttcctt
    20401 agatcgaaca tgaacatgtc ccacttctta gaaattggat ccaactcaat agaaactgaa
    20461 tggaggctaa acagaactta ttttagaaca ctccatcttt tccactagga ttttcaagaa
    20521 ttaaacaata ctagaaactc tgtctcctaa caaatttagg agaaacttca acagatgtga
    20581 cactttcccc tttaataatt gctaaaacac cttctatcat ttctttagcc aatttaacat
    20641 aattgggagc aattgtagac aaagctggag tataatactg agaaatagga atattatcaa
    20701 atccaataat agaaatatca tctggaataa gaattccttt ctcatagcac gcacgaatca
    20761 agccctgaac cttttcatcg cctgaaacaa aaataatgtc cggataattt tgggtagtca
    20821 agtgctgcat tgcataagaa taaactgaat caattgtaga taagccataa atgactttta
    20881 aatccataaa gtaattttta tcattcagaa aagaacgcac acctttttca cgatccttat
    20941 taacatggga ttctcctccc ataagcaacc acatattttt aaatttttct tcagttacag
    21001 ctttcatcat atcataagta gcttgaaaat tattattaga tacatagact actccagacg
    21061 tttgagattc accgaaaaca agaaaaggca tatggttctt ctttaaatac tgaattctga
    21121 tatcatctac actttcataa aaaacaataa caccatctac taggctacct gtgcttgata
    21181 taattgaatt actaattgta tcctcctctc caaagtactc aactatagca ttaacaccaa
    21241 attctttaca cgtccgtaac actttatcta acagcgtatg aaaccaaatt aaaggaaaag
    21301 agtcgatttt ttttacagaa atcaatatat ttatagcttc ttttttagtt aaattttttg
    21361 catacgcatt tggaatatac gacaattcct ctataacttt ttgaatcgct tgataagttt
    21421 cttctttaac atttactcca ccattaataa ctcgtgaaac tgtttttgga gaaaaacctg
    21481 ataaacgtgc aatatcataa atagttacct ttttcccatt tatatttttc atttcagtcc
    21541 tccattacga acattctaat attactatac aatatttaat tttttttaac aagagaattt
    21601 agtaaattat ttaagatcca caaattcaca aaattaattt tacaaatatt ctttcccttc
    21661 aaaaaagttt aaattgcatt tcacaccttt atttttaaga atgtttccaa cttcacgaca
    21721 aataaattca tatgagaaaa aactgccata aaattgtaga ttaacttttt cagtaaaatg
    21781 tgtaggattt ataaaaacat ataatagcct gtcaatgtaa cattttaaca tagagttaat
    21841 tttttcttta aagataacat ttgttatcaa ctcatcagga ggtaaatgaa aggcaaacac
    21901 catttcacaa atatcataaa aagaaataaa tttgtatact tgtatcaaac aattattatc
    21961 aaaatattct attttaccta aatcaaaatt gattttataa tctttcataa aaacctctga
    22021 gcaaaaatct actcaaaaat tagatgatta aaacatctaa aaaacaaaag gacaaaaaca
    22081 tctgtccctt tgtttactaa atttcagcta atttcttcga cataaataac acctacaata
    22141 ttagcaattt cttccatcag tcgaagatgt tcaaatctac ctgataattc cagagtaata
    22201 aatgacgcta tttttttgtc cggaacatca aagtattcaa ttctgtcaga attaacatct
    22261 ccaaacgctg ttcttgaatc ggtcattctg ataccatttt ctgcacaata aaccaataca
    22321 cgattataga cttctgtaga tttaaccact atatacaatt caatcatttt agaacgattt
    22381 tgcagatatt tttttagtgg ctggaacatg gatatcacac cccaaacaga aatggctact
    22441 aaaagagctc cctcataaaa acctactcca atagctaatc caattcctgc cgaagcccaa
    22501 atgcctgctg cagttgtcag acctgtaatt ttctttttat ctgtaataag aatcgttcca
    22561 gcgcctagaa aacccacacc tgatataact tgagctccta atcgtgtagg atctcctgtc
    22621 ccaaatttat aagatacgta ttcattcgtc atcataatca aacatgcagc tagacaaaca
    22681 atactataag ttcggatgcc tgcaggctgg gatttgctcc ctctctctaa accaattata
    22741 ctaccaatga ctactgataa aacaatcctg acaactattt caatatttga taacccaaga
    22801 ctagtggctg tcatgattat ttccttactt tacgccccgg tctttgtgtg aagtataata
    22861 ccgttccaga aataatcatc agaacaattg tataaacaaa taccagagct tgtgcattag
    22921 atgttgctgt ttcatcacct gcagatcgaa tcgtaatacc taatggttga gctaggggat
    22981 ggtaaaggaa tacagataag tcgaagtcag ttaataaaga gttaaagttt aaagcaataa
    23041 cagagagaac aaccggtaaa ataaatggaa tgataacctt catcatagta taaaaaggtg
    23101 aagcacccat acttcttgct gcatcttcca tctcatcatc aacactaaat aaaatagcac
    23161 gtaccattct ataagaaaat gggattttta caactatata tgcaataagt agaattacca
    23221 aactacctac caaaatctga ttcaagacaa gaaattgtgg ctgattaaaa gtaaataata
    23281 aacttactgc taaaagtgta cttggtagta accaaggaag tagagcacca tattcaaata
    23341 agaaatcaaa acgagattta tgttttctga caacacgagc aaatacaact gcgagaattg
    23401 ttgctgttgt cgcagcaata atagaataaa taaagctgac caagaatgga gagaatgccg
    23461 cactattact aaagaataag cgataatttt ctaaagtaaa gtttgataat gttaagttac
    23521 ctgtttgaat tgcaactgga tctgtaaatg agtataatac tataaaaatt agtggaagca
    23581 tgaaaactgt gaacaatcca tatgctacaa tgtgagcaat gatattccaa ggcttagacg
    23641 caattttttg ttttttaaga ggcgctttag tcttagagat agaaatataa tttccacctt
    23701 tttctatctt attcatgata gtaagcaaaa ttgtagttgc aatacctaaa ataattgcaa
    23761 gtaaggcagc taaatcacga gaattcccca tccctgcaaa tgtaataatc attggattta
    23821 tagtttgaaa ttctttacca ccaacaatca tgggtgctgc tactgcagat aaaccactaa
    23881 gaaaaaccat aatagtaagt gcaaatagag ttggaattaa ggttggtaac actacttttc
    23941 ggaaaacagt aaatggtttt gctcccatat ttcgagcagc ctcaatagtg tgatagtcaa
    24001 cgcttcgaat tgtatttgtt aaaaacaatg tatgattagc agttcctgaa aatgtcataa
    24061 tgaataagac tgcaccatac ccaataaacc agttagggtc taaagaaggg ataacatttt
    24121 gtaaaaattt tgttatcaat ccataaggac catagacaaa tttatatcca gtcgctaaaa
    24181 ccactcctcc ataaattaaa gaggtcatat aacctaattt taaaatttta gcacctttaa
    24241 tatcaaagta ctctgtaaat agaacacaaa gaatacctac gacattaact gtaataatga
    24301 gtgaaaatgc taacttaaaa ctgttcataa tactctgaag tgccctctga gattttagaa
    24361 cacgatgtac agcatcaagg gaaaattctc ctccttttac aaatacattc actactagat
    24421 caaagtttgg ataaataata aatgttacta agaaccagat taaccctaaa cgaataagcc
    24481 aatcttttaa atttaattta tgacgcatac tgcacctcct taaaattgca gaacgtctga
    24541 tggtgtgata aataattcca cactttctcc gacagatcta atagcagcct gactatcaat
    24601 acttgttaca ttaagaatct gattttcaga aacttttatt gtatagtgaa ttgtaactcc
    24661 agaaaactca acatcaataa tcgtcccttt tagaataaaa tcttgttcag tttcacgatt
    24721 gaatcgaact ttctctaatc gaatgtatcc ttttttatct tctaagaaaa cgcttgtatt
    24781 tttcagtaat acttcgtgga ctgtttcatc ggtcaaaaca ttaatatctc caataaaatc
    24841 acatacaaat tcagtttgag aattatgata aatctctact ggtgtaccga cctgttcgat
    24901 gtatccattg ttaaagactg caattctatc agatagagtc aaggcttcct cttgatcatg
    24961 agtaacatat aaagtagtaa tacctaactc tttttgaagt cttttcaact cttttctcaa
    25021 atctacacgt aattttgcgt caaggtttga caatggttca tctagacaaa gaattttagg
    25081 ttcaagaacc agagcacgag ccaacgctac cctttgttgt tgacccccag ataattctga
    25141 tacattacgc tgtaactgtt gatcagagat cttaattttt gctgctactg ctgatacttt
    25201 agctttaata acatctggag ctaccttctt aacttttaaa ccaaatgcaa tattatcaaa
    25261 aacagtcata gttggaaata gagcataaga ttgaaataca ataccaattc cacgcttttc
    25321 aggttccaaa tgagtgacat ctgttccatt aacttcaata cttcctgatg atggatctag
    25381 aaaacctacc aatgctctca aagtagttga tttaccacat cctgaaggcc caagaaatgt
    25441 aaaaaattcc ccttcatgta tatctaaatt cagattatca attgcaacaa aatcaccata
    25501 tttaatttga atattatcaa atttaatcat ctcactaact ccctctatta ctaaaccaaa
    25561 agcctctctt tatttcttct ataaatttag aaataataga gagacttgga cataaaaatt
    25621 aactcttatt tcttattgta cgtattctaa ttcagctttt tctacccatt catccaaatg
    25681 ttttccaaca gcttcccagt caatattttg tggtttcact tgatcaacaa attttttcgt
    25741 atcttcaggt aactctgtta gggcatcttt atttgcagga atagatccaa agttcttact
    25801 atattctact tgaatttctg attgaccaaa ccaatcaata aattctttag ctaacgcttg
    25861 ttttttacta gtgcttaaaa ccatagtttg ttcagttaca aatggtacac caatctcagg
    25921 agtcataact ttgaaaacaa cattttgttc tttttgtcca actaatgcac cagaacccca
    25981 catcataccg tattggatag cgttttcttt gtctaatact ttaacagctg tgctttcacc
    26041 tttttgtagt gtataggcat ttgcaaagta ttcttttgca acttcccagc ccttttccga
    26101 tactcctaaa tcaccttttt catcaagata acgaactaga atacttgcgt aaatggcgcg
    26161 tccagtccca ccagttaagc cataaatgga atattgtccc ttatatttac tagctaactc
    26221 tgtccagtct tttggcattt cttttgcatc aggagctcca atcaatacca agggttgaac
    26281 aataactggg ttataataat tatctttatc tgataaagat tgatcaattt tatctaacca
    26341 tttaggcttg tactgtacta gtaatttttg atctctaatt ttatttgagt caacagcacc
    26401 aattccaaat accatatctg caactgcatt attcttctca gcaataacac ggtctgctaa
    26461 ttgagcgcca gcaatatcaa ccatttttat attaaaacca gcttcttttg ctttagcagt
    26521 taaccaatca ccacgaccat ttgagactga gttcgaatag attactaatt cttgactttt
    26581 atcagctttt tcttcagatg aagaagcagt cgtagaattt gaacctccag agcaagcagc
    26641 aagtgtagta agagcaactc ccgttgcaag tacagtagac caaactttca tttttttcat
    26701 gataagttct ccttttttat tattttattt aaatttttcg tgatatggaa caaattgtct
    26761 catatcttca aatacagtat agtcaatacg gtttacagta atagttggaa tcttctctaa
    26821 taaaatttca gttaattctg ctctgacttt agtaaactct tcttcctcct cttcggttag
    26881 aggaatccga agatacccaa ttgaaatatg gaattgatat ctatcatgat tagggaaaca
    26941 aacacctgct ttttctgaga cataagtacg aatttcttct aatctctttg cagaagcttc
    27001 atctgcaggt tcaactagta tgttttgttt tcccatttca gttatacgca tatgaatttc
    27061 ttcatccaac aatggaaaaa tttcaagttg tttagcaaag taatcatgta tttcctgtaa
    27121 aggtgtatct agaggaagat tactgctcca aaactccgtt tcacgatttt catggcacaa
    27181 caattcaatt acagtcatgt gaatagaatt ccttggagtt aaagtaaact tatcgataaa
    27241 tggtaattct ctataacgtg attgaataat atcaacaact tccatcaaat cttgtttagt
    27301 ataaagattt gctacaactg tattcccagg gaaatgatta aattccccat tctctttgaa
    27361 cttaattttt gttaagtttt tcatataaag accttctttt ttatatttga catcggtgtc
    27421 atcgtattta cattatacaa tgaaaccgtt tcctttgtca agcgcttgca aacatttttt
    27481 taaatttatc tttcattaaa tatgcatttc attaaaaggt taagtaattt tttcaaaata
    27541 cagcactcat atagacagta tcatcaatta tagccattgg gattttttga ttgccaattc
    27601 catgtatctc tacacatgtc ttcaatcgat tttgttgtcc tccaatttaa ttccttatat
    27661 gctttgtctg catttgcata acaagttgca acgtctcctg aacgtcttgg aactatttta
    27721 taaggaatag ggatcttatt aacactttca aatgtattta caagttgtaa tacactagtg
    27781 ccttctcccg agcctaggtt atagatataa acatctgttt tttcagatac tttttctaaa
    27841 gcttttatat gtcctattgc taaatctact acatggatct tttatctcat ttttcccttt
    27901 ttcaaataag ttatctactc tatgatcagt tatttccatt tcgtttacta acatgacgca
    27961 gtcacctagc atcatatact ccaacttttt ttctgaaagt ttagcaaata taaaagcaaa
    28021 tattggtaag cgataatata gtatattgaa actagaatag tacacctctg cttctaaaac
    28081 attgttagaa atcgatttga ctgtcctgat tgatttgtcc tattattatt tcattttact
    28141 atactctgtt aattcatatg agtttaaacc gatttcatct ttaacctcga gtaaagcagt
    28201 ttcaaatatt tgtttaagag tttttgattc tttacaatta accgacaaac tttttgataa
    28261 aatatgtaca acttctgaga ctgaataacc tatctcctct ttagaattat ataaatctgt
    28321 agctccatca ataatcccaa aatactgatt ttgtgaacct acagtatcct cattttctac
    28381 ggaacttcct tgtatcgaac aaattttatt tatctttacc ataatacttc aaccctttta
    28441 gtgtcaaaag taaaccaatt cctgtcactg ttaagaatag ttccataatc ttgttcgaac
    28501 cagtctttgg taatttttgt tttacatcta ctatttcttt agatttatta atatgatttt
    28561 cagtttctct gccatctcca actattttat agtttacttc ttctgtctta ttatcttgtt
    28621 tattgtcgat cttgtcattc atttgtctat tatctttact tgagttaaac tctccgttct
    28681 tctggttact atcaattaca ttatttgaat tagattgttt ttcctctttg tttttttctt
    28741 tttcgttttt atcacttaag ttatttgtta caattttgta aagcccattc tccgttacaa
    28801 tattgaaatt accatcgcta tcacgtataa caggctcttt ctcatttgca ttagatttga
    28861 tgaatgatat atacttaccg gataaattat aaaattggtt atttaaaacg gttattttac
    28921 cctttgaatc ctcaataaca attccttctt taccaccgaa tatactattc tctgagacta
    28981 ctaaattatc actaactcgt aataattcaa tatttggttg ttctgtttcc ttagaattat
    29041 tattaattac attttttgtt acagtaatat ctgatacttt tcctaaatat tctgcactat
    29101 cttttgcaac tcgtatcgct tttgttttag gatcggcaat attaaatata ttttcggcga
    29161 taaccacctg tttatttaaa tctaataggt ctttagtgtt tttatagcta taagcattta
    29221 ctaaagctgc tccgttttct cgataatgta cactctctcc tttaactttc ttatcaaagc
    29281 gatttccttt gattaataca tcagtgaatc ctgtaaaacg tacacctgca tacatcatgt
    29341 tatcaaaatg attatttaaa attttaatat tagaggggtt ctgtgtcgac aatgtttgat
    29401 agtgtgtgcc aattgctgtt actaattccc cagatttatc acttttgcca aaataggaat
    29461 tttgaatagt cacattttca gattttttcc catcatcatt caaggcataa ggaaaacctt
    29521 ttctagttaa tggttcaatc tgaatgctct ccttacttat gatttgccca tccttcatcg
    29581 ttttgggtaa ggcttgccca agaaaacgag aattatcaac taatacattt ttcgaacctg
    29641 caatttgaat agcatgccct tgataactat ccttgaatgt tacatttttt atagttacgt
    29701 tatttgaatt cccaatagca aatgcacctg aagaatttat aagtggtaga ttttttgctt
    29761 tagttccttc ttcattcaaa gcaccgttca tatcaatcgt accaccagaa taactaatat
    29821 cttctgttgg gccccattct acttgcgcac catcatccgt aaataaacct gtcataaaaa
    29881 caatggaagg gtgattctta atatttatac catttagaat tgtagctttc tcattcaatt
    29941 ctaagtgtgt atgacttttt aaaaaaacaa tttcttttac taaataagtt ccttcaggaa
    30001 aatatacatt tcctccacct agcccttgag ctgcagcatc tattgcatct tgaattgctt
    30061 gtcgatcatc atgaatccca tcacctaccg caccataatc ttttacactt aaagcagtat
    30121 cttcaaattc ttttttgata attctgtcac ttataacatc ttccttataa ctcttatttt
    30181 cattagtaga tgttactgta gattcaactg ttctgttgtc taattgtgaa ttggaacgaa
    30241 tagtaccatt agagctgata ctattaacac ttaacgaatt atctaaacca ttagtggttg
    30301 aattagaggc aatcatttca gcagaacgat tttgattaac agttggtgaa ttatctaaat
    30361 cattagtaat tgcattagaa gactcttttg tagccatcgg tgaagaacta gtaacaactt
    30421 catccgataa aataccttgg cttcccaaaa ttgaaattgc caatagtacc gagcaagtcc
    30481 ccacctttaa tttacgaata ctgaatacct tattaggaac aaaatatttc atcagaacct
    30541 ccaatttttt tactattttt aacaattgat tattactttt cttaaaatag atagaatgac
    30601 accgctgtca ttatctttat catatatttt ccaaattgaa ttgtcaagga ataacacaag
    30661 aaaatattaa aatttatact cttcggaaat ctcttcaaac taggtcagtg ccgccttgcc
    30721 ctaagtctag gttactgact tggtcagttc tatagtagac tgaaactata atagtacacc
    30781 tctacttcta aaacattgtt agaaatcgat ttgactgtcc cgatcgattt gtcctattct
    30841 tatttcattt tactatatct acaacctcaa agcagggttt tgagctatct atggccaact
    30901 tcctagtttg ctctttagcc ttccattcaa aagtgatgct atctttctta gcttgaatat
    30961 aaaatatccc atttactata tttaaatttg ttgatatgtt gtaaattata aatgaaagaa
    31021 caaatatctt gtcatacaag cattcgccag ggatatttac ctgaatatcg ctcatatggc
    31081 ggattgaaac taaaacacta caatatattt cttaaataga ccttctataa aagctagatt
    31141 taacctcgat aaaaatagat gcagtgcttc taaaatactg gaatagggca tataggtaat
    31201 cgtagacaag tgttttatag attgtctcgc gggagatcta atgatgtata gcaagcatca
    31261 ctaaacatat agaatatttg tattattata atatcaatat gctataaatt ctatcatgca
    31321 aaagaatgac tagaacatga aagacaggca caaaactttg aacaatattc tgaaaacaaa
    31381 aaaagacgcg agtttccaca atctcactca tggaaactca cgtctttcaa aaaatagggt
    31441 gaattgaaaa ctagaacaag acactagatt ttctaaatga tgtctagtaa ggattctaaa
    31501 tgctacacca aattgctcac atcttatttc aaaccacggg actcccacaa gaaaggaaaa
    31561 tcctataaaa attctctctc tgaggagaaa ggagcctcaa ctacaggtgt aaactattat
    31621 caattgaaaa caacagtttt tacactcaat tagacttttt agggacagga tcactttcgc
    31681 ttgactgtag tttgtcattt ttttgataaa gttagcactt tttcagaaac tgttttgaaa
    31741 gtctcaatga tatagtctac ttcttcatcg cttaatttag tatgaagagg gagggtaatt
    31801 tcattctcaa agaaggcata ggccttagga tagttcgtca tatcaaatcc aagattctta
    31861 taggctgtca agagaggaag cggtttgtag tgaacattac ttgcaattcc tgctttagcc
    31921 aattcttgga tgatgaggtt gcgttcttct aggtttgctc cttctacacg ggtgatgtag
    31981 aggtggcgtg aagattcgac agtttcagtc ttgtgtgcca aaggatggat gcgagaacct
    32041 gcaaaaccac tatcatagcg gtccacaatg tccttacggc gttgcaacaa acttggatag
    32101 cggtccaatt gtaccaaacc aagtgaagcc atgatatcgg tcatgttgca cttataggct
    32161 ggtgtaacga tatcgtattc ccatgacccc aattgcatct tggcaagagc atccttagtt
    32221 tgcccgtgaa gggaaaggat ttggaattcc ttgtacatct cttcgtcatc aatcactgga
    32281 ttggctttcc aagtcgcact tccaccttct gccgttgtaa agttcttaac ggcatggaat
    32341 gagaaggaag taaagtcagc gatagaacca gaaggttgtc ctttataagt agatcccaaa
    32401 gcgtgggcac tatcagagac aatgacaata cggttaaagg ccttttgcca cttgcttgaa
    32461 gcggtaaaga agtcacgttt tttctccacg acttggaaca aacggtcata atcgcaaaca
    32521 atccctgcga gctctactgg gataatcacc ttagttttct cagtgatagc ttgctcaagc
    32581 aggtcatagt ccatctcaaa cgtatctgct tggatatcca ccatgacagg ggttgctccc
    32641 acgtgcgtaa tgacactaca tgaagccgta taggtcatgg ctggaacgat gacttcatca
    32701 ccaggtccca cttccaaaac gcgtaaaatc aactccagag cagctgtcgc agagttgaga
    32761 caaacagtct taggtgtctg tgtgtaaaga gacaagcggc gctccagttc ttttgtttta
    32821 ggacctgttg tgatccaacc agaacgcagg gtatccgcta cttcagcaat ttctgcttct
    32881 gtgatatcag gcggtgaaaa tggaatattg taatttggca ttgatttgct ccttttatct
    32941 gtactcattt tcttatgact actttatttt agtacctcaa acacggtttg aaacatgatt
    33001 ttgatgtccc caaagaaact aaactctcgg agataggcga ggttatagcg catcttttca
    33061 ggaagaacat gctccacata ggcctgatca actgacagac ctttctccgt catttgactg
    33121 atgatggtgt cctcatcctt gtagttgatg ctggctggag aggtaattcc tgcttgcaag
    33181 agcagggttg ccatcatttc agggctatac tgctctgtat aacgtggcac ttcaggtcgt
    33241 gtaccgacaa aggacatctc acctttaagg acattgacca actgaggcag ttcatccaaa
    33301 cggacacgtc ggatgaaatt tccaaccttg gtaatacggc tatcgttagc agaagtcacc
    33361 agacttcctt ttttatccgc atccgtcacc atggtacgaa acttccaaat cttgaaccga
    33421 cggttgtact gggtcacacg ctcttgcttg taaatcactg gccccttgct atccaacttg
    33481 atccaaatgc tcaagatgag aaagatggga gaggtcagaa ccagtaagat caaggccaaa
    33541 acccagtcca agcaacgctt gaaaatcagc gaacccttcc ttttagagac aagctggtag
    33601 taagactcaa cctcgcttga tttcatttcc acaggcaagt cttcccattt cagcatgctg
    33661 ttctcctttg tttttattat actatttgtc aacatttttc attataccac aaaatggaaa
    33721 aggcggtgaa agaaatctgt aatttgaagg atttccttct agtactcaat gaaaatcaaa
    33781 gtacagcttt gagattgcag ataaagctga catggtttaa agagattttc aaagagtatc
    33841 ggccatggcc cctgcctgca aactatacat cttgtgatag gttcctccca gagtcaagag
    33901 ttcctcatgg gttccactct cgataatgcg tcccttatcc aagacataga tgcagttggc
    33961 gtcttgaata gtagaaaggc ggtgagcgat agcaatagtt gttcggccct gtctcatctt
    34021 cgccagagaa gcttgaacca agctttctgt ttcagagtca atattggctg tcgcttcatc
    34081 caaaatcagg attttaggct ggctggcgac tgttctagca aaggcaagaa gctggcgctg
    34141 cccagtagag aagctcgaac cacgctcgga aacaggggag tcgtacccct gaggaagttc
    34201 ttgaataaag gaatctgcat ccacaaaggc tgccgcagcc tgaacctgct catcactgat
    34261 ttcttggtac atggcgatat tggacttaat agttccatga tagaggaagg gttcctgtaa
    34321 gaccaaaccg atgttttttc tcagctcttc ttgactgaaa tccctgatat ccacatcatc
    34381 caagagaact ctccctgact ggaattcata aaagcgcatg aggacattga taatagacga
    34441 tttccctgaa cctgtatgac ctacaaaggc aatggtttca cccttattaa cagagaaaga
    34501 aatgtcatcc agaatcggat gtttaccgtc atacgagaaa cacacatgtt caaaacggat
    34561 attgccttct ttgactttag cctgcccatt ttcttgaagg ggctcatagg tcctctcatc
    34621 gattaaggca aagacacggc ctgcagaaac catagacgtt tgcagtgttg aaaagttttg
    34681 cgtcacctca atcaaggggt caaagaggcg gttgatgtac tggataaaag catacatggt
    34741 cccggccgtt atcccgatag aaagaccacg gtagccaaaa taggccacca agacagcata
    34801 acctagaagt ttcaacaaac tcatggcagg tctcaaaaag agggcatcca aggctacaga
    34861 acggttggca tagaccaagt gctcttggtt gatttcatca aattctgcct gcaggcgctt
    34921 ctcttgatta aaggcctgga ttattctgat tccctcgatg ttttcagcca gcttgctatt
    34981 gatatctgac aagagacttc tggttttctc aatgattttc actgattttt tccgatagag
    35041 attgaccaaa aggaaaatca aggggagaaa gagcaagact aatgctgtca aacgaaaatc
    35101 caataccaac atggtataaa gggttgtcag aaagatgaaa actgctgaga taaagctaga
    35161 taaaatcccc gaaaacatat cactaatcgt ctcggtatcg ttggtcaaac gagaaacgat
    35221 agaacctgct ggcgtcttgt caaagtaaga catgcccagt ttctccatat tggcaaaggc
    35281 atcccgacga atatccctaa caatactgta agacacgcgc gcaaagagaa gattgccgac
    35341 atactgaact acagtttgta ggatgtagag accatagtag accagcaaaa cggtaacggc
    35401 tagttggttg agattgctga gatactggtc gataaagtgg gaagccacga ggggtatgac
    35461 acttttaatg accgtcgtcg ctaggagaaa actgagtgcc aaaaaggtca ggagtccata
    35521 aggcttgaga taagacatca agcgcttcaa tacagcccat tgttcttgtt tattctgcat
    35581 cttcttctcc tttcatttcc aactgctgag actggtaggt ttgggcatac cagccatcca
    35641 aagctagcaa gtcttcgtgc ctgcctcgtt cgataatttg accattttgc aggactaaaa
    35701 tcaaatctgc atggacaaca gcactcaggc gatgggcagt gataatggtt gttttgtcct
    35761 ttcgcgtctc cttgaggttg tcgataatcg catactctgt cttggcatct acggcggata
    35821 aggaatcatc caaaatcaag atatcaggtt ctaaaatcat agcccgactc atagccaacc
    35881 gttgcttttg accaccagaa agactgactc ctttttcacc aatcagcgta tcaaatcctt
    35941 gaggcatgtc tacaatatct tggtaaactc gggctagctt agtagcttcc acgaccgctg
    36001 aaaggggcaa gttaggattg ccaaagcgga tattgtctag gattgaagtc gcaaagagaa
    36061 actggtcctg aggaacatag cccatgagac tgcgaaggtc tgtcagacga tagtcccgaa
    36121 tatcgtgacc gtttagataa atagtaccct tatccacatc gtattcacgc aagaggagct
    36181 tgattaagga cgttttccca gagcctgtct gcccaaccaa gcccagtgtt tgcccttttg
    36241 ccaaactaaa gtgaatatcc gtcagtgttt cctcattttc aaaagcaaag ctgtcaatgg
    36301 catactccaa acgcccattt tcaataccat ccagaggaaa ctcagggtct tgtacaggag
    36361 attcctgaga caaaagattt tcaatccgct ggtaagaaac cttccctcgc tgagtagtat
    36421 taaagaggaa gccgatggcc ataagaggcc agaccagcat atccaaatag ctgataaagg
    36481 tgactagatt cccaactgta atctgccctt cctgaaccat caaggagcca accaaaagcg
    36541 ttaaaacata ggacgaacca acaaacaaga gaaccatagg gtcaaagaga ctatcatatt
    36601 tcatggtttg caggttcttt tggaaggtta attcattgac tgcctgaaaa gacttcaact
    36661 cgtctgcctg ataaccgaaa gacttggtca ctttgatacc tgatacggac tcctgtacct
    36721 tgttattgag ttcagaaaaa gcagcttggg attcgccaaa ggccttatga gtctttctcc
    36781 ctaggcgact agtcgtatag gccatgaaag gtagggggag aatggcaaca agagtcatct
    36841 gccatgagat gctaaagagc atggtcaaca aagtcaccag agccgtgata gaggcatcca
    36901 ccgcagacat gacaccgcca cctgctaaac gagtcaaggc attgatatca ttggttgcgt
    36961 gtgccatcag atcacccgtc cgataggttt gataaaaggc tgacgacatt tttgtgaaat
    37021 gcttaaacaa gcgagaccgc atgatctgtc ccaagcaata agaggtccca aggatataca
    37081 tacgccacac atagcgcaaa tagtacatac caaatgctgc aagtagcaag taaaataggc
    37141 taagaaggag gtcctgctgg gttaattgcc ccgatgtgat ggcatcaatg acccgcccca
    37201 taaccatagg aggaatgaga ttgaggacgg aaaccaagat cagggccaca attccgacta
    37261 gataacggcg tttttctaac ttgaaaaacc accaaagttt ttgaataatg gacataaaat
    37321 ccctttctga ttgcaaatgg aaacctgagg ccaatactca atgaaaatca aagagcaaac
    37381 taggaaacta gccgcaggct gctcaaagca ctgctttgag gttgtagata gaactgacga
    37441 agtcagtaac ctacatacgg caaggcgacg ttgacgcggt ttgaagagat tttcgaagag
    37501 tacaagaccc caggtttttc ttattcataa gttacgactg taacagcacc cttgtcatat
    37561 tcagcaataa agatattggc tacattgtca tgcccttgtt tactgaggtt atcaagcaac
    37621 cactcttcgc tacgaccaat cgattccaag acatctactt gaatcacacc gtcagtcaca
    37681 actggatact taggattttc atctcccatt tgcacaacga tgagttgccc attttgctct
    37741 tgcacagctc gtttgacttg cttcatctgg aaaatccctt ggctacgaag tttgagggat
    37801 acatccgatg cagacaaacc aactgaacga caggcttctg ggtcaatatt cccatttttg
    37861 ataaggagag ttggcttacc atcaatcaaa cgtttcacaa agtgaacatt gttgttgagc
    37921 tatttgagag tcaagaccag tttgattaaa atttcgatat aattaagtgt catttgttca
    37981 catccaccag ttcaattgcg tctgtcttat acaattcgac tttctctaac aggtacttgt
    38041 ctggctcact tccgtttagg gcacgataat agcgatctcc caccttgata agtgcgccat
    38101 ctgtgtttgt ggaagtatta acatagactt ctgacttgtc tactcccaaa tctttggaaa
    38161 caacctcgat gaaatgaagt gaagtttgaa atttattgtt agaaacttga ttgttttgat
    38221 aagtcgtgat gctgaccaaa agcagagcta aataaggcca gatctgaaat catgaccaac
    38281 tcacgaaatt cgcttccctt tttattatgg tatgccttga aagcaaaaaa aactgtcaca
    38341 gctaatagaa caatcccaaa gccaaccatg ataccatttt gctgaccgat ttggctgagt
    38401 acatagtcat aagagtagaa tttcatgtat tttcactccc tttcataaaa tcattcttaa
    38461 ttataaacga aagagagtaa tttttcaaac catacgttgg ggaaatagat ctttttttgg
    38521 tataataaaa tctatactct gaatgaaaaa ggtaacttta tgaaacttat ctcatggaat
    38581 attgattccc taaacgctgc cctaactagt gactcagctc gtgccaaatt gtcccaagaa
    38641 gtcctacaaa ccttggtcgc tgaaaatgct gatatcattg ctatccaaga aaccaagctt
    38701 tctgccaaag gacctacaaa gaaacacgtg gaaattttag aagaactctt cccaggctac
    38761 gaaaacacgt ggcgctcttc ccaagagcct gcccgtaaag gctatgctgg aaccatgttc
    38821 ctttataaga aagaacttac acctactatc agcttcccag aaatcggtgc cccttctacc
    38881 atggacttgg aaggtcgtat catcactcta gaatttgatg catttttcgt aacccaagtt
    38941 tacactccaa acgctggtga cggtctcaaa cgcttggaag aacgccaagt ctgggatgcc
    39001 aaatatgctg agtatttggc tgaactagac aaagaaaaac cagtccttgc gaccggtgac
    39061 tacaacgtag cccacaatga aatcgacctt gcaaatcctg ctagcaaccg ccgttcacct
    39121 ggatttactg acgaggaacg tgctggattt accaaccttt tggcaactgg atttacagac
    39181 accttccgcc atgttcatgg cgatgttcct gaacgctaca cttggtgggc acaacgcagc
    39241 aaaacttcta aaatcaacaa tacaggctgg agaatcgact actggctcac aagtaaccgt
    39301 atcgctgaca aggtcactaa atctgatatg attgactcag gtgctcgcca agaccataca
    39361 ccgattgtct tggaaattga cttgtaagga ttttctatat ggactacaat gcggtcattc
    39421 ccgagttgct tgtatcgaat atcgaacagt cccggtcctt ctactgtggt ttactgggtt
    39481 ttaggattga ataccaacgt ccagaagaaa actttctctt tctcttgaag agtgtcaact
    39541 aatgttagag gagggaacaa aggatcaact agctgaactg acctatccct ttggtcgtgg
    39601 agtcaatctc tcctttggca taaaggatgt ttcaaaactc tattaaagag tgatgaaggc
    39661 aaactatcct atttatcgtc ccttgaccaa gagaaagttt cgtgtcagtg atcactatat
    39721 ctatcctcat gaatttgcag ttttggatcc aaatggctat tttttaagat ttagcgagta
    39781 gaataataaa aattgggaaa agtctttaaa gttagaaaaa ggcatattgt caggtgtcta
    39841 aaaacttgat agtatgcctt ttatgatgga aaaatcttct aatactcttc gaaaatctct
    39901 tcaagccaca tcaacgtcgc cttaccgtag gtatatgata ctgactctgt caattctatc
    39961 cacaacctca aaacagtgat ttgaggttgt ggatagcttc ctagtttgct ctttgatttt
    40021 catttagtat aaatgttagc ttacaatgga gtttttgttc accctctctt ctgtttgttc
    40081 gttttttaaa ccaaaacact aacaaaatag ttggtttcta aagttattta gtgtaaaata
    40141 aaaacattgg ctcaagccta tttaaaattg aatatcgttt tacttgttta tgtcgtgaat
    40201 tggcacgacg tttctacaag gtgccggaac acctaacaat aagtaagtca gcagtgagat
    40261 atggccgttt ttgccatgtc tatttagggg acttacttag agattaagta ggtctttttt
    40321 gaatattttt aatatttccc ttaattagtg cggacgggag gtgaaattat cctgtgaata
    40381 atttcaggaa tccagggaat ttcatcccta atttttgagc ccctagctct ttcatttcta
    40441 ggcttaggct aaaatagttc cccgaactat tttactctca aaaatcccgt catagacaat
    40501 aacaagatta ttgtctatga taccactaca tcgggaaata tttgataaga ctcgcttcgc
    40561 tcgtaatagt tttatcaaat atatagtatt agcaaaaggg atcactatag aaacatttaa
    40621 acaacaagta aattaacttt tagactttag gaggtcttat gaaattatta gaagagcgca
    40681 tcctcaagga tgggcatatc ttgggcgata acatcctcaa ggtagattcc tttttaaccc
    40741 accaagttga ctttagcttg atgcgagaga ttggtaaggt ttttgcggaa aaatttgctg
    40801 ctactggcat taccaaggtc gtaaccattg aagcgtcggg tattgcccca gccgttttta
    40861 cagctgaagc cttaaacgtt cccatgattt tcgccaaaaa agctaagaac atcaccatga
    40921 acgaaggcat cttaactgct caagtctact cctttaccaa gcaggtgacc agcaccgttt
    40981 ctatcgctgg aaaattcctc tcaccagagg acaaggtttt gattatcgac gatttccttg
    41041 ctaatggcca agctgctaaa ggcttgattc aaatcatcga acaggccggt gctacagtcc
    41101 aagctatcgg tatcgtgatt gagaaatcct tccaagatgg tcgtgatttg cttgaaaaag
    41161 caggctaccc tgtcctatca cttgctcgct tggatcgttt tgaaaatggt caggtcgtat
    41221 ttaaggaggc agatctctaa tgcaaactca agaaaaacac tcgcaagcag ccgttctggg
    41281 cttgcagcac ttactagcca tgtactcagg atctatcctg gttcccatca tgattgcgac
    41341 agcccttggc tattcagctg agcagttgac ctacctgatt tctacagata tcttcatgtg
    41401 tggggtggca accttcctcc aactccaact caacaaatac tttgggattg gactcccagt
    41461 cgttcttgga gttgcattcc agtcggtcgc tcccttgatt atgattgggc aaagccatgg
    41521 tagtggcgct atgtttggtg cccttatcgc atctgggatt tacgtggttc ttgtttcagg
    41581 catcttctca aaagtagcca atctcttccc atctatcgta acaggatctg ttattaccac
    41641 gattggttta accttgatcc ctgtcgctat tggaaatatg ggaaataacg ttccagagcc
    41701 aactggtcaa agtctcttgc ttgcagctat tactgttctg attatcctct tgatcaacat
    41761 ctttaccaaa ggatttatca agtctatctc tattttgatt ggtctggttg ttggaactgc
    41821 cattgctgct actatgggct tggtggactt ctctcctgtt gcggtagctc cacttgtcca
    41881 tgtcccaatt ccactctact ttgggatgcc aacctttgaa atctcatcta ttgtcatgat
    41941 gtgtatcatc gcaacggtgt ctatggttga gtcaactggt gtttatctag ccttgtctga
    42001 tatcacaaaa gatccaatcg acagcacgcg ccttcgcaac ggttaccgcg cagaaggttt
    42061 ggccgtactt ctcggaggaa tctttaacac cttcccttac accggatttt cacaaaacgt
    42121 tggtttggtt aaattgtcag gcatcaaaaa acgcctgcca atctactacg cagctggttt
    42181 cctggttctc cttggactgc ttcctaagtt tggtgccctt gcccaaatca ttccaagctc
    42241 cgtcctcggc ggtgccatgc tggtgatgtt tggttttgta tctattcaag ggatgcaaat
    42301 cctagcccga gttgactttg ctaacaatga acacaacttc cttatcgcag ctgtttcaat
    42361 cgctgcaggt gtcggtctca acaacagtaa tctctttgtc agcatgccga cagccttcca
    42421 aatgttcttc tcaaacggaa tcgtcgtagc cagcctactc gccattgtcc tcaatgccgt
    42481 attaaatcat aaaaagaaat aagaaaaaga ggtgcgagcc tcttttttgt ttatcacaaa
    42541 ttgattataa atacaatcaa tcccaattcc catctaattg aattggacct atttcaaatt
    42601 ctttaaaata ttatgttcca aatcgttaat attatataag aatggtaaaa tatcaaatgt
    42661 ttctcgtaaa ttattcttag ccttatacca accttgtcca tcagtaatcc acataaactc
    42721 aacattagga atagctttaa tttcttcagc aatcattttg taagatctag ccgtctcatt
    42781 taattttgaa ccacttcctg aataaaaatt aacctcaatc agataaagca cttgttcatt
    42841 ttttatgaca aaatcaaaac gtttcacagt attcccatca ttcgtaatag cagataaatc
    42901 gacagaaaaa atttcctcta tttcattttg ttcaatctct ttaaataaat tctctcctaa
    42961 aatataccct tcagcttcaa gatagctttg aacaatattt tccatcgcat ctccagtccg
    43021 atttttgcgc ccattagtat ccataccaac ctcaacacct gtaacgtagt caactaaatt
    43081 tgatactaaa tgattttgca ataaatcaaa tatacctgat ttttccaaaa acatagtata
    43141 ttcttcaata ctatagtttc gtttactaaa atcaaaatag aaatctttta tcggatcctt
    43201 aacaataatc gtatctctca aacgtttagc aataagtaga ggcacaactt tcaaaatttc
    43261 tggataattt tgatataagt ctaaaaaatc ctcttgtata tttttactac caataagact
    43321 attcataata tttagagcaa cttttatact agatacattt ttataaacct taggaaaatc
    43381 tgtataataa gtccagtcag ctactgtgtc ggtcatcgtt gacaaccact catcaaaatt
    43441 tctagtttgt ttcattttct gcctccaacc tcttccttgc aatttttaaa tattcttttt
    43501 cagcatcgat acctataaat cttctaccta accgcttcgc aacaacaccc gtagtgccac
    43561 taccaacaaa tgggtctaga atatagtcac cctctttagt agaggctaaa ataatgcgtt
    43621 ctaacaaata ctctggtttt tgagttggat gtttcccagc ccatttttca actttctttg
    43681 ttaaagaacc ggtccagaca tctttcattt gttttccatc attcaattct ttcattaaat
    43741 cataattgta gtaatgacga gcttttttat cattttttct ggcccataaa atggtttcag
    43801 tagaatgggt aaaataacga caagataaat tgggggcagg gtttgttttc tgccaagtaa
    43861 tattattcag aattttaaaa ccttcttgtt ctaatgccat tccaactgag tatatgttgt
    43921 gcaaactacc tgaaatccat accgtcccat taggcttcag aacttctttt gctaggcgaa
    43981 tccatttacg attaaactca tgtttttctt cgaatgaaga aattttatcc caatctcctt
    44041 tatcaacaga aacaacttgt cccccagaat tagatattcc accattactt aaaaaataag
    44101 gtggatcagc aaaaatcata tccatacttt ctggtttcat ttttgataag aacttgaacg
    44161 tatctgaatg aacaagaatc atcttatttt tattgtagta tggttttgtc ataagaacac
    44221 ctccatactt atattcgtta tttttcataa tttgtgacta taatttcaga aatttttcct
    44281 cgacttgaag attttgctcc attagttcgg gtagcttcaa cataatgtat attaaaatcc
    44341 ttatacaact cctctactaa agcactagaa gaatttgata acataacata agctcctgta
    44401 tcactcaatc tcttaaaggc atctcttaat cttacttgat ctgcaaaaga gaatccctca
    44461 tgagtataag acgtaaatgc actcgtctca gacaatggaa tatatggagg gtcaaaatac
    44521 acaaaatctc ctgttcgaac atctacaatt gccttttcaa aatctcccac tttaatttct
    44581 agttgattgt tatttatata aactgaaata gcagatatca attcctcatc aacaatttta
    44641 ggattcttat aacgtccata tggaacatta aattgattct tagaattcac acgatataga
    44701 ccattaaagt tcactctcaa catatataga atacgtgcag ctctttgtac ttcggacatc
    44761 atatctattc tttcatcacg atctgcagaa cgtaaatcta aataatattc ttttgaatta
    44821 tattcctgat gaactttcaa aatttcaatc aattcttgag gattgtcctt aatttgttga
    44881 tagcaattta ttagttcagc gttaaaatca ttaataactg catctttagg agccaaatca
    44941 aaaaataaag ctccacctcc aacaaaaggt tcgaaatacc tgttataggt tttaggcatt
    45001 aattctctaa taacaggcaa taattgtctt ttaccacctg tccatttcgt gaacggttgt
    45061 aaagtaactt tctttatttc ttttatcttc atgcttttaa ttataccata gaaattaaaa
    45121 cacaactctt gtattttcta ccacattact aaattttcta ttttagaatt aaatcatatc
    45181 aatatcaaaa aatgagtaag gcaaatctta taaattccaa aattcacctc actctattaa
    45241 attactcttt atatccttac ctgtctttct tctgaccgct ggcctgtgac aaacatggta
    45301 aaggttgctt tacagacatt tctgccctct tgattggtga tatccacatc catcacacag
    45361 gttgtacgac cttgatggac acattctcct ttaatggtca atacatcgtc gagttttcct
    45421 gccttaaggt agttgataga ggattggagt gtcaccccat caagtcccag cgagataacc
    45481 accaaaccac tgatttggtc acatagcgtg aatagatagc caccatgggc attgccatag
    45541 tagttgagcg acgagttcac tactttggtc gtcaccacaa cgtgaccatc tctcattttt
    45601 tcaatttcgt aattttcaaa ggcagatata gcgtcaaaat gaaagtcttt catcgtttcc
    45661 tcctgatatt tcaaacgaca ctatgatact actttttata ggactgtgca aggagaaagc
    45721 tcctagtcta gtaaaattcc gacctgttcc acaaagcgca taaaggctgt ctgaccttgt
    45781 tctgtctgct tgtagactcc tgcatcctca agtacacgca caaagatagc acccacagag
    45841 tccttgacga ttgcaagggc tttttcttta tccgttaggt ctggatgttg ggatttgagt
    45901 tggtctgccc actcctgatg ataatcggca actgtaacag cttctcctac aagatagcta
    45961 gcgacttgct ccacttcttc tttcagacgt ggtggcaaga ttgccaagcc catgacctca
    46021 atcaagccga tattttcctt cttgatatgt tggacatcct tgtggggatg atagatgcca
    46081 tcaggatgct ctgctgaagt ctgattgtct cgcaagacca agtccaactc aaactgtcca
    46141 tcacgcttac gcgctattgg tgtgatggtg tgatgcggtg tcccgtctgt ctctgctaaa
    46201 atctgcacac tagaatctga atactgacgc cattcctgga aaatcttatc agctaagtta
    46261 atcaaatcct ctttggaatc cgaagtcaag cgtaggacag acattggcca cttgataatt
    46321 ccagccttga cctgctcaaa accagcaaat cggaaggtct tttgcaaggg agccaattcc
    46381 ataggaaata cgtgacggcc tccctgataa tgatcatgag ttagaataga gccccccaca
    46441 atcggcaggt cggcattaga tccagcaaaa tatcctggaa actgctctac gatagccaac
    46501 agacgttcaa aactctgacg actaatggcc atgggacgat gctggccatc taaaaagata
    46561 caatgctcat taaagtaagc atagggcgaa tactggaacc cccattcctg accaaccatt
    46621 tcaaaacgga taatccggtg gttgctgcga gctgggtggt tgacccgacc atggtaaccc
    46681 tcattctcta aacaaagttg acactgagga taattactag cttgcaccaa cttggctacc
    46741 gcaatctctt tcggatcctt ttcaggctta gagagattga tggtaatttc aagttctcca
    46801 taatcagatg gaacacgata agcgatattt ttagcaatgg ccttgagttt gatgtagtca
    46861 tttttccgac tgagttgata aaaatcctct atcgcttgct caggagagta ggcataagct
    46921 tcccagaagt cacgattgac ctgactcgga caaggagtca ccaagtccat caattcagta
    46981 ccaaggattt cacgcgcagt ctgactatcc tcaatcgtct ctaatcgaac ggcttcctca
    47041 actagctggt ccttgaggtc aatcaattta tccagattgg tctcaacttc caaaacacct
    47101 tctcccactc gtgccaaaac acgattggtc aggtagattc gatccatttc ctcaaatgaa
    47161 ctttcagaaa tgacatgtgt tacaaattta tctactaagg tcactataga gcctcctttt
    47221 gactagtcaa ggacgcgagt gccacctgca acttcagcga tatagaagct tggagcgtat
    47281 ccaactactt cctcgtagtg tttgcctaca gcttccttaa aggcctcaac agtatctttt
    47341 tgaaccaagg caatggcaca gccaccaaaa ccagcccctg tcatacgagc accgagaact
    47401 ccttcttgtg cccaagctgt gtgaacaaga gtatccaatt ccaaaccagt tacttcataa
    47461 tcacgctcca gagaaacgtg tgacgcattc atcaaacgac caaatgtttc caaatcacct
    47521 gcttgaaggg ctgcttgagc tttaagggta cgttggtttt caagcacagc atggcgagca
    47581 cgtttcaaac gattttcatc tttaatcaga tagctatatt ggtcaacggc ccactcgtcc
    47641 aattcaccca gggtctgaat atccaaggca acttgcaatt cttccactgc tttttcacac
    47701 tcagcacgac gttcattgta tttagagtcc gccaattcac ggcgtttgtt ggtgttcatg
    47761 ataacaacga cattgtcctt caaatcaagt ggcaccaagt cgtattctaa agtattggta
    47821 tctaagtaaa tagcacgttg gtcagccccc ataccaatag caaattggtc catgatacca
    47881 gagttgactc cgataaagtt gttttctgtt tgttttccga ttttaaccaa atccaaacgg
    47941 tctagtttta aatcaaagag atgctctgcc acgactcctg tcaagagctc caaggatgct
    48001 gaagaagaca agccagaacc atttgggata ttcccataaa cataaaaatc aaaacctttg
    48061 tcaatcacat gcccagcttt ttgcaagaaa tgaagaaccc cttttggata gttggtccag
    48121 ttgtgctctt tttcaaactt gaggtcagcg agaggcactt cgattatgcc cttgtcctca
    48181 aagttagctg agtagaaacg caagacttgg tcgtcacgct tacgaactgc accgtaagtt
    48241 cccaaggaaa tagcagcagg aaaaacgtgc ccaccgttgt agtctgtgtg ttcaccaatc
    48301 aaattgatac gacctggtga aaagaaagtt tggtctgctt cttgaccaaa aacagcaaga
    48361 aagtctttgc gaagagtttc agcagtaaga tgttgtgtca tatgatttct cctttgactg
    48421 tccgttaagc caccttaacg tgtaatcgtt ttcttctatt gtatccaagg gatttctcaa
    48481 ggtcaatcct ttttactaaa attttagtaa aatatcagta aaaagaagaa aaacatgata
    48541 tactaaccta atcaaggagg atttatggct accttaaaag acattgcaca gctagcctct
    48601 gtctctatcg cgaccgtatc ccgcgtcctc aatcgcgacc agagcctatc tgttacagaa
    48661 gaaaccagac accgtatttt aaccgttgct gaagaactgg gctacaccaa gcacctcaag
    48721 acaggcgagt cccacaaacc caagcaaaag attgccatta tccaatgggt cagcgaacaa
    48781 ggggagctgg acgacctcta ctactaccag attcgcctag gaatagaaaa aagagcccaa
    48841 gagttggact atgatatctt gcgctatttt aatgaccatc cttttacctt aagcgaggaa
    48901 gtgattggga ttctctgcat cggaaaattt agccgagctc agatttctgc ctttgaagaa
    48961 taccaaaaac ccctggtctt tctagacagt gatacacttt ccctggggca tacttgtatt
    49021 attacggact tttacactgc cataaaacag gttgtcgatt atttcctcag ccaaggaatg
    49081 gaccgtatcg ggattctaac aggccttgaa gaaacaacag accaagaaga aatcattgag
    49141 gataagcggc tggaaaattt cagaaactac agtcaagcaa aaggaatcta tcatgatgaa
    49201 ctgatctttc aaggaaactt tactgcccag tctggctatg acttgatgaa ggaagccatt
    49261 cagagcttgg gagaccaact tccgccagca tttttcgcag ccagcgatag tttagctatc
    49321 ggtgccctcc gtgccctcca agaagctaga atcaacctgc cagatcgcgt cagcctcatt
    49381 tcctttaacg acactagtct gaccaaacag gtctatcctc ccctctctag tattacagtt
    49441 tatactgaag aaatgggccg agcaggtatg gatattctta acaaggaagt cctccacggt
    49501 cggaaaatcc ctagcctgac catgctggga accagactga cattaagaga aagtacccta
    49561 aatcaagaat aggataacat aaaaaacgaa taggagtttt agaactccta ttcgtttttt
    49621 attcgattac aatcatagac ttaatggtct tacgttcatc catatctttg taggcttggt
    49681 cgatatcttc cagtttataa cttgaagtaa agacgcgacc tggattgata tcaccatcaa
    49741 ggacggcttt tagtaaaaat tgcttatcgt atgttgtagc agaagctgcc ccacctgcta
    49801 cagagatatt ttgcataaat gtcgaaccaa gagcacgatt attatagtgt gggactccta
    49861 caaagcccat acgccctcca ttatgaagaa cacctagcgc ctgttctata gcagcctccg
    49921 taccaacaca ttcaagtgct gcatctgctc ctccaccgag gatttcacgc acctttgtaa
    49981 ttccttcttg accacgttct gcaacaacag ctgtcgcacc tgactccata gccatctttt
    50041 gacggtcttc atgacggctc ataaggataa tttgtgatgc tccacgcatc ttagccgcga
    50101 tgacagcaca ttgaccaaca gccccatcac caataacaac aaccttgtcc cctttttgaa
    50161 catttgcaac acgcgccccg catgatagcc tgtcggcatg acatctgcaa gagtcaaaag
    50221 ggacttgagc atcccttctg tatagtcaga aggttgacca gggattttaa ccagcgccca
    50281 gtttgcatag tggaagcgaa tatattctgc ctgaaaatca ccccccaaat tattgccaat
    50341 atgattgtcg caagaaccgt caaatccagc aagacaggca tcacactcac cacatccatg
    50401 tgtaaaaggg acaatcacaa aatcacctgg tttcaccgtc gtaatggctt ccccagcttc
    50461 ttcaacaatc ccaatcgctt cgtgtccact atttttgtgt ccagctttcg tttctggatt
    50521 acggtacctc cataaatctg aaccacaaac gcacgaacga accacacgaa taatcacatc
    50581 atccgcttct attatttgcg gacgttcaat gctaacaagt ccaacctgac ctgcctttgt
    50641 atatactgct gatttcattt aaaattttcc ttccttataa agtttaattt tgagatttaa
    50701 acgatttaaa gctgtctgta gctgagacaa gcgctcctct aatttttgct tttcctcttc
    50761 taaaatacca agcctctcct ctctcgtttc atctcccttt tggtagagcg acatatagtc
    50821 aactaaacta tctacagaga cacccgccga acgaaaacac ttaataaatt ccagcgcttc
    50881 gatatcctga tcttgaaaat cacgaatccc agtagcagta cgagtaatcg gtggcacaag
    50941 accaacccgt tcataatacc gaatcgtatc cgctgaaatt cccaacaaat cactggcaga
    51001 tttaatattc acacgctaac ctcctctcat ttcattcact gagttcacgc tattctaact
    51061 cacttatctt attatataac tttgagttga ctccaagtca agcattttgt atctaatcga
    51121 aaaattttta tcattaacaa tcatatatct ggagtttata caatgctctt ctcttaccaa
    51181 tttttgaaat atttaaataa taaagaaatt actctattcc aaataagata gtacccaagt
    51241 atttttcact tttttctaat gttgatgctc ataactccgt tccaagtcac acacctttcg
    51301 cttatgggtt tgatgagttt ctaggtcagc atcaatttca atggtaatat tttgaaaacc
    51361 acaatctttt aggaaaattc gaatagactc tttacaagtt tccatatgtt ccatttcttt
    51421 tagacaaaca tggacaatgg catttttttc caaagcatcc atagtccaga gattaagctg
    51481 attaaggctg gccacattgt ccaatcgttc caggccactc tttacttgct tgatatcaag
    51541 accttctggc acagcatcca agaaaatctt gagtgtagac caaaaacgtg aaagggcttt
    51601 tgaaagaata aagaaagaaa tgacaaggga caaaagagga tctaggatat accagtccgt
    51661 aaatcgaaga acaatcgcca tcaggataac agctacccac cctagcgtat cttccagaaa
    51721 atgcagactc agaatagact cattctttgt ctttccctta ccaaccacca gactcgctaa
    51781 cagattgata gtaatcgcaa taattcctaa ccagagaatc ccctcatcat tgactggttg
    51841 cggatgcaaa atcttcgtga cattttccaa aatgactaga acagagcctg ttacgagaat
    51901 cacagctgtt accaaggctc ctagtaggct aaaccgctta tagcccaagg tgtactgatt
    51961 gtcttcttca cgattggaga ttgtttctag aaaagctgat attccaattg caatcacatc
    52021 tcccaagtca tgcacagagt cagcaagaac agcgctagaa ccaaatactc cacctgcaat
    52081 aaactcaaca atggcataag tcaaatttaa gaaaaaagcc acccaaacag catattttgc
    52141 cttcatattt ctcattcctt tgttataata ggtttatgaa caccttgttc attatcatta
    52201 tccactaaaa ctcaaagaaa ggatagaagc aaaacgtcag ctttattcag ttctgaacaa
    52261 tttgccttaa gtgtccatat gactaacatt gaccgccgta tcagcaaaac caaaaaagcc
    52321 atctatcaag cttttataca acttttgaat gctaagggct acgaggccac tactgttcag
    52381 gatatcattg atctcgcaga tgtgggaaga tccacctttt actgtcacta tgaaagtaag
    52441 gagcttcttc tggaccagct ctgccgctac ctcttccatc atctttttga aagagagcaa
    52501 gccatttcaa ccgaggacta cctcgcccac ctctttctcc attttcataa aaaccaagac
    52561 catatcacca gtctgctatt ttccaaaaat gactacttcc tccgtcaact ccataaagag
    52621 ctagaacacc atgtctattc cgtgctagct gataatttaa aagaagccca ccctaatatg
    52681 cctacttctt acctccaaca cttggtcgtg tccaacttta tcgagacatt gacctggtgg
    52741 ctcaaaaaag gtcaagattt cacagaccag gaagttgtcc aattttatct agaccttctc
    52801 attcctaaaa attgaatata gagtaaagct cagttgtctt atttctaggt tactgagttt
    52861 tttatctttt caacaacaaa agaggacccg ccgatcctct ttttcatact ataaatcctt
    52921 gattatcaac tatatctgtt ttaatcgaaa tctcaaaaca gcactttcaa acatcttttc
    52981 ctagttaagt aaatcagtat tctgcttagc tgccttgctc cattgatacc aaccaactag
    53041 actgttaatg agataaatta gatatttccc ttgaatttgc aggctttctc cccaccagag
    53101 atagattgaa aaaacattgg tagccgccca gaatatccac tgttcacggt aaacagctgt
    53161 catgaggatt tgccctaccc cattggttgc atctgtgatt gaatcacgat agggacgatt
    53221 ggcaccaata gactgataaa tgaagccaaa ggccaaccac caaagcacac taatggaaag
    53281 atactttgtc cagcccttgc cgtccagttt acgcgcgaca aactcctgct tttccttctt
    53341 aaactgtgcc tgataaatcc aaactagaag tccaattggc tgcatgactg tgaagtaaag
    53401 tgtcgtcagc acctcaccat aaaagccttt ctgtagggcc aaaataaggt aaataacaga
    53461 gttaatcaag ccaaaaagat aattacttgc tcgaccttcc gatacaaaga ttacacagat
    53521 aatccctgtc aagctacaaa tcatcccaat ccagtcaaca atacgatgtt cgtaaaccaa
    53581 ctccagccag agaggaaaac ttcctaaaac cagcaaataa atccactggg caaaactacg
    53641 atgggcaaag aggtcatccc agatagcctt catagttcct gaaaatccta aatcagccat
    53701 agccgcaacc atacgacggt aaccacctga catttcacct agggttgttt tgatattttc
    53761 aattttcttt tgcaaataag tatgcatcat ttctcctttt gtttttaaag agccgtgtct
    53821 ggatagactt tcggacgcaa cgctctatta gataatgaac tgcctataca caagatttct
    53881 aaccttagtc gacatgagct gaaacctctt atttgttaag tagttcacaa aatattatac
    53941 acctatttta tgaatagtca actgtcttta cagtaaaatt ttagaaaatc atgaaaattt
    54001 tctctttctt tccattttaa gtgacattca gtcattctca catcaaaaaa gcccagacga
    54061 aattgtctga gcattctttt atctagtcgt ttaaggaagt tgagttcagt atgtttaaag
    54121 tctctgtccc atcatttctt caacaaacct tgttcttgga gaaactcctt ggctacttgc
    54181 tttgctgact tgccttcaac accgacttgg tagttgagct ggctcatctg gctttctgta
    54241 atcttaccag ccaatgtatt aagaactctt tccaactctg ggtgtttctt gagaagagct
    54301 tctttcatga gtggagcccc ttgataaggt gggaagagtt gcttgtcatc ttccaagacc
    54361 tgtaaatcat aacgctccaa ttccgcatca gtcgaatagg catccgtgat ttgaatatcc
    54421 cctgactgaa ttgcctgata acgaagagct ggctgcatag tcgccacatt gagattgaga
    54481 ccatacattg attgcaagcc cttatttcca tcttcacggt cgttaaactc aagcgtaaag
    54541 cctgccttca gctgcccttc cacttttttc aaatccgaaa tggtcttcaa gccatattct
    54601 tgagcaatct ttttcggaac agctacagca taggtatttt gataagacat aggtttgaga
    54661 taggctagat gatcctgctt ggcaatgcca tcacgcgcca cttgataaac ctgctctggc
    54721 tcatgactca ccttgggtga tggttgaagc aaactttcag tcaccgtacc ggtaaattca
    54781 ggataaatgt caatatcacc ttttttcaga gcttcataaa ggaaacttgt cgtcccaaaa
    54841 ttcggtttaa cagtcgcagt catgctggta ttttcttcaa tcagcaattt atacatatta
    54901 gccaaaattt ctggttctgg gcctattttc ccagcaataa tcaagttttc cttctctttt
    54961 tgagccaaaa gggctggact ataagacaga cccagtaata aagccaccaa ggcaaaacca
    55021 gagaaaatcg tccgcaattt cgctttttcc attactttta gtaggaagtt aaaggcaata
    55081 gctagcactg cagaagaaag ggccccaatc aaaatcaaac tggcattatt acggtcaatt
    55141 cccaacagga taaaggaacc cagtccccct gccccaatca aggtcgccaa ggtagccgta
    55201 ccgataatca agaccgctgc cgtccgaatt ccagacatga taacaggcat ggcaagtgga
    55261 atttcaaact tcttgagacg ctcccatctg gtcatcccaa aggcaatccc agcctcttga
    55321 agactcggat caattccctt cagcccagta atagtatttt gtaaaatcgg aaaaatcgca
    55381 taaatcacta gagctgtcaa tgccggtaaa gtcccaattc ccatcaaggg aataaagagt
    55441 cccaacaagg ccagagacgg gatggtctgg aaaatccctg caatctgtaa gacccaatcc
    55501 gccaacttct catgatagcg aagataaaca gccaagggaa tcgcaagcaa aatagctagt
    55561 aacaaggtca aaagtgacaa ctgcaaatgt tgagataggg ctgtcaacca atcaccaaaa
    55621 cgatcctgaa aagttgcaat taaattagtc atgaacacta cctccaaaca agtctgcaac
    55681 aaagtctgtt gcaggagctt ttaaaatagt ctcaggattc gacacctgac gaatctctcc
    55741 atcctgcaaa acagcaatac gatctgccaa ctttaaggct tcatccgtat catgagtcac
    55801 aaaaatcgtt gtcatcccaa actctttatg taattctttt gtcagaacct gcaactgctt
    55861 gcgagaaata gcatccaagg ctgaaaaggg ttcatccatg aggagaatct tgggctgacc
    55921 aatcatagct cggacaatac cgacccgttg ctgttctcca ccagataatt cactaggtaa
    55981 gcgatgccca tactcggcta ctggtaaacc aaccttagcc aaaagctctt ctgttttctt
    56041 cgtaatttct tccttgctcc accccttcat ttcaggaatg agagcaatat tttccgcaac
    56101 tgttagattt ggaaaaagag caatagcctg taaaacatat ccagtagtaa gacgaagttc
    56161 acgctcatca tagtctttga tgcgcttgcc atccatataa atatttccat cagttggttc
    56221 caagagacgg ttaatcatct taatcatggt cgtcttacct gacccagaag gcccaactaa
    56281 aaccatgaac tccccattct caatctgtaa attgacatct ctcaagacat ctttttctgt
    56341 gtagcgcagt gctacatttt tgtattcaat cattctttgt cctcaattta aaacttccct
    56401 cgattagtca agtcttctac cttaggcatg acttccttat tatcccaatg ctccacaatt
    56461 ttcccgttct ctaaacggaa gatatcgtac tgggcataag caacgccatc aatctgagtc
    56521 tgaccatagc taaccacata gtttccttgt cctaagagtt ggaaaacaaa gtcaaaagtg
    56581 acactatatt cagccacata gtttttataa gcagcacttc cttgtccaat ctcatgatta
    56641 tgctgaatca aatcgtctgc cacataatca ctccactgct ctagctcccc attttggaaa
    56701 atttctgtca agaaacggcg aaccagcttt ttattttctg ctttcttatc caaatccttg
    56761 atttcaaaat ctccaaaaat ttgatctagt tggtcatttt caggtgttcg atagtagtca
    56821 atgacatccc aatgctcaac aatacaacca ttctcatccg cacggaaagt atccgtcgtc
    56881 acccattgag cttctccacc attcagatat tgatgaacat gaacaaagac cagattgcca
    56941 tcctcaatgg tgcggacaat cttaatctga cgctctggat gacgctcaaa gaaatctgca
    57001 aagaaggctg caaatccttc tttcccgtca ggaacacctg tcgaatgttg gatataggta
    57061 tcccctacag actgggcttg agcctcagca actcgtccgt cttgaatggc atggatgtat
    57121 aggttgtgag catttttcac ttgttgtgac atattctaaa cctcatttcc cttctctttc
    57181 agattcgcca aaattctttc ttgaaaacct tcaaattggt gaatttcttc ctctgaaaat
    57241 cctttgtaaa agatagtatc caatttctga ctgacacgat gccccacttc tttctgggac
    57301 ttgcctaact ccgttaaaac taaatacttc ttacgcttgt cttttccaca cggactaaca
    57361 attacaagct tttgttcctc tagctttttt atcatagtcg tcagcgtatt attcgcaagc
    57421 ccagtcgcaa gcgcgatatc tgtcgcagtt gcgcagccag tttcactatt ccataaaacc
    57481 gctaaaatct tgccctgttc acccctataa agagcctcag gatcttgact cagtaacttt
    57541 tgaaaaatcc gcccattcaa caaacgaata tgatgggcta gcaaatgact atctttcata
    57601 acacctccaa tttatgtcga tatcgaaatg aataaaataa ttgtaacact catcgttcta
    57661 actgtcaact atttcgattt ggaaataatt tttgataatt atccacacca ccatactccg
    57721 aatcaactaa cttttaacga gagtttctaa attccttcgt cctccagtct acaaaagcct
    57781 tccatccgta ctatcctata ttttatgagg ggacacattt ttcctatcag accatttatt
    57841 ttaaagatag aagtaaatca taattgcttc catctgttct tttatagtat attgaagttg
    57901 aactagggca ctgtatcttc taaaacattg ataaaaagcg atttgaattt cccaatcaat
    57961 ttgttcgtat ttatagcatt ttgaaattgg aataggacac catgactgct aaaagatttc
    58021 tataaattca tttgattttc ctaatcaatt tgttcatatc ttatttcatc ccgctataat
    58081 ttcaccttgc cctatctttt tcgtagcacc cttcaaacag cctatcccct accgtttgac
    58141 gattcctcac ttcgctccac ttccattaca gaagtttctt cactactatg gtctcggctg
    58201 acttctcatg attccttgtt actactattt gaacgctcac gagataggtc ttacaaaaaa
    58261 tgctttgatc cacaatggaa tcaaagcatt ttaaagagtt cctcatacat aagcgcagaa
    58321 gtcgcagttc ctctgtactt ggcttcttct cttttgataa agcgagccaa gttgagcaac
    58381 tcaggtgctg gatgtttggg atttaggagc aattcacgat tgaccaggcc tgagagacga
    58441 actgcctgca attgctcatt tgtagtaggc agttttttag cagtctctag gagagcagca
    58501 actaaatctt cactcaaatc atgtcgagca tgattgtaaa gatcttttat aaggctttct
    58561 aggtttggtt ctaccatccc taccacctcc cttatggttt aataatgttt aatcaaatca
    58621 accgttgaac gatccaattt cttcaccaag gcttgtaaga aagcttgcgc ttctaggaag
    58681 tcatccattg catagagggt ttggtgagaa tggatataac gagcgcagac accgatagtt
    58741 gttgatggga caccaccatt tttcagatga gctgcacctg catctgttcc gcctttacca
    58801 cagtagtatt ggtacttgat gccagcttct tcagccgttg tcaaaaggaa atccttcatc
    58861 tctgggagaa gcaagtgacc tggatcatag aaacgaatca aggttccatc tccaatcttg
    58921 ccttgaccac cgtagacatc acctgctggt gagcaatcaa ctgcgaggaa gacttctggg
    58981 tcaaacttgg ttgtagaggt atgagcgcca cgcagaccaa cttcttcttg gacgttagaa
    59041 cccagataga gttcattgcc gagtttttga cctgataaag cttcagctag ctcgcttacc
    59101 atgaggacac cgtagcggtt atcccaagct tttgagatga tatttttttc attggctgtc
    59161 aaaattgcag aactatctgg tacgatggta tcaccaggac ggatgccaaa actttctgcc
    59221 tcagccttgt ccgcaaaacc accatcaaaa acgatatcgg caatggctgg catggttggt
    59281 cccccctttc cacgagtcaa atgcggagga acagaacctg aaatcacagg aatttcatga
    59341 ccatcacgag tcaagagttt gaaacgttgg ctgctaacca ccatggggtt ccagccaccg
    59401 atttctacga cacggaaggt accatctggc ttgatttcgc tgaccataaa accaacttcg
    59461 tccatatgag aagcgaccaa gacgcgcggt gcatccacag cttctgaatg tttgatacca
    59521 aaaataccac ccaagccatc tgtcaccact tcatccacat gcggtgtcaa cttttcacga
    59581 agataagcac ggacaggcgc ttcatgacct gagactgcag caagttctgt tacttcttta
    59641 atttttgaaa ataatgttgt catttcagtt ccttctttct ttcatccatt ttaccacttt
    59701 ttataggaga aggatagtgg gaaggtggat ttctaagtta gtatcttagt cctgctctat
    59761 cttagaaaag gatagtattc tcttgcatgt agtgcaaaat ctagtaaaca ttccaaaatt
    59821 aactcgaata tttatttcca aacaaaaaaa caatacacca tcaaagttgt ttgtattttt
    59881 catgaaattt acagaaaata gttgacttcc ctttcttctt tctttaaata tatagttggt
    59941 tgagtttgga atagtacgct gtagctgcta aaacatttct agaaattaat ttgactttcc
    60001 taatagagtt gttcatatct tatttcaatt cactatagta caaaactaga aaaggaaaaa
    60061 atcatgacca aaacaattct tgttacaggt gggactagct acattggctc ccataccgtt
    60121 aaagctcttt taaatgctgg ttataaggtg catgtcctcg ataatctctc cacaggaaat
    60181 cgagcggctg tggatagtcg tgctagcttt aaagaactgg atgtttatga tgctagcgcc
    60241 ttaaaggctt acttagaaga aaatcagatt gatgctgtcc tccattatac aggtgaaatt
    60301 gttgtgagcg aaagtattga aaatccaagt aaatacttca ctgccaacgt tgctggtatg
    60361 aaccaagttc tcaaagtctt atctgaagtt ggcattcaaa aaatcatgtt ctcttcgact
    60421 gcttctctct atggaaataa ctgtattgac aagccggtga ctgaagatac cctgctcgac
    60481 cctgtcaacc cttatgcaga gacaaaactg atgggcgaac gaatgattta ctggatggcc
    60541 aatcgctacg actggaaata tgttattttc cgttacttta atgttgctgg ggctgaaatg
    60601 gatgcttcaa acggtctgcg tgtgaaaaat ccaactcaca tcattccaaa tatcaacaag
    60661 accgcattgg gacaaaatga tagcttaaaa atatttggag atgactacga tacacgtgac
    60721 ggttcatgta ttcgagatta catttatgtc ttggaccttg cataggctca tgttaaagga
    60781 atgaactacc tatttcaaga agacagttct tctcaaatct ttaacttagg aactaaaaaa
    60841 ggctatacta tcaaagaaat ctttaaaact gctgaagaat tactaaatta aaaaatccca
    60901 cacgagattg ttgctcgacg tgctagtgac ccagccagtg tcctagtaga tgcttcaaaa
    60961 gctaaacaat atcttgattg gacggctagc tactccctcg aagatattat tttatcagat
    61021 taaggtaaaa acattttaga ataggataac aaaggagaaa gtcttgttgc tctctccttg
    61081 ttgtatttat taaattgtca gaaattttat tgacagatta gaaaaataat gttacattta
    61141 tatccgcagg tatctttcga taccaaatct acataaaagg acggggtatg aaactttctc
    61201 attatttaat tggcttactt ctactcctag tctttctctc tattagcatt gggaccagtg
    61261 atttttcatg gggaaagcta tttgatttcg accagcagac ctggctcctc tttcaagagt
    61321 cccgtctccc aagaactatc agtattctcc tgactgcctc tagtatgagt atggcaggcc
    61381 ttctcatgca gactattacc caaaatcagt ttgctgcacc gagtacagtt ggaacgactg
    61441 aagccgccaa actggggatg gtgctgagcc tttttgtctt tccatcggct agtctgaccc
    61501 aaaagatgct cttcgctttt atttcatcca tcgtattcac cctcttcttc ctagccttta
    61561 tgaccatttt tactgtaaag gaaaggtgga tgttacctct gattgggatc atctatagcg
    61621 gaattatcgg ctcagtcaca gaagttatcg cctatcgttt caatctggtt cagagtatga
    61681 ctgcctggac ccagggctcc ttctccatga ttcagaccca tcagtatgag tggctcttct
    61741 taggcctcat catcctgata accgtttgga aattatccca aaccttcacc atcatgaatc
    61801 tagggaaaga aaccagcgag agtttgggga tttcctactc cctacttgaa aaactagccc
    61861 tctttctggt ggcgctaacg acaagcgtca ccatgattac cgtgggtggc ttaccatttc
    61921 tcggagttat cgttcccaat cttgttcgca agcgctatgg agataatcta agtcaaacca
    61981 aactcatggt cgcactggtt ggtgccaatc tagttctggc ttgcgatatc ctatcccgag
    62041 ttctgattag gccctatgag ttgtctgtca gtctcttgct aggaatcatc ggtagtctcg
    62101 tctttatcct acttctctgg agagggggac gaaaagatgc agactaaaag caaacatacc
    62161 aagctcttct ggattctcat tattcttgcc atcggagctt gtcttctcta cttttggccc
    62221 atcactcact tgtcagcctt tgcttggaag ttgcgttccc aaaagatcat cgtttatctc
    62281 ttggtagcca tcgcgactgg gatttcgacc attagttttc aaaccctgac ggaaaatcgc
    62341 ttcctgacgc ctagtatttt gggaattgaa tccttctacg tcctactaca aaccctacta
    62401 ctggtttttg aaagcaagtt tcttcaactt ggcaaatccc ctatcttaga attcctagtc
    62461 ttacttcttg tccagtccct cttctttctc gccttacaag gttacttgaa gacactgatg
    62521 aagcaagacc tggtcttcat cctgctgatc tgtctagcgc tcagaagtct ctttcgaaat
    62581 atcagtacct tccttcaagt cctaatggat ccaaacgaat acgataaact gcaaaatagt
    62641 ctttttgcct cctttcaaca tctcaacact tccatcctag ccatcggttc tctgatcatc
    62701 ctcgctttga caatcttttt ctttcgaaaa gcagtcgttc tagatgtctt gcacctgcaa
    62761 agagaaacgg ctcagatatt gggactcgat gttgaaaaag aacagaaaga gctcctctgg
    62821 ggaatcgtgc ttttgacctc aacggccact gccttggtag gacctatggc cttcttcggc
    62881 tttatgctgg ccaacctcac ctacctgatt gtcaaagact atcagcacaa gttactcttt
    62941 atagtggcca ttctggttgg atttattagc ttaaccttgg ggcaagcctt gattgaacga
    63001 gtctttgcac tggaaattcg tatcagtatg atcattgaga gtgtgggtgg cttcttattc
    63061 tttatcttac tatataggag gtctcgtcag tgaaactgga aaacattgac aaatccattc
    63121 aaaaacagga tattttgcaa ggcatttcgc ttgaagtcag tcctcaaaaa ctgacagcct
    63181 ttattggtcc aaatggtgct ggaaaatcga ctctcctctc catcatgagc agactaacca
    63241 agaaagatca gggagttctc agtatcaaag gacgtgaaat cgagagctgg aattcgcaag
    63301 aactggccca agaactaacc atcctaaaac agaaaatcaa ttaccaagcc aaattgactg
    63361 ttgaagaact ggtcagtttt ggacgttttc cctacagccg aggtcgactt agatcagaag
    63421 actgggaaaa aatccgagaa actctgaact atttggaact gaccaactta aaagaccgct
    63481 acatcaatag cctgtcaggg gggcaactcc agcgcgtctt tatcgctatg gtactggccc
    63541 aggatacgga ctttatcttg ctggacgaac cactcaacaa tctcgatatc aagcaaagcg
    63601 tcagcatgat gcaaattctt cgacgactgg tggaggaact cggcaagacc attatcatcg
    63661 tcctccacga tatcaacatg gccagtcagt atgcagatga aattgtcgcc ttcaaggacg
    63721 gtcaggtctt tagcaaggga agcaccgatc aaatcatgca ggctgacctg ctcagccaac
    63781 tttatgagat tcccatcacg ctagctgata tcaatgacaa aaagatctgt atctatagct
    63841 agtaacataa aagctcaagt tagagaacct tcagtctctt aatcaataag atcaagagac
    63901 tccctaaatc gttatcacat tttaaaaagg agaaattatg aaaacatccc ttaaacttta
    63961 tttcactgcc ctagtggcca gcttcttgct cctacttggt gcatgtagta caaactcaag
    64021 cactagtcag acagagacca gtagctctgc tccaacagag gtaaccatta aaagttcact
    64081 ggacgaggtc aaactttcca aagttcctga aaagattgtg acctttgacc tcggcgctgc
    64141 ggatactatt cgcgctttag gatttgaaaa aaatatcgtc ggaatgccta caaaaactgt
    64201 tccgacttat ctaaaagacc tagtgggaac tgtcaaaaat gttggttcta tgaaagaacc
    64261 tgatttagaa gctatcgccg cccttgagcc tgatttgatt atcgcttcac cacgtacaca
    64321 aaaattcgta gacaaattca aagaaatcgc cccaaccgtt ctcttccaag caagcaagga
    64381 cgactactgg acttctacca aggctaatat cgaatcctta gcaagtgcct tcggcgaaac
    64441 tggtacacag aaagccaagg aagaattggc caagctagac aagagcatcc aagaagtcgc
    64501 tactaaaaat gaaagctctg acaaaaaggc ccttgcgatc ctccttaatg aaggaaaaat
    64561 ggcagccttt ggtgccaaat ctcgtttctc tttcttgtac caaaccttga aattcaaacc
    64621 aactgataca acatttgaag actcacgcca cggacaagaa gtcagctttg aaagtgtcaa
    64681 agaaatcaac cctgacatcc tctttgtcat caaccgtacc cttgccatcg gtggggacaa
    64741 ctctagcaac gacggtgtcc tagaaaatgc ccttatcgct gaaacacctg ctgctaaaaa
    64801 tggtaagatt atccaactaa caccagacct ctggtatcta agcggaggcg gacttgaatc
    64861 aacaaaactc atgattgaag acatacaaaa agctttgaaa taagccactt caaactcaat
    64921 ttaatactca atgaaaatca aagagcaaac taggaaacta gccgcaggtt gctcaaaaca
    64981 ctgttttgag gttgcagatg aaagcagacg cggtttgaag ggattttcga agagtataaa
    65041 attttgacat tctaaaacgc atcctatcaa attcactcaa acctgatagg atgcgttttt
    65101 atcattttga aatctattta ccccacctca ttccccttct tgatttcgtt taagggaaaa
    65161 gtggtctgga acggggtcct tacctgtttt cgaccaggga tgacaacgta aaatccgagc
    65221 caagcccatc aataccccct taaaaccatg tttttcaata gcctgaatca tgtagttgga
    65281 acaagtcagc tcaaagcgac aagagggtgg aaagactggt gagataaaac gttggtaaaa
    65341 gcgcacaggc gctattaaaa ttcgtttcat tatttcttag ttacagccat ggtgtgtagt
    65401 tggctgattt cttttttatt aagacgacgg gattctcctg gacggagtcc tgtcaagtct
    65461 aggtgtccga aacgagtccg agacaactta tctacttgga gaccaacagc ttcaaacatc
    65521 tttttaacct gatggttacg cccttcatgg atggtcaact gcaccacaga gcgatttttg
    65581 actgggtcca ctttgagaat ttcataaaca gctggcttgg ttttcttacc atcaatctca
    65641 agaccacggg tcaaggggcg gagattgtcc ttattggcca cacctttaac acgcgcgaca
    65701 taaaccttgt caatctcatt acgagggtga atcatctcgt ctgtaaagtc cccatcattg
    65761 gtcaaaatca agacacctga tgtatcccag tccaaacgac ccacagggta aatacgttct
    65821 ttgacattgg gcaagaggtc gacaaccgtc ttgcgaccct tatcatctgt cacactggaa
    65881 atcacaccgc gtggtttgtt aagcagatag tagacctttt cttcgttgta gataggttga
    65941 ccttcaactt cgaccttgtc gcctgacttg atagtggttg ctagttcacg caccacttgg
    66001 ccgttaaccg tcaccaagcc ttgcttaatc agctcttctg cttttctcct actggccaca
    66061 cctgcgtggg caatatactt attgattctc atcttcttct atcctttcac caaataattg
    66121 gctttcttgg gcttgaatct caagctcatc aatcactggt aattcttcta aatggtttat
    66181 ccccatgtaa tctaggaaat aatccgtagt cacatagagg ttggggcgcc ccaatacttc
    66241 ctttttcccg tcttccttta tcaggtcaaa agcctgcaac tttgccaagg ctccactcga
    66301 gttaacccca cggatggcat caatttctat ccgcgtaatc ggctgtttgt aggcaataat
    66361 ggacaaggtc tcaagggcag cccgagacaa gctctggttg ataggcgcct tagagtattc
    66421 cttcaaaatt tctgcaaatt gaggcttggt caccaatcta taagcaccac ttgtctcaat
    66481 caaagccaaa ctggaatctg ggtccttttc atacttctgg gctaattttc ctaaactttg
    66541 ctggatacct gtcggtggca gagagaggag ttcagctaac tggcggaccc gaatcccatc
    66601 ttcacccgct acaaacaaga gcgcttctat ttttgctaaa gtactcatct ttcctctcta
    66661 tcaagtctag ctttgaggca cttgactttc ttccttcttt tccatgagat agatatctcc
    66721 gaaactctcc tcttgcacga ggatcagctc ctgggttttg attaactcta gggttgccaa
    66781 aaagagggtg atgatctctt ggacattctg ggcttccttg aacaaatcct gcaagcgcaa
    66841 ttgatctcgt ccaatcaagg attctttcac aataatcatc atgtcctcaa tcttatactc
    66901 atcccgcaag atagtcgtgt gattttgtgc aaactcctct tttttcttgg ctaggatatt
    66961 tgaaaaagcc aaaaagaggt caatggtcgt cttgtcatgc acaagctccg catcttcgta
    67021 aatcaactct gtcggcgctt tggaataata ctgggcccgt tcttggtgct tggcttccaa
    67081 gtgctcaccc aagagcttga acttgcgata ttcttcgatt tgagagagga ggtcctgctc
    67141 caggtcatcc cccaagtctg tcacttctgc taccttcgga aggagtttac gactcttaat
    67201 cagcatgagc tgactagcca tgaccatgta ctcacccgtc acttccagac gcatggcctg
    67261 cagggttgaa acataggcta gatactgttc gatgacttcc gtaatgggca catcgtagat
    67321 atccatctgg tacttagaaa ccagatgcaa gagcaagtcc aggggtcctt caaaatcttt
    67381 taatttaata tccattatct atatttttct aaggtcagga ctgtttttaa tcctaatttt
    67441 tttgcaattt cgtacaaatc gaccttgttt tctatttgtc ttagaataaa ctgttcacgt
    67501 aagacttgag ctgataagga tggaaaacct ttctccttga caaaagattc taactgacga
    67561 aaggcccact gacgagaata gggtttccct cctctttcaa aaagataggt ccgccccatc
    67621 aagggttcca attctgaaag caaggccatg ggaatggtga caatcctctg ttgggaagcc
    67681 ttgctgattc gcagcacctg aaaatccaga ttgatgtccg caaccttgat ggctaaaatc
    67741 tcactgggca agagccccat ttctaggatt aagagcgcta gcaagcggcc ctctggatgg
    67801 tcgctttcct gccaaaaaga gtctaggtat agaatctctg gcttttccgt cttcttttca
    67861 gcttgtttgg ctaattccaa gcggtaaaag ctgtccacct ctcctttttg atagagaaag
    67921 tagagaaatt ggttacaggc cgaaatcttt cgcttctggg cgctgatttt tagattggct
    67981 agctgggctt ggtaaatctt gagactggtc tcagaaatcc gctcacctac catgtctaaa
    68041 aattgctcca aatcatactt ataggactgc ttggaattga cagacaagcc ctgtttttcc
    68101 tctaaaaagg ctgaaatcct gtctctcatt ggcatcgaat ctcatattcc ttactaaagt
    68161 catgcaagag ggcattaacg gccttgagga tggacttgcg cgtaataatc ccttggaaaa
    68221 taccctctgc atccacaact ggtaagaagg actcatctac tagcttgtgc aagacctccg
    68281 taatggtgaa atcaggcgaa acaaccgcta cgtccgtttt tgtcatatga acgatatccg
    68341 tatccgccat gatttcttgg ctcaagtcat gctccatctg ataagccata atatctctga
    68401 gtccaatcgt cccaacaaac tgtttttcat ctgtcacaac gggaacacgg gtataggtca
    68461 tctgactaag caagagggtc gcatgatccg cattgtgggt atcaatcaac acagctagat
    68521 ttttagcagg ggtcaaaaaa gtttcctcct gccccaacaa gaaagtctca aactccttgg
    68581 caatcatcgg ctaaactcct tggacaaacc tggatacacc tcgtgatctc gtgtcaaaaa
    68641 gtccactttg aagtaactat catcaatctc cacacgagca tagagacatt ctctgatggt
    68701 acctcgtggt tggctgatag aacctggatt tagaaagagg atcttgcctt ccatccaagc
    68761 acttggcaca tgcaagtgac catagaggca gatagcggcc tcttcctcct gagcccagta
    68821 gtccaacttt tgaaagttga aattgatgtc aaacaagtga ccatgagttt ggataatctt
    68881 ggtcgaacca agctcagtca ccagacgttc tgggtagccg gcgtagaagt ccatgttccc
    68941 tttaacaacg cggatgccct cccaaagtgg aaaatccgga cgtagttcag aatcgccgtt
    69001 atgaaaaacg gcatcgactt tgcccacata gcgatcacgg acttcttcca caatcaagct
    69061 atcgccatgg gaatcgctca ttacaatgat ggtttgcttt gccatgatgg aaatacctcc
    69121 aaaagtttct taacggctaa ggcacggtga gattgactat ttttttcttc cagggttaat
    69181 tcagctgatg actcacctgt ctctcctaca aggaagaggg gatcatagcc aaagccattt
    69241 tcacccttag gttcaaagtt aatataacct gaccagtctg cttcaacaac taaactttcc
    69301 ttatttgggc tggctacgac tagggttgtg tggaactgag ccgagcggtc cttgagttca
    69361 aagaccatgg ccaattcgtg caagagtttg gaattatttt cacggtcagt tgctcccaca
    69421 cctgcgaaac gagctgacca gacgcctggt aagccaccaa ggacatcgac tttgagacca
    69481 gaatcatctg ccaaaaccat cttgcccgtt aattgagaaa tggtttctgc cttaaggcgg
    69541 gcattttctt caaaggtcat acctgtttct gctacttcag gcaggtcagg gtagtcatta
    69601 agattttcca catcgtagcc taacttatca aagatagctc ggaattcctt ggttttacct
    69661 tcgttacgag tcgcaatcaa caaggtttct ctgaccttgc ttgtctcaaa gaaatcatga
    69721 acattgaccc cttctttagg caattctaca tacaagagtt gcccattttc aaccaagagc
    69781 agggccccat gacgttgaat aacttccaag tttcgtccca tttcttgatt aagcatgtct
    69841 accacaaagg agaacaaacg gtaggtagaa ccatagcgta aaacagtaac tgaaagcggg
    69901 aaaccatact cttcatctcc aaatattttg gagaattcaa acagaggaaa atctgtctta
    69961 tagtcgctca aactgttaac gccaccaaaa atactataag acccaacata ccagtcctgg
    70021 tcatccttat attcataaat tttatttgtc ataattctac atgctccaca tgaatctctt
    70081 tttccagcca ttcttcacca atttgtgcaa aactttggct actggctgtt gtgtaaaaac
    70141 ggtgatggag tggtccagca tcgcgaccac gattgatttc aaaataattg agtaagactg
    70201 agatatcccg tacgcactct gccccactat cgatgagctg aacctttggc cccatcacat
    70261 tttggataat agggcgaagg agtggataat gagtacagcc caaaatcagg ctatccacct
    70321 ttccaaccaa gggacgcagg gtttcataga ccaccttctt ggtaacactg gttgacaggg
    70381 cacctgactc aaccaaggga gcaaacttgg gacaggccaa gctctccacc tgtaagtcgg
    70441 gatccagatc atggattttc ttacggtata tgtctgattg taccgtcatg ggcgttccaa
    70501 tcactccgat tttcccacct tgactggact tgatggctgc cgaagctcct ggcaaaatta
    70561 cacccaagac aggaatatct agttgagcct tgatttcttc ccagacgacc gcagtcgcag
    70621 tgttacaagc aatgacaatc attttgacat ccttagtcaa gagaaagttg accagctgcc
    70681 aagtatattc acgaatttgc tcagcaggac gggggccata gggcgcccgc gccgaatctc
    70741 caatatagac gatttcttca tggggaagct ggcgcatgag ctcgcgcaca acggtcaagc
    70801 ccccgacacc cgaatccaaa aaaccaattg gtcgattatc catacagtct tctttctagt
    70861 cttttttctg attgatcgtt cattatgatt ccttgtactg aacgaactga ccgacagctt
    70921 gatagaatgt caactacctc tctcttaatc ataatcaaat atcaatagaa tgcaaggaaa
    70981 aagtctcatc cctaaaccat aaccaacata gtgagaagtc tggaactttc atcccagact
    71041 tttccttatt tattttttct ttttattgtt agcaagggct gccttttgtt ggcggatgat
    71101 ttggtggtaa acttgttgta ccttagcttc gcttggtttt tgaccatttg cactcaaaag
    71161 agtacgaact gcttcagcat tcaaacgtgg gttgtcagca aattcttttt cgatttgctt
    71221 acgaaccaag tacattcctc caagagctcc tcctagaaaa gctagcacaa tcaatacaat
    71281 tgctaaaagt aaatccatca tttttctcct gtttcttttt gagtcccttt cattatacca
    71341 caaactagcc accctgacca gtttgttcta cactttcagg gatggaatag acagcaaaaa
    71401 gaaccctgct tttctgaaaa agaggtctcc ttgctaagtt tatactcaat gaaaatcaaa
    71461 gagcaaacta ggaagctagc cacaggttgc tcaaagcacc gctttgaggt tgcagataaa
    71521 actgacacgg tttgaagaga ttttcgaaga gtattaattt acataaatag ccagtgtttg
    71581 atagggtttg agtagaattt tctcagacac ttctgcatct tcatagtttg atatcaaaat
    71641 ctgtccattt tggtagactg ctggcaagtc gatttccact tctttagcat aaaagttatt
    71701 gagcactagt aacttttgat cctcaaactg gcgttcaaaa gcgtagactt gtttgctatc
    71761 ttcaaaggct ggtttgtaac ttccttctga aatgattggc atttccttac gcagtcgaat
    71821 caagtcttga tagaaggtaa aaatcggacc ctggatttca ttttctacat tgatgtattt
    71881 ataggattta ccagctttca accaaggagt gcctgttgaa aatcctgcat tttccgaagc
    71941 atcccactgc atgggaatgc gtgaattatc acgcgactta gcttgaataa tctggaaggc
    72001 ttcttgctga ctctttcctt cttctaagag catctgatag gcattaagcg attcgacatc
    72061 cacataatca gccatagaat catagtctgg gtcaatcatc ccgatttcct cacccatgta
    72121 gatataaggt gtcccacgtg acaggtgaat gctggctgct agcatggtgg ctccttcctt
    72181 gcggaagttt tgaatatcga caaaacggtt caaggcacgt ggttgatcgt gattgttcca
    72241 aaagagggca ctccaaccgt ctttatcact catttcctta ccccaactat ggtaaagact
    72301 cttcaactct tcaaaatcaa agggagccaa ggtccacttt tgtccatcct tatagtccac
    72361 cttgaggtga tgaaaattaa aggtcatgga taattcctga cgatcaggcg acgaatagag
    72421 gacacagttt tccatggtgg tagaagacat ttccccaact gtcataaagc tatcgtcaga
    72481 tccaaaagtg gcttggttca tcatacgcaa atagttatga acgatgggtt tgtctgtata
    72541 agctggcttc ccttcatttt caggacagtc cactgaaacc tcgtccttac cgatcaaatt
    72601 gatcacatca aatcggaaac ctttgacacc cttgtcgcgc cagaaattaa caaccttgaa
    72661 aagctcctta cggacattgg aattgcgcca gttaaggtca gcctgggtct catcaaatag
    72721 gtgaagatag tatttcccag tatccccgaa aggcgcccat gcagaaccac caaacttaga
    72781 ctgccaatct gttggttggt cttggatgaa gaaaaagtct tgataatact tatcaccagc
    72841 tagggctttc tgaaaccatt catgctctgt cgaacaatga ttaagtacca tgtccagcat
    72901 aaagtcaatc ttgtgctctt taccgacaca caccatttcc tcaaaatcag ccatatcacc
    72961 aaaaagagga tccactgcca tataatctga aatatcgtaa ccattatccc gttgagggct
    73021 tggatagaat ggattgagcc agaccatatc cacacctagt ttggctaaat agggaatttt
    73081 ttcgataatc ccacggaaat ccccaatacc gttttcagtg gtgtctttgt aagattttgg
    73141 atagatttga tagactactt ttcctttatc aagtgtcatc tgtttctcct tttctgataa
    73201 aagggaggaa gcagtcttcc gtccctattt gtgctatttc aattatactc aatgaaaatc
    73261 aaagaacaaa ctaggaagct agccacaggt tgctcaaaac actattttga ggttgcagat
    73321 agagctgacg tggtttgaag agattttcga agagtattag attcgtgtag cgaccatgag
    73381 agatgctcca gcttggatcg ttgtcggata agttccggga atagtcgctg tataagcatc
    73441 ttggttggtg atgataacag gagtttctgt caccagacct gcagccttaa tgacatccat
    73501 atcaaaacga atcagttgct gaccaactgt aacgtgatct ccttggacta caagactttc
    73561 aaaacctttg ccatcaagac ctactgtatc cataccgatg tggatgagca attcaactcc
    73621 ctcgtcagag acaatgccga tggcatgctt ggtagggaaa agaaccgtca ctgtcccatt
    73681 aactggagag gtcaactcac cttggcttgg ttcaatgacc agaccttgcc ccatgacacc
    73741 tgatgcaaaa acaggatccg tcgcttgact caattctttc acttggccag ttagtgggct
    73801 gataatttct accgaagtaa gttctactag ttcatggctc acaaattctg cttcttcttg
    73861 agcaacgaat tctgcctgca agttcgtatc gccctctgtt tttgtaaaga gaccagcctt
    73921 gcggaagaag aaagtcaaga gcattggaac aacaatcgca actagcatag ttcctgcaaa
    73981 tggcagcatg tattgaggtt gaatagagag aatacctggc aaaccaccga taccaataga
    74041 agccgcagtt acattaaaag taacggataa catgcctgca agggctgaac cagtcatccc
    74101 agcaacaaat ggataaatat attttacgtt aaccccaaaa agagctggtt ctgtaacacc
    74161 gagataggct gaaatggttg caggaagtga aacctgagcc tcacgctcat catggcgatg
    74221 catgaaataa taggcaaaca cggctgagcc ttgagcaata ttagaaagag caatcattgg
    74281 ccagagggca gtgccaccag catccgcaat caattgtgta tcaatggcat tggtcatatg
    74341 gtgcagacct gtgatgacaa atggagcgta gagggcacca aaaattgcac cgaagagcca
    74401 tttaactgga cccgttaaac ctgccaagac aactgatgaa agtccttgtc caattgtcca
    74461 accgattggt cccaaaacag tgtgagccaa aatcaaggct ggaatcaatg acaaaaaagg
    74521 tacaaaaatc atggaaatga cttctgggat atgtttgcgc cagaaaattt caagataaga
    74581 cagactcaaa cctgcaagta aggctgggat aacttgggct tggtaaccaa tacgattaac
    74641 agtaaaataa ccaaaattcc aaacccagtt tgctgcgata tcagctgctg gcgttgaagc
    74701 aaccgcatag gcattgagca actgaggcga taccaaacag attccgagaa caattcccaa
    74761 aatttggctg gttcccatct tacgagaaac agaccaagta atccctactg gtaagaactg
    74821 gaagatagct tcaccaggca accagaggaa gtgattaacc cctgcccaaa actgagagga
    74881 ttctgtgatg gtcttgccat ccaacatcga ccaatggaca ccttccaaga cattacggaa
    74941 accgaggatc aatccaccaa caatcaaggc tggaataatc ggagtaaaga tttccgccag
    75001 agtggtcata acaccttgga ccacgttttg attactctta gctgcagact tggctgcttc
    75061 tttggaaaca ccctcaatac ctgaaacggc tgtaaaatca ttataaaaga tgggcacgtc
    75121 atttccaatg attacctgaa attgacctgc atttgtaaag gttcctttaa cagctggaat
    75181 tgactcgata gctttaacat tagccttctt atcatctctt aaaacaaagc acatccgtgt
    75241 cgcacagtga gttacggcag tcacattttc tttgcctcca attgcctgaa gcagatcttt
    75301 ggcttcttgt tcaaattttc ccatttgatt ctccttatac ttgtcaaagc aagtttgatt
    75361 tgataagtat attgtaaacg ataccaaact tgtctgcaac ttgtttggta taaaaagggt
    75421 gtttttttgt aaattttcta gcacttgtat ggtaaaatag atacaggtgt tcattaaact
    75481 agactaaaaa cctatttaag caggcaaaat gaagaaatac caacaattat ttaagcaaat
    75541 ccaagaaacc attcaaaacg agacttacgc tgtcggagat ttccttccta gcgagcacga
    75601 ccttatggag caatatcaag tgagtcgtga taccgtccga aaggccctgt ctctcctcca
    75661 agaggaagga ttgatcaaaa agataagagg gcaaggttct caagtcgtca aagaagaaac
    75721 cgtcaatttc cctgtatcca acctaaccag ctaccaagaa ctagttaaag aacttggact
    75781 gcgctctaaa accaacgtgg tcagtctgga caagattatt attgataaaa aatcctcact
    75841 gataaccggt ttcccagagt ttcggatggt ttggaaggtg gtccgccagc gtgtggtgga
    75901 tgatctggta tccgttctgg atacggacta tctggatatg gaactaatcc caaatctcac
    75961 tcgccaaatt gctgagcagt ctatctattc ttatatagaa aatggcctca aactccttat
    76021 tgattatgct cagaaggaaa tcaccattga ccactcaagc gaccgagaca agattctcat
    76081 ggacattggc aaagaccctt atgtcgtttc gattaaatca aaagtctatc tccaagacgg
    76141 acgccaattt cagtttaccg aaagtcgcca taagttagaa aaatttagat ttgtagattt
    76201 tgcaaaacgc aagaaataaa agactgagac accagatctc agcctttttc ggctctataa
    76261 tatttgtagt gggtaaatcc actatagata ttatggagcc tatttt
//
LOCUS       DBERMM010000006        73464 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.006, whole genome shotgun sequence.
ACCESSION   DBERMM010000006 DBERMM010000000
VERSION     DBERMM010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 73464)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 73464)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..73464
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.006"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(60..308)
                     /locus_tag="ACL8AS_000520"
     CDS             complement(60..308)
                     /locus_tag="ACL8AS_000520"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000155489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228435.1"
                     /translation="MASTSLQAPAKICFILIKLYSPYAFLSKYLGAILLSFFCYYAKE
                     IGCNNLTLSVWNDNEGALRFYQRQGMKPQETTMEMIID"
     gene            complement(256..1338)
                     /locus_tag="ACL8AS_000521"
     CDS             complement(256..1338)
                     /locus_tag="ACL8AS_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M24 family metallopeptidase"
                     /protein_id="HGS1228436.1"
                     /translation="MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFL
                     FVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFD
                     NLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
                     ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFD
                     LGVLVNGYASDMTRTVAVGKPDQFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAARE
                     VIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVR
                     IEDCGVVTKDGFDLFTSTSKDLLYFD"
     gene            complement(1464..2246)
                     /gene="gatD"
                     /locus_tag="ACL8AS_000522"
     CDS             complement(1464..2246)
                     /gene="gatD"
                     /locus_tag="ACL8AS_000522"
                     /EC_number="6.3.5.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004359 - glutaminase activity [Evidence
                     IEA];
                     GO_function: GO:0140282 - carbon-nitrogen ligase activity
                     on lipid II [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipid II isoglutaminyl synthase subunit GatD"
                     /protein_id="HGS1228437.1"
                     /translation="MVYTSLSSKDGNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAE
                     KLGAHVTVDIVSLHDDFDENHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGV
                     VLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYG
                     FENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAY
                     RLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS"
     gene            complement(2246..3589)
                     /gene="murT"
                     /locus_tag="ACL8AS_000523"
     CDS             complement(2246..3589)
                     /gene="murT"
                     /locus_tag="ACL8AS_000523"
                     /EC_number="6.3.5.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016881 - acid-amino acid ligase activity
                     [Evidence IEA];
                     GO_function: GO:0140282 - carbon-nitrogen ligase activity
                     on lipid II [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipid II isoglutaminyl synthase subunit MurT"
                     /protein_id="HGS1228438.1"
                     /translation="MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNL
                     AKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKT
                     GKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILEAIRKVPT
                     ATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNT
                     YANLGAYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALA
                     AVAIARFLGADSQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIK
                     LAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVT
                     GYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN"
     gene            complement(3688..5004)
                     /locus_tag="ACL8AS_000524"
     CDS             complement(3688..5004)
                     /locus_tag="ACL8AS_000524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000958936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016668 - oxidoreductase activity, acting
                     on a sulfur group of donors, NAD(P) as acceptor [Evidence
                     IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-containing oxidoreductase"
                     /protein_id="HGS1228439.1"
                     /translation="MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCI
                     NIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNGKNYATVAGTGVDIFDAEAHFLS
                     NKVIEIQAGDEKKELTAETIVINTGAVSNVLPIPGLATSKNIFDSTGIQSLDKLPEKL
                     GILGGGNIGLEFAGLYNKLGSKVTVLDALDTFLPRAEPSIAALAKQYMEEDGIELLQN
                     IHTTEIKNDGDQVLVVTEDETYRFDALLYATGRKPNVEPLQLENTDIELTERGAIKVD
                     KHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFIT
                     PALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGAS
                     IFSEGSQEIINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI"
     gene            5197..6423
                     /locus_tag="ACL8AS_000525"
     CDS             5197..6423
                     /locus_tag="ACL8AS_000525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="OFA family MFS transporter"
                     /protein_id="HGS1228440.1"
                     /translation="MKSNRYIIAFAGVILHLMLGSTYAWSVYRNPIIEKTGWDQASVA
                     FAFSLAIFCLGLSAAFMGRLVEKFGPRVMGSLSAFLYAGGNILTGFAIDRQELWLLYL
                     AYGILGGLGLGAGYITPVSTIIKWFPDKRGLATGLAIMGFGFASLLTSPIAQHLIAGV
                     GLVETFYILGASYFIIMLLASQFIKRPNEQELAILSASGKEKTDSLTQGMTANQALKS
                     NRFYILWIIFFINIACGLGLISAASPMAQEMAGLSTSHAAVMVGVLGIFNGFGRLLWA
                     SLSDYIGRPLTFSILLLVNLLFSLSLWLFTDSVLFVVAMSILMTCYGAGFSLIPAYLS
                     DIFGTKELAALHGYILTAWAMAGLAGPILLAETYKMAHSYTQTLFVFLILYSIALALS
                     YYLGRSIKKESQKPLT"
     gene            6622..8196
                     /locus_tag="ACL8AS_000526"
     CDS             6622..8196
                     /locus_tag="ACL8AS_000526"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HGS1228441.1"
                     /translation="MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQ
                     AQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRS
                     VYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQNIETLILDEADEMLNMGF
                     LEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYY
                     IRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQN
                     KRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAG
                     KSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADE
                     TIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGN
                     GFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNT
                     LSEKQTGFVIRNKGDK"
     gene            8460..9248
                     /gene="codY"
                     /locus_tag="ACL8AS_000527"
     CDS             8460..9248
                     /gene="codY"
                     /locus_tag="ACL8AS_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HGS1228442.1"
                     /translation="MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNAC
                     IINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIF
                     PVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN
                     FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITR
                     SVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY"
     gene            9248..9823
                     /locus_tag="ACL8AS_000528"
     CDS             9248..9823
                     /locus_tag="ACL8AS_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase family protein"
                     /protein_id="HGS1228443.1"
                     /translation="MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFER
                     GDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMD
                     KRHYSAFSGTDLDIRLRERRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS
                     IWPENHQFALGHFKNTLGAKLVDENLNELSE"
     gene            9905..9990
                     /locus_tag="ACL8AS_000529"
     tRNA            9905..9990
                     /locus_tag="ACL8AS_000529"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:9939..9941,aa:Leu,seq:aag)
     gene            10273..11403
                     /locus_tag="ACL8AS_000530"
     CDS             10273..11403
                     /locus_tag="ACL8AS_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228444.1"
                     /translation="MVELNLKNIYKKYPNSEHYSVEDFNLNIKDKEFIVFVGPSGCGK
                     STTLRMIAGLEDITEGTASIDGVVVNDVAPKDRDIAMVFQNYALYPHMTVYDNMAFGL
                     KLRKYSKEDINKRVQEAAEILGLKEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD
                     EPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATKNPAGT
                     GTIGRVEQIGTPQEVYKNPVNKFVAGFIGSPAMNFINVKLVGSEIVSDGFRLKVPEGA
                     LKVLREKGYEGKELIFGIRPEDVNAEPAFLETFPDCVVKATISVSELLGSESHLYCQV
                     GKDEFVAKVDARDYLQTGATVELGFDLNKAHFFDVETEKTIY"
     gene            11904..12662
                     /locus_tag="ACL8AS_000531"
     CDS             11904..12662
                     /locus_tag="ACL8AS_000531"
                     /EC_number="2.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001848902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HGS1228445.1"
                     /translation="MSEAGHKFLAKLGKKRLRPGGKRATDWLIAEGGFSKEKRILEVA
                     CNRGTTAIELAQRFGCKITAVDMDAQALEVAKKSAGTAGVAHLISFERANAMKLPYQD
                     ASFDIVINEAMLTMQADQAKKKCVMEYLRVLKPGGLLLTHDVLLKEAKESIRQELSQA
                     IHVNVGPLTQDGWEQVMIESGYCDVKVLTGEMTLMKLSGMIYDEGLLGTLKICVNACK
                     KENRKQFLTMYKMFAKNKQKLGFIAMASYKSSKR"
     gene            12749..13261
                     /locus_tag="ACL8AS_000532"
     CDS             12749..13261
                     /locus_tag="ACL8AS_000532"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0006168 - adenine salvage [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HGS1228446.1"
                     /translation="MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYA
                     TDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLT
                     MHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
                     DYDYKVLMHY"
     gene            13443..14387
                     /gene="metA"
                     /locus_tag="ACL8AS_000533"
     CDS             13443..14387
                     /gene="metA"
                     /locus_tag="ACL8AS_000533"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008899 - homoserine O-succinyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0019281 - L-methionine biosynthetic process
                     from homoserine via O-succinyl-L-homoserine and
                     cystathionine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HGS1228447.1"
                     /translation="MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLM
                     PQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFLEVKDEYFDG
                     MIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
                     DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVG
                     VSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLC
                     WSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL"
     gene            14396..15073
                     /locus_tag="ACL8AS_000534"
     CDS             14396..15073
                     /locus_tag="ACL8AS_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006269 - DNA replication, synthesis of
                     primer [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HGS1228448.1"
                     /translation="MTYLDAFKSGTLVLPSALLLHFKELFPSSDDFLVWQFFYLQNTT
                     GLEEMSPSQIAERIGKEISDVNQSISNLTERGLLQYRTIELNGEIELLFDASLALERL
                     DDLFGAVHSSSDQLTPQNQLKDLVETFQQELGRLLTPFEIEDLTKTLKEDGTSADLIK
                     EALREAVLNGKPNWKYIQAILRNWRHEGIKSVAQIEAKRAEREASNPQLIQVSADFRN
                     AMDLWKD"
     gene            15171..15929
                     /gene="tpiA"
                     /locus_tag="ACL8AS_000535"
     CDS             15171..15929
                     /gene="tpiA"
                     /locus_tag="ACL8AS_000535"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000087908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004807 - triose-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HGS1228449.1"
                     /translation="MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAP
                     ALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDY
                     FHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQV
                     AASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPE
                     NVASYMACPDVDGALVGGASLEAESFLALLDFVK"
     gene            15967..17472
                     /gene="lytC"
                     /locus_tag="ACL8AS_000536"
     CDS             15967..17472
                     /gene="lytC"
                     /locus_tag="ACL8AS_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078138769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase LytC"
                     /protein_id="HGS1228450.1"
                     /translation="MSVTFFIGEQRLKTKIGLASICLLGLATSHVAANETEVAKTSQD
                     TTTASSSSEQNQSSNKTQTSAEVQTNAAAHWDGDYYVKDDGSKAQSEWIFDNYYKAWF
                     YINSDGRYSQNEWHGNYYLKSGGYMAQNEWIYDSNYKSWFYLKSDGAYAHQEWQLIGN
                     KWYYFKKWGYMAKSQWQGSYFLNGQGAMMQNEWLYDPAYSAYFYLKSDGTYANQEWQK
                     VGGKWYYFKKWGYMARNEWQGNYYLTGSGAMATDEVIMDGTRYIFAASGELKEKKDLN
                     VGWVHRDGKRYFFNNREEQVGTEHAKKVIDISEHNGRINDWKKVIDENEVDGVIVRLG
                     YSGKEDKELAHNIKELNRLGIPYGVYLYTYAENETDAESDAKQTIELIKKYNMNLSYP
                     IYYDVENWEYVNKSKRAPSDTGTWVKIINKYMDTMKQAGYQNVYVYSYRSLLQTRLKH
                     PDILKHVNWVAAYTNALEWENPHYSGKKGWQYTSSEYMKGIQGRVDVSVWY"
     gene            17968..18486
                     /locus_tag="ACL8AS_000537"
     CDS             17968..18486
                     /locus_tag="ACL8AS_000537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="HGS1228451.1"
                     /translation="MVELKKEAVKDVTSLTKAAPVALAKTKEVLNQAVADLYVAHVAL
                     HQVHWYMHGRGFLVWHPKMDEYMEALDGQLDEISERLITLGGSPFSTLTEFLQNSEIE
                     EEAGEYRNVEESLERVLVIYRYLSELFQKGLDVTDEEGDDVTNGIFAGAKTETDKTIW
                     MLAAELGQAPGL"
     gene            18616..19122
                     /locus_tag="ACL8AS_000538"
     CDS             18616..19122
                     /locus_tag="ACL8AS_000538"
                     /EC_number="1.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004146 - dihydrofolate reductase activity
                     [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="HGS1228452.1"
                     /translation="MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAIL
                     MGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGG
                     KQIFQAFEAYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTI
                     QYRKRKEV"
     gene            19122..19292
                     /locus_tag="ACL8AS_000539"
     CDS             19122..19292
                     /locus_tag="ACL8AS_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000442275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228453.1"
                     /translation="MERSLFGLFTAFLCFICFLAGAQAFRKKRYGLSILLWLNAFTNL
                     VNSIHAFYMTLF"
     gene            19324..20556
                     /gene="clpX"
                     /locus_tag="ACL8AS_000540"
     CDS             19324..20556
                     /gene="clpX"
                     /locus_tag="ACL8AS_000540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002874765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HGS1228454.1"
                     /translation="MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQE
                     IIREELVEEVLADLSEVPKPIELLHILNHYVIGQDRAKRALAVAVYNHYKRINFHDTR
                     EESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
                     ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGT
                     VASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRMGEKVIGFGQNNKAI
                     DENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALVKQYQ
                     TLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLV
                     RITKETVDGTDKPILETA"
     gene            20565..21152
                     /gene="yihA"
                     /locus_tag="ACL8AS_000541"
     CDS             20565..21152
                     /gene="yihA"
                     /locus_tag="ACL8AS_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002915299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTP-binding protein
                     YihA/YsxC"
                     /protein_id="HGS1228455.1"
                     /translation="MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINT
                     MLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGCMIEEYL
                     TTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESA
                     IKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL"
     gene            21163..21543
                     /locus_tag="ACL8AS_000542"
     CDS             21163..21543
                     /locus_tag="ACL8AS_000542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HGS1228456.1"
                     /translation="MAKTIHTDKAPKAIGPYVQGKIVGNLLFASGQVPLSPETGEIVG
                     ENIQEQTEQVLKNIGAILAEAGTDFDHVVKTTCFLSDMNDFVPFNEVYQTAFKEEFPA
                     RSAVEVARLPRDVKVEIEVIAEIG"
     gene            21595..22485
                     /gene="rapZ"
                     /locus_tag="ACL8AS_000543"
     CDS             21595..22485
                     /gene="rapZ"
                     /locus_tag="ACL8AS_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HGS1228457.1"
                     /translation="MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPK
                     FLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVA
                     RYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFS
                     DQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVM
                     NHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKRLVQDLSKN
                     WSVNEGHRDKDRRKETVNRS"
     gene            22482..23459
                     /locus_tag="ACL8AS_000544"
     CDS             22482..23459
                     /locus_tag="ACL8AS_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HGS1228458.1"
                     /translation="MRKPKITVIGGGTGIPVILKSLREKDVEIAAIVTVADDGGSSGE
                     LRKNMQQLTPPGDLRNVLVAMSDMPKFYEKVFQYRFSEDAGAFAGHPLGNLIIAGLSE
                     MQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVAGESHIVDHRGIIDNV
                     YVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEI
                     AYVCNIMTQRGETEHFTDSDHVEVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYL
                     VQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMRIIQVKK"
     gene            23456..24367
                     /gene="whiA"
                     /locus_tag="ACL8AS_000545"
     CDS             23456..24367
                     /gene="whiA"
                     /locus_tag="ACL8AS_000545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0043937 - regulation of sporulation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HGS1228459.1"
                     /translation="MSFTVAVKEEILGQHHLSWHELSAIIKMSGSIGLSTSGLTLSVV
                     TENAKLARHLYESFLHFYEIKSEIRHHQRSNLRKNRVYTVFTDEKVQDLLSDLHLADS
                     FFGLETGIDEAILSDEEAGRAYLCGAFLANGSIRDPESGKYQLEISSVYLDHAQGIAS
                     LLQQFLLDAKVLERKKGAVTYLQRAEDIMDFLIVIGAMQARDDFERVKILRETRNDLN
                     RANNAETANIARTVSASMKTINNISKIKDIMGLENLPVDLQEVAQLRIQHPDYSIQQL
                     ADSLSTPLTKSGVNHRLRKINKIADEL"
     gene            complement(24401..25369)
                     /locus_tag="ACL8AS_000546"
     CDS             complement(24401..25369)
                     /locus_tag="ACL8AS_000546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000081018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HGS1228460.1"
                     /translation="MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPA
                     ILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTS
                     KGSHLTKTVIIAMGGGAFKPRPLELESVEGYENIHYHVSNIQQYAGKKVTILGGGDSA
                     VDWALAFEKIAPTTLVHRRDNFRALEHSVQALQESSVTIKTPFAPSQLLGNGKTLDKL
                     EITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLDLNRHKIIVNSKQESSQAGIYA
                     IGDCCYYDGKIDLIATGLGEAPTAVNNAINYIDPEQKVQPKHSTSL"
     gene            25505..26362
                     /gene="cdaA"
                     /locus_tag="ACL8AS_000547"
     CDS             25505..26362
                     /gene="cdaA"
                     /locus_tag="ACL8AS_000547"
                     /EC_number="2.7.7.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001867651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004016 - adenylate cyclase activity
                     [Evidence IEA];
                     GO_process: GO:0006171 - cAMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diadenylate cyclase CdaA"
                     /protein_id="HGS1228461.1"
                     /translation="MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIA
                     GTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLER
                     LGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYISTGIPLD
                     AKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIG
                     LSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERL
                     LGGWKHEKK"
     gene            26349..27128
                     /locus_tag="ACL8AS_000548"
     CDS             26349..27128
                     /locus_tag="ACL8AS_000548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CdaR family protein"
                     /protein_id="HGS1228462.1"
                     /translation="MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNT
                     VTNVPIDIRYNSDKYFISGFASEVSVVLTGANRLSLASEMQESTRKFKVTADLTDAGV
                     GTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSRVQIENV
                     MVSDKEVSITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITP
                     FDTIMKVTTKPVAPSSSTSNSSTSSSSETSSSTKATSSKTN"
     gene            27152..28504
                     /gene="glmM"
                     /locus_tag="ACL8AS_000549"
     CDS             27152..28504
                     /gene="glmM"
                     /locus_tag="ACL8AS_000549"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0008966 - phosphoglucosamine mutase
                     activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HGS1228463.1"
                     /translation="MGKYFGTDGVRGEANLELTPELAFKLGRFGGYVLSQHETEAPKV
                     FVGRDTRISGEMLESALVAGLLSVGIHVYKLGVLATPAVAYLVETEGASAGVMISASH
                     NPALDNGIKFFGGDGFKLDDEKEAEIEALLDAEEDTLPRPSAEGLGILVDYPEGLRKY
                     EGYLVSTGTPLDGMKVALDTANGAASTSARQIFADLGAQLTVIGETPDGLNINLNVGS
                     THPEALQEVVKESGSAIGLAFDGDSDRLIAVDENGDIVDGDKIMYIIGKYLSEKGQLA
                     QNTIVTTVMSNLGFHKALNREGINKAVTAVGDRYVVEEMRKSGYNLGGEQSGHVILMD
                     YNTTGDGQLSAVQLTKIMKETGKSLSELAAEVTIYPQKLVNIRVENVMKEKAMEVPAI
                     KAIIEKMEEEMAGNGRILVRPSGTEPLLRVMAEAPTTEEVDYYVDTITDVVRAEIGID
                     "
     gene            28578..28952
                     /locus_tag="ACL8AS_000550"
     CDS             28578..28952
                     /locus_tag="ACL8AS_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1149 family protein"
                     /protein_id="HGS1228464.1"
                     /translation="MNLKREQEFVSQYHFDARNFEWENENGAPETKVDVNFQLLQHDQ
                     ENQVTSLIVILSFMIVFDKFVISGTISQVNHIDGRIVNEPSELNQEEVETLARPCLNM
                     LNRLTYEVTEIALDLPGINLEF"
     gene            28954..29802
                     /locus_tag="ACL8AS_000551"
     CDS             28954..29802
                     /locus_tag="ACL8AS_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HGS1228465.1"
                     /translation="MKLAVFTDSSAYLSEETLQREDLFVLDIPVNIDGEEYVEGINLS
                     AEEFYQKMAQASELPKTSQPSIAKLDEILTSLKEQGYTHALGLFLSSGISGFYQNIQY
                     MVDDYEGLTIAFPDTLITSAPLGIMVESVFNWRDQGDDFASIQDKLAIQISRTSAFIM
                     VDDLDHLVKGGRLSNGAAILGNLLSIKPILYFNDQGVIEVYEKVRTEKKATKRLIEII
                     KETTASGQYRVIVIHGNAPEKAEELRQHLLDFGLGSDVSLATFGSVIGTHLGAGSIAL
                     GYIPVI"
     gene            30079..30846
                     /gene="dapB"
                     /locus_tag="ACL8AS_000552"
     CDS             30079..30846
                     /gene="dapB"
                     /locus_tag="ACL8AS_000552"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008839 - 4-hydroxy-tetrahydrodipicolinate
                     reductase [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HGS1228466.1"
                     /translation="MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQ
                     DIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELK
                     EFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKT
                     AELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGL
                     TLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL"
     gene            30843..32042
                     /locus_tag="ACL8AS_000553"
     CDS             30843..32042
                     /locus_tag="ACL8AS_000553"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0001680 - tRNA 3'-terminal CCA addition
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HGS1228467.1"
                     /translation="MRLTQMPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHNPIH
                     DVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSA
                     VSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDA
                     LRIMRGFRFQASLGFALEPETFKAMKTLTPLLENISVERTFVEFDKLLLAPFWRRGLA
                     SMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKS
                     WKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAI
                     TEKYQSLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIH
                     AYLREKK"
     gene            32039..33910
                     /locus_tag="ACL8AS_000554"
     CDS             32039..33910
                     /locus_tag="ACL8AS_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001279112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HGS1228468.1"
                     /translation="MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTT
                     LLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIRE
                     YELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGL
                     RRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDAL
                     STRIFELDRAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQAR
                     ATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQAVSFAYENKPILQD
                     FNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTKGQVVIGETVRIAYFSQQIEGLD
                     ESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLL
                     KLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAF
                     EDGKIRPFFGHYTDYLDEKAFETDMANQVQKAEKEKVVKVREDKKRMTYQEKQEWASI
                     EGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS"
     gene            complement(34053..35237)
                     /gene="mntE"
                     /locus_tag="ACL8AS_000555"
     CDS             complement(34053..35237)
                     /gene="mntE"
                     /locus_tag="ACL8AS_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDF family manganese efflux transporter MntE"
                     /protein_id="HGS1228469.1"
                     /translation="MKQSISNLKLAERGAIISISTYLILSAAKLATGHLLHSSSLVAD
                     GFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRD
                     TIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKTAAKDNLSDA
                     VTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLED
                     YQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERF
                     GVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQM
                     DKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETK
                     KE"
     gene            35541..38237
                     /locus_tag="ACL8AS_000556"
     CDS             35541..38237
                     /locus_tag="ACL8AS_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HGS1228470.1"
                     /translation="MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHN
                     ELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAF
                     GVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLR
                     LIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVV
                     NTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKN
                     PLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIA
                     SDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIG
                     DPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGA
                     PDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLT
                     SEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGI
                     IDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAM
                     TGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNI
                     QKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGV
                     MNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALT
                     MAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGI
                     FHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI"
     gene            38250..39041
                     /gene="yghU"
                     /locus_tag="ACL8AS_000557"
     CDS             38250..39041
                     /gene="yghU"
                     /locus_tag="ACL8AS_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_process: GO:0006749 - glutathione metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-dependent disulfide-bond
                     oxidoreductase"
                     /protein_id="HGS1228471.1"
                     /translation="MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQ
                     LYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPAL
                     LDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFG
                     HFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLV
                     QGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK"
     gene            39157..39567
                     /locus_tag="ACL8AS_000558"
     CDS             39157..39567
                     /locus_tag="ACL8AS_000558"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HGS1228472.1"
                     /translation="MEKKIVKDILFLSQVSQPASQEDLYLARDLQDTLLANRDTCVGL
                     AANMIGVQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRL
                     AYRDSKWQEQTITLTGFPAQICQHELDHLEGRII"
     gene            39579..41174
                     /locus_tag="ACL8AS_000559"
     CDS             39579..41174
                     /locus_tag="ACL8AS_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000822862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228473.1"
                     /translation="MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILF
                     GFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSM
                     FQAKNYANVVTVTEKDFTEFPRSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAAD
                     TYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYS
                     DSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVII
                     LDATNGETKEYSLSDVPEWVDRVYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTK
                     GYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEG
                     AVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEML
                     SKYANKNDLEIDNATTESIKGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPY
                     LENGKTFEGQVGKDNYLKTFKVQ"
     gene            41341..41505
                     /locus_tag="ACL8AS_000560"
     CDS             41341..41505
                     /locus_tag="ACL8AS_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000508323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YczI family protein"
                     /protein_id="HGS1228474.1"
                     /translation="MGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGTALV
                     LVAVWLGWPK"
     gene            41584..42312
                     /gene="yaaA"
                     /locus_tag="ACL8AS_000561"
     CDS             41584..42312
                     /gene="yaaA"
                     /locus_tag="ACL8AS_000561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HGS1228475.1"
                     /translation="MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLES
                     FYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHV
                     FITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSS
                     EFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARR
                     LNFAGFVYREDLSQPQGLVFVKEV"
     gene            complement(42590..43138)
                     /locus_tag="ACL8AS_000562"
     CDS             complement(42590..43138)
                     /locus_tag="ACL8AS_000562"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="HGS1228476.1"
                     /translation="MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALP
                     LFSQDLEVPTYPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDT
                     RGVSALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKL
                     VLEETVLNSLEKQAQDLVEAIK"
     gene            43459..43947
                     /locus_tag="ACL8AS_000563"
     CDS             43459..43947
                     /locus_tag="ACL8AS_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5590 domain-containing protein"
                     /protein_id="HGS1228477.1"
                     /translation="MKKRQNKAKNNLLWQYGLGMTILFVVISASFLYMVSLSMKPYQT
                     AKSEGEKLAQQYAGLEKADQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQ
                     LNQGISQEKAETVSKEKGAGEIDKITFGRYQDKPIWEVKSGSDFYLVDFETGALVNKE
                     GL"
     gene            43944..45131
                     /locus_tag="ACL8AS_000564"
     CDS             43944..45131
                     /locus_tag="ACL8AS_000564"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008483 - transaminase activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HGS1228478.1"
                     /translation="MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTT
                     PKNIQDAAIASIRDGRASFYTVTSGLPELKAVVNSYFERFYGYSVASNQVTVAAGAKY
                     SLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAA
                     RTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTP
                     ISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQ
                     YAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAME
                     MKGYTDVTDFTTAILEEAEVALVTGAGFGASENVRLSYATDLDTLKEAVERLKAFMGS
                     END"
     gene            45124..45489
                     /locus_tag="ACL8AS_000565"
     CDS             45124..45489
                     /locus_tag="ACL8AS_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HGS1228479.1"
                     /translation="MIDHFEIKVKDLQISEGFYRSFLAPLDYKMTFKTSSLISFLSPN
                     SPHPGGDFWLTQGTQDPVHFAFLAENKEEVQACYEAGLEAGGRDNGAPGYRSEHPIYY
                     AAFMIDLDGNNIEVVCHKE"
     gene            45505..46851
                     /gene="asnS"
                     /locus_tag="ACL8AS_000566"
     CDS             45505..46851
                     /gene="asnS"
                     /locus_tag="ACL8AS_000566"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004816 - asparagine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HGS1228480.1"
                     /translation="MMTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTA
                     FFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITD
                     IEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGF
                     MKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRA
                     EKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTE
                     LLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPT
                     FVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDEL
                     GMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP"
     gene            47004..47294
                     /gene="rpsF"
                     /locus_tag="ACL8AS_000567"
     CDS             47004..47294
                     /gene="rpsF"
                     /locus_tag="ACL8AS_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HGS1228481.1"
                     /translation="MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWE
                     KRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA"
     gene            47306..47776
                     /gene="ssbA"
                     /locus_tag="ACL8AS_000568"
     CDS             47306..47776
                     /gene="ssbA"
                     /locus_tag="ACL8AS_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein SsbA"
                     /protein_id="HGS1228482.1"
                     /translation="MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGER
                     EADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQM
                     LESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF"
     gene            47808..48047
                     /gene="rpsR"
                     /locus_tag="ACL8AS_000569"
     CDS             47808..48047
                     /gene="rpsR"
                     /locus_tag="ACL8AS_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HGS1228483.1"
                     /translation="MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKI
                     LPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED"
     gene            48342..49742
                     /locus_tag="ACL8AS_000570"
     CDS             48342..49742
                     /locus_tag="ACL8AS_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional Cof-type HAD-IIB family
                     hydrolase/peptidylprolyl isomerase"
                     /protein_id="HGS1228484.1"
                     /translation="MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLRE
                     KGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSYVEEYI
                     SWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFED
                     KGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDG
                     LNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQV
                     DIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMI
                     QGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLP
                     YSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDVIAAVETGAM
                     DKPVEDVVIETIEIED"
     gene            49744..50103
                     /locus_tag="ACL8AS_000571"
     CDS             49744..50103
                     /locus_tag="ACL8AS_000571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HGS1228485.1"
                     /translation="MKIGYKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENI
                     HETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRR
                     MLPIWTGEALHHLKKKK"
     gene            50157..50906
                     /locus_tag="ACL8AS_000572"
     CDS             50157..50906
                     /locus_tag="ACL8AS_000572"
                     /EC_number="2.1.1.223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008170 - N-methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016430 - tRNA
                     (adenine-N6)-methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HGS1228486.1"
                     /translation="MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPR
                     FPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVI
                     CDDLKNMPAHIQGSKVDMILCNPPYFKVDPYSNLNESEHYLLARHEITTNLEEICHSA
                     QSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDG
                     STSGFKVLPPLIVHNDDGSYTPEIEEIYYGS"
     gene            50896..51195
                     /locus_tag="ACL8AS_000573"
     CDS             50896..51195
                     /locus_tag="ACL8AS_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HGS1228487.1"
                     /translation="MDHKAYMYVLECRDGSYYIGYTTDVRRRLAIHNSGKGAKYTRAR
                     LPVKLIYAQGFASKEEAMSAEALLKRKKRPQKEEFLSENQDRNLLSYFEESWGVL"
     gene            51266..52201
                     /locus_tag="ACL8AS_000574"
     CDS             51266..52201
                     /locus_tag="ACL8AS_000574"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004427 - inorganic diphosphate
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="manganese-dependent inorganic pyrophosphatase"
                     /protein_id="HGS1228488.1"
                     /translation="MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPN
                     EETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRV
                     ANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTT
                     HPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRV
                     AQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKV
                     EAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA"
     gene            52288..52800
                     /locus_tag="ACL8AS_000575"
     CDS             52288..52800
                     /locus_tag="ACL8AS_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000892254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YiiX/YebB-like N1pC/P60 family cysteine
                     hydrolase"
                     /protein_id="HGS1228489.1"
                     /translation="MLENGDLIFVRDGSDMGQAIQTSTGNYSHVAIYLDGMIYHASGQ
                     AGVVCQEPADFFESNHLYDLYVYPEMDIQSVKERACKHLGAPYNASFYPDAAGFYCSQ
                     YIAEILPIFETIPMKFGDGEQEISDFWREYYIELGLPVPLNQAGTNPSQLAASPLLQC
                     KERNLHDSDF"
     gene            52784..53427
                     /locus_tag="ACL8AS_000576"
                     /pseudo
     CDS             52784..53427
                     /locus_tag="ACL8AS_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000614495.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1803 domain-containing protein"
     gene            53533..53727
                     /locus_tag="ACL8AS_000577"
     CDS             53533..53727
                     /locus_tag="ACL8AS_000577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HGS1228490.1"
                     /translation="MSLENKLEQATGAVKEGFGKVTGDSKTELEGAVEKTVAKAKDVV
                     EDAKGAVEGAVEGLKNVFTK"
     gene            complement(53773..55218)
                     /locus_tag="ACL8AS_000578"
     CDS             complement(53773..55218)
                     /locus_tag="ACL8AS_000578"
                     /EC_number="6.3.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-
                     lysine ligase"
                     /protein_id="HGS1228491.1"
                     /translation="MIKIETVLDILKKDGLFREIIDQGHYHYNYSKVIFDSISYDSRK
                     VTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYEVDIPVIIVNDIKKAMSLIAME
                     FYGNPQEKLKLLAFTGTKGKTTATYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALT
                     TPESIDLFDMMNQAVQNDRTHLIMEVSSQSYLVKRVYGLTFDVGVFLNISPDHIGPIE
                     HPSFEDYFYHKRLLMENSRAVIINSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKA
                     FSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATRVPGRMEV
                     LTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLN
                     QHPEIQVFLTADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAV
                     IIAGKGADCYQIIQGKKESYPGDTAVAENYL"
     gene            55324..56946
                     /locus_tag="ACL8AS_000579"
     CDS             55324..56946
                     /locus_tag="ACL8AS_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligosaccharide flippase family protein"
                     /protein_id="HGS1228492.1"
                     /translation="MSHENNHQQAQMLRGTAWLTASNFISRLLGAVYIIPWYIWMGAY
                     AAKANGLFTMGYNIYAWFLLVSTAGIPVAVAKQVAKYNTMREEEHSFALIRSFLGFMT
                     GLGLVFALVLYVFAPWLADLSGVGKDLIPIMQSLAWGVLIFPSMSVIRGFFQGMNNLK
                     PYAMSQIAEQVIRVIWMLLATFIIMKLGSGDYLAAVTQSTFAAFVGMVASFAVLIYFL
                     AQEGSLKRVFETGDKINSKRLLVDTIKEAIPFILTGSAIQLFQILDQLTFINSMSWFT
                     NYSNEDLVVMFSYFSANPNKITMILISVGVSIGSVGLPLLTENYVKGDLKAASRLVQD
                     SLTLLFMFLLPATVGVVMVGEPLYTVFYGKPDSLALGLFVFAVLQSIILGLYMVLSPM
                     LQAMFRNRKAVLYFIYGSIAKLVLQLPTIALFHSYGPLISTTIALIIPNVLMYRDICK
                     VTGVKRKVILKRTILISLLTLVMFLLIGTIQWLLGFFFQPSGRLWSFFYVALVGAMGG
                     GLYMVMSLRTYLLDKVIGKAQADRLRAKFKLS"
     gene            57149..59107
                     /locus_tag="ACL8AS_000580"
     CDS             57149..59107
                     /locus_tag="ACL8AS_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1228493.1"
                     /translation="MKKSKSKYLTLAGLVLGTGVLLSACGNSSTASKTYNYVYSSDPS
                     SLNYLAENRAATSDIVANLVDGLLENDQYGNIIPSLAEDWTVSQDGLTYTYKLRKDAK
                     WFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGV
                     KALDDQTVQYTLVKPELYWNSKTLATILFPVNADFLKSKGDDFGKADPSSILYNGPFL
                     MKALVSKSAIEYKKNPNYWDAKNVFVDDVKLTYYDGSDQESLERNFTAGAYTTARLFP
                     NSSSYEGIKEKYKNNIIYSMQNSTSYFFNFNLDRKSYNYTSKTSDIEKKSTQEAVLNK
                     NFRQAINFAFDRTSYGAQSEGKEGATKILRNLVVPPNFVSIKGKDFGEVVASKMVNYG
                     KEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDKTVEVTDKVGIQGV
                     SSIKQSIESVLGSDNVVIDIQQLTSDEFDSSGYFAQTAAQKDYDLYHGGWGPDYQDPS
                     TYLDIFNTNSGGVLQNLGLEPGEANDKAKAVGLDVYTQMLEEANKEQDPAKRYEKYAD
                     IQAWLIDSSLVLPSVSRGGTPSLRRTVPFAAAYGLTGTKGVESYKYLKVQDKIVTTDE
                     YAKAREKWLKEKEESNKKAQEELAKHVK"
     gene            59279..59479
                     /locus_tag="ACL8AS_000581"
     CDS             59279..59479
                     /locus_tag="ACL8AS_000581"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228494.1"
                     /translation="MKLKLLRVDTKVIMGSFLLVLSSLLALLLPLILKGLIDGSSIEN
                     IGSKVFQSYWSSLVFFYWLLSV"
     gene            59448..60361
                     /locus_tag="ACL8AS_000582"
                     /pseudo
     CDS             59448..60361
                     /locus_tag="ACL8AS_000582"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
     gene            60283..60942
                     /locus_tag="ACL8AS_000583"
     CDS             60283..60942
                     /locus_tag="ACL8AS_000583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1228495.1"
                     /translation="MFNFQGAKIAFVGPSGSGKSTIVRLLERFYKPLSGDILMEQSSI
                     YDFNLKEWRSKIAWVSQNNAVLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDEIRS
                     MKEGLDTEVGERGRFLSGGQSQRLQIARTYLKDAEILIFDEATANLDADSEYAIISSL
                     YSVLKEKTVVIIAHSLSTVKDVDCIFFLEEGKITGSGTHKELLENHERYARFVQEQMI
                     E"
     gene            61099..62193
                     /locus_tag="ACL8AS_000584"
     CDS             61099..62193
                     /locus_tag="ACL8AS_000584"
                     /EC_number="2.5.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HGS1228496.1"
                     /translation="MSKELHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGRST
                     GFDYTRTKNPTRSKAEEVLATIESADYALATSSGMSAIVLAFSGFPVGSKVLAVRDLY
                     GGSFRWFNQVEQEGRFHFTYANTEEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAK
                     LAHAKGAKVVVDNTFYSPIYQRPIEDGADIVLHSATKYLAGHNDVLAGVVVTNSLELY
                     EKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTANAQEVVAFLKDSPAVKEVLY
                     TGRGGMISFKVADETRIPHILNSLKVFSFAESLGGVESLITYPTTQTHADIPAEVRHS
                     YGLTDDLLRLSIGIEDARDLIADLRQALEG"
     gene            62201..63367
                     /locus_tag="ACL8AS_000585"
     CDS             62201..63367
                     /locus_tag="ACL8AS_000585"
                     /EC_number="4.4.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_function: GO:0047804 - cysteine-S-conjugate beta-lyase
                     activity [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MalY/PatB family protein"
                     /protein_id="HGS1228497.1"
                     /translation="MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPE
                     IRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAI
                     QTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDGLFEIDFDQLEKDLVEEE
                     VKLYILCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTI
                     NPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLA
                     TEAAYRYGKDWLEELKQVFEDHINYVVDLFGKETKIKVMKPQGTYLIWLDFSAYDLTD
                     ETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR"
     gene            63460..66558
                     /locus_tag="ACL8AS_000586"
     CDS             63460..66558
                     /locus_tag="ACL8AS_000586"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HGS1228498.1"
                     /translation="MAKLIPGKIRIEGVALYETGKVDIIKEKNNRLYARVAEEELRYS
                     LEDDLVFCACDFFQKRGYCVHLAALEHFLKNDERGQEILWSLEEGHEEKEAVETKVTL
                     GGKFLDRILSPKSECAYELSAVGQVEAGTNHILWTLRIGQINSQKYYVIRDIPLFLRI
                     VEQRKSYMIGKIYEESLSWEAFDDASQELLTFLHGLTEEGLVSDLFFQNQGRHLFFPL
                     TFFEQGVNLLMALPHFQFDHQVDSYQTLLFQDMHADANLFAFTVTEYSDYFEMEISES
                     PRVNVFYQGAVLFHKGQVYFLTDQQMRLLKEIKALPVGQQGKKYLQFDSSDRDKLASC
                     LTLFIQMGTVSAPERLQIKTFAPSFYFDREEDNRIRLEIQFDYGNRQVSSRQELEELP
                     FSSDADLEERIFQVCLAAGFEADFQSWRQALKAESVYHFFHDIIPVFEKLGHVDLSDK
                     LEELYSLASPQVQIASKGGLLEIQFDFQDIAQEEIDQAMQALVANQDFYIDSSNQVYF
                     FDEETKKIRQNLQELGQFELKDGTLQARKSLAYSLAHLFEGRDRVSFSQEFQNLAQDL
                     THPEDFPRQATQVQADLRDYQEKGIGWLQMLHHYGFGGILADDMGLGKTLQTIAFLTS
                     QVTKESRVLILAPSGLIYNWADEFQKFAPQLDVAVVHGLKASREEILAESHQIYVTSY
                     ATFRQDSEFYQGMAFDFLFLDEAQVMKNAQTKIAQTLRQFVVPSVFALSGTPIENHLG
                     ELWSIFQIVMPGLLPSKKEFMKLPAERVAQFIKPFVMRRKKEEVLTELPDLIEVVYKN
                     ELEDQQKAIYLAQLQQMRDHLAQVSEQEFQRSRVEILSGLMRLRQICDTPALFMEDYQ
                     GASGKLDSLRDLLVQVADGGHRVLIFSQFKGMLEKIEQELPDLGLTSFKITGSTPAKE
                     RQDMTKAFNQGERDAFLISLKAGGVGLNLTGADTVILVDLWWNPAVEAQAIGRAHRMG
                     QEETVEVYRLVTKGTIEEKIQELQEQKKHLVSQVLDGTESRGSLTLAEIREILGISEA
                     ST"
     gene            66606..67223
                     /locus_tag="ACL8AS_000587"
     CDS             66606..67223
                     /locus_tag="ACL8AS_000587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HGS1228499.1"
                     /translation="MKQERFPLVSDDEVMLTEMPVMNLYDESDLISNIKGEYRDKNYL
                     EWAPITEEKPVKPIEKQVEKPKKAPLGVKKEGKSYAEVAREEARADLKKKRSANYLTQ
                     DFSLARRHSQPSLVRQGNQPTTPFQKENPGEFVKYSQKLTQSHYILAEEVHSIPTKNE
                     EVSAPAPKKNNYDFLKKSQIYNKKSKQTEQERRVAQELNLTRMTE"
     gene            67234..68568
                     /gene="murC"
                     /locus_tag="ACL8AS_000588"
     CDS             67234..68568
                     /gene="murC"
                     /locus_tag="ACL8AS_000588"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008763 - UDP-N-acetylmuramate-L-alanine
                     ligase activity [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HGS1228500.1"
                     /translation="MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGL
                     EQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRD
                     FVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
                     MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDA
                     PIYYYGFEAEGNDFVASDLLRSTTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIG
                     LLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKY
                     PSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLAN
                     KINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ"
     gene            68578..69042
                     /locus_tag="ACL8AS_000589"
     CDS             68578..69042
                     /locus_tag="ACL8AS_000589"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228501.1"
                     /translation="MEIPIKIIQASKSDLPEIGALQTSSFPAEKQQLSHILEESIRKC
                     ADTFLLARDENQLLGYILSSPQSDNPQCLKVHSLVIESDHQRQGLGTLLLAALKEVAV
                     ELDCKGIRLESPDELLSYFEMNGFVDEEETLLYATSQGYSMIWFNPFYLEEQ"
     gene            69039..69533
                     /locus_tag="ACL8AS_000590"
     CDS             69039..69533
                     /locus_tag="ACL8AS_000590"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228502.1"
                     /translation="MKIRQARLEDLDRIVELEFENFSVEEAIPPSVFEAHLREIQTSF
                     LVAEKEGRIMGYIEGPVGLHRHLQDQSFTEEIKDYSHEPGGYISVTCLSIAKEAQGLG
                     LGQKLLTALKEVALEDERDGINLTCHDYLIAYYEKHGFVNEGQSQSTFAGETWYDMVW
                     EMKK"
     gene            69614..71269
                     /gene="mltG"
                     /locus_tag="ACL8AS_000591"
     CDS             69614..71269
                     /gene="mltG"
                     /locus_tag="ACL8AS_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008932 - lytic endotransglycosylase
                     activity [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HGS1228503.1"
                     /translation="MSEKSREEEKLSFKEQILRDLEKVKGYDEVLKEDEAVVRTPANE
                     PSAEELMADSLSTVEEIMRKAPTVPTHPSQGVPASPADEIQRETPGVPSHPSQDVPSS
                     PAEESGSRPGPGPVRPKKLEREYNETPTRVAVSYTTAEKKAEQAGPETPTPATETVDI
                     ISDTSRRSRREGAKPVKPKKEKKSHVKAFVISFLVFLALLSAGGYFGYQYVLDSLLPI
                     DANSKKYVTVGIPEGSNVQEIGTTLEKAGLVKHGLIFSFYAKYKNYTDLKAGYYNLQK
                     SMSTEDLLKELQKGGTDEPQEPVLATLTIPEGYTLDQIAQTVGQLQGDFKESLTAEAF
                     LAKVQDETFISQAVAKYPTLLESLPVKDSGARYRLEGYLFPATYSIKESTTIESLIDE
                     MLAAMDKNLSPYYSTIKSKNLTINELLTIASLVEKEGAKTEDRKLIAGVFYNRLNRDM
                     PLQSNIAILYAQGKLGQNISLAEDVAIDTDIDSPYNVYKNVGLMPGPVDSPSLDAIES
                     SINQTKSDNLYFVADVTEGKVYYANNQEDHDRNVAEHVNSKLN"
     gene            71340..71822
                     /gene="greA"
                     /locus_tag="ACL8AS_000592"
     CDS             71340..71822
                     /gene="greA"
                     /locus_tag="ACL8AS_000592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HGS1228504.1"
                     /translation="MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDL
                     SENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAQDEVAIGKTVTIQEIGEDE
                     EEVYIIVGSAGADAFAGKVSNESPIGQALIGKKTGDTATIETPVGSYDVKILKVEKTA
                     "
     gene            72195..72593
                     /locus_tag="ACL8AS_000593"
     CDS             72195..72593
                     /locus_tag="ACL8AS_000593"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228505.1"
                     /translation="MENKESHKSQEIGNLIRVYNRSKREEAESEPLNLYVEDEKGNLL
                     AGLIAETFGNWLEIEYLFVKEELRGQGIGSKLLQQAESEAKNRNCCFAFVNTYQFQAP
                     DFYQKHGYKEVFSLQDYLYIRQRYYYQKNL"
     gene            73024..>73464
                     /locus_tag="ACL8AS_000594"
     CDS             73024..>73464
                     /locus_tag="ACL8AS_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1228506.1"
                     /translation="MILQKANKGKSNREIASLLGKVPQTIHTEIKRGTVRQCLGKGRF
                     KEVYSADYAQQSYENNRKRSVRKLSVTKELKEKILHYHNQKFSPEMMVMAKGVNVGIS
                     TIYYWIHHGKLGLSKQDLLYPRKGKALKKQASINFKPAGQSIAQR"
BASE COUNT        21802 a        13698 c        16651 g        21313 t
ORIGIN      
        1 attttcctca ttttctagtg aaattgaact ttttctaaca tcttttgata gatgacttct
       61 taatcaatta tcatttccat tgttgtttct tggggtttca tcccttgtct ttgataaaag
      121 cggagagcac cctcgttatc attccagaca cttagggtta gattattgca gccaatttct
      181 ttagcataat agcagaaaaa tgacaataaa atagccccta gatattttga aaggaaagca
      241 taggggctat atagtttaat caaaataaag caaatctttg ctggtgcttg taaagaggtc
      301 gaagccatcc ttggtaacaa caccgcagtc ttcaatacga acaccgactt taccagggat
      361 atagatacct ggttcaacag agaagcacat gccttcttcg atgaccatgt cgtttccttc
      421 catgatagat gggaattcat ggacatccat accgatacca tgcccgagac ggtgattgaa
      481 gtactcacca taaccagctt tttcgatgac ctcacgggca gcgcggtcca cttcatgagc
      541 agtcacacct ggcttgataa agtcaagagc agcttgttgg gcttcaagag tcaagttgta
      601 aatatctttc ttgaattggt ctggtttgcc gacagcgact gtacgagtca tatctgacgc
      661 atagccattg accagaacac ccaggtcaaa gaggagaaga gcatcatttt caaccttatt
      721 agctgctgga atgccgtgtg gattcgcagc attatcacca gtcaagacca tggtatcaaa
      781 gctcatttca taaccttcac gtttcatggc aaagtcgatt tgtgcgatga tatctgtctc
      841 agtcttatca agagaaatat tgtcaaaacc aacatgaaca gccttgtcag cataaagacc
      901 tgcaaccatc attttttgca cttcatcagc tgatttgatg aggcgcatgc gttggatacg
      961 aggagtgagg ttgtcaaact cagcagtctc aaaaactgtt ttcaaaccat ggtatttggt
     1021 caagatgaga ttgtcaaact caacagcgac acgtttgaag tcaagttgtg gaagagcatg
     1081 tttgattttt tgccatggat tttcagaatc gacatagccc actactggga aggaaacggt
     1141 gctacttgca cgttctactt caagagctgg gacaaagagg agaggttcct gatccgctag
     1201 gacaaagagg aacatttggc gttcatgggg atcactgtaa aaaccagtga ggtaattgat
     1261 tgtgacgggg tcagatacga cagcgacgtc tagtttttct gattcaagat atgttaggat
     1321 ttgttgtaat ttagacatat gctaccttct ttctacccct ctattttggc aaaaaatgag
     1381 agaaaatgca agggagaagg gtaaaagaaa agacaaaaaa ctccgacaag ataacggagt
     1441 tctttgatat cattttcctt tgtttaagaa aagtcagcct tgcttttgac gtcactgtac
     1501 tcttcagcga tttcttggct gaggatatcc tcataggcag ggagttggat atcctgacca
     1561 tatttcttct tgagggcagt agtaactagg cgataagcca gattggcatt acgagagagg
     1621 ataggcccgt ggaagtagga accaaagaca ttcttataat gaaccccttc accgaccttt
     1681 tcttcgttgt ttccatttcc atagacaacc tgtcccagcg gtttttggtc atcagagagg
     1741 aaggtacggc cttggtgatt ttcaaatcca tagtaggttt catcgaaatc ttcattgtga
     1801 atcttgatgt caccgataaa acggttattg gtctggttga gcgtgtagtg tcccatgacc
     1861 cctagccctt cgatacgttt tcctgaagct tcaacataat attgacccaa tagttggaaa
     1921 ccaccgcaga tagccagaac tacaccgtcg ttttggatgt agttgtcaat gctctctttt
     1981 ttagcaggta ggtcgtctgc aatgatactt tgttcaaagt cttgaccacc accgaaaaag
     2041 gcgatgtcgt agtgattttc atcaaagtca tcatggagag aaacgatgtc aacggtcaca
     2101 tgggctccca gtttttcagc cacatatttg agcatgagga tgtttccatt gtccccgtag
     2161 gtattcatga gatttccgta gaggtgggca atgttgagct gataggggta attgccatct
     2221 tttgaggaaa gtgaagtata aaccattagt tcatctcctt tctaacaatc tgacgactag
     2281 ccagcagttc acgaaattcc agcatggcag tataagttgc cagaatatag gcatgcttgc
     2341 agtcttgatt ctcaatggtc ttgagaactt gctccagatt actcgtttca gtgattttct
     2401 cagctggata gccagtcact cggaggcgac gagcgatttc agaatgacga acaccgccag
     2461 cgttgatttc aggaatgtcc atgtcagtga tttgctcaaa gtctgcatcc cagatccagc
     2521 tagtgtcaat tccatctgca tagttggcat taaggaggac agataggcta aatggataag
     2581 gtgctagttt gatcatttcg atagcttggg ttgcaccgac tggattttta atcaagacaa
     2641 gggtacattc cttgtcaccg atatgaaagg tttcttggcg tccaaagaca gcacggctct
     2701 tgtcaaatcc ctgtttgatg agttgcgaat cggcacctag gaaacgggcg atggccacag
     2761 cagctagggc gttatagata ttatagagcc cgccgatttg gataccgtat tcttggccgt
     2821 ctatgacaaa gcgagagcga ttgttggtca actcaaccag ttttgtcaaa cgatagtcga
     2881 gatcaggacg tttgcatcca caaccttcac agatataggc acccaagttt gcataggtat
     2941 tatgctcata tttgaggatg ccttggcagt caggacagag aatcccttcg gtattgtagt
     3001 gagccagttg ggctggtcct ttttccaagt caaaaccaaa atactctata gggtttggaa
     3061 tagttggctt gtagaaaagt ggactgtctc cgttaaggag aacagtagca gttggaactt
     3121 tccgaatggc ttccaatatc atgttatagg tagtatagat ttcaccgaaa cggtccatct
     3181 ggtcacggaa gatattagta atgacaaaaa gactaggctg gatatagtca cagatacgag
     3241 atagactggc ttcgtcaatt tcgaggacgg caatattttt cccagttttt gaagatttgg
     3301 ctgttaggaa ggttgttgca atccctgtaa tcatgttggc accgcttggg ttggttagaa
     3361 cttgaccata aacctctttt aaaatgccga cagtgagggc agttgtcagg gtttttccat
     3421 ttgttccagt gacaacgaca atctcgtagt tcttagctag gttttgtaaa atatctttat
     3481 caaattgaag ggcgacttta cctgggagcg tacttccacg gccaagacgg cttaaaatga
     3541 agtgggaaga acgcccagca agaaggccca aagtagtttt taagttcatg tttctattat
     3601 atcataaaag aggagaaaga cagatttgag attccgcaga agtaaaaaca gcccaaagag
     3661 ggctgttcga tacgattaaa tctcaactta aatcgcaaac aagtcattca agttctcagc
     3721 caaggttggg tgagtgaaga tttgttttgt gaagtaagtg taaggaatct tgttgtccat
     3781 agcaacagtg atgatgttga tgatttcttg agaaccttct gagaagatgc ttgctccaag
     3841 aatttctttt gtttcagtat tgacaacagc tttgaaggca ccgcgaaggt ctccatttac
     3901 gtgaccacga ggcattgctg caacggggat ttccttaaca gcgtatggaa gtttcaaatc
     3961 agctgcttgg ctttcagtca aaccaacttg tgaaagtgca ggtgtgatga acatagtatt
     4021 tggcacattg agacggtctt caagtgtgta gctgccatct ccagcaaggt agctgtaaac
     4081 aacacggaag tcatcaagtg aaatgtaagt aaattgaagg ccaccgttga catctccaac
     4141 tgcaaagaca ccaggaacgt ttgtttgaca gtgtttgtct actttaatag caccacgttc
     4201 agttagttca atatctgtat tttcaagttg aagtggttct acatttggtt tgcgtccagt
     4261 tgcgtagaga agggcgtcga aacggtaagt ttcgtcttca gttacgacaa gcacttggtc
     4321 accatcgttt ttgatttcag tagtatggat attttgaagc aattcaatgc catcttcttc
     4381 catgtattgt ttagcaagag ctgcgatgga aggttctgca cgaggtagga atgtatccaa
     4441 ggcatctagg actgtgacct tgcttccaag tttgttgtaa aggccggcaa attcaagacc
     4501 gatatttccg ccaccaagga ttccaagttt ttcaggtaat ttgtccaagc tttggatacc
     4561 tgttgagtca aagatgtttt tgcttgtagc aagtccaggg attggcaaga cgtttgaaac
     4621 agcaccagtg ttgatgacga ttgtttcagc agtcagttct ttcttttcat caccagcttg
     4681 gatttcgatg actttatttg aaaggaagtg agcttccgca tcaaagatat ctacgcctgt
     4741 accagcaaca gtcgcatagt ttttaccgtt gaggcgacca gtgatcgtgt ttttagtagc
     4801 aatcacttct tcaaaagaca agtccttttc agcagcaact agcaaggttt tagttgggat
     4861 acaaccaatg ttgatacaag ttccaccgta catagccttg ctgcgttcaa cgagggcaac
     4921 ttttttgcca gctgaagcca atttacctgc tagtgtttta ccagctttac caaatccaat
     4981 aacaattaaa tcgtatgtta acatttatct tcctcctatt cgaatttcat tctagcacaa
     5041 gaaaaaaact tttgcacaat tctgctacgg aaaagacaga aaaagataaa aacgctttcc
     5101 agacaaaaaa ctagtaattt tttgacaagc ttgataaact aaaatcctat ctatttttat
     5161 ataagataga ataaatgttc gaaaatagga ggttttatga aatcgaatcg ttatattatt
     5221 gcctttgctg gggtcatttt acacttaatg ctgggttcga cttatgcttg gagtgtttat
     5281 cgtaacccta ttattgaaaa aacgggatgg gatcaggctt ctgttgcctt tgcctttagt
     5341 ctagcaatct tttgtttggg cttatcggct gcatttatgg ggcgtttggt agaaaaattt
     5401 ggtccgagag tcatggggag tctatctgct tttctatacg caggtggaaa tatcttaaca
     5461 ggatttgcaa tagaccgtca ggaactgtgg ttgttgtatc tagcttatgg cattttaggt
     5521 gggcttggtt tgggagcagg ctatattacc cctgtgtcaa cgattataaa atggtttcct
     5581 gataaacgtg gtctcgcaac aggtttagcg attatggggt ttggttttgc ttctttattg
     5641 actagtccca tagcgcaaca tctcatcgca ggggtagggc ttgtagaaac tttttatatt
     5701 ttaggtgcaa gttactttat tatcatgctc ctagcttcac aattcattaa gcgtccaaat
     5761 gagcaagagc ttgcaatttt atctgcttca gggaaagaaa aaacagactc tctgacgcaa
     5821 gggatgactg caaatcaggc tctaaaaagc aatcggtttt atatactttg gattattttc
     5881 tttatcaaca tagcttgtgg tttaggctta atttcagcgg catcgccaat ggcacaggag
     5941 atggctggct tgtctacaag tcatgcagca gtaatggtgg gcgttttagg gattttcaat
     6001 ggatttggtc gcttgctctg ggcgagctta tctgactata tcggtcgccc tctaaccttt
     6061 agtatattac tgcttgttaa tcttttattt tctctctcac tttggctctt tacagattcc
     6121 gttttatttg tagtcgctat gtctattttg atgacttgct atggagctgg tttttcattg
     6181 atcccagctt atctcagtga tatttttgga accaaggaat tggccgctct gcatggatat
     6241 attttaacag cttgggcaat ggctggttta gcgggaccta ttttattagc agagacttat
     6301 aaaatggctc attcgtacac acaaaccttg ttcgtttttc tcattttata cagtatcgcc
     6361 ttggctttgt cttattatct aggtcgttca atcaaaaaag aaagtcaaaa accgcttaca
     6421 tgattttctg tagaaatggg gctatctttt gctctggtct tgtgttatac tagataggtt
     6481 gcaaagaaaa cagtactttt cttttgtgga aaagaagcaa cacgatttta tatctagtta
     6541 tatgaaaata cgtcataaaa agaaaagtat aaactaagcc ctatagggtg gcttcgcacc
     6601 acctttagaa agaagaataa cgtgaaattt aatgaattaa acttgtctgc tgatttgctg
     6661 gcagaaattg aaaaagctgg ttttgtagaa gctagtccta tccaagaaca aactattcct
     6721 ttggcccttg aaggcaagga tgttatcggt caagctcaga ctggtacagg aaaaactgca
     6781 gcctttggct tgcctaccct tgaaaaaatc cgtacagaag aagcgactat ccaagccttg
     6841 gtcatcgctc caactcgtga actagctgtc caaagtcaag aagaactctt ccgctttggt
     6901 cgtagtaagg gagtcaaagt ccgttcagta tatggcggat caagcattga aaaacaaatt
     6961 aaggctctta aatctggtgc ccatatcgtg gtgggaactc caggtcgcct cttggacttg
     7021 attaaacgca aggccttgaa attacaaaac attgaaaccc ttatccttga cgaagcggat
     7081 gaaatgctta acatgggctt ccttgaagac atcgaagcca ttatttcccg tgtacctgag
     7141 aaccgtcaaa ctttgctttt ctcagcaact atgccagatg ccatcaaacg tatcggtgtt
     7201 cagtttatga aagcccctga acatgtcaag attgcggcta aggaattgac aacagaattg
     7261 gttgaccagt actatatccg tgttaaggaa caagaaaaat ttgacaccat gactcgtctc
     7321 atggatgtgg cacaaccaga actcgctatt gtatttggtc gtaccaaacg ccgtgtggat
     7381 gaattgactc gtggtttgaa aattcgtggc ttccgtgcag aaggaattca tggcgaccta
     7441 gaccaaaaca aacgtcttcg tgtccttcgt gactttaaaa atggcaatct tgatgttttg
     7501 gttgcgacag acgttgcagc gcgtggtttg gatatttcag gtgtgaccca tgtctacaac
     7561 tacgatattc cacaagatcc tgagagttat gttcaccgta tcggtcgtac aggtcgtgct
     7621 ggtaagtcag gtcaatctat tacttttgtt gctccaaacg aaatgggtta ccttcaaatc
     7681 attgaaaact tgactaagaa acgcatgaaa ggtctcaaac ctgcaagtgt agaagaatcc
     7741 ttccaatcaa aaaaacaggt ggctctcaag aaaatcgaac gtgattttgc agatgaaacc
     7801 attcgtgcca actttgagaa atttggtaag gatgctcgca aattggctgc tgagtttact
     7861 ccagaagaat tggcaatgta tatcttgagt ctgacagtcc aagacccaga tagccttcca
     7921 gaagtggaga ttgcacgtga aaaaccacta ccgtttaaac catcaggtaa tggtttcggt
     7981 ggtaaagcta agggaggtcg tggaggccgt cgtggggacg accgtcgaga gcgtgatcgc
     8041 cgtggcaatg gtcgccgtga tgagttcaaa aaaggaagtc gtggcaacga tcgttttgat
     8101 aaggaaaaac gttaccgtaa ggataataaa aaaccacgca atactttaag cgaaaagcaa
     8161 acaggctttg ttattcgtaa caaaggtgat aaataagaaa aagcggttca aaatgaatcg
     8221 cttttttata taaggagacc gaatgtgaaa agacaaataa aattactata ttatctttta
     8281 taatattata atacacaaaa ataggcgact tgtcaataga aaaggaacaa tttaattaaa
     8341 aatattctgg tttttaatta aattgtaagt caatgcaagt caataaggaa ttttcagata
     8401 attattgaaa aagagacgtt tttatgttat aatgatagcg attaaattcg aggtgaaaaa
     8461 tggcacattt attagaaaaa actagaaaaa ttacatcaat tttgaaacgc tcagaggagc
     8521 agttgcagga tgagctccct tacaacgcta ttacgcgtca gttagcggat attattcatt
     8581 gcaatgcctg cattatcaat agtaagggac gtctgcttgg ctattttatg cgttataaaa
     8641 caaatacaga tcgcgtagag caattcttcc aaactaagat tttcccagat gactacgttc
     8701 aaggggctaa tatgatttac gaaacagaag caaacttgcc tgttgagcat gatatgagta
     8761 ttttccctgt tgagagtaga gatgattttc cagatggctt gacgactatt gcaccgattc
     8821 atgtatcggg gattcgcctt ggttctttga ttatttggcg taatgataaa aaattcgaag
     8881 atgaggactt ggttcttgtt gagattgcca gtaccgttgt tgggattcag cttcttaact
     8941 tccaacgtga agaagatgag aaaaatattc gtcgtcgtac tgctgtcacc atggcggtca
     9001 ataccctttc ttactccgaa ctccgtgctg tttcagcaat tttaggggaa ttaaatggaa
     9061 atgaagggaa gttgactgcg tcagtgattg cagatcgtat cggaatcact cgctctgtga
     9121 ttgtcaatgc tcttcgtaaa cttgagtctg cggggattat tgaaagtcgc tcacttggaa
     9181 tgaagggaac ctatcttaag gtcttgattt cagatatttt tgaagaagtg aagaaaagag
     9241 attactaatg acaaaggctt taatttcgat tgattataca gaagattttg ttgctgatag
     9301 tgggaagctg acagcaggtg ctccagctca ggcgatttcg gatgccatca gcaaggtaac
     9361 tcgattagct tttgaacgag gagattatat cttctttact attgatgctc atgaagaaaa
     9421 cgattgtttc catccggaaa gtaagttatt tcctcctcat aatctgattg ggacgagtgg
     9481 acggaattta tatggagatt tggggatctt ttatcaagag catggttcag acagtcgtgt
     9541 cttttggatg gataaacgcc attactcagc tttttcaggg actgacctag atattcgttt
     9601 gagagagcgt agagtgtcta ccgttatctt aacaggtgtc ttgacggata tctgtgtcct
     9661 acatacagct atagatgcct ataatctagg atatgacatc gagattgtta aaccagctgt
     9721 tgcttccatc tggcctgaaa atcatcaatt tgccctaggt catttcaaaa atacactcgg
     9781 agctaagtta gtagatgaaa atctaaatga actttctgag taacctggtt ggtgaaaatg
     9841 aaaaaatttg aaaaaaagtg ttgacaagca tcccaaaagt tgatatacta gtaaagtaat
     9901 cgatgcgggg atggcggaat tggcagacgc gcaggactaa ggatcctgtg accgctttag
     9961 gtcgtgaggg ttcaagtccc tctctccgca taggaaaaga gttagctaaa gctagctctt
    10021 ttgtatttct ctaaaaaatt agaatccagt caaatgtagt ggagaatcag cgaaaatatg
    10081 ggaaaactga tccttgtttc tgcttttgtc atagaagaat aataaagatt atcttcttca
    10141 aattctccga tattctctaa agttttgtgc aagttgcaca gaactttttt atttttttgg
    10201 tcatcttgcc atagaaatat aaagcgtttt catctataat ataattatca aaagacaaaa
    10261 ggagttcacc tcatggtaga attgaatctt aaaaatattt acaaaaaata tccaaacagc
    10321 gaacactatt cagttgaaga tttcaacttg aacatcaaag ataaagaatt tatcgttttc
    10381 gtaggacctt caggatgtgg taaatcaact acactccgta tgattgctgg tcttgaagac
    10441 atcacagaag gtactgcatc tatcgatggc gtggttgtca acgacgtagc tccaaaagac
    10501 cgtgatatcg ccatggtatt ccaaaactac gctctttacc cacacatgac tgtttatgac
    10561 aacatggctt tcggtttgaa attgcgtaaa tacagcaaag aagacattaa caaacgtgtt
    10621 caagaagcag ctgaaatact tggattgaaa gaattcttgg aacgtaaacc agctgacctt
    10681 tcaggtggtc aacgtcaacg tgttgccatg gggcgtgcga ttgtccgtga tgcgaaagta
    10741 ttcttgatgg acgaaccttt gtcaaacttg gatgccaaac ttcgtgtatc aatgcgtgct
    10801 gaaatcgcta aaattcaccg tcgtatcgga gctacaacta tctatgtaac tcacgaccaa
    10861 acagaagcga tgacacttgc agaccgtatc gttattatgt cagctactaa gaaccctgct
    10921 ggtacaggta ctatcggacg tgtagaacaa atcggtactc ctcaagaagt ttacaaaaat
    10981 ccagttaaca aatttgttgc aggattcatc ggaagcccag ctatgaattt catcaacgtg
    11041 aaattggttg gtagcgaaat tgtttctgac ggtttccgtt tgaaagtgcc agaaggagca
    11101 ttgaaagttc ttcgtgaaaa aggctacgaa ggaaaagaat tgatctttgg tatccgtcca
    11161 gaagacgtga atgcagaacc tgctttcctt gaaacattcc cagactgtgt tgtaaaagcg
    11221 actatctctg tatcagaact gcttggttca gaatctcacc tttactgcca agttggtaaa
    11281 gacgagtttg ttgcaaaagt tgatgctcgt gactacttgc aaacaggtgc aacagttgag
    11341 cttggatttg acttgaacaa agcacacttc ttcgatgtag aaactgaaaa aacaatttac
    11401 taaaataaat aaaattcaaa acactacaag aaaagatatc tctttatcaa ttgtagtgga
    11461 gagatatcag ttaatctagg gagagaaaca aaatgcttct ctcctttttg ctagggaagt
    11521 catattatgc atctatattg tgatgctctt taatactctt cgaaaatctc ttcaaaccac
    11581 gtcaacgtcg ccttgccgta cgtatgatta ctgatttcgt cagttttatc tgcaacctca
    11641 aagctgtact ttgagcagct tacggctagt ttcctagttt gctctttgat ttccattgag
    11701 tattatttgt gggtaccatc tacaagtgaa gctatatgcg taaactacgt gagcaattga
    11761 attcgaacta gagaggtaat aataaattta tgctatagtt atggtgactt gtatgctttt
    11821 gattctagtt tatcaaataa tagattagaa ttgtcagata atatcatttt gtgttataat
    11881 gaagaaaaaa cagaggtgtt caaatgtcag aagcaggtca taagttttta gcaaaattgg
    11941 ggaaaaaacg cttacgtcca ggtggaaagc gtgccacaga ttggttaatt gcagaaggag
    12001 gattttcaaa agaaaagaga atactagagg ttgcgtgtaa taggggaact acagcaattg
    12061 agttggcaca gcgttttggt tgcaagataa ctgctgttga tatggatgct caagctttag
    12121 aagtggctaa aaaatctgct ggaacggcag gtgttgctca tttaatcagt tttgaaagag
    12181 caaatgcaat gaaacttcct tatcaagatg ctagttttga tattgttata aatgaagcta
    12241 tgctgactat gcaagccgat caagctaaga aaaaatgtgt aatggaatat ctaagggtat
    12301 taaaacctgg aggtcttcta ttgacgcatg atgtgcttct taaggaagct aaagagtcta
    12361 tcagacagga attatcacaa gcaattcatg taaatgtagg tcctttaact caagatggtt
    12421 gggaacaggt gatgatagaa tcaggttatt gtgatgtgaa agtattgact ggtgaaatga
    12481 cattaatgaa attatcgggt atgatttatg acgaaggttt gctaggaact ttgaaaattt
    12541 gtgtaaatgc ttgtaaaaag gagaatagaa agcagttttt aactatgtat aaaatgtttg
    12601 ctaagaataa acagaaattg ggttttattg cgatggctag ttataaatcg tcaaaacgtt
    12661 agataattat tgaagttaac ttttcctttt ttctttctta aaaaatatgc tataatagag
    12721 agtaaaaaac tttgaaagaa agaaaaagat gaatttaaaa gattacattg caacaattga
    12781 aaattatcca aaggaaggca ttaccttccg tgatattagt cctttgatgg ctgatggaaa
    12841 tgcttatagc tacgctgttc gtgaaatcgt tcagtatgct actgacaaga aagtcgacat
    12901 gatcgtggga cctgaagctc gtggatttat cgtgggttgt ccagttgcct ttgagttggg
    12961 aattggtttt gcgcctgttc gtaagccagg taaattgcca cgcgaagtta tttctgctga
    13021 ctatgaaaaa gagtacggtg tcgatacctt gactatgcac gcggatgcca ttaagccagg
    13081 tcaacgtgtt cttattgtag atgacctttt ggcgacaggt ggaactgtta aggcaactat
    13141 cgagatgatt gaaaaacttg gtggtgttat ggcaggttgt gccttccttg ttgaattgga
    13201 tgaattgaac ggccgtgaaa aaatcggtga ctacgactac aaagttctta tgcattatta
    13261 atgaaaacag tccctagggc tgttttctct acactaggat ataaaaatag actataacta
    13321 gttagagaaa aactataatt gaaaactata tcttcttgca gtataataaa aggactaagt
    13381 gtttgagatt tgtcttcaaa catatgcaat tattcctgaa agagtacagt taggagaggg
    13441 ttatgccgat tcgaattgat aaaaaattgc cagctgttga gattttacgg acagagaata
    13501 tctttgtcat ggatgatcaa cgtgctgccc accaagatat ccgtcctttg aagattttaa
    13561 ttttaaatct catgccacag aaaatggtca cagagaccca gttgttgcgc cacttggcta
    13621 atacacccct acaactggat attgattttc tctatatgga gagccaccgt tctaaaacaa
    13681 ctcgttcaga gcacatggag accttctata aaacttttct tgaagtcaag gatgagtatt
    13741 ttgatgggat gatcatcacg ggtgctccag ttgagcattt accatttgag gaagtggact
    13801 attgggagga atttagacag atgcttgagt ggtctaagac tcatgtctat tcgacccttc
    13861 atatctgttg gggggctcag gctgggcttt atctgcgcta tggtgtagaa aaataccaga
    13921 tggacagtaa gctatcaggt atttatcctc aggacaccct aaaagagggt caccttctat
    13981 ttagaggctt tgatgatagc tatgtatctc ctcattcacg gcacacggag atttctaagg
    14041 aagaggtctt aaacaagacc aatctcgaga ttttatcaga aggacctcag gttggggttt
    14101 ctattttggc cagtcgtgat ttacgagaaa tttatagttt tggtcatttg gagtatgacc
    14161 gtgatacctt ggcaaaagag tattttcgag atcgtgatgc aggtttcgac ccacatattc
    14221 cagaaaatta ctttaaagat gatgatgtta atcaggtacc ttgtctttgt tggtcttcat
    14281 ctgcagccct ctttttcagt aattgggtaa accatgcggt ctatcaggag acgccttttg
    14341 actggagaaa gatagaagat gatgcatctg catatgggta tttataagag gaattatgac
    14401 atatttagac gcttttaaat caggtacctt ggttttaccg agtgccctgc tcttgcattt
    14461 taaggaactc tttccttcta gcgacgattt tctggtttgg caatttttct atttgcaaaa
    14521 tacgacaggc ttagaagaaa tgtcgccaag ccagattgct gaaaggattg gcaaggaaat
    14581 ttcggatgtc aaccagtcca tttctaatct gacggaaagg ggactgctcc agtatcgtac
    14641 tatcgaatta aatggcgaaa ttgaattgct ctttgatgct agtttggcct tggaacgttt
    14701 ggatgacctg tttggagcag ttcattcaag ttcagaccag ctaacacctc aaaaccagct
    14761 caaggatttg gtggaaacct tccagcagga gttgggacga ttgttgacgc cttttgagat
    14821 tgaggatttg accaagacac taaaggaaga tggaaccagt gctgacttga ttaaggaggc
    14881 tcttcgtgaa gctgttttga atggaaaacc aaactggaag tacattcagg cgattttgag
    14941 aaactggcgc catgaaggaa tcaagagtgt ggctcaaatt gaggccaaga gagcagaaag
    15001 agaagcaagc aatcctcagt tgatacaggt atctgcagat ttcagaaatg ccatggatct
    15061 ctggaaggat taatccatgc aagtaggctt gaaatccgag taagatttgc aagctgtgta
    15121 taattgtgat agaataaata gaaaataaat tgaaaaaaga ggtatgtgaa atgtcacgta
    15181 aaccatttat cgctggtaac tggaaaatga acaaaaatcc agaagaagct aaagcattcg
    15241 ttgaagcagt tgcatcaaaa cttccttcat cagatcttgt tgaagcaggt atcgctgctc
    15301 cagctcttga tttgacaact gttcttgctg ttgcaaaagg ctcaaacctt aaagttgctg
    15361 ctcaaaactg ctactttgaa aatgcaggtg ctttcactgg tgaaactagc ccacaagttt
    15421 tgaaagaaat cggtactgac tacgttgtta tcggtcactc agaacgccgt gactacttcc
    15481 atgaaactga cgaagatatc aacaaaaaag caaaagcaat ctttgcgaac ggtatgcttc
    15541 caatcatctg ttgtggtgaa tcacttgaaa cttacgaagc tggtaaagct gctgaattcg
    15601 taggtgctca agtatctgct gcattggctg gattgactgc tgaacaagtt gctgcctcag
    15661 ttatcgctta tgagccaatc tgggctatcg gtactggtaa atcagcttca caagacgatg
    15721 cacaaaaaat gtgtaaagtt gttcgtgacg ttgtagctgc tgactttggt caagaagtcg
    15781 cagacaaagt tcgtgttcaa tacggtggtt ctgttaaacc tgaaaatgtt gcttcataca
    15841 tggcttgccc agacgttgac ggtgcccttg taggtggtgc gtcacttgaa gctgaaagct
    15901 tcttagcttt gcttgacttt gtaaaataat cagtaagtag caaaagctag gtggaacagc
    15961 attcagatgt ctgttacatt ttttatagga gagcaaagat tgaaaacaaa aattggatta
    16021 gcaagtatct gtttactagg cttggcaact agtcatgtcg ctgcaaatga aactgaagta
    16081 gcaaaaactt cgcaggatac aacgacagct tcaagtagtt cagagcaaaa tcagtcttct
    16141 aataaaacgc aaacgagcgc agaagtacag actaatgctg ctgcccactg ggatggggat
    16201 tattatgtaa aggatgatgg ttctaaagct caaagtgaat ggatttttga caactactat
    16261 aaggcttggt tttatattaa ttcagatggt cgttactcgc agaatgaatg gcatggaaat
    16321 tactacctga aatcaggtgg atatatggcc caaaacgagt ggatctatga cagtaattac
    16381 aagagttggt tttatctcaa gtcagatggg gcttatgctc atcaagaatg gcaattgatt
    16441 ggaaataagt ggtactactt caagaagtgg ggttacatgg ctaaaagcca atggcaagga
    16501 agttatttct tgaatggtca aggagctatg atgcaaaatg aatggctcta tgatccagcc
    16561 tattctgctt atttttatct aaaatccgat ggaacttatg ctaaccaaga gtggcaaaaa
    16621 gtgggcggca aatggtacta tttcaagaag tggggctata tggctcggaa tgagtggcaa
    16681 ggcaactact atttgactgg aagtggtgcc atggcgactg acgaagtgat tatggatggt
    16741 actcgctata tctttgcggc ctctggtgag ctcaaagaaa agaaagattt gaatgtcggc
    16801 tgggttcaca gagatggtaa gcgctatttc tttaataata gagaagaaca agtgggaacc
    16861 gaacatgcta agaaagtcat tgatattagt gagcacaatg gtcgtatcaa tgattggaaa
    16921 aaggttattg atgagaacga agtggatggt gtcattgttc gtctaggtta tagcggtaaa
    16981 gaagacaagg aattggcgca taacattaag gagttaaacc gtctgggaat tccttatggt
    17041 gtctatctct atacctatgc tgaaaatgag accgatgctg agagtgacgc taaacagacc
    17101 attgaactta taaagaaata caatatgaac ctgtcttacc ctatctatta tgatgttgag
    17161 aattgggaat atgtaaataa gagtaagaga gctccaagtg atacaggcac ttgggttaaa
    17221 atcatcaaca agtacatgga cacgatgaag caggcgggtt atcaaaatgt gtatgtctat
    17281 agctatcgta gtttattaca gacgcgttta aaacacccag atattttaaa acatgtaaac
    17341 tgggtagcgg cctatacgaa tgctttagaa tgggaaaacc ctcattattc aggaaaaaaa
    17401 ggttggcaat atacctcttc tgaatacatg aaaggaatcc aagggcgcgt agatgtcagc
    17461 gtttggtatt aagcgatgat ttgaaagagg gatgtgatag tagcaccctc tttttctttg
    17521 ttttatgata gttcatcctc gagtaaattc aagatcttgc tcggaaatga agcttatata
    17581 gtagattgaa tatagacaaa taccttgtga ttggtaaaac attttagaaa ttcatttacc
    17641 tttcctaatc gacttggttt catcttattt caatctatta tagtattggg gaatttcttc
    17701 aaaccacatc agcttggtca gttctacctg cgacctcaaa acttgtgctt tggtcaagct
    17761 gggtttagtt tcctagtttg ctgatggatt tccattgact ataagcatcc aaccctcttt
    17821 ttgtcttcta aagaattctt aaattatcag tctattgcaa cttttctcat ataagttctt
    17881 tgtcttgcta ttggttttcc ttagtagtat actaaggtag taatcattaa gaagtggtta
    17941 caaaaaataa tgaatgaggt aaagaaaatg gtagaattga aaaaagaagc agtaaaagac
    18001 gtaacatcat tgacaaaagc agcgccagta gcattggcaa aaacaaagga agtcttgaac
    18061 caagctgttg ctgatttgta tgtagctcac gttgctttgc accaagtgca ctggtatatg
    18121 catggtcgtg gtttccttgt atggcatcca aaaatggatg agtacatgga agctcttgac
    18181 ggtcaattgg atgaaatcag cgaacgcttg attacactcg gtggaagccc attctctaca
    18241 ttgacagagt tccttcaaaa tagtgaaatc gaagaagaag ctggtgaata ccgtaatgtt
    18301 gaagaaagct tggaacgtgt tcttgttatc taccgttact tgtcagaact tttccaaaaa
    18361 ggtttggatg tcactgatga agaaggtgac gatgtaacaa acggtatctt tgcaggcgct
    18421 aaaactgaaa cagataaaac aatttggatg cttgcagccg aacttggaca agcacctggt
    18481 ttgtaagaaa taaggaaaca tagataaatc tgtaggaaat ttcttacaga ttttttctat
    18541 tttgtaagct attccaaacc agtctttttt tgagtttttt gataaaatag tactatcagt
    18601 gaaaaggatg gaagcatgac taagaaaatc gtagctattt gggcccagga tgaagagggt
    18661 gtgattggta aggaaaatcg tctgccttgg catttgccag cagaattgca gcactttaaa
    18721 gaaacaactc tgaatcatgc tatcttgatg gggcgtgtga cctttgatgg gatggggcgt
    18781 cgcttgcttc caaaacggga aaccttgatt ttgacgcgta atccggaaga aaagatagat
    18841 ggggttgcta cttttcagga cgtccagtct gttcttgact ggtatcaggc tcaagaaaag
    18901 aatctctaca ttatcggtgg gaagcaaatt tttcaggctt ttgaagctta ccttgatgaa
    18961 gtgattgtca ctcacattca tgctcgggtg gaaggagata cctatttccc tgaagaactt
    19021 gacttgtctc tttttgagac agtttcaagc aaattttacg ccaaagatga gaagaatcct
    19081 tatgatttta ccatccaata ccgcaagaga aaggaagtct aatggaacgg agtttatttg
    19141 gtctattcac ggcttttctg tgtttcatct gctttctggc aggagcacaa gcttttcgta
    19201 aaaagcgtta cgggctttct atcctccttt ggttaaatgc ctttaccaat ctggtcaata
    19261 gtattcatgc tttttacatg accttatttt agatagaatg acagtataga atggaaggaa
    19321 atcatgtcta caaatagaaa aaatgatatg atggtttatt gctcattttg tggcaaaaac
    19381 caagaagaag tacaaaaaat aattgctggc aacaatgctt ttatttgtaa tgaatgcgtg
    19441 gagttagctc aggaaatcat tcgagaagaa ttggttgagg aagtcttggc agacttgtct
    19501 gaggtgccaa aaccaattga actcctccat atcttgaacc actatgtaat tggtcaagat
    19561 cgtgccaagc gtgccttggc agtggcggtt tataaccact acaaacgcat caatttccac
    19621 gatacacgcg aagagtcaga agatgtggat ttgcagaagt caaacatttt gatgattggc
    19681 ccaactggtt cagggaaaac tttccttgcc cagaccttgg ctaagagctt gaatgtacct
    19741 tttgctattg cggatgcgac agctctgacg gaggctggtt atgtgggtga ggatgtggaa
    19801 aatatcctcc tcaaactctt gcaggttgct gactttaaca tcgaacgtgc agagcgtggc
    19861 attatctatg tggatgaaat tgacaagatt gccaagaaga gtgagaatgt gtctatcaca
    19921 cgtgatgttt ctggtgaagg ggtgcaacaa gcccttctca agattatcga gggaactgtt
    19981 gctagcgtgc cgcctcaagg tggacgcaaa catccacaac aagagatgat tcaagtggat
    20041 acaaaaaata tcctcttcat cgtgggtggt gcttttgatg gtattgaaga aattgtcaaa
    20101 caacgtatgg gtgaaaaagt catcggattt ggtcaaaaca ataaggcgat tgacgaaaac
    20161 agctcataca tgcaagaaat catcgctgaa gacattcaaa aatttggtat tatccctgag
    20221 ttgattggac gcttgcctgt ttttgcggct cttgagcaat tgactgttga tgacttggtt
    20281 cgcatcttga aagagccaag aaatgccttg gtgaaacaat accaaacctt gctttcttat
    20341 gatgatgttg agttggaatt tgacgacgaa gcccttcaag agattgctaa taaagcaatc
    20401 gaacggaaga caggggcgcg tggacttcgc tccattatcg aagaaaccat gctagatgtt
    20461 atgtttgagg tgccgagtca ggaaaatgtg aaattggttc gcatcactaa agaaactgtc
    20521 gatggaacgg ataaaccgat cctagaaaca gcctagaggt gactatggaa cttaatacac
    20581 acaatgctga aatcttgctc agtgcagcta ataagtccca ttatccgcag gatgaactgc
    20641 cagagattgc cctagcaggg cgttcaaatg ttggtaaatc cagctttatc aacactatgt
    20701 tgaaccgtaa gaatctcgcc cgtacatcag gaaaacctgg taaaacccag ctcctgaact
    20761 tttttaacat tgatgacaag atgcgctttg tggatgtgcc tggttatggc tatgcccgtg
    20821 tttctaaaaa ggaacgtgaa aagtgggggt gcatgattga ggagtactta acgactcggg
    20881 aaaatctccg tgcggttgtc agtctagttg accttcgtca tgacccgtca gcagatgatg
    20941 tgcagatgta cgaatttctc aagtattatg agattccagt catcattgtg gcgaccaagg
    21001 cggacaagat tcctcgtggt aaatggaaca agcatgaatc agcaatcaaa aagaaattaa
    21061 actttgaccc aagtgacgat ttcatcctct tttcatctgt cagcaaggca gggatggatg
    21121 aggcttggga tgcaatctta gaaaaattgt gaggaaaaga aaatggcaaa aacaattcat
    21181 acagataagg ccccaaaggc tatcggaccc tatgttcaag gaaaaatcgt tggcaacctt
    21241 ttgtttgcta gcggtcaagt tcccctatcc cctgaaactg gggaaattgt aggagagaat
    21301 atccaagaac agacagagca agtcttgaaa aacatcggtg ctattttggc agaagcagga
    21361 acagactttg accatgttgt caaaacaact tgcttcttga gcgatatgaa cgactttgtt
    21421 ccttttaatg aggtttacca aacggccttc aaagaggaat tcccagctcg ttcagctgtg
    21481 gaggtagctc gtcttcctcg tgatgtaaaa gtcgaaattg aagtcatcgc agagattgga
    21541 taagctagtt gaagtttggt gttgccaaac ttcttttgat ataaggagaa aaagatgaca
    21601 aagaaacaac ttcacttggt gattgtgaca gggatgagtg gcgcagggaa aactgtagcc
    21661 attcagtcct tcgaggatct aggttatttc accattgata atatgccgcc agctctcttg
    21721 cctaagtttt tgcagctggt tgaaattaag gaagacaatc ctaagttggc cttggtagtg
    21781 gatatgcgta gccgttcttt cttttcagag attcaagctg ttttggatga gttggaaaat
    21841 caagatggtt tggatttcaa aatcctcttt ttggatgcgg ctgataagga attggtcgct
    21901 cgttacaagg aaaccagacg gagtcaccca ctagcagcag acggtcgtat tttagatgga
    21961 atcaagttgg aacgtgaact cttggcacct ttgaaaaata tgagccaaaa tgtggtggat
    22021 acgactgaac tcactccacg tgagctgcgc aaaacccttg cagagcagtt ttcagaccaa
    22081 gaacaagccc agtctttccg tatcgaagtc atgtctttcg gatttaagta tggaatcccg
    22141 attgatgcgg acttggtctt tgatgtccgt ttcttgccaa atccctatta tttaccagaa
    22201 ctgagaaacc aaacgggtgt ggatgaacct gtttatgatt atgtcatgaa ccatcctgag
    22261 tcagaagact tttatcaaca tttattggcc ttgattgagc cgattctgcc aagttaccaa
    22321 aaggaaggta agtccgtttt gaccattgcc atgggatgta cgggtggaca acaccgtagt
    22381 gtggcatttg ctaaacgctt ggtgcaggac ttatccaaga attggtctgt taatgaaggg
    22441 catcgcgaca aagaccgcag aaaggaaacg gtaaaccgtt catgagaaaa ccaaagataa
    22501 cggtgattgg tggagggact ggaattcccg tcattctaaa aagtctgcgg gaaaaagatg
    22561 tggaaatcgc agctatcgtg acggtggcag atgatggtgg ttcttcaggt gaactccgaa
    22621 aaaatatgca acagttgaca ccgccaggtg atcttcgtaa tgtccttgtg gccatgtcgg
    22681 atatgcctaa gttttatgag aaggtctttc agtatcggtt ctctgaggat gccggagcct
    22741 ttgctggcca tccattggga aatctcatca ttgctggctt gtcagaaatg cagggttcaa
    22801 cctataatgc catgcagtta ttgagcaaat ttttccatac aacagggaaa atttatcctt
    22861 ccagtgacca tcctttgacc cttcatgcag tctttcagga tgggacagaa gtggctggag
    22921 agagtcatat tgtagaccat cgaggcataa ttgacaatgt ctatgtgacc aatgccctaa
    22981 acgatgatac gcctctggcc agccgtcgag tagtgcagac catccttgaa agtgacatga
    23041 ttgtcctagg gccaggttcc ctctttacct ctattttgcc caatatcgtg attaaggaaa
    23101 ttgggcgggc tcttttggaa accaaggcag aaattgccta tgtctgcaat atcatgaccc
    23161 aacgtgggga gacggaacac tttacagata gcgaccacgt ggaagtcttg catcgtcacc
    23221 ttggtcgccc ttttatcgac actgtcttgg tgaatattga aaaagtgcct caggaataca
    23281 tgaattccaa ccgttttgat gaatacttgg tgcaagtgga acacgatttt gtaggtcttt
    23341 gtaagcaagt ttcgcgcgtg atttcatcta acttccttcg tctggaaaat ggcggtgcct
    23401 tccacgatgg agatttgatt gtggacgagt tgatgcgcat tatacaggtg aaaaaatgag
    23461 tttcacagta gcagtaaaag aagaaatctt gggccaacac catctgagct ggcatgaatt
    23521 atctgccatt atcaaaatgt ctggtagcat cggtctctcg acttcgggct tgactttgtc
    23581 agttgtgaca gaaaatgcca aactggcccg tcacctctat gagtcctttc tccatttcta
    23641 tgaaatcaaa tctgaaattc gtcaccacca acggagcaat cttcgcaaga atcgcgtcta
    23701 taccgttttt acagatgaaa aggtgcagga tttgttaagt gatttgcact tggcagactc
    23761 tttctttggc ctggaaacag gtattgatga ggcgatttta tcggatgagg aagcaggtcg
    23821 tgcctatctc tgtggcgctt tcttggcaaa tgggagcatt cgtgaccctg agtcaggcaa
    23881 gtaccagttg gaaatcagtt ctgtttatct ggaccacgcg caaggaattg cctcccttct
    23941 ccaacagttt ttactggatg ccaaggtgct tgagcgcaag aagggggctg tgacctatct
    24001 ccagcgagca gaagacatta tggacttctt gatagtaatc ggagccatgc aggcacgtga
    24061 tgattttgag cgggttaaga ttttgcgaga aacccgtaac gacctcaatc gggctaataa
    24121 tgccgagaca gctaatatcg ctcggacagt ttctgccagt atgaagacca ttaacaatat
    24181 cagtaaaatc aaagatatca tgggcttaga aaatttgcca gtagatttgc aggaagtggc
    24241 gcaactgaga attcagcacc cagactactc tatccagcag ttagcagata gtctcagcac
    24301 ccctctgacc aaaagtggtg tcaatcacag actcagaaaa atcaataaga tagcggatga
    24361 attataaaac cacgaatcct atgtgactcg tggttctttt ttataaacta gtagagtgtt
    24421 ttggttgtac tttttgttca gggtcaatgt agttgatagc gttgttgaca gcagttggag
    24481 cttctccgag gcctgtcgca atcagatcaa tttttccgtc atagtagcag cagtcaccga
    24541 tagcatagat acctgcttgg ctggattcct gtttgctgtt gacgataatc ttgtgacggt
    24601 tgaggtcgag cccccagttt ttaaggttac cgacagaaga tttgaaacca tagttgacaa
    24661 agaggtggtc taggtcaatg gtttcagttt catcagattt gacttttgtg atttcaagtt
    24721 tatcaagtgt ttttccattt ccaaggagtt ggctaggggc gaatggtgtc ttgatggtta
    24781 cagatgattc ttgcaaggct tgaacactgt gttccaaggc acggaaatta tctctgcggt
    24841 gaacaagggt agttggtgcg attttttcaa aagccaaagc ccaatccaca gccgagtctc
    24901 ccccaccaag aatcgtcact ttcttaccag cgtattgctg aatgttagaa acgtggtagt
    24961 ggatattttc atagccctca acactttcaa gttccagcgg acgtggtttg aaggcaccgc
    25021 cacccatagc gatgataact gttttagtca ggtgacttcc tttagaagtt gtgatggcaa
    25081 attcttcttc ttgtttgtca atctcaagaa ccgtttcatt gagatgaata ggggtatcaa
    25141 atccatttag ctgttcaatc aagcggttag tcaactcttc tccagtcagg tttgggaagc
    25201 ctggtacgtc taggatttcc ttttcagggt agagaatagc aggttgtcca cctagctggg
    25261 gaagagagtc gatgatttga accttggctt ggcgtaggtg ggcataaaag gctgcaaaaa
    25321 gcccgacagg accaccaccc acaatggtaa tatcatagag ttgagacata gtttctcctt
    25381 tgttttttct agtcagttta ttttatcata tttttgttca atgtaaaatg gactaggata
    25441 gggaaaaaaa taccagaaaa tggtataata ggacgaaagt gttttgatag ggaggatatc
    25501 agggatgaat tttcaacaat tatccaatct gcaatattgg accagtttgt ttgcaagtcc
    25561 atggacgata gctatcaatc tgattgatat tttgattgtt gcttatattt tataccattt
    25621 tacaaaagct attgcaggaa ccaagattat gattttggta cgtggagttt tggtgtttat
    25681 tttagctcaa atccttgcaa atatgattgg tttgactacg atttcttggt taatcaatca
    25741 aattattact tatggggtta ttgcggcggt tgttatcttc tctccagaga ttcggactgg
    25801 tttggaacgt ttgggaagag cgacagattt cttttccaat gcccctatta gtgctgagga
    25861 acagatgatt cgtgcctttg ttaagtctgt tgaatacatg agtcctcgta aaatcggggc
    25921 cttggttgct attcagcgtg tacgtacctt gcaggagtat atttcgacag gaattccctt
    25981 ggatgctaag atttctgcag aacttctcat taacattttt attcccaaca ctcccctaca
    26041 tgatggtgcg gtgattatca aagaagaacg tatcgctgtg acgtctgcct atctgccctt
    26101 gacaaaaaac acagggattt ccaaggaatt tgggaccaga caccgggcgg ctatcggttt
    26161 atcagaagtc tcagatgcct tgacttttgt cgtatcagag gaaacgggag gaatttcgat
    26221 aacctataat ggaaggttta agcacaacct aacacttgat gaatttgaaa cagaattacg
    26281 tgaaatctta cttccaaaag aggaagtggg tcttagtttt aaagaacgat tgctaggagg
    26341 atggaaacat gaaaaaaaat agtttatata tcatatcctc actctttttt gcttgtgtct
    26401 tatttgtcta tgctacggcg acgaattttc aaaacagtac cagtgctagg caggtaaaaa
    26461 cggaaaccta tactaataca gtaacaaatg tccctattga catacgctat aatagtgata
    26521 agtattttat tagcggtttt gcttcagaag tatcagtggt cttgactggt gcaaatcgcc
    26581 tatcgctagc tagtgaaatg caagaaagta cacgtaaatt caaggttact gctgacctaa
    26641 cagatgccgg tgttggaacg attgaagttc ctttgagcat tgaagattta cccaatgggc
    26701 tgaccgctgt ggcgactccg caaaaaatta cagtcaagat tggtaagaag gctcagaagg
    26761 ataaggtaaa gattgtacca gagattgacc ctagtcaaat tgatagtcgg gtacaaattg
    26821 aaaatgtcat ggtgtcagat aaagaagtgt cgattacgag tgaccaagag acattggata
    26881 gaattgataa gattatcgct gtcttgccaa ctagcgaacg cataacaggt aattacagtg
    26941 gttcagtacc tttgcaggca atcgatcgca atggtgttgt cttaccggca gttatcactc
    27001 cgtttgatac aataatgaag gtgactacaa aaccagtagc accaagttca agcacatcaa
    27061 attcaagtac aagcagttca tcggagacat cttcgtcaac gaaagcaact agttcaaaaa
    27121 cgaattaaaa atagaaaagg attttataac aatgggtaaa tattttggga ctgatggagt
    27181 ccgtggagaa gctaacctag agctaacacc agaattagcc tttaaactag gacgttttgg
    27241 aggctatgtt cttagtcaac atgaaacgga agcgccgaaa gtctttgtag gacgtgacac
    27301 acgtatttca ggggaaatgc tggaatcggc cttggtggca ggtctccttt cagtagggat
    27361 tcacgtatac aaacttggtg tccttgcaac accagcagta gcttacttgg ttgaaactga
    27421 aggagcaagt gccggtgtca tgatttctgc tagccacaac ccagcccttg ataacggaat
    27481 caagttcttt ggcggtgatg gcttcaaact agatgatgaa aaagaagcag aaattgaagc
    27541 cttgctagat gctgaggaag acactcttcc tcgtccaagt gcagaaggct taggaatttt
    27601 ggtagattat ccagaaggct tgcgtaagta tgaaggatac cttgtttcaa ctggaactcc
    27661 tcttgatgga atgaaggttg ccttggatac agctaatgga gcagcttcta ccagtgcccg
    27721 tcaaatcttt gcagaccttg gtgcccaatt gacggttatc ggggaaacac cagacggtct
    27781 taacatcaac cttaatgttg gttcaacaca tccagaagcc cttcaagaag tggtcaaaga
    27841 aagtgggtca gctattggtt tggcctttga tggagacagt gaccgcttga ttgctgttga
    27901 tgagaatggt gacatcgtcg atggtgacaa gattatgtac atcatcggaa aatacctttc
    27961 tgaaaaagga caattggctc aaaatacaat tgtgacaact gttatgtcta accttggttt
    28021 ccacaaggcc ttgaatcgcg aaggtattaa caaggcagtt actgcagttg gtgaccgcta
    28081 cgttgttgaa gaaatgagaa aatcaggtta caaccttggt ggtgaacagt ctggtcacgt
    28141 tatcttgatg gattacaata ccacaggtga tggtcaatta tcagcagttc aattgactaa
    28201 aatcatgaag gaaactggta agagcttatc agagttggcg gcagaagtaa cgatttatcc
    28261 acaaaaatta gttaatatcc gagtggaaaa cgtcatgaag gaaaaggcca tggaagtgcc
    28321 agctatcaag gccatcatcg agaagatgga agaagaaatg gcggggaacg gccgtatcct
    28381 tgttcgtcca agtggaacag aacccctctt gcgtgttatg gcagaagcgc ctacaacaga
    28441 agaagtagac tactatgttg ataccatcac agatgtagtt cgtgctgaaa ttgggattga
    28501 ctaaatccta gaaaactaga tgaaaataaa aaattatggt acaatagctt ataatattgt
    28561 agccgatgga gaaagacatg aatcttaaac gtgaacaaga atttgttagt cagtatcatt
    28621 ttgatgcgcg taattttgaa tgggaaaatg aaaatggagc tcctgaaacc aaggtggatg
    28681 tgaatttcca attgctccaa catgaccaag aaaatcaagt gacttccttg attgtcatct
    28741 tgagctttat gattgtattt gataagtttg tcattagtgg aacaatctca caagtaaacc
    28801 atatcgatgg ccgtattgtc aatgaaccaa gtgaattgaa ccaagaagag gtggaaacct
    28861 tggctcgtcc atgtttgaac atgctcaatc gtttgactta cgaagtgact gaaattgcat
    28921 tagacttacc aggaattaat ttggagttct aatatgaaat tagctgtttt cacagattcc
    28981 tctgcttatc tcagtgaaga gaccttgcaa agagaagact tgtttgtctt ggatattcct
    29041 gtcaatattg atggtgagga atatgtcgaa ggcatcaatc tgtctgctga ggaattttac
    29101 caaaaaatgg ctcaggcttc tgaattgcct aagaccagtc aaccaagtat tgccaagtta
    29161 gatgagatct taacttcgct caaagaacaa ggctatacac atgccttggg gcttttccta
    29221 tcttctggaa tttcaggttt ttaccaaaat atccagtata tggtcgatga ctatgagggc
    29281 ttaaccattg ctttcccaga cactttgatt acaagtgctc ccctaggcat catggttgaa
    29341 agcgtcttta attggcgtga tcagggcgat gattttgcca gcattcagga taagctagcc
    29401 attcaaatca gccgtacgtc agcctttatc atggtagatg acttggatca tttggtaaaa
    29461 ggtggacgcc tttcaaatgg ggctgccatt ttgggcaatt tgcttagcat taagccaatc
    29521 ctttatttta acgatcaagg tgtgattgaa gtttacgaaa aagttcgtac tgaaaagaag
    29581 gccaccaagc gcttaattga aattatcaag gaaacaacgg cttcaggtca ataccgggtc
    29641 attgtcattc atgggaatgc tcctgaaaag gctgaagaat tgcgtcagca cttgcttgat
    29701 tttggcttgg gttcggatgt ttcacttgct acatttggta gtgtcattgg aacgcaccta
    29761 ggagcaggaa gtattgctct gggttatatt ccagtgattt agttggcgct tctaggctag
    29821 ttaagatgcc ttgtatctta gaaattgaac acggactacc tgcctcttga aaaaagatgc
    29881 ctgtcttgcc tttcgtggaa agtcagtgcc attccctatt tttcagaggc agctaaggtc
    29941 ctttgtatct tgataattga acacgcctgg aaccctgtgt gaaaaagata gttcttccaa
    30001 gaagtagaca cttcttgatt ggaattccta ttttcacttt gtgttcttac ggactttgta
    30061 tcttagacag gagtagagat gagtattcga gtaattattg ccggttttaa gggaaagatg
    30121 ggccaggctg cttgtcagat ggtattgact gatccagact tggacttggt ggcagttttg
    30181 gatccttttg agtctgagtc agaatggcag gatattcctg ttttcaagga taaggctgat
    30241 ttagctggtt ttgaagcgga tgtctgggta gattttacta ctccagctgt tgcctacgaa
    30301 aatacacgtt ttgctcttga aaatggcttt gctccagtag ttggaacgac tggtttcacg
    30361 agtgaagaaa ttgcagagct aaaagaattt tctcgtgccc aagacttggg tggcctgatt
    30421 gcccctaact ttgccttggg tgctgtctta ctcatgcaat ttgcgacgca ggctgccaaa
    30481 tatttcccaa atgtggagat tattgagctc catcatgaca agaaaaagga tgctccgagt
    30541 ggaacagcca ttaaaacagc tgagttgatg gcagaggttc gagagtccat tcagcaaggc
    30601 gcagcagatg aggaagagct gattgctggt gctcgtggtg ctgactttga tggtatgcgc
    30661 atccactcag ttcgtttgcc aggtttggta gcccatcagg aagtcatctt tggcaatcag
    30721 ggagaagggt tgaccctccg tcatgactcc tatgatcgca tctccttcat gacaggagtc
    30781 aatttgggaa ttaaagaagt tgtcaagcgt catgagcttg tctatggatt agaacactta
    30841 ttatgagatt aacgcaaatg ccttctgaat ttcagaaggc tttaccagta ttagaaaaaa
    30901 ttaaagaagc aggctttgag gcttattttg ttgggggctc tgttcgagat gcccttctcc
    30961 ataaccctat ccacgatgtg gatattgcga cgtcttctta tccagaagag accaagcaga
    31021 tttttccgcg aacagccgat atcggaatcg agcatggaac cgtcttggtc ttagatgggg
    31081 atgaggagta tgaggtaaca acctttcgga cagaggatgt ctatgtggac tatcgcagac
    31141 ccagtgcggt ttcctttgtg cgctcgctag aagaagacct caaacgccgt gatttcacag
    31201 tcaacgcctt tgccttggat gagacaggag aaatcgttga cttgttccat ggtttagaag
    31261 atttggaaaa gcaagtcttg cgagcagttg gagtggctag tgagcgtttc aacgaagatg
    31321 ctttacggat tatgcgtggt ttccgttttc aggctagtct tggttttgca cttgaaccag
    31381 aaacatttaa agctatgaag accttgacgc cgcttttgga gaacatttct gtagagcgta
    31441 ccttcgtcga gtttgataaa ctcttgctgg ctccattttg gagaaggggc ttggcttcca
    31501 tgattgagag tcaagcttat gactatctcc ctgatatggc atctagccag gacaagctca
    31561 acagactgtt tgatttggag actgatttta cttttgaatc ctctgaacaa gcctgggcgg
    31621 ctttactatg ggctttggag attgaaaatg cgcagtcatt tttgaaatct tggaagacct
    31681 cacgccagtt tgccaagcaa gttcaggatt tgctgattat tttggctctg cgtgaaaatg
    31741 gagaattgag caagcgagat tgttatcgct ttgacataga tttgctttta caggctgaaa
    31801 atcttcgtca agctcaagga aaagaagtca acccacaagc catcacagaa aaataccaaa
    31861 gcttgactat ccatgacaag aaagagattc agattaatgg cggtattttg atcaaggaat
    31921 atggctatca gccaggccca gacttgggag agattttaac agagattgag tttgccattg
    31981 tcgatggaga attggagaat aatcgtgaag ccatccatgc ttacctgagg gagaaaaaat
    32041 gagtgatttt atcgttgaaa aactaagtaa atccgttggt gacaagaccg tttttaggga
    32101 tatttccttt attatccatg acttagacag aattggttta atcggtgtca atgggactgg
    32161 caagaccacc cttttggacg tcctttctgg tgtttctgga tttgatgggg atgtcagtcc
    32221 tttttcagct aaaaatgatt accagattgg ttacttgact caggatcctg attttgatga
    32281 tagaaagaca gttttggata cggttctatc tagtgaactc aaggaaatcc agctcattcg
    32341 tgagtatgaa ttgattatgc tcgactatag tgaggacaag caggcgcgtt tggaacgtgt
    32401 catggcagag atggactctc tccaagcttg ggaaatcgaa agtcaggtca agaccgttct
    32461 tagcaaattg ggcattcaag acttatctac tcctgttggg gaattgtcag gtggtctgag
    32521 aagacgggta cagttggcac aagtcttact tggcaaccac gacctcttgc ttttggatga
    32581 gccgaccaac catctggata ttgcgattat tgagtggctg accctctttt tgaaaaattc
    32641 taagaagacc gtccttttta tcactcacga tcgttatttc ttagacgctt tgtcaacacg
    32701 gattttcgag ttggatcgtg caggcttgac cgagtaccag ggcaattacc aggactatgt
    32761 tcgcctaaag gcggaacagg atgagcgcga cgcggctctt cttcacaaaa aagaacaact
    32821 ctacaaacaa gaattggcct ggatgcgcag acaaccgcag gcgcgtgcga ccaagcagca
    32881 ggcccgtatc aatcgattcc atgatctgaa aaaggaagtt tcaggcagta gtgctgagac
    32941 agacttgacc atgaactttg aaaccagtcg gattgggaag aaagtcatcg agtttcaggc
    33001 tgtttccttt gcctatgaaa acaagcctat tttgcaagat tttaatctct tggtgcaggc
    33061 caaagaccgt atcggaatcg ttggggacaa tggtgttgga aaatcaaccc tgctcaactt
    33121 gattgcagga agtcttgagc caactaaagg acaagttgtg attggggaaa ctgttcgcat
    33181 cgcctatttc tctcagcaaa ttgagggttt ggatgaaagc aagagagtta tcaattacct
    33241 gcaggaagtg gcagaggagg tcaagaccag tggtggttct acgacttcca tcgctgagtt
    33301 gctggagcaa ttcctcttcc cacgttcgac gcatggaacc ttgattgaga aattgtcagg
    33361 gggtgagaaa aaacgtcttt atctcctcaa actgcttttg gaaaaaccaa atgttcttct
    33421 tttagacgag ccaaccaatg acctagatat tgcaactttg acagtcttag agaatttctt
    33481 gcaaggtttt gcaggtcccg ttttaacagt cagtcacgac cgctatttct tggataaggt
    33541 agcgaccaag attctcgctt ttgaggatgg caagattcgt cctttctttg gtcattacac
    33601 cgactatctt gatgaaaaag cttttgaaac agatatggcc aatcaagtgc aaaaggccga
    33661 aaaggaaaaa gtggtcaagg ttcgagaaga caagaaacgc atgacctacc aagaaaagca
    33721 ggagtgggca agtattgaag gtgatattga aaccttggaa aaacgtatcg ctgctattga
    33781 agaggaaatg caggctaacg gctctgactt tggtaagctg gctactctcc aaaaagaatt
    33841 ggatgagaaa aatgaagcac tccttgaaaa atacgaacgc tatgagtatc tcagtgaatt
    33901 tgatagttaa gactattcga aaatcaaagt gcaaactatg tcggcttcac attgccgact
    33961 caagtacagc ctgtgaccgg cttcctaatt tgcactttga tttttattga gtataaaaga
    34021 atagaaaaat cccgtctcat gaaaggattt ctctattctt ttttggtttc ttgatgaaag
    34081 atattttgcc aggtttcgtg gcgacgccag atactggtat ggatgatacc atctaactca
    34141 tagcagatga gtttggtttt ttgactgatg gaagtaattt gaatgtcctt gatagcagaa
    34201 tttaactctt ttttggtctt ataagcctct ttatccatct gctctccatc ttggcgaata
    34261 tagacaaaat catcagtcaa gagttcttct agttggtttc cttggtcaat caattgttca
    34321 cgcataagca attttttata gacattgtct aaaatttcat cctcagggat aggtgctggt
    34381 tcgatatgga catcggtatc aaagacgcca aaacgctcct ccagcataga ctcgacctga
    34441 tccgcgattt catggctttc aaaaacagac aagtcaggat tcatctctag tgtaatatcc
    34501 aggtagatgt tgctaccgta ggtgcgacct ctttgcgatt tgaccttgct gattttggga
    34561 atttccatga tagccttttg gtagtcctcg agcaggcggt cgtcaaagcc atctgaaaga
    34621 ctaaaggaag actcgatgaa gatatcatag gcagtcttca agataaagaa agtgatgata
    34681 atagcaacca gtttatccac aatcggataa ttaaaactac tagctaggat ggcaatggcg
    34741 gttccaagtg aggtaacagc gtcagaaaga ttgtccttag cagctgtctt cagcgccttg
    34801 gagttggatt tcttactgag gcgagtattg tagagataga ccacaaacat aatcgctgca
    34861 gaaatgattc ctagagttgc accaagagga tcaatgaccg tttcttcccg actgagaatc
    34921 ttttgaatgg tatctcttag aacatcgaaa ccgacataga acatgatgat agaagtgatc
    34981 aagcttgcca aatcttcaat cttccaatga ccaaaacggt ggtcacggtc tgcaggctgg
    35041 cgcgccatcc gaatcccgat taagagggcc acatttccaa tgatgtccga tacgttatta
    35101 aaaccatcgg ccaccaaact ggatgaatga aggagatgac cagttgctaa tttggctgca
    35161 gacaagatca aataggtcga aatactgata atggctccac gctcggctaa cttgagattt
    35221 gagatagatt gcttcattca acttcctttc tagtcacata gcattctacc attatactgg
    35281 ttttcaagga aaaattcaaa taaggcagtt tttattcttt gaaaactccc caaaatttgg
    35341 tataatggta ctactcaagg gagtagctgg cagaaacctg tgatagtgtc gtcattccga
    35401 attttatgct gaaaagtatg ctttccggcc ctatcttaaa cagcgagact tgttatgatt
    35461 aacaggtctc tttttgtttg tcgtgaaaag atatgacaga aagagagtct gttttgcaca
    35521 caatgtcaag gaggagacac atgtcaaaag aacaaaaacg ccaagcgttt tatactcaga
    35581 gccctgaaga ggtcttgcag gctgtggatg cgaccgagca aggtttgtca tcaagtgagg
    35641 cggaaaagcg ccttgccgaa tttgggcaca atgaactcga agaaggcgag aaacgatcaa
    35701 tcttggtcaa attcatcgag caatttaagg atttgatgat tatcatccta gttgcggcag
    35761 caatcttgtc agtcgtgact tctggtgggg aagatatcgc agatgccatt atcatcctag
    35821 ctgtggttat catcaacgct gcctttggtg tttaccaaga aggaaaagct gaagaagcta
    35881 ttgaagccct caaatccatg tctagtccag ttgcccgcgt tcttcgtgat ggacacatgg
    35941 cagagattga ctctaaagaa ttggtaccag gcgatatcgt tgcccttgaa gcaggtgacg
    36001 tggtaccagc ggacctacgt ttgatagaag ccaactctct taaaattgaa gaagcagcct
    36061 tgacaggtga atctgtacca gtcgaaaaag acttgtcagt cgagcttgcg acagatgctg
    36121 gtattggtga ccgtgtcaac atggccttcc aaaactcaaa cgtaacctat ggtcgtggga
    36181 tgggtgttgt tgtcaataca ggtatgtata ctgaagttgg tcatattgct ggtatgcttc
    36241 aagatgcgga tgagactgat acaccactca aacaaaactt gaacaacctt tctaaggtct
    36301 tgacctatgc tatcttggtc attgcccttg ttacttttgt agtgggtgtc ttcattcaag
    36361 ggaaaaatcc acttggtgag ttgttgactt ctgttgccct tgccgttgca gccattccag
    36421 aaggacttcc tgctatcgtt accatcgttc tttctcttgg tactcaagtt ttggccaaac
    36481 gacattccat cgttcgtaag ttgccagcag ttgaaacact tggttcaact gaaatcatcg
    36541 cttctgataa gactggtacg ctgactatga acaagatgac agtcgaaaaa gtcttctacg
    36601 atgcggttct acatgactca gctgatgata ttgaactagg tcttgaaatg ccactacttc
    36661 gttcagttgt cttggccaat gatacgaaaa tcgatgtgga aggtaacttg attggtgacc
    36721 caaccgaaac agcctttatc caatatgcct tggacaaggg ctatgatgtc aaaggtttct
    36781 tagagaaata tcctcgtgta gctgaattgc catttgactc tgaccgtaag ctcatgtcaa
    36841 cagttcaccc attgccagat ggtcgtttcc ttgtagcagt caagggtgcg ccagaccaac
    36901 tcttaaaacg ttgtcttctt cgtgataagg ctggggatat tgctccgatt gatgagaagg
    36961 ttacaaatct cattcataca aacaattctg aaatggctca tcaagccttg cgtgtccttg
    37021 caggtgctta taagattatc gatagtattc cagaaaatct cacttctgaa gagcttgaaa
    37081 atgatttaat ttttactggt ttgattggga tgattgaccc tgaacgtcct gaagccgctg
    37141 aggctgttcg tgtggctaag gaagcgggaa tccgtccaat tatgattaca ggtgaccacc
    37201 aagacacagc ggaagccatt gccaaacgtt tgggaatcat tgacgcaaac gatacagaag
    37261 gtcacgtttt aactggtgct gaactcaatg aactgtcaga tgaagaattt gaaaaagtcg
    37321 ttggtcaata ctctgtttat gcccgtgtgt ctccagaaca caaggttcgt atcgtcaagg
    37381 cttggcaaaa acaaggtaag gtcgttgcca tgacaggtga cggtgtcaat gatgccccag
    37441 ctctgaaaac agcagacatc ggtatcggta tgggaatcac tggtacagag gtttctaagg
    37501 gggcttctga tatgattctt gcagatgata actttgcgac tattatcgtc gcagtggaag
    37561 aaggacgtaa ggtcttctca aatattcaaa agactattca gtacctactt tctgccaata
    37621 ctgctgaagt attaaccatc ttcctatcaa ccttgtttgg ttgggacgtc ttgcagccag
    37681 ttcatctttt gtggattaac ttggtaacgg ataccttccc agcaattgca ctaggtgttg
    37741 aacctgcgga acctggtgtc atgaatcata aaccacgtgg acgcaaggca agcttcttct
    37801 caggtggtgt tttgagttct atcatttatc aaggtgtact ccaagcagct cttgttatga
    37861 gtgtttatgg ccttgcgatt gcttacccag ttcatgtggg tgacaatcat gctattcatg
    37921 cagatgccct aacgatggcc tttgcaaccc ttggtttgat tcagctcttc catgcctaca
    37981 atgtcaagtc tgtctaccaa tccatcttga cagttggccc attcaagtct aagaccttta
    38041 actggtccat cttggtatcc tttatccttc tcatggcaac aatcgttgta gaaccgcttg
    38101 aaggaatctt ccacgtaacc aaactagact tgtcacaatg gggaattgtt atggctggaa
    38161 gcttctcaat gattatcatc gtcgaaatcg ttaagtttat tcaacgcaaa ctcggttttg
    38221 acaagaatgc gatttaaggg aggtttcgga tgtcagcata tcaattaccg accgtatggc
    38281 aggatgaagc tagtaatcaa ggagctttta cggggttaaa cagaccaaca gcaggtgccc
    38341 gtttcgaaca aaacttgcca aaaggagaac aagcttttca gctttattca ctgggaacac
    38401 caaatggtgt gaaggttact atcttattgg aagaattact agaagctggt tttaaggaag
    38461 cggcttacga cttgtataag attgctatca tggatgggga tcaattcggc tcagactttg
    38521 tgaagctcaa tccaaattcc aagattccag ccttattgga ccagtcaggt actgaaaacg
    38581 taagagtctt tgagtctgct catattcttc tttaccttgc tgagaaattt ggagcctttt
    38641 taccaagtaa tcctgtggaa aaggtagaag ttttgaattg gctattctgg caagcaggtg
    38701 cagcaccttt tctaggtggg ggatttggac atttcttcaa ttatgctcct gaaaaattgg
    38761 aatatcctat taaccgtttt acgatggaag tgaaacgcca gttggattta ttggataagg
    38821 aattggctca gaaaccttat attgcaggca atgactatac gattgcagat attgctatct
    38881 ggtcttggta tggacagtta gttcaaggaa atctttacca aggttctgca aaatttttgg
    38941 atgcctcaag ttatcaaaat ctagtaaaat gggcagaaaa aattgccaat cgtccagctg
    39001 ttaagcgtgg attggaagta acttatacag aaattaaata gcaaaaaagt catcttcgga
    39061 tggctttttg ctacagttga gggaaagggt ttgcagttat cggcttttgt gctataattg
    39121 ctataatata gtaaaaagca agaggagtgt gaggaagtgg aaaagaaaat tgtgaaggat
    39181 atcttatttt tatctcaagt gtctcagccg gcaagtcagg aggaccttta tcttgccaga
    39241 gatttgcagg atacactctt agcaaatcgt gatacctgtg ttggtctagc tgccaatatg
    39301 attggggtgc agaagcgcgt gattatcttt aatcttggct tggttcccgt ggtcatgttt
    39361 aacccagtgc ttctgtcctt tgaaggatct tatgaggcag aagaaggctg tttgtccttg
    39421 gtaggtgtga gatcaactaa gcgttatgaa accataaggc ttgcctatcg tgacagcaag
    39481 tggcaggaac agaccattac cttgacaggc ttcccagctc agatttgcca gcatgagctg
    39541 gatcacttgg aaggacgaat catttaggag gaaagcaaat gaaacgaata gtctttgaac
    39601 ttatttttat cgcaacgacc tggtatatct ttttaccgcc ccttaacctg accagctggg
    39661 aatttctctt cttcctctgt gggcatttgt tagttgtggc aatcttattt ggctttggca
    39721 aggggataaa ccttgtcaaa acggttcatg tgcgccacgg taaggcggaa gctgccttaa
    39781 atcttgaggg tttcaaaatc aatcggttag ggaaaattct gttagcttcg attggaggaa
    39841 ttcttctctt ggcagctttg gtttccttgg taacttccag catgtttcag gctaaaaatt
    39901 atgccaatgt agtcacggtt acggaaaaag actttactga atttcctagg agtgacacca
    39961 gtaaggttcc tatcctagat agaagtactg ctgaaaaaat tggagaccgc tacttgggtt
    40021 ccctaaccga taaggtgtcg caatacgtag cggcagatac ctatacccaa ttgacaattg
    40081 atgggaaacc ttatcgggtc acaccactag aatatgcaga ccctatcaaa tggtttaaca
    40141 atcaagccaa gggaatcggt gagtatatca aggtggacat ggtaactgga aatgcggatt
    40201 tggtggactt gaagacacca atcaagtatt cagactcgga gtattttaac cgtgatgtca
    40261 aacgtcacct gcgcttgaag tacccgacta aaatctttaa aactccatct tttgaggtgg
    40321 acgatgaggg caatcctttc tatgtagcaa cggtttacca aaagcaattt ggacttgcgg
    40381 ttcctcgtcc tgcttcagtc attatcttgg atgctacaaa tggagaaacc aaggaataca
    40441 gcttatcaga tgttccagaa tgggtggaca gggtctatcc agcagaggaa accattgagc
    40501 aaatcaacta caacggcaag tacaaggacg gtttcttgaa tgccatgatt tccaagaaaa
    40561 atgtgaccca gactaccaag ggctataatt acttgtctat cggtaatgac atctatctct
    40621 acacaggtgt gacgtcggct aatgcggatg agagtaatct tggtttcatc cttgaaaata
    40681 tgcgaacagg agaaatcact aagtatagct tggcttctgc gacagaagaa tcagcccgtg
    40741 aatcagcaga aggtgctgtt caggagaaat cctacaaagc aaccttccca atcctcatca
    40801 acctcaatga caagcctctc tacatcatgg gcttaaagga caatgctggc ttggtcaaag
    40861 agtacgccct ggtagacgca gtcgagtacc aaaatgttat cgttgctact acagtggaag
    40921 agatgctcag caagtatgcc aataaaaacg accttgaaat tgacaatgca acgacagaaa
    40981 gcatcaaggg agtagtagca gacctcaaat cagctgttat caagggagac actgtctact
    41041 tctttaaagt tgatggcaag atatacaagg tcaaggcttc agtatccgat gaccttcctt
    41101 accttgaaaa tggtaaaacc ttcgaaggtc aagtaggaaa agacaattat ctcaagacct
    41161 ttaaagtaca ataatactct tcgaaaatct ctagctctat ctgcaacctc aaaacagtgt
    41221 tttgagcagc ctgcggctag tttcctagtt tgctctttga ttttcattga gtataaaaaa
    41281 ggtttattta ataaatatat gttataataa ggtaaattaa gcctaatgga ggacaaagaa
    41341 atgggttttt atttgatggt tgcttcaatg ctactcggac tgctcgcttt gaagataggt
    41401 ttttctcagt tcaaggagaa aaaagataaa ttcttatcta tcttaacaag tttagctggc
    41461 acagcccttg ttctcgtggc tgtctggtta ggatggccca aataaataga aaaacctcgg
    41521 tcaaaccgag gtttttcaaa tgaatttctt ggttgtggct aaaaaatatg ctacactatc
    41581 aatatgaaaa ttttaatccc aacagcaaaa gaaatgaaca cagacttgcc aagtatcgag
    41641 gcaattcctt taaaaccaga aagtcagacc gtgcttgatg ccttggctct ctattctgcc
    41701 agtcaattgg agagtttcta caaggtatcg gctgagaaag cggcggaaga atttcaaaat
    41761 atccaagctt tgaaaaggca aactgctcaa cactatccag ccttgaaact ttttgatggg
    41821 cttatgtacc gcaacattaa gagagataag ctgaccgagg cggaacaaga ttatcttgaa
    41881 aatcatgtct tcattacctc ggctttgtac ggtgttgttc cagccttgtc acccatggct
    41941 cctcaccgtt tggatttttt gatgaaatta aaagtcgctg gtaagacttt gaagagccat
    42001 tggaaggcag tctatgatga agctctgaag aaggaagaag tgattttctc tctcttgtca
    42061 tcagagtttg agactgtatt ttctaaggaa atcagagcaa agatggtgac cttcaaattc
    42121 atggaggata gaggcggtca gctgaagatt cactcaacta tctccaagaa agcgcgcggg
    42181 gcctttctaa cagctttaat agaaaatcaa gtacaaactg tgggggaagc acgtcgcttg
    42241 aactttgctg gatttgttta ccgagaagat ttgtcacaac cacagggatt ggtttttgta
    42301 aaggaagtat agaaatcaga tattttgtat ttggcaatat gtatcatcag ctgttttagt
    42361 ttataaatga gaaaaaaagc gaacaagcta gtcttctgag tgtcagaaaa gtagtcttgt
    42421 tcgcttttat tatgttatac tcttcgaaaa tctcttcaag ccacgtcagc gtcgccttac
    42481 cgtatatatg tcactgactt cgtcagttct atctacaacc tcaaagcagt gctttgagca
    42541 gcttgcggct agcttcctag tttgcttttt gatttttatt gagtgttagt tacttgatag
    42601 cttcgaccaa gtcttgagct tgtttttcaa gtgagtttag gactgtttct tcaagaacca
    42661 attttccgtc tgcccaggca gagtcattaa cacgtgcagc agtgaaatca ccaacgcctt
    42721 gtgtacggat aaatggcaag aggtctttgt agatagcgaa aagttgatcg tgccctgcat
    42781 tggctacaga tgatactgtg acaaacttgt cttgaagggc agaaacgcca cgtgtatcag
    42841 acaagtcaag ggcacgagat agccagtcaa gcaagttttt cactgtacca gggatagaga
    42901 agttgtagac tggagagaaa atccagatag catccgcaac gagaactgct tcacgagcag
    42961 cagctacagc tggatatgtt ggaacttcca aatcttggct gaagagagga agggctgaat
    43021 aatcaaggta gctaacttcc gctttaccag caagagcttt ctcagcttcg agcgccattt
    43081 ggtggttgaa agaaccttga cgtagtgatc cgacgataaa taatactttt ttagacatga
    43141 tgtgtctcct ttttcttaaa atttcgagaa ctctctcgtt gttataaaat atattacaac
    43201 aaaacaaaag aacttgcaag aaatttgctc agagtttatt tgaaaattgt aaaatttcgg
    43261 aaactctagt catttgtgac tgaaaaagta agaactgttt cactttcaaa atcggttttg
    43321 tttgaaggga gaaatagaat tggttgctca aagcacagct ttgaggttgc agataaagct
    43381 gacgtggttt gaagagattt tcgaagagta ttcttatatt cacttgtaat aaagcttaat
    43441 agatggtaaa atagacgagt gaaaaaaaga caaaacaaag caaaaaataa tctactgtgg
    43501 cagtatggtc tagggatgac gattttgttt gtggttatca gtgcttcctt tctgtatatg
    43561 gtttctctta gcatgaaacc ctatcaaaca gctaaaagtg aaggagaaaa attagctcag
    43621 cagtatgcag gattagagaa ggctgatcag gttgatttat acaatggctt ggaatcttat
    43681 tacagcgttc ttggtcgtaa taaacagcaa gaagcgcttg ctgtcctgat tggtaaagat
    43741 gaccataaga tttacgttta tcagctaaat cagggtattt cacaagaaaa agcagaaacg
    43801 gtttctaagg aaaagggagc tggcgagatt gacaagataa cctttggtcg ttatcaagac
    43861 aagccaatct gggaagttaa gtcaggatct gatttttatc tagtagattt tgaaacagga
    43921 gcattggtca ataaggaggg cctatgaaac tatccaaccg tgttttagaa atggaagaaa
    43981 gtgtgacttt ggctgctgga gcccgtgcca aagcactgaa ggctgagggt agagatattt
    44041 tgtctctaac cttgggtgag ccagatttca ctactcccaa aaatatccaa gatgccgcca
    44101 ttgcatcgat tcgagatggg cgtgcttctt tttatacagt aacctcaggt ctgccagagc
    44161 ttaaggcggt ggtcaatagc tactttgagc gcttttacgg ctattctgta gcgtcaaatc
    44221 aagtgacagt cgctgcggga gccaaatatt ctctctatac cttctttatg gctgtggtca
    44281 atccaggtga tgaagtcatc atcccaaccc catactgggt tagctatgga gatcaggtca
    44341 agatggcaga aggcgttccc gtctttgttt ctgctaagga agacaatcac tttaaggtga
    44401 ccgtagagca gttagaagca gctcgcactg acaagaccaa ggttttggtg ctgaattcgc
    44461 catctaatcc cacaggtatg atttacaccc gtgaggaact cttggcaatt ggaaactggg
    44521 ctgtagaaaa tgatattctc atcctagcag atgatatcta tggccgcttg gtttataatg
    44581 gtcatgagtt cacaccgatt tctagcctat cggaagcgat tcgcaagcaa acagtggtca
    44641 tcaatggtgt gtctaaaacc tatgccatga ctggttggcg gattggttat gccgttggag
    44701 aagcagacat tatcgctgcc atgtccaaga ttgcaggtca aacaacttcg aatccgtcag
    44761 cagtagccca atatgcagca gttgaggctc tatcaggtga gcaagatact gtagaaagca
    44821 tgcgtcaggc ctttgaggaa cgtcttaata ccatctatcc cctccttgca gaggtgccag
    44881 gatttgaagt ggtcaaacca caaggggcct tctatctctt cccaaatgtc aaaaaggcca
    44941 tggagatgaa aggttacacg gatgtgacag actttacaac tgctatctta gaagaagccg
    45001 aagtggcctt ggtaacagga gctggatttg gagcatcaga aaatgtccgc ctcagctatg
    45061 cgacagacct agacacgctt aaagaagcag tcgaacgctt gaaagcattt atgggtagtg
    45121 agaatgattg atcattttga gattaaggta aaggatttac aaatttcaga aggattttat
    45181 aggagttttc tcgctccttt ggactataaa atgactttta agacaagttc tctaattagt
    45241 tttctatccc cgaacagccc tcatcctggt ggtgattttt ggctgactca gggaacacaa
    45301 gatcctgttc attttgcttt tttagcagaa aataaggaag aagttcaggc ttgttatgag
    45361 gctggcttag aggcaggtgg gcgagacaat ggggctcctg gttatcgaag tgagcatccg
    45421 atttactatg ctgcttttat gattgacctg gatgggaaca atatagaggt ggtttgccat
    45481 aaagaataaa aaagaaaagg aaaaataatg acaaaacgtg taacgattat tgacgtaaaa
    45541 gactatgttg gtcaggaagt gacgattggc gcttgggttg ccaacaaatc aggaaaagga
    45601 aaaatcgctt tcttacaatt gcgtgatgga acagccttct ttcaaggtgt ggcttttaaa
    45661 ccaaactttg tcgaaaaatt tggtgaagaa gtgggacttg agaagtttga tgttatcaaa
    45721 cgtttgagcc aagaaacgtc tgtttatgtg acaggtattg tcaaagagga cgaacgttct
    45781 aaatttggct atgagttgga catcacagac atcgaagtga tcggtgaatc tcaagactac
    45841 ccaatcacac caaaagaaca cggaacagac tttttgatgg ataaccgtca cttgtggcta
    45901 cgctctcgta agcaagtagc tgtgttgcaa atccgtaacg ctattatata tgcaacttat
    45961 gagttctttg acaagaacgg ttttatgaag tttgacagcc caattctttc aggaaatgcg
    46021 gcagaagatt ctacagaact ctttgaaact gactacttcg gaacgccagc ctacttgagc
    46081 caatcaggtc agctttacct agaagcaggg gctatggctc ttggtcgtgt ctttgacttt
    46141 ggtccagttt tccgtgctga aaaatcaaaa acacgccgtc acttgactga gttctggatg
    46201 atggatgctg agtactcata cttgacacat gatgagtcgc ttgacttgca agaagcttat
    46261 gtgaaagctc ttctacaagg tgttcttgac cgcgcgcctc aagccttgga aaccttggaa
    46321 cgtgatacag aactcttgaa acgctacatt gcagagccat tcaaacgtat cacttatgat
    46381 caagccattg acctcttgca agagcatgaa aatgatgaag atgctgacta cgagcatctt
    46441 gagcatggtg atgactttgg gtcaccacac gaaacttgga tttcaaacca ctttggtgtg
    46501 ccaacatttg tcatgaacta tccagcagcc atcaaggcct tctacatgaa accagttcct
    46561 ggaaatccag agcgcgtgct ttgtgcagac ttgcttgctc cagaaggcta tggagaaatt
    46621 atcggtgggt ctatgcgtga ggaagattac gatgcccttg tcgctaagat ggatgaactt
    46681 ggcatggatc gtacagaata tgaattctac cttgaccttc gtaaatacgg tacagttcca
    46741 cacggaggat ttggtatcgg tatcgaacgt atggtaacct tcgcagcagg aacaaaacat
    46801 atccgtgaag ctattccatt cccacgtatg ttgcaccgta tcaaaccata agaacaggaa
    46861 aacgcccatg tggcgttttt tcgaattcta gtgtttttac ttgcgtaaaa aaattttttc
    46921 tagtataata gtttattgtg agcgaacctc acttacccct tgcaaagtct tggggtcatt
    46981 agaccaaaag gaggaacata tcaatggcta aatacgaaat tctttatatc attcgtccaa
    47041 acattgaaga agaagctaaa aacgctttgg tagcacgttt tgactctatt ttgactgaca
    47101 acggtgcaac tgttgttgaa tcaaaaactt gggaaaaacg tcgtcttgca tacgaaatcc
    47161 aagatttccg tgaaggactt taccacatcg ttaacgttga agcaaatgac gatgcagctc
    47221 ttaaagagtt tgaccgtctt tcaaaaatca acgctgacat tcttcgtcac atgatcgtca
    47281 aaattgacgc gtaagaaggt aaactatgat taacaatgtt gtacttgtag ggcgtatgac
    47341 acgtgacgct gagttgcgtt ataccccatc aaatgtagca gttgcgactt ttactcttgc
    47401 agtaaaccgt acatttaaga gtcaaaatgg tgaacgtgag gctgatttta tcaatgtcgt
    47461 tatgtggcgc caacaggctg aaaatcttgc taactgggct aaaaaaggct cacttatcgg
    47521 ggtgacaggt cgtatccaga ctcgtagtta cgataaccag caaggacaac gtgtctacgt
    47581 gacagaggtc gtggctgaga atttccaaat gttggaaagc cgtagtgtgc gtgagggtca
    47641 cacaggtgga gcttactctg caccaactgc aaactattca gcacctacaa attcagtacc
    47701 agacttttca cgtaatgaaa atccatttgg agcaacaaac ccattggata tttcagatga
    47761 tgatttacca ttctaatgga caactaaact tataaaggag aaaaaacatg gctcaacaac
    47821 gtcgtggcgg attcaaacgc cgtaaaaaag ttgattacat cgcagcaaac aaaattgaat
    47881 atgttgatta caaagatact gagcttctta gccgtttcgt ttcagaacgt gggaaaatcc
    47941 ttcctcgtcg tgtaacagga acttcagcta aaaaccaacg taaagtaaca acagctatca
    48001 aacgcgctcg cgtaatggct ttgatgcctt tcgtaaacga agattaaaga aaagacccgg
    48061 ttgggtctct ttttcatgag cttgaaaaca agaaagcgaa ttaagacccc aacgggtctt
    48121 ttttcacaag ctttgaaatg agagagcgag ttaggctcag tggctccctt tttacgagtt
    48181 tgaaaacaag agaacacatt aaaagcacga tggagctttt tcataaatat gtctcttttc
    48241 tcatccaaga aattaaaata aaaatgataa actttttgaa aataggggat ttgcctactt
    48301 tatgatataa tggaaagagt tagattgaaa gaggtagtga gatggacgcg aaattaagat
    48361 acaaggcaaa gaagatcaag attgtctttt ttgatattga tgatacattg cggaattcaa
    48421 agacagggtt tattccaact acaattccca ctgtttttaa acagttgcgt gaaaaaggaa
    48481 ttttaacagg aatcgcctct ggacgtggca tttttggtgt tgttccagag attcgtgatc
    48541 tcaagcctga cttttttgta actttgaatg gggcttatat cgaagataaa aaaggtcagg
    48601 tcatttatca gcatcagatt gaaaagtcat atgttgagga gtatatctct tgggctaagc
    48661 aagaaggaat tgagtatggc ttggttggga gtcatgatgc caagttgtcg actcgcaccg
    48721 atatgatgag tgaagctatc aatccaattt atcccgactt agatgtagat cccgatttcc
    48781 atgaaaaaga agatatctat cagatgtgga cttttgaaga taagggagat gacttgcact
    48841 tgcctgacag tctctcagac aaacttcgca tggttcgttg gcatcaacat tcgtctgata
    48901 ttgtgccgat ttcaggctcc aaagcgacgg gggtggaaaa ggttgtggaa caccttggct
    48961 tgaaaccaga gaaggtcatg gtttttggag atggtctcaa tgacttggaa ctctttgatt
    49021 atgctggaat cagcgttgcc atgggaattt ctcatgataa aatcaaagaa aaagcagatt
    49081 atattacaaa aacattagaa gaagatggca tttttgatgc cttagaagta tttggtatgg
    49141 tagaaaaaga attgcatttt ccacaagtag acattgaaac agtagaaggt cctcttgcga
    49201 ctattaagac caatcacgga gacttacgta tcaagctttt ccctgaacat gctcctaaaa
    49261 cagtggctaa ctttgtatct ctttcaaaag atggctacta tgatggtgtc attttccacc
    49321 gtattatcaa ggactttatg atccaaggtg gagacccaac tggaactggt atgggtggcg
    49381 agtcaatcta cggcgaatct tttgaggatg aattctcaga agagctttac aatatccgtg
    49441 gtgctctttc catggcaaat gctggtccaa ataccaacgg cagccagttc tttatcgtgc
    49501 aaaaccaaca cctaccttat tctaagaaag aaattactcg tggtggttgg ccagaaccga
    49561 ttgcagaaat ctatgccaat caaggtggga cacctcacct agaccgccgt cacacggttt
    49621 ttggtcagtt agctgatgaa gcatcttacg ctgtcttgga tgtcattgct gctgttgaga
    49681 caggagctat ggacaagcca gttgaagatg ttgtaattga aactattgaa atcgaggact
    49741 aagatgaaaa tcggttataa gctaaagggg cgtattacag ggattcagcc ctacggtgcc
    49801 tttgttgagt tagagacggg tgatacgggg ctgattcaca tttcagagat tcggacagga
    49861 tttattgaaa atattcatga aaccttgaaa gtcgatgaag aggttcaagt tcaggtagtg
    49921 gatttagatg aatttacagg gaaagccagt ctttctatcc gcactttgga ggaagaaaag
    49981 taccagtttc ctagacggag acgcttttca agcgaccgct ttaactacgg ttttgctccc
    50041 tttcgacgaa tgctaccaat ctggactgga gaagccctgc accatttaaa aaagaagaag
    50101 tagtttagag ttttatattt tttgtaatgt taatataaat ttgctataat aggaccatgg
    50161 aagaagaaca attattaaaa tcaggagagc gcattaacca gctcttttcg acagatatca
    50221 aaatcattca aaatagagag gtttttagct attcggtgga tagtgttctc ttatcacgat
    50281 ttccacgttt tcctaagaag gggttgattg tggatttctg tgctgggaat ggagcagtgg
    50341 ggctttttgc tagcactcgt actcaagcac agatattgtc tgttgagatt caggagcgtt
    50401 tggcggatat ggctgaacgc tctgtccgtt tgaatggatt agaggagcaa atgcaggtca
    50461 tctgcgatga tttgaaaaat atgcctgctc acattcaggg gagtaaggtg gatatgattt
    50521 tgtgtaatcc accctatttc aaggtggatc cttattctaa tctgaacgag agtgaacatt
    50581 atctcttggc tcgacacgaa atcacgacta atttggaaga aatctgtcat agtgcccaga
    50641 gtattctcaa gtctaatggg cgtttggcca tggttcatcg tcctgatcga cttctggata
    50701 ttttggatac gttaaaacga cataatctag cccctaagcg cctgcagttt gtttatccaa
    50761 aaagagaaaa ggaagccaat atgcttttga ttgaggcgat caaggatggc tcaacaagtg
    50821 gctttaaggt cttacctcct ttgattgtcc acaatgatga tggctcttat acgcccgaaa
    50881 tcgaagagat ttattatgga tcataaggct tatatgtacg ttctggagtg tcgtgatgga
    50941 tcctactata taggctatac gactgatgtg agaagacgcc tcgctatcca caatagtggg
    51001 aagggagcca aatatacacg agcacgcttg ccagtcaaac ttatctatgc tcaaggtttt
    51061 gccagtaagg aagaagccat gtcggctgaa gctcttctca agcgtaagaa gaggccacag
    51121 aaggaagaat ttttatctga aaatcaagat agaaatttac tcagttattt tgaagaatcg
    51181 tggggagtcc tttgactcct cttacctttg tcaaaaagcg aaaaaaatgc tacaataaag
    51241 aaaataaaca aaatgaggta ttatcatgtc caagattcta gtatttggtc accaaaatcc
    51301 agactcagat gccatcgggt catctgtagc ttttgcctac cttgcaaaag aagcttacgg
    51361 tttggatacg gaagctgttg cccttggaac tccaaatgaa gaaacagcct ttgtcttgaa
    51421 ctattttggt gtggaagcac cacgtgttat cacttctgcc aaagcagagg gggcagagca
    51481 agttatcttg actgaccaca atgaattcca acaatctgta tcagatatcg ctgaagtaga
    51541 agtttatggt gttgtagacc accaccgtgt ggctaacttt gaaactgcaa gcccacttta
    51601 catgcgtttg gagccagttg gatcagcgtc ttcaatcgtt taccgtatgt tcaaagaaca
    51661 tggtgtagct gtgcctaaag agattgcagg tttgatgctt tcaggtttga tttcagatac
    51721 ccttcttttg aaatcaccaa caacacaccc aacagataaa atcattgctc ctgaattggc
    51781 tgaattggct ggtgtgaact tggaagaata tggtttggca atgttgaaag ctggtaccaa
    51841 cttggctagc aaatctgctg aagaattgat tgatatcgat gctaagactt ttgaactcaa
    51901 cggaaataat gtccgtgttg cccaagtgaa cacagttgac atcgctgaag ttttggaacg
    51961 ccaagcagaa attgaagctg caatgcaagc tgccaacgaa tcaaacggct actctgactt
    52021 tgtcttgatg attacagata tcgtcaactc aaactcagaa atcttggctc ttggtgccaa
    52081 tatggacaag gtcgaagcgg ctttcaactt caaacttgaa aacaatcatg ccttccttgc
    52141 tggtgccgtt tcacgtaaga aacaagtggt acctcaattg actgaaagtt ttaatgcgta
    52201 agattttggg tgtcagctca aaatcggaaa gtctagtttg ccttatatcg aaaggagttt
    52261 cggctccttt ttttctagga gtgaagtatg ttagaaaatg gcgatttgat ttttgtgaga
    52321 gatgggtcag acatgggaca ggccatccag acttccacag gtaactatag ccatgttgcc
    52381 atttatttgg atgggatgat ttatcatgct agtggacagg ctggtgttgt ctgtcaagaa
    52441 ccggcagact tctttgagtc caatcatttg tacgacctct atgtttatcc agaaatggat
    52501 atccagtcgg tgaaggaaag agcttgcaaa catcttggag caccctacaa tgcttctttc
    52561 tatccagatg cagctggttt ctactgctcc cagtatatag cagaaattct acctattttt
    52621 gaaactattc ctatgaaatt tggagatggg gagcaggaga ttagtgattt ttggagggag
    52681 tattacatag aactaggtct gcctgttcct ctgaaccaag ctggtaccaa tcctagtcag
    52741 ttggcagcat cgcctctgtt acaatgtaaa gaaaggaatc ttcatgattc agatttttaa
    52801 tccatctcgt ttgacgagac agccattttt ggagaattga tccgctatct ggaccagtat
    52861 gaggatgtga ttctacgggg aattaaggct caatttccag atgttgcagt tgataaactc
    52921 atggaagagt atataaaggc aagcttgatt ctacgtgaaa ataagcgcta ttacctcaat
    52981 tttcctacgc ttgaatcact tgatagtctt gaactggatc aagagatttt tgtcagagaa
    53041 gctagtccgg tctatcaagc cttgttggag cagagttttg agacggaatt gcgcaatcaa
    53101 atcaatgcag ctattttagt tgaaaagacg gactttgcgc gcattaaaat gaccctgtcc
    53161 aattattttt acaaggtcaa acagcagtat cctttgacag aaaaacagca ggagctctat
    53221 gacattttag gagatgttaa tcctgagtat gccctcaagt atatgacggc ttttttgttg
    53281 aaatttctca aaaaagacca gcttatgcag aaatgccgtg atatctttgt ggacagttta
    53341 gttgtcttag gctatattgt gcaaaatgaa gatggaaagt atgagttggc tatcgatttt
    53401 gataaggaga gattaacttt ctactagcgt gatttcttgt ttctgagcac attgtttgac
    53461 tttccttagt attcggtata aactatatgt aaccggtaac acatatcgga ataaactaaa
    53521 ggagacaatc atatgtcact tgaaaacaaa ttggaacaag caacaggcgc tgtcaaagaa
    53581 ggttttggta aagttactgg agacagcaag acagaacttg aaggagctgt tgaaaaaaca
    53641 gttgctaagg caaaagacgt tgtagaagac gcaaaaggtg ctgtagaagg tgccgttgaa
    53701 ggtttgaaaa acgtttttac taaataatag gaaaaaatca agggtttcat tttcccttga
    53761 ttttttctat tcttataaat aattttctgc gacggctgta tctcctgggt aggattcttt
    53821 cttgccctgg atgatttggt aacaatcggc tcccttaccc gcaataataa ctgcatctaa
    53881 ttcgtgattt gtgatagcca ttgccgcctt gatggcttct tggcgatccg caatcttttc
    53941 aacaggatga ttgatgtagc tactaatttc atctgcaatg gccattgggt cttcatagtt
    54001 agggtcatca gcagtcagaa agacttgaat ctcagggtgt tgattgagga ggaggccaaa
    54061 gtccttacga cgactttctc ccttgtttcc tgttgatccc agaaccagag caatctttcc
    54121 ggtttgatga gtttcaacca cattgatgag ttttttcaga ctatccccat tgtgggcata
    54181 gtcgatgaag accttggctc catttttctg agtgaggact tccatacgac caggaacgcg
    54241 ggttgcagcg atgccttttt tgatgtcctc aagacttgct ccgagacgga gacaagcaag
    54301 tccagcagca actgcatttt cttggttgaa gttgccaatg agttggatat cataatctcc
    54361 agcgagttta cccgtagctg aaaagctaaa ggctttggaa ttctcgattt ggttatcaaa
    54421 ttggctacca tagaaatcat ggtcttgatc ttcaacctgt tctttcaaga ctgagaagtg
    54481 gtccatgtca ctgttaatga tgactgctcg gctattttcc atcaagagac gcttgtggta
    54541 gaaatagtct tcaaagctag ggtgttcaat cgggccgata tggtctgggc tgatattgag
    54601 gaaaactccc acatcaaagg ttagaccata gacacgtttg accagatagg attgactgga
    54661 gacttccatg atgaggtggg tacggtcatt ttgcacagcc tgattcatca tgtcaaagag
    54721 gtcaatactc tcaggggttg tcaacgctga cttaaagaaa gtctcgccat caagagttgt
    54781 gttcatggtc gacaacatag caggtctatg cccttgagat aagatgttat aggcgaaata
    54841 ggttgctgtt gtcttaccct tagtaccagt aaaggcaagg agtttgagtt tctcttgtgg
    54901 attaccatag aactccatgg caatcaaact catggctttc tttatatcgt tcacaatgat
    54961 gacagggata tcgacttcgt agtccttttc agctacatac caagctaaac cttgtgttat
    55021 agcagaaaga aggtattctt ttttaaaggc agcgcctttt gcaaaaaaaa gagtgtcttc
    55081 tgttactttt cggctgtcgt agctgatgct atcaaaaata actttgctgt agttgtagtg
    55141 gtaatgacct tggtcaataa tttcgcgaaa aaggccatct ttctttaaaa tatctaatac
    55201 ggtttcaatc ttaatcatac tttctattgt aaaccgaaag tcgtaaattt acaagtaaca
    55261 aggaaaagtt tataatggaa gatgaggagt ttttcctagc tatcaaaatt gaatgaggaa
    55321 tctatgtcgc acgaaaacaa tcaccagcag gcccagatgt tacgggggac tgcttggcta
    55381 acggctagta actttatcag tcgcctactc ggggctgttt acattatccc ttggtacatc
    55441 tggatggggg cttatgcagc taaggcaaat ggtctcttta ccatgggtta caatatctat
    55501 gcttggttct tgttggtttc aacagcgggg attccagttg cggtggccaa gcaagttgcc
    55561 aagtataata ccatgcgaga agaagagcat agctttgccc tgattcggag cttcttaggc
    55621 tttatgacag gactaggcct ggtttttgct ttagtcttgt atgtctttgc tccttggcta
    55681 gcagacttgt ctggcgtggg taaagacttg atcccaatca tgcaaagctt ggcttgggga
    55741 gtcttgattt tcccgtctat gagtgttatc cgaggatttt tccaagggat gaataacctc
    55801 aaaccctatg ccatgagcca aattgctgag caggtcattc gtgttatctg gatgctccta
    55861 gcaaccttta tcattatgaa gctcggttca ggagattatc tagcagccgt tacccaatca
    55921 acctttgctg cctttgtcgg tatggtagcc agttttgcag tcttgattta tttccttgcc
    55981 caagaaggtt cactcaaaag agtctttgaa acaggagata agattaacag taagcgtctc
    56041 ttggttgata ccattaagga agccattcct tttatcctga cagggtctgc catccagctc
    56101 ttccagattt tggatcagct gacctttatc aatagtatga gctggtttac caactacagc
    56161 aatgaggact tggttgtcat gttttcttat ttctcagcca atcctaataa aatcacgatg
    56221 attttgattt ctgtaggggt ttcgattggg agtgttggtt tgccactttt gacggaaaac
    56281 tatgtcaagg gggacttgaa agcggcttct cgtctcgttc aggacagtct caccctactc
    56341 tttatgttct tgctaccagc aacggttgga gtggttatgg taggagaacc tctttatacg
    56401 gtcttctatg gtaagccaga tagtttggct ctgggcttat ttgtctttgc agttttgcag
    56461 tctattattt taggcttgta catggtcttg tctccaatgc ttcaggccat gttccgcaac
    56521 cgcaaggccg ttctctattt tatctatggt tctattgcca agctagtctt gcaactacct
    56581 accatcgccc tcttccacag ttatggtcct ttgatttcaa caaccattgc tctcatcatt
    56641 cctaacgtct tgatgtatcg ggatatttgt aaagtaactg gtgtcaagcg caaggtgatt
    56701 ttgaagcgaa ccattttaat cagtttgctg accctagtca tgtttctgtt aataggaacc
    56761 atccagtggc tgttaggatt tttcttccaa ccaagtggac gtttgtggag cttcttttat
    56821 gtagctcttg tcggtgccat ggggggtgga ctttatatgg ttatgagtct gcgtacctat
    56881 ttattagata aggtaatagg aaaagcccaa gcagatcgcc tgcgagcaaa atttaagctt
    56941 tcgtaaggta gcatttataa ataaaaggaa taagttgaac aatcttttag gagaacttga
    57001 aacttattcc ttttttagcg tcaaaatagc taaaattatc tttcaaaaat agaaaatgag
    57061 gtttttttga ttttttggaa aaaacaattg actaaacaaa ccaagagttg tataataaaa
    57121 caaatattta aagcaggagg ttctggaaat gaaaaagtct aagagcaaat atctaacctt
    57181 ggcaggtctt gtcctgggta caggagtttt attgagcgcg tgtggaaatt ctagcactgc
    57241 atcaaaaacc tataactatg tttattcaag tgatccatct agtttgaact atctagcaga
    57301 aaaccgcgca gcaacatccg atattgttgc aaatttggta gacgggttat tagaaaatga
    57361 ccaatatggg aatattattc catcattagc agaggattgg actgtttctc aggacggttt
    57421 gacctatacc tacaaacttc gtaaggatgc caagtggttt acttctgagg gagaagaata
    57481 tgcgcctgta actgcccagg attttgtgac aggtttgcaa tatgcagctg ataaaaaatc
    57541 agaagctttg tatctagtgc aggactctgt tgctggtttg gatgactata tcactggtaa
    57601 aacaagcgac ttttcaactg tcggtgtcaa ggcacttgat gaccaaacgg ttcaatatac
    57661 tttggttaaa ccagaacttt actggaattc aaaaacactt gcaacgatac tttttcctgt
    57721 taatgcagat ttcctgaaat caaaagggga tgattttggg aaggcggatc catctagtat
    57781 tttgtacaat ggacctttct tgatgaaagc acttgtctca aaatctgcta ttgaatataa
    57841 gaaaaaccct aattactggg atgctaagaa tgtctttgta gacgatgtga aattgaccta
    57901 ctatgatggt agcgaccaag aatcactgga acgtaatttt acagctggtg cttatactac
    57961 ggctcgtctt tttcctaaca gctccagcta tgaagggatt aaagaaaaat acaaaaacaa
    58021 tatcatctat agtatgcaaa attcaacttc atatttcttt aattttaacc tagataggaa
    58081 gtcttacaat tatacttcta aaacaagtga cattgaaaag aaatcgaccc aggaagcagt
    58141 tctcaataaa aacttccgtc aggctatcaa ttttgctttt gacagaacat cttatggggc
    58201 tcagtctgaa gggaaagaag gtgcaacaaa gattttgcgt aacctagtgg ttcctccaaa
    58261 ctttgtcagt atcaagggaa aagactttgg tgaagttgta gcctctaaga tggtcaacta
    58321 tggtaaggaa tggcaaggta tcaactttgc ggatggtcaa gacccttact acaatcctga
    58381 gaaagccaag gctaagtttg cggaagctaa gaaagaactc gaagcaaagg gtgttcaatt
    58441 cccaatccac ttggataaga ctgtggaagt aacagataaa gtaggcatac aaggagttag
    58501 ttctatcaaa caatcaattg aatctgtttt aggttctgat aatgtagtga ttgacattca
    58561 gcaattaaca tcagatgagt ttgacagttc aggctacttt gctcaaacag ctgctcagaa
    58621 agactatgat ttatatcatg gcggttgggg acctgattat caagacccgt caacctatct
    58681 cgatattttt aatactaata gtggaggagt tctacaaaat cttggactag agcctggaga
    58741 agccaatgac aaggctaagg cagttggact ggatgtctat actcaaatgt tggaagaagc
    58801 taataaagag caagatccag ccaaacgtta tgagaaatat gctgatattc aagcttggtt
    58861 gattgatagt tctttagttc ttccaagtgt ttcgcgtggg ggaacaccat cattgagaag
    58921 aaccgtacca tttgctgctg cctatggttt aaccggtaca aaaggggttg aatcatataa
    58981 atacctcaaa gtacaagata agattgtcac aacagacgaa tatgcaaaag ccagagaaaa
    59041 atggttgaaa gaaaaagaag aatccaataa aaaagcccaa gaagaattgg caaaacatgt
    59101 caaataaaat ctaattgtag ataagtttgt gtaagaagtc tttgtgctta aaaacgcata
    59161 atatcaggta tataaaatcc tagatgttat gcgttttgtt ataggaagat ttattagatt
    59221 ttatcctcaa attgagttat tcccgacttt atccgttgaa atattataag gagtatttat
    59281 gaaattaaaa ttattaagag tagatactaa ggtgattatg gggagtttct tacttgttct
    59341 gtctagtcta cttgctttgt tgcttcccct tatcttaaag ggtttaatag atgggagttc
    59401 tattgaaaat ataggttcca aagtatttca atcgtattgg tcaagccttg ttttcttcta
    59461 ttggttacta tctgtttagt caatcgggtg aaaaaaagat agcaaaaatc aggaaaaaag
    59521 tgatagaggg gttgatttat gcagagaaat ccttctttga taagagccaa agtggggagt
    59581 tgacttctgc cattgtcaat gacatgagtg tcattcgtga gtttttaatt acgactttcc
    59641 caaatattat tctgagttta gttatggtac ttggttccat tgtagtctta tttagtcttg
    59701 attggaatct ttctctactt ttattcatca ctcttccttg tatgatgttt attatcttgc
    59761 ccctttccaa tatcagtgaa aagtatagtc gtcgtttaca ggaggaaatt taacagggca
    59821 attgactgaa aagattcaag aacatgaatt aattaagact aaccaagcag agaaaagtgt
    59881 acaggatgtt ttggataatt gtattgaaag ggtacaaaac aattcactga aatcagatag
    59941 ggttacttct tttgagaccc cgtttgctct cttatttatc tttgcgacta tagctgtgat
    60001 gctaacctat gggggttatc gggtcagcgc aggatatata tctgtgggaa ccttggtttc
    60061 gtttttgatt tacctctttc aattacttaa tcctattagt aatatagcta attttgtaac
    60121 tgtttattct aggagcaagg gatcttcagt tgcactggat aacttgcttg cagttcctaa
    60181 agaaaaattt gagggaggaa aatcggtatc aggacaaggg ttgaatttta accatgtcta
    60241 ttttggttat gatgaaaatc gacctgtctt aaaggatatt acttgttcaa ttttcaaggg
    60301 gcaaaaattg cttttgttgg accatctgga tcaggaaaat caacgattgt gcgtttgtta
    60361 gagcggtttt ataaaccgct ttcaggagat attctaatgg agcaatcaag tatatatgat
    60421 tttaacttaa aagaatggag aagtaaaatc gcttgggttt cacaaaataa tgcagtctta
    60481 tctggcagta ttcgtgacaa tctttgtctc ggtttgaatc gcttagtaac tgatgatgaa
    60541 ttgatgaaag tgctagactt agtatcacta ggtgatgaga ttcgctccat gaaagaggga
    60601 ctagatactg aagttggtga acgcggacga ttcttgtcag gggggcaaag ccaaagactt
    60661 caaatagcta gaacctactt aaaagatgct gaaattctta tatttgatga agctactgct
    60721 aatcttgatg cggattctga gtatgcgatt atcagtagcc tctattctgt attaaaggag
    60781 aagacggttg tgattatagc gcatagtttg tcaacggtaa aagatgtgga ttgtattttc
    60841 ttcttagagg aggggaaaat cactggctca ggaactcata aggaactact ggaaaatcat
    60901 gagcgttatg ctcgttttgt gcaggagcaa atgatagagt gaagtgtctt ttgagattca
    60961 ccattttata gtctattaaa gggagcagga aaaactccct ttttatatag tttgaaacta
    61021 taactagctc ttgaaaagaa gaaaatgagt tgatgaaaat aagtggtaca atagttacta
    61081 tagatttgga ggtattgtat gagcaaggaa ttacacatta acacaatttt ggcccaggcg
    61141 ggtattaagt cagatgaagc gacaggtgca ttggtgacac cgcttcattt ttcaacgacc
    61201 tatcagcatc cagagtttgg tcgatctact gggtttgact atacgcgcac taaaaatcca
    61261 actcgtagta aggctgagga agtcttggcg actattgagt cagcagacta tgccttagcg
    61321 actagctcag ggatgtcagc tattgtactg gcctttagcg gctttccagt aggaagtaag
    61381 gtcttggcag tgcgtgatct ttacggcggt tcttttcgct ggtttaacca agtggagcag
    61441 gaaggtcgtt tccattttac ctatgccaat acagaagaag agttgattgc cgagttagaa
    61501 aaggatgtgg atgttctcta tatcgaaacc ccaaccaatc ccttgatgtt ggaatttgat
    61561 atcgaaaaac tagcaaaatt ggctcatgct aagggtgcca aagtggtggt ggacaatacc
    61621 ttctatagcc ctatctacca acgtccgatt gaagatggag cagatatcgt tctccattca
    61681 gcaaccaagt atctagcagg ccacaatgat gtcttggctg gagtggttgt gaccaatagt
    61741 ttagaactat acgagaagct tttttacaat ctcaatacaa caggggcagt cttgtctcca
    61801 tttgacagct accagttgct tcgtggtctc aagaccttgt ctcttcgtat ggagcgctca
    61861 acagctaacg cccaagaagt ggttgccttt ttgaaggatt ctccagcagt taaggaagtt
    61921 ctctacactg gtcgtggagg catgatttcc tttaaagtag ccgatgaaac acgcattcct
    61981 catattttga acagtctcaa ggtcttctct tttgcggaaa gtttgggcgg agtggaaagt
    62041 cttattactt atccaacgac tcaaactcat gctgatattc cagcagaagt acgccattct
    62101 tatggtttga cagatgacct cttgcgtttg tctattggga ttgaggatgc tagagatttg
    62161 attgcagatt tgcgccaagc cttagaagga taagacaaag atgggaaaat atgattttac
    62221 aagcctgccc aaccgtttag ggcaccatac ctataaatgg aaagaaacag aaacggatag
    62281 tgaagttcta ccagcttgga tagcggatat ggactttgtg gtcttgcctg aaatccgcca
    62341 agccgtgcaa acttacgcag accaactggt ttatggttat acctatgcca gtgaagactt
    62401 aattaaggaa gttcaaaagt gggaagctac acaatacggt tacaactttg acaaagaggc
    62461 tcttgtcttt atcgagggtg tggtaccagc catctcaaca gctattcaaa cctttacaaa
    62521 agaaggcgag gcggttttaa ttaacacgcc tgtctaccca ccctttgctc gcagtgtcaa
    62581 gttgaataat cgtagattga ttactaattc cttagtggaa aaggatggtc tgtttgagat
    62641 tgactttgac caacttgaaa aggatttggt ggaagaggag gttaaactct atattctttg
    62701 caaccctcac aatcctggtg gacgtgtttg ggaaaaagaa gtgttggaga agattggcca
    62761 actctgccaa aaacacggtg ttttgttagt ttcggatgag attcaccaag atttgaccct
    62821 ctttggtcac aaacaccagt ctttcaatac catcaatcct gccttcaaaa attttgctat
    62881 cgtcttgagt agtgccacta aaacatttaa tattgctgga acaaaaaatt cctatgcagt
    62941 cattgaaaat cctaagttga gactagcttt ccagaaacgc ctgttggcca ataatcagca
    63001 tgaaatttca ggcttgggtt atttggcgac agaagctgcc tatcgatacg gtaaagattg
    63061 gctagaggaa ctcaagcaag tctttgaaga ccacatcaat tatgtggtgg atctatttgg
    63121 aaaagagact aaaatcaagg tcatgaaacc gcaaggtacc tacttgattt ggcttgactt
    63181 ttcagcttat gacctgactg atgaaacatt gcaagagttg ttgagaaatg aagccaaggt
    63241 tatcctcaac cgtggtttgg attttggaga ggaaggaagt ctccatgccc gcatcaatat
    63301 agctatgccc aaatctctgt tgcaagaagt ctgtcagcgg attgtggcta cttttgccaa
    63361 acgttaaaaa tccagccttc taggagaaaa gtcttcctag aaggctattt tcataggcga
    63421 aaatatggta taataaaaag ataaggtaaa ggtgaaaata tggctaaatt gattccgggg
    63481 aaaattcgta tcgaaggtgt tgccctttat gaaactggta aggttgatat catcaaggaa
    63541 aagaacaatc ggctctacgc tcgcgttgca gaagaagaac tgcgctatag tttagaggat
    63601 gatttggttt tttgtgcctg tgattttttt caaaagaggg gttactgtgt gcatttggca
    63661 gcgctagagc attttctgaa aaatgatgag cgtggtcagg aaatcttgtg gagtctggaa
    63721 gaaggtcatg aagaaaaaga ggctgttgaa accaaggtaa ccttgggtgg caagtttttg
    63781 gatcgaattt tatctccaaa atcagaatgc gcctatgagt tatcagctgt gggtcaggtg
    63841 gaagcaggaa ccaatcatat cttgtggact ctgagaatcg gccaaatcaa tagccaaaaa
    63901 tactatgtca ttcgggatat tccacttttt ttaaggattg tcgagcagag aaagtcgtat
    63961 atgattggca agatttatga ggagtctctt tcttgggaag cctttgatga tgccagccaa
    64021 gaacttttga ctttcttgca cggactaacg gaggaagggc tggtttcaga cctctttttc
    64081 caaaaccaag gtcggcacct ctttttccct ctgacctttt ttgagcaggg tgtgaattta
    64141 ctgatggcct tgccccattt tcaatttgac catcaagtgg atagctacca aaccctgctt
    64201 tttcaggata tgcatgctga tgccaatcta tttgccttta cagtaacaga atactcggac
    64261 tattttgaaa tggaaatcag tgagagtcct agggtcaatg tcttttatca gggagcagta
    64321 cttttccata aaggtcaggt ttatttttta acagaccagc agatgcgtct tctcaaggaa
    64381 attaaagcgt tacctgtggg tcaacaagga aagaaatacc tgcaatttga tagcagtgat
    64441 cgagacaaat tggcctcctg tctgactctt tttatccaga tgggcaccgt ttcagctcca
    64501 gaacgtctac aaatcaaaac ttttgcgccc tctttttact ttgacaggga agaagataat
    64561 cggattcgtt tagaaattca gtttgattat ggaaatagac aggtatctag ccgacaagag
    64621 ctagaagaat taccattttc aagtgacgcg gacttagaag aaagaatttt ccaagtctgt
    64681 ttggctgcgg gctttgaagc cgattttcaa tcttggcgtc aggccttaaa agcggagtct
    64741 gtctatcatt tttttcatga tatcattcca gtctttgaaa aactcgggca tgttgaccta
    64801 tcagataaac tagaagagct ttatagccta gcgagtcctc aggtgcagat tgcctccaag
    64861 ggaggtctct tggaaatcca gtttgatttt caagatattg cccaggagga aatcgaccaa
    64921 gccatgcagg ccttggttgc caatcaggat ttttatattg attcgtctaa tcaagtttac
    64981 tttttcgatg aagaaaccaa gaaaattcgc caaaatctac aggaactggg gcaatttgaa
    65041 ttaaaagatg ggaccttgca ggctcggaaa tccttggcct acagtttagc tcatctcttt
    65101 gaagggcgag accgtgtttc tttttcacaa gaattccaga atctggccca ggatttgaca
    65161 catccagagg actttcctcg acaggcaact caggttcagg ctgacttgcg agattatcag
    65221 gaaaagggaa ttggctggtt gcagatgctc catcattatg gttttggtgg gattttggct
    65281 gatgatatgg gacttgggaa aacccttcag accattgctt ttttgactag tcaagtgaca
    65341 aaagaaagtc gggttttgat tctcgctccg tcaggtttga tttacaactg ggcagatgag
    65401 tttcagaaat ttgccccaca gttggatgtg gctgttgttc atggtttgaa agcaagtcgt
    65461 gaggagattc ttgccgagag ccatcaaatc tatgtgacta gctatgccac cttccgtcag
    65521 gacagtgagt tttatcaggg gatggccttt gacttccttt tcttagatga ggctcaggtc
    65581 atgaaaaatg cccagaccaa gattgcccag accttgagac aatttgtggt gccgtcggtc
    65641 tttgccttgt caggaactcc gattgaaaac catctgggtg agttgtggtc tattttccaa
    65701 atcgtcatgc ccggactttt gccaagcaag aaagaattta tgaaattgcc agcagagcga
    65761 gtggctcagt ttatcaagcc tttcgtgatg cgacgcaaga aagaagaagt tctgactgaa
    65821 ttgccagact tgattgaggt ggtttataaa aatgaactgg aagaccagca aaaggctatt
    65881 taccttgccc agttacaaca gatgcgagac catctggctc aagtgtcaga acaggaattt
    65941 cagcgaagtc gtgtggaaat tttatctggt ttgatgcgct tgcgtcaaat atgtgacact
    66001 cctgccctgt ttatggaaga ttatcaggga gccagcggca aactagatag tctccgagac
    66061 ctactggtac aggtggcaga cggcggacac cgtgtcttga ttttctctca gttcaaggga
    66121 atgttggaaa aaattgaaca agaactgcca gacttgggcc tgacatcctt taaaattacg
    66181 ggttcaaccc cagccaagga aagacaagac atgaccaagg cctttaacca aggagaaaga
    66241 gatgcctttc tgatttccct caaggctggt ggggtcggtc tgaacctgac aggtgcagat
    66301 acagtgatct tggttgacct ttggtggaat cctgcggtgg aagcgcaagc cattggccgt
    66361 gcccatcgga tgggtcagga agaaacggtt gaggtctatc gcttggtgac caagggaacc
    66421 attgaagaaa aaattcagga actccaagaa caaaagaaac atctggtgtc acaagtattg
    66481 gatggcacag agtcacgtgg tagtctgacc ctagcagaaa ttagagaaat tttgggaatt
    66541 tctgaagcca gcacttgaaa aatcaagaca atacgctata atgaagtgtt gaaaggaaat
    66601 agaaaatgaa acaagaacga tttccattgg tgtcagatga cgaggtcatg ttgactgaaa
    66661 tgccagtcat gaatctctat gatgagtctg atctgatcag taatatcaag ggtgagtatc
    66721 gagataaaaa ttatttagaa tgggctccta ttactgaaga aaaaccagta aaaccgattg
    66781 aaaagcaagt cgaaaaacct aaaaaggctc ctttaggggt taaaaaagaa ggaaagagct
    66841 atgcggaggt ggcgcgtgaa gaagcgcgtg cggacttgaa aaagaaacgc tctgctaact
    66901 acctaactca ggatttcagc cttgcgagac gtcattctca gcccagtcta gttagacagg
    66961 gcaatcaacc gacaactcct ttccaaaagg aaaatcctgg tgaatttgtc aaatatagcc
    67021 aaaaattgac ccagtctcat tatatcttgg cggaagaagt tcattctatc cctaccaaga
    67081 atgaagaagt gtcagcacct gctccaaaga aaaacaatta tgattttcta aagaagagcc
    67141 aaatctacaa taaaaaaagt aaacaaacag aacaagaacg tcgggttgcc caagagttga
    67201 atctgaccag aatgacagaa taggggagaa aacatgtcaa agacatatca ttttatcgga
    67261 attaagggat cagggatgag tgccttggcc ttgatgttgc accagatggg gcacaaggtt
    67321 cagggatcag atgttgaaaa gtactacttt acccaacgcg gtcttgagca ggcaggaatt
    67381 accattcttc cttttgatga aaagaatcta gacggtgata tggaaattat cgctggaaat
    67441 gcctttcgtc cagataacaa cgtcgaaatt gcctatgcgg accaaaatgg tatcagctac
    67501 aaacgttacc atgagtttct aggtagcttt atgcgtgact ttgttagcat gggagtagca
    67561 ggagcacatg gaaaaacttc aacgacaggt atgttgtctc atgtcttgtc tcacattaca
    67621 gataccagct tcttgattgg agatgggaca ggtcgtggtt cggctaatgc caaatatttt
    67681 gtctttgaat ctgacgaata tgagcgtcac ttcatgcctt accacccaga atactctatt
    67741 atcaccaaca ttgactttga ccatccagat tatttcacaa gtctcgagga tgttttcaat
    67801 gcctttaacg actatgccaa acaaattacc aagggtcttt ttgtctatgg tgaagatgct
    67861 gaattgcgta agattacgtc tgatgcacca atttattatt atggttttga agctgaaggc
    67921 aatgactttg tagctagtga tcttcttcgt tcaacaactg gttcaacctt caccgttcat
    67981 ttccgtggac aaaacttggg gcaattccac attccaacct ttggtcgtca caatatcatg
    68041 aatgcgacag ccgttattgg tcttctttac acagcaggat ttgatttgaa cttggtgcgt
    68101 gagcacttga aaacatttgc cggtgttaaa cgtcgtttca ctgagaaaat tgtcaatgat
    68161 acagtgatta ttgatgactt tgcccatcat ccaacagaaa ttattgcgac cttggatgcg
    68221 gctcgtcaga aatacccaag caaggaaatt gtagcagtct ttcaaccgca tacctttaca
    68281 agaaccattg ccctgttgga cgactttgcc catgctttaa accaagcaga tgctgtttat
    68341 ctagcgcaaa tttatggctc ggctcgtgaa gtagatcatg gtgacgttaa ggtagaagac
    68401 ctagcaaata aaatcaacaa aaaacaccaa gtgattactg ttgaaaatgt ttctccactc
    68461 ctagaccatg acaatgctgt ttacgtcttt atgggagcag gagacatcca aacctatgaa
    68521 tactcatttg agcgtctctt atctaacttg acaagcaatg ttcaatagga tgttcccatg
    68581 gaaattccaa ttaagatcat tcaggcaagc aagtctgatt tgcctgagat aggggcactt
    68641 cagacctcgt cttttccagc tgaaaagcag caactttccc atattttaga agaaagtatc
    68701 cgtaagtgtg cggatacctt tcttctagct agggatgaaa atcaactttt aggctatatt
    68761 ttatcaagtc cccagtcaga caatccgcaa tgtctaaaag tacattcttt agtcatcgag
    68821 tctgaccatc agagacaggg cctgggaaca cttcttcttg cagccttgaa agaggtggca
    68881 gttgagctgg attgcaaagg gattcgtttg gagagtcctg atgagctgct ttcctatttt
    68941 gaaatgaacg gttttgttga tgaagaagaa actttgctct atgcaactag ccagggctat
    69001 agtatgattt ggtttaatcc cttttatctg gaggaacaat gaaaatcaga caagcaagat
    69061 tagaagattt ggatcggatt gttgaacttg aatttgaaaa tttttcggtc gaagaagcca
    69121 ttcctccttc tgtctttgaa gcacatttga gagaaattca gacctctttt ctggttgctg
    69181 aaaaagaagg aagaatcatg ggttatatcg aaggaccagt tggcctgcac cgccatctgc
    69241 aagaccagtc ttttacagaa gaaataaaag actatagtca tgagcctggt ggttatatct
    69301 ctgtgacctg tctgtctatt gccaaggagg cacagggact cggactgggt cagaaattgc
    69361 tgacagcctt gaaagaagtt gctcttgaag atgagagaga tggcattaat ctaacctgtc
    69421 atgactatct catcgcctac tatgaaaaac atggatttgt caacgaaggc cagtcccagt
    69481 caacctttgc aggggaaaca tggtatgata tggtctggga aatgaaaaaa taagttagga
    69541 aaagtatcat agattgcttt ttttggactt ttaagatata atattatgga ttatcaacaa
    69601 ggaggaaaaa cttttgagtg aaaagtcaag agaagaagag aaattaagct ttaaagagca
    69661 gattctgaga gatttagaaa aagtaaaagg ctatgatgaa gttctgaaag aagatgaggc
    69721 agtagttcgc actcctgcaa atgaaccttc agctgaagaa ctcatggctg attccttgtc
    69781 aacggtagag gagattatga gaaaagctcc taccgtgcct actcacccaa gtcaaggtgt
    69841 accagcttct ccagcagatg agattcaaag agaaactcct ggtgttccaa gtcatccaag
    69901 tcaagatgta ccttcttctc cagcggaaga aagtggatca agaccaggtc caggtcctgt
    69961 tagacctaag aaacttgaaa gagaatacaa tgaaacccca acaagggtag ctgtttccta
    70021 tacgacggca gagaaaaaag cagaacaagc aggtccagaa acacctacgc ctgctacaga
    70081 aacagtggat atcatcagcg atacatcacg tcgtagccgt agagaaggag caaaacccgt
    70141 taaacctaag aaagagaaga agtcacatgt gaaagctttt gtgatttcat tccttgtatt
    70201 ccttgccttg ctctcagcag gtggttactt tggttaccag tacgtgctag attctttgtt
    70261 acctatcgat gctaattcta agaaatatgt gacggttgga attccagaag gttcaaacgt
    70321 tcaagaaatc ggtacgacgc ttgaaaaagc tggtttggta aagcatggtc tgatttttag
    70381 tttttatgcc aagtataaaa attataccga cttgaaagca ggttactaca atttgcaaaa
    70441 gagtatgagt acagaagact tactcaaaga gttgcaaaaa ggtggaacag atgaaccgca
    70501 agaacctgta cttgcgactt tgacaattcc agaaggttat accttggatc agattgctca
    70561 aactgtgggt caattgcaag gtgacttcaa agagtctttg acagcggagg ctttcttggc
    70621 taaagttcaa gatgagacgt ttatcagtca agcagtagcg aaatatccta ctttactgga
    70681 aagtttgcct gtaaaagaca gcggtgcgcg ttatcgtttg gaaggatacc ttttcccagc
    70741 tacatactct atcaaggaaa gcacaactat tgagagcttg attgatgaga tgttagctgc
    70801 tatggataag aacctatctc cttactatag tactatcaaa tctaaaaact tgactatcaa
    70861 tgagttgttg accattgctt ccttggtcga aaaagaaggt gccaagacag aagatcgtaa
    70921 gctcattgca ggtgtattct acaatcgttt aaatcgtgat atgccacttc aaagtaatat
    70981 tgcaatcttg tatgcccaag gaaaactggg gcaaaatatc agtctagctg aggatgttgc
    71041 gattgatacc gacattgatt caccttataa tgtttataaa aatgtaggtc tcatgcctgg
    71101 tccagtcgat agtccaagtc tggatgcgat tgagtcaagc atcaatcaaa ctaagagcga
    71161 taacctctac tttgtagcag atgtcacaga aggcaaggtc tactatgcta acaatcaaga
    71221 agaccacgac cgcaatgtcg ctgaacatgt caacagcaaa ttaaactaaa caaactaaaa
    71281 ttatgtgata cttcacataa ttttctttag aaaatattat cagaagaaag ttgagaaaaa
    71341 tggcagaaaa aacatatcct atgacccttg aggaaaagga gaaacttgaa aaagaattag
    71401 aagaattgaa attggttcgt cgaccagaag tggtagaacg cattaagatt gcccgttcat
    71461 acggtgatct ttcagaaaac agtgagtacg aagcagctaa ggatgaacaa gcctttgtcg
    71521 aaggacaaat ctctagctta gaaacaaaaa tccgctatgc tgaaatcgtc aatagcgacg
    71581 cagttgccca ggacgaagta gcgattggta aaacagtcac catccaagaa attggtgagg
    71641 acgaagaaga agtttatatt atcgtaggtt cagctggtgc ggatgccttt gcaggtaagg
    71701 tttcaaatga aagcccaatt gggcaggcct tgattggcaa gaaaacaggt gacacagcaa
    71761 ccattgaaac gcctgttggt agctatgatg taaaaatctt gaaggttgaa aaaacagcct
    71821 aaaaacagaa aaaggagtgg ggaggcgatg tgcttcactc actccttttt ccattttgct
    71881 attcttcgaa aatctcttca aaccacgtca gcgtcgcctt gccgtatata tggttactga
    71941 ctttgtcagt ttcatctaca acctcaaaac catgttttga gctgacttcg tcagtttcat
    72001 ctacaacctc aaaacggtgt tttgagcagc ctgcgcctag tttcctagtt tgctctttga
    72061 tttttattga gtattagatg tatagtgcat tgaagttaaa atagtacact ttgatttcta
    72121 agacattgtt agaaattaga ttaaattcct taatcgattt gcgcatgttt tatttcattt
    72181 cattatactt tagattggaa aataaggaat cacataaatc gcaagaaata gggaatctga
    72241 ttcgtgttta taaccgttca aaaagagaag aggctgaaag tgagccactt aatctttatg
    72301 tcgaagatga aaagggcaat ctccttgcgg gtttgatagc agagactttt ggaaattggc
    72361 tagaaatcga gtatttgttt gtaaaagagg aactgcgagg gcaaggaatc ggttcaaaac
    72421 tattgcaaca ggcagaaagt gaagctaaga atcgaaattg ttgttttgcc tttgtcaata
    72481 cttaccagtt ccaggcaccg gacttttatc agaaacatgg ctacaaggaa gttttttctt
    72541 tgcaagacta tctctacatt aggcaaagat attattatca aaagaatctg taaggtgagt
    72601 atggaggtgg actgatatat atgagtaact atcgataaat accagttata acctagaaat
    72661 tgtgtctttc tagacgatat tgaggacaat ataatcgtag ccccaaaatt aggaatcaag
    72721 gcttatcagg ttaagaaaag aagtgatgtt gttgatattt taaaacaatt tatttaaact
    72781 aaaaactctc tatcttttta aattgacatt aatccgagat tcccctctcg gattttgtgt
    72841 tgctttcatt aaatttacag gtaagacttg ctagcttcag taaatataca caagtttttc
    72901 agaatagagt gaaatccaaa agaaaatgga aataatgaaa gctcttgtag gcataagaaa
    72961 acacctttgt gttatacttg ttgttcaacc acaaacacaa gaaaggcaca gagatgcaaa
    73021 accattatac tacaaaaggc gaacaaaggg aaatcaaata gagaaattgc ctctctgctt
    73081 ggaaaagttc ctcaaactat ccacactgaa atcaagcgtg ggacagtccg acaatgtctt
    73141 ggaaaagggc gcttcaaaga ggtttattct gccgactatg ctcaacagtc ttatgaaaac
    73201 aatcgcaagc gctcggtcag gaaattaagc gtgaccaagg aactaaagga aaagattctc
    73261 cactatcata accaaaaatt ttcgcctgaa atgatggtga tggctaaagg ggttaacgtg
    73321 ggaatttcaa ccatttacta ttggattcat catggaaaat tggggttaag caaacaggat
    73381 ctgctttacc ctagaaaagg aaaagcgctt aagaaacagg ctagcatcaa ctttaaacct
    73441 gctggtcaat ccatcgcaca gcgg
//
LOCUS       DBERMM010000007        66825 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.007, whole genome shotgun sequence.
ACCESSION   DBERMM010000007 DBERMM010000000
VERSION     DBERMM010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 66825)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 66825)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..66825
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.007"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(529..2256)
                     /gene="ezrA"
                     /locus_tag="ACL8AS_000595"
     CDS             complement(529..2256)
                     /gene="ezrA"
                     /locus_tag="ACL8AS_000595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation ring formation regulator EzrA"
                     /protein_id="HGS1228507.1"
                     /translation="MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEE
                     LYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSF
                     RFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
                     AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIV
                     DRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENI
                     RQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLG
                     EDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDL
                     QTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTF
                     LKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQ
                     LLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSY
                     EKTRETIRF"
     gene            complement(2338..4284)
                     /gene="gyrB"
                     /locus_tag="ACL8AS_000596"
     CDS             complement(2338..4284)
                     /gene="gyrB"
                     /locus_tag="ACL8AS_000596"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005694 - chromosome [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HGS1228508.1"
                     /translation="MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLH
                     HLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVF
                     TVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVAD
                     LEIVGDTDKTGTTVHFTPDPKIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKREG
                     LEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVM
                     SFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISV
                     KHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARV
                     AAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQ
                     AILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDAD
                     VDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQ
                     EALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDM
                     LMGDRVEPRREFIEENAVYSTLDV"
     gene            complement(4299..4862)
                     /locus_tag="ACL8AS_000597"
     CDS             complement(4299..4862)
                     /locus_tag="ACL8AS_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HGS1228509.1"
                     /translation="MKYHDYIWDLGGTLLDNYETSTAAFVETLALYGITQDHDSVYQA
                     LKVSTPFAIETFAPNLENFLEKYKENEARELEHPILFEGVSDLLEVISNQGGRHFLVS
                     HRNDQVLEILEKTSIAAYFTEVVTSSSGFKRKPNPESMLYLREKYQISSGLVIGDRPI
                     DIEAGQAAGLDTHLFTSIVNLRQVLDI"
     gene            complement(4947..5501)
                     /locus_tag="ACL8AS_000598"
     CDS             complement(4947..5501)
                     /locus_tag="ACL8AS_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1 family glyoxalase III"
                     /protein_id="HGS1228510.1"
                     /translation="MVKVAVMLAQGFEEIEALTVVDVLRRANITCDMVGFEEQVTGSH
                     AIQVRADHVFDGDLSDYDMIVLPGGMPGSAHLRDNQTLIQELQSFEQEGKKLAAICAA
                     PIALNQAEILKNKRYTCYDGVQEQILDGHYVKETVVVDGQLTTSRGPSTALAFAYELV
                     EQLGGDAESLRTGMLYRDVFGKNQ"
     gene            complement(5512..6735)
                     /locus_tag="ACL8AS_000599"
     CDS             complement(5512..6735)
                     /locus_tag="ACL8AS_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HGS1228511.1"
                     /translation="MKRSLDSRVDYSLLLPVFFLLVIGVVAIYIAVSHDYPNNILPIL
                     GQQVAWIALGLVIGFVVMLFNTEFLWKVTPFLYILGLGLMILPIVFYNPSLVASTGAK
                     NWVSINGITLFQPSEFMKISYILMLARVIVQFTKKHKEWRRTVPLDFLLIFWMILFTI
                     PVLVLLALQSDLGTALVFVAIFSGIVLLSGVSWKIIIPVFVTAVTGVAGFLAIFISKD
                     GRAFLHQIGMPTYQINRILAWLNPFEFAQTTTYQQAQGQIAIGSGGLFGQGFNASNLL
                     IPVRESDMIFTVIAEDFGFIGSVLVIALYLMLIYRMLKITLKSNNQFYTYISTGLIMM
                     LLFHIFENIGAVTGLLPLTGIPLPFISQGGSAIISNLIGVGLLLSMSYQTNLAEEKSG
                     KVPFKRKKVVLKQIK"
     gene            complement(6772..9222)
                     /locus_tag="ACL8AS_000600"
     CDS             complement(6772..9222)
                     /locus_tag="ACL8AS_000600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006139 - nucleobase-containing compound
                     metabolic process [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional DnaQ family
                     exonuclease/ATP-dependent helicase"
                     /protein_id="HGS1228512.1"
                     /translation="MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTD
                     VNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIFDLVEDGIFVAHNVQFDANLLAE
                     NLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE
                     LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYF
                     KKTAASLELRKLSQDFSKNISLLNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGK
                     TYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKL
                     DAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLS
                     SHSLFVTEDFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLA
                     LENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNIL
                     DSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSGRTLLSSL
                     LPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTET
                     SLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKK
                     RFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKN
                     AFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIVASLAEEATVK
                     TISRSEVDEAIDRFFNEL"
     gene            complement(9422..10351)
                     /locus_tag="ACL8AS_000601"
     CDS             complement(9422..10351)
                     /locus_tag="ACL8AS_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006154193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase U32 family protein"
                     /protein_id="HGS1228513.1"
                     /translation="MEKIVITATAESIEQVEQLLEAGVDRIYVGEKDFGLRLPTTFSY
                     DQLREIAKLVHDAGKELLVAVNALMHQDMMDRIKPFLDFLEEIKTDYITIGDAGVFYV
                     VNRDGYSFKTIYDASTMVTSSRQINFWGQKAGASEAVLAREIPSAELFKMPEILEIPA
                     EVLVYGASVIHHSKRPLLQNYYNFTHIDDEKTHKRDLFLAEPSDPESHYSIFEDNHGT
                     HIFANNDLDLMIKLTELVEHGFTRWKLEGLYTPGQNFVEIAKLFIQARSLIQEGNFSH
                     DQAFLLDEEVRKLHPKNRFLDTGFYDYDPDMVK"
     gene            10491..10778
                     /locus_tag="ACL8AS_000602"
     CDS             10491..10778
                     /locus_tag="ACL8AS_000602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3270 domain-containing protein"
                     /protein_id="HGS1228514.1"
                     /translation="MPVRKLQSYEVDYQEELNQQLPHYQAYTPEAQSDANLKEILFFI
                     NIAVFCICIAIFSFIFLALKLSTALAFAAAIGFSLLVLKVQRSIIKRKRRR"
     gene            complement(10812..12146)
                     /gene="ciaH"
                     /locus_tag="ACL8AS_000603"
     CDS             complement(10812..12146)
                     /gene="ciaH"
                     /locus_tag="ACL8AS_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000491790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     CiaH"
                     /protein_id="HGS1228515.1"
                     /translation="MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLY
                     TSVDDKLHGLSENPQAVIQLAINRATEEIKDLENARADASKVEIKPNVSSNTEVILFD
                     KDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
                     IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQ
                     SFVENASHELRTPLAVLQNRLETLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLN
                     LARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRIHRTIVTDQLLLKQL
                     MTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKA
                     RTRQKGGFGLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK"
     gene            complement(12136..12810)
                     /gene="ciaR"
                     /locus_tag="ACL8AS_000604"
     CDS             complement(12136..12810)
                     /gene="ciaR"
                     /locus_tag="ACL8AS_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CiaR"
                     /protein_id="HGS1228516.1"
                     /translation="MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGV
                     YDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKP
                     FYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
                     FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGY
                     LLKDVQ"
     gene            complement(12919..15465)
                     /locus_tag="ACL8AS_000605"
     CDS             complement(12919..15465)
                     /locus_tag="ACL8AS_000605"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001149089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004177 - aminopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008237 - metallopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HGS1228517.1"
                     /translation="MQAVEHFIKQFVPEHYDLFLDLSRETKTFSGKVTITGQAQSDRI
                     SLHQKDLEITSVEVAGQARPFTVDHDNEALHIELAEAGQVELVLAFSGKITDNMTGIY
                     PSYYTVDGVKKEVLSTQFESHFAREAFPCVDEPEAKATFDLSLRFDQAEGELALSNMP
                     EIDVENRKETGIWKFETTPRMSSYLLAFFAGDLQGVTAKTKNGTLVGVYSTKAHPLSN
                     LDFSLDIAVRSIEFYEDYYGVKYPIPQSLHIALPDFSAGAMENWGLVTYREVYLVVDE
                     NSTFASRQQVALVVAHELAHQWFGNLVTMKWWDDLWLNESFANMMEYVCVDTIEPSWN
                     IFEDFQTGGVPLALERDATDGVQSVHVEVKHPDEINTLFDGAIVYAKGSRLMHMLRRW
                     LGDADFAKGLHAYFEKHQYSNTIGSDLWDALGQASGRDVAAFMDSWLEQPGYPVLTVK
                     VENDVLKISQKQFFIGENEDKNRLWVVPLNSNWKGLPDTLETESIEIPGYAALLAENE
                     GALRLNTENTAHYITDYQGDLLEAVLAELETLDNTSKLQIVQERRLLAEAGHISYADL
                     LPVLDKLAKEESYLVVSAVSQVISALERFIDEGTDAETAFKGLVAKLARHNYDRLGFE
                     AKDGESDEDELVRQLAVSMMIRSNDAEARQVASQIFATHKENLAELPAAIRSQVLINE
                     MKHHETKDLLALYLDTYTHATDAVFKRQLTAALAYSTDADNIQNLITSWKDKFVVKPQ
                     DLSAWYYQFLAHQATQKTAWSWARENWAWIKAALGGDMSFDSFVILPAHVFKTQQRLA
                     EYKEFFEPQLSDLALSRNIGMGIKEIAARVDLISREKAAVEAVVLQYGNA"
     gene            complement(15588..16028)
                     /locus_tag="ACL8AS_000606"
     CDS             complement(15588..16028)
                     /locus_tag="ACL8AS_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ASCH domain-containing protein"
                     /protein_id="HGS1228518.1"
                     /translation="MIPQEMWNKYKQINPLIGDEIDAWAFGVEPDLLADLVFKGEKTA
                     TASAYDLYVLEDEPLPQVGTFDIILDSQNQSVCIVEITKVSVELFNQVSAQHAFKEGE
                     GDKSLAYWRQVHEDFFTDCLGEVGLTFTSESKVVLEEFRKVYPL"
     gene            complement(16003..16872)
                     /locus_tag="ACL8AS_000607"
     CDS             complement(16003..16872)
                     /locus_tag="ACL8AS_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="putative PEP-binding protein"
                     /protein_id="HGS1228519.1"
                     /translation="MRNQLALSGEKILEKIYPQLFHHVGMIRGEYLLRELNQNIILAS
                     CQQFVKDYLETICSLYSDEEVWYRFTELTNTEANCLVGTKEFFDEGHPLFGYRGTRRL
                     LACLDEFQAEAHVVTEVYQTNPNLSVIFPFANDADQLKQAITALRQYGFTGKVGTMIE
                     LPSAYFDLSSILETGISKIVVGMNDLTSFVFATMRNSQWHDLESPIMLDMLRDMQDKA
                     RKNKINFAVAGYLNTSFIQKMNQLGIKCIIHYSSIPEIFDLEIDHPDHLKHIKEESKK
                     LQRSTHDTARNVE"
     gene            complement(16850..17350)
                     /locus_tag="ACL8AS_000608"
     CDS             complement(16850..17350)
                     /locus_tag="ACL8AS_000608"
                     /EC_number="3.6.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HGS1228520.1"
                     /translation="MEIKKHFGVYAVCLENGKLLCIEKTRGPYQHRYDLPGGSQQLGE
                     GLTETLTREVMEETGFTVRSYSNPRIYDVFVREELTNFMVHHVMALYDVEMNESAPQV
                     TTSEAVSDGANDSLGYIWMDIQEITEENASPLVLKVKSELLGFPELDKTSYMNWKVND
                     EKSTCP"
     gene            complement(17361..18059)
                     /locus_tag="ACL8AS_000609"
     CDS             complement(17361..18059)
                     /locus_tag="ACL8AS_000609"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HGS1228521.1"
                     /translation="MTKRVLITGVSSGIGLAQARLFLEKGYQVYGVDQGEKPLLEGDF
                     HFLQRDLTLDLEPIFDWCPQVDVLCNTAGVLDDYKPLLEQTAQDIQEIFEINYIIPVE
                     LTRYYLTQMLENKKGIIINMCSIASSLAGGGGHAYTSSKHALAGFTKQLALDYAEAGI
                     QVFGIAPGAVKTAMTAADFEPGGLADWVASETPIKRWIEPEEIAELSLFLASGKASAM
                     QGQILTIDGGWSLK"
     gene            complement(18052..18288)
                     /locus_tag="ACL8AS_000610"
     CDS             complement(18052..18288)
                     /locus_tag="ACL8AS_000610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018367459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2829 domain-containing protein"
                     /protein_id="HGS1228522.1"
                     /translation="MTFEEILPGLKAKRKYVRTGWGGAENYVQLFDTIEQNGLALEMT
                     PYFLINVSGEGEGFSMWSPTVCDVLATDWVEVHD"
     gene            complement(18384..19310)
                     /locus_tag="ACL8AS_000611"
     CDS             complement(18384..19310)
                     /locus_tag="ACL8AS_000611"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase family oxidoreductase"
                     /protein_id="HGS1228523.1"
                     /translation="MRYITLGQDDKELSEIVLGMMRIKDKSVKEVEELVETALSVGIN
                     AFDLADIYGRGRCEELLGLVLKNRPDLREKMWIQSKCGIRIEEFTYFDFSKDYIIKSV
                     DGILQRLKIDHLDSLLLHRPDALMESDQVAEAFDLLYKQGKVRDFGVSNQNPMMMELL
                     KKDVKQPLAVNQLQLSAAFTPGFESAFHVNMEDSQAAMRDGSIFEYCQLHDVVIQAWS
                     VLQFGYFKGNFVGNEKFQALNQVLDRLAIKYGVTSSTIAISWILRYPAKMQAVVGTTN
                     PKHLREVSRAANFSLTRKEWYEIYLAAGNNLP"
     gene            complement(19385..20200)
                     /locus_tag="ACL8AS_000612"
     CDS             complement(19385..20200)
                     /locus_tag="ACL8AS_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228524.1"
                     /translation="MKKMKYYEETSALLHEFSEENQKYFEELWESFNLAGFLYDEDYL
                     REQIYLMMLDFSEAERDGMSAEDYLGKNPKKIMKEILKGAPRSSIKESLLTPILVLAV
                     LHYYQLLSDFSKGPLLTVNLLTFLGQLLIFLIGFGLVATILRRSLVQDSPKMKIGTYI
                     VVGTIVLLVVLGYVGMASFIQEGAFYIPAPWDSLSIFTISLVIGIWNWKEAVFRPFVS
                     MIIAHLVVGSLLRYYEWMGISNVFLTKVIPLAVLFIGIFVLFRGFKKIKWSEV"
     gene            complement(20204..20524)
                     /locus_tag="ACL8AS_000613"
     CDS             complement(20204..20524)
                     /locus_tag="ACL8AS_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HGS1228525.1"
                     /translation="MKETQLLKGVLEGCVLDMIGQKERYGYELVQTLREAGFDTIVPG
                     TIYPLLQKLEKNQWIRGDMRPSPDGPDRKYFSLMKEGEERVSVFWQQWDDLSQKVEGI
                     KNGG"
     gene            complement(20614..20895)
                     /locus_tag="ACL8AS_000614"
     CDS             complement(20614..20895)
                     /locus_tag="ACL8AS_000614"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228526.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDRTDEVSSKHVFEVVDETDEVS
                     SKHVFEVVDETDEVSSKHCFEVVDETDEVSNHTYGRATLTWFEEIFEEY"
     gene            complement(20945..22942)
                     /gene="metG"
                     /locus_tag="ACL8AS_000615"
     CDS             complement(20945..22942)
                     /gene="metG"
                     /locus_tag="ACL8AS_000615"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000049 - tRNA binding [Evidence IEA];
                     GO_function: GO:0004825 - methionine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HGS1228527.1"
                     /translation="MSEKNFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGYDV
                     FYLTGLDEHGQKIQQKAEEAGITPQAYVDGMAVGVKELWQLLDISYDKFIRTTDDYHE
                     KVVAQVFERLLAQDDIYLGEYSGWYSVSDEEFFTESQLAEVFRDEAGNVTGGIAPSGH
                     EVEWVSEESYFLRLSKYQDRLVEFFKAHPEFITPDGRLNEMLRNFIEPGLEDLAVSRT
                     TFTWGVPVPSNPKHVVYVWIDALLNYATALGYAQDEHGNFDKFWNGTVFHMVGKDILR
                     FHSIYWPILLMMLDVKLPDRLIAHGWFVMKDGKMSKSKGNVVYPEMLVERYGLDPLRY
                     YLMRNLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVSMINKYFDGQIPAYVEGVT
                     EFDHVLAEVAEQSIADFHTHMEAVDYPRALEAVWTLISRTNKYIDETAPWVLAKDEAL
                     RDQLASVMSHLAASIRVVAHLIEPFMMETSRAVLTQLGLEEVSSLENLSLADFPADVT
                     VVAKGTPIFPRLNMEEEIAYIKEQMEGNKPAVEKEWNPDEVELKLNKDEIKFEDFDKV
                     EIRVAEVKEVSKVEGSDKLLQFRLDAGDGEDRQILSGIAKYYPNEQELVGKKVQIVAN
                     LKPRKMMKKYVSQGMILSAEHDGKLTLLTVDPAVPNGSVIG"
     gene            complement(23066..24325)
                     /locus_tag="ACL8AS_000616"
     CDS             complement(23066..24325)
                     /locus_tag="ACL8AS_000616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228528.1"
                     /translation="MQNLKFAFSSIMAHKMRSLLTMIGIIIGVSSVVVIMALGDSLSR
                     QVNKDMTKSQKNISVFFSPKKSKDGSFTQKQSAFTVSGKEEEVPVEPPKPQESWVQEA
                     AKLKGVDSYYVTNSTNAILTYQDKKVENANLTGGNRTYMDAVKNEIIAGRSLREQDFK
                     EFASVILLDEELSISLFESPQEAINKVVEVNGFSYRVIGVYTSPEAKRSKIYGFGGLP
                     ITTNISLAANFNVDEIANIVFRVNDTSLTPTLGPELARKMTELAGLQQGEYQVADESL
                     VFAEIQQSFSFMTTIISSIAGISLFVGGTGVMNIMLVSVTERTREIGLRKALGATRAN
                     ILIQFLIESMILTLLGGLIGLTIASGLTALAGLLLQGLIEGIEVGVSIPVALFSLAVS
                     ASVGMIFGVLPANKASKLDPIEALRYE"
     gene            complement(24327..25028)
                     /locus_tag="ACL8AS_000617"
     CDS             complement(24327..25028)
                     /locus_tag="ACL8AS_000617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228529.1"
                     /translation="MKQLISLKNIFRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSG
                     SGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEKQLAKVRNQQIGFVFQQFFLLSKLN
                     ALQNVELPLIYAGVSSSKRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARALV
                     NNPSIILADEPTGALDTKTGNQIMQLLVDLNKEGKTIIMVTHEPEIAAYAKRQIVIRD
                     GVISSDSAQLGKEEN"
     gene            complement(25012..26211)
                     /locus_tag="ACL8AS_000618"
     CDS             complement(25012..26211)
                     /locus_tag="ACL8AS_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_function: GO:0042802 - identical protein binding
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HGS1228530.1"
                     /translation="MKKKNGKAKKWQLYAAIGAASVVVLGAGGILLFRQPSQTALKDE
                     PTHLVVANEGSVASSVLLSGTVTAKNEQYVYFDASKGDLDEILVSVGDKVSEGQALVK
                     YSSSEAQAAYDSASRAVAKADRHINELNQARNEAASAQAPQLPAPVGGEDATVQSPTP
                     VAGNSVASIDAQLGDARDARADAAAQLSKAQSQLDATTVLSTLEGTVVEVNSNVSKSP
                     TGASQVMVHIVSNENLQVKGELSEYNLANLSVGQEVSFTSKVYPDKKWTGKLSYISDY
                     PKNNGEAASPAAGNNTGSKYPYTIDVTGEVGDLKQGFSVNIEVKSKTKAILVPVSSLV
                     MDDSKNYVWIVDEQQKAKKVEVSLGNADAENQEITSGLTNGAKVISNPTSSLEEGKEV
                     KADEATN"
     gene            26497..27843
                     /gene="gor"
                     /locus_tag="ACL8AS_000619"
     CDS             26497..27843
                     /gene="gor"
                     /locus_tag="ACL8AS_000619"
                     /EC_number="1.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004362 - glutathione-disulfide reductase
                     (NADPH) activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0006749 - glutathione metabolic process
                     [Evidence IEA];
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-disulfide reductase"
                     /protein_id="HGS1228531.1"
                     /translation="MREYDIIAIGGGSGGIATMNRAGEHGAKAAVIEEKKLGGTCVNV
                     GCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFNFATLRRNREAYIDRARSSYDGSF
                     KRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
                     AWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEME
                     RTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVT
                     LNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDY
                     STIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLI
                     TAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTSSEEFVTMR"
     gene            28039..28575
                     /locus_tag="ACL8AS_000620"
     CDS             28039..28575
                     /locus_tag="ACL8AS_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000709035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HGS1228532.1"
                     /translation="MKKAHVYAIPAIGAALIAVLAQISLPIGPVPFTLQNFAIGLIAT
                     VFRPREAVLSAGLYLLLGAIGLPVFAGGGAGFQALVGPTAGYLWFYLVYSGLTSSLTN
                     SKSGVVKIFLANLLGDALVFVGGILSLHFLAGMAFEKALVVGVLPFIIPDLGKLLAIS
                     FISRPLLQRLKNQTYFTN"
     gene            28637..28783
                     /locus_tag="ACL8AS_000621"
     CDS             28637..28783
                     /locus_tag="ACL8AS_000621"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228533.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDETDEVSNHTYGKAKLMRFEEI
                     FEEY"
     gene            complement(28780..28995)
                     /locus_tag="ACL8AS_000622"
     CDS             complement(28780..28995)
                     /locus_tag="ACL8AS_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdbC family protein"
                     /protein_id="HGS1228534.1"
                     /translation="MAEFTFEIEEHLLTLSENEKGWTKEINRVSFNGAPAKFDIRAWS
                     PDHTKMGKGITLSNEEFQTMVDAFKGN"
     gene            29093..29413
                     /locus_tag="ACL8AS_000623"
     CDS             29093..29413
                     /locus_tag="ACL8AS_000623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001216095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228535.1"
                     /translation="MRHKFQQVLDKIHDFLNGHDQPDQTETNSLTATIEEAIQKQTAV
                     HLILSETSFTGDIIKYDQQGQQIIVKNFSKNVSRIIRISDIQRLRFVPSTVQTAQKNR
                     FKKE"
     gene            complement(29443..29781)
                     /locus_tag="ACL8AS_000624"
     CDS             complement(29443..29781)
                     /locus_tag="ACL8AS_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP cone domain-containing protein"
                     /protein_id="HGS1228536.1"
                     /translation="MQVIKRNGEIAEFNPDKIYQAILKAAQTVYVLTDDLRQNLAQVT
                     KKVVLDLQEAKVERATISMIQSMVEHRLLGAGYITIAEHYISYRLQRDLERSGYGDHI
                     AVHLHFEQIR"
     gene            complement(29793..30512)
                     /gene="trmD"
                     /locus_tag="ACL8AS_000625"
     CDS             complement(29793..30512)
                     /gene="trmD"
                     /locus_tag="ACL8AS_000625"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052906 - tRNA
                     (guanine(37)-N1)-methyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HGS1228537.1"
                     /translation="MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKA
                     RHVDDEPYGGGQGMLLRAQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEE
                     LIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSH
                     QDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLL
                     EHYQLTVEEEKMLAEIKENKE"
     gene            complement(30502..31020)
                     /gene="rimM"
                     /locus_tag="ACL8AS_000626"
     CDS             complement(30502..31020)
                     /gene="rimM"
                     /locus_tag="ACL8AS_000626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465641.1"
                     /note="Essential for efficient processing of 16S rRNA;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimM"
                     /protein_id="HGS1228538.1"
                     /translation="MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELALFDEK
                     DQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYH
                     EIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRV
                     DVEILEGLDDED"
     gene            complement(31051..31839)
                     /locus_tag="ACL8AS_000627"
     CDS             complement(31051..31839)
                     /locus_tag="ACL8AS_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HGS1228539.1"
                     /translation="MKRFEVSTEIGSLSVAYQKQKKVLVCLNGAGLLPSYENFSLILE
                     KPPPTIGYLTIDFPNTGRSPIYDQAGKNLDNLADVVYEALEELGISEYILCVHSWSGI
                     LACKLLEKPIKCQTLVAIEPTTKKVMFADFSENPYPEMEEQMRLIDECGPELYFKNLT
                     QATFSPETNKKIWELMQEKGLELENQDPEFQISGEITEEDFENLSIESHVPIFIFCQT
                     YREKEYRESEYWTSNTKLILGGNHHYLQWSESEKIAAIIRELSE"
     gene            complement(31943..32267)
                     /locus_tag="ACL8AS_000628"
                     /pseudo
     CDS             complement(31943..32267)
                     /locus_tag="ACL8AS_000628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000654120.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MazG nucleotide pyrophosphohydrolase
                     domain-containing protein"
     gene            complement(32416..32655)
                     /gene="kphA"
                     /locus_tag="ACL8AS_000629"
     CDS             complement(32416..32655)
                     /gene="kphA"
                     /locus_tag="ACL8AS_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein KphA"
                     /protein_id="HGS1228540.1"
                     /translation="MDTIENLIIAIVKPLISQPDALTIKIEDTPEFLEYHLNLDQSDV
                     GRVIGRKGRTISAIRTIVYSVPTEYKKVRIVIDEK"
     gene            complement(32675..32947)
                     /gene="rpsP"
                     /locus_tag="ACL8AS_000630"
     CDS             complement(32675..32947)
                     /gene="rpsP"
                     /locus_tag="ACL8AS_000630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HGS1228541.1"
                     /translation="MAVKIRLTRMGSKKKPFYRINVADSRSPRDGRFIETVGTYNPLV
                     AENQVTLKEDRVLTWLANGAQPSDTVRNILSKEGVLKKFHDSKFSK"
     gene            33117..33326
                     /locus_tag="ACL8AS_000631"
     CDS             33117..33326
                     /locus_tag="ACL8AS_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000953868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228542.1"
                     /translation="MLSVNTILEKFYKEHQVKPFISPERDLDTWLLSPKPVPKRNMDL
                     LVDDSLAGDIILLWRIQFGTFTTET"
     gene            33805..33996
                     /locus_tag="ACL8AS_000632"
     CDS             33805..33996
                     /locus_tag="ACL8AS_000632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000011698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228543.1"
                     /translation="MSFYGLFYNGIAITPNTYLSAWFVNFIAALPLNFLIVEPIARFI
                     LSSFQKPFTGEEVEEVEDF"
     gene            34110..34913
                     /locus_tag="ACL8AS_000633"
     CDS             34110..34913
                     /locus_tag="ACL8AS_000633"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA];
                     GO_process: GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HGS1228544.1"
                     /translation="MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVA
                     AQSAKELNDALTNENANFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFL
                     THAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
                     LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLD
                     GKHPVFGQVIGGMDVVDKIAKAEKDEKDKPTTAITIDSIEVVKDYDFKS"
     gene            complement(34970..36511)
                     /locus_tag="ACL8AS_000634"
     CDS             complement(34970..36511)
                     /locus_tag="ACL8AS_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002918612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HGS1228545.1"
                     /translation="MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKST
                     FMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLAERQSVRDVLRTAFDELFKAEARIN
                     DLYMKMAEDGADVDALMEEVGELQDRLESRDFYTLDAKIDEVARALGIMDFGMDTDVT
                     SLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDI
                     PFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVA
                     RNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGY
                     DRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFE
                     QEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRF
                     CLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHDPDFYEGWIDQIWD
                     FNNLT"
     gene            complement(36513..36995)
                     /locus_tag="ACL8AS_000635"
     CDS             complement(36513..36995)
                     /locus_tag="ACL8AS_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000976721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HGS1228546.1"
                     /translation="MVKKTYNHILVWGVIFYSICIVCFCFTPQEQSTVGVGTPGIQHL
                     GRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNILNVFLFFPLIFQLLYLFPNLRKTKK
                     VLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKVRN
                     "
     gene            complement(36995..38080)
                     /gene="rlmN"
                     /locus_tag="ACL8AS_000636"
     CDS             complement(36995..38080)
                     /gene="rlmN"
                     /locus_tag="ACL8AS_000636"
                     /EC_number="2.1.1.192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000804770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0030488 - tRNA methylation [Evidence IEA];
                     GO_process: GO:0070475 - rRNA base methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HGS1228547.1"
                     /translation="MKPSIHSLAHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEE
                     MTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMCQHYGLS
                     VCVTTQVGCNIGCTFCSSGLIKKQRDLNNGEIVAQIMLVQKYFDERGQDERVSHIVVM
                     GIGEPFDNYNNVLNFFRTINDDKGMAIGARHITVSTSGLAHKIRDFADEGVQVNLAVS
                     LHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDGVEQALE
                     LTELLKNIKKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGVNCVVRQEHGT
                     DIDAACGQLRSNTMKRDRQKAVAAVNP"
     gene            complement(38101..38631)
                     /locus_tag="ACL8AS_000637"
     CDS             complement(38101..38631)
                     /locus_tag="ACL8AS_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YutD family protein"
                     /protein_id="HGS1228548.1"
                     /translation="MRKEIAPELYNYNKFPGPEFHLHGDKVETEGIAFSLVENIKDAF
                     DVTTFNQRFSEVLTKFDYIVGDWSNEQLRLRGFYKDDRTEEKLEKISRLQDYLLEYCS
                     YGCAYFVLENEAPKRASFDKKMRKTEEETPSRKGKKPTQTKRKSNADKKNRRRQKDQH
                     SQKEDKEQRHFVIRQK"
     gene            complement(38788..39393)
                     /gene="sodA"
                     /locus_tag="ACL8AS_000638"
     CDS             complement(38788..39393)
                     /gene="sodA"
                     /locus_tag="ACL8AS_000638"
                     /EC_number="1.15.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase SodA"
                     /protein_id="HGS1228549.1"
                     /translation="MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALE
                     KHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAA
                     IDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL
                     GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK"
     gene            complement(39566..40603)
                     /gene="holA"
                     /locus_tag="ACL8AS_000639"
     CDS             complement(39566..40603)
                     /gene="holA"
                     /locus_tag="ACL8AS_000639"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HGS1228550.1"
                     /translation="MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDS
                     ADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSF
                     EEYLDNPSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
                     QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKADSVIEEEDIVNVIPKTLQDNIF
                     DLTQFILTKKMDQARDLVRDLTLQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQI
                     ASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFE
                     KALLQIASQVN"
     gene            complement(40637..41572)
                     /locus_tag="ACL8AS_000640"
     CDS             complement(40637..41572)
                     /locus_tag="ACL8AS_000640"
                     /EC_number="1.3.98.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004152 - dihydroorotate dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate oxidase"
                     /protein_id="HGS1228551.1"
                     /translation="MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVT
                     KTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLV
                     GMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
                     PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGI
                     GGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKE
                     GVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID"
     gene            complement(42125..43315)
                     /gene="metK"
                     /locus_tag="ACL8AS_000641"
     CDS             complement(42125..43315)
                     /gene="metK"
                     /locus_tag="ACL8AS_000641"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004478 - methionine adenosyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006556 - S-adenosylmethionine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HGS1228552.1"
                     /translation="MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAE
                     TAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSP
                     DIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRL
                     AELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDK
                     VIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFS
                     GKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVA
                     ESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALK
                     EAVK"
     gene            complement(43692..45035)
                     /locus_tag="ACL8AS_000642"
     CDS             complement(43692..45035)
                     /locus_tag="ACL8AS_000642"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HGS1228553.1"
                     /translation="MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGE
                     SKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRV
                     VNYVGGTDKARQIEKLASNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLD
                     MGFLEIVDKIAGSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTID
                     NWLISTKGHDKNAQIYQLTQLMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDI
                     APRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTG
                     RNGLPGTAITLYQPSDDSDIRELEKLGIKFSPKMVKDGEFQDTYDRDRRANREKKQDK
                     LDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRAERKAKRQTF"
     gene            complement(45175..45990)
                     /locus_tag="ACL8AS_000643"
     CDS             complement(45175..45990)
                     /locus_tag="ACL8AS_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HGS1228554.1"
                     /translation="MKFLTLNTHSWMEKEAEEKFQILLEDILEKDYDLICFQEINQEM
                     TSSEVEVNDLYQALPAAEPIHQDHYVRLLVEKLLEQGKNYYWTWAYNHIGYDRYHEGV
                     AILSKTPIEAREILVSDVDDPTDYHTRRVALAETVVDGKELAVASVHLSWWDKGFQEE
                     WARFEAVLKKLNKPLLLAGDFNNPAGQEGYQAILASPLGLQDAFEVAQEKSGSYTVPP
                     EIDGWKENTEPLRIDYVFTTKELAVENLHVVFDGNKSPQVSDHYGLNAILNWK"
     gene            complement(46042..48222)
                     /locus_tag="ACL8AS_000644"
     CDS             complement(46042..48222)
                     /locus_tag="ACL8AS_000644"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000974069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015144 - carbohydrate transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIBC"
                     /protein_id="HGS1228555.1"
                     /translation="MMKDTFKNVLSFEFWQKFGKALMVVIAVMPAAGLMISIGKSIVM
                     INPTFTPLVITGGILEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINR
                     ITGTIFGVSGDMLKNPDAMVTTFFGGSIKVADYFISVLEAPALNMGVFVGIISGFVGA
                     TAYNKYYNFRKLPDALSFFNGKRFVPFVVILRSAIAAILLAAFWPVVQTGINNFGIWI
                     ANSQETAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYDILTGAAKGTQVFG
                     QDPLWLAWVTDLVNLKGTDASQYQHLLDTVHPARFKVGQMIGSFGILMGVIVAIYRNV
                     DADKKHKYKGMMIATALATFLTGVTEPIEYMFMFIATPMYLVYSLVQGAAFAMADVVN
                     LRMHSFGSIEFLTRTPIAISAGIGMDIVNFVWVTVLFAVIMYFIANFMIQKFNYATPG
                     RNGNYETAEGSEETSSEVKVAAGSQAVNIINLLGGRVNIVDVDACMTRLRVTVKDADK
                     VGNAEQWKAEGAMGLVMKGQGVQAIYGPKADILKSDIQDILDSGEIIPETLPSQMTEA
                     QQNTVHFKDLTEEVYSVADGQVVALEQVKDPVFAQKMMGDGFAVEPANGNIVSPVSGT
                     VSSIFPTKHAFGIVTEAGLEVLVHIGLDTVSLEGKPFTVHVAEGQKVAAGDLLVTADL
                     DAIRAAGRETSTVVVFTNGDAIKSVKLEKTGSLAAKTAVAKVEL"
     gene            complement(48508..49434)
                     /gene="ftsX"
                     /locus_tag="ACL8AS_000645"
     CDS             complement(48508..49434)
                     /gene="ftsX"
                     /locus_tag="ACL8AS_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="permease-like cell division protein FtsX"
                     /protein_id="HGS1228556.1"
                     /translation="MISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVI
                     FNTAKLATDIENNVRVVVYIRKDVEDNSQTIEKEGQTVTNNDYHKVYDSLKNMSTVKS
                     VTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANAPNDVKTIAEDAKKIEGV
                     SEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMR
                     LVGAKNSYIRGPFLLEGAFIGLLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPD
                     LFSPLMIALLFVIGVFIGSLGSGISMRRFLKI"
     gene            complement(49427..50119)
                     /gene="ftsE"
                     /locus_tag="ACL8AS_000646"
     CDS             complement(49427..50119)
                     /gene="ftsE"
                     /locus_tag="ACL8AS_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="HGS1228557.1"
                     /translation="MSIIEMRDVVKKYDNGTTALRGVSVSVQPGEFAYIVGPSGAGKS
                     TFIRSLYREVKIDKGSLSVAGFNLVKIKKKDVPLLRRSVGVVFQDYKLLPKKTVYENI
                     AYAMEVIGENRRNIKKRVMEVLDLVGLKHKVRSFPNELSGGEQQRIAIARAIVNNPKV
                     LIADEPTGNLDPDNSWEIMNLLERINLQGTTILMATHNSQIVNTLRHRVIAIENGRVV
                     RDESKGEYGYDD"
     gene            complement(50137..51232)
                     /gene="prfB"
                     /locus_tag="ACL8AS_000647"
     CDS             complement(join(50137..51159,51161..51232))
                     /gene="prfB"
                     /locus_tag="ACL8AS_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511312.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0016149 - translation release factor
                     activity, codon specific [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HGS1228558.1"
                     /translation="MDISVIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPD
                     FWNDNIAAQKTSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAE
                     LDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKV
                     EVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVE
                     VMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRT
                     QYGNRDRAMKMLQAKLYQMEQDKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDH
                     RTSFEVAQVDKVMDGDLDGFIDAYLKWRIS"
     gene            complement(51340..51996)
                     /locus_tag="ACL8AS_000648"
     CDS             complement(51340..51996)
                     /locus_tag="ACL8AS_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HGS1228559.1"
                     /translation="MAVKDFMTRKVVYISPDTTVSHAADLMREQGLHRLPVIENDQLV
                     GLVTEGTIAQASPSKATSLSIYEMNYLLNKTKVKDVMIRDVVTVSGYASLEDATYLML
                     KNKISILPVVDNHQVYGVITDRDVFQAFLEIAGYGEEGIRVRFVTEDEVGVLGKIVSL
                     IVEENLNISHTVNIPRKDGKVIIEVQIDGSIDLPALKEKFEANGIQVEEIARTSAKVL
                     "
     gene            complement(52304..53014)
                     /locus_tag="ACL8AS_000649"
     CDS             complement(52304..53014)
                     /locus_tag="ACL8AS_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000062217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228560.1"
                     /translation="MSMLKVENLSVHYGMIQAVRDVSFEVNKGEVVSLIGANGAGKTT
                     ILRTLSGLVRPSSGKIEFLGQEIQKMPAQKIVAGGLSQVPEGRHVFPGLTVMENLEMG
                     AFLKKNREENQANLKKVFSRFPRLEERKNQDAATLSGGEQQMLAMGRALMSTPKLLLL
                     DEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNANKALAISDRGYVLETGKIVLSG
                     TGKELASSEEVRKAYLGG"
     gene            complement(53014..53778)
                     /locus_tag="ACL8AS_000650"
     CDS             complement(53014..53778)
                     /locus_tag="ACL8AS_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228561.1"
                     /translation="MALLEVKQLTKHFGGLTAVGDVTLELNEGELVGLIGPNGAGKTT
                     LFNLLTGVYEPSEGTVTLDGHLLNGKSPYKIASLGLGRTFQNIRLFKDLTVLDNVLIA
                     FGNHHKQHVFTSFLRLPAFYKSEKELKAKALELLKIFDLDGDAETLAKNLSYGQQRRL
                     EIVRALATEPKILFLDEPAAGMNPQETAELTELIRRIKDEFKITIMLIEHDMNLVMEV
                     TERIYVLEYGRLIAQGTPDEIKTNKRVIEAYLGGEA"
     gene            complement(53778..54734)
                     /locus_tag="ACL8AS_000651"
     CDS             complement(53778..54734)
                     /locus_tag="ACL8AS_000651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HGS1228562.1"
                     /translation="MKENLKVNILWLLLLLAGYSLISVLVSVGVLNLFYVQILQQIGI
                     NIILAVGLNLIVGFSGQFSLGHAGFMAIGAYAAAIIGSTSPTYGAFFGAMLVGALLSG
                     VVALLVGIPTLRLKGDYLAVATLGVSEIIRIFIINGGSLTNGAAGILGIPNFTTWQMV
                     YFFVVITTIATLNFLRSPIGRSTLSVREDEIAAESVGVNTTKIKIIAFVFGAITASIA
                     GSLQAGFIGSVVPKDYTFINSINVLIIVVFGGLGSITGAIVSAIVLGILNMLLQDVAS
                     VRMIIYALALVLVMIFRPGGLLGTWELSLSRFFKKSKKEEQN"
     gene            complement(54738..55607)
                     /locus_tag="ACL8AS_000652"
     CDS             complement(54738..55607)
                     /locus_tag="ACL8AS_000652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HGS1228563.1"
                     /translation="MLQQLVNGLILGSVYALLALGYTMVYGIIKLINFAHGDIYMMGA
                     FIGYFLINSFQMNFFVALIVAMLATAILGVVIEFLAYRPLRHSTRIAVLITAIGVSFL
                     LEYGMVYLVGANTRAFPQAIQTVRYDLGPISLTNVQLMILAISLILMILLQVIVQKTK
                     MGKAMRAVSVDSDAAQLMGINVNRTISFTFALGSALAGAAGVLIALYYNSLEPLMGVT
                     PGLKSFVAAVLGGIGIIPGAALGGFVIGLLETFATAFGMSDFRDAIVYGILLLILIVR
                     PAGILGKNVKEKV"
     gene            complement(55875..57035)
                     /locus_tag="ACL8AS_000653"
     CDS             complement(55875..57035)
                     /locus_tag="ACL8AS_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1228564.1"
                     /translation="MKKKFALSFVALASVALLAACGEVKSGAVNTAGNSVEEKTIKIG
                     FNFEESGSLAAYGTAEQKGAQLAVDEINAAGGIDGKQIEVVDKDNKSETAEAASVTTN
                     LVTQSKVSAVVGPATSGATAAAVANATKAGVPLLSPSATQDGLTKGQDYLFIGTFQDS
                     FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYKGEIVADETFVAGDTDF
                     QAALTKMKGKDFDAIVVPGYYNEAGKIVNQARGMGIDKPIVGGDGFNGEEFVQQATAE
                     KASNIYFISGFSTTVEVSAKAKAFLDAYRAKYNEEPSTFAALAYDSVHLVANAAKGAK
                     NSGEIKDNLAKTKDFEGVTGQTSFDADHNTVKTAYMMTMNNGKVEAAEVVKP"
     gene            complement(57136..57384)
                     /locus_tag="ACL8AS_000654"
     CDS             complement(57136..57384)
                     /locus_tag="ACL8AS_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbG family protein"
                     /protein_id="HGS1228565.1"
                     /translation="MFEKVNRSGLIIYLYYNRDAKKLQDYGDITYHSKKHRYLQLYVP
                     TQEVEQLVGRLSKEKFIKKVRVCHIQELETPFVGNLYR"
     gene            complement(57463..58053)
                     /gene="clpP"
                     /locus_tag="ACL8AS_000655"
     CDS             complement(57463..58053)
                     /gene="clpP"
                     /locus_tag="ACL8AS_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit
                     ClpP"
                     /protein_id="HGS1228566.1"
                     /translation="MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIA
                     QLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIA
                     SSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
                     SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN"
     gene            complement(58227..58856)
                     /gene="upp"
                     /locus_tag="ACL8AS_000656"
     CDS             complement(58227..58856)
                     /gene="upp"
                     /locus_tag="ACL8AS_000656"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004845 - uracil phosphoribosyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HGS1228567.1"
                     /translation="MGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEV
                     LRDLPLEDVEIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGM
                     YRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCL
                     VSAPEGVKVLQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK"
     gene            complement(58945..59412)
                     /locus_tag="ACL8AS_000657"
     CDS             complement(58945..59412)
                     /locus_tag="ACL8AS_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000138511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HGS1228568.1"
                     /translation="MTEKRLAWDEYFAAQALLIANRSTCKRAKVGAILVKDNKVISTG
                     YNGSVSGTEHCIDHECLVIEGHCVRTLHAEVNAILQGAERGVPKGFTAYVTHFPCLNC
                     TKQLLQVGCKRVVYINQYRMDDYAQYLYQEKGTELTHLPLETVQTALKEADLM"
     gene            complement(59431..59988)
                     /locus_tag="ACL8AS_000658"
     CDS             complement(59431..59988)
                     /locus_tag="ACL8AS_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HGS1228569.1"
                     /translation="MSERRISEKSLENLRKSNQESNLLTREAIETALLQLLEKKELTK
                     ISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLHHYDLKTDLYLVWVH
                     LFRETRKEARVIQLALDYHLEKIFVQAMQEFLEKYHGKSKGVSSYLHSFWSSAIVSVL
                     LKWIKDGMKVPAEKIADLGLPFFKK"
     gene            60113..60958
                     /locus_tag="ACL8AS_000659"
     CDS             60113..60958
                     /locus_tag="ACL8AS_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HGS1228570.1"
                     /translation="MTWKIIADSGCDYRQLPTPAINTTFVSVPLTIQVADQVFVDDAS
                     LDIDQMMETMYATAEASKSACPSPDDYLRAFEGAKNIFLVTITGTLSGSHNSAQLAKN
                     IYLEDHPDTKIHVIDSLSAGGEVDLLVEKLNDLIDQGLSFEEVVEAITAYQEKTKLLF
                     VLAKVDNLVKNGRLSKLIGTVVGLLNIRMVGKASETGTLELLQKARGSKKSVQAAYDE
                     LVKAGYAGGRIVMAQRNNEKCCQQLSERIRETFPQADIKILPTSGLCSFYAEEGGLLM
                     GYEID"
     gene            61017..62192
                     /locus_tag="ACL8AS_000660"
     CDS             61017..62192
                     /locus_tag="ACL8AS_000660"
                     /EC_number="1.14.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HGS1228571.1"
                     /translation="MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAG
                     TGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGR
                     VFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIV
                     TTGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFPHKALQGISLDDVTLSY
                     GKHVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKS
                     LKNALKTLLPERLAEFFVQGYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFV
                     TKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGSLHYD"
     gene            62212..62667
                     /locus_tag="ACL8AS_000661"
     CDS             62212..62667
                     /locus_tag="ACL8AS_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HGS1228572.1"
                     /translation="MNRREAVEFVNMCMIKNGDKVLVQDRVSPDWPGITFPGGHVERG
                     ESFVDAVIREVKEETGLIISKPQLCGIKNWYDDKDYRYVVLFYKTEHFTGELQSSDEG
                     KVWWEDFENLSHLKLATDDMSDMLRVFLEEDLSEFFYYKNGDDWLYDLK"
     gene            complement(62687..63436)
                     /locus_tag="ACL8AS_000662"
     CDS             complement(62687..63436)
                     /locus_tag="ACL8AS_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000274794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HGS1228573.1"
                     /translation="MYHIKETAQLSGVSVKTLHHYDKIGLLVPLKSENGYRTYSQEDL
                     ERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKT
                     IQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHEDEATAAF
                     NQVFQTLAQNLQVGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKDYVYNPEF
                     KENIDKFGSGTAQYTSDAIAAYVQTNAEKIG"
     gene            63541..65019
                     /locus_tag="ACL8AS_000663"
     CDS             63541..65019
                     /locus_tag="ACL8AS_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-dependent transporter"
                     /protein_id="HGS1228574.1"
                     /translation="MIFLTDLRKHDRIVKSINQTEGYLTTQVAFSYFEKGDQSLTMSE
                     KSQWGSKLGFILASAGSVIGLGSVWKFPYMTAANGGGGFLLIFLISTILIGFPLLLAE
                     FALGRSAGVSAIKTFGKLGKNNKYNFIGWIGAFALFILLSFYSVIGGWILVYLGIEFG
                     KLFQLGGTGDYAQLFTSIISNPAIALVAQAAFILLNIFIVSRGVQKGIERASKVMMPL
                     LFIIFVVIIGRSLSLPNAMEGVLYFLKPDFSKLTSAGPLYALGQSFFALSLGVTVMLT
                     YASYLDKKTNLVQSGISIVAMNISISIMAGLAIFQARSPFRLDIEGGPSLLFIVLPQL
                     FDKMPFGTIFYVLFLFATVTSSVVMLEINVGNITNQDNSKRAKWSVILGILTFVFGIP
                     SALSYGVMADVHIFGKIFFDAMDFLASNLLMPFGALYLSLFTGYIFKKALAMEELHLD
                     ERAWKQGLFQVWLFLLRFFVSSFQSSSLWSSLPNLCNQKGLE"
     gene            complement(65040..65984)
                     /gene="manA"
                     /locus_tag="ACL8AS_000664"
     CDS             complement(65040..65984)
                     /gene="manA"
                     /locus_tag="ACL8AS_000664"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004476 - mannose-6-phosphate isomerase
                     activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HGS1228575.1"
                     /translation="MSEPLFLQSVMQEKIWGGAKLRDEFGYDIPSEKIGEYWAISAHP
                     NGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAY
                     GLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAG
                     DFFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNI
                     GEPANSRPVTVKADDLRSTLLVSNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQL
                     TVDGKNYPIQKGRHFILPSDVEAWTLEGQGLELIVSHP"
     gene            complement(66116..66421)
                     /locus_tag="ACL8AS_000665"
                     /pseudo
     CDS             complement(66116..66421)
                     /locus_tag="ACL8AS_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884744.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
BASE COUNT        19684 a        14538 c        12215 g        20388 t
ORIGIN      
        1 tatataatac ttttttattt tagtctagta taaatagcga gaaatatcta tcctatcttc
       61 tagaatgtct tccaaacgag aaaactctcg taaacaaaga ggttttagag gcctatttac
      121 cgtgggacta aagttgtaca agaaaagtgc aaataagaaa tctccagatt aggaactatc
      181 cgtgagttct ctagtctgga gatttttcaa tagacttcgt tattggacgg ttaccaagtt
      241 actcaaagta cagatttgaa gctgcagata agactgacga aatcacttta atactaaatg
      301 aaaatcaaaa agcaaactaa gaagctagcc tcaggctgta cttgagtacg gtaaggcgac
      361 gctgacgtga tttgaagaga ttttcgaaga gtataaaaca ctgttttgag gtggtggata
      421 aatcggctgg gtaaaaactc aatctcagga gaaaatgaag taaatctccc cacaactata
      481 gaaaaagatt tgattctgct cctcacacaa taaaatcttt ttcttttatt aaaaacgaat
      541 cgtttcacgt gttttctcat atgaggtaac aaagcgattg gttacaccag gctctgccac
      601 ttccaatgct tgagaaatct tgtcaaatga agcgtgataa tcaaattctt tttcaaaaat
      661 atctaaagct tcgttaaatg cttcttgaat gcgttcatca aatgagcgat agcggttaga
      721 atattgcaag agttgctctg tcaaagttgc atattgtaca atattataag tttccgtttc
      781 taaagcttcc atatcattcg ttgcaatttc aagaactcgg gtaacagatt caatgttaat
      841 cattttttgt tctaactcaa ccattaaatc ctcggtatta ttgcttgccg taaagaataa
      901 cttcaagaaa gtttgtggaa tacctggcag attgcgtttt tccatgtatc gcttgatagt
      961 atggagacga ttgacataaa cattggcctt ttgacgtgca ttaatatcat ctttctcaat
     1021 ttgtgtcagg cgctcactaa ctgaaatttg ctcatcttca atatctttta gttgagtttg
     1081 taaatcctca agattttctt caagaactga ataagcttgg gttggttctt cttgattcga
     1141 agttacctca acaatagctg cctcaaaact ctctaattct gtctgaatac gacgaacatg
     1201 gcttgcagct gtctcaggaa gtaaataggt cttgttcaaa cgtgcaatat cttctcccaa
     1261 taaagtatta ttctctttca tatgttgaag gtaagttgga agagttgcaa gtagattttc
     1321 cactactttc tgagcagcaa tttctcgagt aaaaatatca tacaaggcat tgatttcctc
     1381 ttgtgcctgt ccattctcat attcggcatt atccaattcc aactgacgaa tattctcttg
     1441 gtttttcttg aatgcttcat aaagcaagtg gaaacgcgct tcaatatccg tttcaacaaa
     1501 atgataatta gcatcaatta gtttacgata accggcttcc aaatcctgta attgatctgg
     1561 caattctgta gaaagcgtcg taaccaaggc tggaacacga tccacaatat gacttaaggc
     1621 caaaatgtga ttttctgtat tatccaaaat cactgcggct tccacagggt cacccgatga
     1681 attcaaggtt acaaattgtg aaaattcaga ttggatattt tctaattgtt tttcaatttc
     1741 atccaaggct tgaccatact gttctgaatt ttcagcaact ctatgctgaa gttcctcaaa
     1801 taaatccaaa gcatgaagaa cacgaccact atttttagat tcttgcttct ctaagtctgc
     1861 caaagcattg cgaattgccg caatatcttc ttcaatcaaa gtaatttgac tctcaatttg
     1921 gtcaatttga tgactggcct tgagaaaacg aaatgaatgg ttatagcctt ctgcttcaaa
     1981 gagattattt tcaatatcgg caaaagagtt gagagataaa tcgacccatt tttgattcca
     2041 ttcacggaaa gccacttgac tttgtccaat caagtgcata ttttttacag cttctacttc
     2101 atcatttact ggaagattgt atagttcttc ttttctttct tctagcgcct ctaatctccc
     2161 ctcgtttcgc ttacgtagaa agattgccac tacataagcc agaactaaaa tgactgcaat
     2221 tgcaaccatt aaataaatta gttgtccatt agacatatca aactcctttt ttacttgaaa
     2281 caatcgtaac gattatatca tattttttag accaagggaa ctacttctcc ctatttttta
     2341 gacatcaagt gtactataga cagcattttc ttcgataaac tcacgacgag gctctactcg
     2401 atcccccatc aacatatcaa agattttatc tgcttctgca gcatcatcta cagaaactct
     2461 agccatcaag cgatgttcgg gatccatggt tgtttcccac agctgatgat cgtccatttc
     2521 acctagcccc ttataacgct gaatagtcgg tttggtacga ccttcactat aacgggctaa
     2581 agcttcttgg agtttgattt cttgatctgc acccggctgg atatattctt taatctcgct
     2641 tccaaccttg acaccataga ttggtggttg ggcaatataa acataaccag cttctaggat
     2701 tggtttcata taacgataaa tcaaggttaa aagaagggta cgaatgtggg ctccatcgac
     2761 atcggcatcg gtcatcaaaa cgagtttttg gtaacgggct ttcgaaacat caaattctgc
     2821 gccaaatcct gttcccatgg ctgtgaaaag actacgaatt tcttcgttag ctagaatctt
     2881 atccatactt gctttttcaa cgttcaaaat cttaccgcga attggaagga tagcctgaaa
     2941 ctcacggtta cgaccagatt tggctgatcc accagctgag tctccttcga cgatgaagag
     3001 ttctgtttca gcagggttat tagaagaaca gtctgctagt ttccctggaa ggttggaaat
     3061 ttccaaacca gattttttac gtgtgacttc acgcgcacgc ttggcagcca cacgagcctt
     3121 ggcagctaaa atcccttttt ccacgatacg tttggcaatc tgtggatttt ccatgaggaa
     3181 atcggagaag gcttcactga agaggcgatt ggtaatcttg accacttcgc tatttcccaa
     3241 tttggtcttg gtttgtcctt caaactgtgg atttgggtgt ttaactgaga taactgcagt
     3301 taagccttcg cgaacatctt cccctgttag gttgtcttca ttgtctttca gtaacttatt
     3361 tttacgagca taatcattga taacacgtgt caaggctgta cggaaacctt gttcatgcgt
     3421 tccaccttca tgtgtatgaa tattattggc gaaactcatg acattttcat ggtaaccagt
     3481 tgtgtactgc atggctacct caactgtgat atcatccatc tcaccgtctg tatagattgg
     3541 tgtatcaaag attacatcct tgttctcgtt gatatattca acgtaactag caatcccacc
     3601 ttcataatga taatgcttgg tttgttccaa accttcacgc ttatctgtaa ttgaaatttg
     3661 aagaccgcga tttagaaagg ccaactcttg aatccgttta tttaatttat caaaatcaaa
     3721 gattgttgtt tcagtgaaga tttttgggtc cggtgtgaag tgaacagttg ttcctgtttt
     3781 atccgtatct ccaactattt caagatctgc gacaacatga ccacgacggt attcttggta
     3841 atgaatctta ccatttttgt gaacatgaac gtctaattga gtggaaaggg cattaactac
     3901 tgacgacccc accccgtgaa gaccacctga aaccttgtat ccaccaccgc cgaactttcc
     3961 tccagcgtga aggactgtaa agacggtctc aacagcagga cggcctgttt tttcctgaat
     4021 atcgactggg ataccacgcc catcatccac aacagtaatc gaatcatctg gctcaataaa
     4081 aacttgaata tggctggcaa atcctgccaa ggcctcgtca attgagttat caacaatttc
     4141 ccagactaga tggtgaagac cttcttttga ggttgatcca atgtacatcc ctggacgcat
     4201 acgaacagcc tctaagccct ctaaaacttg aatttgactg gcatcataat cctgtgcctg
     4261 cagatttttg atttcttctg tcatcttatt cctttttctt atatgtctaa tacttgtctt
     4321 aaattcacga tactggtaaa caagtgggta tcaagtcctg cagcttgacc tgcttcgata
     4381 tcaatcggcc gatcaccaat gacaagacca gagctaatct gatacttttc tcttaaataa
     4441 agcatggatt cgggatttgg ctttctctta aagcctgagc tagaagtcac cacttctgta
     4501 aaataagctg ctatagaggt tttttctaaa atttccaaaa cctgatcatt tcgatgagag
     4561 accaaaaaat gacggccacc ttgatttgaa atgacttcca ataggtcaga aactccttca
     4621 aataaaatcg ggtgttcaag ctctctggct tcattttcct tgtacttttc taaaaaattc
     4681 tctaaattgg gagcgaatgt ctcaatcgca aaaggagtag aaacctttaa agcttgatag
     4741 acactgtcat ggtcttgtgt gataccatac agtgccaatg tttcaacaaa tgcagctgtt
     4801 gaagtttcat aattatccag taaagttcca cctaaatccc agatgtaatc gtgatatttc
     4861 atacccttca ttatagcatt tttttatgaa aaaagcgatg atttccctga gttttccaca
     4921 taaaaaacga gagaataact cccgttttac tgatttttac caaagacatc tcgatagagc
     4981 attcctgttc gtaaactctc tgcgtcccct cctagttgct ccaccaactc gtaggcaaag
     5041 gcaagggctg ttgaaggacc ccgactggtt gtcaactgac catctaccac tactgtttcc
     5101 ttgacgtagt gaccatcaag gatttgctct tgaacgccgt cataacaagt gtatcgctta
     5161 tttttcaata tctctgcttg attgagggca attggtgccg cacaaatggc tgctagtttc
     5221 ttcccttctt gctcgaagct ttgcaattct tgaatcaagg tctgattatc acgtaaatgt
     5281 gcagaaccag gcatacctcc aggaagaaca atcatatcat agtctgataa atctccatca
     5341 aagacatgat ctgctcttac ttggattgca tgcgaacccg ttacttgctc ttcaaaacca
     5401 accatatcac atgtgatatt ggctcgacgc aagacatcta caactgtcaa ggcttcaatt
     5461 tcttcaaagc cctgagctaa cataactgct acttttacca tgattttctc cttatttaat
     5521 ttgttttaat acaacctttt tccgtttgaa tgggactttt ccgctctttt cttcagctag
     5581 attagtctgg taactcatcg ataaaagcaa accaacacca atcagattac tgataatagc
     5641 tgatccccct tgcgaaatga aaggcaaggg aatccccgtc aaaggaagta gtccagtcac
     5701 agcaccgata ttctcaaaga tgtggaagag caacatcata atcaaacctg tggaaatata
     5761 agtgtagaac tggttatttg atttaagagt aatcttcaac atacggtaaa tcaacatgag
     5821 atagagggca ataaccagga cagagccaat aaagccaaaa tcttctgcaa taaccgtaaa
     5881 aatcatatct gactctcgaa ctgggataag cagattcgaa gcattaaatc cctgaccaaa
     5941 taagccacca ctcccaatgg caatctgccc ttgagcctgc tggtaagtcg ttgtttgggc
     6001 aaactcaaag ggattgagcc aagccaaaat ccgattaatt tggtaggtcg gcattccaat
     6061 ctggtgaaga aaagctcgtc cgtccttgct aataaagata gctaagaaac cagcaactcc
     6121 tgttacagca gtcacaaata ctgggataat aattttccaa gaaacccctg ataataaaac
     6181 gattcctgag aaaatggcta caaaaaccaa agccgtcccc aagtcacttt gaagtgctaa
     6241 aagaactagg actggaatgg taaagagaat catccagaaa attaacaaaa agtccagcgg
     6301 aaccgtgcgt ctccattcct tatgtttctt tgtaaattgg acaatgacac gagccaacat
     6361 gaggatatag gatatcttca taaattctga cggttggaat agggtaattc catttattga
     6421 tacccagttt ttggcacccg ttgatgcaac taagcttgga ttataaaata caatcggcaa
     6481 gatcataagt cccaagccta aaatatatag aaagggggtc accttccaaa gaaattctgt
     6541 attaaagagc atgaccacaa aaccaatcac aagccccaag gcaatccagg cgacctgctg
     6601 ccctaaaatg ggcagaatat tattgggata atcatgacta acggctatat agatagccac
     6661 cacaccgatg accagtagaa aaaatactgg caagagcaaa ctgtaatcga ctcttgagtc
     6721 gagagaacgt ttcatatata ctaaccttat actttcatac aatactattt atcaaagttc
     6781 attaaaaaat ctatcaatag cctcgtcaac ttcggatcga gagatggttt taacagtcgc
     6841 ttcttctgct agagatgcta ctatttgttt gccgtatcgt tttccgacga ttctcctatc
     6901 caaaataaga gttaaggaac gttggtattc acgtctcata cttcttccca aagcctgttt
     6961 taaacgaata atggccattg gcaattgata atcataaaag gcatttttcc cttcttgatt
     7021 cagttcttga ttaatctttt tcgtcaaggg ttcttgagga ttttggaaag gaagcctcgg
     7081 tacaacttga atcacaaaag gatggcttga aaaatcaact ccctcccaga aacttgctgc
     7141 accaagcaag atttgttgtt cacctttttc aaagcgtttc tttagctgat gaacatcccc
     7201 atttttatac tgggccaagt ggctaactgt aagtaaatcc gatactgcta gaagcatgtc
     7261 tttagcggta aagagaacca aaatcggttg ctggaaagct tgaatttcca ctagtaaagc
     7321 agctacctct ctggcataga cttctaagga ggtttctgtt accagaggga aatctttgac
     7381 catgaccact tcttgttcct gttttccccg agattcaatc ttgacaaatt tagcttcagg
     7441 atagcctaaa aggtctgcca aagaaaccct ctgactaatc tcaagagtag ccgatactcc
     7501 caggacttgg caactctcag gaagtaaaga ggacagaaga gtacggcctg attttgtaga
     7561 agaaatctga attttctttt gactcgtttc agttacttca agccagtaat caccttcagc
     7621 tgtaaaatag cgaaccagct catcaaagcc ttctacttct aattctgaaa aatactgatg
     7681 gagattatcc agagaatcta agatattttt cctagatttg ccagactgaa attgttctat
     7741 caagtagaga cactcaaagc gaatactttc tagtatccgt tgttgaaccc tgttttcttc
     7801 tcctactaaa gccttatcaa ttaaatcgat aatagattgt atatcgtagg tctcttgaag
     7861 cagattttct agagctaaca aaatcttttg gacttcatca ataatcagta aacggtcact
     7921 gacaaattca ggattatctt caagtctggt cacgagatag gcatgattag tcactaaaag
     7981 cttgcaagtc tctgcccttt cttgactacg tttccaaaaa tcttccgtca caaataagct
     8041 atgggatgat aaattcccat catgacgaag gtctgctaga aaatgttggt aacggtagag
     8101 ttgcccgatt tcatccaaat ctcctgtctc tgtctcagta agccagacca agacttgcat
     8161 tttaaagcgt ctaaataagc gattttcatc attttcctgc aaggaatgat aaaaggcatc
     8221 caacttcaga taattttgtg gtccctttaa gctatgaata tctgtatgga acacttcctt
     8281 gagacgttta ccttcttctt ccatgatttg attttgaaga atctttgtcg gaacactaag
     8341 aacaatttgt cgctctttgg attgagataa agcgggtaag agatagccat aggttttccc
     8401 aatccctgtc ggcgcttgaa tcagagagac aggttcatct ttcaatagca agccaacctc
     8461 tttagcaaaa ctttcttgtt cctccctcac ttcaaggttc aacagagaaa tatttttaga
     8521 aaagtcttga gatagttttc gtagctccag agaagctgcc gttttcttaa aatacagacc
     8581 ttgaacttgg accaagtctg gagaactcag gatagattgg ttgcgataag tttcctcaat
     8641 aaccaggtag gactcatata ggagagcgtc agccatttcc agcaagcgtt ccaagagacc
     8701 tttaggaagc tgggtcatct tttcccgtaa aaaaagaagt aattctgctg tagcttgggc
     8761 atctgaaagg gctgtgtgtg cgtgtttaag aggaattcct aattctcgac acaaaatcgg
     8821 caagctatat ttttccagtt cagggaaaaa gacctgggcc aattcgaccg tatcaacacg
     8881 agggtttctt agctcatagc cttcaaaaaa taaattttcc gccaagagat tagcatcaaa
     8941 ctgaacatta tgggctacaa aaatcccatc ctccaccaag tcaaagattt ttctggcaac
     9001 ttgcgaaaaa tcaggtgctt gcgccagacg ttggtctgtc aatcctgtca gttctttgat
     9061 atgagcatcc aagggttcat gtggattgac atccgtcgta tagtgatcga cgatttctcc
     9121 atcctcaatc acgacaattc ccacttggat aattttagcc ttactacctg tgctagttgc
     9181 ctctaaatcc accacaacat agcgattacc aatcgttttc attataaaaa attataccaa
     9241 aaaaagggcc atttggcacc tgcaaacata ggataatttt caaactcaag aacactactt
     9301 ttcttagaaa tcccatcgaa tagagcattc tagcctgctg atttttttaa aatagtgaag
     9361 aaatacgaaa aattgagaga agaaatgttt tcatcttcct tctctcaacg aatcatgtat
     9421 tttatttaac catgtcagga tcgtagtcat aaaatcctgt atcaaggaaa cggtttttag
     9481 ggtgaagttt acgaacttct tcatccagca agaaggcttg gtcatggcta aagttgccct
     9541 cttgaatcaa gctacgcgct tggataaaga gttttgcaat ctcaacaaag ttctgaccag
     9601 gagtgtagag cccttctagt ttccagcgag taaagccatg ctccaccaat tctgttaatt
     9661 tgatcatcaa atcaaggtca ttgttggcaa agatatgggt cccatgatta tcttcaaaaa
     9721 tggaatagtg gctctctgga tcacttggct cagccaagaa gaggtcacgt ttatgcgtct
     9781 tttcatcatc gatatgtgta aagttatagt agttttgcaa gagtggacgt ttagaatgat
     9841 ggatgacgct agcaccgtaa accaaaactt cagcaggaat ttccaaaatc tctggcattt
     9901 tgaaaagttc agctgatgga atttcacgcg ccaaaacagc ctcagatgcg ccagcctttt
     9961 gtccccagaa gttaatctga cgactgctag ttaccatggt tgaagcatcg tagatggtct
    10021 taaatgaata accatcgcgg ttaactacgt aaaagacgcc tgcatcccca atcgtaatat
    10081 agtctgtctt gatttcttcc aagaagtcta agaaaggctt gatacggtcc atcatatctt
    10141 ggtgcatgag agcattgacc gcaacgagca attccttacc agcatcatga accaacttag
    10201 cgatttcacg taattggtca taactaaagg tcgttggcag acgaaggcca aaatctttct
    10261 caccgacata gatacggtct acgccagctt cgagtagttg ttcaacttgt tcaatacttt
    10321 cagcagttgc tgtaatgaca atcttttcca taagaaaaat tataccacat ttctccaaaa
    10381 tcatccatgc tttgaaaatg aaaagggact ttattctttt tgtaaccttt ctgtaataat
    10441 tttctgccga aaaaatgata aaataggtat gtactgttaa ggagagaatc atgcccgtaa
    10501 gaaaattaca atcctatgag gtagactatc aagaagaatt aaaccagcag cttcctcatt
    10561 accaagctta tacacctgaa gcgcaatctg atgccaatct caaggaaatc ctatttttta
    10621 ttaatatcgc tgttttttgt atctgtattg ctatctttag ttttatcttt ttagcattaa
    10681 aattatcaac tgctcttgcc tttgccgcag caatcggatt cagcttactt gttttaaaag
    10741 ttcaacggtc tattatcaaa cgaaaacgta gaagataaat ccaaaatatc gccccagttg
    10801 gagcgatatt tttatttttt ctttttagat ggtgtctgaa tggcaatctt cacttcaaag
    10861 attgttccct tgggtttatt atctttgaca gtaacagttc cttttagagc atctacaatt
    10921 tgcttggcta gggataatcc taaaccaaaa ccaccttttt gccgggttct agctttgtct
    10981 actcgataaa aacggtcaaa aattttcttt ttatcttctg tcgaaatacc gattccatta
    11041 tcagaaacaa gtaaataaag attgcgatcg gtcgccgaga taagaaaatc aatttcacca
    11101 tcctcctcag tatacttgac ggcattatcg aaaagaatgg tcatcagttg tttcagaaga
    11161 agctgatctg tgacaattgt tcgatggata cgattttcaa aacggaagac acgattattt
    11221 tccgaagcaa tcatctcgta gtttgtgaaa gttgtattaa aaaagctagt tggaacttct
    11281 gcaagctccg gcttaatccc atcatctctc cgagctaagt tcagcaagct tgtcgttaaa
    11341 aaacgcatat ttcggacttc ttccaaactc gatgcaatgc tttcgctcac atccataatg
    11401 gtagcttctg gcttacgaaa aagggtctct aagcgatttt gcaaaactgc gagtggagtt
    11461 cgtaactcat gactggcatt ttccacaaaa gactgttgct tctgcatact ctcaagcagg
    11521 ggcctaacac tgaccctagc tagatagaga ctggcaagta aagacaaaat ccagaaacta
    11581 gccatcacga ccacaatcaa ttgctcatgc ttttgactag cctgctccaa ctgactggta
    11641 ttaatcaaga cagcagcata cttgatattg gttgaaaccg aactaatatt ggtctccatc
    11701 aaaatcacac gatagatttc ttcctgccca tagctattaa aaacctgaat ctggtagata
    11761 tgtcctagtt ctttcttttc taacttaatc ttatccaagc ccaaaaatcg atttccagaa
    11821 agaagttgag taaagtcttt atcaaagaga atgacttccg tattggaact gacattaggt
    11881 tttatttcta ctttactagc gtccgcccta gcattttcta aatctttaat ctcttctgtt
    11941 gccctattta tagccagctg aataactgct tgaggatttt cactcagtcc atgaagctta
    12001 tcgtccaccg aagtataaag actcgaatgc atgacttgta aaataatcag agtcattgta
    12061 gaaaaaatca gggtgaagac accgaagttg cggataaaat aactaaagtc atccgcatac
    12121 catgtttttt taagtttact gaacatcttt taaaagatac ccaacactac gcaaggtttg
    12181 caaattctct gcaaaagtgg ttccctttaa tttcttacgg acttttgaaa catagacttc
    12241 gacaaccgaa atcgttgtat cactatcaaa tccccataga cggtcaaaaa tctgcgtctt
    12301 aggcaaaatc acattttgat tttgaaggaa ataaactagt aaatcgaact ctttccccag
    12361 caattcgaca ggagtatctt caactttaac ggtattggtt gataaattaa ccacgatatt
    12421 cccataagtc aaggtgtttt cattaaactt ccctgaacgt ttgagaaggg cctgaatccg
    12481 cattttaagt tcttctaggt agaaaggttt ggtcagataa tcatccgctc ccagttcaaa
    12541 tccatgtccc ttgtcatcca aactttcctt ggcagtcata atcagaactg gtgtcgtaat
    12601 tcccttttca cgcaattctt ttaagacttg gaaaccattt ttttctggca acatcaaatc
    12661 cagcaaaatc aagtcataga caccactctc agcttcgtag agaccttctt ctccatcaaa
    12721 tacctgcata acatccgcaa aatcgtctaa aaagtcaaat actgaatttg acagacctag
    12781 gtcatcctca accaataaga tttttatcat gagaaactcc tccttattaa aactattata
    12841 ccaaatttgc cttaaaaaaa actcaactct ctgcatttta catgagatag ctgagttttc
    12901 tttttatttt aggcttattt atgcatttcc gtattgaaga acaactgctt cgactgcagc
    12961 tttttcacgg ctaatcaagt caacacgcgc tgcaatttcc ttgattccca taccgatgtt
    13021 acggctaaga gcaaggtcag aaagttgcgg ttcaaagaac tccttgtatt ccgccaagcg
    13081 ttgctgagtc ttaaatacat gagcaggaag gataacaaag ctatcaaagc tcatatctcc
    13141 tccaagggct gccttaatcc aagcccagtt ttcacgcgcc caagaccaag ctgttttctg
    13201 agttgcttga tgagctagga attggtaata ccaagcagac aagtcctgtg gtttgaccac
    13261 aaatttgtcc ttccaagaag taatcaagtt ttggatatta tccgcatctg tactgtatgc
    13321 aagagctgct gtcaactggc gtttaaagac agcatctgtt gcgtgagtat aagtatcaag
    13381 ataaagtgct aacaagtctt tagtctcatg atgtttcatc tcattaatca gaacttgtga
    13441 acgaatagct gctgggagtt ctgcaagatt ctccttgtgt gttgcgaaga tttggctagc
    13501 gacttgacga gcttctgcat catttgagcg aatcatcatc gaaacagcca gctgacgaac
    13561 caattcatcc tcatctgatt ctccgtcttt agcttcaaaa ccaagacggt catagttatg
    13621 acgagccaat ttagcaacca gtcctttgaa ggctgtttca gcatccgttc cttcatcaat
    13681 aaagcgctca agggctgaaa tcacttgaga aacagctgaa accaccagat aagactcttc
    13741 cttagcaagt ttatcaagaa ctggaagcaa gtctgcataa gaaatgtgcc ctgcctcagc
    13801 caacaaacga cgttcttgaa caatttgcag tttgcttgtg ttatcaagtg tctctagctc
    13861 agcaagaaca gcttctaaca agtctccttg atagtcggta atatagtggg cagtattttc
    13921 agtgttgaga cgaagagctc cttcattttc agcaagaaga gctgcgtagc cagggatttc
    13981 gatactttca gtttcgagtg tatcaggcaa gcctttccag ttgctattga ggggcaccac
    14041 ccagagacgg ttcttgtctt cgttctcacc gatgaagaat tgtttttgtg aaatcttcaa
    14101 gacatcattt tcaactttga cagtaagaac tgggtaacca ggctgttcca accaagaatc
    14161 catgaaggct gcgacatcac gtcctgacgc ttgaccaagg gcatcccaaa ggtcactacc
    14221 aatggtgttg ctgtattggt gtttttcaaa gtaggcatgc aaacctttag caaaatcagc
    14281 atctcctagc caacggcgaa gcatgtgcat gagacggctt cctttggcat agacgatagc
    14341 gccgtcaaag agtgtattga tttcatctgg atgtttaact tcgacgtgga cagactgaac
    14401 gccatcagta gcgtcacgtt caagagcaag aggtactcca cctgtttgga aatcttcaaa
    14461 gatattccag cttggttcga tggtatccac acagacgtat tccatcatat tagcgaaact
    14521 ttcattgagc caaaggtcat cccaccattt catagtcacg aggttcccaa accattggtg
    14581 agccaattca tgggccacaa caagggcaac ttgttgacgg ctagcaaatg tagagttctc
    14641 atcgacaacc aagtaaactt cacggtaggt cacaagaccc cagttttcca tagcaccagc
    14701 tgagaagtca ggaagggcga tgtggagaga ttgaggaatt ggatacttaa ctccatagta
    14761 atcttcgtaa aactcgatag agcgaacagc gatatccagt gagaaatcaa gatttgaaag
    14821 tggatgtgct ttggttgagt agacacctac cagggtacca tttttagttt tagcggtcac
    14881 cccttgcaaa tcaccagcaa aaaaggccaa caagtaagaa gacatgcgag gtgttgtctc
    14941 aaacttccag atacctgttt ccttacggtt ttcaacatcg atttctggca tgtttgacaa
    15001 ggccaattca ccttctgctt ggtcaaagcg aagagagagg tcaaaagttg ctttggcttc
    15061 aggctcatcc acacatggga aagcttcgcg cgcaaaatgg ctctcgaact gagtagacaa
    15121 gacctccttc ttgactccat caactgtata ataagaaggg taaatccctg tcatgttgtc
    15181 tgtaatttta ccagaaaagg caagaaccaa ttcaacttga ccagcctcag ccaattcgat
    15241 atgaagggct tcattgtcat ggtcaactgt aaatggacga gcttgacctg caacttctac
    15301 agaggtgatt tccaagtctt tttggtggag ggagatgcgg tcactctgtg cttgaccagt
    15361 gatggtcact ttcccagaaa aagtcttggt ctcacgactc aaatctaaaa ataaatcata
    15421 atgttcagga acaaattgct taataaaatg ttcaactgct tgcatagttt tctcctattc
    15481 taagtttaag agctgctgct cttcttcaaa caaacttatt atatcatatt ttgcttgaaa
    15541 aaaaaggatt ggacagcgat ttccaaaact ttcttccttc taatagtcta cagtgggtag
    15601 accttgcgaa attcttctaa aacaaccttg ctttcagatg taaaagtcag ccctacttca
    15661 cccaaacagt ctgtgaaaaa gtcctcatga acctggcgcc aataggcaag tgatttgtct
    15721 ccctcacctt ccttaaaggc atgttgcgca gaaacttgat tgaagagttc aacagaaacc
    15781 tttgtaattt cgacaatgca gacagactga ttttgactat ctaaaatgat atcgaaggtc
    15841 cctacttggg gaagtggttc gtcttctagt acatagaggt cataggctga tgctgttgct
    15901 gtcttttctc ctttaaacac caaatccgct aaaaggtctg gttcaactcc aaaagcccaa
    15961 gcatcgattt catctccgat caaaggattg atttgcttgt atttattcca catttcttgc
    16021 ggtatcatgg gtactccttt gtaatttttt actttcttct tttatgtgtt taagatgatc
    16081 tggatggtca atctctaaat caaaaatctc tggaatagaa ctgtagtgga taatgcactt
    16141 gatacccaac tgattcattt tttgtatgaa agaagtattc agatagcctg ctacagcaaa
    16201 attaatcttg ttctttcttg ctttatcctg catatctctt agcatatcta acattattgg
    16261 actttccaga tcatgccatt gactgtttct catagtcgca aaaacaaagg aagtcaaatc
    16321 attcattcca actacaatct ttgaaatgcc cgtttccagt atactagata agtcaaaata
    16381 cgctgacggt aattcaatca tcgttccgac tttcccagta aagccatact gacgcaatgc
    16441 tgtaatagct tgttttaatt ggtcggcatc attggcaaaa ggaaagataa cagatagatt
    16501 ggggttggtt tgataaactt ctgtaacgac atgtgcttca gcctgaaatt catccaaaca
    16561 cgccagtaaa cgcctggttc ctctatagcc aaacaaggga tgcccttcgt caaaaaactc
    16621 tttagtcccc actaaacaat tggcttctgt attcgttaat tcagtaaaac gataccaaac
    16681 ttcttcatct gagtacaggg agcagatagt ctctagataa tcttttacaa attgctgaca
    16741 acttgctaat atgatgtttt gattaagctc tctcaacaaa tattccccac gaatcatgcc
    16801 gacgtggtga aatagttgag gataaatttt ttcaagaatt ttttcgccac taagggcaag
    16861 ttgatttctc atcattcacc ttccaattca tgtaagaagt cttgtccagt tctggaaatc
    16921 ctaataattc agacttaacc ttcaagacta atggcgatgc attttcttct gtaatctctt
    16981 gaatatccat ccaaatatat ccaagtgaat cattcgcacc atcagacaca gcttccgaag
    17041 tcgtaacttg aggtgcactc tcattcattt caacatcata caaggccatg acatggtgaa
    17101 ccataaaatt tgttaactct tctctgacga aaacatcgta gattcgagga ttagagtagc
    17161 ttctaacagt aaatcccgtc tcttccataa cttctctagt cagcgtttcc gtcagtcctt
    17221 caccaagttg ctgactgcct ccaggtagat cataccgatg ttgataaggg cctctcgttt
    17281 tttcaatgca gagtaacttc ccattttcta agcaaacagc gtagactcca aagtgttttt
    17341 tgatttccat ccaactcctc ctacttcaaa gaccagccac catctattgt caagatttgt
    17401 ccttgcatgg cgctcgcttt tccacttgct aaaaaaagac taagctctgc tatttcctct
    17461 ggctcaatcc agcgcttgat tggggtttca ctagccaccc agtcagccaa accacctggt
    17521 tcaaaatccg cagcggtcat agctgtcttg actgctcctg gagcgatacc aaagacctga
    17581 atcccagctt cagcatagtc tagagccaac tgcttggtga agccagccaa ggcatgcttg
    17641 gatgaagtat aggcgtgacc acctccacct gctaggctag aagcaatgga acacatattg
    17701 atgatgattc cctttttatt ttccagcatt tgtgtcaaat aataccgagt caactctact
    17761 ggaataatgt agttgatttc aaaaatctct tgaatgtcct gcgccgtttg ttccaacagt
    17821 ggtttgtaat catccaaaac tccagcagta ttacacaaaa catccacctg agggcaccag
    17881 tcaaaaatag gttccaagtc caaggtcaaa tctctctgta aaaagtgaaa atcaccctct
    17941 aagagtggct tttcaccttg gtcaactcca taaacttgat agcccttctc taaaaagagg
    18001 cgagcttgag ccaatccgat ccctgaactc actcctgtaa tgagtacacg tttagtcatg
    18061 cacttctacc caatccgttg ccaaaacatc acaaactgtc gggctccaca tggaaaaacc
    18121 ttctccttcg ccagaaacgt tgattaggaa ataaggtgtc atttcaagtg caagcccatt
    18181 ttgctcgatg gtatcaaaga gttggacata gttttccgca cctccccaac cagttcgtac
    18241 atattttctc ttagccttta acccaggcag gatctcttca aatgtcatgt ttttctcctt
    18301 taattctaca ttcttcattt aattatagca aaaaaccgct ttatacggct ttttgaatgt
    18361 gagttattca aacctgctac tacttacggc aaattattcc ctgcagcaag ataaatttca
    18421 taccattctt ttcttgttaa gctaaagttt gccgctcggc taacttctct caagtgctta
    18481 ggatttgttg tacctacgac tgcctgcatt tttgctggat aacgcaatat ccaagaaatg
    18541 gcaatagttg aagaggttac tccatattta atagctaaac gatcaagtac ttgatttaaa
    18601 gcttgaaatt tctcatttcc aacaaaattt cctttaaaat acccgaattg taagacagac
    18661 catgcttgaa tgaccacatc gtgtaattgg caatattcaa aaatgctgcc atctcgcata
    18721 gctgcttgac tatcttccat attaacatga aaagctgatt caaatcctgg agtaaaagcc
    18781 gcactcaatt gtagctgatt aacagctaac ggctgcttga catctttttt aagcaactcc
    18841 atcatcatag gattttgatt agaaactcca aaatctcgaa ctttaccttg tttataaagg
    18901 agatcaaagg cttctgctac ttggtcagat tccatcaaag catctggtcg atgaaggagc
    18961 aagctatcta gatgatcaat cttcaatctt tgcaaaatac cgtctactga ttttataata
    19021 tagtccttag aaaaatcaaa ataggtaaat tcttcaatgc gaatgccaca tttggactga
    19081 atccacatct tttctcttaa atctggacga ttttttagga caagacctaa cagttcttca
    19141 caacgaccac gaccataaat atcagccaag tcgaaggcat tgattccaac agaaagtgct
    19201 gtttctacaa gctcttcaac ttcttttaca gatttatctt ttattctcat cattccgaga
    19261 acaatttctg ataattcttt gtcatcttga ccaagagtta tgtatctcat caaatttttc
    19321 tcctttaatt tctaacattc ttcccttcat tataacaaaa aaccgctttg caacgacttt
    19381 ttgactatac ttcactccat tttatcttct taaacccacg gaacaagaca aagattccaa
    19441 taaagaggac agctaaagga ataacttttg taaggaaaac atttgaaatt cccatccact
    19501 cataataacg gagcagagaa cccaccacaa gatgggcaat aatcatactg acaaatggac
    19561 gaaagaccgc ttctttccaa ttccaaatac cgataactag cgaaatcgta aagatagaca
    19621 aactatccca gggagccgga atataaaagg ctccttcttg tatgaagctt gccattccta
    19681 catatcctaa aacaactaga agaactatag tcccaacaac aatgtaagtg ccaattttca
    19741 ttttaggaga atcttggact aaacttcttc gtaaaattgt ggccacaagt ccaaatccaa
    19801 tcagaaaaat aagaagttgc cctaaaaatg tgagcaaatt gactgttaag agaggacctt
    19861 tagaaaaatc acttagtagt tgataataat gtaataccgc caggacaaga attggcgtca
    19921 aaagggactc tttgatagaa ctgcgaggtg ctcccttgag aatctctttc attatttttt
    19981 taggattctt acctagataa tcctctgcac tcatgccatc tcgttctgct tctgagaaat
    20041 ctagcatcat caaatagatc tgctctctga gatagtcttc atcatagaga aatccagcaa
    20101 gattaaaact ttcccacaac tcctcaaaat acttttgatt ctcctcagaa aactcatgta
    20161 gcaaagcgct tgtttcttcg taatacttca ttttcttcat ggtttaaccc ccattcttaa
    20221 tcccttctac tttttgactc aaatcgtccc attgttgcca aaagactgag acacgctctt
    20281 ctccttcttt cattaatgaa aaatacttcc gatctggacc atctggcgac gggcgcatgt
    20341 cgcctcttat ccattgattt ttttctaact tttgcaacaa aggataaata gttcctggaa
    20401 cgatagtatc aaatccagcc tctcgcaaag tctgaaccaa ctcataacca taccgctctt
    20461 tttgaccaat catatccaag acacaacctt caagaacacc ttttaatagc tgagtttctt
    20521 tcatcacttc tcccttctaa tctattttgt aatacctact agtaacttca cctatagtat
    20581 attacttcta cactagtttg taaagcataa tagttaatac tcttcgaaaa tctcttcaaa
    20641 ccacgtcagc gtcgccctac cgtatgtatg gttactgact tcgtcagttt catctacaac
    20701 ctcaaaacag tgttttgagc tgacttcgtc agtttcatct acaacctcaa aaacatgttt
    20761 tgagctgact tcgtcagttt catctacaac ctcaaaaaca tgttttgagc tgacttcgtc
    20821 agttctatct acaacctcaa agcagtgttt tgagcaacct gcggctagct tcctagtttg
    20881 ctctttgatt ttcattgagt ataaataaaa aaacagaact agcctgaact agtcctgtct
    20941 acttttaccc aatcacactt ccatttggta cagctggatc aactgtgaga agggttaatt
    21001 tgccatcatg ttcagctgag agaatcatac cctggctgac atattttttc atcattttac
    21061 gtggtttgag gttagcaacg atttgaactt tcttgccgac caattcttgt tcatttggat
    21121 agtattttgc aattcctgaa agaatctgac gatcttctcc atcaccagca tccaagcgga
    21181 attgaagcaa cttatctgaa ccttctactt tagacacttc tttgacttct gcgacacgga
    21241 tttcaacctt gtcaaagtct tcaaacttga tttcatcctt gtttagtttg agctcaactt
    21301 cgtccggatt ccattctttt tcgactgctg gtttattgcc ttccatttgt tccttgatat
    21361 aggcgatttc ttcttccata tttagacgtg gaaagatagg tgttcctttg gcaactacag
    21421 tcacatctgc tgggaagtca gccaaactca agttttcaag actagaaact tcttccaaac
    21481 caagttgagt caaaactgca cgactagttt ccatcataaa tggttcaatc aagtgagcaa
    21541 ctacacgaat gctggctgcc aagtggctca tgacacttgc caattggtca cgaagagctt
    21601 catccttggc caagacccat ggtgcggtct catcgatgta tttattggta cgagagatca
    21661 gagtccagac tgcttcaagc gcacgtggat agtcaactgc ttccatgtgt gtatggaagt
    21721 ctgcgattga ttgttctgca acctcagcaa gaacatgatc aaattcagtc acaccttcta
    21781 cataggcagg gatttgtcca tcaaagtact tattaatcat ggaaaccgta cggttaagga
    21841 ggttcccaag gtcattagcc aattcatagt tgatacggcc gacatagtct tcaggagtaa
    21901 aggttccgtc tgaaccaact ggaaggttac gcatgaggta gtaacgaagt ggatctagtc
    21961 cataacgctc taccaacatt tcagggtaaa cgacattccc ttttgactta gacatttttc
    22021 cgtctttcat gacaaaccaa ccatgggcaa tcaaacgatc aggtaattta acatccaaca
    22081 tcataagaag gattggccag tagatagagt ggaagcgaag gatatctttt cctaccatat
    22141 ggaagactgt tccattccag aacttgtcaa agttaccatg ttcgtcttga gcgtagccaa
    22201 gagctgtcgc atagttaaga agggcatcaa tccaaacgta gacaacgtgt tttggatttg
    22261 atgggacagg cactccccat gtaaaggttg tacgagatac cgccaaatct tccaaacctg
    22321 gctcgatgaa gttgcgtagc atttcattaa ggcgaccatc tggcgtgata aattcaggat
    22381 gagctttgaa aaattcgacc aaacggtctt ggtatttgct aaggcgaaga aagtatgatt
    22441 cttcagaaac ccattcaacc tcatgacctg atggagcaat accaccagtc acatttccag
    22501 cttcatcacg gaaaacttct gccagctggc tttctgtaaa gaattcttcg tctgatactg
    22561 aataccaacc agagtattca cccaagtaaa tatcatcttg agcaagtaag cgttcaaaga
    22621 cctgtgcgac aactttttca tggtagtcat cagttgtacg gataaattta tcgtatgaga
    22681 tatctagtaa ttgccagagt tctttaactc caaccgccat tccatcaaca taggcttgag
    22741 gtgtaatacc agcttcttcc gctttctgct ggattttctg accatgttca tcaagacctg
    22801 tcagataaaa tacatcgtag cccatcaggc gtttgtaacg tgctaggaca tcacatgcga
    22861 tagttgtgta ggcagaaccg atatgaagtt tcccagatgg atagtaaatc ggcgttgtaa
    22921 tataaaaatt tttttcagac ataatttttc ctttccaggc aaatgaaacc tgtttttcta
    22981 acacttcatt atatcacatt tttaatgaat ttcgataggg aaatccatac aaaaacaaga
    23041 tagacgagtg tccatcttgt tgatctcatt cataacgaag ggcttcaatt ggatcaagtt
    23101 tcgatgcctt gttggctggc aagactccaa aaatcatacc aacactagcc gaaactgcaa
    23161 gactaaatag ggcaactggg attgatactc caacttctat accttctatt aaaccttgca
    23221 gtaacaaacc tgctaaggca gttaaaccac ttgcaattgt caagccaatt aagccaccta
    23281 acaaggtcaa aatcatggat tcaatcaaaa actgaattaa aatattggca cgtgttgcac
    23341 ccaaagcctt acgaagacca atctcacgag tgcgctctgt caccgaaacc agcatgatgt
    23401 tcatgacacc agttcctcca acaaagagag aaatccctgc gatggaacta ataatcgtcg
    23461 tcataaaact aaacgattgt tgaatttctg caaatacaag ggactcatct gccacctggt
    23521 attctccctg ttgtaagcct gcaagctctg tcatttttcg tgccagttct ggacccagag
    23581 ttggggttaa actggtatca ttcactcgaa agacaatatt agctatttca tctacattaa
    23641 aattcgcagc aagggagata ttggtagtaa taggcaagcc accaaaccca tatatttttg
    23701 atcttttagc ctccggacta gtataaaccc caatgacccg gtaactaaat ccattgactt
    23761 ctacaacctt gttaatagcc tcttgaggag attcaaataa actaatggac aattcctcat
    23821 ctagcaaaat gacacttgca aactctttga aatcttgctc tctcagacta cgacctgcaa
    23881 taatttcatt cttaacagcg tccatgtaag ttctgtttcc acctgtcaaa ttagcattct
    23941 caaccttttt atcttgatag gtcaagatgg cattcgttga attggttaca tagtaactat
    24001 ccactccctt cagtttagct gcctcttgga cccaggattc ttgcggtttt ggcggttcaa
    24061 caggaacttc ctcttccttt ccagaaaccg taaaagctga ttgtttctga gtaaaagacc
    24121 catctttact ttttttagga gagaaaaaga cgctaatatt tttctgagat ttagtcatat
    24181 ctttattgac ttgacgagat agggaatcac ccaaagccat aatcacaaca actgatgaaa
    24241 caccgataat aatcccaatc atagtaagca aagaacgcat cttgtgagcc atgatagatg
    24301 aaaaggcaaa tttcagattc tgcatcttag ttttcctcct ttcctaactg agcactgtca
    24361 gacgaaatga ccccatcccg aatgacaatc tgacgtttgg cataggcagc aatctcaggc
    24421 tcatgcgtta ccatgataat ggtttttcct tctttattca aatcaaccaa taattgcata
    24481 atttggttac ctgttttggt atccaaggct cctgtcggtt catccgctag gataatagaa
    24541 ggattgttta ccaaggcacg cgcaatggct acacgttgct tttgaccacc agataattct
    24601 gaaggtaaat ggtgactacg ttctgtcaat tcaaccttgt ctaaatattc ctcagccaac
    24661 ttgcgacgtt ttgaagacga aactcctgcg taaatcaagg gcaattctac attttgcaga
    24721 gcattgagct tcgatagaag aaagaactgc tgaaagacaa aaccgatttg ttggttacgg
    24781 accttagcta gttgtttttc accaagccca gccacttctt gaccttcaag ataatattct
    24841 ccactggttg gtgtatccaa catgccaatc gtattcatca gagtggactt accagaccca
    24901 gatggtccca tgatggctac aaattcaccc tcattcactt ctagattgat atttttgaga
    24961 acctgcagtt cttggtcacc attacggtaa cttctgaaga tattttttag actaattagt
    25021 tgcttcatca gccttcacct cttttccttc ttccaaggaa gatgttggat tactgatgac
    25081 cttagcaccg ttcgttaaac cagaagtgat ttcttgattt tctgcgtcag catttcccaa
    25141 tgaaacctca acttttttag ccttttgttg ttcatccaca atccagacat aatttttact
    25201 atcatccatt actagactgc taacaggaac aagaatagcc ttagttttgc ttttaacctc
    25261 aatgttgaca gaaaaacctt gtttcaaatc accaacctcg cctgtcacat caatagtata
    25321 agggtattta gaacctgtat tattcccggc tgctggacta gctgcttcac cattgttttt
    25381 aggatagtca gaaatatagc ttaatttccc agtccatttt ttatcaggat acactttaga
    25441 agtaaagctt acttcttgac ctacagaaag gttggctaga ttgtactcag acaattctcc
    25501 cttgacttgt aaattttcat tgctgacaat atgaaccata acttgactcg cccctgttgg
    25561 agatttagaa acattgctat tgacttcgac tacagttccc tctagggtac tgagaacagt
    25621 tgttgcatcc aattgacttt gagccttgct taattgcgct gcagcatctg cacgcgcatc
    25681 acgggcatca cccaattgag catcaataga agcaacagaa tttccagcca ctggagttgg
    25741 gctttgcacc gttgcatctt ctcctcctac tggcgctggt aactgtggag cctgagctga
    25801 agcggcttca tttcgtgctt gattgagttc attgatatga cgatctgcct tagctactgc
    25861 tcgactagct gaatcatagg ccgcctgcgc ttctgaacta ctgtacttga ctaaagcctg
    25921 cccttcgctg accttatcgc ccacagaaac aaggatttca tctaaatcac ccttactagc
    25981 atcaaaataa acatattgtt cattttttgc tgttactgtc cctgacaata aaacagagga
    26041 tgccacgctt ccttcattgg caacaacaag atgagtaggc tcatctttta gagcagtctg
    26101 agaaggttgt ctaaagagta aaatcccccc ggcacccaat acaactacac tcgcagcacc
    26161 gattgctgca tacagttgcc actttttagc tttaccattc tttttcttca taatgaaact
    26221 ccttttcttt tttacaatac tttgctatta taccaaattt ccctccagca aacaatgcag
    26281 ttcagatgga aataatggca gttcaggatt aaacaatcgt tcggaatttt gcttttctat
    26341 tgtactagat atataataca ctatcttgac ttatttggca agcttttttg caattttttg
    26401 tgcgtagcag atttttgcaa tcaaatcaaa aaaagaataa aatataacta tcaaaaaaga
    26461 cactctacta tttaaaagat tacaaaggag ttttcaatga gagaatatga tatcattgct
    26521 atcggtggag gtagcggagg aatcgctacc atgaaccgtg ctggtgaaca tggagccaaa
    26581 gcagccgtta ttgaggaaaa gaaattaggt ggaacctgtg tcaacgtcgg ttgtgttcct
    26641 aaaaaaatca tgtggtacgg ggcgcaaatc gctgagactt tccatcaatt tggagaagac
    26701 tacggcttta agactactga tcttaacttt aactttgcaa ccctacgtcg caatcgtgaa
    26761 gcctacattg atcgcgctcg ttcttcttat gatggtagtt ttaaacgcaa cggtgtagac
    26821 ttgattgaag gtcatgctga atttgtagat tctcatactg taagcgtaaa tggtgaactg
    26881 attcgtgcta aacatatcgt gattgctaca ggtgcccatc caagtattcc taatattcct
    26941 ggtgctgagc taggtggctc ttctgatgat gtatttgcct gggaagaact tccagagtca
    27001 gttgccattc taggcgctgg ttatatcgcc gttgaattag ctggcgtact ccacactttt
    27061 ggtgtcaaga cagatctctt tgttcgccgc gatcgtcctt tacgtggttt tgattcctac
    27121 atcgttgaag gtttggtcaa ggaaatggaa agaacaaact taccacttca cactcacaaa
    27181 gtccctgtca agttagaaaa aactactgac ggcattacca ttcatttcga agatggtact
    27241 agtcacacag ctagccaagt tatctgggct acaggccgcc gtccaaacgt taagggcttg
    27301 caacttgaaa aagctggagt gactctgaac gaacgtggct ttatccaagt ggatgaatac
    27361 caaaatactg ttgttgaggg aatctatgct ctaggtgatg taacgggcga gaaagaactg
    27421 actccagttg caatcaaggc cggacgtacc ctatctgaac gtctctttaa cggaaaaact
    27481 actgcaaaaa tggattactc aactattcca actgttgtct tttcacaccc tgctatcgga
    27541 actgttggtt tgacagaaga gcaagctatt aaagaatacg gtcaagacca aatcaaggtt
    27601 tacaaatcaa gctttgcatc tatgtactct gcttgcactc gcaaccgtca agaatcccgt
    27661 ttcaaactca taacagctgg ttcagaagaa aaagttgtcg gacttcatgg aattggctac
    27721 ggcgttgatg aaatgattca gggatttgcc gttgctatca aaatgggagc aaccaaggct
    27781 gactttgacg caactgtagc gattcaccca acttcatctg aagaatttgt aaccatgcgt
    27841 taatcgaaac aaaagaagct gatataaata tgtctgcttc ttttttaatg attttcgaat
    27901 caacaaaaaa ttatccaact tgactagtca cgaaaatcgg ctgttacagt ttttgttacc
    27961 ttgtttttaa aaaatggttg acatcgactc ctatatgagt ataatagtta ctatacatta
    28021 gaaaagaggt taactatttt gaaaaaagct cacgtttatg ctatccctgc tattggggct
    28081 gctctcattg ctgttttggc acaaatcagt cttccaattg gacctgttcc cttcactctg
    28141 caaaactttg caatcggctt gattgctact gtctttagac cgagagaggc tgtactttct
    28201 gctggactct atcttcttct aggtgctatc ggtcttcctg tctttgcagg aggtggagct
    28261 ggttttcagg ctttagttgg ccctactgca ggctatcttt ggttttatct cgtttactct
    28321 ggacttactt cctctctaac caacagcaag agtggtgttg ttaagatttt tcttgcaaac
    28381 ctcttgggtg atgcccttgt ctttgtcggc gggattctca gcttgcattt cctagctgga
    28441 atggcatttg aaaaagctct tgttgtgggg gttcttccct ttatcattcc agaccttggc
    28501 aaacttctgg ctattagttt tattagccgt cccctacttc aacgccttaa aaatcagact
    28561 tactttacta actaaaaaag gataccgagt tatcatgact caatatcctt ttttttattt
    28621 tgaaaactta tactcaatga aaatcaaaga gcaaactagg aagctagccg caggctgctc
    28681 aaaacactgt tttgaggttg tagatgaaac tgacgaagtc agtaaccata catacggcaa
    28741 ggcaaagctg atgcggtttg aagagatttt cgaagagtat tagttgcctt taaaggcatc
    28801 caccatcgtt tgaaattctt catttgagag agtaatccct ttgcccattt tagtatggtc
    28861 tggactccaa gcacgaatat caaactttgc aggggcacca ttaaagctca cacggttaat
    28921 ttccttggtc caaccttttt cgttttcaga aagagtcaac aagtgctctt cgatttcaaa
    28981 tgtaaattct gccattttct tctccttttt tagtttcatt agtttattcg taaaatcttg
    29041 tagattttag gaaaatttta tataatattg atataaaaga agggaggcca atatgagaca
    29101 taaattccag caagttctag ataaaataca tgatttttta aatggacatg accaacctga
    29161 ccagactgaa accaactccc ttacagccac tattgaagag gctatccaga aacaaaccgc
    29221 tgttcacctt atcttgtctg agacaagctt tacaggtgat atcatcaaat atgatcagca
    29281 aggccagcaa attatcgtga aaaatttttc caaaaatgtg agccggatta tccgtataag
    29341 cgatattcaa cgcctgcgat ttgtcccctc aactgtccaa acagcccaaa aaaatagatt
    29401 taagaaagag tgagatgtag ttgcttcatc ccactctttt tcttagcgaa tttgttcaaa
    29461 atgtaaatga actgcgatat gatctccata accacttctt tccaagtcac gttgtaaacg
    29521 ataggaaata tagtgttctg caatggtaat gtaacctgcg cccaataaac gatgttcaac
    29581 catagattga atcatactga tagtcgcacg ttccaccttg gcttcttgta aatccaaaac
    29641 taccttctta gtgacttgag caagattttg acgcaaatca tctgtcaaaa cataaacagt
    29701 ttgggctgcc ttcaagatgg cttggtaaat cttatctgga ttaaattcag caatttcgcc
    29761 attacgtttg attacttgca taggtttctc ctttattctt tgttttcttt gatttctgcc
    29821 agcatttttt cttcttctac tgtcagttga taatgttcaa gtaaatccgg tctgcgctcg
    29881 taggttttct ttaaactctc gtacaatcgc cactgacgaa tcttttcatg atggccactc
    29941 atcaatacat ctggcacgac catgcctcga taatcatagg gacgtgtgta ctgaggatat
    30001 tctaaaagac ctgaagaaaa actatcatct tggtggctag actccttgcc aatcacttct
    30061 ggaatcaggc gaactgtagc atcaatcatg gtcatagctg ccaattctcc accagtgagg
    30121 acatagtcgc ccagggaaat ctcatctgtt accaaggtct taatgcgctc atcataaccc
    30181 tcatagtgcc cacagataaa gattagctct tcctcttgag ccaaatcttc agcataagcc
    30241 tgatcaaact gctttccagc aggatcgagg agaataacgc gcggattttt cttttcaata
    30301 gcatcaaagg aatcgaaaat aggttgtgct ctgagcaaca tgccctgacc gcctccgtag
    30361 ggctcatcat ctacatgacg ggccttttca gcattttctc gaaaattatg atactggata
    30421 tccaagagcc ctttttctcg agcctttcca acgattgagt gctccagtgg agaaaacatc
    30481 tctggaaaga gggttaaaat atcaatcttc atcgtctaac ccttctaaga tttccacatc
    30541 gacccgttta tttggaatat caacattgag aaccactggt gggatataag gtaaaagcaa
    30601 atcacgtttg ccttttcgtt tgaccaccca gacatcatta gcacctggtt gcaggatttc
    30661 cttgatggtt ccaaccaagc tatcaccctc atagacttcc aaaccgataa tctcgtgata
    30721 gtaaaattca ccatcgtcta ggtcattcaa atcttcctca gcgaccttga gactgtatcc
    30781 cttgtacttt tcgatagtat tgatatggta catatctttg aatttaataa tgtcaaagtt
    30841 cttctgttta cggtggctag cgatggtcac tgtttggaca aactgatctt tttcatcaaa
    30901 caaagccagc tcagctcctt ttttaaaccg ttcttctgca aaatccgtca cagacaagac
    30961 tcgcatctca ccctgtaatc cctgcgtatt aacgattttc ccaacattaa agtagttcat
    31021 cttgtctcct gtaatctcct tttttccatc ttattctgac aattctcgaa taatagccgc
    31081 aattttttcc gattctgacc attgtaaata atggtgattc cctcctaaaa tgagtttagt
    31141 attggaagtc caatattctg attctctgta ctctttttct ctataagtct gacaaaaaat
    31201 aaatataggg acatgagatt ctatcgacaa attctcaaaa tcttcctcag taatctctcc
    31261 agatatctga aattctggat cttgattttc caactctaag cctttttctt gcattaattc
    31321 ccagattttt ttattcgttt caggactaaa tgttgcttga gttaagttct taaaataaag
    31381 ttcaggacca cactcgtcaa tcagcctcat ctgctcttcc atttctggat aaggattttc
    31441 tgaaaaatca gcaaacatga cttttttagt tgtcggttca attgctacta aagtctgaca
    31501 cttaattggt ttctcgagta atttgcaagc taaaattcca ctccaactat gtacacaaag
    31561 tatatattca gaaatcccta attcttcaag tgcttcataa accacatctg caagattatc
    31621 tagatttttt ccagcttggt cataaatcgg actcctacct gtgttcggaa aatcaattgt
    31681 caaataacca attgtaggag gaggtttttc aagtataagt gaaaaatttt cataacttgg
    31741 tagcaaacct gctccattta gacaaactag cactttcttt tgcttttgat aagcaacaga
    31801 gagactacca atttctgtag atacttcaaa cctcttcata aagaaatcca ctgattctat
    31861 ataatgaatt attaaaaatc cttatccttt attttatcac gttccaagga ttttctcaag
    31921 ttggaggaag gggacaacat ctctactttc ccttcaagaa tccttccaaa tcatgtttat
    31981 gttggtaatt aacggctgcg gttttgtctt tctcaaagat ggttctagtt aggtcaatat
    32041 gcttgatagc agcaatagcg acggtgtaga gaatgatatc agccagttct ctggcaagtt
    32101 cctcgttcga atcctatccc ttcttttcga ccagagcgcc tattcaaaac ctcggctact
    32161 tctccgactt cctccactaa cttcataaag agaccttcat cagtccgaga ctgctgttaa
    32221 tgttcgagta agtagtcttg gaattgccta aacgttcaat cttttatagt atattgaaac
    32281 tagaatagta cacctttact tctaaaacat tgttagaaat cgatttgact gtcctgatcg
    32341 atttgtcctg ttattatttc attttactat atcttctatt ccacacaaaa aagcgagaca
    32401 tccgtcccgc ccttcttatt tttcgtcaat aacgattctt acttttttgt attcagttgg
    32461 gacagagtag acaatcgttc ttatcgcaga aatagtgcga cccttacgac cgattacacg
    32521 acccacatcg ctttgatcaa gattcaaatg atattccaaa aattctggtg tatcctcaat
    32581 cttgatagtt aaggcatctg gttgtgaaat taagggtttc acaatcgcaa taatgagatt
    32641 ttcaatcgta tccatctgtc aacctacttt aaacttattt tgaaaattta gaatcgtgga
    32701 attttttcaa tacgccttct tttgaaagga tgttacgtac tgtgtctgaa ggttgagctc
    32761 cattagccaa ccatgtaaga acgcggtctt ctttcaaagt tacttggttt tcagcaacaa
    32821 gtgggttgta agttccaact gtttcgatga aacgtccgtc acgtggtgaa cgtgaatctg
    32881 ctacgttgat acggtagaaa ggttttttct tagaacccat acgagtcaaa cggattttaa
    32941 ctgccatttt taaagtctca tttctttaat tttttatttc ggtgaaatag ctgagctatt
    33001 tagcacatgt tctattatag cagatttctg gcaggtgtca agaaaaaaac ttgacagact
    33061 ataaatttct taaagcattt aaaaatttgt tagaatagga aataaatgtt tgaaagatgc
    33121 tatccgtgaa tactatttta gaaaaatttt ataaagaaca ccaagtcaaa cccttcatat
    33181 cgcctgaacg agatttggat acttggcttc taagtcccaa gcccgttccc aagcgaaata
    33241 tggacttatt agtagatgat tcactagcag gagatatcat tttactatgg agaatccagt
    33301 ttggtacttt taccactgaa acatgatttt aaaaactccc attcgaatat gattcaaaat
    33361 tcgcttagaa tcaatgtttt cccacttttt caaaaaataa attttcatct aatttaaata
    33421 actttcaatt aagtgtgaat tttgcttaaa atcattaaaa aacaccccat ggtgtgaacc
    33481 atgaagtgtt gtaaatgctg tgttgtagct agttcttagc gtttagagaa ctggctagct
    33541 ttacgagctt tcttaagatc tggtttccaa aatactttga gtacacttat ggtattgatg
    33601 cccctaaaca tctaaaaact ctggtagaaa aagggtatgc tcttgtcgaa acttcttttg
    33661 actcacttga ccatctaaat aataccatga aaaagaatat cctgaagaag aagggagtta
    33721 ctggactttc taaaatgaaa tcttgcgacc tggatcaagc ccttcatgag tatttttcag
    33781 aagaagaatt agctggtcac tttcatgtcc ttctatggac ttttttacaa tggcattgct
    33841 atcacaccca atacctatct aagcgcctgg ttcgtaaact ttattgcagc tcttcctcta
    33901 aatttcctaa ttgttgaacc aattgcccgt tttatactaa gttcttttca gaaaccattt
    33961 actggggaag aagttgaaga agttgaagat ttttaagatg atgatgaaat cccaactatt
    34021 atctaagcca gttctgtaaa ctactaatat ttgaaatcca cttcctttta gggtacaatg
    34081 gttataaatg aatttttgag aggaacagaa tgaaaaaact agcaaccctt cttttactgt
    34141 ctactgtagc cctagctggg tgtagcagcg tccaacgcag tctgcgtggt gatgattatg
    34201 ttgattccag tcttgctgct gaagaaagtt ccaaagtagc tgcccaatct gccaaggagt
    34261 taaacgatgc tttaacaaac gaaaacgcca atttcccaca actatctaag gaagttgctg
    34321 aagatgaagc cgaagtgatt ctccacacaa gccaaggtga tattcgcatt aaactcttcc
    34381 ctaaactcgc tcctctagcg gttgaaaatt tcctcactca cgccaaagaa ggctactata
    34441 acggtattac cttccaccgt gtcatcgatg gctttatggt ccaaactgga gatccaaaag
    34501 gggacggtac aggtggtcag tccatctggc atgacaagga taagactaaa gacaaaggaa
    34561 ctggtttcaa gaacgagatt actccttatt tgtataacat ccgcggtgct cttgctatgg
    34621 ctaatactgg tcaaccaaac accaatggca gccagttctt catcaaccaa aactctacag
    34681 atacctcttc taaactccct acaagcaagt atccacagaa aattatcgaa gcctacaaag
    34741 aaggtggaaa ccctagtcta gatggcaaac atccagtctt tggtcaagtg attggcggta
    34801 tggatgttgt ggataagatt gctaaagccg aaaaagatga aaaagacaag ccaactactg
    34861 ctatcacaat cgacagcatc gaagtggtga aagactacga ttttaaatct taaaaaccaa
    34921 aagaaataca gtatccacat tcggtactgt atttctttta ctctcattct taagttaaat
    34981 tattaaaatc ccatatttgg tctatccaac cttcataaaa gtctggatcg tggcagacca
    35041 taaggataga tcccctgtat tctttgagag cgcgtttgag ctcatccttt gcatccacat
    35101 ccaaatggtt ggtcggctcg tccagcacta aaacgttgtt ttcacgattc atcaagagac
    35161 agaaacgaac cttggcttgc tctccccctg ataatacttg aatctggctt tcaatatgtt
    35221 tggttgtcaa accacaacgg gcaagggctg cacggacttc tgcttgatta agggcaggaa
    35281 aggcattcca gacagcttca agaggagttt ggcgattacc gccttctact tcctgctcaa
    35341 aataaccaag ttctaaataa tctccacgct ccacttcccc agcgattggc gagataatgc
    35401 ccaagagact cttcaagaga gttgtttttc caataccatt agcaccaata atcgcaacct
    35461 tttgattgcg ttcgaaggta agatttaaag gcttagtaag aggacggtcg taaccaattt
    35521 gcaagttctt ggcttggaag ataaagcgcc ctggtgtacg agctggtttg aaatcaaagg
    35581 atggttttgg tttctcactt tggagttcga taatatccat cttatccaat ttcttttgac
    35641 gagacatagc catattacga gttgcaacac gggctttatt acgagccaca aagtccttga
    35701 ggtctgcaat ctctttctgc tggcgttcgt aggctgcctc tagctgagat ttcttcatag
    35761 cataaacttc ttggaactgg tagtagtcac cagagtaacg cgtcagctgt tgattttcca
    35821 catgatagac aatattaata acgtcattga ggaatggaat atcgtgcgaa atgagaacaa
    35881 aggcattctc atagttttgg agatagcgct tgagccaatc aatatgctca gcatccaagt
    35941 agttggtcgg ctcgtccaac agcaaaatat caggcttttc aaggagaagt tttgccaaaa
    36001 gcaccttggt tctttgccca cctgacaaag aagttacatc cgtatccatg ccaaagtcca
    36061 taataccaag agcacgcgct acttcgtcaa tcttagcatc caaggtatag aaatcacgac
    36121 tctccagacg gtcttgaagt tctcctactt cttccatgag agcatcaaca tccgcgccgt
    36181 cttcagccat tttcatatag aggtcattga tacgagcttc agctttgaaa agctcatcaa
    36241 aagccgtacg gagaacatca cgcaccgact gtctttcagc aaggacagag tgctgatcca
    36301 agtaaccagc cgtcacatat ttggaccact caacctttcc ttcatctggc agcattttac
    36361 cagtcacgat actcataaag gttgattttc cttcaccatt ggcaccgacc aggccgatat
    36421 gttctccctt gaggagacgg aaggacacat cttcaaaaat tgcacggtca ccaaaaccgt
    36481 gactcagatt tttaacttct aaaatactca ttttaattcc ttaccttgtt tttatgtaat
    36541 cgtttataaa ggagccaagc cagatagcca cccaaagtgt tggtccacaa atcatcaatc
    36601 tcaaagacgc gattgaaatc aaagaaaaag tccaagatta attgcgtaca ctcgattcca
    36661 agactcacaa gaaaactaaa aagaaggacc ttttttgttt tccgcaaatt tggaaataga
    36721 taaaggagtt ggaaaatcag aggaaaaaac aagaagacat tgaggatatt ttgtaaaaaa
    36781 atccaacata attgtccaat gtcactcact tcgcccagtt tccagagaga attgaaagga
    36841 gtcaaaagaa aaaccaggcg tccaagatgc tgaatacctg gagttcccac tcccacggta
    36901 gattgttctt gaggagtaaa gcaaaaacag acaatgcaaa tgctatagaa aatgactccc
    36961 cagaccaaaa tatgattata agtcttcttc accattaagg atttaccgct gcgactgcct
    37021 tctggcggtc acgtttcatt gtgttagagc gcaattgtcc acaagctgcg tcaatatctg
    37081 taccatgctc ttgacgaacc acacagttga cccctttttt cttaagcgta tcatagaaag
    37141 ccaacacgcg ctctttggga ctacggctat attggtcatg ctcactaact gggttataag
    37201 gaatcaagtt tacataagac aatttcttga tgttcttgag caattcagtc aattccaagg
    37261 cttgttctac accgtcgttg acttcattaa gcatgatata ttcaaaggtt acacgacggt
    37321 ttgttgtctc aatgtagtat tcaatagcag caaagagttt ttcaatcgga aaggcacggt
    37381 taatcttcat gatacttgaa cgaagttcat tgttaggtgc gtgaagagac acggcaagat
    37441 tgacctgaac cccttcatca gcaaagtcac gaattttatg agccaaacct gaggttgaaa
    37501 ccgtgatgtg acgagcaccg atagccattc ctttatcatc attgatagta cgaaagaaat
    37561 tcaagacatt gttgtaatta tcaaagggct caccgattcc catgacaacg atatggctga
    37621 cgcgttcatc ctgaccacgc tcatcaaagt atttctgaac cagcatgatt tgcgctacga
    37681 tttcaccgtt attgaggtca cgttgcttct taatcaaacc agaggaacag aaggtacaac
    37741 cgatattaca gccgacctga gtggtcacac agacagataa accatagtgt tgacacatga
    37801 gtacagtctc aattaacata ccgtcaggca attcaaagag atatttgact gtaccatcag
    37861 cagactcttg cacaatacgt tgtttcaagg gattgaccac aaactggtca ttgagcttag
    37921 caatcaaatc cttggaaagg ttggtcattt cttcaaatga ctgcacacgt ttacggtaga
    37981 gccattccca gatttgatct gcacggaatt tcttttctcc ctgctccaat acccattcct
    38041 gcatggtttg atgtgccaaa ctatgaattg agggtttcat ttcttctcct tattctctac
    38101 tcacttctga cgaatgacaa aatgacgttg ttccttgtcc tctttctgag aatgctggtc
    38161 tttctgacga cgtctatttt tcttatctgc attcgacttt cgtttagttt gagtcggttt
    38221 ctttcctttt ctagaaggtg tttcttcttc cgtcttacgc attttcttgt caaatgatgc
    38281 tcgcttaggg gcttcatttt ctaagacaaa ataggcacaa ccataactac aatactctaa
    38341 aaggtagtct tgtaaacgac tgattttttc aagtttttct tctgttcggt catccttgta
    38401 aaaacctcgt aggcgaagct gttcgttgct ccagtccccc acgatataat caaacttggt
    38461 taatacttct gaaaaacgct gattaaaagt cgtcacatca aaggcatcct tgatattttc
    38521 aaccaaggaa aaagctatcc cttccgtttc gaccttgtcc ccgtgtaaat ggaactccgg
    38581 accaggaaac ttgttatagt tgtataattc aggtgcaatt tcttttcgca tagatatcct
    38641 ttttccacga ttacttaata ctttattcta ccataatttc tagcagttag cacgtttctc
    38701 ataaaaatga aaaaagtctg acgattttgt cagaccagaa tcttataacc taaaaaagag
    38761 aagaacaatt cttccctcca actatcatta tttagcagct gcgtacaatt catctacttt
    38821 attccagttg attactgaaa agaaagcttt gatatagtca ggacgcacgt tgcggtattt
    38881 cacgtagtaa gcatgttccc aaacgtccaa gcccaagatt ggttttttac cttctgagat
    38941 tggtgtgtct tggtttgctg ttgaagtcac ttcaagtttc ccttctttgt tgacaaccaa
    39001 ccatgcccaa cctgaaccaa aacgagttgt tgctgctgca gtgaaggctg cttggaattc
    39061 ttcaaatgaa ccaaatgttg catcgattgc tgctgccagt tctgctgaag gagctgtttt
    39121 ctcgggagtc atcaattccc agaaaagagc gtggttcaag tgtccgccac cattgttgat
    39181 aagtgcttga cggatatcag ctggaataga ttctacatca gcaagcaagg cttcaaggtc
    39241 ttcaccgatt tcagggtgtt tttctaaagc tgcattggca ttgttgacat aagtttgatg
    39301 gtgtttgtca tggtgcaaat gcattgtttc cgcatcgatg tatggttcca aagcgtcgta
    39361 tgcatatgga agttctggta agataatagc catctgtaat acctcttttt ctttctatat
    39421 gaaaatgata acgcaaacat tcactttttt caagtttttt gcttatagat aaggaaatca
    39481 ctgacatact ttctaataaa ataagcaaat cagcaagaaa cccacgacaa gataatcctg
    39541 acgtgggttg tagtttcaac aaatgtcaat tgacctgact agcaatctgt aagagtgcct
    39601 tttcaaaaag gaaacctttt tcataaagac ctgtcttaat ctgatagtct gtctcaatca
    39661 aataggaaat agcttgcttc agaaagctca aagaaagtcc tctcgaatct cttaatgcaa
    39721 acttgatttg ataaggattt gggttacgtc ccagataact acctaaacta cttgcaatct
    39781 gcgattctgt ttggccagac tccgccaaaa tcttcacctg agtaaaagtc cgaaattgtc
    39841 ccagcatgac tgcaatcagc ttgatttcat cttccccttg caaggtcaag tctctcacca
    39901 aatcgcgcgc ctgatccatc tttttagtta gaataaactg agttaaatca aaaatattgt
    39961 cctgcaaggt cttgggaatt acgttaacaa tatcctcttc ctcgataaca gaatccgcct
    40021 tataggactg taaaaagaga agatttttct ggatttcgct aaattgaaac cccgacttga
    40081 tgaggagatt ttcaaaagaa tgattggtaa actgcagacc ttgtttctga ctccactttt
    40141 ggaaatactg gcgcaattct tgttctttta cttctactgc atcgaagacc ttggcatcac
    40201 gcttaagtaa tttgactaac cgtcttttgc tatccagctt tccttctgca aagattatca
    40261 acttagttgt tggagaagga ttgtcaaggt attcctcaaa tgacttaagc tcatcatctg
    40321 tcaaaaagcg tttcttagca gtcgtgatat ccataaaata atctaatatc acgattttct
    40381 catccgcaaa gaaaggaagg ctgaccaact ccaattccac atccttgtaa actacttctt
    40441 tcatatcaaa gtaggcaaag ttgaggtcag cagaatcata cccaatctgt ttcaacactt
    40501 gactcttcat cacttcaaac tgaccctgat ctgtccctgt aaataggctc aggctcggta
    40561 aatttgataa agtcaacttc tgactttctt caatggctag catcgtctct cctttcttct
    40621 gatttttcga tttaatttag tcaatatagc gcaatttccc acggaaatct tctaagctct
    40681 cgtagccttt ttccaccatg attgctttca gttcattggt aatgcggtca aaagcactga
    40741 cgccttcttt gtgaagggtc gttcccacct gcaccatact tgctccacag aggatgtgtt
    40801 caaaggcatc tcgaccagtc agaacgccac ctgttccgat aatttggatt tgaggattta
    40861 aacgttgata aaaggcgtga acattggcta gagcagtcgg tttgatgtat tctccaccaa
    40921 ttccaccaaa accattctta ggccgaataa cgacagattc gtcttctata tagaggccgt
    40981 ttccgataga gttaacgcag ttgacaaact tgagcggata tttgttgaaa atagctgccg
    41041 cttggtcaaa gtgaacaata tcaaaataag gtggcaattt aattccaaga ggtttggtga
    41101 agtaagcaaa cacttctgcc aaaatccggt ctgttgtctc aaaatcatag gcaatctgag
    41161 gtttacctgg aacatttgga caggaaagat ttagctcagt cagaccacga aaatcactct
    41221 cttggacttt tttcaaaata gtatgggttt cctctggaga catgccgacc agagataaga
    41281 agaaagttcg gttcgactct ttttcctgca aatctaaaag ataatccaaa taatagtcta
    41341 agccattatt tggcaagccc atagagttga tggaaccaag tggaacatct tggtagcgtg
    41401 gctcaggatt cccctgacgg aagtccaagg tcgctgtctt agtaacaaag gttcctgccg
    41461 ctgagttttt gacctcttct aactcctcta tcgtcataca agccacacct gctgcattca
    41521 tcaagcaatt gtcaaactca aaaccagcaa tttgtgtttt cgttgatacc atgattctaa
    41581 tcctccagat ttcttttatt gctaatatta taccataatt ttaattctag gtttactaga
    41641 ttctgtggtt ctatctattt attcggaaaa gaaagtctag tacagaagtc atgctatgga
    41701 aacagctagt gtattggaag tttgaacaag gcttgggtaa cagacttttg aatgaagtcc
    41761 aagcaacaag gagaaatctc aaccatgagt ccattccatg actctgttgc tctagaaaac
    41821 cttgcaatag tcaagtgata acgaataaaa ctttggattg aaatatcccc atgattatct
    41881 attacgagga gaaatctcaa cctttatcat ttttaaagaa atatagtaaa atgaaacaag
    41941 aacaggagaa atcgatcagg acagtcaaat cgatttctaa caatgtttta gaagttgaag
    42001 tgtactattc tagtttcaat ctactataca tgtaaatctc tactttcgca aaatggattt
    42061 tcagaacagt atcccaatat agttaaaaac tataaaaaag agaggacgtt cccctcttaa
    42121 aatcttattt tactgcttct ttcaaagcat ctaccttatc caaacgttcc catggaagat
    42181 caatatctgt acgtcccatg tgaccgtaag ccgatgtttg acggtaaatt ggacgcttaa
    42241 ggtccagcat ttggataatc cctgcagggc gaaggtcaaa gatttgacga gccgcttttt
    42301 caagttgact ttcagctact gttcctgtac cgaaagtatc gatacgaaca gaaacaggtt
    42361 gcgcaacacc gatagcatag gccaactgca cttctgcctt cttagcaagg cctgctgcaa
    42421 cgatattctt ggcaatatag cgagccgcat aagaggctga acgatccacc ttagtcgcat
    42481 ctttaccaga gaaggcacca ccaccatgac gagagtagcc accataagta tctacaataa
    42541 tcttacgacc agtcaaacct gagtcccctt gaggaccacc gattacaaaa cgacctgtcg
    42601 gattgataaa gaattttgtc ttatcatcaa gataagaaga tggaataact tctttgatga
    42661 ccttgtcaat cacatcttga tggatttgtt cattagtggc ctctggatca tgctgagtag
    42721 aaataacgac tgtatctaca cgtaccggac ggtcattttc atcgtactca actgtaactt
    42781 gtgattttgc atctggacgg agatagctaa tttctccaga cttacgaagt tctgccagac
    42841 gacgaaccaa tttatgactg agtgcaattg gcaatggcat aagctcttct gtttcatcta
    42901 ctgcaaatcc aaacatgagc ccttggtcac ctgctccaat caagtccagt ggatcttgat
    42961 cagcatttcc acgaacctcc aaggcttcgt taacaccttg agcgatgtca ggagattgtt
    43021 ccaccaaaga tgggtgtact cccaccgtct cagcagaaaa tccatattct gtattggtat
    43081 aaccaatctc tgcaatggta tcacgaacca cacggttaat atccacatag gcatttgtag
    43141 aaatttcacc aaaaacgtgg acagaaccag tatatacagc tgtttcagca gcaacgtgcg
    43201 cctctggatc ctttgctaaa atagcatcca aaatcgcatc tgaaatttgg tctgcaatct
    43261 tatccggatg cccctcagat acagattcag acgtgaataa tttacgttct gacataaaaa
    43321 tgtcccccct taaaaaatat tgttatagag ttacaaagta ctgataggaa tttccattat
    43381 ctaagagtta ctagcttcag aaataaaaac gatacttttt tatttctgaa gctagtaagg
    43441 cgcatagggt gaccgcagta tggcggcaac cgtagaaaga cgagcgacct cgaagccgtc
    43501 attctttgcg aattgcaaac tactgatagg aaaactcttc gtaataaata cctaccatct
    43561 tatcgggact atataacttt atcattatac catttttaat cgcaatttgc agtctttaat
    43621 gtagtgtttc ggtttagata gttcgttctc ataaataaaa aagttggagc tcagtactcc
    43681 aacaatttct attaaaatgt ttggcgttta gctttacgct ctgcacgacc gcgagcgcga
    43741 ttttcagcac gcttagtttt acggcgcttt tcatcaaccg cccattgaat tttcttctta
    43801 taacccggtt tgactttttt ctttttcttt ttaaccaaac caatcatttc gatatcaagt
    43861 ttatcttgtt ttttctcacg gttggcacga cgatcacggt cataggtatc ttgaaattcc
    43921 ccatctttga ccatcttagg actaaacttg attcccaatt tctccaactc acggatatcc
    43981 gagtcatcac ttggctgata aagggtaata gctgtacctg gtaggccatt tcgtccagta
    44041 cgaccaacac ggtgaacaaa aaaagataag tcttgcggaa tggcatcatt gatgacatgg
    44101 ctgacacctt caatgtcaat cccacgcgct gctaaatctg ttgcgacaat atactcaaaa
    44161 tccagatttt gcacctgatt catgattcgc ttgcgttcac gaggggcaat atctccatgg
    44221 atttttgcaa ccttcaagcc ttgagcagtc agatatgaat gcaattcatc agcacgcgtt
    44281 ttagtgttaa caaaaatcat tgccaaatac ggctgcatca actgagtcaa ttggtaaatt
    44341 tgagcattct tatcatgtcc cttggtcgaa atcaaccaat tatcaatggt gtcagaaata
    44401 accgttttag tcttaatttt ctccataaca ggatttgata agtatttttt caagaatggt
    44461 tgcagttttt gtgggatagt cgctgagaag accatgaatt gcaagtcttt tggaagactg
    44521 ccagcaatct tatcaacaat ttccaagaat cccatatcca aggtcatatc tgcttcatca
    44581 acaacaaatg tcttggcttt atgaatagct aaatcaccag atttaaccaa gtcgtagata
    44641 cggcctggtg ttccaataac aatatgaggc tgattgcttg ccaatttctc aatctggcga
    44701 gccttatccg taccacccac ataattaacc acacgaactt cgacatctga gtgagctgaa
    44761 atctgacgcg ctacttggta aatttgagta gccaactcac gactcggtgc agtaatcact
    44821 gcttgtacac tatcgctagc ttcatctaat tgctggaaaa tcggtaacaa gaaagtatga
    44881 gtcttacctg aacctgtttt tgattctcct actaggtcac gacctgccaa aacaatagga
    44941 atcaacttat cttgcacctc tgttggagtt gtaaatttta actccttcaa ggcttctcta
    45001 atatagtttt taaattgaaa tttcgtaaat gacataacat cctcgattct atctatctta
    45061 tcaattatac catattttat tccattacag tagtctcact tatttaggct atttccagta
    45121 gcttctctag taagaaaagg ctagaatttt atagttccaa cctcttttca gttattattt
    45181 ccagtttaat atagcattca agccatagtg atcactcact tgtggactct tgttaccatc
    45241 aaatacgaca tgtaaatttt ccaccgctaa ctctttggta gtaaagacat aatcgattcg
    45301 aaggggttca gtgttctctt tccagccatc aatttcaggc ggaacagtat agctaccact
    45361 tttctcttga gcaacttcaa atgcgtcttg taagcctaat ggactagcta aaatagcttg
    45421 gtaaccttcc tgacctgctg ggttgttaaa atctccagct agtaaaagtg gcttgttcaa
    45481 ttttttcaag acagcctcaa atcgtgccca ttcttcttgg aaacctttat cccaccaaga
    45541 gagatgaaca ctggcaactg ctagctcctt gccatcgact acagtttcag ctagggcaac
    45601 acggcgagta tgatagtctg ttggatcatc cacatccgaa accaaaattt ctctggcttc
    45661 aataggtgtt ttagacaaga tagccacacc ttcatggtag cggtcatagc cgatatggtt
    45721 ataagcccag gtccagtagt aatttttccc ttgctctaac aacttttcaa ccaagagtct
    45781 aacataatgg tcttggtgaa taggctcagc tgctggcaaa gcttgataaa ggtcattaac
    45841 ctccacctct gacgaggtca tctcctgatt gatttcttgg aaacaaatca aatcatagtc
    45901 cttttcaaga atatcttcaa gcaaaatctg gaatttttcc tctgcttctt tctccatcca
    45961 actgtgagta ttgagtgtta aaaatttcat tcttttctcc caaaataaga ggttggaata
    46021 cagcttccaa cctcaagtat attacaattc tactttagca actgctgttt tagctgcaag
    46081 agaacctgtt ttttctaatt taactgattt aattgcatca ccatttgtga agacaactac
    46141 tgttgaagtt tcacgtcctg ctgcacggat agcatccaag tcagctgtga caaggagatc
    46201 tcctgctgca actttttgtc cttcagcaac atgaactgta aatggtttac cttcaagact
    46261 tactgtgtcc aaaccaatgt gaaccaatac ttcaagacct gcttccgtca caataccaaa
    46321 agcatgtttt gttgggaaga tgcttgatac agtacctgaa actggagata caatgtttcc
    46381 atttgcaggt tctactgcaa atccatcacc catcattttt tgagcaaata ctggatcctt
    46441 tacttgttcc aaagcaacaa cttgaccgtc tgctactgag taaacttcct cagtaagatc
    46501 tttgaagtga acagtgtttt gttgtgcttc agtcatttgg cttggaagag tttcaggaat
    46561 gatttcacct gaatcaagga tatcttggat atcagatttc aaaatgtcag cttttggacc
    46621 gtagatagct tgaacccctt gtcctttcat cacaagaccc atagctcctt ctgctttcca
    46681 ttgctctgca tttcctactt tatctgcatc tttaacagtt acacgaagac gagtcataca
    46741 tgcatcaaca tcaacgatgt ttacacgtcc accaagaagg ttgataatgt ttacagcttg
    46801 agagcctgct gcaactttca cttcgctgct ggtttcttct gaaccttcag cagtttcgta
    46861 gtttccgttg cgccctggag ttgcgtagtt gaatttttga atcatgaagt ttgcgataaa
    46921 gtacatgatt acagcaaaga gaacagttac ccaaacgaag ttaacgatat ccataccaat
    46981 accagcactg attgcaatag gtgtacgagt caagaactcg attgaaccga atgagtgcat
    47041 acgtaggttt acgacgtcag ccatagcgaa ggcagcacct tgaacaagtg agtaaacaag
    47101 atacataggt gttgcgatga acatgaacat gtattcgatt ggttcagtaa cccctgtcaa
    47161 gaatgttgca agagctgttg caatcatcat acctttgtat ttatgtttct tgtcagcatc
    47221 aacattacgg tagatagcaa caatcacacc catcaagata ccgaatgaac cgatcatttg
    47281 tccaactttg aaacgagctg gatgtactgt atctaacaag tgttggtatt gactagcatc
    47341 agtaccttta aggtttacaa ggtctgttac ccatgcaagc catagtgggt cttgaccgaa
    47401 tacttgagta cctttagctg caccagttaa aatgtcataa gtaccaccaa gagctgtgta
    47461 gttcattggg atagtcaaca tgtggtgaag accaaatggc aagagcaaac gttccaaagt
    47521 accatacaag aatggtgcaa gaattggagc agtttcttgt gagttggcaa tccagatacc
    47581 gaagttattg atacctgttt gaactactgg ccagaaagca gcaagtagaa ttgcagcgat
    47641 tgctgaacga agaataacta caaatggtac gaaacgtttc ccgttgaaga atgaaagtgc
    47701 atcaggaagt ttacggaagt tgtagtattt gttgtaagca gttgccccta caaaacctga
    47761 gataatccct acgaataccc ccatgttcaa ggctggagct tcaagaacac tgataaagta
    47821 atcagcaact ttgattgaac caccaaagaa agtagttacc atagcatctg gatttttcaa
    47881 catatcgcct gacacaccaa agattgtacc agtgatacgg ttaatcaaga taaaggcaag
    47941 accagcggcg aaagcaccac cagcacgttc tttagcccag cttcctccaa tggctagggc
    48001 aaacaaaatg tgaaggttac cgataacccc ccaaccgatt tgctcaagaa ttccacctgt
    48061 gatgacaagt ggtgtaaagg ttgggttaat catcacgata gacttaccga ttgaaatcat
    48121 caaaccagca gccggcataa ccgcgataac taccatcaaa gccttaccga atttttgcca
    48181 aaattcgaaa gacaagacat ttttgaatgt atctttcatc attcaaatct cctttatttt
    48241 tatttaggca aacgctttac gaaaacgttt gcaccttcta tgatttaatt ataccacttt
    48301 aatttttttt gtaaaggctt ttataaaaaa attacacttt tttctaaaaa atttctagtg
    48361 cgccaaattt caagttcaaa ttagccatca agaagtcttc tctgggggac ttctttggaa
    48421 gctcttttct tctacgcatc tcttttcaaa aactcttgta gcaaaaaagg agattttaca
    48481 atctcctcat aaaagcagct attttaccta aatcttcaag aatcggcgca tggatattcc
    48541 tgatcccaat gaaccaatga aaaccccaat cacaaatagt agggcaatca tcaacggact
    48601 aaataaatct ggactaatca tggatagatt ttgccctacc aacgatttgt tgacagattg
    48661 gtaaacaatt tgataaacaa taaagaccaa aacagatggt gcgatagctc ccaataaacc
    48721 gataaaggct ccttctaaca agaacggtcc acggatataa ctgtttttag ctccgaccaa
    48781 gcgcatgatt tgaatttcgc gactgcggga aataatggta atacgaatgg tatttgaaat
    48841 caagaaaact gcgataaaaa ttaacaaagc agcaatccct agtccccaaa cacggataaa
    48901 tgaagctaac ttgaagagtc tttctgtatt ggcaccgcca tcttgaacct cagagacacc
    48961 ttcaattttt ttagcatctt cggctatagt ttttacatca tttggagcgt ttgcctctac
    49021 aatataggca tcatagagag gattggcatc tccttcaaag attttccagt tatctcccat
    49081 tatctcggtt aatttttcat attgttcttc tttacttgaa aaggtaacac ttttaaccgt
    49141 agacatgttc ttcaaagaat catatacctt gtggtagtca ttatttgtaa cagtttgacc
    49201 ttctttttca attgtctgac tattatcttc cacatccttt cggatataaa ctactacacg
    49261 gacattattt tcaatatctg tagctagttt cgctgtattg aaaataacag atgcaaatat
    49321 tgccaccaag gtcaaagtaa tcatgactga actgacagca gctactgtca tccaaccatt
    49381 tcgtttcaaa ctttttaagg cttcaaataa atggcgaaaa aatctactaa tcatcgtatc
    49441 catactctcc ttttgattcg tcacgaacga cacggccatt ttcaatggca atgacacggt
    49501 ggcgcaaggt atttacaatc tggctattat gagtcgccat caaaatagtt gtcccttgta
    49561 ggttaatccg ttccaagaga ttcataattt cccatgaatt atccggatcc agatttcctg
    49621 ttggctcatc agctatcaat actttgggat tatttacaat tgcacgcgca atcgcaatcc
    49681 gctgttgctc cccacctgag agttcatttg ggaaagaacg aaccttatgc ttcaatccaa
    49741 ccaagtccaa aacttccatc actcgttttt tgatattacg gcgattttcc ccgattactt
    49801 ccatagcgta agcaatattt tcatagacag ttttctttgg taacaattta taatcctgga
    49861 agacaacccc aacactacga cgtagaagcg ggacatcttt ctttttgatc ttaaccagat
    49921 taaaaccagc aactgatagg cttcctttat cgatttttac ttcacgatac agagaacgaa
    49981 taaaagttga cttccctgct cctgaaggtc ctacgatgta agcaaattcc cccggttgaa
    50041 cgctgaccga aacaccgcgt agagcagtcg ttccgttgtc gtatttttta acgacatctc
    50101 tcatttcaat aattgacatg tgagttcctt tctatcttag ctaattcgcc acttgagata
    50161 agcatcgata aaaccatcta ggtccccatc cataacctta tctacctgag caacctcaaa
    50221 gctagttcgg tgatctttta ccatagtata aggcgtgaag acataagaac ggatttggct
    50281 tccccaagtg atctcctttt tctcaccttt gagagaatct acctccgcag ccttcttatc
    50341 ttgctccatt tgatagagct tagcctgcaa catcttcatg gcacgatctc tatttccata
    50401 ctgggtacga tccactgttg attggacaac aattccagtt ggaatgtggg ttaaacgtac
    50461 acctgttgaa actttattga cgttttgtcc accggcacca cctgaacgga aggtatccat
    50521 cttgatatca tcttcacgga tttccacttc aatagtatca tccaattctg gcatcacttc
    50581 tacagatgtg aaagaggtat ggcgacgttt ggcagagtca aatggtgaga ttcgcactaa
    50641 gcgatgaaca cccatttctg acttgaggag accataggca ttaggccctt caaatgataa
    50701 agttaccgac ttaataccag cctcatcacc tgcttggtaa tccaacactt ccactttaaa
    50761 gcctttagca ttaccataac gagtatacat acgaagcaac atatcacccc agtcctgcgc
    50821 ctcagtacca ccagaacctg gatggatttc caagatggca ttgttgtggt cataaggttc
    50881 tgacaagagt agagtcatct cgtagctggt cattatctta tcaagttcgg ctaactgcgc
    50941 taccagttca tcatgcactg actcgtcttc agccaaaaaa tccaataaaa tttcgacttc
    51001 atcctgcaac tcttccatct tatggaaggt attgtaagtg ttttttaatt catttaattc
    51061 ttgcgacgtt ttttgggccg caatattatc gttccaaaaa tcaggttctg tcatcttgtt
    51121 ttccaagatg gcaatctctt cctctagccc ttcgaggtca aagagacccc ctgaaagaag
    51181 ctaatttttc acgatttgcg tcaattttct gacgaattac tgaaatgtcc ataaatactc
    51241 cttttttaca ttatttcatt atagcatatt ttatcatttc tttccatctt tttctctaat
    51301 ccccttttca tgaaaaaaga agcctttggg cttcccttct tacaagactt ttgctgaagt
    51361 gcgagcgatt tcttccactt gaataccatt tgcttcaaat ttttctttca aggctggtaa
    51421 atcaattgat ccatcgattt gcacttcgat aatcacctta ccatccttac gcggaatatt
    51481 gactgtatgg gagatattca aattttcttc tacaatcaaa gaaacaattt ttccaagaac
    51541 accaacttca tcttctgtaa caaagcgtac acgaatccct tcttcgccat aacctgcaat
    51601 ttcaagaaag gcttggaaaa cgtcacggtc agtaataact ccgtatactt gatggttatc
    51661 tacgacaggg agaatactaa tcttattttt caacatcaga taagttgcat cttctagact
    51721 agcatagcct gagacagtga caacatcgcg aatcatgaca tcttttactt ttgtcttatt
    51781 cagaagataa ttcatctcat agatagaaag acttgttgct ttagatggac ttgcttgtgc
    51841 aatggttccc tcagtcacca aaccaactaa ttgatcattt tcgataacag gcagacggtg
    51901 caaaccttgc tctctcatca aatctgctgc atgagatact gttgtatctg gactaatata
    51961 aactaccttg cgggtcataa aatctttaac tgccatgaga cttctccttt tctattctta
    52021 tccctattat acaatctttt tgcaaatcta tcaaacgctt acatttcttt ttcgaaattc
    52081 agaaaagtat gaataagcta gcaaaaagag ctctgaaata gagctctgtg aatgaaggta
    52141 agaaattttt cattcgattt tttcaattat tagaaattaa gctttcaatg tagatgcata
    52201 tttgtttgca atctcaatct accgactaaa aaggtccccc ggactatatt gatgattact
    52261 tcgtaatctc catctgccgg ctaaaacaat cctctggatt gttttagcca cctagatatg
    52321 cttttctgac ttcttctgat gaagcgagtt cttttcctgt ccctgatagg acgatttttc
    52381 ctgtttccaa tacatatcct cggtcagaga ttgcaagtgc tttattggca ttttgttcaa
    52441 tcaagaggac ggttgttccc tgcttctgaa tatcttgaat gatatcaaaa atctcttgga
    52501 tgaagattgg ggcaagtccc attgatggtt catctaaaag aagaagtttt ggtgttgaca
    52561 taagagcgcg tcccatggca agcatttgtt gttcccctcc tgaaagagta gctgcatctt
    52621 ggttcttccg ttcttcaaga cgaggaaagc gtgagaaaac cttcttcaag ttagcttgat
    52681 tttcttcacg atttttcttt aagaaagctc ccatttcaag attttccata acagtcaagc
    52741 caggaaagac gtggcgtcct tctggaactt gtgaaagacc acctgccacg attttctgag
    52801 ctggcatttt ttggatttct tgacctaaaa attcaatctt tcctgaactt ggtcgaacca
    52861 aacctgacaa ggtgcgaaga atagttgtct tacctgcacc attggcaccg ataagggaaa
    52921 caacttctcc tttattaact tcaaagctta catcacggac tgcttggatc ataccgtaat
    52981 gcacagaaag attttcaact tttaacatag acattaggct tcacctccta gataagcttc
    53041 gataacgcgt ttattggtct taatttcgtc tggagttcct tgagcaatta aacggccata
    53101 ttcaagtacg tagatacgtt ctgttacttc catgaccaga ttcatatcgt gttcaatcaa
    53161 catgattgta atcttaaatt catctttgat acgacgaatt aactcagtca attcggctgt
    53221 ttcctgtggg ttcatacctg ctgctggttc atctaagaag agaattttag gttccgtagc
    53281 aagggcacga acaatttcca aacgacgttg ttgtccgtag gaaagatttt tagcaagagt
    53341 ctctgcatca ccatctaaat caaagatttt caacaattcc aaagctttag cctttaattc
    53401 tttttcactc ttgtaaaaag ctggtaagcg taagaaacta gtaaaaacat gctgtttgtg
    53461 atggtttcca aaagcaatca aaacattgtc taaaactgtt aaatctttaa agagacggat
    53521 attttggaaa gtacgtccaa gtcccaaaga ggcaatctta taaggtgatt tcccattcaa
    53581 aaggtgacca tctagggtta ctgttccctc gcttggttca taaacaccgg tcaaaaggtt
    53641 gaaaagggtg gttttcccag ctccgtttgg accgattaat ccaaccagtt ccccttcgtt
    53701 caattcaaga gtcacatctc caacagctgt tagaccacca aaatgtttgg ttaactgttt
    53761 tacttcaagt aatgccatta gttttgttcc tccttcttag attttttaaa gaaacgtgat
    53821 aggctcagtt cccatgttcc aaggagtcca cctggtctga aaatcattac caataccaag
    53881 gccaaagcgt aaataatcat acgcacacta gcaacatctt ggagaagcat attcaaaatt
    53941 cccagaacaa tagccgaaac aatcgcacct gtaatggaac cgagtccacc aaatacaaca
    54001 ataatcaaaa cgttgattga gttgatgaag gtgtaatctt tcggtacaac agacccgata
    54061 aatcctgcct gaagtgaccc agcaatactt gcagtaatgg caccaaagac aaaagcgatg
    54121 attttaattt tagtcgtatt aaccccaact gactcagcag cgatttcatc ttcacgaaca
    54181 gagagggttg aacggccaat tgggctacgc aagaagttca aggttgcaat ggttgtaatc
    54241 acgacaaaga agtaaaccat ttgccaagtt gtaaagttag gaatccctaa gatacctgcc
    54301 gcaccatttg taagacttcc accattgatg ataaagatac ggataatttc agaaacaccc
    54361 agagttgcta ccgcaagata gtcccccttc aagcgcaagg ttggaatgcc gacaagtaag
    54421 gcaactactc ctgaaagcaa agcccctaca agcatagctc caaagaaggc accgtaggtt
    54481 ggtgatgtag aaccaataat agctgctgca taggcaccaa tcgccatgaa accagcatga
    54541 ccaagtgaaa attgtcctga aaaaccaacg attaagttga gaccaacagc caaaataata
    54601 ttaattccaa tttgttgtaa aatctgtaca tagaatagat taagtactcc gactgaaacc
    54661 agtacactaa tcaagctata gccagctaac aaaaggagta accatagaat attaactttt
    54721 aaattttcct tcatcgttta caccttctct ttcacattct taccaaggat accagctggg
    54781 cggacaatca agatcaacaa caagattcca taaacaatgg catcacggaa atctgacatc
    54841 ccaaaggcag tcgcaaaggt ttccaataga ccaatcacaa agccaccaag agccgcacca
    54901 ggaataattc cgataccacc aagtactgcg gcaacgaaag atttaagacc tggagtaacc
    54961 cccatcaaag gctcaagaga gttataataa agagcaatca gaacaccagc cgcacccgca
    55021 agagcagaac ccaaagcgaa ggtaaagcta atcgtacggt ttacattgat ccccatcaat
    55081 tgcgccgcgt cgctatctac tgatactgca cgcatggctt tccccatctt agtcttttgg
    55141 acaatgactt gtaacaaaat catcaaaatc aaggaaatag ccaaaatcat taactgcaca
    55201 tttgttaagc taattggtcc caaatcatat cgaactgttt gaatcgcttg agggaaggca
    55261 cgggtattgg caccaaccag atagaccatt ccatactcca ataggaaaga aaccccaata
    55321 gccgtaatca aaacagcaat acgagtagag tggcgcaaag gtcggtaagc aagaaactca
    55381 atcacgacac caagaatagc tgtcgctagc atagctacaa taagcgctac aaagaaattc
    55441 atttggaaag aattgatcaa gaaataaccg ataaaggctc ccatcatata aatatcacca
    55501 tgggcgaagt tgatgagctt gataattccg taaaccatgg tatatcctag ggctaacagc
    55561 gcgtaaacac tacctagaat caaaccattt acgagttgtt ggagcataag attcactctt
    55621 tctatttata attccgaggg gtttccctca ctttttgata ggttcttata ctcaatgaaa
    55681 atcaaagagc aaactaggaa actagccaca ggttgctcaa agcactgctt tgaggttgta
    55741 gataagactg acgaagtcag tcacatatat aatccaaggc gacgttgacg cagtttgaag
    55801 agattttcga agagtattaa atatcgaaac agggagtgag tcaaaggctc attccctatt
    55861 tcaacatttt tctattatgg ttttacaact tctgctgctt caactttacc attgttcatg
    55921 gtcatcatgt aagcagtttt gactgtgttg tggtctgcat cgaagcttgt ttgaccagtt
    55981 acaccttcaa aatcttttgt tttagcaagg ttatccttga tttcacctga atttttagca
    56041 ccttttgctg cgtttgctac aaggtgaact gaatcataag ccaaggctgc aaatgttgaa
    56101 ggctcttcat tgtacttagc acggtaagcg tcaaggaagg ctttagcttt agctgaaact
    56161 tctacagtag ttgagaagcc tgagataaag tagatgtttg atgctttttc agcagttgct
    56221 tgttgtacaa actcctcacc gttgaatcca tcaccaccaa cgattggttt gtcaattccc
    56281 atgccacgcg cttggtttac aatcttacca gcctcattat agtaaccagg aacaacgata
    56341 gcatcaaagt ctttcccttt catttttgta agggctgctt gaaagtctgt gtcacctgct
    56401 acgaaagttt catctgcaac gatttcaccc ttgtatgact cgcggaaaga tttggcaatc
    56461 cctttagcat agtcactggc attgtcagtg taaagaacaa ctttcttagc atttaatttt
    56521 tcagaaacat agtttgagat aatttttcct tggaagctat cttggaaagt tccaataaag
    56581 aggtaatctt gacctttagt caatccatct tgagtcgcac ttggtgagag caatggaaca
    56641 cctgcttttg tagcgttcgc taccgcagct gcagtcgcac cagatgtcgc aggtcctacg
    56701 actgctgata ctttagattg ggttacaagg ttagttgtaa ctgaagcagc ctcagctgtt
    56761 tcagacttat tatctttatc gactacttcg atttgttttc catcgatacc acctgcggca
    56821 ttgatttcat caacagccaa ttgggcacct ttttgttcag ctgttccgta tgcagctaaa
    56881 gaacctgatt cttcaaagtt aaacccgatt ttaattgtct tttcctctac tgagttacca
    56941 gcagtgttga ctgctccaga cttcacttct ccacaggctg caagaagtgc tacacttgca
    57001 agcgccacaa acgatagggc aaattttttc ttcatctttt tgtctcctta tttcttaaat
    57061 agtctgttaa gaatataccg aattatcaga aaattgtcaa tgttttcctt gaactttttc
    57121 gatgataacg ttttcctatc gataaagatt gcccacaaag ggtgtttcca actcttggat
    57181 atgacaaacc ctaacttttt taataaattt ttccttgctc aagcgtccga ccaattgctc
    57241 cacttcttga gttggaacat agagttgtaa gtaacgatgt ttcttggaat gataggtaat
    57301 atctccataa tcctgcagtt ttttggcatc acgattatag taaagataga taatcaagcc
    57361 agagcgattg actttttcaa acatgataaa tcctctttct aagaaatctc tccctattat
    57421 accaaaaaaa gcaaacccag tcgagtttgc cttctatcat cattagttca atgaattgtt
    57481 ggccataatt tcatcaataa agccatattc aagtgtttcc tgggcgctca tccagttatc
    57541 acgttctgca tctgcatgga ctttttccat tgactgacct gaattttcag ccaagatttt
    57601 ttccaaggta ttacgagttt tgagcaagtg ttctgcagcg atagccatat cagtttgttg
    57661 ggtaccacca cctgtaccgc ccattggttg atgaatcatg tattcagcat ttggaagcat
    57721 gaaacgtttg ccttttgctc cacttgatgc gatgactgtt cccatagatg cagccattcc
    57781 cataacaatg gtttggacat ctgccttgat aaagttcatg gtatctacga ttgccaaacc
    57841 agctgaaaca gaaccacctg gtgtattgac ataaaggtaa atatcttttg tactatcttg
    57901 ggcatccaag aaaagcaatt gggcaataac agagttagcc atattgtctt caaccggacc
    57961 tgtcagcata atgatgcggt ctttgagaag acgtgagtaa atatcgtaag aacgttctcc
    58021 acggcttgtt tgttcaataa ctacaggaat cattcatttc tccttttgag ttttaatttt
    58081 gttggtcaaa tgactgaaga taagactatt ataatatctt ggtcaaaaaa ggtcaaattt
    58141 ttgctctgct ttcattagac agaaacaaaa acccaacctc ctttcgtgac tggaaatact
    58201 tttccaagtc attcttcttt tcgatcttat tttgtaccga acaagcggtc tccagcatct
    58261 ccaagacctg gaacgatata accgtgttcg ttcaaacgtt catccaaggc tgctgtaaag
    58321 atttctacat ctggatgagc ttcttgaagg acttttacac cctctggagc agatacaagg
    58381 cagacaaatt tgatatttga tgcgccacgt tttttaagag aatcaacagc caagattgct
    58441 gagccacctg ttgccaacat tggatctact acaaaaattt gacgttggtc aatgtcctca
    58501 ggcaatttca ccaagtattc aactggttga agtgtttctt catcacggta cataccgatg
    58561 tggccaactt tagcagctgg aaccaagctc aagagaccat caaccatccc gatacctgca
    58621 cgcaagattg ggacgatggc caatttctta cctgccaatt gtttttgaac tgtttttgta
    58681 attggtgttt cgatttccac atcttctagt ggaagatcac gaagtacttc ataccccatc
    58741 aacattgcaa tctcatctac tagctcacga aaagcttttg tagaagtatc tgtacgacgc
    58801 aagattgaca atttgtgttg aatcagtggg tgattaataa cttcaatttt tcccattttt
    58861 ggaattcctt ctttcaattt attcttctta ttataccaaa aaacggttta aaaatctttc
    58921 taaaccattt atttttgata atttttacat tagatcagcc tctttaagag ctgtctgtac
    58981 tgtctcaagt ggtaaatggg tcaattctgt ccctttttct tgataaaggt attgggcgta
    59041 gtcgtccatt cggtactggt tgatataaac cacgcgcttg cagccgacct gaagcaattg
    59101 ttttgtacag ttgagacaag gaaaatgggt tacataggct gtaaagcctt tgggaacacc
    59161 acgctcagca ccttgaagga tagcattgac ctcagcgtga agggtgcgaa cacagtggcc
    59221 ttcaatgacc aaacattcgt gatcaataca atgctcagtc cctgacaccg aaccattgta
    59281 accagtggaa ataaccttat tatcttttac cagaatcgcg cccactttag cacgtttaca
    59341 agtggaacga ttcgcaatta gtagggcttg ggctgcaaaa tactcatccc aggccagtct
    59401 tttttcagtc atctcttttc tcctttttct ctatttttta aaaaatggta aacctaaatc
    59461 tgcaatcttt tcagctggta ccttcatgcc atccttgatc cattttagaa ggacagagac
    59521 gatggctgag ctccagaagg aatgaagata agagctgaca ccttttgatt tcccatggta
    59581 tttttctaga aattcctgca tggcttggac aaagattttt tccagatggt aatccaaggc
    59641 caattgaatt actctagctt cctttctggt ctcccggaaa aggtgaaccc aaaccaaata
    59701 aaggtctgtc tttaaatcgt aatgatgcag ctgttccata atattgtgga cagttcgttt
    59761 aaagacgctc tctaaaattt cctctttgga gtcataattg cgataaaagg ccgcacgcga
    59821 aacacctgca cgtttgacca attcagaaat actaatcttg gtcagctcct ttttttccaa
    59881 gagttgcaag agggctgttt caatggcttc tctggttaat aaattggatt cttggtttga
    59941 ttttctgaga ttttcaagag acttttcaga gattctacgt tcagacataa cattttcttt
    60001 ctacttgtca caacagacgg atgatgcttt tgtttcaaga gttttcatga tataattgta
    60061 aaaaaagaca gaacctttgt caatgtataa ctgacaaaga tggagaattt ctatgacttg
    60121 gaagattatt gctgactctg gttgtgatta tcgtcaactg ccaacaccag ctattaacac
    60181 aacctttgta agtgtcccct taaccattca agtagctgat caggtctttg ttgatgacgc
    60241 cagtctcgat attgaccaaa tgatggaaac catgtatgca actgcagaag cttcaaaatc
    60301 agcttgtcca agcccagatg actatttgcg agcatttgaa ggtgccaaaa acattttcct
    60361 agtaaccatc acaggtaccc tttctggcag tcacaatagt gctcaactag caaagaatat
    60421 ttatctggaa gaccatcctg acactaagat tcatgtgatt gatagtttat ctgctggtgg
    60481 tgaagttgac ctactcgtag aaaaattgaa tgacttgatt gaccagggct tgtcttttga
    60541 agaagtggtt gaagctatca ccgcctatca agaaaaaact aagttgctct ttgtcctagc
    60601 caaagtcgat aacttggtga agaacggccg tttgagcaag cttatcggta cggtcgttgg
    60661 ccttctcaac attcgtatgg tcggaaaagc tagtgaaact gggactctcg aattgctaca
    60721 aaaagcaagg ggatcaaaga aatcagttca agctgcctat gatgagttag taaaagctgg
    60781 atatgctggt ggccgtattg tcatggccca acgcaataac gaaaaatgtt gtcaacagct
    60841 ctcagagcga atccgtgaaa ccttcccaca agcggatatt aaaattctac caacctctgg
    60901 tctctgcagt ttctatgcag aagagggcgg tttgctgatg ggctatgaaa ttgattaatt
    60961 gcattcttga caagaggtga ccatcatctc ttgttttttt gtggtacaat agagctatga
    61021 aacattttga tactattgtc atcggtgggg gacctgctgg tatgatggct actatttcca
    61081 gtagctttta tggacagaaa accctcctca tcgaaaaaaa tcggaaactt ggaaaaaaat
    61141 tagctgggac tggtggggga cgttgcaatg tgaccaacaa tggtagctta gacaacctgc
    61201 tagctggaat tcctggaaac ggacgctttc tttacagtgt tttctcccaa ttcgataatc
    61261 atgacatcat caactttttt acagaaaatg gtgttaaact taaggtcgaa gaccacggac
    61321 gcgtctttcc agccagtgac aagtctcgga ctattatcga agctttggaa aagaaaatca
    61381 ccgaactagg tggtcaagtt gctactcaaa tagaaatcgt ttctgttaaa aaagtagatg
    61441 atcagtttgt ccttaagtca gcggatcaaa ccttcacttg tgagaaactc attgtcacaa
    61501 caggtggtaa gtcttatcct tcgactggtt cgactggttt tggtcacgag attgctcgcc
    61561 attttaagca taccatcacc gatcttgagg ctgctgaaag tcctttatta acagattttc
    61621 cacataaagc cttacaaggg atttctttgg acgatgtgac cctaagttat ggtaagcatg
    61681 tcatcactca tgatttactc tttacccact ttggtttgtc aggtcctgct gccctacgca
    61741 tgtctagctt tgtcaaaggt ggggaggttc tctcactcga tgttttgcct caactttctg
    61801 agaaggactt ggttacattt ctagaagaaa atcgggaaaa atccttgaaa aacgctttaa
    61861 aaaccttgtt accagaacgc ttggccgaat tttttgtaca aggatatcct gaaaaagtca
    61921 aacagctgac tgaaaaggaa cgagaacagc ttgtccagtc cattaaagaa cttaaaattc
    61981 ctgtaactgg aaaaatgtcc cttgcaaagt cctttgttac caagggtgga gtcagtctca
    62041 aggaaatcaa tcctaaaacc cttgaaagta agctggtacc tggcctccac tttgcaggcg
    62101 aagttatgga tatcaatgcc cacacgggtg gctttaacat cacttctgcc ctctgtaccg
    62161 gctgggtggc gggaagtctg cattatgatt aaagattaaa ggttgtgaag aatgaacaga
    62221 agagaggcag tcgaatttgt taacatgtgt atgattaaaa acggagataa ggtcctggtc
    62281 caagaccgag ttagtcccga ctggcctggc attacttttc ctggtggtca tgttgaacgt
    62341 ggcgaatcct ttgtcgatgc tgtcattcgt gaagtgaaag aagaaactgg tctgatcatt
    62401 tccaaacccc aactctgtgg tatcaaaaac tggtatgacg acaaggatta tcgttatgtc
    62461 gtcctttttt acaagacaga acactttact ggtgaactcc agtcttcaga cgaagggaaa
    62521 gtttggtggg aggactttga aaatctttct catctaaaac ttgcaaccga tgatatgtct
    62581 gatatgcttc gtgtgtttct agaagaagat ctcagtgaat tcttttacta caaaaacggt
    62641 gacgactggc tttatgattt gaagtaaaaa ataggctagg aaattcctag cctatttttt
    62701 ctgcatttgt ctgaacgtaa gctgcaatgg catctgacgt gtactgggct gttccagaac
    62761 caaacttgtc aatgttttcc ttaaactctg ggttgtagac gtaatcttta ccgatatgac
    62821 cgaatacctc aatagagcag tcaaatccat aagtgcgaat ggcttgcaag agcttggctg
    62881 cttgctcttg gttttcggtt gctgttgcag gtaaaccaac ttgaagattt tgtgccaaag
    62941 tttgaaagac ttggttaaag gcggccgtag cctcgtcttc gtgacctttt tggcgttcga
    63001 gcgcttgtcc catgacttct tgaccatatt tctctaccgc ttcttggtgg tatttttgat
    63061 tgtcttgata gctaaatccc gtgaattttt cctcaatggt catttttctt tctccttttt
    63121 gttcttgaat agttttttgc aaggtggaaa tcaaggtatc cagatgttgc ctttcgcgag
    63181 ttagatagtc caactgccta gtcaaatggg gcaataaatc tgtcctttct tcctttaaca
    63241 gctctgctat tttctctaaa gaaaagccta gatatttgta gtaaagaatg acctgaaggc
    63301 gttccaaatc ctcttgactg taggttcgat agccgttttc cgactttaag gggaccaaga
    63361 gtcctatctt gtcatagtga tgcagggtct tgacagagac acctgaaagc tgcgcagttt
    63421 cttttatatg gtacatgatt tcctccttac aatgatagta taacccctcc ccttaggtca
    63481 gagtcaagcg tttttgagaa aattttttaa cttttttgag aaaggtgtga aaacttgaaa
    63541 atgattttct tgacagacct tagaaaacat gataggatag tcaagtctat caatcaaaca
    63601 gaaggctatt tgacaactca agtagctttt tcttattttg aaaaaggaga tcagagttta
    63661 actatgtcag aaaaatcaca atgggggtcg aaacttggtt ttattctagc atctgctggc
    63721 tcggtcatcg ggcttggttc cgtttggaag tttccctaca tgactgctgc taatggcggt
    63781 ggaggctttt tactaatctt tctcatttcc actattttaa tcggtttccc tctcctgctg
    63841 gctgagtttg cccttggccg tagtgctggt gtttccgcta tcaaaacctt tggaaaactg
    63901 ggcaagaata acaagtacaa ctttatcggt tggattggcg cctttgccct ctttatcctc
    63961 ttatcttttt acagtgttat cggaggatgg attctagtct atctaggtat tgagtttggg
    64021 aaattgttcc aacttggtgg aacgggtgat tatgctcagt tatttacttc aatcatttca
    64081 aatccagcca ttgccctagt agctcaagca gcctttatct tattaaatat ctttattgta
    64141 tcacgtgggg ttcaaaaagg gattgaaaga gcttcgaaag tcatgatgcc cctgctcttt
    64201 atcatctttg ttgttatcat cggtcgctct ctcagtttgc caaatgccat ggaaggggtt
    64261 ctttacttcc tcaaaccaga cttttcaaaa ctgactagcg ctggtcccct ctatgctctg
    64321 ggacaatctt tctttgccct ctcactaggg gttacagtca tgctgaccta tgcttcttac
    64381 ttggacaaga aaaccaatct agtccagtca ggaatctcca tcgtagccat gaatatctcg
    64441 atatccatca tggcaggtct agccattttc caagctcggt cccccttcag actggatatt
    64501 gaagggggac cgagcttgct ctttatcgtc ttgcctcaac tctttgacaa gatgcctttt
    64561 ggaaccattt tctacgtcct tttcctcttt gcgactgtca cttcttctgt cgtgatgctg
    64621 gagatcaatg tgggcaatat caccaaccag gataacagca aacgtgccaa atggagtgtt
    64681 attttaggaa ttttgacctt tgtctttggc attccttcag ccctatctta cggtgtcatg
    64741 gcggatgttc acatttttgg taagatcttc tttgacgcta tggacttctt ggcttccaat
    64801 ctcctcatgc catttggagc tctctacctt tcacttttta caggctatat ctttaaaaag
    64861 gctcttgcaa tggaggaact ccatctcgat gaaagagcat ggaaacaagg actgttccaa
    64921 gtctggctct tccttcttcg tttcttcgtt tcgtcattcc aatcatcatc attgtggtct
    64981 tcattgccca atttatgtaa tcaaaaagga cttgagtagt gaactcaggc cctttctttt
    65041 tatggatggc taacaatcaa ttccaaacct tgcccttcca gagtccaagc ttcaacatca
    65101 cttggtagga taaagtgtct ccctttttga attggataat ttttcccgtc aacagttagc
    65161 tgaccttgac cagctaagac actcaataag ctgtagtcag ctgtcttttc aaagtcaact
    65221 tttccagtaa tttcccactt gtaaactgcg aagaaatcat tagatacaag gagagtggaa
    65281 cgcaaatcat ctgctttaac agttacagga cggctatttg ctggctcacc aatgttcaag
    65341 acatcgatgg atttttcaag atgaagttca cgcaagttgc ctttgtcatc cttgcggtca
    65401 aagtcataga cgcgataggt ggtatcgcta gactgctggg tttcaaggat taagataccc
    65461 gccccgatag cgtgcatagt cccgcttggt acatagaaga aatctccagc cttaacaggg
    65521 actttggtca acaagtcatc ccagttcttg tcctcgattt gctggcggag ttcttctttt
    65581 gacttggcat tgtgaccgta gataatctct gaaccttcat ccgctgcgat aatgtaccag
    65641 cattctgttt ttccgagttc gccttcatgc tcgagtccat aagcatcgtc tgggtgaact
    65701 tggacactga gccagtcgtt ggcatcgagg atcttggtca aaagtggaaa tacaggttct
    65761 ggacgattgc caaataattc acggtgttcc gcatacaaag tagcaagatc tgttccctcg
    65821 taacgaccat tggcaacttt agagactcca tttggatggg ctgagatggc ccaatattct
    65881 ccgatttttt cacttgggat gtcgtagcca aactcatcac gtagcttggc tccaccccag
    65941 attttttctt gcataactga ttgtaaaaat aatggttctg acatgtcgat ctcctgtctg
    66001 atttttctcc cctcattata gcaaaaaaag agttcgaatt gaactctttt ttacatctta
    66061 taaagcaggg agaagatttt ataaaaatag taaacaaatg tgctctactc gatgcttaca
    66121 ccattgctat aaatgacatg taccaataga aggacttctt cttgctacgt ttgagagtcc
    66181 catttcctac attatctcga tctacataga taaagccata gcgcttattc atttcccctg
    66241 tgccagctga aaccgaatcg atacagcccc atgtcgtata accaagcaag tcaaccccgt
    66301 ctttgtaaat ggcatctcgc atggccttga tgtgggcctc taagtaagta atccgatagt
    66361 catctgctac ataaccattc tcatccggtg tatccatagc accgagtcca ttttctacga
    66421 taatactata ctaaaatcaa aaagcattat ataatagtga tatgaaatca actaaagaag
    66481 aaatccaaac catcaaaaca ctttttaaag actctcgtac agctaaatat cataaacgcc
    66541 ttcaaatcgt tctatagtaa aacgaaacaa gaacagggca aatcgatcag gacagtcaaa
    66601 tcgatttcta acaatgtttt agaagtagag gtgtactatt ctagtttcaa tttattatat
    66661 ttcgtctgat gggcaaatct tataaagaga ttatagaact tttatagtag tttgaaataa
    66721 gatgtgaaca actctatcag gaaagtcaaa ctaatttata gaaatatttt agcagctaag
    66781 gtgtactgtt atagattcaa tacactatag actgtaatca aacaa
//
LOCUS       DBERMM010000008        55729 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.008, whole genome shotgun sequence.
ACCESSION   DBERMM010000008 DBERMM010000000
VERSION     DBERMM010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 55729)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 55729)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..55729
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.008"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(137..826)
                     /gene="rplA"
                     /locus_tag="ACL8AS_000666"
     CDS             complement(137..826)
                     /gene="rplA"
                     /locus_tag="ACL8AS_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HGS1228576.1"
                     /translation="MAKKSKQLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEV
                     AYNLNIDVKKADQQIRGAMVLPNGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVA
                     KINDGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGK
                     ITYRADRAGNVQAIIGKVSFEAEKLVENFKAFNETIQKAKPATAKGTYVTNLTITTTQ
                     GVGIKVDVNSL"
     gene            complement(1034..1459)
                     /gene="rplK"
                     /locus_tag="ACL8AS_000667"
     CDS             complement(1034..1459)
                     /gene="rplK"
                     /locus_tag="ACL8AS_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004226069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HGS1228577.1"
                     /translation="MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNA
                     RTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTR
                     AQVQEIAETKMPDLNAANVESAMRMIEGTARSMGFTVVD"
     gene            complement(1768..2484)
                     /gene="ldcB"
                     /locus_tag="ACL8AS_000668"
     CDS             complement(1768..2484)
                     /gene="ldcB"
                     /locus_tag="ACL8AS_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase LdcB/DacB"
                     /protein_id="HGS1228578.1"
                     /translation="MKKRYIVLSGLLAVTLAACSQEKAKNEDGTAKTEQTAKADGTVG
                     SKSQGAAQKKAEVVNKGDYYSIQGKYDEIIVANKHYPLSKDYNPGENPTAKAELVKLI
                     KAMQEAGFPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYSEHQTGLAFD
                     VIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEI
                     AASGLSLEEYYGFEGGDYVD"
     gene            complement(2510..2971)
                     /locus_tag="ACL8AS_000669"
     CDS             complement(2510..2971)
                     /locus_tag="ACL8AS_000669"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HGS1228579.1"
                     /translation="MCLICQRIEWIKAGENPYFVKELETGYVVIGDHQYFKGYTLFLA
                     KEHVTELHHMETSVKLRFLEEMSLVQEAVAKTFKAEKMNIELLGNGDAHAHWHLFPRR
                     SGDMRGHGLNGRGPVWWVPWEEMAAEDCQVKSHELEQMIKALSDELEKYTV"
     gene            complement(2973..4010)
                     /locus_tag="ACL8AS_000670"
     CDS             complement(2973..4010)
                     /locus_tag="ACL8AS_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HGS1228580.1"
                     /translation="MNQTVEYIKELTAIASPTGFTREISNYLVKTLEGFGYQPVRTAK
                     GGVNVTIKGQNDEQHRYVTAHVDTLGAIVRAVKPDGRLKLDRIGGFPWNMIEGENCTV
                     HVASTGQKVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDVKVSNEKETRALGIEVG
                     DFISFDPRTVVTETGFIKSRHLDDKVSAAILLNLLRVYKEEGIELPVTTHFAFSVFEE
                     VGHGANSNIPSQVVEYLAVDMGAMGDDQQTDEYTVSICVKDASGPYHYDFRQHLVVLA
                     KEQDIPFKLDIYPFYGSDASAAMSAGAEVKHALLGAGIESSHSYERTHIDSVMATERM
                     VDAYLKSALVD"
     gene            complement(4108..5433)
                     /gene="brnQ"
                     /locus_tag="ACL8AS_000671"
     CDS             complement(4108..5433)
                     /gene="brnQ"
                     /locus_tag="ACL8AS_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HGS1228581.1"
                     /translation="MAKKGTLTGLLLFGIFFGAGNLIFPPSLGALSGEHFLPAIAGFV
                     FSGVGIAVLTLIIGTLNPKGYIYEISTKIAPWFATLYLSVLYLSIGPFFATPRTATTA
                     YEVGISPLLSDANKGLGLIVFTVLYFAAAYLISLNPSKILDRIGRILTPVFAILIVIL
                     VVLGAIKYGGTSPQAASAAYQASAFGTGFLEGYNTLDALASVAFSVIAVQTLKQLGFS
                     SKKEYISTIWVVGIVVALAFSALYIGLGFLGNHFPVPAEAMKGGTPGVYILSQATQEI
                     FGSTAQLFLAAMVTVTCFTTTVGLIVSTAEFFNERFPQISYKVYATAFTLIGFAIANL
                     GLDAIIKYSIPVLVILYPITIAIVMIVIVNKFVALSKPGMQLTIAVVTVIAIASVLGS
                     SFKVEFLANLVSVLPFAKASLPWLVPAIVGILLSLVLPNKQESDVFEME"
     gene            complement(5604..5891)
                     /locus_tag="ACL8AS_000672"
                     /pseudo
     CDS             complement(5604..5891)
                     /locus_tag="ACL8AS_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658232.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
     gene            complement(6051..6629)
                     /locus_tag="ACL8AS_000673"
     CDS             complement(6051..6629)
                     /locus_tag="ACL8AS_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HGS1228582.1"
                     /translation="MSQIERIKQAIMADSQNASYTERGIEPLFAAPKTARINIIGQAP
                     GLKTQEAGLYWKDKSGDRLRDWLGVDEDTFYNSGYFAVLPMDFYFPGHGKSGDLPPRT
                     GFAEKWHPQLLQELPDIQLTLLIGQYAQAYYLQEKISGKVTERVKHYKDYLPAYFPLV
                     HPSPRNQIWMAKNPWFEAEVVPDLKKRIKTIL"
     gene            complement(6683..8083)
                     /gene="pepV"
                     /locus_tag="ACL8AS_000674"
     CDS             complement(6683..8083)
                     /gene="pepV"
                     /locus_tag="ACL8AS_000674"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004151 - dihydroorotase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HGS1228583.1"
                     /translation="MIAIDFTAEVEKRKEDLLADLFSLLEINSERDDSKADAQHPFGP
                     GPVKALEKFLEIADRDGYPTKNVDNYAGHFEFGDGEEVLGIFAHMDVVPAGSGWDTDP
                     YTPTIKDGRLYARGASDDKGPTTACYYGLKIIKELGLPTSKKVRFIVGTDEESGWADM
                     DYYFEHVGLAKPDFGFSPDAEFPIINGEKGNITEYLHFAGENTGAARLHSFTGGLREN
                     MVPESATAVVSGDLADLQAKLDAFVAEHKLRGELQEEAGKYKVTIIGKSAHGAMPASG
                     VNGATYLALFLSQFGFAGPAKDYLDIAGKILLNDHEGENLKIAHVDEKMGALSMNAGV
                     FRFDETSADNTIALNIRYPKGTSPEQIKSILENLPVASVSLSEHGHTPHYVPMEDPLV
                     QTLLNVYEKQTGLKGHEQVIGGGTFGRLLERGVAYGAMFPDSIDTMHQANEFIALDDL
                     FRAAAIYAEAIYELIK"
     gene            complement(8096..8701)
                     /locus_tag="ACL8AS_000675"
     CDS             complement(8096..8701)
                     /locus_tag="ACL8AS_000675"
                     /EC_number="1.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002924506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0016657 - obsolete oxidoreductase
                     activity, acting on NAD(P)H, nitrogenous group as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HGS1228584.1"
                     /translation="MKFLELNKKRHATKHFTDKPVDPKDVRTAIEIATLAPSVHNSQP
                     WKFVVVREKNAELAKLAYGSNFEQVSSAPVTIALFTDTDLAKRARKIARVGGANNFSE
                     EQLQYFMKNLPAEFARYNEQQVSDYLALNAGLVAMNLVLALTDQGIGSNIILGFDKSK
                     VNEVLEIEDRFRPELLITVGYTDDKLEPSYRLPVDEIIEKR"
     gene            8872..9672
                     /locus_tag="ACL8AS_000676"
     CDS             8872..9672
                     /locus_tag="ACL8AS_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1228585.1"
                     /translation="MKKFSLLLAILPFLVACGNQATPKESSSQKTIVLATAGDVPPFD
                     YEDKGNLTGFDIEVLKAVDEKLSDYEIQFQRTAWESIFPGLDSGHYQAAANNLSYTKE
                     RAEKYLYSLPISNNPLVLVSNKKNPLTSLDQIAGKTTQEDTGTSNAQFINHWNQKHTD
                     NPATIDFSGEDIGKRILDLANGEFDFLVFDKVSVQKIIKDRGLDLSVVDLPSADSPSN
                     YIIFSSDQKEFKEKFDKALKELYQDGTLEKLSNTYLGGSYLPDQSQLQ"
     gene            complement(9854..10687)
                     /locus_tag="ACL8AS_000677"
     CDS             complement(9854..10687)
                     /locus_tag="ACL8AS_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HGS1228586.1"
                     /translation="MNHKIAILSDVHGNATALEAVIADAKTQGASEYWLMGDIFLPGP
                     GANDLVALLKELPITASVRGNWDDCVLEALDGQYGLEDPQEVQLLRMTQYLMERMDPA
                     TIVWLRSLPLLEKKEIDGLRFSISHNLPDKNYGGDLLVENDTEKFDQLLDAETDVAVY
                     GHVHKQLLRYGSQGQQIINPGSIGMPYFNWEALKNHRAQYAVIEVEDGELLNIQFRKV
                     AYDYEAELELAKSKGLPFIEMYEELRRDDNYQGHNLELLASLIEKHGYVEDVKNFFDF
                     L"
     gene            complement(10677..12524)
                     /gene="uvrC"
                     /locus_tag="ACL8AS_000678"
     CDS             complement(10677..12524)
                     /gene="uvrC"
                     /locus_tag="ACL8AS_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009380 - excinuclease repair complex
                     [Evidence IEA];
                     GO_function: GO:0009381 - excinuclease ABC activity
                     [Evidence IEA];
                     GO_process: GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HGS1228587.1"
                     /translation="MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSY
                     FRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFI
                     KITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
                     YYHIGQCMAHTICKKDEAYFKSMAQEVSDFLKGQDNKIIDELKGKMAAAAQTMEFERA
                     AEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNL
                     FPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDSKILKPQRGEKK
                     QLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGT
                     SPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLI
                     VIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEF
                     FLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMRHFKSLTKIKEA
                     SVDEIVEVGVPRAVAEAVQTKLNPQETEILLQVAEERVDYQTEGNHNKP"
     gene            complement(12564..13265)
                     /locus_tag="ACL8AS_000679"
     CDS             complement(12564..13265)
                     /locus_tag="ACL8AS_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M57 family metalloprotease"
                     /protein_id="HGS1228588.1"
                     /translation="MRWLFRLIGAFFSFVWRLFWRLVWIVVLLCVLAFGLLWYLNGDF
                     QGALKQAERSVKIGQQSIDQWEKTGQLPKLSQTDSHQHSEGRWAQASARIYLDPQMDS
                     RFQEAYLEAIQNWNQTGAFNFELVTESSKADITATEMNDGGTPVAGEAESQTNLLTGQ
                     FLSVTVRLNHYYLSNPYYGYSYERLVHTAEHELGHAIGLDHTDEKSVMQPAGSFYGIQ
                     EEDVANLRKIYETSE"
     gene            complement(13344..14576)
                     /gene="murN"
                     /locus_tag="ACL8AS_000680"
     CDS             complement(13344..14576)
                     /gene="murN"
                     /locus_tag="ACL8AS_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurN"
                     /protein_id="HGS1228589.1"
                     /translation="MALTTLTKEEFQTYSDQVSSRSFMQSVQMGDLLEKRGARIVYLA
                     LKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELL
                     VKPYETYQTFDSQGNSIDAEKKSIIQGLTDLGYQFDGLTTGYPGGEPDWLYYKDLTEL
                     TEKSLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEY
                     YEHFYDTFGEQAEFLIASLNFSDYMSKLQGEQSKLEENLDKLRLDLSKNPHSEKKQNQ
                     LREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKF
                     YAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYH
                     PSPLKYKAIQLLKKIVGR"
     gene            complement(14581..15801)
                     /gene="murM"
                     /locus_tag="ACL8AS_000681"
     CDS             complement(14581..15801)
                     /gene="murM"
                     /locus_tag="ACL8AS_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurM"
                     /protein_id="HGS1228590.1"
                     /translation="MYRYQIGIPTLEYDQFVKEHELANVLQSSAWEEVKSNWQHEKFG
                     VYREEKLLATASILIRTLPLGYKMFYIPRGPILDYGDKELLNFVIQSIKSYARSKRAV
                     FVTFDPSICLSQSLINQEKTEFPENLAIIDSLQQMGVRWSGKTEEMGDTIQPRIQAKI
                     YKENFEEDKLSKSTKQAIRTARNKGLEIQYGGLELLDSFSELMKKTEKRKEIHLRNEA
                     YYKKLLDNFKDKAYITLATLDVSKRSQELEEQLAKNRALEETFTESTRISKVEAQKKE
                     KERLLEELTFLQEYIDVGQARVPLAATLSLEFGTTSVNIYAGMDDDFKRYNAPILTWY
                     ETARYAFERGMVWQNLGGVENSLNGGLYHFKEKFNPTIEEYLGEFTMPTHPLYPLLRL
                     ALDFRKTLRKKHRK"
     gene            complement(15913..16692)
                     /locus_tag="ACL8AS_000682"
     CDS             complement(15913..16692)
                     /locus_tag="ACL8AS_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HGS1228591.1"
                     /translation="MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECEDIPVLYLLH
                     GMSGNHNSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQVLK
                     RFFPNMTSKREKTFIAGLSMGGYGCFKLALTTNRFSHAASFSGALSFQNFSPESQNLG
                     SPAYWRGVFGEIRDWTTSPYSLESLAKKSDKKTKLWAWCGEQDFLYEANNLAVKNLKK
                     LGFDVTYSHSAGTHEWYYWEKQLEVFLTTLPIDFKLEERLT"
     gene            complement(16761..18422)
                     /locus_tag="ACL8AS_000683"
     CDS             complement(16761..18422)
                     /locus_tag="ACL8AS_000683"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004540 - RNA nuclease activity [Evidence
                     IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HGS1228592.1"
                     /translation="MSNISLTTLGGVRENGKNMYIAEIGESIFVLNVGLKYPENEQLG
                     VDVVIPNMDYLFENSDRIAGVFLTHGHADAIGALPYLLAEAKVPVFGSELTIELAKLF
                     VKGNDAVKKFNDFHVIDENTEIDFGGTVVSFFPTTYSVPESLGIVLKTSEGSIVYTGD
                     FKFDQTASESYATDFARLAEIGRDGVLALLSDSANADSNIQVASESEVRDEITQTIAD
                     WEGRIIVAAVSSNLSRIQQIFDAADKTGRRIVLTGFDIENIVRTAIRLKKLSLANEIL
                     LIKPKDMSRFEDHELIILETGRMGEPINGLRKMSIGRHRYVEIKDGDLVYIATAPSIA
                     KEAFVARVENMIYQAGGVVKLITQSLHVSGHGNVRDLQLMINLLQPKYLFPVQGEYRE
                     LDAHAKAAMAVGMLPERIFIPKKGTTMAYENGDFVPAGSVSAGDILIDGNAIGDVGNV
                     VLRDRKVLSEDGIFIVAITVNRREKKIVARARVHTRGFVYLKKSRDILRESSELINQT
                     VEDYLQGDDFDWADLKGKVRDNLTKYLFDQTKRRPAILPVVMEAK"
     gene            complement(18597..20819)
                     /gene="recJ"
                     /locus_tag="ACL8AS_000684"
     CDS             complement(18597..20819)
                     /gene="recJ"
                     /locus_tag="ACL8AS_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008409 - 5'-3' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HGS1228593.1"
                     /translation="MITPTYEWQFALQVEDADFTKIAKKAGLGPEVARLLFERGIQNQ
                     ESLKKFLEPSLEDLHDAYLLHDMDKAVERIRQAIEEGENILVYGDYDADGMTSASIVK
                     ESLEQLGAECRVYLPNRFTDGYGPNASVYKYFIEQEGISLIVTVDNGVAGHEAIALAQ
                     SMGVDVIVTDHHSMPETLPDAYAIVHPEHPDADYPFKYLAGCGVAFKLACALLEEVQV
                     ELLDLVAIGTIADMVSLTDENRILVQYGLEMLGHTQRIGLQEMLDMAGIAANEVTEET
                     VGFQIAPRLNALGRLDDPNPAIDLLTGFDDEEAHEIALMIHQKNEERKEIVQSIYEEA
                     KTMVDPEKKVQVLAKEGWNPGVLGIVAGRLLEELGQTVIVLNIEDGRAKGSARSVEAV
                     DIFEALDPHRDLFIAFGGHAGAAGMTLEVEQLSDLSQVLEDYVREKGADAGGKNKLNL
                     DEELDLEALSLETVKSFERLAPFGMDNQKPIFYIKNFQVESARTMGAGNAHLKLKISK
                     GEASFEVVAFGQGRWATEFSQTKNLELAVKLSVNQWNGQTALQLMMVDARVEGVQLFN
                     IRGKNAVLPEGVPVLDFPGELPNLAASEAVVVKNIPEDITQLKTIFQEQHFSAVYFKN
                     DIDKTYYLTGYGTRDQFAKLYKTIYQFPEFDIRYKLKDLAAYLNIQQILLVKMIQVFE
                     ELGFVTIKDGVMTVNKEAPKREIGESQIYQNLKQTVKDQEMMALGTVQEIYDFLMEKE
                     "
     gene            21096..21854
                     /locus_tag="ACL8AS_000685"
     CDS             21096..21854
                     /locus_tag="ACL8AS_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HGS1228594.1"
                     /translation="MALVEFKNVEKYYGDYHALRDINLRFEKGQVVVLLGPSGSGKST
                     LIRTINGLEAVDKGSLLVNGHQVAGASQKDLVPLRKEVGMVFQHFNLYPHKTVLENVT
                     LAPIKVLGIDKKEAEKTAQKYLEFVNMWDKKDSYPAMLSGGQKQRIAIARGLAMHPEL
                     LLFDEPTSALDPETIGDVLAVMQKLAHDGMNMIIVTHEMGFAREVADRIIFMADGEVL
                     VDTTDVDNFFDNPSEPRAQQFLSKIINHESDKVK"
     gene            21865..22659
                     /locus_tag="ACL8AS_000686"
     CDS             21865..22659
                     /locus_tag="ACL8AS_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HGS1228595.1"
                     /translation="MKKKFFLSALLISLFGLAAAKPVQADTSIADIQKRGELVVGVKQ
                     DVPNFGYKDPKTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIA
                     TFTITDERKKLYNFTSPYYTDASGFLVNKSAKIKKIEDLNGKTIGVAQGSITQRLITE
                     LGKKKGLKFKFVELGSYPELITSLHAHRIDAFSVDRSILSGYTSKRTELLDDSFKPSD
                     YGIVTKKSNTELNDYLDNLVTKWSKDGSLQKLYDRYKLKPSSHTAD"
     gene            22672..23349
                     /locus_tag="ACL8AS_000687"
     CDS             22672..23349
                     /locus_tag="ACL8AS_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HGS1228596.1"
                     /translation="MTDLSSWTAYFQDFGQFFNGFLFTLALAIGSFILAMVLGIFFGA
                     MSTSKRPILRILAHIFVEFYQNTPLLVQFVIVFYGLPLISDHTIMIPIYWTAVLCMGL
                     YHGAYIAEVIRSGIQSIPSGQMEAALSQGFTYISAMRLIILPQTFRIILPPLTNQIVN
                     LIKNTSTVAIISGVDLMFVTKSWSALNGNYIPAFLGAALLYFALCFPVAQFGRKMEQA
                     NKKAYSL"
     gene            23359..24018
                     /locus_tag="ACL8AS_000688"
     CDS             23359..24018
                     /locus_tag="ACL8AS_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HGS1228597.1"
                     /translation="MESILEVLTPDNLVFIFKGFGLTLYISLIAIILSTIIGTVLAVM
                     RNGKNPVLRIISSIYIEFVRNVPNLLWIFTIFLVFKMKSTPAGITAFTLFTSAALAEI
                     IRGGLNAVDKGQYEAGMSQGFTSAQILYYIILPQAIRKMLPAIISQFVTVIKDTSLLY
                     SVIALQELFGASQILMGRYFEPEQVFSLYILIALIYFSFNLAISSLSHMLAKRWQQAA
                     E"
     gene            24313..25503
                     /locus_tag="ACL8AS_000689"
     CDS             24313..25503
                     /locus_tag="ACL8AS_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="HGS1228598.1"
                     /translation="MKSVKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFIL
                     ATRLPLLESWFHGLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGNLAIYI
                     FASIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRLLTFNLLSFLVGSY
                     ALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTREIQIHLSRPFNYQSGQFAFLK
                     IFQEGFESAPHPFSISGGHGQTLYFTVKNSGDHTKNIYDNLQAGSKVTLDRAYGHMII
                     EEGRENQVWIAGGIGITPFISYIREHPILDKQVHFYYSFRGDENAVYLDLLRNYAQKN
                     PNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEG
                     FKFK"
     gene            complement(25824..26705)
                     /locus_tag="ACL8AS_000690"
     CDS             complement(25824..26705)
                     /locus_tag="ACL8AS_000690"
                     /EC_number="4.1.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="HGS1228599.1"
                     /translation="MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAP
                     VLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTS
                     IMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
                     AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQI
                     QAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAI
                     QASVEERIDVFGSEGKA"
     gene            complement(26846..28174)
                     /gene="vncS"
                     /locus_tag="ACL8AS_000691"
     CDS             complement(26846..28174)
                     /gene="vncS"
                     /locus_tag="ACL8AS_000691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase VncS"
                     /protein_id="HGS1228600.1"
                     /translation="MKRTGLFAKIFIYTFSIFSVLVICLHLAIYFLFPSTYLSHRQET
                     IGQKATAIAQSLEGKDRQSIEQVLDLYSQTSDIKGTVKGEMTEDKLEVKDSLPLDTDR
                     QTTSLFIEEREVKTQDGGTMILQFLASMDLQKEAEQISLQFLPYTLLASFLISLLVAY
                     IYAWTIVAPILEIKRVTRRMMDLDSQVRLRVDSKDEIGNLKEQINSLYQHLLTVIADL
                     NEKNEAILQLEKMKVEFLRGASHELKTPLASLKILIENMRENIGRYKDRDQYLGVALG
                     IVDELNHHVLQILSLSSVQELRDDRETIDLLQMTKNLVKDYALLAKERELQIDNSLTH
                     QQAYLNPSVMKLILSNLISNAIKHSVPGGLVRIGEREGELFIENSCSSEEQEKLAQSF
                     SDNASRKVKGSGMGLFVVKSLLEHEKLAYRFEMEENRLTFFIDFPKVVQD"
     gene            complement(28171..28827)
                     /gene="vncR"
                     /locus_tag="ACL8AS_000692"
     CDS             complement(28171..28827)
                     /gene="vncR"
                     /locus_tag="ACL8AS_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor VncR"
                     /protein_id="HGS1228601.1"
                     /translation="MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYE
                     VALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPF
                     SLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
                     KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIQKLRKKLDLDCILTVRNVGYKLERK
                     "
     gene            complement(28876..28959)
                     /gene="pep27"
                     /locus_tag="ACL8AS_000693"
     CDS             complement(28876..28959)
                     /gene="pep27"
                     /locus_tag="ACL8AS_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_198523890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative autolysis signal peptide Pep27"
                     /protein_id="HGS1228602.1"
                     /translation="MRKEFHNVLSSGQLLTDKRPARDYNRK"
     gene            complement(29139..30518)
                     /gene="vex3"
                     /locus_tag="ACL8AS_000694"
     CDS             complement(29139..30518)
                     /gene="vex3"
                     /locus_tag="ACL8AS_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit Vex3"
                     /protein_id="HGS1228603.1"
                     /translation="MLHNAFAYVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKAS
                     QETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKITENKAIESYVKRINAIGDLT
                     GYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDK
                     DKILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTY
                     SQELYENTAITDIHTAAKLYGYTEDTAIYGDATFFVTADKNLDDVMKELNGISGINWK
                     SYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALLLSLWINARRKEVGIL
                     LSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASK
                     AAQASNLGGGAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQ
                     PKELLLDGE"
     gene            complement(30570..31217)
                     /gene="vex2"
                     /locus_tag="ACL8AS_000695"
     CDS             complement(30570..31217)
                     /gene="vex2"
                     /locus_tag="ACL8AS_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding subunit Vex2"
                     /protein_id="HGS1228604.1"
                     /translation="MTLLQLQDVTYRYKNTAEAVLYQINYNFEPGKFYSIIGESGAGK
                     STLLSLLAGLDSPVEGSILFQGEDIRKKGYSYHRMHHISLVFQNYNLIDYLSPLENIR
                     LVNKKASKNTLLELGLDESQIKRNVLQLSGGQQQRVAIARSLVSEAPVILADEPTGNL
                     DPKTAGDIVELLKSLAQKTGKCVIVVTHSKEVAQASDITLELKDKKLTETRNTSK"
     gene            complement(31230..32507)
                     /locus_tag="ACL8AS_000696"
     CDS             complement(31230..32507)
                     /locus_tag="ACL8AS_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228605.1"
                     /translation="MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKT
                     VESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGLENVSPELETVAKLKDKEAVT
                     GEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEE
                     LAKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFT
                     DYESSQTLLGNSEAQVSAARFYVENPKEMDGLMKQVENLALENQGYQVEKENKAFEQI
                     KDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGILLALGKGKSSIFLQF
                     CLEVVLVSLGALLPAFVAGNAITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAE
                     SYVFLVLLSCLSVALCFLFLFRKSPKEILSSIS"
     gene            complement(32863..33033)
                     /locus_tag="ACL8AS_000697"
                     /pseudo
     CDS             complement(32863..33033)
                     /locus_tag="ACL8AS_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron maturase-specific
                     domain-containing protein"
     gene            complement(33176..33775)
                     /locus_tag="ACL8AS_000698"
     CDS             complement(33176..33775)
                     /locus_tag="ACL8AS_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228606.1"
                     /translation="MQILCYFTITVVAKPNNSGEVHLDVSIEDNQGGSGHNFSSVSSS
                     SQTAKYEEIGYNNNLSLYTTIDKTSDATALLKLKLNNVDNQPATEVPSSGITVKLNTK
                     DNAGNWTSASNKKEITVKIVSAKPTYPDKILVKNPDTIKDTEKNAIIEKLKEANKNHP
                     AGAPTFAKGEGEHANDIVATYSDGTTYYVPLNDVTKYAR"
     gene            complement(33912..34796)
                     /locus_tag="ACL8AS_000699"
     CDS             complement(33912..34796)
                     /locus_tag="ACL8AS_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1228607.1"
                     /translation="MRAKELQDWFPEARISDQPVEKEGYLTLPLASQQWILLEEAGLS
                     EREKQLVALLTQQEQARSLNPWYSYLVEGKGQAPQVFKKIQLVYCHLSYFQQENLASW
                     LDMMRTLFPNCQTVLQVGAQDYVFVLQQDKYTSVRDILSDTIEAVEYDFGLRLSIMLG
                     QVWSQTGHQALSDLIKAERDLFKTWWRQGHQGVHTFSQLYLWSMGERLVDLKPIKECL
                     HQMILDQDQIQEIILSLWENSAVLTKTAQQLYLHRNSLQYKIDKWEELTGLQLKELTD
                     LTLCYQLILGSLSTIVGL"
     gene            complement(34800..35186)
                     /locus_tag="ACL8AS_000700"
     CDS             complement(34800..35186)
                     /locus_tag="ACL8AS_000700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HGS1228608.1"
                     /translation="MIDVNLINGIALAFEGDAVYSMYIRRHLILKGMTKPNKLHQEAT
                     KYVSAKAQARLIALMLEEQVLTEKEEEIYKRGRNTNSHTKAKNADVVTYRMSTGFEAV
                     MGYLHMTENLERLESLVSWCIQKVEG"
     gene            complement(35179..36522)
                     /gene="cysS"
                     /locus_tag="ACL8AS_000701"
     CDS             complement(35179..36522)
                     /gene="cysS"
                     /locus_tag="ACL8AS_000701"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002916477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004817 - cysteine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006423 - cysteinyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HGS1228609.1"
                     /translation="MIKIYDTMSRDLREFVPIEDGKIKMYVCGPTVYNYIHVGNARST
                     VAFDTIRRYFEYRGYKVAYISNFTDVDDKIINRAREEGITPQEVADKYIAAFREDVTA
                     LGVKPATRHPRVVEFMADIIRFVEDLIERGFAYESQGDVYFRVEKSHNYAKLANKTLE
                     DLDLGASGRTDEETARKENPVDFALWKSSKPGEISWDSPWGPGRPGWHIECSVMSTEI
                     LGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKAFANYWMHNGFVNIDNVKMSKSLGNF
                     ITVHDALKTLDGQVLRFFFATQHYRKPINFTEKAVRDAETNLKYLKNTYEQPFTGNVD
                     AQELQNFKDKFVAAMDEDFNAANGITVVFEMAKWINSGNYDASVKQALADMLEIFGIV
                     FVEEVLDAEIEDLIQKRQEARANRDFETADQIRDQLVTQGIKLLDTKDGVRWTRD"
     gene            complement(36604..37488)
                     /locus_tag="ACL8AS_000702"
     CDS             complement(36604..37488)
                     /locus_tag="ACL8AS_000702"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228610.1"
                     /translation="MIQARNKLSQEELSEAKKVINCCQNYDGTYRDPYLSNMLNFDPN
                     MPAFFLYYEKGELVGLLTVYADDQDVEVTILVHPGHRRQGIARALFTSFERETASFPI
                     RSVTFQTERIFLENHPDFASNWGLIEDEETETWLGKDRRPYPLANVSHLEILLADSSY
                     QDQISQLKFQAFSEEHESREVVDRYVAEALKDPESRLYILLKAGQVIGTCTVDLSTNT
                     NYLYGLAILEPERGKGYGSYLAKSLVNQLIEQNDKEFQIAVEDSNVGAKRLYEKIGFV
                     KQTQVVYLNEKGARDSEV"
     gene            complement(37500..38117)
                     /gene="cysE"
                     /locus_tag="ACL8AS_000703"
     CDS             complement(37500..38117)
                     /gene="cysE"
                     /locus_tag="ACL8AS_000703"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000539958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0009001 - serine O-acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HGS1228611.1"
                     /translation="MGWWRETIDIVKENDPAARTTLEVLLTYPGVKALAAHRLSHFLW
                     KYDFKLLARMHSQFWRFWTQIEIHPGAQIDSGVFIDHGSGLVIGETAIVEKGVLLYHG
                     VTLGGTGKDCGKRHPTVRKGALISAHAQVIGPVEIGENAKVGAAAVVVADVPSDVTVV
                     GIPAKIVRLHGKKDEPVIHEVEEKREYYVNKLEQAKDASHRSSGL"
     gene            complement(38133..40346)
                     /gene="pnp"
                     /locus_tag="ACL8AS_000704"
     CDS             complement(38133..40346)
                     /gene="pnp"
                     /locus_tag="ACL8AS_000704"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004654 - polyribonucleotide
                     nucleotidyltransferase activity [Evidence IEA];
                     GO_process: GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HGS1228612.1"
                     /translation="MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAV
                     MSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFA
                     EGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQII
                     INPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQE
                     EIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQVVKDQVT
                     AVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVV
                     DFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGE
                     TGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGT
                     LALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITAL
                     QMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRLELAPTAPKIDTIKIDVD
                     KIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKV
                     DEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKI
                     DEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHHKDHKPKKEFTETPKDSE"
     gene            complement(41031..41897)
                     /gene="metF"
                     /locus_tag="ACL8AS_000705"
     CDS             complement(41031..41897)
                     /gene="metF"
                     /locus_tag="ACL8AS_000705"
                     /EC_number="1.5.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000089969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="HGS1228613.1"
                     /translation="MSRQTPSLSFEVFPPNPAVGNGNIISALQDMQELAPHFISVTAS
                     NNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALR
                     GDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKV
                     DAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIH
                     LPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQ
                     ATHALFNHQSLG"
     gene            complement(41961..44210)
                     /gene="metE"
                     /locus_tag="ACL8AS_000706"
     CDS             complement(41961..44210)
                     /gene="metE"
                     /locus_tag="ACL8AS_000706"
                     /EC_number="2.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003871 -
                     5-methyltetrahydropteroyltriglutamate-homocysteine
                     S-methyltransferase activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="HGS1228614.1"
                     /translation="MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAK
                     HWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQG
                     EKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVG
                     PFTFLQLSDFEEGVKADDFVDSLVAAYQEVFAKLAELGATRIQLDEAALVKDLTAEEK
                     ALFLNLYNKLLADKKGLEVLLQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVK
                     GGFPADKTLYVGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEE
                     FEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAG
                     LTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKE
                     YDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGM
                     RGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKD
                     STLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVH
                     STVASDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVG
                     PGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVE
                     AAKAAREKL"
     gene            complement(44471..44737)
                     /locus_tag="ACL8AS_000707"
     CDS             complement(44471..44737)
                     /locus_tag="ACL8AS_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HGS1228615.1"
                     /translation="MEGCPSELFSKEEILESDMRVAIMSELIEARYEQGISQKKLEEV
                     SGISQPVIARMETGKTSPQLDTVLKVLASLGKTLAIVPLEQGKS"
     gene            complement(44862..45265)
                     /locus_tag="ACL8AS_000708"
                     /pseudo
     CDS             complement(44862..45265)
                     /locus_tag="ACL8AS_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
     gene            45421..46428
                     /locus_tag="ACL8AS_000709"
     CDS             45421..46428
                     /locus_tag="ACL8AS_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000597989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HGS1228616.1"
                     /translation="MIKTFLSALSVILFVIPIIAYSFFPSSNLNIWLSTRPILAQIYA
                     FPLATATMASILSFVFFSLSFYKKNKQIRFYSGILLLLSLILLLFGTDKTLSSAPNKT
                     KTLKLVTWNVANQIEAQHIERIFSHFDADMAIFPELATNIRGEQENQRIKLLFHQVGL
                     SMANYDIFTSPPTNSGIAPVTVIVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQNIPD
                     IIALHTAPPLPGLMEIWKQDLNIIHNQLASKYPKAIIAGDFNATMRHGALAKISSHRD
                     ALNALPPFERGTWNSQSPKLFNATIDHILLPKNHYYVRDLDIVSFQNSDHRCIFTEIT
                     F"
     gene            complement(46496..48901)
                     /gene="pheT"
                     /locus_tag="ACL8AS_000710"
     CDS             complement(46496..48901)
                     /gene="pheT"
                     /locus_tag="ACL8AS_000710"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HGS1228617.1"
                     /translation="MLVSYKWLKELVDIDVPSQELAEKMSTTGIEVEGVESPAAGLSK
                     IVVGEVLSCEDVPETHLHVCQINVGEEEERQIVCGAPNVRAGIKVMVALPGARIADNY
                     KIKKGKIRGLESLGMICSLGELGISDSVVPKEFADGIQILPEDAVPGEEVFSYLDLDD
                     EIIELSITPNRADALSMCGVAHEVAAIYDKAVNFKEFTLTETDQVAADALSVGIETDK
                     APYYAARILDNVTIAPSPQWLQNLLMNEGIRPINNVVDVTNYILLYFGQPMHAFDLDT
                     FEGTDIRVREARAGEKLVTLDGEERDLDVNDLVITVADKPVALAGVMGGQATEISEKS
                     SRVVLEAAVFNGKSIRKTSGRLNLRSESSSRFEKGINVATVNEALDAAASLIAELAGA
                     TVRKGIVSAGELDTSDVEVSSTLADVNRVLGTELSYADVEDVFRRLGFGLSGNADSFT
                     VRVPRRRWDITIEADLFEEIARIYGYDRLPTSLPKDDGTAGELTVTQKLRRQVRTIAE
                     GAGLTEIITYALTTPEKAVEFTAQPSNLTELMWPMTVDRSVLRQNMISGILDTVAYNV
                     ARKNKNLALYEIGKVFEQTGNPKEELPNEINSFAFALTGLVAEKDFQTAAVPVDFFYA
                     KGILEALFTRLGLQVTYTATSEIASLHPGRTAVISLGDQVLGFLGQVHPVTAKAYDIP
                     ETYVAELNLSAIEAALQPATPFVEITKFPAVSRDVALLLKAEVTHQEVVDAIQAAGVK
                     RLTDIKLFDVFSGEKLGLGMKSMAYSLTFQNPEDSLTDEEVARYMEKIQASLEEKVNA
                     EVR"
     gene            complement(48978..49475)
                     /locus_tag="ACL8AS_000711"
     CDS             complement(48978..49475)
                     /locus_tag="ACL8AS_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228618.1"
                     /translation="MIRKVEMADVEVLAKIAKQTFAYDNTEEQLQEYFEEAYSLKTLS
                     TELGNPDSETYFIMHEEEIAGFLKVNWGSAQTERELEDAFEIQRLYVLQKFQGFGLGK
                     QLFEFALELATKNSFSWAWLGVWEHNTKAQAFYNRYGFEKFSQHHFMVGQKVDTDWLL
                     RKKLR"
     gene            complement(49475..50521)
                     /gene="pheS"
                     /locus_tag="ACL8AS_000712"
     CDS             complement(49475..50521)
                     /gene="pheS"
                     /locus_tag="ACL8AS_000712"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HGS1228619.1"
                     /translation="MSTIEEQLKALREETLASLKQITAGNEKEMQDLRVSVLGKKGSL
                     TEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVASQLASESIDVTL
                     PGRPVATGHRHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERMNLPKDHPARDM
                     QDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQ
                     IEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSVEVDVSCFKCGG
                     EGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERVAMLRYGINDIR
                     GFYQGDVRFSEQFK"
     gene            complement(51113..52528)
                     /locus_tag="ACL8AS_000713"
     CDS             complement(51113..52528)
                     /locus_tag="ACL8AS_000713"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HGS1228620.1"
                     /translation="MTIFPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEA
                     TENPTEDNLKLLGIDFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGL
                     KYYDELFDELHAHGIEPLVTLSHYETPLYLARKYHGWIDRRMIHFYEKFARTVLERYK
                     DKVKYWLTFNEVNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREI
                     NSEFKVGCMVLAMPAYPMTPNPKDVWATHEYENLNYLFSDVHVRGYYPNYAKRYFKEH
                     DINIEFAAEDAELLKNYTVDFLSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESS
                     EWGWQIDPIGLRIILNRYYDRYQIPLFIVENGLGAKDQLIKDEFNNLTVQDDYRIQYM
                     KEHLLQVAEALQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGNGTFNRY
                     KKMSFTWYKGVIESNGESLFK"
     gene            complement(52541..54379)
                     /locus_tag="ACL8AS_000714"
     CDS             complement(52541..54379)
                     /locus_tag="ACL8AS_000714"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_function: GO:0015573 - beta-glucoside transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0015759 - beta-glucoside transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-glucoside-specific PTS transporter subunit
                     IIABC"
                     /protein_id="HGS1228621.1"
                     /translation="MSYKDTVQKILDVIGGEKNVNRVTHCVTRLRLELKDENLVNDDD
                     VKKIPGVIGIMKKNGQYQIILGNDVANYYKEFVKLGNFESDSVNQGYKGNILERIIEY
                     IAGSMTPIIPAMLGGGMLKVLVIILPMLGILQSDSQTIAFLTFFGDAPYYFLPLLLAY
                     SASQKLKVTSTLAMSVAGVLLHPNFVQMVQSGNPLSLFGAPVTPASYGSSVVPILIMV
                     WLMKYIEKIIAKLTPAITKSFLQPTLVLLVSSCIALVVVGPIGVIVGEGLSNLVGQMY
                     GVAGWLTLAILGAIMPFIVMTGMHWAFAPIFLAASIATPDVLILPAMLGSNLAQGAAS
                     MAVALKSKNNNTKQIAFAAGFSALLAGITEPALYGVTLKYKKPLYAAMIGGGLAGLFA
                     GLTSVKAYLFAVPSLIALPQFIYSDVPSNIVNALIVAVISVVITFVLAYIFGIDEEES
                     SSNLEVEAGVSNKKMIFSPISGEIIPLSDVQDKTFSDKLIGDGVAIIPSEGKVYAPFD
                     GKITNIFPTKHAIGLKSDEGVELLIHIGLDTVELKGQGFISHVEEGDRVFKNQLIFEM
                     DLNLIKTKGYETVTPVIVTNTNDFLDVLVLPNNQTIEHSKELLAIL"
     gene            complement(54397..55236)
                     /gene="licT"
                     /locus_tag="ACL8AS_000715"
     CDS             complement(54397..55236)
                     /gene="licT"
                     /locus_tag="ACL8AS_000715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator LicT"
                     /protein_id="HGS1228622.1"
                     /translation="MIIKRILNHNAVIAQSKKDIDILLFGRGIAFGRKTGDKVNPIDI
                     EKSFFLKNRDNMTRFTEMFINVPLELVYITEKIINLGKITLGNNFDEIIYINLTDHIS
                     SSIERYKEGVIISNPLRWEISKYYKEEFELGKRALQIIKKELGIELPIDEAAFIALHF
                     VNANLENNFQESYKITEIIMGIEKIIQDFYCTEFNQDSIDYYRFITHIKLFAHRLVEN
                     TTYCDDDDEDLLALMKNKYPREYECGEQVAMFIQTEYNYLLTSSELVYLMAHIRRLTK
                     NLD"
     gene            complement(55536..>55729)
                     /locus_tag="ACL8AS_000716"
     CDS             complement(55536..>55729)
                     /locus_tag="ACL8AS_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HGS1228623.1"
                     /translation="SSQLKSQKIKVSFTQSKIVTPILLVNKTIVWYGAMPLLGKVDEM
                     TILRLESASIVSELVAGLR"
BASE COUNT        15962 a        12549 c        10230 g        16988 t
ORIGIN      
        1 ctgaatatca aaaaagaaag gacaaaattt gtcctttctc gagcttagct ttttttcaac
       61 ccactacagt tgacaaagag ccaaaaaaag ttgagacata gcgtcttcaa cttttttaca
      121 ttactttaac tactgattaa agtgagttta catcaacttt gataccaaca ccttgagtag
      181 ttgtgatagt caagtttgtt acgtaagttc ctttagctgt agctggtttt gctttttgga
      241 ttgtttcgtt gaaagcttta aagttttcaa ccaatttttc agcttcaaat gatactttac
      301 cgatgattgc ttgaacgtta cctgcacggt cagcacggta agtgatttta ccacctttag
      361 actcttcaac tgctttagca acatccattg ttacagtacc agttttaggg tttggcatca
      421 agttacgtgg tccaaggaca cgtccaagac gtccaacaag agccatcata tcaggtgtag
      481 cgataactac gtcgaagtcc aaccaaccgt cgttgatttt agcaacaagg tcatcttcac
      541 caacaaagtc tgcaccagca gcttttgctt cttcagcttt tgcaccacgt gcgaaaacaa
      601 gaacacgtga agttttacca gtaccgtttg gcaataccat tgctccacgg atttgttggt
      661 cagctttttt aacgtcgatg ttcaagttgt aagcaacttc tacagttgcg tcaaattttg
      721 caaagttagt ttcttttgca agtgctacag cttcttctac gctgtatgct tttgtgctgt
      781 cgattttctc aagagcagca cgaagttgtt tgcttttttt agccattttc tattctcctt
      841 gtaagtggtt caatcgattt tcatctccca cgtcacttct cgaaatgatg aagtcttgcg
      901 ggttttcagt ctactatttt tctcttccta cggccttaag cccccttgct gtacccaagt
      961 acaagcctca gtcacttgcc tagtatgaaa agcaactaat agactgctgt gagattttct
     1021 actgtgttat tgattagtca acaacagtga atcccataga acgagcagta ccttcgatca
     1081 tacgcattgc agactctacg tttgctgcgt tcaaatctgg catcttagtt tctgcaattt
     1141 cttgtacttg tgcacgagta actgtagcaa ctttagtttt attaggtgta cctgatcctt
     1201 tttcaacacc tgcagctttt ttcaaaagaa cagcagctgg tggtgttttc gtaacgaaag
     1261 taaatgattt atcttcgtaa actgagataa caactggaat gatcatacca gcttggtcag
     1321 ctgtacgagc gttgaactct tttgtgaatc ccatgatgtt gataccagct tgaccaagag
     1381 caggtccaac cggtggagct ggtgtagctt taccagcagg gatttgcaat tttacaagtt
     1441 tttcgacttt tttagccatt tttaaatcct cctttgtggt tttggcggta attagagatt
     1501 tttacctccc acaagtatgt ttttcgcata cccattcatt atacactatt tatctggaat
     1561 tgcaagagaa aagtttattt tttatactca atgaaaatca aagagcaaac taggaagcta
     1621 gccgcaggct gctcaaagta cagctttgag gttgcagata aaactgacga agtcagctca
     1681 aaacactgtt ttgaggttgt gaatagaacc gacgcagtca gtaggtaaga cgacgctgac
     1741 gtggtttgaa gagattttcg aagagtatta atcgacgtag tctccgcctt caaagccata
     1801 gtattcttcc aaactgagac cacttgcagc aatttcttta gcttcttttc ctacataacg
     1861 caggtgccat tcctcagcca tatagcctgt ttccttttcc ttgcctttga gataacggac
     1921 aacaaagcca taatcagctg catgatccaa gagccattgg gctgcttttt cttctgtcac
     1981 caaatcacca tcagtcccaa tcacatcaaa ggccaagcct gtctggtgtt cgctatagcc
     2041 aggacgggca gagtaacggt cagctgctgc ctttccatct tggttgacat aatcttgata
     2101 gagcttggtc tgagtttcat aacttctaaa accactgtaa tgatcactaa tagggaaacc
     2161 tgcctcttgc atcgctttga tgagtttgac caactcagcc ttggctgttg gattttcccc
     2221 gggattatag tctttcgaca aaggataatg tttattggct acgatgattt cgtcgtattt
     2281 tccttggatg ctgtagtaat cacctttatt gaccacttct gcttttttct gggcagcccc
     2341 ttgagactta ctgccgactg tcccatcagc tttggctgtc tgttctgtct tagctgtgcc
     2401 atcttcattt tttgcttttt cttgtgaaca agctgctagg gttactgcca gcaaaccaga
     2461 taaaacgatg tatctttttt tcattttttc ttcctctatt cttcctctct tagaccgtgt
     2521 acttctctaa ttcatcggat aaggctttaa tcatttgttc caactcatgg gatttcactt
     2581 ggcaatcttc tgccgccatt tcttcccagg gcacccacca gactggacca cggccattca
     2641 atccatgacc cctcatatca cctgaccgtc ttggaaagag atgccagtga gcgtgggcat
     2701 ctccatttcc tagaagttca atgttcatct tttcagcttt aaacgttttg gcaacagctt
     2761 cttggaccaa actcatttcc tctagaaaac gaagttttac agaagtctcc atatgatgga
     2821 gttctgtgac atgctctttt gctagaaata aggtatagcc cttaaagtat tggtggtctc
     2881 caataacaac atagcctgtt tctagttctt ttacaaagta gggattttcc cctgccttga
     2941 tccattcaat tctttgacaa atcaagcaca tattagtcta ccaatgcact cttaagataa
     3001 gcatcgacca tacgctcagt cgccattact gaatcaatgt gtgttcgttc gtaagagtga
     3061 cttgactcaa taccagctcc aaggagagca tgctttactt ctgctcctgc agacatagct
     3121 gccgaagcat ccgaaccgta aaatggataa atgtcgagct taaatggaat atcttgctcc
     3181 ttcgccaaaa ctaccaagtg ttgacggaag tcatagtgat agggacctga agcgtccttg
     3241 acacagatag acactgtata ctcatccgtc tgctggtcat ctcccatagc tcccatatct
     3301 acagccagat attctactac ctgacttgga atattggagt ttgcaccgtg gcccacctct
     3361 tcgaagactg aaaaagcaaa atgagttgtt actggcaatt caatcccctc ttccttataa
     3421 acacgaagaa gattgagcaa aattgctgcg ctgaccttgt catccaagtg gcgagacttg
     3481 ataaaaccag tctctgtcac gacagttcgt ggatcgaagc tgataaaatc accgacctca
     3541 atcccaagag cacgagtttc tttttcattg cttactttta catccaaacg cacttccata
     3601 ttgtcctgcg tgcgttctgc agttcctgca tccttgtaga catggcaaga agtttggtgg
     3661 atgaggatgg ttcctgatac cttttgacct gtgctagcca catgaacggt acagttttca
     3721 ccttcaatca tgttccaagg aaaaccaccg atacggtcca atttaagacg accatctggt
     3781 ttgacagcac gaacaatagc acccagcgta tccacatggg cagtcacata gcgatgttgc
     3841 tcatcatttt gacctttgat ggtcacattg acaccaccct tagctgtgcg aactggctgg
     3901 taaccaaaac cttctagagt cttgactaaa taattcgaaa tttcacgagt gaagcccgtt
     3961 ggcgatgcga tggctgtcag ttctttgata tattctactg tttgattcat ttcttcacct
     4021 ctttcgctac ctattataac acatttatca tcggataaaa aaagaaaatc actcctgtag
     4081 acttggctac aaaagtgatt taagtgatta ttccatttca aaaacatcgc tttcttgctt
     4141 gtttggtaga accaatgaga gcaagattcc aacaatggct ggcaccaacc atgggagaga
     4201 tgccttggca aaaggaagaa cgctaacaag atttgcaaga aactcaacct taaacgagct
     4261 tcctagtacg cttgcaatgg caataactgt aaccacagca attgtcaact gcatacctgg
     4321 ttttgaaagg gcaacaaatt tgttgacaat gacaatcata acgatagcaa tcgtgattgg
     4381 gtacaagata accagtactg gaattgagta cttgataatc gcatcaagac ccaaattggc
     4441 aatagcaaat ccaatcaagg taaaggctgt cgcataaacc ttgtagctga tttgtgggaa
     4501 gcgctcatta aagaattcag ctgttgacac aatcaaacca acagtcgttg tgaagcaggt
     4561 tacggtaacc atagctgcaa ggaagagttg agctgttgag ccaaagattt cttgagtggc
     4621 ttgtgacaag atgtaaacac ctggtgttcc acccttcatc gcttcagctg gtactgggaa
     4681 atgatttcca agaaaaccta aaccgatgta aagagcgctg aaggcaaggg caacaacgat
     4741 accaacaacc caaatagttg aaatgtattc tttcttactt gaaaatccaa gttgtttcaa
     4801 ggtttgaact gcgattacgc taaaggccac tgaggcaagg gcgtccaaag tattgtaacc
     4861 ttctaggaaa cctgtaccaa aggcagaagc ttgataagca gctgaagcag cttgaggact
     4921 tgttccacca tatttgatag ctcccagaac gaccaagata acaatcaaaa ttgcaaagac
     4981 tggcgttaaa atacgtccaa tgcggtctaa gatttttgat ggattaagcg aaatcaaata
     5041 ggctgccgca aaatacagaa ccgtaaatac aatcaagcca agtcctttat ttgcatccga
     5101 caaaaggggg ctaatcccta cttcgtaagc tgttgtagca gtacgtgggg tagcaaagaa
     5161 tggaccgatt gacaagtaaa gaactgagag gtaaagagtc gcaaaccaag gcgctatctt
     5221 cgttgaaatc tcgtagatat atcctttagg atttagcgtt ccaataataa gggtcaagac
     5281 ggcgatacca acgcctgaaa agacaaaacc tgcgatggca ggaagaaaat gttctccaga
     5341 tagagcacct agagaaggcg gaaaaatcaa gttccccgca ccaaaaaata ttccaaacag
     5401 gagcaaacct gttagggtac cttttttagc cataaaaatc tccttcatat ttataaaata
     5461 ctgacctagt ataccacgat taggagtctg aaaaaagcat cacgaggcaa atattaaatg
     5521 ttttcaattt tcttaaaaat aagaattatc taaaaataaa actctcctac ccagtccaca
     5581 ccaagtagga gaaatgcaaa attttaaagt tcttcaaagg ctaacatgcc accctggaca
     5641 ttgataacat tataaccttg ttctaatagg aattggcaag cacgcgccga tctcattcca
     5701 gatttgcaaa taatataatg caagcgatct ttgtccaatt aatcataact atcagccaat
     5761 tgactaagcg gtaggttgtg ggcaccttct aaatgaagag ctgcaaactc atccacttct
     5821 ctcacatcca ctagagaaag ctggtcgttt tggtaaagct ggtaaaatgc gtcaaaggct
     5881 atttctttca ttctttttct tctaatactc ttcgaaaatc tcttcaaacc acgtcagcgt
     5941 cgccttaccg tgcgtatgtt accgacttcg tcagttttat ctgcaacttc aaagctgtac
     6001 tttgagcagc ctacgactag cttcctagtt tgctctttga ttttcattga ctataaaatg
     6061 gttttaattc tttttttcaa atctggcact acttctgcct caaaccaagg atttttggcc
     6121 atccagattt gatttcgtgg tgatgggtga actagcggaa aataggctgg cagatagtct
     6181 ttatagtgtt tcaccctctc cgttaccttc ccactgattt tctcctgtaa atagtaggct
     6241 tgggcatatt gcccaatcaa gagggttaac tgaatatcag gcaattcctg taagagctgc
     6301 ggatgccatt tttctgcaaa acctgtacga ggcggaagat cacccgactt gccatgtcct
     6361 ggaaagtaga aatccatagg caaaacagca aaataacctg aattgtaaaa ggtatcttca
     6421 tccacaccta gccagtcccg caaacggtca ccacttttat ctttccagta aaggcctgct
     6481 tcttgagttt taagtcccgg agcctgaccg atgatattga tgcgagcagt ttttggcgct
     6541 gcaaagagag gctcaatgcc acgctctgta tagctggcat tctgcgaatc cgccatgata
     6601 gcctgtttga ttctttcgat ttgagacatc tactttccct ccaaaaagaa gtccaagcat
     6661 aagatctcag acttctatcg ttttatttga tcaattcgta aatagcttcg gcataaattg
     6721 ctgctgctcg gaagagatcg tccaaggcaa taaattcatt ggcttggtgc atggtatcaa
     6781 ttgagtctgg gaacatagca ccataggcaa ctccgcgctc taacaagcga ccaaaggttc
     6841 caccaccgat gacttgttca tgacctttaa ggcctgtttg tttttcatag acattcaaca
     6901 aggtttgcac aagtggatct tccattggca catagtgagg ggtatgacca tgttctgata
     6961 gactgacaga agcaactggc aagttttcta ggattgactt gatttgttct ggacttgttc
     7021 cttttggata gcggatgtta agggcaatgg tattatcagc acttgtttca tcgaagcgga
     7081 agacgccggc attcatagaa agagcaccca tcttttcatc cacatgagca atcttaagat
     7141 tttcaccctc atgatcgttc aagagaattt tacctgcgat gtcaaggtag tctttggctg
     7201 gaccagcaaa gccaaactgg ctgaggaaga gggcaaggta agttgcgcca ttgacacctg
     7261 aagcaggcat agcaccgtgg gctgatttac caatgatcgt caccttgtat ttgccagctt
     7321 cttcttggag ttctcctcta agtttgtgtt ctgcaacaaa ggcatctagt ttagcttgca
     7381 agtcagccaa atcacctgaa acgactgctg ttgctgattc tggtaccata ttttcacgta
     7441 aaccacctgt aaagctgtga agacgggcag cacctgtatt ttctcctgca aagtggaggt
     7501 attccgtgat atttcctttt tcaccattga tgattggaaa ttcagcatct ggagagaaac
     7561 caaagtctgg cttcgcaagt cctacgtgct caaagtagta gtccatgtct gcccagcctg
     7621 attcttcgtc tgttccaacg atgaagcgaa ctttcttaga agttggaaga cccaattctt
     7681 tgatgatttt caaaccatag taacaagctg ttgtaggacc cttatcgtcc gaagccccgc
     7741 gcgcataaag gcgaccatct ttgatagttg gtgtgtaagg atctgtatcc caaccgctac
     7801 cagctggaac cacgtccata tgggcaaaga ttccgagaac ttcttctcca tcaccaaact
     7861 caaaatgtcc tgcgtagtta tcgacattct tagttgggta gccatcacgg tctgcgattt
     7921 caaggaattt ttccaaggct tttactggac caggtccaaa tggatgttgg gcatcagcct
     7981 tgctatcatc acgttctgag ttgatttcca aaaggctaaa caagtcagcc aagaggtctt
     8041 ctttgcgttt ttctacttct gctgtaaaat caattgctat cattttttct tcttcctatc
     8101 ttttttcaat gatttcatct actggcaagc ggtagcttgg ttccaatttg tcgtctgtgt
     8161 aacccactgt gatcaagagt tctgggcgga aacggtcttc gatttccaaa acttcattaa
     8221 cttttgattt gtcaaaacca aggataatat tggaaccaat tccttggtct gtaagagcga
     8281 gaaccaagtt catagcaacc aaacctgcat tgagtgctag gtagtcgctg acttgttgtt
     8341 cattgtagcg tgcaaattca gctggcaaat ttttcatgaa gtattgaagt tgttcttctg
     8401 agaaattgtt agcaccacca actcgggcaa tcttacgagc gcgtttggca aggtctgtat
     8461 ctgtaaatag ggcaatggtt acaggtgctg atgatacctg ctcaaagttt gaaccataag
     8521 ccaactttgc cagttcagca tttttctcac gaacaactac aaatttccaa ggctggctgt
     8581 tgtggacgct tggcgccaag gttgcaattt cgatagccgt acgcacatct tttggatcaa
     8641 caggcttatc agtgaaatgc ttggtcgcat gacgtttttt atttaattca agaaatttca
     8701 taatcgattt ccttttctaa ttctactgct tccattctac cataatttga aagagcttgc
     8761 agggattttt catgattaag tttttctatc acagacataa aagatatata ttggtttatc
     8821 aggaaagttt ctgataaact agcaagtact ttacatttga atggagacag tatgaaaaaa
     8881 tttagcctat tactagctat cctaccattt ttggttgcct gtgggaatca agctacaccc
     8941 aaagagtcca gctctcaaaa gacaatcgtc cttgctacag ctggcgacgt gccaccattt
     9001 gactacgaag acaagggcaa tctgacaggc ttcgatatcg aagttttaaa ggcagtagat
     9061 gaaaaactca gcgactacga gattcaattc caaagaactg cttgggagag catcttccca
     9121 ggacttgatt ctggtcacta tcaggctgcg gccaataact tgagttacac aaaagagcgt
     9181 gctgaaaaat acctttactc gcttccaatt tccaacaatc ccctcgtcct tgtcagcaac
     9241 aagaaaaatc ctttgacttc tcttgaccag atcgctggta aaacaacaca agaggatacc
     9301 ggaacttcta acgctcaatt catcaatcac tggaatcaga aacacactga taatcccgct
     9361 acaattgatt tttctggtga ggatattggt aaacgaatcc tagaccttgc taacggagag
     9421 tttgatttcc tagtttttga caaggtatcc gttcaaaaga ttatcaagga ccgtggttta
     9481 gacctctcag tcgttgattt accttctgca gatagcccca gcaattatat cattttctca
     9541 agcgaccaaa aagagtttaa agagaaattt gataaagcgc tcaaagaact ctatcaagac
     9601 ggaaccctcg aaaaactcag caatacctat ctaggtggtt cttacctccc agatcaatct
     9661 cagttacaat aatactcttc gaaaatctct tcaaaccacg tcagctttat ctgcaacctc
     9721 aaagctgtgc tttgagcaac ctacggctag cttcctagtt tgctctttga ttttcattga
     9781 gtataagata tactaaaagc gatgggatca gccaatcgct tttttagttt gcattggcta
     9841 ttttaggaaa ctcttacaaa aaatcaaaaa aattcttcac atcctctaca tacccatgct
     9901 tttctattaa gctggctaat agttccagat tgtgcccctg atagttatcg tcacgacgca
     9961 gttcttcata catttcgata aagggaagcc ccttggactt ggccaattct aactcagctt
    10021 cgtaatcata agcaacttta cgaaattgga tattgagtaa ttccccatct tcaacttcta
    10081 tcacggcata ctgggcacgg tgatttttta acgcctccca attaaaatag ggcatgccaa
    10141 tcgaccctgg attgatgatt tgttgccctt gacttccata acgaagcaac tgcttgtgaa
    10201 catgaccata aactgccacg tccgtttccg catctagcag ttggtcaaat ttctctgtat
    10261 cattctcaac tagcaagtca ccaccatagt ttttgtcagg taaattatga gagatagaaa
    10321 agcgcaatcc gtcaatttct ttcttttcca gcaaaggcaa gcttcgtagc cagacaatcg
    10381 ttgcaggatc cattcgctcc atcaaatact gtgtcatacg caagagctga acttcctgtg
    10441 ggtcttctaa gccatattgc ccatctaaag cctcaaggac acaatcatcc caattgcctc
    10501 gaacacttgc cgtgatagga agttccttta acagagcgac caagtcattt gcacctggac
    10561 cagggaggaa aatgtctccc atgagccaat attcactggc tccttgagtt ttagcatctg
    10621 caatcactgc ttctagcgcc gtcgcattgc catgaacatc tgataaaatt gcgattttat
    10681 ggtttattgt ggtttccttc cgtttggtaa tctactcttt cttccgccac ttgaagcaag
    10741 atttctgttt cctgcgggtt caacttggtt tgcacagcct ctgctactgc tcttggtact
    10801 ccaacttcga caatctcatc cacactggct tccttgattt tggtcagaga cttgaagtgc
    10861 ctcatgagat tttgcttgcg tttaggtccc agaccatcaa tcccatccaa ttgagatgag
    10921 aaagaatttt tggagcgcag ttggcggtgg aaggtgatgg caaagcggtg cacctcatct
    10981 tggatgcgtt ggaggaggaa aaattcctga gaattgcgag acaagtccac cacttccagc
    11041 ggatctccaa agagcaattc atgggtttgg tgcttatcat tcttttgcag acctgcaatt
    11101 ggaatatcca agcccagttc ttcttggatg acttgcttag caatattgac ttgaccttgc
    11161 cccccatcaa tcacaatcaa atctggagga gtcaaagcct cacgctgtac tcgaccatag
    11221 cgtctgcgaa tgacctctcg catactggca tagtcgtctg gcccgactac ggtcttgatt
    11281 ttatacttac ggtaatcctt cttactaggc ttgccgttga caaagaccac catggctgaa
    11341 acaggactag ttcccatgat gttggagtta tcgaaggact cgatgcgaac tggggttggg
    11401 atttgaagca agcgtcctag attttcaata gctccttggg tcttctcgac agatttctct
    11461 agcaggttga acttctgctc taggctaaca cgggcatttt ttatagctaa attgaccagc
    11521 tgctttttct ctccacgttg aggcttaaga atcttggaat ccaccaaggc cttgacagcc
    11581 tcttcgtcaa tatcctgcgg aatcagtacc tcattgggaa ctaggtgaga tttttcttga
    11641 tagaattgtc ccacataggt caagaaatcc tcatctggat cattgaagta ggggaagaga
    11701 ttgacatcgc gctcgatgag cttgccctga cgaacaaaga aaacctgcac acacatccag
    11761 cccttatcca catagtagcc aaagacatcg cgattttgga gatccttagc catgacccgt
    11821 tgcttggttc gaagcgttcc aatagcctga atcaggtcac ggtattccgc cgcacgttca
    11881 aactccatag tctgggctgc cgctgccatt ttgcccttta gctcatcaat gattttgtta
    11941 tcctgccctt tcagaaaatc agaaacctcc tgggccatag acttgaaata agcctcatcc
    12001 ttcttacaga tggtgtgggc catacactgg ccgatatggt aataaaaaca gaccttagag
    12061 ggcgggttgg tacattttcg aaaagggaaa atcctatcta gaagtcgctt gatttcattg
    12121 gctgccccca catctggata agggccaaaa taaagaccac cgtccttttt gacctgacga
    12181 gtaatgataa gccgtggata gcgctcattg gtgattttga taaaaggata agacttatca
    12241 tccttgagca tgatattgta cttgggctta ttttccttga tcaggttgat ttccagcaga
    12301 agcgcctcaa tattggactc agtgacgata aattcaaaat ccacaatttc agacaccaga
    12361 gcctctgtct tggtatcatg acttccacga aaataggacc gtactcgatt acgcagattt
    12421 ttagcctttc ctacatagat aatggtgcca tttttatcct tatgaatgta gcaaccaggg
    12481 ctggtcggca agagctctag ttttgattta atcaagttgt tcatagttcc attatagcaa
    12541 aaaaagtagg gaaagatagt accctactca ctagtctcat atatttttcg gaggtttgca
    12601 acatcctctt cctggatacc ataaaaggaa cctgctggtt gcatgacaga cttctcatct
    12661 gtatggtcca agccaatcgc atgacctaac tcatgttctg ccgtatggac aaggcgttca
    12721 taggagtagc catagtatgg attggacaaa taataatgat tcaaccgcac cgttacggac
    12781 aagaattgcc ctgttaagag attagtttga ctttccgcct ctcctgccac aggagtgcct
    12841 ccgtcgttca tctccgtagc cgtaatatcc gccttactag actcagtcac gagttcaaag
    12901 ttaaaagcac cagtttgatt ccagttctgg atcgcttcta aataagcctc ttgaaagcgt
    12961 gaatccatct gcggatccag gtaaatacga gcagaggcct gtgcccacct tccttcagaa
    13021 tgctggtgac tatctgtctg gcttaactta ggcagttgcc ctgttttctc ccattggtca
    13081 atactttgtt gaccaatttt tactgaccgt tctgcttgct ttagcgctcc ttgaaaatcc
    13141 ccgttcagat accagagaag tccgaaagca agcacacata agagcacaac tatccaaacc
    13201 agacgccaaa acaaacgcca cacaaaagaa aagaaagccc ctatcaaacg aaaaagccag
    13261 cgcatgtctc tccacctttc tagcaaataa gaattatttt actaaaagaa gctaaaagaa
    13321 atctaaatac tgactttttc atcttaacgt cctactattt ttttgagtaa ctggatagct
    13381 ttgtatttta aaggcgatgg atggtaacgg aaagtacccg ctttgcgtac aatatagcca
    13441 ttaaaattct gtttaaaacg caaaacacca tcacttccat caaaaatccc ttgaatgcct
    13501 aggaagttgt atttaggtat tccacgtttt atgctttcca acataacata tttttgaagc
    13561 agggcagggg catagaactt attaaactca gtgtaggaac cactaaagag ataagtcgtt
    13621 tcctgaggca tataaacaaa taaactccca gctaaaacaa tatcttcttc tccatatttt
    13681 tcaatcaagt ctcgcgcttc tgcttttcga acttcaaacg tttcaaattg actagaatat
    13741 tctctcagtt gattttgttt tttctcagaa tgaggatttt tactcaaatc aagtcgcaac
    13801 ttgtccaagt tttcttctag tttactttgt tcaccttgca atttgctcat atagtccgaa
    13861 aaatttaagc ttgctatgag aaactccgct tgttctccaa aagtatcata aaaatgctca
    13921 taatattcta aacttttatc actatattct ctacgttcag aggtttcttt tgttatattc
    13981 ttaaaaatcg atagttcttc acgttttaac tttttcaacc gaatgccaaa ggtttcagcc
    14041 tttttcacca agggtttacc ctttttgcta aaacttttaa gcaaactctt ttcagttaat
    14101 tcagttaaat ctttatagta taaccaatct ggttctccac ctgggtaacc tgttgttaag
    14161 ccatcaaatt gataacctaa atcagtcaaa ccttgaataa tacttttttt ctcagcatct
    14221 attgaattac cttggctatc aaaagtttga taagtttcat aaggttttac aagcaactct
    14281 aatacaccat tttgcttggc atattctttt aactctgcat aaaaaactgg aagagcatct
    14341 tgttgggtat aaatcggccc cgaattgagt tccatatgca gaccacccag catgggcaag
    14401 ctataaacca gagctgcaac ttgaatttct ccttcttgtt tcaaagcaag ataaacaatt
    14461 cgagcccctc ttttttctag caaatccccc atctggacag attgcataaa ggaacgagaa
    14521 gaaacctgat cagaataagt ctgaaactct tctttcgtga gtgttgttag tgccatatac
    14581 ttactttcta tgtttttttc ttaatgtttt acggaaatca agagcaagtc ttaacagagg
    14641 atagagagga tgagtgggca ttgtaaattc acccaagtat tcttcaatcg ttggattaaa
    14701 tttttcctta aaatgataaa gtccaccatt gagagagttt tcaacaccac ctaaattttg
    14761 ccaaaccata cctcgctcaa aggcatagcg agccgtttca taccatgtta aaattggtgc
    14821 attgtaacgt ttaaaatcat catccatacc agcatatata ttgacagagg tagtaccaaa
    14881 ttccaaactc aaagtagccg ctaaaggaac tctcgcttga cctacatcta tatattcctg
    14941 caagaaggtc aattcctcta acaaacgttc tttttccttc ttctgcgctt ctacttttga
    15001 aattcgagtc gactcagtaa aggtctcttc caaggctcta tttttcgcta actgttcttc
    15061 taattcttgc gaacgtttag aaacatccaa ggtggccaag gtgatatagg ccttgtcctt
    15121 aaaattatct aacaattttt tataataggc ttcattcctc aaatgaatct cttttcgctt
    15181 ctcagttttt ttcatcaact ccgaaaatga atctaatagt tccagtccac catattgaat
    15241 ctcaagccct ttgtttcgtg ctgttcgaat agcctgtttt gttgacttgg aaagtttatc
    15301 ttcttcaaaa ttttccttgt atattttcgc ctgaatacga ggttgaatgg tgtctcccat
    15361 ttcctccgtt tttcctgacc accttactcc catttgttgc aaactatcaa taatagccag
    15421 attttcagga aattctgtct tttcctgatt gattaaactt tgagataggc aaatacttgg
    15481 gtcaaaagtc acaaaaaccg ctctcttact gcgagcatag gacttaatag actgaatgac
    15541 aaaattcaag agttctttat ccccataatc caatataggt cctcttggga tgtaaaacat
    15601 tttatagcct agcggaagag ttctaatcaa aatactagct gtcgccagta atttttcttc
    15661 cctgtaaaca ccaaacttct catgttgcca attagactta acttcctccc aagcactact
    15721 ttgtaataca ttggctaatt catgttcttt gacaaactga tcatattcta atgtgggaat
    15781 gccaatttga taacggtaca tttcctaatc tctttcctcc agtattttat tactattcta
    15841 ctactttcgt ttgaaaagtc tagtgaaaac atattttatt ttagttctac tccccctatg
    15901 ctgaagttca aactaagtca gtctctcttc taatttgaaa tcaattggta gggttgttaa
    15961 aaaaacttcc aattgttttt cccagtagta ccactcgtga gttccagcac tatggctata
    16021 ggtcacatca aaacctagtt ttttgagatt tttcactgcg agattattgg cttcgtacaa
    16081 gaaatcctgt tcgccacacc acgcccaaag tttggtcttt ttatccgatt ttttagccag
    16141 actttcaaga gaatagggac tagttgtcca gtctctaatc tctccaaaaa cacctctcca
    16201 gtaggctgga cttcccagat tttgactttc aggagaaaag ttttgaaagc tgagggcacc
    16261 tgaaaaacta gctgcatgag aaaaacgatt tgtcgtaaga gccagtttga agcagccgta
    16321 gcctcccata gaaagaccag cgataaaggt cttttcacgc ttgctagtca tattagggaa
    16381 gaagcgtttc agaacctgtg gcaattcctc tgctagagcc gtgtagtagt caaaaccata
    16441 ctgggtatcg gtgtaccaac cattgctggt attgggcata acaacgatga gattagttcc
    16501 tcgaagcaag cgttctacat tggtccgctt aagccaacta ttatgatttc cagacatccc
    16561 gtgcaaaagg tacaagacgg gaatatcttc acactctggt tcttccactc gattggcatc
    16621 agggtagagg acattcaccc cccactccat atccaatact tgtgagtaat actcgatttt
    16681 cattactgcc atgattttct ccttctattt ttctataaga aaaagccgaa actcgacttt
    16741 ctctctgttt atttcaacga ttattttgct tccatgacta ctggtaaaat agctggacga
    16801 cgcttggttt ggtcaaagag atacttggtc aaattatctc gaaccttccc tttaagatct
    16861 gcccagtcaa agtcatctcc ttgaagataa tcttctaccg tttggttaat caattctgaa
    16921 ctttcacgga gaatatcgcg actcttcttg agataaacaa atccacgcgt gtgaacacga
    16981 gccctagcca caattttctt ctcacgacgg ttaactgtaa tagccacgat gaaaattcca
    17041 tcctctgaca agaccttacg gtcacgaaga acaacatttc caacatcacc aatggcattc
    17101 ccatcaatca agatatctcc tgctgaaacc gatccagctg gaacaaagtc tccattctcg
    17161 taagccatgg tcgtcccctt tttaggaatg aaaatgcgtt ctggcaacat cccaactgcc
    17221 atggcagcct tagcgtgagc atccaactca cgatactccc cttggacagg gaagaggtac
    17281 ttaggttgca aaagattgat catcagctgc aaatcacgca catttccgtg ccctgataca
    17341 tgtaaacttt gggtaatcaa tttgacaacc ccacctgcct gataaatcat attttccaca
    17401 cgcgcaacaa aggcttcttt agcaatagac ggagccgtag caatatagac caggtcccca
    17461 tccttgattt ctacataacg atggcgacca atcgacatct tacgaagtcc attgataggt
    17521 tcacccatac gacctgtctc aagaataatc aactcatggt cttcaaagcg agacatatct
    17581 ttaggcttaa tcaagagaat ttcgttggct aaagacaact tcttaagacg aatcgctgtg
    17641 cggacgatat tttcgatatc aaatcctgtc aagacgatac gtcgacctgt tttatccgca
    17701 gcgtcaaaaa tctgctgaat acgagaaaga ttactggaaa cagctgcaac gatgatacga
    17761 ccttcccagt cagcaatagt ttgggtaatt tcatccctaa cttcactttc actagccacc
    17821 tgaatattgc tgtctgcatt ggccgaatca ctgaggagag ccaggacgcc gtcacgacca
    17881 atctctgcca aacgagcaaa atcagttgca taagattcac tagccgtttg gtcaaatttg
    17941 aagtcacctg tataaacgat acttccttcc gatgtcttca agacaattcc cagactctct
    18001 ggaacggagt aagtcgtagg gaagaaggaa accactgtcc caccaaaatc aatctccgta
    18061 ttctcatcaa tgacatggaa atcattaaat ttcttaacgg catcatttcc tttgacaaag
    18121 agctttgcca actcaatggt caactcagac ccaaatacag gaactttagc ctctgccaag
    18181 agataaggta gagcaccaat agcatccgca tgcccgtggg tcaagaaaac cccagcaata
    18241 cggtcgctat tttcaaaaag gtaatccatg tttggaatca ccacatcgac ccctaattgt
    18301 tcattttcag gatattttaa ccctacattc aaaacaaaaa tggactctcc aatttcagca
    18361 atgtacatat tttttccatt ctcacgcaca ccaccaagtg ttgttaaact gatattactc
    18421 atttttcctc caaaatctta gtttatcttg attatagggc aactctaccc tcttattcta
    18481 aaagttctga tactttcagc cgaatctttt cctaccatta taccattttt ttgatgattt
    18541 tcaaaatgaa ggtctgtttt caaaaaagag ttgatttccc aactctttcc taacttctac
    18601 tctttttcca tcaaaaaatc ataaatttct tgcaccgtac ccagcgccat catttcttgg
    18661 tctttaacgg tttgtttgag attttggtaa atttgacttt ctcctatctc ccgctttggc
    18721 gcctctttat tgactgtcat cacaccatct tttatcgtca caaagcctag ttcttcaaat
    18781 acttgaatca tcttgaccag caagatttgt tgaatattaa gatatgcagc caaatctttc
    18841 agcttgtagc gaatatcaaa ctctgggaac tggtaaatag tcttgtacaa tttagcaaac
    18901 tgatctctag tcccataacc tgtcagataa taggtcttgt caatatcatt tttgaaatag
    18961 acagcagaga aatgctgttc ctgaaaaatg gtcttcagct gagtaatatc ctctggaatg
    19021 ttttttacga caacagcttc actagctgca agatttggca gttctccagg aaaatccaag
    19081 actggaacac cttctggcaa gactgcattt tttccacgaa tgttaaaaag ttgaacacct
    19141 tccactcgcg catccaccat catcaactgg agggcagttt ggccattcca ttggttgaca
    19201 gacaatttaa ccgctaactc tagattcttg gtttgagaaa actctgtcgc ccatctgcct
    19261 tgaccaaagg ctaccacttc aaaactcgcc tcacccttgg aaattttcag ctttagatgg
    19321 gcattacctg cccccatagt acgagcactt tcgacctgaa aattcttgat ataaaaaata
    19381 ggtttctgat tatccattcc aaaaggagct aaacgttcaa aacttttgac cgtttccaag
    19441 ctaagtgcct ccaaatccaa ctcttcatct aggtttaact tattcttgcc accagcatct
    19501 gcaccttttt cacgaacata atcttccaaa acctgagata aatctgagag ttgctcaact
    19561 tccagcgtca tacccgctgc acctgcatga cctccaaagg cgatgaagag gtctcgatgg
    19621 ggatccagag cttcaaaaat atcgaccgct tccacactac gagcactgcc cttggcacga
    19681 ccgtcttcta tattaagaac aatgactgtc tgtcccaatt cttccaataa acgaccagcc
    19741 acgattccta gaaccccagg attccagcct tccttggcca agacctgaac cttcttctca
    19801 ggatccacca tggtcttggc ttcttcatag atagactgaa cgatttcctt gcgctcttcg
    19861 tttttctggt gaatcataag ggcaatctca tgcgcttcct catcatcaaa tccagtcaac
    19921 aaatcaatgg caggattggg atcatccaag cggcccaagg cattcaaacg aggagcaatc
    19981 tggaaaccaa ccgtttcttc tgttacttcg ttggcagcaa tcccagccat gtccagcatt
    20041 tcttgcagac caatgcgctg ggtatgaccc aacatttcca gaccatattg aactaagata
    20101 cgattttcat ccgtcagact caccatatct gcaatagttc caatagcgac caaatcaagc
    20161 aattccactt gcacttcttc taacagggca caagccaact tgaaagcaac tccacaacca
    20221 gccaaatatt taaaaggata atccgcatct ggatgttcag gatggacaat agcataagca
    20281 tctggcaggg tttcaggcat ggaatgatgg tctgtcacaa tgacatctac tcccatagac
    20341 tgagccaatg caatagcctc atgaccagca accccattgt ccaccgtcac aatcaaggaa
    20401 atcccttctt gctcgataaa gtatttataa acactagcat tagggccata gccatcggta
    20461 aaacgatttg gcaggtaaac tcggcactca gcaccaagtt gttccaaact ttccttcaca
    20521 atagaagccg aagtcatgcc atccgcatca tagtctccat aaacgagaat attttcccct
    20581 tcttcaatag cctgacgaat ccgctccact gccttgtcca tatcatggag cagataagca
    20641 tcatgtaagt cctccaagga aggttctaaa aacttcttca gactttcttg gttctgaatc
    20701 cctctctcaa acaataaccg agccacctca ggacccagtc cagccttctt ggctatcttt
    20761 gtaaaatccg catcttctac ctgcagggca aactgccatt cataagtagg tgttatcaaa
    20821 aagacatcca ctctttctaa gaattctatt gcttcattat aacatgattt agacgttttc
    20881 tctatccaga ttgctttttt ataacatttt atagtatatt gaaactagaa tagtacacct
    20941 ctacttctaa aatattgtta gaaatcgatt tgactgtccc gatcgatttt tcctgttctt
    21001 atttcactat agtgaatttt ttcagatatg atttgacaag aacattcttt tattgtagaa
    21061 tcatgtcata aaatctaaca caagggagag ctctcatggc tttagtagaa tttaaaaacg
    21121 tcgaaaaata ttacggagac taccatgcac tccgcgacat caatctccgt tttgaaaaag
    21181 gacaagtcgt tgtcctactc ggaccatctg gttctgggaa atccactctt atccgtacca
    21241 tcaatggttt ggaggctgtc gacaagggaa gccttctagt caatggccac caagttgctg
    21301 gtgccagcca gaaagatttg gtacctcttc gcaaggaagt cggcatggtt ttccagcatt
    21361 ttaacctcta ccctcacaaa acagtgttag aaaacgtaac actcgcaccc attaaagttc
    21421 taggaattga taaaaaagaa gctgaaaaaa ccgcccaaaa atatctggaa tttgtaaata
    21481 tgtgggacaa gaaagattcc tatcccgcca tgctatctgg tggacaaaaa cagcggatcg
    21541 ccatcgctcg tggtcttgct atgcatccgg aactcctcct ctttgatgaa ccaacatctg
    21601 ctcttgatcc tgagactatc ggagatgttc tagcagttat gcagaaactg gcgcatgatg
    21661 ggatgaacat gatcatcgtt acccacgaaa tgggctttgc tcgagaggtt gcggaccgca
    21721 ttatctttat ggccgacgga gaagttttag tagatacgac agatgtcgat aacttttttg
    21781 acaatccaag cgaacctcgt gcccaacaat tcctcagcaa aattatcaac cacgaaagtg
    21841 acaaagtcaa ataaggaggc gcctatgaaa aaaaaattct ttttatcagc attattgatt
    21901 agccttttcg gccttgctgc tgccaaacca gtccaggctg atactagtat cgcagacatt
    21961 caaaaaagag gcgaactggt tgtcggtgtc aaacaagacg ttcccaattt tggttacaaa
    22021 gatcccaaga ccggtactta ttctggtatc gaaaccgact tggccaagat ggtagctgat
    22081 gaactcaagg tcaagattcg ctatgtgccg gttacagcac aaacccgcgg cccccttcta
    22141 gacaatgaac aggtcgatat ggatatcgcg acctttacca tcacggacga acgcaaaaaa
    22201 ctctacaact ttaccagtcc ctactacaca gacgcttctg gatttttggt caataaatct
    22261 gccaaaatca aaaagattga ggacctaaac ggcaaaacca tcggagtcgc ccaaggttct
    22321 atcacccaac gcctaattac tgaactgggt aaaaagaaag gtctgaagtt taaattcgtc
    22381 gaacttggtt cctacccaga attgattact tcccttcacg ctcatcgtat cgatgccttt
    22441 tccgttgacc gctctattct gtctggctac actagtaaac gcacagaact actagatgat
    22501 agtttcaagc catctgacta cggtattgtt accaagaaat caaatacaga gctcaacgac
    22561 tatcttgata acttggttac taaatggagc aaggatggta gtttgcagaa actttatgac
    22621 cgttacaagc tcaaaccatc tagccatact gcagattaag gaggacaccc catgacagat
    22681 ttatcatctt ggacagccta ttttcaggat tttggacaat ttttcaatgg tttcctcttt
    22741 actcttgccc tagcgattgg atcctttatc ctcgccatgg tcttaggaat cttctttggt
    22801 gccatgtcaa ccagtaaacg tccaatttta cgcattttag ctcacatctt tgtggaattt
    22861 taccaaaaca ctcccctctt ggtgcagttt gttattgttt tttatggcct acctcttatc
    22921 agtgaccata ctatcatgat tccaatttat tggacagctg ttctctgcat gggactctat
    22981 cacggcgctt atatcgctga ggttattcgt tcagggattc agtctattcc tagtggtcag
    23041 atggaggccg ccttgtcgca aggttttacc tatatcagtg ccatgcgctt gattatcttg
    23101 cctcagacct tccgcatcat tctccctcca ttgaccaacc aaattgttaa cctcatcaag
    23161 aacacctcta ctgtagctat catctctgga gtagacttga tgtttgtgac taagtcttgg
    23221 tcggctctca acggaaacta tatcccagcc tttttaggtg ctgctcttct ctactttgct
    23281 ctatgcttcc ctgttgccca gtttggtcgc aagatggagc aagccaacaa aaaagcctat
    23341 tcactttagg aggttactat ggaatctatt ttagaagttt taaccccaga taacctagtc
    23401 tttatcttta aaggatttgg cttgaccctc tatatttctc tgattgccat catcctctct
    23461 actatcatcg gtacggtgct agctgtcatg agaaatggca aaaatcctgt cttacgcatt
    23521 atttccagta tttatatcga gtttgtgcgc aacgttccca accttctctg gatttttact
    23581 atctttttgg tgttcaaaat gaaatccaca ccagcaggta ttacagcctt tactctcttt
    23641 acatcagcag ccttggctga gattattcga ggcggtctca atgccgtaga caagggacag
    23701 tacgaagcag gaatgtcaca aggcttcacc tcagcccaaa tcctctacta catcattctc
    23761 ccacaagcca tccgcaaaat gctaccagcc atcatttctc agtttgttac cgtgattaag
    23821 gataccagtc tcctctactc tgttatcgcc ctacaagaac tctttggagc cagccaaatt
    23881 ctcatgggcc gttatttcga accagagcag gtcttcagtc tttacatcct gattgccctc
    23941 atctacttca gctttaacct agcaatttct agcctgtctc atatgctagc caaacgttgg
    24001 caacaagctg cagaataata ctcttcgaaa atctcttcaa accacgtcag cttcaccttg
    24061 ccgtatatat gttactgact tcgtcagttc tatccacaac ctcaaaacgg tgttttgagc
    24121 agcctgcggc tagcttccta gtttgctctt tgattttcat tgagtataaa cagccactct
    24181 ccagttcaat tggagagttt tttgatgaga gtagatattt atagacctca atttgacacc
    24241 atacattttc tatgataaaa tgtaacaaat tcatttacaa caaatcgaaa tctaaatgaa
    24301 atggaatttt ctatgaaatc agtcaaagga ctactcttta tcatagctag ttttatcttg
    24361 actcttttga cttggatgaa cacttctccc caattcatga ttccaggact agctttaaca
    24421 agcctatctc tgacttttat cctagccact cgtctcccac tactagaaag ctggtttcac
    24481 ggtttggaga aggtctacac cgtccacaaa ttcacagcct ttctctccat catcctacta
    24541 atctttcata actttagtat gggcggtttg tggggctctc gcttagctgc tcagtttggt
    24601 aatcttgcca tctatatctt tgccagcatc atccttgtcg cctatttagg caaatacatc
    24661 caatacgaag cttggcgatg gattcaccgt ctggtttacc tagcctatat tttaggactc
    24721 tttcacatct acatgataat gggcaatcgt ctccttacat ttaatcttct aagttttctt
    24781 gttggtagct atgccctttt aggcttacta gctggttttt atatcatttt tctatatcaa
    24841 aagatttcct tcccctatct aggaaaaatt acccatctca aacgcttaaa tcacgatact
    24901 agagaaattc aaatccatct tagcagacct ttcaactatc aatcaggaca atttgccttt
    24961 ctaaagattt tccaagaagg ctttgaaagt gctccgcatc ccttttctat ctcaggaggt
    25021 catggtcaaa ctctttactt tactgttaaa aattcaggcg accataccaa gaatatctat
    25081 gataatcttc aagccggcag caaagtaacc ctagacagag cttacggaca catgatcata
    25141 gaagaaggac gagaaaatca ggtttggatt gctggaggta ttgggatcac ccccttcatc
    25201 tcttacatcc gtgaacatcc tattttagat aaacaggttc acttctacta tagcttccgt
    25261 ggagatgaaa atgcagtcta cctagattta ctccgtaact atgctcagaa aaatcctaat
    25321 tttgaactcc atctaatcga cagtacgaaa gacggctatc ttaattttga acaaaaagaa
    25381 gtgcccgaac atgcaaccgt ctatatgtgt ggtcctattt ctatgatgaa ggcacttgcc
    25441 aaacagatta agaaacaaaa tccaaaaaca gagcttattt acgaaggatt caagttcaaa
    25501 taagtaatca tactctcctg ggatttccca ggagagtttt ttatagccaa atgaaataag
    25561 accggaacga tggaattttg gcattcaaat caattgataa gaatatttta tagtggagtg
    25621 aaataggata cgaacaaatt gattaggaaa atcaaatgaa tttatagaaa tcttttagca
    25681 gttatgttgt cctattctag tttcaaaacg ctatagaagc agcattgtgc tagtctagat
    25741 tcagtttact atactaaaac gagtagcttg aaatcaaaaa acccaccctc acaggcaggt
    25801 tttatctgta ttattcagct agattatgct ttaccttctg aaccgaatac gtcgatacgt
    25861 tcttcaaccg atgcttggat agcttttaca ccgtcagcca agaatttacg tgggtcgaag
    25921 agttttttct tgtcgtattc tgcttcgttt gcttcgtagt cacgagcaaa tttacgagtt
    25981 gcgttagcga atgcgatttg gcattctgtg ttaacgttaa ctttggcaac accaagtttg
    26041 atagctgctt ggatttgctc atcaggaata cctgatccac cgtgcaatac gattgggaat
    26101 cctggaagag cttctgtcaa tttttgcaag tggtcaaggt caagaccttc ccagtttact
    26161 gggtaaggac cgtggatgtt accgatacca gctgccaaga agtcgatacc agtttcaacc
    26221 attgctttag cgtcttcgat tggagccaat tcacctttac cgatgattcc atcttcttca
    26281 ccaccgatag taccaacttc agcttctact gagatacctt tagcgtgtgc tttttcaaca
    26341 acttctttag ccaatttaag attttcttca actggaaggt gtgaaccgtc aaacatgatt
    26401 gaagtataac caacttcgat acactcaagt gcatcttcgt agtgaccgtg gtcaaggtgg
    26461 atagctactg gtacagtgat acccattgat tcaacaaggt tagcgatcaa gttgcgagca
    26521 actttgtaac cacccatgta tttagcagca cccattgaag tttggatcaa aactggagct
    26581 tttttagctt ctgctgcgcg caagatagct tgagtccact caaggttgtt tgtgttaaat
    26641 ccaccaactg cataaccgtt gtcacgggct gcttggacaa atttttctgc tgaaacgatt
    26701 gccattttat caggcctcct gtatattttt atgggtcatc ccatttacat tgttcatttt
    26761 atcacttttt gccaaaaaaa tctagttttt cccgcagttt cgattgattt tcttctaact
    26821 ccatctatgt aaaccctttc tctccctagt cttggacgac ttttggaaaa tctataaaga
    26881 aggttaaacg attctcctcc atctcgaaac gataagctaa tttttcatgt tctaatagac
    26941 tcttaaccac aaagagcccc ataccagacc ccttgacctt gcgactggca ttgtcagaaa
    27001 aagactgggc tagtttttct tgttcctctg agctacagct attttcgata aaaagttctc
    27061 cttctctttc tccaattcga actaagccac ctggaacaga gtgcttaatg gcattgctga
    27121 tgagattaga aagaatcaac ttcataactg atgggtttag ataagcctgc tgatgggtca
    27181 aactattgtc tatctggagc tctctttcct tggctagcaa ggcataatct ttgaccagat
    27241 ttttcgtcat ctggaggagg tcaattgttt ccctatcatc tcgcaattcc tgcacagaag
    27301 agagggaaag tatctgcaga acatggtgat tgagttcatc cacaatcccc aaggcaactc
    27361 ccagatactg gtctctatcc ttataacgac cgatattctc tctcatattt tcgattagga
    27421 ttttcaaact agccagcggt gttttcaatt catgagaagc tcctcgtagg aattcgacct
    27481 tcatcttctc cagctggaga atggcttcat tcttttcatt caagtccgca ataacagtca
    27541 agagatgctg gtagaggcta ttgatttgtt ccttgagatt acctatctca tccttagaat
    27601 ccacgcgcaa tcgcacttgg gaatccaggt ccatcatccg acgggtcacc cgcttgattt
    27661 ccaaaatcgg tgcaacaata gtccaagcgt agatgtaggc caccaagagg gaaatcagaa
    27721 aggaggccag caaggtatag ggaagaaact ggagactgat ttgctccgct tccttttgta
    27781 aatccatgga agctagaaac tggagaatca tagtaccacc gtcttgcgtt ttcacctcgc
    27841 gctcctcaat aaagagagag gttgtctggc ggtctgtgtc cagaggaaga ctgtccttga
    27901 cttctaactt gtcctcggtc atctcacctt tgacggttcc cttgatatca ctagtctggg
    27961 aatacaagtc taacacttgc tcgatactct gcctatcttt cccttctagg gactgggcaa
    28021 tggctgttgc cttttgacca atggtttcct gacgatgact cagataagtc gaaggaaaaa
    28081 gaaaataaat agctaaatga aggcagataa ccagaacact aaatatcgag aaggtataga
    28141 taaatatctt tgcaaataaa cctgttcgtt tcattttcgc tccaatttat aaccaacatt
    28201 gcgcacagtg aggatacaat ccaagtctag ctttttccgc aatttctgga tataaacatc
    28261 aataacacgg tcaaagggaa cctcatctgt cgctttccag acggcatcga taatctgaga
    28321 tcgagtcaag gcccggcctt catttttcac tagatagtcc agaatttcca actctttggc
    28381 attgataggc acttcttgac ctgcgaggct tgcactgtag ctttcaaagt ccaccttggt
    28441 atccttgtaa gaaaagattc gtcctgtatc gtagtagcgc ttgaaaatcg cgtccaccct
    28501 cacttttaag agggagaggg agaaaggttt ttccagatag ccatctgcca aagaagcaaa
    28561 ggcactcatc ttgtattcct catcctgaaa agctgtcaac atcaagacag gaacctgact
    28621 ggttttacga atctcagcta ggacttctaa gccgttaagc ttgggcatct ggatatccag
    28681 taaaaccaag gccacctcat agctagaaaa ttgctccaga gcttcctgac cgtccgctgc
    28741 ctcaatagtt tcatagccac aatccgtcaa ataatcactg accccctcac ggatcatctc
    28801 ttcatcttct acaattaaaa ttttcatact ttaactgctc tctatttttt atttttctta
    28861 gaataaatac ctactctatt ttctattata gtctcttgct ggccttttgt ctgtaagcaa
    28921 ctgaccacta gataaaacgt tgtgaaattc ctttctcata aattccataa ctttagtata
    28981 ttatatttaa gcactaaagt acaaagaaag caactgaaag caatgatttt caccactgct
    29041 ttcggattta ttttgaattg ttaaatagcc attcctatcc actattcttg aatagaaaca
    29101 caagatgcaa tctttattcc agactcattt tttcaaattt attcaccatc cagcaagagc
    29161 tcttttggtt gttttctaag gagattgctt gaagcaagcg ccataacgag aaccactaga
    29221 accaaggcaa ggacaaaaat gatgataaag tctgatgtct gaatggaaat gtctaggctc
    29281 gacaaggtct tgctaaagcc atctacttct gcaccgccac caaggttaga ggcttgagcc
    29341 gccttactag cctgtttggc aacacctgaa gtcacattgg caaggacagt gtttccaatt
    29401 gcacgggcag tgtaattagc taggaagtaa gcagaaacta gagcagggat agcaatcaag
    29461 atagattcgg tgatgaattg acccaagata cttgcctgct tgaggccgat agagaggaga
    29521 attcccactt ccttgcgacg ggcgttgatc caaaggctga gcaagagggc aaggaggaga
    29581 actgagaagc tcaagctacc ccagaagagg aggttggcca tcttgtacat accagagata
    29641 gattgctcaa gagctgggta gttagaggag ctcttgacga gtgtgtagct cttccagttg
    29701 ataccactga tgccattcaa ctctttcata acatcatcca agttcttgtc tgctgttaca
    29761 aagaaggttg cgtccccata aatggctgtg tcttctgtgt atccataaag ttttgcagca
    29821 gtgtgaatgt ctgtaatagc tgtgttttcg taaagttctt gtgagtaggt tactgctgac
    29881 ttattatgac catcaaagag tcccttgatt gtcacttcaa ctgtttcctt ggctcctttt
    29941 tcattatctg catcgtagat attagagtcc agtttaacct tgtcccctac tttccagccg
    30001 tgtttggctg ccaagtcctt gtgcaagagg attttatcct tgtcgtcgtt ggttaagtgc
    30061 tctccttcga ctagtttata agaaccagag acaaacttgt cttctttaga ggagtcattg
    30121 acacctgtaa tcatcaagct acttccaaaa cgtttggcac gatcagcagt gagattcttc
    30181 ttggtttctg gcgtttcaat caggtcatat ccagtcaaat ctccgatagc gttgatacgt
    30241 ttgacataag actcaatggc cttgttttcg gtgatttttt tgatgtcttc acccttgata
    30301 ttcccagcac cacgaggcgt tccttggttg acgcgacgat tgatttgcat ggagaagcta
    30361 ttggtgatat ttttaaaggt ctcctgagaa gccttggcag tagctccctt gattgacaag
    30421 ccgaccaaac tcaagctcgc catgaggaga ataatcagga agatgacaat cgatttgaaa
    30481 aacttccttg taacataagc aaatgcgttg tgtaacatag attccctttc tagattttgt
    30541 tttaatcatt ctatcaaaat aagctcaaat tatttactag tattgcgcgt ttcagtcagt
    30601 ttcttatcct ttaattcaag tgtaatatct gacgcttgtg ccacttcttt actgtgagtt
    30661 acgacaatca cacatttacc tgttttctgg gcaagtgatt tgagtagttc gacaatatct
    30721 ccagcagttt taggatccag atttcctgtt ggctcatcag ctagaataac tggagcttct
    30781 gagaccaaac tgcgagcaat ggcaacacgt tgctgttgac cacctgataa ctggagaaca
    30841 ttccgcttga tctggctttc atccaaacca agctcaagaa gtgtattctt gcttgccttt
    30901 ttgttgacca atcggatatt ttccagcgga gaaagataat ctatcaagtt ataattttga
    30961 aagaccaggg aaatatggtg catgcgatgg taagaatagc ccttcttacg aatatcctct
    31021 ccttgaaaaa ggatagaacc ttcaacagga ctatctagac cagcaagtag ggacaagagt
    31081 gtggattttc ctgctcctga ctccccaata atactgtaaa attttccggg ttcaaaatta
    31141 taattgatct gatataggac tgcttcagca gtattcttat aacggtaggt aacatcttgt
    31201 aattgtaata aagtcatgat ttctccttct taactaatag atgataaaat ttctttcggt
    31261 gattttctaa ataagaatag gaaacaaagg gctacagata agcaactaag cagaactaga
    31321 aaaacatagg attctgcaaa agataagatg ctagttgata aactgcttgc tttggctagt
    31381 gtatcttgta agcttgcctg atctccactt gctagtagag tttggagtag gtaagttgtg
    31441 attgcgtttc ctgcaacaaa tgctggaagc aaagctccaa gagataccaa aactacctct
    31501 aaacagaatt gtaggaagat cgagctcttg ccttttccaa gtgcaagtaa aatccccact
    31561 tcatagaccc gttctctcaa ccagagagac aaaaccagaa ttaaggctcc agctcctgct
    31621 atcaacatcc cataaaggaa gatggtcagg aaggtttgga aagttgcaac tgagtctttg
    31681 atttgttcaa aagccttgtt ttccttttcg acttggtagc cttgattttc caaggccaag
    31741 ttttctacct gcttcatgag tccgtccatt tccttaggat tttctacata gaagcgtgct
    31801 gcactgactt gagcttcact attgcccaaa agggtttggc tactttcata gtctgtaaag
    31861 acttgatttt cactgaagtc agaagacaag cctgtgaatt tctcttgttt tttaccagaa
    31921 aagatgccga taatctcaaa ctctactgtt tgtccttttc cagattcaga ctgaccagca
    31981 tccaagccaa tcttgtcatg aagcgaaaga ccgttcttct tagccaattc ttcgtggata
    32041 aggattttct tggaatcccc tttttgaagg tgtcgccctt cttttagatt gaaagccgaa
    32101 ctggtaaagg ttacatcctt ggatgaatcc tcaagagccg ttaagctaac caagttattg
    32161 tctgcagctg ataaatcatc acgctccacg ctctgctcgc cagtcactgc ttccttgtct
    32221 tttagttttg cgaccgtctc aagttcagga gagacatttt ccagcccctt aatcttgctt
    32281 acagatgcta ggtctgacaa cttgaatgtc tgaccattct ctatcttctt aatagaaaaa
    32341 gatgtattga gtgatttata aagattgctt tctactgttt tgttggactt catcagagtc
    32401 aaacaggctg aaattccggc caataagacc aataaaatca gaaataaaat aaaacttctc
    32461 agtcgctttc tgctgacata agcccaagat ctttggattg gattcatttg tcacctccat
    32521 atttgtaaga ctattataaa acccaaatat gaaatgttta tgaaatacga aaaaaaatat
    32581 cgagtagggg ataatctcta gcccctctca caccaccata cgtgccgttc ggcatacggc
    32641 ggttcaacta acttttaacg catgtcgttc aaggtaataa tccaaacacg aaaccagtcc
    32701 acgtttttca aggactggtt ttgatatggc acgtttaagt accgacttct gagctactat
    32761 agtagattga aactagaata gtacatctct tcttctaaaa tattgttaga aatcgatttg
    32821 acttccctga tcgattcgtc ctattcttat ttcattttac tataattgat agtggtcgcc
    32881 ccagccagat accttatctg ctatccattt aggaacccct aacttaagca atccccataa
    32941 tcgtctcgat ttcttcttcc attgcttcca gataatcact cgtaggcgag tacgcaagcg
    33001 ctcatctatg ctagtgacta tacttttcat atttataatt cattcctttc gtttcactca
    33061 aggcacaaca cagaatgaaa aagtgttgtg atctttattt tgttttataa taatagtgag
    33121 aaagcctatc actactacaa atcacgggga ggtgaataag tgagtggtac agccactacc
    33181 tcgcatattt tgtcacatca tttaacggta cataataagt tgtaccatct gaataagttg
    33241 ctacaatatc atttgcatgc tctccttcac ctttagcaaa ggttggagct cctgctggat
    33301 gatttttatt tgcctctttc aatttttcaa taatggcatt tttttctgta tcttttatag
    33361 tatcaggatt tttcactaag attttgtctg gatatgtcgg tttagcagaa acaattttta
    33421 ctgttatttc ttttttattc gaagcacttg tccagtttcc agcattatct ttagtattta
    33481 attttacagt aattcctgaa ctaggaactt cagtagcagg ttgattatca acattattca
    33541 actttaattt caaaagagct gttgcatcag acgttttatc aatcgttgta tataatgata
    33601 aattgttatt ataaccaatt tcttcatatt tagctgtttg tgagctactt gaaacagaac
    33661 tgaaattatg cccactacct ccctgattat cttcaatgct tacgtctaaa tgaacttccc
    33721 cactattatt tggcttagca acaactgtta tagtaaaata acataaaatt tgcataaata
    33781 gattagggaa atcaaagcaa cttctaggaa tgttttagca gtcacagtgt actttcccag
    33841 catcaagcca ctataactct gcacataaaa atggagaaga tggccatcct cttctccaaa
    33901 tattaacttc tttacaaacc aactatagtt gacaaagaac ctaaaatcaa ttgataacac
    33961 aaggtcaggt cggtcaactc tttcaactga agccctgtca actcttccca tttatcaatc
    34021 ttgtattgga gagaattgcg gtgcagatag agttgctggg ctgttttagt gagaacagca
    34081 ctattttccc aaagagagag aatgatttcc tgaatctgat cttgatccaa aatcatctgg
    34141 tgtagacatt ccttgattgg cttcaagtcc acgagtcttt ctcccatact ccaaagatag
    34201 agttgagaaa aagtatgaac accttggtga ccctgacgcc accatgtctt gaacaaatcc
    34261 cgctcagctt tgattaagtc tgatagggct tgatgtcccg tctgagacca aacctgaccc
    34321 aacatgatag aaagacgaag tccaaagtca tactcaaccg cttcaatcgt atcacttaaa
    34381 atatctctta cagaagtgta tttgtcttgt tgaagcacga aaacataatc ctgagctccg
    34441 acctgtagca ctgtctgaca attcggaaaa agagtccgca tcatatctag ccaagaagcc
    34501 agattttcct gctgaaaata agaaagatgg caataaacca actgaatctt tttaaaaact
    34561 tgcggtgcct gtcccttgcc ctcaaccaga taggaatacc aagggtttag cgaacgagcc
    34621 tgctcctgct gggtcaaaag ggcaaccaac tgcttttcac gctcgctgag cccagcttcc
    34681 tccagcaaaa tccactgctg agaagctaaa gggagcgtga gatagccctc tttctctact
    34741 ggttggtctg aaatccgagc ctcaggaaac cagtcttgta gttcttttgc cctcatgttc
    34801 tagccctcca ctttttggat gcaccatgaa accaaactct caagacgttc cagattctca
    34861 gtcatatgga gatagcccat aaccgcttca aatcccgtgg acatacgata agtcacgaca
    34921 tctgcatttt tagcctttgt gtggctattg gtattgcggc cacgtttgta gatttcttct
    34981 tctttttccg ttaggacctg ctcctccaac atgagagcaa tcaggcgagc ctgagccttg
    35041 gctgacacgt acttagttgc ttcttgatgg agtttattgg gtttggtcat acctttgagg
    35101 atgaggtgac ggcgaatata catagaatac accgcatccc cctcaaaggc tagcgcaatc
    35161 ccgttaatga gattgacatc aatcacgtgt ccacctcact ccatccttgg tatcaaggag
    35221 cttaattcct tgagtaacca attggtcacg gatttggtct gctgtctcaa agtctcgatt
    35281 ggcacgcgcc tcttggcgtt tttgaatcaa gtcttcaatc tctgcatcca aaacttcctc
    35341 aacaaagaca attccaaaaa tttctaacat atctgcaaga gcttgcttga cacttgcatc
    35401 atagttccct gagttgatcc atttggccat ttcaaagaca actgtgatac cgttggcagc
    35461 attaaaatct tcatccatag ctgctacaaa cttatcttta aagttttgta actcttgggc
    35521 atccacgttt cctgtaaatg gttgttcgta agtattcttc agatacttga gattggtctc
    35581 ggcatcgcga actgcctttt ccgtgaagtt gataggctta cggtagtgct gggtcgcaaa
    35641 gaagaaacga agtacttgcc catcaagagt tttaagggca tcgtgtaccg taatgaagtt
    35701 acccaaggac ttagacattt tgacattgtc gatattgaca aagccattgt gcatccagta
    35761 gttagcaaaa gccttgcctg ttttagcttc agattgggca atttcattgg tgtggtgtgg
    35821 aaactctagg tcagctccac caccgtggat atcaatggta tcacctaaaa tctctgtcga
    35881 catgactgaa cactcaatat gccaacccgg acgtccaggt ccccaaggac tatcccaaga
    35941 aatctcacct ggtttggaag atttccataa agcaaaatct acaggatttt ccttacgagc
    36001 cgtttcttca tcggtacgac ctgaagcacc tagatccaaa tcttccaagg ttttattagc
    36061 caatttagca tagttgtggg atttttctac acggaaatag acatcccctt gactctcata
    36121 ggcaaagcct ctctcgatca agtcttccac aaaacggatg atgtctgcca taaactccac
    36181 tacacgcgga tggcgagtcg caggtttcac gcctaaggcc gtcacatcct cacgaaaggc
    36241 agcgatgtac ttatccgcaa cctcctgagg cgtgatacct tcttccctgg cacggttgat
    36301 aatcttatca tccacatctg taaaattgga aatataggca accttatacc cacggtactc
    36361 aaaatagcga cgaatcgtat caaaagctac cgtcgaacgg gcgtttccca cgtggatata
    36421 gttgtacacc gttggcccac aaacatacat cttgatcttg ccgtcctcaa tcgggacaaa
    36481 ttctcgcaaa tcacgagaca tggtgtcata gattttaatc ataaatcata atcaggaaag
    36541 ctgaaatcca agaacaatta gtttcatcac taaaagttca agtaaatttc agtccgaata
    36601 tctctacact tcggaatccc ttgctccttt ctcattcaga taaaccacct gagtctgttt
    36661 gacaaagcca attttttcat acaaacgttt ggcacctaca ttgctatctt ccactgcaat
    36721 ctgaaattcc ttgtcatttt gctcaattag ttggttgacg agggattttg ctaagtagct
    36781 tccatagcct tttccacgtt caggttccaa tattgctaaa ccatagaggt aattcgtatt
    36841 agtcgataaa tcaaccgtac aagttccaat aacctgacca gcttttaata aaatatatag
    36901 tcggctttct ggatctttca gagcttcagc gacatatcta tccacaactt ctctcgattc
    36961 atgttcctct gaaaatgcct gaaattttaa ttgactaatt tgatcctgat acgaactatc
    37021 tgctaacaaa atttcaagat gggaaacatt tgctaacgga taaggtcttc tatccttacc
    37081 taaccaagtt tctgtctctt catcctcgat tagtccccag ttactggcaa agtcaggatg
    37141 attctctaaa aaaatacgtt ctgtctgaaa agtgactgat cgaatgggga aagaagctgt
    37201 ttctctctca aaactagtaa acaatgcacg cgcaatcccc tgacggcgat gacctggatg
    37261 aaccagtatc gtcacttcta catcttggtc atctgcatag acagttaata aaccaacaag
    37321 ttcgcctttt tcataataaa ggaaaaaggc gggcatgttt gggtcaaaat taagcatgtt
    37381 agagagatag ggatcgcgat aggtaccgtc atagttttgg caacagttaa ttactttttt
    37441 cgcctcagat agctcctctt ggcttaactt gtttcttgct tgaatcatat aggtatcctc
    37501 tacaaaccag acgatctgtg actggcatct ttagcctgct cgagtttatt gacataatac
    37561 tcccgttttt cttcgacttc gtgaataaca ggctcatctt tcttaccatg aagacggaca
    37621 atcttggccg gaataccgac aaccgtcaca tcactaggta catctgctac gacaactgct
    37681 gcagcaccga ccttggcatt ttcaccaatt tccacaggcc cgataacttg ggcatgggct
    37741 gatatgaggg ctccctttcg tacagtcgga tggcgtttgc cacagtcttt ccctgttccc
    37801 ccgagagtca ctccgtgata gagaagaacg cctttttcaa caatcgctgt ctctccaatc
    37861 accagaccag aaccatggtc aataaagaca cctgaatcaa tctgggctcc tggatgaatc
    37921 tcaatctgag tccaaaagcg ccaaaactga ctgtgcatac gagctaagag tttgaagtcg
    37981 tacttccaga gaaaatgcga gagacggtgg gccgccaagg ccttgacacc tggataagtc
    38041 agcaaaacct ccaaagtggt gcgggccgct ggatcatttt cttttacgat atcaatggtt
    38101 tcgcgccacc accccataca tttctccttt tcttactctg aatcttttgg tgtttctgta
    38161 aattctttct taggtttgtg atccttgtga tgacgtgggc ggtgagggcg ctcagacttt
    38221 tcaccttttt catcatgctc aggttttggc ggacgaggta gaagagcctt catagaggca
    38281 tcgatacggc ctttttcatc aatcttgata accttaacat caacttcatc cccgatttct
    38341 accaaatcct ctacacgatt ggtacgagtc caagccatct cagagatatg aacaagggca
    38401 tctgtcttat caaagaggtt aacaaaggca ccaaatttct cgatacgaac gactttagca
    38461 cggtaaactt catccacttt ggcttcacga accaaaccag caataatttc tttggcacgg
    38521 ttaatagcat cttggtcact agagtagata gacacatttc cttcttcgtc tatatcaatc
    38581 ttaacacctg tttcagcgat aatcttgtcg atggtttctc cacccttacc gatgacaatc
    38641 ttaatcttgt ctacatcaat cttgatcgta tcaattttcg gagcagttgg agccaattct
    38701 agacgaactt ctggaatggt tgcttcaatg acatcaagga tttcaaaacg cgctttcttg
    38761 gcttgagcaa gagcctccgt caagatttct gcagtaatcc cttgaatctt gatatccatt
    38821 tgaagggctg taatcccatc acgagtacct gcaaccttga agtccatatc tccaaagtga
    38881 tcttccaaac cttggatatc tgtcaatact gtgtagttat ttccatctga gataagtccc
    38941 atagcaatac cagctactgg cgccttgatt ggcacaccac cagccataag ggcaagagtt
    39001 cccgcacaga tagaagcttg agatgaagaa ccgtttgatt ccaaaacttc tgctactaga
    39061 cggatagcgt atgggaattc ttccaagctt ggcaagactt gagcaagagc acgctcacca
    39121 agggcaccgt gaccgatttc acgacgacct ggcgcaccgt aacgacctgt ttcccctaca
    39181 gaatattgag ggaagttata gtggtgcata aagcgtttct tgtactctgg atccaaacca
    39241 tcaatgattt gagtttctcc catcggagcc aaggtcaaga ctgaaagagc ttgagtttgc
    39301 ccacgagtaa agagacctga accatgtaca cgaggaagga agtcgacaac cgcatccaaa
    39361 ggacggattt catcgacctt acgaccatca ggacgcacct tgtcttctgt aattaaacgt
    39421 cgcacttctg cgtgttccat ttgttccaag atttcagcca catcacgcat aatacggtca
    39481 aattcttcgt ggtccgcata tttttcttcg taaacggcag tcacttggtc tttcactact
    39541 tgagtcgcag cttcacgggc caatttctct tctacttgaa ctgccttttg gaggtcactg
    39601 ttgtaggctg caatgatttc agcttgcaat tcagcatcca cgtgaagcaa ttccacttct
    39661 gctttttctt taccgacagc agcaacgatt tcttcttgga aggcaatcaa ttctttgaca
    39721 gcttcgtgcc ctttaaggag cgcttccaac atgatttctt ctgacaattc tttggcacca
    39781 gactctacca tgttgatagc gtgcttggtt ccagctactg tcaattcaag aagagattgc
    39841 tctgcttgtt cttgacttgg gttgatgatg atttggccat ctacatatcc cacttgtacc
    39901 ccagcaattg gtccgtcaaa tggaatatct gaaatagaca gtgccaaaga tgaaccaaac
    39961 atagcagcca ttggtgcaga tgcattttca tcataagaaa gcactgtatt gatgacttgg
    40021 acttcattac ggaaaccttc cgcaaacata ggacgaatcg gacggtcaat caaacgcgct
    40081 gtcaaggtcg catctgttga aggacgtcct tcacgtttca taaagccacc aggaaacttc
    40141 ccagccgcat acattttttc ttcgtagttg acttggaggg ggaagaaatc cccagttgcc
    40201 attttcttag acataacggc agcagtcaag acagttgact caccgtaacg tacgacaaca
    40261 gagccatttg cttgcttagc aacctgacca gtctctacaa ttaactcacg acccgcaaaa
    40321 gtcgtttgaa acacttgttt tgccatttta atcccctttg gattgatgaa attatacgcc
    40381 ttgcctacaa agatcaagat accaaggacg tcaaaagcaa agtaaaaata ggaaactgac
    40441 gaagtcttcg atgaagacaa aacagtttat cttttttaca cagcttttcg gccgtgttca
    40501 attacacaag atattttgga cggttcggct tgccgaacat ttctgtagaa aaataggaag
    40561 gtgacgtcgc actcgacgag tgctaggaag cttatctttt ttcctaagaa atgagaccaa
    40621 aattcaatta ctcaagatgc taagccgtca agcaactcaa aggaaaatag gaaatcgaac
    40681 gacggagcga ctgctcctag gcagatttat ctttttccac agagttgtag gcgtgttcag
    40741 ttttcaagat acatcattag aaagatttaa tattaaagta tctaaacctt tcacgccaat
    40801 cgctatcggg cgattagcta aatgctttac taactctttc gtcaaataac atcgatttga
    40861 ctcactcgtg tcgttaaatc ttacagttta aatgcattgt attatttaat accttcatct
    40921 ttgtatcaag tacgtacaga atttatttta tcatattttt cttaaaaagt gaggtcttta
    40981 ccattaaaaa ggaaccattc ccctcacctg agaagaatgg tttgctttta ttatcctaga
    41041 gactggtgat taaacaaggc atgggttgct tgatggatgt attttgctgt atcagcatta
    41101 ttcatcgtat agagatgcac accggcaaca tcctgagtta ccaagtccac gatttggtcc
    41161 actgcatagg caagtcctgc tgctctgagc gactcagggt catgctcata cttgtctaag
    41221 atggctttaa atttgcgtgg aagatggata ttctcacaag tcttcaagag tcggagagcc
    41281 tgatttcgat tcagaattgg cataattcct gcatgaatgg gaacatcaat cccagccaag
    41341 atgcacttgt cctgaaaatc atagaagcgc tcattgtcaa agaagagctg agttacgagg
    41401 ctcgaacagc ctgcatccac tttcttctta agattttgaa tatctgaaat ctgatttggc
    41461 gaatctggat gcccttctgg atagcaagct ccaataatat caaagtgagg ggtttgttcc
    41521 ttgataaact caatcaagtc ggttgcatag cggaaatcct tttgtggttc cacgtctgga
    41581 ataatatccc cacgaagagc caagattttc tgcaccccaa ctttgtccaa gtcagcaata
    41641 gtttcagcaa ccttgtcctt agttagataa atagctggca agtgggcaat ggtcggaatc
    41701 gccaaatcat tttggataaa gtcagccaaa cgaaccgtcg tttccttgat attaaattta
    41761 ttattgctgg cagttacact gataaaatgg ggagccaact cctgcatatc ctgcaaggct
    41821 gaaataatgt taccattacc cacggctggg tttggaggga acacttcaaa tgagagtgac
    41881 ggtgtttggc gtgacatatg taataacctt ttctagttga tttctttttg aacaaccact
    41941 gtatggagag aaatccaatc ttacaatttc tcacgcgcag ctttagctgc ttcaacaagg
    42001 cggatcaagc tttcttttgt ttctgggata ccacgtgttt tcaaaccaca gtcagggttg
    42061 atccaaactt tcttgcttgg cactttagca aggatggctt cgattgtgtt gtcgatttcg
    42121 ccttcatttg gtacacgagg tgagtggata tcgtaaaccc caggtcccac ttctgtttgg
    42181 aagtttttcg ctttgagttc gtccaagatt tcaaggtttg aacggctggc ttcaaaggaa
    42241 ataacgtctg catccatgtt atcgatagct gggatgatat ctgtaaattc tgagtaacac
    42301 atgtgagtgt ggatttgtgt gtctgacgct actgttgagt gtaccaagcg gaaggcagga
    42361 attgcccagt caaggtaatc ttcgtaccag tcactacgac ggagtggcaa tttttcacga
    42421 agagcagcct catcaatttg gatgattttc acaccagcag cttcaaggtc aagcacttca
    42481 tccttgatag caagggcgat ttgaagagta gaatccttga tagagatgtc ttcacgtggg
    42541 aatgaccagt taaggatggt aacaggtcca gtcaacatac ctttaacagg tttgtttgta
    42601 cgactttgtg catagctaga ccatttaaca gtgatagggt taagacgagt gacatcaccc
    42661 cagatgattg gtggttttac cccacgcata ccgtatgatt gtacccatcc atttttagag
    42721 aagaggtatc ctgacaagtt ttgaccgaag tactcaacca tgtcattacg ctcaaattca
    42781 ccgtgaacaa ggacatcaaa gtcaatatct tcttgccact tgatccattc gtcaatcgtt
    42841 tcagcaagga aagcatcgta ctctttttga gacaattcac ctttacggta agccaaacgt
    42901 ttggcacgaa cttcttttgt ttgagggaat gaaccaatcg ttgttgttgg aagagctgga
    42961 agtttgaaag cttcttcttg gatagcttca cgttctgcaa aggctggcaa acgagtgtag
    43021 tctgcgtctg tcaagccagc gatacgcgca cgaagttcag cattttcacc aacacgctca
    43081 gtcgcaaaga gttctttgtt ggctgcaaga gcttctgaac cttgaccatt gcggatagca
    43141 tccaagtcac ggatttcatc caatttttca actgcaaagg caaagtggtt caagagtgct
    43201 ggttcaaatt cttcattagc agttgtaaat ggcacatgaa gaagtgagca agagcttgtc
    43261 aaaacgatgt tttcagctgg gatttgctca agaacagcca agctcttttc gtagttgttg
    43321 cgccatatgt ttttaccatt gacaatacct acatagagag tcttgtcagc tgggaagcca
    43381 cctttaacta gttcaagagt tttcttacct tcaacaaagt caagaccgat agcatctact
    43441 ggtaagttta caaggtcagc gtatacgtca cgaacatcac cgaaataagt ttgaagcaag
    43501 acttcaagac cttttttgtc agccaagagt ttgttgtaaa ggttcaagaa gagagctttt
    43561 tcttcagctg tcaagtcttt tacaagagcc gcttcatcca attggatgcg agtcgcacca
    43621 agttcagcca atttagcaaa aacttcttgg taagcagcca ctaagctatc tacgaagtcg
    43681 tctgctttca cgccttcttc aaagtctgac aattgaagga aagtgaaggg acctacaaga
    43741 acaggacgag tgttcaatcc aagttctttg gcttcttgga actcatcgaa aatcttgtga
    43801 ccagccaatt ttacttgagt gtctttttca aatttaggaa cgatgtagtg gtagttagtg
    43861 ttgaaccatt tcttcattgg aagggcgcga acgtcccctt tttctccctg gtaaccacgt
    43921 cccaaagcga agtagcgctc aaggtcagac aagtccaagt tttgaacgga tgcaggcacc
    43981 acgttgaaaa ggaaagccgc atctaggaag ttatcatagt gagaaaagtc atttgatgga
    44041 atttcagtga tgcctttttc tttgacaatg ttccagtgtt tagcacgcaa gtcttttgct
    44101 gctgctaaaa gttcttcttc tgagatttct tttctaaagt atttttcagt tgtaaatttt
    44161 aattcacgga attcgcccaa acgagggaaa ccgatgattg tagttgacat gatgtgtcct
    44221 ccaaaatttg ttgttgaaac tatcttaaca gaaaagaaag cgtctgtata attgtaaaaa
    44281 attagggttt gatatagttt gaaactatat atctgtttcg gacaaaagaa aaagacttga
    44341 agcaaacgtc tcaaatcctt tgtaattctt actttacagc tatattccaa ttagaatact
    44401 aaaacatgtt attagtaatt cttataagtg actatgacct gttattagaa aagactataa
    44461 ctgattctag tcaacttttt ccctgttcaa gtgggacgat tgctagtgtc tttcctaaac
    44521 tggctaggac ttttaagact gtatccaact gaggactagt ctttcctgtc tccatcctag
    44581 ctatgacagg ctggcttatt ccactgactt cttccagctt tttctgactg attccttgtt
    44641 catacctagc ctcaatcaac tcgctcatga tagccactcg catatcactt tcaaggattt
    44701 cctccttgct aaagagctca gatggacatc cttccaatta ctcccaatag cactattctt
    44761 catcacttaa ccctcttttt ttacgtctat gtatttttaa aaaaatgagc gaattatgat
    44821 tcgatagatt gaccagtggg tttaaagttg gtgctagcct atttcttaag cgattttcct
    44881 tttctaggat aaagcagatc ctgcttgctt aaccccaatt ttccacgatg aatccaatag
    44941 taaatggttg aaattcccac gttaacccct ttagccatca ccatcatttc aggcgaaaat
    45001 ttttggttat gtatagtgga gaatcttttc ctttagtttc ttaagactgt tgagcgtagt
    45061 cggcagaata aatctctttg aagcgccctt ttccaagaca ttgtcggact gtcccacgct
    45121 tgatttcagt gtggatagtt tgaggagctt ttccaagtag agaggcaatt tctctatttg
    45181 attttccttc ttttttccat cgttcgatta agcgacggct atcgattgtc aaatgtttgc
    45241 cttttgtagt ataattgtct tgcatttctg tgccttttaa tcatttcaat cttaaattgg
    45301 acttttttta cttgggttgt acttaatcta taaggaagac aagaaaaaga atatcaatca
    45361 agtaaagtca caaagtcaca ttagctccga gcaaccattg caaattgagg tactcacaca
    45421 atgattaaaa catttctctc tgccctttcg gtcattctct ttgttatccc tatcatagct
    45481 tattcttttt ttccatcttc taatcttaat atttggctat ctaccagacc tatcttggca
    45541 cagatttatg ccttcccctt agctactgca actatggctt ctattttaag tttcgtattt
    45601 ttttccctat ctttttacaa gaaaaataaa caaatacggt tttactctgg cattttgctc
    45661 ttactatcgc tcatattact attatttgga acagataaaa ccctttcttc tgcaccaaat
    45721 aaaactaaaa ccttaaaatt agtaacttgg aacgtcgcta atcaaataga agcacaacat
    45781 attgagcgaa tttttagcca ttttgatgcc gatatggcta tattccctga actagctacc
    45841 aatatcagag gtgagcaaga aaaccagaga atcaaactat tgtttcatca agttggactt
    45901 tctatggcca actatgatat tttcacttct ccacctacca atagtggaat agctcctgtg
    45961 actgtgattg tgattgtcaa gaaaagttat ggtttctata cagaagctaa aacttttcat
    46021 acaacacggt tcgggacaat tgtattacat tcgagaaaac aaaatatacc agatatcatt
    46081 gccttgcata ctgctcctcc tctgccaggt ttaatggaaa tctggaagca agacttaaac
    46141 atcattcata atcaattggc ttcaaaatat ccaaaggcta ttattgcagg tgattttaat
    46201 gcaactatgc gtcatggagc acttgcaaaa ataagctctc atagggacgc attgaatgca
    46261 cttccacctt ttgaaagagg aacttggaat agccaaagtc caaaactttt taatgcaacg
    46321 atagatcata tcttattgcc taaaaaccac tactatgtta gagacttaga cattgtaagt
    46381 tttcaaaact ctgatcatag atgtattttt acagaaatca cattttaatt attttatata
    46441 aaatcacccc tctagtgttc ataaactaga gggggaattt gtatcctact atcgtttaac
    46501 gcacttctgc attcactttt tcttcgagcg atgcttggat tttttccata tagcgtgcga
    46561 cttcttcgtc cgttaagcta tcttctggat tttggaaggt caagctataa gccatggact
    46621 tcataccaag tcccaatttc tcacctgaga agacgtcaaa gagtttgata tctgtcaaac
    46681 gtttcacgcc ggcagcttgg atagcatcta caacttcttg atgagtcact tctgccttga
    46741 ggagaagggc aacgtcacgg ctgactgctg ggaatttggt gatttctaca aatggagtcg
    46801 ctggctgaag cgcagcttcg atagctgaaa ggttaagctc agctacatac gtttctggaa
    46861 tatcgtaagc cttggcagtg actggatgca cttggccaag gaaaccaaga acttggtcac
    46921 cgagtgaaat cacggctgta cgacctggat gaaggctagc gatttcagat gttgctgtat
    46981 aggttacttg gagtcccaaa cgagtaaata gggcttcaag gattccctta gcatagaaga
    47041 aatcaactgg aactgctgct gtttggaaat ctttttcagc aaccaagcct gtcaaggcaa
    47101 aggcaaagct gttgatctca tttggaagtt cttcttttgg attacctgtt tgttcaaaga
    47161 cttttccaat ctcataaagg gccaagtttt tattcttacg agccacgttg taggcaacgg
    47221 tatcaaggat ccctgaaatc atattttgac ggaggactga acgatccaca gtcattggcc
    47281 acatgagttc agtaaggtta cttggttgag ctgtgaactc aactgctttt tcaggagttg
    47341 tcagagcata ggtgataatt tctgtcaaac ctgctccttc agcaatggta cgaacttgac
    47401 ggcggagttt ttgtgtcaca gtcaattcac cagctgtacc atcgtctttt ggaaggctgg
    47461 ttggcaagcg gtcatatcca tagatacgag cgatttcttc aaagagatca gcttcgattg
    47521 tgatatccca acgacgacgt gggactctga ctgtaaagct gtctgcattt ccagaaagac
    47581 caaagccaag acgacggaag acgtcttcta catcagcata agacagctca gttccgagga
    47641 cacggttaac atcagcaagg gttgaagaaa cttctacatc tgaagtatca agctcacccg
    47701 ctgaaacgat gcccttacgc accgtcgcac ctgcaagttc cgcaatcagg ctagctgccg
    47761 catcaagggc ttcattaact gttgccacat taattccttt ttcaaagcga gaagatgact
    47821 cagaacgaag gttcaggcga ccacttgtct tacggataga tttgccattg aaaacagcag
    47881 cttcaaggac aacacgacta gatttttcag agatttctgt tgcttgacca cccatgacac
    47941 ctgcaagggc tactggcttg tctgcgacag tgatgactag gtcattcacg tccaagtcac
    48001 gttcttcacc gtccaaggta accaattttt caccagcacg cgcttcacgc acacggatgt
    48061 cagtcccttc aaatgtgtcc aagtcaaaag catgcatagg ttgaccaaag tagagcagga
    48121 tgtagtttgt cacgtctaca acgttattga tgggacggat gccttcgttc atgagaaggt
    48181 tttgcaacca ttgtggactt ggtgcgatgg tcacattgtc caagatacgg gccgcatagt
    48241 aaggtgcctt gtctgtctca atgcccacag aaagggcatc ggctgcaact tggtctgttt
    48301 ctgttaaagt aaattctttg aagttgactg ccttgtcata tatggctgct acttcgtgcg
    48361 caaccccaca catagaaagg gcatctgcac ggtttggtgt gatagacagt tcgatgattt
    48421 catcatccaa gtctaggtaa gaaaagactt cctcacctgg cacggcatct tcaggcaaga
    48481 tttggatgcc atctgcgaat tccttaggca caactgagtc agaaattccc aattcaccaa
    48541 gtgaacagat cattccaagt gactccaaac cacggatttt tccttttttg attttgtagt
    48601 tatcagcgat acgagctcct ggaagagcca ccatgacctt gatcccagca cgcacatttg
    48661 gggcaccaca aacgatctga cgctcttctt cttcgccaac gttaatctga caaacatgga
    48721 ggtgagtctc tggcacatct tcgcaagaca agacctcacc gacgacaatt tttgagagac
    48781 cagcagctgg tgattcgaca ccctctacct cgatccctgt agttgacatt ttttcagcca
    48841 actcttgtga tggcacatca atgtccacca attcttttaa ccatttataa gatacaagca
    48901 taatttagtt ctccagaatg accattgcca cactggttct tttcctttcc tatcatttca
    48961 atagaagaat cctcttctta ccttaatttc tttctcagta accaatccgt atctactttt
    49021 tgaccaacca taaaatgatg ttggctaaat ttttcaaaac catatcggtt ataaaacgct
    49081 tgagcttttg tattatgctc ccaaacacct aaccaagccc aagaaaaact attttttgta
    49141 gcaagttcaa gtgcgaattc aaacagttgc ttacctagtc caaatccttg gaatttttgt
    49201 agcacataga ggcgttgaat ttcaaaagcg tcctctaatt ctctctcagt ttgagcactt
    49261 ccccagttga ctttgagaaa accagctatc tcctcctcat gcataatgaa ataggtttca
    49321 gagtcaggat ttcccaactc agttgacaaa gttttcagac tataagcctc ttcaaagtat
    49381 tcctgtaact gctcttccgt attatcatac gcaaaggttt gtttggcaat tttagccaac
    49441 acctcaacat ctgccatttc tacttttcta atcattattt aaactgttct gagaagcgga
    49501 catctccttg gtagaatcca cggatatcgt tgattccata acggagcata gctacacgct
    49561 cttgtccaag accaaaggca aagccagagt atacagtcgc atcgatacca ctcatttcaa
    49621 ggacacgtgg gtgaaccata ccggccccca taatttcgat ccaacctgtt ttcttacata
    49681 cgttacagcc ttctccacca catttgaagc aagaaacatc cacctcaaca gatggctctg
    49741 tgaatggaaa gtaagatgga cgcaaacgaa tttgacgctc ttcaccaaac attttttgga
    49801 caatcaactg aagcgttcct tgaagatcag ccatagagat atttttccca actaccaagc
    49861 cttcgatttg gtggaattgg tgactgtggg tcgcatcgtc cgtatcgcga cggaagacac
    49921 gccctggcga gatcatcttc aaaggacctt tagaaaaatc atgggcatcc atagcacgcg
    49981 cctgaactgg agacgtgtgg gtacggagca agatttcttc agtgatatag aaagtatcct
    50041 gcatatcacg agctgggtgg tcttttggaa ggttcatacg ttcaaagtta tagtagtctt
    50101 gctccacttc aaaaccatcc acgacttgat aacccatacc gatgaagata tcttcgattt
    50161 cttcactggt ttgtgtcaaa acgtgacggt gaccagtcgc aactggacga cctggaagcg
    50221 tcacatcgat actctcgcta gccagttgag acgcgacttt cttttcttcc aagagcttag
    50281 ctgtttcttc aaaagcagca gtcaagacat cacgagcttc attgacgtgt ttcccgatga
    50341 ttggacgcat ctcagcagaa acatctttca tccctttgag gatttcagtg agcgaaccct
    50401 ttttaccaag gacagagaca cgcaaatctt gcatctcttt ttcatttcca gcagtaatct
    50461 gcttcaagct agccagcgtt tcttcgcgaa gcgcttttaa ttgttcttca atagttgaca
    50521 tatttcctcc atcagtctct cgtagataaa aagaaaacca catgccaaaa actccactcg
    50581 gagcgttgac acgcggtacc atccgttttc atctgacaag tcagaccttc atttctaaat
    50641 ccatgcgcaa gtgaattcac ccagctttca tatagagagc ttgcagtcac ggctctcctc
    50701 cctgatatac ttcccttggg ctactagtct ttcagattcc tattcaatta ctacttagtt
    50761 tatcagattt ttaccattct tgcaagacct atcttacttc tgcttgttag cttattctta
    50821 tctaacttta tagcggattg aaataagatg aaaacaaatc gattgggaaa gtaaaattaa
    50881 tttctataaa tgttttagca attgtttcgt actattttag attcagtcta ctatatataa
    50941 cccatctatc ctaagttaac tatttataat cggctctctg taacaaaatt aaattaatta
    51001 atccccctat aaaataaaga ggtttagaat ttgatgtctt ccaaacctct ttatttcata
    51061 tttaatgaga tgttgcctta accgtgataa tatctaatca tcaataaaca aactatttga
    51121 ataaggattc tccatttgat tcaatcactc ctttatacca agtaaaggac attttcttat
    51181 atcgattgaa tgtgccattt ccatcatcat ttcgatcaac ataaatgaga ccgtaccttt
    51241 tagaaagttg tgcagtggac atagaaacgc agtcaataca tccccaagat gtatagccca
    51301 taatttccac accatcttgt agagcttcag ctacttgcaa taaatgttct ttcatatact
    51361 gaattctata atcatcttgg actgttaagt tattaaattc atcttttatt agttgatctt
    51421 tagcacctaa tccgttttcc actataaata atggaatttg ataacggtca taatatctat
    51481 ttaaaattat acgtagtcca attggatcaa tttgccatcc ccactcagaa gactctaaat
    51541 aaggatttac taagccacca ataatattcc cttctcctga attatactgt gttggaagag
    51601 cagattgagt cacactcatg taatagctaa aggataaaaa atctacagta taatttttta
    51661 ataactctgc atcttcagct gcaaactcta tgttaatgtc atgttcctta aaatatcttt
    51721 ttgcataatt cggataataa cctctaacat gcacatctga aaatagataa tttagattct
    51781 catactcatg agtcgcccat acatcttttg gatttggagt cattggataa gctggcatag
    51841 ctaataccat acaccccacc ttaaactctg aattaatctc acgagcaatt tttgtaacca
    51901 aactcgaggc gactaattca tgatgtatag cttgatataa ttcttgtttc gaaagattct
    51961 ccttaggtat atctattcct ccactagtaa acggtaattc caaaacagag tttacttcgt
    52021 taaatgtaag ccaatattta actttatctt tatacctttc taaaactgtt cgagcaaatt
    52081 tttcataaaa atgaatcatt ctcctatcaa tccatccatg atattttctt gctaaatata
    52141 atggagtctc atagtgtgaa agagttacaa gtggttctat cccgtgagca tgtagttcat
    52201 caaataattc atcataatat ttcaacccag cttcgttagg ttcttcttca tctccttttg
    52261 gaaaaattct actccatgca atagaagtac gaaaaacatt aaagcccatt tcagaaaaca
    52321 aggatatatc ttccttatat ttatgataaa aatcaatacc taacaatttt aagttatctt
    52381 ctgtaggatt ttctgttgct tctcctaatc cacctttggg taacacatcc tgaactgata
    52441 atcccttacc atcttcatta tatgctccct ctacttgatt agctgcaacc gctccacccc
    52501 aaagaaaatc atctggaaaa atggtcataa ctttcctcca ttataatatt gccagtaatt
    52561 ccttagaatg ctcgattgtc tgattattag gtaatactaa tacatctaga aaatcattgg
    52621 tattcgttac aattactggt gtaactgttt cgtagccttt agtcttgatt aaattcaagt
    52681 ccatttcaaa aatcaactga tttttgaaaa ctctgtctcc ttcttctaca tgactaataa
    52741 aaccttgacc ttttagctca acagtatcta atccaatatg aattagtaac tcaacaccct
    52801 catcactctt caatccaatt gcgtgcttag tcggaaaaat atttgtaatt ttcccatcaa
    52861 atggtgcata aaccttacct tcacttggga taatcgctac tccgtctcca attagtttat
    52921 ctgaaaatgt tttatcctgg acatcgctta acggaatgat ttctcctgat ataggagaaa
    52981 atatcatttt tttatttgaa actccagctt caacttctaa attgctagaa ctctcttctt
    53041 catcgattcc aaatatataa gctaatacaa aggtaataac aaccgaaatg accgccacaa
    53101 ttaaagcatt tacaatattt gatggcacat cagaataaat aaattgaggc aacgctatca
    53161 aagatgggac agcaaataga tatgctttaa cactagtaag acctgcaaat aatcccgcta
    53221 atccaccacc aatcatagct gcataaagcg gttttttata ttttaaagtc acaccatata
    53281 atgcaggttc ggtaatccct gcaagtaagg ctgagaaacc tgctgcaaaa gcaatttgtt
    53341 ttgtattatt atttttactc tttaatgcaa cagccatcga agcagcccct tgagctaagt
    53401 ttgaccctaa cattgctgga agaattaata cgtctggagt agcaatagat gccgccaaaa
    53461 aaataggtgc aaaagcccaa tgcattccag tcataacaat aaatggcata atagcaccaa
    53521 gaatagctaa tgtaagccat ccagctacac catacatttg cccaactaga tttgataatc
    53581 cttcaccaac aattactcca ataggtccga ctacaactaa ggcaatacag cttgatacta
    53641 ataatactag cgtaggttgc aaaaaactct tagtaatagc tggtgttaat ttagcaatta
    53701 ttttttcaat atatttcatc aaccaaacca taataagaat tggaacgact gatgaaccat
    53761 aactagctgg tgtcacaggt gcaccaaata aactaagagg attccctgat tgcaccattt
    53821 gaacaaaatt tggatggaga agtacacctg ctacagacat agctaatgta gatgttactt
    53881 ttaatttttg tgatgcagaa taagctaata acagcggtaa gaaataatat ggagcatccc
    53941 caaaaaatgt caaaaaagca atagtctgag aatctgattg caatatacca agcattggta
    54001 aaataattac caagactttc agcatacctc cccctaacat tgctggaatg attggagtca
    54061 tggaaccagc gatatactca atgattcttt ctaaaatatt ccctttgtac ccttgattaa
    54121 ctgaatcgga ttcaaaattg ccaagtttaa cgaattcttt ataataatta gctacatcat
    54181 taccaagtat aatttgatat tgtccatttt ttttcataat acctattaca cctggtatct
    54241 tcttcacatc atcatcattg actaaatttt catcttttaa ttctaatctt aaacgtgtta
    54301 cacaatgggt aactctattg acattttttt cacctccaat tacatcgagg attttttgta
    54361 ccgtatcttt ataactcatg gtattctcct attctattaa tctaaatttt ttgttaagcg
    54421 acgaatatga gccatcaaat aaactaattc actagaagtc agcaaataat tatactcagt
    54481 ttgtataaac attgccacct gttcaccaca ttcatattct ctaggatatt tatttttcat
    54541 taatgctaac aagtcttcat catcatcgtc acaataagtt gtattttcaa ccaagcgatg
    54601 ggcaaataat tttatatgag ttatgaatct ataataatca atagaatctt ggttaaactc
    54661 agtacaatag aaatcttgaa tgattttctc aattcccata attatttcag tgattttata
    54721 cgactcttga aaattatttt ctaaattagc attaacaaaa tgtagcgcta tgaatgcagc
    54781 ttcgtcaatt ggaagttcaa tacctaactc tttttttatt atttgtaaag cccttttccc
    54841 aagttcaaat tcttctttat aatatttcga gatttcccag cgtaggggat tcgaaataat
    54901 aactccttct ttataacgtt ctatgctcga agaaatatga tccgttaaat taatatagat
    54961 aatttcatca aaattattac ctaatgttat tttacctaga ttaattattt tttcggtgat
    55021 gtacaccaac tccaaaggaa cgttaataaa catctctgta aaacgggtca tattatctct
    55081 atttttgaga aaaaaacttt tctcaatatc aattggattt actttatctc cagtttttct
    55141 tccaaaagct attccccttc caaaaagaag aatatcgata tcttttttac tttgcgcaat
    55201 tacggcattg tggtttagta ttcgttttat gatcataaaa tttccctttt aaaataaaag
    55261 gaacctactt aaaaacatca agaaacttct tccgatgtga ttaaataggt tcctgctcac
    55321 ttgtattagt gataacatcc ttttatttca atttttaatg gtgacatgaa gcttaaataa
    55381 ttaataactc tgtaaccatt ttcattttaa gatatttcaa tctatttgtc aagtacttgt
    55441 agaaattttt ttattttgtg tgattcgaat gtgataatgg caacagtctc actaaagaaa
    55501 tgaaaatcat acatagaaat ttttaaaaat tttctctatc gtaaacctgc cactagttca
    55561 gaaactatac tagctgattc caaacgtaat atggtcatct catctacctt ccctaataat
    55621 ggcattgcac cataccaaac aatagtctta ttcaccaaaa gaataggcgt tactattttt
    55681 gattgagtaa aagacacttt aattttctgg ctcttcaact gtgaactac
//
LOCUS       DBERMM010000009        54113 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.009, whole genome shotgun sequence.
ACCESSION   DBERMM010000009 DBERMM010000000
VERSION     DBERMM010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 54113)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 54113)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..54113
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.009"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            5..75
                     /locus_tag="ACL8AS_000717"
     tRNA            5..75
                     /locus_tag="ACL8AS_000717"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:37..39,aa:Gly,seq:tcc)
     gene            110..183
                     /locus_tag="ACL8AS_000718"
     tRNA            110..183
                     /locus_tag="ACL8AS_000718"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:144..146,aa:Ile,seq:gat)
     gene            266..355
                     /locus_tag="ACL8AS_000719"
     tRNA            266..355
                     /locus_tag="ACL8AS_000719"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:302..304,aa:Ser,seq:tga)
     gene            366..439
                     /locus_tag="ACL8AS_000720"
     tRNA            366..439
                     /locus_tag="ACL8AS_000720"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:400..402,aa:Met,seq:cat)
     gene            443..515
                     /locus_tag="ACL8AS_000721"
     tRNA            443..515
                     /locus_tag="ACL8AS_000721"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:476..478,aa:Phe,seq:gaa)
     gene            528..608
                     /locus_tag="ACL8AS_000722"
     tRNA            528..608
                     /locus_tag="ACL8AS_000722"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:562..564,aa:Tyr,seq:gta)
     gene            613..683
                     /locus_tag="ACL8AS_000723"
     tRNA            613..683
                     /locus_tag="ACL8AS_000723"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:645..647,aa:Trp,seq:cca)
     gene            698..770
                     /locus_tag="ACL8AS_000724"
     tRNA            698..770
                     /locus_tag="ACL8AS_000724"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:731..733,aa:His,seq:gtg)
     gene            781..852
                     /locus_tag="ACL8AS_000725"
     tRNA            781..852
                     /locus_tag="ACL8AS_000725"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:813..815,aa:Gln,seq:ttg)
     gene            862..945
                     /locus_tag="ACL8AS_000726"
     tRNA            862..945
                     /locus_tag="ACL8AS_000726"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:896..898,aa:Leu,seq:caa)
     gene            complement(1056..1787)
                     /locus_tag="ACL8AS_000727"
     CDS             complement(1056..1787)
                     /locus_tag="ACL8AS_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001074368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HGS1228624.1"
                     /translation="MAKLYAISDIHGYLDEFRDALNKVNLNDKDNRLFLLGDYLDNGL
                     QSFQVISKIIELEEVYPNQIITLLGNHEEWFYDWLILDKPTASAFPETIKSFFSPEEL
                     NYIFKSNANNFETGVRNEIKNNIKFNPFINWFKKRYRDKRYYETDTQIFVHAGIDEEA
                     GKLWKELTSSEIFTNKFPITTGRFHKAIISGHIASWEVAKDRRYLGKIYYDSKSHYFI
                     DGDVTNSKTIPILCYDTITQKYHFL"
     gene            complement(1780..2016)
                     /gene="relB"
                     /locus_tag="ACL8AS_000728"
     CDS             complement(1780..2016)
                     /gene="relB"
                     /locus_tag="ACL8AS_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB family
                     antitoxin"
                     /protein_id="HGS1228625.1"
                     /translation="MNNVVTTQISIQLSQELNSLLNAIVEENNTTKTDFIRQAVIEKI
                     EDMYDIKVADEAYKKWVECGKKAISHEEMMRRYG"
     gene            complement(2232..2669)
                     /locus_tag="ACL8AS_000729"
     CDS             complement(2232..2669)
                     /locus_tag="ACL8AS_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HGS1228626.1"
                     /translation="MDTSQVIKAHEVAKKAHFGQIDRAGIDYIKHPETVASFVATDEE
                     KAVAYLHDVIEDTSLTLLDLKKEGFSKNIIEAVDILTKKKGQDYQSYLNLVKKNELAR
                     VVKLADLRHNSDLTRLPLITEKDLERNKKYSSAIRFLRAKKKS"
     gene            complement(2710..3843)
                     /locus_tag="ACL8AS_000730"
     CDS             complement(2710..3843)
                     /locus_tag="ACL8AS_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HGS1228627.1"
                     /translation="MAIRKGKDGNWVVDISNGFDPITLKQRRLVRKGYKTKKEAIEAE
                     HYLRSVELKERFYGAKITISILYELLKEEDSINHRKASYINTQDNNYNKHIKDYFSMV
                     DNVGKLTYEDIYQFREHLRQKVAKNSDKPLSTNTINKIMILLKKIFDVGLRKGYYSSN
                     PAKLIKKLPIEKTKMQFWTVKEFQKFLTLFEPEEYNIKLLFTVLFFTGLRLGEALALT
                     WQDIDFSSNTIHITKSVYVNKGVTHISTTKTKAGTRRIVINKKLSQELQDWEKRQKHL
                     LEQFTNNSLTLQVFQNSPITITKNAIEKQYKKIIERDSTLKKIRIHDFRHSHASLLIN
                     QGEDYLVVKERLGHASITTTIDTYSHLYPSKQKDLADKLDDLL"
     gene            complement(3847..3969)
                     /locus_tag="ACL8AS_000731"
                     /pseudo
     CDS             complement(3847..3969)
                     /locus_tag="ACL8AS_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823627.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3173 family protein"
     gene            complement(3963..4340)
                     /locus_tag="ACL8AS_000732"
                     /pseudo
     CDS             complement(3963..4340)
                     /locus_tag="ACL8AS_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004195527.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Rep protein"
     gene            complement(4616..5170)
                     /locus_tag="ACL8AS_000733"
     CDS             complement(4616..5170)
                     /locus_tag="ACL8AS_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228628.1"
                     /translation="MPKLLETEKYSLDSIIDGGKLRMISKFCPDLHGLRYEFKTSDSI
                     TKEYCKKIRQALRDSDPEGKSGKKCMMRYTIDILNVWNTLCRTRDFITGSLKADDVID
                     GKTGIYFFDVNTSNVITDDVIENVKINHKSLVRNVDEENIESISKEIPKGTDMYYYVL
                     YRLGLNRIKYNYLVKALAGAIQKD"
     gene            complement(5341..5817)
                     /locus_tag="ACL8AS_000734"
     CDS             complement(5341..5817)
                     /locus_tag="ACL8AS_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228629.1"
                     /translation="MSRTYINIRLAYETKYWLECIQEEVQKKLDALINEQDIEELESI
                     ITNKLEKKDSLLGAVSITTFFKVSSSSVIEKAYNETKNYTTSEWREIARQMNLAKVKQ
                     NMEIGTLTPRLYLDNNIISELEKYQFLFKSDDMIRQVRMSYVIKMVAFAYYKKLFA"
     gene            5977..6225
                     /locus_tag="ACL8AS_000735"
     CDS             5977..6225
                     /locus_tag="ACL8AS_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000967644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228630.1"
                     /translation="MLYWISVNYEITEDEDFETVKTRVISDFESYLKLLNGKFEESLK
                     KVIKSFTFSKLIGEKLCNGEDLKNLSKEIRHQIQDRNS"
     gene            6488..7765
                     /locus_tag="ACL8AS_000736"
     CDS             6488..7765
                     /locus_tag="ACL8AS_000736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamylcysteine synthetase"
                     /protein_id="HGS1228631.1"
                     /translation="MSCSIDLLKHRYLKNIKENPELFVGIELEYPVASLEGDATDVEV
                     IKDLFHYLVSTLDLTVAKVDDFGNLIQLVDPISQDAILFEVSYTTIEFAFGKAETIQE
                     VENRFNNYMNVIQRKLAESNHAIVGCGIHPNWDKNENCPVAYPRYQMLMDYLNLSRNI
                     IKSDLHHFPEYGTFICGSQVQLDISKTNYLRVINAFTQIEAAKAYLFANSEFSGADWD
                     TKISRDIFWEESMHGIYPENVGVNARLLNDEADFFDYLNHSAIFTAERDGQTYYFYPI
                     QAGDYLATPEIQAFALNGDEVIISPQEKDFETHRSYQYQDLTTRGTVEFRSVCTQPLD
                     RTFASAAFHLGLLVNLDKLEAYLETAPFFKVFGYDYKSLRRQFSKKNLTDEEETTIIE
                     FSKDLLLLAEEGLVVRNKEEMTYLQPLREELSL"
     gene            7841..9325
                     /gene="thrC"
                     /locus_tag="ACL8AS_000737"
     CDS             7841..9325
                     /gene="thrC"
                     /locus_tag="ACL8AS_000737"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004795 - threonine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HGS1228632.1"
                     /translation="MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLDF
                     DKLKDTSYQEVAKLVLSAFLDDFTAEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLE
                     LFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFADVPGT
                     EIIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTT
                     NKLQFSSANSMNIGRLVPQIVYYVYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAF
                     YAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSMDILVSSNLERLIF
                     HLLGNNAEKTTELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDS
                     YIEDPHTAVASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEAL
                     AQLHEISGVAVPPAVDGLEIAPIRHKTTVAAADMQAAVEAYLGL"
     gene            9386..10666
                     /locus_tag="ACL8AS_000738"
     CDS             9386..10666
                     /locus_tag="ACL8AS_000738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HGS1228633.1"
                     /translation="MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGV
                     SVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFL
                     SIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
                     SFLSNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDK
                     ELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATA
                     TVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVE
                     ASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVL
                     GWGLPGIWAGSLLDNGFRWLFLRYRYQRYMSLKG"
     gene            10670..11290
                     /locus_tag="ACL8AS_000739"
     CDS             10670..11290
                     /locus_tag="ACL8AS_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001172828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HGS1228634.1"
                     /translation="MQKTAFIWDLDGTLLDSYEAILSGIEETFAQFSIPYDKEKVREF
                     IFKYSVQDLLVRVAEDRNLDVEVLNQVRAQSLAEKNAQVVLMPGAREVLAWADESGIQ
                     QFIYTHKGNNAFTILKDLGVESYFTEILTSQSGFVRKPSPEAATYLLDKYQLNSDNTY
                     YIGDRTLDVEFAQNSGIQSINFLESTYEGNHRIQALADISRIFETK"
     gene            11456..12568
                     /locus_tag="ACL8AS_000740"
     CDS             11456..12568
                     /locus_tag="ACL8AS_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HGS1228635.1"
                     /translation="MKKRMLLASTVALSFAPVLATQAEEVLWTARSVEQIQNDLTKTD
                     NKTSYTVQYGDTLSTIAEALGVDVTVLANLNKITNMDLIFPETVLTTTVNEAEEVTEV
                     EIQTPQADSSEEVTTATADLTTNQVTVDDQTVQVADLSQPIAEVTKTVIASEEVAPST
                     GTSVPEEQTTETTRPVEEATPQETTPAEKQETQASPQAASAVEVTTTSSEAKEVASSN
                     GATAAVSTYQPEETKVISTTYEAPAAPDYAGLAVAKSENAGLQPQTAAFKEEIANLFG
                     ITSFSGYRPGDSGDHGKGLAIDFMVPERSELGDKIAEYAIQNMASRGISYIIWKQRFY
                     APFDSKYGPANTWNPMPDRGSVTENHYDHVHVSMNG"
     gene            12996..13420
                     /locus_tag="ACL8AS_000741"
                     /pseudo
     CDS             12996..13420
                     /locus_tag="ACL8AS_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890080.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
     gene            13431..13790
                     /locus_tag="ACL8AS_000742"
     CDS             13431..13790
                     /locus_tag="ACL8AS_000742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1304 domain-containing protein"
                     /protein_id="HGS1228636.1"
                     /translation="MSIILTTIVALEHFYIFYLESIATQSDATSRVFNMEKEELAHPS
                     VSSLFKNQGIYKALLGVFLLYVIYFSQNLEIVTIFVLFVIGAATYGSLTADKKIILKQ
                     GGSAILALISILLFKYT"
     gene            13897..14541
                     /gene="pcp"
                     /locus_tag="ACL8AS_000743"
     CDS             13897..14541
                     /gene="pcp"
                     /locus_tag="ACL8AS_000743"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA];
                     GO_function: GO:0016920 - pyroglutamyl-peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HGS1228637.1"
                     /translation="MKVLVTGFEPFGGEKGNPTLETIKGLPAEIHGAEVRWLEVPTVF
                     HKSAQVLEEEMNRYQPDFVLCIGQAGGRTSLTPERVAINQDDARTSDNEDNQPIDRPI
                     RLDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVK
                     AGFMHIPYMMEQVVNRQTTPAMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH"
     gene            complement(14569..15426)
                     /locus_tag="ACL8AS_000744"
     CDS             complement(14569..15426)
                     /locus_tag="ACL8AS_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HGS1228638.1"
                     /translation="MNYPKIDLKTIRQESKHFQADTPRLFLLYILPSMLVILSSFLNP
                     LSRIHGTVLEQPFFSILGQILQAYLFPLLVSFIGTILLTSSVYATLTLMKDSKTEPSV
                     KNSLALFDEERFSQTFLTLLLKRFYLFLWSIPNLLGIHLLFYSSFLAKKFVTLHPEFP
                     SLDLSSVETERFLMVFGLYFLASLILIIVGNILYIPQYYAYSQVEFLLCYSLDLGQVP
                     PRRILKTSRSFMKGYKFQHFVLDLQLLPWYFLNWITFGIASFSLLPYIQCTKIMFYRA
                     VLARKRPKA"
     gene            15556..16698
                     /gene="tgt"
                     /locus_tag="ACL8AS_000745"
     CDS             15556..16698
                     /gene="tgt"
                     /locus_tag="ACL8AS_000745"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004298827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HGS1228639.1"
                     /translation="MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQAT
                     VKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQV
                     YSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYD
                     YVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSI
                     GGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTR
                     IARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIR
                     LTSYHNLYFLLNLMKQVRQAIMDDNLLEFREYFVEKYGYNKSGRNF"
     gene            16799..18616
                     /locus_tag="ACL8AS_000746"
     CDS             16799..18616
                     /locus_tag="ACL8AS_000746"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase family protein"
                     /protein_id="HGS1228640.1"
                     /translation="MRIKWFSLVRITGLLLVLLYHFFQTIFPGGFFGVDVFFTFSGFL
                     ITALLIEEFSKNHEIDLIGFFRRRFYRIVPPVVLMVLVTMPFTFLVRQDYVAGIGGQI
                     ASVLGFMTNFYELLTGGSYESQFIPHLFVHNWSLAVEVHYYILWGLAVWFLSKQAKSN
                     GQLKGMVFLLSAVAFLISFFSMFIGSFLVTSYSSVYFSSLTHVYPFFLGSMLATIVGV
                     RQTTSLVKQLDKIWDLRKTLVVFGGGFGFLVLLTFFVKFTYLFAYLIGFLLASLAALA
                     MILAARVLHEKTHHIQEPKIISFLADTSYAVYLFHWPFYIIFSQLTSNLLAVLLTLIC
                     SYGFASLSFYVLEPWIAGKNTPIVQTLRPLPYIHAILAAGTGILTIIVCTVTLLAPQV
                     GAFETDLTVNGLKQAATNIGQTKVMAERADANSLGIADGTMLIGDSVALRANTALQTA
                     LPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDWDSIVKNLP
                     KGHHMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITIADWNQVAKEHPEIWAG
                     TDQVHFGSESSTIEAGAKLYADTIATALQTAQDKPVKSK"
     gene            18769..19920
                     /gene="nagA"
                     /locus_tag="ACL8AS_000747"
     CDS             18769..19920
                     /gene="nagA"
                     /locus_tag="ACL8AS_000747"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008448 - N-acetylglucosamine-6-phosphate
                     deacetylase activity [Evidence IEA];
                     GO_process: GO:0006044 - N-acetylglucosamine metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HGS1228641.1"
                     /translation="MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVID
                     YTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQ
                     LLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
                     NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYN
                     GMRGLTHRELGMVGAMYQLPHTYAELICDGHHVDPKACEILIKQKGTENIALITDCMT
                     AGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVM
                     MASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA"
     gene            20083..21141
                     /locus_tag="ACL8AS_000748"
     CDS             20083..21141
                     /locus_tag="ACL8AS_000748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="HGS1228642.1"
                     /translation="MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHI
                     IKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYA
                     HCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
                     LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVN
                     SSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEF
                     DLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSK
                     AADHHAIKVIIENDISEA"
     gene            21292..21657
                     /locus_tag="ACL8AS_000749"
     CDS             21292..21657
                     /locus_tag="ACL8AS_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1033 family protein"
                     /protein_id="HGS1228643.1"
                     /translation="MYRVIEMYGDFKPWWFLEGWEEDIVASRKFDQYYDALKYYKTCW
                     FRLEQESPLYKSRSDLMTIFWDPEDQRWCDECDEYLQQYHSLALLQDEQVIPDEKLRS
                     GYEKQTSQERNRSCRMKLK"
     gene            21733..22674
                     /gene="comGA"
                     /locus_tag="ACL8AS_000750"
     CDS             21733..22674
                     /gene="comGA"
                     /locus_tag="ACL8AS_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000249584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus ATPase ComGA"
                     /protein_id="HGS1228644.1"
                     /translation="MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIG
                     SYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESL
                     VIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
                     VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDIETARAVV
                     RASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFAN
                     RDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS"
     gene            22622..23638
                     /gene="comGB"
                     /locus_tag="ACL8AS_000751"
     CDS             22622..23638
                     /gene="comGB"
                     /locus_tag="ACL8AS_000751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000355375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus assembly protein ComGB"
                     /protein_id="HGS1228645.1"
                     /translation="MDISQVFRLRRKKLATAKQKNIITLFNNLFSSGFHLVETISFLD
                     RSSLLDKQCVTQMRTGLSQGKSFSEMMESLGCSSTIVTQLSLAEVHGNLHLSLGKIEE
                     YLDNLAKVKKKLIEVATYPLILLGFLLLIMLGLRNYLLPQLDSSNIATRIIGNLPQIF
                     LVMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQ
                     GMELTQIFQMMQEQGSQLFKEIGQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGE
                     VKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIVLLYAAMLMPMYQNM
                     EVNF"
     gene            23640..23966
                     /gene="comGC"
                     /locus_tag="ACL8AS_000752"
     CDS             23640..23966
                     /gene="comGC"
                     /locus_tag="ACL8AS_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="comG operon protein ComGC"
                     /protein_id="HGS1228646.1"
                     /translation="MKKMMTFLKKAKVKAFTLVEMLVVLLIISVLFLLFVPNLTKQKE
                     AVNDKGKAAVVKVVESQAELYSLEKNEDASLSKLKEDGRITEEQAKAYKEYNDKNVGA
                     NRKVND"
     gene            23959..24363
                     /gene="comGD"
                     /locus_tag="ACL8AS_000753"
     CDS             23959..24363
                     /gene="comGD"
                     /locus_tag="ACL8AS_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGD"
                     /protein_id="HGS1228647.1"
                     /translation="MIKAFTMLESLLVLGLVSILALGLSGSVQSTFAAVEEQIFFMEF
                     EELYRETQKRSVASQQKTNLNLDGQTLSNGSQKLTVPKGIQAPSGQSITFDRAGGNSS
                     LAKVEFQTSKGAIRYQLYLGNGKIKRIKETKN"
     gene            24326..24628
                     /gene="comGE"
                     /locus_tag="ACL8AS_000754"
     CDS             24326..24628
                     /gene="comGE"
                     /locus_tag="ACL8AS_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGE"
                     /protein_id="HGS1228648.1"
                     /translation="MEKLNALRKQKIRAVILLEAVVALAIFASIATLLLGQIQKNRQE
                     EAKILQKEEVLRVAKMALQTGQNQVSINGVEIQVFSSEKGLEVYHGSEQLLAIKEP"
     gene            24591..25052
                     /gene="comGF"
                     /locus_tag="ACL8AS_000755"
     CDS             24591..25052
                     /gene="comGF"
                     /locus_tag="ACL8AS_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000250539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGF"
                     /protein_id="HGS1228649.1"
                     /translation="MVQNSCWQSKSHKVKAFTLLESLLALIVISGGLLLFQTMSQLLI
                     SEVRYQQQSEQKEWLLFVDQLEAELDRSQFEKVEGNRLYMKQDGKDIAIGKSKSDDFR
                     KTNARGRGYQPMVYGLKSAQITEDNQLVHFRFQFQKGLEREFIYRVEKEKS"
     gene            25030..25443
                     /gene="comGG"
                     /locus_tag="ACL8AS_000756"
     CDS             25030..25443
                     /gene="comGG"
                     /locus_tag="ACL8AS_000756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGG"
                     /protein_id="HGS1228650.1"
                     /translation="MWKKKKVKAGVLLYAVTIAAIFSLLLQFYLNRQVAHYQDYALNK
                     EKLVAFAMAKRTKDKVEQESGEQVFNLGQVSYQNKKTGLVTRVRTDKSQYEFLFPSVK
                     IKEEKRDKKEEVATDSSEKVEKKKSEEKPEKKENS"
     gene            25580..26174
                     /locus_tag="ACL8AS_000757"
                     /pseudo
     CDS             25580..26174
                     /locus_tag="ACL8AS_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679792.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
     gene            26235..27188
                     /locus_tag="ACL8AS_000758"
     CDS             26235..27188
                     /locus_tag="ACL8AS_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HGS1228651.1"
                     /translation="MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGET
                     ELEQVKDNNQTLKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIV
                     EELFKEEEITILEMGSGMGILGATFLTSLTKKVDYLGMEVDDLLIDLAASMADVIGLQ
                     AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYTHHLLMEQGL
                     KYLKSDGYAIFLAPSDLLTSPQSNLLKVWLKEEASLVAMISLPENLFANAKQSKTIFI
                     LQKKSEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI"
     gene            27239..28429
                     /locus_tag="ACL8AS_000759"
     CDS             27239..28429
                     /locus_tag="ACL8AS_000759"
                     /EC_number="2.7.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008776 - acetate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006085 - acetyl-CoA biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HGS1228652.1"
                     /translation="MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTV
                     KFDGRSEQQILDIENHTQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTV
                     VEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRY
                     PLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKA
                     GKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLG
                     VSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADAIVFTAGVGE
                     NAESFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVE
                     RLKK"
     gene            28430..28561
                     /locus_tag="ACL8AS_000760"
     CDS             28430..28561
                     /locus_tag="ACL8AS_000760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000768902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228653.1"
                     /translation="MKLKKYSIQGVGKVIFPASFSDEIVQNLAMIGFFEKYGIIVVI"
     gene            28578..28949
                     /gene="rnpA"
                     /locus_tag="ACL8AS_000761"
     CDS             28578..28949
                     /gene="rnpA"
                     /locus_tag="ACL8AS_000761"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000049 - tRNA binding [Evidence IEA];
                     GO_function: GO:0004526 - ribonuclease P activity
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HGS1228654.1"
                     /translation="MKKNFRVKREKDFKAIFKEGTSFANRKFVVYQLENQKNHFRVGL
                     SVSKKLGNAVTRNQIKRRIRHIIQNAKGSLVEDVDFVVIARKGVETLGYAEMEKNLLH
                     VLKLSKIYREGNGSEKETKVD"
     gene            28924..29748
                     /locus_tag="ACL8AS_000762"
     CDS             28924..29748
                     /locus_tag="ACL8AS_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HGS1228655.1"
                     /translation="MKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYF
                     FAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYP
                     GRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFL
                     WINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAP
                     GGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK"
     gene            29767..30753
                     /gene="jag"
                     /locus_tag="ACL8AS_000763"
     CDS             29767..30753
                     /gene="jag"
                     /locus_tag="ACL8AS_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding cell elongation regulator Jag/EloR"
                     /protein_id="HGS1228656.1"
                     /translation="MVVFTGSTVEEAIQKGLKELDIPRMKAHIKVISREKKGFLGLFG
                     KKPAQVDIEAISETTVVKANQQVVKGVPKKINDLNEPVKTVSEETVDLGHVVDAIKKI
                     EEEGQGISDEVKAEILKHERHASTILEETGHIEILNELQIEEAMREEAGADDLETEQD
                     QAESQELEDLGLKVETNFDIEQVATEVMAYVQTIIDDMDVEATLSNDYNRRSINLQID
                     TNEPGRIIGYHGKVLKALQLLAQNYLYNCYSRTFYITINVNDYVEHRAEVLQTYAQKL
                     AIRVLEEGRSHQTDPMSNSERKIIHRIISRMDGVTSYSEGDEPNRYVVVDTE"
     gene            30804..31427
                     /locus_tag="ACL8AS_000764"
     CDS             30804..31427
                     /locus_tag="ACL8AS_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HI_0552 family protein"
                     /protein_id="HGS1228657.1"
                     /translation="MLNKIRDYLDFAGLQYRNPDKAGAEREKMLAFRHKGQEARKAFT
                     ELAKAFQASHPEWQLQQTSQWMNQAQRLRPHFWVYLQRDGQVTEPMIALRLYGNPSDF
                     GISLEVSFIERKKDEQTLGKQAKVLEIPTVKGIYYLTYSNGQSQRWEANEEKRRTLRE
                     KVRSQEVRKVLVKVDVPMTENSSEEEIVEGLLKSYSKILPYYQVTRG"
     gene            31556..33013
                     /locus_tag="ACL8AS_000765"
     CDS             31556..33013
                     /locus_tag="ACL8AS_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HGS1228658.1"
                     /translation="MEVVSNVLNWFSSNILQNPAFFVGLLVLIGYALLKKPAHDVFSG
                     FVKATVGYMLLNVGAGGLVTTFRPILAALNYKFQIGAAVIDPYFGLAAANNKIAAEFP
                     DFVGTATTALLIGFGINILLVALRKITKVRTLFITGHIMVQQAATVSLMVLFLVPQLR
                     NAYGTAAIGIICGLYWAVSSNMTVEATQRLTGGGGFAIGHQQQFAIWFVDKVAGRFGK
                     KEESLDNLKLPKFLSIFHDTVVASATLMLVFFGAILLILGPDIMSNKEVITSGTLFNP
                     AKQDFFMYIIQTAFTFSVYLFVLMQGVRMFVSELTNAFQGISNKLLPGSFPAVDVAAS
                     YGFGSPNAVLSGFTFGLIGQLITIVLLIVFKNPILIITGFVPVFFDNAAIAVYADKRG
                     GWKAAVILSFISGVLQVALGALCVALLDLASYGGYHGNIDFEFPWLGFGYIFKYLGIV
                     GYVLVCLFLLVIPQLQFAKAKDKEKYYNGEVQEEA"
     gene            33036..33317
                     /locus_tag="ACL8AS_000766"
     CDS             33036..33317
                     /locus_tag="ACL8AS_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1228659.1"
                     /translation="MVKVLAACGNGMGSSMVIKMKVENALRKLNQTDFTVNSCSVGEA
                     KGLAVGYDIVIASLHLIQELEGRTNGKLIGLDNLMDDKEITEKLSQALQ"
     gene            33394..33879
                     /locus_tag="ACL8AS_000767"
     CDS             33394..33879
                     /locus_tag="ACL8AS_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002267837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HGS1228660.1"
                     /translation="MNLKQALIDNDSIRLGLEANDWKEAVKVAVDPLIESGAILPEYY
                     DAIIESTEEYGPYYILMPGMAMPHARPEAGVQSDAFSLITLQNPVVFSDGKEVSVLLA
                     LAATSSKIHTSVAIPQIIALFELEDSIARLQACQTKEDVLAMIEESKDSPYLEGLDLE
                     S"
     gene            33896..34561
                     /locus_tag="ACL8AS_000768"
     CDS             33896..34561
                     /locus_tag="ACL8AS_000768"
                     /EC_number="4.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-keto-L-gulonate-6-phosphate decarboxylase
                     UlaD"
                     /protein_id="HGS1228661.1"
                     /translation="MTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQV
                     GSELAEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALK
                     AIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNK
                     VKKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRGITEAVDPAGAARAFKDEIKR
                     IWG"
     gene            34565..35428
                     /locus_tag="ACL8AS_000769"
     CDS             34565..35428
                     /locus_tag="ACL8AS_000769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000252119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016861 - intramolecular oxidoreductase
                     activity, interconverting aldoses and ketoses [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 3-epimerase"
                     /protein_id="HGS1228662.1"
                     /translation="MVRPIGIYEKATPTHFTWLERLNFAKELGFDFIEMSIDERDERL
                     ARLDWSKEERLEVVKEIYETGVRIPSICFSGHRRYPLGSKDSVLEEKSLELMKKCIEL
                     AQDLGVRTIQLAGYDVYYEEKSPQTRQRFIKNLRKACDWAEEAQVVLAIEIMDDPFIN
                     SIEKYLAIEKEIDSPFLFVYPDIGNVSAWHNDIYSEFYLGHHAIAALHLKDTYAVTES
                     SKGQFRDVPFGQGCVKWEEAFDILKETNYNGPFLIEMWSENCETVEETRAAIQEAQAF
                     LYPLIKKAGLM"
     gene            35430..36134
                     /locus_tag="ACL8AS_000770"
     CDS             35430..36134
                     /locus_tag="ACL8AS_000770"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HGS1228663.1"
                     /translation="MNQVINAMRKRVCDANQSLPKHGLVKFTWGNVSEVNRELGVIVI
                     KPSGVDYDELTPENMVVTDLDGKILEGDLRPSSDLPTHVQLYKAWSEIGSVVHTHSTE
                     AVAWAQAGRDIPFYGTTHADYFYGSIPCARSLTKDEVEVAYEKDTGLVIVEEFEHRGL
                     NPVEVPGIVVRNHGPFTWGKNPENAVYHSVVLEEVSKMNRFTEQINPRVEPAPQYILE
                     KHYQRKHGPNAYYGQK"
     gene            36315..37988
                     /locus_tag="ACL8AS_000771"
     CDS             36315..37988
                     /locus_tag="ACL8AS_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HGS1228664.1"
                     /translation="MVLDKASCDLLQYLMDQETSKTIMAISKDLKESRRKIYYHIDKI
                     NAALGDEALHIISIPRIGIHLTEEQRDACCKLLSEVDSYDYIMSAHERMMIMLLWIGI
                     SKERITIEKLIELTEVSRNTVLNDLNSIRYQLTLEQYQVTLQVSKSQGYHLHAHPLNK
                     IQYLQSLLYHIFMEENATFVSILEDKMKERLDDECLLSVEMNQFFKEQVPLVEQDLGK
                     KINHHEITFMLQVLPYLLLSCHNVEQYQERHQDIEKEFSLIRKRIEYQVSKKLGERLF
                     QKFEISLSGLEVSLVAVLLLSYRKDLDIHAESDDFRQLKLALEEFIWYFESQIRMEIE
                     NKDDLLRNLMIHCKALLFRKTYGIFSKNPLTKQIRSKYGELFLVTRKSAEILEGAWFI
                     RLTDDDIAYLTIHIGGFLKYTPSSQKNMKKVYLVCDEGVAVSRLLLKQCKLYFPNEQI
                     DTVFTTEQFKSVEDIAQVDVVITTNDDLDSRFPILRVNPILEAEDILKMLDYLKHNIF
                     RNKSKSFSENLSSLISSYIVDSKLASKFQEEVQTLINQEIVVQAFLEDI"
     gene            38100..39191
                     /gene="ulaG"
                     /locus_tag="ACL8AS_000772"
     CDS             38100..39191
                     /gene="ulaG"
                     /locus_tag="ACL8AS_000772"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030145 - manganese ion binding [Evidence
                     IEA];
                     GO_function: GO:0035460 - L-ascorbate 6-phosphate
                     lactonase activity [Evidence IEA];
                     GO_process: GO:0019854 - L-ascorbic acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-ascorbate 6-phosphate lactonase"
                     /protein_id="HGS1228665.1"
                     /translation="MPNVKEITRESWILATFPEWGTWLNEEIEEEVVPEGNFAMWWLG
                     NCGTWIKTPAGANVVMDLWSNRGKSTKKVKDMVRGHQMANMAGVRKLQPNLRVQPMVI
                     DPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKE
                     RIIVVKPGDTIELKDMKIHAVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKA
                     VNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNNYGENPVGIQDKMTSIDLLR
                     MAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQ
                     DQHLVEYHHPRGFDDCFEQDSNIQFKALL"
     gene            39304..41280
                     /gene="tkt"
                     /locus_tag="ACL8AS_000773"
     CDS             39304..41280
                     /gene="tkt"
                     /locus_tag="ACL8AS_000773"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004802 - transketolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HGS1228666.1"
                     /translation="MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLH
                     INPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMNEIKSFRQWGSKTPGHPEF
                     GHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEG
                     VSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGT
                     DLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALG
                     WDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEVHPELAAEVEAIIDGRDP
                     VEVTPADFPALENGFSQATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQ
                     DDANRLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGL
                     PVTYVFTHDSIAVGEDGPTHEPVEHLAGLRAMPNLNVFRPADARETQAAWYLAVTSEK
                     TPTALVLTRQNLTVEDGTDFDKVAKGAYVVYENAADFDTILIATGSEVNLAVSAAKEL
                     ASQGEKIRVVSMPSTDVFDKQDAAYKEEILPNAVRRRVAVEMGASQNWYKYVGLDGAV
                     LGIDTFGASAPAPKVLAEYGFTVENLVKVVRNLK"
     gene            41397..41696
                     /gene="yajC"
                     /locus_tag="ACL8AS_000774"
     CDS             41397..41696
                     /gene="yajC"
                     /locus_tag="ACL8AS_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HGS1228667.1"
                     /translation="MNPNITFLIMLVGMMALMFFMQRSQKKQAQKRMESLNKLQKGYE
                     VITIGGLYGTVDEVDTEKGTIVLDVDGVYLTFELAAIKTVLPLKETASLEGAIEK"
     gene            41742..42170
                     /locus_tag="ACL8AS_000775"
     CDS             41742..42170
                     /locus_tag="ACL8AS_000775"
                     /EC_number="3.1.3.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA];
                     GO_process: GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight
                     protein-tyrosine-phosphatase"
                     /protein_id="HGS1228668.1"
                     /translation="MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNP
                     IHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYIIGMDASNISDLRQMCPVDCQDK
                     IYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES"
     gene            42172..42582
                     /locus_tag="ACL8AS_000776"
     CDS             42172..42582
                     /locus_tag="ACL8AS_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MORN repeat-containing protein"
                     /protein_id="HGS1228669.1"
                     /translation="MENLTNFYEKYRVYLTRPRLELLAVVTIVFCAVLVFFLNIPGKG
                     VLKLDNGTIVYDGSLVRGKMNGQGTITFQNGDQYTGGFNNGAFNGKGTFQSKEGWTYE
                     GDFVNGQAEGKGKLTTEQEVVYEGTFKQGVFQQK"
     gene            42882..45533
                     /gene="adhE"
                     /locus_tag="ACL8AS_000777"
                     /gene_synonym="adhC"
     CDS             42882..45533
                     /gene="adhE"
                     /locus_tag="ACL8AS_000777"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA];
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006066 - alcohol metabolic process
                     [Evidence IEA];
                     GO_process: GO:0015976 - carbon utilization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HGS1228670.1"
                     /translation="MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDY
                     IVAKASVAALDAHGELALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEE
                     DDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHA
                     ARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGK
                     PALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAE
                     FKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKPATWIAEQAGFTVPE
                     GTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIH
                     TADEELTKEFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVS
                     AINLLNIKKVGRRRNNMQWMKLPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGF
                     LDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGGGSPMDA
                     AKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFA
                     VISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMA
                     SDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNASTIAGMAFANAFLGISHSMAH
                     KIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPA
                     STPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRKLAFLAYEDQCSPANP
                     RLPMVDHMQEIIEDAYYGYKERPGRRK"
     gene            complement(46322..46630)
                     /locus_tag="ACL8AS_000778"
     CDS             complement(46322..46630)
                     /locus_tag="ACL8AS_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HGS1228671.1"
                     /translation="MTEEMEYICFQLIANSGAAKSSFIEAIQLAKAGNLKEAKIKVEE
                     AEDSLVEAHKIHSNLIQKEATGEKIGFSLLFMHAEDQMASTEIIQLLSKEFIDLYQNK
                     "
     gene            complement(46627..46935)
                     /locus_tag="ACL8AS_000779"
     CDS             complement(46627..46935)
                     /locus_tag="ACL8AS_000779"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1228672.1"
                     /translation="MKQILLVCNAGMSTNMLVKKMQQSATERGIEISIQAKSMTEAKK
                     NIHEADVILIGPQIRYELLAVKEIAGNIPVDTIDMRDYGMMNGAKVLEQALAWIGEIR
                     "
     gene            complement(46940..48235)
                     /locus_tag="ACL8AS_000780"
     CDS             complement(46940..48235)
                     /locus_tag="ACL8AS_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000798148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HGS1228673.1"
                     /translation="MKNSKFIDQFATFAGKLGNQIHLKTLRDAFVTVMPLYILAGLIV
                     LLNNTVFKWIFQGDTLTRFQYWGITIANGTLSISGMIIAVMVGYFLAKNRDFENPLAA
                     SMLSLVSLIVMMPNTVSVVPDGAKDAVNISGVLSFNNTGTGAMFAGVIVAIIATELFI
                     ELSNVKALQMNLGENIPPAVSRSFSVLLPVMTVISLFGVVSALLFNITGMNLISIITI
                     FIQEPIRHIGTSLIGVIIIYSLGNMLWLFGIHQAVIYSAILEPLLLINITENITAANN
                     GQAIPHIINLSQIQTFALMGGSGSTLCLLIATFLVSRNAVSKNVAKLSFGPGIFNINE
                     PVLFGYPIVYNISLAIPFITVPVLGILISYLATVTGFMSPAFIQVPWTTPVFLNAWLA
                     TAGDVRAVLVQFIIFALGVLLYIPFIKVNDKVVEQEMEG"
     gene            complement(48253..49662)
                     /locus_tag="ACL8AS_000781"
     CDS             complement(48253..49662)
                     /locus_tag="ACL8AS_000781"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HGS1228674.1"
                     /translation="MKKKLVFPNLFWWGAASSGPQTEGQYGKVHENVMDYWFKTHPED
                     FFDNVGPLVASNFFHTYTEDFHLMKEIGVNSFRTSIQWSRLIKNLETGEPDPKGIAFY
                     NAIIEEAKKNQMDLVMNLHHFDLPVELLQKYGGWESKHVVELFVKFAKTAFTCFGDKV
                     HYWTTFNEPMVIPEAGYLYAFHYPNLKGKGKEAVQIIYNLNLASAKVIQLYRSLGLDG
                     KIGIILNLTPAYPRSNSPEDLEASRFTDDFFNKVFLNPAVKGTFPERLVKQLERDGVL
                     WSHTEKELQLMKSNTVDFLGVNYYHPKRVQAQANPEEYQTPWMPDQYFKEYEWPERRM
                     NPYRGWEIFPKAIYDIAMIVKEEYDNIPWFISENGMGVENEARFIGENGVIDDVYRIE
                     FYEEHLRWLHKAIEEGSHCFGYHAWTAFDCWSWNNAYKNRYGFISVDLETQKRTIKSS
                     GRWYRKVSDNNGFEVEIEE"
     gene            49820..50548
                     /locus_tag="ACL8AS_000782"
     CDS             49820..50548
                     /locus_tag="ACL8AS_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HGS1228675.1"
                     /translation="MSTKYLFIYNEIREKILCNKYTMNEQLPDEMTLAKQFACSRMTI
                     KKALDLLVSEGLIFRKRGQGTFVLSRGSSKRKLIVPERDIRGLTKISEDAHSTIDSRI
                     IHFKLEFANEFLAEKLQVALQSPVYNIYRLRIIDGKPYVLEQTYMSTDVIPGITEDIL
                     QKSIYNYIEGKLGLHIASATKILRASSSSENEQHYLQLLPTEPVFEVEQVAYLDNGTP
                     FEYSISRHRYDLFEFNSFALRHSS"
     gene            51007..51201
                     /locus_tag="ACL8AS_000783"
     CDS             51007..51201
                     /locus_tag="ACL8AS_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HGS1228676.1"
                     /translation="MKGKEYENRTVSFAISSKGEKMKVENISYRVDHRILFDNISFDT
                     SSSGVTLITGKNGTGKSTLL"
     gene            complement(51323..51489)
                     /locus_tag="ACL8AS_000784"
                     /pseudo
     CDS             complement(51323..51489)
                     /locus_tag="ACL8AS_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558122.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(51567..52877)
                     /locus_tag="ACL8AS_000785"
     CDS             complement(51567..52877)
                     /locus_tag="ACL8AS_000785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HGS1228677.1"
                     /translation="MIHLIMISAIALAIGIGYRTKINIGLLAIAFSYLIATTLMGLSP
                     KELLHFWPTSLFFTIFSVSLFYNVATTNGTLDVLAQHILYRTRTHPNALYMILYLMAT
                     LLSALGAGFFTTMAVCCPLAITLCQKADKHPLIGAQAVNWGASGGANLITSSSGIVFQ
                     GLFKQMGWEEQAFSLGNHIFIVSIIYPLIVLLLLSCYSHYSKGRTNSSLTIDQPPLLS
                     KVQRQTTLLMISSMVLVWLFPLLHLIFPNIAWIATYQKTFDIGFVSILMVCLALRLKL
                     GKQEAILAKVPWATIIMLCGMSLLMSLAVKSGLVTLIGHLMTTTIPHFWLPLFFCVIA
                     GVMSLFSSTLSVVAPALFPIIAIISAQNPQIDIHLLTTATVIGALSTNISPFSSAGSL
                     IQLSLPNIEERGLAFKKQIILGVPISLSLGLLTTWILILLASLS"
     gene            53114..53986
                     /gene="nadC"
                     /locus_tag="ACL8AS_000786"
     CDS             53114..53986
                     /gene="nadC"
                     /locus_tag="ACL8AS_000786"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004514 - nicotinate-nucleotide
                     diphosphorylase (carboxylating) activity [Evidence IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HGS1228678.1"
                     /translation="MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV
                     SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL
                     TCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGY
                     NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGA
                     DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK
                     SLDFSMKGLTYLDV"
BASE COUNT        16494 a         9591 c        11426 g        16602 t
ORIGIN      
        1 tttagcgggt gtagtttagt ggtaaaacta cagccttcca agctgttgtc gcgagttcga
       61 ttctcgtcac ccgctttgaa ctttgttctt tgtaccaagt ttttgacttg ggcgcgtagc
      121 tcaggtggtt agagcgcacg cctgataagc gtgaggtcgg tggttcgagt ccactcgtgc
      181 ccatagtgtt tagtccatta ctaggggatt ggaatattat ctgttcacta agaggacacg
      241 ggcttgttcc cgtataaact attttggagg attacccaag tccggctgaa gggaacggtc
      301 ttgaaaaccg tcaggcgtgt aaaagcgtgc gtgggttcga atcccacatc ctccttttat
      361 attaacgcgg gatggagcag ctcggtagct cgtcgggctc ataacccgaa ggtcgtaggt
      421 tcaaatcctg ctcccgcaat aaggctcggt agctcagttg gtagagcaat ggattgaagc
      481 tccatgtgtc ggcggttcga ttccgtctcg cgccatttat atattttgga agggtagcga
      541 agaggctaaa cgcggcggac tgtaaatccg ctccttcggg ttcgggggtt cgaatccctc
      601 cccttccatt ttacgggcat agtttaaagg tagaactaag gtctccaaaa ccttcagtgt
      661 gggttcaatt cctactgccc gtgttaatag aattatggcg ggtgtggtga agtggttaac
      721 acaccagatt gtggctctgg catgcgtggg ttcgatcccc atcactcgcc tattttatat
      781 tggggtatag ccaagcggta aggcaaggga ctttgactcc ctcatgcgtt ggttcgaatc
      841 cagctacccc agttactatt tgccggcgtg gcggaattgg cagacgcgct ggactcaaaa
      901 tccagtgtcc gcaaggacgt gccggttcga ccccggccgc cggtatagtt gaaaagacaa
      961 ggtttctaag ccttgtcttt ttgttatgtc ataagaaatt tcttggaatt gttactaata
     1021 attactaatt tcatataaaa gcacatgatt aaaagttata gaaagtgata tttttgggta
     1081 attgtatcat agcaaagaat aggtattgtt ttgctattcg ttacatctcc atcaataaaa
     1141 taatgacttt tactatcata gtaaatctta cccaggtatc ttctatcttt agctacttcc
     1201 caagaagcaa tatggcccga aataatagct ttatgaaatc taccagtggt aataggaaat
     1261 ttgtttgtaa atatctctga actcgttagt tctttccaaa gctttccggc ttcttcatca
     1321 atgccagcat gaacaaaaat ttgggtatca gtttcataat agcgtttatc cctatatcgt
     1381 tttttaaacc agtttataaa tggattgaat ttgatattat ttttaatttc atttctaaca
     1441 cctgtttcaa agttgttagc attcgattta aaaatatagt tcaattcctc tggagagaag
     1501 aagcttttta ttgtttctgg aaatgctgaa gcagtaggct tatctaaaat caaccaatca
     1561 taaaaccatt cttcatgatt ccctagaaga gtaataattt gattaggata aacttcctca
     1621 agttcgatta ttttggaaat gacttgaaaa gattgaagtc cattatcaag ataatctcct
     1681 agtaaaaata ggcgattatc tttatcgttt aaatttactt tattgagagc gtctctgaat
     1741 tcatccaagt atccatgtat atcagatatt gcgtataatt tagccatagc gtctcatcat
     1801 ttcttcatgt gagatagctt ttttgccaca ttcaacccat tttttataag cttcatcagc
     1861 gaccttaata tcatacatat cttcaatttt ctctataaca gcttgtctaa taaagtcagt
     1921 ctttgttgta ttattttctt caacaatagc atttaataaa gaatttaact cttgactaag
     1981 ttgaatagaa atttgtgtag taacaacatt attcatataa cagccaccta atagttattt
     2041 tagatacatt atactcctag tctaaaagtt tctcaataaa aaatttcact ttttatagtt
     2101 atttatttta ataaaattgt agtatctgca aggatgtgcc agttcgagac cgaccgccag
     2161 tatagtaata aagacaaagt ttataagcct tgtcttttgt tttctcttta taaaatttta
     2221 tagtttagtt actaactttt tttctttgct cttaaaaatc taatagcaga actgtatttc
     2281 ttatttctct ctaagtcttt ttcagtaatt aatggtagtc ttgttaaatc tgaattatgc
     2341 cgtaaatccg ccaactttac aactctagcg agttcatttt tctttactag attgagataa
     2401 gattgataat cttgtccttt tttctttgtg agtatatcga cggcttctat aatgtttttt
     2461 gaaaaacctt ccttttttag gtctagtagg gttagtgaag tatcttcaat tacatcatgt
     2521 agataggcga cagctttctc ttcatcagtt gcgacaaaac tagctactgt ttcagggtgt
     2581 ttaatgtagt caattcctgc tctatcaatt tgtccaaagt gtgctttttt agctacttca
     2641 tgtgctttta ttacttgtga tgtatccatg atttaattat aaactttcca tttataaaac
     2701 tcaattactt tatagtaaat catctagttt atcagctaaa tccttttgct tacttgggta
     2761 caagtgagag taggtatcaa tcgtggttgt tatagaagca tgtcctagtc gctcttttac
     2821 aactagataa tcttcccctt ggttaatcag cagggaagcg tgtgagtgcc taaaatcgtg
     2881 tatgcgtatc ttttttagtg tgctatcacg ttcaatgatt ttcttgtact gcttttcaat
     2941 agcatttttc gtaattgtga taggactatt ttgaaacact tgtaatgtta ggctattgtt
     3001 ggtaaattgc tctaatagat gtttttgtcg cttttcccaa tcttgtaatt cttggcttaa
     3061 ttttttattg ataacaattc ttcttgttcc tgctttagtt tttgttgtgc tgatatgagt
     3121 tactccttta ttaacataga cagatttcgt gatatgaatt gtattacttg aaaagtcgat
     3181 gtcttgccat gttagggcaa gagcttcccc aagtcttaat cctgtaaaga atagaacagt
     3241 aaagagtagt ttgatattgt attcttcggg ttcaaatagt gtcaaaaact tctgaaattc
     3301 tttgactgtc caaaattgca tttttgtttt ttcaattggc aactttttta tcaattttgc
     3361 tggattggag gagtaatagc cttttcgcaa accaacatca aaaatttttt tgagtaaaat
     3421 catgattttg ttaatagtat ttgtgcttaa cggtttatca gaatttttag ctactttttg
     3481 cctaagatgt tctctaaatt ggtagatgtc ttcataggtt agttttccga cattatcgac
     3541 catagaaaaa taatctttga tgtgtttgtt gtaattatta tcttgtgtat tgatatagct
     3601 tgcttttcga tgatttatgc tatcttcttc cttaagtagt tcatatagta tggagatagt
     3661 tattttagcc ccatagaagc gttcttttaa ctctacactt cgtaagtagt gttctgcttc
     3721 aatagcttct tttttcgtct tatagccctt tctgacaagt ctacgttgct ttagtgttat
     3781 tgggtcaaaa ccgttgctaa tatcaactac ccaattaccg tctttacctt ttctaattgc
     3841 catattttac tccttgaggg tactgttttg aacatcaaaa ccgagtaatt cggtagcaat
     3901 agtagcaggt atagtaccaa ttcgcttgtt ctgatagact gtaaagcctc gggttatcag
     3961 ttgtattccg tttcatatag tacgactgaa ctatcatagt taaaatcttc ataagtgtaa
     4021 aatttatctt catcaggctt tttcaagttg cgtgatgaaa aataggcttg ctttccgaag
     4081 ttttccaaca attcttgtcc aatacctttt tcaaaatact ttgtgacata tcgaccgcga
     4141 ttttctttgc tgtcaacgtc aactttattt gctccatgcc cccaaagttc taataattgc
     4201 ttatgtggaa tatagggaac actgaatagc aaaatatgac tatgccatgc tttacgtttt
     4261 tgcctctcta atactgctat atattttaat ttacttttct tggtattaaa aatgtgatag
     4321 ttaaagcgtt taatatagga aattatagag ttcctttgta gtaaacacct tagtttctcc
     4381 tttataattt ctgcaagcta tttcacgcaa ccaagggaaa gtcacgtagc ttttcccatt
     4441 tgtgacaagt atatacatat caccactcct taaaataata tttttttcac taaaaacata
     4501 gactattttt attagctata agatgagatt gataaacgat accccaaata ccaaaagaat
     4561 aatactatct ctataagggg agaaaaaact cccccttaat tatataatta tattcttaat
     4621 ccttctgtat tgcgcctgcc agagccttga ctaaataatt atacttaatc ctattcaacc
     4681 ctaatctata caaaacataa taatacatat cagtgccttt aggaatttct tttgaaatac
     4741 tttctatatt ttcttcatca acatttcgta ctaagctttt gtgattaatt ttaacatttt
     4801 ctataacatc atccgtaatt acattagacg tattaacatc aaagaagtat atccctgtct
     4861 tcccatctat aacatcatcc gcttttaaac tccccgttat aaaatctcgt gttctacata
     4921 gcgtgttcca tacatttaaa atatctattg tatatctcat catacatttt tttccactct
     4981 ttccttctgg atcagaatct cttaaagctt gacgtatttt tttacaatat tctttagtaa
     5041 ttgagtctga tgttttgaat tcgtacctca agccatgtaa gtctgggcaa aacttagaaa
     5101 tcattctaag cttccctcca tctataatgc tatctaaact gtatttttca gtctctaata
     5161 attttggcat ttctgctcct cctttatatt tttttaatat tagtttttat ttaatgttgt
     5221 caaataaata ataggtgacg ctcctatcaa aatattctcc ttccgattaa aaagtttaaa
     5281 agtctcgtta acacagacaa aggttgtatt tttataagct cttattatcg agcttataaa
     5341 tcatgcaaac aattttttat agtaggcaaa tgcgaccatt ttaataacat agctcatcct
     5401 tacctgcctt atcatatcat cacttttgaa taaaaattga tacttctcta attctgaaat
     5461 aatattatta tctaaatata atctaggtgt taacgtccca atttccatgt tttgcttaac
     5521 ttttgccaaa ttcatttgcc ttgcaatttc tcgccattct gaagtagtgt aattttttgt
     5581 ctcgttatag gctttttcaa tcacgcttga agaagatacc ttgaaaaaag ttgttatgga
     5641 aacagccccc aatagagaat cttttttttc taacttatta gtgatgattg attctaactc
     5701 ctctatatct tgttcattaa ttaaagcatc taattttttt tgaacctctt cttgtataca
     5761 ttctaaccaa tacttggttt cgtatgcaag tcttatattt atataagtac gactcattct
     5821 tatacctcca actgtctctg ttatatagac attttaacac agtattttct atttgtcaac
     5881 aatatttttg aatttaaatt ctatataatt aaattgcgac attctattaa aaatataata
     5941 aactagtaat aataaaacta aataaggaga tagaaaatgc tatattggat atcagtcaat
     6001 tatgaaatta ctgaagacga agactttgag accgtcaaaa cgagagtgat atcagatttt
     6061 gaaagctatt tgaagcttct aaatggcaag tttgaagaaa gtctcaagaa agttattaag
     6121 tcttttacct ttagtaaact cattggagaa aaactatgta atggtgaaga cctaaaaaat
     6181 ttaagtaaag aaataaggca tcaaatccaa gataggaatt cctaaaaaat tactaaaaac
     6241 taaaataatt attgttttta tagtataact aatttcttaa aacattgaat taatctgaat
     6301 tatgacgtaa gtctgctaat ttcactgctc tcaaaatcca gtgtccgcaa ggacgtgccg
     6361 gttcgacccc ggccgccggt atagtatagt gttaggaacg ttgttattct tcgttctttt
     6421 tttatattat ttttggtata attatagtta ttcaaatttt atttagatta agaaagtgta
     6481 gggtagtatg tcttgttcta tcgatttatt aaaacatcgg tatttgaaaa atattaaaga
     6541 aaatcctgaa ttgtttgtcg gaattgagtt ggagtatcct gttgcaagtt tagaagggga
     6601 tgctacagat gttgaagtta taaaggatct atttcattat ttagtttcta ctttggatct
     6661 caccgtagca aaggtagatg attttggcaa tctgatccag ttagtagatc cgataagtca
     6721 ggatgctatt ttatttgaag tttcctatac aacgattgag tttgcatttg gtaaggctga
     6781 aacgattcaa gaggtcgaaa atcgtttcaa taattatatg aatgtaattc agagaaagtt
     6841 agctgaatca aatcatgcta ttgttggctg tggtatccat cccaactggg ataaaaatga
     6901 gaattgtcca gtggcttatc cacgctatca gatgttgatg gattatttga atttgagtag
     6961 aaatattatt aaatcagatt tacatcattt ccctgaatat ggtactttta tctgtgggag
     7021 ccaggttcag ctggatattt caaaaaccaa ctacttacgg gtgattaatg cttttactca
     7081 aattgaagcg gctaaggctt atttatttgc aaactctgaa ttttcgggtg cggattggga
     7141 tacgaaaatt tcaagggata ttttctggga agaatctatg catggtatct atccagagaa
     7201 tgttggggtc aatgctagac tccttaatga tgaagctgat ttttttgact atctaaatca
     7261 ttctgcgatt tttactgcgg aacgtgatgg gcagacctat tatttttatc ctattcaggc
     7321 tggggactat ttggctacac ctgaaatcca agcatttgct ctgaatgggg atgaggttat
     7381 tatttccccc caagagaagg attttgaaac tcatcgtagt taccagtacc aagacttaac
     7441 gactcgagga acagttgagt ttcgtagtgt gtgtacacag ccacttgata ggacttttgc
     7501 ttctgcagct tttcacttgg gattattggt taatttagac aagttagaag cttacttaga
     7561 aacagcacct ttctttaaag tatttggtta tgattacaag tctttaagga gacaattttc
     7621 taagaaaaat cttacagatg aggaagaaac tacgattatt gaattttcca aagacttact
     7681 cctactagct gaggagggac tagtggtgag aaataaggaa gaaatgacct atttacagcc
     7741 tttgagagaa gaattgagcc tataatttct cttataaagg gagaattttc tgaaaaatca
     7801 tgatataatg gacgagacta tagataaagg atagagagta atgacattag tttatcaatc
     7861 aacgcgtgat gccaacaata cagtaactgc tagccaagca attttgcaag gtttggcgac
     7921 ggacggcggt ttgtttacac cggttactta tccaaaggta gatttggact ttgacaaatt
     7981 gaaagatact tcttaccagg aagttgctaa gctagttttg tcagcatttt tagatgactt
     8041 tacagctgag gagttggact actgtatcaa caatgcctac gatagcaaat ttgatactcc
     8101 agctattgca ccattagtga aattagatgg gcaatacaat ttggaacttt tccatggttc
     8161 aacgattgcc tttaaggata tggccttgtc tattttgcca tactttatga cgactgctgc
     8221 taagaaacat ggtttggaga acaagattgt tatcttgaca gcgacatctg gtgacacggg
     8281 gaaagctgct atggcggggt ttgcggatgt gcctggtact gagattatcg tcttttatcc
     8341 aaaggatggt gtcagcaaga ttcaagagtt acaaatgacc actcaaactg gcgacaatac
     8401 tcatgttatt gctattgatg gtaactttga cgatgcgcaa acaaatgtga agcacatgtt
     8461 taacgacgtg gctcttcgtg aaaaattgac taccaacaag ttgcaatttt catcagctaa
     8521 ctctatgaac attggtcgtc tggtgccaca aattgtttat tatgtttatg cttacgctca
     8581 attggttaag actggtgaaa ttgtagctgg tgaaaaggtt aacttcacag taccaacagg
     8641 aaactttgga aatatcttgg ctgcctttta tgccaaacaa attggtttgc cagttggtaa
     8701 attaatctgt gcttcaaatg acaacaatgt tttgacagac ttctttaaaa cacgtgtcta
     8761 tgacaaaaaa cgtgagttta aggtaacaac cagcccatct atggatatct tggtatcttc
     8821 aaacttggag cgcttgattt tccatctttt gggaaataat gctgaaaaga caactgaact
     8881 tatgaatgcc ttgaacacgc aaggacaata taagttgaca gactttgatg cagagatttt
     8941 ggacctcttt gcagctgaat atgcgactga ggaagaaacg gcagcagaga tcaagcgtgt
     9001 ttgtgagtta gattcttata tcgaggaccc tcatacagct gttgcttcag cagtttataa
     9061 aaaataccaa tcggccactg gagatgtaac taagacagtg attgcttcaa cagctagtcc
     9121 atacaagttc ccagtagttg cagtagaagc tgtaactgga aaagcaggtt taacagactt
     9181 tgaagccttg gctcaattac atgaaatctc aggcgttgca gtgccaccag cagttgatgg
     9241 gcttgaaata gctccaattc gtcacaagac aacagtggca gctgctgaca tgcaagcagc
     9301 ggttgaggct tatttaggac tttaagacag agggagcaaa ctcggttggg aaaccaactg
     9361 agtttctttt catcaggagg agagattgtt taagaaaaat aaagacattc ttaatattgc
     9421 attgccagct atgggtgaaa actttttgca gatgctaatg ggaatggtgg acagttattt
     9481 ggttgctcat ttaggattga tagctatttc aggggtttca gtagctggta atattatcac
     9541 catttatcag gcgattttca tcgctctggg agctgctatt tccagtgtta tttcaaaaag
     9601 catagggcag aaagaccagt cgaagttggc ctatcatgtg actgaggcgt tgaagattac
     9661 cttactatta agtttccttt taggattttt gtccatcttc gctgggaaag agatgatagg
     9721 acttttgggg acggagaggg atgtagctga gagtggtgga ctgtatctat ctttggtagg
     9781 cggatcgatt gttctcttag gtttaatgac tagtctagga gccttgattc gtgcaacgca
     9841 taatccacgt ctgcctctct atgttagttt tttatccaat gccttgaata ttcttttttc
     9901 aagtctagct atttttgttc tggatatggg gatagctggt gttgcttggg ggacaattgt
     9961 gtctcgtttg gttggtcttg tgattttgtg gtcacaatta aaactgcctt atgggaagcc
    10021 aacttttggt ttagataagg aactgttgac cttggcttta ccagcagctg gagagcgact
    10081 tatgatgagg gctggagatg tagtgatcat tgccttggtc gtttcttttg ggacggaggc
    10141 agttgctggg aatgcaatcg gagaagtctt gacccagttt aactatatgc ctgcctttgg
    10201 cgtcgctacg gcaacggtca tgctgttggc ccgagcagtt ggagaggatg attggaaaag
    10261 agttgctagt ttgagtaaac aaaccttttg gctttctctg ttcctcatgt tgcccctgtc
    10321 ctttagtata tatgtcttgg gtgtaccatt aactcatctc tatacgactg attctctagc
    10381 ggtggaggct agtgttctag tgacactgtt ttcactactt gggaccccta tgacgacagg
    10441 aacagtcatc tatacggcag tctggcaggg attaggaaat gcacgcctcc ctttttatgc
    10501 gacaagtata ggaatgtggt gtatccgcat tgggacagga tatctgatgg ggattgtgct
    10561 tggttggggc ttgcctggta tttgggcagg gtctctcttg gataatggtt ttcgctggtt
    10621 atttctacgc tatcgttacc agcgctatat gagcttgaaa ggataggaaa tgcaaaaaac
    10681 agcttttatt tgggatttag acgggacttt attggactct tacgaagcga ttttatcagg
    10741 gattgaggag acttttgctc agttttctat tccttatgat aaggagaagg tgagagagtt
    10801 tatcttcaag tattcggtgc aagatttgct tgtgcgggtg gcagaagata gaaatctgga
    10861 tgttgaggtg ctaaatcagg tgcgtgccca gagtctggct gagaagaatg ctcaggtagt
    10921 tttgatgcca ggtgcgcgtg aggtgctagc ttgggcagac gaatcaggaa ttcagcagtt
    10981 tatatatact cataagggga acaacgcttt taccattctc aaggacttgg gggtggaatc
    11041 ctattttaca gagattttaa ccagtcagag tggctttgtg cggaagccaa gtccagaagc
    11101 ggctacctat ctgctagata agtatcagtt gaattctgat aatacttatt atatagggga
    11161 tcggactctg gatgtggaat ttgcccagaa tagtgggatt caaagcatca actttttaga
    11221 gtctacttat gaagggaatc acaggattca agcgttagca gatatttccc gtatttttga
    11281 gactaagtga taaaaagatt gtgtcagttt tgtgacagag acctaacaaa ctatttcaag
    11341 taacctagtt tgttacaagg aatagacagt tctgttaaat aggcccgaga gggctttttt
    11401 tctacatttt ttgtgttatg atagacaggt actcatttga aaggaatttg aaagaatgaa
    11461 gaaaagaatg ttattagcgt caacagtagc cttgtcattt gccccagtat tggcaactca
    11521 agcagaagaa gttctttgga ctgcacgtag tgttgagcaa atccaaaacg atttgactaa
    11581 aacggacaac aaaacaagtt ataccgtaca gtatggtgat actttgagca ccattgcaga
    11641 agccttgggt gtagatgtca cagtgcttgc gaatctgaac aaaatcacta atatggactt
    11701 gattttccca gaaactgttt tgacaacgac tgtcaatgaa gcagaagaag taacagaagt
    11761 tgaaatccaa acacctcaag cagactctag tgaagaagtg acaactgcga cagcagattt
    11821 gaccactaat caagtgaccg ttgatgatca aactgttcag gttgcagacc tttctcaacc
    11881 aattgcagaa gttacaaaga cagtgattgc ttctgaagaa gtggcaccat ctacgggcac
    11941 ttctgtccca gaggagcaaa cgaccgaaac aactcgccca gttgaagaag caactcctca
    12001 ggaaacgact ccagctgaga agcaggaaac acaagcaagc cctcaagctg catcagcagt
    12061 ggaagtaact acaacaagtt cagaagcaaa agaagtagca tcatcaaatg gagctacagc
    12121 agcagtttct acttatcaac cagaagagac gaaagtaatt tcaacaactt acgaggctcc
    12181 agctgcgccc gattatgctg gacttgcagt agcaaaatct gaaaatgcag gtcttcaacc
    12241 acaaacagct gcctttaaag aagaaattgc taacttgttt ggcattacat cctttagtgg
    12301 ttatcgtcca ggagacagtg gagatcacgg aaaaggtttg gctatcgact ttatggtacc
    12361 agaacgttca gaattagggg ataagattgc ggaatatgct attcaaaaca tggccagccg
    12421 tggcattagt tacatcatct ggaaacaacg tttctatgct ccattcgata gcaaatatgg
    12481 gccagctaac acttggaatc caatgccaga ccgtggtagt gtgacagaaa atcactatga
    12541 ccacgttcac gtttcaatga atggataaac ccgacttggt aacatcattt tgacgaatga
    12601 gatctagctt tcgtgatagg aagcgattct cgttcgtttt ttctttgtca tactcttcga
    12661 aaatctcttc aaaccacgtc agttttatct gaaacctcaa agctgtcctt tgggcaacct
    12721 gcgactagct tcctagtttg ctctttgatt ttcattgagt atcaatttga atggaaaatg
    12781 gaaagttatt atcttgtaat aatccaagca acattcttgc aatctatttt atagtagatt
    12841 gaaactagaa tagtacataa ctgcttctaa aacattgtta gaaatcgatt tgactgtcct
    12901 gatcgatttg tcctgctctt atttcatttc actatacttt atattataat tgactggtca
    12961 actattgata aatcaataaa aagagagggg aagaaatgct agagattcaa gatttactgt
    13021 atcaactccg cttgtctgag caagcgagta cgcaattgtt tgaaaaaggc ttgggattag
    13081 tttgacacgg tatcagattt tactgttttt gctggagcat tctctttgta accaaatggc
    13141 ggttcaggag cgtttgaaaa ttgatcaggc tgctttgaca cggcatttca agattttgga
    13201 aacggaaggt ttggtggagc gtcatcgtaa tcctgaaaat cagcgggaag tgttggtaga
    13261 ggctgcgaag tatgccaagg agcagttagt ggtgaatccc cctctgcaac atatcaaggt
    13321 taaggaagag atggaaagta tcttaacaga gtttgagaga acagaactca gccgtttatt
    13381 aaataaattg gttttgggta ttgaaaatat agaaatttaa ggagaaatag atgtcaatta
    13441 ttttaacaac gatcgttgct ttggagcatt tttacatttt ttatttggaa agtattgcca
    13501 cgcaatcaga tgcgactagt cgtgtattta atatggaaaa ggaagaattg gctcatccgt
    13561 cagtaagttc attgttcaaa aatcaaggga tttataaggc tctgctagga gtctttctct
    13621 tgtatgtcat ttatttctca cagaatttag aaattgtgac tatttttgtc ttatttgtga
    13681 ttggtgctgc gacttacggc tctttaacag cggataaaaa aattattttg aaacaaggtg
    13741 gatcagctat tttggccttg attagtattt tactctttaa atacacttga aggtcgattc
    13801 taatctcgct aatccttttt aatccagaat aagggaaata tgttatactt gtttttaaga
    13861 aaaaagtctc attgaattgg ttttgaggag ttagaaatga aagtattagt gacaggtttt
    13921 gagccctttg gaggggaaaa gggcaatcca actttggaga ccattaaagg tttaccagct
    13981 gaaatccatg gtgctgaggt ccgctggcta gaggtgccga cagtttttca caaatctgct
    14041 caagtattgg aagaagagat gaatcgttat caacctgact ttgtcctttg tattgggcaa
    14101 gctggtggaa gaactagttt gacacctgaa cgagtggcca ttaatcaaga cgatgcacgt
    14161 acttctgata acgaagataa tcaaccgatt gaccgtccca ttcgcctaga tggtgcttcg
    14221 gcctacttta gtagtttgcc gattaaagcg atggttcaag ctataaaaaa agagggctta
    14281 ccggcctctg tttccaatac ggcagggact tttgtctgca gccatttgat gtatcaggct
    14341 ctctatttgg tagaaaagaa atttccatat gttaaggcag gttttatgca tattccttat
    14401 atgatggaac aggtggtgaa cagacagact actccagcta tgagtttagt ggatattcgg
    14461 cgagggatag aagcagcaat cggcgctatg atagaacatg gagatcagga actcaagttg
    14521 gtaggcggag aaactcattg atagaaaaaa gcttgagggg aaaaaccttc aagcttttgg
    14581 acgttttcga gccaatactg ctcggtaaaa cataatttta gtgcattgga tataaggtag
    14641 gagtgaaaaa ctagcaatgc caaaggtaat ccaattgagg aagtaccaag gaagaagctg
    14701 taaatctagg acaaagtgct ggaacttgta gcccttcata aaggaacggc tagtttttag
    14761 gattcgtctt ggtgggacct gtcctaggtc tagactataa cagagaagaa attccacctg
    14821 tgaataggca taatactgtg gaatatagag gatatttcct acaatgatca agatgagact
    14881 tgcaagaaag tagagtccaa agaccatgag gaaacgctcg gtttcaactg atgagagatc
    14941 tagacttgga aactcaggat gtagggtgac gaattttttg gctaaaaagc tactataaaa
    15001 gaggaggtga atcccaagta aattagggat actccataaa aagagataga aacgtttgag
    15061 aagtagggtc aaaaaggttt gagaaaagcg ctcctcatca aagagagcta ggctgttttt
    15121 tacagatggc tccgttttag aatctttcat gagtgtcagt gttgcataga cggaactggt
    15181 caaaagaata gtcccgataa aggagactag tagaggaaag aggtaggctt gaagtatttg
    15241 gccaagtatg ctgaaaaatg gctgttctaa aacagtcccg tggatccgag ataagggatt
    15301 aagaaaacta gataagatga ccagcatact gggaaggata tagaggagaa agagacgggg
    15361 ggtgtcagcc tgaaaatgtt ttgactcctg acgaattgtt tttaaatcaa tttttggata
    15421 gttcattctc ttattatacc atagttctta tacatagttc gtgacagttc ctactttttt
    15481 tgataaaatc atacagtgtg tccttgggca cactgtatga actgggactg tctttcccag
    15541 cttcggaggt aaaaaatgtc agattcacca atcaaatatc gtttgattaa gaaagaaaaa
    15601 cacacaggag ctcgtctagg agaaatcatc actccccacg gtacctttcc gacacctatg
    15661 tttatgccag ttgggacaca agccactgtc aaaactcagt cacctgaaga attgaaggag
    15721 atgggttcgg gaattatcct atcaaacacc tatcatctct ggcttcgccc tggagatgaa
    15781 ctcattgcac gcgctggtgg tctccacaag ttcatgaatt gggaccagcc tatcttgaca
    15841 gatagtggtg gttttcaggt ttattcttta gcagatagcc gtaatatcac agaagaagga
    15901 gtaaccttta aaaatcatct aaatggttct aagatgttcc tatccccaga aaaagccatc
    15961 tctattcaga ataatctggg ttcagacatc atgatgtcct ttgatgaatg tcctcagttt
    16021 tatcaacctt atgactacgt taagaaatcg atagagcgta ccagccgttg ggctgagcgt
    16081 ggtttgaagg ctcaccgtcg tccacatgac caaggtttgt ttggaattgt gcaaggtgca
    16141 ggatttgaag accttcgccg ccaatcagct catgatcttg tcagcatgga tttctcaggc
    16201 tactctatcg gtggtttggc agtgggagaa acccatgaag agatgaatgc ggtcttggac
    16261 tttacaactc aactgctgcc tgaaaataaa cctcgttatc tgatgggtgt gggagcgcca
    16321 gatagcttga tcgatggggt cattcgtggg gtggatatgt ttgactgtgt cttaccgact
    16381 cgaattgctc gtaacgggac ttgtatgacc agtcaaggac gtttggttgt gaaaaatgcc
    16441 cagtttgctg aggactttac gccactggat cctgagtgtg attgctatac atgtaataac
    16501 tatacacgcg cttaccttcg tcacctgctc aaggctgatg aaacctttgg gatccgcttg
    16561 actagctacc acaatcttta cttcttgctt aacctgatga agcaagtgcg acaagccatc
    16621 atggatgaca atctcttgga attccgtgag tattttgtgg aaaaatatgg ctataataag
    16681 tcaggacgta atttctaaaa tggaattgat ataagctaaa aatcctaagt tttctcttag
    16741 gatttttctt ctttttttga tagaataaag tgtacaatga aaggaagaat aaactcgtat
    16801 gcgcattaaa tggttttcct tggttaggat tacaggttta cttttggtac tcttgtatca
    16861 cttctttcag acgatctttc ctggaggatt tttcggggta gatgtctttt tcacattttc
    16921 aggtttcctg attacagctc tactcattga agaattttct aaaaaccatg agattgattt
    16981 gataggattt tttagaagac gcttttatcg gattgtgcca cctgtggttt tgatggtctt
    17041 ggtgaccatg ccttttactt tcttggttcg ccaagactat gttgctggaa ttggtggcca
    17101 gattgcgagc gtcttaggct ttatgaccaa cttctatgaa ctcctaacag gtgggagtta
    17161 tgaatctcag ttcattcctc atttgtttgt tcataattgg agtttggcag ttgaggttca
    17221 ctactatatt ctttggggat tggcagtttg gttcttatcc aaacaagcta aatcaaatgg
    17281 tcagttgaag gggatggtct ttctcttatc tgctgttgcc ttcttgatca gtttcttctc
    17341 catgtttatt ggtagttttc tagtgacctc ttattcctct gtttatttct ccagtttaac
    17401 tcatgtctat ccattctttt tgggaagtat gttagcaact attgtaggcg ttcgtcagac
    17461 gacttccctc gtcaagcagt tggataaaat ctgggattta cgaaagactt tggtagtttt
    17521 tggaggaggc tttggtttcc tagttctttt gactttcttt gtcaaattca cttatctttt
    17581 tgcctatctt atcggcttct tacttgccag tcttgcagct cttgccatga ttctggcggc
    17641 gcgtgtctta catgaaaaga cacatcatat acaggagccg aagattatca gctttttagc
    17701 ggatactagc tatgcggttt atcttttcca ttggcctttc tatatcattt tctcacagtt
    17761 gacatcaaat cttcttgctg tattactgac tctgatttgt tcttatggct ttgccagtct
    17821 gtcattttat gtattggaac cttggattgc aggcaagaac acacctattg tccaaaccct
    17881 tcgtcccctg ccttatattc acgcaattct tgcagcaggt acaggaatct tgaccatcat
    17941 tgtctgcacg gtgaccttgt tggcaccaca agtgggagcg tttgagacag acttgactgt
    18001 caatggcttg aagcaagctg caacaaatat tggccagacc aaggtgatgg cagaacgggc
    18061 agatgcaaac agtttgggaa ttgctgatgg cactatgtta attggtgact cagtggcttt
    18121 aagggcaaat acagcactac agacagctct tcctggagca cagattaacg cgcaggtcag
    18181 cgtaacaacc aagaccgcaa atgaaatcat gctaaataat agccagaata aatttttacc
    18241 taagacggtg gtcattgcga ctggggtaaa taatcctgag aattacaagg atgactggga
    18301 cagtatcgtg aaaaatcttc ctaagggaca ccatatgatt ttggtgactc cttatgaggg
    18361 agataagaca aaagagacct atgccatcgt tgagaaggct gctgcctata tgagagaatt
    18421 ggcagagaag acaccttaca ttacgatagc agattggaat caagttgcga aagagcatcc
    18481 agaaatttgg gcaggaacag accaggttca tttcgggagt gagagtagca ctatcgaagc
    18541 aggagcaaaa ttgtatgcag atacgattgc cacagctttg cagacagctc aagacaagcc
    18601 ggttaaatca aaataacttg tattaaaaaa gagaagagtt ggagaaatcc agctctttta
    18661 aaatatctcc aaaaaatagg tctataccat ttacaaataa aaaagaaagg tttataatgt
    18721 aattgacata ataaattgta gaatcaatct tttaaggagg ttaacattat gcctaactat
    18781 attaaagcgg atcagttttt ctacccacac ggagttcgtc gaggtggtta cttggaactt
    18841 gtggacggca agtttgggaa acatgtagag cagattcctg aaggggctga ggtgattgac
    18901 tatacaggtt atagcattgc cccaggtctt gtggatactc atattcatgg atatgcaggt
    18961 gtagatgtga tggacaacaa cattgaaggt acattgcata ctatgagtga aggacttctt
    19021 agtaccggtg ttaccagttt cttacccaca actttaacag ccacttatga gcaattgctt
    19081 gcagtcactg aaaatcttgg aaaccattat aaagaagcaa caggtgctaa gattcgtggg
    19141 atttattatg aaggtccata tttcacagaa acttttaagg gggcacaaaa tccaacttat
    19201 atgagagacc cgggtgttga ggagtttcat tcttggcaaa aagcggcaaa tggcttgctt
    19261 aataaaattg cccttgcacc agaacgtgat ggggtggaag actttgttcg tacagttacg
    19321 ggcgaaggtg tgacggttgc tcttggacat tcaaacgcga cttttgatga agccaaaaaa
    19381 gcagtcgatg ctggagcgag tgtttgggtg catgcctaca atggaatgcg tgggttgact
    19441 caccgtgaat tgggtatggt tggagccatg taccaattgc cacataccta tgcagagttg
    19501 atctgtgatg gtcaccacgt agatccaaag gcttgcgaaa ttcttatcaa acaaaaagga
    19561 acagaaaaca tcgctcttat cacagactgt atgacagctg ggggattgga agacggagat
    19621 tatatgttgg gagaattccc agttgtcgtt gcaaatggaa ctgcacgcct caaatcgaca
    19681 ggtaacttgg caggttctat cctcaaactc aaagatggtt tgaagaatgt ggtcgaatgg
    19741 ggaattgcga atccgcatga agcagtcatg atggccagct tcaacccagc taaatccgtt
    19801 cacatcgatg acgtctgtgg ccaaatccgt gaaggctacg acgctgactt catcgtatta
    19861 gataaagatt tggaattggt agcaacctac ctagatggcg taaaacgtta tcaagcataa
    19921 gagagaaagc agaagttaga gactaacttc tgctttttta tgcagggtac tttactggta
    19981 aataaaaagt taaaaaaatc acaaaaaaag cttgaagaaa caaagaaaaa ggcttacaat
    20041 tgaactataa atattacaaa taaaaaaacg gaggagtgct ttatgaaagc ctatacttat
    20101 gttaaaccag gacttgcttc ttttgttgat gtagacaaac cagttattcg caagccaaca
    20161 gacgctattg tgcgtattgt aaaaaccact atttgtggaa cagacctcca tattatcaaa
    20221 ggggatgttc ctacttgcca aagtggtacc attcttggcc acgaagggat tgggattgtt
    20281 gaagaagttg gggaaggagt ttccaacttc aaaaaaggtg acaaggtctt gatttcttgc
    20341 gtctgtgcct gtggtaaatg ctactactgt aaaaaaggaa tttatgctca ctgtgaagac
    20401 gaagggggct ggattttcgg tcacttgatt gatggtatgc aggctgaata tctacgtgtc
    20461 cctcatgcag ataatactct ttaccatact ccagaagact tgtcagatga agctttggtt
    20521 atgctgtcag acattctgcc tactggatat gaaattggtg tcttaaaagg gaaagtagaa
    20581 cctggttgca gcgtagccat tattggttca ggtccagttg gattggctgc tcttttaaca
    20641 gcccaattct attcaccagc taaattgatt atggtagacc tagacgataa ccgcttggaa
    20701 actgccctat cattcggtgc gactcataag gttaattctt cagaccctga aaaagccatt
    20761 aaagaaattt atgatttgac agatggtcgt ggtgtggatg tcgctatcga agctgttggt
    20821 attcctgcaa catttgattt ctgtcaaaag attatcggtg tagacggaac ggttgccaac
    20881 tgtggtgtgc atggtaaacc agttgaattc gatttagata aactttggat tcgcaacatc
    20941 aatgtaacaa ctggtttggt atctacaaat acgactccac aattgttgaa agcgcttgaa
    21001 agtcataaga ttgaaccaga aaaattggta actcactatt tcaaactcag tgaaattgaa
    21061 aaagcctacg aagtcttcag taaggcagca gaccaccatg ccattaaggt cattatcgaa
    21121 aacgatatct cagaagccta agtagtaaaa atatttttgt acataagtaa atagaaattc
    21181 agtcatccat cagatggctg gattttttat caaaaaatta agaaatgagc atatttcttt
    21241 ccttgtctgg cggaattggt tataatatac ggtacaaagg aatgaatgaa tatgtatcgt
    21301 gttatagaaa tgtacggaga ttttaaaccg tggtggttct tagaaggttg ggaagaagat
    21361 attgtagcaa gtagaaaatt tgaccagtat tatgatgctc tcaaatacta caaaacttgc
    21421 tggtttagat tggaacaaga atcccctctt tataaaagta gaagcgactt gatgaccatt
    21481 ttttgggacc cggaagacca acgctggtgt gatgaatgtg atgagtattt acaacaatac
    21541 cattctttgg ctcttttgca ggatgagcag gttatcccag acgaaaaact acgctcaggc
    21601 tatgaaaaac aaaccagtca ggaaaggaat cgttcttgcc gtatgaaatt aaaatagaga
    21661 aaagtaactt ttttggagtt gcttttttta tttttctaac gctttgcgaa tagtataggt
    21721 gaggaggtaa gtatggttca agaaattgca caagaaatca ttcgctcggc tcggaaaaaa
    21781 ggggcgcaag acatttattt tgtccccaag ttagacgcct atgagcttca tatgagggta
    21841 ggagacgagc gctgtaaaat tggtagctat gattttgaaa agtttgcagc cgttatcagt
    21901 cactttaagt ttgtggcggg tatgaatgtg ggagaaaaaa gacgtagtca actgggttcc
    21961 tgtgattatg cctatgacca gaagatggcg tctctacgtt tatctactgt aggcgattat
    22021 cgggggcatg agagtttggt tatccgtttg ttgcacgatg aggagcagga cttgcatttt
    22081 tggtttcagg atattgaaga attaggcaag cagtacaggc aacggggact ctatcttttt
    22141 gctggtccgg ttgggagtgg taagacgacc ttgatgcatg aattgtccaa gtcactcttt
    22201 aaaggacagc aagttatgtc catcgaagat cctgtcgaaa tcaagcagga cgacatgctt
    22261 cagttgcagt tgaacgaagc aatcggtcta acctatgaaa atctaatcaa actttccttg
    22321 cgtcatcgac cagatctctt gattatcgga gaaattcgtg acatcgagac ggcgcgtgca
    22381 gtggtcagag ctagtttgac aggtgcgaca gtcttttcaa ccattcacgc caagagtatc
    22441 cgaggtgttt atgagcgtct gctggagttg ggtgtgagtg aagaagaatt ggcagttgtt
    22501 ctgcaaggag tctgctacca gagattaatc gggggaggag gaatcgttga ctttgcaaac
    22561 agagattatc aagaacacca agcagccaag tggaatgagc aaattgacca gcttcttaaa
    22621 gatggacata tcacaagtct tcaggctgag acggaaaaaa ttagctacag ctaagcaaaa
    22681 aaatatcatc accctattta acaatctctt ttctagcggt tttcatctgg tggagactat
    22741 ctccttttta gataggagtt ccttgttgga caagcagtgt gtgacccaga tgcgtacagg
    22801 cttgtctcag gggaaatcat tctcagaaat gatggaaagt ttgggatgtt caagtaccat
    22861 tgtcactcag ttatctctag ctgaagttca tggcaatctt cacctgagtt tgggaaagat
    22921 agaagaatat ctagacaatc tggccaaggt caagaaaaag ttaattgaag tagcgaccta
    22981 tcctttgatt ttgctgggtt ttcttctctt aattatgctg gggctacgga attacctgct
    23041 cccacaactg gatagtagca atattgccac ccgaattatc ggtaatctgc cacaaatttt
    23101 tctagtcatg gtagggcttg tttccgtgct tgccctttta gcactaactt tttataaaag
    23161 aagttctaag atgagtgtct tttctatctt agcacgcctt ccctttattg gaatctttgt
    23221 gcagacctac ttgacagcct attatgcacg tgaatggggg aatatgattt cacagggaat
    23281 ggagctgacg cagatttttc aaatgatgca ggaacaaggt tcccagctct ttaaagaaat
    23341 cggtcaagat ctggctcaaa ccctgaaaaa tggccgtgaa ttttctcaga cgataggaac
    23401 ctatcctttc tttaggaagg aattgagtct catcatagag tatggggaag ttaagtccaa
    23461 gctgggtagt gagttggaaa tctatgctga aaaaacttgg gaagcctttt ttacccgagt
    23521 caaccgcacc atgaatttgg tgcagccact ggtttttatc tttgtggcac tgattatcgt
    23581 tttactttat gcggcaatgc tcatgcccat gtatcaaaat atggaggtaa atttttaaaa
    23641 tgaaaaaaat gatgacattc ttgaaaaaag ctaaggttaa agcttttaca ttggtggaga
    23701 tgttggtggt cttgctgatt atcagcgtgc ttttcttgct ctttgtacct aatctgacca
    23761 agcaaaaaga agcagtcaat gacaaaggaa aagcagctgt tgttaaggtg gtggaaagcc
    23821 aggcagaact ttatagcttg gaaaagaatg aagatgctag cctaagcaag ttaaaagaag
    23881 atggacgcat cacggaagaa caggctaaag cttataaaga atacaatgat aaaaatgtgg
    23941 gagcaaatcg taaagtcaat gattaaggcc tttaccatgc tggaaagtct cttggttttg
    24001 ggtcttgtga gtatccttgc cttgggcttg tccggctctg ttcagtccac ttttgcggcg
    24061 gtagaggaac agattttctt tatggagttt gaagaactct atcgggaaac ccaaaaacgc
    24121 agtgtagcca gtcagcaaaa gactaatcta aatttagatg ggcagacgct tagcaatggc
    24181 agtcaaaagt tgacagttcc taaaggaatt caggcaccat caggccaaag tattacattt
    24241 gaccgagctg ggggcaattc gtccctggct aaggttgaat ttcagaccag taaaggagcg
    24301 attcgctatc aattatatct aggaaatgga aaaattaaac gcattaagga aacaaaaaat
    24361 tagggcagtg attttactgg aagcagtagt cgctctagct atctttgcca gcattgcgac
    24421 cctccttttg ggacaaattc aaaaaaatag gcaagaggaa gcaaaaatct tgcaaaagga
    24481 agaagtcttg agggtagcta agatggccct gcagacgggg caaaatcagg taagcatcaa
    24541 cggagttgag attcaggtat tttctagtga aaaaggattg gaggtctacc atggttcaga
    24601 acagttgttg gcaatcaaag agccataagg tcaaggcttt taccttgtta gaatccctac
    24661 ttgccctcat tgtcatcagt gggggattac tcctttttca aactatgagt cagctcctca
    24721 tttcagaagt tcgctaccag caacaaagcg agcaaaagga gtggctcttg tttgtggacc
    24781 aacttgaggc agaattagac cgttcgcagt tcgaaaaagt agaaggcaat cgcctataca
    24841 tgaagcaaga tggcaaggac atcgccatcg gtaagtcaaa gtcagacgat tttcgtaaaa
    24901 cgaatgctcg tggtcgaggt tatcagccta tggtttatgg cctcaaatca gctcagatta
    24961 cagaggacaa tcaactggtt cattttcgtt tccagtttca aaaaggctta gaaagggagt
    25021 tcatctatcg tgtggaaaaa gaaaaaagtt aaggcaggtg ttctcctcta cgcagtcacc
    25081 atagcagcca tctttagtct tttgttgcaa ttttatttga accgacaagt cgcccactat
    25141 caagactatg ctttgaataa agaaaaattg gttgcttttg ctatggctaa acgaaccaaa
    25201 gataaggttg agcaagaaag tggggaacag gtttttaatc taggtcaggt aagctatcaa
    25261 aacaagaaaa ctggcttagt gacgagggtt cgtacggata agagccaata tgagtttctg
    25321 tttccttcag tcaaaatcaa agaagagaaa agagataaaa aggaagaggt agcgaccgat
    25381 tcaagcgaaa aagtggagaa gaaaaaatca gaagagaagc ctgaaaagaa agagaattcc
    25441 tagtcaattc aactataatg cgttgaatcc agaatagtcc actgtagttt ctagaaaatt
    25501 gctggaaatg gatgttaagc tccaattcat ttgtttatat cttatttcag tttactatac
    25561 tttgtgctaa attaaagata tgaaacatga ttttaaccac aaagcagaaa ctttcgattt
    25621 ccctaaaaat atcttcctcg caaacttggt atgtcaagca gccgagaaac agattgatct
    25681 tctatcatac aaagaaattt tagatttcgg tggtggcacg ggtctattag ccttgcccct
    25741 aacccctagc caagcaggct aagtcagtca ctcttgtaga catttctgag aaaatgttgg
    25801 agcaagctcg tttgaaagtg gagcagcaag caatcaagaa tatccagttt ttggagcaag
    25861 atttaccgaa aaatcccttg gagaaagagt ttgattgcct tgctgttagt cgggttcttc
    25921 atcatatgcc tgatttggat gcggctctct cactgtttca tcaacatttg aaggaagatg
    25981 ggaaactcat cattgctgat tttaccaaga cagaagctaa tcatcatgga tttgatttag
    26041 ctgaactgga aaacaagcta attgagcatg gtttttcatc tgtgcatagt cagattctct
    26101 atagcgctga agacctgttt caaggaaatc actcagaatt ctttttaata gtagcccaaa
    26161 aatcactcgc ctagtcaggg agtgattttt ctataagaat ggaaaaaaga agggaaattt
    26221 gataagatag gaatatggat tttgaaaaaa ttgaacaagc ttatacctat ttactagaga
    26281 atgtccaagt catccaaagt gatttggcga ccaactttta tgacgccttg gtggagcaaa
    26341 acagcatcta tctggatggt gagactgagc tagaacaggt caaagacaac aatcagaccc
    26401 ttaagcgttt agcactacgc aaagaagaat ggctcaagac ctaccagttt ctcttgatga
    26461 aggctgggca aacagaaccc ttgcaggcca atcaccagtt tacaccggat gctattgctt
    26521 tacttttggt gtttattgtg gaagagctgt ttaaagagga ggaaattact atcctcgaaa
    26581 tgggttctgg gatgggaatt ttgggcgcta ctttcttgac ctcgcttact aaaaaggtgg
    26641 attatttggg aatggaagtg gatgatttgc tgattgattt ggcagctagc atggcagatg
    26701 taattggttt gcaggctggc tttgtccaag gagatgccgt tcgtccacaa atgctcaaag
    26761 aaagtgatgt ggtcatcagc gacttgcctg ttggctatta tcctgatgat gccgttgcgt
    26821 cgcgccatca agttgcttct agtcaagaac atacttacac ccatcacttg ctcatggaac
    26881 aaggacttaa gtacctcaag tcagacggat acgctatttt tctagctccg agtgatttgt
    26941 tgaccagtcc tcaaagtaat ttgttgaaag tctggttgaa agaggaggca agtctggttg
    27001 ctatgattag tttacctgaa aatctctttg ctaatgctaa acaatctaag actattttta
    27061 tcctacagaa gaaaagtgaa atagcagtag agccttttgt ttatccactt gctagcttgc
    27121 aagatgcaag tgttttaatg aaatttaaag aaaattttca aaaatggact caaggtactg
    27181 aaatataaaa tagattttgt tataatagtt gaaaacgctt aaaaaggggt atcatgttat
    27241 gacaaaaaca attgcaatca atgcaggaag ttcaagtttg aaatggcaat tatacttaat
    27301 gccagaagaa aaagtattgg cgaaaggttt gattgaacgt atcggtttga aagattcaat
    27361 ttcaactgta aaatttgacg gccgttctga acaacaaatt ttggatattg aaaatcatac
    27421 acaagctgtt aaaattttat tggatgactt gattcgtttc gatattatca aggcttatga
    27481 cgagattaca ggtgttggac atcgtgttgt tgctggtgga gaatatttca aagaatcaac
    27541 agttgttgag ggagatgttt tagaaaaagt tgaagagttg agtttgttgg ctcctctaca
    27601 caacccggca aatgcagcag gtgttcgtgc cttcaaggaa ttgttgccag acattaccag
    27661 tgtagttgtt tttgatactt ccttccacac aagtatgcca gagaaagctt atcgctaccc
    27721 tctaccaaca aaatattaca cagaaaacaa ggttcgtaaa tacggtgctc atggtacaag
    27781 tcaccagttt gtagcaggag aagctgcaaa actcttggga cgtccattag aagacttgaa
    27841 gttaattacc tgtcatattg gtaacggagg ctcaattaca gctgtgaaag ccggcaaatc
    27901 tgtagacact tctatggggt tcactcctct tggtggtatt atgatgggaa cgcgtacagg
    27961 ggatattgat ccagctatca ttccttattt aatgcaatat acagaggatt ttaacacacc
    28021 agaagatatc agtcgtgttc ttaaccgtga atcaggtctt ttgggagttt ctgctaattc
    28081 tagcgatatg cgcgatatag aagcagctgt agcagaaggg aatcacgagg ctagcttggc
    28141 ttatgaaatg tatgttgacc gtatccaaaa acatatcggt cagtaccttg cagtgctaaa
    28201 tggagcagat gccattgttt tcacagcagg tgtcggtgaa aatgcagaga gtttccgtcg
    28261 tgatgtaatc tcagggattt cgtggtttgg ttgtgatgtt gatgatgaaa agaatgtctt
    28321 tggcgttaca ggagacatct caacagaggc agctaaaatc cgtgtcttgg ttattccaac
    28381 agatgaagaa ttagtcattg cccgtgacgt tgaacgcttg aaaaaataag tgaaactaaa
    28441 aaaatattca atacaaggag ttgggaaagt tatttttcca gcttcttttt ctgatgaaat
    28501 tgtccaaaac cttgctatga ttggcttttt tgaaaaatat ggtataatag tagtaattta
    28561 atagatggag ttgagttttg aagaaaaact ttcgtgtaaa aagagagaaa gattttaagg
    28621 cgattttcaa ggaggggaca agttttgcta atcgcaaatt tgtggtctac caattagaaa
    28681 accagaaaaa ccattttcga gtaggtctat cagttagcaa aaaactgggg aatgccgtca
    28741 ctagaaatca aattaagcga cggattcggc atattatcca gaatgcaaaa gggagtctgg
    28801 tagaagatgt cgactttgtt gtcattgctc gaaaaggagt cgaaaccttg ggatacgcag
    28861 agatggagaa aaatctactc catgtattaa aattatcaaa gatttaccgg gaaggaaatg
    28921 ggagtgaaaa agaaactaaa gttgactagt ttgctaggac tgtctctgtt aatcatgaca
    28981 gcctgtgcga ctaatggggt aactagcgat attacagccg aatcggctga tttttggagt
    29041 aaattggttt acttctttgc ggaaattatt cgctttttat cgtttgatat tagtatcgga
    29101 gtggggatta ttctctttac ggtcttgatt cgtacagtcc tcttgccagt ctttcaggtg
    29161 caaatggtgg cttctaggaa aatgcaggaa gctcagccac gcattaaggc gcttcgagaa
    29221 caatatccag gtcgagatat ggaaagcaga accaaactag agcaggaaat gcgtaaagta
    29281 tttaaagaaa tgggtgtcag acagtcagac tctctttggc cgattttgat tcagatgccg
    29341 gttattttgg ccctgttcca agccctatca agagttgact ttttaaagac aggtcatttc
    29401 ttatggatta accttggtag tgtggataca acccttgttc ttccgatttt agcagcagta
    29461 ttcacctttt taagtacttg gttgtccaac aaagctttgt ctgagcgaaa tggcgctacg
    29521 actgcgatga tgtatgggat tccagtcttg atttttatct ttgcagttta tgcgccaggt
    29581 ggagtcgccc tatactggac agtgtctaat gcttatcaag tcttgcaaac ctatttcttg
    29641 aataatccat tcaagattat cgcagagcgc gaggccgtag tacaggcaca aaaagatttg
    29701 gaaaatagaa aaagaaaagc taagaaaaag gctcagaaaa cgaaataaat aaggaggaat
    29761 ctggtaatgg tagtatttac aggttcaact gttgaagaag caatccagaa aggattgaaa
    29821 gaattagata ttccaagaat gaaggctcat atcaaagtca tttctaggga gaaaaaaggc
    29881 tttcttggtc tatttggtaa aaaaccagcc caagtggata ttgaagcgat tagtgaaacg
    29941 actgttgtca aagcaaatca acaggtagta aaaggcgttc cgaaaaaaat caatgatttg
    30001 aacgagcctg tgaagacggt tagtgaagaa accgttgacc ttggtcatgt ggttgatgct
    30061 attaaaaaaa tagaggaaga aggtcaaggt atttctgatg aagtcaaggc tgaaatctta
    30121 aaacatgaaa gacatgccag cactatctta gaagaaactg gtcacattga gattttaaat
    30181 gaacttcaaa tcgaggaagc gatgagggaa gaagcaggcg ctgatgacct tgaaactgag
    30241 caagaccaag ctgaaagtca agaactagaa gacttgggct tgaaagttga aacgaacttt
    30301 gatattgaac aagtagctac ggaagtaatg gcttatgttc aaacgattat tgatgacatg
    30361 gatgttgagg ctacactttc aaatgattat aaccgtcgta gcatcaattt gcaaattgat
    30421 actaacgaac caggtcgtat tatcggctac catggtaaag tcttgaaggc cttgcaactg
    30481 ttggctcaaa attatcttta caactgctat tcaagaacct tctatatcac tattaatgtc
    30541 aatgattatg ttgaacaccg tgcagaagtc ttgcagacct atgcgcaaaa attggcgatt
    30601 cgtgttttag aagaaggacg tagtcatcaa acagatccaa tgtcgaatag tgaacgcaag
    30661 attatccacc gtattatttc acgtatggat ggcgtgacca gttactctga aggtgatgag
    30721 ccaaatcgct atgtcgttgt agatacagaa taagtaaaat cagggttgac ctgatttttt
    30781 gctagctaga ggaggttaaa ctgatgttga ataagataag agactattta gactttgctg
    30841 gtttgcagta ccgtaatcct gataaagcgg gagcagagcg agagaagatg ctggcattcc
    30901 gccacaaagg acaagaggct cgaaaggctt ttacagaact ggccaaagcc tttcaagcaa
    30961 gccatccaga atggcaactc caacagacta gtcagtggat gaatcaggcc cagcgtttga
    31021 gaccacattt ttgggtttat ctacagagag acggacaagt gacagaacct atgatagcct
    31081 tgcgtttgta tggaaatcct tctgattttg gtatttcctt agaagtcagt ttcatcgaac
    31141 gtaagaagga tgagcaaaca ctgggcaagc aggccaaagt tttagaaatt ccaaccgtta
    31201 aagggattta ttatctaacc tactctaatg gtcaaagtca acggtgggag gcgaatgaag
    31261 aaaagcgtcg tactttacgc gagaaggtga gaagtcaaga agttcgaaaa gttttagtga
    31321 aggtagatgt tcctatgaca gaaaattcgt ctgaagaaga aatcgtagaa ggcttattga
    31381 agtcttattc taaaattctt ccctattatc aggtgactag aggataacgt gtcagtcaat
    31441 tattataaga ttacagtcca agagtgaaca gtccgctgtg taattcttgg tctttttgtt
    31501 tgcgctttcg cattatataa taaacttaca aaaacaattc aaaaggagaa caattatgga
    31561 agtcgtttca aatgttctaa attggttttc tagcaatatt ttgcagaatc ccgcattttt
    31621 cgtaggttta ttggtgttga taggatatgc acttttgaaa aaacctgccc atgacgtttt
    31681 ttcagggttt gttaaagcaa cagtagggta tatgttgctt aacgtgggtg ctggtggttt
    31741 ggttacaacc tttcgtccaa tcttagcagc tcttaactac aaattccaaa ttggtgcagc
    31801 ggttatcgac ccttactttg gacttgctgc agcaaacaac aaaattgcag cagagtttcc
    31861 agattttgtt ggaactgcaa ctacagctct attgattggt tttggaataa atatcttgct
    31921 cgtagctctt cgaaagatta cgaaggtaag aaccctcttt attactggtc acatcatggt
    31981 acaacaagct gcaacagtat ctcttatggt tctattctta gtaccacaat tgcgcaatgc
    32041 ttacggtaca gcagcgattg gtatcatctg tggactttac tgggcagtta gttcaaatat
    32101 gactgttgag gcaactcaac gcttgactgg tggtggcgga tttgcgattg gtcaccaaca
    32161 gcaatttgca atctggtttg tagataaagt agcaggacgc tttggtaaga aagaagaaag
    32221 tttagacaat cttaaattac ctaagttcct ctcaatcttc cacgatacag ttgttgcatc
    32281 tgctaccttg atgctcgtat tcttcggagc cattctttta atcttgggtc cagacattat
    32341 gtctaataaa gaagtcatca cttcaggaac tctattcaat cctgctaaac aagatttctt
    32401 tatgtacatt atccaaacag cctttacctt ctcagtttac ttgttcgttt tgatgcaagg
    32461 tgtccgaatg ttcgtatctg agttgacaaa cgccttccaa ggtatttcaa acaaattgtt
    32521 gccaggttca ttcccagcgg ttgacgttgc agcttcttat ggatttggtt ctccaaatgc
    32581 tgtcttgtca ggatttacct ttggtttgat tggtcaattg attacaattg tcttgctcat
    32641 cgtctttaaa aatccgattc ttattattac aggatttgta ccagtgttct ttgacaatgc
    32701 agccattgcg gtctacgctg ataaacgcgg cggatggaaa gcggctgtta tcctttcctt
    32761 tatatcaggt gtccttcaag ttgctctagg agctctttgt gtggcccttc tcgatttggc
    32821 atcttatggt ggctaccatg gaaatatcga ctttgaattc ccatggcttg gatttggata
    32881 tatcttcaaa taccttggta ttgttggtta tgtacttgtg tgtctcttct tgcttgttat
    32941 tcctcaactt caatttgcca aagcaaaaga taaagagaaa tattacaacg gtgaagttca
    33001 agaagaagct tagtatctag aaaaggagaa ataaaatggt taaagtatta gcagcgtgcg
    33061 gaaatggaat gggttcatca atggttatca agatgaaggt tgaaaatgct ctccgtaagc
    33121 ttaatcaaac agattttaca gtcaattcat gcagtgtcgg tgaagctaaa ggtttagcag
    33181 taggatatga catcgtaatc gcttctcttc atttgattca agaattggaa gggcgaacta
    33241 atgggaagtt aattgggctt gataacttga tggatgataa agaaatcacc gaaaaactca
    33301 gtcaagcact acagtaaaag gttggagggg gctggacaga aactgagagt tatcgtttct
    33361 gtccttctcc ctctttaaat aaaggaggca gatatgaatt taaaacaagc tttaattgac
    33421 aatgactcga tccgactagg tttagaggct aacgattgga aagaagcagt caaggtagca
    33481 gtagatccct tgattgaaag tggggcaatt ttgccagagt attacgatgc tatcattgaa
    33541 tcgactgaag agtatgggcc ttactatatc ttgatgccag gtatggctat gccccacgct
    33601 agacctgaag ctggtgtgca aagtgatgcc ttttcattaa ttaccttaca aaatcctgtt
    33661 gtattttcag atgggaaaga ggtatctgtt ttgttggcac tagcagcaac aagttcaaaa
    33721 attcacacaa gtgtagccat tccacaaatt attgccctgt ttgaattaga agattctatt
    33781 gcacgtttac aggcttgcca gactaaagaa gatgtcttgg ctatgattga agaatctaag
    33841 gatagccctt atctcgaagg attggatttg gaaagttaga aagaggaata aagaaatgac
    33901 aaaaagaata cctaatttac aagttgcatt agaccattca gacttgcaag gagcgattaa
    33961 agcagctgtt tctgttggtc aggaagtaga tattatcgaa gctggaactg tttgcttgct
    34021 tcaagttgga agtgaactgg ctgaagtctt gcgtagcctt ttcccagata agattattgt
    34081 ggcagacaca aaatgtgctg atgctggtgg aacagttgct aaaaataatg cggttcgtgg
    34141 agcagactgg atgacttgta tctgttgtgc aaccatccct actatggaag cagctctaaa
    34201 ggctatcaag actgaacgag gagaacgagg cgaaatccag atcgagcttt atggcgattg
    34261 gacttttgaa caagctcagc tttggctaga tgcaggtatc tcacaagcta tttatcacca
    34321 atctcgtgat gctcttcttg ctggtgaaac ttggggtgaa aaagacctta ataaggttaa
    34381 aaaactcatt gacatgggct tccgtgtatc tgtaacaggt ggtctagatg tagatactct
    34441 caaactcttt gaaggtgttg atgtctttac ctttatcgca ggtcgtggaa ttacagaggc
    34501 tgtggatcca gcaggagcag cgcgtgcctt caaggatgaa atcaaacgaa tttgggggta
    34561 aatcatggta cgtccaattg gaatttatga aaaggcaacc ccaacacact ttacttggct
    34621 agaacgttta aattttgcca aggagttagg ctttgatttt atcgagatgt ctattgacga
    34681 acgtgacgag cgtttagcaa gacttgactg gagtaaggaa gaacgcttgg aagttgtcaa
    34741 agaaatctat gaaactggtg ttcgtattcc ttctatctgt ttttcaggcc atcgtcgcta
    34801 cccattggga tcaaaagatt cagttctaga ggaaaaatct ctagaactca tgaaaaaatg
    34861 tatcgaatta gctcaagact tgggagttcg tacgattcaa ttagctggtt acgatgttta
    34921 ctatgaggaa aagtcacccc agacacgcca acgttttatc aaaaatttga gaaaagcctg
    34981 tgactgggct gaagaagctc aggtggtact tgctattgaa attatggatg atcctttcat
    35041 caatagcatc gaaaaatatt tggctataga aaaagagatt gactctccct tcctctttgt
    35101 atatccagat attggtaatg tgtctgcatg gcataatgat atctatagtg agttttatct
    35161 tggtcatcat gccatcgcag ctctccatct caaggatact tatgcagtga cagaaagttc
    35221 aaagggccag ttccgagatg taccttttgg gcaaggttgt gtcaaatggg aagaagcttt
    35281 cgatatttta aaggaaacca attataatgg acctttccta atcgaaatgt ggtctgaaaa
    35341 ttgtgaaaca gtagaagaaa cacgcgcagc cattcaagag gcgcaagctt ttctctatcc
    35401 actcattaag aaagcaggtt tgatgtaaga tgaatcaagt aatcaatgct atgcgtaaac
    35461 gagtctgtga tgccaatcaa tcattgccaa aacatggact tgtcaaattt acctggggga
    35521 atgtatctga agtcaatcgc gaactcggtg tcattgttat caaaccatca ggcgtggatt
    35581 atgacgaatt gacacctgaa aacatggtag tgactgatct agatggtaag atcctagaag
    35641 gggatttaag accatcttcc gacctcccaa ctcatgtgca attatataag gcttggtcag
    35701 aaattggtag tgtggttcac acccattcga cagaagctgt tgcttgggct caggcaggtc
    35761 gtgatattcc tttctacgga acaacccatg cagattattt ctacggttca atcccttgcg
    35821 cccgtagttt gaccaaggac gaagtagaag tggcctatga aaaagatact ggcctggtta
    35881 tcgtagaaga gtttgaacat cgcggactta acccggttga agtaccagga attgttgtac
    35941 gcaatcacgg tccattcacc tggggcaaaa atccagagaa tgctgtttat cactctgtcg
    36001 tactagagga agtatcaaag atgaatcgct ttacagaaca aatcaatcca agagttgaac
    36061 ctgctcccca gtacatacta gaaaaacact accaacgtaa acatggacca aatgcttatt
    36121 atggtcaaaa gtaagaacga tgaaggagga gaaaaagata aatttagctc ctctttttac
    36181 atttgatttt tattgagagt aaagttggag ttgaagtaat tttgaaagat tttttagaaa
    36241 tagcgcttga tatatatata tggtaaaata aaaagaattg ctgtgatatc aatagatttg
    36301 ggggattttt taatatggta ctggataagg caagttgtga tttacttcaa tatttgatgg
    36361 atcaagaaac gtccaaaacg attatggcga tttcgaaaga tttgaaagag tcaagaagga
    36421 aaatttatta tcacattgac aaaatcaatg ctgctctggg tgacgaggcg cttcacatca
    36481 ttagtattcc acgaattggt attcacttaa cggaagagca gagagatgct tgttgtaaac
    36541 tattatcgga agtagattcg tacgattata tcatgagtgc gcatgaacgt atgatgataa
    36601 tgttattatg gataggtatt tctaaagaac gtattacgat tgaaaaattg atagagttaa
    36661 cagaggtatc taggaatact gttctcaatg atttgaatag tattcgttat caactaactt
    36721 tggaacaata tcaggtgacc ttgcaagtga gcaagtcaca gggataccac cttcatgccc
    36781 accctcttaa taaaattcag tatcttcaat cgcttctata tcatattttt atggaagaaa
    36841 atgccacttt tgtatctatt ttagaagata agatgaaaga gaggttagat gatgagtgtt
    36901 tgctttctgt tgaaatgaac caatttttta aggaacaggt tcctttagtt gaacaagatt
    36961 tagggaagaa aataaaccat catgaaataa cttttatgtt gcaggttcta ccttatttgc
    37021 tgttaagctg tcataatgtt gaacagtatc aagaaagaca tcaggatata gagaaagaat
    37081 tttctttgat aagaaaaaga atagagtatc aggtgtctaa gaaattagga gaacggttgt
    37141 ttcaaaagtt tgaaatttct ttgtcaggac ttgaagtttc tcttgtagct gttctcctcc
    37201 tctcctatcg taaagatttg gatattcatg cagaaagtga tgattttcgg caattaaaac
    37261 ttgctttaga agaatttatc tggtattttg aatcacaaat ccgaatggag attgagaaca
    37321 aggatgattt gttacgaaat ttgatgatcc actgtaaagc cttgttattt agaaagactt
    37381 acggtatttt ttctaaaaat cctctaacaa aacaaattcg atccaagtat ggagaattat
    37441 ttttagtcac tagaaaatct gcggaaattt tagaaggagc atggtttatt cggctaacag
    37501 acgatgatat tgcctatttg acgattcata ttggaggatt tttaaaatat acaccatcgt
    37561 ctcaaaaaaa tatgaaaaaa gtttatctcg tttgtgatga aggtgttgcg gtttcgagac
    37621 ttttgctgaa acaatgcaaa ctttattttc caaatgagca aattgacact gtatttacaa
    37681 cagaacaatt taagagtgtg gaagatattg cacaagttga tgtagtgatt actactaatg
    37741 atgatttgga tagcagattt ccgattttaa gggttaatcc tatccttgaa gcagaagata
    37801 ttttgaaaat gctagactat cttaaacaca atatatttcg taataagagc aaaagtttca
    37861 gtgaaaatct ttctagtctt atttcgtctt atattgtaga cagcaagttg gctagtaagt
    37921 tccaagaaga ggttcaaaca cttataaatc aagaaatagt agttcaagct tttttggaag
    37981 atatttgaag gacagtccaa tgatgaacac aaacctgtgt ttttcttggt cttttttagt
    38041 gttttgaagg gtggtatact aatctcaaag ataacaatta tatccaaagg aggcaacata
    38101 tgccaaacgt caaagaaatt acaagagagt catggatttt agccactttc ccagagtggg
    38161 gaacatggtt gaacgaagaa atcgaagaag aagtcgtacc tgaaggcaac tttgccatgt
    38221 ggtggctagg caactgtggt acttggatta agacaccagc tggtgctaac gttgtcatgg
    38281 acctttggtc aaaccgtgga aaatcaacca aaaaagtgaa agatatggtt cgtgggcacc
    38341 aaatggcaaa tatggcaggt gttcgtaagt tgcaaccaaa cttgcgtgtt cagccaatgg
    38401 ttatcgatcc atttgctatc aacgaactag actattactt agtttcacac ttccacagtg
    38461 atcatatcga cccatacaca gctgcagcaa ttctcaacaa tcctaagtta gagcatgtta
    38521 agtttatcgg tccttaccac tgtggacgaa tctgggaagg atggggggtt ccaaaagaac
    38581 gtatcatcgt tgttaaacca ggtgacacta tcgaattaaa agatatgaag attcatgcag
    38641 tagaatcatt tgaccgtact tgcttggtaa ctctcccagt gaacggtgct gatgagacag
    38701 gcggtgaact tgctggcttg gctgttacag atgaagaaat ggctcaaaag gctgttaact
    38761 atatctttga aacaccaggt ggaaccatct atcatggtgc agattctcac ttctcaaact
    38821 attttgcaaa acatggtaaa gactttaaaa ttgatgttgc tttgaataac tatggtgaaa
    38881 atccggtagg tatccaagac aaaatgacat ctatcgacct tcttcgtatg gcagaaaatc
    38941 tgcgtaccaa agtcattatc ccagttcact atgatatctg gtctaacttc atggcttcta
    39001 ctaatgagat tctagaactt tggaaaatgc gaaaagatcg cttgcaatac gatttccatc
    39061 catttatctg ggaagttggc ggtaagtaca cttatcctca agatcaacac ttagtagaat
    39121 accatcatcc acgtggtttt gatgattgtt ttgaacaaga ctctaacatt caatttaaag
    39181 ctttgctata atataaaaat attctttgga ggttatccgt atgttgcatg atacggataa
    39241 ttttcatata atagtaaaat agaatgtgtg attcaataat cacctcaata gaaaggaaat
    39301 tctatgtcaa atctatctgt taatgcaatt cgttttctag gtattgacgc cattaataaa
    39361 gccaactcag gtcatccagg tgtggttatg ggagcggctc cgatggctta cagcctcttt
    39421 acaaaacaac ttcatatcaa tccagctcaa ccaaattgga ttaaccgcga ccgctttatt
    39481 ctttcagcag gtcatggttc aatgctcctt tatgctcttc ttcacctttc tggttttgaa
    39541 gatgtcagca tgaatgagat taagagcttc cgtcaatggg gttcaaaaac accaggtcac
    39601 ccagaatttg gtcatacggc agggattgat gctacgacag gtcctctagg gcaagggatt
    39661 tcaactgcta ctggttttgc ccaagcagaa cgtttcttgg cagccaaata taaccgtgaa
    39721 ggctacaata tctttgacca ctatacttac gttatctgtg gagacggaga cttgatggaa
    39781 ggtgtctcaa gcgaggcagc ttcatacgca ggtttgcaaa aacttgataa gttggttgtt
    39841 ctttatgatt caaatgatat caacttggat ggtgagacaa aggattcctt tacagaaagt
    39901 gttcgtgacc gttacaatgc ctacggttgg catactgcct tggttgaaaa tggaacagac
    39961 ttggaagcca tccatgctgc tatcgaaaca gcaaaagctt caggcaagcc atctttgatt
    40021 gaagtgaaga cggttattgg atacggttct ccaaacaaac aaggaactaa tgctgtacac
    40081 ggcgcccctc ttggagcaga tgaaactgca tcaactcgcc aagccctcgg ttgggactac
    40141 gaaccatttg aaattccaga acaagtatat gctgatttca aagaacatgt tgcagaccgt
    40201 ggcgcatcag cttatcaagc ttggactaaa ttagttgcag attataaaga agttcatcca
    40261 gaactggctg cagaagtaga agccatcatc gacggacgtg atccagtcga agtgactcca
    40321 gcagacttcc cagctttaga aaatggtttt tctcaagcaa ctcgtaattc aagtcaagat
    40381 gccttgaatg ttgtggcagc taaattacca accttcctag gtggatcagc tgaccttgct
    40441 cactcaaaca tgacttatat caagacggat ggacttcaag acgatgccaa tcgcttgaat
    40501 cgtaacattc agtttggtgt tcgtgaattt gcaatgggaa caatcttgaa cgggatggcc
    40561 cttcatggtg gacttcgtgt atacggtgga actttcttcg tcttctctga ctatgtgaag
    40621 gcagctgtcc gcttgtcagc cttacaagga cttcctgtga cttatgtctt tacccatgat
    40681 tcaatcgcag ttggggaaga tggtccgact cacgaaccag ttgagcattt agcaggtctt
    40741 cgtgctatgc caaatctaaa tgttttccgt ccagcagatg cgcgtgaaac gcaagcagct
    40801 tggtaccttg cagtgacaag tgagaaaaca ccaactgccc ttgtcttgac acgtcaaaac
    40861 ttgactgttg aagatggaac agacttcgac aaggttgcta aaggtgctta tgttgtatat
    40921 gaaaatgcag ccgactttga taccatcttg attgcgacag gttcagaggt taatcttgct
    40981 gtctcagctg ctaaagaatt ggctagtcaa ggcgaaaaaa tccgcgtagt cagcatgcca
    41041 tctacagatg tctttgataa acaagatgca gcttacaagg aagaaattct tccaaatgca
    41101 gtccgccgtc gtgttgcagt cgaaatgggt gcaagtcaaa actggtacaa atatgttggt
    41161 ctcgatggtg ccgttctagg tattgatacc ttcggagcct ctgccccagc accaaaagta
    41221 ttggcagaat atggctttac tgtcgaaaat cttgtaaaag ttgttcgaaa tttgaaataa
    41281 tcctaaaaat cagggcgtaa gctctggttt ttcttaccag aaaagtaagg tacaatcttg
    41341 taaaagtagc tgaaatttga tatagtagtc ctatgtaaaa gacaaaggag aaaacaatga
    41401 atccaaatat tactttttta atcatgcttg taggtatgat ggccttgatg ttctttatgc
    41461 aacgttctca aaagaaacaa gctcaaaagc gtatggaaag cttaaataaa ctacaaaaag
    41521 gctatgaagt gattacaatc ggtggacttt atggaacagt cgatgaagta gatacggaga
    41581 agggaacaat agttcttgac gtagatggag tttacttgac ttttgaacta gctgctatca
    41641 agacagtatt accgctgaaa gaaacagctt cactagaagg cgcaattgaa aaataagacg
    41701 ggatcacgaa ctcccgtttt ctataaaaga aaggaaatgg gatgaaaaaa ttagtctttg
    41761 tctgtctggg aaatatttgc cgtagcccta tggccgagtt tgttatgaaa tcaatgacag
    41821 ataactacga aatccaaagt cgagcaactt cctcttggga acatggcaat ccgattcata
    41881 aggggactca gggaattttt caagagtatg agattcctta tgacaagaac aagacatcgc
    41941 ttcagattag taaggaagat tttgaagcct ttgattatat tatcggaatg gacgcttcaa
    42001 atatttctga cttacgtcag atgtgtccag tagactgtca agataagatt tactcatttt
    42061 catctgaaag tgttccagac ccttggtata caggagattt tgaagaaacc tatcgacgtg
    42121 ttcaagaggg ctgtcaagct tggttagaac gtttagaaaa ggagagttaa ggtggaaaat
    42181 cttacgaatt tttacgaaaa gtatcgtgtc tatctgactc gtccacgttt agagcttttg
    42241 gcagtagtta ccattgtttt ctgtgctgta ctcgtctttt ttctaaatat tccaggaaaa
    42301 ggtgtcttaa aactcgataa tggaacgatt gtttatgatg gcagtcttgt ccgtggtaaa
    42361 atgaatggcc aaggtaccat taccttccaa aatggagacc aatatacagg tggcttcaac
    42421 aatggagcct tcaacggaaa aggtaccttt caatctaaag aaggctggac ctacgaaggt
    42481 gattttgtaa atggtcaggc tgaaggaaaa gggaaactaa caacagaaca agaagtcgtt
    42541 tatgaaggaa cttttaaaca aggcgttttt caacaaaaat aaagcctcct tatcaaagga
    42601 ggtattatta gaatcacaag gtaagcgctt acctgtaaat ctctttcttt ccaaatccct
    42661 cttccaagca agtttgtgaa ataaaaaata tttgaaataa atttcacaaa cttcaaagat
    42721 aaaacctgat aagaaaagaa aatgagaaaa gtttcacaag agtttaaaaa ttctttgtga
    42781 aatgtttatg aaactgttta caaagttgaa ataatacgtt ataataaact tgtgaaaaaa
    42841 ttaacaaagg atatcgatcc ttgaaagctg tggaggaaaa tatggctgat aaaaaaactg
    42901 tgacaccaga ggaaaagaaa ctcgttgctg aaaaacacgt agatgagttg gttcaaaaag
    42961 ctctagttgc ccttgaagaa atgcgtaaat tggatcaaga gcaagttgac tacatcgttg
    43021 ccaaagcatc agtagcagct ttggatgccc acggagaatt ggctttacat gcctttgaag
    43081 aaacaggacg tggtgtattt gaagataaag caactaagaa cttgtttgcc tgtgaacacg
    43141 tagtaaacaa catgcgtcac actaagacag ttggcgttat cgaagaagac gatgtaacag
    43201 gattgactct tattgctgaa ccagttggtg ttgtttgtgg tattactcca acaacaaacc
    43261 caacatcaac agcaatcttc aaatcattga tttcattgaa gacacgtaac ccaatcgtct
    43321 ttgccttcca tccatcagca caagaatcat ctgctcatgc agctcgtatc gtccgcgatg
    43381 cagctatcgc agctggtgct cctgaaaact gtgtgcaatg gattactcaa ccatctatgg
    43441 aagcaacaag tgcccttatg aaccacgaag gtgttgcgac aatccttgca acaggtggta
    43501 atgccatggt taaggcggct tattcatgtg gtaaaccagc tcttggggta ggtgccggaa
    43561 acgttccagc ttatgttgaa aaatcagcaa acattcgtca agcagcacac gatatcgtca
    43621 tgtctaaatc atttgataac ggtatggtct gtgcatctga acaagcagtt atcattgata
    43681 aagaaattta cgatgaattt gtagcagagt tcaaatctta ccacacttac tttgtaaaca
    43741 aaaaagaaaa agctcttctt gaagagttct gcttcggcgt caaagcaaac agcaaaaact
    43801 gtgctggtgc aaaattgaac gctgacatcg ttggtaaacc agcaacttgg attgcagaac
    43861 aagcaggatt tacagttcca gaaggaacaa acattcttgc tgcagaatgt aaagaagttg
    43921 gcgaaaatga gccattgact cgtgaaaaat tgtcaccagt tattgcagtt ttgaaatctg
    43981 aaagccgtga agatggtatt actaaggctc gtcaaatggt tgaatttaac ggtcttggac
    44041 actcagcagc tatccacaca gctgacgaag aattgactaa agaatttggt aaagctgtta
    44101 aagctattcg tgttatctgt aactcacctt ctacttttgg tggtatcggg gacgtttaca
    44161 atgccttctt gccatcattg acacttggat gtggttctta cggacgaaac tcagttgggg
    44221 ataacgttag tgccattaac ctcttgaata tcaaaaaagt cggaagacgg agaaataaca
    44281 tgcaatggat gaaacttcct tcaaaaacat actttgaacg tgattcaatt caataccttc
    44341 aaaaatgtcg tgacgttgaa cgtgtcatga tcgttactga ccatgccatg gtagagcttg
    44401 gtttccttga tcgtatcatc gaacaactgg accttcgtcg caataaggtt gtttaccaaa
    44461 tctttgcgga tgtagaaccg gatccagata tcacaactgt aaaccgtggt actgagatta
    44521 tgcgtgcctt caaaccagat accatcatcg cactcggtgg tgggtctcca atggatgctg
    44581 ccaaagtaat gtggcttttc tacgagcaac cagaagtgga cttccgtgac cttgtccaaa
    44641 aattcatgga tatccgtaaa cgtgccttca agttcccatt gcttggtaag aagactaaat
    44701 tcatcgcgat tccaactaca tctggtacag gatctgaagt aacaccattt gccgttatct
    44761 ctgataaagc aaacaaccgt aaatacccaa tcgctgacta ctcattgaca ccaactgtgg
    44821 caattgtaga ccctgctttg gtattgacag ttccaggatt tgttgctgct gatactggta
    44881 tggacgtatt gactcacgcg acagaagcat acgtatcaca aatggctagt gactacactg
    44941 atggtttagc acttcaagct attaaattgg tctttgaaaa tctcgaaagc tcagttaaga
    45001 atgcagactt ccactcacgt gagaaaatgc ataacgcttc aacaatcgct ggtatggcct
    45061 ttgccaatgc cttcctaggt atttctcact caatggccca taagattggt gcgcaattcc
    45121 acacagttca cggacgtaca aatgccatct tgcttccgta cgttatccgt tacaacggta
    45181 cacgtccagc taagacagca acatggccta agtacaacta ctaccgtgca gatgaaaaat
    45241 accaagatat cgcacgcatg cttggacttc cagcttctac tccagaagaa ggggttgaat
    45301 cttacgcaaa agctgtctac gaactcggtg aacgtattgg gatccaaatg aattttagag
    45361 accaaggaat tgacgaaaaa gaatggaaag aacattctcg taaattagcc ttcctggctt
    45421 atgaagacca atgttcacca gctaacccac gtcttccaat ggtagaccat atgcaagaaa
    45481 tcatcgaaga tgcatactat ggctacaaag aaagaccagg acgccgtaaa taattgttta
    45541 tcagtctaga agcaagacaa aaactcaatt tgagggaaag atccagtaat ttttctatga
    45601 taaaaggcat cctatcaagg tttttgaata cctgatagga tgccttttta tgatgttgag
    45661 gcctttttgc cctttttgaa aaactagaat agaaacaaaa tatatagtag gttgaaacta
    45721 gaatagtaca catctgctgc taaaacattt atagaaatta attttacttt tctgatagag
    45781 ttgttcacat cttatttcaa ttcactatag tttaatttaa gagtagtatt tactaaggcc
    45841 caattaaaat caaagagcaa acgagaaaac gatgacaagg tgtgttgctt tttgatttct
    45901 aaagagtata atgatagatc tctataaaat aagtgcgaag gaaatgagct tttataatcc
    45961 tttcgtttta aaatactatc tcagatattc ttatatcgac aagaagtttt tgagtcattc
    46021 cctcatcata catattaaat aaatagtggc tcattcaatt tttcactaga ataataagct
    46081 agtatagtaa actgaaataa gatataaaca aataaattgg agcttaacat ctatttccag
    46141 caatttttta gaaactgcag tggactattc taaattcaac acattataaa aactagagta
    46201 aaagaaaagg attggatctt gtgtaatgca ggatccaatc ctttcaatca ttttgtccaa
    46261 cttttggagg ttcctacaat gtagccgtca ttaataaaga cagatgggaa cgacagtgtt
    46321 cctatttatt ttgatagaga tcgatgaatt ctttagatag caactgaata atctctgttg
    46381 aagccatttg gtcttctgca tgcataaata gcaaggagaa tcctattttt tctccagtag
    46441 cttctttttg tatgagatta gagtgaatct tgtgcgcttc tactaaggag tcttccgctt
    46501 cttcaacttt aattttcgct tcttttaaat ttcctgcctt agctagttgg atggcttcaa
    46561 taaaggatga tttggctgct ccactattgg caatgagctg aaaacagata tattccattt
    46621 cttctgtcat cttatttctc ctatccatgc aagtgcttgt tccagaactt ttgctccatt
    46681 catcattccg taatcccgca tatcaatggt atctacaggg atatttcctg caatttcttt
    46741 cacagcaagt aactcataac gaatttgtgg cccaattaga atgacatctg cttcatggat
    46801 attcttttta gcttctgtca ttgattttgc ttggatagaa atttcaatcc cacgttcagt
    46861 cgcactttgt tgcatttttt taacaagcat atttgtcgac attcccgcat tacatactaa
    46921 taaaatttgt ttcataatct taaccttcca tttcttgctc aacaactttg tcattaactt
    46981 tgataaatgg aatgtataga agaactccaa gtgcaaagat gatgaattga actagaactg
    47041 ctctcacgtc ccctgctgtt gctaaccatg catttaagaa tactggtgta gtccaaggaa
    47101 cttgtataaa tgcaggactc atgaatcctg taactgttgc taagtagctg attaaaatac
    47161 caaggactgg aactgtgata aatggaatag ctaatgaaat gttataaacg attgggtaac
    47221 cgaataatac tggttcattg atattgaaga taccaggtcc aaaagataat ttagccacgt
    47281 ttttagagac agcattgcga ctcactaaga atgttgctat taataaacat aatgtagatc
    47341 cactaccacc cattaaagcg aatgtttgta tttgtgatag gttgatgatg tgtggaatgg
    47401 cttgtccatt atttgctgca gtgatgtttt cagtaatgtt aattaatagt aatggttcta
    47461 ggatggcact gtaaataact gcttggtgaa taccaaatag ccataacata tttcctaaag
    47521 agtaaataat aatgaccccg attaagcttg taccaatatg acgaattggt tcttgaataa
    47581 agattgtaat gattgagatt aagttcattc cagttatatt gaataataat gctgaaacaa
    47641 ccccaaataa ggagatgacg gtcatgactg gaagtaatac gctaaatgat ctactaacag
    47701 ctggtggaat attttcacca aggttcattt gtaaagcttt aacgtttgat aattcaatga
    47761 ataattctgt tgcaataatc gctacgataa ccccggcgaa cattgcgcct gtacctgtgt
    47821 tgttgaatga aagaacacct gaaatgttta ccgcatcttt tgctccgtca ggaactacag
    47881 aaactgtatt tggcatcatc acaattaaag aaactaatga tagcattgat gctgctaacg
    47941 ggttttcgaa atctctgttt ttagctaaga aataaccaac cattacagca ataatcatac
    48001 ctgaaatact taaagtaccg tttgcaattg ttattcccca atattggaat cttgttaatg
    48061 tatccccttg gaaaatccac ttaaataccg tgttgttcaa aagaacgatt aaacctgcca
    48121 aaatatataa tggcattact gttacgaatg catctcttag ggtttttaaa tgaatttggt
    48181 tccctagttt accagcaaag gtggcaaatt gatctataaa ttttgagttt ttcatctgaa
    48241 tatctcctct ctttactcct caatttctac ttcaaaaccg ttattgtcac ttactttgcg
    48301 ataccatctt cctgagctct tgatggttct cttttgcgtt tctaaatcaa cggagataaa
    48361 tccgtaacga ttcttatatg cattattcca agaccagcaa tcaaatgcgg tccaagcgtg
    48421 gtatccaaaa cagtgacttc cctcttcaat ggctttatgt agccatctta aatgttcttc
    48481 ataaaattca atacgataca cgtcatcgat aactccattt tcaccgataa accgtgcttc
    48541 gttttcaaca cccattccgt tttcactgat aaaccatgga atattatcat attcttcctt
    48601 cacaatcata gcaatatcat aaatggcttt cggaaaaatt tcccaaccac gatatggatt
    48661 catgcgacgc tccggccatt catactcttt gaagtattgg tctggcatcc agggcgtctg
    48721 atattcctca ggatttgctt gtgcttgaac acgttttgga tggtagtagt ttactccaag
    48781 aaaatcaacc gtatttgatt tcatcagttg aagctctttt tcggtatgac tccataacac
    48841 gccatctctc tctagctgtt ttaccaatct ttctgggaaa gttcctttaa cagctggatt
    48901 caagaagact ttgttaaaga agtcatctgt aaatcgactt gcttctaagt cttctggaga
    48961 attacttctt ggataagcag gtgtcaagtt taaaataatc ccaatctttc catcaagtcc
    49021 taatgagcga tatagttgaa tcacttttgc actagcaagg tttagattat agatgatttg
    49081 tacggcctct tttccctttc cttttagatt tggataatgg aaagcatata agtatcctgc
    49141 ttctggaatg accattggct cattgaaagt tgtccagtaa tgaaccttat ctccaaagca
    49201 tgtgaaagca gtcttggcaa acttcacgaa taactccact acatgtttgc tttcccaacc
    49261 accgtatttt tgaagaagtt ccactggtaa atcaaaatga tgtaaattca tcacaagatc
    49321 catctggttc tttttagctt cttcaatgat ggcattgtag aaagcaatac cttttggatc
    49381 aggctcacct gtctctaaat tcttgatgag tcgactccat tggatggaag tgcggaaaga
    49441 attaactcca atttccttca tcaagtggaa atcttcggtg taagtatgaa aaaagttact
    49501 ggctacaaga ggtccgacat tatcgaaaaa atcttctgga tgcgttttga accagtagtc
    49561 catcacattt tcatgtactt ttccatattg accttctgtc tgaggtccgc tagaagcagc
    49621 cccccaccaa aacagattag gaaatactaa cttttttttc atgctcaacc tcctttctat
    49681 tattctatac ataaagtata gcataatttt aaaatttgtc tagacatttt taaaaattgt
    49741 ttatacatat cttgtgtttg cctcatttct tgaactttgt tatactacta ttagaatatt
    49801 atagagagaa ccagattaaa tgagtacaaa atatttattt atttacaatg agattcgtga
    49861 aaagattctt tgtaataaat ataccatgaa cgaacaattg cctgatgaaa tgacattagc
    49921 taaacagttt gcctgtagtc gaatgacgat caaaaaagct ttagacttgt tagtttctga
    49981 gggcttaatt tttagaaaac gtgggcaggg aacctttgtt ctctctcgtg gcagctcaaa
    50041 aagaaaatta atcgttccag aaagagatat ccggggactg acaaaaatat ctgaagatgc
    50101 tcattctaca attgactcga ggattattca cttcaaatta gaatttgcaa atgaattttt
    50161 agcagaaaaa ctacaggtcg ctttgcagag tccagtttat aatatttacc gcctgcgtat
    50221 tattgacggt aaaccttatg ttctggaaca aacttatatg agtaccgatg ttattccagg
    50281 tattactgaa gatattttac aaaaatcgat ttacaattac attgaaggaa agttaggatt
    50341 gcatattgcc agtgctacaa aaatcttgcg agcttcttct agttcagaaa atgagcaaca
    50401 ttacttgcag ctccttccaa cggaaccggt atttgaagta gaacaagtgg cttatttgga
    50461 taacggaact ccgtttgagt actcgattag tcgtcatcgc tatgatttat ttgaatttaa
    50521 ttcttttgca ttacgacatt cctcctagga gaaaatgtga aaatgaagcc aatcttttac
    50581 agactctagt ttaagaaaaa tttaaaacag ggcaagaagg tcccatctat gcttaaatgg
    50641 tttctctttt ctaaataaga tggctttaaa agagtgatcg ttttatccat catgttgaaa
    50701 aatatcttcg tatagcttat agagtaggta ctgaaattgt tcacctgatc tacttcttat
    50761 agttatttag ttttaaatag tgtttcaaac attcttacac tgacgagaag tttttgagtc
    50821 ttttcttgta acacatatag tatactgagg ttagaatagt agactgtgac ttctaacaaa
    50881 ttgctagaaa tgaatttcaa tctcccaatt tatttgttca tatcttcttt tgatatatta
    50941 aataaattct gaatcataat catttaaaaa aattttattt tttatttttc attacgaata
    51001 atatagatga aggggaaaga gtatgaaaac agaactgttt cttttgctat tagttcaaaa
    51061 ggagaaaaaa tgaaagtaga aaatatttcg tatagggtgg atcatcgtat attgtttgat
    51121 aatatttctt ttgatacttc gagttcaggc gtgacattaa ttactggtaa aaatggtaca
    51181 ggaaagtcaa ctttactata gtagattgaa actagaatag tacacatcta cttctaaaat
    51241 attgttagaa attgatttga ctatcctgat ctatttgtcc tgttcttatt tcatttcact
    51301 atatctcaaa ttgagtatga cgaagtgcgc tcccatgtcc tgggaacgca ctttcttcat
    51361 atttttcata ttcttgaatc catcgataaa gactattggg atgaattttt aaagttgaac
    51421 taatcatttt tacaggatga gatttacagc agagagtttg aaggctttat caaaggtttt
    51481 tcttggcata atgacttttc ctcgtttcca cttaattttg tgtctacttt attataccaa
    51541 gtccaccctt aagttagata ataaatctaa cttaaggaag ctagaaggat gagaatccag
    51601 gtggtcaaga gtcccaaact taagctgatg gggacaccca gaataatttg ctttttgaag
    51661 gcaaggccac gttcctctat attgggaagt gagagttgaa tgagagaacc agctgatgaa
    51721 aagggtgaga tattagtaga tagagcgcca ataacggtgg ctgttgtgag taagtgaata
    51781 tcaatctgag gattttgagc actgatgata gcaatgatgg gaaagagggc tggagctaca
    51841 acggataggg tggaactaaa gagtgacatc actccggcta tcacacaaaa gaacagaggt
    51901 aaccagaaat gaggaatggt tgttgtcatg aggtgcccta tcagtgtgac taaacctgac
    51961 ttgaccgcta gagacattag taagctcatg ccgcagagca tgataattgt agcccaggga
    52021 accttagcta aaatggcttc ttgcttccct aatttgagcc ttaaggcgag gcagaccatg
    52081 agtattgaga caaagccaat atcaaatgtt ttttgataag tagctatcca ggcgatgttt
    52141 gggaaaatga gatgcaacaa gggaaaaagc caaaccaaaa ccatgctgct gatcatgagc
    52201 aaggtggttt gtctttgaac cttgctgagg agtggtggtt ggtcaatagt caaggatgag
    52261 tttgttcttc ccttactata gtgactgtaa caggataata aaagcaagac gatgagtggg
    52321 tagataatgc tgacgataaa gatatgattg ccaagtgaaa aagcttgctc ctcccatccc
    52381 atttgcttaa acaggccttg aaagacaatg cctgagctac tggttatcaa attagcccct
    52441 cctgaagctc cccaattgac ggcttgagct ccaatcaaag ggtgtttgtc cgctttttga
    52501 cagagggtaa tcgctagagg acagcaaacg gccatagtag tgaaaaatcc agcacctaaa
    52561 gcagacaaaa gggttgccat caggtataaa atcatgtaga gggcgttagg gtgggtgcgt
    52621 gtgcggtaga gaatgtgttg agccaaaaca tcaagagtac cgttagttgt tgcaacgtta
    52681 taaaagagag agacgctaaa aatggtaaaa aagagtgagg ttggccaaaa atgaagaagt
    52741 tctttggggc ttaatcccat gagagtggtt gcgatgaggt aagaaaaagc aatagccagc
    52801 aggccaatat tgattttggt gcggtaacca attccaatgg ctagagcaat ggcgctaatc
    52861 attattaaat gaatcattga attgtccttt cagttagaat atggaaatag gttggcaatt
    52921 ttggcgctca aaagaccacc tgtttcctat tggtacttga ctattataca caaaaaaaat
    52981 acaattgtct tgacaattgt attgacactt gttagaatta aaaatgaggt attcaggctt
    53041 gtgatttcct atggaagtta atagtaattg cctctagtgc ttacaagtga tattaaaaat
    53101 agaggactta gtgatgtcaa tcatttcaac tgatttaacc ccttttcaaa tagatgatac
    53161 attgaaagca gccttgcgag aagatgttca ttccgaagat tacagtacca atgccatttt
    53221 tgatcatcat ggccaagcca aggtgtcgct ttttgccaag gaagctggtg ttttagcggg
    53281 actaaccgtt tttcaaaggg tttttaccct atttgatgcc gaggtgacct tccagaatcc
    53341 tcatcaattt aaggatgggg atcgtttgac tagtggcgat ttggttttag aaatcatagg
    53401 ctcggtgaga agtctcttaa catgtgaacg cgttgccttg aattttttac aacatttatc
    53461 agggattgct tcgatgacag ctgcttatgt agaagcctta ggcgatgatt gcattaaggt
    53521 atttgatact cgaaaaacta ctcctaattt acgtcttttt gagaaatatg ccgtgagagt
    53581 tggcggtggc tataatcatc gctttaattt atcagatgct atcatgctaa aagacaatca
    53641 cattgcggca gtaggtagtg ttcaaaaggc aattgctcaa gcgcgtgcct atgccccttt
    53701 tgtgaaaatg gtcgaggtgg aagtggaaag ccttgctgct gccgaagaag ctgcggcggc
    53761 gggtgctgat attatcatgt tggataatat gtcattggaa cagattgaac aggccattac
    53821 cctaattgca ggacgttctc ggattgaatg ttctggaaat attgatatga ccactattag
    53881 ccgttttcgt ggtttagcga ttgattacgt ctccagtggt agtttaaccc atagtgctaa
    53941 gagtcttgat ttttccatga agggtttaac ctaccttgat gtctaagttg taaaataaac
    54001 taacttttta aaggatgtct ttcctctaga acgagtttta tgtcagatag tttaaacgcc
    54061 tcttcaaata tagtaaaatg aaccaaaaat agtacaaaat gtggtataat ctt
//
LOCUS       DBERMM010000010        50574 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.010, whole genome shotgun sequence.
ACCESSION   DBERMM010000010 DBERMM010000000
VERSION     DBERMM010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 50574)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 50574)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..50574
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.010"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..89)
                     /locus_tag="ACL8AS_000787"
     CDS             complement(<1..89)
                     /locus_tag="ACL8AS_000787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HGS1228679.1"
                     /translation="MNTLAEKFRLKRKELGLSQQTLAEGICEQ"
     gene            277..446
                     /locus_tag="ACL8AS_000788"
                     /pseudo
     CDS             277..446
                     /locus_tag="ACL8AS_000788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhrA family quorum-sensing system peptide"
     gene            761..1057
                     /locus_tag="ACL8AS_000789"
     CDS             761..1057
                     /locus_tag="ACL8AS_000789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000911560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HGS1228680.1"
                     /translation="MLKFRKVVASSLAVLAFSLALPVLAVSHRGGEWTYGGHHDPYNW
                     GAFSNYYHGSQYHWAYVGSNERDNQKTVYAGAHSAAYAFVNTNLGERITFDAGW"
     gene            1160..3175
                     /locus_tag="ACL8AS_000790"
     CDS             1160..3175
                     /locus_tag="ACL8AS_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="HGS1228681.1"
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSHYYPNVVVHDSSPE
                     TTFQHVATRLEKLAEETDSFIAIQHQDPNSEGTTVFSYTTFGDGKLPDGLQEKKLEDA
                     QSSSVETNYFVFDGHLDIHLLREELSQLGLTNMHLTIPSKLSTLMAIFSNGFQLISLL
                     IFILTFGALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLTI
                     LMQKILSLPTQSLMTIGAGLLSYNLILLSISLFFAQLFAVGIKKIHLMQIIKGQVPVR
                     GIISLILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSISREGTS
                     PGFDEQAQRKLRTWYQLMDLAVSEQKAFLSRHQLIDRTLQNGMASSKNFITSTEWHDY
                     SPNGNVLIVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEDHYKSVFED
                     DLTSRMSSQDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQ
                     SILFWIDAVQNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVM
                     LAGAVLGIATSILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLG
                     FVASVFLQVEIGVAFLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            3177..3809
                     /locus_tag="ACL8AS_000791"
     CDS             3177..3809
                     /locus_tag="ACL8AS_000791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228682.1"
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLM
                     NMIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIG
                     QKLSRSEQRLRQKQALEQVGLAYLDLDKRIFELSGGESQRVALAKIILKNPPFILADE
                     PTASIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            3950..4228
                     /locus_tag="ACL8AS_000792"
     CDS             3950..4228
                     /locus_tag="ACL8AS_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComA"
                     /protein_id="HGS1228683.1"
                     /translation="MKKFDNYIIEKPCDSNSDKLQKILIIENLVDDILQFPLRINNSV
                     GEIFLLQPFQKKTIFIPCYFEEDIVKVKDDDKVEWNLLEFQKFRAFLA"
     gene            complement(4738..5151)
                     /gene="ndk"
                     /locus_tag="ACL8AS_000793"
     CDS             complement(4738..5151)
                     /gene="ndk"
                     /locus_tag="ACL8AS_000793"
                     /EC_number="2.7.4.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="HGS1228684.1"
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEE
                     LIDQHYQDLVGQSFYLPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTI
                     RGDFAKAAGENEVIQNVVHGSDSEESAKREIALWF"
     gene            complement(5262..8939)
                     /gene="rpoC"
                     /locus_tag="ACL8AS_000794"
     CDS             complement(5262..8939)
                     /gene="rpoC"
                     /locus_tag="ACL8AS_000794"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HGS1228685.1"
                     /translation="MVDANRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPERE
                     GLFDEVIFGPTKDWECACGKYKRIRYRGIVCDRCGVEVTRTKVRRERMGHIELKAPVS
                     HIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLR
                     EYGYGSFVAKMGAEAIQDLLKQVDLEKEIAELKEELKTATGQKRVKAIRRLDVLDAFY
                     KSGNKPEWMILNILPVIPPDLRPMLQLDGGRFASSDLNDLYRRVINRNNRLARLLELN
                     APGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLG
                     KRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDIVQNVKAAKRLVE
                     RGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNAD
                     FDGDQMAIHVPLSEEAQAEARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEA
                     GREGEGMVFKDRDEAVMAYRNGYVHLHSRVGIATDSLNKPWTEEQRHKVLLTTVGKIL
                     FNDIMPEGLPYLQEPNNANLTEGVPAKYFLPLGGDIKEAISNLELNPPFKKKNLGNII
                     AEIFKRFRTTETSALLDRMKNLGYHHSTLAGLTVGIADIPVVDDKTEIIEESHKRVEQ
                     ITKQFRRGMITDDERYNAVTAEWRAAREKLEKRLIANQDPKNPIVMMMDSGARGNISN
                     FSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSG
                     YLTRRLVDVAQDVIIREDDCGTDRGLLIRSIAEGKEMIESLEERLNGRYTKKTVKHPE
                     TGAVIIGPNELITEDKAREIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVE
                     VGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVI
                     TEVKGQVTAIEEDASTRTKKVFVKGETGEGEYVVPFTARMRVEVGGQVARGAALTEGS
                     IQPKRLLAVRDVLSVETYLLGEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDT
                     DLLMGTLMDINDFTDANKDVLIAGGVPATGRPVLMGITKASLETNSFLSAASFQETTR
                     VLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPHAVNEEEYLNPTVEEEG
                     NEETTEVVVDTAVETVEETVE"
     gene            complement(8972..12583)
                     /gene="rpoB"
                     /locus_tag="ACL8AS_000795"
     CDS             complement(8972..12583)
                     /gene="rpoB"
                     /locus_tag="ACL8AS_000795"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HGS1228686.1"
                     /translation="MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHG
                     LKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKE
                     TGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGS
                     TVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVR
                     NTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVG
                     RYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKI
                     VYIPNDAAVVTEPVVLQKFKVVAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYF
                     LNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQ
                     QIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVR
                     DVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIV
                     WLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVA
                     VATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQY
                     DGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIAD
                     GPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDT
                     KLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERL
                     LHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRK
                     IKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHL
                     GMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGV
                     MYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVL
                     QEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQ
                     EVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE"
     gene            12999..13069
                     /locus_tag="ACL8AS_000796"
     tRNA            12999..13069
                     /locus_tag="ACL8AS_000796"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:13031..13033,aa:Cys,seq:gca)
     gene            complement(13267..14598)
                     /locus_tag="ACL8AS_000797"
     CDS             complement(13267..14598)
                     /locus_tag="ACL8AS_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin family protein"
                     /protein_id="HGS1228687.1"
                     /translation="MEDPSSQNLLLQFVLLFILTVLNAFFSATEMAMVSLNRARVEQK
                     AEEGDRRYIRLLKVLENPNHFLSTIQVGITLITILSGASLTDTLGRVIASWLGNGETA
                     QAVATFLSLAFLTYISIVFGELYPKRIALNLKDALAIRTAPVIIGIGKLVSPFVWLLA
                     ASTNFLSHLTPMSFDDADEKMTRDEIAYMLTNSEETLDADEIEMLQGVFSLDELMARE
                     VMVPRTDAFMVDIQDDSQAIIQSILKQNYSRIPVYDGDKDNVIGIIHTKSLLKAGFVD
                     GFDNIVWKRILQDPLFVPETIFVDDLLKELRNTQRQMAILLDEYGGMAGLVTLEDLLE
                     EIVGEIDDETDKAAIDVYQIGEDTYIVQGTMTLNDFNNYFNVELESDDVDTIAGYYLT
                     GVGTIPTTEKLSYELISQNKQFILTNDKVKNGRVTKVKIQITEVEIEEETE"
     gene            complement(14889..15713)
                     /gene="endA"
                     /locus_tag="ACL8AS_000798"
     CDS             complement(14889..15713)
                     /gene="endA"
                     /locus_tag="ACL8AS_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-entry nuclease EndA"
                     /protein_id="HGS1228688.1"
                     /translation="MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSAPNSPKTNLSQKKQ
                     APEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTK
                     TVGKETVPTVANALLSNATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
                     LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRV
                     RYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ"
     gene            complement(15752..15940)
                     /locus_tag="ACL8AS_000799"
     CDS             complement(15752..15940)
                     /locus_tag="ACL8AS_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HGS1228689.1"
                     /translation="MNKKSSYVVKRLLLVIIVLILGTLALGIGLMVGYGILGKGQDPW
                     AILSPAKWQELIHKFTGN"
     gene            complement(15933..17216)
                     /gene="murA"
                     /locus_tag="ACL8AS_000800"
     CDS             complement(15933..17216)
                     /gene="murA"
                     /locus_tag="ACL8AS_000800"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA];
                     GO_process: GO:0019277 - UDP-N-acetylgalactosamine
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HGS1228690.1"
                     /translation="MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQ
                     NVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVL
                     GPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
                     YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETIT
                     ITGVEKLHGTTHNVVQDRIEAGTFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVE
                     VIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFEN
                     RFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETV
                     VGKLVHLDRGYYGFHEKLAQLGAKIQRIEASDEDE"
     gene            complement(17240..17470)
                     /locus_tag="ACL8AS_000801"
     CDS             complement(17240..17470)
                     /locus_tag="ACL8AS_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014017351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1146 family protein"
                     /protein_id="HGS1228691.1"
                     /translation="MVQLLFTLSSHMLFIYVSFYLLKDLVRWEKVLKVTAENTRKVRV
                     LVAFFSIVIGYILSSFFISLYHLWQEALRGLL"
     gene            complement(17528..18565)
                     /locus_tag="ACL8AS_000802"
     CDS             complement(17528..18565)
                     /locus_tag="ACL8AS_000802"
                     /EC_number="3.4.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SepM family pheromone-processing serine
                     protease"
                     /protein_id="HGS1228692.1"
                     /translation="MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLK
                     VNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFTDIRSAQETTGGSSDVEFMRINQ
                     FYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
                     DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVIS
                     NVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGID
                     KKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAKTIKTDMKIVPVKTL
                     QDAIDYLKNNP"
     gene            complement(18549..19037)
                     /gene="coaD"
                     /locus_tag="ACL8AS_000803"
     CDS             complement(18549..19037)
                     /gene="coaD"
                     /locus_tag="ACL8AS_000803"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004595 - pantetheine-phosphate
                     adenylyltransferase activity [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HGS1228693.1"
                     /translation="MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQ
                     GFLPLENRKRGLEKALGHLENVEVVASHDKLVVDVAKRLGATFLVRGLRNAADLQYEA
                     SFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACHVPESILEEIRNEK
                     KD"
     gene            complement(19027..19566)
                     /gene="rsmD"
                     /locus_tag="ACL8AS_000804"
     CDS             complement(19027..19566)
                     /gene="rsmD"
                     /locus_tag="ACL8AS_000804"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052913 - 16S rRNA
                     (guanine(966)-N(2))-methyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0031167 - rRNA methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HGS1228694.1"
                     /translation="MKIISGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEGGR
                     VLDLYAGSGGLSIEAVSRGMSSAVLVERDRKAQTIVAENIQMTKEVGKFQLLKMDAER
                     ALEQVSGEFDLVFLDPPYAKEQIVADIEKMAERELFSEDVMVVCETDKAVELPEEIAC
                     LGIWKEKIYGISKVTVYVR"
     gene            complement(19631..20623)
                     /gene="asnA"
                     /locus_tag="ACL8AS_000805"
     CDS             complement(19631..20623)
                     /gene="asnA"
                     /locus_tag="ACL8AS_000805"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004071 - aspartate-ammonia ligase
                     activity [Evidence IEA];
                     GO_process: GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HGS1228695.1"
                     /translation="MKKSFIHQQEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGM
                     QDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRHTLARFGFGEGEGLFVHMKALRPD
                     EDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYDIESI
                     LPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDY
                     DDWTSESENGYKGLNGDILVWNESLGGAFELSSMGIRVDEETLRRQVEITGDEDRLEL
                     EWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSVWPQEVRDTYENIL"
     gene            complement(20736..21419)
                     /locus_tag="ACL8AS_000806"
     CDS             complement(20736..21419)
                     /locus_tag="ACL8AS_000806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="HGS1228696.1"
                     /translation="MNHTIIHDRAGLNQFYAKVYAFVGLGIGLSALVSGLMLTVFQSQ
                     LVYLLMQGRLWLTIATFAELALVFVASSMASRNSPAALPVFLLYSVLNGFTLSFVVAF
                     YTPGTVLSAFVSSALLFFVMAAVGIFTKKDLSGIGRAMMAALIGLLIAMVVNIFLASG
                     FFDYMISVAMVLVFSGLIAWDNQKIRLAYEQSQGRVATGWVVSMALSIYLDFINLFLS
                     ILRIFGRND"
     gene            complement(21475..22215)
                     /locus_tag="ACL8AS_000807"
     CDS             complement(21475..22215)
                     /locus_tag="ACL8AS_000807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0001510 - RNA methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TrmH family RNA methyltransferase"
                     /protein_id="HGS1228697.1"
                     /translation="MTIITSKANSVVKNAKKLHQKKYRKSAYLIEGWHLFEEAVQAGV
                     TIEKIFALENYRDQLAAFPQTVWISEDILLDLADSQTPQGIVAVVQKEEVGQADLSQG
                     KFLFLEDVQDPGNVGTIIRTADAAGFTGVIVSDKSADIYSLKTLRSMQGSHFHLPIYR
                     MTSQALLDETKKVAIPVLATTLSKDSVDYRELPSIENFVLVMGNEGQGISPLMAESAD
                     QLVHISMKGQAESLNVAVAAGILIFHLS"
     gene            22249..22527
                     /locus_tag="ACL8AS_000808"
     CDS             22249..22527
                     /locus_tag="ACL8AS_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001174612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acylphosphatase"
                     /protein_id="HGS1228698.1"
                     /translation="MQKVRMIAQGRVQGVGFRWGVYSLALEIGGITGRVWNNDDGTVE
                     ILAQADSSAIMAKFIQEIRKGPTPFSKVSYLDVKLSNFPPYSDFKIAN"
     gene            22605..23531
                     /gene="yidC"
                     /locus_tag="ACL8AS_000809"
     CDS             22605..23531
                     /gene="yidC"
                     /locus_tag="ACL8AS_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HGS1228699.1"
                     /translation="MKSIKRFAFSAMGVAMLLVLTGCVNVDKTTGQPTGFIWNTIGAP
                     MAEAIKYFATDKGLGFGVAIIIVTIIVRLIILPLGIYQSWKATLHSEKMNALKHVLEP
                     HQTRLKEATTQEEKLEAQQALFAAQKEHGISMFGGVGCFPLLLQMPFFSAIYFAAQHT
                     EGVAQASYLGIPLGSPSMILVACAGVLYYLQSLLSLHGVEDEMQREQIKKMIYMSPLM
                     IVVFSLFSPASVTLYWVVGGFMMILQQFIVNYIVRPKLRKKVREELAKNPPKASAFST
                     PSGRKDVTPEQPTAITSKKKHKNRNAGKQRSR"
     gene            complement(23606..24400)
                     /gene="pflA"
                     /locus_tag="ACL8AS_000810"
     CDS             complement(23606..24400)
                     /gene="pflA"
                     /locus_tag="ACL8AS_000810"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate-lyase-activating protein"
                     /protein_id="HGS1228700.1"
                     /translation="MSEETIDYGQVTGMVHSTESFGSVDGPGIRFIVFLQGCHMRCQY
                     CHNPDTWAMESNKSRERTVDDVLTEALRYRGFWGNKGGITVSGGEALLQIDFLIALFT
                     KAKEQGIHCTLDTCALPFRNKPRYLEKFDKLMAVTDLVLLDIKEINEEQHKIVTSQTN
                     KNILACAQYLSDIGKPVWIRHVLVPGLTDRDDDLIELGKFVKTLKNVDKFEILPYHTM
                     GEFKWRELGIPYSLEGVKPPTADRVKNAKQLMDTESYQDYMKRVHG"
     gene            complement(24526..25776)
                     /locus_tag="ACL8AS_000811"
     CDS             complement(24526..25776)
                     /locus_tag="ACL8AS_000811"
                     /EC_number="4.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000856498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008836 - diaminopimelate decarboxylase
                     activity [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HGS1228701.1"
                     /translation="MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWN
                     KGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTPD
                     KEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
                     FGMTKDQLFEAFAILKEKGAKTFGLHSFLASNTVTHLYYPELARQLFELAVEIKEKLG
                     ISLDFINLSGGIGVNYRPDQEPNDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFM
                     LAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDV
                     VGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGK
                     ARQIRRAERPEDYFATLYGFDFEE"
     gene            complement(25843..26670)
                     /gene="purR"
                     /locus_tag="ACL8AS_000812"
     CDS             complement(25843..26670)
                     /gene="purR"
                     /locus_tag="ACL8AS_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004242125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA];
                     GO_process: GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA];
                     GO_process: GO:0045982 - negative regulation of purine
                     nucleobase metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HGS1228702.1"
                     /translation="MKLRRSDRMVVISNYLINNPYKLTSLNTFAEKYESAKSSISEDI
                     VIIKRAFEEIEIGHIQTVTGAGGGVIFTPSISSQDAKEMVEDLRTKLSESDRILPGGY
                     IYLSDLLSTPAILKNIGRIIAKSFMDQKIDAVMTVATKGVPLANAVANVLNVSFVIVR
                     RDLKITEGSTVSVNYVSGSSGDRIEKMFLSKRSLKAGSRVLIVDDFLKGGGTVNGMIS
                     LLREFDSELAGVAVFADNAQEEREKQFDYKSLLKVTNIDVKNQAIDVEVGNIFDEDK"
     gene            complement(26937..27878)
                     /locus_tag="ACL8AS_000813"
     CDS             complement(26937..27878)
                     /locus_tag="ACL8AS_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exoribonuclease YhaM family protein"
                     /protein_id="HGS1228703.1"
                     /translation="MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEI
                     DGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNTPQVNQITLRLPQAGEPNDPADFKVK
                     SPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFETGLAY
                     HTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIA
                     LIDSEITKTVMELGIDDTKEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNL
                     DASMMMMSTALALVDKGEMSNKIFAMDNRSFYKPDLD"
     gene            complement(27868..29124)
                     /gene="rmuC"
                     /locus_tag="ACL8AS_000814"
     CDS             complement(27868..29124)
                     /gene="rmuC"
                     /locus_tag="ACL8AS_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HGS1228704.1"
                     /translation="MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQ
                     LDYRFDQARQASQLDQKDLEVAVSDRLQEVRIELHQGLTQVRQEMTDNLLQTRDKTDQ
                     RLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQTVAR
                     DVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPG
                     QGDQEYVYLPIDSKFPLADYYRLEEAYEVGDKDEIERCRKSLLASVKRFARDIRNKYI
                     APPRTTNFGVLFVPTEGLYSEIVRNPVFFDDLRREEQIIVAGPSTLSALLNSLSVGFK
                     TLNIQKSADHISKTLASVKTEFGKFGGILVKAQKHLQHASGNIDELLNRRTIAIERTL
                     RHIELSEGEPALDLLHFQENEEEYED"
     gene            complement(29126..29788)
                     /locus_tag="ACL8AS_000815"
     CDS             complement(29126..29788)
                     /locus_tag="ACL8AS_000815"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000006147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004788 - thiamine diphosphokinase
                     activity [Evidence IEA];
                     GO_process: GO:0006772 - thiamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HGS1228705.1"
                     /translation="MSEYKLSENNWTRVAVFAGGNRGHYRTDFDAFVGVDRGSLWVLE
                     EDLPLALAVGDFDSVTEEERQVIQKRAQHFVQARPEKDDTDLELALLTIFEQNPQAEV
                     TIFGALGGRIDHMLANVFLPSNPKLAPYMRQIEIEDGQNLIAYCSEGTSQLEPRSDYD
                     YLAFMPVRDSQLTILGAKYELTEENFFFKKVYASNEYIDREVSVTCPDGYVVVLHSKD
                     RR"
     gene            complement(29751..30407)
                     /gene="rpe"
                     /locus_tag="ACL8AS_000816"
     CDS             complement(29751..30407)
                     /gene="rpe"
                     /locus_tag="ACL8AS_000816"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA];
                     GO_process: GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HGS1228706.1"
                     /translation="MSQYKIAPSILAADYANFEREIKRLEATGAEYAHIDIMDSHFVP
                     QISFGAGVVESLRPHSKMVFDCHLMVSNPEHHLEDFARAGADIISIHVEATPHIHGAL
                     QKIRLLGVKPSVVINPGTPVEAIKHVLHLVDQVLVMTVNPGFGGQAFLPETMDKVREL
                     VALREEKGLNFEIEVDGGIDDQTIAQAKEAGATVFVAGSYVFKGEVNERVQTLRKQLD
                     "
     gene            complement(30418..31296)
                     /gene="rsgA"
                     /locus_tag="ACL8AS_000817"
     CDS             complement(30418..31296)
                     /gene="rsgA"
                     /locus_tag="ACL8AS_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HGS1228707.1"
                     /translation="MQGQIIKALAGFYYVESDGQVYQTRARGNFRKKGHTPYVGDWVD
                     FSAEENSEGYILKIHERKNSLVRPPIVNIDQAVVIMSVKEPDFNSNLLDRFLVLLEHK
                     GIHPIVYISKMDLLEDRGELDFYRQTYGDIGYDFVTSKEELLSLLTGKVTVFMGQTGV
                     GKSTLLNKLVPDLNLETGEISDSLGRGRHTTRAVSFYNLNGGKIADTPGFSSLDYEVS
                     RAEDLNQAFPEIATVSRDCKFRTCTHTHEPSCAVKPAVEEGVIATFRFDNYLQFLSEI
                     ENRRETYKKVSKKIPK"
     gene            complement(31298..32170)
                     /gene="rsmA"
                     /locus_tag="ACL8AS_000818"
     CDS             complement(31298..32170)
                     /gene="rsmA"
                     /locus_tag="ACL8AS_000818"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000179 - rRNA
                     (adenine-N6,N6-)-dimethyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HGS1228708.1"
                     /translation="MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEI
                     DDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLVPILVDTLRDFDNVTVVNEDIL
                     KVDLAQHIQNFKNPNLPIKVVANLPYYITTPILMHLIESGIPFCEFVVMMQKEVADRI
                     SAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVED
                     ENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLA
                     EFAGLADALKGQGL"
     gene            complement(32301..32609)
                     /locus_tag="ACL8AS_000819"
     CDS             complement(32301..32609)
                     /locus_tag="ACL8AS_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228709.1"
                     /translation="MCEKIRIRRVSDYPSARGGLEDILIMENMTNHLLLVQIRVHGYL
                     LDFASIEGQRQKHYRLKNLPQTVELTVDDVEEDVDLTLPENRSYQEADFFERMFRENC
                     "
     gene            complement(32602..33243)
                     /locus_tag="ACL8AS_000820"
     CDS             complement(32602..33243)
                     /locus_tag="ACL8AS_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228710.1"
                     /translation="MIDIQGLEKKFNDRAIFSGLNLKLEKGKVYALIGKSGSGKTTLL
                     NILGKLEKIDGGRVLYQGKDLKTIPTREYFRDQMGYLFQNFGLLENQSIKENLDLGFV
                     GQKISKVERLERQVGALEKVNLGYLDLEQKIYTLSGGEAQRVALAKTILKNPPLILAD
                     EPTAALDPENSEEVMNLLVDLKDENRIIIIATHNPLVWNKADEIIDMRKLAHV"
     gene            complement(33245..35275)
                     /locus_tag="ACL8AS_000821"
     CDS             complement(33245..35275)
                     /locus_tag="ACL8AS_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HGS1228711.1"
                     /translation="MKRLFILISMVLVSLYMVITSVDHREEILFGNYPSVDVTGMMTN
                     QPVASREEVTEALSHLAVEHNSLIARRIVEPNEAGETRFTYATYGEGELPEGLTISSK
                     ESAETSDLLGSYLIVSGSLDGVSLQTTLKELGYQGFVSNGEDPFSIVLLLTATPMVLL
                     SLAIFLLTFMSLTLIYRIKSLRQAGIRLIAGESLFGVALRPVLEDVRQLICSVLVSSL
                     LGLGILWYQGALFMATVQLVIIALLLYGLTLAGISTLLSVVHLLGLQENSLVDLLKGK
                     LPLKRMMTLMMVGQLLAVLVVGSSATALLPHYREMQEMERASNKWSQSSDRYRLSFGW
                     SSAFADEEGTRKDNREWQTFTEERLANTDSFYIMSNVDNFSDGAEVDLDGNRLSDYTP
                     SGNVIYVSPRYLIEEKITVSSEFMDKMQNLSEGEFGLILPESLREQSVYYQGLFTDYL
                     QNFSSESVEVTSQKHYLPQVRLAFTETGQERFLYNDGYKTTRQYLKDPIIVVLTPQAT
                     GTRPVAGMLWGTTANSALKLDRYGDSITALKEQGLYHKVSYLVKSQLFFAKVLNDKRV
                     EFYSLLIGTILTLSTAILLFDSMNLLYFEQFRRELMIKRLAGMTIYELHGKYLLAQGG
                     VLLLGLVLSSILTRDGLISALVVALFTLNALLILVRQDKKEEAGSMAVLKGK"
     gene            complement(35352..35648)
                     /locus_tag="ACL8AS_000822"
     CDS             complement(35352..35648)
                     /locus_tag="ACL8AS_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HGS1228712.1"
                     /translation="MKQTVKKLALVASIAATLGGSVAVASAAVQYPEGGVWTYGSGNG
                     GAYSNYYHPSKYHSSTVVSRKTGSSDKGYAGAGGTSRAWIRTSWGEKVAFYYNV"
     gene            complement(35968..36867)
                     /locus_tag="ACL8AS_000823"
     CDS             complement(35968..36867)
                     /locus_tag="ACL8AS_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HGS1228713.1"
                     /translation="MLIGQKIKEIRIEKGVSRPDFCGDEQELTVRQLSRIESGASQPS
                     LPKLAYIARRLGVPVYSLMPDFSALPPAYLELKYQILREPIYGKEEEYDKKEACLEEI
                     YKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMSQIIEKEVYSTNDMLL
                     IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTKLENFFIIRDTLISGMCCLEKVG
                     VTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQ
                     LIGDEFLVKKLTEEWQEDVKKYL"
     gene            complement(36939..37499)
                     /gene="rnmV"
                     /locus_tag="ACL8AS_000824"
     CDS             complement(36939..37499)
                     /gene="rnmV"
                     /locus_tag="ACL8AS_000824"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043822 - ribonuclease M5 activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HGS1228714.1"
                     /translation="MKEKISQVIVVEGRDDTVNLKRYFDVETYETRGSAINDQDIERI
                     QRLHQRHGVIVFTDPDFNGERIRRMIMTVIPTVQHAFLKRDEAVPKSKTKGRSLGIEH
                     ASYEDLKTALAQVTEQFEHESQFDISRSDLIRLGFLVGADSRKRREYLGETLRIGYSN
                     GKQLLKRLELFGVTLAEVEEAMKSYE"
     gene            complement(37499..38272)
                     /locus_tag="ACL8AS_000825"
     CDS             complement(37499..38272)
                     /locus_tag="ACL8AS_000825"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HGS1228715.1"
                     /translation="MIFDTHTHLNVEEFAGREAEEIALAAEMGVTQMNIVGFDKPTIE
                     RALELVDEYEQLYATIGWHPTEAGTYTEEVEAYLLDKLKHPKVVALGEIGLDYHWMTA
                     PKEVQEQVFRRQIQLSKDLDLPFVVHTRDALEDTYEIIKSEGVGPRGGIMHSFSGTLE
                     WAEKFVDLGMTISFSGVVTFKKATDLQEAAKELPLDKMLVETDAPYLAPVPKRGRENK
                     TAYTRYVVDFIADLRGMTTEELAVATTANAERIFGLDSK"
     gene            complement(38568..39329)
                     /locus_tag="ACL8AS_000826"
     CDS             complement(38568..39329)
                     /locus_tag="ACL8AS_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
                     /protein_id="HGS1228716.1"
                     /translation="MCPVIVSFCYKVEVAGDGTATITFPDGSVVTILGKDTVQQSAKG
                     ESVTQEATPEYKPETTLGVDKGGNTGSSDANANAGGGSQAGGPAHTGSQNSAQSQASK
                     QLATEKESAKNAIEKAAKDKQDEIKGAPLSDKEKAELLARVEAEKQAALKEIENTKTM
                     EDVKEAETIGVQAIAMVTVLKRPVAPNAAPKTTSAPQATAGTMQDVTYQSPAGKQLPN
                     TGSASSAALASLGLVAATSGFALLGRKTRRRKWNS"
     gene            complement(39505..39639)
                     /gene="rpmH"
                     /locus_tag="ACL8AS_000827"
     CDS             complement(39505..39639)
                     /gene="rpmH"
                     /locus_tag="ACL8AS_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HGS1228717.1"
                     /translation="MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
                     "
     gene            complement(39784..40998)
                     /locus_tag="ACL8AS_000828"
     CDS             complement(39784..40998)
                     /locus_tag="ACL8AS_000828"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HGS1228718.1"
                     /translation="MKEYNKSSKLEHVAYDIRGPVLEEAMRMRANGEKILRLNTGNPA
                     EFGFTAPDEVIHDLIMNARDSEGYSNSKGIFSARKAIMQYCQLKKFPNVDIDDIYLGN
                     GVSELIVMSMQGLLDNGDEVLVPMPDYPLWTAAVSLAGGNAVHYICDEAVEWYPDIDD
                     IKSKITSNTKAIVLINPNNPTGALYPKELLLEIIEIARQNDLIIFADEIYDRMVMDGH
                     VHTPVASLASDVFCVSMNGLSKSHRIAGFRVGWMVLSGPKTHVKGYIEGLNMLSNMRL
                     CSNVLAQQVVQTSLGGHQSVDELLLPGGRIYEQRNFIYNAIQDIPGLSAVKPKAGLYI
                     FPKIDRNMYRIDDDEQFVLDFLKQEKVLLVHGRGFNWQEPDHFRIVYLPRVDELAQIQ
                     EKMTRFLKQYRR"
     gene            complement(41154..41446)
                     /locus_tag="ACL8AS_000829"
                     /pseudo
     CDS             complement(41154..41446)
                     /locus_tag="ACL8AS_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014348.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            41608..42060
                     /locus_tag="ACL8AS_000830"
     CDS             41608..42060
                     /locus_tag="ACL8AS_000830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HGS1228719.1"
                     /translation="MAQRYQNIMVAIDGSKEADLAFVKGVHSALRNDAKLTIAHVIDT
                     RALQSVSTFDAEVYEELQVDAESLMKEYEKRAKDAGVADVHIVIEMGNPKTLLARTIP
                     DAEEVDLILVGATGLNAFERLLVGSSSEYILRHAKVDLLVVREQEKTL"
     gene            complement(42095..43483)
                     /locus_tag="ACL8AS_000831"
     CDS             complement(42095..43483)
                     /locus_tag="ACL8AS_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HGS1228720.1"
                     /translation="MEVKAVFFDIDGTLVNNRKSVLKSTKDAIKIVKEQGVLVGVATG
                     RGPFFVKELMDDLDLDFAVTYNGQYIFSKDRVLFTSPISKLHLRHLISYAKKEGTEIA
                     LGTKDAMLGSKIMSFGLGSFSQRISRFVPSVLTRTVSQSFNRMVSKVVPQKEEDLLHL
                     MNQPIYQVLMLMTPEESEKAAADFEDLKLTRSNPFASDVINQGNSKLEGIRRVGKEYG
                     FDLNQVMAFGDSDNDLEMLAGVGMSVAMGNGSSSVKEAAKHITTSNQQDGIHKALEHF
                     GVLSSEKVFVSRDYHFNKVKTFHHMMDERTQEEPRAWDLEGATHRAGFKIEELVEFVR
                     AASPSEEDFGQAVSQLHQTLDKAADKVAKKTPAQQDLIGQVDALIDTLYFTYGSFVLM
                     GVDPERIFDIVHQANMGKIFPDGKAHFDPVTHKILKPDNWEEKYAPEPAIKKELQRQL
                     KAYERHKERNKS"
     gene            43549..44511
                     /locus_tag="ACL8AS_000832"
     CDS             43549..44511
                     /locus_tag="ACL8AS_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HGS1228721.1"
                     /translation="MPKKILVLHTGGTISMQADASGAVVTSSDNPMNHVSNPLEGIQV
                     HALDFFNLPSPHIKPKHMLVLYQKIKEEADNYDGVVITHGTDTLEETAYFLDTMEVPH
                     MPIVLTGAMRSSNELGSDGVYNYLSALRVASDDRAADKGVLVVMNDEIHAAKYVTKTH
                     TTNVNTFQTPTHGPLGLIMKQEILYFKTAEPRVRFDLDHIQGLVPIISAYAGMTDELI
                     DMLDLEHLDGLIIQAFGAGNIPKETAQKLESLLQKGIPVALVSRCFNGIAEPVYAYQG
                     GGVQLQKAGVFFVKELNAQKARLKLLIALNAGLTGQALKDYMEG"
     gene            complement(44540..44788)
                     /locus_tag="ACL8AS_000833"
     CDS             complement(44540..44788)
                     /locus_tag="ACL8AS_000833"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228722.1"
                     /translation="MNTIERTRRLVKGCATHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     SKHVFEVVDRTDEVSSKHVFEVVDRTDEVSNHTYGKAT"
     gene            complement(44852..45862)
                     /gene="ccpA"
                     /locus_tag="ACL8AS_000834"
     CDS             complement(44852..45862)
                     /gene="ccpA"
                     /locus_tag="ACL8AS_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0001228 - DNA-binding transcription
                     activator activity, RNA polymerase II-specific [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="catabolite control protein A"
                     /protein_id="HGS1228723.1"
                     /translation="MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANS
                     DEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPS
                     VNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGIAYSEGL
                     VFESKYSYDDGYALAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSD
                     DSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRK
                     RK"
     gene            complement(46287..46886)
                     /locus_tag="ACL8AS_000835"
     CDS             complement(46287..46886)
                     /locus_tag="ACL8AS_000835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HGS1228724.1"
                     /translation="MKVLVAEDQSMLRDAMCQLLTLQPDVESVLQAKNGQEAIQLLEK
                     ESVDIAILDVEMPVKTGLEVLEWIRSERLETKVVVVTTFKRAGYFERAVKAGVDAYVL
                     KERSVADLMQTLHTVLEGRKEYSPELMEVVMTRPNPLTEQEIAVLKGIARGLSNQEIA
                     DQLYLSNGTIRNYVTNILSKLDAGNRTEAANIAKESGWL"
     gene            complement(46888..47985)
                     /locus_tag="ACL8AS_000836"
     CDS             complement(46888..47985)
                     /locus_tag="ACL8AS_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HGS1228725.1"
                     /translation="MLERLKSIHYMFWTSLIFMLFPILPVVIGELPAWHLLVDILFVV
                     TYLGVLITKNQRLSWLFWGIMLVYVAGNTAFVAGNYIWFFFFLSNILIYHFGVRSLKS
                     LHVWTFLLAQVLVVGRLLIFQRIEVEFLVYMLVILTFVDLMTLGSVRIRLVEDLKEAQ
                     VKQNTQINLLLAENERNRIGQDLHDSLGHTFAMLSVKIDLALQLFQMQAYPQVEKELR
                     EIQQISKESMREVRTIVENLKSRTLTSELETVKKMLEIAGIEVETDNQLDTASLTQEL
                     ESMASMILLELVTNIIKHAKASKAYLKLERTEKELILTVSDDGCGFAFLKGDELHTIR
                     DRVFPFSGEVSVISQKHPTEVQVRLPYKERN"
     gene            complement(47985..48722)
                     /locus_tag="ACL8AS_000837"
     CDS             complement(47985..48722)
                     /locus_tag="ACL8AS_000837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1228726.1"
                     /translation="MKRWIALSKIEFLLTKRQLIYYLLSVGMPTAFYLFFSGIYQDTP
                     GEPANFMRDYLISMTAFSMMSTTIFSFPAVLHTDKMNNWQKTLRHSPVNMVEYYLSKI
                     TSMLVDYLVSILVVFTVGHFVRGVDMPLVKWVGAAILLIVGSIAFVALGLTLTLLPTS
                     QLMSVVGNLLYLGLAVLGGLWMPISLFPDWMQAVGKCLPTYQLMELLKTFLNEGGINL
                     SATVYLLVFSAVLFGLTIYLQGHKENA"
     gene            complement(48724..49608)
                     /locus_tag="ACL8AS_000838"
     CDS             complement(48724..49608)
                     /locus_tag="ACL8AS_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228727.1"
                     /translation="MTVVKVEKLSKKIKDKEILRNISFEINDGECVALIGPNGAGKTT
                     LLDCLLGDKLVTSGQVSIQGLPVTSSKLDYTRAYLPQENVIVQKLKVKELIAFFQRIY
                     PNPLSNQEIDQLLQFVKQQKEQLAEKLSGGQKRLFSFVLTLIGRPKIVFLDEPTASMD
                     TSTRQRFWEIVQELKAQGVTILYSSHYIEEVEHTADRILLLNKGELIRDTTPLAMRSE
                     EIEKHFILPIAYKEVVEQSNLVENWTLKQDSLQVVTREADAFWELLAQAGCRMQEIEV
                     NNRSLLNTIFEETQKGDN"
     gene            complement(49595..49789)
                     /locus_tag="ACL8AS_000839"
     CDS             complement(49595..49789)
                     /locus_tag="ACL8AS_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228728.1"
                     /translation="MKRGIIYFFIGLSLLVWLVEMFTDWFDQALLRQFIRGALGFGFM
                     IFVVFLMGMEWLKGESHDGG"
     gene            complement(49786..49992)
                     /locus_tag="ACL8AS_000840"
     CDS             complement(49786..49992)
                     /locus_tag="ACL8AS_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228729.1"
                     /translation="MGEEEMRNKMIIAVSLVVAGVMTYLMFSGLDEDFYHFPWKVFAG
                     FGIMSWLVREGLKLVRDVKKEFEE"
BASE COUNT        14621 a        11473 c         9623 g        14857 t
ORIGIN      
        1 ctttgttcac aaattccttc tgcaagagtt tgttgggaga gtcctagctc ttttcttttt
       61 aatctgaatt tctctgcgag tgtattcatt aaagataata aaccttccta tttgcttaat
      121 ttcattataa aatttttagt tcaaaatagt aagttaaaga aacaaataat tctttatggt
      181 aataaataaa aaaagtcaaa aattacataa aaatacttga ccgaataata tatatatgtt
      241 aaaataaaaa caaggaaaaa gaaaggggtt tcacgaatga agaaaaatcg tggaattcaa
      301 aaattagcta tattagtatt actaggtgtt tttatgttta gtaacacaat tccttaccaa
      361 cagttattca gaagaataga caattggaga ttcgagtgca atcacaaaag aagtccaatg
      421 gtcttgatgt tgggaaggct gattgatttc gtattacttt aaaattcaac tatttagaga
      481 aaggtattct gatgagagct tgtaacaata ccagatagat ataagaatgg agatgtttga
      541 taaaatgctt tcatagctaa ccaactgttg aaaattatga gttacaaaat ctaaagtatt
      601 taagattggt ttataaaatt aggtctctgc ctgtagaaag gaacgtgcag ttagaaagga
      661 ggaaaaaata ggatactata attcagactg agatttctaa ttaaaatatg tagttgcatt
      721 tcgctcattt tcataatatt tcatttagag gagtaataat atgttaaaat ttagaaaagt
      781 agttgcatca tcccttgccg ttttggcatt tagtttggct cttcctgttt tggcagtttc
      841 tcaccgtggt ggcgagtgga cctatggagg ccatcatgat ccatataatt ggggagcatt
      901 ttcgaattat tatcatggtt cacagtatca ctgggcctat gttggaagta atgaacgtga
      961 caatcaaaaa acagtttatg caggagcaca tagtgcggcc tatgcgtttg ttaatacaaa
     1021 tttgggggag cgaattacat ttgatgcggg atggtaaaga ataattgaag aagattcttt
     1081 tatcaatagt ttagtaagct tgttagttta tagagggcag gggtatttct gccctctgtt
     1141 ttagaataag gaatgcacta tgaaaaaatt atttatactc atatccaacc tgcttgctag
     1201 tttgttcttt gtttgggtat ttaccatttg gactgataca tatgtctccc attattaccc
     1261 caacgttgtt gtacatgatt cttcccctga aacaactttt cagcatgttg ctacacgctt
     1321 ggaaaaacta gcagaagaaa cagatagctt tattgcgatt caacaccaag atcctaactc
     1381 agaaggtact acagtttttt cttatacgac ctttggagac ggaaagttgc ctgacgggct
     1441 acaggaaaaa aaactagaag atgctcaaag tagtagtgtt gaaacaaact attttgtatt
     1501 cgatggacac ctagatattc acttgctaag ggaggagcta agtcaacttg gcttgactaa
     1561 tatgcacctg acaattccat ctaaactatc tacgttaatg gctatcttta gtaacggatt
     1621 tcagttaatc agtctattga ttttcatctt aacctttgga gcactgactt taattagtca
     1681 aattagccaa ttacggtcgt cgggcattcg cctcatttca ggagagaaac ggtggtccat
     1741 ttttcttaga ccagttggtg aggatttgaa agggatagct gttggtttca gtttagctgg
     1801 cgtgctcacc attcttatgc aaaaaattct gtcgcttcca acgcaatccc taatgaccat
     1861 aggagcaggc ttgctcagtt ataatctcat cttgttgtct atctccctgt ttttcgctca
     1921 actcttcgca gttgggataa aaaagataca cctgatgcag attataaaag ggcaagtgcc
     1981 tgtcagagga atcattagtt tgattttaat cggtcaacta ttagcgatta ttattgtaac
     2041 actgggaata gggagtagct taaagtattc ccaagcctgg caacagcatc ggattggaca
     2101 agaggcttgg agccaggaaa ggcaactgat taccctatca atcagccgtg aaggaacgag
     2161 tcctggtttt gatgaacaag ctcaaaggaa actcagaact tggtatcaat tgatggatct
     2221 ggctgtttca gaacaaaagg ctttcttatc tagacaccag ttaattgacc gtactttgca
     2281 aaatggcatg gcttcctcca aaaactttat aacctctaca gaatggcacg attacagccc
     2341 gaatggcaat gtccttatcg tcacaccgca atacttggag cgtcaaaaca ttcctgtaga
     2401 tacaactatt gagcaaaaga tgaatcacct tgatgtaggg gagtttgtct tattgctgcc
     2461 tgaacacctc cgttcagagg aagatcatta taaatctgtt tttgaagacg acttaaccag
     2521 tcgcatgtct agtcaagatg aacgacagca aatgactgct acggtaggtt atttagaatc
     2581 aggtcaggat cgttttgtgt ataatacgac ccctatttct taccagcagt ttttgaaaga
     2641 tccaatcatc attgttataa caccccaatc aactggtcca cagtccattt tgttttggat
     2701 agacgcagta cagaactacg ttctctttaa tcaattgtct gatgcccagg agcttatcca
     2761 gagacaaggc attgaaaatt gggtctcaga aatgcaaaca ggttaccaca actacatcac
     2821 attattggat aatatccaga gggaacgttg ggtaatgcta gcaggagctg tgcttgggat
     2881 tgcaacttca atcttgctgt ttaacactat gaataggctc tactttgaag aatttagacg
     2941 tgccattttt atcaaacgca ttgcaggtct caggttctta gaaatccatc gcacttatct
     3001 ctttgctcaa ctgggtgtgt ttttactggg atttgttgct agtgtatttc ttcaggtaga
     3061 aataggagtt gctttcttag tcttgttact ctttactggt ctatctcttt tacagttaca
     3121 tgtccaaatg cagaaagaaa acaagatgtc catgcttgtt ttgaagggag gttaatatga
     3181 ttgaacttaa acaggtgagt aaatcttttg gagaacgaga gttattttcg aatctttcaa
     3241 tgacatttga ggctggaaaa gtctatgcct taattggttc aagtggtagc ggaaaaacaa
     3301 ccttgatgaa catgattggg aaattagaac cttatgatgg gacgattttt taccgaggta
     3361 aagacttggc caattataaa tcgagtgatt ttttccgtca cgaattgggc tacctcttcc
     3421 agaactttgg cttaattgaa aaccaaagta ttgaagaaaa ccttaagcta ggtctcattg
     3481 gtcaaaagtt gagtcggtcg gaacagcggt tgaggcagaa gcaggcttta gaacaggtcg
     3541 gcctggctta tcttgaccta gataagcgca tctttgagtt atcgggcgga gaatcgcaac
     3601 gagttgcctt ggcaaaaatt atcttaaaga atccaccctt tattctggca gatgagccaa
     3661 cagcttcaat agacccagca acctctcagt tgattatgga gattttgcta tctcttcgag
     3721 atgataatag gctaatcatt atcgcaacac ataatccggc aatttgggag atggctgatg
     3781 aagtgttcac gatggatcat ctgaaataaa aatccttgtt tttaattgca cgatgagtta
     3841 ctgaaatatt atcatgaatc aagaattgga gttaatttag aattgtactt tattaatatt
     3901 gaggtaactt tttcttgata aaggaggaaa tagtggagag gaagttagaa tgaaaaaatt
     3961 cgacaattat attattgaga agccttgcga ttctaattca gataaactgc aaaaaatctt
     4021 aataattgaa aatttggtag atgatatttt gcaatttcct ctcagaatca ataatagtgt
     4081 aggagagatt ttcctcctac aaccgtttca aaagaaaact atctttattc catgttattt
     4141 tgaggaagat attgtgaaag tcaaagatga tgataaagtt gagtggaatt tgttagaatt
     4201 tcaaaaattt agagcatttt tggcttagta atctgtgttg aaggctcaaa acctatggta
     4261 aaaaagtcgc tttgaaaacg tattgcctcc aaagatttag ttaaataatg atttaacaca
     4321 aaaagaaatt attgaagttc tggaaagatg ttgtttcagt attgagaaaa ggtgggaaaa
     4381 acttgcgatt ttcacagaga aaggaagaaa aagtatagaa atatagtcaa ttgaaacaag
     4441 aacaggacaa aagaaccttt tgtgccatat ttttctcctt tcgctttaca attggcttga
     4501 acacctttat tgtatcgcgt ttggagtttt tttggtataa ccttcgacgc gcacccgcat
     4561 agcgggtgtt tttttgtctc gcacctaacg gagcgagacg aactaatagt cacttaatca
     4621 aaaaaacgca ccatatcaaa aactaaaaag tttgatatca tgcgtcatgt cttaaactaa
     4681 ttgactatac tttctattca aatgagcttt taaccaattg attgagccaa tccactctta
     4741 aaaccaaaga gcaatttctc gcttagctga ctcttctgaa tctgaaccat gtacaacatt
     4801 ttggataacc tcattttctc cagcagcttt tgcaaagtca cctcgaatag tgcctggtaa
     4861 agcttcttct ggacgagttg cacccatcat ggtccgccaa gtttcgatta ctttgggacc
     4921 agaaatgaca cccacaagaa ctggacctga agtcatgaat tcacgaatcg gtaggtaaaa
     4981 actctgacca accaagtcct gatagtgctg gtcaatcaac tcttctgaaa cctgtgaacg
     5041 aaactccaat ttttcgattg taaatccacg ttgttcgatg cgctttaaca cttcacccac
     5101 tagccctctt tttacaccat ctggtttgat gataaagaat gtttgttcca tacccgtctc
     5161 ctttgtcagc ttctttcttt tattttacca catttcgtgg aaaaatggag aaagttttca
     5221 gaagagagaa tgagagaacc cgagggttct ctcattctct cttattctac tgtttcttcc
     5281 acagtttcaa cggcagtatc cacaactact tctgttgttt cttcatttcc ttcttcctct
     5341 actgtaggat taaggtattc ttcttcgttg acagcatgtg gttcaaggtt acggtaacgg
     5401 gccataccag taccagctgg gatgatctta ccgatgataa cattttcttt aagtccaagg
     5461 agatggtctt tcttaccacg gatagctgcg tcagtaagga cacgagttgt ttcttggaag
     5521 gaagctgctg acaagaaact gtttgtttca agtgaggctt tggtaattcc cataaggact
     5581 gggcgacctg tcgctggaac tccacctgcg ataaggacat ctttgttggc atctgtaaag
     5641 tcattgatat ccatgagggt acccatgaga agatctgtat cacctggatc catgacacgg
     5701 actttacgga tcatttgacg aaccattacc tcgatgtgtt tgtcaccgat ttctacccct
     5761 tggctacggt aaactttttg tacttcaccg agaaggtacg tttcaactga caagacatca
     5821 cgaactgcaa ggagacgttt tggttggata gaaccttctg tcagagcagc accacgcgct
     5881 acttggcccc caacttcgac acgcatacga gctgtaaatg gaacgacata ttcaccttcg
     5941 ccagtttcac ccttaacaaa gactttcttg gtacgagttg atgcatcttc ttcgatagca
     6001 gtaacttgtc ctttaacctc tgtgataacc gcttcccctt taggattacg ggcttcaaag
     6061 atttcttgga cacgaggaag accctgagtg atatcggtat ttgaggcaac cccacctgtg
     6121 tggaaggtac gcattgtaag ctgtgtacca ggttccccga tagattgggc agcaattgta
     6181 ccaactgctt caccaacttc aaccgcatca ccagtcgcca agttgatacc gtaacagtga
     6241 cggcagacac cgtgacgagt gttacatgta aatacagaac ggatagtcac ttcttccaca
     6301 ccagcattga caatttcacg cgccttgtct tctgtaatca attcatttgg accaataatc
     6361 actgcaccag tttctggatg tttaacagtt ttcttagtgt aacgaccgtt gagacgctct
     6421 tcgagagact cgatcatctc ttttccttct gcgatagaac ggatcaagag accacggtca
     6481 gttccacagt cgtcctcacg gatgataacg tcttgggcaa cgtcgaccaa acgacgagtc
     6541 aagtaacctg agtcggctgt cttaagggcc gtatcggtca tacctttacg agcaccgtga
     6601 gttgagaaga acatttccaa taccgacaaa ccttcgcgga agtttgaaag gattggcaat
     6661 tccatgatac gtccattcgg agcagccatc agaccacgca taccggcaag ctgtgagaag
     6721 tttgagatgt taccacgggc tccagagtcc atcatcataa cgattgggtt cttaggatct
     6781 tggttagcaa tcaagcgttt ctcaagtttt tcacgggcag cacgccattc agctgtaaca
     6841 gcattgtaac gctcgtcgtc tgtgatcata ccacgacgga attgtttggt gatttgttcg
     6901 acacgtttgt gtgattcttc aatgatttca gtcttgtcat caacgactgg gatatcggca
     6961 atacccactg tcaatcctgc aagagttgag tggtggtaac cgaggttctt catgcggtca
     7021 agtagggcag aagtttctgt cgtacggaaa cgtttgaaga tttcagcgat gatatttcca
     7081 aggtttttct tcttgaatgg agggttgagc tcaagattgc tgatagcttc cttgatatct
     7141 ccaccaagtg gcaagaagta tttagctgga acaccttctg tcaagttggc attgtttggt
     7201 tcttgcaagt atggtagccc ctctggcatg atatcgttga agagaatttt accaactgtt
     7261 gtaagcaaga ccttatgtct ttgctcttct gtccaaggct tgttgaggct gtctgttgcg
     7321 ataccaacac gtgagtggag gtgaacataa ccattgcggt aagccataac cgcttcgtca
     7381 cggtctttga agaccattcc ttcaccttcg cgaccagctt cttccatggt caagtagtag
     7441 ttacccaaaa ccatgtcctg agatggagta actaccggtt tcccatcttt cgggttcaag
     7501 atgtgctcag cagctagcat gaggatacga gcttctgctt gtgcttcttc tgaaagtggt
     7561 acgtggatgg ccatttggtc cccgtcaaag tcagcattgt aggcttcaca gacaagtggg
     7621 tgcaagcgaa gagccttacc atcaattaag actggctcga aggcttggat acccaaacgg
     7681 tgaagggtcg gtgcgcggtt caaaagcact gggtgttctt taatcacttc ttcaaggata
     7741 tcccagatac gctcatctcc gcgttccacc aagcgtttag ctgctttgac gttttgcacg
     7801 atatcacggg caacgatttc acgcataaca aatggtttaa agagttcaat cgccatttca
     7861 cgtggcacac cacattggta catcttaaga gttggaccaa cggcgataac ggaacgtcct
     7921 gagaagtcaa cacgtttacc gagcaagttt tgacggaagc gtccttgttt acctttaagc
     7981 atgtggctca atgatttcaa tggacggcta cctggtcctg tgattggacg accacgacga
     8041 ccattgtcaa tcaaagcgtc aactgcttct tgaagcatac gcttctcatt ttgaacgatg
     8101 atacctggtg catttaactc aagcaaacga gccaaacggt tgttacggtt gataacacgg
     8161 cggtaaaggt cattcaagtc agatgaggca aaacggccac catccaactg caacattgga
     8221 cgaagatctg gtgggataac cggaaggatg ttaagaatca tccattcagg tttgtttcca
     8281 gacttgtaaa aggcatccaa aacatccaaa cgacggatgg ctttgacacg tttttgtcca
     8341 gtagctgttt tcaattcttc tttgagttca gcaatttctt tttcaagatc tacttgcttc
     8401 aaaaggtctt ggatggcttc cgcacccatc ttggcaacaa atgaaccata accatattca
     8461 cgcaagcgct ctcggtattc gcgctctgtc atgatagact tgtgctcaag tggtgtatcc
     8521 ttaggatcaa tcaccacata agccgcaaag tagataactt cctcgagggc acgagggctc
     8581 atatcaaggg tcaagcccat acggcttgga atccccttga agtaccagat gtgagataca
     8641 ggagctttca attcgatatg tcccatacgc tcacgacgaa ctttcgtacg cgttacttca
     8701 accccacagc ggtcacaaac aattcctctg taacgaatgc gtttgtactt accacaagca
     8761 cattcccagt cttttgtagg accaaagatc acttcatcaa agagtccttc acgttctggt
     8821 ttcaaggtac ggtaattgat tgtttcaggt tttttgactt ctccataaga ccatgaacgg
     8881 actttacttg gagaagctag ggtgatttgc atacttttaa aacgatttgc atcaaccact
     8941 atttcttccc tttctattct aagtgaactg cttattcttg ttcagcagct tcttctgttg
     9001 cttccgcttt tgttgctttc tcagcttctt cagcttcaaa ggctgcttta gcctcttggg
     9061 ctgctttttc gcgggctttt tcaaggtcat ctacgtggat gacatcttcg tccattcctt
     9121 catccaagtc gcgaagttcc acttcttggt catcttcgtc taggacacgc atgtcaagac
     9181 caagagattg caattctttg acaagaactc ggaaggattc tggaacacct ggttttggaa
     9241 ttggtttgcc ttttgtaata gcttcatagg ctttcaaacg tccgttgata tcgtcagact
     9301 tgtaagtcaa gatttcttga aggacatttg acgcaccgta ggcttcaaga gcccaaacct
     9361 ccatctcacc gaaacgttgt ccaccaaact gagctttacc tccgagtggt tgttgggtaa
     9421 cagttgagta aggtccgact gaacgcgcgt gcaatttatc gtcaaccatg tggtggagtt
     9481 tgatcatgta catgactcca acagaaacac ggttatcaaa tggttcacca gtacgtccat
     9541 cgtaaaggat cgttttggca tcgctatcca tacctgcttc tttaacagtt gaccaaagat
     9601 cttcagaact tgctccatca aagactggtg tcgcaatgtg aataccaaga gtacgagctg
     9661 ccataccaag gtgaagctcc ataacctgac cgatattcat acgtgatggc accccaagtg
     9721 ggttcaacat gatgtcgact ggagttccgt ctggaaggta aggcatgtct tctacaggaa
     9781 cgatacgaga gacaacccct ttgtttccgt gacgtccggc cattttatct ccgaccttaa
     9841 tcttacgttt ttgagcgatg taaacacgaa ccaacatgtt aacacctgat tgcaactcat
     9901 ctccatttac acgtgtaaag atcttaacat cacgaacgac accatcggca ccgtgtggta
     9961 cacgaagaga agtatcacgc acttcacgag acttgtctcc aaagatagcg tgcaagagac
    10021 gttcttcagc tgaaagatct ttctcaccct taggtgttac tttacctaca agaatatcac
    10081 cttctttaac ctcagcacca atacggataa tccccatttc gtcaaggtct ttgagggcat
    10141 cttcaccaac gtttggaatt tcgcgagtga tttcttcagg cccaagcttt gtatcgcgcg
    10201 tttctgattc gtattcttca aggtgaacag atgtgtagac atcgtccttc accaagcgtt
    10261 cgctcatgat aacggcatcc tcgaagttgt aaccttccca agtcatgtag gcaacgattg
    10321 ggttttgtcc aagcgccatt tctccatttt ccatagaagg tccgtcagcg atgaaatcgc
    10381 ctttttcaac gacatcacca acttttacga gagtgcgttg gttgtaagca gtacctgagt
    10441 ttgaacgacg gaatttttgg atgtggtaaa catccaatga accatcttca cgacgaactt
    10501 ctaccttgtc agcatctgcg taagtaactt taccatcata ctgagcaatc acagccgcac
    10561 cagaatcgtg ggctgcttgg tattccatac cagtaccaac gtaaggtgcc tgaggattaa
    10621 tcaatggcac agcctgacgt tgcatattgg ctcccatgag ggcacggttg gagtcatcgt
    10681 tttccaagaa aggaatacat gctgtcgcaa cggcaactac ctgttttggt gaaacgtcca
    10741 tgtagtcaac aatattagct ggatactctt ggttgacccc ttggtgacgt cccatgacaa
    10801 tcttctcagc aaaggttcca tcttcattca gacgagagtt agcctgagct acagtatatt
    10861 catcttcttc atcagctgtc aaccaaacaa tttcgttcgt gacaacacct gtttcacggt
    10921 caaccttacg gtatggtgtt tgaacaaaac catatttgtt caagtgtccg taagatgaca
    10981 agttattgat caaaccgatg ttaggtcctt caggtgtctc gattggacac atacgaccat
    11041 agtgagtgta gtgcacgtca cgtacttcat atccggcacg gtcacgagtc aaaccaccag
    11101 gtcctaaggc tgacaaacgg cgtttgtgag acaactcaga aagcgggttg tgttggtcca
    11161 tgaactgtga caactgtgat gaaccaaaga attctttaac tgcagctgtt acaggacgga
    11221 tattgataat ttgttgtggt gtcaagactt cattgtcctg aacagacata cgttcacgga
    11281 cattacgttc catacgagaa agtcccaaac gtacttggtt ggcaagcaat tcaccaaccg
    11341 cacggatacg acgatttcca aggtggtcga tatcatctac acggccaagt ccttcagcca
    11401 agttgaggaa gtagctcatc tcggcaagga tatctgcagg agtcaccgta cgaaccttgt
    11461 catctgggtt agcattacca atgatcgtta cgacgcgatc tggatcagtt ggagcaacaa
    11521 ccttgaattt ttgaagaaca acaggctcag tcacaacggc tgcatcgttt gggatgtaga
    11581 caatcttgtt caagtcgcca tccaaatggc tttcaatgct ttcaatcacg ctacgagtca
    11641 taatcgtacc agcttctacc aagatttctc cagtttcagg gtctaccaat ggctctgcaa
    11701 tggtttggtt gagcaaacgt gttttaacat tgagtttttt attgattttg taacgaccaa
    11761 ctgctgccaa gtcatagcga cgtgggtcaa agaagcgagc cacaagcaag ctacgtgagc
    11821 tttcagctgt cttaggctca cctggacgaa ggcgttcgta aatttctttc aaggcttcgt
    11881 ctgtacgaga gtccattgga ttcttgtgga tatctttttc aacagtgttg cgaaccaatt
    11941 cgctgtcacc aaagatatca aagatttcat catcacctga gaaaccaaga gcacgaacca
    12001 aggttgtaaa tggaatctta cgagtacggt cgatacgagt gtaggtgata tcttttgagt
    12061 cgctttcaag ttccaaccaa gctccacggt tagggataac agttgaacca tagcccacct
    12121 taccattttt gtctactttg tcgttaaagt aaacacctgg tgagcggacc aactgagaaa
    12181 cgataatacg ttcaccacca ttgatgatga aagtacccat ttctgtcatg attgggaaat
    12241 caccaaagaa aacttcttgg gtcttgattt cgcctgtttc tttattgatc aaacggaagg
    12301 ttacaaaaat tggtgctgag tagctagcat cgtggatacg agcttcttct agcgtgtatt
    12361 ttggttcctt gatttcatat ccaacaaatt ccaactccat tgtgtctgtg aagtttgaaa
    12421 ttggcaatac atcttcaaac acttccttaa gaccgtggtc taggaaagct ttgaatgagt
    12481 cagtttgaat ttcaatcaaa tttggtaagt caagaacttc tttgattctt gaaaaactac
    12541 gacgggtacg atgtttcccg tattgaacgt catgtcctgc caagatgatt ctcctttgta
    12601 aataagttcc aagccttgtc aatcaggctt ttctaatcgc catatggttg taaacccctt
    12661 atcaccgtgt cctcttgacg aattttcaga atctttaagc ctctgttaca aatgctcaaa
    12721 atcttgaaaa aaagcacaaa aagagcagct aaatctgact ttttcagaag atttaactgc
    12781 tgtgagcctt gtctggacaa tatttcagac aaaacctacg acaaatgatt acccatatta
    12841 taccctattt agctagattt ttcaaggggt ttcagtaggt ttttggtaaa ttttttccca
    12901 tagaaaactt ggcatcacat tcgaatcacg ctatggtaca aaaaactgaa aaaactattg
    12961 actgaaaatc attttcaagg tataataata aacgttaagg cggtatagcc aagtggtaag
    13021 gcacggctct gcaaaagctt gatcgtcggt tcaaatccgt ctaccgcctt ctataacttg
    13081 atttatcagg tttcaaatga acagaaagcc caatttgaag ggcttttctt attttccctc
    13141 gaataaatac gtataacttt aaaaactttt ggagcgagtt tgtggcagag ttctttccat
    13201 ggcataattc ccttttgaaa tcaattgaaa aaagcttcgt cacgcctggt gacaaaagcc
    13261 tctagtttat tctgtttctt cttctatttc gacttctgtg atttggattt ttaccttggt
    13321 aacacgtcca ttcttcactt tatcattggt taagataaac tgtttgtttt ggctgatcaa
    13381 ttcatagctg agtttctcag tcgttggaat ggttcccact cctgtcaaat aataaccagc
    13441 gatagtatca acgtcatcac tttccagttc aacattaaag taattattga aatcattgag
    13501 ggtcatagtt ccttgaacaa tgtaggtatc ctcgccaatc tgataaacat ctattgctgc
    13561 tttgtccgtt tcatcatcaa tttcaccaac aatttcctct aagaggtctt ccaaagtcac
    13621 caaaccagcc ataccaccgt attcatccag caagattgcc atttgtcttt gggtatttcg
    13681 cagttctttt agcaagtcat ccacaaaaat agtttcaggt acaaaaagtg gatcttgtaa
    13741 aattctcttc caaacaatat tgtcaaaacc gtccacaaag cctgccttaa ggagactctt
    13801 ggtgtgaatg attccaatta cattgtcctt atccccatca taaaccggga tacgagaata
    13861 attttgtttt aaaatacttt ggataatggc ttgactatca tcctgaatat ccaccataaa
    13921 ggcatccgtt cgaggaacca taacctctcg tgccatcagt tcatcgagcg aaaagacacc
    13981 ttgtagcatc tcaatctcat cagcatccaa tgtttcttca ctatttgtca gcatataggc
    14041 aatttcatca cgggtcatct tttcatccgc atcatcgaat gacataggag tcaaatggct
    14101 caagaaattg gtcgaagcag ctaaaagcca aacaaaagga ctgactagtt ttccgatccc
    14161 aatgataacc ggcgctgtac gaattgccaa ggcatccttt agattaagag cgattctctt
    14221 aggatataat tccccaaaaa cgatggaaat ataggtcaaa aatgccaagg atagaaaagt
    14281 tgccacggct tgtgctgttt cgccattccc aagccaagag gcaatcacac gtcctagagt
    14341 atcagttaaa ctcgcccctg ataagattgt aatcagggtg attcctacct gaatggttga
    14401 taaaaagtgg ttaggatttt ctagtacctt cagcaggcgg atgtagcgtc tgtctccttc
    14461 ttccgccttt tgttcaactc gggcacgatt aagagaaacc atggccattt ctgtggctga
    14521 gaaaaaggca tttaataccg tcaagataaa caataaaaca aattgtagca acaaattctg
    14581 actacttggg tcttccatag ttcttctcct aaaatagtat cttatccttt attatatcac
    14641 aaaatttaat ccaatacata ttattttttt cttagcgtaa cttccatctc tctcccaaaa
    14701 ctggaagtta gtctaagacg gatttccact gatttcacgc gtttttctca tactaaaagc
    14761 taggttgtgg gaaactggaa gttagtttta gaagttgcta ttttttctta gtacctgttc
    14821 tagccctgct taaactagta aaaagaactc ctacatccat aagtgacata ggagtttagg
    14881 cttatctttt actgagttac agttacttct ccagttcggt aatccagttg aagtcccttt
    14941 tgaacattgg gaactagaac attgaattcc aattctccat ccgaagactt ggcttcaatc
    15001 tgtgaagctg agggaactaa atcctcgttt gaagcgtagt aaagggttac acggtaacgg
    15061 acacgcttgt tttggtccaa ggctttacgc accttgcttt catagtagtt ttgaccagtc
    15121 gaatactcgg cttgtgcctg atttgcccag gctgtctgaa cagcaatgtt tttaggattg
    15181 cttgttgagg catcaaaacc atccaaacca ccgattaagg catagcctaa caaatgacct
    15241 ctatcgactg catgggtata agagcccttt agattcttga cctgatgcca acctggagga
    15301 gtccaagaag ttgaaccatt cccagtttct ttacgattct tgtactgacg agtggcatta
    15361 gacaagaggg cattagctac ggttggaaca gtttccttgc ccactgtctt tgttttattg
    15421 tcagcgtagg gcttacttga aaccttggca tctagatttg ttttattacc attgacgata
    15481 aaagcacctg agccattcca ctccagactc ccctttattt gactcttgac tgcgtctgtt
    15541 aagacactct ctgccaatgc ttgactagga gcttcaggcg cttgtttttt ctgactaaga
    15601 ttggttttgg gactattagg tgccgactgc atctgcttga tataatagct ccctgtagac
    15661 aaaagcaata acactagcag tccgattagt gtctgtcttg tttttttgtt catatttctc
    15721 cttatcttta gaaaaaggct ggttctccag cctaatttcc tgtaaattta tgaatcaatt
    15781 cctgccattt tgctggagac aggatagccc atggatcttg acccttgccc aagattccat
    15841 aacctaccat tagaccgatt cctagagcca gagtacctaa aatcagtact atgatgacta
    15901 aaagtaaacg cttgactacg tagcttgatt tcttattcat cttcatcact tgcctcaatc
    15961 cgctgaatct tagcacctag ctgcgccaac ttctcatgga aaccgtagta acctctatcc
    16021 aagtgaacca atttaccgac cacagtttct ccctgtgcta ccaaacctgt caaaatcaaa
    16081 gctgcactgg cacgaaggtc agttgaaaga acttctgctc cctgcaaagg ctgtccacca
    16141 acaatacgag ctgtatcacg gataatctca gaatgcaagc ccatgcggcg catctcttct
    16201 aggtgttgga aacgattttc aaaaactgtc tccaccatgg ttgattcgcc ttttgcaact
    16261 gtcatcaagg ctgtaaattg agcctgcata tctgttggaa atcctgggtg gggcaaggtt
    16321 ttcacatgaa cagcttttag attttccagt tgagaacgaa cacgaattcc ttcgtcttct
    16381 tcaattactt caacacccat ttcaagtaac ttggcaatca agggacggtt gtgctcccag
    16441 acagcgtctc gaatcaagac atcaccacca gtcatggcag cagctaccat aaaggttcct
    16501 gcttcgatac ggtcctggac tacattgtga gtcgtaccat gaagtttctc aacaccagta
    16561 atggttatag tctctgtacc agcacctttg accttggctc ccatttcatt aaggagaatg
    16621 gctaagtcaa caatctcagg ctcacgcgca gcattctcaa tcactgtcac cccatcagcc
    16681 agagtcgctg ccatcatcaa gttctgcgtt gcaccaacac ttggaaagtc catatagata
    16741 tgagcaccat gcaagcgttc tgccttggct tcgatgtaac cagctgtctg actaatctta
    16801 acccccatag cttccagacc tttcaaatga agatcaatag gacggctacc aatcgtacaa
    16861 ccacctggca tggatacctt ggcatgaccc acacgggcaa ggattggccc taatacaacg
    16921 atggaggcgc gcatcttact gacatacttg taaggggctt cctcagtgat gtcgccagta
    16981 gcatccacct tgacaagatg agcttcctca tcaaagtcaa ccttggcatt caaaccacca
    17041 actacctgat tcataataaa gacatccgac aaaatcggaa cattctgcaa gacggtcttt
    17101 ccttcacttg ctagaatagt cgctgccaac aagggtaaga ctgcattttt tgctccctcg
    17161 atcgtcacgc ttcctaccag acgattatcg ccaccttgaa ccacaatttt atccatactc
    17221 gtttccttta ctcttgattt tataataatc ctctaagcgc ttcttgccac aaatgataca
    17281 ggctaataaa gaaagaactc aggatgtagc ctatgacaat gctaaaaaag gctactaata
    17341 cacgaacttt tcttgtattc tcagctgtca cttttaaaac cttttcccat ctaacaagat
    17401 cctttaaaag gtaaaaactc acataaataa agagcatatg actacttaga gtgaataata
    17461 attgaaccat ttgactatta taccatcttc tctgtttgtg cgctagtttg gaaacttcac
    17521 tcaaaaatta gggattgttt ttcaagtaat caatcgcatc ttgtagggtt ttaacgggca
    17581 cgattttcat atccgtcttg attgttttag ccgcttctag ggctgtttgg tagttgtttt
    17641 tcgcgtccgg atgcgccttt tgttcttctt cgctaacagg gttatcagga gcaaagaaaa
    17701 tagcagcacc tgccctagcc gaagctacaa ccttcttatc aatacctcca atgtctccca
    17761 cattaccatc gcggtcaatg gtacctgtac cggcaacaat acgaccatta cgaagatctg
    17821 ggtgagctat ttgagtatag atagctagac taaacatgag accagcactt gggccgccaa
    17881 taccagctgt tgaaaagcta attgggacat tgctgattac ctctgtacga tcaatcaagc
    17941 cgattccaat cccatttttt ccattttcca aggtgataat ctttccttct gcagacttgg
    18001 tttgcccatc ctcttcatag gtgaccttga cggagtcccc taatttttga gaactgacgt
    18061 aatcaatcaa gtctttggaa ctatcaaagg tctgatcatt gactgctgtg actgtatcag
    18121 agatattgag aatcccttta aaggttgaat tatccgtcac attcaaaaca taaactccaa
    18181 agtacttgag ttcgatatcc ttaccagctg tttttagtcc ttgatacttg gccatatttt
    18241 gcgatgtttg catgtagaat tgattgattc gcataaattc aacatcggaa gaaccacctg
    18301 tagtctcctg agcactacga atatctgtaa aaggtgtcaa ccaagcataa atcatatgag
    18361 ctaaagtagc atgttgaaca ccaaccgtaa cgaattgata ggcaccagct tccttatctt
    18421 ctgtgtcatt tactttaagg acttggcgaa tatcttccga accacctgga acctctatat
    18481 agtagggcaa aggcaccaca aatgccaaga aggtcacaat caaggccgca atgacataca
    18541 agggccatct aatctttttt ttcatttctt atttcctcca aaatactctc gggaacatgg
    18601 caggcaatat cctgaccaaa cttcaaaagc tctcgaacac ctgatgaact gatatagaga
    18661 tgttcaggcc ggctatgtaa ataaatagtc tctatatcag aagacagctg atgattgtag
    18721 taatcaaaac tagcttcata ttgcaaatcc gccgcattcc tcaacccccg tactaggaaa
    18781 gtagccccca gtctttttgc aacatcgacc accaatttat catgagaagc cacgacttca
    18841 acattttcca aatgtcccaa agccttttct agcccccgtt tacgattttc aagagggaga
    18901 aatccttgtt tgtggggatt aaaaaaaata cccacataaa gcttatcaaa aagtctgctc
    18961 gcccgttcaa tgatatccag atgcccattt gtcatcggat caaatgagcc tgtgaataag
    19021 ccaatcttat ctgacataga ctgtcacctt actaattcca taaatctttt ccttccagat
    19081 acccagacag gcaatttctt ctggaagttc aacggcttta tccgtctcgc acacaaccat
    19141 aacatcttca gaaaaaagct ctctctcagc cattttttca atatctgcta cgatttgttc
    19201 cttggcatag ggagggtcta agaaaacgag gtcaaattcc ccagatacct gttccaatgc
    19261 cctttctgca tccattttga ggagttgaaa ttttccaact tccttggtca tctggatatt
    19321 ttcagccacg atggtctgag ccttacggtc tcgctccacc aaaacagcac tggacatgcc
    19381 acgcgatact gcttcgatag ataaaccacc actacctgca taaaggtcca agactcgtcc
    19441 cccttcaaag tagggaccaa tcatgttaaa aatggctccc ctaaccttat ccgaagtagg
    19501 tcttgttgtc ttgccttcta gtgtcttaag gggacgtccc ccatagattc ctgatatgat
    19561 tttcatactg tttattatac caaattatag acaaaaagag aaagaaaacc gaaccttgcg
    19621 gttcgattct ctacaaaata ttttcgtaag tatcgcggac ttcttgaggc caaacacttg
    19681 tttgcacttc tccgatgtgt ctcttgcgaa gtaggaacat ggccatacga gattgtccaa
    19741 ttcctccacc gattgtcaat gggaataggc cattcaacaa agacttgtgc cattccaatt
    19801 ccaagcggtc ttcatcacct gtaatttcca cctgacgtct aagagtttct tcatctacac
    19861 gaattcccat agaagacaac tcaaaggctc cacctaaaga ctcattccag acaagaatat
    19921 caccatttag acccttgtag ccattctcag actcgcttgt ccagtcatca tagtctggtg
    19981 cacgtccatc gtgcggttta ccatctggca actcgccacc gataccaatc aaaaagacgg
    20041 ctccaaattc tttacaaatc gcattttcac gttctttcgg tgtcaagtct gggtagcgtt
    20101 ctaccaattc ttctgtatgg ataaaggtga tttgttttgg caagatagac tcgatgtcat
    20161 agcgggcttc aacagctagc tcagtcaggc gaatagcctt ataaatcttc tcaactgttt
    20221 cttttagata aacgatgtta cgcttaccat ttgggataac cttctcccag tcccactggt
    20281 caacataaac agagtgggtt gcatccaagg aatcctcatc tggacgaagg gctttcatgt
    20341 ggacaaagag accctctcct tcaccaaagc caaaacgagc caaggtgtgg cgtttccatt
    20401 tagcaagtga gtgcaccact tcataagtag catcagggat ttggagaacc ttgaccgata
    20461 ctggattttc cacaccagac aggttgtcct gcattccgtc accgacctta ctcaagatag
    20521 gaccttgaac ttcgacaact tctagcttat ctttcaaata ctgggtaaaa gtgtttttga
    20581 caaaggaaat ttcttcttgt tgatggataa aacttttctt catagacaac tcctcaaaaa
    20641 tttaataaac gtattataca cctatttcca agaaaagaaa agagaaaatt taaaaaaaaa
    20701 tcagtgtcac tcaaaacact gatttcatag accttttagt cattgcgacc aaagatacgt
    20761 agaatactta ggaaaagatt gataaaatca agatagatgc tgagagccat tgacaccacc
    20821 cagcctgtcg ctacacgacc ttgtgattgt tcataggcga ggcgaatctt ttggttatcc
    20881 caagcaatca accctgaaaa aaccaaaacc atggctacgc taatcatata atcaaagaag
    20941 ccactagcca agaaaatatt gactaccata gcaatcagta aaccaatgag agctgccatc
    21001 attgctcgac caatcccact caagtctttc ttggtaaaga taccaactgc cgccatgaca
    21061 aagaagagaa gggcgctcga tacaaaggca gataaaactg tacccggagt atagaaagcc
    21121 accacaaaac taagggtaaa gccgtttaaa acggagtaaa gtaaaaatac tggaagagca
    21181 gctggactat ttcttgaagc catactactg gcaacgaaaa ccaaagccaa ctccgcaaaa
    21241 gtagcaatgg tcaaccagag acgcccctgc atcaacaagt aaaccaactg agactgaaag
    21301 accgtcaaca taaggcctga taccaaagca gatagtccga ttcccagacc aacaaaggca
    21361 taaaccttag cgtaaaattg attgagacct gcacggtcat gtataatagt gtgattcatc
    21421 cttttctcct tttctgtgaa catctttcct tgattataac aaaaaaagtt aaaattagct
    21481 taaatggaag attaaaatac cggctgcaac tgcaacattc aaactctcgg cctgcccctt
    21541 catgctaata tggaccaact ggtctgcact ttcagccata aggggactaa ttccttgacc
    21601 ctcatttccc ataactagta caaaattttc tatagaaggc agttctctgt aatcaacaga
    21661 atctttagat agggttgttg ctagcactgg gatagctacc tttttagttt cgtcaagaag
    21721 cgcttgacta gtcatccggt aaatgggcag atggaaatga ctaccttgca tggaacgtag
    21781 ggttttgaga ctgtagatgt ctgccgactt atctgaaaca atcactcctg taaaacctgc
    21841 tgcatccgca gttcgaatga tagttcctac attaccagga tcttgcacat cttccaaaaa
    21901 caagaacttg ccctgactca aatcagcttg tcctacttct tctttttgaa ccaccgccac
    21961 aattccctgt ggagtctgag aatccgccaa atctagcaaa atatcctctg aaatccagac
    22021 agtttgcgga aaagcagcta actgatctcg ataattttct agggcaaaga ttttctcaat
    22081 cgtcactcca gcttggacag cctcttcaaa caagtgccag ccttcaatca aataggcaga
    22141 cttgcggtat tttttttggt gtaatttctt ggcatttttt accacagaat tggcttttga
    22201 ggttataata gtcatagaaa tattataaca caatcaaagg ggtttggtat gcaaaaggtt
    22261 agaatgattg cccaaggtag ggtacaggga gtcggctttc gttggggtgt ttacagcttg
    22321 gcacttgaaa ttggtggcat cacaggtcga gtatggaata acgacgatgg cacagtggaa
    22381 atcttagccc aagcagactc atctgctatc atggcaaaat ttatccaaga aatccgaaaa
    22441 ggaccgacac ctttttcaaa agtaagctac ttagatgtca aactaagcaa ctttcctccc
    22501 tactctgact ttaaaatcgc aaattaggtc tccagaacta ttgtatattt tgtaaaaaaa
    22561 cagtagaata gaaaggtata atttttaaag aaggaataaa aacagtgaaa tctattaaac
    22621 gttttgcatt ctcggctatg ggagtggcta tgttgcttgt cttgactggc tgtgtcaatg
    22681 tcgataaaac cacaggtcag ccaacaggat ttatttggaa taccatcgga gcgcctatgg
    22741 ctgaagccat caagtacttc gctactgata aaggtctagg ctttggtgtc gctatcatta
    22801 tcgtaaccat tatcgtacgc ttgattatct taccacttgg tatctaccaa tcatggaagg
    22861 caacgcttca ctctgaaaag atgaacgccc tcaagcacgt ccttgagcca caccaaacgc
    22921 gtctcaaaga agcgactact caagaagaaa aactcgaagc ccaacaagct ctctttgctg
    22981 ctcaaaaaga gcacggtatc agcatgtttg gcggtgtagg atgtttccct ctcctccttc
    23041 aaatgccttt cttctctgct atctactttg ctgcccaaca tactgaaggg gttgctcaag
    23101 caagctacct aggcattcct ctaggttctc caagtatgat tttggttgcc tgtgctggtg
    23161 tcctttacta tcttcaatcg ctcctttcac ttcacggagt agaagatgaa atgcaaagag
    23221 aacaaatcaa gaaaatgatt tacatgagcc cactcatgat cgtcgtcttc tccctcttct
    23281 caccagctag tgtcacactt tactgggttg tcggtggttt catgatgatt ctccaacagt
    23341 ttatcgtcaa ctatatcgtt cgtccaaaac ttcgcaaaaa agtccgtgaa gaactggcaa
    23401 agaacccacc aaaagcaagt gctttctcaa caccaagtgg acgaaaagac gttacccctg
    23461 aacaaccaac tgctattaca agcaagaaaa aacacaaaaa tcgcaacgct ggaaaacaac
    23521 gttcgagata agaagaaaaa ggcttagctg atttgctaag tctttttgca agtcaaaagc
    23581 ccgatgtttc catcaggctt cttttctatc catgtacacg tttcatataa tcttgataac
    23641 tttcggtatc catgagttgt ttagcgttct tgacgcgatc tgctgttggt ggtttgactc
    23701 cttcgaggga atatggaatt ccaagttcac gccacttgaa ctcacccatg gtgtgataag
    23761 gtagaatttc aaacttatca acatttttga gggtcttgac gaacttacca agttcaatca
    23821 agtcatcatc tctgtctgtc aatcctggaa ctagcacgtg gcgaatccag acaggttttc
    23881 caatatctga tagatactgg gcacaagcca agatattttt attggtttgg ctagtgacaa
    23941 tcttgtgctg ttcttcgttg atttccttga tatccaaaag aaccaagtca gtgacagcca
    24001 tgagtttgtc aaacttctca aggtaacgtg gtttattacg gaaaggaaga gcacaagtgt
    24061 ccaaggtaca gtggattcct tgttccttag ccttggtgaa gagggcaatc aggaaatcaa
    24121 tctgcaagag agcttctcct ccactgactg taatcccacc cttatttccc cagaaaccac
    24181 ggtagcgcaa ggcctctgtc aagacatcat ctaccgtccg ttcacgtgac ttattggact
    24241 ccatagccca agtgtctggg ttgtggcaat actggcaacg catgtgacag ccctgcaaaa
    24301 agacaataaa gcgaataccg ggcccatcta ctgacccaaa gctttctgtc gaatgcacca
    24361 ttcctgtcac ttgtccataa tcaattgttt cttcagacat atcgttacct tccttgaaaa
    24421 cgttttatag ttttattata tcacgacttg aaggaaaaac aagatttttg cctatttttt
    24481 agaaagcaat ctgtttttca atttcatttt caatctatta tcagattatt cttcaaaatc
    24541 gaagccatat aaggttgcaa aatagtcctc agggcgctct gcacggcgga tttgacgggc
    24601 tttaccttct tcggtataga ggatttccgc agaacgtaat ttggcattat actggtagcc
    24661 cattgaaaat ccgtgggcac ctgtatcatg aattaccagc aaatcaccga tttctgtatg
    24721 aggcagttcg cgattgactg caaatttatc attgttttca cagagtgaac caaccacatc
    24781 taccgcttca gctggtccat ctggatgggt cacgttgcta atatgatggt aagctccgta
    24841 catagctgga cgcatgaggt tgactgctga ggcatctaca cctagatagg tacggtaggt
    24901 ttccttctta tgagtgactc ttgtgactag agcaccgtga ggtgccagca taaaacgacc
    24961 caattcggtg aaaatcttga cctgaccaag acctgctgac gtaagaactt cttcatacac
    25021 cttacgaact ccctcaccaa tcaaggcgat atcgttcggc tcctggtctg gacgataatt
    25081 aacaccaata ccgccagaaa gattgataaa gtctaacgaa atgcccaact tttccttgat
    25141 ttcaacagcc agttcaaaga gctgacgagc caactctgga taatagagat gggtcacggt
    25201 attggacgct aggaaggagt gaagcccaaa agtcttggct cctttttcct tcaagatagc
    25261 aaaggcttca aagagctggt ccttggtcat gccaaactta gcctccccag gattgtccat
    25321 aatgtctgtc cccagttcaa aaacgcctcc aggattataa cgacaagaga tgatttctgg
    25381 aatgcctgct actctctcca gatgttcaat atcttcaaag gcatccaagt taatggtcgc
    25441 acccaattca cgtgcatagg cgtattcctt gtctggcgtg ttgttggaag agaacataat
    25501 ctcagaaccc agaaagtcca gtttatggct catcaaaagc tctacataac tagagcagtc
    25561 cacaccacaa ccttcttctt ggagaatttt caaaatagct ggagttggag tagccttaac
    25621 tgcaaaatat tccttaaagc ccttgttcca cgaaaaagct tggttgacag ctcttgcctt
    25681 ctcacgaatc cccttctcat catacaagtg aaagggagtc gggaactcgg caacaatcgc
    25741 ttctaactct tctctattga taaatggtgt tttcataagc ttccttctat tctgtttgca
    25801 aagaaaggct gggacaatcg ttccaacctt tagttctatc tcttatttat cttcgtcaaa
    25861 gatattgcca acctcaacat cgatggcttg gttcttgaca tcaatattag ttaccttcaa
    25921 gagtgacttg tagtcaaact gcttttcacg ttcttcttgg gcattgtccg caaagaccgc
    25981 tacacctgcc agttctgagt cgaactcgcg caagagacta atcataccgt tgaccgttcc
    26041 gccacctttc aagaagtcat ccacaatcaa gacacggctg cctgccttaa gactacgttt
    26101 tgaaaggaac attttctcga tacggtcacc acttgaacct gaaacatagt tgacgctaac
    26161 agttgaacct tcggtaattt tcaggtcacg gcgcacaatg acaaaagaga cattgaggac
    26221 attggcaact gcatttgcaa gtggcacacc cttagttgct acggtcataa ccgcgtcaat
    26281 tttttggtcc ataaagcttt tggcaataat acgaccaata tttttcaaga tggctggtgt
    26341 gctaagcaaa tcagacagat agatataacc acctggcaag atacggtcac tttctgacaa
    26401 cttggtacgc aagtcttcaa ccatttcctt agcatcctga ctcgaaatag acggtgtgaa
    26461 gatgacacct ccgccagccc cagtcactgt ctggatatga ccgatttcaa tttcctcaaa
    26521 ggcgcgtttg ataatgacga tatcttctga gatggatgat ttagcagact catacttttc
    26581 agcaaaagta ttgagactag ttagtttata aggattatta atcaaatagt tggaaatgac
    26641 aaccatccga tcacttcttc ttaatttcat ttctatttcc tattccattt ttattcaaaa
    26701 aatcaaaaag caaactagaa agctggtcgc tggtggttca aaacactgtt ttgagattgt
    26761 caatagaact gacaaaccct gtaatatacc tgcatatata catacgacaa agcgatacta
    26821 ccctagtttg aagagatttt cgaagagtat tcatttttgt cttttactta ttataccata
    26881 ttcacataaa aaaacgaaca ttcttatcct aaaaaatgct catttttctt aaattatcaa
    26941 tctaaatctg gtttatagaa ggaacgatta tccatagcga agattttatt ggacatctct
    27001 cctttatcca ccaaagccag agctgttgac atcatcatca tgcttgcatc cagattgtca
    27061 atcatatgga taatctctgc ctccataata cgtggacgga ctggacttcc atattcaagc
    27121 aagccgtggt gactgaggat gacatgacga agcaaaacga cttcttcctt ggtatcatcg
    27181 atgccgagtt ccataactgt cttggtaatt tcgctatcaa tgagagcgat atgtccaaga
    27241 agattacctc gcactgtgta ctctgtctgg tctggccccg tcaactcgat aaccttagct
    27301 aagtcatgca gcataatccc cgcatagagt aagctcttat tgagctgagg ataaacttcg
    27361 ctaatagcgt ctgccaaacg taccatggtc gccgtatgat aagccaagcc cgtttcaaag
    27421 gcatggtggt tggtcttggc agctggatag gagtagaatt ccttatcata cttggtgtag
    27481 agatttcgga caatccgttg ccagacagga ttttcaattt tgaaaatcat ttgcgacatg
    27541 tagtcacgaa tttccttgac atcaactggt gacttgacct tgaaatcggc tgggtcattg
    27601 ggttcaccag cttgaggcag gcggagagta atttgattga cttgaggggt attgttataa
    27661 acttctcggc gtcctttcat gtggacaacc ttacctgcgg taaaggcctc aatgttatga
    27721 ggttgggcat cccagagctt cccatcaatc tcgccactat catcttggaa ggtaaaggct
    27781 aggtagtttt tcccagctcg agtttgcctc aggtcagctg atttgattag gtaaaagcct
    27841 tcaaatagct catctttttt catgtgacta atcttcatat tcttcctcat tttcttgaaa
    27901 atggagtaga tcaagcgcag gctcgccttc tgacaactca atgtgacgga gcgtccgctc
    27961 gatagctatg gtacgacggt ttaataattc atcaatattg ccagaggcat gttggagatg
    28021 tttttgtgcc ttgaccagaa taccaccaaa cttgccaaac tcggtcttga cactggcaag
    28081 agtcttgctg atatggtcgg cactcttttg gatattaagg gtcttgaaac caactgatag
    28141 ggagttaaga agggctgata gggtacttgg tcctgcaacg ataatctgtt cttcccgtct
    28201 caaatcatca aagaagaccg gattgcggac gatttctgag tagagacctt ctgtcggaac
    28261 aaacaaaact ccaaaattgg tcgtccgagg tggtgctatg tacttgttcc taatatccct
    28321 agcaaaacgc ttgacacttg ctaggagtga cttacgacag cgttcgattt catccttgtc
    28381 acctacttca taggcttctt ctaagcggta ataatctgcc agtggaaact tagagtcaat
    28441 tggtaggtag acgtattctt ggtcgccttg tccgggtaac ttgatggcat actccactcg
    28501 ttcactagag ttttcaaccg ttgcgtattc tcgttcgtac tgggcaggtg tcatgatgtc
    28561 ttcaataatt tgccccagtt gcaattctcc cagaatccct cgcgtcttgg ttccagagag
    28621 aaccttgtta agagctccga catcacgggc aactgtctgc atttctccaa gaccacgatt
    28681 gacagactcc agttgtttag aaactgtctc aaaggaagcc tgtaagcgtg tctgcaaggt
    28741 cttttctagt ttttcctcga ccgtctggcg catttgttcc aaacgttgct catttgattc
    28801 ctgcaaggct tggagacgtt ggtctgtctt gtctctagtt tggaggagat tatctgtcat
    28861 ttcttgacgg acttgggtca ggccttggtg caattcaatc cgcacttctt gcaaacggtc
    28921 gctgacagcc acttccaaat ctttttggtc taactggctg gcttgtctgg cttggtcaaa
    28981 gcggtaatcc aactggtctg acaaatgatc tgcctgatcc tccaagctct tacttaagtg
    29041 tttctcctgc ctatcctgtc tttgccaaat cagaaagaga ccagctaggt tggcaattaa
    29101 taatagaata agtaaacttt ccatcctacc tcctgtcctt gctatgcagt acgaccacat
    29161 aaccatctgg gcaagtcacc gacacttccc tatctatata ttcgttagaa gcgtacactt
    29221 ttttaaagaa aaaattctcc tctgtcaact catacttagc tccaagaata gtcagctggc
    29281 tatcccgaac tggcataaag gctagatagt cgtagtctga acgaggttct agctgactgg
    29341 tcccttctga acaataggca atcaaatttt gcccatcctc aatttctatt tgacgcatat
    29401 agggtgccaa cttaggattg ctaggtagaa agacattggc caacatatgg tcaatacggc
    29461 cacccaaggc accgaaaata gtgacctcag cctgaggatt ttgttcaaag atggttaaga
    29521 gagccaattc cagatctgta tcatcctttt ctggtcgggc ttggacaaaa tgctgggcac
    29581 gtttttgaat cacctgtcgc tcttcttccg tcacagaatc aaaatctccg actgctagag
    29641 caagaggtaa gtcttcttcc aagacccaga gcgagcctcg atccacccca acaaaagcat
    29701 caaaatctgt ccgataatga ccgcggtttc cgcctgcaaa aacggcaacc ctagtccagt
    29761 tgttttctga gagtttgtac tcgctcattg acttctccct taaagacata ggaacctgct
    29821 acaaaaacag tcgcaccagc ttctttggct tgagcaatag tttggtcatc aatcccacca
    29881 tccacttcga tttcaaagtt caaacctttt tcctcacgaa gagcaaccaa ctcacgaacc
    29941 ttatccatgg tttctggcag aaaggcttgc ccaccaaaac ctggattaac cgtcatgact
    30001 aaaacttggt caactagatg aaggacgtgc ttgatggctt caactggtgt gccaggattg
    30061 ataacgactg aaggcttaac tccgagtaaa cgaatttttt ggagggcgcc atgaatatga
    30121 ggtgttgctt ctacatggat actgatgatg tctgcacctg cacgcgcaaa atcttccaga
    30181 tgatgctcag ggtttgacac catcaagtgg caatcgaaaa ccatcttact atgaggacga
    30241 aggctctcga ccacacctgc accaaaactg atttgcggta caaaatgact gtccatgata
    30301 tcgatatggg catattctgc cccagttgct tctagacgtt tgatttcacg ttcaaagttg
    30361 gcataatctg ctgccagaat tgacggagca atcttgtatt gagacatagg tttctcctta
    30421 ttttggaatt tttttgctga cttttttata ggtttctcta cgattttcaa tttcactaag
    30481 gaattgcagg taattatcaa aacggaaggt tgcaataaca ccctcttcaa cagctggttt
    30541 gacggcacaa gacggctcat gggtatgggt acaagtacgg aacttacaat ctcggctaac
    30601 agtagcaatc tctgggaaag cctgattgag gtcttcagcc cttgatactt catagtccag
    30661 agatgaaaag cctggtgtat ctgcgatttt acccccgttg agattgtaaa aactaacagc
    30721 tcgagtggta tggcgaccgc gacctagact gtctgaaatt tctcccgttt caagattgag
    30781 gtctggtacg agtttattga gaagagttga cttcccaaca cctgtctgcc ccataaagac
    30841 cgtaaccttg cctgttaaca aagacaggag ttcctcttta ctggtcacaa agtcatagcc
    30901 gatgtcacca taggtctgcc ggtaaaaatc cagttctccc ctatcttcca acaaatccat
    30961 tttggaaata tagacaatgg gatggatgcc cttgtgctcc aaaagaacca agaaacgatc
    31021 cagcaaattg ctgttaaaat caggttcctt gacggacatg attactacag cttgatcgat
    31081 attgacaata ggcggacgga ccagactgtt tttccgttcg tgaattttga ggatatagcc
    31141 ttctgaattt tcctcggcag agaaatctac ccagtcccca acataagggg tatggccttt
    31201 tttacggaaa ttcccacgcg cgcgtgtttg ataaacctgg ccatcactct ccacatagta
    31261 gaaacctgcc aaggctttaa tgatttgtcc ctgcatctta gagtccttgc cctttaagtg
    31321 cgtctgctag accggcaaat tctgccaagc tgagagcttc cccacgcaca cttggtgaca
    31381 agcctgcctg gtccaaagcc ttggtcagct tgtccttgac ctcttcagtc ttaccaaagt
    31441 aacctgtcaa gttattccac aaggtcttgc ggcgatgggt aaaactagcc ttggaaacct
    31501 taaagaaaaa gttctcatct tctactgcta cggctggctc tggacgacgc accattttca
    31561 agatggctga atccacattt ggcgctggca caaagaccgt acgaggcacg ataaaggcaa
    31621 ccttggctgt catgtaatac tgcacggcga tagacaagct accgtaagcc ttggtgttag
    31681 gctgggctga aatgcggtcc gctacttctt tctgcatcat gaccacaaac tcacaaaaag
    31741 gaatgccact ctcaatcaag tgcatgagaa taggcgtcgt gatgtagtaa ggcaaattag
    31801 ccactacctt gattggcagg ttaggatttt taaaattttg gatatgttgc gccaaatcaa
    31861 ccttgagaat atcttcgtta actacagtca cattatcaaa atcacgcagg gtatctacca
    31921 aaattggcac caaacggtgg tcaatctcaa aagccatgac ttgggctgca cgctcagcca
    31981 gaaactccgt caaggcacca atacctggcc cgatttcgat gacattgacc tggtcatcaa
    32041 tttcagccgt atccacaatt ttttgaagga tattggtatc cgtcaggaaa ttttgcccga
    32101 aggacttttt aaaggtaaaa ccgtgacgct ccagcactgc cttggtcacg ctataatctg
    32161 caattctcat ctattctctt ttctattatc tgttactact attgtaacac attccccttg
    32221 tattttggga atgaaaatca taccaaaaaa ctatctttcc tcatgaagaa agatagtctt
    32281 ggaaatcttt aaaagtggcc ttaacagttc tctcgaaaca tgcgttcaaa aaaatcagct
    32341 tcttgataac ttcgattttc aggtagggtc aaatccacat cctcctccac atcatccact
    32401 gtcagttcaa ccgtctgagg taaatttttc aaacgataat gcttttgcct ttgcccttca
    32461 atactagcaa aatcaagcaa atagccatgc actcggattt gaaccaaaag gagatgattg
    32521 gtcatatttt ccatgatgag gatatcttct aaaccacctc tggcactagg ataatcagat
    32581 accctgcgaa tacggatttt ttcacacatg agcaagtttc ctcatatcaa tgatttcatc
    32641 agccttattc cagactaggg gattatgggt cgcaatgatg ataattcgat tttcatcttt
    32701 caaatccacc aagagattca taacctcctc tgaattttca ggatcaagag ctgctgttgg
    32761 ttcatctgcc aaaatcaagg gtggattttt caaaatagtc ttagcaaggg caactcgttg
    32821 ggcctctccc ccagataaag tatagatttt ttgttctaaa tccaaatacc ctagattaac
    32881 tttttctaaa gcccccactt gcctttccaa acgttctact tttgagattt tctgaccaac
    32941 aaaacccaaa tccaaatttt ctttgattga ttggttttct aagaggccga aattttgaaa
    33001 gagatagccc atctggtctc gaaaatactc acgagtggga atggttttta aatctttccc
    33061 ctgatagaga acccttccac catctatctt ttctagcttt cccaagatat tcagcagcgt
    33121 cgtctttccg cttccactct ttccgattaa ggcataaacc ttgcccttct ccagcttgag
    33181 attcaaacca gagaaaatcg cgcggtcatt aaatttcttt tccaatcctt gaatatcaat
    33241 catcttattt tcctttcaat actgccatgc taccagcttc ttcttttttg tcctgcctta
    33301 ctaaaatcaa gagggcgtta agcgtaaaca aagctacaac tagagcgcta atcaaaccat
    33361 ctcttgtcaa aatactagat aggactaagc caagcaagag aactcctcct tgcgccagta
    33421 aatacttgcc atgaagctca tagattgtca taccagcaag acgtttaatc ataagctccc
    33481 gtctgaactg ctcaaaatag agaagattca tggaatcaaa taacaagata gccgtagaca
    33541 gggtcaaaat cgtcccaata aggagagagt aaaactccac ccgtttgtca tttagtacct
    33601 tggcaaaaaa tagctggctt tttaccaagt aagaaacctt gtgatacaga ccttgctctt
    33661 ttagagctgt gatgctgtct ccatatcgat ctagtttcaa ggcactatta gccgtagttc
    33721 cccacaacat ccctgcaaca ggtcttgttc cagtcgcttg cggcgttaga actacaataa
    33781 tcggatcttt taggtactgg cgtgttgtct tgtacccatc attatagagg aaacgttcct
    33841 gtcctgtttc tgtaaaagct agccttacct gtgggaggta gtgtttctga ctcgtcactt
    33901 ctacactttc agatgaaaaa ttttgcaggt aatctgtaaa caatccttgg tagtagacag
    33961 actgctctcg caagctctca ggcaagatca gcccaaactc tccctcagac aagttttgca
    34021 tcttgtccat aaactctgaa gaaacggtaa tcttttcttc tatcagatag cgtggtgaga
    34081 catagataac attccctgac ggtgtgtagt cactgagacg attgccatct aggtccactt
    34141 ctgctccatc tgagaaattg tcaacattgc tcataatata aaaagagtct gtattggcta
    34201 accgttcttc agtaaatgtc tgccactcac gattatcctt acgcgttcct tcttcatcgg
    34261 caaatgcact agaccaacca aaggatagac ggtaacggtc tgaggactgg ctccatttat
    34321 tgctagctct ctccatttcc tgcatttcac ggtagtgggg taggagagct gtcgcactcg
    34381 atccgaccac caatacagct aagagttgcc ccaccatcat caatgtcatc atacgtttga
    34441 gagggagttt ccctttcaat agatccacca gactattttc ctgtaaacca agtagatgga
    34501 cgacacttag taaggtagaa atccctgcca aggtcaatcc atagagtaga agagcaatga
    34561 tgaccagttg caccgttgcc ataaacaagg caccttgata ccagagaatc cccaatccca
    34621 aaagactgga taccagcact gagcagataa gctgtctcac atcttctaac actggtctga
    34681 gagcaactcc aaacaagctc tcaccagcta ttaagcgaat ccctgcttga cgaagggatt
    34741 ttatccgata aatcagggtc agactcataa aggtcagcag aaaaatagct aaactcagta
    34801 gcaccatagg ggtggccgtc aatagtaaga ctatcgaaaa tggatcttct ccattcgaaa
    34861 caaagccttg atagccaagt tctttcaagg tggtctgtaa gctcactcca tccaaacttc
    34921 ctgacacaat caagtaagac cctaataaat cactcgtttc tgcactctcc ttggaggaaa
    34981 tggtcagacc ttctggaagc tctccctcac cataagttgc ataggtaaag cgtgtttctc
    35041 cagcttcatt tggctcaacg attcgacggg cgatgagact attatgctct accgccaagt
    35101 gactcaaagc ctctgtcacc tcttcgcgac tagctactgg ttgatttgtc atcattcctg
    35161 tcacatcaac agaaggatag ttaccaaata aaatctcttc tcgatggtca acggaagtta
    35221 tcaccatata aagcgatacc aataccattg aaatcaaaat aaataaacgt ttcatcattt
    35281 cctccaaaaa gttacttggt cacttagtga gaaggtgacc aagtaaagct aaacaatagg
    35341 gctataccat tctaaacatt atagtagaat gcaactttct ctccccaaga agtacgaatc
    35401 catgcacgag aagtccctcc agcaccagca tatcccttgt cagatgaacc agtttttctg
    35461 ctaacaactg ttgaactatg gtattttgaa gggtgatagt agtttgagta agcaccaccg
    35521 ttacctgaac cataagtcca aacaccacct tctgggtatt gaacggctgc agaggcaact
    35581 gctacacttc cacctaatgt tgctgcaatg ctcgctacaa gagctaattt tttaactgtt
    35641 tgtttcatat tgatactcct ctatttttga ttacaagatt gttgagttac ttgctcctct
    35701 ttccattatc aacgttgata ctattatatt accaaatgat attctaaaat tatttgtttt
    35761 tctctaaatt gtcaaaatag caccctgaaa tgaactttta tagtcattat actccatctt
    35821 tatcacacta tcaaggacat caatgtcctt aaaatctaac tatttcatat tatttttagc
    35881 ctatatctaa aaaaacagtt ctaaagacga actttagaac tgttttgata cgaggacaag
    35941 gacatttttg tcactgattc actatgttta taaatatttt ttgacatcct cttgccattc
    36001 ctctgtcaat ttctttacta gaaattcatc tccaattagc tgcgcaaatg ttttagaaga
    36061 ctgataaaat gattcagcta aactaaaatc tctttcttct cttaatgctt gcttccacaa
    36121 aaacataaat acaagaggtt tcttttgata atcttgagtt ttatccataa tttcttgtaa
    36181 acacgataga taatcattaa aacaatcagt tactcctacc ttttcaagac aacacattcc
    36241 tgaaataaga gtatctctaa ttataaagaa gttttctaat ttagttacct ttttctgttc
    36301 caaaagaaag agcattagct tttcgatttg atttataaat ttggcaagat cttttctaat
    36361 gagcatttga taaaaaaaca aacgaatcaa caacatatca tttgttgaat aaacttcttt
    36421 ttctatgatc tgagacatat gttcctcaag tattaactct gcatattcag gccttctagt
    36481 tctagaagta tccaaacacg cctgcaatac ttcacatgct aattgttctt ctttaggaag
    36541 attatcaaag tatgttttat aaatctcttc caaacacgct tccttcttat cgtactcctc
    36601 ttctttacca tagattggtt cacgtaaaat ctggtatttc aattctaaat aagcaggagg
    36661 aagagctgaa aaatccggca taaggctata aactggaact cctagccggc gagcaatata
    36721 ggctaacttg ggcaaactcg gttgcgaagc tccactttca attcgcgaca gttgacgaac
    36781 tgtcagttct tgctcatctc cacaaaaatc tggacgacta actccttttt ctatccgaat
    36841 ctctttaatt ttttgaccaa ttaacatcag acgcctcctc ttctacctgc ttcgaaaaat
    36901 actgtgaaac ttaaaaaatt gtaacggtca catctttcct actcataaga tttcatagct
    36961 tcttccactt ctgccaaagt aaccccaaac aactctaggc gtttgaggag ttgcttgccg
    37021 ttagaatagc cgattcggag agtctctccg agatattccc tacgcttacg gctgtctgcc
    37081 cctactagaa aaccaaggcg aatcaagtcg ctacgactaa tgtcaaactg actctcatgt
    37141 tcaaattgtt ctgtcacctg agctagagcc gttttcaggt cttcatagct ggcatgctca
    37201 attcccagag aacgcccctt ggtcttggac ttgggaacag cttcatctcg cttgagaaag
    37261 gcatgctgaa ctgttggaat gaccgtcatg atcatgcgcc gaatccgttc cccattaaaa
    37321 tctgggtctg taaagacaat gactccatga cgttggtgca ggcgctgaat ccgctctata
    37381 tcctgatcat tgatggcaga acctcgagtc tcataggtct ccacatcgaa ataacgtttg
    37441 agattgaccg tatcatcacg cccttcaacc acaattactt gggaaatttt ctctttcatt
    37501 acttgctgtc cagtccaaaa attcgttctg catttgcagt cgttgctacc gccagctctt
    37561 ctgtcgtcat accacgcaag tcagcgataa agtcgaccac atagcgagta taggctgttt
    37621 tattttcacg accacgcttg ggtacaggtg ctaagtaagg cgcatctgtt tccaccaaca
    37681 tcttgtccaa aggtaactct ttagctgctt cttggaggtc agttgccttc ttaaaagtca
    37741 ccactcctga gaaggaaatg gtcataccaa gatccacaaa cttctctgcc cactcaagcg
    37801 tccctgaaaa tgaatgcatg ataccaccac gaggaccaac gccctcactc ttgataatct
    37861 cataggtatc ttccagcgca tcacgggtat ggacaacaaa aggcaaatcc aagtccttag
    37921 atagctgaat ctgacggcga aaaacctgct cctgcacctc tttgggcgct gtcatccaat
    37981 ggtaatctaa gccaatttca cctaaagcca caaccttggg atgttttaac ttatccaaca
    38041 agtaagcctc aacttcctct gtataagtac cagcttctgt aggatgccaa ccaatagtcg
    38101 catagagctg ctcatactca tctaccaact ccaaggcacg ctcaatcgtc ggtttatcaa
    38161 aaccaacaat attcatctgt gtcacaccca tctcagcagc caaggcaatt tcttctgcct
    38221 cacgacctgc aaattcttct acattcaagt gtgtatgtgt atcaaaaatc atctcttcta
    38281 acctcgtttt ctatcttcta ttataccaaa aaagaggagg ggcacctaat ttttcggttt
    38341 cccctcctct cttcaataga gagctattct gctatctttt ctatccgata ttgcccatct
    38401 cctattccac agttagagac agaagagatt ggctacattg atagactatt cctattcagc
    38461 taaagtatgt gattatcttg ggttctcact tttctcaccc atcactagga ttgatgactt
    38521 ctcaaaatcc cccttataat ctaactttaa gtagagaata gaattttcta gctgttccat
    38581 tttctacgtc tagtctttct tcctagcaaa gcaaaaccac tggttgccgc cactagacca
    38641 agactagcaa gtgctgcact tgatgctgaa cctgtgttag gtaattgttt gccagcaggt
    38701 gactggtagg taacatcttg cattgttcct gcagttgctt gcggtgcact tgttgtctta
    38761 ggagcagcat taggagccac tggtctctta agaactgtaa ccatggcaat ggcttgcact
    38821 ccaatcgttt ctgcttcctt cacatcttcc atagttttcg tattttcaat ctctttgaga
    38881 gctgcttgtt tttctgcttc cactcttgct aaaagttctg ctttttcttt atcagaaagc
    38941 ggtgcgcctt tgatttcatc ctgcttgtcc ttggctgctt tttcaatggc atttttagct
    39001 gattcttttt cagtagctaa ttgcttagaa gcttgtgatt gagctgagtt ttgtgaacct
    39061 gtgtgagctg gtccacctgc ctggctacca ccgcctgcat tcgcattagc atctgagctt
    39121 ccagtattgc ctcccttatc tacacctagt gtagtttctg gcttatactc tggtgtagct
    39181 tcttgagtta cagattcacc tttcgcagat tgttgaactg tatcttttcc tagaatcgtc
    39241 actactgaac catctgggaa tgtgattgtt gctgtaccat ctccagctac ttcaacttta
    39301 tagcaaaatg aaacaataac aggacaaatc gatcaggaca gtcaaatcga tttctaacaa
    39361 tgttttagaa acagaggtgt actattctag tttcaatcta ctataacatc gcttccgaat
    39421 ccatttgcat ctactgaact tttttacaaa aataaaaatc agtagactcg agttcctact
    39481 gatttttgat agaattcgtt tggattatgc agccaaaact ttgcgtcctt tacgacgacg
    39541 agctgccaat acgcgacgac catttttagt tgacatacgg ttacggaatc cgtgtttgcg
    39601 cgcacgacga agtttacttg gttgataagt acgtttcacg atgaatacct cctcatagat
    39661 tttgtattcg tttagccggc tataaagtga tcagttacta aacatacttt actattctat
    39721 ctgattcttt cacttttgtc aatagctcta ggcaaatgtt tccagctttt tcgaatgcaa
    39781 gccctatcta cgatactgtt tcaagaaacg agtcatcttt tcttggattt gggctaactc
    39841 atcaacacga ggaaggtaaa cgatacggaa gtggtctggt tcctgccagt taaagcctcg
    39901 accatgaacc aagagaacct tttcctgctt caagaaatca aggacaaact gctcatcatc
    39961 atcgatacgg tacatattgc ggtcgatttt tgggaagata tagagccccg ccttgggttt
    40021 aacggcagac aaacctggaa tatcttgaat ggcattatag atgaaatttc tttgctcgta
    40081 gattcgtcca ccaggaagaa gcaattcatc gactgattgg tgacccccca aggaagtttg
    40141 tacgacttgt tgggccaaaa cgttagagca aaggcgcata ttggacagca tattgagccc
    40201 ttcgatatag cccttaacat gagtcttagg gccagacaag accatccaac ccacacggaa
    40261 acctgctatg cggtgggatt ttgacagacc attcatgctg acacagaaga catctgatgc
    40321 caagctcgcc acaggcgtat gcacatgtcc gtccattacc atgcggtcat agatttcatc
    40381 cgcaaagata atcaaatcgt tttgacgggc aatctcaata atctccagca agagttcctt
    40441 aggataaagg gctccagttg ggttatttgg attgataagg acaattgcct tggtattgga
    40501 agtgattttt gacttgatat cgtcaatatc tgggtaccat tccacagctt catcacagat
    40561 atagtgaacg gcatttcctc cagctaggct gacagccgcc gtccatagag gatagtctgg
    40621 cattggcact aagacctcat ccccattgtc caaaagcccc tgcatggaca tgacaatcaa
    40681 ctcactgaca ccatttccaa ggtaaatatc atcaatatct acgtttggga atttcttcag
    40741 ctggcaatac tgcatgatgg ccttacgggc tgagaaaatc cctttggagt tagaatagcc
    40801 ttcactatca cgcgcattca taatcaagtc atgaatgacc tcgtctggcg ctgtaaagcc
    40861 aaattctgct ggatttcctg tattcagacg taaaatcttt tctccattcg ctcgcatccg
    40921 catggcttct tccaatacag gaccacggat atcataagca acatgctcta acttactaga
    40981 cttgttatat tctttcatct tgtttcctca attcatcagg atagtaacat tataccacta
    41041 gaaagagaat gcgacaagtt tactgaaatg tgttactagt ttcgtataga agaaaaacct
    41101 tgctaaaggc gaggttaaga acgtagagat agcaggtatt ttgcaaagac acatcacata
    41161 ccaaaagata aacctagaaa aagcaagcct agaaaggagt cataaagaag attaaacatg
    41221 aggaaaagcc ccatatcatc aagtaatccc aacgcccact tcgttttgca actagaaata
    41281 agattagatg gtagagtaca tgaaagacta aaaatccaat aaaacctgga taaagaagcg
    41341 gtaccagact ctctaattga cagatcatga tcacttctac caagactgaa actaggataa
    41401 ttccataata caggaaattt gatttttgaa aagagttttt catcattctc ccttccttca
    41461 cttctttcct gctatccttt cttttatttt atcatatatt tatatagagt ttaagcccta
    41521 atattctttt gaaaaatact ttttttgctt tacttctata gtgaaaaggt ttacaattat
    41581 agtaagaaaa tttcaggagg tttcattatg gcacaacgtt accaaaatat catggtcgca
    41641 atcgatggtt ctaaggaagc ggacttggct tttgtcaagg gagttcattc tgctctacga
    41701 aacgacgcta aactcaccat cgcacatgtc attgacacac gcgctctcca aagcgtatcc
    41761 acctttgatg ctgaagttta cgaagaactc caagtcgacg ctgaaagtct gatgaaagag
    41821 tacgaaaaac gtgctaaaga tgctggggta gcagatgttc atatcgtcat tgaaatggga
    41881 aatccaaaga ccctgctagc acgtactatt ccagatgccg aggaagtgga cctcatcctc
    41941 gttggcgcaa ctggtctcaa cgcctttgaa cgcctcttgg tcggctcttc atctgaatat
    42001 atactccgcc atgctaaggt cgatttgctg gttgtgagag aacaagaaaa aaccttataa
    42061 tcacaaagaa aaggagcccc tagctccttt ttgtttacga tttatttctc tctttatggc
    42121 gttcgtaagc cttgagctgg cgctgcagtt cctttttaat agcaggttct ggagcatatt
    42181 tttcttccca attatctggt tttaagattt tatgggtcac tggatcaaaa tgagccttgc
    42241 catctggaaa aattttcccc atattggcct gatggacaat atcaaaaata cgttctgggt
    42301 ccacccccat caagacaaaa ctgccgtagg tgaagtaaag cgtgtcaatc aaggcatcca
    42361 cttgccctat caaatcttgc tgagcaggtg tcttcttggc tactttatct gctgccttat
    42421 caagggtctg atgaagttgc gatacagctt gaccaaaatc ttcttcagaa ggactggctg
    42481 ctcgaacaaa ctccaccaat tcttctattt taaaaccagc cctatgggtt gcaccctcta
    42541 aatcccaagc tcgaggttct tcttgggttc gttcatccat catgtggtgg aaggtcttga
    42601 ccttattgaa atgatagtca cggctgacaa agactttttc tgaagacaaa acaccaaaat
    42661 gttccaaggc cttgtggatt ccatcttgtt gattgctagt ggtaatgtgc ttggcagctt
    42721 ccttgacact gctactacca tttcccatag cgaccgacat accgacgcca gccagcattt
    42781 caagatcatt atctgagtca ccaaaagcca tgacttggtt gaggtcaaag ccatattctt
    42841 tcccaactcg gcgaatgcct tctaatttag aatttccctg attgatgaca tccgatgcaa
    42901 aaggattgct acgtgtcaat ttcaagtctt caaaatcagc tgccgccttc tcagattctt
    42961 ctggtgtcat cagcatcaaa acttggtaga taggctgatt catcaggtga agcaggtcct
    43021 cttccttttg gggaacaacc ttgctgacca tgcgattaaa agactgactc accgtccgag
    43081 ttaaaacaga gggaacgaag cgactaattc gttgggaaaa agaacccaga ccaaaggaca
    43141 tgattttaga acccaacatg gcatccttgg tccctagagc aatctccgtg ccctcttttt
    43201 tagcatagct aattagatgg cgcaaatgta acttggaaat agggctcgtg aacaagactc
    43261 tgtctttact aaagatatac tggccattat aggttaccgc aaaatccaga tccaaatcgt
    43321 ccatcaattc cttaacaaaa aaaggtcctc gccctgtcgc tacgccaact agtacccctt
    43381 gttctttgac aatcttaatc gcgtccttag tggatttcaa aacactcttg cgattgttga
    43441 ccaaggttcc atcgatatca aaaaaaacag ctttgacttc catcctattc caatctcccc
    43501 ttttgtgata caatgattat accacatttc agaaagagtg agtaaatcat gcctaagaaa
    43561 atccttgttt tacatacggg tggaactatt tccatgcagg ccgatgcttc tggcgctgtt
    43621 gtgacgagtt cagataatcc catgaaccat gtgtccaacc cacttgaagg aatccaagtc
    43681 cacgccttgg acttttttaa ccttccaagt ccccatatca aacccaaaca tatgctggtc
    43741 ctctaccaga aaattaaaga ggaagcagat aactacgatg gagtggtgat cacacacgga
    43801 accgatactt tagaggaaac agcctatttc cttgatacca tggaagttcc ccatatgcct
    43861 atcgttctaa caggagccat gcgtagctcc aatgagctcg gtagtgatgg tgtttataat
    43921 tacctaagtg ctttacgagt ggccagcgat gacagggctg ctgacaaagg agttttggtc
    43981 gttatgaacg atgaaatcca cgctgccaag tatgtcacca aaacacatac gactaatgtc
    44041 aacaccttcc agactccaac acatggcccc ctcggtctca tcatgaaaca ggaaatcctc
    44101 tacttcaaaa cagctgaacc tcgtgttcgc tttgaccttg atcacataca aggtttagtc
    44161 cctatcatct cggcttatgc tggtatgaca gatgagctga ttgatatgct ggatttagaa
    44221 cacttggacg gtttgattat ccaagccttc ggagctggta atattcccaa agaaacggct
    44281 caaaaattag aaagccttct gcaaaaagga atcccagtcg ctctggtatc acgatgcttt
    44341 aacggtattg ccgagcctgt ttatgcctac caaggtgggg gcgtacagtt gcaaaaagca
    44401 ggcgttttct ttgttaaaga actcaacgcc caaaaagccc gcttgaaact cctcatcgcc
    44461 ctcaatgccg gactaacagg acaggctttg aaagactata tggaaggcta atactcttcg
    44521 aaaatctctg caaaccacgt cacgtcgcct taccgtatgt atggttactg acttcgtcag
    44581 ttctatctac aacctcaaaa acatgttttg agctgacttc gtcagttcta tctacaacct
    44641 caaaaacatg ttttgagctg acttcgtcag ttctatctgc aacctcaaag cagtgctttg
    44701 agctgacttc gtcagttcta tctacaacct caaaacagtg tgttgcgcag cctttaacca
    44761 gccgcctagt ccgctctatg gtattcatta agtcaacatc tcttgtttaa gagcacaaaa
    44821 tcaggaaatc ttctcgattc cctgattttt tctatttacg ttttcgtgtt gagctacgtt
    44881 ctgtcaaacc atgaggtaag agaacttcac gttcttccaa ctcttcctta tgcataatct
    44941 tggtcaacat acgcatacta atggcaccaa ggtcataaag aggttgggca atcgttgtca
    45001 agtttggacg ggtaaagcgt gagatttgtg aatcatcact agtaataatt tcaaaatctt
    45061 ctggcacaga aacaccctta tcagccaaac cgttcaagac tcctgctgcc aactcatcac
    45121 ctgtcacaac tgctgcagtt gcatttgatg aaatcaaacg ctctgctaag gcgtaaccat
    45181 catcatagct atatttagat tcaaatacca aaccctcact ataagcgatt cctgcttttt
    45241 tcaaggtttc cttgtagcca actaaacgaa ccttaccatt gatgtcatcc actagcggac
    45301 cgctaacgaa agcaatacgc tcattttctt tagcaaggta actcactgca tcaattgttg
    45361 cttgcttata gtcaatattg acacttggca actggtgctc aacatcgaca gttcctgcga
    45421 gaacaatcgg agtacgtgaa cgcgaaaatt ctgagcgaat tttatctgtc aagtgataac
    45481 ccatatagat aatgccatct acctgctttg aaaagagggt attgacaaca gaaacttctt
    45541 tctcgttatc ttcatcgcta ttagctagga caatattgta cttgtacatt tctgcaatat
    45601 catcaatccc cttagccaaa ctcgaaaaat aaccattggt aatatttgga atcacgacac
    45661 cgacagtggt tgtcttttta cttgcaagac cacgcgcaac tgcatttgga cgataatcca
    45721 agcgatcaat tacctctagc acttttttac gggtattctc ttttacattt ttattgccat
    45781 tgaccacacg gctgaccgtc gccatggaaa cacctgcttc acgagcgaca tcataaatgg
    45841 ttactgtatc atctgcattc attccttttc ctgtcctttc tatctcacac attcttttac
    45901 aagtagaggt actgattgaa gctctatatc tacttacaaa agtgaagatg tgaaaatttc
    45961 gttttcatat ttctacttat tccattctat cactaattgt aaacactttc aagtgttttt
    46021 tgaagattga ttgaaaaaat ttcatagaaa acctaggttt agctccttgc taccacctta
    46081 gactaaacaa aaaggaggaa actaagccct cctaaagtta tagtaaaatg aaataagaac
    46141 aggataaatc gatcaggaca gtcaaatcga tttctaacaa tgttttagaa gtagaggtgt
    46201 actattctag tttcaatcta ctataggtat tgttccattc actaccgtca attttagcac
    46261 atagtcttca tgaaaatatt atatcatcat aaccaaccag attcttttgc gatattagct
    46321 gcctctgttc gattaccagc atccaatttt gaaagaatat tggtgacata gtttcgaata
    46381 gttccgtttg agaggtaaag ctgatctgcg atttcttggt tggataagcc ccgggcgatc
    46441 ccctttaaga cagcaatctc ttgttctgtc aacggattgg gacgggtcat caccacttcc
    46501 atcaattcag gcgaatactc cttgcgtcct tcgaggacgg tgtgcaaggt ttgcatgagg
    46561 tctgcaacgc ttcgttcctt taatacataa gcatccactc cagccttgac cgcacgttca
    46621 aaatacccag cacgcttgaa ggtcgtcacc acaaccacct ttgtttcaag cctttctgat
    46681 cgtatccact ccaagacttc aagacctgtc ttaacaggca tttctacgtc aaggatggcg
    46741 atatctacag actccttttc taatagttgg attgcttctt gcccattctt ggcttgaagg
    46801 acagactcca catctggttg aagcgtgagt aattgacaca tggcatctcg caacatactt
    46861 tgatcttctg cgactaatac tttcatctta gtttctctcc ttataaggta gtcgaacttg
    46921 cacttccgtt ggatgtttct gactgattac acttacttct cctgaaaatg gaaaaacacg
    46981 atctcggatt gtatggagct catctccttt tagaaaagca aagccgcagc catcatcact
    47041 tactgttaaa atgagttcct tctctgtccg ttctaatttt aagtaagctt tagacgcttt
    47101 ggcatgtttg atgatattgg tcaccaactc aagcaaaatc atagaagcca ttgactccaa
    47161 ttcttgagta aggctagcag tatctagttg gttatctgtt tccacctcaa ttccagcaat
    47221 ttctaacatc tttttcacag tctctagttc ggatgtcaaa gttctagact taagattttc
    47281 cacaatggtt cgaacttcac gcattgattc tttgctaatt tgctgtattt ctcttaattc
    47341 cttttccact tgtggataag cctgcatttg aaatagctgc aaggctagat ctatcttgac
    47401 actaagcata gcaaaggtat gtcccagact atcatgcaaa tcctgaccga tacgattgcg
    47461 ctcattttct gctagcaata gatttatctg ggtattttgc ttgacctgag cttctttcaa
    47521 atcctcgaca aggcgaattc gaaccgagcc caaagtcatc aaatcgacaa aagtaagaat
    47581 tacaagcata tagactagaa actcaacttc gattctctga aaaatcaaaa gtcgccccac
    47641 aacaaggact tgagcaagga gaaatgtcca tacatgtaaa gactttaaac tacgtacgcc
    47701 aaaatgataa attaagatat tggaaaggaa aaagaaaaac cagatataat tcccagcaac
    47761 aaaggcggta ttcccagcta catagaccag catgatcccc cagaaaagcc aagataggcg
    47821 ctggttctta gttattaaaa cacccaaata cgtcactaca aatagaatat caaccaataa
    47881 atgccaagca ggaagctccc caatcactac aggtaggatg ggaaaaagca taaaaatcaa
    47941 actggtccaa aacatatagt gtatgctttt cagtctttca agcattaagc attctcctta
    48001 tgaccttgaa ggtaaatagt caaaccaaat aaaactgctg aaaaaacaag taaataaact
    48061 gtggctgata gattgatgcc accctcgttt aagaaggtct tgagcaactc catcaattga
    48121 taggtcggga gacacttacc aactgcttgc atccagtctg gaaataaaga aatgggcatc
    48181 cagagtccgc ctaaaacagc caatcctaga taaagaagat tgcccacaac agacatcagc
    48241 tgactagttg gtaagagagt caaggtcaag ccaagtgcta caaaagcaat actccccaca
    48301 atcagcaaaa tcgcagctcc aacccatttt actagaggca tgtctacacc tcttacaaaa
    48361 tgtccaactg taaaaacaac cagaattgag accaaataat caaccagcat acttgttatc
    48421 tttgatagat aatattctac catatttaca gggctatgac gcaatgtttt ctgccagttg
    48481 ttcatcttat cggtatgtaa aacagctgga aatgagaaga tagttgtcga catcatggaa
    48541 aaggcagtca tggagatgag gtaatcacgc ataaaattcg cgggttcacc tggtgtgtcc
    48601 tgatagatac cagaaaaaaa taaatagaaa gccgtcggca tccctaccga caatagataa
    48661 tagattaatt gtcgtttggt caataaaaat tctatcttac taagtgctat ccatcgtttc
    48721 atcttagtta tctcccttct gcgtctcttc aaagattgta ttcaacaaac tacgattatt
    48781 aacttcgatt tcttgcatcc tacatcctgc ttgggctaat agttcccaga aagcatctgc
    48841 ttctcgagtg actacttgta aagaatcttg ctttagggtc cagttttcaa ccaaatttga
    48901 ctgctctacg acttccttgt aagctatagg aaggataaag tgcttttcta tttcctcgct
    48961 acgcatagct agaggcgtcg tatctcgaat caactctccc ttatttaaga gcaaaatgcg
    49021 gtctgcagtg tgttccactt cctcaatata atgggacgaa tagagaatgg tgactccttg
    49081 cgcttttaac tcctggacaa tttcccaaaa acgttgacga gttgaggtat ccatggacgc
    49141 agtaggctca tctaaaaaaa caatctttgg tcgcccaatt aaggtcaaga cgaaagaaaa
    49201 gagacgcttt tgaccgcctg ataatttttc tgccaactgt tctttttgtt gcttgacaaa
    49261 ctgcaatagt tgatcaattt cctgattgct caaaggattt ggatagatac gttgaaagaa
    49321 agcaatcaac tctttaactt ttaatttctg aacgattaca ttttcttgag ggaggtaagc
    49381 cctagtatag tctaacttag aactcgtcac tggtaaacct tgaatagata cttgaccgct
    49441 tgtgaccagt ttatctccaa gcaaacaatc taagagtgtt gtctttccgg caccatttgg
    49501 accaattaag gcaacacatt caccatcgtt gatttcaaag gagatattcc gcaaaatttc
    49561 cttgtctttt attttcttac tcaatttctc aactttaacc accgtcatga gactctcctt
    49621 tcaaccactc cattcccata aggaaaacga cgaaaatcat aaatccaaac cccaaagcac
    49681 cacgaatgaa ttggcgaagc aaggcttgat caaaccaatc agtaaacatt tccactaacc
    49741 ataccaagag tgacaggccg ataaagaaat agatgatccc tctcttcatt cctcaaactc
    49801 ctttttcaca tctctgacta atttcaaacc ttctctaaca agccaagaca tgattccaaa
    49861 gccagcaaag accttccaag gaaaatggta gaaatcctca tccaatcccg aaaacatgag
    49921 ataggtcata actcctgcta ctactaaact tactgcgata atcattttat ttctcatctc
    49981 ttcttccccc atttcatact acaattatag tcttttaaaa tcagaggaga cagaagcttc
    50041 tgtcactaaa aaatatgaca aatgtcataa aaaattctgt tcaaaacaag caagatacac
    50101 tatacaataa aacacaatca gaaaaatcta aggcaacttc ctcaaaagag atatcaaacc
    50161 caattcacac cataatgtaa actaatactt atttaaaatc aaaaagagta aaaattttta
    50221 tcagacaaac acatatatag tgtattgaat ctataacagt aggccttaaa tactaaaata
    50281 tttctataaa ttaatttaac tttcctgata gaactgttca tatcttattt caattctcta
    50341 tattatacgt tgaaccaaac ccttctattg ctttcttaaa aatttataag agttataaaa
    50401 tctgttaaat ttcaatgtgt atatctaaac tacggtattt attgaaaaga ctggagacaa
    50461 aaagtatacg ctgccaaaat gaattactga aaatcaaaaa agagagaacc aaactgattc
    50521 cctcttaatg tatataatat ctagttttaa aaatacacac tcacatatct ctgt
//
LOCUS       DBERMM010000011        48298 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.011, whole genome shotgun sequence.
ACCESSION   DBERMM010000011 DBERMM010000000
VERSION     DBERMM010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 48298)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 48298)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..48298
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.011"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..334)
                     /locus_tag="ACL8AS_000841"
     CDS             complement(<1..334)
                     /locus_tag="ACL8AS_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000490588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228730.1"
                     /translation="MFSEIIKKYDIVTLKDSGFLRGDWFIGSALMAHDYESLKEGIYF
                     YPQETIWTRILDLEYINPYWEIYNQTYNFLLVNKQDSLAMNFLTSLLREIEVISSKTL
                     DFVVITSNE"
     gene            complement(338..793)
                     /locus_tag="ACL8AS_000842"
     CDS             complement(338..793)
                     /locus_tag="ACL8AS_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228731.1"
                     /translation="MIVLYDSFDSIVNCFDKLKGQYILLSVAFESSIKNYSWKDFNFE
                     YHKRIEIVDSFHSFTKGMVLIENCNYKINRAIIQPATEILMLNYLKKKSMDLRIDFTH
                     SKVMANKKFLEEGYRFSIVSQETIINNDDIIICETFSPEMIWCLYRVKG"
     gene            complement(866..1588)
                     /locus_tag="ACL8AS_000843"
     CDS             complement(866..1588)
                     /locus_tag="ACL8AS_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HGS1228732.1"
                     /translation="MITYRNDLLSKELDILISFFKKCEVGKISLVITGSLARGNPRIK
                     DGKLESDIDILVIVDSIQQLISIKKTLEGRFHFVHKISLIFCLKERINRSRYRGIINS
                     IRSVDNLLVDNLHIKNQIIEALDSPTNIVEQTRSMIQEFCYYSSKYLISKNNYLELKL
                     EKYWKEIATLNHIDKKIKHLDFERIFAVLKEHKIQILDSSEYFFQNVKTSENIYLEMR
                     DLVSLENQGLDFEHCILSLGER"
     gene            complement(1575..2444)
                     /locus_tag="ACL8AS_000844"
     CDS             complement(1575..2444)
                     /locus_tag="ACL8AS_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="HGS1228733.1"
                     /translation="MKHKKVLIIGYGIMTRGILKILKQSKKYNIYLYSRHLNSTINGI
                     IFIREDELPDAINQVDFIITCFSNHIETDNFINEFLLNIQSLRKTIVIDFTTSRIDCV
                     EKFKKTVEIKGGYYIEAPFTGGKLGSNSGQLSIFLHIDEGVNYNKKELMELLKLISKK
                     IYFFEKSTEPTKFKLIYNSWGAYLLYSIKLFNPLQYGFSPKSLEVANTIVCNDGWMSL
                     VCNSKLEQINDQDFDDIHFRVEYMVKNLEYANFSVFHDEVKEINYLLQQYRDCLVTDS
                     GKDYTVIGKYDNL"
     gene            complement(2548..2619)
                     /locus_tag="ACL8AS_000845"
     CDS             complement(2548..2619)
                     /locus_tag="ACL8AS_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_128650800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SHP2/SHP3 family peptide pheromone"
                     /protein_id="HGS1228734.1"
                     /translation="MKKISKFFPILMLVMDIIIIVGG"
     gene            2701..3552
                     /locus_tag="ACL8AS_000846"
     CDS             2701..3552
                     /locus_tag="ACL8AS_000846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016182753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rgg/GadR/MutR family transcriptional regulator"
                     /protein_id="HGS1228735.1"
                     /translation="MKSKLGITLRKVRKGKQISLCSVADEHLSKSQISRFERGESEIS
                     CIRLINILDKLHITLDEFLILHDEDYTKTESFANLIQYIRKQYSLQNINNIQSLLSDS
                     SNYTLDSFEKTMVKSILHTMDSRIIPSDDELLQLADYLFKVEKWGYYEIILLGNCVRT
                     INYNSYFLLTKEMLNNYIYSSLNKTNKRIVTQLAINCFILSIDKEEFSNCSYLINEIK
                     GLLENELNFYEQTVFLYATGYYEFKRQLSSGIETMKQAIQVLDILGEDKLKLHYTSHF
                     DKLVNNK"
     gene            complement(3593..4929)
                     /locus_tag="ACL8AS_000847"
                     /pseudo
     CDS             complement(3593..4929)
                     /locus_tag="ACL8AS_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261806.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1250 family conjugative relaxase"
     gene            complement(4923..6005)
                     /locus_tag="ACL8AS_000848"
                     /pseudo
     CDS             complement(4923..6005)
                     /locus_tag="ACL8AS_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511339.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha amylase N-terminal ig-like
                     domain-containing protein"
     gene            complement(6168..7052)
                     /locus_tag="ACL8AS_000849"
     CDS             complement(6168..7052)
                     /locus_tag="ACL8AS_000849"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family protein"
                     /protein_id="HGS1228736.1"
                     /translation="MKKAMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKAL
                     DATHFAEEASREQYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKLLE
                     INQDIDGAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEIEDKTKFGILT
                     YAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNYFADKKIFEENKDGYANIL
                     ILKDASIFSKLSVIPDLLKGDVVANDNIEYIKARNIKISSDSELESDVDGDKSDNLPV
                     EIKVLAQRVEVFSKPKED"
     gene            complement(7164..8018)
                     /locus_tag="ACL8AS_000850"
     CDS             complement(7164..8018)
                     /locus_tag="ACL8AS_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="HGS1228737.1"
                     /translation="MLGAIIGDIVGSVYEWNNIKTKDFPLFRKDCFFTDDTVMTCAVA
                     EAIMNGGQKDDFIDAMKKYGRMYPNADYGARFNAWLNSDNREPYNSFGNGSAMRISPC
                     AWIMDCGFYAKTGIWPSSRGLTSLSAEVTHNHPEGVKGAMATADAIFLCRFYFGGYCR
                     EYEQSINDNPTECKRRIKDYIEKEYDYNLSQTLDEIRPNYRFNETCQETVPQAIIAFL
                     ESRDFEDAIRNAISLGGDSDTLAAITCSIAEAAYGIPDWIKDKAYSYLDEPLKDVVRR
                     WENRIKAY"
     gene            complement(8076..8834)
                     /locus_tag="ACL8AS_000851"
     CDS             complement(8076..8834)
                     /locus_tag="ACL8AS_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HGS1228738.1"
                     /translation="MVVYIRQSKLPSEVSINKYNAQVGAYLQGEEVILYQSFSEIKEL
                     TSEDIVVDYIMETRALLKMMGLNVPVHDYPIELKEFYGRKIYAGILGEIVNIPDNWGK
                     FIKPKAGSKVFTGRVVNGTHDLIGIGLPFDYPIWISEVVEFIAEWRCFVLDGRVLDVR
                     PYTGDYHAQFDASVIDEAISCWKDAPIAYGLDIGVTRDGRTLVVEVNDGYALGNYGLS
                     PLKSINFHRARWKEMVKPYFEKNEIFKIQQDVIF"
     gene            complement(8896..9084)
                     /locus_tag="ACL8AS_000852"
     CDS             complement(8896..9084)
                     /locus_tag="ACL8AS_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HGS1228739.1"
                     /translation="MATDKNRIMISLDDKNLEKLENLVEDARDRRGMRLTKSQVIELL
                     LNTVDYFDDIMGAIYSKK"
     gene            complement(9406..9972)
                     /locus_tag="ACL8AS_000853"
     CDS             complement(9406..9972)
                     /locus_tag="ACL8AS_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228740.1"
                     /translation="MVILELYQNDYSKDLVAFDSIEDGKAFVAQIPGYTLETEDGFEV
                     EYFNPKNIPDYMEIIFNGNIVPLSRFMFDPGENVNIIWKEISNLSLKNDRVIEGYSKI
                     DAYVVNNHEVKAYVETRETNYRKAKDFLESRGYEIDRSFFGSEDGEAILYRKKGIEVW
                     HFLCHLDPMFVEIEDVEGYVKEEVGEIQ"
     gene            complement(10240..11919)
                     /locus_tag="ACL8AS_000854"
     CDS             complement(10240..11919)
                     /locus_tag="ACL8AS_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000150 - DNA strand exchange activity
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HGS1228741.1"
                     /translation="MSKEKIKVYLYTRVSTSIQIEGYSLEAQKSRMKAFAIYNDYEIV
                     GEYEDAGKSGKSIEGRIQFNRMMEDIKSGKDGVSFVLVFKLSRFARNAADVLSTLQIM
                     QDYGVNLICVEDGIDSSKDAGKLMISVLSAVAEIERENIRIQTMEGRIQKAREGKWNG
                     GFAPYGYKLEDGKLFINEEEAVAIRTIFDQYVNTTIGANGISKYLENHGIRKIPRQNG
                     KNPLFDAGLIRKILKNPVYNGKIAFGRRTLEKVHGTRNEYKQVEQDEYLISEGIHEAI
                     VSDEVWQAAQVKLKSQAKKYEHVNKGKDTRTHLLSGIVKCPICGVGMFGNKCIKKKKD
                     GTKYKDFYYYGYKHRQMIRGHKCTFSKQIREEFLDDAVAEVIVKIVSNPKFASMMQEK
                     INMKVDTSEIEKEIDNYQKELRKSHSTKFKLIEEIDNLDVEDKHYKRRKQDLDDRLYR
                     MYDKIDELESSLIDAKAKKQTIEAEKLTGDNIYKVLIYFDKLYKVMNDVERRQLISAL
                     ISEIQVYEEKQSNGQWLKSITFKLPIIEENLNIGLDNDEQVECVSLLEKRS"
     gene            complement(12011..12172)
                     /locus_tag="ACL8AS_000855"
     CDS             complement(12011..12172)
                     /locus_tag="ACL8AS_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228742.1"
                     /translation="MDNDWNGLADLIANLIAKYAGALDLDNLPDPTPAKNQEMKNSFD
                     MAKTQIETD"
     gene            complement(12856..13584)
                     /locus_tag="ACL8AS_000856"
     CDS             complement(12856..13584)
                     /locus_tag="ACL8AS_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000224688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
                     /protein_id="HGS1228743.1"
                     /translation="MATNKRYYWIKLKEEFFTDKRIKRLRRISGGDTYTIIYLKLLLL
                     SLKDEGKLYYDGVESDFIKELALTIDETDDDVMVTVNYLINQGLLEVVTENDEYYLTE
                     IPNLIGSETAWAEKKRRYRQNKQRTLSLMSPTHVRQEIEIEKDIEIDKEREGEIDKKS
                     TPIFYGEFKNVRLSKEEYKNLKEKLNSHTDIMINKLSRYMESSGKTYQNHYVTILKWY
                     EEDKDKLRQKGLNKKMNYDVGESL"
     gene            complement(13711..14238)
                     /locus_tag="ACL8AS_000857"
     CDS             complement(13711..14238)
                     /locus_tag="ACL8AS_000857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008902124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PcfB family protein"
                     /protein_id="HGS1228744.1"
                     /translation="MINEEISKEAGQAAQTIISYTIKATKESINLEKEIRKKMNETLE
                     KANGNLKSLMGDEMKIKDLYKKGQLENISIDQIDLKDLKKELNKLGVSFSVMKNKESK
                     NYEIFFQAKDIKVMEYAFKQVIAKENKKEKESILKQIKKYKDLSKNKDKTKEKGKRKV
                     KEKVKPNKKDMTREI"
     gene            complement(14424..14597)
                     /locus_tag="ACL8AS_000858"
     CDS             complement(14424..14597)
                     /locus_tag="ACL8AS_000858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019118552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228745.1"
                     /translation="MNKRQELIDELIKANEDGTYKTYKSTEEIKAMNNEEIQIIYSNM
                     KNYLSDKRTHINY"
     gene            complement(14671..16311)
                     /gene="mobQ"
                     /locus_tag="ACL8AS_000859"
     CDS             complement(14671..16311)
                     /gene="mobQ"
                     /locus_tag="ACL8AS_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019213953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobQ family relaxase"
                     /protein_id="HGS1228746.1"
                     /translation="MADSFHFSVNIISRGKGKSAVASAAYISGEKIKNEWDGVTHDYT
                     RKEKILVKNIILPDHIPKEFNDRSTLWNKVEMAEKNSNAQLARQFIIGLPKELSLSEN
                     KNLVERYIKENLTSQGMIVDYAIHDESQDKNGNIHCHIMTIMRPINEKGEFLAKSKKE
                     YILDEKGEKVLNKNGKPKTRKVELTTWNDTGNVEKWRENFSDLCNKYLERAGAEKRVD
                     HRSFKRQNSDYLPTIHLGSAASAMERKGIETDKGNYNREIRKYNQLVKTIKEEIKTLK
                     GWIGNLLDNLSTAYEKFKDIERDKVIDNPKLFNLTNYLLTYSEIQKEKSKYLKGYAKT
                     NKEKYDFKKLTSAYSYLRKNNIETIGQLQTKIETLKSNSYRLNKKAKTIHKEMEDVEK
                     KILYYEIYKAKKEVYEEYQKKNIFTKEAFYNKHKKDIDRYKVVSGKLKKLLSDKEKLS
                     PKKWNEEKILLMSNLEEINKEKDKIKDEYQEINHIKYSVDFVNKELGIDLSIEIDKLI
                     KQGEKPSVIAQIKKFQDQVNKDNEYREMMKNKKMDQER"
     gene            complement(16621..16938)
                     /locus_tag="ACL8AS_000860"
     CDS             complement(16621..16938)
                     /locus_tag="ACL8AS_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000968321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3847 domain-containing protein"
                     /protein_id="HGS1228747.1"
                     /translation="MMASKRLSIEEQIEKKEESIKQLQNQKRQLKKKLNEQERKARNK
                     RLIEKGAVFESIFEESIDLTKDEFYKLIKTLNDEEIRLNIMEILEERIDDNVEKSSKD
                     EIT"
     gene            complement(16994..17473)
                     /locus_tag="ACL8AS_000861"
     CDS             complement(16994..17473)
                     /locus_tag="ACL8AS_000861"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: protein motif:HMM:NF013579.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1228748.1"
                     /translation="MFITEKKGKSSQVPTGSSIPKRYLLDGKTPRISATNIDNGILGY
                     YEDIDDKNYRVFENFISVSFLGAVFYHKYKASLDMKIHCLKLKNKELNKEVAFYLTSI
                     IRQALKNTEYKDQISSTVLPDIKIKLPIDSRGTPDWNYMERYIEDLKLKCNIANYNI"
     gene            complement(17472..17656)
                     /locus_tag="ACL8AS_000862"
                     /pseudo
     CDS             complement(17472..17656)
                     /locus_tag="ACL8AS_000862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612340.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(17807..18601)
                     /locus_tag="ACL8AS_000863"
     CDS             complement(17807..18601)
                     /locus_tag="ACL8AS_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000677523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228749.1"
                     /translation="MKGLWSNNLTCGYDEKIILENINIKIPEEKISVIIGSNGCGKST
                     LIKTLSRLIKPLEGEVLLDNKSINSYKEKDLAKHIAILPQSPIIPESITVADLVSRGR
                     FPYRKPFKSLGKDDLEIINRSMVKANVEDLANNLVEELSGGQRQRVWIALALAQDTSI
                     LLLDEPTTYLDISYQIELLDLLTDLNQKYKTTICMILHDINLTARYADYLFAIKEGKL
                     VAEGKPEDILNDKLVKDIFNLEAKIIRDPISNSPLMIPIGKHHVNS"
     gene            complement(18601..19608)
                     /locus_tag="ACL8AS_000864"
     CDS             complement(18601..19608)
                     /locus_tag="ACL8AS_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HGS1228750.1"
                     /translation="MQNLIIGIQKRKNRITLFSSLFLLIIISLSFFILLIGDESYSFS
                     TLIKVLNSETVPGASFSIMEIRLPKLLAGIIAGWSFGLAGFIFQTMLRNPLASPDIIG
                     VTSSSSIAAVFCILVLKTNSLTTGIISITCGLTSSLILFLLAKKDGFSAARLIILGIG
                     FQAVTRAGTSFLLLKVARYELQEVMRWLSGSLSFTKLDDIPLVLIVSIIATILVLFFN
                     KRLEIIELGEEIAIGLGANPELSRLVLIFCAVSLTAFSTSITGPIACISFLAGPIALN
                     IGKKRSPILAGLVGILLVLLSDIFSQNILPARYPVGVVTGLLGSPYLIYLLIKMNRRN
                     I"
     gene            complement(19608..20615)
                     /locus_tag="ACL8AS_000865"
     CDS             complement(19608..20615)
                     /locus_tag="ACL8AS_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FecCD family ABC transporter permease"
                     /protein_id="HGS1228751.1"
                     /translation="MRNKKQINLGIIFVICLGLLITIFLSLKLGTKEINIRDFLAAFG
                     MGNTNDDFIKSIIYKRIPRTIFAILAGSSLAISGVLMQSVTRNPIADPGILGINTGAS
                     LSVVIGLSFLGISSSISHISFAIIGGLVSAIFVYAIAVSGKAGLTPIKLALSGTCVSM
                     ALSSFVSFLILPNNNVLDKFRFWQIGSLGAATLSSISTLLPFIILGHLIAIFISSDLN
                     ALAMGDEMAVGLGVNVNRIRSLAIIASVLLCSSITAIGGPIGFVGLIVPHFCGLFISK
                     DIRTMTISSSFIGAELLLICDIIGRMLGKPGEIEVGIITAIIGGPVLIYVTMKNRGVN
                     N"
     gene            complement(20605..21630)
                     /locus_tag="ACL8AS_000866"
     CDS             complement(20605..21630)
                     /locus_tag="ACL8AS_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="HGS1228752.1"
                     /translation="MKNKFFLIAILAMCIVFSACSSNSVKNEENTSKEHALDKIVLDH
                     AFGQTILDKKPERVATIAWGNHDVALALGIVPVGLSKANYGVSADKGVLPWTEEKIKE
                     LNGKANLFDDLDGLNFEAISNSKPDVILAGYSGITKEDYDTLSKIAPVAAYKSKPWQT
                     LWRDMIKIDSKALGMEKEGDELIKNTEARISKELEKHPEIKGKIKGKKVLFTMINAAD
                     TSKFWIYTSKDPRANYLTDLGLVFPESLKEFESEDSFAKEISAEEANKINDADVIITY
                     GDDKTLEALQKDPLLGKINAIKNGAVAVIPDNTPLAASCTPTPLSINYTIEEYLNILG
                     NACKNAK"
     gene            complement(21751..22020)
                     /locus_tag="ACL8AS_000867"
     CDS             complement(21751..22020)
                     /locus_tag="ACL8AS_000867"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228753.1"
                     /translation="MTLRTEDQVKDYAREVLGFNEVEENINQGTGQITTFNQLGFKGY
                     SDKPDGWYLPKNMNDVAIILETKSEERDISKQIFIDELMKNIDII"
     gene            complement(22024..22242)
                     /locus_tag="ACL8AS_000868"
     CDS             complement(22024..22242)
                     /locus_tag="ACL8AS_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001207345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1228754.1"
                     /translation="MALNYKPLWIQLAKKGLKKTDVIAMAGLTTNVMAQMGKDKPITF
                     KNLERICKALSCTPNDIISFEDNFSDEE"
     gene            complement(22488..22766)
                     /locus_tag="ACL8AS_000869"
     CDS             complement(22488..22766)
                     /locus_tag="ACL8AS_000869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228755.1"
                     /translation="MKKDKEVYDNVCEYLSPHLNKDMEVLELACWFRVIIVIEANSYV
                     NIRSSRLLPKFKTQKINSWCAAYSIHFNNGYCKQHTNEFKDSLKSLIL"
     gene            complement(22980..24611)
                     /gene="rlmD"
                     /locus_tag="ACL8AS_000870"
     CDS             complement(22980..24611)
                     /gene="rlmD"
                     /locus_tag="ACL8AS_000870"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000914584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HGS1228756.1"
                     /translation="MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMR
                     VLKVNKKIGFGKVEKYLVQSPHRNQDLDLAYLRSGIADLGHLSYPEQLKFKTKQVKDS
                     LYKIAGIADVEVAETLGMEHPVKYRNKAQVPVRRVNGVLETGFFRKNSHNLMPLEDFF
                     IQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVRRGHYSGQIMVVLVTTRPK
                     VFRVDQLIEQVIKQFPEIVSVMQNINDQNTNAIFGKEWRTLYGQDYITDQMLGNDFQI
                     AGPAFYQVNTEMAEKLYQTAIDFAELKKDDVIIDAYSGIGTIGLSVAKHVKEVYGVEL
                     IPEAVENSKKNAQLNNISNAHYVCDTAENAMKNWLKDGIQPTVILVDPPRKGLTESFI
                     KASAQTGADRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVETVALLSK
                     LDVDKHISVEIELDEMDLTSAESKATYAQIKEYVWNKFELKVSTLYIAQIKKKCGIEL
                     REHYNKSKKDKQIIPQCTPEKEEAIMDALRHFKMI"
     gene            complement(24685..25659)
                     /locus_tag="ACL8AS_000871"
     CDS             complement(24685..25659)
                     /locus_tag="ACL8AS_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HGS1228757.1"
                     /translation="MRKKLFLTSAAILWAVTAMNSVHAATDVQKVIDETYVQPEYVLG
                     SSLSEDQKNQTLKKLGYNASTDTKELKTMTPDVYSKIMNVANDSSLQLYSSAKIQKLG
                     DKSPLEVKIETPENITKVTQDMYRNAAVTLGVEHAKITVAAPIPVTGESALAGIYYLL
                     EANGAKVPQANKDLAQEELKALSDINAENKDKSGYDANKLNVALADIKSGLAKAKESK
                     GNLTEEDIRKIVEDTLKNYKLDQVITGNQINIIINFALNLSKSDILSNADFTKTLNDL
                     KQSIVSQAGDSFKNINLNFDADKALEDGGNFLSSLWQALVNFFKSFGS"
     gene            complement(25733..26347)
                     /gene="pmp23"
                     /locus_tag="ACL8AS_000872"
     CDS             complement(25733..26347)
                     /gene="pmp23"
                     /locus_tag="ACL8AS_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000476388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase Pmp23"
                     /protein_id="HGS1228758.1"
                     /translation="MFKRIRRVLVLAVFLFAGYKAYRVHQDVKQVMTYQPMVREILSE
                     KDTPANEELVLAMIYTETKGKEGDVMQSSESASGSTNTINDNASSIRQGIQTLTGNLY
                     LAQKKGVDIWTAVQAYNFGPAYIDFIAQNGKENTLVLAKQYSRETVAPLLGNTTGKTY
                     SYIHPISIFHGAELYVNGGNYYYSRQVRLNLYIIKCFTLFSTSG"
     gene            complement(26347..27321)
                     /locus_tag="ACL8AS_000873"
     CDS             complement(26347..27321)
                     /locus_tag="ACL8AS_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HGS1228759.1"
                     /translation="MDIYIKKAIIHQFSPDDTELFLADKFLNITPKIEEYLRKKIEHV
                     YSDEAKTGIFEEENPFFNHITDDLLETSVTLANLWKEEFSISENLKTNDLIFVQFSKE
                     GVEHFAFLRIALRETLTHLGGEVDNPIKLTQNNLPGFGTGADEALVVNLQSSKYHLIE
                     KRIKYNGTFLNYFSDNLLAVAPKISPKKSIKELEKTAQRIAESFNTDDFQFQSKVKSA
                     IFNNLEESNELSPEKLANDLFDNNLTARLSFIDQVKEAVPEPVQFDEIDVSRQLKKFE
                     NQKLSLSNGIELIVPNNVYQDAESVEFIQNENGTYSILIKNIEDIQSK"
     gene            complement(27329..28585)
                     /gene="glyA"
                     /locus_tag="ACL8AS_000874"
     CDS             complement(27329..28585)
                     /gene="glyA"
                     /locus_tag="ACL8AS_000874"
                     /EC_number="2.1.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_function: GO:0070905 - serine binding [Evidence IEA];
                     GO_process: GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HGS1228760.1"
                     /translation="MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVM
                     AAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQAN
                     CAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPETELLDFDAIL
                     KQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPV
                     PYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFK
                     EVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQ
                     NLLDEVNITLNKNSIPYESLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKN
                     SENEAVLEEVRSAVKELTDAFLLYED"
     gene            complement(28647..29078)
                     /locus_tag="ACL8AS_000875"
     CDS             complement(28647..29078)
                     /locus_tag="ACL8AS_000875"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000942930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228761.1"
                     /translation="MLRDLQETDVKAICDINQEALGYTFSPEETASQLARLSQDSHHF
                     LLGYEDAANHVLLGYVHAEVYESLYSKAGFNILALAVSPQAQGEGIGKSLLQGLEQEA
                     KRCGYGFIRLNSANHRLGAHAFYEKVGYTCDKMQKRFIRIF"
     gene            complement(29080..29682)
                     /locus_tag="ACL8AS_000876"
     CDS             complement(29080..29682)
                     /locus_tag="ACL8AS_000876"
                     /EC_number="2.7.7.87"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003725 - double-stranded RNA binding
                     [Evidence IEA];
                     GO_function: GO:0061710 - L-threonylcarbamoyladenylate
                     synthase [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-threonylcarbamoyladenylate synthase"
                     /protein_id="HGS1228762.1"
                     /translation="MMDRIRQELEKGGAVILPTETVYGLFAKALDEKAVDHVYQLKRR
                     PRDKALNLNIASLEDILHFSKNQPAYLQKLVETFLPGPLTIILEANDRVPYWVNSDLA
                     TIGFRMPSHPITLDLIRETGPLIGPSANISGQASGVTFEQILKDFDQEVLGLEDDAFL
                     TGQDSTIVDLSGDKVKILRQGAIKREDILARLPEISFEEA"
     gene            complement(29666..30505)
                     /gene="prmC"
                     /locus_tag="ACL8AS_000877"
     CDS             complement(29666..30505)
                     /gene="prmC"
                     /locus_tag="ACL8AS_000877"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA];
                     GO_process: GO:0018364 - peptidyl-glutamine methylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HGS1228763.1"
                     /translation="MKLAQLFSNFEEELIRQGEEAESLSFVYSSLKNLSFTDFIFALQ
                     QEVTTEEEKQFVEDIYQQLAAHKPAQYIIGQADFYGMHLKVDERVLIPRPETEELVEL
                     ILTENLETNLSVLDIGTGSGAIALALAKNRPDWSVTAADVSQEALELASENASDQNFN
                     IFFKKSDCFAEISEKYDIIVSNPPYISREDESEVGLNVLHSEPHLALFADEDGLAIYC
                     RIAEDAKDYLKDGGKIYLEIGYKQGQSVPELFRKHLPEKRVRTLKDQFGQDRMVVVDD
                     GQD"
     gene            complement(30505..31584)
                     /gene="prfA"
                     /locus_tag="ACL8AS_000878"
     CDS             complement(30505..31584)
                     /gene="prfA"
                     /locus_tag="ACL8AS_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003747 - translation release factor
                     activity [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HGS1228764.1"
                     /translation="MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSKEEASNR
                     DTVIAYREYKQVLQNIVDAEEMIKESGGDADLEEMAKQELKDAKAEKEEYEEKLKILL
                     LPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAEAQGWRFEVMEASMNGVGG
                     FKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDI
                     DPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNREKAMKIIR
                     ARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTIL
                     SGKLDEVVDALVLYDQTQKLEELNK"
     gene            complement(31581..32171)
                     /locus_tag="ACL8AS_000879"
     CDS             complement(31581..32171)
                     /locus_tag="ACL8AS_000879"
                     /EC_number="2.7.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000068157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004797 - thymidine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thymidine kinase"
                     /protein_id="HGS1228765.1"
                     /translation="MAQLYYRYGTMNSGKTIEILKVAYNYEEQGKGVVIMTSALDTRD
                     GVGYVSSRIGMKRPALAIEETTDIFGYIRDLPEKPYCVLVDEAQFLKRHHVYDLARVV
                     DELDIPVMAFGLKNDFRNELFEGSKYLLLLADKIDEIKTICQYCKKKATMVLRTQDGL
                     PVYDGEQIQIGGNETYISVCRKHYFAPEINKENEEK"
     gene            32295..32477
                     /locus_tag="ACL8AS_000880"
     CDS             32295..32477
                     /locus_tag="ACL8AS_000880"
                     /EC_number="5.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005589823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="HGS1228766.1"
                     /translation="MPFVRIDLFEGRTLEQKKALAKEVTEAIVRNTGAPQSAVHVIIN
                     DMPEGTYFPQGEMRTK"
     gene            32615..33988
                     /gene="mnmE"
                     /locus_tag="ACL8AS_000881"
     CDS             32615..33988
                     /gene="mnmE"
                     /locus_tag="ACL8AS_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002906470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HGS1228767.1"
                     /translation="MITREFDTIAAISTPLGEGAIGIVRLSGTNSFAIAQKIFKGKDL
                     SQVASHTLNYGHIVDPLTGKVMDEVMIGAMKSPKTFTREDIIEINTHGGIAVTNEILQ
                     LAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNIAVKQLDGSLSD
                     LINNTRQEILNTLAQVEVNIDYPEYDDVEEATTAVVREKTMEFEQLLTNLLRTARRGK
                     ILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNINGVPLKLI
                     DTAGIRETDDIVEQIGVERSKKALKEADLVLLVLNASEPLTAQDRQLLEISQDTNRII
                     LLNKTDLPETIETSKLPEDVIRISVLKNQNIDKIEERINNLFFENAGLVEQDATYLSN
                     ARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLF
                     SQFCLGK"
     gene            complement(34035..34970)
                     /gene="dapA"
                     /locus_tag="ACL8AS_000882"
     CDS             complement(34035..34970)
                     /gene="dapA"
                     /locus_tag="ACL8AS_000882"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008840 - 4-hydroxy-tetrahydrodipicolinate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HGS1228768.1"
                     /translation="MSYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDG
                     ILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFG
                     GFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLAD
                     HPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGD
                     EMHEMFTAIAESDMKKAAAIQRKFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPL
                     VPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY"
     gene            complement(35026..36102)
                     /locus_tag="ACL8AS_000883"
     CDS             complement(35026..36102)
                     /locus_tag="ACL8AS_000883"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000542485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004073 - aspartate-semialdehyde
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HGS1228769.1"
                     /translation="MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKS
                     LKFKDQDITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQNP
                     DVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGA
                     GMGAILETQRELREVLNDGVKPRDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYT
                     YEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAF
                     PGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNS
                     VQIAETLHERGLVRPTAELKFELK"
     gene            complement(36444..36516)
                     /locus_tag="ACL8AS_000884"
     tRNA            complement(36444..36516)
                     /locus_tag="ACL8AS_000884"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(36481..36483),aa:Thr,seq:ggt)
     gene            complement(36616..37125)
                     /locus_tag="ACL8AS_000885"
     CDS             complement(36616..37125)
                     /locus_tag="ACL8AS_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HGS1228770.1"
                     /translation="MKKLTIRDVADIAIVAAIYVVLTVTPPLNAISYGAYQFRISEMM
                     NFMAFYNPKYIIGVTIGCMIANFFSFGLLDVFVGGGSTLVFLSLGVWLFAKYSKDYLF
                     NGLIRKDHFFFSILFSISMFTIAAELNIVAELPFFLTWFTTGIGEFASLIIGAIIIGK
                     IGRRIDLSK"
     regulatory      complement(37123..37219)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
     gene            37248..37679
                     /locus_tag="ACL8AS_000886"
     CDS             37248..37679
                     /locus_tag="ACL8AS_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HGS1228771.1"
                     /translation="MKKPIQKFFNNEILAYLFFGIVTTLVAILSRLVIYQLSHQELLA
                     TALANIIGILFAFITNDTIVFKQKKKNRLIRLVKFSLARLSTFLLDLFLTFLFVTQFP
                     HIIGQFVTENIDKINAIETIIAQIFIIIINYILSKVYIFRK"
     gene            37761..38138
                     /gene="mscL"
                     /locus_tag="ACL8AS_000887"
     CDS             37761..38138
                     /gene="mscL"
                     /locus_tag="ACL8AS_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="large conductance mechanosensitive channel
                     protein MscL"
                     /protein_id="HGS1228772.1"
                     /translation="MLKNLKSFLLRGNVIDLAVGVVIASAFGAIVTSLVNDIITPLIL
                     NPALKAAKVERIAQLSWHGVGYGNFLSAIINFIFVGTALFFIIKGIEKAQKLTGIKEE
                     KTDEKKPTELEVLQEIKALLEKK"
     gene            complement(38180..39274)
                     /gene="hemH"
                     /locus_tag="ACL8AS_000888"
     CDS             complement(38180..39274)
                     /gene="hemH"
                     /locus_tag="ACL8AS_000888"
                     /EC_number="4.98.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004325 - ferrochelatase activity
                     [Evidence IEA];
                     GO_process: GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ferrochelatase"
                     /protein_id="HGS1228773.1"
                     /translation="MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYD
                     NYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCI
                     CLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
                     SFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPW
                     IKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMP
                     NTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVK
                     KLIEKKGRENVKMPYLIKKMLEKAGKLPKE"
     gene            39429..40652
                     /gene="pepT"
                     /locus_tag="ACL8AS_000889"
     CDS             39429..40652
                     /gene="pepT"
                     /locus_tag="ACL8AS_000889"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0045148 - tripeptide aminopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HGS1228774.1"
                     /translation="MTYPNLLDRFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPE
                     MKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDG
                     GVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTSLLGADDKSGIAEIMTAIEYLTAH
                     PEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAEL
                     HFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEEV
                     RASYIIRDFEKDAFEARKASMQSIADKMNEELGSDRVTLNLTDQYYNMKEVIEKDMTP
                     ITIAKTVMEDLGITPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTM
                     ERAVDTIIGIVAYKG"
     gene            complement(40688..41341)
                     /locus_tag="ACL8AS_000890"
                     /pseudo
     CDS             complement(40688..41341)
                     /locus_tag="ACL8AS_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672614.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family hydrolase"
     gene            41339..41503
                     /locus_tag="ACL8AS_000891"
                     /pseudo
     CDS             41339..41503
                     /locus_tag="ACL8AS_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057566.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            complement(41774..42785)
                     /locus_tag="ACL8AS_000892"
                     /pseudo
     CDS             complement(41774..42785)
                     /locus_tag="ACL8AS_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669441.1,RefSeq:WP_007521835.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
     gene            complement(43011..46130)
                     /gene="phtE"
                     /locus_tag="ACL8AS_000893"
     CDS             complement(43011..46130)
                     /gene="phtE"
                     /locus_tag="ACL8AS_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtE"
                     /protein_id="HGS1228775.1"
                     /translation="MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDG
                     SQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDALFSE
                     ELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQKQEH
                     VKDNEKVNSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLS
                     ASELAAAKAHLAGKNMQPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELY
                     DSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPI
                     SGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAY
                     IVRHGDHFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRII
                     AEDESGFVMSHGDHNHYFFKKDLTEEQIKAAQKHLEEVKTSHNGLDSLSSHEQDYPSN
                     AKEMKDLDKKIEEKIAGIMKQYGVKRESIVVNKEKNAIIYPHGDHHHADPIDEHKPVG
                     IGHSHSNYELFKPEEGVAKKEGNKVYTGEELTNVVNLLKNSTFNNQNFTLANGQKRVS
                     FSFPPELEKKLGINMLVKLITPDGKVLEKVSGKVFGEGVGNIANFELDQPYLPGQTFK
                     YTIASKDYPEVSYDGTFTVPTSLAYKMASQTIFYPFHAGDTYLRVNPQFAVPKGTDAL
                     VRVFDEFHGNAYLENNYKVGEIKLPIPKLNQGTTRTAGNKIPVTFMANAYLDNQSTYI
                     VEVPILEKENQTDKPSILPQFKRNKAQENSKLDEKVEEPKTSEKVEKEKLSETGNSTS
                     NSTLEEVPTVDPVQEKVAKFAESYGMKLENVLFNMDGTIELYLPSGEVIKKNMADFTG
                     EAPQGNGENKPSENGKVSTGTVENQPTENKPADSLPEAPNEKPVKPENSTDNGMLNPE
                     GNVGSDPMLDPALEEAPAVDPVQEKLEKFTASYGLGLDSVIFNMDGTIELRLPSGEVI
                     KKNLSDLIA"
     gene            complement(46340..>48298)
                     /locus_tag="ACL8AS_000894"
     CDS             complement(46340..>48298)
                     /locus_tag="ACL8AS_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HGS1228776.1"
                     /translation="HYHYIPKNELSASELAAAEAFLSGRGNLSNSRTYRRQNSDNTSR
                     TNWVPSVSNPGTTNTNTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLVFD
                     PAQITSRTARGVAVPHGNHYHFIPYEQMSELEKRIARIIPLRYRSNHWVPDSRPEQPS
                     PQPTPEPSPSPQPAPNPQPAPSNPIDEKLVKEAVRKVGDGYVFEENGVSRYIPAKDLS
                     AETAAGIDSKLAKQESLSHKLGAKKTDLPSSDREFYNKAYDLLARIHQDLLDNKGRQV
                     DFEALDNLLERLKDVSSDKVKLVEDILAFLAPIRHPERLGKPNAQITYTDDEIQVAKL
                     AGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAAQAYAKEKGL
                     TPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNLQYTVEVKNGSLIIPHYDH
                     YHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERPHSDNGFGNASDHVQRNKN
                     GQADTNQTEKPQTEKPDEDKGHDEVSEPTHPESDEKENHAGLNPSADNLYKPSTDTEE
                     TEEEAEDTTDEAEIPQVEHSVINAKIADAEALLEKVTDPSIRQNAMETLTGLKSSLLL
                     GTKDNNTISAEVDSLLALLKESQPAPIQ"
BASE COUNT        13962 a         9445 c         7746 g        17145 t
ORIGIN      
        1 gttcgtttga agtaataaca acaaaatcta atgttttaga cgaaataact tctatttctc
       61 ttagaagact agttaaaaaa ttcattgcta atgaatcttg tttattaact aataagaaat
      121 tataagtttg attatatatt tcccaatacg gatttatata ttctaaatcc aagattcttg
      181 tccaaattgt ttcctgggga tagaaatata tcccttcctt aaggctttca tagtcatgag
      241 ccattaacgc tgaacctatg aaccaatcac ctctcaaaaa accactatct ttcagtgtaa
      301 caatatcata tttcttaata atttcagaaa acattttcta tcctttcact ctatataagc
      361 accaaatcat ttctggagag aaagtttcac aaataataat atcatcatta ttaattatcg
      421 tttcttgact tactattgaa aaacgataac cttcttccag aaatttttta tttgccataa
      481 ctttactatg ggtaaaatct atcctcagat ccatactttt tttctttaaa tagtttaaca
      541 tcaaaatctc agttgcaggt tggataatcg ccctattaat tttataatta caattctcga
      601 ttagaaccat tcccttagta aaagagtgaa aagaatccac aatttcaatc cgcttatgat
      661 attcaaagtt gaaatctttc caactataat ttttaatact actctcgaaa gctacagata
      721 ataatatata ttgccctttt aatttatcaa agcaattaac tatactatca aaactatcat
      781 acagtacaat cacatctact tttaatttta tacgatttat tgcataaaaa acaatctgtt
      841 gcagttggtc ctaatgtatt tattatcatc tttcccccaa gctcaaaata caatgttcaa
      901 agtctaatcc ttgattttcc aaagatacta aatccctcat ctctaaataa atattctcag
      961 aagtttttac attttggaaa aaatattcac ttgaatccaa aatttgtatt ttgtgttctt
     1021 ttaaaacagc aaatattctt tcaaaatcta ggtgttttat ctttttatcg atatgattta
     1081 atgttgcaat ctccttccaa tacttttcta gttttaattc caaataatta ttctttgaaa
     1141 ttaaatattt tgatgaataa taacaaaatt cctgaatcat agagcgagtc tgctccacaa
     1201 tattggtagg tgagtctaaa gcttctatta tttgattttt tatatgcaga ttatctacta
     1261 aaagattatc tacacttcta atactattaa taattccacg ataacgactt cgatttattc
     1321 tttccttcaa acaaaaaatc aaagaaattt tatgtacaaa gtgaaacctt ccctctaaag
     1381 tcttttttat actaattaat tgctgaatac tgtctactat aactagaata tcaatatccg
     1441 attctaattt cccatccttg attcttggat tacctcttgc caaggaacca gtaataacga
     1501 gtgaaatttt tcctacctcg cattttttaa aaaatgaaat tagtatatct aattctttag
     1561 acagcaagtc attcctataa gttatcatac tttcctatta ccgtataatc ttttccacta
     1621 tcagttacta agcaatccct atattgctgt aataaataat ttatttcttt cacttcatca
     1681 tgaaagactg aaaaattagc atattctaaa ttttttacca tatattctac tctaaagtgt
     1741 atgtcatcaa aatcttgatc attgatctgt tctaatttgg agttgcatac taaactcatc
     1801 caaccatcat tacatacgat tgtattcgct acctctagag actttggtga aaaaccatac
     1861 tgtaaagggt tgaatagctt aatagagtaa agcaaatacg ctccccacga gttataaatt
     1921 aacttgaatt ttgttggttc cgtactcttt tcaaaaaagt atattttttt tgaaattaat
     1981 tttaataatt ccattaactc ctttttatta tagtttacac cttcatcaat atgtaaaaaa
     2041 attgatagtt gaccactatt acttcctaac ttacctcctg tgaaaggagc ctctatatag
     2101 tatccccctt taatttcaac agttttttta aatttttcaa cgcaatcaat cctggaggtt
     2161 gtaaaatcaa ttactatggt tttacgaagt gattgtatat ttaataaaaa ctcattaatg
     2221 aaattatccg tttcaatatg attactaaaa caagtgatta taaaatcaac ctgatttata
     2281 gcatcaggta attcatcttc tctaataaat attattccat ttattgttga atttagatgc
     2341 ctactatata ggtatatatt atattttttc gactgtttca ggatttttaa tataccccga
     2401 gtcattatac cataccctat aattaatact tttttatgtt tcaaagtctc accactctct
     2461 aaaattttac gatttaactt aaatatgttt tagctagtaa gtatagtctt tagatactct
     2521 aaagacttag gtgtacacct aagtgattta accaccaaca ataatgataa tgtccatcac
     2581 tagcatcaaa attgggaaaa attttgaaat tttcttcata tttagacttc ctttcaattt
     2641 ttatttattg tacaataaat aaaactaagt taactttttg ttgggagaat gggaaaaact
     2701 atgaaatcaa aacttggcat cacacttaga aaagttcgta aaggcaaaca aatcagtcta
     2761 tgctctgttg ctgatgagca tctttcaaaa tcgcaaatat cccgatttga acgtggagag
     2821 tcagagatat catgtatccg actgatcaat attttagaca aattacacat tactttggat
     2881 gagtttctta ttttacacga tgaagactat acaaaaactg agtcatttgc caacttaata
     2941 cagtatatcc gtaaacaata ttcattacaa aacatcaata atatacaatc tctactttcg
     3001 gattcctcaa attacacttt agattctttt gaaaaaacaa tggtaaaatc cattttacac
     3061 acaatggatt caagaatcat tccatcagat gatgaattac ttcaactagc agattatctc
     3121 tttaaagttg aaaaatgggg ttattatgag attattttat taggtaactg tgtacgaaca
     3181 attaactaca actcctactt cttattaact aaagaaatgt taaataatta tatttactca
     3241 tctctaaata aaacaaataa gcggattgtc actcagctag ctataaattg tttcattctc
     3301 agcatagata aagaagaatt ttctaattgc tcttatttaa ttaatgagat aaagggattg
     3361 ttagagaatg aattaaactt ttatgaacag acagtttttc tctatgcaac cggttactat
     3421 gaatttaaac gtcaattaag tagtggtatt gaaacaatga aacaagctat acaagttctc
     3481 gatattttag gagaagacaa gttaaaatta cactatacta gccattttga taaacttgta
     3541 aacaataaat gaaatgattc tctatctttt aactaattag tcgtaaataa tattattcta
     3601 gtaaggcatt ctcgtgaaat tttagaactg taaatttatt ggtattaata attttcacaa
     3661 acaaatccaa tcttctagct atctcctcat atttattaat ttcattacca agttcctgtt
     3721 gtaattttaa aatatctgta ttgagtcgat ctaacattat tgattccgtc atgttcattt
     3781 ggtcaaaatc atacttagct aattttctag tctcatgatc ttcactcttc aaattgataa
     3841 ggacttccgc catcttgttt aaggtggcga ttttttcttg ggtttcttct agcttcatat
     3901 caatctctgc aatttctaat acatgctcat ctttgatttc ttggtattgt ttgttcgtgt
     3961 tagatagttc aatcataaga ttaatttcag aaatcttctc ttgaagactt tttaaagttg
     4021 gtcgtctata ggggagtttt tggctatcgt tgctcaattg tctgattaag gtcctaccct
     4081 tgatgaaaca attattatcc atgttttctt tattatagac aaagtaagaa gacgtttctc
     4141 gaatgtagac tttatatttt ttatgatttt cttcttccat aatatccaat tgatagttgg
     4201 gaatgaaaat aagaccgctc tgtttgacac cgaaagacac cttgatatag acgcccttat
     4261 caactagctt ctctatttgg ttctctgcaa gttccacttc aaattcacga acggtatctc
     4321 atttttcctt aaatgtctta aaggctttct caatctcttc agtggatact ttatccttat
     4381 ctcgttcttc ttggaaagca tggtactgtt cctgtaaatt ctctaatcct tctgaagcaa
     4441 cgacttcctt atttttaaaa taatcttgaa aaaatttgac atcatataat ttcttatcac
     4501 ttattttttg atgacccaaa cttatctttt gattattttc ttccaggata aaagttacat
     4561 tttttgtttt aagtcaatgg ttagattcaa ttcttttgct tttgttatta aatcttctaa
     4621 agaattgaca cggtttaaca aaaattctaa acgactttca atctcttgct tagcaaaatg
     4681 cgttctaaaa aattcttcat catatagatc tcgtttgctg agttggcgcc ctcgaattgg
     4741 ttttatcatc gttctatctg tcatcaaaaa acggctatgc ttttgactaa aatcaatctg
     4801 aacatgcaac tgctttgctt tctctaaaaa atcatcaaac gatttagatt gctgaagcaa
     4861 aaaataaaga cgttgtttca attcaaattt atgactagat tctttatatt ttttataatc
     4921 tcgaaaagat caggattttt agctaaaact gccttacgaa aatccttcca gaactgatgg
     4981 tcaatctcat tagccacatc caaacgccaa gcatcgatat taaactcttc aatccaataa
     5041 gtcgcaacct ttaaaagata attcttgacc tctggattgg ctgtatttag cttaggcata
     5101 tagtcctcga aaccaaaaac atgatagggt aagtctctct tattaactag cttttcagtt
     5161 gtcactggga attgttgaat atggaaccaa tccttataag cagactgttc accatttttg
     5221 acgacatttt tccattgaag agattgcgaa ccaatatgat taaataccgc atccagcatg
     5281 actttcatgc cacgatgatg cgcttgatcc accagttccc gaaaggtctc cttgtctcca
     5341 aaatgacggt caatttcaaa gtaatctgtc gtattgtact tgtgattgct tgtagattca
     5401 aagatgggac aaagatatag tccagtaata cccaagtctt gcaagtaatc catatgatca
     5461 ataatcccct gtaaatcacc accaaagaaa tcatcgctct taggtgtgac agatgaatcc
     5521 cagtctaaag tcccttctgg gtttaataga gcattgccat tggcaaatct ttcaggaaat
     5581 atctgatacc ataccgtatt tgaaacccag tcaggaacct tgcaggcatc aatctcatga
     5641 agataaggca acttaaatcc attcccaatt gcatgaagat tttctagaga attttccaca
     5701 caccctttat cgccatacaa aatattttga ccttctgtat ctctgagctc aaagagatac
     5761 tggatacgtg caaagtcaac tgacacttca acctgccaat ggtcaaataa ggtaccagaa
     5821 gttatcttga ccatttcttt tgtatcctga taaaactcct ccataaagat aaaagggtcc
     5881 ccatagtgca agttgatgct ttcaatgtcc cctttcttag ttcgaattcg aatatggagt
     5941 ttcttatcct tataaagata ggcatactcc gactcaggcc tatggtaaat agcactcaat
     6001 tccatcaatt tgtctcctaa agtattcatt caaattttac gcaaacgttt tcaaactcaa
     6061 taaatccagt atactatttt tgtaaactat ttgcaaggaa tgtccgttgt taaaggaact
     6121 atcttttaaa gtatacaaaa agccttaaaa aaggctttct ctatatacta atcctctttc
     6181 ggttttgaaa atacttctac tcgctgagct aggactttga tttctacagg taggttatct
     6241 gatttatctc cgtcaacatc tgactccaat tcactatctg aagagatttt aatattacgc
     6301 gctttgatat actcgatatt atcatttgcg acaacatccc cttttaataa atcaggaatg
     6361 acggataatt tggagaatat agaggcatct ttcagaatca aaatgttggc atagccgtcc
     6421 ttgttttctt caaagatttt cttatcagcg aagtaatttg tcaaaaggac caaaacatgg
     6481 ctagcttcac caacataatt tccattttct gtctcaacct taatgttaaa gacctgatct
     6541 gtcatgacag acttcatggt atttacagca taggttaaaa taccgaattt tgttttgtcc
     6601 tctatttcaa cattgtgaat cgcctcaggc agagaaccga tactaaagat ataaccaaaa
     6661 tagttgtcat ttgctttacc gatatcaatc ttattggtta aatcaaaatc cagttcgtca
     6721 attgcgccat cgatgtcttg attgatttcc aaaagttttg taatgaggtt acccgtaccg
     6781 cctgggataa tccctaactt aggaatgtag tctctctcat caatacctga aatgacttca
     6841 ttgacagttc catctccacc aaacacaacc actgcatcat actgctcacg agaagcttct
     6901 tcagcaaaat gtgttgcatc cagcgctttt tcggtaattt tggtttcaac atattcaaag
     6961 tattcttttg ctttattctc cagcttttct ttgtaatcca aagccttctc gccaccagaa
     7021 gtagggttga taattaccat tgcttttttc attgatttta tccttaattt taaacagaaa
     7081 tgtttacatt tcgtcgtatg caagtaaatg taatcctatt atacaatgaa aatacagaaa
     7141 agagaaatct gacgtactgg agattaatac gcttttattc tattttccca tcgcctaact
     7201 acatccttta agggttcatc caagtaagaa taggccttat ccttgatcca atcaggaata
     7261 ccgtaagctg cctctgctat gctacaagtg attgctgcga gagtatcact gtcgccacca
     7321 agtgagatgg catttcttat cgcatcttcg aagtctctac tttcaagaaa ggcgataatg
     7381 gcttgaggga cagtttcctg acatgtttcg ttaaaacgat agttaggacg gatttcatct
     7441 aaagtttgag atagattgta atcgtattct ttttctatat aatccttaat tcgtctttta
     7501 cactctgtag gattgtcgtt aattgattgc tcgtactctc tacaataacc accaaagtaa
     7561 aaacgacata gaaagatagc atcagctgta gccatagcgc ctttgacacc ttctggatga
     7621 ttatgagtta cctctgcaga aagactcgta agtcctctag atgatggcca tataccagtt
     7681 ttcgcataaa aaccacagtc catgatccaa gcacatggag aaatacgcat agctgatcca
     7741 ttcccaaagc tattataagg ctcacggtta tcgctgttta gccatgcatt aaaccgagca
     7801 ccgtaatcag cattcggata cattctgcca tatttcttca tcgcgtcaat gaagtcgtct
     7861 ttttgtccac cattcataat tgcttctgca acagcacagg tcataaccgt gtcatctgta
     7921 aaaaagcagt ccttccgaaa taaaggaaag tcctttgttt tgatattgtt ccattcgtaa
     7981 acagaaccga caatatctcc aataattgct ccaagcatca gattcctcct tgttcatttt
     8041 gatgcttttt atattggtta tctaccatat ttattttaga aaataacatc ctgttggatt
     8101 ttaaaaattt catttttttc aaaatagggt tttaccattt ctttccacct agctctatga
     8161 aaattgattg attttaaagg agataggcca taatttccca atgcataacc atcatttact
     8221 tcaacaacaa gtgttctgcc atcgcgagta acaccgatat ctagtccata agctattggc
     8281 gcatctttcc aacatgatat cgcttcatca attacacttg catcaaattg tgcatgataa
     8341 tcacctgtat agggtcgaac atctaatacg cgaccatcta acacaaaaca acgccattca
     8401 gctatgaatt ctacaacctc actaatccat ataggatagt cgaaaggtag accaatacct
     8461 attaaatcat gggttccatt aacaactctt ccagtaaaga cttttgaacc agctttaggc
     8521 ttaataaatt ttccccaatt atcaggtata ttcacaatct ctcctaaaat accagcataa
     8581 atctttcgac cataaaactc tttaagctca ataggatagt catgaaccgg aacgtttaag
     8641 cccatcattt ttagtaatgc tctagtctcc attatataat ctacaactat atcttcactt
     8701 gttaactctt ttatttcaga aaaagattga tataaaataa cttcttctcc ttgtaagtag
     8761 gcacctactt gagcattgta tttattaatt gaaacctcac ttggtaattt actttgtcta
     8821 atataaacaa ccatttcatc actcctatat cactagtgtt acaccaattt gtaaaaaata
     8881 atagcaattt tgctcttatt tttttgagta aatagccccc ataatatcat cgaaataatc
     8941 aacggtattt aggagtaatt caataacctg ggactttgtt agtcgcattc cccttctatc
     9001 tctagcatct tctactaaat tttcaagttt ctctagattt ttatcatcca agctaatcat
     9061 tattctattt ttatcggttg ccattttcat cacctcaagt taattctatc acaggtgtaa
     9121 cacttgtgtc aactggcttt tataatacat tagtttaaaa gtggagagga tttttaacac
     9181 agtaacttta aatctttggt attaaaaaat tttcacaata tttatagaaa taaaatctgt
     9241 ctcaaatcag ttatcaaatc tagtataaat tatgagcggc tactctaata ctttccctct
     9301 aaacaagaaa aagacttaca ctcaagggtt ttcttccccc ccttcgttat aacgttttga
     9361 ctcttttact agcaaaggta tatactcaca aggaactttg gttgactatt gaatctctcc
     9421 aacttcttct ttaacatatc cttctacatc ttcaatctct acaaacattg ggtctaagtg
     9481 acacaagaaa tgccaaactt cgatcccttt ttttctgtaa agaatcgctt caccgtcttc
     9541 acttccgaaa aagcttctgt cgatttcata tccgcggctt tctaagaagt cttttgcttt
     9601 acgatagttc gtttctcttg tttcgacata ggctttaact tcatggttgt taacgacata
     9661 tgcatcaatt tttgaatatc cttcgatcac tctatcattt ttgagggata aatttgaaat
     9721 ctctttccaa ataatgttta cattttcccc aggatcgaac ataaatctag ataaaggaac
     9781 aatatttccg ttaaaaataa tttccatata atccggtatg tttttaggat taaaatactc
     9841 cacttcaaaa ccatcttctg tttccagagt gtatcccggg atttgagcta caaaggcttt
     9901 cccatcttct atggaatcaa atgctactaa atctttagaa taatcatttt ggtacaattc
     9961 caatataacc atcgataatc tctccatttt cattatcagg ctaatgtaaa taagcacgtc
    10021 acctgaccaa ttcaggctct ctgtatcatc tcatcatatt tcctacttac tttacgagtc
    10081 ctatacccag aacacacctt atcgaccttc ggtctcacct cgtcgcattg gctgaacatc
    10141 tacttttact ttgctgatgc ttcaactcgt acaagcagtg ataccgcctc agcgtgatgc
    10201 gtcagtggga ctcaaaaggt tcggggaacc ttttgaggat taactacgtt tctctaataa
    10261 acttacacat tcaacttgtt catcattgtc caaacctatg ttgagatttt cttctataat
    10321 tggtagctta aaagtaatgg attttagcca ttgtccgtta gattgttttt cttcataaac
    10381 ttgaatttca gaaatcaaag ctgaaattaa ctgcctacgc tctacatcat tcatgacttt
    10441 atagagctta tcaaaataga tcagaacctt atatatgtta tctcctgtaa gcttttcagc
    10501 ttcaatagtc tgtttctttg ctttcgcatc aattagtgat gattctaatt catctatttt
    10561 gtcatacata cgatatagtc tatcatctaa atcctgtttc cttctcttat aatgcttatc
    10621 ttcaacatct aaattatcta tttcctcaat tagcttaaac tttgtagaat gactctttct
    10681 caattccttt tggtaattat ctatttcttt ttctatttca gaggtatcca ccttcatgtt
    10741 gattttttct tgcatcatag aagcaaattt cggattactt actatcttga caatcacctc
    10801 tgcaacagca tcatctaaaa attcttctct aatttgctta ctgaatgtac acttatgacc
    10861 tcttatcatc tgcctatgct tataaccata gtaataaaaa tctttatact ttgtgccatc
    10921 tttctttttc ttgatacact tgttcccaaa cattcccact ccacatatcg ggcattttac
    10981 aattccagaa agcaagtgtg tgcgtgtatc ttttccttta ttcacatgct catatttctt
    11041 tgcttgagat tttagcttaa cctgagcagc ttgccaaact tcatcggaaa ctatagcttc
    11101 atgtatccct tcagatatta gatattcatc ttgttcaacc tgcttatatt catttcttgt
    11161 accatgaact ttttctaaag ttcttcttcc aaatgctatt ttcccattat atacaggatt
    11221 ctttaatatc tttcttataa gacctgcatc aaacaaagga ttcttaccat tctgtcttgg
    11281 gatttttcta attccatgat tctctaagta tttagatatc ccattggctc ctatcgtagt
    11341 atttacatac tggtcgaaaa tcgttcttat tgcaactgcc tcttcctcat ttataaacag
    11401 cttgccgtct tcaagtttat atccatacgg agcaaagcca ccattccatt ttccttccct
    11461 tgctttttga atgcgacctt ccattgtttg aatacggatg ttttctcttt ctatttcagc
    11521 cacagctgat aaaacagaaa tcattagttt cccagcatct ttagatgaat caatgccatc
    11581 ttcaacgcag ataagattaa ctccataatc ctgcattatc tgaagtgtag aaagaacatc
    11641 agcggcattt cttgcaaatc ttgataactt aaacacaaga acaaaagata ctccatcttt
    11701 tccagatttt atatcttcca tcattcgatt gaactgtatt ctaccttcaa tagacttgcc
    11761 agacttcccg gcatcttcat attctccaac aatttcataa tcattgtaaa tagcaaaagc
    11821 tttcattcgt gatttttgtg cctctaacga atacccctct atctgtattg acgtagatac
    11881 tcgtgtatag aggtatactt ttattttttc ttttgacata gtattaacct caatataatt
    11941 tttctatatc atatataatt tttttaattt aagtttggac tatcatttca agtatattat
    12001 aacactttta ttagtccgtc tcaatttgtg tttttgccat gtcaaaacta tttttcatct
    12061 cttgattttt tgctggcgtt ggatcgggta gattatctaa atctaaagca ccagcatatt
    12121 ttgcaatcag atttgctatt aaatcagcca atccattcca gtcattgtcc aatatatacc
    12181 tcctctaaag ttttatatct aataattatt tgtttaatta agttttttga cattgacaag
    12241 tgctttggat tagcaacata ggaatctcac ctccgcctct attccggatg agcctgcttc
    12301 aaccttagaa gtatcattat cctcattttc ttcatagcgg atagggtatc cctccctata
    12361 ttcaaactct tacttatcgc tcactttctt tttgcttagc agaacttttt ttgccgaatt
    12421 attcagccga aagatcttga cggataggtt attacgctcc aaaaataatt aacgtcttgt
    12481 cttggtctat tcaattgtta aggttcaaaa tttatcgaga gttattaatc tttttaaaat
    12541 ttgaccatca gaaaatattt atcttgatgt aacaaaattc tataaattac cctcttatac
    12601 ttaacagtga aaagaagtct ttcttggtaa ccaattttga aatagaattt gcttatataa
    12661 aaaggtccaa ttcctactgc ataagtagca gtgaaaatta gaccctcttg gtaactgtca
    12721 tctaaaagtc ttctagcatt tctttaattt tctaatcgcc tttaaagtgt catatttata
    12781 tttttttatc tctggcatac tttgatacct ttttaaactt aaagtcttta atagtgcctt
    12841 tccacctctt tttatctata aagattctcc tacatcataa ttcatttttt tatttaaacc
    12901 tttctgtctt agtttgtctt tatcttcttc ataccatttt aagattgtca catagtggtt
    12961 ttgataggtc ttaccactgc tttccatgta tctggatagt ttatttatca ttatatctgt
    13021 gtgtgagttt aatttttctt ttagattttt atattcttct ttgcttaacc ttacattttt
    13081 gaattctcca taaaaaatgg gggtggactt tttatctatc tctccctctc tctctttatc
    13141 tatctctata tctttctcta tctctatctc ttgtcggaca tgggttggac tcattaagga
    13201 caatgtcctc tgtttatttt gtctgtatct tctttttttc tctgcccagg ctgtttctga
    13261 tccgattaag tttggtattt cagttaggta gtattcatca ttttctgtta caacttctaa
    13321 taagccttga ttgattaaat aatttactgt taccattaca tcatcgtctg tttcatctat
    13381 ggttagtgct aactctttta taaaatcact ttctactccg tcataataga gtttgccctc
    13441 atcttttagg cttagtagta gaagttttag gtagattatc gtataggtat ctcctccaga
    13501 tattctcctt aaccttttta tccttttgtc tgtgaaaaat tcttctttta attttatcca
    13561 atagtatctt ttgtttgttg ccatatctgc tcctttcttg attttcgata atcgaaattc
    13621 ttgatttccg attttcggaa ttctggactt ctgtttttcg gaagtcttgt tattatggtt
    13681 atttaagggt gtaacttttc gttactccct ttagatttct ctggtcatat cttttttgtt
    13741 tggttttact ttttctttta ctttcctttt tcctttttct tttgtcttat ctttgttttt
    13801 ggataggtct ttgtatttct ttatttgttt taggatactt tctttttctt ttttattttc
    13861 cttggctatg acttgcttaa aggcatattc cattactttt atgtctttgg cttggaagaa
    13921 tatttcatag tttttgcttt ctttgttttt cattactgag aaacttactc caagtttgtt
    13981 tagttctttt tttaagtctt tgaggtcgat ttgatctatg cttatatttt ctagttgtcc
    14041 tttcttgtag aggtctttta ttttcatttc atcgcccata agacttttta agtttccatt
    14101 tgctttttct aaagtttcat tcatcttttt tcttatttct ttttctaaat tgattgattc
    14161 ttttgttgcc tttattgtgt atgatattat ggtttgtgct gcttgacctg cttccttgct
    14221 tatttcttcg tttatcatgc ttttctctcc tttgtttgaa ttaaaaaagg gaagtatagg
    14281 ttttaatttt tctatacttc cctttgcttg tttttatttt attgttcttg gtggtggaat
    14341 actttatttt gatgttttta tatatttctt aggtctttgt accttttata cttttaaaaa
    14401 tagcttacac tacctttcca cctttaatag tttatgtgtg ttcttttgtc tgatagatag
    14461 tttttcatgt tagaatatat aatctgtatt tcttcattgt tcattgcttt tatttcttct
    14521 gtgcttttat aggttttgta tgttccatct tcatttgctt ttatgagttc atctattagc
    14581 tcttgccttt tattcatctc tattacctcc tagatctgac tttagttgtt tggtcatatt
    14641 atagcttgga taagatattt ttaccaggtc ttatctttct tgatccattt tcttgttttt
    14701 catcatttct ctgtattcat tatctttatt gacttggtct tggaactttt taatctgtgc
    14761 tattacactt ggtttttctc cctgttttat tagcttatct atttctatgg ataaatctat
    14821 accaagttct ttgtttacaa aatctactga atattttata tgattaattt cctggtattc
    14881 atcttttatc ttgtcttttt ctttatttat ttcttcaaga tttgacatta aaagaatttt
    14941 ttcttcattc cactttttag gacttagttt ttccttatct gataggagtt tttttaattt
    15001 cccacttact actttatatc ggtctatatc tttcttatgt ttgttataaa atgcttcttt
    15061 tgtgaatata tttttctttt gatattcttc ataaacttct tttttggctt tgtagatttc
    15121 atagtataga attttctttt ctacatcttc catttcttta tggattgtct ttgctttttt
    15181 atttagccta taactattag actttaaagt ttctattttt gtttgtaact gacctatggt
    15241 ttctatgttg ttttttctta aataactata tgcacttgtt agctttttga agtcatattt
    15301 ttctttatta gtttttgcat atccttttag atatttactt ttttcttttt gaatttctga
    15361 ataagttaat agataatttg ttagattaaa aagtttaggg ttgtctatta ccttatctct
    15421 ttctatatcc ttaaattttt cataagcagt agataagtta tctaataaat ttcctatcca
    15481 accctttaat gtttttatct cttcttttat tgtttttaca agttgattat attttcttat
    15541 ttctctatta tagtttccct tgtcagtttc tattcccttt ctttccattg cacttgctgc
    15601 tgatcctaaa tggattgtcg gtagataatc tgaattttgt cttttaaaac tcctatggtc
    15661 tactcttttt tctgctcctg ctctttctaa atatttgtta caaagatctg aaaaattttc
    15721 tctccatttt tctacattgc ctgtatcgtt ccaggttgtt agttctactt ttcttgtctt
    15781 tggttttcca tttttgttta atactttttc tcctttttca tctaggatat attctttttt
    15841 tgacttggct aagaactctc ctttttcgtt tattggtcgc attatggtca ttatatgaca
    15901 atggatattt ccatttttat cttgactctc atcatgaatt gcataatcta ctatcattcc
    15961 ttgtgatgtt aaattttctt ttatatatct ttcaaccagg tttttatttt cacttaaaga
    16021 taactctttt ggtagtccta ttatgaattg tcttgctagt tgtgcattag aatttttttc
    16081 tgccatttct actttattcc ataaggtaga cctatcatta aattcttttg gtatatgatc
    16141 aggcaatatt atatttttta ctaatatttt ttcttttctt gtgtagtcat gggttactcc
    16201 gtcccattca ttttttattt tttctccact tatatatgct gcacttgcta ctgcactttt
    16261 gccttttcct cttgatatta tgtttactga aaaatgaaaa ctgtctgcca tttttatcac
    16321 ttcctttctt tgttgtttta ggtggaggct taatagtttt tttatatcct ctttgtgaat
    16381 gagcgttttg aaatgataga ataaaaaaag ccgactactg aattaatttt tgttgtttca
    16441 gtatgtcggc ttaattgtta ctttcatttc aaattttaaa agtcaagggc gagccttagc
    16501 gagtttattt acccttgact tttaaaaagc gaatggttgt tgctccctgc aagggtttga
    16561 ctccgcagga cgcaagcacc ctttagggtg tataattgcg cccttgtaac caagggacaa
    16621 ttatgttatt tcatctttag atgatttttc tacattatca tctattcttt cttctaaaat
    16681 ttccattatg tttaatctta tttcttcatc atttaacgtt tttattaact tataaaattc
    16741 atcttttgtt aaatcaatac tttcttcaaa aatactttca aacactgcac ctttttctat
    16801 aagtcttttg tttcttgctt ttctttcttg ttcattaagt tttttcttca actgtctttt
    16861 ttgattttgt aattgcttaa tgctttcttc tttcttttca atctgttctt caatacttaa
    16921 tcttttactt gccatcatgt atcctttctt aaaataaaaa acgactagat ttttatttct
    16981 aatcgttctt attttaaata ttataatttg ctatattgca ttttaatttt aagtcttcta
    17041 tatatctttc catgtaattc caatctggag tacctctact gtctatcggt aatttaattt
    17101 tgatatctgg caatactgtg ctagatattt gatctttata ttcagtattt tttaaagctt
    17161 gcctaataat tgaagttaaa tagaatgcta cttctttatt caattcttta ttttttaatt
    17221 ttaaacaatg aattttcata tctaggcttg ctttatattt atgataaaag actgctccta
    17281 aaaatgaaac agatataaaa ttttcaaaaa ctctataatt tttatcatct atatcttcgt
    17341 agtaacctaa gataccattg tcaatatttg tagcactaat tctaggagtt tttccatcga
    17401 gtaaatatct ttttggaata gatgagcctg ttggtacttg actcgatttt cccttttttt
    17461 cggtaataaa tatttctttt tattttgttg tctgatattt ttcctacctg tcctttgtag
    17521 gatgagtatt ttctagattt tcttgaataa ctttttactt gaagttttag cttttgaact
    17581 agtcgttgta ctttcttttt gtttattatc agtcctgatc tttttaatat tgctgttatt
    17641 ctctatatcc tatttttcat tcatgatatt cttttactaa ttttatctta aattctgtgc
    17701 tgtatttgcc attaaaaaac tgacctcctt tagttagttt tttggcctaa cttttgaggg
    17761 tcagttcaaa atttgcgact tttaaatgaa ttccaatatt caattattaa gagttaacat
    17821 ggtgcttgcc aataggaatc attagaggcg aattggaaat agggtcacgt ataatttttg
    17881 cttcaagatt aaagatatct ttaactagtt tatcatttag tatatcttca ggctttccct
    17941 ctgcaacaag tttaccttct ttaattgcaa ataggtaatc agcgtatctt gctgttagat
    18001 ttatatcgtg caaaatcatg caaatggttg tcttatattt ttggtttaga tcagtcaaga
    18061 ggtctaatag ttctatttga tatgagatat ccaagtaagt agttggctca tctaaaagta
    18121 ggatacttgt atcttgggct agggctagag ctatccatac tctttgcctt tgacccccag
    18181 aaagttcttc aactaggtta tttgctagat cttcaacatt ggccttaacc attgatctgt
    18241 ttattatttc aaggtcatct tttccaagac tcttaaaagg ctttctgtag gggaaacgac
    18301 cacggcttac aagatcagct actgttattg attcagggat tattggagat tgaggtaata
    18361 tagctatgtg ttttgctaaa tctttttctt tataagaatt aattgattta ttatcaagca
    18421 atacttctcc ctctaatggc tttataagtc gagacaaggt tttaatgagt gttgatttcc
    18481 cacaaccatt tgacccaata ataactgata ttttttcttc aggtattttt atatttatat
    18541 tttccaagat tattttttca tcataaccgc aggtaagatt atttgaccac agacctttca
    18601 ttatatattc ctcctgttca tttttattag taagtatatt aagtatggtg aacctaacaa
    18661 gccagttaca acacctactg gatatctagc tggtaaaata ttttgagaga atatgtctga
    18721 taacaaaact agtaaaattc caaccaatcc agctaatatt gggcttcttt tcttgccaat
    18781 atttaaggct atgggaccag ctaaaaaaga tatacaagct attggtcctg taattgaagt
    18841 agaaaaagca gttaaagata cagcgcaaaa aattaaaaca agccttgaaa gctcgggatt
    18901 tgctccaagt ccgattgcta tttcttcacc aagttcaata atttctagtc ttttattaaa
    18961 aaataaaact aatatagtag caataatact tactattaga acaagaggta tgtcatctaa
    19021 ctttgtaaaa gataaagagc cactgagcca tctcataact tcttgtaatt catatcttgc
    19081 tactttcaac aataaaaatg aggtgcctgc tcttgtgaca gcttgaaaac caatacctaa
    19141 tattatcagt cttgctgctg aaaaaccatc ttttttagct agtaaaaata atattaaaga
    19201 tgatgttagt ccacaagtta ttgaaataat tccagtagtt aaactatttg tttttaatac
    19261 caatatgcaa aagaccgctg caatagatga agaacttgtg acaccgatta tatcaggact
    19321 tgcaagagga tttcttaaca tagtttgaaa gataaatcct gccaatccaa aagaccagcc
    19381 agctataatt cctgctaata attttggtaa tctaatttcc ataatcgaaa aactagctcc
    19441 aggaacagtt tcactattta agactttaat caaagttgaa aaagaataac tttcatctcc
    19501 gataagtaaa atgaaaaatg atagactgat tattattaat aaaaatagtg aggaaaatag
    19561 tgttattcta ttttttcttt tttgaatacc tataattaaa ttttgcatta gttattaacc
    19621 cctctatttt tcatagttac ataaataagt actggacccc cgattattgc agtaattatc
    19681 cctacttcaa tttcacctgg tttacctaac atacggccga ttatatcaca tataagcaag
    19741 agctctgcac ctataaaaga tgaagaaatg gtcattgtgc gtatatcttt gcttataaat
    19801 aagccacaaa agtgaggaac tataagacct acgaagccaa taggtccacc aattgcagta
    19861 atacttgaac ataaaagcac acttgcaatt attgcaagtg atcttatcct attaacatta
    19921 actccaagac caacagccat ttcatcaccc atagctaaag cgtttaaatc tgatgaaata
    19981 aatatagcta tcaagtgacc taaaattata aaaggtagta gtgtagatat agaagataat
    20041 gtagctgctc caaggctacc tatttgccaa aatctaaatt tgtctaagac gttattattc
    20101 ggtaaaatta aaaaacttac aaaactgctt aaagccatac taacacaagt tcctgataag
    20161 gctagtttta taggggtaag gcctgctttt ccgcttacag caatcgcgta tacaaaaatt
    20221 gcacttacta agccaccaat gattgcaaaa cttatatggc ttatgcttga tgaaattcct
    20281 aaaaaagaaa gaccaattac tacactaaga cttgctcctg tgtttatacc gagtatacct
    20341 ggatcagcta ttgggtttct agtaactgat tgcatcaata caccgcttat ggcaagacta
    20401 gaacctgcta aaattgcaaa aatagttcta ggtattcttt tatatataat tgatttaata
    20461 aaatcatcat ttgtattgcc cattccaaaa gctgctaaaa aatctctgat attaatttct
    20521 tttgttccaa gctttaatga caaaaatatt gtaataagaa gacctaggca gattacaaaa
    20581 attatgccta ggtttatttg ttttttattt cgcatttttg catgcatttc ctaaaatatt
    20641 taggtattct tcaatagtat agtttattga aagtggtgtt ggagtgcatg aggctgctaa
    20701 cggtgtatta tctggaatta cagcaacggc accattttta attgcattta ttttacctaa
    20761 aagaggatct ttttgtaaag cttcaagagt tttatcatca ccataagtta tgattacatc
    20821 agcatcattt atcttatttg cttcttctgc agaaatttcc tttgcaaaac tatcttcact
    20881 ctcaaattct tttaatgatt cagggaaaac tagacctaaa tctgttaaat aatttgctct
    20941 tggatctttg ctagtataaa tccagaattt tgatgtatct gcagcattaa tcatagtaaa
    21001 taatactttt tttcctttga tttttccttt gatttctgga tgtttttcta attctttgga
    21061 tatacgagct tcagtatttt tgattaactc atcaccttct ttttccatac ctaaggcttt
    21121 tgaatcaatt ttaatcatat ctctccataa agtttgccaa ggtttagatt tgtatgctgc
    21181 tacaggagca atttttgata gagtgtcata atcttcttta gttataccag aataacctgc
    21241 taagataaca tctggtttag aatttgatat tgcttcaaag ttaagtccat ccaaatcgtc
    21301 aaataggtta gctttaccat ttagttcttt gattttttct tctgtccatg gtaaaactcc
    21361 tttatcagca cttacaccgt aatttgcttt tgaaagtcca acaggaacta ttcctaaagc
    21421 taatgctaca tcatgatttc cccaagcaat agttgcaact ctttcaggtt ttttatctaa
    21481 tatagtttga ccgaaagcat gatctaaaac tattttatca agcgcatgct ctttagaagt
    21541 attttcttca tttttaacag aattagaaga acaagcgcta aaaactatac acatagctaa
    21601 aatagctatt agaaaaaatt tgtttttcat aaaaactcct taaacatatt tcaagtctat
    21661 tgtatcgata ataattatca ttgtcaatag atacagttac aaatttaata atataatttt
    21721 ttcaaaaaag gatctagttt ttatttttag ttaaattatg tctatatttt tcattaactc
    21781 atcaataaaa atttgtttgc taatatctct ttcttctgat tttgtttcaa ggattattgc
    21841 tacatcattc atatttttag gtaaatacca accatctggc ttatctgaat atcccttgaa
    21901 gcctaattga ttaaaagtag ttatttgacc agtaccttga ttgatgtttt cttcaacttc
    21961 attaaagcct aatacttctc ttgcataatc cttaacttga tcttctgtcc ttaaagtcat
    22021 tttctattcc tcgtcactaa aattatcttc aaaactaata atatcattag gagtgcaaga
    22081 taaagcctta catattcttt ctaaattctt aaatgtaatt ggtttatcct ttcccatttg
    22141 tgccataaca tttgttgtaa gtcctgccat agctattaca tctgttttct ttagtccttt
    22201 ttttgctaac tgtatccata atggtttata gttaagtgcc ataatatccc tctttttttc
    22261 ttcattagat ttatttaatt atagcataaa tattgatttc attcaatctt acattgattt
    22321 agtgatttgt tttagagaat ttgttgtgtt attccgtcct tattttgcca taaattgttt
    22381 taagtgggac ctcttatcct taccattttt acctcctaat tttgagtata aaaaagacga
    22441 tagagttttt aatttctatc gtctgagatt tacatattaa attttcatca caaaataaga
    22501 ctctttaaag aatctttaaa ttcattggta tgctgcttac aatatccatt attaaaatgg
    22561 atactataag cagcacacca actatttatt ttttgagttt taaactttgg tagaagtctt
    22621 gaactcctta tatttacata actatttgcc tctataacta ttatgacacg aaaccaacaa
    22681 gcaagttcaa gcacctccat atctttattc aaatgaggac taagatattc acaaacatta
    22741 tcataaacct ctttatcttt tttcataaaa gaggcataca acttagcaaa tttatcctaa
    22801 aattttttgt tgcctttatc aatcatttca acgctccttt aaatataaaa atgatcctat
    22861 caatctttat attgagccta ttttctaatt gataccttgc aagaaaggaa taatagctgt
    22921 tcctatacca agtaggaatg taataaatgc agaaagtcat atactgtcat tcttttctat
    22981 taaatcattt tgaagtgtct caaagcatcc atgatggctt cttctttttc aggtgtacac
    23041 tgtggaataa tttgtttatc ctttttagac ttgttgtaat gttctcgtaa ttctattcca
    23101 catttctttt ttatctgtgc aatatataat gtcgaaactt ttaattcaaa tttattccaa
    23161 acatattctt tgatttgagc atatgttgct ttgctctccg cacttgtcaa atccatctca
    23221 tccagctcaa tttcaacact tatatgctta tcgacatcga gtttggacaa aagtgctacc
    23281 gtctcgacgt gatgcgtttg aggaaataga tccaccggct ggactttctt caattcatat
    23341 cccaactctt ggtatagttt aatatcacgc gccatggttg cgacattgca ggagatatag
    23401 gcgatgcgat cggctcctgt ttgggcgctt gctttgataa agctttctgt caagcccttg
    23461 cgtggaggat caaccaagat aacggttggt tgaatcccat ctttaagcca attcttcata
    23521 gcattttcag ctgtgtcaca gacatagtgg gcgtttgaaa tattgttcag ctgagcattt
    23581 tttttactat tctcaaccgc ttctggaatc agttcaacac cgtagacttc tttgacatgc
    23641 ttggcgactg ataaaccaat ggttccaata ccagaatagg catcaataat cacgtcatct
    23701 ttttttaact ctgcaaagtc aatggctgtt tgatagagtt tctccgccat ttcagtattg
    23761 acttggtaaa aggctgggcc agcgatttgg aagtcatttc ccaacatctg gtccgtaata
    23821 tagtcttgac cataaagagt gcgccactcc ttaccaaaaa tcgcattggt attctggtcg
    23881 ttgatatttt gcatgacaga cacaatctct gggaactgct tgataacttg ttcaatcaat
    23941 tggtcaacac gaaaaacttt tggacgagtt gtcaccaaaa cgaccatgat ttgtcctgaa
    24001 tagtgaccac gacgcaccac aagattccga atcaatccag actgttcctt ttcgtcataa
    24061 ggttttaaat caaaacgacg gagcaggtct cgaagagcta ctacgacttg gtcaatgaca
    24121 ggatcctgga taaagaaatc ttcaaggggc atgaggttgt gcgaattctt acggaaaaat
    24181 cctgtttcca agacaccatt cactcgacga acgggcacct gcgccttatt gcgatacttg
    24241 actggatgtt ccataccaag cgtttcagca acttctacat ctgcaattcc agcaatcttg
    24301 tagagactgt ccttgacttg cttggtttta aacttgagct gttctggata agaaaggtgt
    24361 cctaaatccg cgattcctga acgcaggtaa gccaaatcta gatcttgatt acggtgtggt
    24421 gactggacaa ggtatttttc aacttttcca aagccaatct ttttattgac cttgaggaca
    24481 cgcatgagaa ttttttcact cggtaaagca ttctctacaa aaaagaccaa accatctacc
    24541 ttggcaactc ctgccccttc atgggtcaaa tcaacaattt caacttctac aatatcattt
    24601 ttctttaaca ttcttttctc tttctattgg ccgacaaaaa agacggcaac gttacggtta
    24661 ccatccatta taccatgaaa tttcttaaga accaaaactc ttgaagaagt tgacaagggc
    24721 ttgccagagg gagcttaaga agttaccacc gtcctctagc gccttatccg catcaaagtt
    24781 aaggttgata tttttaaaac tgtcgccagc ttgtgatacg atgctttgtt taaggtcatt
    24841 tagggtttta gtgaaatctg cattgctgag gatatcactc tttgagagat tcaaggcaaa
    24901 attgatgatg atattgatct ggtttcctgt tatgacctga tcaagtttgt aattttttaa
    24961 ggtatcttca acaatcttgc ggatatcttc ttctgtcaga tttcccttgc tttctttagc
    25021 tttggcgagt cctgacttga tatcagctag ggcaacgttt aatttattag catcatagcc
    25081 tgatttgtcc ttgttttcag cattgatatc tgacaaagcc tttagctctt cttgagccaa
    25141 atctttattg gcttgcggca ccttggctcc attagcttct agcaaatagt agatcccagc
    25201 caaagcactc tcacctgtaa ctggaatggg tgctgctaca gtgattttgg cgtgttccac
    25261 acccaaagtt acggctgcat ttcggtacat atcctgagtt accttagtga tgttttcagg
    25321 tgtttcaatc ttgacctcaa gtggcgattt gtcacctagc ttttgaatct tggctgatga
    25381 atacaactgt aagctagagt cattggccac attcatgatt ttagaataaa catcaggtgt
    25441 catggtcttg agttctttgg tatctgttga ggcattgtag cccagttttt taagagtttg
    25501 atttttttgg tcttcagata gggaagaacc taggacatat tcaggttgga cataggtttc
    25561 atcgataact ttttgaacat ctgttgctgc atggacgcta ttcatagctg ttactgccca
    25621 caagatcgca gcgctagtca gaaagagttt ctttctcata gggaatttcc tcctttactt
    25681 ctttagagta atatatctat cttaaagaaa acttataaca aaaacacctg gtctagccag
    25741 atgttgaaaa gagagtgaaa catttgatga tgtaaaggtt aagtcgtacc tgtctagaat
    25801 aataatagtt tcctccattt acatagagtt cagcaccgtg aaaaatggaa atggggtgaa
    25861 tataactata agtctttcca gtcgtattac caagcaaggg ggcaacagtc tcacgagagt
    25921 actgtttggc tagaaccaag gtattttcct tgccattttg ggcgataaaa tcgatatagg
    25981 caggtccaaa attataggct tgaacagctg tccagatatc tacacccttc ttctgcgcca
    26041 gatagagatt gcctgtcaga gtttgaatgc cttgccgaat gctagaggca ttatcattga
    26101 tggtgttggt ggaaccactt gcagactcac tagactgcat aacatcgcct tcttttcctt
    26161 ttgtttcagt ataaatcata gcaagcacaa gctcttcgtt tgctggggtg tctttttcac
    26221 tcaatatttc tcgcaccatg ggttgatagg tcatgacttg tttgacatct tgatgaacgc
    26281 ggtaagcttt atagccagca aaaaggaaga ctgctagtac aagcactctt cgaattcgtt
    26341 taaacattat ttactttgga tatcctcgat atttttgatt aagatagagt aggttccatt
    26401 ttcgttttgg ataaactcaa cagactcggc gtcttgatag acgttattgg gaacgatgag
    26461 ctcaattcca tttgataagg agagtttttg gttttcaaat ttctttaatt ggcgactgac
    26521 atcaatttca tcaaattgaa caggttctgg tacggcttct ttgacttggt caataaagct
    26581 caaacgagcc gtcagattgt tgtcaaaaag gtcattagcc aatttctcag gtgacaattc
    26641 attgctttct tctaggttgt tgaaaatagc tgatttgacc ttggattgaa attgaaaatc
    26701 atctgtgtta aaagattcag caattctctg ggctgttttt tccagttcct tgatagattt
    26761 tttaggagaa atcttaggag cgacagcaag aagattatct gaaaaatagt tcaaaaaagt
    26821 cccgttgtac ttgattcgtt tttcaatcag gtgatacttg ctactctgaa gattgaccac
    26881 caaggcctca tcagctcctg ttccaaatcc aggcaggtta ttctgagtta gcttgattgg
    26941 attatcaact tctcctccga ggtgggtcaa ggtctcccgc agggcaattc gcaagaaagc
    27001 gaaatgttct acaccttctt tagaaaattg aacaaaaatc aagtcattgg tcttgagatt
    27061 ttcagaaatg ctaaactcct ctttccagag attagccagc gttactgatg tctccaacaa
    27121 atcgtctgta atatgattga agaagggatt ttcttcttcg aaaatcccag tcttggcttc
    27181 atctgaatac acatgttcaa tttttttacg caggtattct tcgatttttg gagtaatatt
    27241 gagaaactta tctgctaaga acagttcggt atcatccgga ctgaactggt gaataatggc
    27301 tttcttaata taaatgtcca taaaagtttt agtcctcgta tagtaggaag gcatctgtca
    27361 attctttgac tgcacttctc acttcttcta atacagcctc attttctgaa ttcttaaggg
    27421 ttttaatgat gagttcagcc actttgcgac tttcttcttc accaaatcca cgtgcagtaa
    27481 tggctgctgc tccgatacga atcccacttg tcttgaatgg tgacaagctt tcgtaaggga
    27541 ttgagttttt atttaaggta atattgactt catccaacaa gttttgagca actttgccgt
    27601 tttctacaac tttagtcaca tcaacaagga agagatggtt ttcagttcca cctgaaataa
    27661 tacggaaatc agggtcttgc aagaagacat ctgccatagc cttgctgttc ttaattacat
    27721 tggcagcata ttccttgaag gctggatcca aaacttcttt gaaggaaact gccttagccg
    27781 ccacaacatg ctctaaagga ccgccctgaa tacctgggaa aatagctgaa ttgatttttt
    27841 tagcaagttc ttcgtcattg gtcaaaatca aaccaccacg aggaccacga agggttttgt
    27901 gggtcgttgt tgttgtgata tgagcgtatg gaactgggct tggatgaagg ccagccgcaa
    27961 ccaaaccagc gatatgggcc atgtccacca tgagcttcgc accgacagca tctgcgattt
    28021 cacggaattt tgaaaaatcg ataatttgag aatatgctga agcaccagct acaatcagtt
    28081 ttggttttac ttcttgggct tgtttcaaga tagcatcaaa gtctaagagt tccgtttcag
    28141 gatcaacact ataagaaaca aagttgtagg tttgaccaga gaagctaaca ggagccccat
    28201 gagtcaaatg accacctgat gccaaatcca ttcccataac cgtatcacct ggctcaatca
    28261 aggacatgta agccgcacag ttagcttggc ttcctgaatg tggttggaca ttggcaaatt
    28321 tagcaccgaa aatttctttt gcgcgttcaa tagcaagagt ctctacaacg tctactacat
    28381 cagttccacc ataataacgg cgtcctgggt aaccctcggc atatttattt gtcaagatag
    28441 acccttgagc tgccataaca gccttggaaa ctacgttttc cgaagcaatt aactcgatat
    28501 tattttgttg gcgttcttct tctttggcaa tagcattcca gagatcagca tcatatgctt
    28561 taaaatcatc tttgtcaaaa atcataggtc ttctccttta ttgtgtgact agtccattag
    28621 tttgatttta caataagaaa atcaaactaa aagatgcgaa taaaccgttt ctgcatttta
    28681 tcacaagtat agccaacttt ttcataaaat gcatgagcac ccagacgatg attggcagaa
    28741 tttaagcgga taaacccata accacatctt ttggcttctt gttccaaccc ttgtagtaaa
    28801 cttttaccga taccttcacc ttgcgcttga ggtgaaactg ctaaagctaa gatattaaat
    28861 cctgctttgg aatagagtga ttcgtaaact tcagcgtgga catatccaag taagacatga
    28921 ttagctgcat cctcatagcc aagtaggaaa tgatgggaat cctgagacag tctagctagt
    28981 tggctagccg tttcctctgg actaaaagta taacccaaag cctcttggtt gatgtcacat
    29041 atcgctttca catctgtttc ttgcaaatct cttagcattt caagcctcct caaaagaaat
    29101 ctctggcaac cgagcaagaa tatcttctcg tttaattgcg ccttggcgta agattttcac
    29161 cttgtctcca gacaaatcca caatagttga atcctgtcca gttagaaaag catcgtcttc
    29221 cagacccaga acctcttggt caaaatcctt cagaatttgt tcaaaggtta caccacttgc
    29281 ctgacctgag atattggcag acggcccaat caagggacct gtctctcgaa ttaaatccag
    29341 tgtgataggg tgactgggca tccgaaatcc aatagttgca aggtcagaat ttacccaata
    29401 gggaactcgg tcattggctt cgagaataat ggtcaaggga cctggcaaaa aggtctctac
    29461 aagtttttgt agataagctg gctgattctt agaaaagtgc aagatatcct ctaaagaggc
    29521 gatattgaga ttgagtgcct tatctctagg acgacgtttg agctggtaaa catggtcaac
    29581 tgctttttcg tctaaggcct tggcaaaaag accataaacc gtctctgtag gcagaatgac
    29641 agctccaccc ttttccaact cttgtctaat cctgtccatc atcaaccacg accatcctat
    29701 cttgaccaaa ttggtccttg agtgttcgaa ctcttttttc aggaagatgt ttcctaaaaa
    29761 gttcgggaac actttgacct tgcttgtatc caatttcaag gtaaatctta ccaccatcct
    29821 tgagatagtc ttttgcatct tccgcaattc tacagtaaat agctaggcca tcctcgtctg
    29881 caaagagagc tagatgaggc tccgaatgca aaacattcaa gcctacctct gactcatctt
    29941 cacgagagat atagggtgga ttggatacaa ttatatcata tttttcagaa atttctgcaa
    30001 aacaatcaga ttttttaaaa aatatattaa aattttgatc gctagcattc tctgatgcaa
    30061 gctctaaggc ctcttgagaa acatctgctg ctgtcactga ccaatctggt ctattttttg
    30121 ctagagcgag agcaatagct ccactacctg ttccaatatc cagaactgag agattcgtct
    30181 caagattttc agttagaata agctccacta actcctctgt ttctggacga ggaatcaaaa
    30241 cccgttcatc cacctttaaa tgcattccat aaaaatctgc ctgtccaatg atgtactgag
    30301 ctggcttgtg agctgctagt tgctggtaaa tatcttctac aaattgtttt tcttcctctg
    30361 ttgtcacctc ctgctggagg gcaaaaataa agtctgtaaa agatagattt ttcagactac
    30421 tatagacaaa agagaggctt tccgcttcct ctccttgtct tatcaactct tcttcaaaat
    30481 ttgaaaacaa ttgagctaat ttcattattt gtttaattct tctagttttt gtgtttggtc
    30541 ataaagcacc aaggcatcca caacttcgtc caatttacca gacaaaatcg tatctagttt
    30601 ttggagagtc aagccgatac ggtggtctgt gacacggttt tgtgggaagt tataagttcg
    30661 gatccgttct gaacggtcac cagtaccgat tgtcgactta cgctcagcgt cttgttcatc
    30721 ctgagcaatc tgagcaaagt ggtcagcgac gcgtgcacgg ataatcttca tagccttctc
    30781 gcggttcttc tgctgggtac gttcttcctg catctcaacc ttgatattgg ttggcaagtg
    30841 aacgatacgc acggcagtcg caaccttatt gacgttctgt ccaccagcac cagaggcgtg
    30901 atagatgtcg acacgaaggt cttttggatc aatgtcgtat tcaacctctt caacttctgg
    30961 cataacaaga actgtcgctg tcgaagtatg aacacggcct tggctttctg tcacaggaac
    31021 acgttgcaca cggtgggcac ctgattcata cttaagctta gagtatacag actgacctga
    31081 aaccatagca accacttctt tgaaaccacc gacaccattc atagaagcct ccatgacttc
    31141 aaagcgccag ccttgggctt cagcatactt ttggtacata gttagcaaat ctccagcgaa
    31201 aagtgccgct tcgtctccac cagctgctcc acggatttca aggatgatat tcttgtcatc
    31261 gtttggatcc tttggaagga gcaaaatttt cagtttttct tcatattctt ctttttcagc
    31321 cttggcatct ttgagttctt gcttggccat ttcttccaag tccgcatctc cacctgattc
    31381 cttaatcatc tcttcggcat cgacgatatt ttgaaggact tgtttatact cacggtaggc
    31441 tattacggtg tcacgattgg aggcttcttc ttttgaaagc tccataaaac gcttggtgtc
    31501 tgaaacgaca tcagggtcac tcagcaattc tcctagttct tcataacggt cttctacagc
    31561 ttgtagttga tcatagatgt tcatttttct tcattctcct tattgatttc aggggcaaaa
    31621 taatgtttac ggcaaaccga gatataggtt tcattaccac caatctggat ctgttctcca
    31681 tcgtaaacgg gcagtccatc ctgtgttcgc aacaccatgg tcgccttttt cttgcaatac
    31741 tgacagatgg tcttgatttc gtcaatcttg tccgctaaaa gcaagagata tttggaacct
    31801 tcgaacaatt cattgcgaaa gtcatttttc aagccaaaag ccatgacggg tatgtctaac
    31861 tcgtctacaa cacgagctag gtcgtaaaca tggtggcgtt tgagaaactg ggcttcatcg
    31921 accaaaacac agtaaggttt ttctggtagg tctcggatat agccaaagat atccgttgtt
    31981 tcctcaatcg caagggcagg gcgtttcatg ccaattcgac tcgacacata gccaacaccg
    32041 tcacgcgtat ccagagccga agtcataatg acaacacctt ttccttgctc ctcgtagtta
    32101 taggccactt tgagaatctc aatcgtctta ccagagttca tggtcccata acgataatac
    32161 aactgtgcca tgtttcttgc ttcacgtcca tttctaaatt tttgctacat tctagtatat
    32221 cataattttc tgaagcttta aacggcaaaa tgtggtaaaa tagaagaaat caaaaactag
    32281 tggaggaagc tattatgcca tttgtacgca tcgatttatt tgaaggacgc acgctcgagc
    32341 aaaagaaagc tcttgctaag gaagtaacgg aagctattgt ccgtaatact ggagcccccc
    32401 aatctgctgt ccatgtcatc atcaacgaca tgccagaagg aacttacttc ccacaagggg
    32461 aaatgcgtac caaataagct agcttaagca gaattgctta ggctttttca atctccaagt
    32521 aacatccatt gaagaaatag cctaaatttg ttacaatttg aaaggatact tggaaaaatt
    32581 tccaagaaaa gagctattta ttaaaggaaa cattatgatt acacgtgaat ttgataccat
    32641 cgctgctatc tctactccac taggtgaagg ggctattggt attgtccgcc tgagcggaac
    32701 aaacagtttt gctattgcgc aaaagatttt caaaggaaaa gacttgagtc aggttgctag
    32761 ccatacactt aactacggtc acatcgttga ccctctgact ggtaaagtca tggacgaggt
    32821 catgattggg gctatgaaat ctccaaaaac cttcactcgt gaagatatta tcgagattaa
    32881 cacccacggt gggattgcgg tgactaatga aattctccag ctagctatcc gtgaaggagc
    32941 tcgattggct gaacctggtg aatttactaa acgtgccttc ctaaatggac gtgttgactt
    33001 gactcaggct gaggcagtaa tggatatcat ccgtgctaag acagataaag ccatgaacat
    33061 tgcggtcaaa caactagatg gttctctttc tgacctcatt aacaataccc gtcaagaaat
    33121 cctcaataca cttgcccaag tcgaagttaa tatcgactat cctgagtatg atgatgttga
    33181 ggaagcgact actgctgttg tccgcgagaa aactatggaa tttgaacaat tgctaaccaa
    33241 tctccttagg acagcccgtc gcggtaaaat ccttcgtgaa ggaatttcca ctgccatcat
    33301 cggacgtccc aacgttggga aatctagcct cctcaacaat ctcttgcgtg aggacaaggc
    33361 tatcgttaca gatattgctg gtaccacacg tgatgtcatc gaagagtacg tcaacatcaa
    33421 tggtgtacct ctcaaattga ttgatacagc cggtattcgt gaaacagatg acatagtgga
    33481 acaaatcggt gttgagcgtt cgaaaaaagc cctcaaggaa gccgacttgg ttctactagt
    33541 gctaaatgcc agtgaaccac tgactgcgca agacagacaa cttcttgaaa ttagccaaga
    33601 taccaatcgc attattctac ttaataaaac cgacctgcca gaaacgattg aaacttcgaa
    33661 actacctgaa gacgttatcc gtatttcagt ccttaaaaac caaaacatcg acaagattga
    33721 agagcgaatc aacaacctct tctttgaaaa tgctggcttg gtcgagcaag atgctaccta
    33781 cttgtcaaac gcccgtcaca tttccctgat tgaaaaagca gttgaaagcc tacaagccgt
    33841 taatcaaggt cttgagctgg ggatgccagt tgatttgctt caagttgact tgactcgtac
    33901 ttgggaaatc ctcggagaaa tcactgggga tgctgctcca gatgaactta ttacccaact
    33961 ctttagccaa ttctgtttag gaaaataaga aaaatccatg atccttcatt cggtcatgga
    34021 ttttattgtc tttattagta atctggtctt aagacccctg ttacagttgc cttagttgct
    34081 tcgtagtcgc catctacgac aaccttgata atgcgtttgg catcttcttc tggtgctgga
    34141 acaagaggta gacgagtggg tccagcttca aatcccatat agttaagaat tgccttaact
    34201 ggagcaggac ttggataaga gaagagagca ttaaccttag gaatgaattt acgctgaatt
    34261 gctgcggctt tcttcatatc gctttctgca atcgcagtaa acatctcgtg catttcatcc
    34321 ccatttgtat gagaggcaac agaaataacc ccatccgccc caaggttcat ggcatggaaa
    34381 gcatctccat cctcacctgt ataaatcaag aactcttcag gcttgtgctc aatcaagtaa
    34441 gccatattag ccaagctagt acattctttg acaccgataa tatttggatg gtcagccaag
    34501 cgaagcatgg tttctggagt caattcgaca actacacgcc ctggaatgtt atagataata
    34561 attggtaggt cagaagcatc tgcaatagtc ttaaagtgct gatacatccc ttcttgagaa
    34621 ggtttgttgt agtaaggaac aatagcaagc ccagctgcga aaccaccaaa ttccgctact
    34681 tctttgacaa actcaataga gtcacgcgta tcattagtac ctacacccgc aatcaaagga
    34741 acgcgtccat tgacaacctt ttgtacagcc gcaaacaact ccaactcctc atcgtgggtc
    34801 aaagttggac tctcagcagt cgttcctgcg agaagaattc catccgtatg atgggccaat
    34861 aaatgctcaa tcaaggctgg aatagcatca aagttaatgg aaccatcctc atggaagggg
    34921 gtaataaagg ctgtaatgat tttacatttt tttaaatctt gataagacac gaaaacacct
    34981 ttctatttca aagaaggagt tcatctgaac tcctaaacga tatgactatt ttaattcaaa
    35041 tttcaattcg gctgttggac gaaccaatcc acgttcatga agagtttcag caatctgaac
    35101 tgagttccaa gcagcacctt tgagaaggtt atctgaaaca acccacatgt gaattccttt
    35161 ttctgcatcc aagtctttac ggatacgacc aacaaaggta tcacgcgaac caactgcatt
    35221 gatagcttga ggatagattt gatgagctac atcatcttca agaacagcac ctgggaaggc
    35281 tgcgatagct gcttttactt cttcgattgg agccacttct tttgtttcga tataaacaga
    35341 ctcagagtga gctgacaaga ctggaatacg cacacatgtt gcagatactg caatgctatc
    35401 atcttccata attttcttag tttccttggt catcttcatc tcttcgtacg tgtaatcatt
    35461 atcagtgaaa acatcaattt gtggaagagc gttaaaggcg ataggataat gtttcttgtc
    35521 accacctgaa ggcaagattt ccgcatgcaa atcacgtggt ttcacaccat cattcaagac
    35581 ttcacgaagt tcacgttgtg tctcaagaat tgctcccata ccagcacctg aaacggcttg
    35641 ataagttgaa acaatgatac ggtccaagcc ccatttttgg cgaaccggct caagagccac
    35701 catcatttga attgttgaac aattagggca ggcaatgatt ccgttgtgag catcaagtgc
    35761 atgagcattg acctctggaa caaccaaagg aacatctgga ttttgacgga aataagatgt
    35821 attatctact actaccacgc cagcttttac tgcgtatggt gcatacttag ctgatgtaga
    35881 actacctgct gaaaagagag caatatcaac tccttcaaaa gctgtttcag tcgtttcttc
    35941 aattgtaata tcttgatctt taaatttcaa tgacttacct gctgaacgtg cagaagcaag
    36001 gtaacgaatt ttatcgattg gaagtgttga ttcttccaac atttttatca tctgagcacc
    36061 gacagcacct gtcgcgccga ctacagcaac tgtatatccc ataaataacc tctttcggaa
    36121 ttttctaaaa atttctataa tagaagtatt atactacttt ttccatgaat tgcaaagctt
    36181 tttcatcatt ttttggaaaa taaaaatccc agtcgctaga ctagggacta agaggcatct
    36241 tcatgtgatg agcaggttca cacaactcat caaggtccgc tcctgcgtta tgacctcctc
    36301 atgctcaata gtagtccgaa gactacctat cgactcatcg catattctat attactagag
    36361 atacttgatt ttgtcaataa gaaatttttc agatcgagta taacaaaaaa ctctcgtatt
    36421 caagagtttc cctatacata tcatgctaat tgccgggatt gaaccggcga cctcatcctt
    36481 accatggatg cgctctgcca actgagctaa atcagcttac ttaagaagta tactatattc
    36541 agaaaaactt gtcaagtttc cttagaaatt ttccatagga aaaagccagg taaaaactac
    36601 ctagcttatc ttcttctatt tacttaaatc aattcgacga ccaattttac caataataat
    36661 cgctccaata atcaatgaag caaattcacc gattcctgtt gtaaaccaag taaggaagaa
    36721 tggtaattct gctacaatat ttaactctgc agcgatagta aacatggaaa ttgaaaagag
    36781 gattgaaaag aagaaatgat cttttcgaat caatccgtta aagaggtaat ccttgctata
    36841 ttttgcaaaa agccaaacac ctaaactgag gaatactaag gttgaaccac caccaacaaa
    36901 gacatctagc agtccgaagc taaagaaatt agcaatcata caaccgatgg taactccgat
    36961 gatgtactta ggattgtaaa aagccataaa gttcatcatt tctgaaatac gaaactgata
    37021 agcaccatag ctgatggcat ttaggggcgg tgtgacagtc aaaacgacgt agatagcagc
    37081 gacgattgca atatctgcaa catcacgaat agttaatttt ttcatctttt ctcctttggc
    37141 ggttatccgc gtgtaatatg cttggtgaaa gaagctaagc accaagggtt gattcattca
    37201 accttactag tatagcacaa tagcctgctt tatgctatac ttaaagcatg aaaaaaccta
    37261 ttcaaaaatt ttttaacaat gaaatcttag cctatctctt ttttggtata gtgactactc
    37321 ttgttgctat actatcacga ttagtcattt atcagctaag tcatcaggaa ctccttgcta
    37381 cggccttggc aaatattatc ggtatcctat ttgcctttat cacaaatgat acgattgtat
    37441 ttaagcaaaa aaagaaaaat agacttatcc gtttagtgaa attttctctt gcccgccttt
    37501 ctacttttct gttagacttg tttttaactt ttctctttgt aacccaattt cctcacatca
    37561 tagggcaatt cgtaactgaa aacattgata agataaatgc tattgaaaca ataattgcac
    37621 aaatattcat tattatcatc aattatatct tgagcaaggt ctatattttt agaaaataat
    37681 gctccattta tgagcctttt aattgccttc tataatgatt taggatacaa tgaaacacga
    37741 aacattgaaa ggaaaacagt atgttaaaaa atctaaaatc gttcttgctt cgaggaaatg
    37801 ttattgacct tgctgtcggt gttgtaattg cctctgcttt tggtgctatc gttacttcac
    37861 ttgtaaacga cattatcact cctcttattt taaatcccgc tttgaaagct gctaaagttg
    37921 aacgtatcgc tcaactttct tggcatggag tcggctatgg taacttctta agtgctatta
    37981 tcaattttat ctttgtgggt accgccctct tctttattat caagggcatt gaaaaagcac
    38041 agaagctgac tggcataaag gaagaaaaaa ctgacgaaaa aaaaccaacc gaattggaag
    38101 tccttcaaga aataaaagct ctccttgaga aaaaataatc gattaaaagg atctagcgca
    38161 aagctaaatc cttttttctt tactctttgg gtaacttgcc tgctttttca agcatttttt
    38221 tgataagata aggcatctta acattctccc gccctttttt ctcaatcagt tttttcacaa
    38281 attctggcat ttgtaaatct tcagattcag ctaaaatgtt tttcgtctcg tctgaaggaa
    38341 ctaactcatc aaaggtctct tcttctggga gaaattcctt aaactcttga ttttcattga
    38401 ctctaactgt attgaccaaa gcatcaatca aacgagaatc tgtatttggc attggtggac
    38461 gatggtagtt taccccaaat tcctggcata agtcataaca ttctacatca ttgtcaaaca
    38521 agacctcaat atgctcactg atgaaactaa taggtacaaa aatataatgg tctggatgtt
    38581 ctgtctgttc tctgagatac tccaaaacat ctggtttaat ccatggaata ccaatatcac
    38641 tctcactctg ccaagtgttg gtatattgtt ctgaactcaa gcccagtttt tcagcgacta
    38701 gcttgctatt ttcgaaaatt tggtctatat aaggatcacc aaagtccaag gcaaaaatgg
    38761 gcacactatg ggctgaaaag atgactttaa agctgtcttg ctttacttct tcttttaaaa
    38821 tcttagcaat ttcatctgcc caatagttta agagcgcttc ttcctgatac cagtccttaa
    38881 tgaccaaaaa ttgaatttgt ttgctttcta aaaatttttc atagcccatg acagagtaga
    38941 aagaataatg gggctccaaa atcaagcaaa tacactgttc aattccgtct gcttccattt
    39001 gaccgatcac atctggaata aagggactgg aaaacttatt agcaaagtag acactgtatt
    39061 catttcccag cctagcttct accaaggcaa cctcttgacg ggtaattttt tgcagaggcg
    39121 tgcctccaat tcgtacataa ttatcataga gagtctgaat ctcgtggtct tggggtctca
    39181 ccccacgacg aatatttgtg aaaaaatcag ctacaccttc aaaggtaatc tcttctggtg
    39241 aaccgaaggt catcattaaa attgcttttt tcatgactgc ttccttgtga tgtttttatc
    39301 aagtttattt tatcattaat tcatcgataa gtaaacgcta acatagggac attctcaatc
    39361 ttctgtcttt tgtttttctc ttctttctat gatacaatgg aaaaaataaa ttcaaaagga
    39421 gtttttttat gacttatcca aatctcttgg accgcttctt aacctacgtt aaggtcaaca
    39481 cgcgctctga tgaacactct actactactc caagtacaca gagtcaggtt gacttcgcaa
    39541 caaatgtcct aattcctgaa atgaaacgtg ttggactgca aaatgtttac tatctaccga
    39601 atggttttgc tattggaacc ttgccagcca acgatccgtc tttaacacgt aagattggtt
    39661 ttatatcgca catggatact gctgatttta atgctgaagg agtcaatcca caggtaattg
    39721 aaaactacga tggtggtgtg attgaactag ggaattctgg tttcaaactc gatccagccg
    39781 acttcaagag tcttgaaaaa tatccaggac aaacgctcat cacaacagat ggaacaagct
    39841 tactaggtgc tgatgacaag tcaggaattg ctgaaattat gacagccatt gaatatctaa
    39901 ctgctcatcc tgaaattaag cactgtgaga ttcgtgttgg ttttggtcca gatgaagaaa
    39961 tcggtgttgg tgccaataaa tttgatgcag aagattttga tgtggatttt gcctacactg
    40021 ttgatggtgg tccactaggt gaacttcagt acgagacttt ctcagccgct ggtgctgaat
    40081 tgcatttcca aggccgtaat gtccaccctg gtactgccaa agggcagatg gtcaatgccc
    40141 ttcagctagc aattgatttt cataatcaac ttccagaaaa tgaccgacct gagttaactg
    40201 aaggttacca aggtttttac catctaatgg atgtgacagg tagtgttgag gaggtgcgtg
    40261 caagctacat cattcgtgat tttgaaaaag atgcctttga agcgcgtaaa gcatccatgc
    40321 aatctatcgc tgataagatg aatgaagaac ttgggagcga ccgtgtcact ctcaacttga
    40381 cagaccagta ctacaatatg aaagaagtca ttgaaaaaga tatgactcca attaccattg
    40441 ctaaaaccgt tatggaagat ctaggtatca cgcctattat cgaaccaatc cggggtggaa
    40501 cagacggctc taagatttcc tttatgggaa tcccaactcc gaatatcttt gcaggtggcg
    40561 aaaatatgca cggacgtttt gaatacgtta gccttcagac tatggaacgt gcagttgata
    40621 ccatcattgg catcgtagct tataaaggct aaaaagacga ggtggctcag ctacttcgcc
    40681 tttcttttta ttctactggt ttttcttgat ttccagtagt tgtagaagat tctgttgttt
    40741 tattttctga agttgattca gcaggtttag aatctcttgt attgcttggt ttgttttcgt
    40801 cgctagcagt ttcaatgtta gattctgcag ttgcgtttgg ttggttctca gcactggtgt
    40861 tatcaccatt tgcttcagca tttcttgctg gacttgtttc ttcacttgcg ctagcttttg
    40921 actggatttg atgattcaaa actagaatag cttttgtcga ttcaagtaaa gctgttttgt
    40981 ctttactctt agcagaaagt tgatctaata atgcatccac cttatcaaag tccgcatcag
    41041 atccattatt actttctaaa taagagtgaa gcgacatgag aatatcgtag agtttttgat
    41101 agagtacaag tgtctgagga tcttgctcag cattttcctt ttcttgttga agggcgctag
    41161 cgatacgagt caaaacatct tttacctgac tgtttacttc atccaagtct gcatcagcct
    41221 tgtttgtggc agcttttaga ttttctactt cttctgccaa ggattgtctg attccttctt
    41281 catggatttg ttccaagagt tgatttgcct tgttcaaaag actttctact tcttccttgc
    41341 tatctgtcgc agattattgg ttgctatcta ccatgtactc ctaaaacagg agagttataa
    41401 tccaagatta caaggcctta cagaaataag aaatccagat aagacaatgt tcgtccaaga
    41461 cgctattcgc ttcgcacagc agcacggatt caatatgctt taattttaaa gtttaggtgt
    41521 caagacctct ttttagtgtg cccaaaattt agagaagtaa tcaatcaact aacttttatt
    41581 tttttcaaac tttcagtaaa ctgacctaaa gctaactcaa tctgtctttg tagatgcttc
    41641 tgctatcagc tagaagttga tctacttttg ccaagactgc cttctcatca aaagttccag
    41701 gttgatagtt ggattgcagg gatggaatct tgtttttcaa agccgcttca tatcccttag
    41761 tttgaacctt gatgtagtga ttgtggtcgc catgaggaat tacaaaacct tctgaatctt
    41821 cacttataat tcgattggca tcaaaaccat gaccatcttc ttcctcatgg tggacatgta
    41881 gtgacgtatt acttaataca gaactagaag aacttcctac ctcttccgtg ttagagtgtg
    41941 atgggggatt gttaagagat gacttaggaa tatagtgata gtgatcccca tgtcttacta
    42001 tataagcatc acctgtatct ctgacaatat cattagggtt aaagacatat gtggctgcta
    42061 attcacctgc cgacaagtca ctctcaggaa tgaaatgata gtgaccacca tgtggtacta
    42121 tagtaggttg aaatagaata tgagcaaatt gataagggga ttttaaagta atttctaaca
    42181 atgatttaga aactatgatg tgctattcta aattcaactc actatatata accatcatcg
    42241 gtagtataac gtccctgtaa ttttgctaca gatacttctg cactagctcc tttatcgtct
    42301 ttaccatgtt cttgtttttg gcgattgatt tcatcttttg ttcgtacatt ttctgcatga
    42361 gcttgatctt taaggtaaac ataatacttt ccatctacct taataatata tcctccctta
    42421 acctaactga cgatatcttg atctttcggc tgatagttgg gggctttcat taatagctct
    42481 tcactaaaga gcgcatcaaa aggaacttta ccattatagt agtgataatg atcgccatga
    42541 gaagttacat aaccttgacc tgtaatctta ataacaattt gttttgcttg aattccttct
    42601 ttttgactaa cctagtctgg agtcaaattt tcagtcttct tagtgtcttt attactgttt
    42661 acatatgaaa cacgattttt atctgtattg gcctgttagc tatgttggtt cagagcataa
    42721 acacacagac ttaaggaaag gataacaaca gatccagctg ctatatattt ctttttaaat
    42781 ttcataatta cctcatttct ataattattt atatgatgtc ttcattatta aatgattaaa
    42841 taaattaatt aaccaattaa ttaactagta aatattccac ctctttttaa gttgtatgtc
    42901 aagaaatttt atatattaat aataaaatga aattctccca aagtcagagt tttatttcta
    42961 acttttgaga gaacttcatt tttgattcag actttttcta ctgctattcc ttacgctatg
    43021 agatcagaca aattcttttt tatcacttct ccacttggca atcttaattc aatcgttcca
    43081 tccatattga atataacact atctaagcct aatccgtaac tagctgtaaa tttttctaat
    43141 ttttcttgta caggatctac tgctggagct tcctctaatg ctggatctaa catagggtca
    43201 ctccccacat tcccttctgg attcaacatt ccattatccg ttgagttttc tggttttaca
    43261 ggtttttcgt ttggtgcctc tggtaaagaa tctgctggtt tattttctgt tggttggttc
    43321 tcaactgttc cagtagatac ttttccattt tcagatggtt tattttcacc atttccttga
    43381 ggtgcttctc ctgtaaaatc tgccatattc tttttaatga cttctcccga tggtaaatat
    43441 aattcaattg ttccgtccat attaaacaag acattttcta gcttcatccc ataactttca
    43501 gcaaattttg ctactttttc ttgtacagga tccactgtag gaacttcttc taacgttgaa
    43561 ttactagtac tattcccagt ttcagaaagt ttttcttttt ctaccttctc actagtcttt
    43621 ggttcttcta ccttttcatc aagttttgag ttttcttgtg ctttattcct tttaaattgt
    43681 ggtagaatac ttggtttatc agtttgattt tctttttcca agataggtac ttccacaata
    43741 taagtcgatt gattgtccaa ataagcattt gccatgaagg ttacaggaat tttatttccg
    43801 gccgttctgg ttgttccttg gtttaatttc ggaatcggta atttgatttc accaacttta
    43861 tagttatttt ctaaataagc atttccatga aattcatcaa acactctgac taaagcatca
    43921 gttcctttag gcactgcaaa ttgagggttc actcttaaat aagtatcccc tgcatggaaa
    43981 ggatagaaaa tcgtttgact ggccattttg taagctaaag aggttggaac tgtaaatgta
    44041 ccatcataac ttacttctgg ataatctttt gaagcgatag tatacttaaa tgtttgtcct
    44101 ggtaaataag gttgatctaa ttcaaagttt gcaatattcc ctactccttc tccaaatact
    44161 ttaccagata ctttctccaa tacttttcca tctggtgtta ttaattttac tagcatattg
    44221 atacctaatt ttttctccaa ttcaggcgga aaactaaaag aaacgcgttt ttgaccattg
    44281 gctagagtaa agttttgatt attaaacgta ctatttttta acaaattaac aacattcgtt
    44341 aattcttctc cagtataaac tttattccct tcttttttag caactccttc ttcgggttta
    44401 aacagttcat agttactgtg agaatgacca attccaaccg gtttatgttc atcaatcgga
    44461 tctgcatgat ggtgatctcc atgcggataa ataatcgcat ttttttcttt attcacgaca
    44521 atactttcac gtttgacacc atattgtttc ataatgccag caattttttc ttcgattttt
    44581 ttatctaaat ctttcatttc tttggcatta cttggataat cctgttcatg agatgacaaa
    44641 gaatctaatc cattatgact agttttaact tcctctaaat gtttttgcgc agccttaatt
    44701 tgctcttctg tcaagtcctt cttgaagaaa taatgattgt ggtctccgtg actcatgaca
    44761 aaacctgatt catcttcagc gataatacga ttagcatcaa atccgtatcc atcttcttca
    44821 tgtttctcat gtgaagttcc tggattgatt ggaagagatg gagaaggtgt tgctagacta
    44881 ttgtttggaa gagtcggttg cccaatttga tttgattttg gaatgtaatg gaaatgatca
    44941 ccatgtctta caatataagc tgtagccgtt tcttcaacga tatcttttgg attaaaaata
    45001 taaccatcag atgctgaaga gagttcctta cttgtcgtta aagaagaagg attgcttgaa
    45061 agactgccta gactagacac tacttcatta ggttttgcat ttgtagaaac tgtagaacca
    45121 gttccactga taggcaccat tctggcaatc ttttcttcta aggcagaaag cttgctgtaa
    45181 ggaataaagt ggtaatggtc gccatgcgga atcgcaactc catttggtgt acgactgata
    45241 atcttagcag ggtcaaagac caggccatct gattcactgt aacgttgggc gctaggtgaa
    45301 tcatagagtt ccttcaaaag actctggaga ttttcagatt tatttgctgg cttgctagtt
    45361 gatccttttg ctacagattg cgtgttattg tcactagctg ttgaagaata gcttaactga
    45421 ctcggttgca tattttttcc agccagatgt gctttagctg ctgctaattc actagcagat
    45481 aaatcgcttt tgggaatgta gtgatagtga cctccatgag gaacgatata agcattaccc
    45541 gtatcttcga taatatcagc tggattaaag acataaccat catttgtcgt atatcgtccc
    45601 tgagaccttg ctacagcaac attagagtta accttctcat tatctttgac atgttcttgt
    45661 ttttgacgat tgatttcatc tttagttcga acattatcag catgagctgc atctttcagg
    45721 tagacataat attttccatc gaccttgatg atataaccac ccttgacttc attgacaata
    45781 tcagcgtctt taagttgata gtttggatcc ttcatcaaga gttcttcact aaagagggca
    45841 tcataaggaa ctttcccatt atagtaatga tagtggtcac cgtgtgacgt tacatagccc
    45901 tgatctgtaa ttttgattac aatttgctca gcctgaattc cttctttctg gctaacctgg
    45961 tctggtgtca agttttcact tttctgactt gactggctgc catccacata agagacacga
    46021 ttattgtcct tattttcctg cgaacgatgc tggtttagtg cataggcaca tagactcaag
    46081 gatacgataa cagctgatcc agctgctata tattttttac taaatttcat aaatccctca
    46141 tttcaataaa tgatgaagtt ttttctcaac ttcttttact ttattaaata gttttctaaa
    46201 ccggttattt aaccatttaa ttaaccagta aatagtttac tatttaaaat tacttttgtc
    46261 aagtttctgt tacgtttttc taaaaaagag aagtaacacg aaaggttact tctccataaa
    46321 atatgctcca ttcattttac tactgtatag gagccggttg actttctttt aacaaagcca
    46381 agagactatc tacttctgct gaaatagtgt tattatcttt cgttccgaga agaagactac
    46441 tttttagacc agtcaatgtc tccatagcat tttgtctaat actaggatct gttacttttt
    46501 ctagcaaggc ctccgcatct gctatcttag cgttaataac agaatgctct acttgaggaa
    46561 tttcagcctc atctgtagta tcttcagctt cttcctctgt ctcttccgta tcagtgcttg
    46621 gtttataaag attatctgct gaaggattta aaccagcgtg attctctttt tcatcagatt
    46681 cagggtgagt tggctcactt acttcatcat gtcccttatc ttcatcaggt ttttctgtct
    46741 gaggtttctc cgtttgattg gtatcagctt gaccattttt gtttctttga acatggtcgc
    46801 tagcgttacc aaaaccatta tctgaatgcg gacgttcgtt tggatgttcg acatagtact
    46861 tgacagtcgc caaaagatcc tcaagagtat accccttagg tgcctcataa aggccttcgt
    46921 caaaccactc aaatttgatg ttatggtaat ggtcataatg aggtatgatt aaactaccgt
    46981 ttttgacttc tacagtatat tgaagattgt aaggcatgcg atcaagtggc accttcttag
    47041 ctgctttcac gcggttgtag atagcttctg ctccttttgc ctcagtattt cctgaatcct
    47101 gatggtctgt cgaaggaggg gtcaaacctt tctctttagc ataagcctgg gctgccgctc
    47161 tttcagcttc agacaaacta tcttttttaa tccagtggct atgggtcata tgtggagtta
    47221 cataggcatc cccctcatca ctggttatat cacgaggatc aaagatataa ccgtcttctg
    47281 ttgtgtactt gcctgccaac ttggctactt gaatctcatc atcagtgtag gtaatttgcg
    47341 catttggttt tcctaaacgt tctggatgac gaatcggagc taagaaggca agaatatctt
    47401 ccactaactt gactttatca cttgagacat ccttgagtcg ttccaacagg ttatccaaag
    47461 cctcaaaatc aacttgtcga cctttattat caagtaaatc ttggtgaatt cttgctagta
    47521 agtcataagc cttattgtaa aattctcgat cactagatgg gaggtcagtt ttcttagctc
    47581 ctagcttatg agataaactt tcctgcttgg ccagtttgct atcaatgcct gctgctgttt
    47641 ctgctgaaag atccttggct gggatataac gagaaactcc attctcctca aagacataac
    47701 catcgcctac ttttcgaaca gcttctttga ccaatttctc atcaattgga ttgcttggag
    47761 ctggttgagg atttggtgca ggttgcggac ttggactagg ttctggagtc ggttgtggac
    47821 ttggttgttc tggtcttgaa tctggtaccc aatggtttga acgataacga aggggaataa
    47881 tacgagcaat tcgtttttcc aattcagaca tttgttcata agggataaag tggtaatggt
    47941 taccatgagg gacagctaca cctctggctg ttcgacttgt gatttgcgct gggtcgaaaa
    48001 caaggccatc agattctaca tggcgttgac tcaaaggcag tttgtagagc tgtttcaaga
    48061 gactatcaat gtcattactt tgacttgctt gactgttagt gttgctgttg ttgcttgtgt
    48121 tagtatttgt agttcctgga ttgcttacag aaggtaccca gtttgttctt gaagtgttat
    48181 cgctattttg tcggcgatag gttcttgaat ttgacagatt tccccgacca gataggaagg
    48241 cttctgcagc agctaactcg ctagctgata actcattctt aggaatgtaa tggtaatg
//
LOCUS       DBERMM010000012        46885 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.012, whole genome shotgun sequence.
ACCESSION   DBERMM010000012 DBERMM010000000
VERSION     DBERMM010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 46885)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46885)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46885
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.012"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            233..463
                     /gene="blpU"
                     /locus_tag="ACL8AS_000895"
     CDS             233..463
                     /gene="blpU"
                     /locus_tag="ACL8AS_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HGS1228777.1"
                     /translation="MNTKKMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAVRGLQ
                     LGIKTRTWQGAATGAVGGAILGGVAYAATCWW"
     gene            466..591
                     /locus_tag="ACL8AS_000896"
     CDS             466..591
                     /locus_tag="ACL8AS_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="HGS1228778.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            1178..3331
                     /gene="comA"
                     /locus_tag="ACL8AS_000897"
     CDS             1178..3331
                     /gene="comA"
                     /locus_tag="ACL8AS_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="HGS1228779.1"
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKT
                     TMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTG
                     QDKDSIHIADPDPGVKLTKLPRDRFAEEWTGVTLFMAPSPDYKPHKEQKNGLFSFIPI
                     LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIL
                     QQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSII
                     DALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNR
                     DTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQK
                     ALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQT
                     AQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVP
                     QGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQ
                     PYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISG
                     GQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAE
                     RTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS"
     gene            3344..4693
                     /gene="comB"
                     /locus_tag="ACL8AS_000898"
     CDS             3344..4693
                     /gene="comB"
                     /locus_tag="ACL8AS_000898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence pheromone export protein ComB"
                     /protein_id="HGS1228780.1"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKE
                     MSLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESY
                     ASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
                     ETIASQNAAASQTQAEIGNLINQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYK
                     SQGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQ
                     HLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEG
                     ALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSID
                     ATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            4863..5570
                     /gene="purC"
                     /locus_tag="ACL8AS_000899"
     CDS             4863..5570
                     /gene="purC"
                     /locus_tag="ACL8AS_000899"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HGS1228781.1"
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAG
                     KGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSK
                     RFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINEL
                     LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLG
                     ELTDVYEIVWEKLQGLK"
     gene            5627..9352
                     /locus_tag="ACL8AS_000900"
     CDS             5627..9352
                     /locus_tag="ACL8AS_000900"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004642 -
                     phosphoribosylformylglycinamidine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HGS1228782.1"
                     /translation="MDKRIFVEKKADFQVKSESLVRELQHNVGLSSLKSIRIVQVYDV
                     FDLAEDLFAPAEKHIFSEQGTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQE
                     ALLLLGSSSDVTVNTAQLYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFS
                     ESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVL
                     DTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMA
                     TIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
                     GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGY
                     SSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGK
                     TGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDF
                     GAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDAFVA
                     ECNKENIDAVVVAIVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVDAKVVDKDVKL
                     PEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEA
                     SVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEATARLVAAGANWSKARF
                     SYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLV
                     AFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEAIQADHKVT
                     SASAVKYGGVVESLALATFGNYIGAEVTLPELETALTAQLGGFVFTSPEEIAGVEKVG
                     QTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKE
                     KVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDK
                     TNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVK
                     SGLLPYGNFEVANSTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVS
                     HGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQI
                     IGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK"
     gene            9445..10887
                     /gene="purF"
                     /locus_tag="ACL8AS_000901"
     CDS             9445..10887
                     /gene="purF"
                     /locus_tag="ACL8AS_000901"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004044 - amidophosphoribosyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HGS1228783.1"
                     /translation="MTYEVKSLNEECGVFGIWGHPDAAKLTYFGLHSLQHRGQEGAGI
                     LSNDQGKLKRHRDMGLLSEVFRNPANLDKLTGTGAIGHVRYATAGEASVDNIQPFLFR
                     FHDMQFGLAHNGNLTNAASLKKELEDRGAIFSATSDSEILAHLIRRSHNPSLMGKIKE
                     ALSLVKGGFAYILLFEDKLIAALDPNGFRPLSIGKMANGAVVVSSETCAFEVIGAEWI
                     RDLKPGEIVIIDDEGIQYDSYTDDTQLAICSMEYIYFARPDSNIHGVNVHTARKRMGA
                     QLAREFKHEADIVVGVPNSSLSAAMGFAEESGLPNEMGLIKNQYTQRTFIQPTQELRE
                     QGVRMKLSAVSGVVKGKRVVMVDDSIVRGTTSRRIVQLLKEAGATEVHVAIGSPALAY
                     PCFYGIDIQTRQELIAANHTVEETRQIIGADSMTYLSIDGLIESIGIETDAPNGGLCV
                     AYFDGDYPTPLYDYEEDYRRSLEEKTSFYK"
     gene            10924..11946
                     /gene="purM"
                     /locus_tag="ACL8AS_000902"
     CDS             10924..11946
                     /gene="purM"
                     /locus_tag="ACL8AS_000902"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004641 -
                     phosphoribosylformylglycinamidine cyclo-ligase activity
                     [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HGS1228784.1"
                     /translation="MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFG
                     GMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPL
                     YFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
                     GVAEKSQIIDGSKVVEGDVLLGLVSSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLK
                     EVLLEPTRIYVKAVLPLIKEELVNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVL
                     PIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLDEAVYEIGRIVKKEN
                     ESVIIK"
     gene            11943..12488
                     /gene="purN"
                     /locus_tag="ACL8AS_000903"
     CDS             11943..12488
                     /gene="purN"
                     /locus_tag="ACL8AS_000903"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004644 - phosphoribosylglycinamide
                     formyltransferase activity [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HGS1228785.1"
                     /translation="MKKIAVFASGNGSNFQVIAEEFPVEFVFSDHRDAYVLERAKQLG
                     VLSYAFELKEFESKADYEAALVELLEEHQIDLVCLAGYMKIVGPTLLSAYEGRIVNIH
                     PAYLPEFPGAHGIEDAWNAGVGQSGVTIHWVDSGVDTGQVIKQVRVPRLADDTIDRFE
                     ARIHEAEYRLYPEVVKALFTD"
     gene            12572..13081
                     /locus_tag="ACL8AS_000904"
     CDS             12572..13081
                     /locus_tag="ACL8AS_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000894002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HGS1228786.1"
                     /translation="MLESKKTTRYVFYVYLMLLTWGILFKFETNPEFIAFFLAPRYIN
                     WIPFSEPLIVDGKIVFAEMLFNLISFIPLGVCFPLIKTNLSSLRIVGTGFLISLLFEC
                     LQYILAIGITDITDLTLNTLGVCVGLLIYQIFIRVFKSQTRKWINILGMLSLGFAYLV
                     LLLLHLIGV"
     gene            13106..14653
                     /gene="purH"
                     /locus_tag="ACL8AS_000905"
     CDS             13106..14653
                     /gene="purH"
                     /locus_tag="ACL8AS_000905"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0003937 - IMP cyclohydrolase activity
                     [Evidence IEA];
                     GO_function: GO:0004643 -
                     phosphoribosylaminoimidazolecarboxamide formyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HGS1228787.1"
                     /translation="MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGV
                     DTIAIDDMTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNL
                     YPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELSAN
                     GETTYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQAMRYGENP
                     QQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDRPTVVALKHM
                     NPCGIGQADNIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSY
                     TDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQV
                     VTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQA
                     KDRLNGAVLASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFT
                     GVRHFRH"
     gene            14775..16037
                     /gene="purD"
                     /locus_tag="ACL8AS_000906"
     CDS             14775..16037
                     /gene="purD"
                     /locus_tag="ACL8AS_000906"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA];
                     GO_process: GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HGS1228788.1"
                     /translation="MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLEL
                     VNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKAFGPTRAAAELEW
                     SKDFAKEIMVKYGVSTAAYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVSETV
                     EQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFVNGDKFYIMPTAQDHKRAY
                     DGDKGPNTGGMGAYAPVPHLPQSVVDTAVDTIVKPVLEGMIKEGRPYLGVLYAGLILT
                     ADGPKVIEFNARFGDPETQIILPRLTSDFAQNITDILDSKEPNIMWTDKGVTLGVVVA
                     SKGYPLDYERGVELPAKTEGDVITYYAGAKFAENSRALLSNGGRVYMLVTTADTVKEA
                     QASIYQELYQQKIEGLFYRTDIGSKAIK"
     gene            16294..16410
                     /locus_tag="ACL8AS_000907"
     CDS             16294..16410
                     /locus_tag="ACL8AS_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HGS1228789.1"
                     /translation="MKERLDDNPIVQGNWKTLGFQFRHETPLVAAAVPHKLR"
     gene            16440..16928
                     /gene="purE"
                     /locus_tag="ACL8AS_000908"
     CDS             16440..16928
                     /gene="purE"
                     /locus_tag="ACL8AS_000908"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009567721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009320 - phosphoribosylaminoimidazole
                     carboxylase complex [Evidence IEA];
                     GO_function: GO:0004638 - phosphoribosylaminoimidazole
                     carboxylase activity [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HGS1228790.1"
                     /translation="MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPD
                     LMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYSI
                     VQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
                     LI"
     gene            16915..18006
                     /gene="purK"
                     /locus_tag="ACL8AS_000909"
     CDS             16915..18006
                     /gene="purK"
                     /locus_tag="ACL8AS_000909"
                     /EC_number="6.3.4.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004638 - phosphoribosylaminoimidazole
                     carboxylase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide
                     synthase"
                     /protein_id="HGS1228791.1"
                     /translation="MSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPASRV
                     AEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNR
                     IFEKDFLSNKAQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEAD
                     LEAAYALADSADCVLEEFVNFDLEISVIVSGNGKEVTFFPVQENIHRNNILSKTIVPA
                     RISESLVDKAKAMAVRIAEQLNLSGTLCVEMFATDDDVIVNEIAPRPHNSGHYSIEAC
                     DFSQFDTHILGVLGAPLPVIKLHAPAVMLNVLGQHVEAAEQYVTENSSAHLHMYGKIE
                     AKHNRKMGHVTLFSDVPDSVDELGEGIDF"
     gene            18016..18243
                     /locus_tag="ACL8AS_000910"
     CDS             18016..18243
                     /locus_tag="ACL8AS_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HGS1228792.1"
                     /translation="MIQIIVNTFIEKDKTGAVVEVLYASADQDKVQAKYEELAAQYPE
                     NYLAIYDVPLDTDLNTLDHYPSVFIEKEEFE"
     gene            18306..19604
                     /gene="purB"
                     /locus_tag="ACL8AS_000911"
     CDS             18306..19604
                     /gene="purB"
                     /locus_tag="ACL8AS_000911"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP
                     AMP-lyase (fumarate-forming) activity [Evidence IEA];
                     GO_process: GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HGS1228793.1"
                     /translation="MINRYSRPEMANIWSEENKYRAWLEVEILSDEAWAELGEIPKED
                     VALIRKKADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAY
                     GYLYKQANDIIRRDLENFTNIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSE
                     MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRAQEISTQVLPRDL
                     HAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSEN
                     MTGLARVIRGHMITAYENVALWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNL
                     TVFPENMIRNMNSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAYSWDNQVDFKPL
                     LEADSEVTSRLTQEEIDEIFNPVYYTKRVDDIFERLGLGD"
     gene            complement(19659..23597)
                     /gene="strH"
                     /locus_tag="ACL8AS_000912"
     CDS             complement(19659..23597)
                     /gene="strH"
                     /locus_tag="ACL8AS_000912"
                     /EC_number="3.2.1.52"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored beta-N-acetylhexosaminidase StrH"
                     /protein_id="HGS1228794.1"
                     /translation="MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTEN
                     QPTIHTVSDSPQSSENRTEETPKAVLQPEAPKTVETETPATDKVASLPKTEEKPQEEV
                     SSTPSDKAEVVTPTSAEKETANKKAEEASPKKEEAKEVDSKESNTDKTDKDKPAKKDE
                     AKAEADKPETEAGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTD
                     LHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTD
                     LINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKKSARTVDLDNEQAV
                     AFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYE
                     KFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVAS
                     SKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIP
                     IIGGMVAAWADTPSARYSPSRLFKLMRHFANANAEYFAADYESAEQALNEVPKDLNRY
                     TAESVTAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEALKEEEAKR
                     EVEKLAKNKVISIDAGRKYFTLNQLKRIVDKASELGYSDVHLLLGNDGLRFLLDDMTI
                     TANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSP
                     GHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKI
                     FNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYE
                     DKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYILGQKPEDGGG
                     FLKKAIENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFA
                     DHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTL
                     VANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAG
                     QENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGAPVTHKGDESG
                     LAPTTEVKPRLDIQKEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADG
                     KEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPA
                     EESKALPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED"
     gene            complement(23912..24628)
                     /locus_tag="ACL8AS_000913"
     CDS             complement(23912..24628)
                     /locus_tag="ACL8AS_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HGS1228795.1"
                     /translation="MAIPKYQYIKDELKNKIISGQFSSGDKFYTEAELISMYDVSSIT
                     VVRALNDLAKDGYIVRQQGKGTFVSRARKHKLVEFSDIELFNAKDDKVTVLSIERGNK
                     LVYLEKLGLRGDQFYYKIERIRESNGVVYIYHTSYIPEQYINANYPNLEYYSSIYNRF
                     KLDYHIHMNDEHFEEINEIVFPTPEHAASVLGVDEQFPTVLQTKITKLESTGQVLEYS
                     ETYKRSDYYKIKFISCDRDH"
     gene            24976..26763
                     /locus_tag="ACL8AS_000914"
     CDS             24976..26763
                     /locus_tag="ACL8AS_000914"
                     /EC_number="3.2.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-galactosidase"
                     /protein_id="HGS1228796.1"
                     /translation="MTRFEIRDDFYLDGKSFKILSGAIHYFRVPPEDWYHSLYNLKAL
                     GFNTVETYVAWNLHEPREGEFHFEGDLDLEKFLQIAQDLGLYAIVRPSPFICAEWEFG
                     GLPAWLLTKNMRIRSSDPAYIEAVGRYYDQLLPRLVPRLLDNGGNILMMQVENEYGSY
                     GEDKAYLRAIRQLMEECGVTCPLFTSDGPWRATLKAGTLIEEDLFVTGNFGSKAPYNF
                     SQMQEFFDEHGKKWPLMCMEFWDGWFNRWKEPIITRDPKELADAVREVLEQGSINLYM
                     FHGGTNFGFMNGCSARGTLDLPQVTSYDYDALLDEEGNPTAKYLAVKKMMATHFSEYP
                     QLEPLYKESMELDAIPLVEKVSLFETLDSLSSPVESLYPQKMEELGQSYGYLLYRTET
                     NWDAEEERLRIIDGRDRAQLYVDGQWVKTQYQTEIGEDIFYQGKKKGLSRLDILIENM
                     GRVNYGHKFLADTQRKGIRTGVCKDLHFLLNWKHYPLPLDNPEKIDFSKGWTQGQPAF
                     YAYDFTVEEPKDTYLDLSEFGKGVAFVNGQNLGRFWNVGPTLSLYIPHSYLKEGANRI
                     IIFETEGQYKEEIHLTRKPTLKHIKGENL"
     gene            26760..27236
                     /locus_tag="ACL8AS_000915"
     CDS             26760..27236
                     /locus_tag="ACL8AS_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1228797.1"
                     /translation="MTIVGCRIDGRLIHGQVANLWAGKLNVSRIMVVDDEVVNNDIEK
                     SGLKLATPPGVKLSILPVEKAAANILAGKYDSQRLFIVARKPDRFLGLVEAGVPLETL
                     NVGNMSQTPETRSITRSINVVDKDVEDFHKLAEKGVKLTAQMVPNDPISDFLSLLK"
     gene            27264..28169
                     /locus_tag="ACL8AS_000916"
     CDS             27264..28169
                     /locus_tag="ACL8AS_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HGS1228798.1"
                     /translation="MIQWWQILLLTLYSAYQICDELTIVSSAGSPVFAGFITGLIMGD
                     VTTGLLIGGNLQLFVLGVGTFGGASRIDATSGAVLATAFSVSQGIDAPLAITTIAVPV
                     AALLTYFDVLGRMTTTFFAHRVDAAIERFDYKGIERNYLLGAIPWALSRALPVFFALA
                     FGGAFVQSVVDFVEAYKWVADGLTLAGRMLPGLGFAILLRYLPVKRNLHYLAMGFGLT
                     AMLTVLYSYVTGLGGAVAGIVGTLPAEVAEKIGFVNNFKGLSMIGISIVGIFLAVLHF
                     KNSQKVAVAAPSTPSESGEIEDDEF"
     gene            28156..28971
                     /locus_tag="ACL8AS_000917"
     CDS             28156..28971
                     /locus_tag="ACL8AS_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HGS1228799.1"
                     /translation="MTNSNYKLTKEDFNQINKRSLFTFQLGWNYERMQASGYLYMILP
                     QLRKMYGDGTPELKEMMKVHTQFFNTSPFFHTIIAGFDLAMEEKDGVGSKDAVNGIKT
                     GLMGPFAPLGDTIFGSLVPAIMGSVAATMAIAGQPWGIFLWIAVAVAYDIFRWKQLEF
                     AYKEGVNLINNMQSTLTALIDAASVLGVFMMGALVATVINFEISYKLPIGEKMIDFQD
                     ILNQIFPRLLPAIFTAFIFWLLGKKGMNSTKAIGIIIVLALALSALGHFALGM"
     gene            28978..29382
                     /locus_tag="ACL8AS_000918"
     CDS             28978..29382
                     /locus_tag="ACL8AS_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HGS1228800.1"
                     /translation="MTKSLILVSHGRFCEELRGSTEMIMGPQDNIYTVALLPEDGPEE
                     FTAKFEAVIEGLDDFLVFADLLGGTPCNVVSRLIMEGRDIDLYAGMNLPMVIEFINAS
                     LTGADADYKSRAAESIVKVNDLLAGFDDDEDE"
     gene            29681..30847
                     /locus_tag="ACL8AS_000919"
     CDS             29681..30847
                     /locus_tag="ACL8AS_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA];
                     GO_process: GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HGS1228801.1"
                     /translation="MLHYTKEDLLELGAEITTREIYQQPDVWREAFEFYQAKREEIAA
                     FLQEIADKHDYIKVILTGAGTSAYVGDTLLPYFKEVYDERKWNFNAIATTDIVANPAT
                     YLKKDVATVLVSFARSGNSPESLATVDLAKSLVDELYQVTITCAADGKLALQAHGDDR
                     NLLLLQPAVSNDAGFAMTSSFTSMMLTTLLVFDPTEFAVKSERFEVVSSLARKVLDKA
                     EDVKELVDLDFNRVIYLGAGPFFGLAHEAQLKILELTAGQVATMYESPVGFRHGPKSL
                     INDNTVVLVFGTTTDYTRKYDLDLVREVAGDQIARRVVLLSDQAFGLENVKEVALGCG
                     GVLNDIYRVFPYIVYAQLFALLTSLKVENKPDTPSPTGTVNRVVQGVIIHEYQK"
     gene            30963..32000
                     /locus_tag="ACL8AS_000920"
     CDS             30963..32000
                     /locus_tag="ACL8AS_000920"
                     /EC_number="5.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016857 - racemase and epimerase activity,
                     acting on carbohydrates and derivatives [Evidence IEA];
                     GO_function: GO:0030246 - carbohydrate binding [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase family protein"
                     /protein_id="HGS1228802.1"
                     /translation="MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVA
                     PDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNAS
                     NCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEI
                     SYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSIAPDGVPAKTPEAN
                     RDVVKHVYNGTLLKDIFAEEDEQIQLASGLDHPFALPAGHDNAGFLYDQNSGRFLLFK
                     TEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHSDLKGQVILKAGQTF
                     TSKTRYELVVK"
     gene            32117..33330
                     /locus_tag="ACL8AS_000921"
                     /pseudo
     CDS             32117..33330
                     /locus_tag="ACL8AS_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041867.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CAP domain-containing protein"
     gene            33782..39352
                     /gene="zmpC"
                     /locus_tag="ACL8AS_000922"
     CDS             33782..39352
                     /gene="zmpC"
                     /locus_tag="ACL8AS_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000088129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease ZmpC"
                     /protein_id="HGS1228803.1"
                     /translation="MSRKSIGEKRHSFSMRKLSVGLVSVTVSSFFLMSQGIQSVSADN
                     MESPIHYKYMTEGKLTDEEKSLLVEALPQLAEESDDTYYLVYRSQQFLPNTGFNPTVG
                     TFLFTAGLSLLVLLVSKRENGKKRLVHFLLLTSMGVQLLPASAFGLTSQILSAYNSQL
                     SIGVGEHLPEPLKIEGYQYIGYIKTKKQDNTELSRTVDGKYSAQRDSQPNSTKTSDVV
                     HSADLEWNQGQGKVSLQGEASGDDGLSEKSSIAADNLSSNDSFASQVEQNPDHKGESV
                     VRPTVPEQGNPVSATTVQSAEEEVLATTNDRPEYKLPLETKGTQEPGHEGEAAVREDL
                     PVYTKPLETKGTQGPGHEGEAAVREEEPAYTEPLATKGTQEPGHEGKATVREETLEYT
                     EPVATKGTQEPEHEGEAAVEEELPALEVTTRNRTEIQNIPYTTEEIQDPTLLKNRRKI
                     ERQGQAGTRTIQYEDYIVNGNVVETKEVSRTEVAPVNEVVKVGTLVKVKPTVEITNLT
                     KVENKKSITVSYNLIDTTSAYVSAKTQVFHGDKLVKEVDIENPAKEQVISGLDYYTPY
                     TVKTHLTYNLGENNEENTETSTQDFQLEYKKIEIKDIDSVELYGKENDRYRRYLSLSE
                     APTDTAKYFVKVKSDRFKEMYLPVKSITENTDGTYKVTVAVDQLVEEGTDGYKDDYTF
                     TVAKSKAEQPGVYTSFKQLVTAMQSNLSGVYTLASDMTADEVSLGDKQTSYLTGAFTG
                     SLIGSDGTKSYAIYDLKKPLFDTLNGATVRDLDIKTVSADSKENVAALAKAANSANIN
                     NVAVEGKISGAKSVAGLVASATNTVIENSSFTGKLIANHQDSNKNDTGGIVGNITGNS
                     SRVNKVRVDALISTNARNNNQTAGGIVGRLENGALISNSVATGEIRNGQGYSRVGGIV
                     GSTWQNGRVNNVVSNVDVGDGYVITGDQYAAADVKNASTSVDNRKADRFATKLSKDQI
                     DAKVADYGITVTLDDTGQDLKRNLREVDYTRLNKAEAERKVAYSNIEKLMPFYNKDLV
                     VHYGNKVATTDKLYTTELLDVVPMKDDEVVTDINNKKNSINKVMLHFKDNTVEYLDVT
                     FKENFINSQVIEYNVTGKEYIFTPEAFVSDYTAITNNVLSDLQNVTLNSEATKKVLGA
                     ANDAALDNLYLDRQFEEVKANIAEHLRKVLAMDKSINTTGDGVVEYVSEKIKNNKEAF
                     MLGLTYMNRWYDINYGKMNTKDLSTYKFDFNGNNETSTLDTIVALGNSGLDNLRASNT
                     VGLYANKLASVKGEDSVFDFVEAYRKLFLPNKTNNEWFKENTKAYIVEMKSDIAEVRE
                     KQESPTADRKYSLGVYDRISAPSWGHKSMLLPLLTLPEESVYISSNMSTLAFGSYERY
                     RDSVDGVILSGDALRTYVRNRVDIAAKRHRDHYDIWYNLLDSASKEKLFRSVIVYDGF
                     NVKDETGRTYWARLTDKNIGSIKEFFGPVGKWYEYNSSAGAYANGSLTHFVLDRLLDA
                     YGTSVYTHEMVHNSDSAIYFEGNGRREGLGAELYALGLLQSVDSVNSHILALNTLYKA
                     EKDDLNRLHTYNPVERFDSDEALQSYMHGSYDVMYTLDAMEAKAILAQNNDVKKKWFR
                     KIENYYVRDTRHNKDTHAGNKVRPLTDEEVANLTSLNSLIDNDIINRRSYDDNREYKR
                     NGYYTISMFSPVYAALSNSKGAPGDIMFRKIAYELLAEKGYHKGFLPYVSNQYGAEAF
                     ASGSKTFSSWHGRDVALVTDDLVFKKVFNGEYSSWADFKKAMFKQRIDKQDNLKPITI
                     QYELGNPNSTKEVTITTAAQMQQLINEAAAKDITNIDRATSHTPASWVHLLKQKIYNA
                     YLRTTDDFRNSIYK"
     gene            39708..40562
                     /locus_tag="ACL8AS_000923"
     CDS             39708..40562
                     /locus_tag="ACL8AS_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HGS1228804.1"
                     /translation="MTYEYQSHIYLAEAVLNVKDLVSQTVFYQQIIGLEILSQTDTEV
                     VLGLGGKALVHLIQAQEGGEVREHYGLYHLAILLPTRKALADVLKHLTDLQIPLVGGA
                     DHGYSEALYLEDLEGNGIELYRDKPVSTWDIREDGRIIGVTEVLAAQDIYELGERVEP
                     FILAEGTRMGHIHLSVKDSRKSRQFYQTVLGLEDKFSVPSASWIAAGDYHHHLAVNEW
                     GGKGLDPRKQVLPGLAYYVIEVAHKEELLTIAQRAQEVDAPIKWMTSIQLEITDSDGI
                     VTRIRLAR"
     gene            40668..41225
                     /locus_tag="ACL8AS_000924"
     CDS             40668..41225
                     /locus_tag="ACL8AS_000924"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HGS1228805.1"
                     /translation="MTSEYQKMIAGEFYRPSDPELRALAQASRQKQAAFNKEENPLKG
                     AEIIKTWFASTGKNLYINTRLMVDYGVNIHLGENFYSNWNLTMLDICPIRIGDNAMIG
                     PNCQFLTPLHPLDPQERNSGIEYGKPITIGDNFWTGGGVIVLPGVTLGNNVVAGAGAV
                     ITKSFGDNVVLAGNPARVIKEIPVK"
     gene            41442..42206
                     /locus_tag="ACL8AS_000925"
     CDS             41442..42206
                     /locus_tag="ACL8AS_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
                     /protein_id="HGS1228806.1"
                     /translation="MIQKHAIPILEFDDNPQAVIMPNHEGLDLQLPKKCVYAFLGEEI
                     DRYAREVGANCVGEFVSATKTYPVYVVNYKDEEICLVQAPVGSAPAAQFMDWLIGYGV
                     EQIISTGTCGVLADIEENAFLVPVRALRDEGASYHYVAPSRYMEMQPEAIAAIERVLD
                     DRGIPYEEVMTWSTDGFYRETAEKVAYRKEEDCAVVEMECSALAAVAQLRGVLWGELL
                     FTADSLADLDQYDSRDWGSEAFNKALELSLASVHHL"
     gene            42819..44198
                     /locus_tag="ACL8AS_000926"
     CDS             42819..44198
                     /locus_tag="ACL8AS_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000897732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015079 - potassium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HGS1228807.1"
                     /translation="MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQ
                     VESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWGQIICLLLIQIGGLGLMTFIGV
                     FYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQ
                     LGWGRGLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVW
                     FDLAGHVGRKKKGRLHFHTKLVLLLTIGLLLFGTATTLFLEWNNAGTIGNLPVADKVL
                     VSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLKITTFFVLLVF
                     ARSELLGLPHANVARRTIAPRTVQKSFSVFIIFLMSFLIGLILLGITAKGNPPFIHLI
                     FETISALSTVGVTANLTPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYHPEKKDMIH
                     YMKADISIG"
     gene            44212..44877
                     /locus_tag="ACL8AS_000927"
     CDS             44212..44877
                     /locus_tag="ACL8AS_000927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001283913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HGS1228808.1"
                     /translation="MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEP
                     VLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIAKVK
                     SQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWA
                     GQSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVA
                     LNS"
     gene            45012..45170
                     /locus_tag="ACL8AS_000928"
     CDS             45012..45170
                     /locus_tag="ACL8AS_000928"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228809.1"
                     /translation="MKIKDQTRKLATGCLKHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     NIYTARRC"
     gene            45232..45405
                     /locus_tag="ACL8AS_000929"
     CDS             45232..45405
                     /locus_tag="ACL8AS_000929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
                     /protein_id="HGS1228810.1"
                     /translation="MKLLSIAISSYNAAAYLHYCVESLVIGWDQVGNFSKGQYTMMHS
                     LIYRTDLLRASQF"
     gene            45472..45882
                     /locus_tag="ACL8AS_000930"
     CDS             45472..45882
                     /locus_tag="ACL8AS_000930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
                     /protein_id="HGS1228811.1"
                     /translation="MYYLPVDFYRYLIGREDQSVNEQVMIKCIDQQLKVNRLLVDQLD
                     LSQVSHPKMREYLLNHIEITTVISSTLLNRSGTAEHLAKKRQLWTYIQQKNPEVFQAI
                     RKTMLSRLTKHSVLPDRKLSNVVYQITKSVYGFN"
     gene            45998..>46885
                     /gene="pavB"
                     /locus_tag="ACL8AS_000931"
     CDS             45998..>46885
                     /gene="pavB"
                     /locus_tag="ACL8AS_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding SSURE repeat adhesin PavB"
                     /protein_id="HGS1228812.1"
                     /translation="MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADV
                     VNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKPEGVTGNTNSLPTPTERTEVSEET
                     NSSSLDTLFEKDEEAQKNPELTDVLKETVDTADVDGTQASPAETTPEQVKGGVKENTK
                     DSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAK
                     NPALPPLEGLTKGKYFYEVDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGK
                     ADLTNLVATKNVDININGLV"
BASE COUNT        13554 a         8808 c        10838 g        13685 t
ORIGIN      
        1 ggtattatca atcatgaact aggattctag ttttgcagga agtctaatag taaaaaagtg
       61 attagaaaac atctttttta aaaatagaga tgattttgaa acaaaaaagc taattcaaga
      121 cgtttcgatg ccaattcaag atttggatga aaaaaattaa tagatactgt tatactaaac
      181 ttgtcaagtt tgtaacaaga caaatattaa aaataaaaaa gaggtattcg ttatgaatac
      241 aaaaaagatg tcacaatttg aaattatgga tactgagatg cttgcttgcg ttgaaggtgg
      301 cggatgcaat tggggagatt ttgccaaagc aggtgttgga ggaggagcag tacgaggtct
      361 tcagctagga attaaaacaa gaacatggca aggtgcagca actggtgctg tgggaggagc
      421 tatacttgga ggtgtggcct atgcagcgac atgttggtgg taattatgga ttttaaaagt
      481 tttattattg gtttagtagt tggtatattt ggtccttata tggatgattt aattagaaaa
      541 aaatttttaa agtcttcgga gaagaaaaca gaaaaatctg ttaaaaaata atcaaaacta
      601 taaatgatga atctgaatca aaattatttt gcgcatgtaa ataggagtct tatagtaacg
      661 agtcaaaaaa ggagtaacta tgaatcgtaa tttagaacgg tgttatctat tctgactagg
      721 aatagatcat accagaggtg gcttagaaat agcggggaca ttagaaattg aagtaataaa
      781 taggatgtcg taagtgttac tatcaatgat ttatttgttt caagcttgcc tagggtgtca
      841 gtaaaaaatc attttccttt caatagcata tttttagtgg gcaggactct tgttctgcct
      901 atttttttat ccaaaaagtg cagttgggag ggagataggc tcatttggga aggaagtcca
      961 gtttttgttt agtgattggg gtaagatagt tgttatcaga tgagtttata ttcttcgaaa
     1021 atcaaattca aaccacgtca acgtcgcctt gccgtatata tgtgactgac ttcgtcagtc
     1081 ctatctacaa cctcaaaaca gtgttttgag cagcctgcgg ctagtttcct agtttgctct
     1141 ttgattttca ttgagtatta gggaaaagga gatgaatatg aaatttggga aacgtcacta
     1201 tcgtccgcaa gtggatcaga tggactgcgg tgtagcttca ttagccatgg tttttggcta
     1261 ctatggtagt tattattttt tggctcactt gcgagaattg gctaagacga ccatggatgg
     1321 aacgacggct ttgggcttgg tcaaggtggc agaggagatt ggttttgaga cgcgagccat
     1381 taaggcggat atgacgcttt ttgacttgcc ggatttgact tttccttttg ttgcccatgt
     1441 gcttaaggaa gggaaattgc tccactacta tgtggtgact gggcaggata aggatagcat
     1501 tcatattgcc gatccagatc ccggggtgaa gttgaccaaa ctgccacgtg atcgttttgc
     1561 ggaagaatgg acaggagtga ctctttttat ggcacctagt ccagactaca agcctcataa
     1621 ggaacaaaaa aatggtctgt tctcttttat ccctatatta gtgaagcagc gtggcttgat
     1681 tgccaatatc gttttggcaa cactcttggt aaccgtgatt aacattgtgg gttcttatta
     1741 tctgcagtct atcattgata cctatgtgcc agatcagatg cgttcgacac tagggattat
     1801 ttctattggg ctagtcatcg tctacatcct ccagcaaatc ttgtcttacg ctcaggagta
     1861 tctcttgctt gttttggggc aacgcttgtc gattgacgtg attttgtcct atatcaagca
     1921 tgtttttcac ctccctatgt ccttctttgc gacacgcagg acaggggaaa tcgtgtctcg
     1981 ttttacagat gctaacagta tcatcgatgc gctggcttcg accatccttt cgattttcct
     2041 agatgtgtca acggttgtca ttatttccct tgttctattt tcacaaaata ccaatctctt
     2101 tttcatgact ttattggcgc ttcctatcta cacagtgatt atctttgcct ttatgaagcc
     2161 gtttgaaaag atgaatcggg ataccatgga agccaatgcg gttctgtctt cttctatcat
     2221 tgaggacatc aacggtattg agactatcaa gtccttgacc agtgaaagtc agcgttacca
     2281 aaaaattgac aaggaatttg tggattatct gaagaaatcc tttacctata gtcgagcaga
     2341 gagtcagcaa aaggctctga aaaaggttgc ccatctcttg cttaatgtcg gcattctctg
     2401 gatgggggct gttctggtca tggatggcaa gatgagtttg gggcagttga ttacctataa
     2461 taccttgctg gtttacttta ccaatccttt ggaaaatatc atcaatctgc aaaccaagct
     2521 tcagacagcg caggttgcca ataaccgtct aaatgaagtg tatctagtag cttctgagtt
     2581 tgaggagaag aaaacagttg aggatttgag cttgatgaag ggagatatga ccttcaagca
     2641 ggttcattac aagtatggct atggtcgaga cgtcttgtcg gatatcaatt taaccgttcc
     2701 ccaagggtct aaggtggctt ttgtggggat ttcagggtca ggtaagacga ctttggccaa
     2761 gatgatggtt aatttttacg acccaagtca aggggagatt agtctgggta gtgtcaatct
     2821 caatcagatt gataaaaaag ccctgcgcca gtacataaac tatctgcctc aacagcccta
     2881 tgtctttaac ggaacgattt tggagaatct tcttttggga gccaaggagg ggacgacaca
     2941 ggaagatatc ttacgggcgg tcgaattggc agagattcga gaggatatcg agcgcatgcc
     3001 actgaattat cagacagaat tgacttcgga tggggcaggg atttcaggtg gtcaacgtca
     3061 gagaatcgct ttggcgcgtg ctctcttgac agatgcgccg gtcttgattt tggatgaggc
     3121 gactagcagt ttggatattt tgacagagaa gcggattgtc gataatctca tggctttgga
     3181 caagaccttg attttcattg ctcaccgctt gactattgct gagcggacag agaaggtggt
     3241 tgtcttggat cagggcaaga ttgtcgaaga aggaaagcat gctgatttgc ttgcacaggg
     3301 tggcttttac gcccatttgg tcaatagcta gaaagaggag aggatgaaac cagaattttt
     3361 agaaagtgcg gagttttata atcgtcgtta ccataatttt tccagtagtg tgattgtacc
     3421 catggccctt ctgctcgtgt ttttacttgg ctttgcaact gttgcagaaa aggagatgag
     3481 cttgtccact agagctactg tcgaacctag tcgtatcctt gcaaatatcc agtcaactag
     3541 caacaatcgt attcttgtca atcatttgga agaaaataag ctggttaaga agggggatct
     3601 tttggttcaa taccaagaag gggcagaggg tgtccaagcg gagtcctatg ccagtcagtt
     3661 ggacatgcta aaggatcaaa aaaagcaatt ggagtatctg caaaagagcc tgcaagaagg
     3721 ggagaaccac tttccagagg aggataagtt tggctaccaa gccacctttc gcgactacat
     3781 cagtcaagca ggcagtctta gggctagtac atcgcaacaa aatgagacca tcgcgtccca
     3841 gaatgcagca gctagccaaa cccaagccga aatcggcaac ctcatcaatc aaacagaggc
     3901 taaaattcgc gattaccaga cagctaagtc agctatggaa acaggtgctt ccttggccag
     3961 tcagaatcta gcctactctc tttaccagtc ctacaagtct cagggcgagg aaaatcccca
     4021 aactaaggtt caggcagttg cacaggttga agcacagatt tctcagttag aatctagtct
     4081 tgctacttac cgtgtccagt atgcaggttc aggtacccag caagcctatg cgtcagggtt
     4141 aagcagtcaa ttggaatccc ttaaatccca acacttggca aaggttggtc aggaattgac
     4201 ccttctagcc cagaaaatct tggaggcaga gtcaggtaag aaggtacagg gaaatctttt
     4261 agacaagggg aaaattacgg caagtgagga tggggtgctt catcttaatc ctgagaccag
     4321 tgattctagc atggttgcag aaggtgccct actagcccaa ctttatccat ctttggaaag
     4381 agaagggaaa gccaaactca cagcctatct aagttcaaaa gatgtagcaa gaatcaaggt
     4441 cggtgattct gttcgctata ctacgactca tgatgccggg aatcaacttt ttctagattc
     4501 tactattaca agtattgatg cgacagctac taagactgag aaagggaatt tctttaaaat
     4561 cgaggcggag actaatctaa cttcggagca ggctgaaaaa cttaggtacg gggtggaagg
     4621 ccgtctacag atgattacgg gcaagaaaag ttacctacgt tattatttgg atcaattttt
     4681 gaacaaagag taatgttcgt gtttttagag ttaaataatt tttaaactgt gagaaagatt
     4741 cttcttgcag ttttttcttt acaatttttg aaaaacatct gctatttatt cggttgaatt
     4801 cttgtgtttt ttggtttttt gtggtaaaat gtgctcaagt aatacgaaag gcgaacttta
     4861 aaatgtcaaa acaattgatc tattcgggaa aagctaaaga tatctataca actgaggatg
     4921 aaaatcttat tatttcaact tacaaggacc aggcgactgc tttcaacggt gtcaagaagg
     4981 agcagattgc aggtaaggga gtcttgaata atcagatttc atcttttatt tttgagaaat
     5041 taaatgcggc tggtgtggcg actcactttg tggagaaact ttcagacacg gaacaactca
     5101 ataaaaaggt taagattatt cctttggaag tcgtgctccg caactatact gctggttcct
     5161 tttcaaaacg ttttggtgtg gatgagggaa tcgccttgga gactccgatt gtcgaatttt
     5221 actacaaaaa tgatgatttg gatgatccat ttatcaatga tgagcatgtg aaattcctac
     5281 agattgcggg tgaccagcag attgcctact tgaaggaaga aacgcgtcgt atcaatgaac
     5341 tattgaaagt ctggtttgct gagattgggc ttaaattgat tgactttaag ctagagttcg
     5401 gttttgacaa ggatggcaag attatcttgg cagacgaatt ttcaccagat aactgccgct
     5461 tgtgggacgc tgatggcaac cacatggata aggatgtttt ccgtagagga ttgggagaac
     5521 taaccgacgt ttatgagatt gtttgggaaa agttgcaggg tttaaaataa caacctcaag
     5581 gctgtttggg aatattgcaa gagctgaaat aaaggaataa gaattgatgg ataaacgtat
     5641 ttttgttgaa aaaaaggctg attttcaggt caagtcagag agtttggtta gagagctcca
     5701 gcacaacgtg ggactgtcaa gcttgaaaag tattcgtatt gtgcaagtat atgatgtatt
     5761 tgacttggct gaggacttgt ttgcacctgc agagaagcac attttctctg agcagggaac
     5821 cgaccatgtt ttagatgaag tatctgtgca ggcggatctt gctaactatg ctttctttgc
     5881 cattgaaagt ctgccagggc agtttgacca gcgtgcagct tcgtcacagg aagccttgct
     5941 tttgttggga agttcgagtg acgtgacagt caacacagcc caactttact tggtgaataa
     6001 agatattgat gcgactgagt tggaagctgt caaaaactac ctgctcaatc cagttgattc
     6061 tcgtttcaag gatatcacga cagggattgc caagcaggag ttttcagagt cagacaagac
     6121 cattccaaaa ttgactttct ttgaaagcta tacagcagaa gactttgctc gctacaaggc
     6181 cgagcaaggg atggccatgg aagtggatga tttgctcttt atccaagact actttaagtc
     6241 aatcgggcgc gtgccaactg agactgaact caaggttttg gacacttact ggtctgacca
     6301 ctgccgtcat acgacttttg agacagagtt gaaacacatc gacttttcag cttctaaatt
     6361 tcaaaagcaa ttgcagtcaa cctatgacaa gtatattgcc atgcgcgagg agttaggtcg
     6421 gtctgaaaaa ccacaaacct tgatggatat ggcgactatt ttcggtcgtt atgagcgtgc
     6481 taacggacga ttggatgata tggaagtctc tgacgaaatc aatgcctgct cagttgaaat
     6541 tgaagtggat gttgatggtg tcaaggaacc ttggctcctc atgtttaaaa atgaaaccca
     6601 caaccatcca acagaaattg agccatttgg tggagcggct acctgtatcg gtggagctat
     6661 tcgtgatccg ttgtcaggcc gttcctatgt ttaccaagcc atgcgtattt caggtgctgg
     6721 tgatattaca gcaccgattt cggaaactcg tgctgggaaa ttgccacaac aagtcatttc
     6781 taaaacagca gctcatggtt attcttcata tggtaaccag attgggcttg ccacaaccta
     6841 cgttcgtgaa tacttccacc caggctttgt agctaaacgt atggaacttg gtgccgttgt
     6901 tggtgcggct cccaagggca atgttgtccg tgaaaaacct gaagcaggtg atgtgatcat
     6961 ccttctcgga ggcaaaacag gtcgtgatgg tgtcggtggt gcgacgggct cttctaaggt
     7021 tcaaacagtt gagtctgtag agactgctgg tgctgaggtt caaaaaggaa atgccatcga
     7081 agaacgcaag attcagcgcc tcttccgtaa tggcaatgtc actcgtctga tcaagaagtc
     7141 caatgacttt ggggcaggcg gcgtctgtgt ggctatcggt gaattggcag acggtcttga
     7201 aatcgacctc aacaaggtgc ctcttaaata ccagggcttg aatggtacag aaattgccat
     7261 ctctgaatca caagaacgga tggcggtcgt ggttcgtcct gaagatgtgg atgccttcgt
     7321 tgccgaatgt aacaaagaaa atattgatgc tgttgtggtg gcgatagtaa ctgaaaaacc
     7381 aaatcttgtc atgcactgga atggtgagac aatcgttgac ttggagcgtc gtttccttga
     7441 caccaatggt gtgcgcgtgg ttgtcgatgc caaagttgtg gacaaggatg tcaaactccc
     7501 agaagagcgt caaacatctg ctgaaacact ggaatcagat acccttacgg ttctatctga
     7561 cctcaaccat gcaagtcaaa aaggattaca gactatcttt gactgctctg ttggacgctc
     7621 aacggttaat cacccacttg gtggtcgtta ccaactcaca ccaactgagg catctgtgca
     7681 gaaattgcca gttcaacacg gtgtgactca tactgcgtcg gtcattgctc aaggtttcaa
     7741 cccatatgta gctgaatggt ctccatacca cggtgctgct tatgcggtta tcgaagcaac
     7801 tgctcgtttg gtggctgctg gtgccaactg gtccaaggct cgtttctctt accaagagta
     7861 tttcgagcgt atggataaac aagcagagcg tttcggtcag ccagtagctg ctcttctagg
     7921 ttctattgaa gcacaaattc agcttggctt gccatctatc ggtggtaagg actccatgtc
     7981 tggtaccttt gaagaattga ccgttccgcc aaccttggtt gcctttgggg tgacgacggc
     8041 agatagccgt aaggtgctct ctccagaatt taaagctgtt ggggaaaata tctactacat
     8101 cccaggtcaa gccctctctg cagagattga ttttgacttg attaagaaaa attttgctca
     8161 gtttgaagcc atccaagctg accataaagt gacatctgca tcagctgtca aatacggtgg
     8221 tgtagttgaa agtttggctc ttgctacctt tggaaactat attggtgcag aggtgacctt
     8281 gcctgaactt gaaacagctt tgacagctca attaggcggc tttgtcttca catctcctga
     8341 agaaattgct ggagtagaga aggttggaca aacgaaagca gactttacac tgactgtcaa
     8401 cggtgtgaag ctagatggac acaagcttga cagtgcattt caagggacat tggaagaagt
     8461 ttacccaaca gaatttaccc aagcgaaaga actagaagaa gtaccagctg tggcatcaga
     8521 tgttgtgatt aaagccaaag aaaaggttga aaaacctgtg gtttacatcc cagtctttcc
     8581 aggaaccaac tcagaatatg attcagctaa ggccttcgaa aaagaaggtg cagaggtcaa
     8641 tttggtgcca ttcgtgacct tgaatgaaga agctattgtc aagtcagttg aaactatggt
     8701 tgacaatatc gacaagacta atattctctt ctttgctggt ggattctcgg ctgcggatga
     8761 accagatggt tcagctaagt ttatcgtcaa tatcctgctt aatgaaaaag tgcgtgtggc
     8821 tattgatagc tttatcgccc gtggtggttt gattatcggt atttgtaatg gattccaagc
     8881 cttagtcaaa tcgggtctcc taccctacgg aaactttgaa gttgctaaca gtactagccc
     8941 aaccctcttc tacaatgatg ccaaccaaca cgtggccaag atggtggaaa ctcgcattgc
     9001 caataccaac tcaccatggt tggctggtgt gcaagtgggc gatatccacg ctattcctgt
     9061 ttcgcacggt gaagggaagt ttgtcgtgac ggctgaggaa tttgcagagc tccgtgacaa
     9121 tggacaaatt ttcagccaat acgttgactt taacggtaaa ccaagtatgg attctaagta
     9181 caatccgaat ggttctgtcc atgccatcga aggaattacc agcaagaatg gtcaaatcat
     9241 cggtaagatg ggccactcag aacgttatga ggacggtctt ttccaaaata tcccaggcaa
     9301 taaagaccag cacctgttcg cgtcagcggt taaacatttc actggaaaat aagacttaca
     9361 gattttctaa tagatagtat cagtaatgta aaagtcatgt aaatctagct cttgatgatt
     9421 acaaatgaaa attaggtata aaaaatgaca tacgaagtaa aatctcttaa tgaagaatgt
     9481 ggtgttttcg gtatttgggg acatccagat gctgctaagt tgacctattt tggactccac
     9541 agtcttcagc accgtggtca agagggggca ggaatcctct ccaatgacca aggaaaacta
     9601 aagcgccatc gtgacatggg acttttatca gaagtcttca gaaatcctgc taatttggat
     9661 aaattgacag ggactggtgc gattgggcat gtgcgttatg cgactgctgg cgaagcttct
     9721 gtagataaca tccagccctt cctcttccgt tttcacgata tgcagtttgg cttggctcat
     9781 aatgggaatc tgaccaatgc agcctctctc aagaaagaat tggaagatag aggagcaatt
     9841 ttcagtgcga cttcggattc ggaaatcttg gctcatctca ttcgtcgcag tcataatcct
     9901 agcctgatgg gcaaaatcaa ggaagcgctc agccttgtca aaggtggttt tgcctatatc
     9961 ttgctgtttg aggacaagtt gattgcggct cttgacccca atggtttccg tccgctttct
    10021 atcgggaaaa tggctaatgg agcagttgtt gtatcttctg aaacctgtgc ttttgaggtt
    10081 attggtgccg agtggattcg tgatttgaag ccaggtgaga ttgtgatcat tgatgacgag
    10141 ggcattcagt atgacagcta tacagatgat acccagttgg cgatttgttc tatggagtat
    10201 atctactttg ctcgccctga ttctaatatc cacggtgtca atgtccatac ggcacgtaag
    10261 agaatgggag cgcaattggc gcgagaattt aagcatgagg cagatattgt agttggtgtg
    10321 cccaattctt ccctaagcgc ggctatggga tttgcggaag aatcaggctt accaaatgaa
    10381 atgggtctga tcaaaaacca atacacccag cgaactttta tccaaccgac tcaagaattg
    10441 cgggagcaag gagtgcggat gaaactgtct gctgtttcgg gtgttgtcaa aggcaaacgt
    10501 gtggtcatgg tggatgattc cattgtacgt ggaacaacct ctcgtcgtat cgttcagctc
    10561 ttgaaagaag cgggtgcgac tgaggttcac gttgccattg gaagtcctgc actagcgtat
    10621 ccatgtttct acgggattga tatccagacc cgtcaggagc tgattgcagc caatcatacg
    10681 gtcgaagaaa ctcgccaaat cattggtgcg gacagtatga cttatctttc aattgatggc
    10741 ttgattgagt cgattggtat cgaaacagat gcgccgaacg gtggtctctg tgtcgcttac
    10801 tttgacggtg actacccaac gcctctctat gactacgaag aagactatcg tagaagtttg
    10861 gaagaaaaga ccagttttta caagtaggcg acagattctc cattaaagaa aaggaaaaaa
    10921 caaatgacaa ataaaaatgc atatgcccag tcgggtgtgg atgttgaagc gggttatgaa
    10981 gttgttgaac ggattaaaaa gcacgtggcc cgtacggagc gtgcaggtgt catgggagct
    11041 cttggtggct ttggtggtat gtttgacctt tccaagactg gggttaaaga acccgtcttg
    11101 atttcaggga ctgacggtgt cggaaccaag ctcatgttgg ctatcaagta cgacaagcac
    11161 gataccatcg ggcaggactg tgtggccatg tgtgtcaacg acatcattgc tgcaggtgcg
    11221 gaacccctct attttctcga ctacgtagcg acagggaaga atgaaccagc taagctagaa
    11281 caagtggttg ctggtgtggc agaaggttgt gtgcaggctg gtgctgccct catcggtggg
    11341 gaaacggctg aaatgccggg catgtacggc gaagacgact atgacttggc tggttttgcg
    11401 gtcggtgtgg ctgaaaaatc tcaaatcatt gacggttcaa aggtggtaga gggagatgtt
    11461 cttctcggac ttgtttcaag tgggattcac tcaaatggtt actctttggt tcgtcgtgtc
    11521 tttgcggatt acacaggtga ggaagtccta ccagaattgg aaggcaagaa acttaaggaa
    11581 gttctacttg agccgactcg tatctatgtc aaggctgtct tgccgctcat caaagaagag
    11641 ttggtcaacg gcattgccca catcacaggt ggtggcttta tcgaaaatgt ccctcgtatg
    11701 tttgcagatg acctagctgc tgaaattgat gaaagcaaag ttccagtgct tccaattttc
    11761 aaagcccttg aaaaatacgg tcagattaaa cacgaagaaa tgtttgaaat cttcaatatg
    11821 ggtgtgggac tcatgttggc ggtcagccct gaaaatgtag agcgtgtaaa agaattgttg
    11881 gatgaagcag tctatgaaat tggtcgcatc gtcaagaaag aaaacgaaag tgtcattatc
    11941 aaatgaaaaa aatagcggtt tttgcctctg gtaatggctc aaattttcag gtgattgccg
    12001 aagaatttcc agtggagttt gtcttttcag accatcgtga tgcctatgtg cttgagcgtg
    12061 caaagcagct cggcgttctg tcctatgctt ttgaactcaa ggagtttgag agcaaggcag
    12121 actacgaagc agcccttgtc gaactcttgg aagaacacca gattgacttg gtttgcctag
    12181 caggctacat gaaaatagtt ggaccaacct tattgtcggc ttatgaaggt cggattgtca
    12241 acattcatcc agcctacttg ccagaatttc caggagctca tgggattgag gatgcttgga
    12301 atgctggcgt gggtcagtct ggtgtgacca ttcactgggt ggattcgggt gtggatacag
    12361 gccaggtcat caaacaggtt cgtgtgccac gactagctga tgataccatt gacagatttg
    12421 aagctcgcat ccatgaagca gagtacaggt tgtatccgga agtagtgaag gctctattta
    12481 cagattgact ttttgatgat tcatatgata tctttgattt taaattggag tcagtgtttg
    12541 ttgaagacgg cttcaaacgg aggtatttgt aatgttagaa tctaaaaaaa caactcgata
    12601 tgtattttat gtctatctga tgttattaac ttggggaatc ttatttaagt ttgaaacaaa
    12661 tcctgaattt atagcatttt tcttagctcc aaggtatatc aattggattc cattttcaga
    12721 accactaata gtcgatggaa aaattgtttt tgctgaaatg ttatttaatc tgatttcctt
    12781 tattccatta ggtgtttgtt tccctttgat aaaaactaat ttatctagtt taagaatagt
    12841 cgggacaggt ttcttgatta gtttattgtt tgagtgctta cagtatattt tagcaatagg
    12901 tataacagat ataacggatt tgactttaaa tacgctaggt gtctgtgtag gcttactgat
    12961 ttatcaaatt tttataagag tgttcaaatc acagactaga aaatggatca atatcttagg
    13021 tatgcttagc cttggttttg cttatcttgt tttactgtta ctgcatttaa ttggtgttta
    13081 actaatgatt aaaaaggaga atataatgac taaacgcgtc ttaatcagcg tctcagacaa
    13141 agcgggcatt gttgaatttg cccaagaact caaaaaactt ggttgggaga ttatctcaac
    13201 aggtggaact aaggttgccc ttgataatgc tggggtggat accattgcta tcgatgatat
    13261 gactggtttc ccagaaatga tggacggtcg tgtgaagaca ctccacccaa atatccacgg
    13321 agggcttctc gctcgtcgtg acttggatag ccacttggaa gcggctaagg acaacaagat
    13381 tgagctcatt gaccttgtgg tggtcaacct ttacccattt aaggaaacta tccttaaacc
    13441 agatgtgact tatgctgatg cagttgaaaa tatcgatatt ggtgggccat ctatgcttcg
    13501 ttcagcagcg aaaaatcatg ccagtgttac agttgtggta gatcctgctg actacgctgt
    13561 ggttttggac gagttgtcag ccaatggtga aacgacttat gaaactcgcc aacgtttagc
    13621 agccaaagta tttcgtcaca cagcggctta tgacgccttg attgcagaat acttcacagc
    13681 tcaagtgggt gaaagcaagc ctgaaaagtt gaccttgact tatgacctca agcaagccat
    13741 gcgttacggt gagaaccctc aacaagacgc ggatttctac caaaaagcct tgccaacaga
    13801 ctactccatt gcttcagcca aacagctcaa tggtaaagaa ttgtccttca acaatatccg
    13861 tgatgcggat gctgccattc gtattattcg tgatttcaaa gaccgtccaa ctgttgtggc
    13921 tctcaaacac atgaacccat gtggaatcgg tcaggctgat aacattgaga ctgcttggga
    13981 ctacgcttat gagtctgacc cagtgtctat ctttggtggg attgtcgtcc tcaaccgtga
    14041 ggtggatgct gcgacagctg agaagatgca cggcgttttc ctcgaaatca tcattgcacc
    14101 aagctatacg gatgaagcgc tagctatttt gatcaataaa aagaaaaact tgcgtatcct
    14161 tgccttgcca tttaatgctc aagaggctag cgaagtggaa gcagaataca caggtgtagt
    14221 cggtggactt ctcgtgcaaa atcaagacgt ggtcaaggaa agcccagctg actggcaagt
    14281 ggtgaccaaa cgtcagccaa ctgagacaga agcgactgct cttgagttcg cttggaaggc
    14341 tatcaagtac gtcaaatcaa atggtattat cgtgaccaac gaccacatga cacttggtgt
    14401 tggtccaggt caaaccaacc gtgtggcttc tgttcgcctt gccattgacc aagccaaaga
    14461 tcgtctgaac ggggcggtcc ttgcttcaga tgccttcttc ccatttgcgg ataacgtgga
    14521 agaaatcgcc aaagcaggaa ttaaggccat catccagccc ggtggctctg tccgtgacca
    14581 agaatccatc gaagcagcgg ataaatacgg cttgactatg gtctttacag gtgtgagaca
    14641 ttttagacat taagaagata aaagggaaga aaacagtttc tttccttttt tggcttaaaa
    14701 tgctaactga aacaagatta aaacgaactt ttttgatata atattggtaa ataattcgca
    14761 aaagaggttg aggaatgaaa ctgcttgttg tcggttcggg tggtcgtgag catgcgattg
    14821 ctaaaaagtt acttgaatca aaagacgttg aaaaagtctt tgtagctcct gggaatgatg
    14881 ggatgactct ggatggtttg gaattggtaa atatctctat ttccgaacat tctaaattga
    14941 ttgacttcgc aaagaccaat gatgttgctt ggacctttat cggtccagat gatgcccttg
    15001 ctgctggtat cgtggatgat tttaaccaag ctgggcttaa ggcctttggt ccgactaggg
    15061 ctgcagcgga gctggagtgg tccaaggatt ttgccaagga aatcatggtc aaatatggtg
    15121 tttcgacagc agcctatggc acattttcag atttcgagga agcaaaggcc tatatcgaaa
    15181 agcatggtgc gcctatcgta gtcaaggcgg atggcttggc gcttgggaag ggtgtcgtcg
    15241 tttctgagac ggttgagcaa gcggtcgaag ccgctcatga gatgcttttg gacaataaat
    15301 ttggtgactc aggtgcgcgc gtggttattg aggaattcct tgaaggagag gaattttcac
    15361 tctttgcctt tgttaatggt gataagttct acatcatgcc aacggctcag gaccacaaac
    15421 gtgcctacga tggcgacaaa gggcctaaca cgggtggtat gggtgcctat gcgccagttc
    15481 cacacttacc acagagtgta gttgatacag cggttgacac cattgtcaag ccagttctag
    15541 aagggatgat taaagaaggt cgcccttatc tgggagttct ttacgcaggg cttatcctga
    15601 cagctgatgg accgaaagtc attgagttca acgctcggtt cggagatcca gaaactcaga
    15661 ttatcttgcc tcgcttgacc tctgactttg ctcaaaatat cacagatatc ctggatagca
    15721 aggagccaaa tatcatgtgg acggacaagg gtgtgactct gggtgtggtt gtcgcatcca
    15781 agggctaccc gctagactat gaaaggggcg ttgagttgcc agccaagaca gaaggcgatg
    15841 tcatcaccta ctatgcaggg gctaagtttg cggaaaatag cagagcactg ctctcaaacg
    15901 gcggacgagt ttatatgctc gttaccacag cagataccgt caaagaagcc caagccagca
    15961 tctaccaaga actataccaa caaaaaatag aaggactctt ctaccgaaca gatatcggaa
    16021 gcaaggcaat taagtaaaga tataagaata acgcgccgta gtcgccaaac acgataatgg
    16081 tcgtcgtggt gaaaagacca gaacagtgaa tgttctggtc agggggaaac ttggagaccg
    16141 taggctcaaa gtttaggaat gaaaccgaag gtttgcttcc gcctccatca cctaagacca
    16201 ttatcaaaaa gaaaaataaa aattcacaaa atacgttaat gatcgtatgg tttgcgagcg
    16261 ttagcgagct aatatagaac aatcaccgcc gttgtgaaag aacgattgga tgataatcca
    16321 atcgttcagg gaaattggaa gaccttgggt ttccaattta ggcatgagac acctttggtg
    16381 gctgctgccg tccctcacaa gctaaggtga ttgttgaaaa agaggaaaaa ggagaagaaa
    16441 tgaaaccagt aatttccatc atcatgggct caaaatccga ctgggcaacc atgcaaaaaa
    16501 cagcagaagt cctagaccgc ttcggtgtag cctacgaaaa gaaagttgtt tccgcacacc
    16561 gtacaccaga cctcatgttc aaacatgcag aagaagcccg tagtcgtggc atcaagatca
    16621 tcatcgcagg tgctggtggc gcagcgcatt tgccaggcat ggtagctgcc aaaacaaccc
    16681 ttccagtcat tggtgtgcca gtcaagtctc gtgctcttag tggagtggat tcactctatt
    16741 ctatcgttca gatgccgggt ggggtgcctg ttgcgaccat ggctatcggt gaagctggag
    16801 cgactaacgc agctctcttt gccctccgtc tcctctctgt agaagataag tccattgcgg
    16861 atgcacttgc caactttgct gaagaacaag gaaaaatcgc agaggagtcg tcaaatgagc
    16921 tcatctaaaa caatcggaat tatcggtggc ggtcaactgg gtcagatgat ggccatttct
    16981 gctatctaca tgggccacaa ggttatcgcg ctggatcctg cggcggattg cccggcctct
    17041 cgcgtggcgg aaatcattgt ggcaccttat aacgatgtgg atgccctccg tcagttggca
    17101 gaccgttgcg atgtcctcac ttatgagttt gaaaatgtcg acgctgacgg tttggatgcc
    17161 gttatcaagg atggacaact ccctcaagga acagatctgc tccgcatttc gcaaaatcgt
    17221 atttttgaaa aggacttttt gtcaaacaag gctcaagtca ctgtggcacc ctacaaggtc
    17281 gtgacttcta gcctagactt ggcagatatc gacttgtcga aaaactatgt cctcaagact
    17341 gcgactggtg gctacgatgg tcatggacaa aaggttattc gttcagaagc agacttggaa
    17401 gcagcctatg cgctagcaga ctcagcagac tgcgtcttgg aagaatttgt caactttgac
    17461 cttgagattt ctgtcatcgt gtcaggaaat ggcaaggagg tgacgttttt cccagttcag
    17521 gaaaatatcc accgcaacaa tatcctgtct aagaccatcg taccagcccg catttctgaa
    17581 agtctagtag acaaggctaa agctatggca gtgcgaatcg cagaacaact caacttgtct
    17641 ggaactctct gtgtggaaat gtttgcgact gatgatgacg ttattgtcaa tgaaatcgcc
    17701 ccacgaccac ataactctgg gcactattct attgaagcct gtgatttctc tcagtttgac
    17761 acccatattc tcggtgttct cggagcacca ttaccagtca tcaaactcca tgcgccagcc
    17821 gttatgctta atgtcctcgg tcagcatgtc gaggctgctg agcaatatgt gacagaaaat
    17881 tcaagcgccc acctccacat gtatggtaaa atagaagcga agcacaaccg caagatggga
    17941 catgtgacct tgtttagtga tgtaccggat agtgtggatg agcttgggga agggattgat
    18001 ttttaggaca agtctatgat acaaattatc gttaatacat ttattgaaaa ggataagact
    18061 ggagcagttg ttgaagtgtt gtatgccagt gctgaccaag ataaggtaca agctaaatat
    18121 gaagaactag ctgcacaata ccccgaaaat tatttagcta tctatgatgt accgctggat
    18181 acggatttga atacactaga tcattacccg tctgtgttta ttgaaaaaga ggagtttgag
    18241 tagaaatctt ggtttaccta gatagcttat tcccaacagc ttaagaagaa aggaaaaatt
    18301 aacacatgat caaccgttac tctcgccctg agatggcgaa tatttggagt gaagaaaata
    18361 aataccgtgc ttggcttgag gtggaaatcc tctctgacga ggcatgggct gagttggggg
    18421 aaatccctaa ggaagatgtg gctttgattc gcaagaaggc ggactttgac atcgaccgta
    18481 ttttggaaat tgagcaggag acgcgccacg atgtggtggc tttcacgcgt gcggtttctg
    18541 agactcttgg tgaagagcgc aagtgggttc actatgggtt aacttctacc gacgtggtgg
    18601 atactgctta tggttacctc tacaagcagg ccaacgacat catccgtcgt gaccttgaaa
    18661 acttcactaa tatcatcgct gacaaggcca aggagcacaa gttcaccatc atgatggggc
    18721 gtactcatgg tgtgcacgct gagccgacaa cctttggtct taaattggca acttggtaca
    18781 gcgaaatgaa acgcaatatc gagcgtttcg agcatgcagc tgctggtgta gaagctggta
    18841 agatttctgg tgcggttggg aactttgcca atatcccacc atttgtagag gagtatgtct
    18901 gcgataaact tggcatccgt gcccaagaaa tctctacaca agtccttcct cgtgaccttc
    18961 acgctgagta ctttgcggtt cttgccagca ttgcgacttc aatcgaacgt atggcgactg
    19021 agattcgtgg tctacaaaaa tctgagcaac gcgaagtaga agagttcttt gctaaagggc
    19081 aaaaagggtc ttcagcaatg cctcacaaac gcaacccaat cggttctgaa aatatgactg
    19141 gtctggcgcg tgtcattcgt ggtcacatga ttacggctta tgaaaacgtc gctctctggc
    19201 acgaacgcga tatttctcac tcatcagctg agcgtatcat cacaccagat acgaccattt
    19261 tgattgacta catgctcaac cgttttggaa atatcgtcaa gaacttgaca gtcttcccag
    19321 aaaatatgat ccgaaacatg aactcgactt ttggtcttat ctttagccaa cgggctatgt
    19381 tgacattgat tgaaaaaggc atgacccgtg agcaagccta tgacttggtg caaccaaaaa
    19441 cagcctactc ttgggacaac caagtagact ttaaaccact tcttgaggca gattcagaag
    19501 taacatcacg tctcactcaa gaagaaatcg atgaaatctt caacccagtt tattacacca
    19561 aacgagtgga tgatatcttt gaacgtcttg gactaggtga ttaattaaaa aataaacagc
    19621 gagcttcaat ctcgctgttt attttttatc gaaaagactt agtcttcttt tcttttagtg
    19681 agtccatagg ctgctagtgt ggacatgagt cctgcgacta ctagtcctgc agaatcgtga
    19741 gttcctgttt caggaagttt tttctctgtt accacaggag ctggatcttg aggaagagct
    19801 ttgctttcct cagcgggagc agttgatgga gctggttggc ttgggatttc tagttttggt
    19861 ttttcttcag caatagcggc ttgtccgttt tcatcgccta catgtgttac catagttccg
    19921 acttcgacta tttgagtaac ggcttcctgt gctacgacac tatttacaag tgttttcact
    19981 tccttaccat cggcagaagt gctcacagag tagaagttgc tacgatgtcc attgacgccc
    20041 ttagtaatga cttgtgtttt tcctttgagt aagagtggat tttcacgagt cactgtggta
    20101 aatggaattt cttctttttg gatatccagt ctaggtttta cctcagtagt tggtgcaaga
    20161 ccactttcat cacccttgtg agttacagga gcgccaactt caaccacttg gtttataact
    20221 tctttggtta cctggctatc aaggactgtt tctgttgttt ttccattttc agtgagtaca
    20281 gagatgtaat gagttcgttc acctttgact cctgctgtga taatattttc ctgaccagct
    20341 gggaggttag gattttcttt cttgataact tcaaatggaa tttcttcagt tcttgtgatg
    20401 agttctggtc tggtttcaac attggcagcc acttcatttt catccaggct tcctgaatga
    20461 gttgcagctg gtttgaggcc ttgaagagcg gcttttaggt tggctacaag tgtgtcaagc
    20521 tcagcttgtt tattacggtt gaggttgtaa tttagagctg ttttagctgc gtcaagggcc
    20581 tcaagacttt ctttactata tccttctaag tttgtaggaa ttttagctaa ttcttcgcgg
    20641 agagcattat aattagcacg gaagtagtct ttgttgtggt ctgcaaaggc agtcatgagt
    20701 tcaaagattt cctcttcctt gtactcagcg cttggtctat ctgcccagat tgaaagcata
    20761 cttccgactg ttggaagatc tacttcagga tatttggtag aagctagttg attgaatggt
    20821 gtttttccag tattctcaat agctttcttg aggaaaccac caccatcttc tggtttttga
    20881 ccaagaatgt agtaccagtc accgttggta ttcaagaatt tatagccttt gcttgctagg
    20941 tattgaggtg atgcgaggtt atatccccac cagcctttag accagtaaga aatcaagaca
    21001 tctttgtcaa actgaacatc gtccttgtct tcatagtaga agccatcgtt gaaggccatt
    21061 ggttgaagcc ctctttcttt ggccatagct gcgagggtgt tggcatattc ggcaaatttg
    21121 ccatagagtt gataccactt gaggtagtac cagccttggg cactagtcgc atcgttggcg
    21181 tattcgtcag taccaaagtt gaaaatcttt gttttacctg caaagaagtc catgtattta
    21241 ccgatgaggg cttttacaaa gttcatcgct tcttcgtttt tcaagtccat agttgttttt
    21301 gaaactttat caaagtgggc ttgaggattt ttaataccta atttttccat ggcaaccagc
    21361 atagcatcca tgtgacctgg actgttaata gctgggatga gaccgatgtc cttagattta
    21421 gcgtattcaa ttagctctgt tacttctgcc tgtgttagtg cagtaccgtt tggatcgtcg
    21481 tagtaagctt tagttccttc gataatagct tttttaacgt catcactagc ataggttttt
    21541 ccgttggcag taatggtcat atcatcgagt agaaagcgaa gtccgtcatt tcctagaagg
    21601 agatggacat cagaatatcc gagctcactg gccttgtcta cgatgcgttt gagctggttc
    21661 agagtaaagt atttgcgtcc agcatcgatt gagattacct tgtttttggc aagtttttca
    21721 acctcacgtt tagcttcttc ttcttttaga gcttcaggcg tgagggtcaa gttgttgaca
    21781 gtttcttgaa gtttagcaat ggcttgatca atcgtatctt gttgggcacg gctaaggttg
    21841 ctatcgagag agcgaatagc tttttcagct tcttttacgg ccgtgacgct ttctgcagta
    21901 taacggttca ggtcttttgg tacctcgtta agtgcttgct ctgcagattc ataatcagct
    21961 gcgaagtatt cagcgttggc atttgcaaaa tgacgcatga gtttgaagag gcgtgatggt
    22021 gaataacgtg cagatggagt gtcagcccaa gcagctacca taccaccgat gattgggata
    22081 tcagctcctt ctgtttttgg tacagaagtg attggtgtgt ttttaatacc attgagcccc
    22141 tgatcgagat tgtaccagcc ttggccatca gcgtttcgtc caagaacgta gtaccaagca
    22201 tcattggtat taaggatttg gtgacctttt tcagctagta gtttagaaga agcgacatcg
    22261 tagcctcccc aaccaccagt ccacatagaa acgatgatgt ctttgtcaaa actaccaaag
    22321 cttgtgtcgc tattgtagta gataccgtcg ttaaaagcca ttggtttgag accgtgcgat
    22381 tttacaatac gagcgaggtc attggcgtag gcaataaatt tttcatagcc ttttacaggg
    22441 tagccttcgt ttggatagta tttatcagct tgaagcacac tccaaccttt agcatctgtc
    22501 gcatcattgg catattcatc aagtccgatg ttgaagattt cagtcttttt cgcgaaataa
    22561 gcagcatact tgtcgataag ggcttttgta aaagcgacag cttgttcgtt gtcaagatcg
    22621 acagtacggg ctgatttctt cccaaaatag ctaaagttag ggttttggat tcccaattct
    22681 ttcatggcat tgagaatcgc atccatgtgt ccaggactat ttactgtcgg aatgagaccg
    22741 atacctttat ctttggcata gttaatcaga tctgtcattt gactttctgt taagtgattg
    22801 ccgtttggat cgttgtaata atcatttgta cctttttcaa tggcgcgttt gacatcgtca
    22861 ctggcatagg tcttgccgtt agctgtgatg ctcatatcgt ccaacatgaa acggagtcca
    22921 tcatttccga ctaataggtg taaatcagtg tagccataat gtttcgcttt atcgatgatt
    22981 tccttgagtt gttctggtga gaaatattta cgtccagcat caatagaaac aattttcttt
    23041 ttcgctagtt tttcatttac agttgcagca cgttcctttc ctgcctctgt ttccggtttg
    23101 tcagcctctg ctttcgcttc atctttttta gctggtttat ccttgtcagt cttgtctgta
    23161 tttgactctt tagaatcaac ctctttcgct tcttcctttt tagggctagc ttcttctgcc
    23221 tttttattag cagtttcttt ttcagcagaa gttggagtta ccacttctgc tttatcacta
    23281 ggagttgaac taacttcctc ttgtggtttt tcttctgttt ttggaagact agctacctta
    23341 tcagtagctg gagtttctgt ttctacagtt tttggagctt ctggttgaag cactgcttta
    23401 ggtgtttcct cagtccgatt ttcggatgat tgaggggaat cagaaaccgt atggatggtc
    23461 ggttggtttt ctgtagtagt aggagtaact ccatcggctg caacagtctg tgcttggaag
    23521 gcaaatccaa ttagaacaga agctgctcct acagcgtatt tacgaataga aaaacgctgt
    23581 tgtttttcat gtttcattgc aaaacctcct gattgcattg ttatattgat agcgattata
    23641 taaatcaacg cctttatttt atttcttata ttaacgagag tcaagaggag atgacaaaaa
    23701 actataataa gtataaaaaa atataaaatt taaacttaag atttcagatt ggtcggaaaa
    23761 aatacgtata tatatctagt ataatttttg gttctatttc tataaaatat tccacaaatt
    23821 atagaatttt ccaaaaatag gtaagcgcta cctttttggt gtggtataat aagcatagaa
    23881 aaagcccaag cgattagctc aggctttctt cttagtgatc acggtcacat gagataaatt
    23941 taatcttgta gtaatcagat cgtttgtaag tttcactgta ttctaaaact tggccagttg
    24001 attcgagttt ggtgatttta gtttgtagga cagtagggaa ttgttcatcg actccgagga
    24061 ctgaagccgc atgttctgga gttggaaaga ctatttcgtt gatttcttca aagtgttcat
    24121 cattcatgtg aatgtggtag tctaacttga aacgattata gatagaacta tagtattcaa
    24181 ggtttggata atttgcgttg atatattgtt ctgggatgta ggatgtatgg tagatataaa
    24241 cgacaccgtt tgattcgcgg atacgttcaa tcttgtagta gaattgatcg ccacgtagac
    24301 ccaatttttc caagtaaaca agcttgtttc cgcgttcaat tgaaagaaca gttaccttat
    24361 catctttagc attgaagagt tcaatatctg aaaactctac aagcttgtgt ttgcgtgcac
    24421 gtgaaacgaa ggttcctttt ccttgttggc ggacaatata gccatctttg gcaaggtcgt
    24481 ttaaggcgcg aacaactgtg atagagctga catcgtacat tgaaatgagt tctgcttcag
    24541 tgtaaaattt atctccactg ctaaactgcc cagagatgat tttatttttt aattcgtctt
    24601 ttatgtattg atatttggga attgccatat ttttacctct attttccttc tccatagaaa
    24661 attttaccat aaaagcgaaa aaaatagtag tcttttgaat aaaaaattag aataatagtc
    24721 tgaaaaatta agcgatatag ggattgctca tattttatca atgtattcta tacaaaatta
    24781 ttttaggtcc tatattccga atttaaagag cgtttgaaat gggtctaaaa atgtttgaaa
    24841 ctaattgaat gtgtgtataa tagtaaaaat gcagtaaata tcccgacaat ttctattgac
    24901 aattcaaaca gattggttta taattaatat aacaacaaat gaaagcgcaa actttcgcgg
    24961 tcggaaggta gttttatgac acgatttgag atacgagatg atttctatct cgatggaaaa
    25021 tcatttaaga ttttatctgg tgccattcat tattttaggg ttcctccaga ggattggtat
    25081 cattcgctct ataacttgaa ggctcttggt tttaatacgg tagagactta tgttgcttgg
    25141 aatttacacg agcctcgtga aggtgagttt cattttgaag gtgatctgga tttagagaaa
    25201 tttctccaaa tagcgcagga tttgggtctc tacgcaattg tgcgtccgtc tccatttatc
    25261 tgtgcggaat gggaattcgg tggcttacca gcttggctct tgaccaagaa catgcgaatt
    25321 cgctcatccg acccagcata tatcgaggca gttggtcgct actatgatca gttattgcca
    25381 agactggtgc ctcgtttgtt ggacaatggt ggcaatattc tcatgatgca ggttgaaaat
    25441 gagtatggtt cttacggaga agataaggct tacctgagag cgattcgaca gctaatggaa
    25501 gagtgtggcg taacctgtcc cctctttaca tcagatggtc catggcgagc tactctgaaa
    25561 gctggaacct taattgaaga ggacctcttt gtaacaggaa actttggttc taaggcacct
    25621 tacaactttt cgcagatgca ggaattcttt gatgaacatg gtaagaaatg gccactcatg
    25681 tgtatggagt tctgggatgg ttggttcaat cgctggaaag aaccgattat cacacgggat
    25741 cctaaggaat tggcagatgc agttcgagag gttttggaac aaggctctat caatctttac
    25801 atgttccacg gtggtacaaa ctttggtttc atgaatggtt gctcagctcg aggaactttg
    25861 gacctgccac aagttacgtc ttatgattac gatgcccttc tggatgaaga aggaaatcca
    25921 actgctaaat atcttgcagt caagaagatg atggcaacac atttttcaga gtatccgcag
    25981 ttggaaccac tctacaaaga gagtatggag ttggatgcta ttccactagt tgaaaaagtt
    26041 tctttgtttg aaaccttaga tagcttgtca agtcctgtag aaagtctcta tcctcaaaag
    26101 atggaggagc tgggacaaag ttatggctac ctactttatc gaacagaaac aaactgggat
    26161 gcagaagaag aaagacttcg tatcattgat ggtcgagata gggcccagct gtatgtcgat
    26221 ggtcagtggg ttaaaactca atatcagaca gagattgggg aagatatttt ttatcaaggt
    26281 aaaaagaaag ggctatctag gttagatatc ttgatagaaa atatggggcg tgtcaactat
    26341 gggcataagt tcttagcgga tacgcaacgt aagggaattc ggacaggggt ctgtaaggat
    26401 ctgcatttct tactaaactg gaaacactat ccactcccac tagacaatcc tgagaaaatt
    26461 gatttttcaa aaggatggac tcaaggacaa ccagcctttt acgcttatga ctttacagtc
    26521 gaagagccaa aagatactta cctagacttg tctgagtttg gtaagggggt tgcctttgtc
    26581 aatgggcaga atctaggacg tttttggaac gttggcccaa ctctctcact ttatatccct
    26641 catagctatc tcaaggaagg tgccaaccgc atcattatct ttgaaacaga aggtcaatat
    26701 aaagaagaga ttcatttaac tcgtaaacct acactaaaac atataaaggg ggaaaactta
    26761 tgacaattgt aggatgccgt attgatggac gtttgatcca cggacaagta gccaatcttt
    26821 gggctggaaa actaaatgtt tcacgcatta tggttgtaga cgacgaagtt gtcaacaacg
    26881 atattgaaaa gagtggtttg aaacttgcga caccaccagg tgtgaaattg agtattttgc
    26941 cagttgagaa agctgcagcc aatattcttg ctggcaaata cgatagccaa cgtctcttta
    27001 tcgtggctcg taaaccagac cgcttccttg gtttggtaga agcaggtgta ccacttgaaa
    27061 cccttaatgt tgggaatatg tctcaaacac cagaaactcg ttctattaca cgttctatca
    27121 acgtagtaga caaggatgtg gaagacttcc acaaactggc agaaaaaggt gttaaactta
    27181 ctgctcagat ggttccaaat gatccaattt cagacttttt gagcttatta aaataggaaa
    27241 aaaattttta ggaggtcatt gttatgatac aatggtggca aattttactt ctcactttgt
    27301 actcagctta tcaaatctgt gatgagttga cgatcgtttc atctgcaggt tcccctgtat
    27361 ttgctggttt cattactggt ttaatcatgg gagatgtgac tactggttta cttatcggtg
    27421 gtaacttgca actgttcgtt cttggggttg gtaccttcgg tggtgcttct cgtatcgacg
    27481 caacttctgg tgcggttctt gcgacagcct tctctgtttc acaaggaatt gatgcaccgc
    27541 ttgccattac tacaatcgct gtaccagtag cagctctctt gacttacttc gacgttcttg
    27601 gtcgtatgac tactaccttc ttcgctcacc gtgtggatgc tgcaatcgaa cgctttgact
    27661 ataaaggtat tgaacgcaac tacttgcttg gtgcgattcc gtgggctcta tctcgtgccc
    27721 ttccagtctt ctttgccctt gcttttggtg gtgcctttgt acaatcagta gtagacttcg
    27781 ttgaagccta caaatgggtt gcagatggct tgacacttgc aggacgtatg cttccaggtc
    27841 ttggatttgc aatcttgctt cgttaccttc cagttaaacg taaccttcac taccttgcta
    27901 tgggatttgg tttgacagct atgttgactg ttctttactc atatgtaaca ggtcttggtg
    27961 gcgctgttgc tggtatcgta ggtactcttc ctgctgaagt tgctgaaaaa attggtttcg
    28021 tgaacaactt caaaggtttg tctatgattg gtatttctat cgtaggtatt ttccttgcag
    28081 tgcttcactt caaaaatagc caaaaagtag ctgtagcagc accttctaca ccatcagaaa
    28141 gtggggaaat cgaagatgac gaattctaat tacaaactta caaaagaaga ttttaatcaa
    28201 atcaacaaac gtagcttgtt tactttccaa ttaggttgga actacgaacg tatgcaagct
    28261 tctggttacc tttacatgat cttgcctcag ttgcgtaaaa tgtatggtga tggaactcct
    28321 gaattgaaag aaatgatgaa agttcatact caattcttca atacttcacc attcttccat
    28381 accattatcg ctggttttga ccttgccatg gaagaaaaag atggtgtagg ttcaaaagac
    28441 gccgttaacg gtatcaagac aggtttgatg ggaccattcg ctcctcttgg ggatacaatc
    28501 tttggttcac ttgtacctgc tatcatgggg tcagtcgcag caactatggc tatcgctggc
    28561 caaccttggg ggatcttcct ttggattgca gttgcagtag cgtatgacat cttccgttgg
    28621 aaacagttgg aatttgctta caaagaaggg gttaacctta tcaacaacat gcaaagtacc
    28681 ttgacagctt tgattgacgc tgcatctgta cttggtgtct tcatgatggg tgctcttgta
    28741 gcaacagtga ttaactttga aatttcttac aagttgccaa tcggtgaaaa gatgattgat
    28801 ttccaagaca tcttgaacca aatcttccca cgtttgcttc cagcaatctt tactgccttt
    28861 atcttctggt tgcttggtaa gaaaggtatg aactctacta aagctatcgg tattattatc
    28921 gtacttgctt tggctctttc tgcccttggt cactttgcac ttggaatgta attccttatg
    28981 actaaatcat taattttggt gagccatggt cgcttctgtg aggagcttag aggtagcaca
    29041 gaaatgatta tgggcccaca agacaacatt tacacagtag ctcttcttcc agaagatggc
    29101 ccagaagaat ttactgctaa atttgaagct gttattgaag gattggatga tttcctagtc
    29161 tttgcggatc ttctcggtgg gacaccttgt aatgtggtga gtcgcttgat catggaaggt
    29221 cgtgatattg acctttacgc agggatgaat cttccaatgg tgattgaatt tatcaatgcg
    29281 agccttacag gcgcagatgc ggactacaag agccgtgctg cagaaagcat tgtgaaagtt
    29341 aatgacctgt tagcgggctt cgatgatgac gaagatgaat aatactcttc gaaaatctct
    29401 tcaaactacg tcaacgtcgc cttgccgtag gtatatgtta ctgacttcgt cagtcttatc
    29461 cggcaacctc aaaacggtgt tttgagctga cttcgtcagt cttatccggc aacctcaaag
    29521 cagtgctttg agcagcctgc ggctagtttc ctacagattt tagttggaac tcgattcaat
    29581 tcatgtgaca acgtgaaaat cgttagagca ttttatatag aatatacatg ggaatgtagc
    29641 ttactcccat tcccatattt aatagaaaaa gaggaactaa atgctacatt atacaaaaga
    29701 agacttgctc gaattgggtg cagaaatcac tacgcgtgaa atctaccaac agcctgatgt
    29761 atggagagaa gcttttgaat tttatcaagc aaaacgtgaa gaaattgcag ccttcctaca
    29821 agaaatcgct gataaacatg actatattaa ggttatcttg acaggtgctg ggacttctgc
    29881 ttatgtggga gataccttgc taccttattt taaggaagtc tatgacgaac gcaaatggaa
    29941 tttcaatgct attgcgacaa cagatatcgt tgccaatcca gcaacctatt tgaaaaaaga
    30001 tgtggcaact gtccttgtgt cttttgctcg tagtgggaat tcgcctgaaa gtttggcgac
    30061 tgttgatttg gccaaatcct tggtggatga gctttatcaa gtgacgatta cttgtgcagc
    30121 agatggtaaa ttggctcttc aagctcacgg tgatgatcgt aatctcttgc tcttgcaacc
    30181 agctgtctct aatgatgctg gatttgccat gacttctagc tttacgtcta tgatgttgac
    30241 aactctcttg gtctttgatc ctacagaatt tgctgttaag tctgaacgtt ttgaagttgt
    30301 atctagtctt gcccgtaaag ttttagacaa ggcagaagat gtcaaagagc tcgttgattt
    30361 agactttaac cgtgtcatct atctaggcgc tggtcctttc tttggacttg ctcatgaagc
    30421 tcagctcaag attttggaat taactgctgg tcaagttgcg accatgtatg aaagcccagt
    30481 tggcttccgt cacggtccaa aatctcttat caacgacaat acagttgttt tggtctttgg
    30541 tacaacgaca gactacactc gtaagtacga cttggacttg gttcgtgaag ttgctggtga
    30601 ccagattgct cgtcgtgttg tgcttttgag tgatcaagct tttggtcttg aaaatgtcaa
    30661 agaagtggcc cttggttgtg gcggtgtctt gaatgatatt taccgtgtct tcccttacat
    30721 cgtttatgcc caactctttg ctttattgac ttcactcaag gtagaaaata aaccagatac
    30781 accgtctcct acaggtacag taaaccgtgt agtacaaggt gtcataattc acgaatatca
    30841 aaagtaagac agtgtttatg aattcttgac aagaggattt gtaaattatc agataaacca
    30901 tagattgtca gtacgctttc tatggtttgt ttgcttgaga gaaatagtaa aaggagaaca
    30961 gaatgaaagc atacacagag cgtgtatttg gaaatgttga gggtgaggat gtcttggcct
    31021 atcgatttga gacagacggt ggctaccaac ttgaggttat gacttatggt gcgactatct
    31081 tgcgctatgt cgcacctgac aaggctggaa attttgccaa tgttatcttg ggatttgatg
    31141 actttgatag ttatgtaggc aatagtccca agcatggagc aagtgtaggt cctgtagcgg
    31201 gtcgtattgc aggtgcgacc tttgagctca atggtaagac ctatgacctt gaggttaata
    31261 atgctagcaa ctgtaatcac agtggttcaa ctggttggga ttccagcttg tttgaagttg
    31321 aagaagtaag cgatcatggc ttgactctct acacagagcg tacagatggg acaggagggt
    31381 tccctggaaa tctcaagatt tggatcagtt atcacttgga agaaactggt gcctatgaaa
    31441 tcagctacaa ggtaacgacc gatcaggata cgctggtcaa tccaaccaac cacagctatt
    31501 tcaacttgtc tggtgatttc acgcagacga ttgaccgtca tgtcttccaa ctaaacacag
    31561 agggcattta ctcaatcgct cctgacggtg ttcctgccaa aactccagaa gccaaccgtg
    31621 atgtggtcaa acacgtctac aatggtacct tgttgaagga tatctttgca gaagaagatg
    31681 agcaaatcca gctggcatca ggtttggatc atccatttgc ccttcctgca ggccatgaca
    31741 atgctggatt cctttatgac caaaattcag gtcgcttcct gcttttcaag acagaagctc
    31801 cttgctttgt ggtctacaca gcaaactttg tggatgaaag tgtcatcata ggaggtcagc
    31861 caatgctaca gcacaatggg attgctcttg aagcgcaagc tttaccagat gccattcaca
    31921 gtgaccttaa aggccaagtc attcttaaag ctggtcaaac cttcaccagt aagacacgtt
    31981 atgaacttgt tgtgaagtaa aagagtcatt gcgcctactt ttgggagcta ggaataggta
    32041 cgcagagaca aatagtagga aaatatgata taactaagcg ttgaaagcta tctgttaata
    32101 taatattcaa actacaataa ggagtaagaa agaaacgaag aaaattgtat ttgctagtgc
    32161 cttggctttg accttggctg gagcagtttt gacaaatgat gtttttgcga acgacagact
    32221 tgtggcaaca caaactactg atggtaaaaa tgaaaatgta ttgacctcag aggtgctaaa
    32281 accttctagt ggcaatgttt tggttggaat caaaggagaa tttgtggctc ctcatcaaca
    32341 atctattttg gatgccatca atgctatctg taaagaagcg gctgacgaag gtttggtaga
    32401 taagtatgtc cctatcaaat ggtcaactga cctagaaaag gcagcttttg ccagagctac
    32461 agaagcatct ataaccatgg atcatacccg tctttctagc aaagatcttt ggagtgcctt
    32521 tccaacttct aatagtataa tgggagaaaa tttggcatgg aatcatgacg gttttctaaa
    32581 agctattgaa caatggcgtg ctgaaaaagc agattatgtg gagacaaaaa tagtggttca
    32641 gacaacggga aatctggtca ctatgagtcg ctaattaacc ctaaatttac acacatgggg
    32701 atggcagctt ttaaaaatcc taacaatcaa tacaaagcta ttacaattgc tcaaactcta
    32761 ggtgatgatg cttcttcaga ggaattggct ggtagatatg gttctgctgt tcagtgtaca
    32821 gaagtgactg cctcaaacct ttcaacagtt aaaactaaag ctacggttgt agaaaaacca
    32881 ctgaaagatt ttagagcgtc tacgtctgat cagtctggtt gggtggaatc taatggtaaa
    32941 tggtatttct atgagtctgg tgatgtgaag acaggttggg tgaaaacaga tggtaaatgg
    33001 tactatttga atgacttagg tgtcatgcag actggatttg taaaattttc tggtagctgg
    33061 tattacttga gcaattcagg tgctatgttt acaggctggg gaacagatgg tagcagatgg
    33121 ttctactttg acggctcagg agctatgaag acaggctggt acaaggaaaa tggcacttgg
    33181 tattaccttg acgaagcagg tatcatgaag acaggttggt ttaaagtcgg accacactgg
    33241 tactatgcct acggttcagg agctttggct gtgagcacaa caacaccaga tggttaccgt
    33301 gtaaatggta atggtgaatg ggtaaactag gctcaggcca taggtaaagc attcatctta
    33361 cttagcaaaa agaatgaacg ataagaaaga ggttgatggc gaacattggc ctcttttgat
    33421 ttataaagat tggattcttg tcgcctcaat ttcagacttt tctattgtaa gctaatattt
    33481 tatagcccat taaaagcata agcggtaatc taatttaaaa aatgctgtaa ttagtctgaa
    33541 gtccacactt acttgttgag atgttatctc tgttttttat cgttataatt tactgtattt
    33601 tttatagtat gcagaatatt tttaagtata tttcaataga aatttctatc gatttattgt
    33661 ataatgataa gtaattgttg aaaagtactc agaaaattcc atactatatt atttttatgt
    33721 ttatactttt atgctataaa atatagattg atataaagaa tatagaaaaa gcgaggttaa
    33781 tatgagccga aaaagcattg gtgagaaacg ccatagtttc tcgatgagaa agttgtcagt
    33841 gggattggta tcagttactg tatctagttt ctttttgatg agtcaaggga ttcaatcggt
    33901 atcggccgat aatatggaaa gtccaattca ttataagtat atgaccgagg gtaaattgac
    33961 agacgaggaa aaatccttgc tggtagaggc ccttccacaa ctggctgaag aatcagatga
    34021 tacttattac ttggtttata gatctcaaca gtttttaccg aatacaggtt ttaacccaac
    34081 tgttggtact ttccttttta ctgcaggatt gagcttgtta gttttattgg tttctaaaag
    34141 ggaaaatgga aagaaacgac ttgttcattt tctgctgttg actagcatgg gagttcaatt
    34201 gttgccggcc agtgcttttg ggttgaccag ccagatttta tctgcctata atagtcagct
    34261 ttctatcgga gtcggggaac atttaccaga gcctctgaaa atcgaaggtt atcaatatat
    34321 tggttatatc aaaactaaga aacaggataa tacagagctt tcaaggacag ttgatgggaa
    34381 atactctgct caaagagata gtcaaccaaa ctctacaaaa acatcagatg tagttcattc
    34441 agctgattta gaatggaacc aaggacaggg gaaggttagt ttacaaggtg aagcatcagg
    34501 ggatgatgga ctttcagaaa aatcttctat agcagcagac aatctatctt ctaatgattc
    34561 attcgcaagt caagttgagc agaatccgga tcacaaagga gaatctgtag ttcgaccaac
    34621 agtgccagaa caaggaaatc ctgtgtctgc tacaacggtg cagagtgcgg aagaggaagt
    34681 attggcgacg acaaatgatc gaccagagta taaacttcca ttggaaacca aaggcacgca
    34741 agaacccggt catgagggtg aagccgcagt ccgtgaagac ttaccagtct acactaagcc
    34801 actagaaacc aaaggtacac aaggacccgg acatgaaggt gaagctgcag ttcgcgagga
    34861 agaaccagct tacacagaac cgttagcaac gaaaggcacg caagagccag gtcatgaggg
    34921 caaagctaca gtccgcgaag agactctaga gtacacggaa ccggtagcga caaaaggcac
    34981 acaagaaccc gaacatgagg gcgaagcggc agtagaagaa gaacttccgg ctttagaggt
    35041 cactacacga aatagaacgg aaatccagaa tattccttat acaacagaag aaattcagga
    35101 tccaacactt ctgaaaaatc gtcgtaagat tgaacgacaa gggcaagcag ggacacgtac
    35161 aattcaatat gaagactaca tcgtaaatgg taatgtcgta gaaactaaag aagtgtcacg
    35221 aactgaagta gctccggtca acgaagtcgt taaagtagga acacttgtga aagttaaacc
    35281 tacagtagaa attacaaact taacaaaagt tgagaacaaa aaatctataa ctgtaagtta
    35341 taacttaata gacactacct cagcatatgt ttctgcaaaa acgcaagttt tccatggaga
    35401 caagctagtt aaagaggtgg atatagaaaa tcctgccaaa gagcaagtaa tatcaggttt
    35461 agattactac acaccgtata cagttaaaac acacctaact tataatttgg gtgaaaataa
    35521 tgaggaaaat actgaaacat caactcaaga tttccaatta gagtataaga aaatagagat
    35581 taaagatatt gattcagtag aattatacgg taaagaaaat gatcgttatc gtagatattt
    35641 aagtctaagt gaagcgccga ctgatacggc taaatacttt gtaaaagtga aatcagatcg
    35701 cttcaaagaa atgtacctac ctgtaaaatc tattacagaa aatacggatg gaacgtataa
    35761 agtgacggta gccgttgatc aacttgtcga agaaggtaca gacggttaca aagatgatta
    35821 cacatttact gtagctaaat ctaaagcaga gcaaccagga gtttacacat cctttaaaca
    35881 gctggtaaca gccatgcaaa gcaatctgtc tggtgtctat acattggctt cagatatgac
    35941 cgcagatgag gtgagcttag gcgataagca gacaagttat ctcacaggtg catttacagg
    36001 gagcttgatc ggttctgatg gaacaaaatc gtatgccatt tatgatttga aaaaaccatt
    36061 atttgataca ttaaatggtg ctacagttag agatttggat attaaaactg tttctgctga
    36121 tagtaaagaa aatgtcgcag cgctggcgaa ggcagcgaat agcgcgaata ttaataatgt
    36181 tgcagtagaa ggaaaaatct caggtgcgaa atctgttgcg ggattagtag cgagcgcaac
    36241 aaatacagtg atagaaaaca gctcgtttac agggaaactt atcgcaaatc accaggacag
    36301 taataaaaat gatactggag gaatagtagg taatataaca ggaaatagtt cgagagttaa
    36361 taaagttagg gtagatgcct taatctctac taatgcacgc aataataacc aaacagctgg
    36421 agggatagta ggtagattag aaaatggtgc attgatatct aattcggttg ctactggaga
    36481 aatacgaaat ggtcaaggat attctagagt cggaggaata gtaggatcta cgtggcaaaa
    36541 cggtcgagta aataatgttg tgagtaacgt agatgttgga gatggttatg ttatcaccgg
    36601 tgatcaatac gcagcagcag atgtgaaaaa tgcaagtaca tcagttgata atagaaaagc
    36661 agacagattc gctacaaaat tatcaaaaga ccaaatagac gcgaaagttg ctgattatgg
    36721 aatcacagta actcttgatg atactgggca agatttaaaa cgtaatctaa gagaagttga
    36781 ttatacaaga ctaaataaag cagaagctga aagaaaagta gcttatagca acatagaaaa
    36841 actgatgcca ttctacaata aagacctagt agttcactat ggtaacaaag tagcgacaac
    36901 agataaactt tacactacag aattgttaga tgttgtgccg atgaaagatg atgaagtagt
    36961 aacggatatt aataataaga aaaattcaat aaataaagtt atgttacatt tcaaagataa
    37021 tacagtagaa tacctagatg taacattcaa agaaaacttc ataaacagtc aagtaatcga
    37081 atacaatgtt acaggaaaag aatatatatt cacaccagaa gcatttgttt cagactatac
    37141 agcgataacg aataacgtac taagcgactt gcaaaatgta acacttaact cagaagctac
    37201 taaaaaagta ctaggagcag cgaatgatgc agccttagat aacctatact tagatagaca
    37261 atttgaagaa gttaaagcta atatagcaga acacctaaga aaagtattag cgatggataa
    37321 atcaatcaat actacaggag acggtgtagt tgaatacgta agtgagaaaa tcaaaaataa
    37381 caaagaagca tttatgctag gtcttactta tatgaaccgt tggtacgata ttaattatgg
    37441 taaaatgaat acaaaagatt tatctacgta caagtttgac tttaacggaa ataatgagac
    37501 ttcaacgttg gatactattg tcgcattagg aaatagtgga ctagataacc tgagagcttc
    37561 aaatactgta ggtttatatg cgaataaact tgcatcggta aaaggagaag attcagtctt
    37621 tgacttcgta gaagcgtata gaaaactgtt cttaccaaac aaaacaaata acgagtggtt
    37681 taaagaaaat acaaaggcat atatagtcga aatgaagtct gatattgcag aagtacgaga
    37741 aaaacaagaa tcaccaacag ccgatagaaa atattcatta ggagtttacg atagaatatc
    37801 agcaccaagt tgggggcata agagtatgtt attaccacta ctaactttac ctgaagaatc
    37861 tgtgtatatt tcatcgaata tgtctacact tgcattcggt tcgtatgaaa gatatcgtga
    37921 tagtgtggat ggagttattc tttcaggaga tgctttacga acttatgtaa gaaatagagt
    37981 tgatatagca gcgaaaaggc atagagacca ttatgatatt tggtacaatc ttcttgacag
    38041 tgcttcaaaa gaaaaacttt tccgttctgt gatagtttat gatggattca atgtaaaaga
    38101 tgagacagga agaacttatt gggcaaggtt aacggataaa aacatcggct ctattaaaga
    38161 attcttcgga cctgttggga aatggtatga gtataatagt agtgcaggag cgtatgcgaa
    38221 tggaagttta acgcactttg tgttagatag attattagat gcttatggaa cgtcggttta
    38281 tactcatgaa atggttcata attctgattc tgcaatctac tttgaaggaa atggtagacg
    38341 tgaaggattg ggagcggagt tatacgcact tggtttactg caatctgtag atagtgtaaa
    38401 ttctcatatt ttagctttaa atacgttata taaagcagaa aaagatgatt tgaatagatt
    38461 gcatacatat aatccggtgg aacgtttcga ttcggatgag gcgcttcaaa gttatatgca
    38521 tggatcatat gatgtaatgt atacacttga tgcgatggaa gcaaaagcga tattagctca
    38581 aaataatgat gttaagaaaa aatggtttag aaaaatagaa aattattacg ttcgtgatac
    38641 tagacataat aaagatacac atgcaggaaa taaagtccgt ccattaacag atgaagaagt
    38701 agctaactta acatcgttaa actcattaat cgacaacgac atcataaata gacgtagcta
    38761 tgatgataat agagaatata aacgaaatgg ctactatact ataagtatgt tctctcctgt
    38821 atacgcagcg ctaagcaatt cgaaaggtgc tcctggagat attatgttta gaaaaatagc
    38881 ttatgaatta cttgcggaaa aaggttatca caaaggattc ctaccttatg tttctaatca
    38941 gtacggagca gaagcatttg ccagcggaag caaaacattc tcatcatggc atggaagaga
    39001 tgttgcttta gtgacagatg atttagtatt taagaaagta ttcaatggtg agtactcatc
    39061 atgggctgat ttcaaaaaag caatgtttaa acaacgtata gataaacaag ataatctgaa
    39121 accaataaca attcaatacg aattaggtaa tcctaatagt acaaaagaag taactataac
    39181 aacggctgca caaatgcaac aattaattaa tgaagcggct gcgaaagata ttactaatat
    39241 agatcgtgca acgagtcata ccccagcaag ttgggtgcat ttattaaaac aaaaaatcta
    39301 taatgcatat cttcgcacta cagatgactt tagaaattct atatataaat aagattgtag
    39361 agtttcattg ttgagtagtg tttcttgtaa ggatgaggag tcagatgaca aatcgactcc
    39421 tttttcttat ggatcgatgt agagatttga ttgaatgcag attgcaggaa tcatcttcaa
    39481 ctcatcaacg accaatggtg acaaggtgga tttcaatccc acagaaaatg ttgatttgag
    39541 aaataacttt gctagtctag taaaataaat acaaaacaat cctagaagat tttttctggg
    39601 attgtttttt gctgagtggg atgcttcaag ttgtctggct tgactttctt gagggaagtt
    39661 atataatagt tgtaataatt aaagttacaa taaaagagga aatatttatg acatatgaat
    39721 accagagcca catttattta gcagaggcag ttttaaatgt gaaggatttg gtcagtcaaa
    39781 cagtttttta tcagcagatt attggtttag aaatcctatc tcaaacggat acagaggtcg
    39841 ttctgggact tggaggaaaa gccttggtac acttgattca agcacaagag ggtggagaag
    39901 taagggaaca ttatggtctt taccatctgg ctattctttt gccgacacga aaggctttgg
    39961 cggatgtctt gaagcacctg acggatttac agattcctct tgttggcggt gcagatcacg
    40021 gttacagtga ggccctttac ttagaggact tggagggaaa tggcattgaa ctctatcgag
    40081 ataagccagt ttccacatgg gatattcgag aagatggacg tattatcggg gtgactgaag
    40141 tccttgcggc tcaggatatc tatgagttgg gggaaagagt agagcctttt atcctagcag
    40201 agggtacgag aatggggcat attcatcttt ctgtcaagga tagtcgaaag tccagacagt
    40261 tttatcaaac ggtgttaggg ctcgaggata aattcagtgt gcctagtgct agttggatcg
    40321 cagctgggga ctaccatcat catttagcag tcaacgaatg gggaggaaaa ggtctggatc
    40381 cgcgtaaaca agtcctacca ggtttagcct actatgtcat cgaagtcgca cataaagaag
    40441 aactgttaac gattgcccaa cgagcacaag aagttgacgc accaatcaaa tggatgacat
    40501 cgatccaatt ggaaatcaca gactcagatg gcatcgtgac ccgtattcgt ttagctagat
    40561 agatggtatg tgatgaaggt agagcatcaa ttgtagaaag tgctccttat tctagtcaga
    40621 tacgtggaaa atttgatatg atagtaggga ataaggagaa gaataatatg actagcgaat
    40681 accagaaaat gatagcagga gagttttacc gtccatcaga cccagaactg agagccttag
    40741 ctcaggcttc tcgccaaaaa caggccgcct ttaacaagga agagaacccc ttgaagggag
    40801 ccgaaatcat caagacttgg tttgcctcaa ccgggaaaaa tctttacatc aacactcgct
    40861 tgatggtgga ctacggtgtc aacatccatc taggggaaaa tttttattct aattggaact
    40921 tgaccatgct ggatatctgt cccattcgta tcggggacaa tgctatgatt ggtcctaatt
    40981 gtcagttttt gacacccctc catccactag atccacagga acgcaattca ggtatcgagt
    41041 acggaaagcc tatcacaatc ggagataatt tctggactgg tggtggcgtc attgtccttc
    41101 ctggagtgac actgggaaat aatgtcgttg caggagcagg ggcagtaatt accaaatctt
    41161 ttggcgacaa cgttgtccta gctggcaatc ctgcgcgcgt gattaaggaa atacctgtta
    41221 aatagaagta aaaaggaaca gctggggttg tttctttttt gtaggtttca tcatttttta
    41281 cccagttcac atttacctac tctatctctt agcaagtctg tttcattaag caagttcaaa
    41341 gcatctcgta agtgggatgt ttttctcctc agttcatcag cttcctcctt gacactcggt
    41401 cagattttga tacaatagta caaaattaga ggaggcaggc tatgattcag aaacatgcga
    41461 ttcctatttt agagtttgat gacaatcctc aggcggttat catgcccaat cacgaggggc
    41521 tggacttgca gttgccaaag aagtgtgttt atgcattttt aggtgaggag attgaccgct
    41581 atgcgaggga agtaggggcg aactgtgttg gcgaatttgt ttctgccacc aagacctatc
    41641 cagtttatgt cgtgaactac aaggacgagg agatttgtct ggttcaggct cctgtcggtt
    41701 cagctccagc agcccagttt atggattggt tgattggcta tggtgtggag cagattatct
    41761 ctactgggac ctgtggtgtc ctagctgata tagaggaaaa tgcctttcta gtccctgttc
    41821 gcgctctgcg agatgaagga gccagttacc actatgtggc accttctcgt tatatggaaa
    41881 tgcagccaga ggctattgct gccattgagc gagttttgga tgatagaggg attccttatg
    41941 aagaagtcat gacctggtcc acagatggtt tttaccgaga aacggctgaa aaggtggctt
    42001 atcgcaagga agaagactgt gctgttgtgg agatggagtg ttccgctctt gcggcagtag
    42061 ctcaattgcg tggggttctc tggggtgaat tgttgttcac agcagattct ctagcggact
    42121 tggaccagta cgacagtcgt gactggggct cggaagcttt taataaggcg ctagaactga
    42181 gtttagcaag tgttcaccac ctttagttgt actggcaaag gatttgtttt atcataaaat
    42241 gtctagctca tacttttcaa aaatatgttt aaacgaggtc accttcctct tgtcctaggc
    42301 atgttgaggt tgggaaaaat ctttaaaatc agaaaaacgt atcatatcag gtgatgaaaa
    42361 ctttgacact atgcgtttta tgtcgataag atttagagtg agatgaaatg atactcttcg
    42421 aaaatctctt caaaccaggt cagcttcacc ttgccgtagg tatatgttac tgacttcgtc
    42481 agtcttatcc ggcaacctca aaacggtgtt ttgagctgac ttcgtcagtt ctatttgcaa
    42541 cctcaaaaca gtgttttgag caacctgtga ctagctttct aatcgatgcc ttggttttca
    42601 ttgcctataa tcaaaaagag aaattttctc ctgaaaagca tatagagtag ctggcgttaa
    42661 aagctcctgt cttgcttttt tgacctatag tcacatctat caagtattgt tcttgcctaa
    42721 gctatcaata aaaaggtggc attttttagg cttggtgtta gtagattttg ccttatccta
    42781 tctaagtcat ttcgaacttt ttatggtaca atggaaacat gttattcaaa ttatctaagg
    42841 aaaaaataga gctaggctta tctcgtttat cgccagcccg tcgtattttt ttgagttttg
    42901 ccttggtcat tttactaggc tctcttcttt tgagcttgcc ctttgtccaa gttgaaagct
    42961 cacgagcgac ttattttgat catcttttca ctgctgtctc tgcagtctgt gtgacgggtc
    43021 tctcaaccct tccagtagct cacacctata atatctgggg tcaaataatc tgtttgctct
    43081 tgattcagat cggtggtcta gggctcatga cctttattgg ggttttctat atccagagca
    43141 agcaaaagct tagtcttcgt agccgtgcaa ctattcagga tagttttagt tatggagaaa
    43201 ctcgatcttt gagaaagttt gtctattcta tttttctcac gacctttttg gttgagagct
    43261 tgggagctat tttgcttagt tttcgcctta ttcctcaact tggctgggga cgtggtcttt
    43321 ttagttccat ttttctagcg atctcagcct tctgtaatgc cggttttgat aatttaggga
    43381 gcaccagttt atttgctttt cagaccgatt tactggtcaa tctggtgatt gcaggcttaa
    43441 ttattacagg cggccttggt tttatggtct ggtttgattt ggctggtcat gtaggaagaa
    43501 agaaaaaagg acgtctgcac tttcatacga agcttgtact attgttgact ataggtttgt
    43561 tgttatttgg aacggcaact actctctttc ttgagtggaa caatgctgga acgattggca
    43621 atctccctgt tgccgataag gttttagtta gcttttttca aacagtgacg atgcgaacag
    43681 ctggcttttc tacgatagat tatactcagg ctcatcctgt gactcttttg atttatatct
    43741 tacagatgtt tctaggtggg gcacctggag gaacagctgg gggactcaag attacgacat
    43801 tttttgtcct cttggtcttt gcacgaagtg agcttctagg cttgcctcat gccaatgttg
    43861 cgagacgaac gattgcgccg cgaacggttc aaaaatcctt tagtgtcttt attatctttt
    43921 tgatgagctt cttaatagga ttgattctgc tagggataac agccaaaggc aatcctccct
    43981 ttatccacct catatttgaa accatttcag ctcttagtac agttggtgta acggcaaatc
    44041 tgactcctga ccttgggaaa ttggctctca gtgttatcat gccacttatg tttatgggac
    44101 gaattggtcc cttgaccttg tttgttagct tggcagatta ccatccagaa aagaaagata
    44161 tgattcacta tatgaaagca gatattagta ttggttaaga aaggaaagag catgtcagat
    44221 cgtacgattg gaattttggg cttgggaatt tttgggagca gtgtcctagc tgccctagcc
    44281 aagcaggata tgaatattat cgctattgat gaccacgcag agcgcatcaa tcagtttgag
    44341 ccagttttgg cgcgtggagt gattggtgac atcacagatg aagaattatt gagatcagca
    44401 gggattgata cctgcgatac cgttgtagtc gcgacaggtg aaaatctgga gtcgagtgtg
    44461 cttgcggtta tgcactgtaa gagtttgggg gtaccgactg ttattgctaa ggtcaaaagt
    44521 cagaccgcta agaaagtgct agaaaagatt ggagctgact cggttatctc gccagagtat
    44581 gaaatggggc agtctctagc acagaccatt cttttccata atagtgttga tgtctttcag
    44641 ttggataaaa atgtgtctat cgtggagatg aaaattcctc agtcttgggc aggtcaaagt
    44701 ctgagtaaat tagacctccg tggcaaatac aatctgaata ttttgggttt ccgagagcag
    44761 gaaaattccc cattggatgt tgaatttgga ccagatgacc tcttgaaagc agatacctat
    44821 attttggcag tcatcaacaa ccagtatttg gataccctag tagcattgaa ttcgtaaaga
    44881 gggatgaccc ctcttttttg atgcccaaga tggcaaatag agacagaagc cccttgtctt
    44941 ctagtaaaag ttcttcaaag gctggacttt atggtaaaat agaaggaagt gacaagagag
    45001 agtaatactc aatgaaaatc aaagatcaaa ctaggaaact agctacgggc tgcttaaaac
    45061 actgttttga ggttgtggat agaactgacg aagtcagctc aaaacactgt tttgaggttg
    45121 cagatagaac tgacgaagtc agtaacatct atacggcaag gcgatgttga cgcggtttga
    45181 agagattttc gaagagtata agaaaaaatc agtcccctaa aggagcagat tatgaagtta
    45241 ttgtctatcg ccatttctag ctataatgca gcagcctatc ttcattactg tgtggagtcg
    45301 ctagtgattg gctgggacca ggtcggaaat ttctccaaag gccagtatac catgatgcac
    45361 tcgctgattt atcggacaga tttgttgcgt gctagccagt tctaactgcc tgaacatact
    45421 ttttatgtcg ataatctctt tgtctttacg ccccttcagc aggtcaagac catgtactat
    45481 ctgcctgtcg atttctatcg ttatttgatt gggcgtgagg accagtctgt caatgagcaa
    45541 gtgatgatta agtgcattga ccagcaactc aaggtcaatc gactcttggt agaccaactt
    45601 gatttgtccc aagtgagtca tcccaaaatg cgagaatatc tgctgaatca tattgaaatc
    45661 acgacggtga tttccagtac cctgctcaac cgatctggaa cagcggagca tctggcaaaa
    45721 aaacgccaat tgtggaccta tattcagcag aaaaatccag aagtctttca ggctattcgt
    45781 aagaccatgt tgagccgttt gaccaaacat tctgtcttgc cagatcgcaa actgtccaat
    45841 gtcgtctatc aaatcaccaa atctgtttat ggatttaatt aatataagtg ttttataaga
    45901 gggatttaag aaaaatttta actttttctt agtccttttt aatttcagga gattatacta
    45961 gagtcatcaa ataaagaaag actctaagga gaatcctatg aaattcaatc caaatcaaag
    46021 atatactcgt tggtctattc gccgtctcag tgtcggtgtt gcttcagttg ttgtggctag
    46081 tggcttcttt gtcctagttg gtcagccaag ttctgtacgt gccgatgtgg tcaatccgac
    46141 cccaggtcaa gtcttacctg aagagacatc gggaacgaaa gagggtgact tatcagaaaa
    46201 accaggagac accgttctca ctcaagcgaa acctgagggc gttactggaa atacgaattc
    46261 acttccgaca cctacagaaa gaactgaagt gagcgaggaa acaaactctt ctagtctgga
    46321 tacacttttt gaaaaagatg aagaagctca aaaaaatcca gagctaacag atgtcttaaa
    46381 agaaactgta gatacagctg atgtggatgg gacacaagca agtccagcag aaactactcc
    46441 tgaacaagta aaaggtggag tgaaagaaaa tacaaaagac agcatcgatg ttcctgctgc
    46501 ttatcttgaa aaagctgaag ggaaaggtcc tttcactgcc ggtgtaaacc aagtaattcc
    46561 ttatgaacta ttcgctggtg atggtatgtt aactcgtcta ttactaaaag cttcggataa
    46621 tgctccttgg tctgacaatg gtactgctaa aaatcctgct ttacctcctc ttgaaggatt
    46681 aacaaaaggg aaatacttct atgaagtaga cttaaatggc aatactgttg gtaaacaagg
    46741 tcaagcttta attgatcaac ttcgcgctaa tggtactcaa acttataaag ctactgttaa
    46801 agtttacgga aataaagacg gtaaagctga cttgactaat ctagttgcta ctaaaaatgt
    46861 agacatcaac atcaatggat tagtt
//
LOCUS       DBERMM010000013        44833 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.013, whole genome shotgun sequence.
ACCESSION   DBERMM010000013 DBERMM010000000
VERSION     DBERMM010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 44833)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44833)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44833
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.013"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(1..783)
                     /locus_tag="ACL8AS_000932"
                     /pseudo
     CDS             complement(1..783)
                     /locus_tag="ACL8AS_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            992..2749
                     /locus_tag="ACL8AS_000933"
     CDS             992..2749
                     /locus_tag="ACL8AS_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannitol-specific transporter subunit IIBC"
                     /protein_id="HGS1228813.1"
                     /translation="MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGY
                     LPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGAVVGAIATVGAITGSSVPMFIGA
                     MVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLT
                     GAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFL
                     LEANPGPGLGILLAYAVFGKGSAKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAM
                     AGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHLNVLLGVLVAAVVSFLVA
                     ALILHADKSTEDSLEAAQAATQAAKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAM
                     GASILRDKVKKAGLEIPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDN
                     FLASPRYDEIVASLTGAFPIAEIEGDIPTSAPVDSQEIDLNHIDAVVVAYGKAQGTAT
                     MGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQQAAPNSQFLI
                     VDSLVTTPEYDKMAARMYK"
     gene            2773..4728
                     /locus_tag="ACL8AS_000934"
     CDS             2773..4728
                     /locus_tag="ACL8AS_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HGS1228814.1"
                     /translation="MLLTKREEQLLKAFLHVGKLSMQDMTEILQVSSRTIYRTLSDLT
                     DSMEQYGIEITKHGKYYILTGELDDLPTELEVLVEYSPQERQELITYRLLTESGFVTN
                     EALQECTKVSNVTIIQDISDIDKRLLDFDLKIERQKGYRISGDSVGKRRFLAILLTNC
                     ISVADFSTGNFGSFDILEADRTRLASQIVNKQLSGFPDMDARMKMFFAILLSLIGQEQ
                     NIENSPNTSKQALEISQKIFQTYSKQTAQFYSIQEIIYFASILDELIIKRQDNPLFTE
                     KFDGEFFYNISNLIDTVSMYTKIDFFKDKVLFNFLFHHIRLSLGVPILFQGENLPESV
                     QILVERNKFLYTVISLLVNDIFPKYLHTEYEYGMIALHFISSLGRSPEIYPVRVLLLT
                     DERRVTRDLLVSKIKSVAPFVELIDIQSLVDYHSIDLSQYDYILSTKPLTNQEIGVIS
                     SFPTVKELLELQERLQYVQAHRTIVARDAIAPEKSYDLQDYLISSSQLLSQFELVQLE
                     NNQSFEHTVEQIIQYQKNVSDRDYLTRKLLSHFQNSPMAIPNTGLVLLHSQSSKVTTN
                     SFTMFELKLPISALSMKREEEEVKRCLLMLMSKEASEEARDLMTAISQSIIENHLYTE
                     IYKTGNQSIIYQMLNTIFNEKIKKLEN"
     gene            4730..5167
                     /locus_tag="ACL8AS_000935"
     CDS             4730..5167
                     /locus_tag="ACL8AS_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HGS1228815.1"
                     /translation="MKLEKHLIKLNKQFSNKEEAICYCGQVLYEGGYVNEDYIEAMIE
                     RDKELSVYMGNFIAIPHGTDAAKNDVLKSGITVVQVPRGVDFGNVSNPQVATVLFGIA
                     GIGNEHLEIIQKISIFCADVDNVLKLADAQSKEEVLRLFDAVE"
     gene            5229..6365
                     /locus_tag="ACL8AS_000936"
     CDS             5229..6365
                     /locus_tag="ACL8AS_000936"
                     /EC_number="1.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HGS1228816.1"
                     /translation="MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEK
                     GKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELL
                     AKGIEARRVAGNTQVLDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
                     DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVN
                     SGHATSAYIGAHYGAKTILEALQNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHK
                     VIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSLSYKNLLKTVGYAFD
                     YRDVNDEESIRLGELLAKQSVKDVVIQVTGLDDQELIEQIVEYI"
     gene            7151..8434
                     /gene="tig"
                     /locus_tag="ACL8AS_000937"
     CDS             7151..8434
                     /gene="tig"
                     /locus_tag="ACL8AS_000937"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005854 - nascent polypeptide-associated
                     complex [Evidence IEA];
                     GO_function: GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA];
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0015031 - protein transport [Evidence IEA];
                     GO_process: GO:0051083 - 'de novo' cotranslational protein
                     folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HGS1228817.1"
                     /translation="MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGF
                     RKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQ
                     DWVIAAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAA
                     ENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVT
                     FPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKEL
                     AAAKEEAYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDM
                     YFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYN
                     MEVAQVQSLLSADMLKHDITIKKAVELITSTATVK"
     gene            complement(8482..10848)
                     /locus_tag="ACL8AS_000938"
     CDS             complement(8482..10848)
                     /locus_tag="ACL8AS_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0043139 - 5'-3' DNA helicase activity
                     [Evidence IEA];
                     GO_process: GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HGS1228818.1"
                     /translation="MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVT
                     GTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLK
                     TAQKIVDTYGENTIDEILQHPEKLEGIAGLSAKNREAFVSTLRLNYGTEMVLAKLANY
                     GIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERF
                     RAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDK
                     VQQIDTKIFDNSLFFAEEGIRSHLVRILEKGEQKSHHLETIQKHITTIEQELGIEYDN
                     IQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDLRKKSNLPILLAAPT
                     GRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDADFIIVDEFSMVDTWLANQL
                     FSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSKESTIVTLA
                     SQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGAALRNGIPARDIQVLAPMYR
                     GTAGIDAINQLMQDLLNPPQKDQLSFEAPQCHYRKRDKVIHLVNDAEINVFNGDLGAI
                     TDLIPGKYTESKQDEIVIDFDGNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPI
                     TSASRRMLERNLIYTAITRAKSKLILLGELQAFDHAIQHIGTARKTYLIERFSDLLEN
                     VEEKQQAVSETVTSSASEQSYILTEENWNRIPAMIGITDTDLKEIFGK"
     gene            complement(11127..11741)
                     /gene="lepB"
                     /locus_tag="ACL8AS_000939"
     CDS             complement(11127..11741)
                     /gene="lepB"
                     /locus_tag="ACL8AS_000939"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006465 - signal peptide processing
                     [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HGS1228819.1"
                     /translation="MNSFKNFLKEWGLFLLILSLLALSRIFFWSNVRVEGHSMDPTLA
                     DGEILFVVKHLPIDRFDIVVAHEEDGNKDIVKRVIGMPGDTIRYENDKLYINDKETDE
                     PYLADYIKRFKDDKLQSTYSGKGFEGNKGTFFRSIAQKAQAFTVDVNYNTNFSFTVPE
                     GEYLLLGDDRLVSSDSRHVGTFKAKDITGEAKFRLWPITRIGTF"
     gene            complement(11745..12626)
                     /gene="rnhC"
                     /locus_tag="ACL8AS_000940"
     CDS             complement(11745..12626)
                     /gene="rnhC"
                     /locus_tag="ACL8AS_000940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA];
                     GO_process: GO:0006401 - RNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HIII"
                     /protein_id="HGS1228820.1"
                     /translation="MASITLTPSEKDIQAFLEHYQTSLAPSKNPYIRYFLKLPQATVS
                     IYTSGKILLQGEGAEKYASFFGYQAVEQTSGQNLPLIGTDEVGNGSYFGGLAVVAAFV
                     TPDQHDFLRKLGVGDSKTLTDQKIRQIAPILKEKIQHQALLLSPSKYNEVIGDRYNAV
                     SVKVALHNQAIYLLLQKGVQPEKIVIDAFTSAKNYDKYLAQETNRFSNPISLEEKAEG
                     KYLAVAVSSVIARDLFLENLENLGRELGYQLPSGAGTASDKVASQILQAYGMQGLSFC
                     AKLHFKNTEKAKKRLER"
     gene            12713..13015
                     /gene="zapA"
                     /locus_tag="ACL8AS_000941"
     CDS             12713..13015
                     /gene="zapA"
                     /locus_tag="ACL8AS_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HGS1228821.1"
                     /translation="MANLNRFKFTFGKKSLTLTSEHDNLFMEEIAKVATEKYQAIKEQ
                     MPSADDETIALLLAVNCLSTQLSREIEFDDKEQELEELRHKLVTCKQEQSKIEDSL"
     gene            13012..13560
                     /locus_tag="ACL8AS_000942"
     CDS             13012..13560
                     /locus_tag="ACL8AS_000942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CvpA family protein"
                     /protein_id="HGS1228822.1"
                     /translation="MISFLLLLVLVWGFYIGYRRGLLLQVYYLISAMASAFMAGQFYK
                     GLGEQFHLLLPYANSQEDQGTFFFPSDQLFQLDKVFYAGIGYLLVFGIVYSIGRLLGL
                     LLHLIPSQKLGGKLFQVSAGILSMLVTLFVLQMALTILATIPMAVIQNPLEKSIVAKH
                     IIQSIPITTSWLKQIWVTNLIG"
     gene            13664..16000
                     /locus_tag="ACL8AS_000943"
     CDS             13664..16000
                     /locus_tag="ACL8AS_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HGS1228823.1"
                     /translation="MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIK
                     QAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLASREL
                     QSFYANLENVSLEELAFWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
                     SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTV
                     YIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRA
                     KVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVHFGQDLTAIVITGPNTGGK
                     TIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNI
                     VDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYG
                     IETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQD
                     NDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKARE
                     QAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAK
                     KKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPV
                     KKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTG
                     VIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG"
     regulatory      16163..16251
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            16342..17664
                     /locus_tag="ACL8AS_000944"
     CDS             16342..17664
                     /locus_tag="ACL8AS_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005283 - amino acid:sodium symporter
                     activity [Evidence IEA];
                     GO_function: GO:0015293 - symporter activity [Evidence
                     IEA];
                     GO_process: GO:0006814 - sodium ion transport [Evidence
                     IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alanine/glycine:cation symporter family protein"
                     /protein_id="HGS1228824.1"
                     /translation="MLELLKSIDDFAWGPPLLILLVGTGVYLTMRLGLLQVLRLPKAF
                     QLIFIQDKGHGDVSSFAALCTALASTVGTGNIIGVATAIKVGGPGALFWMWMAAFFGM
                     ATKYAEGLLAIKYRTKDDHGAVAGGPMHYILLGMGEKWRPLAVLFAVAGVLVALLGIG
                     TFTQVNSITESIQNTTTISPAITALVLSVFVAIAVFGGLKSISKVSTTVVPFMAIIYI
                     LGTLTVIFFNIGKIPGTIALVFTSAFSPLAAVGGFAGASVRMAIQNGVARGVFSNESG
                     LGSAPIAAAAAKTNEPVEQGLISMTGTFIDTLIICTLTGLTILVTGVWSGDLNGVALT
                     QSAFSTVFSHFGPALLTIFLVLFAFTTILGWNYYGERCFEFLFGVRFIWLYRVVFVLM
                     VLLGGFIELDMVWIIADIVNALMALPNLIALLVLSPVVIAETKKYFDK"
     gene            17882..18430
                     /locus_tag="ACL8AS_000945"
     CDS             17882..18430
                     /locus_tag="ACL8AS_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000206764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HGS1228825.1"
                     /translation="MTTFTIHTVESAPAEVKEILETVEKDNNGYIPNLIGLLANAPTV
                     LEAYQIVSSIHRRNSLTPVEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMNDDLIQA
                     LRNRTPIETDPKLDTLAKFTLAVINTKGRVGDEALSEFLEAGYTQQNALDVVFGVSLA
                     ILCNYANNLANTPINPELQPYA"
     gene            18540..19439
                     /locus_tag="ACL8AS_000946"
     CDS             18540..19439
                     /locus_tag="ACL8AS_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000735961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HGS1228826.1"
                     /translation="MKKLPLVFSGCLLGLAGAGNLILDTLPVLSHLFSLTGLVLWIYF
                     LILHLFNWKETKQELTKPPLLSGMATFPMAGMILSTYVFRVFSYLPLVAQGIWWFSFL
                     LDLTLIAGFTIKFACPGRRVHATPSWTVLYVGIAVAALTYPLVGIIEIAYATLSFGFL
                     LTFYLYPLIYSDLKKHPLPLALLGQEGIYCAPFSLLLASLVRVGGTSLPTWVLIVMIL
                     ASQSFFFFVLTRLPNILKQGFQPAFSALTFPTIITATSLKMAQGILKLPFLDYLVLAE
                     TIICLTILFFVLGAYLIWLRKKV"
     gene            complement(19464..20738)
                     /gene="serS"
                     /locus_tag="ACL8AS_000947"
     CDS             complement(19464..20738)
                     /gene="serS"
                     /locus_tag="ACL8AS_000947"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004828 - serine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006434 - seryl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HGS1228827.1"
                     /translation="MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILIK
                     VETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTT
                     TLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
                     ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTF
                     ELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIR
                     LHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSATKTY
                     DLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTV
                     AAILENYQNEDGSVTIPEALRPYMGGAEVIKP"
     gene            complement(20952..21323)
                     /locus_tag="ACL8AS_000948"
     CDS             complement(20952..21323)
                     /locus_tag="ACL8AS_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HGS1228828.1"
                     /translation="MAQSLNKTVLLSTTGTSYLSIAGKVGKFLVGDQALEFYPDVNVE
                     QFIQIPWSHINQIGANVTGRKISRHFEVFTDKGKFLFASKDSGAILKIARKKLGNDKV
                     VKLPTLIQTISQKFKNLFAKK"
     gene            complement(21326..22690)
                     /locus_tag="ACL8AS_000949"
     CDS             complement(21326..22690)
                     /locus_tag="ACL8AS_000949"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004072 - aspartate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HGS1228829.1"
                     /translation="MKVVKFGGSSLASASQLEKVLNIVKSDSERRFVVVSAPGKRNAE
                     DTKVTDALIKYYRDYVAGNDISKSQSWIIDRYAAMVSELGLKPAVLEKISKSIHALAT
                     LPIEENEFLYDTFLAAGENNNAKLIAAYFNQNGIDARYMHPREAGIVVTSEPGHARII
                     PSSYDKIEELTNTNEVLVIPGFFGVTKENQICTFSRGGSDITGSIIAAGVKADLYENF
                     TDVDGIFAAHPGIIHQPHSIPELTYREMRELAYAGFSVLHDEALLPAYRGKIPLVIKN
                     TNNPDHPGTRIVLKHSNDEFPVVGIAGDSGFVSINMSKYLMNREVGFGRKVLQILEEL
                     NIGWEHMPTGIDDLSIILRSRQLTPIKEEEILRQLVQKAKVDHAEIEHDLSIIMIVGE
                     KMKSHIGVTATATRALSENKINIQMMSQGSSEVSIMFVVNKDQEKAAIKALYNAFFGE
                     SKED"
     gene            23059..23844
                     /locus_tag="ACL8AS_000950"
     CDS             23059..23844
                     /locus_tag="ACL8AS_000950"
                     /EC_number="4.2.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase"
                     /protein_id="HGS1228830.1"
                     /translation="MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEEN
                     PAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVL
                     MEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAA
                     QLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWES
                     QFKDWQGYATLELNLQKSLAQTEDFKEGVRAHSERRRPKFTGK"
     gene            23938..24372
                     /locus_tag="ACL8AS_000951"
     CDS             23938..24372
                     /locus_tag="ACL8AS_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="HGS1228831.1"
                     /translation="MDYQRINEYLTSIFNNVLVIEEVNLRGSRFKDISIKEMHTIDVI
                     GKAPDVTPSQVSKELMVTLGTVTTSLNNLERKGYIERVRSEQDRRVVHLHLTKKGRLI
                     HRLHKRFHKAMVEKIIDGMSEEEIAVMGKGLTNLYQFLEDLK"
     gene            24372..25346
                     /locus_tag="ACL8AS_000952"
     CDS             24372..25346
                     /locus_tag="ACL8AS_000952"
                     /EC_number="2.3.1.180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="HGS1228832.1"
                     /translation="MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRH
                     ISRTESTSDLATEVAKKLMAKAGITGKELDFIILATITPDSMMPSTAARVQANIGANK
                     AFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
                     AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVF
                     DFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMME
                     YGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI"
     gene            25406..25630
                     /locus_tag="ACL8AS_000953"
     CDS             25406..25630
                     /locus_tag="ACL8AS_000953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002938891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000035 - acyl binding [Evidence IEA];
                     GO_function: GO:0000036 - acyl carrier activity [Evidence
                     IEA];
                     GO_process: GO:0009245 - lipid A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HGS1228833.1"
                     /translation="MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISE
                     IEDAFDIQIEAENDLKTVGDLVAYVEEQAK"
     gene            25749..26723
                     /gene="fabK"
                     /locus_tag="ACL8AS_000954"
     CDS             25749..26723
                     /gene="fabK"
                     /locus_tag="ACL8AS_000954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0018580 - nitronate monooxygenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HGS1228834.1"
                     /translation="MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGG
                     NAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKY
                     MERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATA
                     ISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDT
                     TISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVD
                     GGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWAGVVRND"
     gene            26716..27636
                     /gene="fabD"
                     /locus_tag="ACL8AS_000955"
     CDS             26716..27636
                     /gene="fabD"
                     /locus_tag="ACL8AS_000955"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HGS1228835.1"
                     /translation="MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDL
                     RYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGA
                     LDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
                     TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTALLEPASQKLAETLAQVS
                     FSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGK
                     VLSGFVKKIDQTAHLAHVEDQASLVALLEK"
     gene            27670..28401
                     /gene="fabG"
                     /locus_tag="ACL8AS_000956"
     CDS             27670..28401
                     /gene="fabG"
                     /locus_tag="ACL8AS_000956"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004316 - 3-oxoacyl-[acyl-carrier-protein]
                     reductase (NADPH) activity [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HGS1228836.1"
                     /translation="MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEEL
                     LAEFSNYGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKMTE
                     ADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQANYAASKAGL
                     IGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKEATLAQIPMKEFGQAEQVA
                     DLTVFLAGQDYLTGQVVAIDGGLSM"
     gene            28423..29658
                     /gene="fabF"
                     /locus_tag="ACL8AS_000957"
     CDS             28423..29658
                     /gene="fabF"
                     /locus_tag="ACL8AS_000957"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HGS1228837.1"
                     /translation="MKLNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHS
                     DFDVHNAAEIQDFPFDKYFVKKDTNRFDNYSLYALYAAQEAVNHANLDVEALNRDRFG
                     VIVASGIGGIKEIEDQVLRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSI
                     NTACSSSNDAIGDAFRSIKFGFQDVMLVGGTEASITPFAIAGFQALTALSTTEDPTRA
                     SIPFDKDRNGFVMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEG
                     QGAIKAIKLALEEAEISPEQVAYVNAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSF
                     TGHLLGAAGAVEAIVTIEAMRHNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISN
                     TFGFGGHNAVLAFKRWENR"
     gene            29661..30146
                     /gene="accB"
                     /locus_tag="ACL8AS_000958"
     CDS             29661..30146
                     /gene="accB"
                     /locus_tag="ACL8AS_000958"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001052236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA];
                     GO_function: GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HGS1228838.1"
                     /translation="MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVA
                     TQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVASEGNLVESPLVGVVYLAAGP
                     DKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRI
                     K"
     gene            30143..30565
                     /gene="fabZ"
                     /locus_tag="ACL8AS_000959"
     CDS             30143..30565
                     /gene="fabZ"
                     /locus_tag="ACL8AS_000959"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA];
                     GO_function: GO:0019171 -
                     (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HGS1228839.1"
                     /translation="MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFF
                     NGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQL
                     VMTATFVKRRGTIAVVEAKAEVDGKLAASGILTFAIGN"
     gene            30577..31944
                     /gene="accC"
                     /locus_tag="ACL8AS_000960"
     CDS             30577..31944
                     /gene="accC"
                     /locus_tag="ACL8AS_000960"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000488661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA];
                     GO_function: GO:0004075 - biotin carboxylase activity
                     [Evidence IEA];
                     GO_function: GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HGS1228840.1"
                     /translation="MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLL
                     ADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKF
                     IGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
                     AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEH
                     GHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEF
                     LLDEASSNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGH
                     AIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKII
                     VHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPK
                     YQEKE"
     gene            31981..32847
                     /gene="accD"
                     /locus_tag="ACL8AS_000961"
     CDS             31981..32847
                     /gene="accD"
                     /locus_tag="ACL8AS_000961"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001173351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA];
                     GO_function: GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase, carboxyltransferase
                     subunit beta"
                     /protein_id="HGS1228841.1"
                     /translation="MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTI
                     YQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLA
                     SMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKL
                     PVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAM
                     EGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTI
                     ASLVRLHGGSPR"
     gene            32844..33611
                     /locus_tag="ACL8AS_000962"
     CDS             32844..33611
                     /locus_tag="ACL8AS_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyl transferase
                     subunit alpha"
                     /protein_id="HGS1228842.1"
                     /translation="MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAV
                     VGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVT
                     FINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRV
                     WMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEIGLSS
                     KELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY"
     gene            33770..33955
                     /gene="briC"
                     /locus_tag="ACL8AS_000963"
     CDS             33770..33955
                     /gene="briC"
                     /locus_tag="ACL8AS_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biofilm-regulating peptide BriC"
                     /protein_id="HGS1228843.1"
                     /translation="MTGTNTFTVLSTEDLEQTSGGLAVWEDGYSRWLYYREFAPYMRQ
                     GALNSYIDAWKYGFRAG"
     gene            33973..34446
                     /locus_tag="ACL8AS_000964"
     CDS             33973..34446
                     /locus_tag="ACL8AS_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228844.1"
                     /translation="MRNTKKLRQFGIFLLIILLSTYLPQTIGLYVTIILGLGADVYSL
                     ILTMGLVGSFLLLIWRLKKKKMLFIFEKKSWNWSFVFYLFATYVVYQILGNFWARYAH
                     LINHRNIHDEYFTVLFSNGQPTFLSTILSFVLPVIIGPVFEETLDRGYFMNTFFP"
     gene            34501..34695
                     /locus_tag="ACL8AS_000965"
     CDS             34501..34695
                     /locus_tag="ACL8AS_000965"
                     /EC_number="3.4.26.-"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family glutamic-type intramembrane
                     protease"
                     /protein_id="HGS1228845.1"
                     /translation="MILSHRDPISLLYYSLIGFFFALVYRSTDNLRLTILCHSFFNFL
                     NHAKPIWIFVYNYIYYHFFR"
     gene            complement(34745..35167)
                     /gene="nusB"
                     /locus_tag="ACL8AS_000966"
     CDS             complement(34745..35167)
                     /gene="nusB"
                     /locus_tag="ACL8AS_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000203663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_process: GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HGS1228846.1"
                     /translation="MTSPLLESRRQLRKCAFQALMSLEFGTDVETACRFAYTHDREDT
                     DVQLPAFLIDLVSGVQAKKEELDKQITQHLKAGWTIERLTLVERNLLRLGVFEITSFD
                     TPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ"
     gene            complement(35160..35549)
                     /locus_tag="ACL8AS_000967"
     CDS             complement(35160..35549)
                     /locus_tag="ACL8AS_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HGS1228847.1"
                     /translation="MGIEEQLGEIVIAPRVLEKIIAIATAKVEGVHSFSNRSVSDTLS
                     KLSLGRGIYLKNVDEELTADIYLYLEYGVKVPKVAVAIQKAVKDAVRNMADVELAAIN
                     IHVAGIVPDKTPKPELKDLFDEDFLND"
     gene            complement(35571..36131)
                     /gene="efp"
                     /locus_tag="ACL8AS_000968"
     CDS             complement(35571..36131)
                     /gene="efp"
                     /locus_tag="ACL8AS_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HGS1228848.1"
                     /translation="MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRD
                     VRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENE
                     LLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLV
                     VNVPDFIEAGQKLVINTAEGTYVSRA"
     gene            complement(36260..37702)
                     /gene="gatB"
                     /locus_tag="ACL8AS_000969"
     CDS             complement(36260..37702)
                     /gene="gatB"
                     /locus_tag="ACL8AS_000969"
                     /EC_number="6.3.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="HGS1228849.1"
                     /translation="MNFETVIGLEVHVELNTNSKIFSPTSAHFGNDQNANTNVIDWSF
                     PGVLPVLNKGVVDAGIKAALALNMDIHKKMHFDRKNYFYPDNPKAYQISQFDEPIGYN
                     GWIEVELEDGTTKKIGIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMR
                     SPEEAYAYLTALKEVIQYAGISDVKMEEGSMRVDANISLRPYGQEKFGTKTELKNLNS
                     FSNVRKGLEYEVQRQAEILRSGGQIRQETRRYDEANKATILMRVKEGAADYRYFPEPD
                     LPLFEISDEWIEEMRTELPEFPKERRARYVSDLGLSDYDASQLTANKVTSDFFEKAVA
                     LDGDAKQVSNWLQGEVAQFLNAEGKTLEQIELTPENLVEMIAIIEDGTISSKIAKKVF
                     VHLAKNGGGAREYVEKAGMVQISDPAILIPIIHQVFADNEAAVVDFKSGKRNADKAFT
                     GFLMKATKGQANPQVALKLLAQELAKLKEN"
     gene            complement(37702..39168)
                     /gene="gatA"
                     /locus_tag="ACL8AS_000970"
     CDS             complement(37702..39168)
                     /gene="gatA"
                     /locus_tag="ACL8AS_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0030956 - glutamyl-tRNA(Gln)
                     amidotransferase complex [Evidence IEA];
                     GO_function: GO:0050567 - glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA];
                     GO_process: GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="HGS1228850.1"
                     /translation="MTFNNKTIEELHNLLVSKEISATELTQATLENIKSREEALNSFV
                     TIAEEQALVQAKAIDEAGIDADNVLSGIPLAVKDNISTDGILTTAASKMLYNYEPIFD
                     ATAVANAKTKGMIVVGKTNMDEFAMGGSGETSHYGATKNAWDHSKVPGGSSSGSAAAV
                     ASGQVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGTVSRFGLIAFGSSLDQIGPFAPTV
                     KENALLLNAIASEDAKDSTSAPVRIADFTSKIGQDIKGMKIALPKEYLGEGINPEVKE
                     TILNAAKHFEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEDA
                     TNLDEIYVNSRSQGFGEEVKRRIMLGTFSLSSGYYDAYYKKAGQVRTLIIQDFEKVFA
                     DYDLILGPTAPSVAYDLDSLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFSQGLPVG
                     LQLIGPKYSEETIYQAAAAFEATTDYHKQQPVIFGGDN"
     gene            complement(39168..39470)
                     /gene="gatC"
                     /locus_tag="ACL8AS_000971"
     CDS             complement(39168..39470)
                     /gene="gatC"
                     /locus_tag="ACL8AS_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0030956 - glutamyl-tRNA(Gln)
                     amidotransferase complex [Evidence IEA];
                     GO_function: GO:0050567 - glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA];
                     GO_process: GO:0006450 - regulation of translational
                     fidelity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="HGS1228851.1"
                     /translation="MKITQEEVTHVANLSKLRFSEKETAAFATTLSKIVDMVELLGEV
                     DTTGVAPTTTMADRKTVLRPDVAEEGTDRDRLFKNVPKKDNYYIKVPAILDDGGDA"
     gene            39683..41227
                     /locus_tag="ACL8AS_000972"
     CDS             39683..41227
                     /locus_tag="ACL8AS_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HGS1228852.1"
                     /translation="MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVK
                     GKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMA
                     VDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILG
                     IASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDD
                     IELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLETFLKFAPEPHGHKKTDGE
                     IVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNV
                     TQFMAESRENVINAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVS
                     AKNVMKQKSFHKGIEQLVQEGAIQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAE
                     VVMNPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDV
                     ELEEKM"
     gene            41530..41824
                     /locus_tag="ACL8AS_000973"
                     /pseudo
     CDS             41530..41824
                     /locus_tag="ACL8AS_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163337.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 8 protein"
     gene            41943..42131
                     /gene="rpmB"
                     /locus_tag="ACL8AS_000974"
     CDS             41943..42131
                     /gene="rpmB"
                     /locus_tag="ACL8AS_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008536053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HGS1228853.1"
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKP
                     KKVWASARALKSGKVERV"
     gene            42288..42653
                     /locus_tag="ACL8AS_000975"
     CDS             42288..42653
                     /locus_tag="ACL8AS_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HGS1228854.1"
                     /translation="MTVKINTKDGQIELTDEVIATVVGGAATEIFGVVGMASKNALKD
                     NFQALLGKENYSKGVVVKAAEDGSIAVDVYTVLSYGTKISEVSKNIQERVAFSLENQL
                     GITAQTVNVYIQNIKVVGE"
     gene            42656..44323
                     /locus_tag="ACL8AS_000976"
     CDS             42656..44323
                     /locus_tag="ACL8AS_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HGS1228855.1"
                     /translation="MSKITTSLFQEMVQAASTRLNKQAEYVNSLNVFPVPDGDTGTNM
                     GMTIENGAKEVADKPASTVGEVASILAKGLLMGARGNSGVITSQLFRGFSQAIKDKDE
                     LTGQDLALAFQSGVEVAYKAVMKPVEGTILTVSRGAAIGAKKKAEQTDDTVEVMRAAL
                     EGAKTALAKTPDMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFVATPANM
                     SEMINVEHHKSVAGHVATEDITFGYCTEIMVALKQGPTYAKDFDYDEFRNYLDELGDS
                     LLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVDNMRNQHEAQVEKEATQVIKS
                     AEEKEYALIAVVAGKGLADIFCSQGVDYVIEGGQTMNPSTEDFIKAVEQVNARNIIFL
                     PNNKNIFMAAQSAAEVLEQPAVVVEARTLPQGMTSLLAFDPSKSIEENQERMTAALSD
                     VVSGSVTTAVRDTTIDGLEIHENDNLGMVDGKILVSNPDMHQTLTETLKHMLDEDSEI
                     VTFYVGEDGSEELANEIAQEIVEEFEDVEVEIHQGQQPVYPYLFSVE"
     gene            complement(44367..>44833)
                     /locus_tag="ACL8AS_000977"
     CDS             complement(44367..>44833)
                     /locus_tag="ACL8AS_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000530076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HGS1228856.1"
                     /translation="IKRYWKLIQQDSRKLSDKRFYRPTFRMHLTNKEILDKILSYSED
                     LKHHYQIYQLLLFHFQNKEPEKFFGLIEDNLKQVHPLFQTVFKTFLKDKEKIVNALQL
                     HYSNAKLEATNNLIKLIKRNAFGFRNFENFKKRIFIALNIKKERTKFVLSRA"
BASE COUNT        12939 a         8499 c        10078 g        13317 t
ORIGIN      
        1 ttcgtttctg tcgcatttta gcttgtaaat tgagtacttt catcaagcct tgaactcttt
       61 tatgatttac cagataacca cgatttctta gttctaaatg aacccggcga taagtataat
      121 ttcccttgtg ttcgataaaa atggattgaa tttcagcttt aagctcttgg tccttatctg
      181 gtttgtctag ctgtttcaag tgatagtagt aggtccaacg agctagttta atggctttta
      241 gaagaagatc taacgaaaac tcagtcatta attcttgaac aatttctatc tttcttcttt
      301 ctctttttcc tccttcaatc ggagttctct taactttttt aggatggcct tctccgctct
      361 caggtactca ttttctgctt gaagacgttc taattctgtc ctctcttcag gtctcttttt
      421 tggcttacgt ctcattttag gtactctccc tcttgttttc tcaacaatag tatacccgtt
      481 tttcctgtat tgtgctagcc agttaagaag tatcgtacga cttgggaggc cgtattcaag
      541 agaaactcta tctttagtcc agccttcata taagacttta ttaatcattt cttgttttaa
      601 atcaggagaa tagtaacgat ttttcccttt tttgacgaac tctattccgt aacgatcaat
      661 caatttaatc atatacctaa gattagaatt atttatccca aatttatttg aaagcttctc
      721 taagctatat ccttgttttc taagttcata gatctgaact ttatcatcat aagttaattt
      781 cataataaaa acaccccaaa agttagattt tttctgtcta acttttgggg tgtagttcat
      841 gtacacctga tatgatgcgt tttataattt ttaagccttt ttgcccagcc tcgtcaaaag
      901 taatgttttg acacaaaatc tgtgacaaaa ctttagtttt aaaggttttt aactttgtat
      961 atactagttt taagaaaagg aggatgatct aatggaagaa aaagtatcat tgaaagtcag
     1021 ggttcaaaaa ctagggacat cgctttcaaa tatggttatg cccaatattg gagcatttat
     1081 tgcttgggga gtattgactg ccctctttat cgctgatggc tatctgccaa atgaacagtt
     1141 agctactgtt gttggtccta tgttaacgta tttattgcca atcctgattg gttacacagg
     1201 tggatatatg atccatggcc aacgtggtgc cgttgtagga gctattgcta ctgttggtgc
     1261 aatcacaggt tctagtgttc ctatgtttat cggagctatg gtaatgggcc cactgggagg
     1321 atggactatc aagaaatttg atgagaagtt ccaagaaaaa attcgtcccg gatttgaaat
     1381 gttagttaat aacttctcag ctggtctcgt tggttttgca ttattgcttt tggctttcta
     1441 cgcaatcggt ccagtcgtat cgactcttac tggagctgtt gggaatggtg ttgaggctat
     1501 tgtcaatgct cgcctccttc ctatggctaa tattatcatc gaaccggcta aagtcctttt
     1561 cctcaataat gccctcaatc atggcatttt tactcctctg ggagtagaac aggtagctca
     1621 agctggtaag tcaattctct tcctattgga agctaatcct ggaccaggcc tgggaattct
     1681 attagcttat gctgtattcg gtaaaggttc tgctaaatct tcttcttggg gggcaatggt
     1741 tattcatttc ttcggaggga ttcatgaaat ttactttcct tatgttatga tgaagcctac
     1801 tctattttta gctgctatgg caggaggtat ctctggaact tttacttttc aactcttaga
     1861 cgctggtctt aaatctccag cttcaccagg ttctattatt gcgattatgg ctacggcgcc
     1921 aaaaggtgtt tggcctcatc taaatgttct tttaggtgtt ttagtggcag cagttgtttc
     1981 tttccttgta gcagccctta ttcttcatgc agacaagtca actgaggatt cgctcgaagc
     2041 tgctcaggcg gctacccaag cagctaaagg tcagttagta tcaacttctg ttgatgcagt
     2101 tgtttcgaca gactcagtgg aaaaaatcat tttcgcctgc gatgctggta tgggaagctc
     2161 tgctatggga gctagtattc ttcgagataa ggttaaaaaa gcaggtctag agattccagt
     2221 atctaatcag gcaatctcaa atttgcttga tacaccaaaa acattaattg ttactcagga
     2281 agaactgaca ccaagagcta aagacaagag tccaagtgct attcatgttt ctgttgataa
     2341 tttcttagcg tcccctcgtt atgatgaaat tgtagcttca ttaacaggag cttttccaat
     2401 agcagaaatt gaaggagata taccaacttc agcaccagta gatagtcagg aaattgacct
     2461 taaccatatt gatgctgtag tagttgctta tggtaaagca cagggaactg caactatggg
     2521 ctgtgaaacg attcgggcta tctttagaaa caagaatatt cgtattccag tttctactgc
     2581 caaaatttca gaattaggtg aatttaattc taaaaacata atgattgtaa caactatttc
     2641 tttacaggca gaagtgcagc aagcagcacc gaattctcaa tttcttattg tggatagttt
     2701 agtaacaaca ccagaatatg acaaaatggc tgctagaatg tacaaataga actagaggtt
     2761 tctaaattac gaatgctatt aaccaaacga gaagaacaat tattgaaggc tttcctacat
     2821 gtagggaagc tttcaatgca agatatgact gaaatcttac aggtttcatc tagaacaatt
     2881 tatcgaactt tatcagattt gacagatagc atggagcaat atggaatcga aataacgaag
     2941 catgggaaat actatatttt gactggagag ttggatgatt tgccgacaga acttgaagtg
     3001 ttagttgagt atagtcccca agaaagacaa gagttgatta cctatcgcct tctgactgag
     3061 agcggttttg tcaccaatga agcattgcaa gagtgcacga aagtcagtaa tgtaactatt
     3121 attcaggata tttcagatat tgataagcgt cttttagact ttgatctgaa aattgaacga
     3181 caaaaaggtt atcggatttc tggtgattca gttggtaaga gaagattttt ggctatttta
     3241 ctgacaaact gtatctcagt agcagatttt tcaaccggta attttgggag ctttgatatt
     3301 ttagaagcag atagaactag gctggccagt cagattgtta ataagcaact gtcaggtttt
     3361 ccagatatgg atgctaggat gaagatgttt tttgcgatct tgttatctct tataggtcag
     3421 gagcaaaaca ttgaaaattc acctaatact agtaagcagg ctttggaaat ttctcaaaaa
     3481 atttttcaaa cttactctaa gcagactgca caattttata gtattcagga aattatctat
     3541 tttgcgagca tcttggatga attaatcatt aaacgtcagg acaatccgct ctttacggag
     3601 aaatttgatg gtgaattttt ctacaatatt tcaaatctga ttgatacggt ttccatgtat
     3661 accaagattg acttttttaa ggacaaggtt ttattcaatt ttcttttcca tcatattcgg
     3721 ctcagtttag gcgtccctat cctttttcag ggtgaaaatt tgccagaatc tgtccagatt
     3781 ttagttgaaa ggaataaatt tctttataca gtcatcagtc ttttagtgaa tgatattttt
     3841 ccgaaatatc ttcatacaga gtatgagtat ggcatgattg ccctacattt tatctctagc
     3901 ttaggccgta gtccagagat ttatccagtc cgtgttttgc ttttaacgga tgaacgtcgg
     3961 gtcactagag atttattagt cagtaaaatt aagagtgttg ctccttttgt agagttgata
     4021 gatattcagt ctctagtaga ttaccacagt attgatctca gtcagtatga ttatatttta
     4081 tctaccaagc cgctgactaa tcaggaaatc ggtgtaattt ctagttttcc aaccgtcaaa
     4141 gaattgcttg aattacagga acgacttcag tatgtacagg cacatcgtac aattgtcgcg
     4201 cgtgatgcta tcgctccaga gaaaagttat gacttgcaag attatttaat atctagtagt
     4261 cagcttttga gtcaattcga gttggttcaa ttggagaata atcaatcatt tgagcacacg
     4321 gtagaacaaa tcatccaata tcagaagaat gtgagtgaca gagattacct aacaagaaaa
     4381 ttgttatctc acttccagaa tagtcctatg gctattccta atactggtct ggtgctttta
     4441 catagtcagt ctagcaaagt aacaacaaat agttttacta tgtttgaact caaactacct
     4501 atctccgcat tgtcaatgaa acgagaggaa gaagaggtca aaaggtgtct gctaatgcta
     4561 atgtctaaag aagctagcga ggaagctaga gatttaatga cagctattag tcagtcgatt
     4621 attgaaaatc atctttatac agagatttac aagacgggaa atcaatccat tatttatcag
     4681 atgctaaata ctatttttaa cgaaaaaatt aagaaattgg agaactaata tgaaacttga
     4741 aaaacatttg attaagctta ataaacaatt ttctaacaag gaggaagcta tttgttattg
     4801 tgggcaagtt ctttatgagg gtggatatgt taatgaagac tatattgaag ccatgattga
     4861 gcgagataaa gagctatctg tttacatggg taactttatc gccataccgc atggaacaga
     4921 tgcagcaaaa aatgatgtcc tcaagtctgg tattacagtc gttcaagtcc ctagaggggt
     4981 tgattttggg aatgtatcta accctcaagt ggcaacggtt ctttttggta ttgctggtat
     5041 tggtaatgaa cacttagaaa ttattcagaa aatttctatc ttctgtgcag atgtggataa
     5101 tgttcttaaa ctagcagatg ctcagtcaaa agaggaagta ttgcgcttat ttgatgctgt
     5161 tgaataattg aatttcgtca tttgtcatct agtatatatg tccctcaaat aggaaaagga
     5221 gaaattgaat gaaacattct gttcattttg gtgccggtaa tatcggtcgt ggttttatag
     5281 gtgaaattct atttaaaaat ggtttccata ttgattttgt ggatgtcaat aatcagataa
     5341 ttcatgctct aaatgaaaag ggcaagtatg aaattgaaat tgcacagaaa ggacagtctc
     5401 gtatagaagt aactaatgtg gctggcatta atagcaaaga acatcctgag caagtcattg
     5461 aagcgattca aaagacggat attattacta ctgcaatcgg acctaatata ctccctttta
     5521 tcgctgaact tctagccaaa ggaatcgaag ctcgccgagt tgcagggaat acacaggtat
     5581 tggatgttat ggcctgtgaa aatatgattg gcgggtctca atttctttat caagaagtca
     5641 agaaatattt aagtccggaa ggtttgacat ttgctgataa ctacataggt tttccaaatg
     5701 ctgcagtaga caggattgtt ccagcacaaa gtcacgaaga ttcccttttt gttgtggtcg
     5761 agccctttaa tgaatgggtc gtggaaacca agcgtcttaa aaatccagat ttacgtctaa
     5821 aagatgtgca ttatgaagaa gatttagaac cctttattga gcgaaaactt ttttcagtca
     5881 attctggaca tgcaacttca gcttacattg gtgcgcatta tggtgccaag acaattttgg
     5941 aagctcttca aaatcctaat atcaaatctc ggattgaatc tgtattagct gaaattcgga
     6001 gtctcttgat tgccaaatgg aactttgata aaaaagaatt ggagaattat cacaaagtca
     6061 ttatagaacg gtttgaaaat cctttcatag tggacgaggt tagtcgcgta gctcgtactc
     6121 caatccgaaa attaggctat aatgaacgat tcatccggcc gatacgtgaa ttgaaagaac
     6181 tcagtttgtc atataaaaac ctacttaaaa cagttggcta tgcctttgac tatcgcgatg
     6241 taaatgatga agaaagtatt cgattaggtg aattgttggc taaacaatca gtcaaagatg
     6301 ttgttataca agttacaggt ttagacgacc aagaattgat tgagcaaatt gtagagtata
     6361 tttaatcttt ttcgaaaatc tcttcaaatc aggttagcat cgctttgtct taggcatatg
     6421 ttgttctatc tacaacctca aagcagtgct ttgagctgac tccgtcagtc ttatctgcaa
     6481 cctcaaaaca ctgtttgagt tatctgcggt aatctttcta gcttgtcttt gatttttgtt
     6541 gttatttata aggtaaaaga agctggacaa aaagtcttca aaatcgggaa aaggcagcct
     6601 atcgggtgtt caaaaatctt gataggatgt cctttattat ggaaagcctt attggatttt
     6661 ctcctcagat tgagtttttg atcagcttta tgagataggt tttgctagag atgtagccca
     6721 tcatgttatt tttatggact gtgggaaaat tgttgaaaaa aataatgccc atcaattctt
     6781 tagtcgtcca agagaagaac gaaccaagca attttggaac gaattctttc gaatgcgatc
     6841 tatatagtaa aatgaaacaa gaacaggaca aatcgatcag gacagtcaaa tcgatttcta
     6901 aaaatgtttt agaagtagag gtgtactatt ctagtttcaa tatactatat aactaaaaaa
     6961 ttagataaat tagttttgga aaatgactaa ccaaaagata tccaaagtag tctaaaattg
     7021 tctatacttt atgagtgttt tagttaggaa aaaggcttgt tgtctataat tgtctgcatt
     7081 agtctagatt ttatttatag aaaatgttat aatagactgt atttaaaaaa ttttaaggag
     7141 aaatgacaga atgtctgtat catttgaaaa caaagaaaca aaccgtggtg tcttgacttt
     7201 cactatctct caagaccaaa tcaaaccaga attggaccgt gtcttcaagt cagtgaagaa
     7261 atctcttaat gttccaggtt tccgtaaagg tcaccttcca cgtcctatct tcgataaaaa
     7321 atttggtgaa gaatcacttt accaagacgt tatgaacgct cttttgccaa acgcttatga
     7381 agcagctgta aaagaagctg gtcttgaagt ggttgcccaa ccaaaaattg acgtaacttc
     7441 aatggaaaaa ggtcaagact gggttatcgc tgctgaagtc gttacaaaac ctgaagtaaa
     7501 attgggtgac tacaaaaacc ttgaagtatc agttgatgta gaaaaagaag taactgacgc
     7561 tgatgttgaa gagcgtatcg aacgcgaacg caacaacctg gctgaattgg ttatcaagga
     7621 agctgctgct gaaaacggcg acactgttgt gatcgacttc gttggttcta tcgacggtgt
     7681 tgaatttgac ggcggaaaag gtgaaaactt ctcacttgga cttggttcag gtcaattcat
     7741 ccctggtttc gaagaccaat tggtaggtca ctcagctggc gaaaccgttg atgttatcgt
     7801 aacattccca gaagactacc aagcagaaga ccttgcaggt aaagaagcta aattcgtgac
     7861 aactatccac gaagtaaaag ctaaagaagt tccagctctt gacgatgaac ttgcaaaaga
     7921 cattgatgaa gaagttgaaa cacttgctga cttgaaagaa aaataccgca aagaattggc
     7981 tgctgctaaa gaagaagctt acaaagatgc agttgaaggt gcagcaattg atacagctgt
     8041 agaaaacgct gaaatcgtag aacttccaga agaaatgatc cacgaagaag ttcaccgttc
     8101 agtaaatgaa ttccttggga acttgcaacg tcaagggatc aaccctgaca tgtacttcca
     8161 aatcactgga actactcaag aagaccttca caaccaatac caagcagaag ctgagtcacg
     8221 tactaagact aaccttgtta tcgaagcagt tgccaaagct gaaggatttg atgcttcaga
     8281 agaagaaatc caaaaagaag ttgagcaatt ggcagcagac tacaacatgg aagttgctca
     8341 agtacaaagc ttgctttcag ctgacatgtt gaaacatgat atcacaatca aaaaagctgt
     8401 tgaattgatt acaagcacag caacagtaaa ataatcttaa taaacagaaa acccacctga
     8461 attggtgggt tttctgatgc actattttcc aaaaatctct ttgaggtctg tgtctgtaat
     8521 cccaatcatg gctgggatgc ggttccagtt ttcttcggtt aggatgtagg attgttcaga
     8581 ggcacttgat gtgactgttt cagagacagc ttgttgcttt tcttcaacat tctccagtag
     8641 atcactgaag cgttcaatca gataggtttt tcgggcagtt ccgatgtgtt ggatagcatg
     8701 gtcgaaggct tgtaattcgc ctagtaagat gagtttgctt ttggcacgtg taatggctgt
     8761 gtagatgaga tttcgctcca gcatacgtcg gctagcacta gtaatcggta ggatgacaac
     8821 tgggaactca cttccctgag acttatgaat actcatggca taggccaagc gaatcttgta
     8881 ccattcgtta cgggggtaag agacttcatt accatcaaaa tcaatgacaa tctcgtcttg
     8941 tttcgattcg gtgtatttac caggaatcag gtctgtgata gctcctaaat ccccattaaa
     9001 gacattgatt tcagcatcgt taaccaaatg aatgaccttg tctctcttac gatagtggca
     9061 ctgaggagct tcaaaactga gttgatcttt ttgtggggga ttgagcaggt cttgcatgag
     9121 ctgattgata gcatcaatcc ctgccgtccc tcggtacata ggagccagaa cttggatatc
     9181 acgggcagga ataccatttc tgagggcagc acctaagatt ttttcaatgg tggcaggaat
     9241 atggccacta gcaatttcaa agtaggaacg gtcagctttt ttttgggtga aatcagctgg
     9301 caagatgccc tgtcgaatct gactagctag ggtgacgatg gttgattctt tgctttgtcg
     9361 ataaattttt tccaagcgag tctgaggaat caaaggaata tgaagcagat ccgctagaac
     9421 ctgtccagga ctgacagaag gtagctgatc actgtcacct acgatgagga tcttactgtt
     9481 agaagagata ttggagaaga gttgattggc cagccaagta tctaccatag agaattcatc
     9541 cacgatgata aagtcagcat ctaggtaatc ttccagatga ctggtatcat cgtcacctgt
     9601 cattcccaag tggcggtgta tggtcgcgct aggcaaacct gtcaattcat tcatgcggcg
     9661 agcggctcgt ccagttggag cagcaagaag aatgggcaga ttgcttttct tcctgaggtc
     9721 aagtccctct aacagggcgt aaacagcgat gatcccattg ataacagttg tcttaccagt
     9781 accaggtcca cctgtcagga taaagacctt attctggata gcatcacaga tagcctgttt
     9841 ttgaatgtta tcatactcaa ttcccagctc ttgctcgata gtagtgatat gtttttgaat
     9901 ggtttctaaa tgatgactct tctgttctcc tttttcaagg atacgaacca agtgactgcg
     9961 gatgccttcc tcagcgaaaa agaggctgtt gtcaaagatc ttggtatcaa tctgctgaac
    10021 cttgtcttct tcgatcaggt aggagagctc ttgggcaact tgactggggt ctagttccac
    10081 gggacgggaa gactcaagga gagtaagggt ttgttccagc aaatcccgtg cttcaacata
    10141 ggtgtcccct gtttccatac aggcctgaaa aagactgtga actagaccgg cgcggaagcg
    10201 ttcaggagcc tgactttcga tgcctagttc ctcagctagt tggtcagcaa tggtaaagcc
    10261 caaacccttg atatcctcaa ctagctggta gggataattt tcaaccacat caagggtttc
    10321 ttccttgtaa aagtcttgaa tctgaaaggc tagtttgttg ggaatgccgt agttggctag
    10381 tttggccaaa accatctccg ttccgtagtt gagacggaga gtggagacga aagcctcgcg
    10441 atttttggca gagagtcctg cgatgccttc taacttttct gggtgttgca aaatttcatc
    10501 aatggtattt tcgccatagg tatctacgat tttctgagct gtcttgagac caatcccctt
    10561 gaaatggcta cttgaaaagt acttgaccaa gcccttacta gttggttttg cgcgatcata
    10621 acgactgatt tgcagttgtt ctccatactt ggagtgctgg acaatttgcc cccaaaaagt
    10681 atagtcttcg ccctcaatta catcagccat ggttcctgtg acaatgattt caaagtcatc
    10741 aaaatcctct gcgtccgtat cgtcgatttc taggaggagg atgcgataaa aattgctggg
    10801 attttcaaaa ataatccgtt caatggttcc tgaaaaataa acttccataa aattcctttg
    10861 catgaatagg tgagagttgg gattgttttt attttatact cttcgaaaat atcttcaaac
    10921 cacgtcagct tccatctgca acctcaaaac agtattttga gctgacttcg tcagttctat
    10981 ccacaacctc aaaacactgt tttaagcagc ctacggctag cttcctagtt tgttctttga
    11041 ttttcattga gtatttgtaa ataaacaatc acttctcacg atagaagaag aggctgagat
    11101 tggtgattct cggcctctta ggtttcttaa aatgttccga tacgggtgat tggccataag
    11161 cggaatttag cttcccctgt gatatctttt gctttgaagg tacctacgtg gcggctgtcg
    11221 ctcgaaacca agcggtcatc tccgaggaga aggtattctc cttctggaac agtaaagcta
    11281 aagttggtgt tgtagttgac atcaactgtg aaggcttgag ctttttgagc gatacttcta
    11341 aagaaagttc ctttatttcc ttcaaagccc ttgcctgagt aagtgctttg gagtttgtca
    11401 tccttgaagc gtttgatata gtctgctaga taaggctcgt ccgtttcttt gtcattgatg
    11461 tagagtttat cattttcgta acgaatggtg tcgccaggca ttccaatcac gcgcttgacg
    11521 atgtccttat tcccatcttc ctcatgggcc accacgatat caaaacggtc aataggaagg
    11581 tgttttacaa cgaagagaat ttcgccatcc gctagggtcg gatccatgga atgtccttct
    11641 acgcgaacat tgctccaaaa aaagatacga cttaaagcta gtaatgacag aattaggagg
    11701 aacaatcccc actcttttaa gaaattttta aatgaattca taacttacct ttctaagcgt
    11761 tttttcgctt tttcagtgtt tttaaagtgc aatttggcgc agaagctgag tccctgcata
    11821 ccataggctt gcaaaatctg gctagccacc ttgtcagaag ccgttccagc tccacttgga
    11881 agctgataac ccagttctcg tcccaaattt tcaagatttt ccagaaagag atcacgcgca
    11941 atgacagaag aaactgcgac agccaagtat ttgccctcag ccttttcttc taagctgata
    12001 ggattgctga aacgattggt ctcttgtgcc aagtacttgt cataattttt agcactggta
    12061 aaggcatcaa tcacaatttt ctcaggctga acaccttttt gaaggaggag atagatagcc
    12121 tgattatgga gggcaacctt aaccgaaaca gcattgtagc ggtctccgat gacctcgttg
    12181 tacttgctgg gtgagagaag gagtgcctgg tgctggattt tttccttgag aataggagca
    12241 atctgacgga tcttttggtc ggtcagagtc ttagaatccc ccacaccgag ttttcgtaaa
    12301 aagtcgtgct ggtcaggtgt gacaaaggca gccacaactg caagcccacc aaagtaggaa
    12361 ccatttccca cctcatctgt cccaattaaa ggaagatttt gtccgctggt ttgctctaca
    12421 gcttgatagc caaagaaact ggcgtatttt tcagcccctt caccctgaag caagattttt
    12481 ccagaagtat agatagaaac cgttgcttga ggtagtttca aaaagtagcg gatataggga
    12541 ttcttgctag gagccagact ggtttgatag tgttcaagaa aagcctgaat atccttttcg
    12601 cttggtgtga gtgtgatact tgccatagtt tctattgtac cacaaaagca gtaaaatttg
    12661 taaaaactga caaaattagc gaattttggt ataatatcgt gaggtgaatt ttatggcaaa
    12721 tctaaatcga ttcaaattta cattcgggaa aaaatcgtta accttgacaa gcgaacatga
    12781 taaccttttt atggaggaaa tcgctaaggt tgcgacagaa aaataccaag caattaaaga
    12841 acaaatgcct agcgcagatg atgaaacaat cgctcttttg ttggcagtca actgtttatc
    12901 aactcagctc agccgtgaga ttgaatttga cgataaggag caagagctag aagaactccg
    12961 tcacaagctt gtgacttgta agcaagaaca gagcaagatt gaggattcct tatgatttca
    13021 ttccttcttc tattggtctt ggtttgggga ttttatatcg gctatcggag aggcctgctc
    13081 ttacaggttt attacctgat ttcagccatg gcatcggctt ttatggctgg ccagttttat
    13141 aaggggcttg gagagcaatt ccatttattg ctcccttatg caaattcgca ggaagatcag
    13201 gggactttct ttttcccatc ggatcaactc tttcagctgg ataaggtctt ttatgcaggt
    13261 atcggctact tgcttgtatt tgggattgtc tatagcattg gtcgtttgct tggtcttctc
    13321 ttacacttga ttcctagcca aaaactgggt ggtaagttgt tccaagtttc agcaggtatc
    13381 ttgtccatgt tggtgacctt atttgtcttg caaatggcct tgacaatctt ggcgaccatc
    13441 cccatggcag ttatacaaaa tcctcttgaa aagagtatcg tcgcaaaaca catcatccag
    13501 agcataccga taacaaccag ttggctcaaa caaatctggg tgacaaattt aatcggataa
    13561 aaagggcagg agttttccta gccctttgtt tacagatttg actcgaatct atcagaatgt
    13621 aaaaagctac cacacctaga cattcaaaga caaggaaata aagatgaata agaaaatatt
    13681 agaaacatta gagttcgata aggtcaaggc cttgtttgag cctcatttgt tgaccgagca
    13741 gggcttggag caattgagac aactggctcc gactgccaaa gcagataaaa tcaaacaggc
    13801 ttttgctgag atgaaggaaa tgcaggctct tttcgtcgag caaccgcatt ttactattct
    13861 ctcaactaag gaaattgcag gagtctgcaa gaggttggag atgggagcgg atctcaatat
    13921 cgaggagttc ctactcttga aacgcgtgct tcttgccagc cgagaacttc aaagttttta
    13981 cgccaatctg gaaaatgtca gcttggaaga attagccttt tggtttgaga aattacatga
    14041 ttttccgcaa ttacaaggaa atcttcaggc ctttaatgat gcgggtttca ttgaaaattt
    14101 tgccagtgaa gaattggcgc gaatccgtcg aaaaatacat gatagcgaga gtcaggtacg
    14161 cgatgtttta caagacttgc tcaagcaaaa agcgcagatg ttgacggaag gaattgttgc
    14221 tagcagaaat ggccgtcagg ttttaccagt caaaaacacc taccgcaata agattgcagg
    14281 tgtcgttcat gatatttctg ctagtggaaa caccgtctat atcgaaccac gtgaggtagt
    14341 caaactgagc gaagaaattg ctagtctgcg agcagatgag cgctatgaaa tgcttcgcat
    14401 tctccaagaa atttctgagc gtgtccgccc tcatgcggct gagattgcta atgacgcttg
    14461 gattatcggt catctggact tgattcgtgc caaggttcga tttatccaag aaagacaagc
    14521 agtcgtgcct cagctgtcag aaaatcaaga gattcaactg ctccatgtct gccatccttt
    14581 ggtcaaaaat gccgtcgcaa atgatgtcca ttttggtcaa gatttaacag ctattgtcat
    14641 tacaggtccc aatacaggtg ggaagaccat catgctcaaa actctgggct tgacacaggt
    14701 catggcccag tcaggattgc cgattttagc agacaaggga agtcgtgttg gtatttttga
    14761 agaaatcttt gctgatattg gagatgagca gtctattgag cagagcttgt ctaccttctc
    14821 tagccatatg accaatatcg tggatattct tggtaaggtc aaccaacatt cactcttact
    14881 tttggatgag ttgggggctg gtactgatcc ccaagaggga gcagcccttg ccatggctat
    14941 tctggaggac cttcgcctgc gtcaaatcaa gaccatggcg acgacccact atccagaact
    15001 caaggcctac ggtattgaga cagcctttgt gcaaaatgcc agtatggagt ttgatactgc
    15061 aactcttcgc ccgacctatc gctttatgca gggtgttcct ggccgaagta atgcctttga
    15121 aattgccaaa cgtctaggcc tatctgaagt tatcgtagga gatgccagtc agcagatcga
    15181 tcaggacaat gacgtcaatc gtatcattga gcaattagaa gagcagacgc tggaaagccg
    15241 caaacgtttg gacaatatcc gtgaggtgga gcaagaaaat ctcaagatga accgtgcgct
    15301 aaaaaaactc tacaacgagc ttaatcgtga aaaggaaacc gagcttaaca aggcgcgtga
    15361 acaggctgct gagattgtgg atatggccct aagtgaaagt gaccagattc tcaaaaatct
    15421 ccacagtaaa tcccaactca agccccacga aatcattgaa gccaaggcca agttgaaaaa
    15481 attggctcct gaaaaagtgg acttgtctaa aaacaaggtc cttcaaaagg ctaagaaaaa
    15541 acgagctcca aaggtgggag atgatatcgt ggttctcagt tatggtcagc gtggtacctt
    15601 gaccagtcaa ctcaaggacg gccgctggga agcccaagtt ggcttgatta agatgacctt
    15661 ggaagagaaa gagtttgatc ttgttcaagc ccagcaagaa aaaccagtca agaagaaaca
    15721 ggtcaatgtt gtgaaacgaa cttctgggcg aggacctcaa gctagactgg atcttcgagg
    15781 caagcgctat gaagaagcca tgaatgagct agataccttc atcgaccaag ctttgcttaa
    15841 caatatggct caagttgata tcatccatgg tatcggaaca ggagtcatcc gtgaaggagt
    15901 taccaaatac ttgcaaagaa acaaacatgt caagagtttc ggctatgccc cacaaaatgc
    15961 tggaggcagt ggtgcgacta ttgtcacttt taaaggatag cagtattctg gactttataa
    16021 agtaaaaact gttgaactaa tttttactaa taaacacatt gacaaaagcc aacatttttt
    16081 gtaaaattag aatcaattaa taccaacacc gaatgaagtt taatagaagt ggggaatcgt
    16141 ttgattttcc atgactgtaa atggacggaa ctctggagag accgtaaagg caccgaaggg
    16201 gcaaggcagg caactgctca aactctcagg taaaaggaca gagctaggat agaccgcttt
    16261 ttagcattta tctaagcatt ccagagtaca tgtatcttgc atgtgctctt tcttttgggg
    16321 ttgaaacgat aggagaagga aatgttagaa ttgcttaaat caatcgatga ttttgcttgg
    16381 ggaccgcccc tcttgatttt attggtcgga acaggggttt acctaaccat gcggctagga
    16441 ctcttgcagg ttttgcgtct gcccaaggcc tttcagctta tttttatcca ggataaggga
    16501 catggtgatg tatccagttt tgcagctctg tgtacagcct tggcatcaac tgttggaaca
    16561 ggaaatatca taggagttgc gacggctatc aaggttggtg gaccaggagc tctattttgg
    16621 atgtggatgg cggctttctt tggaatggct accaagtatg cggaaggact cttggccatc
    16681 aaataccgca ccaaggacga ccatggtgca gtagcgggag gtcccatgca ctatatcctt
    16741 ctagggatgg gagaaaagtg gcgaccactt gctgttttgt ttgcagtagc aggagtattg
    16801 gttgctctct tgggaatcgg aaccttcacc caagtcaact cgattacaga atctatccaa
    16861 aatacaacga cgatttcgcc agccatcaca gctctcgtct tgtctgtctt tgtagcgatt
    16921 gcagtctttg gtggactcaa gtctatttct aaggtttcaa ctactgttgt tccttttatg
    16981 gccatcattt atatcttagg aactcttaca gttattttct ttaatatcgg aaaaatccct
    17041 ggcacaatcg ctttagtctt tacctcagct tttagtcccc ttgctgcggt aggtggattt
    17101 gctggtgcta gcgttcggat ggctattcaa aatggtgtgg cgcgtggtgt gttctcaaac
    17161 gaatctggtc tgggttctgc tcctattgca gctgcagctg ccaagacaaa tgaaccagta
    17221 gagcaaggtt tgatttccat gacaggaacc tttattgata ccctcatcat ttgtactcta
    17281 actggtttga ccatcttggt aactggagtt tggagtggtg acttgaatgg ggttgccttg
    17341 actcagtcag ctttctcaac agtcttttca cactttgggc ctgccctctt gaccatcttc
    17401 cttgtacttt ttgcctttac aacgattcta ggttggaact attacggaga acgctgtttt
    17461 gagttcctct ttggggttcg ctttatctgg ctctaccgtg tggtttttgt gctcatggtc
    17521 ttgttaggag gatttatcga gttggatatg gtctggatta tcgcagatat cgttaacgcc
    17581 ttgatggctc tgccaaactt gattgccctc ttggtcttgt cgccagtcgt tattgctgaa
    17641 actaaaaagt attttgacaa ataatggaat cacacagctc gtgtgatttt tttgcctata
    17701 aataattttt atcagcctga tatataatat atattatgca agtgattgga agtgtgataa
    17761 actaatataa caacgaaaat cttatgagag aataaagctt tatcttagat aaacttagga
    17821 atcaggattt tataagattt tccaataata ttagtgtcaa taataagaaa agaggtatct
    17881 tatgacaaca tttactatcc atacagtaga gtcagcacca gcagaagtga aagaaattct
    17941 tgaaacagta gaaaaagaca acaatggcta tattcccaac ctaatcggtc tcttggccaa
    18001 tgccccgact gttttagaag cctaccaaat tgtctcatct atccaccgtc gcaacagcct
    18061 gacacccgtt gagcgtgaag tggtgcaaat cacggcagcc gtgaccaatg gttgtgcctt
    18121 ctgtgtcgca ggtcacacag ccttttccat caaacaaatc cagatgaatg atgacttgat
    18181 tcaagctctt cgcaatcgta ctccaattga aacagatcct aaattggata ccctagctaa
    18241 gtttaccttg gcagttatca ataccaaggg tcgtgtagga gatgaagcct tgtctgagtt
    18301 tttagaagct ggctacactc aacaaaatgc cttggatgtg gtttttggtg tcagcctagc
    18361 aatcctctgt aactatgcca acaacttagc taatacacca attaatccag aattgcaacc
    18421 ttatgcctaa ttcatatctg agtaaaatga agtctgaaat aagcggactt cgttttttta
    18481 aatcctcatt taagcgcttt tatgttatac tgaaactaac atgattattg gaggttagga
    18541 tgaaaaaact ccccttagta ttttcaggtt gtttgctagg tttggcagga gctggaaatc
    18601 ttattttaga tacgttgccg gttctatccc atctttttag tctgactggt ttggttttat
    18661 ggatttactt tctaattctg catctcttta attggaaaga aaccaagcaa gaattgacca
    18721 agccccctct tttgtcagga atggcaacct ttcctatggc tgggatgatt ttatcgacct
    18781 atgtctttcg cgtattctct tatcttcctt tggtagcaca agggatttgg tggttttcat
    18841 ttctcttgga tttgaccttg attgctggtt ttaccatcaa gtttgcttgt ccagggcgga
    18901 gggttcatgc cactccaagc tggacggttc tctatgtggg gatagcagtg gctgccttga
    18961 cctatcctct ggtaggtatt atcgaaattg cctatgcgac cttgagtttt ggttttctct
    19021 tgaccttcta tctctatccc cttatttata gcgatttaaa gaaacatcca ctcccactag
    19081 ccttgcttgg acaagaagga atctactgtg ctcctttctc tctactcttg gcttctctag
    19141 ttcgagtagg aggaaccagc ctgccgactt gggtcttgat tgtcatgatt ttggcttctc
    19201 aatccttctt tttctttgtt ttaactcgtc tgcccaacat tttaaaacaa ggttttcaac
    19261 cagccttctc agccctcacc ttcccaacca ttatcacagc gacctcgctc aagatggctc
    19321 agggaatttt gaaacttcca tttctggatt acctggtatt ggctgaaacc attatatgcc
    19381 taactatttt attctttgta ctaggtgctt atctgatttg gttacgaaaa aaggtctagc
    19441 tagaaatagc taaaccttat tttttatggt ttgatgactt cagctccacc catgtatgga
    19501 cgaagtgctt ctgggatggt cacagaacca tcttcatttt ggtaattttc aagaattgca
    19561 gccactgtac gtccaactgc aagtccagaa ccgttcaagg tatgaaggag tttcaccttg
    19621 ccatctgctt catcacggta acggatttgg gcacgacggg cttggaaatc ttctgtgttt
    19681 gaacagcttg agatttcacg gtaattgttt tgtgctggaa tccacacttc caagtcgtaa
    19741 gtcttcgtag ctgagaagcc catatctcca gtagagagag caacgacacg gtatggaagg
    19801 ttgagttttt gaagaatgtt ttcagcgttg gctgtcattt tttccaattc ttcgtaagat
    19861 tcttctggtt tggcaaattt gaccatttca accttgtgga attggtgcaa acggatcaag
    19921 ccacgcgtat cacgaccggc agaaccagcc tcagaacgga atgacggact catagcagtg
    19981 aagtagattg gaagatcttt gccgtctaag atttcatcac ggtagtagtt tgtcagagga
    20041 acttcagcag ttggaatcaa gacaaagttg gtatcgctga gttcaaaagt atcttcctta
    20101 aattttggat actgaccagt accaaacata gaatcatggt tgactatgta aggtgtgatg
    20161 acttcagtat agccttcttt tccatgttca tccaacataa agttgtagat agcacgttcc
    20221 aaacgagcac cgaggccttt atagaagagg aagcgagcgc ctgttacctt accaccgcgt
    20281 tcccagtcaa ggataccaag gtcttcaccg agatcccagt gagctttagg ttcgaagtca
    20341 aactcgcgtg gagtacccca acggcgaact tccacattgt cgtcttcgtc agccccaaca
    20401 ggaacgctgt cagctgggat atttggaaga gtcgttgtaa attctgtcaa tttagcatcg
    20461 atttctgcca attcagcatc caaggcttta acctcagcag atagattttg catggcagca
    20521 atcttgtcat ctgtattttc cttgttgcgc ttagcttggg caatctcagc agaaactgtg
    20581 ttacgttctg ctttgagagt ttcaaccttg atcaagatgt tacgacgttt agcatcgatt
    20641 tctttcattt cattcaagac agcagcatct acaccacgtg tagctaattt ttctgcgaca
    20701 gcttcaaaat ctgtacgaat acgtttgata tctaacataa gaactccttt atgaaaaaag
    20761 cacgcctgac aaaacgttgg agtggcaggg ccacggttcc atccaacttc acaggtgtgc
    20821 acttgattgt gtatgtaatt gttactaacg gtagaatttc acctatccct cctatctgct
    20881 cgcagtaccc gcagactttc tgaaagaaga agataaccta cttatccgtt gctatgatta
    20941 tactaaagtt tctacttttt tgcaaataga tttttaaatt tttggctaat tgtctgaatc
    21001 agggtcggaa gtttgacgac cttgtcattg cctagttttt tgcgtgcaat tttgagaatg
    21061 gcacctgagt cttttgaagc aaagaggaat tttcctttgt ctgtaaagac ttcgaagtgg
    21121 cggctgattt tgcgtccagt gacattggct ccaatctgat tgatatggct ccaaggaatc
    21181 tggataaatt gttcgacatt gacatctggg taaaattcca aagcctgatc tccgacaagg
    21241 aatttcccaa ctttcccagc gatagagagg taggaagtgc ctgtcgtact gaggagtact
    21301 gttttgttaa gtgattgagc catgcttagt cttccttact ttctccaaaa aaggcattgt
    21361 agagggcttt aattgctgct ttctcttggt ctttattgac aacaaacata atagaaactt
    21421 cactagaacc ttgagacatc atctggatgt tgattttgtt ttcagataga gcgcgtgtcg
    21481 cagtagcagt cactccgata tggctcttca ttttttcacc aacaatcata atgatagaaa
    21541 ggtcgtgttc gatttctgca tgatctactt tagccttttg aaccaactga cgcaggattt
    21601 cttcttcctt gatgggagtt agttggcgag aacggagaat gatagaaaga tcgtcgatac
    21661 ctgttggcat atgttcccaa ccgatgttaa gttcttccag gatttgcaga accttgcggc
    21721 caaatccaac ctcacggttc atgaggtatt tcgacatgtt aatgctgaca aagcctgagt
    21781 caccagcaat tcccacaact ggaaattcat cattactgtg ttttagaacg atacgagtac
    21841 ctggatggtc agggttgttg gtattcttga taaccagagg aatttttcca cggtaggcag
    21901 gaagaagagc ctcgtcatga aggactgaga agcctgcata ggccaactcg cgcatttcac
    21961 ggtaggtcaa ctcaggaatc gagtgtggtt ggtggataat accagggtga gctgcaaaga
    22021 taccatcaac gtccgtaaag ttttcataga ggtcagcttt gacaccagca gcaatgatag
    22081 aacctgtaat atcagaacct ccacgtgaga aagtacagat ttgattttcc ttagtgacac
    22141 caaagaaacc aggaatgaca aggacttcat tggtgtttgt caattcttca atcttgtcat
    22201 aacttgatgg aatgatgcga gcgtgaccag gttcacttgt gaccacaatc ccagcttctc
    22261 tagggtgcat atagcgtgca tcgataccat tttggttaaa gtaggcagca atcaatttgg
    22321 cattgttatt ttcaccggct gctaggaaag tatcgtagag aaattcattt tcttcaatag
    22381 gaagagtggc caaggcgtga atacttttag aaattttttc tagcacagct ggttttagtc
    22441 ccaattcact aaccatagca gcatagcggt cgataatcca gctttggctc ttgctaatat
    22501 cgttacccgc aacatagtcg cggtagtatt taatcagggc atccgtaacc ttagtatctt
    22561 cagcattgcg tttaccaggc gcagaaacga ctacaaaacg acgctctgaa tcacttttga
    22621 cgatgtttaa aactttttct aattgactag cagaggcaag agaactacct ccaaatttaa
    22681 caactttcat aagaactcct aaagtaagta ttttatacga ttatagcaga aagaaaggct
    22741 tttttcaatg aagaaaataa gatgctttct agcctaaagc gagcctttct tatcggctga
    22801 gacactttca gtcgattttt tcttgctttc tgctcctaaa aaagatatac tttgacagtg
    22861 aaataattta acactcaatg aaatcaaaga gcaaactagg aagctagccg cagactgctc
    22921 aaagcactgc tttgaggttg taaataagac tgacgaagtc agctcaaaat actgttttga
    22981 ggttgcagat ggaagctgac gcggtttgaa gagattttcg aagagtataa actgcttata
    23041 aaataaaaag gagccctgat ggaacacatt atttatcagc ttgaagagga cttggcaatc
    23101 cttaccttga accgtcctga ggtcgcaaat ggttttcata ttcccatgtg tgaggagatt
    23161 ttagaagctc tgactttggc agaagaaaat ccagctgtgc attttatctt aatcaatgcc
    23221 aatggaaagg tcttctcagt tgggggagat ttggtagaga tgaagcgggc agtggatgag
    23281 gatgatattc catcattgac aaaaatcgca gagttggtca atacgatttc ttataaaatc
    23341 aagcaaatag ccaaacctgt tttaatggaa gttgacggtg ctgttgcagg tgccgcagcg
    23401 aatatggctg ttgcggcaga tttctgtttg gcgacggata aggctaagtt tatccaagcc
    23461 tttgttggtg ttggtttggc tccagatgca gggggaattc atctcttgag ccgcagtatc
    23521 ggtgtgacgc gtgctgctca attagctatg acaggagagg ctttaacggc agaaaaagcc
    23581 ctagaatggg ggttggttta ccgcgtttct gaagctgaaa aacttgaaaa gacgagagaa
    23641 cagcttctta aaaaattaag acgtgcttca agtaattcct atgctgccat taagaagttg
    23701 gtttgggaga gccaatttaa agactggcag ggttacgcta ctttagaact gaacctacag
    23761 aaatccttag ctcaaacaga ggatttcaaa gaaggagtgc gagctcattc ggagagaaga
    23821 agacctaaat ttacaggaaa ataaaaaata cttgcatcat tctttgaatt ttgatataat
    23881 tctttctgtc aaatgttttg attgtaaaag ttttttgaag aaggagggat atgaaaaatg
    23941 gactaccaac gaatcaatga atatttaaca tctatattta acaatgtcct tgtaattgag
    24001 gaagtgaact tgagaggtag tcgttttaag gatatctcca tcaaagaaat gcatacgatt
    24061 gatgtcatcg gtaaggctcc agatgtgact ccaagtcaag tgtcaaaaga gttgatggta
    24121 actcttggaa ctgttacgac aagtttgaac aatttagagc gtaagggcta cattgagcga
    24181 gttcggtcag aacaggatcg tcgtgtggtg catctgcatt tgacaaagaa gggtcgcttg
    24241 attcatagac tgcataaacg cttccacaag gccatggtag aaaaaattat tgatggcatg
    24301 agcgaggaag aaattgctgt catgggtaaa ggcttgacta atctttacca atttttggag
    24361 gatttgaaat aatggctttt gcaaaaataa gtcaggttgc tcattatgtg ccagagcaag
    24421 tggttacaaa tcacgacttg gctcagatta tggataccaa tgatgagtgg atttcaagtc
    24481 gaacgggaat acgacaaagg catatttcaa gaacagaatc taccagtgat ttggctacag
    24541 aggttgctaa gaaactgatg gcaaaagctg gaataacagg aaaagaactg gattttatca
    24601 tcctagctac cattactcca gattcgatga tgccctctac agctgctcgt gttcaagcta
    24661 atattggcgc taataaagcc tttgcttttg acttaaccgc ggcttgcagt ggatttgtat
    24721 ttgctctttc aactgctgaa aagtttatcg cttctggtcg ctttcaaaaa ggcttggtga
    24781 ttggtagtga aaccctctct aaggcagtcg attggtcgga tcgatcaaca gctgtgttgt
    24841 ttggagatgg tgctggtggt gtcttgttag aagctagcga gcaagagcat ttcttagctg
    24901 agagtctcaa tagcgatgga agtcgcagcg agtgtttaac ttatgggcat tcaggtttgc
    24961 attctccatt ttcagatcaa gaaagtgcag attcgttttt gaagatggat ggacgcacag
    25021 tctttgattt tgccattcga gatgtagcca agtctatcaa gcagactatt gatgaatctc
    25081 ctatagaggt gacagacttg gattatctgc tacttcatca agccaatgac cgtattttgg
    25141 ataagatggc tagaaaaatt ggtgttgacc gagccaaact tccagccaat atgatggaat
    25201 atggcaatac cagtgcagcc agtatcccga ttttactttc agagtgtgta gaacaaggtc
    25261 tcatcccttt agatggtagc cagactgttc ttctatcagg cttcggtgga ggcttgacct
    25321 ggggcacgct cattcttaca atttaggtaa tcatgtggtg aacacattgt tataaaaaaa
    25381 ctatttattt taaaggagtc ctatcatggc agtatttgaa aaagtacaag aaattatcgt
    25441 tgaagaactt ggaaaagacg catcagaagt aacacttgaa tcaacttttg atgatttgga
    25501 cgcagattca ttggacttgt tccaagtaat ctcagaaatc gaagatgctt ttgatatcca
    25561 aatcgaagca gaaaatgact tgaaaacagt tggtgacttg gttgcttacg ttgaagagca
    25621 agcaaaataa gcagaatatt agtagaagga gtagggagaa acccactccc tcttgtttag
    25681 gtaatagttt gactgtcaaa ttatggtgaa atcgaactat tacgtaagca aggaaggttg
    25741 gaggcactat gaaaacgcgt attacagaat tattgaagat tgactatcct attttccaag
    25801 gagggatggc ctgggttgct gatggtgatt tggcaggggc tgtttccaag gctggaggat
    25861 taggaattat cggtggggga aatgccccga aagaagttgt caaggccaat attgataaaa
    25921 tcaaatcatt gactgataaa ccctttgggg tcaacatcat gctcttatct ccctttgtgg
    25981 aagatatcgt ggatctcgtt attgaagaag gtgttaaagt tgtcacaaca ggagcaggaa
    26041 atccaagcaa gtatatggaa cgtttccatg aagctgggat aatcgttatt cctgttgttc
    26101 ctagtgtcgc tttagctaaa cgcatggaaa aaatcggtgc agacgctgtt attgcagaag
    26161 gaatggaagc tggggggcat atcggtaaat taacaaccat gaccttggtg cgacaggtag
    26221 ccacagctat atctattcct gttattgctg caggaggaat tgcggatggt gaaggtgctg
    26281 cggctggctt tatgctaggt gcagaggctg tacaggtggg gacacggttt gtagttgcaa
    26341 aagagtcgaa tgcccatcca aactacaagg agaaaatttt aaaagcaagg gatattgata
    26401 ctacgatttc agctcagcac tttggtcatg ctgttcgtgc tattaaaaat cagttgacta
    26461 gagattttga actggctgaa aaagatgcct ttaagcagga agatcctgat ttagaaatct
    26521 ttgaacaaat gggagcaggt gccctagcca aagcagttgt tcacggtgat gtggatggtg
    26581 gctctgtcat ggcaggtcaa atcgcagggc ttgtttctaa agaagaaaca gctgaagaaa
    26641 tcctaaaaga tttgtattac ggagccgcta agaaaattca agaagaagcc tctcgctggg
    26701 caggagttgt aagaaatgac taaaacagcc tttttatttg ctggtcaagg tgcccagtat
    26761 ctagggatgg gacgggattt ctatgatcag tatccgattg tcaaagaaac gattgatcga
    26821 gcgagtcagg tgctcggtta tgatttacgt tatctcatcg atacggaaga agacaaactc
    26881 aatcagaccc gctatacgca accagccatt ctagcgactt cggttgctat ctaccgttta
    26941 ttgcaagaaa agggctatca gcctgatatg gttgctggtt tgtctcttgg agaatactct
    27001 gccttggtgg caagcggcgc cttggatttt gaagatgcgg ttgccttggt agctaagcgt
    27061 ggagcctata tggaagaagc ggctcctgct gactctggca agatggtagc agttctcaat
    27121 acgccagtag aggtcattga agaagcctgt caaaaagctt ctgaacttgg agtggttact
    27181 ccagccaact ataacacacc tgcacaaatc gtcattgctg gagaagtggt tgcagttgat
    27241 cgagcggttg aacttttgca agaagcaggt gccaaacgct tgattcctct taaggtgtca
    27301 ggtccctttc acaccgctct ccttgagcct gctagccaga aactagctga aactctagct
    27361 caggtaagtt tttcagattt tacttgtccc ctagtcggca atacagaagc tgctgtgatg
    27421 caaaaagagg acattgctca gctcttgacg cgtcaggtca aggaacccgt tcgtttctat
    27481 gaaagtattg gggtcatgca agaagcaggc ataagcaact ttatcgagat tggaccgggg
    27541 aaagtcttgt caggttttgt taaaaaaatt gatcaaactg ctcacttagc tcatgtggaa
    27601 gatcaagcga gtttagtagc acttttagaa aaatagacta aaataagtag aagttttgaa
    27661 aggaaaaaaa tgaaactaga acataaaaat atctttatta caggttcgag tcgtggaatt
    27721 ggtcttgcca tcgcccacaa gtttgctcaa gcaggagcca acattgtctt aaacagtcgt
    27781 ggggcaatct cagaagaatt gctcgctgag ttttcaaact atggtatcaa ggtggttccc
    27841 atttcaggag atgtatcaga ttttgcagac gctaagcgta tgattgatca agctattgca
    27901 gaactgggtt cagtagatgt tttggtcaac aatgcaggga ttacccaaga tactcttatg
    27961 ctcaagatga cagaagcaga ttttgaaaaa gtgctcaagg tcaatctgac tggtgccttt
    28021 aatatgacac aatcagtctt gaaaccgatg atgaaagcca gagaaggtgc tatcattaat
    28081 atgtctagtg ttgttggttt gatggggaat attggtcaag ctaactatgc tgcttctaag
    28141 gctggcttga ttggctttac caagtctgtg gcacgcgagg tcgctagtcg gaatatacga
    28201 gtcaatgtga ttgctccagg aatgattgag tctgatatga cagctatctt atcagataag
    28261 attaaggaag ctacactagc tcagattccg atgaaagaat ttgggcaggc agagcaggtt
    28321 gcagatttga cagtattttt agcaggccaa gattatctaa ctggtcaagt ggttgccatt
    28381 gatggtggct taagtatgta gcgaaagcta gaggtgaaaa gaatgaaact aaatcgagta
    28441 gtggtaacag gttatggagt aacatctcca atcggaaata caccagaaga attttggaat
    28501 agtttagcaa ctgggaaaat cggcattggt ggcattacaa aatttgatca tagtgacttt
    28561 gatgtgcata atgcggcaga aatccaagat tttccgttcg ataaatactt tgtaaaaaaa
    28621 gataccaacc gttttgataa ctattcttta tatgccttgt atgcagccca agaggctgta
    28681 aatcatgcca atcttgatgt agaggctctt aatagggatc gttttggtgt tatcgttgca
    28741 tctggtattg gtggaatcaa ggaaattgaa gatcaggtac ttcgccttca tgaaaaagga
    28801 cccaaacgtg tcaaaccaat gactcttcca aaagctttac caaatatggc ttctgggaat
    28861 gtagccatgc gttttggtgc aaacggtgtt tgtaaatcta tcaatactgc ctgctcttca
    28921 tcaaatgatg cgattgggga tgccttccgc tccattaagt ttggtttcca agatgtgatg
    28981 ttggtgggag gaacagaagc ttctatcaca ccttttgcca tcgctggatt ccaagcctta
    29041 acagctctct ctactacaga ggatccaact cgtgcttcga tcccatttga taaggatcgc
    29101 aatgggtttg ttatgggtga aggttcaggg atgttggttc tagaaagtct tgaacacgct
    29161 gaaaaacgtg gagctactat cctggctgaa gtggttggtt acggaaatac ttgtgatgcc
    29221 taccacatga cttctccaca tccagaaggt cagggagcta tcaaggccat caaactagcc
    29281 ttggaagaag ctgagatttc tccagagcaa gtagcctatg tcaatgctca cggaacgtca
    29341 actcctgcca atgaaaaagg agaaagtggt gctatcgtag ctgttcttgg taaggaagta
    29401 cctgtatcat caaccaagtc ttttacagga catttgctgg gggctgcggg tgcagtagaa
    29461 gctatcgtca ccatcgaagc tatgcgtcat aactttgtac caatgacagc tgggacaagt
    29521 gaagtatcag attatatcga agctaatgtc gtttatggac aaggcttgga gaaagaaatt
    29581 ccatacgcta tttcaaatac ttttggtttt ggaggccaca atgcagttct tgctttcaaa
    29641 cgttgggaga atagataagt atgaatttaa acgatattaa agacttgatg actcaatttg
    29701 accagtcaag tttgagagaa ttttcttata aaaatgggac ggatgagttg cagtttagca
    29761 agaatgaagc gagacctgtg cctgaagttg caactcaagt cgctccagca cccgttctag
    29821 caacaccgag tccagtagct cctacatctg ctccagcaga gactgtagca gaagaagttc
    29881 cagctccagc tgaagcaagt gtggctagtg agggaaatct tgtagagagt ccacttgttg
    29941 gagtggttta cttggctgct ggaccagata aacctgcctt cgttacagtt ggtgatagtg
    30001 tcaaaaaagg tcaaacattg gtaattatcg aagccatgaa agtcatgaat gaaatcccag
    30061 ctcctaagga tggtgtggta acggaaattc tcgtctctaa cgaagaaatg gttgagtttg
    30121 gtaaaggatt ggtacgtatc aaatgatcga tattcaagga atcaaagaag ctcttcccca
    30181 ccgttatcct atgcttctag tggaccgtgt cttggaagtg agcgaggata ccattgttgc
    30241 tatcaaaaat gtgaccatta acgaaccttt ctttaacggc cactttcctc aatacccagt
    30301 tatgccaggt gttctgatta tggaagcctt ggcgcaaact gctggtgtgt tggagttatc
    30361 aaaacctgaa aataaaggaa aactggtctt ttacgctggt atggacaagg ttaagttcaa
    30421 gaagcaagtt gtaccaggcg accaattggt tatgacagcg acttttgtaa aacgtcgtgg
    30481 caccatagct gtggttgaag caaaggctga agtggatggc aagcttgcag ccagtggtat
    30541 ccttactttt gcaattggga actaaggagg ttctccatgt ttcgaaaaat tttaattgcc
    30601 aatcgtggtg aaattgcggt tcgtattatc cgtgcggcac gtgaattggg gattgcgacg
    30661 gtagcggttt attcaactgc tgataaggaa gctcttcata cgcttttggc agatgaagca
    30721 gtttgtattg gtcctggcaa ggcaacagag tcttatctca atattaatgc agttctatca
    30781 gctgcagtct tgactgaggc agaagctatt caccctggtt ttggatttct cagtgaaaat
    30841 tccaaatttg cgaccatgtg tgaagaagta ggtatcaagt ttatcggtcc atctggtcat
    30901 gttatggata tgatggggga taagatcaat gcgcgtgctc agatgattaa agcaggtgtg
    30961 cctgttatac caggttcaga tggagaagtg cataactctg aagaagcttt gattgttgct
    31021 gaaaaaattg gctatcctgt tatgctcaag gcttcagcag gtggaggtgg taaagggatt
    31081 cgtaaggttg aaaaaccaga tgacctcgtt tctgcctttg aaactgcctc tagtgaggcc
    31141 aaggccaatt atggcaatgg tgccatgtac atagaacggg ttatctatcc agctcggcac
    31201 attgaggttc aaatcctagg tgatgagcat ggacatgtga ttcacttggg tgagcgggat
    31261 tgttctcttc aaaggaataa ccaaaaggtt ttggaagaaa gtccctcgat tgcaatcgga
    31321 aaaacgctgc gtcatgaaat aggtgctgct gctgttcgag cggcagagtt tgttggctat
    31381 gagaatgcag gaaccattga atttcttctt gatgaagcaa gtagcaattt ctatttcatg
    31441 gagatgaata ctcgtgttca ggtagaacat ccagtaacag agtttgtttc aggtgttgat
    31501 atcgttaagg aacagatttg cattgcggca ggtcagcctt tgtctgttaa gcaagaagat
    31561 attgtcctac gcggtcatgc catcgagtgt cgtatcaatg cagaaaaccc agcctttaac
    31621 tttgctccaa gtccaggtaa gattactaat ctctatctgc caagtggtgg agttggcttg
    31681 cgcgtggatt cagcagttta tccaggttat accattccgc cttattatga tagtatgatt
    31741 gccaaaatca tagtacacgg cgaaaatcgt tttgacgcct tgatgaaaat gcaacgtgcc
    31801 ctctatgaat tagagattga aggagtgcag accaatgcag atttccagct tgacctcatt
    31861 tcagatcgca atgtcattgc tggggattat gatacttcct tcttgatgga aaccttctta
    31921 cctaaatatc aagaaaaaga ataaaatgac tttaagagtt taaaccgaaa aggggaatca
    31981 atggctctat ttagtaaaaa agataagtat attcgaatca atcccaatcg ttcggttagg
    32041 gaaaaacctc aagctaagcc agaggttcca gatgaattat tttcccagtg tccaggctgt
    32101 aagcatacca tctatcagaa ggatctggga agtgaacgta tctgtccgca ctgtagctat
    32161 acctttcgta tttctgccca agaacgcttg gctttgacga ttgatatggg aaccttcaaa
    32221 gaattgttta cagggattga aagcaaggat cccttgcatt tccctggtta ccaaaagaaa
    32281 ctggcatcta tgcgtgaaaa aacaggtctg catgaagccg ttgtgacagg aactgctctt
    32341 attaaaggtc agactgtggc tcttgggatt atggattcta actttatcat ggcttctatg
    32401 ggtacggttg taggtgaaaa aatcactcgt ttgtttgagt atgcgactgt cgaaaaattg
    32461 ccagttgtcc tattcacagc ctctggtgga gcccgtatgc aggaaggaat catgagtctc
    32521 atgcagatgg ctaagatctc tgcggcggtt aaacgtcatt caaatgctgg tctcttttac
    32581 ctgaccattt tgacagatcc aacgactggt ggtgtgacag cttctttcgc tatggaaggc
    32641 gatatcattc tggctgaacc acagagcttg gttggttttg ctgggcgtcg tgtgattgaa
    32701 aatacggttc gtgaaagctt gcctgaggat ttccaaaagg cagaattcct attagaacat
    32761 ggctttgtgg atgctattgt caaaagaaga gacttaccag atacgattgc tagcctagtc
    32821 agattgcatg gagggagtcc tagatgaata ttgcaaaaat agtcagagaa gcgcgtgagc
    32881 agagtcgctt gacaaccttg gactttgcga caggcatttt tgatgaattt atccaattac
    32941 atggtgaccg ttcttttcgt gatgatggtg cagttgttgg tggtattggt tggcttggag
    33001 accaagctgt aacagttgtt ggtatccaaa aaggcaagag tttgcaagac aacctcaaac
    33061 ggaattttgg ccaaccacat ccagaaggct accgaaaggc actgcggttg atgaaacagg
    33121 ctgagaaatt tggccgtcca gttgtgacct ttattaatac agcaggtgct tatcctggtg
    33181 tcggagcaga agaacgtggt caaggggaag ctatcgctcg caatctcatg gaaatgagtg
    33241 acctgaaagt tcctattatc gccattatta tcggtgaagg tggttcaggc ggggctctgg
    33301 ctctagctgt cgcggaccgt gtctggatgc tggaaaattc tatctatgcc attctcagtc
    33361 cagaaggctt tgcttccatt ttatggaagg acggtactcg cgccatggaa gcagcagaac
    33421 tgatgaaaat cacttcgcat gaactgttag aaatggacgt ggtggataag gtgatttctg
    33481 aaataggact ttctagtaaa gaactgatta agagtgtcaa aaaagaactc caaacggagc
    33541 tggctagact ttcacaaaaa ccgctagaag agttgctgga agaacgctat caacgattta
    33601 gaaaatacta agaatgacta aatgagacta gaaaggtctc attttttatg gaaaaatgta
    33661 attcaggtcg aaaaattgcc agttgaggag atgggctata aaatagacaa aaaaagaaat
    33721 atactataaa tgtgagccta caacaatcta ttttaagaag gtacttgcaa tgacaggtac
    33781 aaatacattt acagttcttt caactgagga cttggagcaa acttcaggtg gtcttgctgt
    33841 ttgggaagat ggatatagta gatggttata ttatagagaa tttgctccct atatgaggca
    33901 aggggcactt aattcttata tagatgcttg gaagtacggc ttccgagcag ggtaatcttt
    33961 caaaaaagta cgatgagaaa cacaaaaaaa ctaagacaat ttggaatatt tttgcttatt
    34021 attttactat ctacctattt accacaaaca attggattgt atgtgacgat cattttaggg
    34081 ttaggagctg atgtctattc tcttatttta acaatgggat tagtgggaag tttccttcta
    34141 ttaatttgga ggttaaaaaa gaaaaagatg ctctttatct ttgagaaaaa gagctggaac
    34201 tggtcatttg tcttctactt atttgcaact tatgtggttt atcagattct cggtaatttt
    34261 tgggcacgct atgctcattt gattaatcat aggaatattc atgatgagta ttttaccgtg
    34321 cttttttcaa atggacaacc aaccttttta tcgactatct tatcttttgt cctgcctgta
    34381 atcatcggtc ctgtttttga ggagactctt gatagagggt attttatgaa taccttcttt
    34441 ccctagtcca agtactattt ggatgttatc ctatctgcta tcatctttgg gattagccat
    34501 ttgatactat ctcacagaga tccaattagt ttattatatt atagtctgat tggtttcttt
    34561 tttgcccttg tttatcgttc taccgacaat ctgagattaa cgattctctg ccatagtttt
    34621 tttaactttc tcaatcatgc aaaacctatc tggatttttg tttacaatta tatctattat
    34681 cattttttta gatagtggga ggcaaagaaa aaagtgtttg atatctatca aacacttttt
    34741 ctttttattg ttcttctgtt acaaactggc tgagcagtcc attgataaaa cgggcagatt
    34801 tttgatcgga gaagtccttt gcaagctcga tagcttcatt aacagcaacc agctgaggag
    34861 tgtcaaatga agtgatttca aagactccca agcgaaggag gtttctctcc acgagcgtta
    34921 agcgttcaat ggtccaacct gcttttaaat gctgagtgat ttgcttatct agttcttcct
    34981 ttttagcttg aacaccagaa acgaggtcta tcaaaaaggc tggaagttgt acatccgtat
    35041 cttcacgatc atgagtatag gcgaaacgac aagcagtttc gacatccgta ccgaactcaa
    35101 ggctcatgag agcttgaaaa gcgcatttac ggagttggcg tctagattct aatagtggac
    35161 tagtcattga ggaagtcctc gtcaaataga tctttcaatt ctggttttgg tgttttatct
    35221 gggacgatac ctgcaacgtg aatattgata gcagcgagtt ctacatcagc catattacgg
    35281 acggcatctt tgacagcttt ctggatagca accgctacct taggaacttt tactccgtac
    35341 tcaaggtaga gatagatatc tgctgtgagt tcttcgtcca cgtttttaag ataaatgcca
    35401 cggccgagtg aaagttttga aagggtatca gacactgatc tgtttgaaaa agagtgaaca
    35461 ccctctacct ttgcagtagc gatagcaatg attttttcaa gtacacgtgg ggcgataacg
    35521 atttcgccaa gttgttcttc aattcccata gaatgacctc tttctagaga ttaggcacga
    35581 gaaacgtaag ttccttctgc agtgttgata acgagttttt gtcctgcttc gatgaagtct
    35641 ggaacgttta cgacaagtcc agtttccatc gttgctggtt taccagaacc tgtaacagta
    35701 gcacctttga tagatggttg agtttcagca actgtcaact caacagtagt aggaacggtg
    35761 acaccgatca cttcagttcc gtagaattgg attttcacat cagagttttc aaggatgtaa
    35821 agcaattcgt tttcaacatt gactacaggg atttcgtatt ggtcgtaagt ttctgtattc
    35881 atgaagtatg ctgtgtcatc cattttgtac aagtattgag ctgggacagt ctcgataata
    35941 gcttgttcaa atttttcctc tggacggtag cttgtgtcaa atgtagaacc agtacggaca
    36001 tcacgcaatt tcatacgcat gatcgtgttt cctttacctg gtttgtggtg actagcttcc
    36061 aaaacgcgaa tcaatttgcc gtcagctgtt tcaaaggtca taccagcttt taatttactt
    36121 gcttcaatca tgtttttacc tctttaataa atattattac tcttcatttt accataaaat
    36181 actctggaaa taaagccaaa atagttattg ggagttggta gagaagaaaa aaccaacctt
    36241 agggctggtt ttgttctgtc tagttttctt tcaacttcgc caattcctgt gcaagtagtt
    36301 taagggcaac ttgtgggttg gcttggcctt tggttgcctt cataaggaat cctgtaaagg
    36361 ccttgtcggc gttacgtttg cctgacttga agtcgacaac agcagcttcg ttatcggcaa
    36421 agacttggtg gatgattggg atcaagatag ctggatctga aatttgaacc atacctgctt
    36481 tttccacgta ttcacgcgcg ccaccgccat ttttagctag atggacaaag actttcttgg
    36541 caatcttaga tgaaatagta ccgtcttcga tgatggcaat catttcaacc aagttttctg
    36601 gtgtcaattc gatttgttcc agtgttttac cttcagcatt caagaactga gcgacttccc
    36661 cttggagcca gttagagact tgtttggcat caccatctag ggcaacagct ttttcaaaga
    36721 aatcagaagt gactttatta gcagtcaact gactagcatc gtagtctgat aaaccaaggt
    36781 cagatacata acgcgcacga cgttcttttg gaaactctgg caactcagtc cgcatttcct
    36841 caatccactc gtcagaaatt tcaaagaggg gtaggtctgg ttctgggaag tagcggtagt
    36901 ctgcagcccc ttccttgaca cgcatgagaa tggttgcttt attcgcttca tcgtaacggc
    36961 gtgtttcttg gcggatttga ccacctgagc gaagaatttc agcctggcgt tggacttcgt
    37021 attcaagacc tttacgaacg tttgagaagg agttgaggtt cttcaattca gtcttggtac
    37081 cgaatttttc ttgaccataa gggcgaaggg agatgttggc atccacacgc atagaacctt
    37141 cttccatctt aacgtcagaa atgccagcgt actggataac ttccttgagg gctgtcagat
    37201 aagcataggc ttcttcagga gaacgcatat ctgcctcaga tacaatctca atcaagggaa
    37261 ccccttggcg gttgaggtca acataagagt agccgtctgt accatgggtg tttttaccag
    37321 cgtcttcctc taggtgggca cgttcgatac cgattttctt ggtcgtaccg tcttctagtt
    37381 cgacttcaat ccagccatta tatccgattg gttcatcaaa ttgagaaatt tggtaggctt
    37441 tggggttatc aggatagaag tagttcttgc ggtcaaagtg catctttttg tggatgtcca
    37501 tgttgagggc aagagcagcc ttgattccgg catcgacaac ccctttattg agaactggca
    37561 gaactcctgg gaaagaccag tcaatcacgt tagtgttggc attttgatca tttccgaagt
    37621 gggcagaagt aggtgagaag atttttgaat tggtgttgag ctctacgtgg acttcaagtc
    37681 cgatgactgt ttcaaagttc attagttgtc acctccaaaa atcacgggtt gttgtttgtg
    37741 gtagtctgtt gttgcttcaa aagcagcagc agcttggtaa atggtttcct cagagtactt
    37801 gggaccaatc aattgcagac cgacaggtag accttgagag aatccagcag gaatcgaaat
    37861 tccagggaga cctgctaagt ttacaggtat ggtcaagagg tcagccaagt acatggcaac
    37921 tgggtcatgg ttgagtgagt ccaagtcata ggcaacactt ggagcagttg gacccaaaat
    37981 caaatcgtaa tccgcgaaga ctttttcgaa atcttgaatg atgagggtac ggacttgacc
    38041 agcctttttg tagtaggcat catagtaacc tgatgaaaga ctgaaagtac ccagcatgat
    38101 acgacgtttt acctcttcac caaaaccttg gcttcggctg tttacataga tttcatcaag
    38161 gttggttgca tcttctgcgc gatagccgta acggataccg tcgaagcgtt gcaagtttga
    38221 tgaagcttct gatgaagcga tgatgtagta tacggcaact ccgtatttag agtgaggaag
    38281 gctgacttct tcgacaatag cacccaattt ttcaaagtgt ttagcggcat ttagaatggt
    38341 ttccttaacc tctgggttaa ttccttcacc gaggtattcc ttaggcaaag cgattttcat
    38401 acccttgatg tcttggccga tttttgaagt aaagtcggcg atgcggacag gagcagaagt
    38461 agagtcttta gcatcttcgc tggcaatagc gttgagcaag agggcatttt ccttaacagt
    38521 aggagcaaaa ggtccaatct ggtctaatga gctaccaaag gcaatgagac cgaaacgtga
    38581 aactgttccg taggttggtt tgagaccaac gattccgttg aaggcagcag gttggcggat
    38641 ggaaccacca gtatcagaac caagtgacaa gcgaacttgt cctgaggcta cagctgcggc
    38701 agaaccactt gatgacccac caggaacctt gctgtggtcc caagcgtttt tagttgctcc
    38761 gtagtgtgaa gtttcacctg aaccacccat agcaaattcg tccatgttgg tctttccaac
    38821 gacaatcatg cccttggttt ttgcattggc aacagctgtc gcatcaaaga ttggctcata
    38881 gttgtagagc atttttgagg cagcagttgt gagaataccg tctgtagaga tgttatcctt
    38941 aacagcaagt ggaattcctg aaaggacatt gtcagcatca attccagctt catcaatggc
    39001 tttagcttga acaagagctt gctcctcagc gatggtgaca aatgaattga gggcttcctc
    39061 acgagacttg atattttcaa gtgttgcttg ggtcaattct gttgcagaaa tttccttaga
    39121 gacaaggaga ttgtgcaact cttcaatagt tttattgtta aaagtcatta ggcatctcct
    39181 ccatcgtcta ggatagctgg caccttgata tagtagttgt cttttttagg tacgttttta
    39241 aacaagcgat cacggtctgt tccttcttcg gccacatcag ggcggagtac agtcttgcgg
    39301 tcagccatag tcgtagtagg tgcgacacca gttgtgtcaa cttcgcccag caattcaacc
    39361 atgtcaacaa tcttagacaa ggtggtcgca aaggcagcag tttctttttc agagaatctt
    39421 aattttgaaa gattggcaac gtgtgttacc tcttcttgcg taattttcat cttgcatcct
    39481 ttcgtgaaat gatgattttt agtctgttct attttaccat attttcctat aaataaggga
    39541 gggggaagtg aaaagaaata gaaattgaaa aaaatgctaa aatccgatat aatggagtgt
    39601 tgaaaggaat ggtaaaatcc aatgtaaaaa tcattctcag ctattgaaac aagaaaaata
    39661 gagaatcaaa gaaagagaac ttatgaatat tcaagaagaa attaagaaac gtcgtacctt
    39721 tgccattatc tcccacccgg acgcggggaa aacaaccatc actgagcagt tactctactt
    39781 tgggggtgag attcgtgagg ctggtacggt aaaagggaag aaaacaggga cttttgctaa
    39841 atctgactgg atggatatcg agaagcaacg tgggatttct gttacttcat ctgttatgca
    39901 atttgactac gacggcaagc gcgtgaatat cttagacacg ccagggcacg aggacttctc
    39961 agaagatacc tatcgtacct tgatggcggt ggatgctgcg gtcatggtcg tggactctgc
    40021 caaggggatc gaggctcaaa ccaagaaatt gtttgaggtt gtgaaacatc gtggcattcc
    40081 agtctttacc tttatgaaca agctggaccg tgacggtcgt gagcctttgg atctcttgca
    40141 agaattggaa gaaatcttgg gcattgctag ctaccctatg aactggccta tcgggatggg
    40201 gaaagccttt gagggcttgt atgacctcta taaccaacgt ttagagcttt acaaagggga
    40261 tgagcgtttt gccagtctag aagacgggga caaactcttt ggtagcaatc ctttctacga
    40321 gcaagtcaag gatgacattg agcttttaaa tgaagccggg aatgagtttt cagaggaagc
    40381 tattctggct ggagaattga cgcctgtctt tttcggttca gccctgacaa actttggtgt
    40441 gcagaccttc cttgaaacct tcctcaagtt tgctccagaa ccacatggtc acaagaaaac
    40501 agacggtgaa attgtggatc cttatgacaa ggatttctca ggatttgtct ttaaaatcca
    40561 agccaacatg gaccctcgtc accgtgaccg tattgccttt gtccgtatcg tatctggcga
    40621 atttgagcgc ggcatgagtg tcaatctccc tcgtactggt aagggggcta aactgtctaa
    40681 tgttactcag tttatggcgg aaagtcgtga gaatgtgatc aatgccgtgg caggtgatat
    40741 tatcggggtt tacgataccg gtacttatca agttggggat accttgacag ttggtaaaaa
    40801 caagtttgaa tttgaaccac tgccaacctt tactcctgaa attttcatga aagtttctgc
    40861 taagaatgtt atgaagcaaa aatccttcca caaggggatt gagcaattgg tgcaagaagg
    40921 tgctattcag ctttataaga attaccaaac aggtgagtac atgctaggcg ctgtaggtca
    40981 actccagttt gaagtcttta aacaccgcat ggaaggtgag tacaatgcag aagtagttat
    41041 gaacccaatg ggtaaaaaga ccgttcgttg gatcaagcct gaggacttgg atgaacggat
    41101 gtcgtcaagt cgcaatatct tagccaaaga ccgttttgac caaccagtct ttctctttga
    41161 aaatgacttt gccctccgct ggtttgcgga caagtatcca gacgtagagt tagaggagaa
    41221 gatgtgactc agtaccaaca attggaacta aagttccaaa ttgttggacg ctagtcgcta
    41281 tttggcgaac tagctaactg ccttactaac tacgtttggc aaatgaaatc gatttgtaaa
    41341 actccgtgtc gtaatgtaaa aattgtaaac cgtaatggga cttcatctaa aatctccact
    41401 ggtatggttt tacgaacgaa tgggcgaaaa taatggttac gtagaaacat atgatgggaa
    41461 taaaaagaaa tgagataaag agtggaagaa gagaaaaaag cgattgtctt aggtgcagat
    41521 aatgcttata tggataaagt tgaaataaca ataaaatctc tttgtgttca tctattataa
    41581 tcttaagttt tatgttttta atgatgacct tccgcgagaa tggttccaat tgatggaaaa
    41641 aagactagag actttgaata gtgagattgt gaatgtttag attgacagta gtattctgaa
    41701 aggttatcgt ctcccctttg agggactttc atatgatgat ttttatacac ataattttaa
    41761 ttctggtgtt ctgttaatca acaatggcat gtggagagca gaaaatgtca cgcaagacct
    41821 gatttaagac acaaataaaa aatcttccaa ttcccttgca aaaaacaaga aagtgtgata
    41881 acatagtacg gtatgtggtg ctagcacatc cgctatatta gatctaatag gaggaaaaca
    41941 caatggctaa agtatgttac tttacaggtc gtaagactgt atcaggaaac aaccgttcac
    42001 acgcgatgaa ccaaacaaaa cgtgccgtaa aaccaaacct tcaaaaagtt actgttctta
    42061 tcgatggtaa acctaaaaaa gtttgggctt cagctcgtgc tttgaaatca ggtaaagttg
    42121 aacgcgttta ataataaaag caaaggagac cttagggtct tttttctttt attgtgggta
    42181 taacatcgtt tgaaaaatag agtaaatatc cgctgataca tcattctgct tttacacttg
    42241 ggctgaaata tgataaaata gagtatcaac tagttgaggt aaaaaggatg actgtaaaaa
    42301 ttaatacaaa agatggtcaa atcgaactaa cagatgaagt gattgcaacc gtcgtaggtg
    42361 gagcagcaac tgagattttt ggtgtggtcg gtatggctag taaaaatgcc ctcaaagata
    42421 atttccaagc cctgctaggt aaggaaaatt attctaaagg tgtcgtcgta aaggcagccg
    42481 aagatggcag tattgcagtt gatgtatata ccgtgttaag ctacggaaca aagattagtg
    42541 aagtgtcaaa aaacattcaa gagcgtgttg cctttagctt ggaaaaccag cttggaatta
    42601 ctgctcagac tgtaaatgtc tacattcaaa atatcaaagt tgtaggagaa taaccgtgtc
    42661 aaaaattact actagcttat ttcaagaaat ggtgcaggct gcatcaactc gcttgaataa
    42721 gcaagctgaa tatgtcaatt cattaaacgt ctttccagtt ccagatggag atactgggac
    42781 aaatatggga atgaccattg aaaatggtgc taaagaagtt gcagacaagc cagcttctac
    42841 agttggagaa gtagcgagca ttcttgccaa agggcttttg atgggtgcgc gtgggaactc
    42901 aggagtgatt acatctcagc ttttccgtgg attttcccaa gctatcaagg ataaagacga
    42961 gttaacaggt caagacttgg ctctggcctt ccaatcaggt gtggaagttg cctataaggc
    43021 agtgatgaaa cctgttgaag gaacgatttt gacagtttct cgtggagctg ctatcggtgc
    43081 taagaaaaaa gctgagcaaa cagatgacac tgttgaagtc atgcgcgcag ccttggaagg
    43141 tgctaaaaca gctctagcta aaacaccaga catgcttcca gtattgaaag aagttggcgt
    43201 tgtggactca ggtggtcaag gattggtctt catctacgaa ggtttccttt cagcccttac
    43261 tggcgaatat attgcatctg aggactttgt agcgactcct gctaacatga gtgagatgat
    43321 caatgtagag catcataagt ctgtagctgg tcacgtagcg actgaggaca tcacgtttgg
    43381 ttactgtact gaaatcatgg tagctcttaa gcaaggtcca acttatgcta aagattttga
    43441 ctacgatgaa ttccgtaact acttggatga gcttggggat tctctcctcg ttgttaacga
    43501 tgatgaaatt gtcaaagtcc atgttcatac agaagatcca ggacttgtta tgcaagaagg
    43561 tctcaaatat ggtagcttgg tcaaggtaaa agttgacaat atgcgtaacc aacacgaagc
    43621 acaggttgag aaagaagcta ctcaagttat caagtcggct gaagaaaaag agtatgcttt
    43681 gattgctgtg gtggctggta aaggtctagc agatatcttc tgttctcaag gcgtggatta
    43741 tgttatcgaa ggcggtcaaa ccatgaaccc ttcaacagaa gactttatca aggctgttga
    43801 acaggtcaat gcccgtaaca tcatcttctt gccaaacaac aagaacatct tcatggcagc
    43861 tcaatctgcg gcagaagttt tggagcaacc agcagtagtg gtagaggctc gcactcttcc
    43921 tcaaggtatg acaagtcttc ttgcctttga tccaagcaag tccattgaag aaaatcaaga
    43981 gcgtatgaca gctgctctta gcgatgtcgt tagcggaagc gtcacaacag ccgtgcgtga
    44041 tacaacgatc gatggcttag aaatccatga aaacgataat ctaggtatgg tggatggaaa
    44101 aattcttgtg tcaaaccctg atatgcacca aacattgact gaaaccttga aacatatgtt
    44161 ggatgaagac agtgaaatcg taaccttcta tgtcggtgaa gacggaagcg aagaacttgc
    44221 caatgaaatc gctcaagaaa tcgtagaaga attcgaagac gttgaagtcg agattcacca
    44281 aggtcaacaa cctgtttacc catacctatt tagtgtggaa taagattaat gggctctttg
    44341 tcaactgtag tgggttgaaa aaaaagctaa gctcgagaaa ggacaaattt cgttctttct
    44401 tttttgatat tcagggcgat aaaaatcctt tttttgaagt tttcaaagtt ccgaaaacca
    44461 aaggcattgc gcttgataag tttgatgaga ttattggtcg cttccaattt ggcgttagaa
    44521 tagtgtagtt gaagggcgtt gacgattttc tctttgtcct ttagaaaggt tttaaagaca
    44581 gtctgaaaaa gaggatgaac ctgcttaaga ttgtcctcaa tgagtccgaa aaatttctcc
    44641 ggttccttat tctgaaagtg aaaaagtaag agttgataga tctgatagtg gtgtttcaag
    44701 tcttctgaat agcttaaaat cttgtcaaga atttctttat ttgttaagtg catgcgaaaa
    44761 gtagggcgat aaaaacgttt atcgctcaat ttacgactat cctgttggat gagtttccag
    44821 taacgtttga tag
//
LOCUS       DBERMM010000014        42675 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.014, whole genome shotgun sequence.
ACCESSION   DBERMM010000014 DBERMM010000000
VERSION     DBERMM010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 42675)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42675)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42675
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.014"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..227
                     /locus_tag="ACL8AS_000978"
     CDS             <1..227
                     /locus_tag="ACL8AS_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HGS1228857.1"
                     /translation="SQEVYWKVRNIEAEAIRRNCERGAIFSGKIKYHEDSQFKGDHYV
                     ECYAVLDNTVIARDRITVPIDPLCGKDFIE"
     gene            472..1806
                     /gene="trmFO"
                     /locus_tag="ACL8AS_000979"
     CDS             472..1806
                     /gene="trmFO"
                     /locus_tag="ACL8AS_000979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HGS1228858.1"
                     /translation="MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHK
                     TDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGF
                     SQMVTEKVANHPLIEVVRDEITELPTDVITVIATGPLTSDALAEKIHALNDGDGFYFY
                     DAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSF
                     EKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQ
                     DNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQT
                     YRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEVIFPETTAIGSLAH
                     YITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV"
     gene            1890..2627
                     /gene="pyrH"
                     /locus_tag="ACL8AS_000980"
     CDS             1890..2627
                     /gene="pyrH"
                     /locus_tag="ACL8AS_000980"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0033862 - UMP kinase activity [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HGS1228859.1"
                     /translation="MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSL
                     GIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQ
                     TAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILM
                     AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNM
                     NQSGNIKRVVFGENIGTTVSNNIEEKE"
     gene            2636..3193
                     /gene="frr"
                     /locus_tag="ACL8AS_000981"
     CDS             2636..3193
                     /gene="frr"
                     /locus_tag="ACL8AS_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008135 - translation factor activity, RNA
                     binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HGS1228860.1"
                     /translation="MANVIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEY
                     YGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDLGITPANDGSVIRLVI
                     PALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKQEKAKEITEDELKTLEKDI
                     QKVTDDAVKHIDDMTANKEKELLEV"
     gene            3253..4107
                     /gene="cvfB"
                     /locus_tag="ACL8AS_000982"
     CDS             3253..4107
                     /gene="cvfB"
                     /locus_tag="ACL8AS_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding virulence regulatory protein CvfB"
                     /protein_id="HGS1228861.1"
                     /translation="MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDT
                     VKGFAYTDMKQKLRLTTLEVTATQDQFGWGRVTEVRKDLGVFVDTGLPDKEIVVSLDI
                     LPELKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQNWPAIVY
                     RLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSF
                     EMLENDAQMILTYLESNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQ
                     DQFGTELI"
     gene            4116..4331
                     /locus_tag="ACL8AS_000983"
     CDS             4116..4331
                     /locus_tag="ACL8AS_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YozE family protein"
                     /protein_id="HGS1228862.1"
                     /translation="MRKSFYTWLMTERNPKSNSPKAILADLAFEESAFPKHTDDFDEV
                     SRFLEEHASFSFNLGDFDSIWQEYLEH"
     gene            4417..5421
                     /locus_tag="ACL8AS_000984"
     CDS             4417..5421
                     /locus_tag="ACL8AS_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HGS1228863.1"
                     /translation="MKEHSIDIQLSHPDDLFHLFGSNERHLRLMEEELDVVIHARTEI
                     VQVLGEESACEEARQVIQALMVLVNRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEI
                     IKDNTGKPIRVKTLGQKLYVDSVKQHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKR
                     IILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKDQTTRLMEREIIEIAP
                     LAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFHSKMIVNGDISQIDLPRNVKSG
                     LIDAQEKLKNIYQIDFVHFSAKDVVRHPVVAQIIRAYEPAPVKKEESEELESQPLSEG
                     "
     gene            5529..6098
                     /locus_tag="ACL8AS_000985"
     CDS             5529..6098
                     /locus_tag="ACL8AS_000985"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1228864.1"
                     /translation="MESIFVKFAQYPSIETERLLLRPVTLDDAEAMFDYASDKGNTRY
                     TFPTNQSLEETKNNIAQFYLANPLGRWGIELKSNGQFIGTIDLHKIDSVLKKAAIGYI
                     INKKYWNQGLTTEANRAVIELAFEKIGMNKLTALHDKDNPASGKVMEKSGMRFSHAEP
                     YACMDQHEKDRIVTRVHYVLTKEDYFANK"
     gene            6166..6816
                     /locus_tag="ACL8AS_000986"
     CDS             6166..6816
                     /locus_tag="ACL8AS_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HGS1228865.1"
                     /translation="MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQ
                     AEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKGAVKSPGIYDLPVGSRVNDAVQK
                     AGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
                     SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD"
     gene            6800..9040
                     /locus_tag="ACL8AS_000987"
     CDS             6800..9040
                     /locus_tag="ACL8AS_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005215 - transporter activity [Evidence
                     IEA];
                     GO_process: GO:0009290 - DNA import into cell involved in
                     transformation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA internalization-related competence protein
                     ComEC/Rec2"
                     /protein_id="HGS1228866.1"
                     /translation="MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCL
                     FIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQNLADSVERVRILPDTIKVNGDSL
                     SFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
                     LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLL
                     GHLDTDFEEMNELYSSLGIIHLFALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPF
                     SLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIVMPNFFLTAGGVLSC
                     AYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDL
                     TFLPLLSILFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLI
                     SLALVYDLRKNIKKLTVLCLLITGLFLLTKHPLENEITMLDVGQGESIFLRDVTGKTI
                     LIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDKENVGDL
                     SEVTKAFHVGEILVSKDSLKQKEFVAELQTTQTKVRSMTVGENLPIFGSQLEVLSPRK
                     MGDGGHDDTLVLYGKFLDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSS
                     SPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGINSKVYRTDQQGAIRFKGLDSW
                     KIESVR"
     gene            9219..9407
                     /locus_tag="ACL8AS_000988"
     CDS             9219..9407
                     /locus_tag="ACL8AS_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228867.1"
                     /translation="MTATKSYKYDWNTVLEYSTNYHDHQYAWIPEWSRYYSYSEYKVG
                     GGWNYARYEVINYYTGGY"
     gene            9439..10026
                     /locus_tag="ACL8AS_000989"
     CDS             9439..10026
                     /locus_tag="ACL8AS_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000939891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1228868.1"
                     /translation="MLNLTHVTLKTRQVILQDADFTFKKGRIYGLLAINGSGKTTLFR
                     AMSKLLPLSSGHIAVPPSLFYYESVEWLDGNLSGMDYLRLIKNIWKSDLNLRDEIAYW
                     EMADYISLPIRKYSLGMKQRLVIAMYFLSQAKCWLMDEITNGLDEYYRQKFFDRLAQI
                     DRQEQLVLLSSHYKEELVDICDRVVTIHQGQIEEV"
     gene            10030..11211
                     /locus_tag="ACL8AS_000990"
     CDS             10030..11211
                     /locus_tag="ACL8AS_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228869.1"
                     /translation="MKDVSLFLLKKVFKSRLNWIILLLFASVLGVTFYLNSQTANSHS
                     LESRLESRIAANERAINENEEKLSQMSDTSSEEYQFAKNNLDVQKNLLTRKTEILTLL
                     KEGRWKEAYYLQWQDEEKNYEFVSNDPTASSGLKMGVDRERKIYQALYPLNIKAHTLE
                     FPTHGIDQIVWILEVIIPSLFVVAIIFMLTQLFAERYQNHLDTAHLYPVSKVTFAISS
                     LGVGVGYVTVLFIGICGFSFLVGSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFPG
                     LLLAFLAFIVIVEVVYLIAYFFKQKMPVLFLSLIGIVGLLFGIQTIQPLQRIAHLIPF
                     TYLRSVEILSGRLPKQIDNVNLNWSMGMVLLPCLIILLLVGILFIESWGSSRKKEVFK
                     V"
     misc_feature    11371..11502
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            11518..12048
                     /gene="infC"
                     /locus_tag="ACL8AS_000991"
     CDS             11518..12048
                     /gene="infC"
                     /locus_tag="ACL8AS_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003743 - translation initiation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HGS1228870.1"
                     /translation="MKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADN
                     ANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGD
                     FDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPATDKK"
     gene            12081..12281
                     /gene="rpmI"
                     /locus_tag="ACL8AS_000992"
     CDS             12081..12281
                     /gene="rpmI"
                     /locus_tag="ACL8AS_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HGS1228871.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHL
                     RKASMVHSGDYKRIKAMLTRLK"
     gene            12333..12692
                     /gene="rplT"
                     /locus_tag="ACL8AS_000993"
     CDS             12333..12692
                     /gene="rplT"
                     /locus_tag="ACL8AS_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HGS1228872.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVND
                     AVAFTALADAAKAKLGK"
     gene            12750..13130
                     /locus_tag="ACL8AS_000994"
     CDS             12750..13130
                     /locus_tag="ACL8AS_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HGS1228873.1"
                     /translation="MASKMLHTCLRVENLEKSIAFYQDAFGFKELRRRDFPDHAFTIV
                     YLGLEGDDYELELTYNYDHGPYVVGDGFAHIALSTPDLEALHQEHSAKGYEVTEPNGL
                     PGTTPNYYFVKDPDGYKVEVIREK"
     gene            13380..14180
                     /locus_tag="ACL8AS_000995"
     CDS             13380..14180
                     /locus_tag="ACL8AS_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HGS1228874.1"
                     /translation="MNLTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRA
                     GQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMG
                     PQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILK
                     TELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHP
                     RAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL"
     gene            14143..15129
                     /locus_tag="ACL8AS_000996"
     CDS             14143..15129
                     /locus_tag="ACL8AS_000996"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004152 - dihydroorotate dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HGS1228875.1"
                     /translation="MVLFSAQEQLYYKEKIMTTNRLQVSLPGLDLKNPIIPASGCFGF
                     GQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAE
                     KLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGL
                     LIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVG
                     MRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSAEAALEM
                     YLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR"
     gene            15171..17336
                     /gene="lytB"
                     /locus_tag="ACL8AS_000997"
     CDS             15171..17336
                     /gene="lytB"
                     /locus_tag="ACL8AS_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endo-beta-N-acetylglucosaminidase"
                     /protein_id="HGS1228876.1"
                     /translation="MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASD
                     GTWQGKQYLKEDGSQAANEWIFDTHYQSWFYIKADANYAENEWLKQGDDYFYLKSGGY
                     MAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWIYDSQYDAWFYIKA
                     DGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFY
                     IKENGNYADKEWIFENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKIAEKEWVYDS
                     HSQAWYYFKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYM
                     TANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFY
                     LKSDGKMAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSDGKWLGGKATNKNAA
                     YYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTEDLQ
                     ALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLYFDGFKLE
                     NPFLFKDLTEATNYSAEELDKVFSLLNINNSLLENKGATFKEAEEHYHINALYLLAHS
                     ALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILGATKWIKENYIDRGR
                     TFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKD"
     gene            complement(17397..19052)
                     /gene="pavA"
                     /locus_tag="ACL8AS_000998"
     CDS             complement(17397..19052)
                     /gene="pavA"
                     /locus_tag="ACL8AS_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094859469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rqc2 family fibronectin-binding protein PavA"
                     /protein_id="HGS1228877.1"
                     /translation="MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQ
                     SHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEI
                     TVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGS
                     TYIAPPSTKSLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEK
                     LSAFRNFFNQETKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQA
                     SELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILD
                     NYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVET
                     VLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQN
                     EELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQ
                     VDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS"
     gene            19157..19654
                     /gene="ybeY"
                     /locus_tag="ACL8AS_000999"
     CDS             19157..19654
                     /gene="ybeY"
                     /locus_tag="ACL8AS_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004540 - RNA nuclease activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HGS1228878.1"
                     /translation="MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVT
                     NERSHELNLEYRDTDRPTDVISLEYKPELEIAFDEEDLLENPELAEMMSEFDAYIGEL
                     FISIDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFGLQEEILTAY
                     GLTRQ"
     gene            19635..20030
                     /locus_tag="ACL8AS_001000"
     CDS             19635..20030
                     /locus_tag="ACL8AS_001000"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000378166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family protein"
                     /protein_id="HGS1228879.1"
                     /translation="MDSQDNKRKWKNRDLISSLEFAITGIFTAIKEERNMRKHAVTAL
                     VVILAGLVFQVSRIEWLFLLLSIFLVVAFEIINSAIENVVDLASHYHFSMLAKNAKDM
                     AAGAVLVVSLFAALTGALIFLPRIWDLLF"
     gene            20047..20946
                     /gene="era"
                     /locus_tag="ACL8AS_001001"
     CDS             20047..20946
                     /gene="era"
                     /locus_tag="ACL8AS_001001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HGS1228880.1"
                     /translation="MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKI
                     MGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGD
                     DMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
                     LVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMK
                     RDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWV
                     KVKKNWRDKKLDLADFGYNEREY"
     gene            20995..21819
                     /gene="mutM"
                     /locus_tag="ACL8AS_001002"
     CDS             20995..21819
                     /gene="mutM"
                     /locus_tag="ACL8AS_001002"
                     /EC_number="3.2.2.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001114577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008534 - oxidized purine nucleobase
                     lesion DNA N-glycosylase activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="HGS1228881.1"
                     /translation="MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRE
                     LPSQIIESMGRRGKYLLFCLTDKVLISHLRMEGKYFYYPDQVPERKHAHVFFRFEDGG
                     TLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQAALAKSKKPIKSH
                     LLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGS
                     TIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD"
     gene            21819..22424
                     /gene="coaE"
                     /locus_tag="ACL8AS_001003"
     CDS             21819..22424
                     /gene="coaE"
                     /locus_tag="ACL8AS_001003"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259526.1"
                     /note="Dephospho-CoA kinase (CoaE) performs the final step
                     in coenzyme A biosynthesis; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004140 - dephospho-CoA kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HGS1228882.1"
                     /translation="MGKIIGITGGIASGKSTVTNFLRQQGFQAVDADAVVHQLQKPGG
                     RLFEALVQHFGQEIILENGELNRPLLASLIFSNPEEQKWSKQIQGEIIREELATLREQ
                     LAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAA
                     QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD"
     gene            22411..23610
                     /locus_tag="ACL8AS_001004"
     CDS             22411..23610
                     /locus_tag="ACL8AS_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HGS1228883.1"
                     /translation="MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQ
                     VAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYW
                     LIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAE
                     LFGIRTIFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLF
                     LTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDK
                     VGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPK
                     AGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYQAVFYATSLCVAFSCLFNLIQFRT
                     LLKVKEI"
     gene            23610..23759
                     /gene="rpmG"
                     /locus_tag="ACL8AS_001005"
     CDS             23610..23759
                     /gene="rpmG"
                     /locus_tag="ACL8AS_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HGS1228884.1"
                     /translation="MRVKINLKCSSCDSINYLTSKNSKTHPDKIEVLKYCPKERKVTL
                     HLESK"
     gene            23799..24032
                     /gene="secG"
                     /locus_tag="ACL8AS_001006"
     CDS             23799..24032
                     /gene="secG"
                     /locus_tag="ACL8AS_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015136 - sialic acid transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0015739 - sialic acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HGS1228885.1"
                     /translation="MYNLLLTILLVLSVVIVIAIFMQPTKNQSSNVFDASSGDLFERS
                     KARGFEAVMQRLTGILVFFWLAIALALTVLSSR"
     gene            24134..26488
                     /gene="rnr"
                     /locus_tag="ACL8AS_001007"
     CDS             24134..26488
                     /gene="rnr"
                     /locus_tag="ACL8AS_001007"
                     /EC_number="3.1.13.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HGS1228886.1"
                     /translation="MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMER
                     KHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAI
                     DGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
                     KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVL
                     ESMDIVSEFPEAVVKEAESVPDAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIK
                     ALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVVPMLPERLSNGICSL
                     NPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHK
                     IVPSIELMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIE
                     SFMLMANETVAEHFSKLDLPFIYRIHEEPKAEKVQKFIDYASSFGLRIYGTASEISQE
                     ALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSPIRRYPD
                     LLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYV
                     GEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVG
                     QQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSHSGRGRGSNRRSDKKEDKRKS
                     GRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK"
     gene            26451..26918
                     /gene="smpB"
                     /locus_tag="ACL8AS_001008"
     CDS             26451..26918
                     /gene="smpB"
                     /locus_tag="ACL8AS_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HGS1228887.1"
                     /translation="MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARI
                     NLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLHKKQIQKLEQETKGTG
                     MTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR"
     gene            26934..27794
                     /gene="tehB"
                     /locus_tag="ACL8AS_001009"
     CDS             26934..27794
                     /gene="tehB"
                     /locus_tag="ACL8AS_001009"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0046690 - response to tellurium ion
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase TehB"
                     /protein_id="HGS1228888.1"
                     /translation="MEKLVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGALK
                     FIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKY
                     NTNPVHSEVLEAMQTVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSI
                     VEQEDLDMPVGLYDINSASIEQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYN
                     LIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLR
                     FATLLAKKIK"
     gene            27867..28820
                     /gene="coiA"
                     /locus_tag="ACL8AS_001010"
     CDS             27867..28820
                     /gene="coiA"
                     /locus_tag="ACL8AS_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein CoiA"
                     /protein_id="HGS1228889.1"
                     /translation="MFVARDARGELVNVLEDKLEKQAYTCPACGGQIHLRQGPSVRTH
                     FAHKFLKDCDFFFENESPEHLANKESLYHWLKKETKVQLEYPLSELKQIADVFVNGNL
                     ALEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
                     YVWELDKEKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKKQKISHFTV
                     SEDKDICRYIRQQLYYQNLFWMKEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIE
                     QDLTSYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVE"
     gene            28839..30641
                     /gene="pepF"
                     /locus_tag="ACL8AS_001011"
     CDS             28839..30641
                     /gene="pepF"
                     /locus_tag="ACL8AS_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HGS1228890.1"
                     /translation="MVLQRNEINEKDTWDLSTIYPTDQAWEEALKDLTEQLETVVQYE
                     GHLLDSADNLLEITEFSLEMERQMEKLYVYAHMKNDQDTREAKYQEYYAKAMTLYSQL
                     DQAFSFYEPEFMEISEKQYADFLEAQPKLQVYQHYFDKLLQGKDHVLSQREKELLAGA
                     GEIFGSASETFAILDNADIVFPYVLDDDGKEVQLSHGTYTRLMESKKREVRRGAYQAL
                     YATYEQFQHTYAKTLQTNVKVQNYRAKVRNYKSARHAALAANFVPESVYDNLVAAVRK
                     HLPLLHRYLELRSKILGISDLKMYDVYTPLSSVEYSFTYQEALKKAEDALAVLGEDYL
                     SRVKRAFSERWIDVYENQGKRSGAYSGGSYDTNAFMLLNWQDNLDNLFTLVHETGHSM
                     HSSYTRETQPYVYGDYSIFLAEIASTTNENILTEKLLEEVEDDATRFAILNNFLDGFR
                     GTVFRQTQFAEFEHAIHQADQNGEVLTSDFLNKLYADLNQEYYGLSKEDNPEIQYEWA
                     RIPHFYYNYYVYQYSTGFAAASALAEKIVHGSQEDRDRYIDYLKAGKSDYPLNVMRKA
                     GVDMEKEDYLNDAFAVFERRLNEFEALVEKLGLA"
     gene            30643..31356
                     /locus_tag="ACL8AS_001012"
     CDS             30643..31356
                     /locus_tag="ACL8AS_001012"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HGS1228891.1"
                     /translation="MVESYSKNANHNMRRPVVKEEIVDLMRQRQKQVTGFLKELEDFA
                     RKENIPIIPHETVAYFRFLMETMQPKNILEIGTAIGFSALLMAEHAPNAKITTIDRNP
                     EMIGFAKENFAQFDSRKQITLLEGDAVDVLSTLTESYDFVFMDSAKSKYIVFLPEILK
                     HLEVGGVVVLDDIFQGGDVAKDIMEVRRGQRTIYRGLQRLFDATLDNSELTATLVPLG
                     DGILMLRKNVADVQLPDSE"
     gene            31423..32364
                     /gene="prsA"
                     /locus_tag="ACL8AS_001013"
     CDS             31423..32364
                     /gene="prsA"
                     /locus_tag="ACL8AS_001013"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HGS1228892.1"
                     /translation="MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFY
                     EQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAG
                     MTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAK
                     EVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGV
                     SDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIG
                     KELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE"
     gene            complement(32481..32822)
                     /locus_tag="ACL8AS_001014"
                     /pseudo
     CDS             complement(32481..32822)
                     /locus_tag="ACL8AS_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            33235..33330
                     /locus_tag="ACL8AS_001015"
                     /pseudo
     CDS             33235..33330
                     /locus_tag="ACL8AS_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            complement(33583..34203)
                     /locus_tag="ACL8AS_001016"
     CDS             complement(33583..34203)
                     /locus_tag="ACL8AS_001016"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HGS1228893.1"
                     /translation="MKLYFVRHGRTLWNQEGRFQGASGDSPLLPESIETLKRLGQYLK
                     EIPFDQIYSSDLPRAVKSAEIIQSQLYTPCSLEIVPNLREWQLGKLEGLKIATLEAIY
                     PQQIQAFRSNLAQFDTRMFGAESLYSTTQRTIQFIKSLKDSPAERILIVGHGANLTAS
                     LRTLLGYKEPLLRKDGGLANASLTIIETHDFETFTLNTWNDTSYQS"
     gene            complement(34203..34685)
                     /locus_tag="ACL8AS_001017"
     CDS             complement(34203..34685)
                     /locus_tag="ACL8AS_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA deacylase"
                     /protein_id="HGS1228894.1"
                     /translation="MAKKVKIKKTLVEQILSKAAIPHQGIQINALEGELPQGYERDQI
                     FKTLALLGDKTGPIIGIVPITQHLSEKKLAKISGNKKVSMIPQKDLEKTTGYIHGANN
                     PVGIRQKHNYPIFIDKIALDLDQMIVSAGEVGHSIIVAPQDLASFVKADFVDILEDIK
                     "
     gene            complement(34685..35527)
                     /locus_tag="ACL8AS_001018"
     CDS             complement(34685..35527)
                     /locus_tag="ACL8AS_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF368 domain-containing protein"
                     /protein_id="HGS1228895.1"
                     /translation="MLSWLARVIKGIVIALGFILPGISGGVLAAILGIYERMIGFLAH
                     PFKDFKENVLYFIPVAIGMLLGIGLFSYPIEYLLENYQVFVLWSFAGAIIGTVPSLLK
                     ESTRESDRDKIDLAWLWTTFIISGLGLYALNFVVGTLSASFLNFVLAGALLALGVLVP
                     GLSPSNLLLILGLYAPMLTGFKTFDFLGTFFPIGIGAGATLIVFSKLMDYALNNYHSR
                     VYHFIIGIVLSSTLLILIPNAGNAESIQYTGLSLVGYVIIAFFFALGIWLGIWMSQLE
                     DKYK"
     gene            complement(35622..36410)
                     /locus_tag="ACL8AS_001019"
     CDS             complement(35622..36410)
                     /locus_tag="ACL8AS_001019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 25 protein"
                     /protein_id="HGS1228896.1"
                     /translation="MRKQIHPLILFSFFGIMMFILIINRPLNDSQSFKTKSNIAQALK
                     HLDKPIIDLSGWQRPEEINYDALSQNISGAIVRVHSGAQTTKENDASFINGIDKAYKS
                     HITELQKRNVPVAVYAYVAGKSVQEMEKAAEVFYNAASPYSPSYYWLDVEDKTMSNMN
                     EGVENFRAKLASLGAKNIGIYVGVYFMEEHSIDTGKFTSVWIPSYGSDSGFLESSPKT
                     DLDYDIHQYTSKGKIAGFDHDLDINVISPLKNKEETFRKLFLKP"
     gene            36554..37933
                     /gene="glmU"
                     /locus_tag="ACL8AS_001020"
     CDS             36554..37933
                     /gene="glmU"
                     /locus_tag="ACL8AS_001020"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002899862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0003977 - UDP-N-acetylglucosamine
                     diphosphorylase activity [Evidence IEA];
                     GO_function: GO:0019134 - glucosamine-1-phosphate
                     N-acetyltransferase activity [Evidence IEA];
                     GO_process: GO:0006048 - UDP-N-acetylglucosamine
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HGS1228897.1"
                     /translation="MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQ
                     PEKTVTVVGHKAELVEEVLTGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGD
                     TPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATD
                     FEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLK
                     DFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVNPEATYIDIDVEIAPEVQIEA
                     NVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVTVGPYAHIRPN
                     SSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKY
                     KTVIGDNVFVGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYAT
                     RLPHHPKNQ"
     gene            37943..38488
                     /locus_tag="ACL8AS_001021"
     CDS             37943..38488
                     /locus_tag="ACL8AS_001021"
                     /EC_number="3.6.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HGS1228898.1"
                     /translation="MEFEEKTLSRKEIYQGPIFKLVQDQVELPEGKGTAQRDLIFHNG
                     AVCVLAVTDEQKLILVKQYRKAIEAVSYEIPAGKLEVGENTAPVAAALRELEEETAYT
                     GKLELLYDFYSAIGFCNEKLKLYLASDLTKVENPRPQDEDETLEVLEVSLEEAKELIQ
                     SGHICDAKTIMAVQYWELQKK"
     gene            38500..38814
                     /gene="macP"
                     /locus_tag="ACL8AS_001022"
     CDS             38500..38814
                     /gene="macP"
                     /locus_tag="ACL8AS_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall synthase accessory phosphoprotein
                     MacP"
                     /protein_id="HGS1228899.1"
                     /translation="MGKSLLTDEMIERANRGEKISGPPLLDDNEETKILPTSSSRFGY
                     ANPKDHGFSQETLKIQVEPSIHKSRRIENTKRNVFNSKLNKILFAVIFLLILLVLAMK
                     LL"
     gene            38831..39523
                     /locus_tag="ACL8AS_001023"
     CDS             38831..39523
                     /locus_tag="ACL8AS_001023"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008782 - adenosylhomocysteine
                     nucleosidase activity [Evidence IEA];
                     GO_function: GO:0008930 - methylthioadenosine nucleosidase
                     activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009164 - nucleoside catabolic process
                     [Evidence IEA];
                     GO_process: GO:0019509 - L-methionine salvage from
                     methylthioadenosine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HGS1228900.1"
                     /translation="MKIGIIAAMPEELAYLVQHLDNAQEQVVLGNTYHTGTIASHEVV
                     LVESGIGKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDV
                     TAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHFGLIATGDSFVAGNDKIEA
                     IKSHFPEVLAVEMEGAAIAQAAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRS
                     AQVLLTFLKALD"
     gene            39600..40091
                     /gene="rocS"
                     /locus_tag="ACL8AS_001024"
     CDS             39600..40091
                     /gene="rocS"
                     /locus_tag="ACL8AS_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein RocS"
                     /protein_id="HGS1228901.1"
                     /translation="MSIEMTVSEIAEVLGLSRQAINNRVKELPEEDTDKNDKGVTVVT
                     RSGLIKLEEIYKKTIFEDEPVSEDVKQRELMEILVDEKNAEILRLYEQLKAKDRQLSE
                     KDEQMRIKDRQIAEKDKQLDQQQQLTLQAMKDQENLKLELDQAKEEVQSTKKGFFARL
                     FGG"
     gene            40189..40779
                     /locus_tag="ACL8AS_001025"
     CDS             40189..40779
                     /locus_tag="ACL8AS_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HGS1228902.1"
                     /translation="MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYV
                     HTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAE
                     YGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
                     VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD"
     gene            40788..42551
                     /locus_tag="ACL8AS_001026"
     CDS             40788..42551
                     /locus_tag="ACL8AS_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphoryl diester phosphodiesterase
                     membrane domain-containing protein"
                     /protein_id="HGS1228903.1"
                     /translation="MKPEKPKKLGLKQIYLNLDKILFLFFLIFMIVEYLWVPFNSWLA
                     SFLLDQTGYLFISYNNVLAILTHSPLISLAFLALIVINLLVAYFQIGLLFIGARHLLY
                     NEKRRLIEYIRKVFHESFGFMKKLTCAKALFIFFYIAMLFPFIRKMLKIYYLNKIVIP
                     EFIQAYLEDKYWMWWLSILLLSLIFLYVSVRLMFALPKIVYDQLTVREAVMFSLEKTK
                     KRVTFYAWNLFYILLKAHLLFYLPLIPLLLAQTLVDDITQRESLILGILNFVVIKNLY
                     YMALTYFLVKFVSFLTGKELDMLPRREKDHIVRWGVMTCASLFFALEGYIYLEAPMVH
                     LPQLISHRGVSNANGIQNTVESLETTAQLKPDLVETDVQETKDGQFVMMHDANLKNLA
                     GINKSPQDLNLEELKGIDIFENGYQTKISSFEDYLSRANELGQKLLIEIKTSKKDSPD
                     MMNRFLARYAAKLKIYGHQIQSLDYHVVEKVRQYDAELPVYFIMPYNSVFPKTRATGY
                     TMEYSTLDEYFVSKLWTTDQKLYVWTVNDSEAISKSLHLGVDGVITDDLEKVQREIEV
                     AQEDPEYTDLLLKKALEFFEF"
BASE COUNT        12944 a         7791 c         9491 g        12449 t
ORIGIN      
        1 tttcgcagga agtctattgg aaagtaagaa atattgaagc tgaggctatt agaagaaatt
       61 gtgagcgtgg tgctattttt tcaggtaaaa taaaatatca cgaagattca cagtttaaag
      121 gagatcacta tgttgaatgt tatgctgttt tagataatac ggttatagca agagatagaa
      181 taacagtccc tatcgatccg ttatgtggaa aagattttat agagtagcat ataattgatt
      241 cttaactgga atactcacta tctctttaca tcaagaaaat gactaaacag ggaagtttgc
      301 cttcttccct ttttttgtta tactagtaga agaaaaaata gaaagatttg tgggagtgaa
      361 aaagtcctgt ggactttttc agcctgagcc aagaaactcg aaagcttgta agtctgattg
      421 gctttttcaa tgtgaatctt aacttcacac tcccaaagag gtattagtgt cgtgtctcaa
      481 tcttatatca atgttatcgg tgctggtttg gcaggttctg aagcagctta ccaaatcgca
      541 gagcgtggta ttccagttaa actatatgaa atgcgtggtg tcaagtctac accccagcat
      601 aaaacagaca attttgctga gttggtttgt tccaattctt tgcgtgggga tgctttgaca
      661 aatgcagttg gtcttctcaa ggaagaaatg cgtcgcttgg gttctgttat cttggaatct
      721 gctgaggcta cacgtgttcc tgccggtgga gcccttgcgg tggatcgtga tggtttctct
      781 caaatggtga ccgaaaaagt tgccaaccac cccttgattg aagtggttcg tgatgaaatt
      841 acagaattgc cgacagatgt tattacggtt atcgctactg gtcctttgac aagtgatgcc
      901 ttggctgaaa agattcatgc ccttaatgac ggtgatggtt tttatttcta cgatgcggca
      961 gcgcctatta tcgatgtcaa cactatcgat atgagcaagg tctacctcaa atcacgttat
     1021 gataagggag aagcggccta cctcaatgcc cctatgacca agcaagaatt tatggatttc
     1081 catgaagctt tggtcaatgc agaagaagca ccgcttaatt cttttgaaaa agaaaagtac
     1141 tttgaaggat gtatgcctat cgaagttatg gccaaacgtg gcattaaaac tatgctttat
     1201 ggccctatga agccagtcgg tcttgagtat ccggacgact acacaggacc tcgtgatgga
     1261 gaatttaaaa caccttatgc ggttgtgcaa cttcgtcagg ataatgcagc tggtagcctc
     1321 tacaatatcg ttggtttcca gacccacctc aaatggggag aacaaaagcg tgtcttccaa
     1381 atgattccgg gtcttgaaaa tgcggagttt gtccgttatg gtgtcatgca tcgcaattct
     1441 tacatggatt caccaaatct tcttgagcag acttaccgtt ccaagaaaca accaaatctc
     1501 ttctttgctg gtcagatgac gggggtggaa ggctatgttg agtcggcggc ttcgggctta
     1561 gttgcgggaa ttaacgcagc tcgtctcttc aaggaagaaa gcgaggttat tttccccgag
     1621 acgacagcga ttggaagctt agctcattac attacccatg ccgacagcaa acatttccaa
     1681 ccaatgaatg tcaattttgg gatcatcaag gagttggaag gcgagcgtat ccgtgataag
     1741 aaggctcgtt atgaaaaaat tgcagagcgt gcccttgccg acttagagga atttttgact
     1801 gtctaatttt tttgaaagaa ttgctcatga tactataaaa atcttagaaa ttgtgataaa
     1861 ataggtagga tgaaagaagg agagtgaaaa tggcgaatcc caagtataaa cgtattttaa
     1921 tcaagttatc aggtgaagcc cttgccggtg aacgtggcgt agggattgat atccaaacag
     1981 ttcaaacaat cgcaaaagag attcaagaag ttcatagctt aggtatcgaa attgcgcttg
     2041 ttattggtgg aggaaatctc tggcgtggag aacctgcagc agaagcaggt atggaccgtg
     2101 ttcaggcaga ttacactgga atgcttggga ctgttatgaa tgctcttgtg atggcagatt
     2161 cattgcaaca agttggggtt gatacgcgtg tacaaacagc tattgctatg caacaagtgg
     2221 cagagcctta tgtccgtgga cgtgcccttc gtcaccttga aaaaggccgt atcgttatct
     2281 ttggtgctgg aattggttca ccatacttct cgacagatac aacagcggcc cttcgtgcag
     2341 ctgaaatcga agcagatgcc atcctcatgg ctaaaaatgg cgtcgatggt gtgtacaatg
     2401 ccgatcctaa gaaggacaag acagccgtta agtttgaaga attgacccac cgtgatgtta
     2461 tcaacaaagg tcttcgtatc atggactcaa cagcctcaac cctctcaatg gacaacgaca
     2521 ttgacttggt tgtcttcaac atgaaccaat caggcaacat caaacgtgtc gtatttggtg
     2581 aaaatatcgg aacaacagtt tcaaataata tcgaagaaaa ggaataagaa agaatatggc
     2641 taacgtaatt attgaaaaag ctaaagagag aatgacccag tctcaccaat cacttgctcg
     2701 tgaatttggt ggtatccgtg ctggtcgtgc caatgcaagc ttgcttgacc gtgtacatgt
     2761 agaatactat ggagtcgaaa ctcctcttaa ccaaatcgct tcaattacga ttccagaagc
     2821 gcgtgttttg ttggtaacac catttgacaa gtcttcattg aaagacatcg aacgtgcctt
     2881 gaacgcttct gatcttggta tcacaccggc taatgacggt tctgtgattc gcttggttat
     2941 cccagctctt acagaagaaa ctcgtcgtga ccttgctaaa gaagtgaaga aggtcggcga
     3001 aaatgctaaa gtggctgtcc gcaatatccg tcgcgatgct atggacgaag ctaagaaaca
     3061 agaaaaagca aaagaaatca ctgaagacga attgaagact cttgaaaaag atattcaaaa
     3121 agtaacagac gatgctgtta aacacatcga cgatatgact gccaacaaag agaaagaact
     3181 tttggaagtc taaaaataaa cagaaaaact cagttggcat tgctggctga gttttattcg
     3241 aaagaaggaa atatgaatac aaatcttgca agttttatcg ttggactgat catcgatgaa
     3301 aacgaccgtt tttactttgt gcaaaaggat ggtcaaacct atgctcttgc taaggaagaa
     3361 ggccaacata cagtagggga tacggtcaaa ggttttgcat acacggatat gaagcaaaaa
     3421 ctccgcctga caaccttaga agtgactgcc actcaggacc aatttggttg gggacgtgtc
     3481 acagaggttc gtaaggactt gggtgtcttt gtggatacag gccttcctga caaggaaatc
     3541 gttgtgtcac tcgatattct ccctgagctc aaggaactct ggcctaagaa gggcgaccaa
     3601 ctctacatcc gtcttgaagt ggataagaaa gaccgtatct ggggtctctt ggcttatcaa
     3661 gaagacttcc aacgtcttgc tcgtcctgcc tacaacaaca tgcagaacca aaactggcca
     3721 gccattgttt accgtctcaa gctatcagga acttttgttt acctaccaga aaataatatg
     3781 cttggtttta ttcatcctag cgagcgttac gcagagccac gtttggggca agtattagat
     3841 gcgcgcgtta ttggtttccg tgaagtggac cgcactttga acctctccct caaaccacgc
     3901 tcctttgaaa tgttggaaaa cgatgctcag atgattttga cttatttgga aagcaatggc
     3961 ggtttcatga ccttaaatga caagtcatct ccagacgaca tcaaggcaac ctttggcatt
     4021 tctaaaggtc agttcaagaa agctttaggt ggtcttatga aggctggtaa aatcaagcag
     4081 gaccagtttg gtacagagtt gatttaggga ggcttatgag aaaatcattt tacacttggc
     4141 tcatgaccga gcgcaatcct aaaagtaaca gtcccaaagc aattttggca gacctcgctt
     4201 ttgaagagtc agcctttcca aaacatacag atgattttga tgaggtcagt cgctttttgg
     4261 aggagcatgc cagtttctct tttaacctag gagattttga cagcatttgg caggaatatc
     4321 tagaacacta gcatttattc attgggtttg ggctagtaat ttctccatcc ctctgctata
     4381 ataaaaagaa ataaaaggat tagagaggtt ctttatttga aggaacattc aatagacatt
     4441 caactgagtc atccagatga cctgtttcat ctttttggtt ccaatgaacg ccatcttcgt
     4501 ttgatggaag aagagcttga tgttgtgatt catgctcgta cggagattgt ccaggttttg
     4561 ggagaagagt ctgcctgtga ggaagcccgt caagttattc aggctttgat ggtcttggta
     4621 aatcgtggga tgaccgttgg tacgccagat gtagtcactg cgattagcat ggtcaaaaat
     4681 gatgaaattg acaagtttgt cgccctttac gaagaagaaa ttatcaaaga taatactggg
     4741 aaacctatcc gtgtcaaaac cctagggcaa aagctttatg tggacagtgt caaacagcat
     4801 gatgtgacct ttggaattgg gccagcaggt acagggaaga ccttccttgc agtgaccttg
     4861 gcagtgactg cccttaaacg tgggcaagtc aagcgaatta tcctaactcg tccagcggtg
     4921 gaagcgggag agagtcttgg atttcttccg ggtgatctta aggagaaggt ggatccttac
     4981 cttcgtcctg tttacgatgc cttgtatcaa attcttggga aagaccaaac gactcgtctc
     5041 atggagcgtg aaattatcga aattgcgccc cttgcctata tgcgtggtcg gaccttggat
     5101 gatgcctttg tcattctcga tgaggcgcaa aatacgacca tcatgcagat gaagatgttc
     5161 ttgactcgtt taggttttca ttctaagatg attgtcaatg gagatattag tcagattgat
     5221 ctgccacgta atgtcaagtc cggtttgatt gatgcccaag aaaagctcaa gaacatttac
     5281 caaattgact ttgttcattt ttcagctaag gatgtggttc gccatccagt tgtcgctcag
     5341 attatccgag cttatgaacc agctccagtt aaaaaagaag agagtgaaga attagagtct
     5401 caacctctgt ctgaaggata gttcttttgt acttaaagtt atctcaatgc taagtataaa
     5461 tttgcttttt aaatgtttta ttcaatatcc ttatattaga ttagaaacgt ttcaagcgga
     5521 ggaaacgtat ggaatcaata tttgtgaaat ttgcccagta tccgtctata gaaacggagc
     5581 gtttattgct tagacctgta actttggatg atgcggaagc aatgtttgac tatgcctcgg
     5641 acaagggtaa tacacgttac acttttccaa ccaatcaaag cttggaagaa accaagaata
     5701 acattgctca gttctatttg gctaatccct tgggacgttg gggaatagaa ctaaaaagca
     5761 atggtcagtt tattggaacc attgacttgc acaagattga ttctgttctt aagaaggcag
     5821 ctattggcta cattatcaat aaaaagtatt ggaatcaagg attaacgaca gaagccaatc
     5881 gtgctgtgat tgagctagct tttgagaaga tagggatgaa taagttgact gcccttcacg
     5941 ataaggacaa tcctgcgtca ggaaaggtca tggagaaatc aggcatgcgt ttttcccatg
     6001 cagaaccata tgcttgtatg gaccagcatg aaaaagatcg aatcgttaca agagttcatt
     6061 atgtcttgac caaggaagac tattttgcaa ataaataagc agttgaaaag aaatttttcg
     6121 actgtttttt cttcctctta cgaataatct aagagaggag aaaatatgga agcaattatc
     6181 gagaaaatca aagagtataa aatcatcgtc atctgtactg gtctgggctt gcttgtaggc
     6241 ggatttttcc tgctaaagcc agctccacaa acacctgtaa aggaaacgaa tttgcaggct
     6301 gaagttgcag ctgtttccaa ggatttggta tccgaaaagg aagtgaacaa ggaagagaag
     6361 gaagaaccag ttgaacaaga tctaatcaca gtagatgtca aaggtgctgt caaatcgcca
     6421 gggatttatg acttgcctgt aggtagtcga gtcaatgatg ctgttcagaa ggctggtggc
     6481 ttgacagagc aagcagacag caagtcgctc aatctagctc agaaagttag tgatgaggct
     6541 ctggtttacg ttcctactaa gggagaagaa gcagttagtc aacagactgg ttcggggaca
     6601 gcttcttcaa taagcaagga aaagaaggtc aatctcaaca aggccagtct ggaagaactc
     6661 aagcaggtca agggactggg aggaaaacga gctcaggaca ttatcgacca tcgtgaggca
     6721 aatggcaagt tcaagtcagt agacgagctc aagaaggtct ctggcattgg tggcaaaaca
     6781 atagaaaagc ttaaagacta tgttacagtg gattaagaat ttctctattc ccctaattta
     6841 cctgagtttt ctattacttt ggctttatta cgctattttc tcagcatctt atcttgcttt
     6901 gttgggcttt gtttttctgc tagtctgtct ctttatccaa tttccgtgga aatctgctgg
     6961 taaagttcta ataatttgcg gaatctttgg attttggttt gtttttcaaa attggcaaca
     7021 gagtcaagcg agtcaaaatc tggcggattc tgttgaaagg gtacggattt tgcctgatac
     7081 tattaaggtt aatggtgata gtctatcctt tcgtggcaag tctaacggtc gtgctttcca
     7141 agtctattat aaactccagt ccgaggagga gaaagaagcc tttcaagctt taaccgacct
     7201 gcatgagata ggactagaag ggaagctttc ggagccagaa gggcagagaa attttggtgg
     7261 ctttaattac caagcctatc tgaagactca gggaatttac cagactctca atatcaaaac
     7321 aatccagtca cttcaaaaga ttggcagttg ggatatagga gaaaacttgt ccagtttacg
     7381 tcgaaaggct gtggtttgga ttaagacgca ctttccagac cctatgcgca attacatgac
     7441 aggactcttg ctgggacatc tggacaccga ctttgaggag atgaatgagc tttattccag
     7501 tctaggaatt atccacctct ttgccctatc tggtatgcag gtaggttttt tcatgaatgg
     7561 atttaagaaa cttctcttgc gattgggctt gacccaagaa aagttgaaat ggctgactta
     7621 tcccttttcc cttatctatg cgggactaac tggattttca gcatcggtta ttcgcagtct
     7681 cttgcaaaag ctactggctc aacatggggt taagggcttg gataattttg ccttgacggt
     7741 gcttgtcctc tttattgtca tgccaaactt tttcttgaca gcaggaggag tcttgtcctg
     7801 cgcttatgct tttatcctga ccatgaccag caaagaaggg gaggggctca aggctgttac
     7861 tagtgaaagt ctagtcatct ccttgggcat attgcccatt ctatccttct attttgcgga
     7921 atttcaacct tggtctatcc ttttgacctt tgtcttttcc tttctatttg acttgacctt
     7981 cttaccgctc ttgtctattt tatttgtcct ttcctttctc tatccagtca ttcagctgaa
     8041 ctttatcttt gaatggttgg agggcattat tcgcttggtg tcacaggtga caagtagacc
     8101 tctggtcttt ggacaaccca atgcatggtt tttaatccta ttgttaattt ccttggcttt
     8161 ggtctatgat ttgagaaaaa acattaaaaa gctaacggta ttgtgcttat tgattacagg
     8221 gctctttctc ctgaccaagc atccactgga aaatgaaatc accatgctgg atgtggggca
     8281 aggagaaagt attttcctac gggatgtaac tgggaaaacc attctcatag atgtaggtgg
     8341 taaggcagaa tcttataaga aaatcgaaaa atggcaagaa aagatgacga ccagcaatgc
     8401 ccagcgaacc ttgattccct atctcaaaag tcgaggagta gctaagattg accagctaat
     8461 tttgactaac acggacaagg agaatgttgg agatttgtca gaggtgacca aggctttcca
     8521 tgtaggggag attctagtat caaaagacag tctgaaacag aaggaatttg tggcagaact
     8581 acagacgact caaacaaagg tgcgtagtat gacagtaggg gagaacttgc ccatttttgg
     8641 aagtcagtta gaagttctat ctccaaggaa aatgggagat ggaggacacg atgacaccct
     8701 agttctgtat gggaaattct tggataagca atttctcttc acgggaaatt tggaggagaa
     8761 aggagagaag gacttgctga agcactatcc agacttgaaa gtaaatgttt tgaaagctag
     8821 ccaacatggc aataaaaaat catcaagtcc agcctttcta gaaaaactca aaccagagct
     8881 tactcttatc tcagttggaa agagcaatcg aatgaaactc ccccatcagg aaacattgac
     8941 acgactggaa ggtatcaata gcaaagttta tcgaactgac cagcaaggag ctatacgttt
     9001 taaggggttg gatagttgga aaatcgaaag tgttcgatag gaaggataaa tgttgtagat
     9061 tagtgaaata aactaaaaat ttgttgcata ataatgataa aaatggtata atgaaaacgt
     9121 attcaatatt gaggatataa aatcattaaa aatcagcaaa agttgtttta ttagttagtt
     9181 tataatctat tggtcttctt cagtccagtg tatctgctgt gacagccact aaaagttaca
     9241 agtatgattg gaatacggtt ttggaatata gtaccaacta tcacgaccat cagtatgctt
     9301 ggattccgga atggtctcgt tattacagct attctgagta taaagttggc ggaggctgga
     9361 actacgctcg ttatgaggtc ataaactact atactggagg ttattaatcc ttaaagagtg
     9421 agaaaaggag ggctggatat gttaaatctt actcatgtta ccttaaaaac gcgacaagtc
     9481 atcttgcaag atgcggattt tacctttaaa aagggtagga tttatggcct tcttgctatc
     9541 aatggctcgg gaaagacgac actattccga gctatgagca agttgcttcc ccttagtagt
     9601 ggacacatcg cagttcctcc ttctttgttt tattatgaga gcgttgaatg gctggatgga
     9661 aacttaagtg ggatggacta ccttcgtctc ataaaaaaca tctggaagtc agacctaaac
     9721 ttgagagatg aaatcgccta ctgggaaatg gctgactata tcagtcttcc catccgcaag
     9781 tattccttag ggatgaagca acgcttggtg attgctatgt attttctcag tcaggccaaa
     9841 tgctggctca tggatgagat tacaaatggc ttagacgagt attatcgaca gaagtttttt
     9901 gataggctag cacaaatcga tagacaagaa cagctggttc ttttaagttc ccactataag
     9961 gaagagttgg ttgatatctg cgatagagta gtaaccattc atcaggggca gatagaagag
    10021 gtttagttta tgaaagatgt tagtctattt ttattgaaaa aagttttcaa aagtcgttta
    10081 aactggatta tcttactttt atttgcatct gtactcggtg ttacctttta tttaaatagt
    10141 cagactgcaa actcacacag cttggagagc aggttggaaa gtcgcattgc agccaacgag
    10201 agggctatca atgaaaatga agagaaactc tcccaaatgt ctgataccag ctcggaggaa
    10261 taccagtttg ctaaaaataa tttagacgtg caaaaaaatc ttttgacgcg aaagacagaa
    10321 attctaactt tactaaaaga agggcgctgg aaagaagcct actatctgca gtggcaagat
    10381 gaagagaaga attatgaatt tgtatcaaat gacccgactg ctagctctgg cttaaaaatg
    10441 ggggttgacc gcgaacggaa gatttaccaa gccctgtatc ccttgaacat aaaagcacat
    10501 actttggagt ttccgaccca cgggattgat cagattgtct ggattttaga ggttatcatc
    10561 ccaagcttgt ttgtggttgc gattattttt atgctaacac aactatttgc agaaagatat
    10621 caaaatcatc tggacacagc tcacttatat cctgtttcaa aagtgacatt tgcaatatcc
    10681 tctcttggag ttggagtggg atatgtaact gtgctgttta tcggaatctg tggcttttct
    10741 tttctagtgg gaagtctgat aagtggtttt ggacagttag attatcccta cccaatttat
    10801 agcttagtga atcaagaagt aactattggg aaaatacaag atgtattatt tcctggcttg
    10861 ctcttagctt tcttagcctt tatcgtcatt gtggaagttg tgtacttgat tgcttacttt
    10921 ttcaagcaaa aaatgcctgt cctctttctt tcactcattg ggattgttgg tttattgttt
    10981 ggcatccaaa ccattcagcc tcttcaaagg attgcacatc tgattccctt tacttacttg
    11041 cgttcagtgg agattttatc tggaagatta cctaagcaaa ttgataatgt caatctaaat
    11101 tggagcatgg ggatggtctt gcttccttgc ctgattatcc ttttgttagt ggggattcta
    11161 tttatcgaaa gctggggaag ttcacgtaaa aaggaagttt ttaaagttta gttttcctat
    11221 agggaagcta aagaaaaact aacataggga gagaatcaac ttggttctct ctttttgatt
    11281 cgaaaaccaa accaaaatac aaacacaaac ttttcaaaaa ataacttttt atcttgacaa
    11341 gagctagaaa acttggtatc atataaaagt tgagaaaagc agaagtgaga gcttctcgcc
    11401 ttgtgacatt aagttgcctg gccctacgga tgaaaagttt cgaagaaacg ctatcataac
    11461 gtgcgggctt gtatatttac aagtccgcta ttgtttttct ctaataaaac aaaagaggtg
    11521 aaaaccatag caaagcaaga cttattcatc aatgatgaga ttcgtgtacg tgaagttcgc
    11581 ttgattggtc ttgaaggaga acagctaggt atcaagccac tcagtgaagc gcaagctttg
    11641 gctgataacg ctaatgttga cctagtattg attcaacccc aagccaaacc gcctgttgca
    11701 aaaattatgg actacggtaa gttcaaattt gagtaccaga agaagcaaaa agaacaacgt
    11761 aaaaaacaaa gcgttgttac tgtgaaagaa gttcgtctaa gtccaacaat tgacaagggt
    11821 gactttgata caaaacttcg taatgcacgt aagttccttg aaaaaggaaa taaagttaag
    11881 gtatctattc gctttaaggg tcgtatgatt acccataaag agattggtgc aaaagtttta
    11941 gccgagtttg ctgaagcaac tcaagatatt gccatcatcg aacaacgtgc taaaatggat
    12001 ggacgtcaaa tgttcatgca attggcgcca gcgactgaca aaaaataatt gtcagaaagt
    12061 taaataaagg agaaaaaatc atgccaaaac aaaaaacaca ccgcgcatca gctaaacgtt
    12121 tcaaacgtac aggttctggt ggacttaaac gtttccgtgc ttacacttct caccgtttcc
    12181 acggaaaaac taagaaacaa cgtcgtcatc ttcgtaaagc atctatggtg cattcaggag
    12241 attacaaacg tatcaaagca atgcttactc gcttgaaata atagcttgac tgtaagtaaa
    12301 caattctagg aaatatttgg aggaaataaa acatggcacg tgttaaaggt ggcgttgtat
    12361 cacgcaaacg tcgtaaacgt attcttaaat tagcaaaagg ttactatgga gctaaacaca
    12421 tcttgttccg tactgcaaaa gaacaagtaa tgaactctta ctactatgca taccgtgacc
    12481 gtcgtcagaa aaaacgtgac ttccgcaaat tgtggattac tcgtatcaat gcggcagctc
    12541 gtatgaacgg actttcatac tcacaattga tgcatggttt gaaattggct gagattgaag
    12601 ttaaccgtaa aatgcttgct gacttggctg ttaacgatgc agtagctttc acagctcttg
    12661 cagatgcagc taaagcaaaa cttggtaaat aataactgat gagactggaa caggattgtc
    12721 cagtcttttt aaaaataaag gagaaagata tggcttcaaa aatgctacac acttgcttac
    12781 gagtagaaaa tcttgaaaaa tcaatcgcat tttatcaaga tgcttttggt tttaaagaat
    12841 tgcgtcgcag agattttcca gaccatgcct tcacgattgt ctatctaggt cttgagggtg
    12901 atgattatga gttggagttg acttataact acgatcacgg tccgtatgtg gttggtgatg
    12961 ggtttgccca tatcgccctc agtacacctg atcttgaggc acttcatcaa gaacacagtg
    13021 caaaaggcta tgaagtgact gagccaaatg gtctaccagg aactacacca aactattact
    13081 ttgttaaaga ccctgatgga tataaggtcg aagtcattcg tgaaaaataa tttcgtgcaa
    13141 gttaagtaga atattcgttt tctacttgac tttttttagc tgaaagagta tactaataaa
    13201 aattcaacct ttaaggggag tccagagaga ctcacaaggt gtcagataaa agaatagtgc
    13261 aattttctag aggagacctt ttgagtgtgc tctcttgtgt tgtacgattt taactgaggc
    13321 cttgcactag caaggtcttt tctttatctg gtccccttaa aatttaagga ggaaaagtta
    13381 tgaatctcac atgtaagaag cgtttgggtg tcattcggtt ggaaaccatg aaggtggttg
    13441 cacaagagga aatcgcgcca gcaatctttg aattagtcct agaaggagaa atggttgaag
    13501 ccatgcgagc aggccaattt cttcatctgc gtgtaccaga cgatgcccat ctcttacgtc
    13561 gtcctatttc aatttcgtct attgacaagg caaacaagca gtgtcacctc atttatcgga
    13621 ttgagggagc tgggactgca attttttcaa ccttaagtca gggagacact cttgatgtga
    13681 tggggcctca gggaaatggt tttgacttgt ctgaccttga tgagcagaat caggttctcc
    13741 ttgttggtgg tgggattggt gttccaccct tgcttgaggt ggccaaggaa ttgcatgaac
    13801 gtggagtgaa agtagtgaca gtcctcggtt ttgctaataa ggatgctgtt attttgaaaa
    13861 cggaattggc tcagtatggt caggtctttg taacgacaga tgatggttct tatggcatca
    13921 agggaaatgt ttccgttgtt atcaatgatt tagatagtca gtttgatgct gtttactcgt
    13981 gtggggctcc aggaatgatg aagtatatca atcaaacctt tgatgatcac ccaagagcct
    14041 atttatctct ggaatctcgt atggcttgtg ggatgggagc ttgctatgcc tgtgttctaa
    14101 aagtaccaga aagcgagacg gtcagccaac gcgtctgtga agatggtcct gttttccgca
    14161 caggaacagt tgtattataa ggagaaaatt atgactacaa atcgattaca agtgtctcta
    14221 cctggtttgg atttgaaaaa tccgattatt ccagcatcag gctgttttgg ctttggacaa
    14281 gagtatgcca agtactatga tttaaacctt ttaggttcta ttatgatcaa ggcgacaacc
    14341 cttgaaccac gttttgggaa cccaactcca agagtagcag agacgcctgc tggtatgctc
    14401 aatgcaattg gcttgcaaaa tcctggttta gaggttgttt tggctgaaaa gctaccttgg
    14461 ctggaaagag aatatccaaa tcttcctatt attgccaatg tagctggttt ttcaaaacaa
    14521 gagtatgcag ctgtttctca tgggatttcc aaggcaacta atgtaaaagc tatcgagctc
    14581 aatatttctt gtcccaatgt tgaccactgt aatcatggac ttttgattgg tcaagatcca
    14641 gatttggctt atgatgtggt gaaagcagct gtggaagcct cagaagtgcc agtttatgtc
    14701 aaattaaccc cgagtgtgac cgatatcgtt actgtcgcaa aagctgcaga agatgcggga
    14761 gcaagtggct tgaccatgat caatactctg gttggaatgc gctttgacct caaaaccaga
    14821 aaaccaatct tggccaatgg aacaggtgga atgtcaggtc cagcagtctt tccagtagcc
    14881 ctcaaactca tccgccaagt agcccaaaca acagacctgc ctatcattgg aatgggggga
    14941 gtggattcgg ctgaagctgc cctagaaatg tatctggctg gggcatctgc tatcggagtt
    15001 ggaacagcta actttaccaa tccttatgcc tgccctgaca tcatcgaaaa tttaccaaaa
    15061 gtcatggata aatacggtat tagcagtctg gaagaactcc gtcaggaagt aaaagagtct
    15121 ctgaggtaaa ctgcaatcaa tctgttcttg attttttatt agtttgtaat atgaatttag
    15181 gagaattttg gtacaataaa ataaataaga acagaggaag aaggttaatg aagaaagtaa
    15241 gatttatttt tttagctctg ctatttttct tagctagtcc agagggtgca atggctagtg
    15301 atggtacttg gcaaggaaaa cagtatctga aagaagatgg cagtcaagca gcgaatgagt
    15361 ggatttttga tactcattat caatcttggt tctatataaa agcagatgct aactatgctg
    15421 aaaatgaatg gctaaagcaa ggtgacgact atttttacct caaatctggt ggctatatgg
    15481 ccaaatcaga atgggtagaa gacaagggag ccttttatta tcttgaccaa gatggaaaga
    15541 tgaaaagaaa tgcttgggta ggaacttcct atgttggtgc aacaggtgcc aaagtaatag
    15601 aagactggat ctatgattct caatacgatg cttggtttta tatcaaagca gatggacagc
    15661 acgcagagaa agaatggctc caaattaaag ggaaggacta ttatttcaaa tccggtggtt
    15721 atctactgac aagtcagtgg attaatcaag cttatgtgaa tgctagtggt gccaaagtac
    15781 agcaaggttg gctttttgac aaacaatacc aatcttggtt ttacatcaaa gaaaatggaa
    15841 actatgctga taaagaatgg attttcgaga atggtcacta ttattatcta aaatccggtg
    15901 gctacatggc agccaatgaa tggatttggg ataaggaatc ttggttttat ctcaaatttg
    15961 atgggaaaat agctgaaaaa gaatgggtct acgattctca tagtcaagct tggtactact
    16021 tcaaatccgg tggctacatg gcagccaatg aatggatttg ggataaggaa tcttggtttt
    16081 acctcaagtt tgatggcaaa atggctgaaa aagaatgggt ctacgattct catagtcaag
    16141 cctggtacta cttcaaatcc ggtggttaca tgacagccaa tgaatggatt tgggataagg
    16201 aatcttggtt ttatctcaaa tctgatggga aaatagctga aaaagaatgg gtctacgatt
    16261 ctcatagtca agcttggtac tacttcaaat ccggtggtta catgacagcc aatgaatgga
    16321 tttgggataa ggaatcttgg ttttacctca agtctgatgg caaaatggct gaaaaagaat
    16381 gggtctacga ttctcatagt caagcctggt actacttcaa atctggtggc tacatggcga
    16441 aaaatgagac agtagatggt tatcagcttg gaagcgatgg taaatggctt ggaggaaaag
    16501 ctacaaataa aaatgctgct tactatcaag tagtgcctgt cacagccaat gtttatgatt
    16561 cagatggtga aaagctttcc tatatatcgc aaggtagtgt cgtatggcta gataaggata
    16621 gaaaaagtga tgacaagcgc ttggctatta ctatttctgg tttgtcaggc tatatgaaaa
    16681 cagaagattt acaagcgcta gatgctagta aggactttat cccttattat gagagtgatg
    16741 gccaccgttt ttatcactat gtggctcaga atgctagtat cccagtagct tctcatcttt
    16801 ctgatatgga agtaggcaag aaatattatt cggcagatgg cctgtatttt gatggtttta
    16861 agcttgagaa tcccttcctt ttcaaagatt taacagaggc tacaaactac agtgctgaag
    16921 aattggataa ggtatttagt ttgctaaaca ttaataatag ccttttggag aacaagggcg
    16981 ctacttttaa ggaagccgaa gaacattacc atatcaatgc cctttatctc cttgcccata
    17041 gtgccctaga aagtaactgg ggaagaagta aaattgccaa agataagaat aatttctttg
    17101 gcattacagc ctatgatacg accccttacc tttctgccaa gacatttgat gatgtggata
    17161 agggaatttt aggtgcaacc aagtggatta aggaaaatta tatcgatagg ggaagaactt
    17221 tccttggaaa caaggcttct ggtatgaatg tggaatatgc ttcagaccct tattggggcg
    17281 aaaaaattgc tagtgtgatg atgaaaatca atgagaagct aggtggcaaa gattagtact
    17341 ataagtgaat atgatttgag tgaatagtaa gttaaaaatc ctgatttcaa gtaaaatcag
    17401 gattttttca tggatgcaat ttttttggag tctggtgtga cgcggagggt cttttgtcct
    17461 gtgtaagtga caaagccggg ttttccacca gttggtttat tgagtttttt gacttcaatc
    17521 atatctacct gcaccagatt cgacaggcgc ccttgagaga agtaggcagc taactctgct
    17581 gcgtctgtct tgactgcatc agatgggtca agatttcctg agatgacaac atggcttcca
    17641 ggaatgtcct tagcatggaa ccaaagttcc tccttgcggg ccattttaaa ggtcaattcc
    17701 tcattttgaa gattgtttcg tccgacatag atgatggttt tgccatcgct tgctagatat
    17761 tgttctagtt ttttgcgttt ctggattttc tcccgttgtc ttctgcggat aaaacctgtt
    17821 tgaatcaatt cttcacggat ttcagcgatt tcttccagtc cagcttggtt gaggacggtt
    17881 tctacacttt ccagatagag aatagtggct ttggtttctt caatcaaatc agtcaagtat
    17941 ttgacagctt ctttgagttt ctgataccgt ttaaaatagc gttgggcatt ctggttggga
    18001 gtcagagcct tatcaagcgc aatcatgata ggttggttgg tatagtagtt gtctaggata
    18061 acctggtctt ggtcgttagg cacttggtgg aggaaggttg tcagcaattc tcctttttga
    18121 cgaaattctt cagcgttgtc tgtcgccagt aactcttttt cctgtttttt gagtttgtgt
    18181 cggtttttct gaagttcatt ttcaacacga cgaatcagtt cactggcctg ctgtttgacg
    18241 cggtcgcgct cagccttatc cttatagtag gtgtccaaca aatcagaaag atttgcaaaa
    18301 ggctctccca cctgatttgc aaaaggaact ggactgaagg aagtctcagt caagcatggc
    18361 ttggtttctt gattgaaaaa atttcggaaa gcggaaagtt tttcactaac cagtatcctt
    18421 tccaattcat ttgccgtatc gcgtcccaga ccttgaaaga ggctttgaag attttttgct
    18481 gttagttctt gggtttgtag gatttcaaag agcttttcat ccttgatagt aaaaggattg
    18541 agagattttg tacttggcgg agcgatatag gtcgatcctg gaagtaaggt gcggtagcta
    18601 ttttgtgaaa aaccgacgtg tttgataact tcgaggattt tatgactgct tttatcgacc
    18661 agtagaatat tactgtgttt tcccataatt tcaataatca aggtagcctg gatatggtct
    18721 ccaatctcgt ttttattgga aactgtaatt tccacaatac ggtcattttc cacttgctca
    18781 atcgactcaa tcagggcccc ctgcaaatac tttctcaaaa ccatgataaa ggtagaaggt
    18841 tgagctggat tttcaaaagt cgtttgggtc agctgaatgc gtccaaaaac tggatgggca
    18901 gaaaggagca ggcgatggct ttggcgattg ctgcggattt gcaagaccaa ctcttgttca
    18961 aaaggctgat tgattttctg gatgcgacca ttcactaatt cgcttcgcaa ttcctcaact
    19021 atgtggtgta aaaaaaatcc gtcaaatgac atcgttctct ccttgtgatt gtattccata
    19081 gtattatatc aaaaaggtag aataaaatca tggaaatgtg gtataataaa gccaagtaaa
    19141 gagaaacgag aagcacatgt atattgaaat ggtagatgaa actggtcaag tttcaaaaga
    19201 aatgttgcaa caaacccaag aaattttgga atttgcagcc caaaaattag gaaaagaaga
    19261 caaggagatg gcagtcactt ttgtgaccaa tgagcgtagt catgaactta atctggagta
    19321 ccgtgacacc gaccgtccga cagatgtcat cagccttgag tataaaccag aattggaaat
    19381 tgcctttgac gaagaggatt tgcttgaaaa tccagaattg gcagagatga tgtctgagtt
    19441 tgatgcctat attggggaat tgttcatctc tatcgataag gctcatgagc aggccgaaga
    19501 atatggtcac agctttgagc gtgagatggg cttcttggca gtacacggct ttttacatat
    19561 taacggctat gatcactata ctccggaaga agaagcggag atgttcggtt tacaagaaga
    19621 aattttgaca gcctatggac tcacaagaca ataaacgaaa atggaaaaat cgtgacttga
    19681 tatccagttt agaatttgcc atcacaggga tttttactgc tatcaaggaa gaacgaaata
    19741 tgcgaaaaca tgcagtgacg gctctagtgg tcatccttgc aggtcttgtt tttcaggtgt
    19801 cacgaatcga atggctcttt ctcctattga gtattttctt ggtagtagcc tttgagatta
    19861 tcaactctgc tattgaaaat gtggtggatt tggccagtca ctatcacttt tccatgctgg
    19921 ctaaaaatgc caaggatatg gcggccggcg cggtattagt ggtttctctt ttcgcagcct
    19981 taacaggcgc attgattttt ctcccacgaa tctgggattt attattttaa acagtaagag
    20041 gaaattatga cttttaaatc aggctttgta gccattttag gacgtcccaa tgttgggaag
    20101 tcaacctttt taaatcacgt tatggggcaa aagattgcca tcatgagtga caaggcgcag
    20161 acaacgcgca ataaaatcat gggaatttac acgactgata aggagcaaat tgtctttatc
    20221 gacacaccag ggattcacaa acctaaaaca gctctcggag atttcatggt tgagtctgcc
    20281 tacagtaccc ttcgcgaagt ggacaccgtt cttttcatgg tgcctgctga tgaagcgcgt
    20341 ggtaaggggg acgatatgat tatcgagcgt ctcaaggctg ccaaggttcc tgtgattttg
    20401 gtggtgaata aaatcgataa ggtccatcca gaccagctct tgtctcagat tgatgacttc
    20461 cgtaatcaaa tggactttaa ggaaattgtt ccaatctcag cccttcaggg aaataacgtg
    20521 tctcgtctag tggatatttt gagtgaaaat ctggatgaag gtttccaata tttcccgtct
    20581 gatcaaatca cagaccatcc agaacgtttc ttggtttcag aaatggttcg cgagaaagtc
    20641 ttgcatctaa ctcgtgaaga gattccgcat tctgtagcag tagttgttga ctctatgaaa
    20701 cgagacgaag agacagacaa ggttcacatc cgtgcaacca tcatggtcga gcgcgatagc
    20761 caaaaaggga ttatcatcgg taaaggtggc gctatgctta agaaaatcgg tagcatggcc
    20821 cgtcgtgata tcgaactcat gctaggagac aaggtcttcc tagaaacctg ggtcaaggtc
    20881 aagaaaaact ggcgcgataa aaagctagat ttggctgact ttggctataa tgaaagagaa
    20941 tactaagtag aggtaggctc atgcctgctt cttgttttta cagaaggagg acttatgcct
    21001 gaattacctg aggttgaaac cgtttgtcgt ggcttagaaa aattgattat aggaaagaag
    21061 atttcgagta tagaaattcg ctaccccaag atgattaaga cggatttgga agagtttcaa
    21121 agggaattgc ctagtcagat tatcgagtca atgggacgtc gtggaaaata tttgcttttc
    21181 tgcctgacag acaaggtctt gatttcccat ttgcggatgg agggcaagta tttttattat
    21241 ccagaccaag tgcctgaacg caagcatgcc catgttttct tccggtttga agatgggggc
    21301 acgcttgttt atgaggatgt acgcaagttt ggaaccatgg aactcttggt gcctgacctt
    21361 ttagacgcct actttatttc taaaaaatta ggtcctgaac caagcgaaca agactttgat
    21421 ttacaggtct ttcaagctgc ccttgccaag tccaaaaagc ctatcaaatc ccatctccta
    21481 gaccagacct tggtagctgg acttggcaat atctatgtgg atgaggttct ctggcgagct
    21541 caggttcatc cagctagacc ttcccagact ttgacagcag aagaagcgac tgccattcat
    21601 gaccagacca ttgctgtttt gggccaggct gttgaaaaag gtggctccac cattcggact
    21661 tataccaatg cctttgggga agatggaagc atgcaggact ttcatcaggt ctatgataag
    21721 actggtcaag aatgtgtacg ctgtggtacc atcattgaga aaattcaact aggcggacgt
    21781 ggaacccact tttgtccaaa ctgtcaaagg agggactgat gggaaaaatc atcggaatca
    21841 ctgggggaat tgcctcaggt aagtcaactg tgacaaattt tctaagacag caaggctttc
    21901 aagcagtgga tgccgacgca gtcgtccacc aactacagaa acctggtggt cgtctgtttg
    21961 aggctctagt acagcacttt gggcaagaaa tcattcttga aaacggagaa ctcaatcgcc
    22021 ctctcctagc tagtctcatc ttttcaaatc ctgaagagca aaaatggtct aagcaaattc
    22081 aaggggagat tatccgtgag gaactggcta ctttgagaga acagttggct cagacagaag
    22141 agattttctt catggatatt cccctacttt ttgagcagga ctacagcgat tggtttgctg
    22201 agacttggtt ggtctatgtg gaccgagatg cccaagtaga acgcttaatg aaaagggacc
    22261 agttgtccaa agatgaagct gagtctcgtc tggcagccca gtggccttta gaaaaaaaga
    22321 aagatttggc cagccaggtt cttgataata atggcaatca gaaccagctt cttaatcaag
    22381 tgcatatcct tcttgaggga ggtaggcaag atgacagaga ttaactggaa ggataatctg
    22441 cgtattgcct ggtttggtaa ttttctgaca ggagccagta tttctttggt tgtacctttt
    22501 atgcccatct tcgtggaaaa tctaggtgta gggagtcagc aagtcgcttt ttatgcaggc
    22561 ttagcaattt ctgtctctgc tatttccgcg gcgctctttt ctcctatttg gggtattctt
    22621 gctgacaaat acggccgaaa acccatgatg attcgggcag gtcttgctat gactatcact
    22681 atgggaggct tggcctttgt cccaaatatc tattggttaa tctttcttcg tttactaaac
    22741 ggtgtatttg caggttttgt tcctaatgca acggcactga tagccagtca ggttccaaag
    22801 gagaaatcag gctctgcctt aggtactttg tctacaggcg tagttgcagg tactctaact
    22861 ggtcccttta ttggtggctt tatcgcagaa ttatttggca ttcgtacaat tttcttactg
    22921 gttggtagtt ttctattttt agctgctatt ttgactattt gctttatcaa ggaagatttt
    22981 caaccagtag ccaaggaaaa ggccattcca acaaaggaat tatttacctc ggttaaatat
    23041 ccctatcttt tgctcaatct ctttttaacc agttttgtca tccaattttc agctcaatcg
    23101 atcggcccta ttttggctct ttatgtacgc gacttagggc agacagagaa tcttcttttt
    23161 gtctctggtt tgattgtgtc cagtatgggc ttttccagta tgatgagtgc aggagttatg
    23221 ggaaagctag gtgacaaggt gggcaatcat cgtctcttgg ttgtcgccca attttattca
    23281 gtcatcatct atctcctctg tgccaatgcc tctagccccc ttcaactagg actctatcga
    23341 ttcctctttg gcttgggaac cggtgccttg attcccgggg ttaatgccct actcagcaaa
    23401 atgactccca aagccggcat ttcgagggtc tttgccttca atcaggtatt cttttatctg
    23461 ggaggtgttg ttggtcccat ggcaggttct gcagtagcag gtcaatttgg ctaccaagct
    23521 gtcttttatg cgacaagcct ttgtgttgcc tttagttgtc tctttaacct gattcaattt
    23581 cgaacattat taaaagtaaa ggaaatctag tgcgagtaaa aattaatctc aaatgctcct
    23641 cttgtgacag tatcaattac ctaaccagta aaaattcaaa aacccatcca gacaagattg
    23701 aggttttaaa gtattgtccc aaggaaagaa aagtaaccct acatcttgaa tctaagtaga
    23761 ttttatggta aaataatagg gattttaagg agtttgatat gtataaccta ttattaacca
    23821 ttttattagt attatctgtt gtgattgtga ttgcaatttt catgcaacca accaaaaacc
    23881 aatccagcaa tgtatttgat gccagttcag gtgatttgtt tgaacgcagt aaagctcgcg
    23941 gttttgaagc tgtaatgcag cgtttgacag ggattttagt ctttttctgg ctagccattg
    24001 ccttagcatt gacggtatta tcaagtagat aagaaaataa tgggcaggac taggtctttg
    24061 cctcttttta tttttaaagg atgtttgaga aggttttaca gtaaaagaaa attaaaaaat
    24121 ctagaaagaa aatatgaaag atagaataaa agaatattta caagacaagg gaaaggtgac
    24181 tgttaatgat ttggctcagg ctttgggaaa agacagttcc aaggattttc gtgagttgat
    24241 taaaaccttg tccttaatgg aaagaaagca ccagattcgc tttgaagaag atggcagtct
    24301 gaccttggaa gccaagaaaa aacatgagat taccctcaag gggatttttc atgcccataa
    24361 aaatggtttt ggttttgtca gcctagaagg ggaagaggac gacctttttg tagggaaaaa
    24421 tgatgtcaac tatgctattg atggtgatac cgtcgaggta gtgattaaga aagtcgctga
    24481 ccgcaataag ggaacagcag cagaagccaa aattattgat atcctagaac acagtttgac
    24541 aacagttgtc gggcaaatcg ttctggatca ggaaaagcct aagtatgctg gctatattcg
    24601 ttcaaaaaat cagaaaatca gtcaaccgat ttatgttaag aaaccagccc taaagttaga
    24661 aggaacagaa gttctcaagg tctttatcga taaataccca agcaagaaac atgatttctt
    24721 tgtcgcgagt gttctcgatg tagtgggaca ctcaacggat gtcggaattg atgttcttga
    24781 ggtcttggaa tcaatggaca ttgtatccga gtttccagaa gctgttgtta aggaagcaga
    24841 aagtgtgcct gatgctccgt ctcaaaagga tatggaaggt cgtctggatc taagagatga
    24901 aattaccttt accattgacg gtgcggatgc caaggacttg gacgatgcag tgcatatcaa
    24961 ggctctgaaa aatggcaatc tggagcttgg ggttcacatc gcagatgttt cttattatgt
    25021 gaccgagggg tctgcccttg acaaggaagc ccttaaccgt gcgacttctg tttacgtgac
    25081 agaccgagtg gtgccaatgc ttccagaacg actatcaaat ggcatctgct ctctcaatcc
    25141 ccaagttgac cgcctgaccc agtctgctat tatggagatt gataaacatg gtcgtgtggt
    25201 caactatacc attacacaaa cagttatcaa gaccagtttt cgtatgacct atagcgatgt
    25261 caatgatatc ctagctggcg atgaagaaaa gagaaaagaa tatcataaaa ttgtaccaag
    25321 tatcgaactc atggccaagc ttcatgaaac tttagaaaac atgcgtgtga aacgtggagc
    25381 tctcaatttt gataccaatg aagcgaagat tttagtggat aaacaaggta agcctgttga
    25441 tatcgttctt cggcagcgtg gcattgccga gcggatgatt gagtctttta tgttgatggc
    25501 taatgaaaca gttgccgaac atttcagcaa gttggatttg ccttttatct atcgaattca
    25561 cgaggagcct aaggctgaaa aggttcagaa gtttattgat tatgcttcga gttttggctt
    25621 gcgcatttat gggactgcca gtgagattag tcaggaggca cttcaagaca tcatgcgtgc
    25681 tgttgaggga gaaccttatg cagatgtatt gtccatgatg cttcttcgct ctatgcagca
    25741 ggctcgttat tcggagcaca atcacggcca ctatggacta gctgctgact attatactca
    25801 ctttaccagt ccaattcgtc gttatccaga ccttcttgtt caccgtatga ttcgggatta
    25861 cggccgttct aaggaaatag cagagcattt tgaacaagtg attccagaga ttgcgaccca
    25921 gtcttccaac cgtgaacgtc gtgccataga agctgagcgt gaagtcgaag ccatgaaaaa
    25981 ggctgagtat atggaagaat acgtgggtga agagtatgat gcagttgtat caagtattgt
    26041 caaattcggt ctctttgtcg aattgccaaa cacagttgaa ggcttgattc acatcactaa
    26101 tctacctgaa ttttatcatt tcaatgagcg tgatttgact cttcgtggag aaaaatcagg
    26161 tatcactttc cgagtgggtc agcagatccg tatccgtgtt gaaagagcgg ataaaatgac
    26221 tggagagatt gatttttcat tcgtacctag tgagtttgat gtgattgaaa aaggcttgaa
    26281 acagtctagt catagtggca gagggcgtgg ttcaaatcgt cgttcggata agaaggaaga
    26341 caagagaaaa tcaggacgct caaatgataa gcgtaagcat tcacaaaaag acaagaagaa
    26401 aaaaggaaag aaaccttttt acaaggaagt agctaagaaa ggagccaagc atggcaaagg
    26461 gcgagggaaa ggtcgtcgca caaaataaaa aggcacgcca cgactataca atcgtagata
    26521 cgctagaggc agggatggtc ctgactggaa ctgaaatcaa gagtgtacga gctgctcgaa
    26581 ttaatctcaa ggatggcttt gctcaagtga aaaatggaga agtttggctg agcaatgttc
    26641 atatcgcgcc ttacgaagag ggcaatatct ggaaccagga accagaacgt cgtcgtaaac
    26701 tcctgctcca taaaaagcaa attcaaaaat tggaacaaga gaccaaaggg acaggaatga
    26761 ccttagttcc ccttaaggtc tatataaaag atggctacgc taagcttctt ttaggacttg
    26821 ccaaagggaa gcatgactat gacaaacggg agtctatcaa acgtcgtgag caaaatcgag
    26881 atatcgcgcg tgtgatgaaa gctgttaatc agcgataaaa agaggaattg aaaatggaaa
    26941 aattagttgc ctataaacgc atgcctttgt ggaataaaca aacaatgcct gaagctgttc
    27001 agcaaaagca caatacaaaa gttgggactt gggggaaaat tactgtcttg aagggagctc
    27061 tcaagtttat tgaattgaca gaagaagggg aagttctagc tgaacacctc tttgaagcag
    27121 gggcagacaa tccaatggcc caacctcaag cctggcaccg agtggaagct gccacagatg
    27181 atgtggaatg gtacttggaa ttttattgta aacctgagga ttattttgct aaaaaataca
    27241 ataccaatcc tgttcattca gaggtcctag aggccatgca gacagtgaaa caagggaaag
    27301 ctttggattt gggttgtggt caggggcgta attctctttt tctagcccag caagattttg
    27361 atgtgacggc tgtagatcaa aatggactag ctcttgaaat cttgcaaagc attgtggagc
    27421 aggaagattt ggacatgcct gttggccttt acgatatcaa ttcagctagc attgaacaag
    27481 aatatgattt tatcgtttca acagttgttc tcatgtttct acaagcggac cgcattccag
    27541 ctattattca aaatatgcag gagaaaacca gtgttggtgg ttacaacctt atcgtttgtg
    27601 ccatggacac ggaggattat ccttgctcgg ttaacttccc attcaccttt aaagaaggag
    27661 aactggcaga ctattacaag gattgggaat tggttaagta caatgaaaat ccaggccatt
    27721 tgcaccgtcg cgatgagaat ggcaatcgta ttcaactacg ctttgcgacc ttactagcta
    27781 agaaaatcaa gtaaacacac atgaagatta ggaattttcc tgatcttttt tcttttttac
    27841 gaatgatata gaaaaggagg gaattcatgt ttgttgcgag agatgctagg ggagaattgg
    27901 taaatgtgtt agaggataaa cttgagaagc aagcatacac ctgcccagct tgtggaggcc
    27961 agatccattt gcgtcaagga ccaagtgtac ggacgcattt tgcccataaa ttcttaaaag
    28021 actgtgattt tttctttgaa aatgaaagtc cagaacacct ggccaataag gaatccctct
    28081 atcactggtt gaaaaaagag acaaaggttc aattagagta cccgctttca gaacttaaac
    28141 agattgcgga tgtatttgta aatggcaatc tagctctaga agttcagtgt agtcccttgc
    28201 ctcagaaagt ccttaaagag cgaagtgagg gctatcgtag tcagggttac caagtactgt
    28261 ggttgctggg tcaaaaactg tggctcaagg agcgtttgac tcgtctacag caaggttttc
    28321 tttatttcag tcaaaacatg ggcttttatg tttgggaatt agacaaggaa aaacaagttt
    28381 taagactcaa atacctgatt taccaggatc tccgcggtaa actccattat caaatcaagg
    28441 aattttccta tggtcaaggt agtttattgg aaatattgcg tcttccctat aagaaacaaa
    28501 aaatatctca ttttacagtt tctgaggaca aggacatctg tcgctatatc cggcaacaac
    28561 tttattatca aaatctcttt tggatgaaag aacaagcaga agcctatcaa aagggagaaa
    28621 atatcctgac ttatggactg aaagaatggt atccacaaat tcgaccaata gtgggcaaat
    28681 ttttccagat tgaacaagac ttgactagct attatcagca cttttatacc tattaccaaa
    28741 aaaatcctca aaatgattgg caaaagcttt atccaccagc cttttatcag caatatttct
    28801 tgaaaaatat ggtagaatag aaaggatgga ggaatctaat ggtattacaa agaaatgaaa
    28861 taaatgaaaa agatacatgg gatctatcaa cgatctaccc aactgaccag gcttgggaag
    28921 aagccttaaa agatttaaca gaacaattgg agacagtagt ccagtatgaa ggccatctct
    28981 tggatagtgc ggataaccta ctagaaatca ctgaattttc tcttgaaatg gaacgccaga
    29041 tggagaagct ttacgtttat gctcatatga agaatgacca ggatacacgt gaagctaagt
    29101 atcaagagta ctatgccaag gccatgacac tctacagcca gttagaccaa gccttttcat
    29161 tctatgagcc tgaatttatg gagattagcg aaaagcagta tgctgacttt ttagaagctc
    29221 aaccaaagct gcaggtttat caacactatt ttgacaagct cttgcaaggc aaggatcacg
    29281 ttctttcaca acgtgaaaaa gaattattgg ctggagctgg agaaatcttt ggttcagcaa
    29341 gtgaaacctt cgctatcttg gacaatgcgg atattgtgtt cccttatgta ctagacgatg
    29401 atggtaaaga agttcaacta tctcatggga cttacacacg tttgatggag tctaaaaaac
    29461 gtgaggttcg ccgtggtgcc tatcaagctc tttatgcgac ttacgaacaa ttccaacaca
    29521 cctatgccaa aaccttgcaa accaatgtta aggtgcaaaa ttaccgtgct aaagttcgta
    29581 actacaagag tgctcgtcat gcagccctcg cagcgaattt tgttccagaa agtgtttatg
    29641 acaatttggt agcagcagtt cgcaagcatt tgccactctt acatcgctat cttgagcttc
    29701 gttcaaaaat cttggggatt tcagatctca agatgtacga tgtctacaca ccgctttcat
    29761 ctgttgaata cagttttacc taccaagaag ccttgaaaaa agcagaagat gctttggcag
    29821 tcttgggtga ggattacttg agccgtgtca aacgtgcctt cagcgagcgt tggattgatg
    29881 tttacgaaaa tcaaggcaag cgttcaggtg cctactctgg tggttcttac gataccaatg
    29941 cctttatgct tctcaactgg caggacaatc tggacaatct ctttactctt gttcatgaaa
    30001 caggtcacag tatgcattca agctatactc gtgaaactca gccttatgtt tacggagatt
    30061 actctatctt tttggctgag attgcctcaa ctaccaatga aaatatcttg acggagaaat
    30121 tattggaaga agtggaagac gacgcaacac gctttgctat tctcaataac ttcctagatg
    30181 gtttccgtgg aacagttttc cgccaaactc aatttgctga gtttgaacac gccattcacc
    30241 aagcagatca aaatggggag gtcttgacaa gcgatttcct aaataaactc tacgcagact
    30301 tgaaccaaga gtattatggt ttgagtaagg aagacaatcc tgaaatccaa tacgagtggg
    30361 ctcgcattcc acacttctac tataactact atgtatatca atattcaact ggctttgcgg
    30421 ccgcctcagc cttggctgaa aaaattgtcc atggtagtca agaagaccgt gaccgctata
    30481 tcgactacct caaggcaggt aagtcggact atccacttaa tgtcatgaga aaagctggtg
    30541 ttgatatgga gaaggaagac tacctcaacg atgcctttgc agtctttgaa cgccgtttaa
    30601 atgagtttga agcccttgtt gaaaaattag gattggcata aaatggttga atcgtatagt
    30661 aagaatgcta accataacat gcgtcgtcct gtcgtcaaag aagaaattgt agacttgatg
    30721 cgtcagcgtc aaaagcaagt cacaggtttc ttgaaagaat tggaagactt tgcccgcaag
    30781 gaaaatattc ctattattcc ccatgaaacg gttgcttatt tccgttttct tatggaaacc
    30841 atgcagccta aaaatattct ggaaattggg acggctatcg gtttttcagc tctcttgatg
    30901 gctgaacatg cgccaaatgc taagattaca actattgatc gtaatccaga aatgattggt
    30961 tttgccaagg aaaattttgc ccagtttgac agtcgcaagc aaatcactct cctagaggga
    31021 gatgcggtgg atgtcttatc tacactgaca gagtcttatg atttcgtctt tatggattct
    31081 gccaagtcta aatacatcgt ctttctgcca gaaattctca aacatttgga agttggtggt
    31141 gtggttgtct tggatgatat tttccaaggc ggtgatgttg ccaaggacat tatggaagtc
    31201 cgtcgaggtc agcgaaccat ctatcgaggc cttcaaagac tatttgacgc aaccttagac
    31261 aattcagaac tcaccgcaac attagtgcct ttaggagatg gtattctcat gcttcgtaaa
    31321 aatgtagcag atgttcaatt gcctgacagc gaatgatttt cagaaaaatt taagaaaaaa
    31381 tagtaaaata gatagagtaa cacttatctc aaaggagtag acatgaagaa aaaattattg
    31441 gcaggtgcca tcacactatt atcagtagca actttagcag cttgttcgaa agggtcagaa
    31501 ggagcagacc ttatcagcat gaaaggggat gtcatcacag aacatcaatt ttatgagcaa
    31561 gtgaaaaaca acccttcagc ccaacaagtc ttgttaaata tgaccatcca aaaagttttt
    31621 gaaaaacaat atggctcaga gcttgatgat aaagaggttg atgatactat tgccgaagaa
    31681 aaaaaacaat atggcgaaaa ctaccaacgt gtcttgtcac aagcaggtat gactcttgaa
    31741 acacgtaaag ctcaaattcg tacaagtaaa ttagttgagt tggcagttaa gaaggtagca
    31801 gaagctgaat tgacagatga agcctataag aaagcctttg atgagtacac tccagatgta
    31861 acggctcaaa tcatccgtct taataatgaa gataaggcca aagaagttct cgaaaaagcc
    31921 aaggcagaag gtgctgattt tgctcaatta gccaaagata attcaactga tgaaaaaaca
    31981 aaagaaaatg gtggagaaat tacctttgat tctgcttcaa cagaagtacc tgagcaagtc
    32041 aaaaaagccg ctttcgcttt agatgtggat ggtgtttctg atgtgattac agcaactggt
    32101 acacaagctt acagtagcca atattacatt gtaaaactca ctaagaaaac agaaaaatca
    32161 tctaatattg atgactacaa agaaaaatta aaaactgtta tcttgactca aaaacaaaat
    32221 gattcaacat ttgttcaaag cattatcgga aaagaattgc aagcagccaa tatcaaggtt
    32281 aaggaccaag ccttccaaaa tatctttacc caatatatcg gtggtggaga ttcaagctca
    32341 agcagtagta catcaaacga atagtccaaa tcaatgagtc agggaaaaaa actcgacttc
    32401 aggaaaaaat gaagcaaaca ttcccacaat aaaacgcata gtacaaggtt tgtactgccc
    32461 ccaaaagtta gacaattaat ttatctgaag gatttagttc tgtattgcac agggctaagt
    32521 ccttttagtt ttaccttaat tctcttattg ttctaataat caatatagtc tataatggct
    32581 tgttccaatt gattaagtga tttaaatgtt ttctcatagc cataaaacat ttcggatttt
    32641 aaaatgccaa agaaagattc catcctaccg ttgtcttggc tgtttccttt gcgtgacata
    32701 gatgcttgaa ttcccttact ctctaggaag cgatgataag aatcgtgttg gtattgccag
    32761 ccttggtcac tatggagaat cgtattctcg tagtgcttct ctttgaatgc ctgttccaac
    32821 attaacgatc aatcaattta atcatgtacc taatattaga attgtttatc ccaaatttat
    32881 ttgaaagctt ctctaagcta tatccttgtt ttctaagttc atagatctga actttatcat
    32941 cataagttaa tttcataata aaaacacccc aaaagttaga ttttttctgt ctaacttttg
    33001 gggtgtagtt catgtacacc tgatatgatg cgttttataa ttttaaagac tttttgacca
    33061 gcctcatttt tttaacttga tactcagtga aaagcaaaga ttaaactaga aagctagccg
    33121 caggctgctc aaagaacagc tttgaggttg cagataaaac ttgtgaggta accaacatat
    33181 ataatgtgaa gctgacgtgg tttgaataga ttttagaagg gtatgagtct ggaagtttta
    33241 atggataatg caagattcca tagaatgggt aagctagagt tcttatgtga agagtttggg
    33301 cataaacttt taccttttcc tccctactca tcttagtata gaaaagtgaa tctaaaatag
    33361 tacataactg cttctaaaac attcttataa attgatttaa attctcaaat catattattc
    33421 agttcttatt tcattttgct ctacaatcct gttgagaaga cacgtgttca tatcaaaaag
    33481 gtattggcaa gttgcaatac ctttttacaa ggttcttttg tcttattttt gtttcaactg
    33541 actatatctc ctatggttct agttcagaag gctaggctat aattatgatt gataagaagt
    33601 atcattccaa gtattgagag tgaatgtttc aaaatcatgg gtttctataa tggtcaggct
    33661 ggcatttgct agaccgccat ctttacgaag aagtggttct ttatagccta ggagagtacg
    33721 aagactggca gtaagattgg cgccgtgtcc gacaattaga atacgctcag ctggactatc
    33781 ttttaatgat ttgataaatt ggatggtccg ctgagttgta ctatagaggg attcggctcc
    33841 gaacattcga gtgtcaaatt gagcaagatt tgaacgaaaa gcctggattt gttgcgggta
    33901 aatagcttcc agggttgcaa ttttcaaacc ttctaacttc ccaagttgcc attcacggag
    33961 attaggaacg atttctaaag aacagggggt atagagttga ctttggataa tctcagcaga
    34021 tttgaccgct cgaggtaaat cacttgaata aatctgatca aaaggaattt ccttgagata
    34081 ctgaccaagt cgttttaggg tttcaatgga ttcaggaaga agaggagaat caccactagc
    34141 accttgaaaa cgaccttctt ggttccagag ggtacgaccg tggcggacaa agtagagttt
    34201 cattacttga tgtcctccaa aatatctaca aagtctgcct ttacaaagct agccaagtct
    34261 tgtggcgcga cgataatgct gtgtccgact tcgcctgcag agacaatcat ttgatccaaa
    34321 tctagagcaa ttttatcgat aaaaatggga taattgtgtt tctgacgaat tccgacagga
    34381 ttattggctc catgaatgta accagttgtt ttttctaagt ccttttgtgg aatcatgctc
    34441 acttttttat tgccagaaat tttagctagt ttcttttcag acaagtgctg agtgataggg
    34501 acaattccga taatcggtcc ggtcttgtct cccaaaagcg ccaaggtttt gaaaatctga
    34561 tctcgttcat aaccttgagg aagctctcct tctagggcat tgatttgaat cccctgatga
    34621 gggatagctg ctttagatag gatttgttcc accaatgttt ttttgatttt aacttttttt
    34681 gccattattt atatttatcc tccaattgac tcatccaaat accaagccag attcccagcg
    34741 caaagaagaa ggcgatgatg acataaccga caagtgaaag tcctgtgtat tggatacttt
    34801 cagcgtttcc tgcatttgga attaagatca aaagggtact tgataggacg ataccgatga
    34861 tgaaatgata gacgcgtgag tggtagttgt ttaaggcata atccatcaat tttgaaaaaa
    34921 cgatgagagt tgcacctgca ccaattccaa tcggaaagaa ggttcccaag aaatcaaaag
    34981 ttttaaaacc agtcaacata ggagcatata gtcccaaaat caaaagtaaa tttgatgggc
    35041 tgaggccagg aaccaagacg ccaagggcca atagtgcgcc tgctaggacg aagttaagaa
    35101 agctggcgct taaggttcca acgacaaaat ttaaggcata gagtcctaat ccagaaatga
    35161 taaaggttgt ccataaccaa gctaaatcaa tcttgtctcg gtcagattct cgagttgatt
    35221 ctttgaggag gctaggaact gtaccgataa tagctcccgc aaagctccat aatacaaaaa
    35281 cctgataatt ttcaagcagg tattcaatcg ggtaggaaaa taagccgatt cccagaagca
    35341 taccgatggc aactggaata aagtacaaaa cattttcttt aaagtcttta aagggatggg
    35401 ccagaaagcc aatcattcgt tcatagattc ctaagattgc tgctagaacc cctccggaaa
    35461 ttcccggtag gataaatcca agagcaatta caatcccttt aataacgcgt gctaaccatg
    35521 agagcatata tttcctccaa ctatttctat ttcaaaaaat ccttactata ttgtatcaca
    35581 atcagacaca aaaagaaaaa gcaaatgata aacaaatgct tttaaggttt taaaaaaagt
    35641 tttcgaaagg tttcttcttt attttttaag ggagagataa cgttgatatc taaatcgtgg
    35701 tcaaagccgg caatttttcc tttagatgtg tattggtgaa tatcataatc taaatcagtt
    35761 ttaggactgc tctccaaaaa tcctgagtct gagccgtagg acggaatcca aacagaggta
    35821 aacttgcctg tatcaatact gtgttcttcc atgaagtaga caccaacgta gatgccgatg
    35881 tttttagcac ctagtgatgc tagttttgct cgaaagtttt cgacaccttc gttcatatta
    35941 gacatggttt tgtcttccac gtcaagccaa tagtaactag ggctgtaagg agaggcagca
    36001 ttgtagaaaa cttcggcagc cttttccatt tcttggacac tttttccagc tacataagcg
    36061 tagacagcaa ctgggacatt ccgcttttga agttcagtga tatgactctt ataggccttg
    36121 tctattccat tgataaatga agcatcattt tcttttgttg tttgagcacc actgtgaaca
    36181 cgaacaatag cacctgaaat attttgtgag agggcatcgt agttgatttc ctcaggacgc
    36241 tgccagccag agaggtcaat aatcggtttg tctaagtgtt tcaaagcctg tgctatattg
    36301 gattttgttt taaacgattg gctgtcatta agtgggcgat tgatgattaa aatgaacatc
    36361 ataatcccaa aaaaactaaa taaaataagt ggatgaattt gttttctcat atcttataag
    36421 tctaccctaa aaatcaaaaa aaatcaaaaa aatgggttaa ggaagagact ttagagcatt
    36481 ttttcattca agagtgcgga atgatttgaa atatggtata ataaaaggga atttctacag
    36541 aaaagagaag attatgtcaa attttgccat tattttagca gcgggtaaag ggactcgcat
    36601 gaaatctgat ttgccaaaag ttttgcacaa ggttgcgggt atttctatgt tggaacatgt
    36661 tttccgtagt gtgggagcta tccaacctga aaagacagta acagttgtag gacacaaggc
    36721 agaattggtt gaggaggtct tgactggaca gacagaattt gtgactcaat ctgaacagtt
    36781 gggaactggt catgcagtta tgatgacaga acctatctta gaaggtttgt caggacacac
    36841 cttggtcatt gcaggagata ctcctttaat cactggtgaa agcttgaaaa acttgattga
    36901 tttccatatc aatcataaaa atgtggccac tatcttgact gctgaaacgg ataatccttt
    36961 tggctatgga cgaattgttc gtaatgacaa tgctgaggtt cttcgtattg ttgagcagaa
    37021 ggatgctaca gattttgaaa agcaaatcaa ggaaatcaac actggaacat acgtctttga
    37081 caacgagcgt ttgtttgagg ctttgaaaaa tatcaatacc aataacgctc aaggcgaata
    37141 ctatattaca gacgtcattg gtattttccg tgaaactggt gaaaaagttg gcgcttatac
    37201 tttgaaagat tttgatgaaa gtcttggggt aaatgaccgt gtggcgcttg cgacagctga
    37261 gtcagttatg cgtcgtcgca tcaatcataa acacatggtc aacggtgtta gctttgtcaa
    37321 tccagaagca acttatatcg atattgatgt tgagattgct ccggaagttc aaatcgaagc
    37381 caatgttacc ttgaaagggc aaacgaaaat tggtgctgag actgttttga caaatggtac
    37441 ttatgtagtg gacagcacta tcggagcagg agcggtcatt accaattcta tgattgagga
    37501 aagtagtgtt gcagacggtg tgacagtcgg tccttatgct cacattcgtc caaattcaag
    37561 tctgggtgcc caagttcata ttggtaactt tgttgaggtg aaaggatctt caatcggtga
    37621 gaataccaag gctggtcatt tgacttatat cggaaactgt gaagtgggaa gcaacgttaa
    37681 tttcggtgct ggaactatta cagtcaacta tgacggcaaa aacaaataca agacagtcat
    37741 tggagacaat gtctttgttg gttcaaattc aaccattatt gcaccagtag aacttggtga
    37801 caattccctc gttggtgctg gttcaactat tactaaagac gtgccagcag atgctattgc
    37861 tattggtcgc ggtcgtcaga tcaataaaga cgaatatgca acacgtcttc ctcatcatcc
    37921 taagaaccag taggagccta tcatggagtt tgaagaaaaa acgcttagcc gaaaagaaat
    37981 ctatcaagga ccaatattta aactggtcca agatcaggtt gaattaccag aaggcaaggg
    38041 aactgcccaa cgggatttga ttttccacaa tggggctgtc tgtgttttag cagtaacgga
    38101 tgaacaaaaa cttatcttgg tcaagcagta ccgcaaagct atcgaggcag tctcttacga
    38161 aattccagct ggaaaattgg aagtaggaga aaacacagcc cctgtggcag ctgcccttcg
    38221 tgaattagag gaagaaacag cctatacagg gaaattagaa ctcttgtacg atttttattc
    38281 agctattggc ttttgtaatg agaagttaaa actatattta gcaagcgatt taacaaaagt
    38341 ggaaaatccg cgtccgcagg atgaggatga aaccttggaa gtccttgaag tgagcttaga
    38401 agaagcgaaa gaattaatcc aatcaggtca tatttgtgat gccaagacaa ttatggctgt
    38461 tcagtattgg gagttgcaga aaaaatagag gaggtcagta tgggtaaatc tttattaacg
    38521 gatgaaatga ttgaaagagc taatagaggc gaaaaaattt caggtcctcc tttgctagat
    38581 gataatgagg aaactaagat tttaccaacc tcttcttccc gttttggtta tgccaatcct
    38641 aaggatcatg gttttagcca ggaaaccttg aagattcagg tcgaaccatc tattcataaa
    38701 agccgtcgta ttgaaaatac caagagaaat gtcttcaatt ctaagttgaa taaaatctta
    38761 tttgcggtca tttttctctt gattttgctt gttttagcaa tgaaactttt gtaatagaaa
    38821 aggaattgaa atgaaaatag gaattattgc tgctatgcca gaagaactgg cttatctggt
    38881 ccagcattta gataatgccc aggagcaagt tgttttgggg aatacctatc atacaggaac
    38941 cattgcttct catgaagtcg ttcttgtaga aagtggaatt ggtaaggtca tgtctgctat
    39001 gagtgtggcg attttggctg atcatttcca ggtggatgcc cttattaata cgggttcagc
    39061 tggggcagta gcagaaggta tcgctgttgg ggatgtcgtg attgctgaca aattagccta
    39121 tcatgacgtg gatgtcacag cttttggcta tgcttatgga caaatggcgc aacaaccgct
    39181 ttatttcgaa tcagacaaaa cctttgttgc tcaaatccaa gagagtttat ctcaattgga
    39241 ccaaaactgg cattttggtt tgattgctac aggagatagt tttgttgcag gaaatgacaa
    39301 gatagaagcg attaagtccc atttcccaga agttttagcc gtggagatgg agggggcagc
    39361 tattgctcaa gcagcgcatg ccctcaatct cccagtctta gtcatcagag ctatgagtga
    39421 caatgccaac catgaagcaa acatcttttt tgatgagttt attatcgaag ctggacgtcg
    39481 ctctgcccaa gtcttgttga cctttttgaa ggctttagat taagcggaaa tttgacagtt
    39541 tttctagctt atgataagat ttaagtaaag aaaagctaga aaacgtttca gaggatatta
    39601 tgagtattga aatgaccgtc agtgagattg cagaggtctt aggattatct cgccaagcaa
    39661 tcaataaccg tgtcaaagaa ttaccagaag aagacacaga taaaaatgac aaaggggtaa
    39721 cagttgttac cagaagtggc ttgattaagc tagaagaaat ctataaaaaa acgatttttg
    39781 aagatgagcc tgtcagtgaa gatgtcaaac aacgtgaact gatggagatt ctagtggatg
    39841 agaagaatgc agaaattctt cgtctttatg aacaattaaa agccaaggat cgtcagttat
    39901 cagaaaaaga cgagcagatg cgtatcaaag accgtcagat tgctgagaaa gacaaacaat
    39961 tagatcagca acaacaattg acccttcaag ccatgaagga tcaagaaaat cttaagctag
    40021 agctggacca agcaaaagaa gaagtccaat ccactaaaaa aggctttttt gctcgtttat
    40081 ttggaggata atcaaggagc tgtttaggtt aaatgctaac ctgatggctt cttttgtttg
    40141 tgaatagtat agttgattag aacagagaca gtagaggaga ggtacagaat ggaacgatta
    40201 gaagattaca ttgcttttga cttagaattt aatcagcacg aaggacaaaa acacttgatt
    40261 caagtatcgg cagtgcgttt tagagatggt cgggaaatcg atgcctatga ttcctatgtt
    40321 cataccagcg tccctctaaa aagctttatc aatggtttga ccgggattac agctgagacc
    40381 ttaaaagatg ctcctccagt tgagaaagtc ttagaagaat tccaagagtt tgtgggttct
    40441 ttgctgatga taggctacaa tgctgctaaa agtgatttac ctattttagc agagtatggt
    40501 ttagactata gccaacagta caaggtggat ttgtatgatg aagcttttga acgtcggagt
    40561 tcagatttac atggtattgc caatctcaaa ttgcaaactg ttgcctcatt tcttggattt
    40621 caaggtcagt ctcataatag tttagaggat gctcggatga cggcgcgtgt ttacgaatcc
    40681 ttcttagagt cggatcaagc tagggaattg ttagagacag aaagtagctt atcaaacaat
    40741 ccttttggtg gcttggactt gtctcaatta tttgactagg agtgcctatg aaacctgaaa
    40801 aacctaaaaa attgggtctt aaacagattt acctcaatct tgataaaatc ctctttctat
    40861 ttttcttgat ttttatgata gtggagtatt tgtgggtacc attcaattca tggttggcta
    40921 gcttcttatt agatcagaca ggttatcttt ttatttccta taacaatgtc ttagccatcc
    40981 ttactcattc tccattgatt agtctagctt ttttagcctt gattgtaatt aaccttctgg
    41041 ttgcttattt tcaaatagga ctcctcttta ttggtgctcg tcatctcctc tataatgaaa
    41101 agcgaaggct aattgagtat atccgcaagg ttttccatga aagttttgga tttatgaaaa
    41161 agctaacttg cgctaaagcc ttgtttatct ttttctatat agctatgctt tttcctttta
    41221 tacggaaaat gctgaagatt tattatctta ataaaatcgt cattccagag tttatccaag
    41281 cttatttaga agataaatat tggatgtggt ggctgagcat cctacttcta tctcttatct
    41341 ttctctatgt ctctgtcaga ttgatgtttg cccttccgaa gattgtatat gatcagctga
    41401 ctgttcgaga agcagtgatg tttagcttgg agaaaaccaa gaagagagtt actttttatg
    41461 cttggaattt attttacatc ttgctcaaag cacatttatt attttatctt cctttgattc
    41521 ctttattatt ggctcaaact ttggtagatg atatcactca gagagagtct ctgattcttg
    41581 gtattttgaa ttttgtcgtg attaaaaatc tctattatat ggctctgact tattttttgg
    41641 ttaaatttgt ttcatttttg acaggaaagg agctggatat gcttcctagg agagaaaaag
    41701 atcacatcgt gcgatggggt gtcatgactt gtgccagtct tttctttgcc ttagaaggtt
    41761 atatttatct ggaggctccc atggttcatc tacctcaact tatttctcac cgaggggttt
    41821 ccaatgcaaa tgggattcaa aatacagtag agtccttgga aactacagca caactcaaac
    41881 cagacttggt ggagacggac gtgcaggaaa caaaagatgg gcagtttgtc atgatgcatg
    41941 atgctaactt gaaaaatcta gcaggtatca ataaaagtcc tcaagactta aacttggagg
    42001 agcttaaagg gattgatatt tttgaaaatg gctaccagac taaaatttca agctttgaag
    42061 attatctcag tcgagccaac gaacttggtc aaaaattact aattgaaatt aaaaccagta
    42121 aaaaagatag tccagacatg atgaaccgct ttttagcccg ttatgctgca aagctcaaga
    42181 tttatggaca tcaaatccag tctttagact accatgttgt cgaaaaagta agacagtatg
    42241 atgccgaact gccagtttat ttcatcatgc cctacaattc tgtctttcct aaaacaagag
    42301 cgacaggata tactatggag tactcaacct tggatgaata ttttgtaagc aaactatgga
    42361 caacggatca gaaactttat gtctggactg tcaatgattc agaagctatc agcaaatctc
    42421 ttcacttagg agtagatgga gtgattacag atgatttgga aaaagttcag cgggaaatag
    42481 aagtagccca agaagatcca gaatatacgg atttgctctt gaaaaaagca ttggaattct
    42541 ttgaatttta gtaataaaaa agaggaacgg ttgttcctcc catgataggt aagtattctt
    42601 gtgaatgctt gcttttttgt ggttgcaatc cgtttacgag aattgtttgt attgttcttg
    42661 tttcaattta cttta
//
LOCUS       DBERMM010000015        39805 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.015, whole genome shotgun sequence.
ACCESSION   DBERMM010000015 DBERMM010000000
VERSION     DBERMM010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 39805)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39805)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39805
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.015"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..251)
                     /locus_tag="ACL8AS_001027"
     CDS             complement(<1..251)
                     /locus_tag="ACL8AS_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
                     /protein_id="HGS1228904.1"
                     /translation="MEQLHFITKLLDIKDPNIQILDIINKDTHKEIIAKLDYDAPSCP
                     ECGNQLKKYDFQKPSKIPYLETTGMPSRILLRKRRFKCY"
     gene            complement(385..1733)
                     /locus_tag="ACL8AS_001028"
     CDS             complement(join(385..1292,1292..1733))
                     /locus_tag="ACL8AS_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HGS1228905.1"
                     /translation="MKLSYDDKVQIYELRKQGYSLEKLSNKFGINNSNLRYMIKWIDR
                     YGIEFGKKGKNRYYSPDLKQEMINKVLHEGWTKDRVSLEYGLPSRTILLNWLAQYRKN
                     GYTIVEKPRGRVPKMGRKPRTRPEERTELERLQAENEYLRAENAIPKKVKRTPIEGGK
                     RERRKTEIVQELMTEFSLVLLLKSIKLARWTYYYHLKQLDKTDKDQELKAEIQSIFIE
                     HKGNYAYRRVHLELRNRGYLVNHKRVQGLIKVLNLQAKMRQKRKYSSHKGDVGKKAEN
                     LIQGQFEGSKTMEKCYTDVTEFAIPASTQKLYLSPVLDGFNSEIIAYNLSTSPNLEQV
                     QTMLEQSFTEKHYENTILHSDQGWQYQHDSYHQFLEGKGIQASISRKGNSPDNGMMES
                     FFGILKSEMFYGYEKTFKSLNRLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFG"
     gene            complement(1829..2809)
                     /gene="dusB"
                     /locus_tag="ACL8AS_001029"
     CDS             complement(1829..2809)
                     /gene="dusB"
                     /locus_tag="ACL8AS_001029"
                     /EC_number="1.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0017150 - tRNA dihydrouridine synthase
                     activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HGS1228906.1"
                     /translation="MTNLNTPFMIGNVEIPNRTVLAPMAGVTNSAFRTIAKELGAGLV
                     VMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIV
                     DINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVE
                     NALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAK
                     QRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLIN
                     LKGENVAVREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKA"
     gene            complement(2796..3668)
                     /gene="hslO"
                     /locus_tag="ACL8AS_001030"
     CDS             complement(2796..3668)
                     /gene="hslO"
                     /locus_tag="ACL8AS_001030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HGS1228907.1"
                     /translation="MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGR
                     TLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATG
                     EVLVGPFVGNGQFLVITDYGAGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNV
                     LLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIY
                     GDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYN
                     FDEKDLEELIRDKS"
     gene            3833..5260
                     /locus_tag="ACL8AS_001031"
     CDS             3833..5260
                     /locus_tag="ACL8AS_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1228908.1"
                     /translation="MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLT
                     KYVTLLNDKALDSGLELAIHSEDENLRLSIGAATKGRDIRSLFLESAVKYQILVYLLY
                     HQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIRYFYFCLF
                     RKVWSSQEWEGHMQKPERKQEIANLEEICGASLSVGQKLDLVLWAHISQQRLRVNACQ
                     FQVIEEKMRGYFDNIFYLRLLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLH
                     TMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYELSQLCAQVYLYKGYILQD
                     RYKYQLENRHPYLLMEHDFKETAEEIFHALPTFQQGTDLDKKILWEWLQLIEYMAENG
                     GQHMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKE
                     QTPVYYLKNDLDMEDLAGIRQLLFT"
     gene            5419..6927
                     /gene="glpK"
                     /locus_tag="ACL8AS_001032"
     CDS             5419..6927
                     /gene="glpK"
                     /locus_tag="ACL8AS_001032"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004370 - glycerol kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006072 - glycerol-3-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HGS1228909.1"
                     /translation="MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAG
                     WVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAI
                     VWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEDAQERAEKGE
                     LLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEV
                     RSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNT
                     GEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYA
                     RDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDI
                     IDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGL
                     SVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD"
     gene            6969..8795
                     /gene="glpO"
                     /locus_tag="ACL8AS_001033"
     CDS             6969..8795
                     /gene="glpO"
                     /locus_tag="ACL8AS_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004368 - glycerol-3-phosphate
                     dehydrogenase (quinone) activity [Evidence IEA];
                     GO_process: GO:0006072 - glycerol-3-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glycerol-3-phosphate oxidase"
                     /protein_id="HGS1228910.1"
                     /translation="MEFSKKTRELSIKKMQERTLDLLIIGGGITGAGVALQAAASGLE
                     TGLIEMQDFAEGTSSRSTKLVHGGLRYLKQFDVEVVSDTVSERAVVQQIAPHIPKPDP
                     MLLPVYDEDGATFSLFRLKVAMDLYDLLAGVSNTSAANKVLSKDQVLERQPNLKKEGL
                     VGGGVYLDFRNNDARLVIENIKRANQDGALIANHVKAEGFLFDESGKITGVVARDLLT
                     DQVFEIKARLVINTTGPWSDKVRNLSNKGTQFSQMRPTKGVHLVVDSSKIKVSQPVYF
                     DTGLGDGRMVFVLPRENKTYFGTTDTDYTGDLEHPKVTQEDVDYLLGIVNNRFPESNI
                     TIDDIESSWAGLRPLIAGNSASDYNGGNNGTISDESFDNLIATVESYLSKEKTREDVE
                     SAVSKLESSTSEKHLDPSAVSRGSSLDRDDNGLLTLAGGKITDYRKMAEGAMERVVDI
                     LKAEFDRSFKLINSKTYPVSGGELNPANVDSEIEAFAQLGVSRGLDSKEAHYLANFYG
                     SNAPKVFALAHSLEQAPGLSLADTLSLHYAMRNELTLSPVDFLLRRTNHMLFMRDSLD
                     SIVEPVLDEMGRFYDWTEEEKATYRADVKATLANNDLAELKN"
     gene            8863..9567
                     /locus_tag="ACL8AS_001034"
     CDS             8863..9567
                     /locus_tag="ACL8AS_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MIP/aquaporin family protein"
                     /protein_id="HGS1228911.1"
                     /translation="MMSELFGEFLGTLILILLGNGVVAGVVLPKTKSNSAGWIVITMG
                     WGIAVAVAVFVSGKLSPAHLNPAVTVGVALKGDLPWASVLPYILAQFAGAMLGQILVW
                     LQFKPHYEVEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQAG
                     IGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPIPNKGDGDWSYAWIPVV
                     GPVIGAALAVLVFSLF"
     gene            9912..10067
                     /locus_tag="ACL8AS_001035"
     CDS             9912..10067
                     /locus_tag="ACL8AS_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="eukaryotic translation initiation factor 3
                     subunit E"
                     /protein_id="HGS1228912.1"
                     /translation="MVDMLVEFHKSQGTLETPEAQAEIAQKREEIEQRRAELEDKKQE
                     LLNRLNK"
     gene            complement(10154..10762)
                     /locus_tag="ACL8AS_001036"
                     /pseudo
     CDS             complement(10154..10762)
                     /locus_tag="ACL8AS_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844696.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            10894..11091
                     /locus_tag="ACL8AS_001037"
     CDS             10894..11091
                     /locus_tag="ACL8AS_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000930586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228913.1"
                     /translation="MLNAKIFYIFLCLIVIETTGLLLLKRGLEMGYLDTEAIILAVFS
                     FAFYNLCSFAWVCSTIKNNKK"
     gene            11901..13178
                     /gene="ltrA"
                     /locus_tag="ACL8AS_001038"
     CDS             11901..13178
                     /gene="ltrA"
                     /locus_tag="ACL8AS_001038"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HGS1228914.1"
                     /translation="MSKLLDKILSRENMLEAYNQVKSNKGSAGIDGMTIEEMDNYLRQ
                     NWRLTKELIKQRKYKPQPVLRVEITKPNGGIRQLGIPTVMDRMIQQAIVQVISPICEP
                     HFSDTSYGFRPNRSCEKAIMKFLEYLNDGYEWIVDIDLEKFFDTVPQDRLMSLVHNII
                     EDGDTESLIRKYLHSGVIINGQRHKTLVGTPQGGNLSPLLSNVMLNELDKELEKRGLR
                     FVRYADDCVITVGSEAAAKRVMYSASRFIEKRLGLKVNMTKAKITRPRELKYLGFGFW
                     KSSDGWKSRPHQDSVRRFKLKLKKLTQRKWSIDLTRRIEQLNLSIRGWINYFSLGNMK
                     RIVASIDERLRTRLRVIIWKQWKKKSRRLWGLLKLGVPKWIADKVSGWGDHYQLVAQK
                     SVLKRAISKPVLEKRGLVSCLDYYLERHALKVS"
     gene            13635..14813
                     /locus_tag="ACL8AS_001039"
     CDS             13635..14813
                     /locus_tag="ACL8AS_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ryptide export MFS transporter"
                     /protein_id="HGS1228915.1"
                     /translation="MSNSFVKLLVSQLFANLADIFFRVTIIANIYIISKSVIATSLVP
                     ILIGISSFVASLLVPLVTKRLALNRVLSLSQFGKTILLAILVGMFTVMQSVAPLVTYL
                     FVVAISILDGFAAPVSYAIVPRYATDLGKANSALSMTGEAVQLIGWGLGGLLFATIGL
                     LPTTFIILVLYIISSFLMLFLPNAEVEVLESETNLEILLKGWKLVARNPRLRLFVSAN
                     LLEIFSNTIWVSSIILVFVTELLNKTESYWGYSNTAYSIGIIISGLIAFRLSEKFLAA
                     KWESILFPLVAMAIVTLTILYFPNAQMFLLFSALVGMLSQLKEVPESVFLQETVEENH
                     LVNVYSVLEVISTLAFSVFVLLMSYITESFGISISFWLSAICLMIEAILIYIRRDYFK
                     "
     gene            15127..15258
                     /locus_tag="ACL8AS_001040"
     CDS             15127..15258
                     /locus_tag="ACL8AS_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="teichoic acid D-Ala incorporation-associated
                     protein DltX"
                     /protein_id="HGS1228916.1"
                     /translation="MKQRKELYLFLGRTALYFLIFLGLLYFFSYLGQGQGSFIYNEF"
     gene            15279..16829
                     /gene="dltA"
                     /locus_tag="ACL8AS_001041"
     CDS             15279..16829
                     /gene="dltA"
                     /locus_tag="ACL8AS_001041"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0047473 - D-alanine [D-alanyl carrier
                     protein] ligase activity [Evidence IEA];
                     GO_process: GO:0019350 - teichoic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltA"
                     /protein_id="HGS1228917.1"
                     /translation="MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDS
                     LAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEV
                     AEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
                     GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGT
                     LFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMSGITHFYFDG
                     EELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADS
                     PTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGT
                     MTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLL
                     AYVILKDGVREQFERDIDITKAIKEDLTDIMMSYMMPSKFLYRDSLPLTPNGKIDIKG
                     LINEVNKR"
     gene            16826..18070
                     /gene="dltB"
                     /locus_tag="ACL8AS_001042"
     CDS             16826..18070
                     /gene="dltB"
                     /locus_tag="ACL8AS_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0070395 - lipoteichoic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HGS1228918.1"
                     /translation="MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYE
                     VLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLFYKHYRKSKDGKWVFYLVSFLSL
                     LPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIIIELRDGVIKDFTLWEFLRFLLFM
                     PTFSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMWGFLYKFILAHVLGETLLP
                     PLKNLALQSGGFFNLYALAVMYTFGLELFFDFAGYSMFALAISNLMGIRSPINFNKPF
                     LSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRNVTSSMAYIVNMLIMGF
                     WHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVT
                     FHVVMLSFLIFSGFLNNLWFKK"
     gene            18084..18323
                     /gene="dltC"
                     /locus_tag="ACL8AS_001043"
     CDS             18084..18323
                     /gene="dltC"
                     /locus_tag="ACL8AS_001043"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005591431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0036370 - D-alanyl carrier activity
                     [Evidence IEA];
                     GO_process: GO:0019350 - teichoic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HGS1228919.1"
                     /translation="MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVE
                     IENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA"
     gene            18316..19584
                     /gene="dltD"
                     /locus_tag="ACL8AS_001044"
     CDS             18316..19584
                     /gene="dltD"
                     /locus_tag="ACL8AS_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0070394 - lipoteichoic acid metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HGS1228920.1"
                     /translation="MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVAT
                     TIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFDGAHPAVLAEKYNRSYRPYLLGQG
                     GAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTSFLKHQ
                     SGDQASQYAATRLLQQFPNVAMKDLVQKLASKEELSTADNEMIELLARFNERQASFFG
                     QFSVRGYVNYDKHVAKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQI
                     KKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSKSKVNPIFIIPPVNKKWMDYAGLRE
                     DMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVDPFLS
                     NPTPAPTYHLNERFFSKDWATYDGDVKEFQ"
     gene            19739..20179
                     /gene="adcR"
                     /locus_tag="ACL8AS_001045"
     CDS             19739..20179
                     /gene="adcR"
                     /locus_tag="ACL8AS_001045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent transcriptional regulator AdcR"
                     /protein_id="HGS1228921.1"
                     /translation="MRQLAKDINAFLNEVILQAENQHEILIGHCTSEVALTNTQEHIL
                     MLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLAR
                     PIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEIK"
     gene            20179..20883
                     /locus_tag="ACL8AS_001046"
     CDS             20179..20883
                     /locus_tag="ACL8AS_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HGS1228922.1"
                     /translation="MRYITVEDLSFYYDKEPVLEHINYCVDSGEFVTLTGENGAAKTT
                     LIKASLGILQPRIGKVAISKTNTQGKKLRIAYLPQQIASFNAGFPSTVYEFVKSGRYP
                     RKGWFRRLNAHDEEHIKASLDSVGMWEHRDKRLGSLSGGQKQRAVIARMFASDPDVFI
                     LDEPTTGMDAGSKNEFYELMHHSAHHHGKAVLMITHDPEEVKDYADRNIHLVRNQDSP
                     WRCFNVHENGQEVGHA"
     gene            20876..21682
                     /locus_tag="ACL8AS_001047"
     CDS             20876..21682
                     /locus_tag="ACL8AS_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HGS1228923.1"
                     /translation="MLSLLSYDFIQRAFLAVIAMSLFSPVLGTFLILRRQSLMSDTLS
                     HVSLSGVAFGLVLGISPTVSTIAIVLIAAVFLEYLRTVYKSFMEIGTAILMSTGLAVS
                     LIVMSKGKSSSSMSLDQYLFGSIVTISEEQVISLFVIAAVVLILTFLFLRPMYILTFD
                     EDTAFVDGLPVRTMSILFNMVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKNFKS
                     VMLLASAIGFLGMVAGLYISYYAETPASASITIIFVTVFILISLVRRFIK"
     gene            21692..23197
                     /gene="adcA"
                     /locus_tag="ACL8AS_001048"
     CDS             21692..23197
                     /gene="adcA"
                     /locus_tag="ACL8AS_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding
                     lipoprotein AdcA"
                     /protein_id="HGS1228924.1"
                     /translation="MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQ
                     VAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKK
                     KVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLS
                     ADYPDKKETFEKNAAAYIEKLQALDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQ
                     VAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLN
                     PLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAA
                     VKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTK
                     INITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFS
                     DHNVAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYPDNLSGQEIAQEMLAH"
     gene            complement(24326..25099)
                     /locus_tag="ACL8AS_001049"
     CDS             complement(24326..25099)
                     /locus_tag="ACL8AS_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HGS1228925.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLE
                     NQGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCIYLDSST
                     TVYELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKE
                     NSLLDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNIIDKAHETILLIDSSKFYKTG
                     FFKINPLSKYTTFISDTLPDQKLLDAVELFDGEWVSDIQ"
     gene            25275..26678
                     /locus_tag="ACL8AS_001050"
     CDS             25275..26678
                     /locus_tag="ACL8AS_001050"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rhamnulokinase family protein"
                     /protein_id="HGS1228926.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGH
                     LSWDVDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLSQPVHYRDERT
                     KGLLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFN
                     YLLTGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDSSLLPEIVSEGNVLGRIKKE
                     YGLGDIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPLLTTESFSYGF
                     TNEVGKDGVITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTE
                     STEFATESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKV
                     YKRIYVIGGGARASYFNQMIADRTGKEVLTGLTEGTAVGNIVVQLLSQGKINEDTELK
                     DIMTNIAETQYYYPQLS"
     gene            26707..27591
                     /locus_tag="ACL8AS_001051"
                     /pseudo
     CDS             26707..27591
                     /locus_tag="ACL8AS_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036440.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            28149..29828
                     /locus_tag="ACL8AS_001052"
     CDS             28149..29828
                     /locus_tag="ACL8AS_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HGS1228927.1"
                     /translation="MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQE
                     DPERFNPSQLDAREWVRVLKETGFKKLILVVKHHDGFVLYPTAHTDYSVKVSPWRRGK
                     GDLLLEVSQAATEFDMDMGVYLSSWDAHSPLYHVDREADYNAYYLAQLKEILSNPNYG
                     NAGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGDCLIFSTEGTSIRWIGNERGY
                     AGDPLWQKVNPDKLGTEAELDYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLE
                     ELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKDIERLYEFATYRNELYKEDLALGAEVS
                     GPALSADFACRHLTDGLETSSWASDADLPIQLELDLGFPKTFDVIELREDLKLGQRIA
                     AFHVQVEVDGVWQEFGRGFTVGHKRLLRGPLVEAQKVRVMITEAQSIPVLTKISLYKT
                     PGLSKKEVVQELAFAEKSLAVAKGENAYFTVKRRECSGPLEAKISIQPGTGVHGVAYQ
                     DEIYVLQFQAGESKKDLHLPTLYFAGDKTLDFYLNLTVDGQLVDQLQVQVS"
     gene            complement(29868..31952)
                     /locus_tag="ACL8AS_001053"
     CDS             complement(29868..31952)
                     /locus_tag="ACL8AS_001053"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000803403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030246 - carbohydrate binding [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GH92 family glycosyl hydrolase"
                     /protein_id="HGS1228928.1"
                     /translation="MKPLLETIDTRFGTASKHAFSRGNTLPYTGVPLGMNYFVPQTSD
                     QGGSWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTSQLGGDSLFHRQSSYDIDK
                     ACFQPHYLKLFSLRYQIETQLTPTCYGASIRLNQKQGKALSLYLHAADELTVEQVDKR
                     TLALRQEGKTETNKNPLMLFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS
                     PSQALINLPQEDFDSCKTSAQADWENLLHRFDIIETGEADRTFFDHCLYRLFLFPQTF
                     YEVDESGQAIHMDLATGTVKPGVLFSNNGFWDTFRTTFPLFALIIPEHYQRFLEGFLN
                     SYRDTGFLPKWLAPDERGMMPGTLLDGIIADSACKDMAPDLEGELFQAMLETASKADP
                     LGINGRHGLAQYQELGYLSTDHHESVSHTLDYAYSDFCIASCAKKLENIEIAETYKAA
                     SQNYRQLFDAETGYMRARDNQGNFHPDFSPYSWGRDYAECSAIQATLGVLHDIPGLIQ
                     LMGGKETFSNYLLKACQDAPLFETTGYGYEIHEMSEMATAPFGQIAISNQPSFHIPYL
                     FRYSDYPDYTALLIKTLRQKAFHPSWEAYPGDEDNGSLSAWYIWSALGFYPTCPGKPS
                     YDLGIPLFDHLRVYLAKEDKWLDIHTKQNHNHFNFVKECRLNKTLVSTIQHQDLLKAE
                     QLTFTLSWLPSH"
     gene            32123..33403
                     /locus_tag="ACL8AS_001054"
     CDS             32123..33403
                     /locus_tag="ACL8AS_001054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HGS1228929.1"
                     /translation="MIYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL
                     EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDALLRQTIAGLVKRQMTLVLKDPYA
                     NSFNIEENWKGHHETDHTDLNGWIWERKYEVDSLCYPLQLAYLLWKETGETGQFDETF
                     VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD
                     DCCQYSYLIPSNMFAVVVLGYVQEIFAALNLADSQSVIADAKRLQDEIQEGIKNYAYT
                     TNSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSVDDEVYQATRRTILSSEN
                     PYFYQGEYASGLGSSHTFYRYIWPIALSIQGLTTRDKAEKKFLLDQLVACDGGTGVMH
                     ESFHVDDPTLYSREWFSWANMMFCELVLDYLDIR"
     gene            33494..36139
                     /locus_tag="ACL8AS_001055"
     CDS             33494..36139
                     /locus_tag="ACL8AS_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HGS1228930.1"
                     /translation="MENIVVHIISHSHWDREWYLPFESHRMQLVELFDNLFDLFENDP
                     EFKSFHLDGQTIVLDDYLQIRPENRDKVQRYIDEGKLKIGPFYILQDDYLISSEANVR
                     NTLIGQQEAAKWGKSTQIGYFPDTFGNMGQAPQILQKSGIHVATFGRGVKPIGFDNQV
                     LEDEQFTSQFSEMYWQGVDGSRVLGILFANWYSNGNEIPVDKDEALTFWKQKLSDVRA
                     YASTNQWLMMNGCDHQPVQKNLSEAIRVANELFPDVIFVHSSFDEYVQAVEGALPEHL
                     STVTGELTSQETDGWYTLANTSSSRIYLKQAFQENSNLLEQVVEPLTIITGGHNHKDQ
                     LTYAWKTLLQNAPHDSICGCSVDEVHREMETRFAKVNQVGNFVKSNLLNEWKGKIATD
                     KAQSDYLFTVINTGLHDKVDTVSTVIDVATCDFKELHPTEGYKKMAALILPSYRVEDL
                     DGRPVEATIEDLGANFEYDLPKDKFRQARIARQVRVTIPVHLAPLSWTTFQLLEGKQE
                     HREGIYQNGVIDTPFVTVSVDDNITVYDKTTHEAYEDFIRFEDRGDIGNEYIYFQPKG
                     TEPIFAELKGHEVLENTDRYAKILLKHELTVPVSADEKLEEEQQGIIEFMKREAGRSE
                     ELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSESIYEVVT
                     RPNKPAASWENPENPQHQQAFVSLYDDEKGVTVSNKGLNEYEILGDNTIAVTILRASG
                     ELGDWGYFPTPEAQCLREFEVEFALECHQAQERFSAFRRAKALQTPFTSLQLARQEGS
                     VVATGSLLSHSVLSIPQICPTAFKVAENEEGYVLRYYNMSQENVRISEHQQTILDLLE
                     RPYPVHSGLLAPQEIRTELIKKEEI"
     gene            36223..37092
                     /locus_tag="ACL8AS_001056"
     CDS             36223..37092
                     /locus_tag="ACL8AS_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HGS1228931.1"
                     /translation="MTIATIDIGGTGIKFASLTPDGKILNKTSIPTPESLEDLLAWLD
                     QRLSEQDYSGIAMSVPGAVNQETGVIDGFSAVPYIHGFSWYEALSSYQIPVHLENDAN
                     CVGLSELLAHPELENAACVVIGTGIGGAMIINGRLHRGRHGLGGEFGYMTTLAPAEKL
                     NNWSQLASTGNMVRYVIEKSGQTDWDGRKIYQEAAAGNAICQEAIERMNRNLAQGLLN
                     IQYLIDPDVISLGGSISQNPDFIQGVKKAVEDFVDTYEEYTVAPVIQACTYHADANLY
                     GALVNWLQEENQW"
     gene            37086..38966
                     /locus_tag="ACL8AS_001057"
     CDS             37086..38966
                     /locus_tag="ACL8AS_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HGS1228932.1"
                     /translation="MVRFTGLSSKQAQAIEVLKNHISLPDVEVAVTQSDQASISIKGE
                     GGHYQLTYRKPHQLYRSLSLLVTALAEADKVEIEEQAAYEDLAYMADCSRNAVLNVAS
                     AKQMIEVLALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF
                     VPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMFATLSKLKTRKVN
                     IGMDEAHLVGLGRYLILNGVVDRSLLMCQHLERVLDIADKYGFHCQMWSDMFFKLMSA
                     DGQYDRDVEIPEETRVYLDRLKDRVTLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAG
                     GAWKWIGFTPHNHFSRLVAIEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQIW
                     AELSYRNDLDSLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDVL
                     CPILDRHMTPEQDKPHFAQAAGTIADIKEKAGNYAYLFETQAQLNAILSSKVDVGRRI
                     RQAYQADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENKVFGLDTVDIRMGGLL
                     QRIKRAESRIEVYLAGQLDRIDELEVEILPFTDFYADKDFAATTANQWHTIATASTIY
                     TT"
     gene            39380..39706
                     /locus_tag="ACL8AS_001058"
     CDS             39380..39706
                     /locus_tag="ACL8AS_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid pRiA4b ORF-3 family protein"
                     /protein_id="HGS1228933.1"
                     /translation="MILWSFDFVNAHAHAFFMDNVEWSHADSYFLSFVSDDVEERYTE
                     NVYLDSLSVKQKFKFIFDFGDEWRFECQVLREIETEDEEAYLVRSVGTSPEQYPDYDG
                     FDYEEW"
BASE COUNT        11620 a         7572 c         8920 g        11693 t
ORIGIN      
        1 tgatagcact tgaaacggcg ttttctaagg agaattctag aaggcatacc agttgtttcg
       61 aggtaaggga tcttagacgg tttttgaaag tcatatttct tcaattgatt tccgcactca
      121 gggcaagatg gggcgtcgta gtccagtttg gcgatgattt ccttgtgtgt atccttattg
      181 atgatgtcta aaatctggat attagggtct ttaatgtcta gtaattttgt gataaaatgt
      241 aattgttcca tatgattctt tctaatgagt tgttttgtcg cttttcatta taggtcatat
      301 gggacttttt ttctacaata aaataggctc cataatatct atagtggatt tacccactac
      361 aaatattata gaaccacaat taatttatcc gaaggattta gttctgtatt gcacagggct
      421 aagtcctttt agttttacct taattcgttt attgttgtag taatcaatat agtctacaat
      481 agcttgttcc aatcgattaa gtgatttaaa tgttttctca tagccataaa acatttccga
      541 tttcagaatc ccaaaaaagg actccatcat accattgtct gggctgttac ccttacgtga
      601 aatggatgct tgaattccct taccctcaag aaactgatga taagaatcgt gttgatattg
      661 ccagccttgg tcactatgga gaatcgtatt ctcgtagtgc ttctctgtga atgactgttc
      721 caacattgtt tgtacttgtt ctaaattggg tgaagttgaa agattatagg cgataatttc
      781 gctgttaaag ccatctaaaa ctggtgataa gtaaagcttt tgagtacttg ctggaatggc
      841 aaattctgtc acatctgtgt agcacttttc cattgtttta gagccttcaa attggccttg
      901 aatgagattc tctgccttct tgccaacgtc tcctttatga gaagaatatt ttcgtttctg
      961 tcgcatttta gcttgtaaat tgagtacttt tatcaagcct tgaactcttt tatgatttac
     1021 cagataacca cgatttctta gttctaaatg aacccggcga taagcataat ttcccttgtg
     1081 ttcgataaaa atggattgaa tttcagcttt aagctcttgg tccttatctg ttttgtctag
     1141 ctgtttcaag tgatagtagt aggtccaacg agctagttta atggatttta gaagaagaac
     1201 taacgaaaac tcagtcatta attcttgaac aatttctgtc tttcttcttt ctctttttcc
     1261 tccttcaatc ggagttctct taactttttt aggatggcat tctccgctct caggtactca
     1321 ttttctgctt gaagacgttc taattctgtc ctctcttcag gtctcgttct tggcttacgt
     1381 cccattttag gtactctccc tcttggtttc tcaacaatag tatacccgtt tttcctgtat
     1441 tgtgctagcc agttaagaag tatcgtacga cttgggagac cgtattcaag agaaactcta
     1501 tctttagtcc agccttcatg taagacttta ttaatcattt cttgttttaa atcaggagaa
     1561 tagtaacgat tttttccttt tttgccgaac tctattccgt aacgatcaat ccatttaatc
     1621 atatacctaa gattagaatt atttatccca aatttatttg aaagcttctc taagctatat
     1681 ccttgctttc ttagttcata gatctgaact ttatcatcat aacttaattt cataataaaa
     1741 acaccccaaa agttagattt tttctgtcta acttttgggg tgcagttcat tttgagcttt
     1801 cccgtttttc tgagttgtag atgtaagact atgccttctc caattgcaag agagcttcaa
     1861 tctctgctag ggtgctagct tgcgaaatgg ctccacggag tttggcagcg ccagatgttc
     1921 cacggaggta gtgaggagcg aggccgcgga attcacgaac tgcgacgttt tctcctttga
     1981 ggttaatcaa tcgtttcaag tgttcgtagg cgatcttcat cttgtcttca aaggtcaaat
     2041 caggtaggat ttctcctgtt tcaaagtaat ggttgatttg gttgaagagg taaggatttc
     2101 ccatggcagc tcggccaatc atgactgcgt cagcaccaac ttcttcgatg cgttgcttgg
     2161 cttcttggac agtacggata tcaccgttgg cgatgaatgg aatcttggtt agagcttggg
     2221 caaccttgta aagggtctca aggtctgcgt ggccagtata catttgttca cgggtacggc
     2281 catgcatggc gagggcagaa acacctgcag cctcagcagc gagggcattt tctactgcca
     2341 gagatgggtc cgcccagccg gtacgcattt tgacagtaag tgggatatca aggacagact
     2401 ggaccttgtt gatgatagag tagatcttgt caggatcctt gagccacata gcaccagctt
     2461 cgttcttcac gattttgttg acagggcagc ccatgttgat atcgacgata tcggtcttgg
     2521 tgttttcttg gatgaattct gctgcgcgtg ctaggctgtc ttcatcgcta ccaaaaagtt
     2581 ggatagagac agggttttcg ccctcatcga tatgaagcat gtgcagggtt ttttcgttgt
     2641 tgtattggat tcccttgtca gagaccattt ccattacaac gagtccagct ccgagctctt
     2701 ttgcgatggt acgaaaggct gagttggtca cgccagccat aggcgctaaa acggtacgat
     2761 tgggaatctc aacattgcca atcataaaag gtgtattaag atttgtcacg aatgagttcc
     2821 tccaggtcct tttcatcaaa gttgtaagta gtttggcaga attgacaagt gatttctgcc
     2881 ccgtggtctt cctctttcat ttcctgtaag tctgagcttg gaaggctggc aagagcgttc
     2941 ataaagcgtt catggctaca gtcacattgg aaacggattt cttcttcaga aagacgcttg
     3001 taggcttcgt ccccgtagat agccttgagg agggcttcga tatggtcgtc gctttcgaga
     3061 agagtagaga tagctggcat ttcttggatg cgtttttcaa agcgagcaat ctcttctttc
     3121 ttggctcctg gcaagacttg aactaggaaa ccacctgcaa ccttgacctt gtcttcctcg
     3181 tccaaaagga cattgaggcc gaccgctgaa ggcgtttgtt ggctttcagt aaggtaaaag
     3241 gcaaggtctt caccgatttc tccagagatg aggggagtta tagagttgta aggatttcca
     3301 gcaccgtagt ctgtgataac gaggaattga ccatttccaa caaaaggtcc gactaggact
     3361 tcaccagtcg cagtcttttt gatgtcaaca ccaggatttt gaacatagcc tttgacgttc
     3421 cccttggtat cagcgacggt gataatagca cctagagagc tagagcccaa caccttaact
     3481 gtaagtttgg tatttccttt ttcattggct gcgagaatct ggctggcgat aagagttcga
     3541 ccaagcgcta cagttgagct agcttgggtt tgatgttttt cttgagcagt gcggacggtt
     3601 tccgtgctat caaggacaaa agcacgaaag gctccgcttt ctgatatagt tttaataatt
     3661 ttatccatag ctactatttt agcataaaaa tgcccaaagg gggagccgtg tgtttactga
     3721 ttttcaggat aatggaccag gaaatcagca tgaaaataaa aagagaaaca gattatttta
     3781 gcatttgtaa gatttatgct atgcttaagg tagaaaatga aaggggtaac aaatgtattt
     3841 aggagatttg atggagaaag ccgagtgtgg tcaattttca atcctttcct ttctattaca
     3901 agagtctcag acgaccgtca aggctgtaat ggaagaaaca ggattttcaa aagcaaccct
     3961 aaccaaatat gtcaccctgc tcaatgacaa ggctttggat agtggcttag agctggctat
     4021 tcactcagaa gatgaaaatc tgcgtctgtc tatcggtgca gctaccaagg ggagagatat
     4081 tcggagcttg tttttggaga gtgctgttaa ataccagatt ttggtttatc ttctctacca
     4141 ccaacagttt ttagcccatc agctggctca agaattggtg attagcgagg ctacgcttgg
     4201 tcgtcacttg gctggtttaa atcagatttt gtcagaattt gatttatcca tccaaaatgg
     4261 acgttggcga ggtccagagc atcagattcg ctatttctat ttctgtcttt tccgaaaggt
     4321 ctggtcgagt caggaatggg aaggtcacat gcagaaacca gagagaaaac aggagattgc
     4381 caatttagag gaaatctgcg gtgcaagttt gtctgtgggg cagaaattgg acttggttct
     4441 ctgggctcac atcagtcaac aacgtcttcg ggtcaatgct tgtcagtttc aagtcataga
     4501 agagaaaatg cgagggtatt ttgacaatat tttctacctt cgtttgctga gaaaggttcc
     4561 gtcctttttt gctgggcaac atattccact aggagttgag gatggtgaga tgatgatatt
     4621 cttctctttt ctcctatctc atcgcattct tcctcttcat actatggagt atattcttgg
     4681 ttttggaggg cagttggcag atttactgac gcaattgatt caagaaatga agaaggagga
     4741 actattgggg gattatacag aggaccatgt cacctatgaa ctcagtcagc tttgtgctca
     4801 agtctatctc tataagggct atattttaca ggatcgctac aagtaccagt tagagaatcg
     4861 tcatccatat ttactgatgg aacatgattt taaagagaca gcagaggaga tttttcatgc
     4921 tctacctact tttcaacagg ggacagattt agataagaag attctctggg aatggctcca
     4981 gttaatcgaa tatatggctg aaaacggtgg ccagcatatg cggattggtc tggatttgac
     5041 atctggtttt cttgtctttt caaggatggc agccattttg aaacggtatt tggaatacaa
     5101 tcgttttatt accattgaag cttatgaccc tagtcggcat tatgatttgc tggttaccaa
     5161 taaccctatt cataagaagg aacagacacc agtctattat ttaaaaaatg acttggatat
     5221 ggaagatttg gcagggattc gtcagttatt attcacttaa aaggcttggt taatctaggt
     5281 cttttttgtg aaattcacac aatctcctca cattttttta aaaattaaaa aaagttgata
     5341 aacaagaaag cgctttattt tgtatactag taagtgtaaa gaggaaacac ctcaagatct
     5401 ttatcaggag gacagtacat gtcacaagaa aaatacatca tggccattga ccagggaact
     5461 acaagttctc gtgccatcat tttcaacaaa aaaggggaaa aggttagctc gagtcaaaaa
     5521 gagtttaccc agattttccc tcaggcaggt tgggttgagc acaatgccaa tgaaatttgg
     5581 aactctgttc agtcagttat tgcgggtgct ttcatcgaaa gtggtgtcaa gccaaatcaa
     5641 atcgaggcaa tcgggattac caaccaacgt gaaacaacgg ttgtctggga taagaaaaca
     5701 ggacttccta tctacaatgc tatcgtttgg cagtcacgcc agacagcacc tttggctgag
     5761 caactaaaaa gccaaggtta tgtggaaaaa ttccatgaaa agactggttt gattattgat
     5821 gcttacttct ctgctaccaa ggttcgttgg attttggatc atgtagaaga tgctcaagag
     5881 cgagcagaaa aaggggaatt gctctttggt actatcgata cttggttggt ttggaaattg
     5941 actgacggtg cggctcacgt gactgactac tcaaatgcag ctcgtaccat gctttataac
     6001 attaaagaac tcaaatggga tgatgagatt ttggaaatcc ttaacattcc gaaggctata
     6061 cttccagaag ttcgttctaa ctccgaaatc tacggcaaga cagctccatt ccatttctac
     6121 ggtggagagg tgccaatctc aggtatggct ggggaccaac aagcagccct ctttggacag
     6181 ttggcttttg agccaggtat ggttaagaat acttatggaa caggctcttt catcatcatg
     6241 aatactgggg aagagatgca gttgtctgaa aacaacctct tgacaaccat tggttacgga
     6301 atcaacggta aggtttatta tgccttggaa ggttctatct tcatcgcagg aagtgctatt
     6361 cagtggcttc gtgacggtct tcgcatggtt gaaaattcac cagaatctga aaaatacgct
     6421 cgtgattctc acaacaacga tgaagtttat gtcgttccag cctttacagg tctaggcgct
     6481 ccatactgga accaaaatgc tcgtggttcc gtctttggtt tgactcgtgg aacaagcaaa
     6541 gaagacttta tcaaggcgac tttgcaatct attgcttatc aagtgcgtga catcatcgac
     6601 actatgcaag tggatactca gactgccatt caagtactga aggtggatgg tggtgcagcc
     6661 atgaacaact tcctcatgca gttccaggcg gatattttag gcattgacat tgcacgtgct
     6721 aaaaacttgg aaacaacagc tctaggagcg gccttcctag caggtttgtc agtagggtac
     6781 tggaaagact tggacgagtt gaaactcttg aacgagacag gagaactctt tgagccatct
     6841 atgaatgaat ctcgcaagga acaactctac aagggctgga agaaggctgt gaaagcaact
     6901 caagtctttg cggaagtaga cgactaatac tggcagaata aagcgattta tttagaaagt
     6961 gtgtaaatat ggaattttca aagaaaacac gtgaattgtc aattaaaaaa atgcaggaac
     7021 gcaccctgga cctcttgatt atcggtggag gaatcacagg agctggtgta gccttgcagg
     7081 cggcagctag cggtcttgag actggtttga ttgaaatgca agactttgca gaaggaacat
     7141 ctagtcgttc aacaaaattg gttcacggag gacttcgtta cctcaaacaa tttgacgtag
     7201 aagtggtctc agatacggtt tctgaacgtg cagtggttca acaaatcgct ccacacattc
     7261 caaaaccaga tccaatgctc ttaccagttt acgatgaaga tggagcaacc tttagcctct
     7321 tccgtcttaa agtagccatg gacttgtacg accttttagc aggtgtgagc aacacgtcag
     7381 ctgcgaacaa ggttttgagc aaggatcaag tcttggaacg ccagccaaac ttgaagaagg
     7441 aaggcttggt aggaggtgga gtgtatcttg acttccgtaa caacgatgcg cgtctcgtga
     7501 ttgaaaacat caaacgtgcc aaccaagacg gtgccctcat tgccaaccac gtgaaggcag
     7561 aaggcttcct ctttgacgaa agtggcaaga ttacaggtgt tgtagctcgt gatctcttga
     7621 cagaccaagt atttgaaatc aaggcccgtc tggttattaa tacaacaggt ccttggagtg
     7681 ataaagtacg taatttgtct aataagggaa cgcaattctc acaaatgcgc ccaactaagg
     7741 gagttcactt ggtagtggat tcaagcaaaa tcaaggtttc acagccagtt tactttgaca
     7801 caggtttggg tgacggtcgt atggtctttg ttctcccacg tgaaaacaag acttactttg
     7861 gtacaactga tacagactac acaggtgatt tggagcatcc aaaagtaact caagaagatg
     7921 tagattatct acttggcatt gtcaacaacc gctttccaga atccaacatc accattgatg
     7981 atatcgaaag cagctgggca ggtcttcgtc cattgattgc agggaacagt gcctctgact
     8041 ataatggtgg aaataacggt accatcagtg atgaaagctt tgacaacttg attgcgactg
     8101 ttgaatctta tctctccaaa gaaaaaacac gtgaagatgt tgagtctgct gtcagcaagc
     8161 ttgaaagtag cacatctgag aaacatttgg atccatctgc agtttctcgt gggtctagct
     8221 tggaccgtga tgacaatggt cttttgactc ttgctggcgg taaaatcaca gactaccgta
     8281 agatggctga aggagctatg gagcgcgtgg ttgacatcct caaagcagaa tttgaccgta
     8341 gctttaaatt gatcaattct aaaacttacc ctgtttcagg tggagaattg aacccagcaa
     8401 atgtggattc agaaatcgaa gcctttgcgc aacttggagt ttcacgtggt ttggatagca
     8461 aggaagctca ttacctagca aatttttacg gttcaaatgc accgaaggtc tttgcacttg
     8521 ctcacagctt ggaacaagcg ccaggtctta gcttggcaga caccttgtcc cttcactatg
     8581 caatgcgcaa tgagttgact cttagcccag ttgacttcct tcttcgtcgt accaatcaca
     8641 tgctctttat gcgtgatagc ttggatagta tcgttgagcc agttttggat gaaatgggac
     8701 gattctatga ctggacagaa gaagaaaaag caacttaccg tgctgatgta aaagcaactc
     8761 ttgctaataa tgatttagca gaattaaaaa attaagaaaa agtaaaagag gtggagggta
     8821 gcaatccttg tcgcccgccc cttttttaat ggagacagaa aaatgatgag tgaattattt
     8881 ggagaatttt tagggacttt aatcctgatt cttctaggaa atggtgttgt tgcaggtgtg
     8941 gttcttccaa aaaccaagag caacagtgca ggttggattg tgattactat gggttggggg
     9001 attgcagttg cggttgcagt atttgtatct ggaaaactca gcccagctca tttaaatcca
     9061 gctgtgacag ttggtgtagc tttaaaaggt gacttgcctt gggcttccgt tttgccttat
     9121 atcttagccc agttcgcagg ggctatgctg ggtcagattt tggtttggtt gcaattcaaa
     9181 ccgcattatg aggtagaaga aaatgcaggc aatatcctgg caaccttcag tactggacca
     9241 gccatcaagg atactgtatc aaacttgatt agcgaaatcc ttggaacttt tgttttggtg
     9301 ttgacaatct ttgctttggg tctttacgat tttcaggcag gtatcggaac ctttgcagtg
     9361 ggaactttga ttgtcggtat cggtctatca ctaggtggga caacaggtta tgccttgaac
     9421 ccagctcgtg accttggacc tcgtatcatg cacagcatct tgccaattcc aaacaaggga
     9481 gacggagact ggtcttacgc ttggattcct gttgtaggcc ctgttatcgg agcagccttg
     9541 gccgtgcttg tattctcact tttctagttt atactcttcg aaaatcaaat tcaaaccacg
     9601 tcagcgtcgc cttaccgtac tcaagtacag cttgcggcta gcttcctagt ttgctctttg
     9661 attttcattg agtattagaa aacaattatg ttgatagagc ttgggcaaga gcccaatttc
     9721 agcaaaaaat gaagtaaatc ttctcataat aaaacgcatc atatcaagca cgaaaattcc
     9781 acgaggtcaa ctacagtcag aaagctgaac aacaagccaa aacgcccaaa aaaggcggca
     9841 aaaagcaagc acctgcaagc aacgtgccga aatagtcaaa ttctgattat gtcaacgaat
     9901 tagacccaaa aatcgttgat atgctagtag aatttcacaa gtcacaaggc actttggaaa
     9961 ctcccgaggc gcaagcagaa atcgcccaaa aacgtgaaga aatcgagcaa aggagagctg
    10021 agcttgagga taaaaaacaa gagcttttga accgcttgaa caaatagagt ttcgcaagta
    10081 ttatgcttac aaattacttg agcaattaac taaaatataa accctgcctt tatatctagg
    10141 cagggtttat attttagaaa ttcacgtagg ttgttacggt ttttacatac ccagtatagt
    10201 ttgagtttct atagtattca gtgataaact tccattttct ttgagcaaca tggatataag
    10261 tacttgttat gtagtatgga tatgggcttt gtgaatccaa gtaagactga taagcttgta
    10321 taccaaaata tgctccacca attattgcac cccatggacc ccccaataaa gcacctatcc
    10381 taccaatcat ataactgatt ccagcaccag tcatgaagtt agcgaatgtg ttagcttgtt
    10441 tattcccatg tattgtgttg acgtaatttc aaacattagg atcgtatgat ctaaaagata
    10501 tatttaggtc gatttcattc ttttgataag ccatataaaa tgccccattg atatagacgc
    10561 cgtcagcacg tcgttcaata gtgtctacac ttccatctgg attgacaacc tcaagaactt
    10621 catcgcttaa aatatttact tgcgtatctc cgaaccgcac tgatgagcca ttctcaaact
    10681 gagcctcacc agatacaact ttagagtttg ccgataagct atcatcagca aaaacaacaa
    10741 gcgacgggga aatgctagac atacagaaaa cagacataac tagcaaacac atgcatttaa
    10801 acatcttaga cataacggaa actcctttgt atttttgatt tttttcaact tttattatac
    10861 aataaaacca aataaaaaga aagcggtaac aatatgctta atgcgaaaat tttttatata
    10921 tttttatgtt tgatcgttat cgaaactaca ggcttgttgt tgttgaaaag aggtctcgaa
    10981 atgggttatt tagacacaga agctattatc ctcgcagttt tttcatttgc tttttacaac
    11041 ctatgttcat tcgcttgggt ctgctctaca ataaaaaaca ataaaaaata aatagacgta
    11101 ttttcaaaaa aaatgcatat ttatcttagt aaaacgacga tttaaatcgt cgtttttttg
    11161 tagtacgacg ggcatgtcgt atatctgagg tgcaagtcct ccgtgggcac ttgctaccgg
    11221 tgaacccaaa agcgattccc aagcctgact atcgtgaggt agcggattaa aacggtctgg
    11281 ggatagaccg ttttaagtct gacgcaggaa ataagaatcg tcagaggaag agatagcgaa
    11341 atcgtggctc tacgaacagg aacgtgatag caaggcgtat atagcggata aggaggcttc
    11401 aaactctaaa gtccaaaaag gtagtcgtaa cctatatgtg taaatcacga gagtaattga
    11461 attcggacta aggtttgtgt gaaaaagata aatctttcta gagtctaaag actctgcgtc
    11521 agatttccta ttttcactgt aaccttttaa cgtcctcata tcttgtataa acgaggaaag
    11581 atgtacgact tatcccgtga ggtttcatga gcgctgaaag cgtagtaaca acgaatcatg
    11641 agaagtcagc cgagcccata gtagtgagga aacttccgta atggaagtgg agcgaagggg
    11701 tgaatactca aacagtctgg ggagagactg tttgaggtct gtcgctagaa agagaaaacg
    11761 acagatcgaa gtaatcctac ttcacttgtg tctgtaaaat gagtggtctg atagaactgg
    11821 actttgacac gtaatgacta gatgaaggtt caccaatata agatgtccct caggcaccaa
    11881 aacaagaaag gaatacgcac atgtcaaaat tgctagataa gatattatca cgcgaaaata
    11941 tgctggaagc ctacaatcaa gtaaaatcca ataaaggctc agctgggatt gatggaatga
    12001 ctatcgaaga gatggataat tatctcagac aaaactggcg cttgactaag gaactgataa
    12061 aacagagaaa atataagcct caaccagttc ttagagttga gattactaaa ccaaacggag
    12121 gtatccgtca actaggaatt ccaacagtta tggatagaat gattcaacag gccattgtcc
    12181 aagttattag ccccatttgt gaaccccatt tctcagatac gagttatggc ttcagaccaa
    12241 ataggtcatg tgaaaaagcc atcatgaagt tcttagagta cttaaatgac ggctatgagt
    12301 ggatagtgga tatagaccta gagaaatttt tcgatacggt tcctcaagat agattgatgt
    12361 ccttggtaca taacattatc gaagacggag atacggaatc cctgattcgt aagtatcttc
    12421 attcaggtgt tatcattaat ggtcagcgtc ataaaacgct agttggcacg ccacagggag
    12481 gaaatttatc tcctctctta tccaatgtca tgcttaatga attggacaag gaattagaaa
    12541 agaggggact tcgatttgtg cgctacgcag atgattgtgt gattacggtc ggaagcgagg
    12601 cagccgctaa gcgtgtgatg tattcagcca gtcgttttat tgagaagcga ctaggtttga
    12661 aagtaaatat gaccaaggct aagattacca gaccaagaga gctgaaatac ttaggttttg
    12721 ggttctggaa atcatcagat ggttggaaaa gtcgtcccca tcaagatagt gttcggagat
    12781 ttaagcttaa attgaagaaa ctaacacaga ggaaatggag tatagactta acaagacgta
    12841 ttgagcaact gaatttgtct attcgaggat ggataaacta tttctcgctg ggaaatatga
    12901 agcgcatagt cgctagcata gatgagcgct tgcgtactcg cctacgagtg attatctgga
    12961 agcaatggaa gaagaaatcg agacgactat ggggattgct taagttagga gttcctaaat
    13021 ggatagcaga taaggtatct ggctggggcg accattatca attagtagct cagaagtcgg
    13081 tacttaaacg tgctatatca aaaccagtcc ttgaaaaacg tggactggtt tcgtgtttgg
    13141 attattacct tgaacgacat gcgttaaaag ttagttgaac cgccgtatgc cgaacggcat
    13201 gtacggtggt gtgagagggg ctagagatta tcccctactc gattaactcc cctgaaattt
    13261 attttaatta tgcaaatttc acgtattttt gatgctgaga cgacgatctg ggaacttttc
    13321 agatattttt ttgactatct aaaatctatc attagaaaag cttagagcgc caaaggattt
    13381 gagcgttttt ctgattttta agactttttc ccagtctctt tttcgattga agatgtaatt
    13441 attctactaa ctaactaact tcttagtact agccaacaac gataatcata attcctccta
    13501 aaattaggaa taataaaggc aatagttttt gttttttcat gtaaaaaacc tcacttttgt
    13561 tttctgctat tttatgctaa aatattaaaa atcaaattta attccaaagt ttgtaactaa
    13621 agggggagcg ctacatgtct aattcatttg tcaagttgtt agtctctcaa ttatttgcaa
    13681 atttagcaga tattttcttt agagtaacaa tcattgctaa catatacatt atttcaaaat
    13741 cagtaattgc cacatcacta gttcctatct taataggaat atcctctttt gttgcgagtc
    13801 ttttagttcc gttggttact aaaaggttag cgctaaatag ggttttatct ttatctcaat
    13861 ttggaaagac tatattattg gcgatactgg taggaatgtt taccgtaatg caatccgtag
    13921 cgcctttggt gacctatcta tttgttgttg caatttccat actagatggt tttgcagcac
    13981 ccgtttccta tgctattgtg ccacgctatg cgaccgattt gggtaaggct aattcagcct
    14041 tatcaatgac tggtgaagct gttcaattga taggttgggg attaggtgga ctcttatttg
    14101 caacaattgg tctgttacct accacgttta tcattttagt cttgtatatc atttctagct
    14161 ttctgatgtt atttcttcct aacgctgaag tggaggtgtt agagtcagaa actaatcttg
    14221 aaattttgct caaaggttgg aagttagttg ctagaaatcc tagattaaga ctttttgtat
    14281 cagcaaattt attggaaatt ttttcaaata cgatttgggt ttcttccatt atacttgttt
    14341 ttgtaacgga gttattaaat aaaacggaaa gttactgggg atattctaat acagcatact
    14401 ctattggtat tataattagt ggcttaattg cttttaggct atctgaaaag ttccttgctg
    14461 ctaaatggga aagtattctt tttcctcttg tagctatggc aatagtgaca ctgactattc
    14521 tatattttcc aaacgcacag atgtttttat tattttcagc tttagttggt atgttatcgc
    14581 aactaaaaga agttcctgaa agtgtatttc ttcaggaaac agtagaggaa aatcatttag
    14641 ttaatgtcta ttccgttctt gaagtgattt ctacattagc attttcagta tttgttttgc
    14701 taatgagcta tattactgag agttttggta ttagcatcag tttttggcta tcagccattt
    14761 gtctgatgat agaagctatt ttaatttata tcagacgaga ttattttaaa tgagagagtg
    14821 gttaaaaagt ctttaaaaat cagaaaagcg catagtatca ggtgttgaaa aaacttgata
    14881 ttgtgtgttt tattatggga agatttactt cattgtctcc tgaaatggag ttttgaagca
    14941 ggatcactct atttgaaaat atacatagaa aaactgtata atccttaaaa taagctgaaa
    15001 tctattggaa acatacggta aacaattgaa aagatactat ataaagtggt acaatggtag
    15061 aaaaataagc tagtaagaat cactcttatt ttagcgaaaa attacagaaa tgaatggttt
    15121 ttcttgatga aacagagaaa agaattgtac ctctttcttg gtcggacagc cttgtatttt
    15181 cttatctttc tagggctgct ttacttcttt agctatcttg gtcagggtca aggaagcttt
    15241 atctataatg aattttaact tgaaggagaa tccctattgt gtcaaataaa ccaatagcag
    15301 atatgattga aaccattgag cattttgctc agacacagcc tagctatcct gtctataatg
    15361 ttttggggca ggaacacact tatggcgatt taaaggctga ttcggatagt ttggctgcag
    15421 tcattgacca actaggcttg cctgagaagt ctcctgtggt tgtttttggt ggccaagaat
    15481 atgaaatgtt ggcaaccttt gtagcgctga ctaagtcagg tcatgcctac attccaattg
    15541 atagccattc ggccttggag cgagtttcag ctattttaga agtagcagag ccaagcttga
    15601 ttattgccat ttcagccttt cccttggagc aggtttctac accaatgata aatctagctc
    15661 aggttcaaga agcctttgcc caagggaaca actatgaaat cacgcatcca gtcaagggag
    15721 atgataatta ctacattatc tttacttctg gtacgactgg taagcctaag ggagtgcaga
    15781 tttcacatga taatctcctc agctttacaa actggatgat tacggataag gaatttgcga
    15841 caccgagtcg tccgcaaatg ctggcacagc caccttattc ttttgacttg tctgtcatgt
    15901 attgggcacc gaccttggca cttggtggta cgcttttcac tcttccttca gtcatcactc
    15961 aggactttaa gcaactcttt gcggctatct tttcattgcc aatcgctatc tggacatcaa
    16021 caccatcctt tgcagatatg gccatgttgt ctgaatactt caacagtgag aaaatgtctg
    16081 gaatcacgca tttctacttt gatggtgaag aattgacggt caaaacagct caaaaactgc
    16141 gcgagcgttt cccaaatgcc cgtatcatca atgcttacgg cccaacagaa gcgacagtag
    16201 ctctgtcagc agttgccgtg acagacgaga tgttagcgac tctcaaacgc ctaccaatcg
    16261 gctataccaa ggctgattct ccaaccttta tcattgacga ggaaggaaat aaactgccaa
    16321 atggtgagca gggagaaatc attgtttctg ggccagctgt ttcaaaaggt tatatgaaaa
    16381 atcctgaaaa aacagcagaa gccttctttg agtttgaagg tctgccagcc tatcacacag
    16441 gcgatgtggg aaccatgaca gatgagggct tgcttctcta cggcggacgc atggacttcc
    16501 agattaagtt taacggttac cgcattgagt tagaagatgt ctctcaaaac ctcaacaagt
    16561 ctcgctttat cgaatctgct gtcgcagtac cgcgctataa caaggaccac aaggtacaaa
    16621 atctattggc ttatgtcatc ttaaaagacg gtgttcgtga gcagtttgag cgagatatcg
    16681 atattaccaa ggccatcaag gaagacctga cagacatcat gatgtcctac atgatgccat
    16741 ctaaattcct ttaccgagac agtttgccac taactccaaa tggaaagatt gacatcaaag
    16801 gattgattaa cgaggtgaat aagagatgat ggagtttttt caacagcttc ctcatttaga
    16861 gccatatggc aatcctcagt attttgttta tgtgattgct gcaaccttgc ccatctttat
    16921 aggcctcttt ttcaagaaac gctttgcctg gtatgaagtg ttggtaagtc tcttctttat
    16981 tgtcaccatg ttggtgggtg gaaagaccaa tcaactagct gccttgggta tttacctttg
    17041 ctgggaaata ttgctcctgc ttttctacaa gcattatcga aaaagcaagg atggcaagtg
    17101 ggtcttctac ttagttagtt ttctgtccct acttccgatt atctttgtca aggtgcaacc
    17161 agctatcaat ggaacgcagt ctttgcttgg gttcttggga atttcttacc tgacctttcg
    17221 ttcggttggg attatcatcg agctgagaga tggagtgatt aaggatttta ccctctggga
    17281 attcctccgt ttccttctct tcatgccaac tttctcgagt ggtccaatcg atcgctttaa
    17341 gcgatttaat gaaaattatc aggctattcc tgagcgagat gagttgatgg atatgctgga
    17401 tgaatctgtc cgctatatca tgtggggctt tttgtataag tttatcctag ctcatgtttt
    17461 aggagagacc ttactacctc ctctgaagaa tttagccttg cagtcaggtg gcttctttaa
    17521 tctctatgcc ttggcagtta tgtatacttt tggtctggag ctcttctttg actttgcagg
    17581 ttattctatg tttgctttgg ccatctcaaa cttgatggga atccgtagcc ctatcaactt
    17641 taacaagccc tttttatcaa gggatttaaa ggagttttgg aatcgctggc atatgagtct
    17701 gtccttctgg ttccgtgact ttgtctttat gcgaatggtg atggtgttaa ccagaaagaa
    17761 agtctttaaa aatcgtaatg taacctcaag catggcctac attgtaaata tgctgattat
    17821 gggattttgg catggtgtga cctggtacta tatcgcctat ggactctttc atggactagg
    17881 cttggtcatc aatgatgcct gggttcgcaa gaaaaaaacg ctcaataagg aacggaaaaa
    17941 agcagggaag gctgccctac ctgagaatcg ctggattcag ttgcttggca tggttgtcac
    18001 tttccatgtt gtcatgttgt cattcttaat cttttctgga ttcttgaata atctatggtt
    18061 taaaaaataa aaggaaataa aatatggata tcaaatcaga agttattgaa attattgatg
    18121 agttgtttat ggaagatgtt tctgacatga tggatgaaga tctttttgat gcaggtgtct
    18181 tggatagtat gggaacggtt gagttgattg tggagattga gaaccgtttt gacattcgtg
    18241 tccctgtaac agagtttggt cgtgacgact ggaatacagc taataaaatc atagctggta
    18301 ttgtggagct acaaaatgct taaacgctta tggatgatct tcggaccggt cttgatcgct
    18361 ggtttgttgg tttttctgct cattttcttt tatcctactg agatgcatca taatctagga
    18421 gctgaaaagc gttcagcagt ggctactact atcgatagtt ttaaggagcg aagtcaaaaa
    18481 gtcagagcac tatctgatcc aaatgtgcgt tttgttccct tctttggctc tagtgaatgg
    18541 cttcgttttg acggtgctca tcctgcggta ttagctgaga aatacaatcg ttcctaccgt
    18601 ccttatcttt taggacaggg gggagctgca tcgcttaacc aatattttgg aatgcaacag
    18661 atgttaccac agctggagaa taaacaagtt gtgtatgtta tctcacctca gtggttcagt
    18721 aaaaatggct atgatccagc agccttccag cagtatttta atggagacca gttgactagt
    18781 tttctgaaac atcaatctgg ggatcaggct agtcaatatg cagcgactcg cttactgcaa
    18841 cagttcccaa acgtagctat gaaggacctg gttcagaagt tggcaagtaa agaagaattg
    18901 tcgacagcag acaatgaaat gattgaatta ttggctcgtt ttaatgaacg ccaagcctcc
    18961 ttttttggtc agttttcggt tagaggctat gttaactacg ataagcatgt agctaagtat
    19021 ttaaaaatct tgccagacca gttttcttat caagcaatag aagatgttgt caaagcagat
    19081 gctgaaaaaa atacttccaa taatgagatg ggaatggaaa attatttcta taatgagcag
    19141 atcaagaagg atttgaagaa attaaaggat tctcagaaaa gctttaccta tctcaagtcg
    19201 ccagagtata atgacttgca gttggtttta acacagtttt ctaaatctaa ggtaaacccg
    19261 atttttatca ttccacctgt taataaaaaa tggatggact atgctggtct acgagaggat
    19321 atgtaccaac aaacggtgca gaagattcgc taccagttag aaagtcaagg ttttaccaat
    19381 atagcagatt tttctaagga cggcggggag cctttcttta tgaaggacac cattcacctt
    19441 ggttggttgg gttggttggc ttttgacaag gcagttgatc ctttcctatc caatcccaca
    19501 ccagctccga cttaccatct gaatgagcgc tttttcagca aagattgggc gacttatgat
    19561 ggagatgtca aagaatttca atagataata taatatagaa gagttcaaga atgaaactag
    19621 ttttcacgtt ttttcttgac tctttttttg cttgtgatat aattaactgg taaacaaaat
    19681 gtcaaagaat agtatttttc tcttaaaaaa gagaagtcta aaaggaaagg agtcagatat
    19741 gagacagcta gcaaaggata tcaatgcttt tttgaatgag gtgattttgc aggcggaaaa
    19801 tcagcatgaa atcctaatag gtcattgcac tagcgaggtg gccctgacca atactcagga
    19861 gcatatcctt atgctcttgt cagaggaatc tttaacaaat tcagaattgg cccgtcgtct
    19921 caatgtcagt caggcggcag ttaccaaggc cattaagtct ttggtcaagg aagggatgtt
    19981 ggaaacatct aaagattcta aagatgcgcg tgtgattttt tatcagttga ctgacttggc
    20041 tcgtccaatc gctgaggagc accaccatca ccatgagcat acacttttaa cctatgaaca
    20101 agtggcgact cagtttactc caaatgaaca aaaagtgatt cagcggtttt tgactgcttt
    20161 agtaggagaa atcaaataat gagatatatt acggtagagg atttgtcctt ctattatgat
    20221 aaggagcctg ttcttgaaca tatcaattat tgtgttgata gtggggaatt tgttaccttg
    20281 actggggaaa atggagcggc taagacgacg ctcatcaagg ctagtcttgg aattctgcaa
    20341 ccacgcattg gaaaggtggc tatttcaaag acaaatacgc aaggtaagaa attgagaata
    20401 gcctatcttc ctcaacaaat tgccagtttt aatgctggtt ttccaagtac ggtctatgaa
    20461 tttgtcaagt cgggtcgcta tccgagaaaa ggctggttcc gtcgtttgaa tgctcatgat
    20521 gaggagcata tcaaggctag tctggactca gttggcatgt gggaacatcg agacaaacgc
    20581 ttggggtctc tatctggggg acaaaagcag cgagcggtaa ttgcgcgtat gtttgcttct
    20641 gaccctgatg tgtttatcct agacgagccg acaacgggga tggatgcagg aagtaaaaat
    20701 gaattttacg aactcatgca ccacagcgcc catcatcatg gcaaggctgt tttgatgatt
    20761 acccatgacc ctgaagaagt taaggattat gcggatcgca atattcatct agtccgtaac
    20821 caagactcgc catggcgttg tttcaatgtt catgagaatg gccaggaggt gggccatgct
    20881 tagtttatta tcttacgact ttatacagcg cgcctttttg gcggttattg ctatgagtct
    20941 tttctcaccg gtattgggaa ccttcctcat cttgcgtcgt cagagtttga tgagtgatac
    21001 ccttagccac gtctcacttt caggtgtagc ctttggtctg gttttgggga tttctccaac
    21061 tgtttctact attgccattg tcttgattgc ggcggtcttt ctggagtatc tccgtacggt
    21121 ttacaagagc tttatggaaa tcgggacagc tatcctcatg tcaacaggtc tggctgtttc
    21181 tctgattgtc atgagcaagg gtaaaagctc gagttcaatg agtttggacc aatatctctt
    21241 tggttcgatc gtgactatca gtgaagaaca ggtcatttcc ctctttgtca ttgcggcggt
    21301 tgttttgatt ttgacctttc tctttcttcg tcctatgtat atcttaactt ttgacgaaga
    21361 tacggccttt gtggatggct tgccagttcg taccatgtcc attcttttta acatggtgac
    21421 aggggtggct attgccctta tgattcctgc agcaggagct cttctggtat cgaccattat
    21481 ggtcttgcca gctagtattg ccctgcgtct ggggaaaaac tttaaatcgg ttatgctgct
    21541 tgccagtgcg attggctttt tgggaatggt agcaggactt tacatttcct actatgcaga
    21601 aacacctgca agtgcaagta ttaccattat ttttgtaact gtctttatac taatcagttt
    21661 agtaagacgt tttatcaaat aggagacgaa cgtgaaaaaa attagcttat tactagccag
    21721 tctatgtgcc ttgtttttag tggcttgttc caatcaaaaa caggcagatg gtaaactcaa
    21781 tatcgtgaca accttttacc ctgtctatga atttaccaag caagtcgcag gagatacggc
    21841 taatgtagaa ctcctaatcg gtgctgggac agaacctcat gaatacgaac catctgccaa
    21901 ggcagttgcc aaaatccaag atgcagatac cttcgtttat gaaaatgaaa acatggaaac
    21961 atgggtacct aaattgctag ataccttgga taagaaaaaa gtgaaaacca tcaaggcgac
    22021 aggcgatatg ttgctcttgc caggtggcga ggaagaagag ggagaccatg accatggaga
    22081 agaaggtcat caccatgagt ttgaccccca tgtttggtta tcaccagttc gtgccattaa
    22141 actagtagag cacatccgcg acagcttgtc agcagattat cctgataaaa aagagacctt
    22201 tgagaagaat gcagctgcct atatcgaaaa attgcaagcc ttggataagg cttacgcaga
    22261 aggcttgtct caagcaaaac aaaagagctt tgtgactcaa cacgcagcct ttaactatct
    22321 tgccttggac tatggactca aacaagtcgc aatctcagga ctttctccag atgcagagcc
    22381 atcagctgct cgcttggcag aattgacaga gtatgtcaag aaaaataaaa tcgcctatat
    22441 ctattttgaa gaaaatgcct cacaagccct tgctaacaca ctttcaaaag aagcaggtgt
    22501 caaaactgat gtcctcaatc ctttagaaag tctgacagaa gaggacacca aggctggaga
    22561 aaactacatt tccgtgatgg agaaaaacct caaggctttg aaacaaacaa cagaccaaga
    22621 aggcccagca atcgaacctg aaaaggcaga ggataccaag acagtccaaa atggttactt
    22681 cgaggatgca gctgtcaagg accgcacctt gagtgactat gcaggtaact ggcaatcagt
    22741 ttaccctttc cttgaagacg gcacgtttga ccaagtcttt gactacaagg ctaagttgac
    22801 tggtaagatg acccaggctg agtacaaggc ttactataca aaaggctatc agacagatgt
    22861 gactaagatt aacattactg ataatactat ggaatttgtt caaggtggac aaagcaagaa
    22921 atacacttac aagtatgtcg gtaagaaaat tttgacttac aagaaaggca atcgtggcgt
    22981 gcgtttcctc tttgaagcca cagatgctga cgctggacaa ttcaaatatg ttcagtttag
    23041 tgaccacaat gttgccccag ttaaggcaga acatttccat atcttttttg gaggtacaag
    23101 ccaagaagct ctatttgaag aaatggataa ttggccaacc tactacccag ataacctatc
    23161 tggccaagaa atcgcccaag aaatgttggc gcattgatga gaaatcgact agttcataag
    23221 agctagtcgg ttttttgata ctagatggct aacttcatta tagacctttc agaactaagg
    23281 gaacctgaaa aaataaataa aactcttgaa atatctggac ttatatgcta gaatgtagtt
    23341 agtgtataag gttcattaga acaccaaagc ccctaactag tgccatagtt aagggctttt
    23401 ttgacgtatc ttagcgattt aatgggtgtt tataggctag tcagtcggtc tacttcttac
    23461 catctagcca tttgcagacg aaatacaaga taattccagc tataacatct gctataatag
    23521 taagagcaag ctctggtata aggctcatta gtttcacctc ctctcacgaa cccataggaa
    23581 cgtaatcggt aaccgatgac aaaaatagta taccacacta aatttagatc atcaacctca
    23641 cttaatactt gaactattgt agattatatg ctaaaatgtg gttaattgat aaggttcatt
    23701 agaacaccaa agcccctaac tatggccgta gttaagggct tttttgacgt atcttagcga
    23761 tttaacgggt gtttataggc tagtcagtcg gtctactcct tactatctag ccatctgcag
    23821 acgaaataca agataattcc agctataaca tccgctataa tagtaagagc gagctctatg
    23881 ataaggctca ttagtttcac ctcctctcac gaacccatag gaacgtaatc ggtaaccgat
    23941 gacaaaaata gtataccaca atacatttag atcatcaagg tcacttaatt cttgaaatat
    24001 agggtctagg cgacaaagtc tttaaaatca gaaaaacgca taatatcagg tgtgcaaaaa
    24061 cttgatacta tgcgttttat tgtgggaagg tttactccat tttctcctga aattgagttt
    24121 ttgtccagcc tctgttttta gaattgctaa gaaaataatg tcatgtggtg aatatttgta
    24181 aatcagtcag cagacagaac gaatactctt cgaaaatctc ttcacatcat gtcagcttcg
    24241 tcttgccgtg tccatggggg acttgacttg atcagttttc aaatctgtac tttgagcaag
    24301 ctgagactag cttcctattt gattttcatt gaatatcaga aacccattct ccatcaaata
    24361 attcgactgc gtctaataat ttttggtctg gcaaggtgtc agaaataaag gttgtgtatt
    24421 tggagagggg attaatttta aaaaatccag tcttgtaaaa tttagaacta tcaatcagta
    24481 agatggtttc atgggctttg tcaataatat tcttttttga aatagcttgg ctgagagaag
    24541 cttcataaac atattggtca tcaatacctc ttgctgaaca aaatgctaaa tcgatattaa
    24601 aatgatctaa taaagaattt tccttatcat agttgaccac ggaacaggat tgatgtttga
    24661 cctcgccaga tgtgataaag attttggagc tatctttaac agtttcagat agggtttgtg
    24721 cagtatgtaa accatttgta aaaataatca aattatcaag ttcagaaaga tagggacaaa
    24781 gttcgtagac agtcgtactg gaatccagat aaatacacat gcctgaccga ataaagtctt
    24841 tagcgagact agcgattagt cttttttgcc tagtactttc tccttcccgt atttgatgag
    24901 aaagttcaat tgtgttcata gaggacaggg tcacgtatcc gtgctttctt ttgataagac
    24961 cttgattttc taagaaaatt aaatcacgac gtaaggtact tgtgctggag aaagtgattt
    25021 ctgccagctc ttttacggca attctttttt tctttttgat gatttcaatc aattcaagta
    25081 cacgttcatc ttttatcata agctcctcct aatttatcat ttcaactata ttatagcaca
    25141 aattggagga atttgaatta tttttatgaa tattgggtta acatttgaac attattcaag
    25201 taagcgttca catattgaaa aaataaaacg tggggattat aataaagtta atcaaggacg
    25261 aagagagaag aaaaatggaa gcggttttag caatagattt aggtgcgact tctggaagag
    25321 caatcgttgg ttacctttct gaaaataaac tagtaatgga agaaataaat cgcttttcta
    25381 atctacctat tagagtaaaa gggcatttat cttgggatgt tgactttcta ctagctaaaa
    25441 ttcttgaaag tatccgcttg gctaatacta gttacaagat tttatctatc ggtattgaca
    25501 catggggagt tgattttgga ctgattgata atgaaggtaa gctgttatca caacctgttc
    25561 attatcgtga tgaaagaaca aagggattgt taaaggaaat atctgaaatg actgaattag
    25621 aaaaactgta ttcagagaca ggaaatcaga ttatggagat aaataccttg tttcaactct
    25681 ttaaggcacg tcaagaatct cctgactctt tctataagac caataagatt cttttaatgc
    25741 cagatttgtt taattatctc ttgacaggta agtttgctac agaaaaaagc attgcttcaa
    25801 caactcaatt atttgatcct aggagtcaaa actggaatca gaatatctta aaactatttg
    25861 aattggattc atctttactt cctgagattg tttcagaggg aaatgttctt ggaaggataa
    25921 aaaaggagta tggtttaggc gatattcctg ttgtgaatgt ttgtagtcat gatacagcaa
    25981 gcgcgattgt ctcagtacct aagacagaag gtagtttatt tatttcatca ggtacttggt
    26041 ctttggttgg agtggaactt acttcaccgc ttcttactac cgaatccttc agttatggat
    26101 ttacaaatga agtcggtaaa gatggagtga ttacatttct gaagaattgt acagggttgt
    26161 ggatcataga ggaactaaga cgttcatttg aacgaagagg gaaagcctat tcttttgatg
    26221 atattaggac aatggtggag aaagaaaaag aaaatcttcc tctgattgat actgaatcaa
    26281 ctgaatttgc aacagaatct gatatgcaca agactttgac agaatatcta gcttatcatc
    26341 atgaaactag agagtggaca gatggacaac tatttaagat tgtttatgaa agcctagctg
    26401 aaacgtatag gaaagcgata gagttactag aagaactaac tcataaggtt tataagagga
    26461 tatatgtgat tggaggaggt gctagagcca gttactttaa ccaaatgatt gctgatagaa
    26521 ctggtaaaga ggttcttaca ggtttgactg agggtacagc tgtggggaat attgttgtgc
    26581 agctattgag tcaaggtaaa ataaacgagg atacagagtt aaaggatatt atgacaaata
    26641 ttgctgagac acaatattat tatcctcagc tatcataaac aaaaataaaa aaacggaggt
    26701 tttgtcatga acaaaaaaag tcttttgaaa tgcgctgtta tcgggttagt agctaccttt
    26761 ggtttagcag cttgtggaac atctaaggat gcaagcggtg gaagttcttc tggtaaagaa
    26821 gtattagaat tttatcatgg gtatcatcat agtgaagatg aatggcctgt agcgaagact
    26881 atgcgagatt tatatgataa atttgcagaa gaacataaag atagtggtgt agaatttaaa
    26941 ccaactcctg taaatggtga tttgaaggat ataatgaata acaaggttgc tagtggtgaa
    27001 tttcctgatg tgattgacct agcaggtaat gcagtatcat tagctgcgat tgaacaaaaa
    27061 cttgttttag atttgaaacc atatatcgat tcaaataagc ttgaaaaaaa tgttggtttg
    27121 aactataagc aaaaccaaaa agatggaaaa atttatacag ttcacgaaca gttatttaca
    27181 atgggtttgt ggtacaacaa ggacatattt gcaaaagcgg gtgctaagac acctgatcag
    27241 tggaatactt gggatgattt cactcaggca atggcaagca ttagaaaaca agatggagtg
    27301 tatgcatttg gtgctggaga accatctatt cgcttgttta atacagtatt aggaaccaca
    27361 gaaaatggac gtaaattatt agataaacca ttaacaaaag aaggaattga atctaaagaa
    27421 tttgcagatg ctttgaaaat ggttatgaaa gaaattcaag ctaatggttc taagaatgct
    27481 ggtggcgatg ccaatgctta ttccaaagat ttccaagaag gtaaatctgc agtattcttt
    27541 aatggtgtgt gggcttctgg tgagatgtct aagaacccaa gtcttgcacc aaaaaggata
    27601 taaaattttt ttaaaaaatt tttcaaaaaa tatacaaatg accaaaaagt gtccaattat
    27661 catctggtta tcacttggat ctgtataaag agaaatgttt gtgtgaaagg ataaaaagat
    27721 gcaacattct tttgaagata gattttggag aagcatttct tgttcaattg tacaaattat
    27781 agaatctttt ctgagtattt aggaagagat aattatctta ttgaccctct ttttattttt
    27841 tgttatagtc gacgaggtga tagcttagaa taatcactta ttcacaatct gtggaaaagt
    27901 ctggatagtg aatggtcttc acacaatgac ctgaaagaag cctgagaata attatggaga
    27961 gtagcattct gagaggtgtt agcagaacca tatgacagag ctgtttgaag agggaatatt
    28021 gaggagaaaa atcctgagcc taccagttgg agttggaaag agctggctgt tagatcatgg
    28081 tttattatcc acaacctgtg gataaccttg tgaacaagag aagttgctaa agaaggagat
    28141 atataacgat gaagaaaatc aaaccgcatg gaccgttacc aagtcagact cagctagctt
    28201 atctgggaga tgaactagca gcttttatcc acttcggtcc taataccttt tatgaccaag
    28261 aatgggggac tggacaggag gatcctgagc gctttaaccc gagtcagttg gatgcgcgtg
    28321 agtgggttcg tgtgctcaag gaaacgggct tcaaaaagtt gattttggtg gtcaagcacc
    28381 acgatggctt tgtcctttat ccgacagctc acacagatta ttcggttaag gtcagtcctt
    28441 ggaggagagg aaagggcgac ttgctccttg aagtatccca agctgccaca gagtttgata
    28501 tggatatggg ggtctacctg tcatcgtggg atgcccatag tcccctctat catgtggacc
    28561 gagaagcgga ctacaatgcc tattatctgg ctcagttgaa ggaaatctta tcaaatccta
    28621 actatgggaa tgctggtaag ttcgctgagg tttggatgga tggtgccaga ggagagggcg
    28681 cgcaaaaggt taattatgaa tttgaaaaat ggtttgaaac cattcgtgac ttgcagggcg
    28741 attgtttgat tttttcaaca gaaggcacca gtatccgctg gattggcaat gaacgagggt
    28801 atgcaggtga tccactgtgg caaaaggtga atcctgataa actaggaaca gaagcagagc
    28861 tggactatct tcagcacggg gatccctcgg gcacgatttt ttcaatcgga gaggcagatg
    28921 tttccatccg tccaggctgg ttctaccatg aggatcagga tcctaagtct ctcgaggagt
    28981 tggtcgaaat ctactttcac tcagtagggc gaggaactcc actcttgctt aatattccgc
    29041 cgaatcaagc tgggctcttt gatgcaaagg atattgaacg actttatgaa tttgcgacct
    29101 atcgcaatga gctctataaa gaagatttgg ctctgggagc tgaggtatct ggtccagctc
    29161 tttccgcaga ctttgcttgt cgccatttga cagacggcct tgagaccagc tcttgggcaa
    29221 gcgatgcaga cttgcccatc cagttagaac tcgacttagg ttttcctaaa acttttgatg
    29281 taattgagtt aagagaagat ttgaagctag ggcaacgaat cgctgctttt catgtgcaag
    29341 tagaggtgga tggtgtctgg caggaatttg gcaggggctt cacagttggt cataagcgcc
    29401 tcttgcgagg tccgctagta gaggcacaaa aggtgcgcgt gatgattacc gaggcacaat
    29461 ctattcctgt attgaccaag atttcccttt ataaaactcc tggattatca aaaaaagaag
    29521 ttgttcagga actagcattt gcagaaaaaa gcctagctgt ggcaaaggga gaaaatgcct
    29581 attttacagt taagcgcaga gaatgtagtg gtcctttaga agctaagatt tcgattcaac
    29641 cggggacagg tgtccatggt gtcgcctatc aggacgagat ttatgtcctt caattccaag
    29701 caggggaaag caaaaaagat ttgcatctac caaccctgta tttcgcagga gataaaacct
    29761 tggatttcta tctgaaccta acggtggatg gtcagcttgt ggatcaactt caagtccaag
    29821 tttcataaaa gaagaacctt tgcgcgatgc aaaggttctt ttggttatta gtgacttggt
    29881 agccagctga gggtgaaagt tagttgttca gcttttaaga ggtcttggtg ttgaatagtt
    29941 gatacgagtg ttttgttcag tcggcattct ttgacaaagt taaaatggtt gtggttttgt
    30001 ttagtatgga tatccagcca tttatcttct ttagctaggt agactcgtag atggtcaaag
    30061 agagggattc cgaggtcata gcttggtttt cctggacagg ttggataaaa tccgagagct
    30121 gaccagatgt accaagcaga gagactacca ttgtcttcat ctccaggata ggcttcccaa
    30181 cttgggtgaa aagctttctg acggagcgtc ttgataagaa gggcagtgta gtcagggtaa
    30241 tcgctgtagc ggaagagata agggatgtgg aaactaggct ggttggaaat ggctatttgt
    30301 ccaaaaggag cagtagccat ctcgctcatt tcgtgaattt cataaccata gcctgttgtt
    30361 tcaaagaggg gagcatcttg acaagctttc aaaagatagt tgctaaaggt ttcttttcca
    30421 cccataagtt ggattaagcc agggatgtcg tggagaacgc ctaaagtagc ttgaatggca
    30481 gagcattcag cgtagtctcg cccccaacta taaggagaga agtcagggtg aaagtttcct
    30541 tgattgtctc gtgctcgcat gtaacctgtc tcagcgtcaa atagctggcg gtaattttgt
    30601 gaagcagcct tgtaggtttc agcgatttct atgttctcta gttttttggc acagctagcg
    30661 atacaaaagt cactataggc atagtctaga gtatggctaa cactttcgtg gtggtcggta
    30721 gagaggtaac ctagttcttg gtattgggct agtccgtggc ggccattgat tccgagaggg
    30781 tcggctttgc tggctgtttc gagcatggct tggaagagtt ctccttctag gtcaggggcc
    30841 atgtccttgc aggcgctatc tgcgataata ccgtctaaaa gtgtacctgg catcataccc
    30901 cgttcatctg gagccagcca ttttggaagg aaaccagtat cgcggtagct attgaggaaa
    30961 ccttctaaaa agcgttgata gtgctccggt atgataaggg caaagagggg gaaggtggtg
    31021 cggaaggtat cccagaaacc attgttgcta aagaggacac caggcttgac agtaccagta
    31081 gccagatcca tgtggatggc ttgccctgac tcatcaacct cataaaaagt ctgtgggaag
    31141 aggaagagtc tgtagaggca gtggtcaaag aaggttcggt cagcctctcc tgtctctata
    31201 atgtcaaaac gatggaggag attttcccaa tccgcttggg cacttgtttt acagctatca
    31261 aaatcttctt gaggtagatt gattagagct tgagaaggag agatgaaaga agtggctagt
    31321 tgcatctcgg tttgactact tgctaagtca attcgccagt ctccagcttc ttggctgata
    31381 gcaagaatat ccgtgttcat ttgcagggca gtgaagagca tcagtggatt tttattggtc
    31441 tctgttttcc cttcttgtct gagagcaaga gttcgcttat ctacttgctc tactgtcagt
    31501 tcatctgctg cgtgaagata gagggagagg gctttgcctt gcttttgatt caaacgaata
    31561 gaagcaccat agcaagtcgg tgtgagctgg gtttcaatct gataacgcag agaaaagagc
    31621 ttcaaatagt gaggctggaa gcaagcttta tctatatcat aagaagactg gcggtgaaag
    31681 aggctgtctc cccccagttg actggtgaca ggtgtcagaa ggagccaaga gtagtcccca
    31741 atccaaggac tgggctggtg agttaatcga atcccctgaa agataggcag atgcggatca
    31801 aaaaaccaag atccaccctg gtcactggtc tggggcacaa agtaattcat ccccaaaggc
    31861 acgcctgtgt atggcagggt atttccccga gagaaggcat gcttgctagc agtaccaaag
    31921 cgggtatcga tggtttcaag tagtggtttc atagtctttc ctttagctgt ttttctacat
    31981 tatatcagaa aaagagggcc tttagaaaag gagtttcaaa aataattatt ttgtagaaaa
    32041 atgactatca tttgtgtatg tattttctgt ctcaaaagct atatactgaa catgaaactt
    32101 gtttgaaaga gggaattgca cgatgattta ttcgaaagaa attgttagag aatggctaga
    32161 tgaagtagca gagcgggcta aggaccatcc agagtgggtg gatgttttcg agcgttgcta
    32221 caccgatacc ttggacaata cggttgaaat cttagaagat ggttcaactt ttgtcttgac
    32281 tggggatatt cctgccatgt ggcttcgaga ttcgacagcc caactcagac cctaccttca
    32341 tgtagctaaa agagatgccc tcctgcgtca gaccattgca ggtttggtca aacgtcagat
    32401 gaccttggta ctcaaggatc cctatgctaa ctccttcaac attgaggaga actggaaagg
    32461 gcaccacgag actgaccaca cagaccttaa cggctggatc tgggagcgca agtatgaggt
    32521 ggattcgctt tgctatcctt tgcagttggc ttatctcctc tggaaagaga ctggcgagac
    32581 tggtcagttt gatgagactt ttgtcgcagc gactaaggaa attctccatc tgtggacggt
    32641 ggaacaagac cacaagaact ctccttatcg ttttgtccga gatacggacc gtaaggaaga
    32701 caccttggta aatgatggct ttggacctga ctttgcagtg acaggtatga cttggtcagc
    32761 ctttcgtccg agcgatgact gctgtcagta tagttacttg attccgtcaa atatgtttgc
    32821 tgtagtagtc ttgggttatg tgcaagaaat cttcgcagca ttaaacctag ctgatagcca
    32881 gagtgttatt gctgatgcca agcgtcttca ggatgaaatc caagaaggaa tcaaaaacta
    32941 cgcttacacc accaacagca agggcgaaaa gatttacgct tttgaagtgg atggcctagg
    33001 aaatgccagc atcatggatg atccaaatgt accaagtcta ctagctgcgc cctatctggg
    33061 ctactgttcg gtcgatgatg aagtgtatca agctactcgt cgtaccattt tgagctctga
    33121 aaatccatat ttctaccaag gagaatacgc tagcggtcta ggaagttctc ataccttcta
    33181 tcgctatatc tggccaatcg ccctttctat ccaaggattg acaacaagag ataaggcaga
    33241 gaaaaaattc ttgctggatc agctggttgc ctgcgatggt ggtacaggtg tcatgcacga
    33301 aagcttccac gtagatgatc cgaccctcta ctctcgtgaa tggttctctt gggctaacat
    33361 gatgttctgt gagttggtct tagattactt ggatattcgc taaggggctc gctttagctc
    33421 aaccgattct tatcagaatc acaagtttac atttaaaacg ttaaaattta aatttagaat
    33481 gaggttttac ttcatggaaa atattgttgt acatattatc tcacatagtc actgggaccg
    33541 tgagtggtac ttgccttttg aaagccatcg tatgcagttg gtggaattgt ttgacaatct
    33601 ctttgatctc tttgaaaatg accctgagtt caagagtttc cacttggatg gacaaactat
    33661 tgtccttgac gactacttac aaattcgccc tgaaaatcgt gacaaggtcc aacgctacat
    33721 tgacgagggc aaacttaaaa ttggtccctt ttacatcttg caggatgact acttgatctc
    33781 cagtgaagcc aatgtccgca ataccttgat tggtcaacaa gaagctgcca aatggggtaa
    33841 atcaacccag attggctact ttccagatac ctttggaaat atgggacaag cgcctcaaat
    33901 tcttcaaaaa tcaggcattc acgtggcgac ctttggtcgt ggtgtgaagc cgattggatt
    33961 tgacaaccaa gtccttgaag atgagcagtt tacatcccag ttttcagaaa tgtactggca
    34021 gggtgtggat ggtagtcgtg ttttaggtat tctctttgcc aactggtaca gtaacgggaa
    34081 tgaaattcca gttgacaaag atgaggcctt gaccttctgg aaacaaaaat tgtcagatgt
    34141 gcgtgcctac gcttcgacca accaatggtt gatgatgaac ggctgtgacc accagcctgt
    34201 acagaaaaat ctgagcgaag ccattcgtgt ggcaaatgaa ctcttcccgg atgtaatctt
    34261 tgttcatagt tcttttgatg aatatgttca agctgtagaa ggtgcgcttc ctgaacactt
    34321 atcaactgtt acaggcgagt tgaccagtca ggaaacagat ggctggtaca cacttgccaa
    34381 cacttcttca tcccgtattt acctaaaaca agccttccaa gaaaatagca acctcctaga
    34441 gcaagtggta gaacccttga ctattatcac tggtggacac aaccacaagg accagttgac
    34501 ctatgcttgg aaaacacttt tgcagaatgc gccacatgac agtatctgtg gctgtagcgt
    34561 ggacgaagtt caccgcgaga tggaaacgcg ttttgccaag gtcaaccaag taggaaactt
    34621 tgttaaaagt aatttgctca acgagtggaa gggtaaaatt gctacggata aggctcaaag
    34681 tgactatctc tttactgtca ttaacacagg cttgcatgat aaggtcgata ctgtcagcac
    34741 agtgattgat gtggcgactt gtgatttcaa ggaattgcac ccaacagaag gctacaaaaa
    34801 gatggctgct cttatcttac caagttaccg tgtggaggac ttggatggtc gtcctgtaga
    34861 ggctacaatc gaagacctcg gagctaattt tgagtacgat ttaccaaaag acaagttccg
    34921 ccaagctcgt attgctcgac aagtgcgcgt gaccattcca gttcacctag cgccgctttc
    34981 ttggacaacc ttccaattgc tggaaggaaa acaagaacac cgtgagggta tttaccaaaa
    35041 cggagtgatt gatacaccat tcgtaacggt gagtgtggat gacaatatca cagtatatga
    35101 caagacaact cacgaagcct atgaagactt tatccgcttc gaagaccgtg gggacatcgg
    35161 aaacgagtat atctatttcc aaccaaaagg aacagagcca atctttgcag agcttaaggg
    35221 ccacgaggtc ttggaaaaca cagatcgcta tgctaaaatc ttgctcaaac atgaattgac
    35281 cgtgcctgtc agtgcggatg aaaagctaga agaagagcaa caaggtatca tcgagtttat
    35341 gaagcgtgag gctggacggt cagaagaatt gacaaacatt cctctggaaa ctgagttgac
    35401 tgtcttcgtt gacaatccac aaatccgctt caagactcgc tttactaaca ctgccaagga
    35461 tcaccgtatc cgtctcttgg tcaagactca taacacgcgt ccaagcaatg attctgaaag
    35521 tatctatgag gtggtgacac gaccaaacaa accagctgct tcatgggaaa atcctgaaaa
    35581 tcctcaacac caacaagctt ttgtcagtct gtatgacgat gaaaaagggg tgactgtatc
    35641 caataaggga ttgaatgaat acgaaatcct tggggataac accattgccg tgaccatttt
    35701 gcgtgcatca ggtgagctag gtgactgggg ctacttccca acgccagaag cacaatgctt
    35761 gcgtgagttt gaagtcgagt ttgcacttga atgccaccaa gcccaagaac gcttttcagc
    35821 tttccgtcgt gccaaagcct tgcagacacc gtttaccagc cttcagcttg ctagacagga
    35881 aggaagcgtg gttgcgactg gtagcctctt gagccattct gttctcagca taccgcaaat
    35941 ttgtccaaca gcctttaaag tggcggaaaa tgaagaagga tatgtcctcc gttactataa
    36001 tatgagtcaa gaaaatgtgc gcatatcaga acatcaacaa accattcttg acctacttga
    36061 acgaccatac ccagttcatt caggactatt ggctccacaa gaaattcgta cagaattgat
    36121 taaaaaagaa gaaatctaat ttcaaaaagt aaacataaag agaaaggagg ggcgaaagag
    36181 taagaactaa ctgctgattc gccccttttt atggtaaaaa caatgaccat tgcaacgatt
    36241 gatatcggag ggactggaat taagtttgcc agtctgactc ctgatggaaa aatactgaat
    36301 aagacaagca ttccaacgcc tgaaagcttg gaggatttac tagcttggct agaccagcgc
    36361 ttgtcagagc aggattacag tgggattgct atgagtgttc caggtgcggt caatcaagag
    36421 acaggtgtga ttgatggctt cagtgcggtg ccctacatcc atggcttttc ttggtatgag
    36481 gcgcttagct cttatcagat tcctgtccat ctggaaaatg atgccaactg cgttggactc
    36541 agtgaattac tggctcatcc agaacttgaa aatgcagcct gtgtcgtgat tgggacaggg
    36601 attggtggag ctatgattat caatggcaga ctgcaccgag gtcgccacgg cttgggtgga
    36661 gaatttggct atatgacaac ccttgcccct gctgaaaagc tcaacaactg gtcgcaacta
    36721 gcgtcaactg ggaatatggt tcgctacgtg attgaaaaat ctggtcagac tgattgggac
    36781 ggtcgcaaga tttaccaaga agctgcagct gggaatgcca tttgccaaga agccattgag
    36841 cgcatgaacc gcaatttggc gcaaggcttg ctcaatatcc agtatctgat tgatccagat
    36901 gtcatcagtc tgggaggctc tatcagtcaa aatccagatt ttattcaagg tgtcaagaag
    36961 gctgttgaag actttgtcga tacttacgaa gaatatacgg tcgcacctgt tatccaagcc
    37021 tgcacctatc atgcagatgc taatctctac ggtgcccttg tcaactggct acaggaggaa
    37081 aaccaatggt aagatttaca ggacttagtt ccaaacaagc gcaagctatt gaagtattaa
    37141 aaaatcacat ttctctgcca gatgtggaag tggctgttac tcagtctgac caagcctcta
    37201 tctctatcaa gggtgagggt ggccactatc aattgaccta ccgcaagcct caccaacttt
    37261 atcgttcctt gtccctgttg gtaacagctc ttgcagaagc tgataaagta gagattgagg
    37321 aacaggcagc ttatgaagat ttagcctaca tggcagactg ttctcgaaat gcggtgctga
    37381 atgtggcttc tgccaagcag atgatagagg tcttggctct catgggctac tcaacctttg
    37441 agctctacat ggaagacact taccagattg aagggcagcc ttactttggc tatttccgcg
    37501 gggcttattc ggctgaggag ttgcaggaaa tcgaagccta tgcccagcag tttgacatga
    37561 cttttgttcc ttgtattcag accttggccc acttgtcggc ctttgtcaaa tggggtgtca
    37621 aggaagtgca ggagctccgt gatgtagagg acattcttct cattggcgaa gaaaaggttt
    37681 atgacctgat tgatggcatg tttgccacgt tgtctaaact gaagactcgc aaggtcaata
    37741 ttgggatgga cgaagcccac ttggttggtt tgggacgcta cctgattttg aacggtgttg
    37801 tggatcgtag tctcctcatg tgccaacact tggagcgcgt gctggatatt gctgacaaat
    37861 atggtttcca ctgccagatg tggagtgata tgttcttcaa actcatgtca gcggatggcc
    37921 agtacgatcg tgatgtggaa attccagagg aaactcgtgt ctacctagac cgtctcaaag
    37981 accgtgtgac tctggtttac tgggattatt atcaggatag cgaggaaaaa tacaaccgta
    38041 atttccgcaa tcatcacaag attagccatg accttgcatt tgcaggggga gcttggaagt
    38101 ggattggctt tacacctcac aaccatttta gccgtctagt ggctatcgag gctaataaag
    38161 cctgccgtgc caatcagatt aaagaagtca tcgtaacggg ttggggagac aatggtggtg
    38221 aaactgccca gttctctatc ctaccaagct tgcaaatctg ggcagaactc agctatcgca
    38281 atgacctaga tagtttgtct gcgcacttca agaccaatac tggtctaacg gttgaagatt
    38341 ttatgcagat tgaccttgcc aacctcttac cagacctacc aggtaatctc agtggcatca
    38401 atcccaaccg atatgtcttt tatcaggatg ttctctgtcc gatacttgac cgacacatga
    38461 cacctgaaca ggacaagcca cacttcgctc aggcggcggg aactattgct gacattaaag
    38521 aaaaagctgg aaactatgct tatctctttg aaactcaggc ccagttgaat gctattttaa
    38581 gtagcaaagt agatgtggga cgacgcattc gtcaggccta ccaagcggat gataaagaaa
    38641 gtttacaaca aatcgccaga caagaattac cagaacttag aagccaaatt gaagacttcc
    38701 atgccctctt tagtcaccaa tggctgaaag aaaacaaggt ctttggtttg gatacagttg
    38761 acatccgtat gggcggactc ttgcaacgca tcaaacgagc agaaagccgt atcgaggttt
    38821 atctggctgg ccagcttgac cgcatcgacg agctggaagt tgaaatccta ccatttactg
    38881 acttctacgc agacaaggat ttcgcagcaa ctacagctaa ccagtggcat accattgcga
    38941 cagcttcgac gatttatacg acttaatact cttcgaaaat ctcttcaaac cacgtcagct
    39001 tccatctaca acctcaaaac agtgttttga gcagcctgca gctagcttcc tagtttgctc
    39061 tttgattttc attgagtata aaaacaagaa caccttgctt ggcgcagggt gtttcgcgtg
    39121 aaacagaaga attatctggt ttcaaatgct acagttagac aaacttatga taaaatagca
    39181 gaaagtgaat gtttcctaag agcaattcta tcgatgagca attggaggta ttatgctaca
    39241 cttaaaatta gtaaaacaag aaatagaagc tgaaaagcca gcatctgtag aagcctgggt
    39301 catttccgtc aaatttaaaa aaggttgcta ccgacatata tagattccaa aaacaaaaac
    39361 gttagcggaa ctagcagatg tgattttatg gagtttcgat tttgtaaatg ctcatgctca
    39421 cgcatttttc atggataatg ttgagtggag tcatgcagat tcttactttc ttagctttgt
    39481 tagtgacgat gttgaagaac gttacacaga aaatgtctat ctggatagcc taagtgtcaa
    39541 acaaaaattt aagtttattt tcgacttcgg tgatgaatgg cgttttgaat gccaagtgct
    39601 gagagaaatc gagacagagg acgaagaagc ttatctcgta cgttcggttg gaacgtcgcc
    39661 agaacaatat ccagattatg atggttttga ctatgaagaa tggtaaaatt gaaatctaaa
    39721 aaacaattgg aatcagtctg tgtaggctta gtatttcaat agacttcctg caaaactaga
    39781 atcctagttc atgattgata atacc
//
LOCUS       DBERMM010000016        38706 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.016, whole genome shotgun sequence.
ACCESSION   DBERMM010000016 DBERMM010000000
VERSION     DBERMM010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 38706)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 38706)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..38706
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.016"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            371..598
                     /locus_tag="ACL8AS_001059"
     CDS             371..598
                     /locus_tag="ACL8AS_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228934.1"
                     /translation="MIFKAFKTKKQRKRQVELLLTVFFDSFLIDLFLHLFGIVPFKLD
                     KILIVSLIIFPIISTSIYAYEKLFEKVFDKD"
     gene            886..3783
                     /gene="nanA"
                     /locus_tag="ACL8AS_001060"
     CDS             886..3783
                     /gene="nanA"
                     /locus_tag="ACL8AS_001060"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored neuraminidase NanA"
                     /protein_id="HGS1228935.1"
                     /translation="MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASE
                     QPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLEN
                     VETVIEKEDVETNASNDQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSS
                     ATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAE
                     LPNGRVRLYVNGVLSRTSLKSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTV
                     YNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIP
                     ALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASD
                     PSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKEIDGKIYQILY
                     REGEKEAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTN
                     KTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPH
                     KGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMN
                     NRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQ
                     MSAIHTMHNGKEYIILSNAGGPNRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSL
                     QELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSKDLIFPTEAKVKRTREMGKGEMG
                     KGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKG
                     SIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLV
                     TLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ"
     gene            4798..5250
                     /locus_tag="ACL8AS_001061"
     CDS             4798..5250
                     /locus_tag="ACL8AS_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HGS1228936.1"
                     /translation="MIITKISRLGTYVGVNPHFATLIDFLEKTGLENLTEGSIAIDGN
                     RLFGNCFTYLADGQAGAFFETHQKYLDIHLVLENEEAMAVTSPENVSVTQEYDEEKDI
                     ELYTGKVEQLVHLRAGECLITFPEDLHQPKVRINDEPVKKVVFKVAIS"
     gene            5269..6606
                     /locus_tag="ACL8AS_001062"
     CDS             5269..6606
                     /locus_tag="ACL8AS_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1228937.1"
                     /translation="MKKMRKFLCLAGIALAAVALVACSGKKEATTSTEPPTELSGEIT
                     MWHSFTQGPRLESIQKSADAFMQKHPKTKIKIETFSWNDFYTKWTTGLANGNVPDIST
                     ALPNQVMEMVNSDALVPLNDSIKRIGQDKFNETALNEAKIGDDYYSVPLYSHAQVMWV
                     RTDLLKEHNIEVPKTWDQLYEASKKLKEAGVYGLSVPFGTNDLMATRFLNFYVRSGGG
                     SLLTKDLKADLTSQLAQDGIKYWVKLYKEISPQDSLNFNVLQQATLFYQGKTAFDFNS
                     GFHIGGINANSPQLIDSIDAYPIPKIKESDKDQGIETSNIPMVVWKNSKHPEVAKAFL
                     EALYNEEDYVKFLDSTPVGMLPTIKGISDSAAYKENETRKKFKHAEEVITEAVKKGTA
                     IGYENGPSVQAGMLTNQHIIEQMFQDIITNGTDPMKAAKEAEKQLNDLFEAVQ"
     gene            6685..7569
                     /locus_tag="ACL8AS_001063"
     CDS             6685..7569
                     /locus_tag="ACL8AS_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1228938.1"
                     /translation="MVKERNLTRWIFVLPAMIIVGLLFVYPFFSSIFYSFTNKHLIMP
                     NYKFVGLANYKAVLSDPNFFNAFFNSIKWTVFSLVGQVLVGFVLALALHRVRHFKKLY
                     RTLLIVPWAFPTIVIAFSWQWILNGVYGYLPNLIVKLGLMEHTPAFLTDSTWAFLCLV
                     FINIWFGAPMIMVNVLSALQTVPEEQFEAAKIDGASSWQVFKFIVFPHIKVVVGLLVV
                     LRTVWIFNNFDIIYLITGGGPANATTTLPIFAYNLGWGTKLLGRASAVTVLLFIFLVA
                     ICFIYFAIISKWEKEGRK"
     gene            7569..8402
                     /locus_tag="ACL8AS_001064"
     CDS             7569..8402
                     /locus_tag="ACL8AS_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1228939.1"
                     /translation="MKKKSSIYLDILSHVLLVGATIVAIFPLVWIIISSVKGKGELTQ
                     YPTRFWPEQFTLDYFTHVINDLHFIDNIRNSLIIALATTLIAIIISAMAAYGIVRFFP
                     KLGAIMSRLLVITYIFPPILLAIPYSIAIAKVGLTNSLFGLMMVYLSFSVPYAVWLLV
                     GFFQTVPIGIEEAARIDGANKFVTFYKVVLPIVAPGIVATAIYTFINAWNEFLYALIL
                     INNTGKMTVAVALRSLNGSEILDWGDMMAASVIVVLPSIIFFSIIQNKIASGLSEGSV
                     K"
     gene            8420..10513
                     /gene="nanB"
                     /locus_tag="ACL8AS_001065"
     CDS             8420..10513
                     /gene="nanB"
                     /locus_tag="ACL8AS_001065"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="neuraminidase NanB"
                     /protein_id="HGS1228940.1"
                     /translation="MNKRGLYSKLGISVVGISLLMGVPTLIHANELNYGQLSISPIFQ
                     GGSYQLNNKSIDISSLLLDKLSGESQTVVMKFKADEPNSLQALFGLSNSKAGFKNNYF
                     SIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGKHKGQAVENTLVFVSDSKDKTYTMY
                     VNGIEVFSETVDTFLPISNINGIDKATLGAVNREGKEHYLAKGSIDEISLFNKAISDQ
                     EVSNIPLSNPFQLIFQSGDSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKIN
                     IATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDK
                     KSGKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVRENGVVY
                     DETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLRERHNGKQVPMNVFYKDSL
                     FKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHNGTYLCPGQGLALKSSNRLIFAT
                     YTSGELTYLISDDSGQTWKKSSASIPFKNATAEAQMVELRDGVIRTFFRTTTGKIAYM
                     TSRDSGETWSEVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQL
                     VVGLVNKEDDSIDWKYHYDIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLS
                     NVVQYIDLEINDLTK"
     gene            10525..11628
                     /locus_tag="ACL8AS_001066"
     CDS             10525..11628
                     /locus_tag="ACL8AS_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HGS1228941.1"
                     /translation="MVKYGVVGAGYFGAELARYMQKNDGAEITLLYDPDNAEAIAEEL
                     GAKVASSLDELVSSDEVDCVIVATPNNLHKEPVIKAAQHGKNVFCEKPIALSYQDCRE
                     MVDVCKENNVTFMAGHIMNFFNGVHHAKELINQGVIGDVLYCHTARNGWEEQQPSVSW
                     KKIREKSGGHLYHHIHELDCVQFLMGGMPETVTMTGGNVAHEGEHFGDEDDMIFVNME
                     FSNKRFALLEWGSAYRWGEHYVLIQGSKGAIRLDLFNCKGTLKLDGQESYFLIHESQE
                     EDDDRTRIYHSTEMDGAIAYGKPGKRTPLWLSSVIDKEMRYLHEIMEGAPVSEEFAKL
                     LTGEAALEAIATADACTQSMFEDRKVKLSEIVK"
     gene            11802..12500
                     /locus_tag="ACL8AS_001067"
     CDS             11802..12500
                     /locus_tag="ACL8AS_001067"
                     /EC_number="5.1.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009385 - N-acylmannosamine-6-phosphate
                     2-epimerase activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006051 - N-acetylmannosamine metabolic
                     process [Evidence IEA];
                     GO_process: GO:0019262 - N-acetylneuraminate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HGS1228942.1"
                     /translation="MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAA
                     EQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIE
                     VIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTL
                     SGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAIT
                     RPKEITERFVASLK"
     gene            12519..14036
                     /locus_tag="ACL8AS_001068"
     CDS             12519..14036
                     /locus_tag="ACL8AS_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HGS1228943.1"
                     /translation="MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPIL
                     DNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKRDKGTAALAGVTGYLVMTATI
                     KALVKLFMAEGSAIDTGVIGALAVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTS
                     FSSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPM
                     FWYTELGGVETIAGQTVVGAQKIFFAQLADPAHSGLFTEGTRFFAGRFSTMMFGLPAA
                     CLAMYHSVPKNRRKKYAGLFFGVALTSFITGITEPIEFMFLFVSPVLYVVHAFLDGVS
                     FFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPIGLIWSVLYYIIFRWFI
                     TQFNVLTPGRGEEVDSKEISESADSTSNTADYLKQDSLQIIRALGGSNNIEDVDACVT
                     RLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQAIYGAKAILYKNSINEILGVDD"
     gene            14161..15489
                     /locus_tag="ACL8AS_001069"
     CDS             14161..15489
                     /locus_tag="ACL8AS_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1228944.1"
                     /translation="MKFRKLACTVLAGAAVLGLAACGNSGGSKDAAKSGGDGAKTEIT
                     WWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDIKVKLETIDFKSGPEKITTAIEAGT
                     APDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPISS
                     APFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGT
                     RAFISNLYSGSVTDEKVSKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNF
                     ANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSDEGKPALEYLVNGFAVFNNKD
                     DKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP
                     YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQ"
     gene            15742..16608
                     /locus_tag="ACL8AS_001070"
     CDS             15742..16608
                     /locus_tag="ACL8AS_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1228945.1"
                     /translation="MRETVISYAFLAPVLFFFVIFVLAPMVMGFITSFFNYSMTKFEF
                     VGLDNYIRMFKDPVFTKSLINTVILVIGSVPVVVLFSLFVASQTYHQNVIARSFYRFV
                     FFLPVVTGSVAVTVVWKWIYDPLSGILNFVLKSSHIISQNISWLGDKNWALMAIMIIL
                     LTTSVGQPIILYIAAMGNIDNSLVEAARVDGATEFQVFWKIKWPSLLPTTLYIAIITT
                     INSFQCFALIQLLTSGGPNYSTSTLMYYLYEKAFQLTEYGYANTIGVFLAVMIAIVSF
                     VQFKVLGNDVEY"
     gene            16624..17463
                     /locus_tag="ACL8AS_001071"
     CDS             16624..17463
                     /locus_tag="ACL8AS_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1228946.1"
                     /translation="MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPD
                     TIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAK
                     KRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM
                     KQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLV
                     MLTSRNNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGA
                     VKG"
     gene            17736..18188
                     /locus_tag="ACL8AS_001072"
     CDS             17736..18188
                     /locus_tag="ACL8AS_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HGS1228947.1"
                     /translation="MIFDDLKNITFYKGIHPNLDKAIDYLYQHRKDSFELGKYEIDGD
                     KVFLVVQENVLNQVENNQFEHHKNYADLHLLIEGHEYSSYGSRIKDEAVAFDEASDIG
                     FVHCHEHYPLLLGYHNFAIFFPGEPHQPNGYAGMEEKVRKYLFKILID"
     gene            18360..18638
                     /locus_tag="ACL8AS_001073"
     CDS             18360..18638
                     /locus_tag="ACL8AS_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001828800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228948.1"
                     /translation="MAWIIRGIVNALIGRYIKLGTYAAKYGISMARSILSRAAATAAA
                     RVGLLTKIFGWILRIAVLAADVYGNFANNIAAAWDAHDKIPNNGRINF"
     gene            18924..19568
                     /locus_tag="ACL8AS_001074"
     CDS             18924..19568
                     /locus_tag="ACL8AS_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000057467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HGS1228949.1"
                     /translation="MAQKGVSLIKAAFDTDNFLMRFSEKVLDIVTANLLFVVSCLPIV
                     TIGVAKISLYETMFEIKKSRRVPVFKIYLRSFKQNLKLGLQLGLLELGIVSLSLLDLY
                     LFWGQTALPFQLLKAICLGILIFLTIVMLASYPIAARYDLTWKEVLQKGLILASFNFP
                     WFFLMLAILVLIVMVLYLSAFSLLLGGSVFLLFGFGLLVFIQTGLMEKIFAKYQ"
     gene            19737..20654
                     /locus_tag="ACL8AS_001075"
     CDS             19737..20654
                     /locus_tag="ACL8AS_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HGS1228950.1"
                     /translation="MSDLKKYEGVIPAFYACYDDQGEVSPERTRALVQYFIDKGVQGL
                     YVNGSSGECIYQSVEDRKLILEEVMAVAKGKLTIIAHVACNNTKDSMELARHAESLGV
                     DAIATIPPIYFRLPEYSVAKYWNDISSAAPNTDYVIYNIPQLAGVALTPSLYTEMLKN
                     PRVIGVKNSSMPVQDIQTFVSLGGEDHIVFNGPDEQFLGGRLMGARAGIGGTYGAMPE
                     LFLKLNQLIADKDLETARELQYAINAIIGKLTSAHGNMYGVIKEVLKINEGLNIGSVR
                     SPLTPVTEEDRPVVEAAAALIRETKERFL"
     gene            20672..21556
                     /locus_tag="ACL8AS_001076"
     CDS             20672..21556
                     /locus_tag="ACL8AS_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HGS1228951.1"
                     /translation="MTYYVAIDIGGTNIKYGLVDQEGQLLESHEMPTEAHKGGPHILQ
                     KTKDIVASYLEKGPVAGVAISSAGMVDPDKGEIFYAGPQIPNYAGTQFKKEIEESFTI
                     PCEIENDVNCAGLAEAVSGSGKGASVTLCLTIGTGIGGCLIMDRKVFHGFSNSACEVG
                     YMHMQDGAFQDLASTTALVKYVAEAHGEDVDQWNGRRIFKEATEGNKICMEGIDRMVD
                     YLGKGLANICYVANPEVVILGGGIMGQEAILKPKIRTALKEALVPSLAEKTRLEFAHH
                     QNTAGMLGAYYHFKTKQS"
     gene            complement(21572..22423)
                     /locus_tag="ACL8AS_001077"
     CDS             complement(21572..22423)
                     /locus_tag="ACL8AS_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA];
                     GO_process: GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HGS1228952.1"
                     /translation="MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVT
                     QKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQANQVSKHSPLTKRVLRSYSNMR
                     EQTQDLIDEIQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQD
                     GFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFTSVPNKDSQTYTET
                     VLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRR
                     QKRVRKS"
     gene            22623..24680
                     /gene="pbp2b"
                     /locus_tag="ACL8AS_001078"
     CDS             22623..24680
                     /gene="pbp2b"
                     /locus_tag="ACL8AS_001078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2B"
                     /protein_id="HGS1228953.1"
                     /translation="MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNK
                     DFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETA
                     KKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNN
                     AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMP
                     GISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQ
                     YEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFN
                     SELGNGGAKYSEGVYAVALNPKTGAVLSMSGLKHDLKTGELTPDSLGTVTNVFVPGSV
                     VKAATISSGWENGVLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSN
                     AYMVQTALGIMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFV
                     PKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGD
                     LIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGAAVSISGKTGTA
                     ESYVEGGQEANNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYNQHH
                     PMN"
     gene            24691..25287
                     /gene="recR"
                     /locus_tag="ACL8AS_001079"
     CDS             24691..25287
                     /gene="recR"
                     /locus_tag="ACL8AS_001079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombination mediator RecR"
                     /protein_id="HGS1228954.1"
                     /translation="MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFA
                     KNLLSAKRELTYCSICGRLTDDDPCSICTDPTRDQTTILVLEDSRDVAAMENIQEYHG
                     LYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLL
                     KPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL"
     gene            25463..26506
                     /locus_tag="ACL8AS_001080"
     CDS             25463..26506
                     /locus_tag="ACL8AS_001080"
                     /EC_number="6.3.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HGS1228955.1"
                     /translation="MKQTIILLYGGRSAEREVSVLSAESVMRAVNYDRFTVKTFFISQ
                     SGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSV
                     QGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEV
                     EEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVG
                     LLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFR
                     AIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDL
                     AKESFDKREAHLI"
     gene            26590..27963
                     /gene="murF"
                     /locus_tag="ACL8AS_001081"
     CDS             26590..27963
                     /gene="murF"
                     /locus_tag="ACL8AS_001081"
                     /EC_number="6.3.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0047480 -
                     UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase
                     activity [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HGS1228956.1"
                     /translation="MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVP
                     LKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDV
                     FAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMG
                     QDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAP
                     ADPIVEDYLPTDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQVLDLPVTGKYNAT
                     NAMIASYVALQEGVSEEQIHQAFQDLELTRNRTEWKKAANGADILSDVYNANPTAMKL
                     ILETFSAIPANEGGKKIAVLADMKELGNQSVQLHNQMILSLSPDVLDTVIFYGEDIAE
                     LAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLSANDQILLKGSNSMNLAMLVE
                     SLENETK"
     gene            27950..28561
                     /locus_tag="ACL8AS_001082"
     CDS             27950..28561
                     /locus_tag="ACL8AS_001082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase N-terminal domain-containing
                     protein"
                     /protein_id="HGS1228957.1"
                     /translation="MKPSDFVKYLQRMIALTDTGLTFTKDPFDRERYEDLRSLLSEML
                     NQGSDLDAEEVAEVLKPTSAYATPLMDVRAWIVEDEKICLVRGQGEGSWALPGGFGEV
                     GYSPTENILKEIEEETGFKAKVERLLAVFDINRFQLQSKQYAKFVFECKLLDGQFQEN
                     QEIADLQFFAIDQLPVLSEKRITKEQIEILWQVYQGQREQYLD"
     gene            28652..29356
                     /locus_tag="ACL8AS_001083"
     CDS             28652..29356
                     /locus_tag="ACL8AS_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001055242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02206 family membrane protein"
                     /protein_id="HGS1228958.1"
                     /translation="MNLWDIFFTTQATKPPKFDLFWYVSLFTLLALTFYTAHRYREKK
                     VYQRFFQILQTVQLILLYGWYWVNHMPLSESLPFYHCRMAMFVVLLLPGQSKYKQYFA
                     LLGTFGTLAAFVYPVPDAYPFPHITILSFIFGHLALLGNSLVYLLRQYNARLLDVKGI
                     FLMTFALNALIFVVNLVTGGDYGFLTKPPLVGDHGLVANYLLVSIVLVATISLTKKIL
                     EFFLAQEAEKMIVKEA"
     gene            29575..30948
                     /gene="ftsA"
                     /locus_tag="ACL8AS_001084"
     CDS             29575..30948
                     /gene="ftsA"
                     /locus_tag="ACL8AS_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0043093 - FtsZ-dependent cytokinesis
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsA"
                     /protein_id="HGS1228959.1"
                     /translation="MAREGFFTGLDIGTSSVKVLVAEQRNGELNVIGVSNAKSKGVKD
                     GIIVDIDAAATAIKSAISQAEEKAGISIKSVNVGLPGNLLQVEPTQGMIPVTSDTKEI
                     TDQDVENVVKSALTKSMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVRLEMRGLLYT
                     GPRTILHNLRKTVERAGVQVENVIISPLAMVQSVLNEGEREFGATVIDMGAGQTTVAT
                     IRNQELQFTHILQEGGDYVTKDISKVLKTSRKLAEGLKLNYGEAYPPLASKETFQVEV
                     IGEVEAVEVTEAYLSEIISARIKHILEQIKQELDRRRLLDLPGGIVLIGGNAILPGMV
                     ELAQEVFGVRVKLYVPNQVGIRNPAFAHVISLSEFAGQLTEVNLLAQGAIKGENDLSH
                     QPISFGGMLQKTAQFVQSTPVQPAPAPEVEPVAPTEPMADFQQASQNKPKLADRFRGL
                     IGSMFDE"
     gene            30965..32224
                     /gene="ftsZ"
                     /locus_tag="ACL8AS_001085"
     CDS             30965..32224
                     /gene="ftsZ"
                     /locus_tag="ACL8AS_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000144288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HGS1228960.1"
                     /translation="MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAA
                     NTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFI
                     TAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVD
                     TLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTV
                     MANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEA
                     EEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARSATN
                     YRETVKPAHSHGFDRHFDMAETAELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSV
                     VSPVERFEAPISQDEDELDTPPFFKNR"
     gene            32229..32900
                     /locus_tag="ACL8AS_001086"
     CDS             32229..32900
                     /locus_tag="ACL8AS_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HGS1228961.1"
                     /translation="MNVKENTELVFREVAEASLSAHRESGSVSVIAVTKYVDVPTAEA
                     LLPLGVHHIGENRVDKFLEKYEALKDRDVTWHLIGTLQRRKVKDVIQYVDYFHALDSV
                     KLAGEIQKRSDRVIKCFLQVNISKEESKHGFSREELLEILPELARLDKIEYVGLMTMA
                     PFEASSEQLKEIFKAAQDLQREIQEKQIPNMPMTELSMGMSRDYKEAIQFGSTFVRIG
                     TSFFK"
     gene            32910..33449
                     /locus_tag="ACL8AS_001087"
     CDS             32910..33449
                     /locus_tag="ACL8AS_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HGS1228962.1"
                     /translation="MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTSVNSSQEPALP
                     MNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDTTEIVDLLAG
                     NESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRL
                     PDEDQQGEFGFDMKRNRVR"
     gene            33449..33712
                     /locus_tag="ACL8AS_001088"
     CDS             33449..33712
                     /locus_tag="ACL8AS_001088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HGS1228963.1"
                     /translation="MIFLIRMIYNAVDIYSLILVAFAVMSWFPGAYESSLGRWIVALV
                     KPVLAPLQRLPLQIAGLDLSVWVAIVLVRFLGENLVRFLAMIG"
     gene            33709..34494
                     /locus_tag="ACL8AS_001089"
     CDS             33709..34494
                     /locus_tag="ACL8AS_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HGS1228964.1"
                     /translation="MNKGIYQHFSIEDRPFLDKGMEWIKKVEDSYAPFLTPFINPHQE
                     KLLKILAKTYGLACSSSGEFVSSEYVRVLLYPDYFQPEFSDFEISLQEIVYSNKFEHL
                     THAKILGTVINQLGIERKLFGDILVDEERAQIMINQQFLLLFQDGLKKIGRIPVSLEE
                     RPFTEKIDKLEQYRELDLSVSSFRLDVLLSNVLKLSRNQANQLIEKKLVQVNYHVVDK
                     SDYTVQVGDLISVRKFGRLRLLQDKGQTKKEKKKITVQLLLSK"
     gene            34503..35291
                     /gene="divIVA"
                     /locus_tag="ACL8AS_001090"
     CDS             34503..35291
                     /gene="divIVA"
                     /locus_tag="ACL8AS_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIVA"
                     /protein_id="HGS1228965.1"
                     /translation="MPITSLEIKDKTFGTRFRGFDPEEVDEFLDIVVRDYEDLVRANH
                     DKNLRIKSLEERLSYFDEIKDSLSQSVLIAQDTAERVKQAAHERSNNIIHQAEQDAQR
                     LLEEAKYKANEILRQATDNAKKVAVETEELKNKSRVFHQRLKSTIESQLAIVESSDWE
                     DILRPTATYLQTSDEAFKEVVSEVLGEPIPAPIEEEPIDMTRQFSQAEMAELQARIEV
                     ADKELSEFEAQIKQEVETPTPVVSPQVEEEPLLIQLAQCMKNQK"
     gene            35639..38431
                     /gene="ileS"
                     /locus_tag="ACL8AS_001091"
     CDS             35639..38431
                     /gene="ileS"
                     /locus_tag="ACL8AS_001091"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004822 - isoleucine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HGS1228966.1"
                     /translation="MKLKDTLNLGKTEFPMRAGLPTKEPVWQKEWEDAKLYQRRQELN
                     QGKPHFTLHDGPPYANGNIHVGHAMNKISKDIIVRSKSMSGFYAPFIPGWDTHGLPIE
                     QVLSKQGVKRKEMDLVEYLKLCREYALSQVDKQREDFKRLGVSGDWENPYVTLTPDYE
                     AAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGK
                     GVLDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPVGEARKFVVAAELLTSLSEK
                     FGWADVQVLETYRGQELNHIVTEHPWDTAVEELVILGDHVTTDSGTGIVHTAPGFGED
                     DYNVGIANNLEVAVTVDERGIMMKNAGPEFEGQFYEKVVPTVIEKLGNLLLAQEEISH
                     SYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDEIEKVKFHSEWGKVRLYNMIRDRGD
                     WVISRQRTWGVPLPIFYAEDGTAIMVAETIEHVAQLFEKHGSSIWWERDAKDLLPEGF
                     THPGSPNGEFKKETDIMDVWFDSGSSWNGVVVNRPELTYPADLYLEGSDQYRGWFNSS
                     LITSVANHGVAPYKQILSQGFALDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTS
                     VDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDTVAYDELRSVDKYMT
                     IRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQ
                     MQTVFYDILVKITKLLTPILPHTAEEIWSYLEFEAEDFVQLSELPEAQTSANQEEILD
                     TWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIV
                     SELTIAEEPTPEAALSFEDVAFTVERAAGEVCDRCRRIDPTTAERSYQAVICDHCASI
                     VEENFADAVAEGFEEK"
BASE COUNT        12074 a         6766 c         8394 g        11472 t
ORIGIN      
        1 gtcagtctta tctacaacct caaaacagtg ttttgagcat catgcggcta gcttcttagt
       61 ttgctctttg attttcattg agtataaaaa cagatgagtt tctgttttct ttttatggac
      121 tataaatgtt cagctgaaac tactttcaag gacattatta tataaaagaa ttttttgaaa
      181 ctaaaatcta ctatattaca ctatattgaa agcgttttaa aaatgaggta taataaattt
      241 attaacactt ataaaaagtg atagaatcta tctttatgta tatttaaaga tagattgctg
      301 taaaaatagt agtagctatg cgaaataaca gatagagaga agggattgaa gcttagaaaa
      361 ggggaataat atgatattta aggcattcaa gacaaaaaag cagagaaaaa gacaagttga
      421 actacttttg acagtttttt tcgacagttt tctgattgat ttatttcttc acttatttgg
      481 gattgtcccc tttaagctgg ataagattct gattgtgagc ttgattatat ttcccattat
      541 ttctacaagt atttatgctt atgaaaagct atttgaaaaa gtgttcgata aggattgagc
      601 aggaagtatg gtgtaaatag cataagctga tgtccatcat ttgcttataa agagatattt
      661 tagtttaatt gcagcggtgt cctggtagat aaactagatt ggcaggagtc tgattggaga
      721 aaggagaggg gaaatttggc accaatttga gatagtttgt ttagttcatt tttgtcattt
      781 aaatgaactg tagtaaaaga aagttaataa aagacaaact aagtgcattt tctggaataa
      841 atgtcttatt tcagaaatcg ggatatagat atagagagga tcagtatgaa tcggagtgtt
      901 caagaacgta agtgtcgtta tagcattagg aaactatcgg taggagcggt ttctatgatt
      961 gtaggagcag tggtatttgg aacgtctcct gttttagctc aagaaggggc aagtgagcaa
     1021 cctctggcaa atgaaactca actttcgggg gagagctcaa ccctaactga tacagaaaag
     1081 agccagcctt cttcagagac tgaactttct ggcaataagc aagaacaaga aaggaaagat
     1141 aagcaagaag aaaaaattcc aagagattac tatgcacgag atttggaaaa tgtcgaaaca
     1201 gtgatagaaa aagaagatgt tgaaaccaat gcttcaaatg atcagagagt tgatttatca
     1261 agtgaactag ataaactaaa gaaacttgaa aacgcaacag ttcacatgga gtttaagcca
     1321 gatgccaagg ccccagcatt ctataatctc ttttctgtgt caagtgctac taaaaaagat
     1381 gagtacttca ctatggcagt ttacaataat actgctactc tagaggggcg tggttcggat
     1441 gggaaacagt tttacaataa ttacaacgat gcacccttaa aagttaaacc aggtcagtgg
     1501 aattctgtga ctttcacagt tgaaaaaccg acagcagaat tgccaaatgg tcgagttcgc
     1561 ctctacgtaa acggggtatt atctcgaaca agtctgaaat ctggcaattt cattaaagat
     1621 atgccagatg taacgcatgt gcaaatcgga gcaaccaagc gtgccaacaa tacggtttgg
     1681 gggtcaaatc tacagattcg gaatctcact gtgtataatc gtgctttaac accagaagag
     1741 gtacaaaaac gtagtcaact ttttaaacgc tcagatttag aaaaaaaact acctgaagga
     1801 gcggctttaa cagagaaaac ggacatattc gaaagcgggc gtaacggtaa accaaataaa
     1861 gatggaatca agagttatcg tattccagca cttctcaaga cagataaagg aactttgatc
     1921 gcaggtgcag atgaacgccg tctccattcg agtgactggg gtgatatcgg tatggtcatc
     1981 agacgtagtg aagataatgg taaaacttgg ggtgaccgag taaccattac caacttacgt
     2041 gacaatccaa aagcttctga cccatcgatc ggttcaccag tgaatatcga tatggtgttg
     2101 gttcaagatc ctgaaaccaa acgaatcttt tctatctatg acatgttccc agaagggaag
     2161 ggaatctttg gaatgtcttc acaaaaagaa gaagcctaca aagaaatcga tggaaaaatc
     2221 tatcaaatcc tctatcgtga gggagaaaag gaagcttata ccattcgaga aaatggtact
     2281 gtctatacac cagatggtaa ggcgacagac tatcgcgttg ttgtagatcc tgttaaacca
     2341 gcctatagcg acaagggtga tctatacaag ggtaaccaat tactaggcaa tatctacttc
     2401 acaacaaaca aaacttctcc atttagaatt gccaaggata gctatctatg gatgtcctac
     2461 agtgatgacg acgggaagac atggtcagcg cctcaagata ttactccgat ggtcaaagcc
     2521 gattggatga aattcttggg tgtaggtcct ggaacaggaa ttgtacttcg gaatgggcct
     2581 cacaagggac ggattttgat accggtttat acgactaata atgtatctca cttaaatggc
     2641 tcgcaatctt ctcgtgtcat ctattcagat gatcatggaa aaacttggca tgctggagaa
     2701 gcggtcaacg ataaccgtca ggtagacggt caaaagatcc actcttctac gatgaacaat
     2761 agacgtgcgc aaaatacaga atcaacggtg gtacaactaa acaatggaga tgttaaactc
     2821 tttatgcgtg gtttgactgg agatcttcag gttgctacaa gtaaagacgg aggagtgact
     2881 tgggagaagg atatcaaacg ttatccacag gttaaagatg tctatgttca aatgtctgct
     2941 atccatacga tgcataatgg aaaagaatac attatcctca gcaatgcagg tggaccgaat
     3001 cgtgaaaatg ggatggtcca cttggcacgt gtcgaagaaa atggtgagtt gacttggctc
     3061 aaacacaatc caattcaaaa aggagagttt gcctataatt cgctccaaga attaggaaat
     3121 ggggagtatg gcatcttgta tgaacatact gaaaaaggac aaaatgccta taccctatca
     3181 tttagaaaat ttaattggga atttttgagc aaagatctga tttttcctac cgaagcgaaa
     3241 gtgaagcgaa ctagagagat gggcaaagga gagatgggca aaggagttat tggcttggag
     3301 ttcgactcag aagtattggt caacaaggct ccaacccttc aattggcaaa tggtaaaaca
     3361 gcgactttcc taacccagta tgatagcaag accttgttgt ttgcagtaga taaggaagat
     3421 atcggacagg aaattattgg tatagctaaa ggaagcatcg aaagtatgca taatcttcct
     3481 gtaaatctag caggtgccag agttcctggc ggagtaaatg gtagcaaagc agcggtgcat
     3541 gaagttccag aatttacagg gggagttaat ggtacagagc cagctgttca tgaaatcgca
     3601 gagtataagg gatctgattc gcttgtaact cttactacaa aagaagatta tacttacaaa
     3661 gctcctcttg ctcagcaggc acttcctgaa acaggaaaca aggagagtga cctcctagct
     3721 tcactaggac taacagcttt cttccttggt ctgtttacgc tagggaaaaa gagagaacaa
     3781 taagagaaga attctaaaca tttgattttg taaaaataga aggagatagc aggttttcaa
     3841 gcctgctatc tttttttgat gacattcagg ctgatacgaa atcataagag gtctgaaact
     3901 actttcagag tagtctgttc tataaaatat agtagattga aataagatgt gaacaactct
     3961 atcaggaaag tcaaattaat ttatagaaaa attttagcag tcaaggtgta ctgttataga
     4021 ttcaatatat tatgcgacta ttaaccttgt cttctcctaa aattgacttt cttgttttct
     4081 tatcttgtcc actcgaaaca agtattgtaa gaatttgatt atttttgaaa gtacttttaa
     4141 tatacttgat atagttaaaa aagatttgaa actaaattcc aaattagaaa aagacttgaa
     4201 atactaaaaa aaaaaagtat actctaattg aaaacggtaa caaaactaat ttagagaatg
     4261 aaatatagag tatttctctc ttaaaagttt ttggtgaaac gagatgtaga aaggagattt
     4321 agccaaagag tctattagtg ctagaataat agattagaat tattttagaa aaacgaagtg
     4381 agcagcttat aaattcaagt ccccaaatag attcatacta gtatcttttg caaaaaataa
     4441 agggcgactt ccttcatgaa tatcaatttc atctataagg aaggtagcta attgaactaa
     4501 cttatttatt ctgtttgtcg ctagaaaaat cagacctcct tgtgaagatt gaggagatac
     4561 tgaatgaaaa tcaaagaaga aactagcaag ctagtagcag attgcccaaa acaccgcttt
     4621 gaggttgtag ataagactga cctatataat ccaaggtgaa gcgactgtgg tttgaagaga
     4681 ttttcaaaga gtataggcta gagagtagtg tttttatgtc cttctagtag aaaatgctag
     4741 acagaagaat ggggaacttg gataggaaaa atagattgag aaaggaggtt agaagagatg
     4801 attattacaa aaattagccg tttaggaact tatgtgggag taaatccaca ttttgcaaca
     4861 ttaatagatt ttctagaaaa aacaggacta gaaaatttaa cagaaggttc gattgctatc
     4921 gatggtaatc gattgtttgg gaattgcttt acttatctag cagatggtca agcaggggct
     4981 ttctttgaaa cacaccaaaa atatttggat attcatttag ttttggaaaa cgaagaagcc
     5041 atggctgtta catcgccgga aaatgtaagc gttacccaag aatatgatga agagaaagat
     5101 attgaattat acacagggaa agtggaacag ttggttcatt tgagagctgg cgaatgcctc
     5161 atcacttttc cagaagattt acatcaaccc aaggttcgta taaatgatga acctgtgaaa
     5221 aaagttgtct ttaaagttgc gatttcttaa tgtagaaaga gaagaacgat gaaaaaaatg
     5281 agaaagtttt tatgtctagc tggaattgcg ctagcggctg ttgccttggt agcttgttca
     5341 ggaaaaaaag aagctacaac tagtactgaa ccaccaacag aattatctgg tgagattaca
     5401 atgtggcact cctttactca aggaccccgt ttagaaagta ttcaaaaatc agcagatgct
     5461 ttcatgcaaa agcatccaaa aacgaaaatc aagattgaaa cattttcttg gaatgacttc
     5521 tatactaaat ggactacagg tttagcaaat ggaaatgtgc cagatatcag tacagctctt
     5581 cctaaccaag taatggaaat ggtcaactca gatgctttgg ttccgctaaa tgattctatc
     5641 aagcgtattg gacaagataa atttaacgaa actgccttaa atgaagcaaa aatcggagat
     5701 gattactact ctgttcctct ttattcacat gcacaagtca tgtgggttag aacagatttg
     5761 ttaaaagaac ataatattga ggttcctaaa acttgggatc aactctatga agcttctaaa
     5821 aaattgaaag aagctggagt ttatggcttg tctgttccgt ttggaacaaa tgacttaatg
     5881 gcaacacgtt tcttgaactt ctacgtacgt agtggtggag gaagcctctt aacaaaagat
     5941 cttaaagcag acttgacaag ccaacttgct caagatggta ttaaatactg ggttaaattg
     6001 tataaagaaa tctcacctca agactctttg aactttaatg tccttcaaca agctaccttg
     6061 ttctatcaag gaaaaacagc atttgacttt aactctggct tccatatcgg aggaattaat
     6121 gccaacagtc ctcaattgat tgattcgatt gatgcttatc ctattccaaa aatcaaagag
     6181 tctgataaag accaaggaat tgaaacctca aacattccaa tggttgtttg gaaaaattca
     6241 aaacatccag aagttgctaa agcattctta gaagcacttt ataatgaaga agactacgtt
     6301 aaattccttg attcaactcc agtaggtatg ttgccaacta ttaaggggat tagcgattct
     6361 gcagcctata aagaaaatga aactcgtaag aagtttaaac atgctgaaga agtaattact
     6421 gaagctgtta aaaaaggtac tgctattggt tatgaaaatg gaccaagtgt acaagctggt
     6481 atgttgacta accaacacat tattgaacaa atgttccaag atatcattac aaatggaaca
     6541 gatcctatga aagcagcaaa agaagcagaa aaacaattaa acgatttatt tgaggctgtt
     6601 cagtagatgt aaaagactag aaaataggtg ggctagtgag ctgaaaagct ctagcccaat
     6661 cttgtaaaag aagggagaag gagaatggtt aaagaacgta atttaactcg ctggatattt
     6721 gttttgccag ctatgattat cgtaggatta ctctttgttt atccgttttt ctcgagtatt
     6781 ttttatagct ttaccaataa gcatttgatt atgcctaatt ataaatttgt tggtttggct
     6841 aactataaag ctgtgctatc agatcccaac ttctttaatg cgttctttaa ttcaattaag
     6901 tggaccgttt tctcattagt tggtcaagtt ttagtagggt ttgtattggc tttagctctt
     6961 cacagagtac gccacttcaa gaaattatat aggaccttat tgattgttcc ttgggcattt
     7021 cctacaatcg ttattgcctt ctcttggcag tggattctaa acggggttta tggctactta
     7081 cctaatctaa tcgtaaaatt aggtttaatg gaacatacac ctgcattttt gacagatagt
     7141 acatgggcat tcctatgttt ggtgtttatc aacatttggt ttggagcacc aatgattatg
     7201 gttaatgtgc tttcagcttt gcaaacagta ccagaagaac aatttgaggc tgctaagata
     7261 gatggtgctt caagttggca ggtgttcaag tttatcgtct ttccacatat taaagtggtt
     7321 gtaggacttc tagttgtttt gagaactgta tggatcttta ataactttga cattatctac
     7381 ctcattactg gtggtggacc agccaatgct acaacgacgc ttccaatttt tgcttacaac
     7441 ctgggctggg gaactaaatt gttgggtcgt gcttcagcag ttacagtatt gctctttatc
     7501 ttcttggtgg cgatttgctt tatctacttt gctatcatca gtaagtggga aaaggagggt
     7561 agaaaataat gaagaagaaa tccagtattt atttagatat tctctcacat gtacttttag
     7621 ttggtgcgac catcgttgca attttcccat tggtatggat tatcatatct tctgtcaaag
     7681 ggaaagggga attaactcag tatccaacac gattttggcc tgaacagttt acattagatt
     7741 atttcactca tgttatcaac gatttgcact tcattgataa cattcgaaac agtttaatca
     7801 ttgccttggc tacaaccctt attgcgatta ttatttctgc tatggcagcc tatggtattg
     7861 ttcgattctt tcctaaattg ggagcaatca tgtcgagact actcgtcatt acctacattt
     7921 tcccaccaat tttgttagca attccctatt caattgccat tgctaaagtt gggttaacaa
     7981 atagtttatt tggcttgatg atggtttatc tatcttttag tgttccatat gcagtttggc
     8041 tcttagttgg atttttccaa acagttccaa ttggaattga agaagcggct agaattgatg
     8101 gtgcaaataa atttgttacg ttttataaag ttgtgctacc gattgtagca ccaggtattg
     8161 tagcaacagc tatttataca tttatcaatg cttggaatga attcctgtat gccttgattt
     8221 tgattaacaa tacaggaaag atgacagtag cagtagccct tcgttcactt aatggttcag
     8281 aaatactaga ctggggagat atgatggcag cgtctgttat tgtagttctt ccatcaatta
     8341 ttttcttctc tatcatccaa aataagattg caagtggatt atcagaagga tctgtgaagt
     8401 agacgaaaga aggaaaaaaa tgaataaaag aggtctttat tcaaaactag gaatttctgt
     8461 tgtaggcatt agtcttttaa tgggagttcc cactttgatt catgcgaatg aattaaacta
     8521 tggtcaactg tccatatctc ctatttttca aggaggttca tatcaactga acaataagag
     8581 tatagatatc agctctttgt tattagataa attgtctgga gagagtcaga cagtagtaat
     8641 gaaatttaaa gcagatgaac caaactctct tcaagctttg tttggcctat ctaatagtaa
     8701 agcaggcttt aaaaataatt acttttcaat tttcatgaga gattctggtg agataggtgt
     8761 agaaataaga gacgcccaaa agggaataaa ttatttattt tctagaccag cttcattatg
     8821 gggaaagcat aaaggacagg cagttgaaaa tacactagta tttgtatctg attctaaaga
     8881 taaaacatac acaatgtatg ttaatggaat agaagtgttc tctgaaacag ttgatacatt
     8941 tttgccaatt tcaaatataa atggtataga taaggcaaca ctaggagctg ttaatcgtga
     9001 aggtaaggaa cattacctcg caaaaggaag tattgatgaa atcagtctat ttaacaaagc
     9061 aattagtgat caggaagttt caaatattcc cttgtcaaat ccatttcagt taattttcca
     9121 atcaggagat tctactcaag ctaactattt tagaataccg acactatata cattaagtag
     9181 tggaagagtt ctatcaagta ttgatgcacg ttatggtggg actcatgatt ctaaaagtaa
     9241 gattaatatt gccacttctt atagtgatga taatgggaaa acgtggagtg agccaatttt
     9301 tgctatgaag tttaatgact atgaggagca gttagtttac tggccacgag ataataaatt
     9361 aaagaatagt caaattagtg gaagtgcttc attcatagat tcatccattg ttgaagataa
     9421 aaaatctggg aaaacgatat tactagctga tgttatgcct gcgggtattg gaaataataa
     9481 tgcaaataaa gccgactcag gttttaaaga aataaatggt cattattatt taaaactaaa
     9541 gaagaatgga gataacgatt tccgttatac agttagagaa aatggtgtcg tttatgatga
     9601 aacaactaat aaacctacaa attatactat aaatgataag tatgaagttt tggagggagg
     9661 aaagtcttta acagtcgaac aatattcggt tgattttgat agtggctctt taagagaaag
     9721 gcataatgga aaacaggttc ctatgaatgt tttctacaaa gattcgttat ttaaagtgac
     9781 tcctactaat tatatagcaa tgacaactag tcagaataga ggagagagtt gggaacaatt
     9841 taagttgttg cctccgttct taggagaaaa acataatgga acttacttgt gtcctggaca
     9901 aggtttagca ttaaaatcaa gtaacagatt gatttttgca acatatacta gtggagaact
     9961 aacctatctc atttctgatg atagtggtca aacatggaag aaatcctcag cttcaattcc
    10021 gtttaaaaat gcaacagcag aagcacaaat ggttgaactg agagatggtg tgattagaac
    10081 attctttaga accactacag gtaagatagc ttatatgact agtagagatt ctggagaaac
    10141 atggtcggaa gtttcgtata ttgatggaat ccaacaaact tcatatggca cacaagtatc
    10201 tgcaattaaa tactctcaat taattgatgg aaaagaagca gtcattttga gtacaccaaa
    10261 ttctagaagt ggccgtaagg gaggtcaatt agttgtcggt ttagtcaata aagaagatga
    10321 tagtattgat tggaaatacc actatgatat tgatttgcct tcgtatggtt atgcctattc
    10381 tgcgattaca gaattgccaa atcatcacat aggtgtactg tttgaaaaat atgattcgtg
    10441 gtcgagaaat gaattgcatt taagcaatgt agttcagtat atagatttgg aaattaatga
    10501 tttaacaaaa taaaggagaa aaacatggtt aaatacggtg ttgttggagc agggtatttt
    10561 ggagctgaat tggctcgcta catgcaaaaa aatgatggag cagagattac tcttctctat
    10621 gatccagata atgcagaggc gattgcagaa gaattgggag caaaagtagc aagttcctta
    10681 gatgagttgg tttctagcga tgaagtagac tgtgttatcg tcgcaactcc aaataatctt
    10741 cataaggaac cggttattaa ggctgcacag catggtaaaa atgttttctg tgaaaaacca
    10801 attgcgcttt cttatcaaga ttgtcgcgag atggtagatg tgtgtaaaga aaacaatgta
    10861 acctttatgg caggacatat tatgaatttc tttaatggtg ttcatcatgc aaaagaactc
    10921 attaatcaag gagttatcgg agacgttcta tattgtcata cagctcgtaa tggttgggaa
    10981 gaacaacaac cgtcagtatc atggaaaaaa attcgtgaaa aatcaggtgg tcacttgtat
    11041 caccacatcc atgaattgga ttgcgttcaa ttccttatgg ggggcatgcc tgaaactgta
    11101 accatgacag gtggaaatgt ggcccatgaa ggtgaacatt tcggtgatga agatgatatg
    11161 atttttgtca atatggaatt ttctaataag cgttttgcct tgttagaatg gggttcagct
    11221 tatcgttggg gtgaacatta tgtcttaatc caaggaagca aaggtgccat ccgcttagac
    11281 ttattcaact gtaaaggaac tcttaagcta gatgggcaag aaagctattt cttgattcac
    11341 gaatcgcaag aagaagatga tgatcggact cgtatctatc atagtacaga gatggatgga
    11401 gcaattgctt atggtaaacc aggtaaacgt actccattat ggctatcatc tgtcattgat
    11461 aaagaaatgc gctatctgca tgagattatg gaaggagctc cagtatcaga agaatttgca
    11521 aaacttttga caggtgaagc tgccctagaa gcaattgcta ctgcagatgc ttgtacccag
    11581 tctatgtttg aagatcgcaa agtaaaattg tcagaaattg taaaataaat tttggtattc
    11641 tcctatttat aggtcgactt gctcctctga aagtactttt agaggagctg tttgactttg
    11701 ctagtttttg aaactgaaat ctattatact acaaactatt gaaagcgttt taattttaag
    11761 gtataataat ctcatagaaa taaagaaaag gaggaaagag gatgccacag attagcaaag
    11821 aagccttgat tgagcaaatc aaagatggaa tcatcgtttc ttgtcaggct cttcctcatg
    11881 aaccgcttta tacagaagcg ggaggggtga ttcccttgct ggtcaaagcg gctgagcaag
    11941 gtggagcagt cggtatccga gcaaacagtg ttcgcgatat caaggaaatt aaggaagtca
    12001 ctaaacttcc aatcattggg attatcaaac gtgattatcc acctcaggaa cccttcatca
    12061 cggctactat gaaagaagtt gatgaattgg cagaactgga catcgaggtg attgctctgg
    12121 attgtaccaa gcgtgaacgc tacgatggtt tggaaattca agagttcatt cgtcaggtta
    12181 aggagaaata tcctaatcag cttttgatgg ctgatactag tatcttcgaa gaagggctag
    12241 cagctgtaga agcaggaatt gactttgtcg gaacaacctt atcaggctac acatcctaca
    12301 gtccaaaagt agacggtcca gattttgaat tgattaagaa actctgtgat gctggtgtag
    12361 atgtcattgc agaaggaaaa attcatacac cagaacaagc caaacaaatc cttgaatatg
    12421 gagtgcgagg catcgttgtt ggtggcgcca ttactagacc aaaagagatt acagaacgct
    12481 tcgttgctag tcttaaataa gatgtgaggg ggagttttat gtttaaagtt ttacaaaaag
    12541 ttggaaaagc ttttatgtta cctatagcta tacttcctgc agcaggtcta cttttgggga
    12601 ttggtggtgc actttcaaac ccaaccacga tagcaactta tccaatacta gacaatagta
    12661 tttttcaatc gatattccaa gtaatgagct ctgcaggaga ggttgtattc agtaatttgt
    12721 cactacttct ctgtgtggga ttatgtattg gcttagcgaa acgagataaa ggaaccgctg
    12781 cgttagcagg agtaactggt tacttagtta tgactgcaac gatcaaagct ttggtaaaac
    12841 tttttatggc agaaggatct gcaattgata ctggagttat tggagcatta gctgtcggaa
    12901 tagttgccgt atatttgcac aaccgatata acaatattca attaccttcc gctttaggat
    12961 tctttggagg ttcacgcttc gttcctattg ttacatcgtt ctcttctatc ttgattggct
    13021 ttgtcttctt tgttatttgg ccacctttcc aacaacttct tgtttctaca ggtggatata
    13081 tttctcaggc gggtccaatt ggaacttttc tatatggatt tttaatgaga ctttctggag
    13141 cagtaggctt acatcatata atttacccta tgttttggta tactgaactt ggtggtgttg
    13201 aaactattgc aggacaaaca gtggttggag ctcaaaaaat attttttgct caattagccg
    13261 atccggccca ttctggatta tttacagaag gaacaaggtt ttttgcaggt cgtttctcaa
    13321 caatgatgtt cggtttaccg gctgcctgtt tagcgatgta ccatagtgtt cctaaaaatc
    13381 gtcgtaaaaa atacgcgggt ttgttttttg gagttgcttt aacatctttt attaccggta
    13441 ttacagaacc aattgaattt atgtttctat tcgtcagtcc ggttctatat gttgttcacg
    13501 cattccttga tggtgttagc ttctttattg cagacgtctt aaatatttca ataggaaaca
    13561 cattttcagg aggtgtaatc gatttcactt tatttggaat tttgcagggg aacgctaaga
    13621 cgaattgggt tcttcagatt ccaattggac ttatttggag tgttttgtat tatattattt
    13681 ttagatggtt cattactcaa ttcaacgttc taacaccagg acgaggagaa gaagtagatt
    13741 ctaaagaaat ttctgaatcc gcagattcaa cttcaaatac tgcagattat ttaaaacagg
    13801 atagcctaca aattatcaga gcgttgggtg gatcaaataa tatagaagat gtagatgctt
    13861 gtgtgacacg tttacgtgta gctgtaaaag aagttaatca agttgataaa gcacttttaa
    13921 aacaaattgg tgcagttgat gtcttagaag tgaagggtgg cattcaagca atctatggag
    13981 caaaagcaat cttatataaa aatagtatta atgaaatttt aggtgtagat gattaagtac
    14041 ttactgactt aataaaaaac agaggagagt gatggatgag taggatgaaa tgaaatcgca
    14101 tacaagaaat aaagaactca ttatccaagt tggatacgct tattacatag gagaatacaa
    14161 atgaaattta gaaaattagc ttgtacagta cttgcgggtg ctgcggttct tggtcttgct
    14221 gcttgtggca attctggcgg aagtaaagat gctgccaaat caggtggtga cggtgccaaa
    14281 acagaaatca cttggtgggc attcccagta tttacccaag aaaaaactgg tgacggtgtt
    14341 ggaacttatg aaaaatcaat catcgaagcg tttgaaaaag caaacccaga tataaaagtg
    14401 aaattggaaa ccatcgactt caagtcaggt cctgaaaaaa tcacaacagc catcgaagca
    14461 ggaacagctc cagacgtact ctttgatgca ccaggacgta tcatccaata cggtaaaaac
    14521 ggtaaattgg ctgagttgaa cgacctcttc acagatgaat ttgttaaaga tgtcaacaat
    14581 gaaaacatcg tacaagcaag taaagctgga gacaaggctt atatgtatcc gattagttct
    14641 gccccattct acatggcaat gaacaagaaa atgttagaag atgctggagt agcaaacctt
    14701 gtaaaagaag gttggacaac tgatgatttt gaaaaagtat tgaaagcact taaagacaag
    14761 ggttacacac caggttcatt gttcagttct ggtcaagggg gagaccaagg aacacgtgcc
    14821 tttatctcta acctttatag cggttctgta acagatgaaa aagttagcaa atatacaact
    14881 gatgatccta aattcgtcaa aggtcttgaa aaagcaacta gctggattaa agacaatttg
    14941 atcaataatg gttcacaatt tgacggtggg gcagatatcc aaaactttgc caacggtcaa
    15001 acatcttaca caatcctttg ggcaccagct caaaatggta tccaagctaa acttttagaa
    15061 gcaagtaagg tagaagtggt agaagtacca ttcccatcag acgaaggtaa gccagctctt
    15121 gaatatcttg taaacgggtt tgcagtattc aacaataaag acgacaagaa agtcgctgca
    15181 tctaagaaat tcatccagtt tatcgcagat gacaaggagt ggggacctaa agacgtagtt
    15241 cgtacaggtg ctttcccagt ccgtacttca tttggaaaac tttatgaaga caaacgcatg
    15301 gaaacaatca gtggctggac tcaatactac tcaccatact acaacactat tgatggattt
    15361 gctgaaatga gaacgctttg gttcccaatg ttgcaatctg tatcaaatgg tgacgaaaaa
    15421 ccagcggatg ctttgaaagc cttcactgaa aaagcaaacg aaacaatcaa aaaagctatg
    15481 aaacaatagt ccttagttat tctatgaaaa agtaattttt taaagaacct aagagtgtat
    15541 accccctttt ccctctacac agatagtgta agaaaagggg gcttttgttt aaaatgtaag
    15601 aaactgtcac gaaattaaaa tgaagttctt acataagcga atcataaaaa atttcatttt
    15661 gattttaaaa cagttcaaga aagtcaaaaa attattctat ttgaaagaga ggtgccgact
    15721 gtgaaagtca ataaaatccg tatgcgggaa acagtgattt cctacgcttt cctagcacca
    15781 gtattattct tctttgtcat ctttgtgttg gctccgatgg tgatgggctt cattacaagt
    15841 ttctttaact actcaatgac taaatttgag tttgtaggct tggataacta tatccgtatg
    15901 tttaaagatc ctgtctttac aaaatctctg attaacacag ttattttggt tattggatct
    15961 gtaccagttg ttgttctatt ctcactcttt gtagcatctc agacctatca tcaaaatgtc
    16021 attgccagat ccttctaccg tttcgtcttc ttccttcctg ttgtaacggg tagtgttgcc
    16081 gtgacagttg tttggaaatg gatttatgac ccactatcag ggattctaaa ctttgtcctt
    16141 aagtcaagcc acatcatcag ccaaaacatt tcttggttgg gagataaaaa ctgggcattg
    16201 atggcgatta tgattattct cttgaccact tcagttggtc agcccatcat cctttatatc
    16261 gctgccatgg ggaatattga caattcactg gttgaagcgg cgcgtgttga tggtgcaact
    16321 gagtttcaag ttttctggaa gattaaatgg ccaagccttc ttccaacaac tctttatatt
    16381 gcaatcatca caacaattaa ctcattccag tgtttcgcct tgattcagct tttgacatct
    16441 ggtggtccaa actactcaac aagtaccttg atgtactacc tttacgaaaa agccttccaa
    16501 ttgacagaat acggctatgc caacacaatt ggtgtcttct tggcagtcat gattgctatc
    16561 gtaagctttg ttcaatttaa agtacttgga aacgacgtag aatactaaag aaaggagaca
    16621 gctatgcaat ctacagaaaa aaaaccatta acagccttta ctgttatttc aacaatcatt
    16681 ttgctcttgt tgactgtgct gttcatcttt ccattctact ggattttgac aggggcattc
    16741 aaatcacaac ctgatacaat tgttattcct cctcagtggt tccctaaaat gccaaccatg
    16801 gaaaacttcc aacaactcat ggtgcagaac cctgccttgc aatggatgtg gaactcagta
    16861 tttatctcat tggtaaccat gttcttagtt tgtgcaacct catctctagc aggttatgta
    16921 ttggctaaaa aacgtttcta tggtcaacgc attctatttg ctatctttat cgctgctatg
    16981 gcgcttccaa aacaagttgt ccttgtacca ttggtacgta tcgtcaactt catgggaatc
    17041 cacgatactc tctgggcagt tatcttgcct ttgattggat ggccattcgg tgtcttcctc
    17101 atgaaacaat ttagtgaaaa tattcctaca gagttgcttg aatcagctaa aatcgacggt
    17161 tgtggtgaga ttcgtacctt ctggagtgta gccttcccga ttgtgaaacc agggtttgca
    17221 gcccttgcaa tctttacctt catcaatact tggaatgact acttcatgca attggtaatg
    17281 ttgacttcac gtaacaattt gaccatctca cttggggttg cgaccatgca ggctgaaatg
    17341 gcaaccaact atggtttgat tatggcagga gctgcccttg ctgctgttcc aatcgtcaca
    17401 gtcttcctag tcttccaaaa atccttcaca cagggtatta ctatgggagc ggtcaaagga
    17461 taatactctg cgaaaatcga atgcaaacta cgtcagcttc accttgccat acttaagtat
    17521 tgcctgcggt tagcttccta gtttgttctt caattttcat tgagtatagg aaaatcaatc
    17581 tatcaagata cagaagtata ttttatagat ttagagaata tagaggttat aagtgtctac
    17641 aaaatggagg gtatgcagtt actttatgaa gttttgtcag acacttatca acttaagaat
    17701 ggttttagtt aactatcaga aacgaaggaa agagtatgat ttttgacgat ttgaaaaaca
    17761 tcacctttta caaagggatt catcccaatt tagacaaggc tatcgactac ctctaccaac
    17821 accgtaaaga ttcattcgaa ttaggaaagt atgagattga tggagataaa gtctttctag
    17881 ttgttcagga aaatgtcctc aatcaagttg agaataatca atttgaacac cataagaact
    17941 atgcagattt gcatttgctg atagaagggc atgaatattc gagctacggt tcacgtatca
    18001 aagacgaggc agtagcattc gacgaagcga gtgacattgg ctttgttcat tgtcatgaac
    18061 actacccgct cttgttgggt tatcacaatt ttgcgatttt cttcccaggt gagccacatc
    18121 agccaaatgg ttatgcaggc atggaagaaa aggttcgaaa atatctcttt aaaatcttga
    18181 ttgattaaaa ataggatgaa ttgttttttt gtaaagcttt gataatactc taccatgaaa
    18241 ttgatctttg tgaggtagag aaatgagaat aaaatattta aaaattggta tcttcttgtc
    18301 agtctgtgta tgctacaaga gctagtttct tggatggaca gggaattaca gttgatgaga
    18361 tggcttggat aattaggggc attgtgaatg cattgattgg tagatacata aaattaggta
    18421 cttatgcagc taagtatggt attagtatgg cgcgttcgat cttaagtagg gcagctgcaa
    18481 ctgcggcagc aagagtagga ttattgacta agatttttgg atggatttta cgaatagctg
    18541 tgctcgcagc tgatgtatat ggtaattttg ccaacaatat tgctgcagct tgggatgcac
    18601 atgataaaat ccctaacaat ggtcgtataa acttttaaaa tgcgagaatg aaagcacttt
    18661 gtatttttta ttgtatatgt tagcttggac agtgcttgca atgataatcc gtggagggct
    18721 agatggattt gatgaacaca cttggcgtaa tattttagct agtgcgttgt cctcgctata
    18781 catacattat atatccatag atagaaaaag aaaaaagtcc aaaagaaaaa agaaaaaata
    18841 gatttgttca tggtagggac ttatgaaagc tttactaaca aaaaagaaaa cagtttacaa
    18901 agaaaaatga tggaggagta aacatggcac aaaaaggagt aagccttatc aaggcagcat
    18961 ttgatacaga taactttctt atgcgtttta gtgagaaagt cttggacatc gtgacagcca
    19021 atcttctttt tgtcgtctct tgtttgccca tcgtgacgat tggagtggct aaaatcagcc
    19081 tctacgagac catgtttgag attaagaaga gcagacgggt gcctgttttt aaaatctatc
    19141 taagatcttt caagcaaaat ctgaaactag gtcttcagtt aggtctgctt gagttgggca
    19201 ttgtttcatt aagcctccta gatctttatc tcttttgggg tcaaacagct ctgccctttc
    19261 aattgctgaa agctatttgt ctaggcattc tgattttcct tacgattgtg atgttggcta
    19321 gctatccaat cgcggcacgt tatgatttaa cttggaaaga agtgttacaa aaagggctta
    19381 tcttggcaag ttttaacttt ccttggttct tcctcatgtt agccattctt gtcctcattg
    19441 tgatggttct ttatctgtcc gccttcagtc tactcttagg tggctcagtc ttcctacttt
    19501 ttgggtttgg actattggtc tttatccaga ctggattgat ggagaaaatt ttcgcaaaat
    19561 accaatagga gccttatttc tgaaactact ttcaaaggct ccaaacgcta ttctataagc
    19621 gagaaactaa aatctaagtg tctataagat attgaaagcc ttttcggtaa agtgtatact
    19681 aaagaagtaa agaaaaatct gctttagcag aaaataaaaa taataggaga aaatctatgt
    19741 cagatttgaa aaaatacgaa ggtgtcattc cagccttcta cgcatgttat gatgatcaag
    19801 gagaagtaag cccagaacgt acgcgtgcct tggttcaata cttcattgat aaaggtgttc
    19861 aaggtcttta tgtcaatggt tcttctggtg aatgtatcta ccaaagcgtt gaagatcgca
    19921 agttgatttt ggaagaagtc atggcggtag ctaaaggtaa attgaccatt attgcccatg
    19981 ttgcctgcaa caatactaaa gacagtatgg aacttgctcg ccatgctgaa agcttgggag
    20041 tagatgctat tgcaacgatt ccaccaattt atttccgctt gccagaatac tcagttgcca
    20101 aatactggaa cgatatcagt tctgcagctc caaacacaga ctacgtgatt tacaacattc
    20161 ctcaattggc aggggttgct ttgactccaa gcctttacac agaaatgttg aaaaatcctc
    20221 gtgttatcgg tgttaagaac tcttctatgc cagttcaaga tatccaaacc tttgtcagcc
    20281 ttggtgggga agaccatatc gtctttaatg gtcctgatga gcagttccta ggaggacgcc
    20341 tcatgggggc tagggctggt atcggtggta cttatggtgc tatgccagaa ctcttcttga
    20401 aactcaatca gttgattgcg gataaggacc tagaaacagc gcgtgaattg cagtatgcta
    20461 tcaacgcaat cattggtaaa ctcacttctg ctcatggaaa tatgtacggt gtcatcaaag
    20521 aagtcttgaa aatcaatgaa ggcttgaata ttggatctgt tcgttcacca ttgacaccag
    20581 taactgaaga agatcgtcca gttgtagaag cggctgcagc cttgattcgt gaaaccaagg
    20641 agcgcttcct ctaatctaaa aggaggtatt tatgacatac tacgttgcaa ttgatatcgg
    20701 tggaactaac atcaagtatg gtttggttga tcaagagggg caacttcttg aatcgcatga
    20761 aatgccaact gaggcgcata agggtggacc tcatatctta caaaagacca aagatatcgt
    20821 agctagttat ttagaaaaag gcccagtagc aggtgttgcc atatcttctg ctgggatggt
    20881 ggatccggat aagggtgaga ttttctatgc tgggccgcaa atccctaact acgcaggcac
    20941 ccagttcaaa aaggaaatcg aagaaagctt tactattcct tgtgagattg aaaatgatgt
    21001 caactgtgca ggtcttgctg aggcagtatc tggttcaggc aagggagcaa gtgtgacact
    21061 ttgcttgacc attggaacag gtatcggtgg ttgcttgatt atggatagga aagtcttcca
    21121 tggttttagt aattcagcct gtgaagtcgg gtatatgcat atgcaggatg gagcttttca
    21181 agacttggct tctacaacag ctttagtgaa atatgtagct gaagcccatg gagaagatgt
    21241 tgatcagtgg aatggccgac gtatctttaa ggaagctact gaaggaaaca aaatctgcat
    21301 ggaaggtatt gaccgtatgg ttgactatct aggaaaaggt ctggcaaata tttgctacgt
    21361 tgccaatcca gaagtggtca ttcttggtgg tggtatcatg gggcaagagg ctatcctcaa
    21421 acctaagatc cgcacagcct tgaaagaggc tttggtacca agtttagcag aaaaaacacg
    21481 attagaattt gcccatcacc aaaatacagc agggatgttg ggtgcatatt atcattttaa
    21541 gacaaaacaa tcctagtttg gctcagccaa actaggattt tcttacacgt ttttgtctac
    21601 gatagccgtt gagtttttta ttttcccagt agctattaaa gattttttcc ttgctttcgc
    21661 gattgatttc caaaaagtag gcataaatca aatcgataaa gaagagcata ggaagttgag
    21721 cggatattcg ttggatgtag gagggttggc tgtgggtggc tacaagaaca gtctctgtat
    21781 aggtctgact atctttattg ggaacacttg taaagagtac agtctttgcc cccatctcct
    21841 tggcatctaa tagactatct aaaatagaag gagttgagcc tgaaagtgag aaacccagta
    21901 ctagacaatt ttcatccatg atgctggttg tccaggcaaa gccgtcttgg tctgtcaaag
    21961 cttcgcagac cacacctagt cgcataaaac gtaatttcat ttcacgggcg acgaggccag
    22021 aactccctgt tccaaagaag tagatacgct cagcatcttc gattagctgg gcaattcgct
    22081 ctagttggat ttcgtcaatc aagtcttgtg tttgttccct catattgcta taacttctga
    22141 ggactcgttt ggtcagtgga ctatgcttgg agacttggtt ggcttgattt tctgcctgat
    22201 gttggtattg gaaaataaat tctcggtagc cagtaaagcc acacttttta gcaaagcggg
    22261 tcaaagcagc ttgagaaata tgtaattttt gggtgacttg ttgagaagat aaatcatctg
    22321 taatcgtttc agcttgcaaa aaatagcgag cgatttcttg ctctaggtct gtcatttctt
    22381 caaaatgtga atcaatgata gttgcgatat ctggtttgtc catagggaaa gctcctttac
    22441 atgggtcata ctggaagact agatcaggga atagtcacac ttcattataa cacataatat
    22501 aaggatagat aaataaaaac gcatctctgt tttaaaaacg aaaaaatcga aaaagcttct
    22561 ctcttttcca taattttcta ctcaaattgt ggtacaatta agagtaagat tttaagttag
    22621 aaatgagact gatttgtatg agaaaattta acagccattc gattccgatt cggcttaatt
    22681 tattgttttc aatcgtcatt ttactcttta tgaccattat tggtcgtttg ttgtatatgc
    22741 aggttttgaa caaggatttt tacgaaaaaa agctagcctc agctagtcag accaagatta
    22801 caagcagttc agcccgtggg gaaatttatg atgctagtgg aaaacctttg gtagaaaata
    22861 cgttaaagca ggttgtttcc tttacgcgta gcaataaaat gacggctaca gacttaaaag
    22921 aaacagctaa aaagttactg acttatgtga gcatcagttc tccaaatttg acagaacgcc
    22981 agctggcgga ttactatttg gctgatcctg aaatctataa aaaaacagtg gaagctctcc
    23041 caagcgagaa acgcttggat tcagatggca atcgtctatc cgaatcagaa ctgtataaca
    23101 atgcggtcga tagtgtacaa acgagtcaac taaactatac agaggatgaa aagaaagaaa
    23161 tctatctttt tagtcagtta aatgctgttg gaaactttgc gacaggaacc attgcgacag
    23221 atcctctaaa tgattctcag gtggctgtta ttgcctctat ttcaaaggag atgcctggca
    23281 ttagtatttc tacttcttgg gatagaaagg ttttggaaac ttccctttct tctatagttg
    23341 ggagtgtatc cagtgaaaaa gctggtctcc cagcggaaga agcagaagcc tatcttaaaa
    23401 aaggctattc tctaaatgat cgtgtaggaa cctcctattt ggaaaagcaa tatgaagaga
    23461 ccttacaagg aaaacgctcg gtaaaagaaa tccatctgga taaatatggc aatatggaaa
    23521 gcgtggacac aattgaggaa ggtagtaagg gaaacaatat caaactgacc attgatttgg
    23581 ccttccaaga tagcgtggat gctttgctga aaagttattt caattccgag ctaggaaatg
    23641 gcggagccaa gtattctgaa ggtgtctatg cagtcgccct taaccccaaa acaggtgctg
    23701 ttttgtctat gtcaggactc aaacatgacc tgaaaacggg agagttgact cctgattcct
    23761 tgggaacggt aaccaatgtc tttgtcccag gttcggttgt taaggccgct accatcagct
    23821 caggttggga aaatggtgtt ttatcaggaa accaaacctt aacagatcag cctattgttt
    23881 tccaaggttc agctccaatt tattcttggt ataaattggc atatggatct tttcctatta
    23941 cagctgtgga agccttggag tattcatcca atgcttacat ggttcaaacc gctcttggaa
    24001 tcatgggcca gacctatcaa ccaaatatgt ttgtcggcac cagcaatcta gagtctgcta
    24061 tggagaaact gcgttcaacc tttggcgaat atggcttggg tactgcgaca ggaattgacc
    24121 taccagatga atctactgga tttgttccca aagagtatag ctttgctaat tacattacta
    24181 atgcctttgg gcagtttgat aactatacgc cgatgcagtt ggctcagtat gtagcaacta
    24241 ttgcaaataa tggtgttcgt gtggctcctc gtattgttga aggcatttat ggtaataatg
    24301 ataagggagg actgggtgac ttgattcagc aactgcaacc gacagagatg aataaggtca
    24361 atatatccga ctccgatatg agcatcttgc accaaggttt ttatcaggtt gcccatggga
    24421 ctagtggatt gacaactgga cgtgcctttt caaatggcgc agcggtatcc attagtggaa
    24481 aaacaggtac tgccgaaagt tatgttgagg gtggtcaaga agctaacaat actaatgctg
    24541 tggcctatgc accatcagat aatcctcaaa tcgctgtagc tgttgtcttc cctcataaca
    24601 ccaaccttac aaatggtgtc ggaccttcca ttgcgcgcga tattatcaac ctctataacc
    24661 aacatcatcc aatgaattag aaaggaacat atgctttatc caacacctat tgctaagttg
    24721 attgacagtt attctaagtt accaggtatc gggattaaga cggctacgcg tctggccttt
    24781 tatacgattg ggatgtctgc tgatgatgtc aatgaatttg caaaaaatct cctttctgct
    24841 aagagagaat tgacatattg ttctatttgt ggacgtttga cagacgacga tccttgttct
    24901 atctgtactg atccgactcg tgaccagaca acaattttag ttcttgagga tagtagagat
    24961 gtggcagcca tggaaaatat ccaagaatac catggactct atcatgtcct tcatggcctc
    25021 atttctccta tgaatggtat cagtccggac gatatcaatc tcaagagcct tatgactcgt
    25081 cttatggata gtgaagtttc agaagtgatt gtggcgacta atgctacagc ggatggtgaa
    25141 gcgacttcca tgtatctttc acgtttgctc aagccggctg gtatcaaggt tacgcgtcta
    25201 gcacgaggtc tcgctgtggg agcggacatt gagtatgcgg acgaagtgac actcttacga
    25261 gcgattgaaa atcggacaga gttgtaagtg taggcaaatt tacgaactcc attcatttat
    25321 aaaaaatcaa agaggctgaa aatcgttcct atcggcctct ttttgtatag tgtgatgagt
    25381 aggatcaggt tcaagtttta aaaaaccaag caaatatgat atactaaaga gcgagtattc
    25441 tagtagaatt aggacaaata atatgaaaca aacgattatt cttttatatg gtggacggag
    25501 tgcggaacgc gaagtctctg tcctttcagc tgagagtgtc atgcgtgcgg tcaattacga
    25561 ccgtttcaca gtcaagactt tctttatcag tcagtcaggt gactttatca aaacacagga
    25621 atttagtcat gctccggggc aagaagaccg tctcatgacc aatgaaacca ttgattggga
    25681 taagaaagtt gcaccaagtg ctatctacga agaaggtgca gtggtctttc cagtccttca
    25741 cgggccaatg ggagaagatg gctctgttca aggattcttg gaagttttga aaatgcctta
    25801 cgttggttgc aacattttgt catcaagtct tgccatggat aaaatcacga ctaagcgtgt
    25861 tctggaatct gctggtattg cccaagttcc ttatgtggct atcgttgaag gcgatgatgt
    25921 gactgctaaa atcgctgaag tggaagaaaa attggcttat ccagtcttca ctaagccgtc
    25981 aaacatgggg tctagtgtcg gtatttctaa gtctgaaaac caagaagaac tccgtcaagc
    26041 cttaaaactt gccttccgat atgacagccg tgtcttggtt gagcaaggag tgaatgcccg
    26101 tgaaattgag gttggcctct tgggtaacta cgatgtcaag agcacgctac ctggagaagt
    26161 tgtcaaggac gttgcctttt atgactacga tgccaagtat attgataaca agattactat
    26221 ggatattcct gccaaaatca gtgatgatgt ggtggctgtc atgcgtcaaa atgcagaaac
    26281 agccttccgt gccattggtg gccttggtct atctcgttgc gatttcttct atacagataa
    26341 gggagagatt tttctcaacg agctcaatac catgccaggt tttacccagt ggtctatgta
    26401 cccactactt tgggacaata tggggatcag ctacccagaa ctaatcgagc gtttggttga
    26461 ccttgccaag gaaagttttg acaagcgcga agcgcatttg atataaaatg aaagagaggg
    26521 tagaagccag aaccatcact gcacggtgac tagagttctc ggacttcagc cctttttaaa
    26581 ggagtagaaa tgaaattaac aatccatgaa attgcccaag ttgttggagc caaaaatgat
    26641 atcagtatct ttgaggacac ccagttagaa aaagctgagt ttgatagtcg tttgattgga
    26701 actggagatt tatttgtgcc acttaaaggt gcgcgtgatg gccatgactt tattgaaaca
    26761 gcctttgaaa atggtgcagc agtaaccttg tctgagaaag aggtctcaaa tcatccttac
    26821 attctagtag atgatgtttt gacagccttt caatccctag catcctacta tcttgaaaaa
    26881 acgactgttg atgtctttgc tgttacaggt tcaaatggca agacaacgac taaggatatg
    26941 ttggcgcatt tactgtcaac aagatacaag acctacaaaa cacaaggcaa ttacaataat
    27001 gagattggcc ttccttacac agttctccac atgcctgaag gaacagaaaa gttggtcttg
    27061 gagatggggc aggaccactt gggagatatt catctcttgt ctgaattggc tcgtccaaaa
    27121 acagccatcg tgaccttggt tggagaagct catttggcct ttttcaaaga tcgttctgag
    27181 attgctaaag gaaaaatgca aattgcagac ggaatggctt caggttcctt gcttttagcg
    27241 ccggctgacc ctatcgtaga ggactatttg ccaactgata aaaaggtggt tcgttttggt
    27301 caaggagcag agctggaaat tactgacttg gttgagcgca aagatagtct gaccttcaag
    27361 gccaatttct tagagcaagt ccttgatttg ccagtaactg gcaagtataa tgcgacaaat
    27421 gctatgattg catcctatgt tgccttgcaa gaaggagttt cagaggagca aattcatcag
    27481 gccttccaag atcttgaatt gacgcgtaac cgtaccgaat ggaagaaagc agccaatgga
    27541 gcagatatcc tgtctgatgt atacaatgcc aatccaactg ctatgaagtt gattttagag
    27601 actttctctg ccattccagc caatgaaggt ggcaagaaaa ttgcggtttt agcggacatg
    27661 aaggaactgg gtaaccagtc agttcaactt cataatcaga tgattttgag cctttctcca
    27721 gatgtgcttg ataccgtgat tttctatgga gaagacattg ctgaattagc ccaattggcc
    27781 agtcaaatgt tcccaattgg ccacgtttac tacttcaaga aaacagaaga ccaagaccaa
    27841 tttgaagacc tagtcaagca ggtcaaggaa agcctcagtg ccaatgatca aatcttgctc
    27901 aagggctcta actctatgaa cctagctatg ttggtagaaa gtttagaaaa tgaaaccaag
    27961 tgattttgtt aagtatctgc aaagaatgat tgcccttaca gatactggct taacctttac
    28021 aaaagatcct tttgaccgtg agcgctacga ggacttgcga agtctgttat ctgaaatgtt
    28081 gaatcaggga tcagacctgg atgcagaaga agtagcagaa gtcttgaaac caacttcagc
    28141 ttatgcgact cccttaatgg acgtccgtgc ttggattgtt gaggatgaga agatttgtct
    28201 ggttagggga caaggagagg gtagttgggc tttgccaggt ggctttggtg aagtcggcta
    28261 ttctccaact gaaaatattc tcaaggaaat tgaagaagaa accggtttta aagccaaagt
    28321 tgaaagactg ctagctgttt ttgatatcaa tcgtttccaa ctacagagca aacaatatgc
    28381 aaagtttgtt tttgaatgta agcttctcga tggacaattc caagaaaatc aagaaattgc
    28441 agaccttcaa ttttttgcca ttgatcaact gccagtctta tctgaaaaac gcattaccaa
    28501 ggagcaaata gagattcttt ggcaggttta tcaaggtcag agggagcaat atcttgacta
    28561 agaagatgat tatcgtattt ttaaatccat ttttaacaac tagcatggta taataatatg
    28621 caggaaaatt ttgaattatg aggaagacta gatgaattta tgggatattt tctttacgac
    28681 tcaggcaacc aagccgccca aatttgacct tttttggtat gttagcctat ttacgctctt
    28741 agccttaacc ttttatacag cccatcgcta tcgtgaaaag aaggtttacc aacgattttt
    28801 ccaaatcttg cagactgttc agttaatcct tctttatggt tggtactggg tcaatcatat
    28861 gccactgtca gaaagcctac ccttttacca ttgccgtatg gctatgtttg tggtactctt
    28921 gcttcctggt caatccaaat ataaacaata ctttgcatta ttgggaacat ttgggacatt
    28981 agcagccttt gtttatccag tgccagatgc ttaccctttt ccacatatca ccattctatc
    29041 ctttatcttt ggtcatttag cactcttggg gaactctcta gtttatctat tgagacagta
    29101 taatgcgcga ttgctggatg tgaagggaat ttttctcatg acctttgccc taaatgcctt
    29161 gatttttgtg gtcaatttgg tgacaggtgg cgattacgga tttttgacaa aaccgccatt
    29221 ggttggggat cacggtctag tagctaatta tttacttgtt tcaattgtgc tggtagctac
    29281 tatcagtttg actaagaaaa tcttagaatt ctttttagct caagaagcag aaaaaatgat
    29341 tgtaaaggaa gcttaacaca gagctttctt ttttgctctt agagagtttt tacaatcagc
    29401 ttataaaata agaatttctg aatagacaaa ctcaaaaaat ggctgggaaa tttaggaaaa
    29461 aagcaagcac gattaaattt tttgtgttat aatattttgt gaatagctat gcctatgttt
    29521 agctatggaa taatacgaag tgcgaaactt ggaagataga gaggaagcga tgtaatggct
    29581 agagaaggct tttttacagg tctagatatt ggaacaagct ctgtcaaggt gcttgtggcc
    29641 gagcagagaa atggtgaatt aaatgtaatt ggcgtgagta atgccaaaag taaaggtgta
    29701 aaggatggaa ttattgttga tattgatgca gcagcaactg ctatcaagtc agccatttcc
    29761 caagcggaag aaaaggcagg catttcgatt aaatcagtaa atgtcggctt gcctggtaat
    29821 cttttgcagg tagaaccaac tcaggggatg attccagtaa catctgatac taaggaaatt
    29881 acggatcaag atgttgaaaa tgttgtcaaa tcagctttga caaagagtat gacacctgac
    29941 cgtgaagtca ttacctttat tcctgaagaa tttattgtgg atggtttcca agggattcgt
    30001 gacccacgtg gcatgatggg ggttcgcctt gaaatgcgtg gtttgcttta tacaggacct
    30061 cgtactatct tgcacaattt gcgtaagacg gttgagcgtg caggtgttca ggttgaaaat
    30121 gttatcattt caccactagc aatggttcag tctgttttga acgaagggga acgtgaattt
    30181 ggtgctacag tgattgatat gggggcaggt caaacgactg tcgctacaat ccgtaatcaa
    30241 gaactccagt tcacacatat tctccaagaa ggtggagatt atgtaactaa agatatctcc
    30301 aaggttttga aaacctctcg caaattagcg gaaggcttga aactgaatta cggggaagcc
    30361 tatccgcctc ttgcaagcaa agaaaccttc caagtagagg ttattggaga agtagaagca
    30421 gtcgaagtga cggaagccta cttgtcagaa attatttctg cacgaatcaa gcacatcctt
    30481 gaacaaatca agcaagaatt agatagaagg cgtctattgg acctccctgg tggtattgtc
    30541 ttaatcggtg ggaatgccat tttaccaggt atggttgagc ttgctcagga agtctttggc
    30601 gtccgtgtca agctttatgt tccaaatcaa gttggtatcc gtaatccagc ctttgcgcat
    30661 gtgattagtt tatcagaatt tgcgggtcaa ttaacagaag ttaatctttt ggctcaggga
    30721 gcgataaaag gtgagaatga cttaagtcat cagccaatta gttttggtgg gatgctgcaa
    30781 aaaacagctc agtttgtaca atcaacgcct gttcaaccag ctcctgctcc agaagtagag
    30841 ccggtggcgc ctacagaacc aatggcggat ttccaacaag cttcacaaaa taaaccgaaa
    30901 ttagcagatc gtttccgtgg cttgatcgga agcatgtttg acgaataaag aggaaaaata
    30961 aattatgaca ttttcatttg atacagctgc tgctcaaggg gcagtgatta aagtaattgg
    31021 tgtcggtgga ggtggtggca atgccatcaa ccgtatggtc gacgaaggtg ttacaggcgt
    31081 agaatttatc gcagcaaaca cagatgtaca agcattgagt agtacaaaag ctgagactgt
    31141 tattcagttg ggacctaaat tgactcgtgg tttgggtgca ggaggtcaac ctgaggttgg
    31201 tcgtaaagcc gctgaagaaa gcgaagaaac actgacggaa gctattagtg gtgccgatat
    31261 ggtcttcatc actgctggta tgggaggagg ctctggaact ggagctgctc ctgttattgc
    31321 tcgtattgcc aaagatttag gtgcgcttac agttggtgtt gtaacacgtc cctttggttt
    31381 tgaaggaagt aagcgtggac aatttgctgt agaaggaatc aatcaacttc gtgagcatgt
    31441 agacactcta ttgattatct caaacaacaa tttgcttgaa attgttgata agaaaacacc
    31501 gcttttggag gctcttagcg aagcggataa cgttcttcgt caaggtgttc aagggattac
    31561 cgatttgatt accaatccag gattgattaa ccttgacttt gccgatgtga aaacggtaat
    31621 ggcaaacaaa gggaatgctc ttatgggtat tggtatcggt agtggagaag aacgtgtggt
    31681 agaagcggca cgtaaggcaa tctattcacc acttcttgaa acaactattg acggtgctga
    31741 ggatgttatc gtcaacgtta ctggtggtct tgacttaacc ttgattgagg cagaagaggc
    31801 ttcacaaatt gtgaaccagg cagcaggtca aggagtgaac atctggctcg gtacttcaat
    31861 tgatgaaagt atgcgtgatg aaattcgtgt aacagttgtt gcaacgggtg ttcgtcaaga
    31921 ccgcgtagaa aaggttgtgg ctccacaagc tagatctgct actaactacc gtgagacagt
    31981 gaaaccagct cattcacatg gctttgatcg tcattttgat atggcagaaa cagctgaatt
    32041 gccaaaacaa aatccacgtc gtttggaacc aactcaggca tctgcttttg gtgattggga
    32101 tcttcgccgt gaatcgattg ttcgtacaac agattcagtc gtttctccag tcgagcgctt
    32161 tgaagcccca atttcacaag atgaagatga attggataca cctccatttt tcaaaaatcg
    32221 ttaagtaaat gaatgtaaaa gaaaatacag aacttgtttt tcgagaagtt gcagaggcta
    32281 gtctgagtgc tcatcgagag agtggttcgg tctctgtcat tgcagttacc aagtatgtag
    32341 atgtaccgac agcggaagcc ttgcttccgc taggtgttca tcatatcggt gaaaatcgtg
    32401 tagataagtt tctggaaaaa tatgaagctt taaaagatcg agatgtgact tggcatttga
    32461 ttggtacctt gcaaagacgt aaggtgaaag atgtcattca atacgttgat tatttccatg
    32521 cattggactc agtaaagcta gcaggggaaa ttcaaaaaag aagtgaccga gtcatcaagt
    32581 gtttccttca agtaaatatt tctaaagaag aaagcaaaca cggtttttcg agagaggaac
    32641 tgctggaaat cttgccagag ttagccagac tagataagat tgaatatgtt ggtttaatga
    32701 cgatggcacc ttttgaggct agcagtgagc agttgaaaga gattttcaag gcggcccaag
    32761 atttacaaag agaaattcaa gagaaacaaa ttccaaatat gcctatgacc gagttaagta
    32821 tgggaatgag tcgtgattat aaagaagcga ttcaattcgg ttccactttt gttcgtatag
    32881 gtacatcatt ttttaagtag gagagaacca tgtctttaaa agatagattc gatagattta
    32941 tagattattt tacggaggat gaggattcaa gtctccctta tgaaaaaaga gatgagcctg
    33001 tgtttacttc agtaaattct tcacaggaac cggctctccc aatgaatcaa ccttcacagt
    33061 cggctggtac aaaagagaac aatatcacca gacttcatgc aagacaacag gaattggcaa
    33121 atcagagtca gcgtgcaacg gataaggtca ttatagatgt tcgttatcct agaaaatatg
    33181 aggatacaac agaaattgtt gatttattgg caggaaacga aagtatcttg attgactttc
    33241 agtatatgac agaggtgcag gctcgtcgtt gtttggacta tttggatgga gcttgtcatg
    33301 ttttagctgg aaatttgaaa aaggtagctt ctaccatgta tttgttgaca ccagtgaacg
    33361 ttattgtaaa tgttgaagat atccgtttac cagatgaaga tcaacagggt gagttcggtt
    33421 ttgatatgaa gcgaaataga gtacgataat gattttttta attcgtatga tttataatgc
    33481 agtggatatt tactccctga ttttggtagc cttcgctgtc atgtcttggt ttccaggtgc
    33541 ctacgaatcc agtttaggtc gttggattgt agcgttggtg aaaccagtgc ttgctccctt
    33601 gcaacgcctg cctttacaga tagcgggtct tgatttatct gtttgggttg cgattgtttt
    33661 ggttcgattt ttaggagaaa acctagtgcg ttttctggcg atgataggat gaataaaggg
    33721 atttatcagc atttctccat agaagatcgt ccatttcttg acaagggaat ggaatggata
    33781 aagaaggtag aagatagcta tgctcctttt ttaactcctt ttatcaatcc tcatcaggag
    33841 aagctattaa agattttggc caaaacctat ggtcttgctt gtagcagtag tggggaattc
    33901 gtctcgagtg agtatgttcg agttttatta tacccagatt atttccaacc agagttttca
    33961 gattttgaaa tatctctcca ggaaattgtg tattccaata aatttgaaca tttaacgcat
    34021 gctaagattt tagggacagt catcaatcaa ttagggattg aacggaaact ttttggagat
    34081 atcctagtag atgaagaacg ggcgcagatt atgattaatc agcagtttct tcttctcttt
    34141 caagatggac taaagaaaat tggtcgtata cctgtttcgc tggaggaacg tcctttcacc
    34201 gagaaaatag ataagctaga acagtatcga gaactggatt tatctgtgtc tagttttcga
    34261 ttagatgttc ttttatcaaa tgttttgaaa ctatctagga atcaagcaaa ccagttgatt
    34321 gaaaagaaac ttgtccaagt aaattatcat gtggtagaca aatcagatta cactgttcaa
    34381 gttggagact tgattagtgt gagaaaattt ggtcgcttga gattacttca agataaggga
    34441 caaacgaaaa aagagaagaa aaaaataacc gtccagttat tattaagtaa gtgaggaata
    34501 gaatgccaat tacatcatta gaaataaagg acaagacttt tggaactcga ttcagaggtt
    34561 ttgatccaga agaagtcgat gaatttttag atattgtggt tcgtgattac gaagatcttg
    34621 tgcgtgcgaa tcatgataaa aatttgcgta ttaagagttt agaagagcgt ttgtcttact
    34681 ttgatgaaat aaaagattca ttgagccagt ctgtattgat tgctcaggat acagctgaga
    34741 gagtgaaaca ggcggcgcat gaacgttcaa acaatatcat tcatcaagca gagcaagatg
    34801 cgcaacgctt gttggaagaa gctaaatata aggcaaacga gattcttcgt caagcaactg
    34861 ataatgctaa gaaagtcgct gttgaaacag aagaattgaa gaacaagagc cgtgtcttcc
    34921 accaacgtct caaatctaca attgagagtc agttggctat tgttgaatct tcagattggg
    34981 aagatattct ccgtccaaca gctacttatc ttcaaaccag tgatgaagcc tttaaagaag
    35041 tggttagcga agtacttgga gaaccgattc cagctccaat tgaagaagaa ccaattgata
    35101 tgacacgtca gttctctcaa gcagaaatgg cagaattaca agctcgtatt gaggtagccg
    35161 ataaagaatt gtctgaattt gaagctcaga ttaaacagga agtggaaact ccaactcctg
    35221 tagtgagtcc tcaagttgaa gaagagcctc tgctcatcca gttggcccaa tgtatgaaga
    35281 accagaagta gctccagtgc atccgacagg tccaacacca gctacagaaa ctgttgattc
    35341 agcaccggga tttgaagcac cgcaagaatc tgttacaatt ttataagaaa tattctgaga
    35401 acaatatctt atccttatat tcccagcgag caggagatgg tgtgagtcct gcattcccta
    35461 tcgataagat tatcctctca aactatcaag tctgaatcta gtaagatttg acgttcccca
    35521 cgttacggga taagagggag aaagactaaa actttttccg aataaaggtg gtaccacgat
    35581 tttcgtcctt tttggaagtc gtggttttta atttgttatt atttataaag gagataccat
    35641 gaaactcaaa gacaccctta atcttgggaa aactgaattc ccaatgcgtg caggccttcc
    35701 taccaaagag ccagtttggc aaaaggaatg ggaagatgca aaactttatc aacgtcgtca
    35761 agaattgaac caaggaaaac ctcatttcac cttgcatgat ggccctccat acgctaacgg
    35821 aaatatccac gttggacatg ctatgaacaa gatttcaaaa gatattattg ttcgttctaa
    35881 gtctatgtca ggattttacg caccatttat tcctggttgg gatactcatg gtctgccaat
    35941 cgagcaagta ttgtcaaaac aaggtgtcaa acgtaaagaa atggacttgg ttgagtactt
    36001 gaaactttgc cgtgagtacg ctctttctca agtagataaa caacgtgaag attttaaacg
    36061 tttgggtgtt tctggtgact gggaaaatcc atatgtgacc ttgactcctg actatgaagc
    36121 agctcaaatt cgtgtatttg gtgagatggc taataagggt tatatctacc gtggtgccaa
    36181 gccagtttac tggtcatggt catctgagtc agcccttgct gaagcagaga ttgaatacca
    36241 tgacttggtt tcaacttccc tttactatgc caacaaggta aaagatggca aaggagttct
    36301 agatacagat acttatatcg ttgtctggac aacgactcca tttaccatca cagcttctcg
    36361 tggtttgacg gttggtgcag atattgatta cgttttggtt caacctgttg gtgaagctcg
    36421 taagtttgtc gttgctgctg aattattgac tagcttgtct gagaaatttg gctgggctga
    36481 tgttcaagtt ttggaaactt accgtggcca agaactcaac cacatcgtaa cagaacaccc
    36541 atgggataca gctgtagaag agttggtaat tcttggtgac cacgttacga ctgactctgg
    36601 tacaggtatt gtccatacag cccctggttt tggtgaggac gattacaatg ttggtattgc
    36661 taataatctt gaagtcgcag tgactgttga tgaacgtggt atcatgatga agaatgctgg
    36721 tcctgaattt gaaggtcaat tctatgaaaa ggtagttcca actgttattg aaaaacttgg
    36781 taacctcctt cttgcccaag aagaaatctc tcactcatat ccatttgact ggcgtactaa
    36841 gaaaccaatc atctggcgtg cagttccaca atggtttgcc tcagtttcta aattccgtca
    36901 agaaatcttg gacgaaattg aaaaagtgaa attccactca gaatggggta aagtccgtct
    36961 ttacaatatg atccgtgatc gtggtgactg ggttatctct cgtcaacgta cttggggtgt
    37021 tccacttcct atcttctacg ctgaagatgg tacagctatc atggtagctg aaactattga
    37081 acacgtagct caactttttg aaaaacatgg ttcaagcatt tggtgggaac gtgatgccaa
    37141 agacctcttg ccagaaggat ttactcatcc aggttcacca aacggcgagt tcaaaaaaga
    37201 aactgatatc atggacgttt ggtttgactc aggttcatca tggaatggag tggtggtaaa
    37261 ccgtcctgaa ttgacttacc cagccgacct ttacctagaa ggttctgacc aataccgtgg
    37321 ttggtttaac tcatcactta tcacatctgt tgccaaccat ggcgtagcac cttacaaaca
    37381 aatcttgtca caaggttttg cccttgatgg taaaggtgag aagatgtcta aatctcttgg
    37441 aaatactatt gctccaagcg atgttgaaaa acaattcggt gctgaaatct tgcgtctctg
    37501 ggtaacaagt gttgactcaa gcaatgacgt gcgtatctct atggatatct tgagccaagt
    37561 ttctgaaact taccgtaaga ttcgtaacac tcttcgtttc ttgattgcca atacatctga
    37621 ctttaaccca gctcaagata cagtcgctta cgatgagctt cgttcagttg ataagtacat
    37681 gacgattcgc tttaaccagc ttgtcaagac cattcgtgat gcctatgcag actttgaatt
    37741 cttgacgatc tacaaggcct tggtgaactt tatcaacgtt gacttgtcag ccttctacct
    37801 tgattttgcc aaagatgttg tttacattga aggtgccaaa tcactggaac gccgtcaaat
    37861 gcagactgtc ttctatgaca ttcttgtcaa aatcaccaaa ctcttgacac caatccttcc
    37921 tcacactgcg gaagaaattt ggtcatatct tgagtttgaa gccgaagact tcgtccaatt
    37981 gtcagaatta ccagaggctc aaacttctgc taaccaagaa gaaatcttgg atacatgggc
    38041 agccttcatg gacttccgtg gacaagcaca aaaagccttg gaagaagctc gtaatgcaaa
    38101 agttatcggt aaatcacttg aagcacactt gacagtttat ccaaatgaag tggtgaaaac
    38161 tctactcgaa gcagtaaaca gcaatgtagc tcaacttttg atcgtgtctg agttgaccat
    38221 cgcagaagaa ccaactccgg aagctgccct tagcttcgaa gatgtagcct tcacagttga
    38281 acgtgctgct ggtgaagtat gtgaccgttg ccgtcgtatc gacccaacaa cagcagaacg
    38341 cagctaccag gcagttatct gtgaccactg tgcaagcatc gtagaagaaa attttgcgga
    38401 tgcagtcgca gaaggatttg aagagaaata agattgaaaa gtctaggcaa aattcaattt
    38461 gagaagaaaa gacaactaat tttatagtct attaaacgca ttgtatcacg tttttgaaca
    38521 cctgatatga tgcgttttta tttattttga aaatttgtga ggtgtgactt tttatactca
    38581 acaagaatca aagagaaact tagcaagcta acagtagtaa gataaaatag gaatttgata
    38641 ttagggataa gattggtaaa tagtgtaata tttttacaac aataaattta tatagttatt
    38701 tctggt
//
LOCUS       DBERMM010000017        36852 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.017, whole genome shotgun sequence.
ACCESSION   DBERMM010000017 DBERMM010000000
VERSION     DBERMM010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 36852)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36852)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36852
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.017"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            93..455
                     /locus_tag="ACL8AS_001092"
     CDS             93..455
                     /locus_tag="ACL8AS_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000842495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228967.1"
                     /translation="MKSSGIVGLVGGILLLICPFVLLGTAVNTAATTLNGGATAGAFS
                     GVALLLNALKIANLVLGIIAIVYYKGDKRVGAAPSVLMIVSGEVSLIPFLGWVGGILA
                     IIGGSLFLATLKKFKSEE"
     gene            990..1682
                     /locus_tag="ACL8AS_001093"
     CDS             990..1682
                     /locus_tag="ACL8AS_001093"
                     /EC_number="5.4.2.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate mutase"
                     /protein_id="HGS1228968.1"
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIK
                     EAGIKFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAA
                     EQFGDEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERAL
                     PFWEDKIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDE
                     KLNVVSEYYLGK"
     gene            1735..4146
                     /locus_tag="ACL8AS_001094"
     CDS             1735..4146
                     /locus_tag="ACL8AS_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HGS1228969.1"
                     /translation="MIRNKKQDYVLAYKQPASTTYMGWEEEALPIGNGSLGAKVFGRI
                     GAERIQFNEKSLWSGGPLPDSSDYQGGNLQDQYVFLAEIRQALEKRDYNLAKELAEQH
                     LIGPKTSQYGTYLSFGDIHIEFSQQGTTLSQVTDYQRQLNISKALATTSYVYKGTRFE
                     RKAFASFPDDLLVQCFTKEGLETLDFTIELSLTCDLASDGKYEQEKSDYKECKLDITD
                     SHILMKGRVKDNDLRFASYLAWETDGDIRVWSDRVQISGASYANLFLAAKTDFAQNPA
                     SNYRKKLDLEQQVIDLVDTAKEKGYTQLKSRHIEDYQALFQRVQLDLEADVDASTTDD
                     LLKNYKPQEGQALEELFFQYGRYLLISSSRDCPDALPANLQGVWNAVDNPPWNSDYHL
                     NVNLQMNYWPAYVTNLLETVFPVINYVDDLRVYGRLAAVKYAGIVSQKGEENGWLVHT
                     QATPFGWTAPGWDYYWGWSPAANAWMMQTVYEAYSFYRDQDYLREKIYPMLRETVRFW
                     NAFLHKDQQAQRWVSSPSYSPEHGPISIGNTYDQSLIWQLFHDFIQAAQELGLDEDLL
                     TEVKEKSDLLNPLQITQSGRIREWYEEEEQYFQNEKVEAQHRHASHLVGLYPGNLFSY
                     KGQEYIEAARASLNDRGDGGTGWSEANKINLWARLGDGNRAHKLLAEQLKTSTLQNLW
                     CSHPPFQIDGNFGATSGMAEMLLQSHAAYLVPLAALPDAWSTGSVSGLMARGHFEVSM
                     SWEDKKLLQLTILSRSGGDLRVSYPDIEKSVIKMNQEKIKAKCMGKDCISVATAEGDL
                     VQFYF"
     gene            4396..5097
                     /locus_tag="ACL8AS_001095"
     CDS             4396..5097
                     /locus_tag="ACL8AS_001095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1228970.1"
                     /translation="MAYIEMKHCYKRYQVGDTEIVANRDVNFEIEKGELVIILGASGA
                     GKSTVLNLLGGMDTNDEGEIWIDGVNIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTA
                     KENVELASEIVTDALNPDQVLTDVGLAHRLNNFPAQLSGGEQQRVSIARAVAKNPKIL
                     LCDEPTGALDYQTGKQVLKILQDMSRQKGATVIIVTHNGALAPIADRVIHMHDASVKD
                     VVLNQHPQDIDSLEY"
     gene            5099..7807
                     /locus_tag="ACL8AS_001096"
     CDS             5099..7807
                     /locus_tag="ACL8AS_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HGS1228971.1"
                     /translation="MIKRKTYWKDLIQSFTGSKGRFLSILILMMLGSLALVGLKVTSP
                     NMEATANAYLTTAQTLDLAVMSNYGLDQADQEELKQTEGAEVEFGYLTDVTMDNGQDA
                     IRLYSKPERISTFQLRKGRLPQSDKEIALATHLQGQYSVGQEISFKEKEEGHSSLKDH
                     TYTITGFVDSAEILSQRDMGYAGSGSGTLTAYGVILPSQFDQKVYNIARLKYQDLAGL
                     NAFSSAYEEKSKQHQEELEQILSDNGKVRLQLLKKEGQESLDKGQETLDKAQTNLQEG
                     KRRLAAAQARIQAQESQLALFPQVQREQASAQLTQAKQELGKEEAKLKQAEQNLAQEK
                     EKLEKHQQVLDDLAEPRYQVYNRQTMPGGQGYLMYSNASSSIRAVGNIFPVVLYAVAA
                     MVTFTTMTRFVDEERTHAGIFKALGYRSKDIITKFLLYGLVAGTVGTALGSILGHYLL
                     ASVISSVITKGMVVGETQIQFYWTYSLLALVLSLLASVLPAYLVAWRELHAEAAQLLL
                     PKPPVKGAKILLERIGFIWRRLSFTHKVTARNIFRYKQRMLMTIFGVAGSVALLFAGL
                     GIQSSVAGVPSKQFQQIQQYQMLVSENPSATNQDKVELAEVLKGQEILAYQKIYSKTL
                     DKDFKGKAGLQNITLMMIEKEDLTPFIHLQHHQQELTLKDGIVITAKLAQLAGVKVGQ
                     TLEIEGKELKVAAITENYVGHFIYMSQASYEQLYGQLPQANTYLVSLRDTSATSIESQ
                     AGLLMNQSAVSSVVQNASAIRLFDSIASSLNQTMTILVIVSVLLAIVILYNLTNINVA
                     ERIRELSTIKVLGFHNNEVTLYIYRETIVLSLVGIVLGLVAGFYLHQFLIQMISPATI
                     LFYPQVGWEVYVIPVAAVSIILTLLGFFVNYYLRKVDMLEALKSVE"
     gene            complement(7903..8394)
                     /gene="tpx"
                     /locus_tag="ACL8AS_001097"
     CDS             complement(7903..8394)
                     /gene="tpx"
                     /locus_tag="ACL8AS_001097"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008379 - thioredoxin peroxidase activity
                     [Evidence IEA];
                     GO_function: GO:0016684 - oxidoreductase activity, acting
                     on peroxide as acceptor [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiol peroxidase"
                     /protein_id="HGS1228972.1"
                     /translation="MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKK
                     KVLSVVPSIDTGICSTQTRRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGLDNAIM
                     LSDYFDHSFGRDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAA
                     KAL"
     gene            complement(8517..9446)
                     /gene="psaA"
                     /locus_tag="ACL8AS_001098"
     CDS             complement(8517..9446)
                     /gene="psaA"
                     /locus_tag="ACL8AS_001098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding
                     lipoprotein/adhesin PsaA"
                     /protein_id="HGS1228973.1"
                     /translation="MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIAD
                     ITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTK
                     LVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSA
                     KDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVP
                     SAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQ
                     IFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLAK"
     gene            complement(9478..10326)
                     /locus_tag="ACL8AS_001099"
     CDS             complement(9478..10326)
                     /locus_tag="ACL8AS_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000559784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease subunit"
                     /protein_id="HGS1228974.1"
                     /translation="MIAEFIDGLQKFHFLQNALITAIVVGIVAGAVGCFIILRGMSLM
                     GDAISHAVLPGVALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSS
                     FLALGIILIGVAKSSTDLFHILFGNILAVQDTDMFITMGVGAAILLLIWIFFKQLLIT
                     SFDELLAKAMGMPVNFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANS
                     LKSMIFLSSTFGATASVLGLFIGYSFNVAAGSSIVLTAASFFLISFFIAPKQRYLKLK
                     NKHLLK"
     gene            complement(10323..11045)
                     /locus_tag="ACL8AS_001100"
     CDS             complement(10323..11045)
                     /locus_tag="ACL8AS_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HGS1228975.1"
                     /translation="MIRIENLSVSYKETLALKDISLVLHGPTITGIIGPNGAGKSTLL
                     KGMLGIIPHQGQAFLDDKEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPL
                     FRSLKAKHWKKVQEALEIVGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEP
                     FAGIDSVSEEIIMNTLRDLKKAGKTVLIVHHDLSKIPHYFDQVLLVNREVIAFGPTKE
                     TFTETNLKEAYGNQLFFNGGDL"
     gene            11272..13164
                     /gene="pepO"
                     /locus_tag="ACL8AS_001101"
     CDS             11272..13164
                     /gene="pepO"
                     /locus_tag="ACL8AS_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase PepO"
                     /protein_id="HGS1228976.1"
                     /translation="MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLML
                     ATTDKWLAGEEVPEDAILENFVKYHRLVRDFDKREADGITPVLPLLKEFQELETFADF
                     TAKLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELL
                     TLWKESSANLLKAYDFSDEEIEDLLEKRLELDRRVAAVVLSNEESSEYAKLYHPYSYE
                     DFKKFAPALPLDDFFKAVIGQLPDKVIVDEERFWQAAEQFYSEEAWSLLKATLILSVV
                     NLSTSYLTEDIRVLSGAYSRALSGVPEAKDKAKAAYHLAQEPFKQALGLWYAREKFSP
                     EAKADVEKKVATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKD
                     KVVNETASLFENALAFARVEIKHSWSKWNQPVDYKEWGMPAHMVNAYYNPQKNLIVFP
                     AAILQAPFYDLHQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLKDWWTESDYAA
                     FKEKTQKVIDQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFSAEEFFY
                     NFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDGMWRSPE
                     ERVIIW"
     gene            complement(13287..13916)
                     /locus_tag="ACL8AS_001102"
     CDS             complement(13287..13916)
                     /locus_tag="ACL8AS_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HGS1228977.1"
                     /translation="MKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIEKIN
                     KPICAILLTHTHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMA
                     DVVTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETI
                     GRTDLPTGSMEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF"
     gene            14910..17132
                     /locus_tag="ACL8AS_001103"
     CDS             14910..17132
                     /locus_tag="ACL8AS_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019316080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0015968 - stringent response [Evidence
                     IEA];
                     GO_process: GO:0015969 - guanosine tetraphosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RelA/SpoT family protein"
                     /protein_id="HGS1228978.1"
                     /translation="MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYR
                     KSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRVIV
                     DGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ
                     ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALV
                     DEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQS
                     DVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEV
                     AEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAE
                     EIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVE
                     IIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVA
                     NKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAE
                     AEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGR
                     GVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQ
                     VLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG
                     "
     gene            17162..17605
                     /gene="dtd"
                     /locus_tag="ACL8AS_001104"
     CDS             17162..17605
                     /gene="dtd"
                     /locus_tag="ACL8AS_001104"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="HGS1228979.1"
                     /translation="MKIIIQRVKKAQVSIEGQIQGKINQGLLLLVGVGPEDQEEDLDY
                     AVRKLVNMRIFSDAEGKMNLSVKDIEGEILSISQFTLFADTKKGNRPAFTGAAKPDMA
                     SDFYDAFNQKLAQEVPVQTGIFGADMQVELVNNGPVTIILDTKKR"
     gene            complement(17644..18005)
                     /locus_tag="ACL8AS_001105"
                     /pseudo
     CDS             complement(17644..18005)
                     /locus_tag="ACL8AS_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014307.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(18079..18492)
                     /locus_tag="ACL8AS_001106"
     CDS             complement(18079..18492)
                     /locus_tag="ACL8AS_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228980.1"
                     /translation="MKKLYRIHFIAIAVIDLLLFAFFIIRLETSFEWLLLSGLIFFLA
                     QGLLLFLLVVRLKHQFAEIYPQINKKIRFYYLGVLTIDFLFFVLLAFISSQRFSSLMP
                     IITACHSTFYYMTADYLGENYPDFYDKHISLWECL"
     gene            complement(18594..19271)
                     /locus_tag="ACL8AS_001107"
     CDS             complement(18594..19271)
                     /locus_tag="ACL8AS_001107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0034257 - nicotinamide riboside
                     transmembrane transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide mononucleotide transporter family
                     protein"
                     /protein_id="HGS1228981.1"
                     /translation="MVVGIAIASGYLNSRLDKFVDWGLWTALVPFGLISLTNVGISML
                     STRFTGKLSKWGNYFGIVNTILSGAIDYILGNKATIITYPVTFLIYTFAIKKWKASQE
                     GRPNQMSQKQVKLAAIIISIIAFLFAFVTNYIGYGGKMNLLAYVTTIAFALSLIANAL
                     NALKLTTQWGFWLIYNFVQLTKAGIQGNFANIGKYIFYILNAIGALFVWNDEEVRYIE
                     GNSNKEY"
     gene            complement(19448..20098)
                     /locus_tag="ACL8AS_001108"
     CDS             complement(19448..20098)
                     /locus_tag="ACL8AS_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000188500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="HGS1228982.1"
                     /translation="MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKR
                     MKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLE
                     HTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
                     SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNIDIAKQLYVEKIN"
     gene            20210..21052
                     /locus_tag="ACL8AS_001109"
     CDS             20210..21052
                     /locus_tag="ACL8AS_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HGS1228983.1"
                     /translation="MTKIALLSDIHGNTTALEAVLADARQLGVDEYWLLGDILMPGTG
                     RRRILDLLDQLPITARVLGNWEDSLWHGVRKELDSTRPSQRYLLRQCQYVLEEISLEE
                     IEVLHNQPLQIHRQFGDLTVGISHHLPDKNWGRELIHTGKQEEFDRLVTHPPCDIAVY
                     GHIHQQLLRYGTGGQLIVNPGSIGQPFFLDAQLRKDLRAQYMILEFDDKGLVDMDFRR
                     VDYDVAAELQLAKDLRLPYFEVYYESLVNGIHHTHHQEFLRELAQKEGCDRELDDWLK
                     SGND"
     gene            21128..21565
                     /locus_tag="ACL8AS_001110"
     CDS             21128..21565
                     /locus_tag="ACL8AS_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HGS1228984.1"
                     /translation="MQIPSRFTIATHMLIIIALEGKESKVTSDFLAASVGVNPVIIRK
                     ILSQLKKAELISVARGTGGTEIVKDLKDISLLDVYQAVECLGKTGQLFSFHDNPNPNC
                     PVGAHIHDVLDQKLERIQLTMEAELGQTSLEKVVADAESQMKD"
     gene            21633..21935
                     /locus_tag="ACL8AS_001111"
     CDS             21633..21935
                     /locus_tag="ACL8AS_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000281600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1228985.1"
                     /translation="MYLVIGIVLAFIVSFWKDNRSLWNPVLFLLSLISSYFYLSYLFY
                     KNGYENVQLAFYVFAFVLLPFLLFLSGIFLIYNGVILLKREGRSKPHYLSMLFDFY"
     gene            complement(22026..23099)
                     /locus_tag="ACL8AS_001112"
     CDS             complement(22026..23099)
                     /locus_tag="ACL8AS_001112"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2974 domain-containing protein"
                     /protein_id="HGS1228986.1"
                     /translation="MANIFDYLKDVAYDSYYDLPLNELDILTLIEITYLSFDNLVSTL
                     PQRLLDLAPQVPREPTMLTSKNRLQLLDELAQHKRFKNCKLSHFINDIDPELQKQFAA
                     MTYRVSLDTYLIVFRGTDDSIIGWKEDFHLTYMKEIPAQKHALRYLKNFFAHHPKQKV
                     ILAGHSKGGNLAIYAASQIEQSLQNQITAVYTFDAPGLHQELTQTAGYQRIMDRSKIF
                     IPQGSIIGMMLEIPAHQIIVQSTALGGIAQHDTFSWQIEDKHFVQLDKTNSDSRQVDT
                     TFKEWVATVPDEELQLYFDLFFGTILDAGISSINDLASLKALEYIHHLFVQAQSLTPE
                     ERETLGRLTQLLIDTRYHAWKNR"
     gene            23255..23932
                     /locus_tag="ACL8AS_001113"
     CDS             23255..23932
                     /locus_tag="ACL8AS_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HGS1228987.1"
                     /translation="MHKILLIEDDQVIRQQVGKMLSEWGFEVVLVEDFMEVLSLFVQS
                     EPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKP
                     FDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
                     RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGI
                     GYGLKHA"
     gene            23925..24899
                     /locus_tag="ACL8AS_001114"
     CDS             23925..24899
                     /locus_tag="ACL8AS_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HGS1228988.1"
                     /translation="MLDWKQFFLAYLRSRSRLFVYLLSLAFLVLLFQFLFASLGIYFL
                     YFFLLCCFVTILFFTWDILVEMQVYRQELLYGEREAKSPLEIALAEKLEAREMELYQQ
                     RSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNL
                     VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKW
                     LLVVIEQIISNSLKYTKEGGLEIYMDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGR
                     LTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVLE"
     gene            complement(24948..26891)
                     /gene="thrS"
                     /locus_tag="ACL8AS_001115"
     CDS             complement(24948..26891)
                     /gene="thrS"
                     /locus_tag="ACL8AS_001115"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004829 - threonine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006435 - threonyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HGS1228989.1"
                     /translation="MINITFPDGAIREFESGVTTFEIAQSISNSLAKKALAGKFNGKL
                     IDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGF
                     YYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIE
                     EHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIY
                     GTAWFDKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRE
                     LERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPM
                     NCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTP
                     EQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAA
                     LDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADG
                     EDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVA
                     KKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQ
                     TVSVDNFVQAILADIANKSRVEK"
     gene            complement(26949..27272)
                     /locus_tag="ACL8AS_001116"
                     /pseudo
     CDS             complement(26949..27272)
                     /locus_tag="ACL8AS_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000422771.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
     gene            complement(27529..27892)
                     /locus_tag="ACL8AS_001117"
                     /pseudo
     CDS             complement(27529..27892)
                     /locus_tag="ACL8AS_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397621.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            28130..28759
                     /locus_tag="ACL8AS_001118"
     CDS             28130..28759
                     /locus_tag="ACL8AS_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HGS1228990.1"
                     /translation="MKLAVIAANGQAGKAIVEEAVKRGHEVTAIVRSENKSQAESIIK
                     KDLFELTKDDLTGFDAVISAFGAYTPDTLPLHSKSIELFNQLLAGTQTRFLVVGGSGS
                     FYIDETKTTRLLDTSDFPEEFKPLAKAQADELDLLRTKNNLNWTFVSPAVDFIPDGEK
                     TGNYILAGEIFTTNEKGISQISYADYAIGLVDELEKGHHIKECISLLEK"
     gene            28900..29169
                     /gene="rpsO"
                     /locus_tag="ACL8AS_001119"
     CDS             28900..29169
                     /gene="rpsO"
                     /locus_tag="ACL8AS_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HGS1228991.1"
                     /translation="MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIK
                     QHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR"
     gene            29985..30599
                     /locus_tag="ACL8AS_001120"
     CDS             29985..30599
                     /locus_tag="ACL8AS_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000531723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="HGS1228992.1"
                     /translation="MGQTIISAIGVYISTSIDYLIILIILFAQLSQNKQKWHIYAGQY
                     LGTGLLVGASLVAAYVVNFVPEEWMVGLLGLIPIYLGIRFAIVGEDAEEEEEEIIERL
                     EQSKANQLFWTVTLLTIASGGDNLGIYIPYFASLDWSQTLVALLVFVIGIIIFCEISR
                     VLSSIPLIFETIEKYERIIVPLVFILLGLYIMYENGTIETFLIV"
     gene            complement(30892..31641)
                     /locus_tag="ACL8AS_001121"
     CDS             complement(30892..31641)
                     /locus_tag="ACL8AS_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="HGS1228993.1"
                     /translation="MFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRT
                     WWDPVYMAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINV
                     LKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMTLKGLISRERVDM
                     NFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWWFIRIPAL
                     ILAIILAILTIIFSFIASFIWNPDKKREELA"
     gene            31774..34110
                     /locus_tag="ACL8AS_001122"
     CDS             31774..34110
                     /locus_tag="ACL8AS_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HGS1228994.1"
                     /translation="MDKNKIMGLTQREVKERQAEGLVNDFTASASTSTWQIVKRNVFT
                     LFNALNFAIALALAFVQAWSNLVFFAVICFNAFSGIVTELRAKHMVDKLNLMTKEKVK
                     TIRDGQEVALNPEELVLGDVIRLSAGEQIPSDALVLEGFAEVNEAMLTGESDLVQKEV
                     DGLLLSGSFLASGSVLSQVHHVGADNYAAKLMLEAKTVKPINSRIMKSLDKLAGFTGK
                     IIIPFGLALLLEALLLKGLPLKSSVVNSSTALLGMLPKGIALLTITSLLTAVIKLGLK
                     KVLVQEMYSVETLARVDMLCLDKTGTITQGKMQVEAVLPLTETYGEEAIASILTSYMA
                     HSEDKNPTAQAIRQRFVGDVAYPMISNLPFSSDRKWGAMELEGLGTVFLGAPEMLLDS
                     EVPEAREALERGSRVLVLALSQEKLDHHKPQKPSDIQALALLEILDPIREGAAETLDY
                     LRSQEVGLKIISGDNPVTVSSIAQKAGFADYHSYVDCSKITDEELMAMAEETAIFGRV
                     SPHQKKLIIQTLKKAGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLLN
                     SDFNDVPEILFEGRRVVNNIAHIAPIFLIKTIYSFLLAVICIASALLGRSEWILIFPF
                     IPIQITMIDQFVEGFPPFVLTFERNIKPVEPNFLRKSMLRALPSALMVVFSVLFVKIF
                     GSSQGWSELEISTLLYYLLGSIGFLSVFRACMPFTLWRVLLIVWSVGGFLATALFPRI
                     QKLLEISTLTGQTLPVYGVMMLVFTVIFILTSRYQARK"
     gene            34212..34889
                     /locus_tag="ACL8AS_001123"
     CDS             34212..34889
                     /locus_tag="ACL8AS_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenine(22)-N(1))-methyltransferase TrmK"
                     /protein_id="HGS1228995.1"
                     /translation="MISKRLELVASFVSQGAILLDVGSDHAYLPIELVERGQIKSAIA
                     GEVVEGPYQSAVKNVEAHGLKEKIQVRLANGLAAFEETDQVSVITIAGMGGRLIARIL
                     EEGLGKLANVERLILQPNNREDDLRIWLQDHGFQIVAESILEEAGKFYEILVVEAGQM
                     KLSASDVRFGPFLSKEVSPVFVQKWQKEAEKLEFALGQIPEKNLEERQVLVDKIQAIK
                     EVLHVSK"
     gene            34876..35673
                     /locus_tag="ACL8AS_001124"
     CDS             34876..35673
                     /locus_tag="ACL8AS_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000881127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051540 - metal cluster binding [Evidence
                     IEA];
                     GO_process: GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HGS1228996.1"
                     /translation="MLASEVIQAYEAFCPQEFSMEGDSCGLQIGTLDKGIQRVMVALD
                     IREETVAEAIEKGVDLIIVKHAPIFRPIKDLLASRPQNQIYIDLIKHDIAVYVSHTNI
                     DIVENGLNDWFCQMLGIEETTYLQETGPERGIGRIGNIQPQTFWELAQQVKQVFDLDS
                     LRMVHYQENDLQKPISRVAICGGSGQSFYKDALAKGADVYITGDIYYHTAQDMLSDGL
                     LALDPGHYIEVLFVEKIATLLTQWKEKKGWELEILPSQASTNPFRHI"
     gene            35690..36793
                     /locus_tag="ACL8AS_001125"
     CDS             35690..36793
                     /locus_tag="ACL8AS_001125"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HGS1228997.1"
                     /translation="MKKVAIIGAGIVGATAAYYLSRESDLEVTVFDHEQGQATKAAAG
                     IISPWFSKRRNKAWYKMARLGADFYVDLLADLEKSGQKIDFYQRSGVFLLKKDESKLE
                     ELYQLALQRREESPLIGQLAILDQASANELFPGLQGFDRLLYASGGARVDGQLLVTRL
                     LEASHVKLVKEKVTLTLLSSGYQIGEEVFDQVILATGAWLGDMLEPLGYEVDVRPQKG
                     QLRDYQLAQDMEDYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDEPLLQQME
                     EAALPHYPVLARATSRAERVGIRAYTSDFSPFFGQVPELAGVYVASGLGSSGLTTGPI
                     IGYHLAQLIQDKELTLDPLNYPIENYVKRVKSE"
BASE COUNT        10726 a         6934 c         8479 g        10713 t
ORIGIN      
        1 aaatttttat tttataatat cagaaaatac tttttttaaa aagcaaatat gatacaattt
       61 tatttgaaaa aaataaaaaa ggagatttta ttatgaaatc aagtggtatc gtcggtcttg
      121 tgggaggaat tttacttctt atttgtcctt ttgtcttgtt gggaacagcg gtaaatacag
      181 ctgctacaac tcttaatgga ggagctactg caggggcttt ttcaggtgtt gccttactct
      241 tgaatgcctt gaagattgca aatcttgttc ttggtatcat tgctattgtt tactataaag
      301 gagataagcg tgtaggtgca gctccgtctg tactaatgat tgtttctggt gaagttagtc
      361 tcattccatt cttaggatgg gttgggggga ttcttgctat tatcggagga tctctattcc
      421 ttgcaacatt gaagaaattc aaatcagaag aataaaaggt attttagcat gaaaagaaca
      481 aaaaagttta tcggtatagg agtagctcta ttatctcttt ctcttctagt tgcatgtgga
      541 acataaagtt caaagaatac ttcaacaagt aatgatgaga agacagtagc aacatccaat
      601 agttcaaaag aaacaatcac ttttgataca ccggttgtaa cagacgatgc gattgaatca
      661 atacgcactt atgcagatta tatagatctt tataaaaata tttttgatga ttattttact
      721 aaaactgagg aaggtttcaa aggcacagct atggaaaata atgactcgtt tactaaacta
      781 aaagagtcaa ctcaaaaatt attcgatgcg cagaaaaaaa ggttaaataa tgaagataga
      841 atagaaacaa caaaaaacaa tgtgattgcc aaacattgtc aaacagtcct ttcctttttg
      901 gttttgacta gcttttttgt gaaaaattgt gtaaaataga atagataaac gaggggaaac
      961 ctcggaaaat ttaaaggaga atccatctaa tggtaaaatt ggtttttgct cgccacggtg
     1021 agtctgaatg gaacaaagct aaccttttca ctggttgggc tgatgttgat ttgtctgaaa
     1081 aaggtacaca acaagcgatt gacgctggta aattgatcaa agaagctggt atcaaatttg
     1141 accaagctta cacttcagta ttgaaacgtg ctatcaaaac aactaacttg gctcttgaag
     1201 cttctgacca attgtgggtt ccagttgaaa aatcatggcg cttgaacgaa cgtcactacg
     1261 gtggtttgac tggtaaaaat aaagctgaag ctgctgaaca atttggtgat gagcaagttc
     1321 acatctggcg tcgttcatac gatgtattgc ctccaaacat ggaccgtgat gatgagcact
     1381 cagctcacac agaccgtcgt tacgcttcac ttgacgactc agttatccca gatgctgaaa
     1441 acttgaaagt gactttggaa cgtgctcttc cattctggga agataaaatc gctccagctc
     1501 ttaaagatgg taaaaacgta ttcgtaggag ctcacggtaa ctcaatccgt gcccttgtaa
     1561 aacacatcaa aggtttgtca gatgatgaga tcatggacgt ggaaatccct aacttcccac
     1621 cattggtatt cgaattcgac gaaaaattga acgttgtttc tgaatactac cttggaaaat
     1681 aaaaaattgt aagcctagga ttgatttcta ggctttttat gttagtatgg aagtatgata
     1741 aggaataaaa aacaagatta tgtactggcc tacaaacaac cagcttcaac cacttacatg
     1801 ggttgggaag aagaagcttt accgataggt aatggttctt taggagcaaa agtatttggc
     1861 cgtatagggg ctgaacggat tcaatttaat gaaaaaagtc tctggtctgg aggtccactt
     1921 cctgatagtt cagattatca gggtggaaat cttcaggatc agtatgtttt tttagctgag
     1981 attcggcagg ctttggagaa gagagattac aatctggcta aggaactggc tgagcagcac
     2041 ctaattgggc caaaaacgag tcaatatggg acctatctgt cttttgggga tattcacatt
     2101 gagttcagcc agcaaggtac gactttgtct caggtgacgg actatcagag acagctgaat
     2161 attagtaagg cacttgcgac gacttcttat gtctataagg gaacgcgatt tgaacgtaaa
     2221 gcttttgcga gttttccaga tgatctcttg gttcaatgtt ttactaagga agggttggaa
     2281 actctagatt ttactataga actatccttg acctgtgatt tggcttctga tggaaagtat
     2341 gagcaggaaa aatctgatta caaggagtgt aagttggata ttactgattc tcatatcttg
     2401 atgaagggaa gagttaagga taatgatctg cggtttgcta gttatctagc ttgggaaacg
     2461 gatggagata ttagagtttg gtcagatagg gttcagatat caggagccag ttatgccaat
     2521 ctcttcttgg ccgctaagac ggattttgcc caaaatcctg ctagcaatta tcgcaagaaa
     2581 ctagatttag agcaacaggt gatagacttg gtggacacag ctaaagaaaa gggctatacc
     2641 caattgaaat caaggcatat cgaggactac caagccttat tccagcgtgt tcaattggat
     2701 ttggaagctg atgttgacgc atccactaca gatgatttgt taaaaaatta taagccacaa
     2761 gaagggcagg ctttggagga gctgttcttc cagtatggac ggtatttatt gattagttcg
     2821 tccagagact gcccagatgc tctaccagct aacctacagg gagtctggaa tgcggtcgac
     2881 aatcctcctt ggaattcgga ctatcactta aatgtcaatc tgcagatgaa ttattggcca
     2941 gcctatgtta ccaatctcct agagacggtc tttccagtca tcaactatgt agatgatttg
     3001 cgtgtctatg gtcgtctagc ggctgtaaag tatgcaggaa tcgtctctca gaaaggtgag
     3061 gagaatggtt ggttggttca tactcaagcg actccctttg gttggacggc acctggttgg
     3121 gattactatt ggggttggtc accagctgcc aatgcgtgga tgatgcaaac cgtttatgaa
     3181 gcctattcat tttataggga ccaagactat ctcagggaga aaatttatcc catgttgagg
     3241 gaaacggttc gtttttggaa tgccttttta cataaggatc agcaggcgca gcgttgggtg
     3301 tcttctccgt cttattcccc agaacatggg ccgatttcga ttggcaatac ctatgaccaa
     3361 tctctgattt ggcagttatt tcatgatttt attcaggctg ctcaggaatt gggactggat
     3421 gaggacttgt tgactgaggt taaggagaag tctgatttac taaatccttt gcaaatcact
     3481 caatctggtc gaatcaggga gtggtatgag gaggaagagc agtattttca aaatgagaaa
     3541 gtggaggccc agcatcggca cgcttcccat ctagtgggac tctatcctgg caatctcttt
     3601 agctacaagg gacaagagta tattgaagcg gcgcgtgcta gcctcaatga tcgtggagat
     3661 ggcggcacag gctggtccga ggctaataag atcaatctct gggcgcgttt gggagatggc
     3721 aatcgagccc ataaattatt ggcagagcag ttaaagacat ccaccttgca aaatctttgg
     3781 tgtagccatc ctccttttca gatagatggt aattttggtg ctactagtgg catggcagaa
     3841 atgttactcc agtctcatgc agcttatctg gtacctctag ctgccctacc tgatgcttgg
     3901 tcaacaggtt ctgtttcagg cttaatggca cgtggacatt ttgaagtgag catgagctgg
     3961 gaagataaaa aactcttaca gttgaccatt ttatcaagga gtggaggaga tttgcgagtt
     4021 tcttatccag atattgagaa gagtgtgatt aaaatgaatc aagaaaaaat aaaagcgaaa
     4081 tgcatgggga aagattgtat ttcggtggca acagcagaag gtgatcttgt tcaattttat
     4141 ttttaagaag atgttataag gcagtaattt gaaactgcct tttaataagg atttaagaat
     4201 ataagcagtt ttcaactagt tgaaaaagcg ttataatgat aataggaagt aatactcaat
     4261 gaaaatcaaa gagcacaaac aaggaagcta gccgcaggtt gctcaaaaca gtgttttgag
     4321 gttgcagatg gaagctgacg tggtttgaag agagattttc gaggagtata atttgtttga
     4381 tagagggtgg gtctgatggc ttatattgag atgaaacact gttacaagcg ttatcaggtt
     4441 ggggacacgg agattgtggc caatcgtgat gtgaattttg agattgaaaa gggggagctg
     4501 gttattatcc ttggtgcttc aggtgcaggc aagtcaacag tgcttaacct tcttggggga
     4561 atggatacca atgatgaagg ggaaatctgg attgatggtg ttaatattgc ggattatagt
     4621 tcccaccagc gcaccaatta ccgtagaaat gatgtggggt ttgtttttca gttttataat
     4681 ctagtttcta atctgacagc taaggaaaat gtggaactgg cttctgaaat tgtgacagat
     4741 gccttgaatc ctgatcaggt cttgacagat gtaggtctgg ctcatcgtct aaataacttt
     4801 ccagcccagc tttctggagg ggagcaacag cgagtctcca ttgcacgcgc ggtagccaaa
     4861 aatcctaaaa ttctcctttg tgatgaaccg actggagcct tggattatca gacgggcaag
     4921 caggttttga aaattctcca agacatgtct cgtcaaaagg gagcgacggt gatcatcgtg
     4981 actcataatg gagctttggc gcccattgct gatcgcgtga ttcatatgca cgatgccagt
     5041 gtcaaggatg tggtgctcaa ccagcatcct caggatattg acagtttgga gtactagcat
     5101 gatcaagcga aaaacttatt ggaaggactt aattcagtcc ttcacaggct ccaaggggcg
     5161 ttttttatcc atcttgatcc tgatgatgtt gggatctcta gccttagtag gcctcaaagt
     5221 aaccagtccc aacatggagg cgacagctaa tgcttattta acaactgctc aaaccttgga
     5281 tttggcagtc atgtctaact atggcttgga tcaagcagac caagaagaac taaaacagac
     5341 ggagggcgca gaggtcgagt ttggctattt gacagatgtg actatggata atgggcagga
     5401 tgccattcga ctgtactcca aaccagagcg aatttcaacc tttcagctaa ggaagggacg
     5461 acttcctcag tcagacaagg aaatcgcttt ggccactcat ttgcaaggcc aatacagcgt
     5521 gggacaggag attagtttta aagaaaaaga agagggtcat tcctctttaa aagaccatac
     5581 ttataccatt actggttttg tggattcggc tgaaatcctc tcccagcgag atatgggcta
     5641 cgcaggaagt ggaagtggga ctctgacagc ctatggggtg attttaccta gtcagtttga
     5701 tcagaaagtc tacaatatag ctcgtttgaa atatcaagat ttagcaggtt taaatgcctt
     5761 ttcatcagct tatgaagaaa aatccaagca acatcaggaa gagcttgaac aaattttatc
     5821 agataatggc aaggtacgtc tgcaactttt gaaaaaagaa ggacaagagt ctctagacaa
     5881 ggggcaagag acccttgaca aggctcagac taatttgcag gaaggcaagc gtcgtttagc
     5941 agctgctcaa gctcgtatac aggctcaaga aagtcaacta gccttgtttc ctcaagttca
     6001 gagagagcag gctagtgctc aacttaccca agccaagcag gaattgggca aggaagaggc
     6061 caaactaaag caagctgaac aaaatctagc ccaagaaaag gaaaaattag aaaaacatca
     6121 gcaagtcttg gacgatttgg cggagccaag gtatcaggtc tataatcgtc agaccatgcc
     6181 aggtggtcag ggctatctta tgtatagcaa tgcttcatcc agtattcgag cagtgggcaa
     6241 tatctttcct gtggtacttt atgccgtagc agccatggtg acctttacga ccatgactcg
     6301 ctttgtagac gaagagcgaa ctcatgcagg gatttttaag gccttgggtt accgtagtaa
     6361 ggatattatc accaagtttc tcctttatgg actagtagct gggactgtcg gaacggctct
     6421 aggtagtata cttggtcatt atttgctagc cagtgtaatt tcaagtgtca ttacaaaagg
     6481 catggtggtg ggagaaaccc agattcagtt ctattggacc tatagcttac tagctcttgt
     6541 cttgagcttg ttggcgagtg tgttaccagc ctatctggtg gcttggaggg aacttcatgc
     6601 cgaagcagcc cagcttctac ttcctaaacc tcctgtcaaa ggagctaaaa tcttattgga
     6661 gcgtatcggt tttatctggc gtcgtctcag ttttactcat aaggtaacag cccgcaacat
     6721 ctttcgttat aagcagagaa tgttgatgac aatctttggt gtggcaggtt ctgtagctct
     6781 gctctttgca ggtttgggaa tccaatcttc tgtagcagga gttccgtcta aacagtttca
     6841 acaaatccaa cagtatcaga tgcttgtctc tgaaaatcct agtgcgacca atcaggacaa
     6901 ggtagagcta gcagaagtat tgaaagggca ggagatacta gcctaccaga aaatctattc
     6961 taaaacgcta gacaaggatt tcaaaggcaa ggctggtctt caaaacatta ctcttatgat
     7021 gatagagaag gaagatttga ctccctttat ccatcttcaa catcatcagc aggagctgac
     7081 attaaaagat ggcatcgtta ttacagctaa actcgcccag ctggcaggtg tcaaggttgg
     7141 gcagacttta gaaattgaag gtaaggaact aaaggtcgct gctattactg agaactacgt
     7201 tggtcacttt atttatatga gtcaggctag ctatgagcaa ctttacggac agctacccca
     7261 agccaacact tatctggtct cattaaggga taccagtgca actagtatcg aaagtcaggc
     7321 gggcttgctt atgaatcaat ctgcggtgtc cagcgttgtc caaaatgctt cagccattcg
     7381 actcttcgac tctatcgcta gctcactcaa tcagaccatg accatcttgg tcatcgtatc
     7441 ggttctatta gctattgtca tcctttacaa tctgaccaat atcaacgtag ctgagagaat
     7501 ccgtgaactc tccactatca aggttctcgg ttttcataat aatgaagtca ccctctacat
     7561 ttaccgtgag acgattgtgc tgtcccttgt gggaatcgta cttggtctgg tagctggttt
     7621 ctatttacac caatttttga ttcaaatgat ttcgcctgcg actattctct tttatccgca
     7681 ggtaggctgg gaagtctatg taatcccagt ggcagcagta agcatcattt tgaccttgct
     7741 tggtttcttc gtcaattatt atctgagaaa ggttgacatg ttagaagccc tgaaatctgt
     7801 agagtaaggt agttattttt agctgattga acttctattt actaatattc aaaaatcctc
     7861 cgtttcaaag agcagggaac tctttgtgac agaggatttt ttctataggg ctttagcagc
     7921 tgcaattgcg gcttcgaagt ttggctcaga attgatatta tccacgtatt caacgtagcg
     7981 aatcgtattg tcagtatcga ggacaaagac tgcgcgtgct aatagatgcc attcgttgat
     8041 caagagggca taatcgcgcc cgaaagaatg gtcaaagtag tctgaaagca taatggcatt
     8101 gtcaaggcct tcagcaccgc accaacgttt ttgagcaaaa ggtaggtcca ttgaaacagt
     8161 caatacgacc gtgttgtcca gtccagctaa ttcttcatta aaacgacgtg tttgagttga
     8221 gcagatgcct gtatcgatag aaggaacgac actcaagact tttttcttgc catcaaaatc
     8281 agccagagat tttttagaaa gatctgttgt agtaagagaa aaatcaagcg ccttgtcgcc
     8341 gacttgtagt tgtttacctg taaagctcac aggatttccg agaaaagtta ccataggata
     8401 ctccaatctt ttttcttcca ttgtatctga aacagtcaga attttccaat gatttgaccg
     8461 gaaatgtggg catagaaaaa acgccagctc acatgagaat gacgtttttc agaggcttat
     8521 tttgccaatc cttcagcaat cttgtcaagg ttgtatttca tcatgctgta gtagctgtcg
     8581 ccttctttac cttgttctgc gatagagtca gtaaagattt gtgcgtagat tgggatgttt
     8641 gtgtcttgag aaacagtttt cattggacgg tcatccacac ttgattctac aaagagtgat
     8701 ggaacttttg tttggcgaag tttttcaacc aaggtcttga tttgttcagg agttccttct
     8761 tcttcagtat tgatttccca gatgtaggca cttggaacac cataggcttt agagaagtat
     8821 ttgaatgctc cttcgctggt tacaatgagt ttcttttcag cagggatctt attaaattta
     8881 tccttacttt ctttatcaag tttgtctaac ttatcagtat attctttgag atttttttca
     8941 tagaattctt tattgttagg gtctttggcg ctcaattgtt tggcgatatt tttagcaaaa
     9001 ataataccgt tttcaaggtt aagccaagcg tgtgggtctt cttttccttt ttcattttga
     9061 ccttcaaggt agataacatc aacgccgtcg ctgactgcga agtagtcttt gttttcagtt
     9121 ttcttggcat tttctaccaa ttttgtaaac caagcattgc cacctgtttc aaggttgata
     9181 ccgttataga aaatcaaatc agcctcagaa gttttcttaa cgtcttcagg aagtggttcg
     9241 tattcgtgtg ggtcttgccc aatcggaacg atactatgaa ggtcaatttt gtcaccagca
     9301 atatttttag taatatcagc gatgattgag tttgtagcaa caacttttag tttttgacca
     9361 gaagttgtat ctttttttcc gctagcacat gctacaagaa tgattgcaga aagaaagaga
     9421 acgagtaatg tacctaattt tttcattaga tcctccaatt tattagggct ttgcccctta
     9481 ttttaacaaa tgtttatttt tcagtttcaa atatcgttgt ttgggagcga taaagaagct
     9541 aatgagaaag aaactagcag ctgtaagcac gatactagaa cctgccgcaa cattaaaact
     9601 atagccaata aagagtccca aaactgaagc agtagctccg aaggttgagg aaaggaaaat
     9661 catgcttttc agactattag catacagata agcagttgca gctggggtaa tcagcatggc
     9721 tacaatcagg atagttccga cactttgcat ggctgtcaca gacacgagag tcaggagtac
     9781 catgagaagg tagtgataga aattgacagg cattcccatg gctttagcca agagttcatc
     9841 aaaggaagtt atcaagagtt gcttgaagaa aatccagatt aacaagagga tggctgcccc
     9901 cacacccata gtaataaaca tatccgtatc ttggacggcc aggatattac caaaaaggat
     9961 atggaaaagg tcagttgaac ttttagcgac accaatcaag atgataccga gggctaagaa
    10021 agaagaaaag gtaatgccga tggcggtatc gcttttgata atcgagtttc ctttgatgta
    10081 ggtaatgatg atggcagcta gcaatccaaa gacaatggct ccgataaaga agtcaaggcc
    10141 caagatgaag gagagggcta cacctggtaa gacagcatgt gaaatggcat ctcccatgag
    10201 tgacatcccg cgtagaataa tgaaacatcc cacagctcca gctacaatcc cgacgacaat
    10261 agctgttatc aaggcatttt gtaggaaatg gaatttttgc aatccatcga taaattctgc
    10321 aatcataggt cacctccatt gaaaaagagt tgattaccgt aagcttcttt tagattggtt
    10381 tcggtaaaag tttcttttgt tggaccaaag gcaatcactt ctcgattgac aagtaagact
    10441 tgatcgaagt agtggggaat cttgctgagg tcgtggtgaa cgatgagaac cgtcttccca
    10501 gcttttttca aatctctcag cgtattcatg atgatttcct cactgacaga gtcaatccca
    10561 gcaaagggtt catccaagag gatatagtcg gcttcctgca ccaaacatct ggcaatcaag
    10621 acccgctgga attgacctcc agacagttga ctaatttgac gttcagcgta gtcagctagg
    10681 ccgacgattt caagggcctc ttgcactttc ttccaatgtt tagcctttaa acttcgaaag
    10741 agaggaatag agggaaatag tcctaacgag acgcattcct tgaccttgat gggaaagttg
    10801 tagtcgatat tgattttttg ttcgacatag gcaattcggt gtaaggattt tttaacttcc
    10861 ttgtcatcga gaaatgcctg accttgatgt gggataattc ccagcatacc ttttaatagt
    10921 gttgatttcc cagcgccgtt tggaccaatg atgccggtaa ttgttggtcc atggagcact
    10981 agtgaaatat ccttaagtgc caacgtttct ttgtaggaga cactgaggtt ttcgatacgt
    11041 atcataaact tgtattcctc ctgtctctta atatacatta aaaaaaaaat taagtcaagt
    11101 taatttttga aaaaattaaa ataataactg aaaaatagat tctaaagata actttttatc
    11161 atgcaaaggt tttttataat agctaaaaaa taatagttaa atggttgtta attgcattcc
    11221 ctagtgattt ttgttaagat aaaggcaaat acaaatgaaa gcgagaacaa gatgacacgt
    11281 tatcaagatg atttttatga tgctatcaat ggagaatggc aacagacagc tgaaatccca
    11341 gcagataagt ctcaaacagg aggttttgtt gatttagacc aggaaattga agacctgatg
    11401 ctggcgacaa cagacaagtg gttagcaggt gaagaagtgc ctgaggatgc tatcttggaa
    11461 aactttgtca aataccaccg cctagttcgt gattttgaca agagagaagc tgacggtatc
    11521 acacctgtct taccactcct taaagaattc caagaattgg agacttttgc ggattttaca
    11581 gctaaactag cagagtttga gcttgcagga aaaccaaact tccttccttt tggtgtatcg
    11641 ccagacttta tggatgctag aatcaatgtt ctatgggcta gcgctccaag cacaatcttg
    11701 ccagatacga cctactatgc agaagaacat cctcagcgcg aagagctctt gactctttgg
    11761 aaagaaagca gcgcaaatct cctcaaggct tatgatttct ctgatgaaga aattgaagac
    11821 ttgctagaaa aaagacttga attggaccgc cgagttgcgg cagtggtgct ctctaatgaa
    11881 gaaagttcag aatatgctaa actctatcat ccatattctt acgaagattt caagaaattc
    11941 gcgcctgccc tacctttgga tgacttcttc aaagcagtta ttgggcaatt accagacaag
    12001 gttattgtag acgaggaacg tttctggcaa gcagcagagc aattctacag tgaggaagcc
    12061 tggtctctcc ttaaagcaac cttgattttg agtgttgtca atctttcaac cagctattta
    12121 acagaggata tccgtgtttt gtctggtgcc tacagccgtg ccctttctgg agttccagag
    12181 gcaaaagata aggccaaagc agcttatcat ctagcacaag aacctttcaa gcaagccctg
    12241 ggtctttggt acgcccgtga gaagttctct ccagaagcca aggcggatgt ggagaaaaaa
    12301 gtggcaacca tgattgatgt ctataaggag cgtctgctta agaatgactg gctcactcca
    12361 gaaacctgta aacaggctat cgtgaagctc aatgtgatca aaccttatat tggctatcca
    12421 gaagaattgc ctgcacgtta caaggataag gtagtgaatg aaactgccag tctttttgag
    12481 aatgctctag cctttgcgcg tgtggaaatc aagcacagtt ggagtaagtg gaaccagcct
    12541 gtagactata aggaatgggg catgcctgct catatggtca atgcctacta caatcctcag
    12601 aagaacctga ttgtctttcc agcggccatt ttacaggcgc ctttctatga cttgcatcag
    12661 tcatcttctg ctaactacgg tggtattggg gcagtgattg cccatgaaat ttcccacgcc
    12721 tttgatacta acggggcttc ctttgacgaa aatggtagcc tcaaggattg gtggacagag
    12781 agcgactatg ctgccttcaa ggagaaaaca caaaaagtca ttgaccaatt tgatggacag
    12841 gattcttatg gagcaaccat taacggtaaa ttgactgtat cagaaaacgt ggctgacttg
    12901 ggaggaatcg cagcagcgct tgaagcagct aagagagaag cagacttctc agcagaagag
    12961 ttcttctaca acttcggtcg catctggcgc atgaaaggtc gaccagaatt tatgaaactt
    13021 ttggctagcg tcgatgtgca cgcaccagcc aaactccgtg tcaatgtgca agtaccaaac
    13081 ttcgacgatt tctttacaac ctatgatgtc aaagaaggag acggaatgtg gcgttcacca
    13141 gaggagcgcg tgattatttg gtaatgcaaa aaatctagtc atcagaaaaa aggcatccaa
    13201 tcacgtgtga aaaccttgat aggatgcctt ttataataga aagatttgct ggatagttta
    13261 cttaaatttc gattgtcatc atcttgctaa aaaaagggat tgaaggcctt ttcgtgagcg
    13321 atagtagtag ctggaccatg tcctggatag acatcgtagt ttggtagggt gaagagttgg
    13381 gtctggatac tatgaaggag ttgctccatg ctaccagtcg gaaggtcggt ccgtccgata
    13441 gtttcgcgga atagagcatc tcccgtcaag actaggtgag catcaggaaa gactagggaa
    13501 acaccaccga tagagtgccc tggggtcggt agaaccttaa aacgaaattc ctctagttgg
    13561 tattcttcgt gaaagacaaa ggtgtgttct gcaggttttg tgaccacatc tgccatatca
    13621 tcgtggcgag ggagaccgga gagattatcg acaggagtgt agagccagct ggcttcgctc
    13681 tctgcgatat agacaggagg attgccaaac gtctcgcgaa ccaagtccag actcatgata
    13741 tggtcataat gggtgtgggt caagagaata gcacagatcg gtttgttgat cttctcgatt
    13801 gtctgacgaa tggcttccca atgactacca ggatcgacga cgatgaggtg cttttcgcct
    13861 tctagataat aggtattttc ataggcaaca ggattcacgg ttttatggat tttcatacta
    13921 gctccaatct caaagaatgt actaatactc ttcgaaaatc tcttcaaacc gcgtcaactt
    13981 tatctgcaac ctcaaagcag tgctttgaac agcctgcggc tagctttcta gtttgctctt
    14041 tgattttcat tgagtataaa ttaagtatag cacagttagg gagaataggt aaggatttaa
    14101 aatgaactta aaaaccagca tgactagatg aagacaggct ggttatcaat ttatcaatat
    14161 tggaaaggtg tcaattgccc ttcataggtt gcataaactc cgtcattagc ttgtttgata
    14221 gacgtgatgt ttagagtgct accgtagttg gcttctcatt tgtcgctata ttcactataa
    14281 gttatcctac tgggcaggtt ctggtcgtta gcatagtatt gaacgagttt tttatagctt
    14341 tgctggctga ataggaacag gcagcaaact cctaacatta ggagagcaaa gatagaaata
    14401 gcagtttttt tcataggtat tctccttata aactaaagga tagaagaaag tatcttgagg
    14461 atttttatac tcttcaaaaa tctcttcaaa ccgcgtcaac gtcgccttgc cgtatatatg
    14521 tgactgactt tgtcagtctt atctacaacc tcaaagcagt gctttgagca acctgcggct
    14581 agtttcctag tttgctcttt gattttcatt gagtattaat tccaaaatcc agtcaaggta
    14641 ccagtgtatg tgatacgagt tccaccgttt atctttcgta tcttcaatgg aattggggaa
    14701 atcagaaagt ctttgggtta caatatggtt tccgttcttc tatctctcct tctatcacct
    14761 aagtttaaaa tctaacttcg tagtatatta tgggccaata attcagaatt atcaagcaat
    14821 tttgaattat ttttttctta ttctgttcca atctagtttt catattctta aaaaagtgat
    14881 aaaatggtag gaagaattgg agagtagaga tgccgaaaga agtgaattta acaggcgaag
    14941 aagttgtcgc tttaaccaaa gaatatttaa cggaagagga tgttcatttt gtccataagg
    15001 ccttggtcta tgctgttgaa tgccacagtg gtcaatatcg caaatcaggc gagccttata
    15061 tcattcaccc tatccaagtg gcaggtattt tagctaagct aaagctggat gctgtaacag
    15121 tagcttgtgg attcttgcat gatgtggtgg aagatacaga tgcgaccttg gacgatttgg
    15181 aaagagagtt tggtcctgat gtgcgggtga ttgttgacgg agttaccaag cttggcaagg
    15241 tcgagtacaa atcgatcgag gagcaattag cggaaaatca tcgcaagatg ctcatggcca
    15301 tgtctgagga catccgcgtt attttggtca aactgtctga ccgcttgcac aatatgcgga
    15361 ccctgaaaca tcttcgaaaa gacaagcagg agcgtatttc caaagaaacc atggaaatct
    15421 atgccccact tgcccatcgt ttggggattt ccagtgtcaa atgggaatta gaagacttgt
    15481 ctttccgtta tctcaatcca acggagtttt acaagattac ccatatgatg aaggaaaagc
    15541 gcagggagcg tgaggccttg gtggatgagg tagtcacaaa attagaggag tatacgacag
    15601 aacgtcactt gaaagggaag atttatggtc gtcccaagca tatttactca attttccgca
    15661 aaatgcagga caagagaaaa cggtttgagg aaatctatga tctgattgct attcgttgta
    15721 ttttagatac ccaaagtgat gtttatgcca tgcttggtta cgtgcatgaa ttttggaaac
    15781 cgatgccagg tcgcttcaaa gactatattg ccaaccgcaa ggctaatggt tatcagtcta
    15841 tccatacgac tgtttatgga ccaaaagggc cgattgaatt ccagattcga accaaggaaa
    15901 tgcacgaggt ggctgagtac ggggttgcgg ctcactgggc ttataagaaa ggtataaagg
    15961 ggcaagttaa cagcaaggaa tcagctattg gaatgaactg gatcaaggag atgatggagc
    16021 tccaagacca ggctgatgat gctaaggaat ttgtggactc tgttaaggaa aactatctgg
    16081 ctgaggagat ttacgttttt accccagatg gagctgtccg ttctcttccc aaagattcag
    16141 gaccgattga ttttgcctac gaaatccata ccaaggtcgg tgaaaaagca actggtgcca
    16201 aggtcaatgg ccgcatggtt ccactgacaa ccaagttaaa gacaggggat caggttgaaa
    16261 ttatcgccaa cccgaactcc tttggaccta gccgtgactg gctcaatatg gtcaagacta
    16321 gcaaggcgcg caataagatt cgccagttct ttaaaaacca agataaggaa ttgtctgtca
    16381 acaagggtcg tgagatgctg atggctcagt tccaagaaaa tggctatgtg gcaaataaat
    16441 ttatggacaa gcgccacatg gatcaagttc tgcaaaagac cagttacaag acagaagact
    16501 ccctctttgc ggccattggt tttggggaaa tcggtgcgat taccgtcttt aaccgtctga
    16561 ctgaaaagga gcgccgtgag gaagagcgtg ccaaggccaa ggctgaggca gaggagcttg
    16621 tcaaaggtgg cgaggtcaag gttgaaaata aagaaactct caaggtcaag catgaggggg
    16681 gagtggttat tgaaggtgct tctggtctcc tagtgcggat tgctaagtgt tgtaaccccg
    16741 tacctggtga cgatattgtt ggctacatta ccaagggtcg tggtgtggct attcaccgtg
    16801 tggactgtat gaacctgcgt gcccaagaaa actacgagca acgtctcctt gatgtggaat
    16861 gggaagacca gtactctagc tcaaataagg agtatatggc ccatatcgat atctacggtc
    16921 tcaaccgtac aggactgttg aacgatgtac tgcaagttct ttcaaataca accaagaata
    16981 tttcaacggt caatgcccaa ccaaccaagg atatgaagtt tgctaatatc catgtgtcct
    17041 tcggtattgc caacctctct acactgacca cggttgtcga taaaattaag agtgtgccag
    17101 aagtttactc tgtcaaacgg accaacggct agttgtccta gctcttacta gaaaggctat
    17161 tatgaaaatc attatccaac gggttaaaaa agcccaagtg agtatagaag gccagattca
    17221 gggaaaaatc aatcagggac ttttattgct ggttggtgtt ggaccagagg accaagagga
    17281 agatttggac tatgctgtga gaaaactggt caatatgcgg attttttcag acgcagaagg
    17341 caagatgaac ctgtctgtca aagatattga aggagaaatc ctctctattt ctcagtttac
    17401 cctctttgcg gatactaaga aaggcaatcg tccagccttt acaggggcag ctaaacctga
    17461 tatggcatca gacttctatg atgctttcaa tcaaaaatta gcgcaagaag tgcccgttca
    17521 gacaggtatc tttggagcag atatgcaggt tgagctggtt aataacggac ctgttaccat
    17581 tatcctagat actaaaaaga gataagaaag accaagccca gtcggcttgg tctttctcat
    17641 cgatcataaa atactccaaa aagaaatcgg ttcttgatat gcttggggga agtctctttt
    17701 caggctttgg cagatgcgat aggaagggat gagatgtcct aggatgagga gagttccctg
    17761 aaggaaaagt ggaatatcac ttaaagacac caaggagaga atcatcaggc tatcccatag
    17821 gagaatttgt aaagcaaaac gccagaatct cggtctaatc tgggaataga gttgactaaa
    17881 gtggtcacaa agttggtttg aaagataggt caatagcaca ggatgaaaga aaatgagcca
    17941 accgctataa atcaaaatcc agtcccaagt aagcccccct ttttaaatgt caaaaatgcc
    18001 agcatgattc catcaatgac aaggagttga atggttttga tgaagatgat tttttttcat
    18061 gctaaaacct ccttttcctt agagacactc ccataaagag atgtgtttgt cgtaaaagtc
    18121 tggatagttt tctcctaggt agtcagctgt catataataa aaagtagaat ggcaagcagt
    18181 gataattggc ataagagatg aaaaacgctg agaactaatg aaggctaaga gaacaaaaaa
    18241 tagaaaatca atggtgagaa cccctaaata gtagaagcga atctttttat tgatttgagg
    18301 ataaatctca gcgaattgat gtttgagtcg gacgaccaag agaaatagca ggagtccttg
    18361 agcaaggaag aaaattaaac cagagagcaa gagccactca aaagatgtct cgagtctaat
    18421 gataaaaaat gcaaatagta gcaaatcaat aactgcaatt gctataaaat ggattctata
    18481 gagttttttc atgacaagac cttcctcttt tatctaactt cattctactc caaaagaatg
    18541 ggagttacaa ctaaaatgat aaaaatagca gaagggagat tctcttaagt tggctagtat
    18601 tctttatttg agtttccttc tatgtatcta acttcttcat cattccagac aaataaagct
    18661 ccgattgcat tgaggatata aaagatgtat ttaccgatat tggcgaagtt tccttgaata
    18721 ccagcttttg tcagctgaac gaaattgtaa atcaaccaaa agccccactg agttgttagt
    18781 ttcaatgcat tcaaagcatt ggcaatgagg gacagtgcaa aggcaatagt tgttacgtag
    18841 gcaaggagat tcatcttgcc cccatatccg atatagttgg ttacaaaggc aaagaggaag
    18901 gcgatgatgg aaatgatgat ggccgccaat tttacctgtt tttggctcat ttggttgggt
    18961 ctgccttctt gcgaagcttt ccatttcttt atagcaaagg tataaatgag gaaggtgacg
    19021 ggataggtaa tgatggtcgc cttatttcca aggatataat caatagcacc ggacaaaatg
    19081 gtattaacaa taccaaagta atttccccat ttgcttaatt tccccgtgaa acgagtggac
    19141 aacatggaaa tcccaacgtt ggttaaggaa atcaatccaa agggtacaag agctgtccat
    19201 agtccccagt ctacaaattt atcgaggcgt gagttgagat aaccagatgc aatcgcaatc
    19261 ccaacgacca aagcaacccc gaagaggtca aatcatttag atgtagcaaa aatttttagt
    19321 gattttttca taggttaaac tacctttctt tttttcaaat actctaccac caaatgaaag
    19381 taaaatcaaa tgatagaaat aaaaccctga aaataaaact ttcagggttg gtaggggact
    19441 tgagaaatta gttgattttc tcgacataga gttgttttgc aatgtctata ttcacttgta
    19501 aatcctcgtc gttactgagg atagtgaagg tattgctgaa gccatcaaac tgcttgactt
    19561 ggagctggtc accgatgtga agtgagtgct tgtccagata atggagaatg tcaaaactat
    19621 cgtgcacccg agtcaggcgg taggcgccag cttccttgat atcagctagt gggaggttat
    19681 tgatttcaac gaggagttct cccttggcag gaatagttcc tccgtggggg caggttttag
    19741 ggaaacctag cagtttatct agtctttcca cgaacaggtc agagacagtg tgttccaaga
    19801 cctcagcttc ctcgtgaatc tggtcacttg tatagtctaa atgatgaact agaaaaactt
    19861 caatcaagcg gtgcttacga tagagctcag agaccagttt gagaccgagg tcagtcagta
    19921 gatagccaca ttccttgtcc tttaggatga gattttcact tttcattcgt ttgatcattt
    19981 cagttacggc agggggagag acttgcatgc gagccgcaat ttccttgttg gtaatcttat
    20041 gcaggtctat gccaatttca taaatacatt ttagatagtc ttctttgttt ggggtcattc
    20101 gtttcctctt gtctaatatc tttatctagt atatcaaaaa aagctagatt tctctagctg
    20161 tgacttttta tgttatactt attgcaagag aaaaaacgag gagatggata tgacgaaaat
    20221 agctcttctt tcagatattc atggaaatac caccgccttg gaggctgttt tggcagatgc
    20281 tcggcagcta ggagtggatg aatactggct tttgggagat attctcatgc cagggacagg
    20341 gcgtagaagg attttggact tgttggatca actaccgatt acggctagag ttttgggaaa
    20401 ctgggaagac agtctttggc atggtgtccg taaggaattg gatagtactc gccccagtca
    20461 acgctatctc ttgcgccagt gccagtatgt tttagaggaa atttccctag aagaaattga
    20521 agtgctccac aatcaacctc ttcaaattca tcgtcagttt ggggatttga cggtgggaat
    20581 tagccatcat ctgcctgata agaactgggg gcgagagttg attcatactg gcaaacaaga
    20641 ggagtttgac cgcttggtga ctcatcctcc ctgtgatatt gctgtttatg gacatattca
    20701 ccagcagttg cttcgttacg ggactggtgg gcaattgatt gtcaatccgg gttcgattgg
    20761 ccaacctttc tttttggacg ctcagctacg gaaggacttg cgggcccagt atatgatttt
    20821 ggagtttgat gacaaaggcc tggtagatat ggacttccga cgggtagact acgatgtggc
    20881 agcggaattg cagctggcta aagacctgag acttccctat tttgaggttt actatgaaag
    20941 tctggtcaat gggatccacc atactcatca tcaggaattt ttgagagaat tggctcagaa
    21001 agagggctgc gatcgggagt tagacgactg gttgaaaagt ggtaacgatt gacattacaa
    21061 ctaaaaaggg tataataata gaaaaagaag agtagaggca gggtagcctc gtaaaaagga
    21121 gaagaggatg caaattccaa gtagatttac cattgcgact catatgctga taatcattgc
    21181 cctcgagggg aaggaaagca aggtgaccag tgattttctg gctgctagtg tcggggtcaa
    21241 tcctgtcatt atcagaaaga tcttgtccca gttgaagaag gcagagctga tttcagtagc
    21301 gcgtggaacg ggcggaacag agattgtcaa ggaccttaag gatattagtc ttttagatgt
    21361 ttatcaggcg gtcgaatgtc ttggtaagac aggtcaactc ttcagtttcc atgacaatcc
    21421 gaatccaaat tgccctgtag gagctcatat tcatgatgtt ttggatcaaa aattggagag
    21481 aattcagttg actatggagg cagaacttgg tcaaaccagt ctagaaaaag tcgtggccga
    21541 tgcagagagt cagatgaagg attaagaggg ataaatgccc tcttttttct ttggataatt
    21601 atgataaaat gtagctatta aaggagtaag aaatgtatct cgttatagga attgtattag
    21661 cctttatagt gtcattttgg aaggataata gaagtttgtg gaatccagta ttatttttat
    21721 tatccctcat ttcaagttat ttttatctat cctacctttt ttataaaaat ggatacgaga
    21781 atgttcagtt agctttttat gtatttgcct ttgtcttact tccttttttg ctttttctaa
    21841 gtggcatctt tttaatctat aatggggtca ttttgttgaa acgagaggga cgttccaagc
    21901 cccattatct ctcaatgctc tttgattttt attgactatt agattctatt taaaaagact
    21961 tagaatgcac atgaaagtat gtattctagg tcttttgttt tgtatacatt taattttcaa
    22021 gagtattatc tatttttcca tgcatggtaa cgagtatcaa tcaataactg ggtaaggcga
    22081 cccaaggttt ctctttcttc tggagtgagg gattgagctt ggacaaagag atgatgaatg
    22141 tattcaagcg cctttaagga agccaagtca ttgatagagc taataccagc atcaagaata
    22201 gtgccaaaga agaggtcgaa gtagagctga agttcttcgt cagggactgt ggccacccat
    22261 tctttaaagg ttgtgtctac ttgccggcta tcactgttgg tcttatccag ttgaacgaag
    22321 tgcttgtcct caatctgcca actaaaggta tcgtgctggg cgatgccacc cagggcagta
    22381 ctctgaacga tgatttggtg agcaggaatt tccagcatca taccgataat ggaaccttgt
    22441 ggaatgaata tcttgcttct atccattatc ctttgataac ccgcagtctg tgtcaattct
    22501 tgatggagac caggtgcatc aaatgtataa actgctgtga tctgattttg caaactttgc
    22561 tcaatttggc tagcagcata gatagcgaga tttcctccct tggaatgccc agccagaata
    22621 accttttgct taggatgatg ggcaaaaaag ttctttaaat agcgaagggc gtgcttttga
    22681 gcaggaattt ccttcatata ggtcaggtgg aaatcttcct tccagccaat gatactgtca
    22741 tctgtcccac gaaagacaat cagataggta tcgaggctga cacgataagt catagccgca
    22801 aattgctttt gcagttcagg gtcgatgtcg ttgataaaat gggagagttt gcaatttttg
    22861 aagcgcttgt gttgagccaa ttcatctaat aattgaaggc gatttttgct agtaagcatg
    22921 gtgggctctc ttggaacctg aggtgctaga tctaaaagac gttgaggaag tgtggagacc
    22981 agattatcaa aggagaggta ggtgatttct attaaggtta gaatgtctaa ctcattcaag
    23041 ggaaggtcgt aataagaatc atatgcgaca tctttcagat agtcaaaaat attggccata
    23101 agagctcctt tctttttatt tatcttagca aatttccctc aaattagcta gtagcattgc
    23161 ctgtttgtac tggctaaaaa caggctattt caaattcagt ttcagaccat ctggcatgga
    23221 aaaatctgtt ataataatag aaaaggagaa gcgcatgcac aagattttat taatagaaga
    23281 tgatcaggtc attcgtcaac aggtcgggaa aatgctctct gaatggggat ttgaagtggt
    23341 cctggtagaa gactttatgg aagttttgag tctatttgtt cagtcggaac ctcatctggt
    23401 cctcatggat attggtttgc ccttgtttaa tggttatcac tggtgtcagg aaatccgcaa
    23461 gatttccaag gtacctatca tgtttctttc ttcgagagac caggctatgg atattgtcat
    23521 ggcaatcaat atgggggcgg atgactttgt gaccaagcct tttgaccagc aggttctttt
    23581 agccaaggtt cagggcttgt tgcgtcgttc ctatgagttt gggcgtgatg agagtttgct
    23641 ggaatatgct ggtgttatcc tcaataccaa atccatggat ttacattatc aagggcaagt
    23701 tttgaatttg accaagaatg aattccagat tttacgcgtg ttatttgagc atgcaggcaa
    23761 catcgtagca cgtgacgacc tgatgcggga actttggaac agtgactttt tcattgatga
    23821 taataccctc tctgtcaatg tggctcgttt gcgtaaaaag ttggaggagc agggattggt
    23881 aggatttatc gagaccaaga aaggaatagg gtacggattg aagcatgctt gattggaaac
    23941 aattttttct agcctatctg cgctcccgta gtcgtctttt tgtctatctg ctttctttgg
    24001 catttctggt cttactcttt cagtttttat ttgccagtct aggaatttac ttcctctact
    24061 ttttcctctt gtgttgcttt gtaaccatct tatttttcac ttgggacata ttggtggaaa
    24121 tgcaggtcta tcgccaggaa cttctctatg gagagaggga agccaagtct cctttggaaa
    24181 tagctttagc agaaaaatta gaagcgcgtg agatggaact ctatcagcag aggtcaaaag
    24241 cagaaagaaa actgacggat ttgctggatt actatacctt gtgggtccat cagataaaga
    24301 cccccattgc agccagtcaa ctcttagttg cagaagtggt cgaccgccaa ctgaagcagc
    24361 agctagaaca ggaaattttc aaaatcgact cctataccaa cctagtttta cagtacctgc
    24421 gtttagaaag tttccatgat gatttggtct taaagcaggt tcaaattgag gacttggtca
    24481 aggaaataat tcgtaaatat gctcttttct ttattcaaaa aggcttaaat gtcaatctac
    24541 atgaccttga taaagaaatc gtgacggata aaaagtggct gctagtggtt attgagcaaa
    24601 tcatctcaaa cagtctcaag tacaccaagg aaggtggtct ggagatttat atggatgacc
    24661 aagagctttg tatcaaagat acgggaatcg ggataaaaaa cagtgatgtt ctccgagtat
    24721 ttgaacgtgg cttttcagga tacaatggcc gtttgaccca gcagtcctct ggacttggcc
    24781 tttatctatc taagaaaatt tctgaagaac tggggcatca gattcgtatc gagtctgagg
    24841 tcgggaaagg aacgacagtg cggattcagt ttgctcaagt gaacttagtc cttgagtaaa
    24901 aatagatgag aaaaagcctc cagattggag gcttttatgc tagactctta tttctcaacg
    24961 cgtgatttgt tggcgatatc agctaggata gcttgaacaa aattatcaac tgagacagtt
    25021 tgtgtttctt tttggccgta gcgacgaacg ttgactgttt cgtcttccat ttctttgtct
    25081 ccaacaatta attggtaagg aatcttgctg gtttgtgaag cacggatctt gaactgcatt
    25141 ttttcattgc gctcatctac gtctgcacgg acaccgcggt cacggagttt cttggccact
    25201 tcccaagcgt agtccacgtg tttttcgtta gatactggga tgagggttac ttggtgtggt
    25261 gccagccatg ttgggaaggc ccccttgtag ttctcaatca agatagctgt gaagcgttcc
    25321 atagttgaga taaccccacg gtggatcatg actggacggt gatcttcgcc atcagctccg
    25381 atgtatttga ggtcgaagcg ttctggcaac aagaaatcaa gttggatagt agaaagggtt
    25441 tcttcttttc caagggcagt tttaatctgg atatccaatt ttggtccgta gaaggctgct
    25501 tcaccttcgg cttcaaagta gtccacgccc atttcatcaa gagctgcacg aagcatggtt
    25561 tgggcatttt cccacatctc atcgttatca aagtacttat gagtatcttg agggtcacga
    25621 agagagaggc ggaagcggta gtcagtcaag ttgaagtctt cataaacatc gataatcaac
    25681 tgaagggcac gttggaattc ttcttggatt tgttctggag taacgaatag gtgaccgtcg
    25741 ttgagtgaca tttcacgtac acgttgaagg ccagtgaggg caccagattt ttcgtaacgg
    25801 tgcatcatac cgatttcagc gatacggatt ggcaattcac ggtaagagtg aacatggtgt
    25861 ttgaaaactt ggatgtggtg cggacagttc attggacgaa ggacaaattc ttccccgtca
    25921 cccatgtcca tggttgggaa catgtcttct tggtaatgat cccagtgacc agaagtcttg
    25981 taaagctcaa cagaagcaag tggtggagtg tagacgtgtt ggtagccaga agccaactct
    26041 ttgtttacga tgtagcgttc caattcacga cggatagtcg caccatttgg caaccagaat
    26101 ggcaaacctt gtcccacttc ttgtgaaatc ataaagaggt caagctcttt accaagttta
    26161 cggtggtcac gttccttagc ttcttcacgc atttgaaggt agtttttcaa gtctttcttg
    26221 tcaaaccaag ctgtaccgta gatacgttgc atcatagcgt tgtcgctgtt tccacgccag
    26281 tacgcaccag ctacatggag aaggtggaag atttggatac gacctgttga tggaacgtga
    26341 ggtccacggc agaggtctac atattcaccc tgacgataga tagtcaaacc gccttcgtct
    26401 tctgagtgtt cttcaatcaa ttccaacttg taagggtcat ttttgaagat ttcacgtgcc
    26461 tcgtctttag tcacttcttc acgaatagat gggaagtttt ctttgacgat tttttgcatt
    26521 tcttcttcga tacgaggaag gtcttcgtta gagatttgac cagctgtgtt gtcagtatcg
    26581 tagtagaaac catcttcgat ggctggacca actcccaagt gaatgtctgg gaaaagacga
    26641 cgagctgctt gggcgaacaa gtgagctgct gagtgacgca agattggaag ggcatcttcg
    26701 tgatcaggtg tcacaatttc gatgcttcca tcttcagtga tagcgcgagt agtgtcgatg
    26761 agtttgccgt tgaatttacc agccaaggct tttttagcta gggaattgct gatagattgg
    26821 gcaatttcaa aagttgttac gccagattcg aattcacgaa tagcgccatc tgggaaagta
    26881 atgttaatca tgatgttctc cttttttatt atttcatagt ttctaagcat tgatttttta
    26941 tcagcagact acttccaagt cctaacgttc aattgctttt ctttatcaga gaggaagttt
    27001 tccatttccg tcagaatatc tatatccaaa cgttgagaaa gttctaatag tcaccagata
    27061 ttttctgaaa gtttttgttc cagtgtgtag ggtgtttcat catagtagcg tccttgtttt
    27121 gtcatcacca gtcgttggaa atttccaata tcattagata aagccaagag gtcttcttct
    27181 accgtccact tggaatcatg atgcttaact tccagttcgt gataagcttg tcggattgcc
    27241 caactgcgct ccactaattc ttgcaactcc ataattagta tcctaataaa aaaatgcgac
    27301 atcctcgaaa ggacgtcgca acgtggttcc accttcattt atgtacctca aaagagaggg
    27361 acacctctga ttggctctaa cgtggccacc gttttatgtt ttcataaaaa actcaagagt
    27421 agtatcagtt tagacttcct atgcgtttcc agcaaccacg cactctctag tagaaaggga
    27481 ctaagtgact tgtctctatg gattattata gcatgattgt gagatttttc aaggattttg
    27541 tgaaagtttt ttgtttttca ttttttgtag aatatgcttg atgctaatac cagaatccat
    27601 gcccaccaga gcaactgttt catagattag caagtaaatt agtataaact caccaaaggt
    27661 tatgatagta aagtaaaaga gcagtccgtt accaactaac catcaaagtg agaaacggaa
    27721 acggtagcta tagagtaacg atacaatcaa gattaccaga ggtgtaaaga agagaagatt
    27781 gtttatatag tgtaaggggg tcagaaacaa ctagcaagaa caactcataa agtggccaat
    27841 aaaagaataa tatgaccaga tagtagggga gatgggaata gaatctacgc atgataatca
    27901 cctcgtttta aaaaacagac aacttagatc tcttgctatg attattatag catgtttaaa
    27961 acaagaaagt aaatttgttg acaaagaaga tttttctttt cactagaatc atagttagtt
    28021 ttcttggtag aaatattttg ataataatta agcaagacta ttgacattga ttattaagag
    28081 tgtcacaatt gttgtaacta aaataattac aacaagagag gtataaaaaa tgaaactagc
    28141 agttattgca gcaaatggac aagcggggaa ggcaattgtt gaagaagcag tcaaacgagg
    28201 acatgaagta acggctattg ttcgttctga aaacaaaagt caagctgagt ctattattaa
    28261 aaaagattta tttgagttga caaaagatga tcttactgga tttgatgctg ttatttcagc
    28321 gtttggtgct tatacaccag atacgctacc gctccacagc aaatcaatcg aactatttaa
    28381 tcagcttctt gctggaacac agacacgttt tctagttgta gggggatcag gaagctttta
    28441 tatagatgaa acaaaaacga cacgactttt agatacgtct gattttcctg aagaatttaa
    28501 gccactagca aaagctcaag cggatgaatt ggatcttctt cgtacaaaaa ataatctcaa
    28561 ctggactttt gtcagtcctg ctgtagattt tattcccgat ggtgaaaaaa caggaaacta
    28621 cattctagca ggagaaattt ttactactaa tgaaaaagga ataagccaga ttagttatgc
    28681 agattatgct attggattgg tagatgaact tgaaaaaggt catcatataa aagaatgtat
    28741 ctctttactt gaaaaataat aactatgaga gtattaatgt ttgacagaaa atttaaatct
    28801 tggtaaaata gggattgtcg taaagacaaa taacttcttc ttggttacag gcatgccaac
    28861 ctgtcactcg gatgaagcca aataaaaagg agaaacatca tggcaatctc aaaagagaaa
    28921 aaaaatgaaa tcattgcaca atatgcacgt cacgaaggtg atacaggttc agtagaggtt
    28981 caagttgctg tccttacttg ggaaatcaac caccttaatg aacacatcaa acaacacaaa
    29041 aaagaccacg ctacttaccg tggattgatg aaaaaaatcg gtcgccgtcg taacttgctt
    29101 gcatacttgc gtaaaaacga cgttaaccgt taccgtgagt tgatcaactc tctaggactt
    29161 cgtcgctaat tcaagataca aaggctgtca aaagcacaaa gcaaaaatag gaaaattgac
    29221 gaagaaactt cagtttctag gagattttat cttttttgcc aagtgcttag gccgtgttca
    29281 attgagcata tcttgataat aaagctactc taaattgggt agcttttttg cgttgtcacc
    29341 ttacctcgct atactcaagt ataatcttcg gttacggttc ctagcactgt aaggtaaaat
    29401 aaactagctt ttctcccttc ggggagattt tttttgtttc actgaaagtt tcgtacgatc
    29461 ttcgcctcgt cgcctagtct ataaacgatt tatctagcaa gaatcatgat gctaagggcg
    29521 tcaaaaatcc gtatgaaaat agggaaatga cacagtgttc gatgagcaca aggagtttca
    29581 tctttttcat taggatttta gcccgggcta aaatcagctc tctgacttca gagggctttt
    29641 ttattgaggt tttatcggta acaattttgg agactacaaa aacctcaaat ggtatcagct
    29701 aattacacca taaaggtgcg cagttactcg gcttttcaag ccgagtagct gtatgcaagc
    29761 cccctagaag agcccactct ttacaaagta aagtatagta tgttatactt tacatggaag
    29821 tagtcactga attccagtta gaaattactt tgtaactacg ttttgaggag gagtaaaatg
    29881 ctttcctacg ttcgacatta cccactagcg atagctaaat taatgtgtct gtgctctcct
    29941 aaaatctgct gatttattac tgactaatac aggaggtttt ttttatggga cagacaatca
    30001 tatctgctat tggtgtttat atttccacca gtatcgatta tttaattatt ttaattattt
    30061 tatttgcaca gctatcacag aataaacaga aatggcatat ttatgcgggg caatatctag
    30121 gcacaggctt acttgtaggg gcgagtttag ttgctgctta tgtcgttaat ttcgtgcctg
    30181 aagaatggat ggttggattg cttggtttaa tccctatcta tttagggatt cgctttgcaa
    30241 ttgttggaga agatgcggaa gaagaagagg aagaaattat tgaaagatta gaacaaagca
    30301 aggcaaatca actgttttgg acagttacat tgctgacaat tgcgtctggc ggagataatt
    30361 taggtatcta tataccttat tttgcttcgt tagattggtc acagaccctc gtggccttgc
    30421 ttgtgtttgt aatcggcata attatctttt gcgagattag tcgggtgtta tcctctattc
    30481 cgttaatatt cgagacaatt gaaaaatacg agcgaatcat tgtgccctta gtattcattc
    30541 tacttggact atacatcatg tatgaaaatg gcacgataga gacttttctg atcgtgtaga
    30601 tttttttgtt tcactaggat tttagcccga gctcaaatca gctctctgat tttcagaggg
    30661 ctttttcatt gagtataaat ggacaatctt aaagttactc tattgtagag tggcttttga
    30721 tttgattagg agattcttat aaatatagta aaatgaaaca aaaacaggac aaatcgatca
    30781 ggacagtcaa atcgatttct aaaaatgttt taagaagtag aggtgtacta ttctagtttc
    30841 aatttgatat ataaatgaaa accttagctg tttggccaag gttcatttct tctatgcaag
    30901 ttcttctctt ttcttatctg ggttccagat gaagcttgcg ataaagctaa agatgatggt
    30961 taggatagcg aggataatag caaggatgag ggcagggatg cggataaacc accagagtgg
    31021 atttggtttt ttatcattgt gccattgttt cgtttcttcg tccagacgtt ggaattctgt
    31081 ttgaatacga ttggcgactg tttcaatgcc ttcatcattc attttcttga tatctgagat
    31141 atcgattgga tttccaaagt tcatatcgac acgttcacgg ctaatcaagc ccttcaaagt
    31201 catgggaccg gtgtaggtaa ccggcatgat acggaccttg gccattttgg caatcagtgc
    31261 tgcgcccccc ttgacatcgt ttgagtggcg gctaccactt ggaaacatga tgagagagcg
    31321 gtcacttttt ttgagaacgt tgataggata tttgatggct gaggcgctgg gattttcacg
    31381 gtcgatggga aaggcgccac acatacgaat ccaccaacca aagatacggt tggtaaagag
    31441 ttcttttttt gccataaaga tgaactgttt tggcttggtc gcaaaggcca tataaacagg
    31501 atcccaccag gtacggtgag gcgcaactaa aatataattt tcatcttgat taggaatttt
    31561 atcagtatta tgatagtgag cattgccatt gatggaccat aagagcaata caactaatcc
    31621 acgcaaataa gtataaaaca tgcgatctcc ttcgattgtt ttcttgttat tattatacct
    31681 tatcaaagga gggctggcaa acttttccct tgactagatg catatttggg atgaaattag
    31741 aattctgtta aaaaaaatga tataatagaa tttatggata aaaataagat tatgggatta
    31801 acccaaagag aagtcaagga aagacaggct gagggtttgg tcaatgactt taccgcatca
    31861 gccagtacca gcacttggca aatcgttaaa cgaaatgtct ttaccctttt taacgctttg
    31921 aactttgcca ttgctttggc ccttgccttt gtgcaggctt ggagcaatct ggtcttcttt
    31981 gctgttatct gctttaacgc tttttctggg attgtgaccg agctacgagc caaacacatg
    32041 gtggacaagc tcaatctcat gaccaaggaa aaggtcaaaa ccatccgtga tggtcaggaa
    32101 gttgctctta atcctgaaga attagtgcta ggagatgtca ttcgtttgtc tgcaggagag
    32161 cagattccta gtgatgcctt ggttttggaa ggctttgcgg aagtcaatga agccatgtta
    32221 acgggagaaa gtgatttggt gcaaaaggaa gttgacggct tacttttgtc aggaagtttc
    32281 ctagccagtg ggtcagtttt atctcaagtt caccatgtcg gtgcagacaa ctatgctgcc
    32341 aaacttatgc tggaagccaa gaccgttaaa cccatcaact cccgtatcat gaaatcgctg
    32401 gacaagttgg ctggttttac tgggaagatt atcattccct ttggtctggc tctcttgctg
    32461 gaagccttgc ttttaaaagg cctgcctctc aagtcatccg ttgtaaactc gtcgacagct
    32521 cttttgggaa tgttgcctaa gggaattgcc cttttgacca ttacttcgct cttgactgca
    32581 gtgattaagt tgggcttgaa aaaggtcttg gtgcaggaga tgtactctgt tgagaccttg
    32641 gcgcgcgtgg atatgctctg tctggacaag acgggtacca tcacccaagg aaagatgcag
    32701 gtggaggctg ttcttccgtt gacggaaacg tatggtgaag aggctattgc cagcatcttg
    32761 accagctaca tggcccatag tgaggataag aatccaactg cccaagccat tcgccagcgt
    32821 tttgtgggag atgttgctta tcctatgatt tccaatcttc ccttctcgag cgaccgcaag
    32881 tggggggcta tggagttaga aggcttgggg acagttttct taggggcacc tgagatgttg
    32941 ctggattctg aggtcccaga agccagagag gccttggaga gaggttcacg tgtcttggtc
    33001 ttagctctca gtcaggagaa attagaccat cacaaaccac agaaaccatc tgatattcag
    33061 gctctagcct tgctggaaat cttggacccc attcgagagg gagcagcaga gacgctggac
    33121 tatctccgtt ctcaagaggt gggactcaag attatctctg gtgacaatcc agttacggtg
    33181 tccagcattg cccagaaggc tggttttgcg gactatcaca gctatgtaga ttgctcaaaa
    33241 atcaccgatg aggaattgat ggccatggcg gaggagacag ctattttcgg acgtgtttcc
    33301 cctcatcaaa agaaactcat catccaaacg ttgaaaaaag cgggtcatac aacggctatg
    33361 acaggggacg gggttaatga tatcttggcc cttcgtgagg cggattgttc tatcgtgatg
    33421 gcggagggag atccagcaac ccgtcagatt gccaatctgg ttctcttgaa ctcagacttt
    33481 aatgatgttc ctgagattct cttcgagggt cgtcgcgtgg tcaataacat tgcccacatc
    33541 gccccgattt tcttgataaa gaccatctac tcattcttgc tcgcagttat ctgtatcgcc
    33601 agtgctttac taggtcggtc tgaatggatc ttgattttcc ccttcattcc aatccagatt
    33661 accatgattg accagtttgt ggaaggtttc ccaccattcg ttctgacttt tgagcgaaat
    33721 atcaaacctg ttgagccaaa tttcctcaga aaatccatgc ttcgtgccct accaagcgct
    33781 ctcatggtcg tcttcagcgt cctgtttgtg aaaatatttg ggagtagcca aggttggtct
    33841 gagttagaaa tctcaactct cctctattat ctcttggggt caattggttt cttatccgta
    33901 tttagagcct gcatgccatt caccctatgg cgtgtcctct tgattgtctg gtcagtagga
    33961 ggcttcctag ccacagctct cttcccaaga atccaaaaac tgcttgaaat ttcaacctta
    34021 acaggacaaa cattacctgt ttatggtgtc atgatgttgg tctttaccgt gattttcatc
    34081 ctgaccagtc gctatcaagc tagaaaataa agaaagactg caatctgtgg attgcagttt
    34141 ttttaggtac aagattgcca gccgaaatgt ggtataataa gaggtaatag agttttggaa
    34201 agtgagagaa gatgatttca aagagattag aattggtagc ttcctttgtg tcacaggggg
    34261 ctattttact agatgtggga agtgaccatg cttatctgcc tatcgagttg gttgagagag
    34321 gccaaatcaa aagcgctatt gcaggtgagg tggtggaagg tccctatcag tctgcggtta
    34381 aaaatgttga ggctcacggc ctaaaggaga aaatccaagt ccgtttagcc aatggcttgg
    34441 cagcttttga agagactgac caagtgtctg tcattaccat tgctggcatg ggtggtcgtt
    34501 tgattgctag gattttagaa gaaggtttgg ggaagttagc taatgtagaa cgtttgatcc
    34561 tccagcccaa taatcgtgaa gacgacttgc gtatctggct acaggatcat ggattccaga
    34621 ttgtagcaga aagcatctta gaagaagctg gaaagtttta tgagattttg gtggtggaag
    34681 caggacaaat gaagctatca gccagtgatg ttcgctttgg tcccttcttg tccaaagaag
    34741 tcagtccagt atttgtccaa aaatggcaaa aagaagctga gaagctagag ttcgccctcg
    34801 gacaaatccc agaaaaaaat ctggaagaac gtcaagttct agtagataag attcaagcta
    34861 tcaaggaggt gctccatgtt agcaagtgaa gtgatccaag cttatgaagc cttttgccct
    34921 caggaatttt ctatggaggg agacagctgt ggtctgcaaa ttggcacttt agacaagggt
    34981 atccaaaggg tcatggttgc cctcgatatt cgtgaagaga cggtggctga agccattgaa
    35041 aagggtgtag acttgattat cgtcaagcac gcgcctatct ttcgtcctat caaggacttg
    35101 cttgccagcc gtccgcaaaa tcagatttac atcgacctga ttaagcatga tatcgcagtt
    35161 tatgtcagcc ataccaatat tgatatcgtt gaaaatgggc tcaatgactg gttttgtcag
    35221 atgctaggaa tcgaggagac gacttatctg caggaaacag gtccagaacg tggaattgga
    35281 cgtattggga atattcagcc tcagacattt tgggaattgg cccaacaggt caagcaagtc
    35341 tttgacctag atagccttcg aatggtgcat tatcaagaga atgatttgca gaagcctatt
    35401 tcaagagtag caatttgtgg tggaagcggg cagtctttct ataaggatgc tttggcaaag
    35461 ggggcagatg tctatatcac tggtgacatc tactaccata ctgctcagga tatgctgtct
    35521 gatggcttgt tagcattgga tccaggtcac tatatcgaag tgctttttgt ggaaaaaatc
    35581 gcaacactcc ttactcaatg gaaagagaaa aaaggctggg aactagagat tttacctagt
    35641 caagcatcga ccaatccttt ccgtcatatc tagttagaaa gtgaagacaa tgaaaaaagt
    35701 tgccattatt ggagcaggaa ttgtgggagc aacagctgcc tactacctct cgagagaaag
    35761 tgacctagag gtgaccgttt ttgaccatga gcaaggtcaa gccaccaagg ccgcagcagg
    35821 aattatcagt ccttggtttt ccaaacgccg taataaagcc tggtacaaga tggcgcgctt
    35881 gggggctgac ttttatgtgg atttattagc tgatttagag aaatcaggac aaaaaatcga
    35941 cttttaccag cgttcgggag tctttctctt gaaaaaggat gaatccaagt tggaagaact
    36001 ttatcaactg gccctccagc gcagagaaga atctcccttg atagggcaat tagccattct
    36061 ggaccaagct tcagctaatg aattattccc tggtttgcag ggatttgacc gcctgctcta
    36121 tgcttctggt ggagcgagag tagatggcca actcttggta actcgtctgc tagaagccag
    36181 tcatgtcaag ctggtcaaag aaaaagtgac tctgacactc ttatcatcag gctaccagat
    36241 tggcgaagag gtgtttgatc aggttatttt ggcaacggga gcttggttgg gggacatgtt
    36301 agagccttta ggttatgaag tggatgtccg tcctcaaaaa ggacaactac gagattatca
    36361 gcttgcccaa gacatggaag attaccctgt tgtcatgcca gaaggggagt gggatttgat
    36421 tccctttgca ggtgggaaat tatccttggg cgctacccat gaaaatgaca tgggatttga
    36481 tttgacggta gatgaaccct tgctccaaca aatggaggag gcggccttgc ctcattaccc
    36541 agttttagct agagcgactt caagggctga gcgtgtggga atccgtgcct ataccagtga
    36601 tttctctccc ttctttgggc aggtgccaga attggcaggt gtctatgtag ccagtggact
    36661 aggttcatca ggcctcacaa ctggtcctat cattggttac catctagccc aactgatcca
    36721 agacaaggag ttgaccttgg accctctaaa ttacccaatt gaaaactatg tcaaacgagt
    36781 aaaaagcgaa taatactcaa tgaaaatcaa agaacaaact aggaaactag ccgcggatta
    36841 ctcaaagtac tg
//
LOCUS       DBERMM010000018        36414 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.018, whole genome shotgun sequence.
ACCESSION   DBERMM010000018 DBERMM010000000
VERSION     DBERMM010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 36414)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36414)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36414
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.018"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            312..809
                     /locus_tag="ACL8AS_001126"
     CDS             312..809
                     /locus_tag="ACL8AS_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_function: GO:0033745 - L-methionine-(R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GAF domain-containing protein"
                     /protein_id="HGS1228998.1"
                     /translation="MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPN
                     TVFAGFYLFDGKELVLGPFQGGVSCIRIALGKGVCGEAAHFQETVIVGDVTTYLNYIS
                     CDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDAMDRDYLEQFVAILLEKTTWDFTM
                     FEEKS"
     gene            809..2464
                     /gene="dnaX"
                     /locus_tag="ACL8AS_001127"
     CDS             809..2464
                     /gene="dnaX"
                     /locus_tag="ACL8AS_001127"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009360 - DNA polymerase III complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HGS1228999.1"
                     /translation="MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSG
                     PRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDE
                     IREIRDKSTYAPSLARYKVYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
                     IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALS
                     ILDQALSLTQGNELTTAISEEITGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGK
                     SMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLFEMIRLATVSLADIK
                     SSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNVGAVPKQVA
                     PAPSRPATGKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKA
                     LLVGSQPVAANEHHAILAFESNFNAGQTMKRDNLNTMFGNILSQAAGFSPEILAISME
                     EWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED"
     gene            2492..2686
                     /locus_tag="ACL8AS_001128"
     CDS             2492..2686
                     /locus_tag="ACL8AS_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3272 domain-containing protein"
                     /protein_id="HGS1229000.1"
                     /translation="MNKQQFIIMALFTAAETYFFNEAWMTGRYIMAAFWAILLFRNFR
                     VSYVMGKIVDVIDQHFNRKD"
     gene            2836..3606
                     /gene="sufC"
                     /locus_tag="ACL8AS_001129"
     CDS             2836..3606
                     /gene="sufC"
                     /locus_tag="ACL8AS_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000114488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="HGS1229001.1"
                     /translation="MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKST
                     LSAAIMGNPNYEVTKGEVLFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLR
                     AAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLL
                     MLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHV
                     MMEGRVVLSGGPELAARLEREGYAKLAEELGYDYKEEL"
     gene            3634..4896
                     /gene="sufD"
                     /locus_tag="ACL8AS_001130"
     CDS             3634..4896
                     /gene="sufD"
                     /locus_tag="ACL8AS_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufD"
                     /protein_id="HGS1229002.1"
                     /translation="MTRENIKLFSEMHAEPSWLADLRQKAFDKIETLELPVIERVKFH
                     RWNLGDGTITENEPSANVPDFTALDHHLKLVQVGTQTVFEQTPVELAEQGVVFTDFHS
                     ALEEIPELIEEFFMSSVKYDDDKLAAYHTAYFNSGAVLYIPDNVEITEPIEGIFYQDS
                     DSNVPFNKHIMIIAGKNSKISYLERLESRGEGSDKVTANITVEVIARSGAQVKFAAID
                     RLGENVTAYISRRGKLGNDASIDWAIGVMNEGNVVADFDSDLIGNGSHADLKVVALSS
                     GRQVQGIDTRVTNYGCNSIGNILQHGVILEKATLTFNGIGHIIKGAKGADAQQESRVL
                     MLSDQARSDANPILLIDENDVTAGHAASIGQVDPEDMYYLMSRGLDKATAERLVVRGF
                     LGSVIVEIPVKEVRDEMIATIEEKLSKR"
     gene            4907..6133
                     /locus_tag="ACL8AS_001131"
     CDS             4907..6133
                     /locus_tag="ACL8AS_001131"
                     /EC_number="2.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_function: GO:0031071 - cysteine desulfurase activity
                     [Evidence IEA];
                     GO_process: GO:0006534 - cysteine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HGS1229003.1"
                     /translation="MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINS
                     YYEQDNANVHRGVHTLAERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVAR
                     FAEEILTEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
                     KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFA
                     FSGHKMAGPTGIGVLYGKEKYLEQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPN
                     MAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVI
                     AFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPALARASFYIYNTKADCDK
                     LVDALQKTKEFFNGTF"
     gene            6120..6560
                     /gene="sufU"
                     /locus_tag="ACL8AS_001132"
     CDS             6120..6560
                     /gene="sufU"
                     /locus_tag="ACL8AS_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly sulfur transfer protein
                     SufU"
                     /protein_id="HGS1229004.1"
                     /translation="MALSKLDSLYMAVVADHSKNPHHQGKLEDAGQISLNNPTCGDVI
                     NLSVKFDAEDRLEDIAFLNSGCTISTASASMMTDVVLGKTKQEILELATIFSEMVQGQ
                     KDERQGQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQ"
     gene            6614..8026
                     /gene="sufB"
                     /locus_tag="ACL8AS_001133"
     CDS             6614..8026
                     /gene="sufB"
                     /locus_tag="ACL8AS_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017769002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufB"
                     /protein_id="HGS1229005.1"
                     /translation="MAEERVEPKPIDLGEYKFGFHDDVEPVLSTGKGLNEGVIRELSA
                     AKGEPEWMLEFRLKSYETFKKMPMQTWGADLSEIDFDDLIYYQKPSDKPARSWDDVPE
                     KIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEFQKLGIIFTDTDSALKEYPD
                     LFKQYFAKLVPPTDNKLAALNSAVWSGGTFIYVPKGVKVDIPLQTYFRINNENIGQFE
                     RTLIIVDEGASVHYVEGCTAPTYSSNSLHAAIVEIFALDGAYMRYTTIQNWSDNVYNL
                     VTKRAKAQKDATVEWIDGNLGAKTTMKYPSVYLDGEGARGTMLSIAFANAGQHQDTGA
                     KMIHNAPHTSSSIVSKSIAKGGGKVDYRGQVTFNKNSKKSVSHIECDTIIMDDLSASD
                     TIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELP
                     MEYAVELNRLISYEMEGSVG"
     gene            complement(8257..9498)
                     /gene="pbp3"
                     /locus_tag="ACL8AS_001134"
     CDS             complement(8257..9498)
                     /gene="pbp3"
                     /locus_tag="ACL8AS_001134"
                     /EC_number="3.4.16.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase PBP3"
                     /protein_id="HGS1229006.1"
                     /translation="MKKIFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILY
                     EKDATQPVEIASITKLITVYLVYEALENGSITLSTPVDISDYPYQLTTNSEASNIPME
                     ARNYTVEELLEATLVSSANSAAIALAEKIAGSEKDFVDMMRAKLLEWGIQDATVVNTT
                     GLNNETLGDNIYPGSKKDEENKLSAYDVAIVARNLIKKYPQVLEITKKPSSTFARMTI
                     TSTNYMLEGMPAYRGGFDGLKTGTTDKAGESFVGTTVEKGMRVITVVLNADHQDNNPY
                     ARFTATSSLMDYISSTFTLRKIVQQGDAYQDSKAPVQDGKEDTVTAVAPEDIYLIERV
                     GNQSSQSVQFTPDSKAIPAPLEAGTVVGHLTYEDKDLIGQGYITTERPSFEMVADKKI
                     EKAFFLKVWWNQFVRFVNEKL"
     gene            9601..10710
                     /gene="cozE"
                     /locus_tag="ACL8AS_001135"
     CDS             9601..10710
                     /gene="cozE"
                     /locus_tag="ACL8AS_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell elongation protein CozE"
                     /protein_id="HGS1229007.1"
                     /translation="MFRRNKLFFWTTEILLLTIIFYLWRQMGSLINPFVSVLNTIMIP
                     FLLGGFLYYLTNPIVTFLNKVCKLNRLLGILITLCTLVWGMVIGVVYLLPILINQLSS
                     LIISSQTIYSRVQDLIIDLSNYPALQNLDVEATIQQLNLSYVDILQNILNSVSNSVGS
                     VLSALISTVLILIMTPVFLVYFLLDGHKFLPMLERTILKRDRLHIAGLLKNLNATIAR
                     YISGVSIDAIIIGCLAYIGYSIIGLKYALVFAIFSGVANLIPYVGPSIGLIPMIIANI
                     FTDPHRLLIAVIYMLVVQQVDGNILYPRIVGSVMKVHPITILVLLLLSSNIYGVVGMI
                     VAVPTYSILKEISKFLSRLYENHKIMKERERELAK"
     gene            11356..11703
                     /gene="ssrA"
                     /locus_tag="ACL8AS_001136"
     tmRNA           11356..11703
                     /gene="ssrA"
                     /locus_tag="ACL8AS_001136"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(11873..11960)
                     /locus_tag="ACL8AS_001137"
     tRNA            complement(11873..11960)
                     /locus_tag="ACL8AS_001137"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(11924..11926),aa:Ser,seq:gga)
     gene            12123..12863
                     /locus_tag="ACL8AS_001138"
     CDS             12123..12863
                     /locus_tag="ACL8AS_001138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HGS1229008.1"
                     /translation="MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELE
                     AENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGT
                     TTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
                     QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVA
                     PLKRAIVITSQGHELLQVIKEKTEVIEV"
     gene            12860..13771
                     /gene="pfkB"
                     /locus_tag="ACL8AS_001139"
     CDS             12860..13771
                     /gene="pfkB"
                     /locus_tag="ACL8AS_001139"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015605104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008662 - 1-phosphofructokinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HGS1229009.1"
                     /translation="MIYTVTLNPSIDYIVRLDQVKVGSVNRMDSDDKFAGGKGINVSR
                     VLKRLNIPNTATGFIGGFTGKFITDTLAEEEIETRFVQVAEDTRINVKIKADQETEIN
                     GTGPTVESVQLEELKAILSSLTAEDTVVFAGSSAKNLGNVIYKDLISLTRQTGAQVVC
                     DFEGQTLIDSLDYQPLLVKPNNHELGAIFGVKLESLDEIEKYARELLAKGAQNVIISM
                     AGDGALLVTSEGAYFAKPIKGTVKNSVGAGDSMVAGFTGEFVKSKDAVEAFKWGVACG
                     TATTFSDDLATAEFIKETYGKVEVEKR"
     gene            13768..15720
                     /locus_tag="ACL8AS_001140"
     CDS             13768..15720
                     /locus_tag="ACL8AS_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022877 -
                     protein-N(PI)-phosphohistidine-fructose phosphotransferase
                     system transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-specific PTS transporter subunit EIIC"
                     /protein_id="HGS1229010.1"
                     /translation="MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTDHGYVTDFETF
                     KEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFM
                     IAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
                     ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDI
                     RKAKAIIIAADKAVEMDRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAK
                     AATASNEKQSLGGAFYKHLMSGVSQMLPFVIGGGIMIALAFLIDGALSVPNENLGNLG
                     SYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIP
                     YAAGGEATSTLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLG
                     TILTGFVMLAVNIPMAAINTAMNDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAY
                     VFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSGLTNIIM
                     GLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNA
                     LLYLVSVLVGAIVSGVVYGYLRKPQA"
     gene            15857..18109
                     /locus_tag="ACL8AS_001141"
     CDS             15857..18109
                     /locus_tag="ACL8AS_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HGS1229011.1"
                     /translation="MERKEAIQRMLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGS
                     LAYLAIFGLLIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGT
                     MAQVVTDLTGFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWS
                     VYDIAEFFSRGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPP
                     VDMETGEILTEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAK
                     EALEYKLPSLQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVT
                     KYEVKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATVSFR
                     ELWEQSQTKAENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASI
                     LMKARPDQVKFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYEL
                     FAKVGVRNIAGFNAKVEEFNSQSEYKQIPLPFIVVIVDELADLMMVASKEVEDAIIRL
                     GQKARAAGIHMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLL
                     GRGDMLFKPIDENHPVRLQGSFISDDDVERIVNFIKAQADADYDESFDPGEVSENEGE
                     FSDGDAGGDPLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEIAGVIGPAE
                     GTKPRKVLQQ"
     gene            complement(18154..18582)
                     /locus_tag="ACL8AS_001142"
     CDS             complement(18154..18582)
                     /locus_tag="ACL8AS_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6556 family protein"
                     /protein_id="HGS1229012.1"
                     /translation="MSNYRRTSKPKTEHIKKGFTVFQKTVATIASILGLITASITIMN
                     ALDNNKNIKKEPTTSQTTTIVKEIQKESPKENTSPTKETNTSQEKTQQEETPKSSVKE
                     EKKEDQKTATQDSSTPASSKPATENEKQSNAPTSENKSNQ"
     gene            18720..19862
                     /locus_tag="ACL8AS_001143"
     CDS             18720..19862
                     /locus_tag="ACL8AS_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase family protein"
                     /protein_id="HGS1229013.1"
                     /translation="MIYFDNSATTKPYPEALETYMQVASKILGNPSSLHSLGDQATRI
                     LDASRQQIADLIGKKSDEIFFTSGGTEGDNWVIKGVAFEKAQFGKHIIVSAIEHPAVK
                     ESALWLKSQGFEVDFAPVDKKGLVDVEALAGLIRPDTILVSIMAVNNEIGSIQPIEAI
                     SEFLADKPTISFHVDGVQALTKIPTEKYLTERVDFATFSSHKFHGVRGVGFVYIKSGK
                     KITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIRQALL
                     NHPDIFVFSDEENFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGT
                     LIAMGVDKDKAKSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR"
     gene            19871..21085
                     /gene="thiI"
                     /locus_tag="ACL8AS_001144"
     CDS             19871..21085
                     /gene="thiI"
                     /locus_tag="ACL8AS_001144"
                     /EC_number="2.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0140741 - tRNA-uracil-4 sulfurtransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uracil 4-sulfurtransferase ThiI"
                     /protein_id="HGS1229014.1"
                     /translation="MQYSEIMIRYGELSTKGKNRMRFINKLRNNISDVLSIYTQVKVT
                     ADRDRAHAYLNGADYTAVAESLKQVFGIQNFSPVYKVEKSVEVLKSSVQEIMRDIYKE
                     GMTFKISSKRSDHNFELDSRELNQTLGGAVFEAIPNVQVQMKSPDINLQVEIREEAAY
                     LSYETIRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPG
                     ALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRITDRIR
                     EVRNGLVIINGESLGQVASQTLESMKAINAVTNTPIIRPVVTMDKLEIIDIAQEIDTF
                     DISIQPFEDCCTIFAPDRPKTNPKIKNAEQYEARMDVEGLVERAVAGIMITEITPQAE
                     KDEVDDLIDNLL"
     gene            21220..22033
                     /locus_tag="ACL8AS_001145"
                     /pseudo
     CDS             21220..22033
                     /locus_tag="ACL8AS_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076725.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
     gene            22055..22794
                     /locus_tag="ACL8AS_001146"
                     /pseudo
     CDS             22055..22794
                     /locus_tag="ACL8AS_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546805.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
     gene            22807..23973
                     /locus_tag="ACL8AS_001147"
     CDS             22807..23973
                     /locus_tag="ACL8AS_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HGS1229015.1"
                     /translation="MNYLVISPYYPQNFQQFTIELANKGITVLGIGQESYEQLDEPLR
                     NSLTEYFRVDNLENIDEVKRAVAFLFYKHGPIDRIESHNEYWLELDATLREQFNVFGA
                     KPEDLKKTKYKSEMKKLFKKAGVPVVPGAVIKTEADVDQAVKEIGLPMIAKPDNGVGA
                     AATFKLETEDDINHFKQEWDHSTLYFFEKFVTSSEICTFDGLVDKDGKIVFSTTFDYA
                     YTPLDLMIYKMDNSYYVLKDMDPKLRKYGEAIVKEFGMKERFFHIEFFREGDDYITIE
                     YNNRPAGGFTIDVYNFAHSLDLYRGYAAIVAGEEFPASDFETQYCLATSRRANAHYVY
                     SEEDLLAKYSQQFKVKKVMPAAFAELQGDYLYMLTTPSRQEMDQMIADFGQRQE"
     gene            24481..25974
                     /locus_tag="ACL8AS_001148"
     CDS             24481..25974
                     /locus_tag="ACL8AS_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HGS1229016.1"
                     /translation="MITGELKNKIDQLWEILWTEGNANPLTNIEQLTYLLFMKDLDSV
                     ELGRESDAEFLGIPYEGVFPKDKPEYRWSTFKNIGDAQEVYRLMTQEIFPFIKNLKGD
                     TDDTAFSRYMREAIFQINKPATLQKAISILDVFPTRGLDVDFDNDKQSITDIGDIYEY
                     LLSKLSTAGKNGQFRTPRHIIDMMVELMQPTIKDIISDPAMGSAGFLVSASRYLKRKK
                     DEWETNTDNINHFHNQMFRGNDTDTTMLRLGAMNMMLHGVENPQISYLDSLSQDNEEA
                     DKYTLVLANPPFKGSLDYNSTSNDLLATVKTKKTELLFLSLFLRTLKPGGRAAVIVPD
                     GVLFGSSKAHKGIRQEIVENHKLDAVISMPSGVFKPYAGVSTAILIFTKTGNGGTDKV
                     WFYDMKADGLSLDDKRQPISDNDIPDIIERFHHLEKEAERQRTDQSFFVPVAEIKEND
                     YDLSINKYKEIEYEKVEYEPTEVILKKINDLEKEIQAGLAELEKLLK"
     gene            25987..27108
                     /locus_tag="ACL8AS_001149"
     CDS             25987..27108
                     /locus_tag="ACL8AS_001149"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1229017.1"
                     /translation="MKKVKLGEVCEILSGYAFKSSQFNDNKIGLPLIRIRDVERGFSD
                     TYFEGTYPEEYLIKNGDLLITMDGSFILKKWEGDLALLNQRVCKIKITDKSVDEGYIS
                     WLIPKFLKEIEDKTPFVTVKHLSVAKIKDISFVLPNKLEQKLIAKKLNTISQIYDFRK
                     IQSEKFNELVKSRFNEMFGENKIFESIDNLFDIIDGDRGKNYPKSDELFSEEYCLFLN
                     TKNVTKNGFSFDTKQFITKTKDKLLRKGKLERYDIVLTTRGTVGNVAYYDELIKYKHL
                     RINSGMVILRPKTPNLNQKFIIHVLRNNNYSRVISGSAQPQLPITKLKKILLPLPPLA
                     LQNEFADFVVQVDKSQLAIQKSLEELETLKKSLMQEYFG"
     gene            27168..27404
                     /locus_tag="ACL8AS_001150"
     CDS             27168..27404
                     /locus_tag="ACL8AS_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbrB family transcriptional regulator"
                     /protein_id="HGS1229018.1"
                     /translation="MVVKTRKQGNSITITIPSEFNIPSGVKYEAKLLPSGEIIFTPEE
                     LGQQVSYVSDDAFDLNLDKIFDEYDDVFKALVEK"
     gene            27401..27814
                     /locus_tag="ACL8AS_001151"
     CDS             27401..27814
                     /locus_tag="ACL8AS_001151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="HGS1229019.1"
                     /translation="MTIYLTEKQIEKINALAIQRYSPNEKIQTVSSSALNMIVNLPEQ
                     FVFGKSLYPTIFDKATILFVQLIKKHVFANANKRTAFFVLVKFLQLNGYRFSVTVEEA
                     VKMCVTIAVEALTDEKMTSYSKWVSEHSVREKVKK"
     gene            27932..28897
                     /gene="xerA"
                     /locus_tag="ACL8AS_001152"
     CDS             27932..28897
                     /gene="xerA"
                     /locus_tag="ACL8AS_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008907 - integrase activity [Evidence
                     IEA];
                     GO_function: GO:0009037 - tyrosine-based site-specific
                     recombinase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase/integron
                     integrase"
                     /protein_id="HGS1229020.1"
                     /translation="MESKVTIIMQEMLPLLNNEQLLALRESLEHHLVDGKKQQKYSNN
                     NLLQLFITAKQVEGCSSKTIRYYQRTIENLFNAIKESVTQLTTDDLRSYLANYQSEKD
                     CSKANLDNIRRILSSFFAWLEQEEYIIKNPIRRIKKIKTEQNVKETYTDEHLEIMRDN
                     CENLRDLAIIDLLASTGMRVGELVQLNRSDIDFENRECVVFGKGKKERPVYFDARTKI
                     HLRNYLNDRKDSHPALFVTLVGKAQRLGIAGVEIRLRKLGDKLGIQKVHPHKFRRTLA
                     TKAIDKGMPIEQVQKLLGHSKIDTTLAYAMVNQNNVKHSHQKFIS"
     gene            28931..29506
                     /locus_tag="ACL8AS_001153"
     CDS             28931..29506
                     /locus_tag="ACL8AS_001153"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1229021.1"
                     /translation="MKKVKLGQVATFINGYAFKPQDWSSEGKEIIRIQNLTKTSKGIN
                     YYSGTIDKKYIVEAGDILISWSGTLGVFQWCGRSAVLNQHIFKVVFDKIDIDKSYFKY
                     VVEKGLQDAVKHTHGSTMKHLTKKYFDNIMVSYTNLGEQQRIASELDLLSKLILRRQE
                     QLEELNLLVKSQFACEIAIKVWRNSLKFSII"
     gene            29536..32886
                     /locus_tag="ACL8AS_001154"
     CDS             29536..32886
                     /locus_tag="ACL8AS_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000526318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HGS1229022.1"
                     /translation="MGNFSFLLKNDEYESFSKPCIEAENMIATSTVATAFMARRALEQ
                     AVHWIYSHDSYLEAPYCATLSSLVWDDDFRDIVDSELHKQIVLLIRWGNHAAHGGEIK
                     EREAILALHHLYQFVNFIDYCYSNEFVERYFDEKCLPLSANIKYRETPQSMIKLQDSL
                     PELPDFHEQMAAQSVEVQETYTEKRETAAQRQDVPFHIEQLSEAETRKLFIDIDLRLA
                     GWIFEENCRVEIAVDGLKHGSGIGYCDYVLYGKNGKILAIVEAKKASVNPEVGEVQVK
                     EYAEALEKHIGYQPICFITNGLKHYILDGPNRRQIAGFYSQEELQLVMDRRHLQKPLE
                     DISSKIRDDISGRHYQKHAIASVCEAFSDHRRQALLVMATGAGKTRTAVSLVDILSRH
                     NWVKNVLFLADRTSLVKQAYDSFRKLLPDLSVCNFLEDKEGAQSSRMVFSTYPTMIGA
                     ISGQEEVNQRPFTVGHFDLIIIDESHRSIYQKYKSIFDYFDARIVGLTATPRQDLDKN
                     TYGFFNLENGVPTYAYDLEEAVKDGYLVAYHSIETKLKLPTDGLHYDDLSEEEKEHFD
                     SKFEDDSCEKDIDGSVFNSFVFNKSTVEIVLNELMTRGIQTASGDEIGKTIIFAKNHD
                     HAEYIRGIFNNRYPEKGSDYAQVIDYSIKHYQTLIDDFKIKEKYPQIAISVDMLDTGI
                     DVPEVVNLVFFKKVRSKTKFWQMIGRGTRLCKDLFGPEQDKENFLVFDYGDNFDYFRA
                     DPRDGEGRHIVSLTQRLFNIKVDLIRELQGLQYQEEQFARAYRQQLVSELQGRIESLN
                     ELDFRVRMVLDTVYSYRKLESWQNLTAVTSETIQKNLSPLLFDEDKEDEMARRFDLWL
                     LHIQLGQLTAKSSTVHISQVMKTARALSAIGNIPQVFEQAEIIRKVQEPEFWKEVNLS
                     DLEKIRLAIRDLLQFLDKTDRKPYYVNFEDRILSTVHETTAFLQVNDLRSYNEKVEHY
                     LKTHLDEESISKLYHNKKLTSDDMLALEKLLWEKLGSKADYQSHYENKAIPRLVREII
                     GLDRESANRIFSKFLSDENLNARQISFVKLIVDYIVENGFLETKVLTQEPFKSYGSVQ
                     LLFQHQLPVLRNIVQIIELINNRAGEAA"
     gene            33157..33357
                     /locus_tag="ACL8AS_001155"
     CDS             33157..33357
                     /locus_tag="ACL8AS_001155"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229023.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDKTDEVSSKHGFEVVDETDEVS
                     NHTYGKATLTRIEEIFEEYKSS"
     gene            complement(33473..33943)
                     /locus_tag="ACL8AS_001156"
     CDS             complement(33473..33943)
                     /locus_tag="ACL8AS_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001043003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HGS1229024.1"
                     /translation="MNKSEHRHQLIRALITKNKIHTQAELQALLAKNDIQVTQATLSR
                     DIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGL
                     AQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE"
     gene            complement(33960..36233)
                     /locus_tag="ACL8AS_001157"
     CDS             complement(33960..36233)
                     /locus_tag="ACL8AS_001157"
                     /EC_number="3.4.14.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008239 - dipeptidyl-peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Xaa-Pro dipeptidyl-peptidase"
                     /protein_id="HGS1229025.1"
                     /translation="MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRF
                     FFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDV
                     FRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLAT
                     FSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKA
                     SDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDY
                     FLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVK
                     ADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGG
                     YPGEDFDSLAELTYSRNLLAGDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYL
                     LNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSID
                     FRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQ
                     AIQNQYPDKDFERYGKTYQTFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSS
                     TNKGLLSAQLLEFGQKKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKG
                     YLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNT
                     DYHLTVDLAQSMLTLPC"
BASE COUNT        11103 a         6454 c         7895 g        10962 t
ORIGIN      
        1 gcctcataat ccagcttagc gataatttct ttgtgggtat ccatattgat gatatctaga
       61 atcttgatgt ttgggtcttt aatatcgagc agttttgtga taaaatgtaa ttgttccata
      121 tgaatctttc taatgagttg tttggtcgct tttcattata ggtcatatgg gacttttttt
      181 ctacacaaaa taggctccat aatatccata ggggatttac ccactacaaa tattatagag
      241 cccaaaatcc tttgtttact aaacaaggga tttttctttt gtctctgctc cttttttgat
      301 ataatagttc tatgttaaaa tcagaaaaac aatcacgtta tcaaatgtta aatgaagaat
      361 tgtccttcct attggaaggc gaaaccaatg ttttggctaa tctttccaac gccagtgctc
      421 tcataaaatc acgttttcct aataccgtat ttgcaggctt ttatttgttc gatggaaagg
      481 aattggtttt aggccccttc caaggaggtg tttcctgcat ccgtattgca ctaggcaagg
      541 gtgtttgtgg tgaggcagct cactttcagg aaactgttat tgttggagat gtgacgacct
      601 atctcaacta tatttcttgt gatagtctag ctaaaagtga aattgtggtg ccgatgatga
      661 agaatggtca gttacttgga gttctggatc tggattcttc agagattgag gattacgatg
      721 ctatggatcg agattatttg gaacaatttg tcgctatttt gcttgaaaag acaacatggg
      781 actttacgat gtttgaggaa aaatcttaat gtatcaagca ctttatcgaa aatatagaag
      841 tcaaaacttc tcccagttag ttggtcaaga agttgtggct aagactctta aacaagcggt
      901 ggagcaagag aaaataagtc acgcttatct tttttctggt cctcgtggaa cgggaaaaac
      961 cagtgttgct aaaatctttg ccaaggctat gaactgtccc aatcaagtgg gtggcgaacc
     1021 ttgcaataac tgctatattt gtcaagcagt gacggacggt agtttagaag atgtcattga
     1081 aatggatgca gcttctaata atggggtaga tgaaattcgc gaaattcgtg ataaatctac
     1141 ctatgcgcct agccttgctc gttataaggt ttatatcata gatgaggttc acatgctgtc
     1201 tacaggggct tttaatgccc tcctaaagac gctggaagaa ccaacacaga atgtagtctt
     1261 tattttggcc actactgaat tgcacaagat tcctgctact attctatccc gtgtgcaacg
     1321 ttttgagttt aaatcaatta agacacagga tattaaggaa catattcact atatcttaga
     1381 aaaagaaaat atcagttctg aaccagaggc tgtggaaatc attgccagac gggcggaagg
     1441 tggaatgcgg gacgccttgt ctattttgga tcaagccctg agtttgacac agggaaatga
     1501 gctgacgact gctatctctg aagaaattac tggcaccatt agcctatcag ccttggatga
     1561 ttatgtggcg gccttgtctc aacaggatgt tcccaaagct ttgtcttgct tgaatcttct
     1621 ttttgacaat ggtaagagca tgactcgttt tgtgaccgat cttttgcact atttaagaga
     1681 cttgttaatt gttcaaacag ggggagaaaa tactcatcat agttcagtct ttgtagaaaa
     1741 tttggcactt cctcaaaaaa atctgtttga aatgattcgc ttagcaacag tgagtttagc
     1801 agatattaag tctagtttgc agcccaagat ttatgctgaa atgatgaccg tccgtttggc
     1861 ggaaatcaag cccgaaccag ctctatcagg agcggttgaa aatgaaattg ctacgctgag
     1921 acaggaagtt gcccgtctca aacaagagct ttctaatgta ggtgcggttc ctaaacaagt
     1981 tgcaccagct cctagtcgac cagctacggg caaaacagtc tatcgtgtcg atcgcaataa
     2041 agtgcaatct atcttacaag aggccgtcga aaatcctgat ttagcacgtc aaaatctaat
     2101 tcgtttgcag aatgcctggg gagaggtaat tgaaagtcta ggtgggccgg acaaggctct
     2161 gctagttggt tctcaaccgg ttgctgccaa tgaacaccat gctattcttg cttttgagtc
     2221 taacttcaat gctggtcaaa ctatgaaacg agacaatctc aataccatgt ttggtaatat
     2281 cctcagtcag gcggcaggtt tttcacctga gattttagct atttccatgg aggaatggaa
     2341 agaagttcgc gcagcctttt cagccaaagc caaatcttct caaactgaaa aggaagtaga
     2401 agaaagcctg attccagaag gatttgaatt tttggctgat aaagtgaagg tagaggaaga
     2461 ctaaagaaag atttcatgat acaataagtt tatgaataaa caacaattta ttattatggc
     2521 gctgtttaca gctgctgaga cctatttttt caatgaagcc tggatgactg gccgctatat
     2581 tatggcagcc ttttgggcaa ttttactctt tagaaatttc cgagtcagtt atgtgatggg
     2641 caaaatcgtt gatgtcatcg atcagcattt taataggaaa gactagccct cagcttccag
     2701 acaaaatcaa agccttttag gctttttttt gttatactag aaaagtatat ttatagaatt
     2761 tttgctctat ttctggggaa atcagacgtt tttctagtaa gtactgtaaa agttttgaaa
     2821 aagaaaggaa ctatcatgtc agtattagag atcaaagatc ttcacgttga gattgaagga
     2881 aaagaaattt taaaaggggt taacctgacc ctgaaaacag gagaaattgc cgctatcatg
     2941 ggaccaaatg gtacaggtaa atcgactctt tctgccgcta tcatgggaaa tccaaactat
     3001 gaagtaacta aaggtgaagt tttgtttgat ggcgtaaaca tccttgagtt ggaagtggat
     3061 gagcgtgcgc gtatgggact tttccttgct atgcaatacc catcagaaat ccctggaatt
     3121 accaatgctg agtttcttcg tgccgctatg aatgcgggta aagaagatga tgagaagatt
     3181 tcagttcgtg agtttattac taagctagat gaaaaaatgg aattgctcaa catgaaagaa
     3241 gaaatggcag agcgttacct caacgaaggc ttctctggtg gtgagaaaaa acgcaatgaa
     3301 attcttcaac ttttgatgtt ggagccaaca tttgctcttt tggacgagat tgactcaggt
     3361 cttgatattg acgctcttaa agttgtgtct aaaggtgtca atgccatgcg tggtgaaggt
     3421 tttggtgcta tgatcatcac tcactaccaa cgtcttttga actatatcac acctgatgtg
     3481 gtacacgtga tgatggaagg tcgtgttgtc ctttctggtg gtccagaatt ggctgcgcgt
     3541 ttggaacgtg aaggatacgc aaaattagct gaagaacttg gctacgacta caaggaagaa
     3601 ttgtaatttc ctcgtatctt ttaggagaag taaatgacta gagaaaatat taaacttttt
     3661 tcagaaatgc acgctgaacc aagctggttg gctgatctcc gtcaaaaagc ttttgacaag
     3721 attgagactt tggaattacc agttattgag cgtgtcaaat tccaccgttg gaatctgggt
     3781 gatggaacga ttacagaaaa tgagccatca gcaaatgttc cagatttcac agctttagat
     3841 catcacttga agttggtgca agtaggaact caaactgttt tcgaacaaac tccagttgag
     3901 ttagctgaac agggtgttgt cttcacagac tttcactcag ctttagaaga aattccagag
     3961 ctgatcgaag aattcttcat gtcatctgtt aagtatgatg atgacaagtt ggcggcttac
     4021 cacacagctt actttaacag tggtgctgta ctctatattc cagataacgt agaaatcaca
     4081 gagccaattg aaggaatttt ctaccaagat agcgatagca atgtgccgtt taacaagcat
     4141 attatgatta tcgctggtaa aaattctaag attagttatc tggagcgttt agagtcacgc
     4201 ggtgaaggaa gtgacaaagt aactgccaat atcacagtgg aagtgattgc acgttctggt
     4261 gcgcaagtca agtttgctgc tatcgaccgt ctaggtgaaa acgtcactgc ctacattagc
     4321 cgtcgtggta aattaggcaa cgatgcaagt attgactggg ctatcggtgt catgaacgaa
     4381 ggaaatgtcg ttgctgattt tgatagtgac ttgattggta atggtagcca tgctgacctc
     4441 aaggttgtag ctctttcaag tggtcgtcag gtacaaggga ttgatactcg tgtaactaac
     4501 tatggctgca actctatcgg aaatatccta caacatgggg ttatccttga aaaagcaact
     4561 ttgactttca atggtatcgg ccacatcatc aagggtgcta agggagcaga tgcgcaacaa
     4621 gagagccgtg ttctcatgct ttcagaccaa gcgcgttcag atgctaaccc aattcttttg
     4681 attgatgaaa atgatgtcac tgcaggacac gcagcgtcta tcggacaagt tgatccagaa
     4741 gacatgtatt acctcatgag tcgtggattg gataaggcaa ctgcagagcg tttggttgtt
     4801 cgtggtttcc ttggatctgt tatcgtggag attccagtca aggaagttcg tgatgaaatg
     4861 attgcaacta tcgaagagaa attgtcaaaa cgctaagggg aagcctatgt tagatgtaga
     4921 agcgattcgc aaggattttc caattttaga tcagattgtc aatgatgaac ctctggtcta
     4981 tctggacaat gctgcgacga cacaaaaacc actagtagtt ctgaaagcta ttaacagtta
     5041 ctatgagcag gacaatgcca atgttcaccg tggtgtccat accttagcgg aacgagcgac
     5101 agcttcttat gaagctgctc gtgaaaccat tcgtaagttt attaatgcag gctctacaaa
     5161 ggaagttctc tttaccagag gaacgacaac cagccttaac tgggtggcac gctttgctga
     5221 ggaaattctc actgagggag accaggtctt gatttcagta atggaacacc attctaatat
     5281 cattccatgg caggaagctt gtcgaaagac tggagcagag cttgtctatg tctatcttaa
     5341 agacggtgcc ttggatatgg aggatttgcg agctaaattg actgataagg ttaaatttgt
     5401 ttccctagct catgcctcca atgttcttgg tgtggtcaat ccgatcaagg aaatcactca
     5461 attagcccac caagttgggg caatcatggt agtggatggt gctcaatcta cacctcatat
     5521 gaagattgat gtccaggact tggatctgga ctttttcgcc ttttcgggtc acaagatggc
     5581 tggtccgact ggtatcggtg tcctttacgg caaagaaaag tatcttgagc aaatgtctcc
     5641 agtagaattt ggcggcgaga tgattgattt tgtctacgag caatccgcta gttggaagga
     5701 attgccttgg aaatttgagg ctggaacgcc aaatatggca ggagctattg gacttgcgac
     5761 tgcagttgat tatctggaaa agattggtat ggatgccgtt gaagctcatg aacaggaatt
     5821 gattgcgtac gtctatccaa aactgcaggc aattgaggga ttgaccattt acggttctca
     5881 ggatttggct caacgttcgg gtgttattgc ctttaaccta ggtgatctcc atcctcacga
     5941 tcttgcgacg gctctggatt atgaaggagt ggctgttcgt gctggtcacc attgtgcgca
     6001 acccttgctt cagtatttgg aagtcccagc attagctcgt gcaagttttt atatctacaa
     6061 taccaaggca gattgcgaca aactagtcga tgccctacaa aagacaaagg agtttttcaa
     6121 tggcactttc taaactagat agcctttata tggcagtggt agcagaccat tcgaaaaatc
     6181 cacatcacca agggaagtta gaagatgctg ggcaaatcag tctcaacaat ccgacttgtg
     6241 gggatgtcat caacctctct gtcaagtttg atgcagagga ccgtttggaa gatattgctt
     6301 ttctaaattc aggatgcacg atttcaactg cttctgctag tatgatgaca gatgtcgttt
     6361 taggaaaaac caaacaagaa attttagaac tggcgactat tttttctgaa atggttcaag
     6421 ggcaaaaaga tgagcgtcaa ggccaacttg gagacgcggc attcttgtca ggtgttgcca
     6481 aattccctca aagaatcaag tgtgcaaccc tagcttggaa tgcccttaag aaaacaattg
     6541 aaaatcaaga aaaacagtaa gacaagtttc ttttgtctta tgaattatta gaaatgaaga
     6601 aagaaaggat actatggctg aagaaagagt agaaccaaaa ccaattgacc ttggtgaata
     6661 taaatttggt ttccatgacg atgtagagcc tgtcttatcg acaggaaaag gactcaacga
     6721 aggtgttatt cgtgaattat ctgctgctaa gggtgagcct gagtggatgt tggagttccg
     6781 tttgaagtct tatgaaacct tcaaaaaaat gcccatgcaa acttggggag cagacttgtc
     6841 agagattgac tttgatgact taatctacta ccaaaaacca tctgacaaac cagcccgttc
     6901 ttgggatgat gtacctgaaa agattaaaga aacctttgaa cgtatcggga ttccagaagc
     6961 tgaacgtgct tatttagcag gggcttctgc ccagtacgag tcagaagtgg tttaccacaa
     7021 catgaaggaa gagttccaaa aattaggtat tatctttaca gatacagatt ccgcactcaa
     7081 ggaataccca gacttattta aacaatactt tgcgaagttg gtaccgccga cagataacaa
     7141 gttggcagcc ctcaactcag cagtatggtc gggtggaact tttatctacg tgccaaaagg
     7201 tgtcaaggta gatattccac ttcaaactta tttccgtatc aataacgaaa atataggtca
     7261 gttcgaacgt accttgatta tcgttgatga gggagcaagc gtccactacg tagaaggatg
     7321 tacagcacca acatattcaa gcaatagctt acacgctgcc attgtagaaa tttttgcttt
     7381 ggacggagct tatatgcgtt atacaactat ccaaaactgg tctgataacg tctataactt
     7441 ggtaacaaag cgtgctaagg ctcaaaagga tgccactgtt gagtggattg atggaaactt
     7501 gggtgccaaa acgactatga aatatccatc tgtttacctt gatggagaag gagcgcgtgg
     7561 taccatgctc tctatcgcct ttgctaatgc agggcaacac caagacacgg gtgctaagat
     7621 gattcacaat gctccacata ccagctcgtc tattgtgtct aaatccatcg ctaaaggtgg
     7681 aggaaaggtt gactaccgtg gacaagtcac ctttaacaag aactctaaga aatctgtttc
     7741 ccacattgaa tgtgatacca ttatcatgga tgacttgtca gcatcagata ctattccatt
     7801 taatgaaatt cacaactcgc aagtggcttt ggaacacgaa gccaaagtat ctaagatttc
     7861 agaagagcaa ttgtattatc tcatgagccg tggattgtca gaatctgagg caactgaaat
     7921 gattgtcatg ggatttgtag aaccctttac aaaagaactt ccaatggaat acgcagttga
     7981 gctgaaccgc ttgattagct atgaaatgga gggatcagtt ggataaaatt tgattttata
     8041 ctcttcgaaa atctcttcaa accacgtcag catcgcctta ccgtatgtat ggttactgac
     8101 ttcgtcagtt tcatctacaa cctcaaaaca gtgttttgag caacctgagg ctagcttcct
     8161 agtttgttct ttgattttga gtattagatt tactcaaaat caaggatttt gaagatgaac
     8221 ttgtatcaaa aaatcgcggt ttaaaatcgc gattttttat aatttctcgt taacaaagcg
     8281 gacaaactga ttccaccaaa cttttaagaa gaaggctttt tcaattttct tgtctgctac
     8341 catttcgaaa ctagggcgct ctgtggtgat gtaaccttga ccaatcaagt ccttgtcttc
     8401 ataagtcaaa tggccaacca ctgttccagc ttcaagtggt gctgggattg ctttggaatc
     8461 aggtgtgaat tgaacagatt gggaagattg attcccaaca cgttcgatta gatagatatc
     8521 ctctggagcc actgcagtta ctgtatcttc ttttccatct tgtacagggg ctttgctatc
     8581 ttgataggca tcgccttgtt gaacgatttt gcgaagtgta aatgtagaag aaatataatc
     8641 cattagggaa gatgtagctg taaatcgagc gtaaggatta ttgtcttgat gatctgcatt
     8701 taaaacaact gtgatgactc tcatgccttt ttcgacagta gtaccaacaa aagactctcc
     8761 agccttatct gttgttcctg tttttagccc atcaaaacca ccacggtaag caggcatacc
     8821 ttctaacatg tagttggttg aagtgattgt catcctagca aaagtagaag aaggtttttt
     8881 ggtgatttct aagacttgtg ggtatttttt gatgaggttg cgagcaacga tagcgacatc
     8941 ataagcacta agcttatttt cctcatcttt tttagaacct gggtaaatgt tatcccctag
     9001 agtttcattg ttaagacctg tcgtattgac aacagtggca tcctgaattc cccattccaa
     9061 gagttttgcc cgcatcatat cgacgaaatc tttttctgag ccagcaattt tctcagctag
     9121 ggcaatagcg gcgctgttgg cactagatac cagagttgct tcaagcaact cttcgacagt
     9181 ataattacgg gcctccatag gaatattact ggcttcagaa tttgtcgtca attgataagg
     9241 ataatcagaa atatctacag gagtggagag ggtaatactt ccgttttcca aagcttcata
     9301 gaccagataa acagtaatca attttgttat ggaagcaatt tcgacaggtt gcgttgcatc
     9361 cttctcatag agaattttac cagtatttgc ctcaacagca atcgcatgtt tagcggcaat
     9421 ggtaaaatct tgagcaacag cagtagaagc accccctaaa agagagacag ttaacaaagt
     9481 taaaaatatt tttttcatag tagtcttatt ctatcataaa gaaaaaaaat attcttgctt
     9541 taataattca tctgttaagc tttttgaaaa tatggtaaaa taaagtgagg gaggtaactc
     9601 atgtttcgta gaaataaatt atttttttgg accacagaaa ttttactctt aaccatcatc
     9661 ttttacctat ggagacagat ggggtctttg attaaccctt ttgttagcgt gcttaataca
     9721 attatgattc catttttatt agggggcttt ctttattatt tgacaaaccc tattgttact
     9781 ttcttaaata aagtctgtaa actcaatcgt ttgcttggta ttttaattac cttgtgtact
     9841 ttggtctggg gaatggtcat aggtgttgtc tatctcttac ctattttgat taatcagtta
     9901 tctagtttga ttatatctag tcaaactatt tatagtcgag tacaagactt aatcatagac
     9961 ttatctaatt atcctgcgct ccagaatttg gatgtagaag ctacaattca gcagttaaac
    10021 ttatcctatg ttgatattct tcaaaatatc ctaaatagcg tatcaaatag tgtggggagc
    10081 gtcttgtcag ctcttatcag tactgttttg attttgatta tgactccagt ttttttggtt
    10141 tatttcttat tagatggaca taaattcttg cccatgcttg aaagaacgat tctaaagagg
    10201 gatcgcttgc atattgcagg cttattaaag aatttaaatg cgacgattgc tcgctatatt
    10261 agtggagttt cgattgacgc aatcattata ggttgtttag cttatattgg ctatagtatt
    10321 attggtttaa aatatgcttt agtttttgcc attttttctg gtgtagccaa tttaattcct
    10381 tatgtggggc caagtattgg tttgattcct atgatcatcg caaatatatt cactgatccc
    10441 catagactgc tgattgcagt gatttatatg cttgttgttc agcaggtaga tggcaatatc
    10501 ttatatcctc gaatcgtagg aagtgttatg aaggttcatc caatcacgat tttagtttta
    10561 cttttgttgt caagcaatat ttatggtgta gttggaatga ttgtcgcagt gccaacctat
    10621 tctatcttga aagaaatttc taagttctta tcccgtttgt atgaaaatca taaaataatg
    10681 aaagaacgag aaagagaatt agctaagtaa aagtcaggag aaccctgatt tttctttact
    10741 ggaagtggcc tttagattag aagactgaaa ataagttaaa gtcttaaact aattttcaca
    10801 gctaagaata gtagaagtta atctgataaa aatcgaaaaa accagtggaa ttctgtgtca
    10861 gggtaagttc cactggtttt catagtctat taaagttcga atgaaaccta tttatagtag
    10921 attgaaacta gaatagtaca cctctaattc taaaacattg ttagaaatcg atttgactgt
    10981 cctgatctat tcgtcctatt cttatttcat tttactatat tttggtgcaa taagtgaaaa
    11041 gtagtccgaa taatataagg attgatttta tagtttttaa actcaaatga attaaaataa
    11101 agagagtacg aaaattctca tctgaaagta ttttagaata attctcttcg tgaatttctt
    11161 caaaacagat agcttcatct taggtatgtg ttaattggat ttcgtaagct ctatttataa
    11221 tcgtaaagtt atgcactgag aaagttgtag ttagtcttcc agtttgctaa atttctcgaa
    11281 tagtatcttt tttaggtatg tgatttcttt ttgcattttt gagttagata aggtataatg
    11341 gttttattgt cttttggggt cgttacggat tcgacaggca ttatgaggca tattttgcga
    11401 ctcgtgtggc gacgtaaacg ctcagttaaa tataactgca aaaaataaca cttcttacgc
    11461 tctagctgcc taaaaaccag caggcgtgac ccgatttgga ttgctcgtgt tcaatgacag
    11521 gtcttattat tagcgagata cgattaagcc ttgtctagcg gcttgataag agattgatag
    11581 actcgcagtt tctagacttg agttatgtgt cgaggggctg ttaaaataat acataaccta
    11641 tggttgtaga caaatatgtt ggcaggtgtt tggacgtggg ttcgactccc accggctcca
    11701 ttattccttt gcattctttt gcattccttg gtaaaacgtt gttaaatcaa cgttttttat
    11761 ttttatcttt ggtattcctt tgcattcttt tgctaaaaag ggagtcacaa acagacccta
    11821 ttttaaaaaa ggatacaaca tttgttgcat cctaaaaata atcttttttc cacggaagac
    11881 atgggattcg aacccacgca cgctattaca cgcctaccgc gtttccaaca cggcctctta
    11941 agcctcttga gtaatcttcc aatacttact caaatagtct accataaagg ctcttatctt
    12001 gcaataaaaa ttctagaaat aagaaaaaat gatagatttt gaaagaaaat gataaaaaat
    12061 gcttgacttc gaaataaagt atggtagaat gaatagtgta aacgataaca ggaggtgatt
    12121 cagtgttaaa aacagaacgt aaacaactga ttttagagga gttaaatcaa catcatgtag
    12181 tttctctaga aaaattagtt agtttgctag aaacgtcaga atcaacggtt cgaagagact
    12241 tggatgagtt ggaagcggaa aacaagcttc gtcgtgtgca tggtggagca gaactccccc
    12301 actccttaca ggaagaagaa accattcaag aaaaatctgt caaaaacctt caagaaaaga
    12361 agttgctggc tcagaaagca gcctctctca ttaaagaaaa agatgtcatc tttatcgatg
    12421 ctggaacaac aactgctttt ttgattcatg aattggtcaa taagaatgtt acagttgtga
    12481 ccaactccat tcaccatgcc gctcagttgg ttgaaaagca gattccaact gtcatggttg
    12541 gaggaaacgt caagacggcg acagatgcta gtatcggggg cgttgctctt aaccagatta
    12601 accaattgca ctttgaccgt gcctttatcg gaatgaatgg tgttgacgat ggctattata
    12661 cgactcctga tatggaggag ggagctgtga aaagagctat tttggagaat gccaagcaga
    12721 cctacgtctt ggtggattcg tcaaaaattg gacaaacttg ctttgccaag gtagcaccac
    12781 tcaaacgcgc tatcgttatc actagtcaag ggcatgagct cttgcaggtt attaaggaga
    12841 aaacggaggt aatagaagta tgatttatac agtcacactc aatccatcca ttgactatat
    12901 cgttcgtttg gaccaagtca aagttggtag tgtcaatcgt atggacagtg atgataagtt
    12961 tgctggtggg aaaggaatca atgtcagccg tgtcttgaaa cgtttgaata taccaaatac
    13021 agcgacggga tttatcggtg gctttactgg taaatttatc acagatactt tagcagagga
    13081 agaaatcgag acacgttttg tccaggtggc agaagatact cgtatcaatg ttaaaatcaa
    13141 agcagaccaa gaaacagaaa tcaacggaac gggtccaact gttgaatcgg ttcagctaga
    13201 agaattgaaa gctattttat ctagtctgac agcagaagat acagttgtct ttgcaggttc
    13261 aagtgctaaa aatctaggca atgttatcta taaggatttg atttccttga cgcgccagac
    13321 tggtgcgcaa gtggtctgtg actttgaagg acagacctta attgatagtt tggactacca
    13381 gcctcttctt gtaaaaccaa acaatcatga acttggagcg atttttgggg ttaaactcga
    13441 aagtttagat gaaattgaga aatacgctcg tgagttactg gctaagggtg ctcaaaatgt
    13501 tattatctct atggctggtg atggtgccct tcttgtcaca tctgagggag cttacttcgc
    13561 taaaccaatc aaaggaacag tcaaaaattc agttggagct ggtgattcta tggttgctgg
    13621 attcacaggt gaatttgtca aatcaaaaga cgcagtagaa gccttcaaat ggggagtggc
    13681 ttgcggaacg gcaactacct tctcagatga cttggcaacg gcggaattta ttaaagaaac
    13741 atatggaaaa gttgaggtag aaaaacgatg aaaattcaag acctattgag aaaagatgtc
    13801 atgttgctag atttgcaggc aactgaaaaa acagctgtca tcgacgagat gattaaaaat
    13861 ttgacagacc acggttatgt aacagatttt gaaacattta aagaaggaat tttggcgcgt
    13921 gaagctttga cttctactgg tttgggtgat ggaatcgcaa tgcctcacag caaaaacgct
    13981 gctgtcaaag aagcgacagt tctatttgct aagtcaaata agggtgttga ctacgagagc
    14041 ttggatggac aagcaactga cctcttcttc atgattgcag ctccagaagg tgccaatgat
    14101 actcacttgg cagccttggc agaattgtct caatacttga tgaaagacgg ttttgcagac
    14161 aaacttcgtc aagcaacatc tgcagaccaa gttatcgaac tttttgacca agcttcagaa
    14221 aaaactgagg aacttgttca agcacctgct aatgactctg gtgactttat cgtagctgtt
    14281 acagcttgta caacaggtat tgcccacact tacatggccc aagaagccct tcaaaaagta
    14341 gctgctgaaa tgggggttgg tatcaaggtc gaaaccaacg gtgctagcgg tgttggaaat
    14401 caactaactg cagaagatat ccgtaaggct aaagctatta tcattgcagc agacaaggcc
    14461 gttgaaatgg atcgatttga tggaaaacca ttgatcaatc gtccagttgc tgacggtatc
    14521 cgtaagacag aagagctaat taacttggct ctttcaggag atactgaagt ctaccgtgcc
    14581 gctaatggtg caaaagctgc aacagcctct aacgaaaaac aaagccttgg tggtgccttc
    14641 tacaaacact tgatgagtgg tgtatctcaa atgttaccat tcgttatcgg tggtggtatc
    14701 atgattgccc ttgccttctt gattgacggt gctttgagtg ttccaaatga aaaccttggc
    14761 aatcttggtt cttaccatga gttagcttct atgttcatga aaattggtgg agctgccttt
    14821 ggtttgatgc ttccagtctt tgcgggttat gttgcctact ctattgctga aaaaccaggt
    14881 ttggtagcag gtttcgtggc tggtgctatt gccaaagaag gttttgcctt tggtaaaatt
    14941 ccttatgccg caggtggtga agcaacttca actcttgcag gtgtctcatc tggtttccta
    15001 ggtgcccttg ttggtggatt tatcgcaggt gccttggttc ttgccatcaa gaaatacgtt
    15061 aaagttcctc gttcactcga aggtgctaaa tcaatccttc tattgccact tcttggaaca
    15121 atcttgacag gatttgttat gctagctgtg aatatcccaa tggctgcaat caacactgct
    15181 atgaatgact tcctaggtgg tcttggagga ggttcagctg tccttcttgg tatcgtcctt
    15241 ggtggaatga tggctgttga catgggtgga ccagttaata aagcagctta tgtctttggt
    15301 acaggtacgc ttgcagcaac tgtttcttca ggtggttctg tagccatggc agcagttatg
    15361 gctggaggaa tggtgccacc acttgcaatc tttgtcgcaa ctcttctttt caaagataaa
    15421 tttactaagg aagaacgtaa ctctggtttg acaaacatca tcatgggctt gtcatttatc
    15481 actgagggag cgattccatt tggtgccgct gacccagctc gtgcgattcc aagcttcatc
    15541 cttggttcag cagtagcagg tggactcgtt ggtcttactg gtatcaaact catggcgcca
    15601 cacggaggaa tcttcgttat cgcccttact tcaaatgctc tcctttacct cgtttctgtc
    15661 ttggtaggag caatcgtaag tggtgtggtt tatggttacc tacgcaaacc acaagcataa
    15721 aaaatagaaa aatgaaaaga ttggaccgtt tggtgcagtc tttttctctt cccgaaatgc
    15781 ctgtgaaata tggtataata gaagaatggc aaacaagaat acaagtacaa caagacggag
    15841 accgtctaaa gcagaactgg aaagaaaaga agcgattcaa cgaatgttga tttcgttagg
    15901 aattgcgatt ttattgattt tcgcagcctt caaattaggg gctgcaggta taacccttta
    15961 taatttaatt cgcttgctag tgggtagcct agcttatctg gcgatattcg gcctattaat
    16021 ctatctcttc tttttcaagt ggatacgaaa acaggaagga ctcttatctg gttttttcac
    16081 catatttgct ggcttactct tgatttttga ggcctacttg gtttggaaat atggtttgga
    16141 caagtccgtt ctaaaaggga ccatggctca ggttgtgaca gatctgactg gttttcgaac
    16201 gactagcttt gctggagggg gcttgatcgg ggtcgctctt tatattccaa cagcctttct
    16261 cttttcaaat atcggaactt actttattgg ttctatcttg attttagtgg gttctctcct
    16321 agtcagccct tggtctgttt acgatattgc tgaatttttc agtagaggct ttgccaaatg
    16381 gtgggaaggg cacgagcgtc gaaaagagga acgctttgtc aaacaagaag aaaaagctcg
    16441 ccaaaaggct gagaaagagg ctagattaga acaagaagag actgaaaaag ccttactcga
    16501 tttgcctcct gttgatatgg aaacgggtga aattctgaca gaggaagctg ttcaaaatct
    16561 tccacctatt ccagaagaaa agtgggtgga accagaaatc atcctgcctc aagctgaact
    16621 taaattccct gaacaggaag atgactcaga tgacgaagat gttcaggtcg atttttcagc
    16681 caaagaagcc cttgaataca aacttccaag cttacaactc tttgcaccag ataaaccaaa
    16741 agatcagtct aaagagaaga aaattgtcag agaaaatatc aaaatcttag aagcaacctt
    16801 tgctagcttt ggtattaagg taacagttga acgggccgaa attgggccat cagtgaccaa
    16861 gtatgaagtc aagccggctg ttggtgtaag ggtcaaccgc atttccaatc tatcagatga
    16921 cctcgctcta gccttggctg ccaaagatgt ccggattgaa gcaccaatcc ctgggaaatc
    16981 cctaatcgga attgaagtgc ccaactccga tattgccact gtatctttcc gagaactatg
    17041 ggaacaatcg caaacgaaag cagaaaattt cttggaaatt cctttaggga aggctgttaa
    17101 tggaaccgca agagcttttg acctttctaa aatgccccac ttgctagttg caggttcaac
    17161 gggttcaggg aagtcagtag cagttaacgg cattattgct agcattctca tgaaggcgag
    17221 accagatcaa gttaaattta tgatggtcga tcccaagatg gttgagttat ctgtttacaa
    17281 tgatattccc cacctcttga ttccagtcgt gaccaatcca cgtaaagcca gcaaggctct
    17341 gcaaaaggtt gtggatgaaa tggaaaaccg ttatgaactc tttgccaagg tgggagttcg
    17401 gaatattgca ggttttaatg ccaaggtaga agagttcaat tcccagtctg agtacaagca
    17461 aattccgcta ccattcattg tcgtgattgt ggatgagttg gctgacctca tgatggtggc
    17521 cagcaaggaa gtggaagatg ctatcatccg tcttgggcag aaggcgcgtg ctgcaggtat
    17581 ccacatgatt cttgcaactc agcgtccatc tgttgatgtc atctctggtt tgattaaggc
    17641 caatgttcca tctcgtgtag catttgcggt ttcatcagga acagactccc gtacgatttt
    17701 ggatgaaaat ggagcagaaa aacttcttgg tcgaggagac atgctcttta aaccgattga
    17761 tgaaaatcat ccagttcgtc tccaaggctc ctttatctcg gatgacgatg ttgagcgcat
    17821 tgtgaacttc atcaaggctc aggcagatgc agactacgat gagagttttg atccaggtga
    17881 ggtttctgaa aatgaaggag aattttcgga tggagatgct ggtggtgatc cactttttga
    17941 agaagctaag tctttggtta tcgaaacaca gaaagccagt gcgtctatga ttcagcgtcg
    18001 tttatcagtt ggatttaacc gtgcgacccg tctcatggaa gaactggaga tagcaggtgt
    18061 catcggtcca gctgaaggta ccaaacctcg aaaagtgtta caacaataaa aaaatagctt
    18121 ctttccgagt ttggagggaa gctattttag tggctattga ttgcttttat tttctgaagt
    18181 tggcgcattg gactgttttt cgttttcagt agcaggttta cttgaagcag gagtagaaga
    18241 gtcctgagtt gctgttttct gatcttcttt tttctcttcc ttgacgctag attttggtgt
    18301 ttcctcttgc tgtgtttttt cttgactagt gttagtctct ttagttggac tggtgttttc
    18361 cttaggggat tccttttgga tttctttgac aatggttgtc gtctggcttg tcgtaggttc
    18421 ttttttaata tttttgttat tatccaaggc gttcataatc gtgatacttg cggtaatcaa
    18481 gccaaggata ctagcgattg tagcaacggt tttttgaaag actgtaaagc cttttttgat
    18541 gtgttctgtt tttggttttg aagttctacg atagttagac atacattctc tcctttgatt
    18601 atgatttatt atactctgtt tctttaaaaa aatcttaaaa aaagagaaat tgccctttct
    18661 tgtcgcaagc tccgtttcat gatacaatag aggaagtgat tttagaaagc gtgagaaaca
    18721 tgatttactt tgataattca gcgacgacca agccttatcc tgaagccctt gaaacctata
    18781 tgcaggtcgc ttcaaaaatt ttaggaaacc catctagtct ccatagtttg ggagaccaag
    18841 caacacgaat cttagatgct tctcgccaac agattgcaga tttaatcggt aagaaaagcg
    18901 atgaaatctt ctttacctct ggtggaacag aaggggataa ctgggttatc aagggtgtgg
    18961 cctttgaaaa agctcagttt ggcaagcaca tcattgtttc agccattgaa catccagcag
    19021 tcaaagagtc agccctctgg ttgaaaagtc aaggatttga agtggatttt gctccagttg
    19081 ataagaaagg cttggtcgat gttgaggcgt tagcaggttt gatacggcct gatacaatcc
    19141 tcgtttctat catggctgtg aacaatgaaa tcggctctat ccaacctatt gaggctattt
    19201 cagaattctt ggcagacaag ccgactattt ccttccacgt tgatggggtt caggcgctta
    19261 ccaagattcc gactgaaaag tatctgacag aacgagtgga ttttgcgact ttctctagtc
    19321 acaagttcca cggggttcga ggtgttggct ttgtctatat caaatctggc aagaagatta
    19381 cacctcttct tacaggtggt ggccaggagc gagattatcg ttcgacaact gaaaatgtgg
    19441 cagggattgc agcgacagcc aaggccctcc gtttgtctat ggaaaagcta gatatcttta
    19501 ggagcaagac tgggcagatg aaggcagtga ttcgccaagc tcttctgaac catccggata
    19561 tttttgtctt ttcagatgag gaaaactttg cacctcatat tctgactttt ggaatcaaag
    19621 gtgttcgagg tgaagtcatc gttcacgcct ttgaagacta tgatattttc atctcaacaa
    19681 cctcagcttg ttcatctaag gcaggaaaac cagccggtac cttgattgcc atgggagtgg
    19741 acaaagataa ggccaagtca gctgtgcgtc ttagcctaga cttggaaaat gatatgagtc
    19801 aggtcgagca gtttttgacc aagttaaaat tgatttacaa tcaaactaga aaagtaagat
    19861 aggagcattc atgcagtatt cagaaattat gattcgctac ggagagttgt caaccaaggg
    19921 taaaaaccgt atgcgtttca tcaataaact tcgtaataat atttcggacg ttttgtctat
    19981 ctatacccaa gttaaggtaa cagcagatcg cgaccgtgcc cacgcttacc tcaatggagc
    20041 tgattacaca gcagttgcag aatctctcaa acaagttttt ggaattcaaa acttttctcc
    20101 tgtttataag gttgaaaaat ctgtagaagt tttgaagtct tctgtccaag agattatgcg
    20161 ggacatctac aaggaaggta tgacctttaa gatttctagc aagcgtagcg accacaactt
    20221 tgaacttgat agtcgtgaac tcaaccaaac acttggaggg gctgtattcg aagccattcc
    20281 aaatgtgcaa gttcaaatga aaagtcctga catcaatctt caggtggaga ttcgtgaaga
    20341 agcagcctat ctttcttatg aaaccattcg tggggctggt ggtttgccag ttggaacttc
    20401 aggtaaaggg atgctcatgt tgtcaggagg gattgactca cctgtagcag gttatcttgc
    20461 tcttaagcgt ggggtggata tcgaggcagt tcactttgct agtccaccat atactagtcc
    20521 tggtgccctc aagaaagcgc aggacttgac ccgtaaattg accaagtttg gcggaaatat
    20581 ccagtttatc gaggtgcctt tcacagagat tcaagaggaa atcaaagcca aagcgccaga
    20641 agcttatttg atgactctaa ctcgtcgctt tatgatgcgg attactgacc gtattcgtga
    20701 ggtacgaaat ggtttggtta tcatcaatgg ggaaagtcta ggtcaagtag ccagccaaac
    20761 ccttgaaagt atgaaggcta tcaatgctgt taccaacact cccatcattc gtcctgtggt
    20821 taccatggac aagttggaaa tcattgacat cgcccaggaa atcgatacct ttgacatttc
    20881 aatccaaccg tttgaagact gttgtaccat ttttgcacca gatcgtccaa aaacaaatcc
    20941 taaaattaag aatgcggagc agtacgaagc gcgtatggat gttgaaggct tggttgagcg
    21001 agcagtggct ggaatcatga ttactgaaat cacacctcaa gccgaaaaag atgaagttga
    21061 tgacttgatt gacaatctgc tctaattcag aaaatccaaa agaatagcga aaatcagtaa
    21121 aaaaagttag ttttttctct aaaaacaggt aaaaaactaa ctttttttat ttttatgata
    21181 taatgatata aaattttgaa tatagagagt tttctgacaa tgaatcaatc ctacttttat
    21241 ctaaaaatga aagaacacaa actcaaggtt ccttatacag gtaaggagcg ccgtgtacgt
    21301 attcttcttc ctaaagatta tgagaaagat acagaccgtt cctatcctgt tgtatacttt
    21361 catgacgggc aaaatgtttt taatagcaaa gagtctttca ttggacattc atggaagatt
    21421 atcccagcta tcaaacgaaa tccggatatc agtcgcatga ttgtcgttgc tattgacaat
    21481 gatggtatgg ggcggatgaa tgagtatgcg gcttggaagt tccaagaatc tcctatccca
    21541 gggcagcagt ttggtggtaa gggtgtggag tatgctgagt ttgtcatgga ggtggtcaag
    21601 ccttttatcg atgagaccta tcgtacaaaa gcagactgcc agcatacggc tatgattggt
    21661 tcctcactag gaggcaatat tacccagttt atcggtttgg aataccaaga caaaattggt
    21721 tgcttgggcg ttttttcatc tgcaaactgg ctccaccaac cgctatatcg agtgccagaa
    21781 actatcgcct gaccaacgca tcttcatcta tgtaggaaca gaagaagcag atgatacaga
    21841 caagaccttg atggatggca atatcaaaca agcctatatc gactcgtcgc tttgctatta
    21901 ccatgatttg atagcagggg gagtacatct ggataatctt gtgctaaaag ttcagtctgg
    21961 tgccatccat agtgaaatcc cttggtcaga aaatctacca gattgtctga gattttttgc
    22021 agaaaaatgg taagttaaga aaggaaaaaa cgaaatgcat attgaacatc ttagccactg
    22081 gagtggtcat cctaaccgtg aaatgtacct taaccgttat ggacatggtg ggattccagt
    22141 tgtggtcttt gcttcatcag gtggtagtca caacgaatac tatgattttg gcatgattga
    22201 tgcctgtgct tcctttatcg aggaaggccg tgtccagttc tttaccctat ctagtgtgga
    22261 tagtgagagc tggttggcta cttggaaaaa tgctcatgac caagcggaaa tgcaccgtgc
    22321 ctacgaacgt tatgtgattg aggaggccat tcttttatca agcacaagac aggttagttg
    22381 gatggcatga tgacgacagg ttgctctatg ggagcctatc atgcactcaa tttcttcctc
    22441 cagcatccag atgtctttac caaagtgatt gctctcagtg gtgtttacga cgcacgtttc
    22501 tttgtcggtg attactacaa cgatgatgct atttaccaaa actcgccagt agattatatt
    22561 tggaaccaaa acgatggctg gtttattgac cgttaccgtc aggcagagat tgtgctgtgt
    22621 acggggcttg gagcctggga acaagatggt ttaccatcct tttacaagct caaagaagcc
    22681 tttgaccaga aacaaattcc agcctggttt gctgaatggg gacatgatgt cgcccacgac
    22741 tgggaatggt ggcgtaaaca aatgccttat ttcctcggta atctctattt ataaaaggag
    22801 ttacctatga attaccttgt tatttctccc tactatccac aaaactttca acagtttacc
    22861 atcgaactag ctaataaagg catcacagtc ttgggaattg gtcaagagtc ttacgagcaa
    22921 ttggatgagc ccttgcgcaa tagcttgacc gagtattttc gtgttgataa tcttgagaac
    22981 atagatgaag tcaaacgtgc agttgctttt ctcttttata aacatggtcc aattgaccgc
    23041 atcgagtctc acaatgaata ctggcttgag ctagacgcaa cactcagaga acaattcaat
    23101 gtttttggtg ccaaaccaga ggatctcaaa aagacgaaat ataagtctga aatgaagaaa
    23161 cttttcaaaa aagcaggtgt tcctgtggta cctggagctg ttatcaagac ggaagcagat
    23221 gttgatcaag cagtgaaaga aatcggtctt ccaatgattg ccaaacctga taatggagtg
    23281 ggagcagccg caacctttaa acttgagaca gaagacgata tcaatcactt caagcaagaa
    23341 tgggaccatt caacccttta tttctttgaa aaatttgtca cttccagcga aatctgtacc
    23401 tttgacgggc tcgtggacaa ggatggaaag attgtcttct caacaacctt tgactacgcc
    23461 tatacaccgc ttgacctcat gatttataag atggacaatt cttattatgt gctcaaggat
    23521 atggatccta aactgcgcaa gtatggggaa gcaattgtca aagaatttgg tatgaaagaa
    23581 cggtttttcc atattgagtt cttccgtgag ggggacgatt atattaccat cgagtacaat
    23641 aaccgccctg caggtggttt taccattgat gtttataact ttgctcattc cttggacctt
    23701 tatcgtggct atgcagctat tgtcgcagga gaggagttcc cggcgtcaga ctttgaaact
    23761 cagtattgtt tggctacttc tcgccgtgca aatgctcact atgtttattc agaagaggat
    23821 ttgcttgcca aatatagcca gcagttcaag gttaaaaaag tcatgccagc tgccttcgcg
    23881 gaacttcaag gagattacct gtatatgctg acaactccga gtcgacaaga aatggatcag
    23941 atgattgctg atttcggaca acgtcaagaa taagaactat cggattaagg aaattcactc
    24001 ccttaatcct tttgttttgt ctggtaaaaa ataagagcat cttaacaagg tagctatcat
    24061 aaaacttgtt cgataactat ttgaagcagg attaggtggc tagaaattga attttaacat
    24121 ttcaatttag tcatagtatt gtgttttcgt atccttaaat cagctaaaag gatccatgac
    24181 gacacctata cgatatagtt ttcaggatac caaaccagtc tattaatact caatgaaaat
    24241 caaagagcaa actaggaagc tagccgcagg ttgctcaaaa cactgttttg aggttgtgga
    24301 tagaactgac agagtcagta tcatatacct acggcaaggt gaagctgacg tggtttgaag
    24361 agattttcga agagtataaa atattcaggt gacgcataga tatagttaat tgaagctttg
    24421 tttgaaatct gataaaataa tgatattact aagttttaaa aactaaagaa aagggaagat
    24481 atgattacag gcgaattaaa aaataaaatc gaccagctgt gggaaattct ttggacagaa
    24541 ggaaacgcaa atcctttaac aaatattgaa cagttgactt atctcttatt tatgaaagat
    24601 ttggatagtg tcgagcttgg acgtgaaagt gatgctgaat ttctagggat tccttatgag
    24661 ggagtttttc caaaagataa acctgaatac cgttggtcaa cttttaaaaa tataggagat
    24721 gctcaggaag tttatcgttt aatgactcag gagatttttc cgtttattaa aaatctcaag
    24781 ggggatacag atgatacagc cttttcacga tatatgcgag aagctatttt tcaaataaat
    24841 aaacctgcta cgcttcaaaa ggcaatttct atcttagatg tttttccaac taggggatta
    24901 gatgtagatt ttgataatga caaacaaagt attactgata tcggagatat ctatgaatat
    24961 ctgttatcaa aattgtcgac cgcaggtaaa aatggacagt tccgtacacc tcgtcacatc
    25021 atcgatatga tggttgagtt gatgcaaccg actatcaaag atatcatctc agatcccgct
    25081 atgggttctg ctggcttctt agtatctgct agccgttact taaagcgtaa gaaagatgaa
    25141 tgggaaacca atacagataa tatcaatcat tttcataatc agatgtttcg tggaaatgat
    25201 acggatacga ctatgttgag acttggggcg atgaacatga tgctacatgg agtagaaaat
    25261 ccacaaatca gttaccttga ctcgctgtct caagataatg aagaagccga taaatatact
    25321 ttggttttag caaatcctcc ttttaagggc tcacttgact acaattcaac ctctaatgac
    25381 cttcttgcaa ccgtaaaaac caaaaaaaca gaattactct ttctttctct tttcttgcga
    25441 actttaaaac caggtggacg agcagcagtt atcgtacctg atggtgtcct ttttggttcg
    25501 tctaaagctc ataaaggaat tcgtcaggaa attgtagaga atcataagct tgatgctgta
    25561 atctcaatgc ctagtggtgt gttcaagcct tatgctggag tttcaactgc cattctcatc
    25621 tttacaaaaa ctggtaatgg tggtactgac aaagtctggt tttacgatat gaaagcggat
    25681 ggtttaagtt tggatgataa gcgacaaccg attagcgaca atgatattcc agatattatc
    25741 gaacgctttc atcatcttga aaaagaagca gaacgtcaga gaacggatca atctttcttt
    25801 gttccagttg ctgagataaa ggaaaatgat tatgatttgt ctatcaataa atataaagag
    25861 attgagtatg aaaaagttga gtatgaacca acagaagtca tattaaagaa aatcaatgat
    25921 ttagaaaaag aaattcaagc tggcttggct gaattggaaa aattactcaa gtagggaggt
    25981 ggctgtatga aaaaagtgaa gttgggggaa gtttgtgaga ttttatctgg ttacgctttt
    26041 aaatcatcac aatttaatga taacaaaatt ggtctcccct taatacgaat tcgagatgta
    26101 gaaagaggtt tttctgatac ctactttgaa ggaacttatc ccgaagaata tcttattaaa
    26161 aatggagact tattgattac aatggatggc agttttatat tgaaaaaatg ggagggggat
    26221 ttagcgctac ttaatcaacg tgtctgtaaa attaaaatta cggataaaag tgtagatgaa
    26281 ggttatatat cttggttgat tcctaaattt ttaaaagaaa ttgaagataa gacccctttt
    26341 gttacagtga aacatctttc agtagctaaa ataaaagata tctcatttgt attgcctaat
    26401 aaactagaac aaaagctaat tgcaaaaaaa ctaaatacga taagtcaaat ttatgatttt
    26461 cgtaaaattc aatcagaaaa atttaacgag ctcgtcaaat cccgatttaa cgagatgttt
    26521 ggggaaaata aaatatttga aagcattgat aacttatttg atattataga tggtgatagg
    26581 ggcaaaaatt atcctaaatc agatgagttg tttagtgagg agtactgttt atttttaaat
    26641 acaaagaatg ttactaaaaa cggattttca ttcgatacaa agcaatttat cactaaaaca
    26701 aaggataaat tacttcgaaa aggcaaactt gagcgttatg atatagtctt gacaacaaga
    26761 ggtactgttg gaaatgtagc gtactacgat gaattaataa aatataaaca tttacgtata
    26821 aattcaggta tggtaatatt acgtcccaag acaccaaatc taaatcagaa atttattatc
    26881 catgttttaa ggaataataa ttatagtcga gtgatatcag gaagtgctca gcctcagtta
    26941 ccaattacaa aattaaaaaa aatacttctc cccctccccc cactagccct ccaaaatgag
    27001 ttcgcagact ttgtagtcca ggtcgacaaa tcacaattgg caatccaaaa atctctggaa
    27061 gaacttgaaa ctttgaagaa atctctgatg caggagtatt ttggctgata ttctgccatt
    27121 gtaattacgg taatgatttg ttataatact tcaaaggagg aaatcagatg gtagtaaaaa
    27181 caagaaaaca aggaaattca atcaccatta cgattccaag tgaatttaat attccaagtg
    27241 gtgttaaata cgaagcgaaa ttgttaccaa gtggtgagat tatctttact cctgaagaat
    27301 tggggcagca ggtttcttat gtatctgatg atgcctttga cttaaattta gataaaatat
    27361 ttgacgaata cgacgatgtt ttcaaagctt tggtggaaaa atgacaatct atctgacaga
    27421 aaagcaaatt gaaaaaataa atgctttagc aattcaacgg tattctccaa atgagaaaat
    27481 tcaaacagtt agttcttctg ccttaaatat gattgtgaac ttaccagaac aatttgtctt
    27541 tgggaagtct ctttatccaa caatttttga taaagcaacg atactatttg tccaattgat
    27601 aaagaagcat gtttttgcta atgctaataa aagaactgct ttcttcgttt tggtcaaatt
    27661 tttacaatta aacggctatc gtttttctgt aacggtagaa gaagcagtaa aaatgtgtgt
    27721 aaccatcgca gtagaagctt taactgatga aaaaatgaca agctactcca aatgggtttc
    27781 tgaacattct gttagagaaa aggtcaaaaa gtaacctagt atgctggatt tgaatgagca
    27841 caagaaaata aatgaacaga caatattaga attctgtaat gcagaaactg atattgtctc
    27901 tttttattga tgaataagaa agtgagaaat tatggaatca aaagttacaa ttatcatgca
    27961 agaaatgtta cctcttttaa ataatgaaca attactagcg ttgagagaga gtttagaaca
    28021 tcatctagta gacggaaaaa agcagcagaa gtattcgaat aataacctgt tgcaactatt
    28081 tattaccgcc aagcaggtag agggctgtag ctcaaaaaca attcgttatt accagaggac
    28141 gattgaaaac ttgtttaatg ctattaaaga gtctgtgaca caactcacaa cagatgattt
    28201 aaggagttat ttagcaaatt accagtctga aaaggattgt agtaaggcaa atttagacaa
    28261 tattaggcgt atattgtctt ctttttttgc ttggcttgag caagaggaat atatcattaa
    28321 aaatcccatt cgacggataa agaaaattaa gactgagcaa aatgtgaagg aaacttatac
    28381 tgatgaacat ttggaaatta tgcgtgataa ctgtgaaaat ttgagagatt tggcaataat
    28441 agacctacta gcatcgacag gtatgcgtgt aggggagctt gtacagttga atcgttcaga
    28501 tattgatttt gaaaacagag agtgtgttgt ctttggtaaa ggaaagaagg agagaccagt
    28561 atattttgat gctcggacga aaattcattt aagaaattat cttaacgaca gaaaagatag
    28621 tcaccctgct ctttttgtaa cgctagttgg aaaagcccag agacttggaa ttgctggtgt
    28681 agagattcgc ttaagaaagt taggagacaa actcggcata caaaaggttc acccacataa
    28741 gttcagaaga actttagcga ctaaggcaat tgataaaggt atgcctatcg aacaagtcca
    28801 aaaactgcta ggtcatagca agattgacac aaccctggcc tatgccatgg tcaatcaaaa
    28861 taatgtcaag cattcacacc aaaaattcat ctcttaaaag caaatcccga tattccgagg
    28921 aggtggttgc atgaagaaag tgaaattagg gcaagtggct acttttatca atggctatgc
    28981 ttttaaacct caagattggt catctgaagg gaaagagatt atcagaatac agaatctgac
    29041 taaaacttca aaagggataa attattattc gggtacgatt gataaaaaat acattgttga
    29101 agctggtgat attcttattt cgtggtcggg tacattaggg gtttttcagt ggtgtggaag
    29161 atccgcagtg ttaaatcagc acatttttaa agtggttttt gataagatag atatagataa
    29221 atcgtatttt aaatatgttg ttgaaaaagg tttacaagat gctgtaaaac atactcatgg
    29281 ttccacaatg aaacatttaa ctaaaaaata ttttgataat attatggttt catatacaaa
    29341 tttgggagag caacaaagaa ttgcaagtga gctggatttg ttaagcaagc tgattttaag
    29401 gagacaagaa caacttgaag agcttaatct acttgtaaaa tcacaatttg cttgtgagat
    29461 agctataaaa gtgtggagaa atagcttgaa atttagtata atatagctaa actatttgtt
    29521 taaagtgaga aaaaaatggg aaattttagc tttcttttaa aaaatgacga atatgaatct
    29581 ttttcaaaac cttgcattga agctgaaaat atgattgcta catcaactgt ggctactgcc
    29641 tttatggcgc gtcgtgcttt ggagcaggct gtccattgga tatatagtca cgattcatat
    29701 ttagaagctc cctattgtgc tactctatct tctttagtat gggatgatga ttttagggat
    29761 atcgtagatt ctgaactcca caagcagata gttctgttga ttcggtgggg aaaccatgct
    29821 gctcatggtg gtgaaattaa ggaacgagaa gcgattttag ctttacatca tttgtatcag
    29881 tttgttaatt ttatcgatta ttgttacagc aatgaatttg tggagcgtta ttttgatgag
    29941 aagtgtttac cactttcagc aaacatcaaa taccgagaaa ctccacaatc tatgataaag
    30001 ttacaagaca gtttaccaga actgcctgat tttcatgaac agatggctgc tcagtccgta
    30061 gaagttcaag agacttatac tgaaaaacgt gagactgcag cgcaacggca agatgtgcct
    30121 ttccatattg aacaattatc tgaggcagag acaagaaagc tctttattga tatcgatctc
    30181 cgtttagcag gatggatatt tgaagaaaac tgtcgtgttg agatagccgt tgatggtctc
    30241 aagcacggtt caggaattgg ttactgtgac tatgtacttt atggtaaaaa tgggaaaatt
    30301 ttagcgattg tggaggctaa aaaagcctct gtcaatccag aagtagggga agtacaggtc
    30361 aaagaatatg ctgaagcttt ggagaaacat atcggctatc agccaatttg ctttattaca
    30421 aatgggttga agcactatat acttgatggt ccgaaccgcc gccagattgc aggcttttac
    30481 tctcaagaag aattgcaatt agtgatggat agacgtcatc ttcaaaaacc gcttgaggat
    30541 atttctagta aaattaggga cgatatttcc gggcgtcact accaaaaaca tgccattgca
    30601 agcgtttgtg aagctttctc tgatcatcgt agacaggcac ttttggttat ggcaactggg
    30661 gctgggaaaa ctcgtacagc agtttctcta gttgatatct tatcacgtca taactgggta
    30721 aaaaacgttc tcttcttagc cgatagaact tccttggtta agcaagcata tgattcgttt
    30781 agaaaattac tcccagatct ttccgtttgt aacttcttag aagataaaga aggagctcaa
    30841 tcaagtcgca tggtcttttc aacttatccg accatgattg gagcgattag tggtcaagaa
    30901 gaagtaaatc aacgcccttt cactgttggg cattttgacc ttatcataat tgacgaatct
    30961 caccgttcta tttatcagaa atacaagtcc atttttgatt attttgatgc aagaattgta
    31021 ggcttaacag ctactccgcg tcaagattta gataaaaaca cctatggatt ctttaatttg
    31081 gagaatgggg ttccaacata tgcatatgat ttggaagagg ctgttaaaga cggatattta
    31141 gtagcctatc attctatcga aaccaaactg aaactaccta cggatggtct acattatgat
    31201 gatttgtccg aagaagaaaa ggaacatttt gatagcaaat ttgaagacga tagctgtgaa
    31261 aaagatattg atgggagtgt atttaattcc tttgttttca ataaaagtac agtagaaatt
    31321 gttttaaatg aactcatgac aagaggaatt cagacagcct cgggtgatga aattggtaaa
    31381 actattattt ttgctaaaaa tcatgatcat gcggaatata tcagaggtat ttttaacaac
    31441 cgctatcctg aaaaagggag cgactatgct caggtgattg attatagtat taagcattat
    31501 cagaccttga ttgatgattt taaaattaag gagaagtatc ctcaaattgc gatttctgtc
    31561 gatatgttag atacaggtat tgatgtacca gaggttgtta atttagtctt cttcaagaaa
    31621 gtacgctcta aaactaagtt ttggcagatg attggtcgag gaacccgtct atgtaaagat
    31681 ttatttggac ctgagcagga taaggaaaac ttcttggtat ttgattatgg ggacaatttt
    31741 gattattttc gtgcagatcc aagagatgga gagggtcgtc acattgtttc gttgactcag
    31801 cgtttattta atatcaaagt ggacttgatt cgagaacttc agggactcca ataccaagaa
    31861 gaacagtttg cgagagcata ccgtcagcag cttgtctcgg aacttcaagg tcgtatagag
    31921 agcttaaatg agttggactt cagggttcgt atggttttag atacagttta tagctatagg
    31981 aaattggaaa gttggcagaa tctaactgct gttacaagtg aaaccattca aaaaaatctc
    32041 tctccgcttt tatttgatga agataaagaa gatgagatgg cgaggagatt tgatttgtgg
    32101 ttgcttcata ttcagttggg gcaactgaca gctaaatctt ccactgttca tatttcccaa
    32161 gtgatgaaga cggctagagc tctttctgct attggcaata tcccgcaggt ttttgagcag
    32221 gctgaaatta tcaggaaagt acaggagcct gaattttgga aagaagttaa cttgtctgat
    32281 ttggaaaaaa ttcgtcttgc tattcgagat ttattacagt ttttggataa aacagaccgt
    32341 aaaccctact atgttaactt tgaagatcgt atactctcca ctgttcacga gaccacagca
    32401 tttttgcagg tcaacgatct tcggtcttac aatgaaaaag ttgagcatta tttgaaaact
    32461 catctggatg aggagtccat ttctaagcta taccataata aaaagttgac atctgatgat
    32521 atgcttgcac ttgaaaaatt gctttgggaa aaattaggta gtaaagcaga ctaccaaagt
    32581 cattatgaaa ataaggcaat tccgagattg gttcgtgaga ttattggctt agatagagag
    32641 tctgccaatc gtattttttc taaatttttg tcggatgaga atcttaatgc caggcagatt
    32701 tcatttgtaa aattgattgt agactacatt gtagaaaatg gttttttaga gacgaaagtg
    32761 ttaacgcaag agccgtttaa atcttatggt tctgttcaac tactcttcca acaccaacta
    32821 ccagtacttc gtaatattgt tcaaatcatt gaacttatca ataatcgagc tggagaagcg
    32881 gcttaaattc taaagtgatt gccatgctga gactcattta aaattaaaaa gagtagaaat
    32941 ttatgctata tatgagaagt tttattagga agaatgtcat cgttttccta gaatacagta
    33001 tcagttgtta agtggctgat aaatttcaaa gtagatactt gtaccacgat gtttgttgat
    33061 agagttatta acaaaagagc tactttgatt ttaaagaaat agaaaacaaa aagccgagca
    33121 agaattcaat tgcaggagaa aatgaaataa tactcaatga aaatcaaaga gcaaactagg
    33181 aaactagctg caggctgctc aaaacactgt tttgaggttg tagataagac tgacgaagtc
    33241 agctcaaaac atggttttga ggttgtagat gaaactgacg aagtcagtaa ccatacctac
    33301 ggcaaggcga cgttgacgcg gattgaagag attttcgaag agtataaatc ttcctaggat
    33361 aaagcaaaac gcatagtatc aagggttttc aacacttgat actatgcgtt ttctgatgtt
    33421 aaagactttc taccagtttt ttttaagcat aattgttagt tgtagtcatt tattattctt
    33481 caaagaaaaa tggtggggcg aattttttca gttcttcaaa gcacttttga gcagtatctg
    33541 catcttcaca gatgataaga cagacatcat taccacaaag ggtagcgata gcgtcaggga
    33601 agctcaaagt atcaatgata gaaccaaagg attgagccag tccaggaagg gtttttagta
    33661 ggacttggtg ttgaactggg cgcatccaga caagggcgtc ttccatgtag agttcgagac
    33721 gtttttccca ttttgagatg gaaccattgt taagaacata ataagcgcta tcttcttcgc
    33781 ggacttttga taggttcata tttttgatgt cgcgtgagag ggttgcctgg gttacttgaa
    33841 tgtcgttctt agcaagaagg gcttgcaact cagcctgtgt atgaatcttg ttttttgtga
    33901 taagagcgcg tataagttgg tggcggtgtt ctgatttatt cataataatg taactccttt
    33961 tagcaaggta aggtaagcat ggactgagcg aggtcgacag tcaagtggta gtctgtattg
    34021 tcacggatgg tgatttcaaa gtcagtagta tagaggacta aacggagagt gtctccttct
    34081 tttagcttgt aaatagttgg ctgcagttca aattgaacgt ccatccattc atctgcagta
    34141 atatcctcta ctaacagtaa atcatttcta ttttgtaaat taaggtaacc ttttgtcacg
    34201 actcgttgtg cctctggtct aaatggcaat tcacagagat tttccaacat gtgatagcga
    34261 ccgttgtcaa tggttctagc acttaaaata gctggataag gttgtaggta tttcttttgc
    34321 ccaaattcta gcagttgggc agataagagc cccttgtttg tactggattt gatacgaaga
    34381 ttgagctgag cgcgaccgtt taggtggaga tctttagtca caggaaggtt aatagtaatc
    34441 tgattggctt tcccttgata gagctctgta ttgaaggttt ggtatgtctt accatagcgc
    34501 tcaaaatcct tatctgggta ctggttttga atagcttgct cttcttgacc aagtgagaag
    34561 gtttcacagt tttcttgccc accgaagtta tcaagtgata accaagtctg tggagctgta
    34621 ttgtcctgcc agataacagt aggaagttga aagtctgttt cctgtcctag taatttcttg
    34681 gttaataagg catttatgga ctcacggaag tcaattgatt gccaattgtt catgtaaaca
    34741 tgggcaccat tatggaaaaa gagatgcttg tgtatatgag taggaagagc atggaacatc
    34801 tggtaaacat gaagtggttt gacattccaa tcctgagaac catgagtaaa gacaacctct
    34861 gcctttactt tatgggcatt gagcagataa ttgcggtcat gccaaaactg attgtagtcc
    34921 ccagtttttc ggtctagctg agctttcact ttttctaagt cagcttggtg agcttcattg
    34981 ccacggatat agtcgccagc taagagatta cgagaatagg ttaactcagc aagggagtca
    35041 aagtcctcac ctggataacc acctgggcta gtcaccagac cgttttcacg gtagtagttg
    35101 taccatgatg aaattcctgc ctcggcaatg ataacttcta aaccatcgac tcctgtagtc
    35161 gcaagaccat tggacatggt acctagatag gaaagtcctg ttgtagcaac ttttccgttt
    35221 gaccaatcag ccttgacttg acgctggcgc gtgtgatcag taaaggcacg gcaacgaccg
    35281 ttaagccaat cgatgacatt tttataagcc tcgatttgct ggtagtctcc attagtcatg
    35341 aaacctgtcg agtctttggt accaacacct gagacataga gattggcaaa gcctctcgga
    35401 aggaagtagt cgtttagtgt atagctagag ttgatgtgag ttagcttttc ctcagcctct
    35461 gctataagct cagctttacc ttggggttgg acgagattta gttgaggttt ctctagctca
    35521 atcttgtgag gaagcttaac ctcaagctcg ccctccatct tgtagagagc cttgtcacta
    35581 gccttgtcat tggttccctg atgataaggg ctggctgtca tgatggcagg gatttttcca
    35641 tcaaaacgag ggcgaataat gctaaccttt actaggtctg atagcccttt ttggtcagta
    35701 tcgacacgag actcaacgta aacgacttca cgaatgacat cctggttaga aaaagtagcc
    35761 aaactcttgc cgttaaagta gtggtagtca ttatcctccg gaataagacc atcactaaca
    35821 agttggtcga taagagtatt tccttttttg gtgcgagtat tgagtaactg atagagattt
    35881 tcaatcaagt caccatatat aatgggaaat ccagtttctt tacgaaaaac gtcactatct
    35941 tcgaagtcaa ccaaataaga aaagcctaaa agttgaaaag caacagtata aaaaatatct
    36001 gctgtcagtt catcttctga ttgaaaaaat gtcagcaggt ctgttttttt atcagctgct
    36061 aggatagaaa gtgggtagtt ggtgtcttga taagtgaaaa agaaacgacg taaaaaggtt
    36121 tcaagtgagt ctttgtgatt ggctgtattt tgtaaatcaa agccacattt ttttagttca
    36181 gataagacat tttcttttgg aaaattgata taactatatt gattaaaacg catagaacct
    36241 ccatatagaa tgacagttaa ggttattata tcaaaaaaaa agcagaaagg gaattgttaa
    36301 cttcaaaagg aaataatcca ataaaaatga ataaagtact aaattcaata tagagaacag
    36361 agtaacaata agaataaaat agatagggta taaaagttct aggagattta tatt
//
LOCUS       DBERMM010000019        33390 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.019, whole genome shotgun sequence.
ACCESSION   DBERMM010000019 DBERMM010000000
VERSION     DBERMM010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 33390)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33390)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33390
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.019"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(381..1361)
                     /locus_tag="ACL8AS_001158"
     CDS             complement(381..1361)
                     /locus_tag="ACL8AS_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetylxylan esterase"
                     /protein_id="HGS1229026.1"
                     /translation="MKNPALLEEIKTYRGRDEVPEDFDAFWDGEVKNVSTLPSYHLEE
                     RDFHISQVKCYELTFEGSKEGKVYARIVLPKSEEKVPLIFHFHGYMGRGWDWADMLVF
                     TVAGYGVVSMDVRGQSGYSQDGLRSPLGNTVKGHIIRGAVEGRDHLFYKDVYLDIYQL
                     VEIVASLSQVDEKRLSSYGASQGGALALVAAALNPRIQKTVAIYPFLSDFRRVIEIGN
                     TSEAYDELFRYFKFHDPFHETEEEIMATLAYIDVKNLAHRIQGEVKMITGLDDDVCYP
                     ITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYNWLCGSEIPFKYLK"
     gene            complement(1677..3692)
                     /gene="recG"
                     /locus_tag="ACL8AS_001159"
     CDS             complement(1677..3692)
                     /gene="recG"
                     /locus_tag="ACL8AS_001159"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HGS1229027.1"
                     /translation="MNLHQPLHVLPGVGPKSAEKYAKLGIENLQDLLLYFPFRYEDFK
                     TKQVLELEDGEKAVLSGQVVTPASVQYYGFKRNRLRFSLKQGEVVFAVNFFNQPYLAD
                     KIELGATLAVFGKWDRAKASLTGMKVLAQVEDDLQPVYRLAQGISQASLVKVIKTAFD
                     QGLDLLIEENLPQSLLDKYKLMSRCQAVRAMHFPKDLAEYKQALRRIKFEELFYFQMQ
                     LQTLKSENRVQGSGLVLNWSQEKVTAVKVSLPFALTQAQEKSLQEILTDMKSDHHMNR
                     LLQGDVGSGKTVVAGLAMFAAVTAGYQAALMVPTEILAEQHFESLQNLFPNLKLALLT
                     GSLKAAEKREVLETIAKGEADLIIGTHALIQDGVEYARLGLIIIDEQHRFGVGQRRIL
                     REKGDNPDVLMMTATPIPRTLAITAFGDMDVSIIDQMPAGRKPIVTRWIKHEQLPQVL
                     TWLEGEIQKGSQAYVISPLIEESEALDLKNAIALSEELTTHFAGKAEVALLHGRMKSD
                     EKDQIMQDFKERKTDILVSTTVIEVGVNVPNATVMIIMDADRFGLSQLHQLRGRVGRG
                     DKQSYAVLVANPKTDSGKDRMRIMTETTNGFVLAEEDLKMRGSGEIFGTRQSGLPEFQ
                     VADIIEDFPILEEARKVASYISSIEAWQEDPEWRMIALHLEKKEHLD"
     gene            complement(3711..4814)
                     /gene="alr"
                     /locus_tag="ACL8AS_001160"
     CDS             complement(3711..4814)
                     /gene="alr"
                     /locus_tag="ACL8AS_001160"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000648075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008784 - alanine racemase activity
                     [Evidence IEA];
                     GO_process: GO:0006522 - alanine metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HGS1229028.1"
                     /translation="MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAY
                     GHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFT
                     LTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVE
                     GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVR
                     MGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIA
                     TVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKPYPLGTKVTLIGSNG
                     DKEITATQVATYRVTINYEVVCLLSDRIPREYY"
     gene            complement(4804..5166)
                     /gene="acpS"
                     /locus_tag="ACL8AS_001161"
     CDS             complement(4804..5166)
                     /gene="acpS"
                     /locus_tag="ACL8AS_001161"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA];
                     GO_process: GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HGS1229029.1"
                     /translation="MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGR
                     RQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSIS
                     HTDQFVTASVILEENHES"
     gene            complement(5211..6242)
                     /locus_tag="ACL8AS_001162"
     CDS             complement(5211..6242)
                     /locus_tag="ACL8AS_001162"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HGS1229030.1"
                     /translation="MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGED
                     DRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLV
                     HQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGAR
                     SVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPL
                     AHVILRGAVNEYGNYMPNYYYENLLQAIERYETMGLENPFILIDTNHDNSGKQYMEQI
                     RIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEVFGCSITDPCLGWENTEALV
                     EEIYVTLTK"
     gene            complement(6244..7275)
                     /locus_tag="ACL8AS_001163"
     CDS             complement(6244..7275)
                     /locus_tag="ACL8AS_001163"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000232189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HGS1229031.1"
                     /translation="MVFTAKSSKINIEEVRALSKLEGQALERKSQRDQELEAIIRGED
                     QRILLVIGPCSSDNEEAVLEYAKRLAVLQEEVADRIFMVMRVYTAKPRTNGDGYKGLI
                     HQPNATEAPSLINGIKAVRHLHYRVITETGMTTADEMLYPENLPLVDDLISYMAVGAR
                     SVEDQQHRFVASGAGFSTGFKNPTSGNLNVMFNGIYAAQNKQSFLFLGKEVETTGNPL
                     SHAILRGALNEYGKNIPNYYYDNLIDTIAQYEKMGLENPFIIIDTNHDNSGKQYIEQI
                     RIVRQTLINRAWNEKIKQFVRGFMIESYLEDGRQNEPEVFGKSITDPCLGWDNTEALV
                     REIYKTLGE"
     gene            complement(7356..9869)
                     /gene="secA"
                     /locus_tag="ACL8AS_001164"
     CDS             complement(7356..9869)
                     /gene="secA"
                     /locus_tag="ACL8AS_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HGS1229032.1"
                     /translation="MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAK
                     TVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRT
                     GEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKS
                     PMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEAR
                     TPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLE
                     NLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGL
                     HQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIP
                     IPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKL
                     VAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCV
                     IGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSE
                     EAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYTQRYDVITADRDL
                     APEIQAMIKRTIGRVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAI
                     KEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLR
                     GYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRN
                     IAAHQASMPEDLDLSQIGRNELCPCGSGKKFKNCHGKRQ"
     gene            complement(10015..10302)
                     /locus_tag="ACL8AS_001165"
     CDS             complement(10015..10302)
                     /locus_tag="ACL8AS_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000940707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229033.1"
                     /translation="MAHLKSFITRYSKVYIGLVLLIWLSFFFIPWDRAILGVRIDIFI
                     IQKVLLVFGILSILMALLSKKVSLFVFGLICWLSLWINLFITFAILPIFGN"
     gene            complement(10313..10963)
                     /locus_tag="ACL8AS_001166"
     CDS             complement(10313..10963)
                     /locus_tag="ACL8AS_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1229034.1"
                     /translation="MRLEIINGQKIYGKRPILNQLNLVFQSGKIYGLKGDNGSGKTVL
                     LKILAGYIKLDKGKVLQDGKVYGVKNHYIQDAGILIEKVEFLSHLSLRENLELLRYFS
                     SKVTEKRIAYWIQYYDLQEFEDVEYRHLSLGTKQKMALIQAFISSPSILFLDEPMNAL
                     DEKSVRLTKQVILSYLKKENGLVILTSHISEDISDLCTDVLVVENGHIQYVKDIQS"
     gene            complement(10967..11608)
                     /locus_tag="ACL8AS_001167"
     CDS             complement(10967..11608)
                     /locus_tag="ACL8AS_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229035.1"
                     /translation="MFKNFNNIWLKRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFF
                     KRELISIFSYNDYSEANLEIPKLLLNLSLFMVGWLSVILLESDLADHYHHLIRYQSSS
                     FFDYTRKRLVVISKFFTQDLFVWFLGLLPLGIHFKTVALFFLLAQLMMLYLLLSYLIA
                     LISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLVLLSLLVMLILSRLEEKFKKG"
     gene            complement(11601..12392)
                     /locus_tag="ACL8AS_001168"
     CDS             complement(11601..12392)
                     /locus_tag="ACL8AS_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229036.1"
                     /translation="MKIPLLTLARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDL
                     AKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIG
                     REVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIVTYFFGTFSPLGWNSLFSDGSGLQR
                     LLDGEIKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAITYLMFLWLGSMLLYSA
                     LPYYMVPMTSLMQASYGDVSLMKLFTPYILYIVPYMVLEKYEDNV"
     gene            complement(12577..12912)
                     /locus_tag="ACL8AS_001169"
     CDS             complement(12577..12912)
                     /locus_tag="ACL8AS_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229037.1"
                     /translation="MEYLFKMIILLPCFYFFSWIEKANRDSKIFPIFYYFYWIYITLY
                     ALFSLAWTVFSVLFFNIVLRNLTDIKLWGIWLLLLLIAFASGWLDYICFKKMLDLRRE
                     LGKSKGGRH"
     gene            complement(13052..13387)
                     /locus_tag="ACL8AS_001170"
     CDS             complement(13052..13387)
                     /locus_tag="ACL8AS_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229038.1"
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWFYIPFY
                     SLFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQE
                     LGKSKGGRH"
     gene            complement(13475..14785)
                     /gene="der"
                     /locus_tag="ACL8AS_001171"
     CDS             complement(13475..14785)
                     /gene="der"
                     /locus_tag="ACL8AS_001171"
                     /EC_number="3.6.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HGS1229039.1"
                     /translation="MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYA
                     TGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEY
                     VARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIV
                     ENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFT
                     DTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDK
                     RIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQ
                     RLHKLPEMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKP
                     PTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     gene            complement(14799..15512)
                     /locus_tag="ACL8AS_001172"
                     /pseudo
     CDS             complement(14799..15512)
                     /locus_tag="ACL8AS_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent oxidoreductase"
     gene            complement(15509..16405)
                     /gene="dnaI"
                     /locus_tag="ACL8AS_001173"
     CDS             complement(15509..16405)
                     /gene="dnaI"
                     /locus_tag="ACL8AS_001173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HGS1229040.1"
                     /translation="MESVGDVLKRQPSRFYYQDLVQKIMKDPDVAAFIQQESLTPEEL
                     NRSISKFNQYITERDKFLRGDTDYIAKGYKPILVKNHGYADVSYEETPELIAAEKEAA
                     IKNRLKLINLPASLKKASLAQVDLDDLGRLPVFEKLLAFVEQYPAIRKGLYLYGDFGV
                     GKSFMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAISDGNVKTLVDEIKLSEVLILD
                     DIGAEQSTVWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKVKHGNDETWEA
                     RRVMERIRYLAEETRLEGVNRR"
     gene            complement(16406..17575)
                     /locus_tag="ACL8AS_001174"
     CDS             complement(16406..17575)
                     /locus_tag="ACL8AS_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HGS1229041.1"
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISF
                     WDNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLALHAPLSSQD
                     FLEHPVYRRLLEKKIGDSAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKK
                     VANDFDLEHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVI
                     STKRMREKIAQKPVSSDFSLKETTIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQ
                     QMAGLGLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEKAVLRIRER
                     GQKAKTQKQNQTAPVKTNVPKWSNPEYKNETSEETRLELERKKQELLARLEKGGD"
     gene            complement(17576..18049)
                     /gene="nrdR"
                     /locus_tag="ACL8AS_001175"
     CDS             complement(17576..18049)
                     /gene="nrdR"
                     /locus_tag="ACL8AS_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0140110 - transcription regulator activity
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator NrdR"
                     /protein_id="HGS1229042.1"
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERV
                     EERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENE
                     IQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            18189..18554
                     /locus_tag="ACL8AS_001176"
     CDS             18189..18554
                     /locus_tag="ACL8AS_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HGS1229043.1"
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEA
                     GVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTH
                     FGYEKEELPGVVSDYIKGV"
     gene            18559..19254
                     /locus_tag="ACL8AS_001177"
     CDS             18559..19254
                     /locus_tag="ACL8AS_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229044.1"
                     /translation="MSLLVFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTT
                     LIKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYK
                     DFNLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPA
                     ARAYILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESG
                     ESIDQLFRQEFKA"
     gene            19271..20038
                     /locus_tag="ACL8AS_001178"
     CDS             19271..20038
                     /locus_tag="ACL8AS_001178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229045.1"
                     /translation="MFWNLVRYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYQ
                     ESQATMLLFLATVFGGLMLTLGISTIFLIIKRFKGSVYDRQGYLTLTLPVSEHHIITA
                     KLIGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLN
                     TISGILCIYLAISIGQLFNEYRTALAVAVYIGIQIVIGFIELFFNLSSNFYVNSLVGL
                     NDHFYMGAGIAIVEELIFIAIFYLGTYYILRNKVNLL"
     gene            complement(20391..21590)
                     /locus_tag="ACL8AS_001179"
     CDS             complement(20391..21590)
                     /locus_tag="ACL8AS_001179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229046.1"
                     /translation="MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGS
                     SMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSV
                     LKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEA
                     KENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYA
                     RMMALFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISL
                     FMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAAGDNLLLKIGSYIPF
                     ISTFFMPFRTINGYAGGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTF
                     KRALSYK"
     gene            complement(21587..22480)
                     /locus_tag="ACL8AS_001180"
     CDS             complement(21587..22480)
                     /locus_tag="ACL8AS_001180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229047.1"
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIF
                     HSILKFLEYQGEIGLDGQDIRQETYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDA
                     KEVKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLD
                     PVNTELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQ
                     YGKTRLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIA
                     TFDQQAPTIDEIFKLESGVEV"
     gene            22603..22794
                     /locus_tag="ACL8AS_001181"
     CDS             22603..22794
                     /locus_tag="ACL8AS_001181"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229048.1"
                     /translation="MKSKEQTRKLVVGCSKYSFEVADKTDEVSSKHCFEVVDRTDEVS
                     NYIYSKAKLTWFEEIFEEY"
     gene            23162..23381
                     /locus_tag="ACL8AS_001182"
                     /pseudo
     CDS             23162..23381
                     /locus_tag="ACL8AS_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            23796..24413
                     /locus_tag="ACL8AS_001183"
     CDS             23796..24413
                     /locus_tag="ACL8AS_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HGS1229049.1"
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQS
                     KETLSAFIQQVGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGI
                     VIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADF
                     LCMLAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(24733..25620)
                     /gene="scrK"
                     /locus_tag="ACL8AS_001184"
     CDS             complement(24733..25620)
                     /gene="scrK"
                     /locus_tag="ACL8AS_001184"
                     /EC_number="2.7.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008865 - fructokinase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="fructokinase ScrK"
                     /protein_id="HGS1229050.1"
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKT
                     IEFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPM
                     YFTTDVNSSAYGEVVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHY
                     YVARHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGETIELNNPVWDVQAYYI
                     AQAAVNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAV
                     AGNGSATLGNFVLAKEVSK"
     gene            complement(25769..27652)
                     /locus_tag="ACL8AS_001185"
     CDS             complement(25769..27652)
                     /locus_tag="ACL8AS_001185"
                     /EC_number="2.7.1.211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-specific PTS transporter subunit IIBC"
                     /protein_id="HGS1229051.1"
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEV
                     IENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQ
                     RAIRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPG
                     LVVWSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGS
                     VLPAFIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYI
                     LIATKAILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAA
                     MTAQGAATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAG
                     AIGGGLASILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYE
                     DEVDATAAAKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQG
                     IAVKPSQGVVYAPADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKV
                     AQGNKVKAGDVLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVAKGDAVIE
                     VKI"
     gene            28029..29483
                     /locus_tag="ACL8AS_001186"
     CDS             28029..29483
                     /locus_tag="ACL8AS_001186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HGS1229052.1"
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGL
                     LNDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLVHFRETGVKVLPDTPLDS
                     HGAYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPAD
                     STDHFRDPQIFNFKGQYYAVVGGQDLEKKGFVRLYKAVNNDYTNWQAVGDLDFANDRT
                     AYMMECPNLVFVEEQPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQ
                     LQNMDYGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDRFDHQGTFSLVKELTIKDD
                     KLYQYPVAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSIN
                     FDLVNGQVTVDRSQAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVF
                     SGRVFPHADQNGILIKSGNPTGIYYELDYGRKTN"
     gene            29464..30429
                     /locus_tag="ACL8AS_001187"
     CDS             29464..30429
                     /locus_tag="ACL8AS_001187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HGS1229053.1"
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMREL
                     GYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDS
                     EKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAG
                     GVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKE
                     MEIKNILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQ
                     LATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(30464..31738)
                     /locus_tag="ACL8AS_001188"
     CDS             complement(30464..31738)
                     /locus_tag="ACL8AS_001188"
                     /EC_number="1.1.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004420 - hydroxymethylglutaryl-CoA
                     reductase (NADPH) activity [Evidence IEA];
                     GO_function: GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_process: GO:0015936 - coenzyme A metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA reductase,
                     degradative"
                     /protein_id="HGS1229054.1"
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTV
                     ADQLSENVVGTFSLPYSLVPEVLVNDQEYTVPYVTEEPSVVAAASYASKIIKRTGGFT
                     AQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
                     QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSL
                     VTASCRMAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIAT
                     GNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPR
                     VALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGA
                     SESEVAPLVERLISDKTFNLETAQRYLENLRS"
     gene            complement(31738..32910)
                     /locus_tag="ACL8AS_001189"
     CDS             complement(31738..32910)
                     /locus_tag="ACL8AS_001189"
                     /EC_number="2.3.3.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004421 - hydroxymethylglutaryl-CoA
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="HGS1229055.1"
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSI
                     APLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFA
                     RSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
                     LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQK
                     RYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGN
                     IYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLN
                     KLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            complement(33041..33238)
                     /locus_tag="ACL8AS_001190"
     CDS             complement(33041..33238)
                     /locus_tag="ACL8AS_001190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229056.1"
                     /translation="MIAEKVSKTLDKTFDKDVREIPTSQFYQKFVDEMGRTYSGNLIL
                     QELITVNGAYKATYIGELSSN"
BASE COUNT         9789 a         7476 c         6326 g         9799 t
ORIGIN      
        1 aacatatata cggcaaggcg aagctgacgt ggtttgaaga gatttttgaa aagtattaac
       61 acctacagac aagcctaacg atagcaagaa ctaccctact cgataggtat cggcttttgc
      121 tttctgaaaa aaattatttt aagcaatttg acaaatctag caacaaaaaa ttctataaat
      181 ataatagatt gaaactagaa tagtacacat ctacttctaa aacattgtta gaaatcgatt
      241 tgactctcct gatcgatttg tcctgttctt gtttcatttt actatatttc catgataaaa
      301 cgcatagtat caagttttct taatcccctg atactatgcg tgtttgtaat ttttaagatt
      361 ttgtgcttag agtcgactcc ttattttaga tatttaaaag gaatctcact tccacagagc
      421 cagttgtaga cttggtcatt gacaaataca ttcatggctt cgtgagcata ctcaggcatg
      481 atgcgatagg ttttatcgca ggtcagacga ttataaatcg caaactgggt aatgggatag
      541 caaacatcgt cgtccaagcc cgtaatcatc ttaacctcac cttggatacg atgggcaaga
      601 tttttgacat cgatataggc aagggtcgcc atgatttcct cctctgtttc atggaagggg
      661 tcgtgaaact tgaaataacg gaaaagttcg tcgtaagcct cgctagtatt accaatctca
      721 atcacccgtc tgaagtctga caagaaggga taaatggcaa ctgttttctg aattcgagga
      781 ttgagcgctg ctgcaactag agctagagcc cctccttgtg aggcaccata gctagaaaga
      841 cgcttctcat caacctgaga cagactagca acaatttcga ccaactggta aatatccaga
      901 taaacatcct tataaaagag gtggtcccga ccttccacag caccacggat aatatgcccc
      961 ttcacggtat ttcctaaagg agaacgcaag ccgtcttgtg agtaacctga ctggccccgc
     1021 acatccatgg aaacaacacc gtaaccagct acggtgaaga ccagcatgtc ggcccagtcc
     1081 cagccacgtc ccatataacc atgaaaatgg aagattagtg gaaccttctc ctcactcttt
     1141 ggaagaacaa tgcgtgcata gacctttcct tccttgcttc cttcaaatgt taactcatag
     1201 cacttgactt gagaaatgtg gaaatctctt tcctccaagt ggtaggatgg aagtgtggaa
     1261 acatttttca cttccccatc ccagaaagca tcaaagtctt ccggaacctc atcccttcct
     1321 ctataggtct taatttcttc tagcaaagct ggatttttca tagcatgctc cttttatttt
     1381 gtaatcgtta ccacaactgt agcatatcta tgtaatcaat gcaagaaaga aggataaata
     1441 gaaagtgaat ttagattctt tacttttagg atgatgggct gaaagtagtt ttagaaacga
     1501 aaaagagcat ttcgctctct cttctgttta tactagtttt ttgcttcctt cttttggaaa
     1561 gtggtttggt aatttacttt aatcgttact gtcatatgag agtcctcgtt tctttttgat
     1621 gactttagta taagagccaa acctaaaaac tagcttaagt tttccttaga gaaagcttaa
     1681 tccagatgtt ctttcttttc cagatgaagg gcaatcatgc gccactctgg atcttcttgc
     1741 caagcttcta tagaactaat gtagctagca acctttcttg cttcttctaa aatcggaaaa
     1801 tcttcgataa tatcagccac ttggaactct ggaagtcctg actgtctggt tccaaaaatc
     1861 tcaccagaac cacgcatttt caaatcttcc tccgcaagga caaatccatt ggtcgtttct
     1921 gtcatgatgc gcatgcggtc tttcccagaa tccgtcttgg gattggcaac gagaacagcg
     1981 taggactgct tgtccccccg accgacacga cctctaagct ggtgaagttg actgagaccg
     2041 aagcgatcgg catccatgat aatcatgaca gtcgcattgg gaacgttgac cccaacctca
     2101 ataaccgtcg tcgaaaccag aatatccgtc tttctctcct tgaaatcctg catgatctgg
     2161 tctttttcgt cactcttcat cctaccatgt agaagagcca cctctgcctt gcctgcaaaa
     2221 tgagtcgtca actcctctga taaggcaatg gcatttttca aatctagagc ttctgattct
     2281 tcaatcaaag gagagatgac ataggcttgg gaaccttttt gaatttcccc ctctaaccaa
     2341 gtcaagacct gaggtagttg ctcatgtttg atccagcgcg tcacaatagg cttccgacct
     2401 gctggcatct ggtcgataat ggaaacatcc atatctccaa aggctgtgat ggcaagcgtc
     2461 cgtggaatgg gagtcgccgt catcatgagg acatctggat tgtcaccttt ttcccgtaaa
     2521 atacgccttt gccctacacc aaaacggtgc tgctcatcga taataatcaa accaagacga
     2581 gcatactcca ccccatcttg tatcagagcg tgagttccta taatcaaatc agcctcaccc
     2641 ttggcaatgg tctccaagac ctctctcttt tctgcagctt tcaaggaacc tgtcaagaga
     2701 gccagtttca aattgggaaa aaggttctgt aaactctcaa agtgttgctc tgcgaggatt
     2761 tctgttggta ccattagggc agcctgataa cctgctgtca ctgccgcaaa catggccaag
     2821 ccagcgacta ccgtttttcc actccccaca tccccttgta ggagacgatt catgtggtgg
     2881 tcggacttca tatcagttaa aatttcctgc aaactctttt cctgagcttg ggtcagggca
     2941 aaaggaagac ttactttaac tgctgtcact ttttcctgag accaattcag aaccagacca
     3001 cttccctgaa ctctattttc agacttgagc gtctgcaact gcatttggaa ataaaagagt
     3061 tcctcaaact tgatacggcg aagagcctgc ttgtattctg ccaaatcctt tggaaaatgc
     3121 atagctcgga ctgcctgaca acgggacatg agtttgtatt tgtctagtaa agactggggc
     3181 agattttctt ctatcaagag gtccagtccc tgatcaaaag ccgtcttgat gaccttaacc
     3241 agactggcct gactgattcc ctgagccaga cgatagacag gctggaggtc atcttctacc
     3301 tgagccagaa ccttcatccc agtcagacta gccttagcgc ggtcccattt tccaaagaca
     3361 gcaagggttg ctcccaactc tattttatca gccagatagg gctggttaaa gaaattcacc
     3421 gcaaaaacga cctctccctg cttgagacta aaacgcaggc gattgcgctt gaaaccataa
     3481 tactggacac tagcaggagt cactacctga ccagaaagaa ctgccttctc accgtcttcc
     3541 agctccagca cctgcttggt tttgaagtct tcataacgga aaggaaagta gagcaagaga
     3601 tcttgcaagt tttcaattcc tagtttggcg tatttttctg ctgactttgg tcccacacca
     3661 ggcaagacat gcaagggttg atgtagattc atgctccact cctttctttt ctaataatat
     3721 tctctcggaa tacggtcgct gaggaggcaa accacctcat agttaatggt tacgcggtag
     3781 gtcgctacct gagttgcagt gatttcctta tccccattgg agccaatcaa ggttaccttg
     3841 gttccgagtg ggtaaggctt aggcaatcga atagtgattt ggtccatcga aaccctgccg
     3901 acaattgggc aagcttggcc atctaccaag acagagaaat tttgcatgtc tcttgtccat
     3961 ccatctgcat acccgattgg cacggtcgcg atgacttgct cgctatccgc ttgataagtt
     4021 gctccatagc ccatgcaagc tccagctgga actgtcttga catgaaccag agcagactcc
     4081 aaggtcaagg ccggtatcaa atcataaggc aaatccaaga ccgctccact tggattgagg
     4141 ccatacatgg catctcccat acgaaccgca ttgaaaatag tctctacatg ccaaagagtc
     4201 gttgcagaat tgctagcatg aaccagctct ggaacttcct tcatactagc taaaatagtt
     4261 ttaaaccgtt ctaactgggc attaaaatag tcatctgatt cctcatcagc agtagcaaag
     4321 tgggtaaaga ttccttcaac acaaacaccg tgttgttgga gcaaatcttg agcctgctca
     4381 acctcacttg cctctctaaa accaatccgt cccatccctg aatcaatctt gaggtggact
     4441 gtcaatccag ttaggtccac ttccttatct aagagtgctt gaatccactc cagtccagcc
     4501 actgtcaagg tgaagtcata ttctttagct agagcaacag cttcgatttc agaaactcct
     4561 aaaatgagga ttggcttgct gagtccagct tgtctgagtt caatggcttc atcgatattg
     4621 gaaacgcaaa agccatcaac atcatcttga attgccttgg caacggcaac agctccatga
     4681 ccataagcat tggccttgac cacagccaac ttgagcgttc cttgagggat atgagccccc
     4741 atttgctgaa tattttgtcg aatagctccc agatgaatca gagccttggt tggtctatgt
     4801 ggactagctt tcatgatttt cctccaaaat gacactggct gtcacaaact gatcggtgtg
     4861 gctgatagac agccaaatct ttcctgaaaa tggtgcctga ctaaaataag gcgccccacg
     4921 ttcattgttc aagacttcca aatcctgaaa accgagcttg ctaatgcccg ttcccatagc
     4981 cttggaaaag gcctccttag ccgaccagcg accagctaaa tattctattt gcctgcgtcc
     5041 tttgagactg gtgaagcgct ccatttcctg agcggtcagt acacgcttag caaatccttc
     5101 atgtcgtgta actgcgcttt ctatcgaagc caattcttcg atgtcaattc cgtgtccaac
     5161 tatcattctc atcaaaagga gttgagattc cccaactcca tccttttcac ttattttgtc
     5221 aaggtaacat aaatctcttc taccaaggcc tctgtatttt cccaacctag gcaagggtca
     5281 gtaatagagc aaccaaagac ctctggttgg ttttgacgac catctgctag gtaagattca
     5341 atcataaatc ctcgaaccgt ctttttaatt ttctcattcc aatcacgatt ctgcaaggtc
     5401 tggcgaacaa ttcgaatctg ctccatatat tgcttgcctg agttatcatg gttggtgtca
     5461 atgaggataa aaggattttc aagtcccatg gtttcatagc gttcaatggc ttggagtagg
     5521 ttttcatagt agtaattcgg catataattg ccatactcgt tgactgctcc acggaggata
     5581 acatgggcca aaggattacc tgatgtctca acttcctgcc catgataaag gaaggtttgc
     5641 ttgttttgag cagcatagat ggcgttaaac ataacaccca aatttcctga ggttggattt
     5701 ttcatcccta ctggtgcatc aatcccagaa gccacaaagc ggtgctcttg gtcttccaca
     5761 gaacgagctc caacggcatg gtagctgacc aagtcatcca ccaagatcag atttgacgga
     5821 taaagcatct catctgccgt tgtcaaacca gtctctgtaa tcacgcggta gtgcaactgg
     5881 cgcacagcct gcaagccgtt aatcaggctt ggagccttag aagtatctgg ctggtgaact
     5941 aatcctttat agccgtctcc attggtacga ggcttagcag tatacacgcg catgaccatg
     6001 aaaatcttat ccgctacctt cttttgcaag gcggataaac ggcgagcata ttccaagacc
     6061 gcctcttcat tatcagaaga gcaaggacca atcaccaaga gaatacggtc atcttcccct
     6121 gaaataatat ctgccaattc cctgtcacgg ctttccttga gtctcaaggc ttccgcagac
     6181 aattgggttt cagccttgat gacttccata tcgatttctt gacctttttc aataaatgcc
     6241 atcttattct cctaacgttt tgtaaatttc tctgacaaga gcttctgtgt tatcccaacc
     6301 caggcaaggg tctgtgatag acttaccaaa tacttctggc tcattttgtc gaccatcttc
     6361 cagataagac tcaatcataa aaccacgaac gaactgctta attttttcat tccaagcacg
     6421 gttaatcaag gtctggcgga caattcggat ctgttcaata tactgcttac cagaattgtc
     6481 atgattggta tcaatgatga taaaaggatt ttccaaaccc attttctcat actgggcaat
     6541 ggtatcaatt aaattgtcat aatagtagtt gggaatattt tttccatact cattaagagc
     6601 accacgaaga atagcgtgtg aaagcgggtt cccagttgtt tctacttctt ttcctaagaa
     6661 aaggaaactt tgtttgtttt gagcagcata aatcccatta aacatgacat tgagatttcc
     6721 agaggttgga tttttaaaac cagtagaaaa tcctgcccca cttgccacaa agcggtgttg
     6781 ctggtcttca actgaacggg caccaactgc catgtaagaa atcaaatcat ctacaagcgg
     6841 aaggttttca ggataaagca tttcatcagc agttgtcatc cctgtttctg tgatgacacg
     6901 atagtgaaga tggcgaacgg ctttgattcc attgataaga ctaggcgctt ctgtcgcgtt
     6961 aggctggtga atcaagccct tatagccatc tccgttggta cggggtttgg cagtataaac
     7021 acgcataacc ataaagatac gatctgccac ttcttcttgt aggactgcca aacgcttagc
     7081 gtattcaagg acagcttctt cgttgtcaga tgagcatggc ccgattacca agagaattcg
     7141 ctggtcttct ccacgtataa tggcttctag ctcttgatct cgctgtgatt tcctctccaa
     7201 agcctgacct tctaattttg acaaggcacg aacttcttct atatttattt tagagctttt
     7261 tgctgtaaat accataactc atctccttat aaagcaaacg gatacccagt aaaaatttac
     7321 ttttcacaag atatccgcct ctaaactatc tcattttatt gtcttttacc gtgacagttt
     7381 ttaaatttct taccagaacc acatgggcaa agttcattgc gtccaatctg gctcaaatcc
     7441 aaatcttctg gcatacttgc ttggtgagca gcgatattgc gagtcgctgt tgtactgata
     7501 tgacgttctg cctgtggtct ttcttgttca tgaatttgtg ctttcatcat caagcgtgtc
     7561 acatcaaact caatcgaacc aatcatatca ttaaacatac ggaaaccttc tgcctgatac
     7621 tcaacaacag ggttgttctg agcatagcca cgaagtccaa ccgcgttacg caattgatca
     7681 agggcatcga tatgatctgt ccacttgtta tccaccactc gtagaatcaa aactttttgg
     7741 aattctttaa ctgcttcttc atcgcgtagt tttgaaacct gactatcgta aaccttcaag
     7801 gcacgttgga aaagctcttc cttgatggcc ttatcagaca agcctgacaa gtcttccatc
     7861 gtaatagaat cttcaggaag caagttgtac ttagcgaagt tcaaaattgc ctctagtttc
     7921 tcatcttgtt tagcacgcgc atgaccgtca acgacacgac caatcgtgcg tttgatcatt
     7981 gcctgaattt caggtgccaa gtcacggtct gcagtaatga catcataacg ttgagtatag
     8041 ataatctcac gttgttcacg catgacatcg tcgtattgaa ggacttgttt acgggtatcg
     8101 tagttatttc cttcgacacg tttttgcgct gcttcaacct gacgcgtcaa catgcgagac
     8161 tcaatcgcct cttcagacat gttgagacgt tcaaagattc ccttcaagcg ttcagaacca
     8221 aaacgtttca tcaaatcatc ttcaagagat aggtagaatt gtgactcacc tggatctcct
     8281 tgacgacctg aacgtccacg aagctggtta tcgatacgac gactttcatg acgttctgta
     8341 ccaataacac aaagtcctcc aagttcacga acaccttcac caagcttgat gtcggtacca
     8401 cgacccgcca tgttggttgc gatggtaacg gcaccacgtt gaccagcatt catgatgatt
     8461 tgggcttctc tatagtggtt tttggcattc aagacttcgt gaggaacacc agctgcaacc
     8521 aatttcttag aaatgtagtc actagtttca accgctactg taccaaccaa gacaggttga
     8581 cccttttggt aacgagcctt aacgtcttcg acaaccgctt taaacttaga ttcgatactt
     8641 gcataaagaa ggtctgagtg gtcaatacgt tgaacaggac ggtttgttgg gattggaata
     8701 acacgaatgt tgtagatttc acgaaattct tcttcctcag tcttacctgt acccgtcata
     8761 ccagacaatt ttttgtacat acggaaaagg ttttggtacg tgattgaggc agatgtcttg
     8821 gtttcatcct ggattggcac accttctttg gcttcaatag cttggtgcaa tccatcagaa
     8881 taacgacgac cttccatggt acgacctgta aattggtcga caatcaagat ttcttgctct
     8941 tcgctcacca catagtcaat atcgagaagc atgatgtagt tggcacgaag ggcgttatcg
     9001 ataaagtggg tcaaagccac gttttcgatg tcatagaggt tttcaagttt gaagtagctt
     9061 tcagccctgt caatccctga atcagacaaa ccaatagtct tagactgcac atcgatgatg
     9121 tagtcatctt tgttcaaaga ttttacatag tggtctgcca tgtgatacaa ctgactggtt
     9181 tcaaccgcat tggcacctga tacaatcaaa ggtgtacgag cctcgtcaat caagatagag
     9241 tcaacctcat cgaccaaggc atagttaagc ggacgttgta ccatgttttc agcgcgaaca
     9301 accatattgt cacgaaggta gtcaaatccg atttctgagt tagttgagta agtaatatca
     9361 cactcatagg cttctttttt ctccattgga gatttggtag ccaagttaat ccctactgac
     9421 aaaccaagcc aagagtacaa ttcacccatc tcagtcgcgt cacgttctga caagtattca
     9481 ttaaccgtaa ctacgtgaac ccctttacct gaaagggcat tgaggtatac cggcatggtc
     9541 gcagtcaagg ttttcccttc ccctgtacgc atctctggca cgtcaccatg gtgaagaaca
     9601 atccccccca tgacctgaac cttataaggg aagagaccta ggacacgttt ggcaccctca
     9661 cggacaaccg caaatgcttc ataaagcaat gaatccagtg attctccatt ttgataacgt
     9721 tctttaaatt caactgtttt cgcttttaat tggtcatcag tcaaagcagc catttggtct
     9781 tcatatttga aaaccttgtc agccatcttt tccagacgac ggatttctcc tttatcattt
     9841 tcgataattg tttttaaaat attagccatg tttttcctta ctttaaattc cgaatatttt
     9901 agaatgttcc tttaatttta gcacaattac tgattatttt caaggaagaa tccccatttt
     9961 gaaaaggaaa aagaggttag ttttcaagct aacctctccg acttttatga ctgtttaatt
    10021 gccaaaaatc ggcaaaatgg caaatgtgat aaataagtta atccaaagag agagccagca
    10081 aatcagtcca aaaacaaaga gactgacttt cttggacagc aaggccatca aaatggacag
    10141 aattccaaaa actagcaaga ctttctgtat gatgaagatg tcaatcctta cccccagaat
    10201 cgctctatcc caagggataa agaagaaaga cagccagatc agcagaacta aaccaatata
    10261 aaccttggaa tagcgtgtaa taaatgattt tagatgtgcc ataagccatc tcctaggatt
    10321 gtatatcctt tacatattgt atatgtccat tttcgacaac taatacatct gtacaaaggt
    10381 ctgaaatatc ttccgatatg tgcgacgtca ggataaccag accattttct tttttcaggt
    10441 aagataaaat gacctgtttg gttaacctca cacttttctc atccaaagca ttcataggtt
    10501 catcgagaaa gagtatagaa ggagaggaaa taaaggcttg aatcaaggcc attttttgct
    10561 ttgttcccaa ggataaatga cggtattcaa catcttcaaa ttcctgtaaa tcatagtatt
    10621 gaatccaata ggcaattctt ttttccgtaa ctttagatga aaaatacctt aacagttcca
    10681 aattttctct cagggataaa tgagataaaa actcgacttt ttcaattaaa attcctgcat
    10741 cctgaatata atgatttttt accccgtaaa ctttaccatc ttgaagaact tttcctttgt
    10801 caagcttaat ataaccagca agtatcttta aaagaaccgt cttgccagat ccattatcac
    10861 ctttaagtcc ataaattttt cctgattgaa acaccaaatt caactgattt aaaataggtc
    10921 ttttcccata aattttctgt ccatttataa tttcaagtct catcgtttat cctttcttaa
    10981 atttctcttc caagcgacta agaatcaaca taactaataa gcttaagagt actaaataca
    11041 ctgttacaat atgatccatc atccattctt gtcccacaaa tgctaaaaaa tagagaaaaa
    11101 aggaaaaacc agcgcccgca ctaatcagtg ctatcagata agacagtagt aagtacaaca
    11161 tcattaactg agcaagtaaa aagaaaagtg cgactgtttt gaaatgaatt cctagaggaa
    11221 gtaaaccaag aaaccagaca aacaaatctt gagtaaaaaa tttagaaatg acaaccaatc
    11281 gtttccttgt ataatcgaaa aaggagcttg attgatagcg aatcaagtga tggtaatggt
    11341 ctgccaaatc actttcaagt aaaatgacag agagccatcc taccatgaaa agcgaaaggt
    11401 ttaacaagag tttggggatt tctaaattcg cttcagaata gtcattatag gaaaaaattg
    11461 aaatcaattc tctcttgaaa aagataacag catcctgctt ttgaaccgct gttgacaata
    11521 gatggtttat caaaatcatc atcagaacta tacgaagtag taaaacaatc tttctcttta
    11581 gccaaatatt gttaaaattc ttaaacatta tcttcatatt tttcaagcac catgtaaggg
    11641 acaatataaa ggatataagg agtaaagagt ttcatcaaac ttacatcccc atagctagct
    11701 tgcatcaaac tcgtcatagg aaccatatag taaggcaagg cactatagag cagcatagaa
    11761 ccaagccaaa gaaacatcaa ataggtgatt gccgaacgag tcacattccc cacataatca
    11821 actatttgta aaaaatagat tgcattgatg aaaataccga ttagtaggac acaagtaaag
    11881 aacaaatagc tttttatctc tccatctagg agtctttgta aaccacttcc atcagaaaat
    11941 agagaattcc atccaagagg agaaaaagtc ccaaagaaat aggttacaat tgcaattatc
    12001 agcacagtca ctaaatatat caaacaaggg atacttgcaa cttgcaaagt caactttctt
    12061 tttaaccctt gataactcac ttctcttcca atactcaatc gtaaaacttt atttttcagc
    12121 tcaatatatt gaaaacctag caaaacaatg atgattggaa taataaatga ttgataaaaa
    12181 cctagattga actggagaat acgaaaatct aatgctgatt ttaataagtc atttttaatt
    12241 gcttgtccat cgaatttagc tagatcgggc gcatgaatat caaaaaagaa ataagtcatc
    12301 aaaacatcac gataaaccaa agcaagaaaa agcaaagtaa gcaagacata aacaaattta
    12361 tgccttgcca aagttaagag aggaatcttc ataagcaacc tcctacaaat agaaagtaat
    12421 ataatactca atgaaaatca aagagcaaac taggaaacta gccgcaagtt gctcaaagca
    12481 ctgctttgag gttgtagata agactgacga agtcagttac atatataatc caaggcgacg
    12541 ttgacgtggt ttgaagagat tttcgaagag tataaatcaa tgccttccgc ctttagactt
    12601 ccctagttcc cgtctcaagt caagcatttt tttgaaacag atatagtcta accagccact
    12661 agcaaaagcg ataagtagta ataatagcca aataccccat aacttgatat ctgtcaaatt
    12721 tctcaagacg atattgaaaa acagaactga aaaaactgtc caagcaaggc taaaaagagc
    12781 atagagggtg atgtaaatcc agtaaaaata gtaaaaaatt gggaaaatct tactatctct
    12841 gtttgccttt tcaatccagc tgaaaaagta aaaacagggt aataagatta tcattttaaa
    12901 caagtattcc atcacaaacc tcctctttta aattgttttc tttagtttcg ttctattaaa
    12961 tgttattacc aatataaacc ttggaatagc gtgtaataaa tgattttaga ggtaccataa
    13021 gccacctcct acaaatagaa accgatataa atcaatgcct tccaccctta gacttcccta
    13081 gttcctgtct caagcgaaac atttctttga aacaggaata agttaaccaa ttcataccaa
    13141 tagctagcag aataaaaaga aaccaaatgc cccataactt gatatctgtc acatttctca
    13201 agacggtatt gaaaaacaga actgaaacaa ctgtccaagc aaggctaaaa agagaataga
    13261 aggggatgta aaaccagtaa aaataataaa aaattggaaa aaacttacta tttctgttgg
    13321 ccttttcaat ccagttatca aaataaaagt acggtgctaa aagtaagaat ttaaacaaat
    13381 gttccatcac cgacatcccc cttcttttga tagcgttttc tatcatttta ttatatcaaa
    13441 aaaatccgga actgtcattc cagattctaa ttttttattt gcgttttctt gcgatgagat
    13501 gaatcggtgt tccctcaaaa acaaaggcct tgcggatttg attttccaag aaacgcaggt
    13561 aagaaaagtg catgagttct tcttcattga caaagatgac aaaggttggt ggtttggttg
    13621 ccacttgggt cgcatagaaa atcttgagac gttttccttt gtctgtcggt gttgggttga
    13681 tggcaatggc atccatgatg acatcgttca agacagctga tggaatacgt gtattttgac
    13741 tttcgctgat ttgcttaatc atctcaggaa gtttgtggag acgttgcttg gttaaagctg
    13801 atacaaagat aatcggtgcg taaggcaggt attggaactg ctcacggata tcttcttccc
    13861 agtttttcat agtgtggtta tctttttcaa gcgtatccca cttgttgacc acgataatca
    13921 tccctttacc agcttcatgg gcaaatcctg cgatacgctt gtcgtactca cgaatgcctt
    13981 cttccgcatt gatgaccatc aagaccacat ctgaacggtc aatagcacgc atggcacgca
    14041 taacagagta tttctcagta ttttcataaa ccttaccaga cttacgcata ccagccgtat
    14101 caatcatggt aaactcttga ccatctgtat ctgtaaagtg ggtatcaata gcgtcacgag
    14161 ttgttccagc aacaggactg gcaataacac ggtcttctcc caagatagca ttaatcaagc
    14221 ttgattttcc aacgttagga cgaccaatca agctaaactt aatgacatct ggattttctt
    14281 cttcatattc atttggaagg ttttccacaa tcgcatctag tacatcccct gtaccgatac
    14341 catggacaga tgagataggc agtggttcac ccaaaccgag agcatagaaa tcatagatat
    14401 catttctcat ctcagggtta tccaccttgt tgactgcgag gataactggt ttgtgggtct
    14461 tataaagctt gcgggctacg tattcgtctg catcggtaat tccttcctta ccggacacga
    14521 caaagacgat aacatctgct tcttccatgg caatttctgc ctggtgcttg atttgttcca
    14581 tgaaaggagc atcgacatca tcaattcctc ctgtatcaat catgctaaaa gaacgattga
    14641 gccactcacc cgttgcataa atacggtcac gtgtcactcc ttcgacatct tctacaatgg
    14701 agattcgctc accagcgatc cgattaaata gggttgattt cccaacattg ggacgtccta
    14761 caatggcaat agttggtagg gccataattt ctcactttct acaataattt cttctgttca
    14821 agattttttc tagttgagct tggttcagct tgaccaaact gttctgctag gcgctgactc
    14881 cagcttgtgg tcgcacgcgc cccagcatag tcagcctgaa cacggtcata agcttggatt
    14941 gcctcagttg actgttcttg gtattcttcc tcaaagacaa cattctctag tggcagtctc
    15001 ggtttcatat catgatgttg atttggcaca cccagtgcca tcccaaagac agaataggtg
    15061 tagtcaggca ggttaaagag ctctgccact tcttcagact tgtatcgaac caaaccgata
    15121 atcacaccac catagcccaa gctttcagct gccaacaagg cgttttgtcc agcaagagct
    15181 gcatcgaccg aactaatcaa gagaccttcc acaccttggg gttggaaggt gtcggtatga
    15241 agtcgggctc ccttttctgc tcggttcaaa tctccgacaa agagaaggaa aacagcagac
    15301 tggcgaatgg cttcttgagg taccaattca tacaaggcat ctttcttctc ttgacttcat
    15361 accacaatca cagagtagga ttggaaattc ttccaagatg atgccatctg ggctgctgtc
    15421 aaaatctcat ttaagtctac ttggggaatt tcttgctctt taaacctgcg cactgaagta
    15481 tgagccttca tcaatttaat ggtttctgtc atcgacggtt tactccttct aaacgagtct
    15541 cctcagccaa ataacggatg cgttccatga cccgtctggc ttcccaggtt tcgtcatttc
    15601 catgtttcac tttcgcaaaa tgcttctcca aatcttcaaa gttgaagttg gatgtgaaaa
    15661 aggtcggtaa attttcctgc atccgatatt ggagaatgac ctgcaggatt tcgtcacgca
    15721 cccaaacggt tgattgctcg gcgccaatat catctaaaat caggacctca gacagcttaa
    15781 tctcatccac caaggtctta acattgccat cactgatagc atttttgaca tcaatgacaa
    15841 agctaggata gtggaggaga gttgatgaaa caccacgttt ttctgataaa tcatgagcta
    15901 aggccgccac catgaaactt ttacccacac caaagtctcc atataagtaa agaccttttc
    15961 gaatagctgg atattgctcc acgaaggcta gtagcttttc aaaaactggt aagcgcccca
    16021 aatcatccaa gtcaacttga gccaaactag ctttcttgag actggctggt agattgatta
    16081 acttgagacg gttcttaata gccgcttctt tttcagccgc gattagctca ggagtttctt
    16141 catatgaaac atctgcatag ccatgattct taaccaaaat cggcttgtag cctttggcaa
    16201 tataatccgt atccccacgg agaaacttgt cacgctcggt gatgtactga ttaaacttgg
    16261 agatactgcg atttaattcc tctggagtca aggattcttg ctggataaaa gccgcaacat
    16321 cagggtcctt catgattttc tggaccaaat cttgataata aaaacggctg ggttgacgtt
    16381 tgagtacgtc tccgacactt tccatctaat ctcctccttt ttctaatcga gctaatagtt
    16441 cttgcttctt acgttctagt tccagacgag tttcctcgct ggtttcattc ttatattcag
    16501 gattactcca tttaggaaca ttggttttta ctggggcagt ctgattctgt ttttgtgttt
    16561 ttgctttctg tcctcgctca cggatgcgca agactgcctt ttctgccgaa tgaatctttt
    16621 gataggcata gtcattggct accttcatgg catatttctc attgatattt gccgaatcga
    16681 ccttattaaa ggtcaataaa agaatgatat tgatgacttc gtccagcaag cccaagccag
    16741 ccatctgttg caagagttct ctttctgttt gggtaatggt tcccttgcgt gtttgcttga
    16801 tttctgccaa gaactgcagg gcagttttac ttttggcttc tttgataatg gttgtttcct
    16861 taagactaaa gtcagaggaa actggttttt gagcaatttt ttcacgcatg cgtttggttg
    16921 aaataacctg agaaacagct gttgacttgg ccaattgata ggtttcaaac caagtccatt
    16981 tcttctcctc ggcaatagca aagaggttta agacatcgga ctgctcatcc gcaaaacgaa
    17041 gtccatctcg agccatcagc tggcgaaaat gttccaagtc aaaatcattg gccactttct
    17101 tcttgagacc aaggtcttct tgactgccta gttctgccaa ttctggaaag acttgattga
    17161 gtgagacagg tatttcttca ccatcagcac tttcaacttt caaatcctcc acagcagagt
    17221 cgccaatctt tttctctaag agtctgcgat aaacaggatg ctccaagaag tcttgactag
    17281 atagaggagc atggagggct agctgataaa catccccctt ttgatagagg gtcaagagat
    17341 taaaagcaga taagattttc aatgatttta tcagtctatc catcccaaag ttgagatgat
    17401 tgaggatact tgaaaaaaga tattcctttc taccattatc ccaaaaactg attgtataaa
    17461 gataaaggct cagtgcctcc tgaccgataa tcgggaggta gcactgtacc agagatgagg
    17521 tatcttgcga cacccgatta ttctttagat aagaaaaacg gtcaattggc ttcatttatc
    17581 tttccttttt ctttttagag gactgggtga tttgttggag caagctctct aactcactga
    17641 catccttaaa actacgatag acactagcaa aacgtacata ggtaatctcg tccaattcag
    17701 ccaactcctc catgacgagt gaaccaatgt cctcactttg aatttcattt tcatttcgac
    17761 cacggagttt ctgttcgata cgattgacta ccatgttgat ttcatcactt gacacaggac
    17821 gtttctgggc tgagcggata atcccattaa agattttatc tctggagaat tgttcccgtg
    17881 taccatcttt tttaacaacc actaaggttc tttcttctac tcgttcgtag gttgtaaaac
    17941 ggtgttggca ttcgtcgcac tcacgtcttc tacgaatggt gttcccttct tctgcttggc
    18001 gactatcgat aacacttgac ttggtagccc cacattttgg acaacgcatc ctttccctcc
    18061 ttatcgtttt cttttcatta taccattttt taagcgattc ccaaaacaat tcttcttttt
    18121 gcttgacaag ttttttgttt tgttgtatta tttaattaag acaaaaggat aagagaaagg
    18181 agactaagat gtcctggaca tttgacaaca aaaaacccat ctatttacag attatggaga
    18241 aaatcaagct tcagattgtt tcccatacac tggaacccaa tcaacaactt ccaaccgtga
    18301 gggagctagc tagcgaggct ggtgtcaatc ccaataccat ccaaagagcc ttatcagacc
    18361 ttgaacgaga aggatttgtc tacagcaagc gaacaactgg acgatttgtg actaaggata
    18421 aggagctaat cgcccagtca cgcaaacaat tatcagaaga agaattggaa cacttcgttt
    18481 cctccatgac ccattttggc tatgaaaaag aagaactacc aggcgtagtc agtgattata
    18541 ttaaaggagt ttaagcctat gtcattacta gtatttgaaa atgtatccaa atcatatgga
    18601 gcaacaccag cccttgaaaa tgtttctctt gacattccag ctggaaaaat tgtcggcctt
    18661 cttgggccaa acggctcagg aaaaacaacc ctgattaaac taattaatgg cctcttacaa
    18721 ccagatcaag gacgtgtcct catcaacgac atggacccaa gcccagcaac caaggccgtt
    18781 gtagcttatt tgcctgatac gacctatctc aatgagcaaa tgaaggtcaa agaagcccta
    18841 acctacttca agaccttcta taaagatttc aatcttgaac gcgcccatca tctacttgca
    18901 gacctgggca ttgatgaaaa tagtcgtctc aagaaactat caaaaggaaa caaagaaaag
    18961 gttcaactga ttttggttat gagccgtgat gctcgtctct atgttttgga cgaacccatt
    19021 ggtggggtgg atccagcagc ccgtgcttat atcctcaata ccattatcaa caactactca
    19081 ccaacttcta ccgttttgat ttctacccac ttgatttctg atatcgagcc aatcttggat
    19141 gaaattgtct tcctaaaaga cggaaaagtc gtccgtcaag gaaatgtaga tgatattcgc
    19201 tacgagtcag gtgaatccat tgaccaactc ttccgtcagg aatttaaggc ctaagcaaag
    19261 gagattattt atgttttgga atttagttcg ctacgaattt aaaaatgtta acaagtggta
    19321 tttagccctc tacgcagccg tgctagtcct ttctgccctc atcggaatac agacacaagg
    19381 ctttaaaaat ctaccttacc aagaaagtca ggctactatg ctactttttc tagctacagt
    19441 ctttggtggc ttgatgctta cacttgggat ttcaaccatt ttcttgatta ttaaacgctt
    19501 caaaggtagt gtctacgacc gacaaggcta tctgactttg accttgccag tttctgaaca
    19561 ccatatcatc acagccaaac taatcggtgc ctttatctgg tcattgatta gcaccgctgt
    19621 attggctcta agtgctgtta ttattctggc tttaacagct ccagaatgga ttcctctttc
    19681 ttatgtgatt acatttgtag aaacacatct ccctcagatc tttcttacag gtatatcctt
    19741 cctactaaat actatttcag gaatcctctg catctacctg gctatttcca ttggacagct
    19801 tttcaatgaa taccgtacag cactcgctgt tgcagtctac attggtatcc aaatcgtcat
    19861 tggatttatt gaacttttct tcaatcttag ttctaatttc tatgtcaatt cactggtagg
    19921 actcaatgac catttctata tgggagcagg tatagccatt gttgaagaac tcatattcat
    19981 agctatcttt tatctcggaa cctactacat cttgagaaat aaggttaatt tgctttaaat
    20041 aatttttacc tagatatgta acatactcat agaacaaaag agaccaggca aaaagtcttt
    20101 aaaattagaa aacgcatagt atcaagtgtt aaaaatcctt gatattatgc gttttttgtg
    20161 agttgactta tttcctttca ctatatcgca aaatgaaata agaacggaac gatgggattt
    20221 tggaattcaa atcaatttgt aagaatgttt tagaagtaat attatcctat tccagattca
    20281 gttcactata caattgagtt ttcaagcaac ttgtttacat aatgtgtaca taattaggtt
    20341 cgtgattcca cccttttcac ctttaaaaac ctcgctttcg caaggctctt ctatttataa
    20401 gataaggcac gtttaaaggt tttccaaatc cctaaatcat ccgtttgaag aacgagacta
    20461 gcatacatgc gtccgataaa tcctgttgct accaccgcaa aaatcactgt aatagcaagt
    20521 gaaatccatg cttccgctcc ccccgcatag ccattaatcg ttcgaaacgg cataaagaag
    20581 gtcgaaataa agggaatata agaaccaatc ttcaagagga gattgtcacc agctgcacct
    20641 agagctgtca ctccaaaaaa accacccata atcaaaatca tcaaaggcga caaggctttc
    20701 cctgagtcct caggacgaga aaccatagat cctaggaagg ctgccaagac tacatacatg
    20761 aaaagactga tcaaaataaa gagcagggta ttcagtgaga tagcatctcc caagtgatcc
    20821 aaaataccag actgagccaa gaatggcaaa tctttaaaga gcaaaacggc agccagacca
    20881 cctacaacat agatcccaat atgcgttaaa atcactagaa acagagccat catccgcgca
    20941 tagaaatagt gacttgccct tatgctagaa aaaacgactt ccataatttt ggtgcctttt
    21001 tcactggcaa cttcctgagc tgttacaccc gcataggtaa tcagaatcat ataaagaaag
    21061 aatcctaagg cacctgctgc aattgtttga ataaactttt tattttcctt ggcttcatca
    21121 atcttttctg tgaattgaat tgtctgcgct aagcgttttt cctgctcttg agacaaggaa
    21181 gcagttgaac gattaagctg attttgcagt tcattgagtg tacctgtaac ctcaaattta
    21241 attccatttt caagcgatgt ttcgccatga taaactgcct ttagaacact atcttcttga
    21301 tcaatggtca aataaccttt taatttttct tctttaattg cttctttggc acttgcttcg
    21361 tctttatagt cgaagttaac accatttaca ttcttcagtc cttctgctac agatggcact
    21421 gttgtcacta ctgccacttt attattttta gccatagaag aaccttggag atgcccaatt
    21481 cctacagaga ttcctaaaaa gaggaacggc gaaatcacca taaagaagaa actccatgac
    21541 tcgacatgtc gaagataggt ttccttgatt acaacccaca tatttctcat acttccactc
    21601 ctgattctag tttaaagatt tcatcgatag ttggcgcttg ttggtcaaat gttgcgatat
    21661 attgaccttg agtcaagatt gggaagagtt cccttccagc gctctcatcc tccaaaatca
    21721 atttccaact gccttgtttg gtcaagctca cctgtttgac atgaggaaga ttttccaatt
    21781 cttccttgct tcgttcactt gaaacaaaga gacgcgtttt cccgtattga ttgcggacat
    21841 cctgaactgg tccgtgcaag accacacggc catctcggat catcagaata tcgtcacaaa
    21901 gttcctcaac attggtcatg acatggtcag aaaagataat ggttgctccg cgctcttttt
    21961 cctgaaaaat gacttgtttg agcaattctg tattaactgg gtccaatcca ctaaaaggct
    22021 catccaagat aatcaggtct ggttcatgaa tcagagtaat aatgagctga atcttctgct
    22081 gatttccttt tgacagactc ttgattttat ctgtcagctt tcctttcact tccaacctct
    22141 tcatccattg agggagtttt tctttgactt ctttggcatc catgcctttt agagtcgcca
    22201 agtagcgaac ttgttcaaga actgtcaatt taggcatgag actgcgttct tcaggcagat
    22261 aaccaatccg agcataggtc tcctgacgaa tatcctgacc atccagaccg atttctccct
    22321 gatattctag gaatttcaaa atactatgga aaatcgttgt ttttccagca ccattttttc
    22381 cgactagtcc caaaatacga cctggtcgcg cttgaaagtc aataccaaac aaaacttgct
    22441 tggatccaaa acttttctct agacttctta cttctagcat ctttcacctc cgaaatttct
    22501 ttcactcatt atactccttt ttgatagcct ttacaatgat ttctgtccat ttttagaaga
    22561 ctattgctgt gtaaaatata gcctggagca cttttatact caatgaaaag caaagagcaa
    22621 actaggaagc tagtcgtagg ctgctcaaag tacagctttg aggttgcaga taaaactgac
    22681 gaagtcagct caaaacactg ttttgaggtt gtggatagaa ctgacgaagt cagtaactat
    22741 atctacagca aggcgaagct gacgtggttt gaagagattt tcgaagagta ttagtgataa
    22801 atccattata cagtagcaaa ctcaatttat accttccgct cctcaactgt ctatttttaa
    22861 tcctgaattg ttatttgagt aactcctttt tcctcataaa gttttcttcc tctaaaactt
    22921 ctggaaaaag gcgaatagtt tcagacaaca tttttataag aaacaagttc atctgtcatt
    22981 tcaagaagga gtaatccttt atttactaat ggacggaacg gaattcaacc gcttgtccga
    23041 tatgttttct aaggattata tagtaaaatg aaataaaaac aggacaaata gatcgggaca
    23101 gtcaaatcga tttctaacaa tgttttagaa gtagatgtat actattctag tttcaatctg
    23161 ctatatctat tatgcacacc cctataggat ctaatgaaaa tcacaacagg ctcattcata
    23221 gatggttacc taagcctaag ggaactaaga aaacgactac aaaggaagtc gcattcatcg
    23281 aaaagtggat taacaactat cctaaaaaat gcttgaacta caagtccccc agagaagact
    23341 tctggatgac taacttgaac ttgaaattta gcaataatta attcaccatc taactatatt
    23401 tagtaattat ttcagaactg attaatatta aaattaacta acgattcaaa ggattcatac
    23461 tagccataaa ttacgtccat cagagagaga ctcttactac ttttagattt tagtctttct
    23521 agcttcagaa tacatctaaa ctttagggaa aatgactatt cgaaagcgcg aatgcctcaa
    23581 aattatctca gataagctat tcgaaactta gaatgctttt aaatttatgg aattgcgatt
    23641 attcgaaacc tagaatgcat ataaccttta gttgacagac ctattctaag tctcgaaggg
    23701 ctatttactt tctattcctt atcaaaaaag actcattccc cctttctcct ccaaaatatg
    23761 gtatagtaga aatatactat ctatgaggag tttacatgtc acaggataaa caaatgaaag
    23821 ctgtttctcc ccttctgcag cgagttatca atatctcatc gattgtcggt ggggttggga
    23881 gtttgatttt ctgtatttgg gcttatcagg ctgggatttt acaatccaag gaaaccctct
    23941 ctgcctttat ccagcaggta ggcatctggg gtccacctct ctttatcttt ttacagattt
    24001 tacagactgt cgtccctatc attccagggg ccttgacctc ggtggctggg gtctttatct
    24061 acgggcacat catcgggact atctacaact atatcggcat cgtgattggc tgtgccatta
    24121 tcttttatct ggtgcgccta tacggagctg cctttgtcca atctgtcgtc agcaagcgca
    24181 cctacgacaa gtacatcggc tggctagata agggcaatcg ttttgaccgc ttctttattt
    24241 ttatgatgat ttggcccatt agcccagctg actttctctg tatgctggct gccctgacca
    24301 agatgagttt caagcgctac atgaccatca tcattctgac caaacccttt accctcgtgg
    24361 tttataccta cggtctgacc tatattattg actttttctg gcaaatgctt tgacacgtaa
    24421 aaaatccgtt tggtttccca agcggatttt taaagcgtag attaactata gcttgatact
    24481 aaatatactt tggtatggaa attatgcata tttttcgata gtgaggcgag gacttaccta
    24541 gcctttccgc cgtgatagaa acacctgaaa tctaatggtt tcaggtgttc ggaaactttg
    24601 agacattagg atcaaagttt aggtatggaa tttcgaagaa agtcgctacc gtccgtaatc
    24661 acttaaggaa aggctcaaaa atattgtttt caaccacaaa atccgtttgg tttcccaagc
    24721 ggattttgtg ctttattttg aaacttcttt tgcaagaaca aagttcccaa gtgtggcaga
    24781 accatttcct gcgactgctg gcgtcacgat atagtcacgc acatctggta ctggtaggta
    24841 accattaaga agagatgtaa atttctcacg gacacggtcc agcatatgtt gttgagccat
    24901 gacccctcca ccaaagacaa tcacgtctgg gcggaaagtc actgtcgcat taaccgcagc
    24961 ttgagcgata tagtaggctt gaacatccca aacagggttg ttgagttcaa tagtttcccc
    25021 acgtacacct gtacgagctt ccaaacttgg accagctgca taaccttcta gacatccctt
    25081 atggaaagga caaacaccct taaactcttt ttcaatatcc attgggtgtc tagcaacata
    25141 ataatgaccc atttcagggt gacccacacc accgataaac tcaccacgtt ggatgacacc
    25201 tgcaccgata cctgtaccga ttgtgtagta aaccaagttt tcgatacgac caccagcatt
    25261 gttacgggca accacttcac cgtaagcaga gctgtttacg tctgttgtga agtacattgg
    25321 cacgtttagg gcgcgacgaa gggcaccaag caagtccaca tttgcccagt ttggttttgg
    25381 agtcgtcgtg ataaagccat aagtttttga gtttttgtca atatcaatcg gcccaaatga
    25441 accaactgca agaccagcaa ggttatcgaa ttttgagaag aactcaatgg ttttatcgat
    25501 tgtttcgatt ggagttgttg ttggaaattg tgttttttct acgacgttaa agttttcatc
    25561 accgacagca cagacaaact ttgtaccgcc cgcttccaag cttccatata attttgtcat
    25621 gataaacctc ttgtttttat tttctttatt atagcatact tcgaaagtct aaatgtctct
    25681 attttttaga ttttcctctg taaatcttac tatctaataa aaacgaacaa acatgtcatt
    25741 tgttcgtttt cacattagag aggattgatt agattttcac ttcgatcaca gcatccccct
    25801 tcgcaactga acctgttgcg actggagcta ctgaagcgta gtcagctgta tttgtaacga
    25861 taaccattgt tgtatcatca agtccagctg cagcgatttt gtttgagtca aatgttccaa
    25921 gaacatcacc agctttcacc ttattacctt gagcaacttt tgcttcaaaa ccgtcaccgt
    25981 tcatagatac agtgtcaata ccaacgtgaa tcaaaacttc agcaccattt cttgttttca
    26041 aaccaaaagc gtgccctgtt ggaaaggcaa ttgaaacttc agcatcagct ggtgcataga
    26101 ccacgccttg gcttggtttc acagcgatac cttgtcccat agctccactt gagaagactg
    26161 ggtcattgac atcagcaaga gcgacaacat caccgacgat aggagttaca agtgtttcat
    26221 tttgaagagc tgctggcgca acttcttctt tttcttcagc cacttcagct tgttttgcag
    26281 ctgcagttgc gtctacttca tcttcgtaac caaacatgta agtaagagca aaaccaaggg
    26341 caaatgatac agctaccata agaaggtatt gtggaagttg tccgttacca acataaagca
    26401 ttgtaccagg gatgatggtg ataccattac cagtaccagc aagtccaagg atagaagcca
    26461 atccaccacc gattgcacca gcaatcaatg aaaggaagaa tggtttacgg aagcgcaagt
    26521 tcaccccgaa gatagcaggc tctgtaatac ctaggaaagc agaaagagca gccgggaaag
    26581 caagtgtttt cagttttgga ttttttgttt taacaccaac cgcaacagta gcagcacctt
    26641 gagctgtcat agcagctgtg atgatagcgt tgaatgggtt agcatggtca gcagcaagta
    26701 attgcacttc aagcaagttg aagatgtggt gcacacctga cacgacgatc aattggtgaa
    26761 ccccaccaat caagaaacca ccaagaccaa atggcatgct aagaatcgct tttgtagcaa
    26821 taaggatgta gttttcaaca acgtggaaaa ctggtccaat gacaaagagt ccaaggatag
    26881 acatgaccaa aagtgtcacg aatggtgtta ccaagaggtc aatgacatct ggaacaacct
    26941 tgcggacagc tttttcaaat ttagctccga caaccccgat gatgaaggct ggaagaacgg
    27001 aaccttgcaa accaacaaca gggatgaaac caaagaagtt catcgctgtt acttcaccac
    27061 cttgagcaac tgcccaagcg tttggaagtg agccagagac aagcatcata ccaagaacga
    27121 taccaacggc aggatttcca ccaaatacac ggaaggttga ccacacaacc aaacctggca
    27181 agatgatgaa ggctgtatct gtcaagattt gtgtgtaagt tgcaaagtca cctggaagtg
    27241 gcatttcaag agcgttgaaa agaccacgca cacccatgaa gagacctgtc gctacgataa
    27301 ctgggatgat tggaacgaaa acatcaccaa aagtacggat agcacgttgg aaccagttcc
    27361 cttgtttagc aacttctgct ttcatgtcat ccttagatga tgttggtaat ccaagtacaa
    27421 caacttcatc gtacattttg ttaactgtac ctgtaccaaa gataatttgg tattgccctg
    27481 agttaaagaa agcaccttga actttttcca agttctcaat cacttcttta ttgattttct
    27541 cttcatcttt gaccatgaca cgtagacgtg tcgcacagtg ggcaacacta ttgacatttt
    27601 cacgtccgcc caaggcatcg atgacttttt ttgcaatttc ctgattgttc atttgcaaaa
    27661 atctccttat ataacatttt gttcttgttt gaaagcgatt ttattcgccc ttacgactat
    27721 tattttatca tgttttaaaa atatgtcaag cgttttgcag aaaaaatatt ctatctactt
    27781 agtgggcaag ctttagattg attgtttttg actgtttcat caggaatttc ttgaaaaata
    27841 agtttgaaac cttggttaaa aagtctttta tttcattatc tttcacattt tcgtaaaaat
    27901 ttgattgatt tcctgtattt attttatgat aatcgtttga cagttttttc tcttttttaa
    27961 cataaagggc ttgcattttt tatcgaaaac agttactatt aaaagtgata agatttttgg
    28021 aggaatgaat ggaatggaca actgagcgtc gttacagact ttatcaagat tggacgcaag
    28081 aagaaattca acatataaag gaaaatatgg cacaatctcc atggcatact cattaccatg
    28141 ttgagccaaa aacaggactt ctcaacgacc caaatggctt ttcttacttt gatggcaagt
    28201 ggatcctctt ttaccagaat tttccttttg gtgcagccca cggtttaaaa tcttgggcac
    28261 agctagaaag tgatgatttg gttcacttta gagaaactgg agtcaaagtt ttgccagata
    28321 ctccattaga tagtcacggt gcctactctg gttctgccat gcaatttggc gataacttat
    28381 tcctatttta tacaggaaat gttcgcgatg aaaactggat ccgtcaccca taccagatcg
    28441 gtgctttgat ggacaaggag ggtaagatta caaagattga caagatcttg attgaccagc
    28501 cagcagactc tactgaccac ttccgcgatc cacaaatttt taactttaaa ggtcaatact
    28561 atgctgtcgt cggtggacag gacttggaga aaaaaggctt cgtccgtctc tacaaggctg
    28621 tcaataacga ctacacaaac tggcaagcag ttggcgacct tgactttgct aacgaccgta
    28681 ctgcctacat gatggaatgt cctaatctgg tctttgtaga ggaacagcct gtccttctct
    28741 actgtccaca aggattggat aagaaagttc tagactacga taatatcttt ccaaatatgt
    28801 ataagattgg ggcttccttt gaccctaaaa atgccaaaat ggtagatgtg tctcaacttc
    28861 aaaacatgga ttacggtttc gaagcctatg caactcaagc cttcaacgct cctgatgggc
    28921 gtgctctagc agttagctgg cttggtttgc cagatgtttc ttacccatct gaccgttttg
    28981 accaccaagg aaccttctct ttggtcaagg aactcactat caaagacgac aagctctacc
    29041 agtatccagt cgctgctatt aaggaccttc gtgcttctga agaagccttc tcaaaccgtt
    29101 cccaaaccaa gaacacttac gaacttgaac tcaacttgga agctaatagc cagagcgaga
    29161 ttgtcttact tgctgataaa gaaggtaagg gactttcaat caactttgac cttgtaaacg
    29221 gtcaagtgac agtggatcgt agccaggctg gagaacagta tgcccaagaa tttgggacaa
    29281 ctcgttcttg ccctatcgag aatcaggcta ctactgctac aatcttcatc gataactctg
    29341 tctttgaaat tttcatcaat aaaggagaaa aagtattttc tggtcgtgtc ttcccacatg
    29401 cggaccaaaa tggtatcctg atcaaatctg gaaacccaac tggaatttac tatgaattag
    29461 attatggtcg caaaactaac tgatgtcgcc aaacttgcag gcgtcagtcc tactaccgtt
    29521 tctcgggtta tcaataaaaa agggtatcta tctgagaaaa ccatccaaaa agtcaatgaa
    29581 gccatgagag aattgggcta taaacccaac aacctggctc gtagtctgca aggaaaatca
    29641 gctaagttaa tcggcttgat tttccccaat atttccaatg ttttctatgc agaattgatt
    29701 gataaattgg aacaccaact cttcaaaaat ggttacaaga ccatcatctg caacagtgaa
    29761 catgattctg agaaggaacg cgaatacatc gaaatgttgg aagccaatca ggtagacggc
    29821 atcatttctg gtagtcacaa cctaggaatc gaagactaca atcgtgtgac agcgccgatt
    29881 atttcctttg accgaaacct atcgccagac atccctgttg tctcctctga caactatgct
    29941 ggtggggttc ttgctgccca aaccttggtc aagacaggtg cccagtctat catcatgatt
    30001 acagggaatg acaattccaa ttcgccaacc ggactgcgcc acgctggttt tgcatccgta
    30061 ctcccaaaag ctcctattat caatgtttcc agtgactttt ctcccgtcag aaaagaaatg
    30121 gaaatcaaga atatcttgac ccgggaaaaa ccagatgcca tttttgcttc ggatgatttg
    30181 acagctattc tggtcattaa aatcgctcaa gaattgggaa tttctgtccc aaaagagctc
    30241 aaggtcatcg gctatgatgg gacctacttt atcgaaaatt actaccctca attggctact
    30301 atcaagcaac ctttggaaga gattgcttgt ctcactattg atcttctctt gcaaaagatt
    30361 gaaggcaagg aagtcgccac aactggttac ttcttaccag ttacgctatt accaggaaaa
    30421 agtatttaaa cacaagaaaa ctcagaccga ttcgtctgag tttttatgat cttaaatttt
    30481 cgagatagcg ctgggctgtc tctaggttaa aggttttatc tgagatgagg cgctctacta
    30541 ggggagcaac ttcagattca ctagccccag ctaggagagc tagagatttg gcctgtagtt
    30601 tcatgtggcc ttgctggatg cccgtactta ccaaggcttt gagggctgca aaattttgag
    30661 caagaccgat ggacacgata atctgggcta attctctggc agaaggattt cctagtagat
    30721 catgactgag agctacacgt gggttgaggc cgatagagcc acccttagtc gctacaggca
    30781 tgggcagggt catctcaccg accaattctt ctctttcaag gtccagcgtc cagcagctaa
    30841 gaccttgata gcgtccatct cgactggcaa aggcatgggc cccagcttcg atggcacgcc
    30901 agtcattacc agtggcaatc aaaatcgcat caataccatt aaaaattcct ttattatgag
    30961 tagcagctcg gtaaggatca gcctgcgcaa actgactagc caacgcaatt ttctccgcaa
    31021 tctctcgtcc ttgatccttt tggcggctca agtagcgaaa ggccatgcga cagcttgcag
    31081 tcaccagaga atcagtcgcg tagttggaca ggattcccat gagactctgt ccctgactga
    31141 gttcttctaa gactggtttc aaggcttcca gcatggtgtt gagcatattg gcacccatgg
    31201 cttcctgggt atcgacatga atataaacaa cgagaaagtc tggttcgcct tttatctgct
    31261 cgacatgcag atcacgcgcc ccacctccac gtttaacgat agaaggatag gcttgattgg
    31321 caagctccaa gagctccgct ttcttgctgg caatcttctc ttgcgctagt ttaggattag
    31381 caacttgata aagggctacc tgcccaatca tctgtcgctg atggacttgt gcagtaaaac
    31441 cacctgtacg cttgatgatt ttgctggcat agctggccgc cgcaaccaca gagggttctt
    31501 ctgtcacata gggaacggtg tattcctgat cgttgacaag tacctccgga accagcgaat
    31561 aaggcagaga aaaagttccc accacattct cactcagctg gtctgccaca gtcacactca
    31621 tctgttcatc cttctccaga ctagcttgtc tctcaggact aaggagcgcc tgagctttta
    31681 acagctcgag gcgctcttgg tatgattttt tagaaaatcc attccaactt atcttcatta
    31741 tttttcaacc ttgctataac ggcgttggtg gtcgagaatt tcaaccaagg caaaatcttg
    31801 attttcatag ccagcaaact gggcagagtt tgtttcatcc aagtttactt cctcaaaaaa
    31861 gaccttttca tagtctgcaa cggatagggc agttcgttgg ttgagcttgt tcaaacggtc
    31921 tttatccaaa taagcttcat atccttcaac caattcacca ctgaagaact cagccacagc
    31981 tccacttccg taactataaa gggcgatttt atccccagct ttcaagctat ctgtattttc
    32041 caagagagac aaaagtccaa ggaaaagtga acctgtgtag atattcccca ccttttgact
    32101 gtagagaata gactggtcaa aatgcttttg taagaggtct tttttctctt gaggcaggct
    32161 cttatccatg atttttttca agccttttag cgctaattta ggataaggca agtggaaaca
    32221 aacagccgca aaatcatcca aagtaagctg gtagcgtttt tgatattcaa gccaagtcgt
    32281 tttcaaacta tccaagtatt gttgggtaga atagacacca tttacataag gagttgtcga
    32341 gtaatttggt cgccagaaat ccatgatgtc acgggtctga gctacattgt cattattaaa
    32401 ggccatcatg cgtggatttt gtgtaatcaa catagccaca cttccggcac cctgagtggg
    32461 ttctcccgga gtttcaatac cgtatttggc aatatcactt gcaatgacca agaccttgga
    32521 ctccggagaa ttttccacat gcaatttggc ataatggagg gcagcagtcg ccccatagca
    32581 ggcttcttta atctcgaaac tacgagcaaa gggctggatg cccagcaagc catgcacaaa
    32641 gacggccgca gccttactct ggtcaattcc tgactcggtc gccacaatga ccatgtcaac
    32701 ttcttgtctt tcttgctcag ttaaaataga gtcactagca ctggccgcca aggtcacgat
    32761 atcctcagtt aggggcgcaa tactcaattc cttgagtaag agtcctttac ttaatttttc
    32821 agggtcaatt cccctcgctt ctgctaagtc ttgtaatttc aagacatatt gactggtcgc
    32881 aaaaccaatc ttatcaatac cgattgtcat atttacctct gttttatcat tcatgtaaaa
    32941 aatcgttcta tactatttta tcacaaatgg cagtaaaaga gagaaaaaag acttgattca
    33001 ccaaatcaag cctcttattg gtcatcattt taaagaatga ttagttgcta gagagttcac
    33061 cgatataagt agctttataa gctccattca cagttatcag ctcctggagg atcaaatttc
    33121 ctgagtaagt ccttcccatc tcatctacaa atttttgata aaactgactg gtcggaattt
    33181 ctctgacatc cttatcaaat gtcttgtcaa gtgttttact aaccttctca gcaatcaatt
    33241 gatgctctta ccatccactt tgaaactctg agcccgaact agaaaccatg actgggataa
    33301 acaacaaggt cagtagattt acagacaata agtaaagtag tagacttcct gcaaaactag
    33361 aatcctagtt catgattgat aataccagca
//
LOCUS       DBERMM010000020        31560 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.020, whole genome shotgun sequence.
ACCESSION   DBERMM010000020 DBERMM010000000
VERSION     DBERMM010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 31560)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31560)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31560
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.020"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(1..314)
                     /locus_tag="ACL8AS_001191"
                     /pseudo
     CDS             complement(1..314)
                     /locus_tag="ACL8AS_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            642..2624
                     /locus_tag="ACL8AS_001192"
     CDS             642..2624
                     /locus_tag="ACL8AS_001192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1229057.1"
                     /translation="MKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETDP
                     DNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKDA
                     KWYTSEGEEYAAVKAQDFVTGLKYAADKKSDALYLVQESIKGLDAYVKGEIKDFSQVG
                     IKALDEQTVQYTLNKPESFWNSKTTMGVLAPVNEEFLNSKGDDFAKATDPSSLLYNGP
                     YLLKSIVTKSSVEFAKNPNYWDKDNVHIDKVKLSFWDGQDTSKPAENFKDGSLTAARL
                     YPTSASFAELEKSMKDNIVYTQQDSITYLVGTNIDRQSYKYTSKTSDEQKASTKKALL
                     NKDFRQAIAFGFDRTAYASQLNGQTGASKILRNIFVPPTFVQADGKNFGDMVKEKLVT
                     YGDEWKDVNLADSQDGLYNPEKAKAEFAKAKSALQAEGVTFPIHLDMPVDQTATTKVQ
                     RVQSMKQSLEATLGADNVVIDIQQLQKDEVNNITYFAENAAGEDWDLSDNVGWGPDFA
                     DPSTYLDIIKPSVGESTKTYLGFDSGEDNVAAKKVGLYDYEKLVTEAGDEATDVAKRY
                     DKYAAAQAWLTDSALIIPTTSRTGRPILSKMVPFTIPFALSGNKGTSEPVLYKYLELQ
                     DKAVTVDEYQKAQEKWMKEKEESNKKAQEDLAKHVK"
     gene            2925..8228
                     /locus_tag="ACL8AS_001193"
     CDS             2925..8228
                     /locus_tag="ACL8AS_001193"
                     /EC_number="3.2.1.97"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033926 -
                     endo-alpha-N-acetylgalactosaminidase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SpGH101 family
                     endo-alpha-N-acetylgalactosaminidase"
                     /protein_id="HGS1229058.1"
                     /translation="MNKGLFEKRCKYSIRKFSLGVASVMIGAAFFGTSPVLADSVQSG
                     STANLPADLATALATAKENDGRDFEAPKVGEDQGSPEVTDGPKTEEELLALEKEKPAE
                     EKPKEDKPAAAKPETPKTVTPEWQTVEKKEQQGTVTIREEKGVRYNQLSSTAQNDNAG
                     KPALFEKKGLTVDANGNATVDLTFKDDSEKGKSRFGVFLKFKDTKNNVFVGYDKDGWF
                     WEYKTPGNSTWYKGNRVAAPETGSTNRLSITLKSDGQLNASNNDVNLFDTVTLPAAVN
                     DHLKNEKKIFLKAGSYDDERTVVSVRTDNQEGVKTEDTPAEKETGPEVDDSKVTYDTI
                     QSKALKAVIDQAFPRVKEYSLNGHTLPGQVQQFNQVFINNHRITPEVTYKKINETTAE
                     YLMKIRDDAHLINAEMTVRLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERKLLSSISF
                     LGNALVSVSSDQTGAKFDGATMSNNTHVSGDDHIDVTNPMKDLAKGYMYGFVSTDKLA
                     AGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKE
                     LPSAKVVITEDANADKKVDWQDGAIAYRSIMNNPQGWEKVKDITAYRIAMNFGSQAQN
                     PFLMTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIE
                     KAKKYGAHLGIHVNASETYPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDAAYDLA
                     HGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGDNGAWATHVLAKEINKQGWRFAIEWG
                     HGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLL
                     GGYSMKDFEGWQGRSDYNGYVTNLFAHDVMTKYFQHFTVSKWENGTPVTMTDNGSTYK
                     WTPEMRVELVDANNNKVVVTRKSNDVNSPQYRKRTVTLNGRVIQDGSAYLTPWNWDAN
                     GKKLSTDKEKMYYFNTQAGATTWTLPSDWAKSKVYLYKLTDQGKTEEQELTVKDGKIT
                     LDLLANQPYVLYRSKQTNPEMSWSEGMHIYDQGFNSGTLKHWTISGDASKAEIVKSQG
                     ANDMLRIQGNKEKVSLTQKLTGLKPNTKYAVYVGVDNRSNAKASITVNTGEKEVTTYT
                     NKSLALNYVKAYAHNTRRDNATVDNTSYFQNMYAFFTTGSDVSNVTLTLSREAGDQAT
                     YFDEIRTFENNSSMYGENHDTGKGTFKQDFENVAQGIFPFVVGGVEGVEDNRTHLSEK
                     HDPYTQRGWNGKKVDDVIDGNWSLKTNGLVSRRNLVYQTIPQNFRFEAGKTYRVTFEY
                     EAGSDNTYAFVVGKGEFQSGRRGTQASNLEMHELPNTWTDSKKAKKATFLVTGAETGD
                     TWVGIYSTGNASNTRGDSGGNANFRGYNDFMMDNLQIEEITLTGKMLTENALKNYLPT
                     VAMTNYTKESMDALKEAVFNLSQADDDISVEEARAEIAKIEALKNALVQKKTALVADD
                     FESLDAPAQPGEGLENAFDGNLSSLWHTSWGGGDVGKPATMVLKEPTEITGLRYVPRG
                     SGSNGNLRDVKLVVTDESGKEHTFTTTDWPDNNKSKDIDFGKTIKAKKIVLTGTKTYG
                     DGGDKYQSAAELIFTRPQVAETPLDLSGYEAALAKAQKLTDKDNQEEVASVQASMKYA
                     TDNHLLTERMVEYFADYLNQLKDSATKPDAPTVEKPEFKLSSLASDQGKTPDYKQEID
                     RPETPEQILPATGESQSDTALFLAGVSLALSALFVVKTKKD"
     gene            complement(8394..10553)
                     /gene="pbp1a"
                     /locus_tag="ACL8AS_001194"
     CDS             complement(8394..10553)
                     /gene="pbp1a"
                     /locus_tag="ACL8AS_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001040003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP1A"
                     /protein_id="HGS1229059.1"
                     /translation="MNKQTILRIAKYVSICFLTLFITAVMLGGGIFLYYVSKAPALSE
                     SKLVATTSSKIFDSKNELIADLGSERRVNAQANEIPTDLVKAIVSIEDHRFFDHRGVD
                     TIRIIGAFLRNLQNNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAVQLEQK
                     ATKQEILTYYVNKVYMSNGNYGMQTAAQNYYGKDLRELSLPQLALLAGMPQAPNQYDP
                     YSHPEAALDRRNLVLSEMKGQGYISAEQYEKAINTPITDGLQSLKSVNSYPAYMDNYL
                     KEVIDQVEQETGYNLLTTGMDVYTNVDQEAQKHLWDIYNSDQYVSYPDDDLQVASTVV
                     DVSNGKVIAQLGARHQASNVSFGTNQAVETNRDWGSSMKPITDYAPALEYGVYDSTAS
                     IVHDVPYNYPGTDTPLYNWDHVYFGNITIQYALQQSRNVTAVETLNKVGLDRAKTFLN
                     GLGIDYPSMHYANAISSNTTESNKKYGASSEKMAAAYAAFANGGIYHKPMYINKIVFS
                     DGSEKEFSDAGTRAMKETTAYMMTEMMKTVLTYGTGRGAYLPWLPQAGKTGTSNYTDE
                     EIEKYIKNTGYVAPDEMFVGYTRKYSMAVWTGYSNRLTPIVGDGFLVAAKVYRSMMTY
                     LSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPAPQQPPSTESSSSSSDSSTSQSS
                     STTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP"
     gene            complement(10550..11146)
                     /gene="recU"
                     /locus_tag="ACL8AS_001195"
     CDS             complement(10550..11146)
                     /gene="recU"
                     /locus_tag="ACL8AS_001195"
                     /EC_number="3.1.21.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RecU"
                     /protein_id="HGS1229060.1"
                     /translation="MVNYPHKVSSQKRQTSLSQPKNFANRGMSFEKMINATNDYYLSQ
                     GLAVIHKKPTPIQIVQVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEAKETKQ
                     KRAIPMKNFHPHQIQHMEQILAQQGICFVLLHFSSQQETYLLPAYDLIRFYHQDKGQK
                     SMPLGYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR"
     gene            11212..11739
                     /locus_tag="ACL8AS_001196"
     CDS             11212..11739
                     /locus_tag="ACL8AS_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1273 domain-containing protein"
                     /protein_id="HGS1229061.1"
                     /translation="MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVS
                     WLVFTGSLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEGNQMKLSRFKQVDF
                     VKYAYPRYEHKGQLRDYQQFLLENTTSSYLFYDEENETKLAYFYQKMKNQEDYFIKRL
                     TFDELNELAENFSEN"
     gene            11809..12138
                     /gene="gpsB"
                     /locus_tag="ACL8AS_001197"
     CDS             11809..12138
                     /gene="gpsB"
                     /locus_tag="ACL8AS_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division regulator GpsB"
                     /protein_id="HGS1229062.1"
                     /translation="MASIIFSAKDIFEQEFGREVRGYNKVEVDEFLDDVIKDYETYAA
                     LVKSLRQEIADLKEELTRKPKPSPVQAEPLEAAITSSMTNFDILKRLNRLEKEVFGKQ
                     ILDNSDF"
     gene            12159..12539
                     /gene="rnpB"
                     /locus_tag="ACL8AS_001198"
     ncRNA           12159..12539
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="ACL8AS_001198"
                     /product="RNase P RNA component class B"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00011"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00011"
     gene            12624..13781
                     /locus_tag="ACL8AS_001199"
     CDS             12624..13781
                     /locus_tag="ACL8AS_001199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HGS1229063.1"
                     /translation="MKKKFNLIATVAAGLEAVVGREVRELGYDCQVENGRVRFQGDVR
                     AIIETNLWLRAADRIKIIVGTFPAKTFEELFQGVFALDWENYLPLGARFPISKAKCVK
                     SKLHNEPSVQAISKKAVVKKLQKHYARPEGVPLMENGPEFKIEVSILKDVATVMIDTT
                     GSSLFKRGYRTEKGGAPIKENMAAAILQLSNWYPDKPLIDPTCGSGTFCIEAVMIARK
                     MAPGLRRSFAFEEWNWISDRLIQEVRTEAAKKVDRELELDIMGCDIDARMVEIAKANA
                     QAAGVAGDITFKQMRVQDLRSDKINGVIISNPPYGERLSDDAGVTKLYAEMGQVFAPL
                     KTWSKFILTSDEAFESKYGSQADKKRKLYNGTLKVDLYQYFGQRVKRQEVK"
     gene            13794..15188
                     /gene="mapZ"
                     /locus_tag="ACL8AS_001200"
     CDS             13794..15188
                     /gene="mapZ"
                     /locus_tag="ACL8AS_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mid-cell-anchored protein MapZ"
                     /protein_id="HGS1229064.1"
                     /translation="MSKKRRNRHKKEGQEPQFDFDEAKELTVGQAIRKNEEVEAGVLS
                     EDSILDKYVKQHRDEIEADKFATRQYKKEELVETQSLDDLIQEMREAVEESEAYSEEV
                     PSSEDILPPLPLDDEEQGLDPLLLEDENPTEMTEEVEEEQNLSRLEQEESEKKSKKGF
                     VLTALALVSVIICVSAYYVYRQVNRSTKEIETSQSTTANQSDVDDFNTLYDAFYTDSN
                     KTALKNSQFDKLSQLKTLLDKLEGSREHTLAKSKYDSLATQIKAIQDVNAQFEKPAIV
                     DGVLDTNAKAKSDAKFTDIKTGNTELDKVLDKAISLGKSQQTSTSSSSSSETSSSSTS
                     QTSSNTTSETSPSSSNETRSSRSEVNMGLSSAGVAVQRSASRVAYNQSAIDDSNNSAW
                     DFADGVLEQILATSRSRGYITGDQYILERVNIVNGNGYYNLYKPDGTYLFTLNCKTGY
                     FVGNGAGHADDLDY"
     gene            15264..16688
                     /gene="gndA"
                     /locus_tag="ACL8AS_001201"
     CDS             15264..16688
                     /gene="gndA"
                     /locus_tag="ACL8AS_001201"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="HGS1229065.1"
                     /translation="MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIA
                     CHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGN
                     TFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEIS
                     AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAE
                     IFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDL
                     GVPLSLITESVFARYISTYKEERVHASKVLPKPAAFNFEGDKAELIEKIRQALYFSKI
                     ISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLL
                     LDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRD
                     YFGAHTYQRKDKEGTFHYSWYDEK"
     gene            16700..17389
                     /locus_tag="ACL8AS_001202"
     CDS             16700..17389
                     /locus_tag="ACL8AS_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000518023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HGS1229066.1"
                     /translation="MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQ
                     TDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMILDHWEDLQEELEVVQRFAVSYIY
                     KPVFIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
                     REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIK
                     TVRGVGYTMQE"
     gene            17487..18506
                     /gene="cbpC"
                     /locus_tag="ACL8AS_001203"
     CDS             17487..18506
                     /gene="cbpC"
                     /locus_tag="ACL8AS_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpC"
                     /protein_id="HGS1229067.1"
                     /translation="MKLLKKMMQVLLAVFFFGLLATNTVFANTTGGRFVDKDNRKYYV
                     KDDHKAIYWHKIDGKTYYFGDIGEMVVGWQYLEIPGTGYRDDLFDNRPVFEIGLQEKW
                     YYFGQDGALLEQTDKQVLEAKTSENTGKVYGEQYPLSAEKRTYYFDNNYAVKTGWIYE
                     DGNWYYLNKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDPTTGIM
                     QTGWQYLGNKWYYLRSSGAMATGWYQEGTTWYYLDQPNGDMKTGWQYLGNKWYYLRSS
                     GAMATGWYQDGSTWYYLNTSNGDMTTGWFQVNGNWYYAYSSGALAVNTTVDGYYVNYN
                     GEWVR"
     gene            complement(18624..19856)
                     /locus_tag="ACL8AS_001204"
     CDS             complement(18624..19856)
                     /locus_tag="ACL8AS_001204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HGS1229068.1"
                     /translation="MKLFWTNNIYRQLLLNSCFSSFGDSIFYLAIINYVAQYNFAPLA
                     ILLISISEMVPLLSQLFLGILGDFQENRVKHALWIAKIKILLYAILTVFLVLSPFSLV
                     SVIMIVIINLISDTLSYLSAYMMNALYISVIKDDLHDAMGFRQSLMRVVHIVANLAGA
                     FLINVMSIQTISLINTLTFVIAFLGLYVIRHTLYEVEKRIEMSHTALSFKKYFQHLKQ
                     SLAVLLRLKDTVILLFLTTSMIAILDVSPRLIALRFIQQTLAQLSIGQLLAMLSIIIS
                     CGAILGNMTSSNLFKNIRFTHLLVFCEISLLTLITSILCQAYIVIFMTSFISSTIIGI
                     LSPRLQAAVFAHIPSDKIGTVGSALSTVDILAPSLLSLLALSIASGVSVQLALIFLYL
                     ILIALIFCQWLVKFNTHN"
     gene            complement(20385..20742)
                     /locus_tag="ACL8AS_001205"
                     /pseudo
     CDS             complement(20385..20742)
                     /locus_tag="ACL8AS_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811282.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_process: GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lanthionine synthetase LanC family protein"
     gene            21405..21734
                     /locus_tag="ACL8AS_001206"
     CDS             21405..21734
                     /locus_tag="ACL8AS_001206"
                     /inference="COORDINATES: protein motif:HMM:NF024736.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HGS1229069.1"
                     /translation="MTRKAYDTDLNDQEWAKIEPYFSKHRTYKWPKRVLVNETLYVTK
                     TGCQWRMLPHDFPLYLTVWSFFRRSMTTGWFQVNGRWYYAYSSGALAVNTTVDGYSVN
                     YNGEWVQ"
     gene            21856..22734
                     /gene="mvk"
                     /locus_tag="ACL8AS_001207"
     CDS             21856..22734
                     /gene="mvk"
                     /locus_tag="ACL8AS_001207"
                     /EC_number="2.7.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004496 - mevalonate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0016126 - sterol biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="mevalonate kinase"
                     /protein_id="HGS1229070.1"
                     /translation="MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVP
                     AESPWRLYEEDTLSMAVYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRA
                     VFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
                     SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQI
                     LSQAHLHLKEIGVSSLEADSLVETALSHGALGAKMSGGGLGGCIIALVTNLTHAQELA
                     ERLEEKGAVQTWIESL"
     gene            22716..23669
                     /gene="mvaD"
                     /locus_tag="ACL8AS_001208"
     CDS             22716..23669
                     /gene="mvaD"
                     /locus_tag="ACL8AS_001208"
                     /EC_number="4.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000373478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0004163 - diphosphomevalonate
                     decarboxylase activity [Evidence IEA];
                     GO_process: GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="HGS1229071.1"
                     /translation="MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYT
                     ETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAA
                     GLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
                     YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLK
                     ENDFAKIGELTEKNALAMHATTKTARPAFSYLTDASYEAMDFVRQLREKGEACYFTMD
                     AGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC"
     gene            23656..24663
                     /locus_tag="ACL8AS_001209"
     CDS             23656..24663
                     /locus_tag="ACL8AS_001209"
                     /EC_number="2.7.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000562378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004631 - phosphomevalonate kinase
                     activity [Evidence IEA];
                     GO_process: GO:0016126 - sterol biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomevalonate kinase"
                     /protein_id="HGS1229072.1"
                     /translation="MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSY
                     RIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLEICGKMEREGKKF
                     GLGSSGSVVVLVVKALLALYNLSIDQNLLFKLTSAVLLKRGDNGSMGDLACIVAEDLV
                     LYQSFARQKVAAWLKEEKLATVLERDWGFSISQVRPTLECDFLVGWTKEVAVSSHMVQ
                     QIKQNINQNFLTSSKETVVSLVEALEQGKSEKIIEQVEVASKLLEGLSTDIYTPLLRQ
                     LKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADLGIELLYQERIGHDDK
                     S"
     gene            24647..25657
                     /gene="fni"
                     /locus_tag="ACL8AS_001210"
     CDS             24647..25657
                     /gene="fni"
                     /locus_tag="ACL8AS_001210"
                     /EC_number="5.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_process: GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="HGS1229073.1"
                     /translation="MTTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLS
                     TEFSGRKWDFPFYINAMTGGSNKGREINQKLAQVAETCGILFVTGSYSAALKNPTDDS
                     FSVKSSHPNLLLGTNIGLDKPVELGFQTVEEMNPVLLQVHVNVMQELLMPEGERKFRS
                     WQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRR
                     SGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRT
                     VLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEANDQMK
                     KA"
     gene            25735..26433
                     /gene="liaF"
                     /locus_tag="ACL8AS_001211"
     CDS             25735..26433
                     /gene="liaF"
                     /locus_tag="ACL8AS_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-active antibiotics response protein
                     LiaF"
                     /protein_id="HGS1229074.1"
                     /translation="MRKFKIFLFIEACLLTGALILMVSEHFSRFLLILFLFLLLIRYY
                     TGKEGNNLLLVAATILFFFIVMLNPFVILAIFVAVIYSLFLLYPMMNQEKEQTNLVFE
                     EVVTVKKEKNRWFGNLHHFSSYQTCQFDDINLFRFMGKDTIHLERVILTNHDNVIILR
                     KMVGTTKIIVPVDVEVSLSVNCLYGDLTFFNQPKRALRNEHYHQETKDYLKSNKSVKI
                     FLTTMIGDVEVVRG"
     gene            26430..27425
                     /locus_tag="ACL8AS_001212"
     CDS             26430..27425
                     /locus_tag="ACL8AS_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HGS1229075.1"
                     /translation="MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEK
                     FVFLLLVFSMSMTCLLALFWRGIEELSLRKMQANLKRLLAGQEVVQVVDPDLDASFKS
                     LSGKLNLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
                     QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELED
                     KSDLRVSLKQNMTKLPKKIEEHIFRILQELISNTLRHAQASCLDVYLYQTDVELQLKV
                     VDNGIGFQLGSLDDLSYGLRNIKDRVEDMAGTVQLLTAPKQGLAVDIRIPLLDKE"
     gene            27439..28071
                     /locus_tag="ACL8AS_001213"
     CDS             27439..28071
                     /locus_tag="ACL8AS_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HGS1229076.1"
                     /translation="MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALE
                     LRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIVTSYLDNEKIMPVLDAGAKGYML
                     KTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
                     ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGHEEF"
     gene            28147..28830
                     /locus_tag="ACL8AS_001214"
                     /pseudo
     CDS             28147..28830
                     /locus_tag="ACL8AS_001214"
                     /inference="COORDINATES: protein motif:HMM:NF020296.4"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            28980..29219
                     /locus_tag="ACL8AS_001215"
     CDS             28980..29219
                     /locus_tag="ACL8AS_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229077.1"
                     /translation="MKKTVYKKLGISIIASTLLASQLSTVSALSVISSTGEEYEVSET
                     LEKGPGSNDSSLSEISPTYGSYYQKQSEVLSVMMI"
     gene            29300..30121
                     /gene="cbpG"
                     /locus_tag="ACL8AS_001216"
     CDS             29300..30121
                     /gene="cbpG"
                     /locus_tag="ACL8AS_001216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001100143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpG"
                     /protein_id="HGS1229078.1"
                     /translation="MNVEGRGSANFIKDNVLITAAHNYYRHDYGKEADDIYVLPAVSP
                     SQEPFGKIKVKEVRYLKEFRNLNSKDAREYDLALLILEEPIGAKLGTLGLPTSQKNLT
                     GITVTITGYPSYNFKIHQMYTDKKQVLSDDGMFLDYQVDTLEGSSGSTVYDASHRVVG
                     VHTLGDGANQINSAVKLNERNLPFIYSVLKGYSLEGWKKINGSWYHYRQHDKQTGWQE
                     INDTWYYLDSSGKMLTDWQKVNGKWYYLNSNGAMVTGSQTIDGKVYNFASSGEWI"
     gene            30140..31162
                     /gene="cbpF"
                     /locus_tag="ACL8AS_001217"
                     /pseudo
     CDS             30140..31162
                     /gene="cbpF"
                     /locus_tag="ACL8AS_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771060.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpF"
     gene            complement(31290..31560)
                     /locus_tag="ACL8AS_001218"
                     /pseudo
     CDS             complement(31290..31560)
                     /locus_tag="ACL8AS_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT         9732 a         5654 c         7103 g         9071 t
ORIGIN      
        1 gttgttgaaa acattttaaa cgtttttact ttggcaaaga tgttctcaac cttgcttctc
       61 tccgtagata gtgcatggtt acaggcttta tcttcagctg ttagcggctt gagtttgctg
      121 gatttacgtg gagtttgtgc ttgaggatat atcttcataa gcccttgata accactgtca
      181 gccaagattt taccagcttg tccgatattt ctgcgactca ttttgaacaa cttcatatca
      241 tgactatagt tcacagtgat atccaaagaa ataattctcc cttgacttgt gacaatcgtc
      301 tgagccttca tagcgagaaa tatctattct atcttctaga atgtcttcca aacgaggaaa
      361 ctctcgtaaa caaagaggtt ttagaggctt atttaccatg gactaaagtt gtacaagaaa
      421 agtgcaaata agaaatctcc agattaggaa ctatatatga gttctctagt ctggagattt
      481 ttcaatagac ttcgttattg ggcggttaca atgatattca tattttttgc aaaaatgttg
      541 tttgaaaaat aattttcaaa aattctgaaa attctgaaaa ttctgttgac atctttctga
      601 aaagagtcta taatggagag aaagttttaa aggagaaaat gatgaaaagt tcaaaactat
      661 ttgcccttgc gggcgtgaca ttattggcgg cgactacttt agctgcatgc tctggatcag
      721 gttcaagcac taaaggtgag aagacattct catacattta tgagacagac cctgataacc
      781 tcaactattt gacaactgct aaggctgcga cagcaaatat taccagtaac gtggttgatg
      841 gtttgctaga aaatgatcgc tacgggaact ttgtgccgtc tatggctgag gattggtctg
      901 tatccaagga tggattgact tacacttata ctatccgtaa ggatgcaaaa tggtatactt
      961 ctgaaggtga agaatacgcg gcagtcaaag ctcaagactt tgtaacagga ctaaaatatg
     1021 ctgctgataa aaaatcagat gctctttacc ttgttcaaga atcaatcaaa gggttggatg
     1081 cctatgtaaa aggggaaatc aaagatttct cacaagtagg aattaaggct ctggatgaac
     1141 agacagttca gtacactttg aacaaaccag aaagcttctg gaattctaag acaaccatgg
     1201 gtgtgcttgc gccagttaat gaagagtttt tgaattcaaa aggggatgat tttgccaaag
     1261 ctacggatcc aagtagtctc ttgtataacg gtccttattt gttgaaatcc attgtgacca
     1321 aatcttctgt tgaatttgcg aaaaatccga actactggga taaggacaat gtgcatattg
     1381 acaaagttaa attgtcattc tgggatggtc aagataccag caaacctgca gaaaacttta
     1441 aagatggtag ccttacagca gctcgtctct atccaacaag tgcaagtttc gcagagcttg
     1501 agaagagtat gaaggacaat attgtctata ctcaacaaga ctctattacg tatctagttg
     1561 gtacaaatat tgaccgtcag tcctataaat acacatctaa gaccagcgac gaacaaaagg
     1621 catcgactaa aaaggctctc ttaaacaagg atttccgtca ggctattgcc tttggttttg
     1681 atcgtacagc ctatgcctct cagttgaatg gacaaactgg agcaagcaaa atcttacgta
     1741 atatctttgt tccaccaaca tttgttcaag cagatggtaa aaactttggc gatatggtca
     1801 aagagaaatt ggttacttat ggggatgaat ggaaggatgt taatcttgca gattctcagg
     1861 atggtcttta caatccagaa aaagccaagg ctgaatttgc taaagctaaa tcagccttac
     1921 aagcagaagg tgtgacattc ccaattcatt tggatatgcc agttgaccaa acagcaacta
     1981 caaaagttca gcgcgtccaa tctatgaaac aatccttgga agcaacttta ggagcggata
     2041 atgtagtcat tgatattcaa caactacaaa aagacgaagt aaacaatatt acatattttg
     2101 ctgaaaatgc tgctggcgaa gactgggatt tatcagataa tgtcggttgg ggtccagact
     2161 ttgccgatcc atcaacctac cttgatatca tcaaaccatc tgtaggagaa agtactaaaa
     2221 catatttagg gtttgactca ggggaagata atgtagctgc taaaaaagta ggtctatatg
     2281 actacgaaaa attggttact gaggctggtg atgaggctac agatgttgct aaacgctatg
     2341 ataaatacgc tgcagcccaa gcttggttga cagatagtgc tttgattatt ccaactacat
     2401 ctcgtacagg gcgtccaatt ttgtctaaga tggtaccatt tacaatacca tttgcattgt
     2461 caggaaataa aggtacaagt gaaccagtct tgtataaata cttggaactt caagacaagg
     2521 cagtcactgt agatgaatac caaaaagctc aggaaaaatg gatgaaagaa aaagaagagt
     2581 ctaataaaaa ggctcaagaa gatctcgcaa aacatgtgaa ataactgttg caaaatataa
     2641 gaaaggattt agtatttctc ttgaatgctg aatccttttt tacatttgta aagaaagatt
     2701 ctaaatgtac tgccccccaa aagttggagc ctctttttgt cagaatagag aaaatttttg
     2761 ttaattttac ttgtttccta ttgctttatc agttattatt tgttatatta aaagtataac
     2821 tattttttat ttatcagggt taagcattgc actttcagag gaaggagtat tttttaaaaa
     2881 ggaaatgtaa acgcttgccc aaaaatgaaa ggatttagaa gtttatgaat aaaggattat
     2941 ttgaaaaacg ttgtaaatat agtattcgga aattttcatt aggtgttgct tctgttatga
     3001 ttggagctgc attctttggg acaagtccgg ttcttgcaga tagcgtgcag tctggttcca
     3061 cggcgaactt accagctgat ttagctactg ctcttgcaac agcaaaagag aatgatgggc
     3121 gtgattttga agcgcctaag gtgggagaag accaaggttc tccagaagtt acagatggac
     3181 ctaagacaga agaagaacta ttagcacttg aaaaagaaaa accggctgaa gaaaaaccaa
     3241 aagaggataa acctgcagct gctaaacctg aaacacctaa gacggtaacc cctgaatggc
     3301 aaacggtaga gaaaaaagaa caacagggaa cagtcactat ccgagaagaa aaaggtgtcc
     3361 gctacaacca actatcctca actgctcaaa atgataacgc aggtaaacca gccctgtttg
     3421 aaaagaaggg cttgaccgtt gatgccaatg gaaatgcaac tgttgattta accttcaaag
     3481 atgattctga aaagggcaaa tcacgctttg gtgtcttctt gaaatttaaa gataccaaga
     3541 ataatgtttt tgtcggttat gacaaggatg gctggttctg ggaatacaaa actccaggta
     3601 atagcacatg gtataaaggc aaccgtgttg ctgctcctga aacaggatca acaaaccgtc
     3661 tctctatcac tctcaagtca gacggtcagc taaatgccag caataacgat gtcaatctct
     3721 ttgacacagt gactctacca gctgcggtca atgaccatct taaaaatgag aagaagattt
     3781 ttctcaaggc gggctcttat gacgatgagc gaacagttgt tagtgttaga acagataacc
     3841 aagagggggt aaaaacagag gatacccctg ctgaaaaaga aacaggtcct gaagttgatg
     3901 atagcaaggt gacttatgac acgattcagt ctaaggccct caaagcagtg attgaccaag
     3961 ccttccctcg tgtcaaggaa tacagcttga atggacatac tttgccagga caggtgcaac
     4021 agttcaacca agtctttatc aataaccacc gaatcacccc tgaagtcact tataagaaaa
     4081 tcaatgagac aacagcagag tacttgatga agattcgcga tgatgctcac ttaatcaatg
     4141 cggaaatgac agtacgcttg caagttgtgg acaatcaatt gcattttgat gtgaccaaga
     4201 ttgtcaacca caatcaagtc actccaggtc aaaagattga tgacgaaaga aaactacttt
     4261 cttctattag tttcctcggc aatgctttag tctctgtttc tagtgatcaa actggtgcta
     4321 agtttgatgg ggcaaccatg tcaaacaata cacatgtcag cggagatgat catatcgatg
     4381 taaccaatcc aatgaaggat ttggctaagg gttacatgta tggatttgtt tctacagata
     4441 agcttgctgc tggtgtttgg agtaactctc aaaacagcta tggtggtggt tcgaatgact
     4501 ggactcgttt gacagcttat aaagaaacag tcggaaatgc caactatgta ggaatccaca
     4561 gctctgaatg gcaatgggaa aaagcttata agggcattgt tttcccagaa tacacgaagg
     4621 aacttccaag tgctaaggtt gttatcactg aagatgccaa tgcagacaag aaagttgatt
     4681 ggcaagatgg tgccattgct tatcgtagca ttatgaacaa ccctcaaggt tgggaaaaag
     4741 ttaaggatat cacagcttac cgtatcgcga tgaactttgg ttctcaagca caaaatccat
     4801 tccttatgac cttggatggt atcaagaaaa tcaatctcca tacagatggt cttgggcaag
     4861 gtgttctcct taaaggatat ggtagcgaag gccatgactc tggtcacttg aactatgctg
     4921 atattggtaa gcgtatcggt ggtgtcgaag acttcaagac cctaattgag aaggctaaga
     4981 aatatggagc tcatctaggt atccacgtta acgcttcaga aacttatcct gagtctaaat
     5041 acttcaatga aaaaattctc cgtaagaatc cagatggaag ctatagctat ggttggaact
     5101 ggctagatca aggtatcaac attgatgctg cctatgacct agctcatggt cgtttggcac
     5161 gttgggaaga tttgaagaaa aaacttggtg acggtctcga ctttatctat gtggacgttt
     5221 ggggtaatgg tcaatcaggt gataacggtg cctgggctac ccacgttctt gctaaagaaa
     5281 ttaacaaaca aggctggcgc tttgcgatcg agtggggcca tggtggtgag tacgactcta
     5341 ccttccatca ctgggcagct gacttgacct acggtggcta caccaataaa ggtatcaaca
     5401 gtgccatcac ccgctttatc cgtaaccacc aaaaagatgc ttgggtaggg gactacagaa
     5461 gttatggtgg tgcagccaac tatccactgc taggtggcta cagcatgaaa gactttgaag
     5521 gctggcaagg aagaagtgac tacaatggct atgtaactaa cttatttgcc catgacgtca
     5581 tgaccaagta cttccaacac ttcactgtaa gtaaatggga aaatggtaca ccggtgacta
     5641 tgaccgataa cggtagcacc tataaatgga ctccagaaat gcgagtggaa ttggtagatg
     5701 ctaacaataa taaagtagtt gtaactcgta agtcaaatga tgtcaatagt ccacaatatc
     5761 gcaaacgtac agtaacgctc aacggacgtg tcatccaaga tggttcagct tacttgactc
     5821 cttggaactg ggatgcaaat ggtaagaaac tttctactga taaggaaaag atgtactact
     5881 tcaatacgca ggccggtgca acaacttgga cccttccaag tgattgggca aagagcaagg
     5941 tttaccttta caagctaact gaccaaggta agacagaaga gcaagaacta actgtaaaag
     6001 atggtaaaat taccctagat cttctagcaa atcaaccata cgttctctat cgttcgaaac
     6061 aaaccaatcc tgaaatgtca tggagtgaag gcatgcacat ctatgatcaa ggatttaata
     6121 gcggtacctt gaaacactgg accatttcag gcgatgcttc taaggcagaa attgtcaagt
     6181 ctcaaggggc aaacgatatg cttcgtattc aaggaaacaa agaaaaagtt agtctcactc
     6241 agaaattaac tggtttgaaa ccaaatacca agtatgccgt ttatgtcggt gtcgataacc
     6301 gtagtaatgc caaggcgagc atcactgtaa acactggtga aaaagaagtg actacttata
     6361 ccaataagtc tctcgctctc aactatgtta aggcctacgc ccacaataca cgtcgtgaca
     6421 atgctacagt tgacaataca agttacttcc aaaacatgta cgccttcttt acaactggat
     6481 cggacgtatc aaatgttact cttactttaa gtcgcgaagc tggtgatcaa gcaacttact
     6541 ttgatgaaat tcgtaccttt gaaaacaatt caagcatgta cggagaaaac catgatacag
     6601 gtaaaggcac cttcaaacaa gactttgaaa atgttgctca gggtatcttc ccattcgtag
     6661 tgggtggtgt cgaaggtgtt gaagacaacc gcactcactt gtctgaaaag catgatccat
     6721 atacacaacg tggttggaac ggtaagaaag ttgatgatgt tatcgatgga aattggtcac
     6781 tcaagaccaa tggactggtt agccgtcgta acttggttta ccaaaccatc ccacaaaact
     6841 tccgctttga agctggtaag acctaccgtg taacctttga atacgaagca ggttcagaca
     6901 atacctatgc ttttgtagtc ggtaagggag aattccagtc aggtcgtcgt ggcactcaag
     6961 caagcaactt agaaatgcat gaattgccaa atacttggac agattctaag aaagccaaga
     7021 aggcaacctt ccttgtgaca ggtgcagaaa caggagatac ttgggtaggt atctactcaa
     7081 ctggaaatgc aagtaatact cgtggtgatt ctggtggaaa tgccaacttc cgtggttata
     7141 acgacttcat gatggataat cttcaaatcg aagaaattac cctaacaggt aagatgttga
     7201 cagaaaatgc tctgaagaac tacttgccaa cggttgccat gactaactac accaaagagt
     7261 ctatggatgc tttgaaagag gcggtcttta acctcagtca ggccgatgat gatatcagtg
     7321 tggaagaagc gcgtgcagag attgccaaga ttgaagcctt gaagaatgct ttggttcaga
     7381 agaaaacggc tttggtagca gatgactttg aaagtttgga tgcgccagct caaccaggtg
     7441 aaggtcttga gaatgccttt gatggaaact tatctagttt atggcataca tcatggggcg
     7501 gaggagatgt aggcaagcct gcaaccatgg tcttgaaaga accaactgaa atcactggac
     7561 ttcgttatgt tccacgtgga tcaggttcaa atggtaactt gcgtgatgtg aaacttgttg
     7621 tgacagatga gtctggcaag gagcatacct ttactacaac tgattggcca gataacaata
     7681 agtcaaaaga tattgacttt ggtaagacaa tcaaggctaa gaaaattgtc cttactggta
     7741 ccaagacata cggagatggt ggagataaat accaatctgc agcggaactt atctttactc
     7801 gtccacaggt agcagaaaca cctcttgact tgtcaggcta tgaagcagct ttggctaagg
     7861 ctcagaaatt aacagacaaa gacaatcaag aggaagtagc tagcgttcag gcaagcatga
     7921 aatatgcgac ggataaccat ctcttgacgg aaagaatggt ggaatacttt gcagattatc
     7981 tcaaccaatt aaaagattct gctacgaaac cagatgctcc aactgtagag aaacctgagt
     8041 ttaaacttag ctctttagct tccgatcaag gtaagacgcc agattataag caagaaatag
     8101 atagaccaga aacacctgaa caaatcttgc cagcaacagg tgagagtcaa tctgacacag
     8161 ccctcttcct agcaggtgtt agcctagccc tatctgctct ctttgtagta aaaacgaaga
     8221 aagactagta tttagtaaaa cctcttaaca agattacgga agcagtctct atcttttcca
     8281 atgaggttta tagtacagaa aaaatctgag aagatgtctt ctcagacttt tgttaagcac
     8341 ataaatacaa tagtgctatg acaaaatcac ccagaaaatc tgggtgataa atgttatggt
     8401 tgtgctggtt gaggattctg attttgttga tcaggggttg tatttgattg ttgcgtatta
     8461 ttgttaggat tggtagtcgt actattattt gtgcttggag tggttgagct agactgtgaa
     8521 gttgaactat ctgatgatga gcttgaactt tcagttgatg ggggttgttg tggagcaggt
     8581 gagctccacg tagaacgagc accattttta aatacgaatt ctccatttct gtagagcccc
     8641 tctggtatat tccaatcctc tggattgctt ccttcagaca ggtaggtcat catagagcga
     8701 taaactttag ctgcaactag gaaaccatct ccaacgatag gagttaaacg attcgaataa
     8761 cctgtccata cagccataga atacttacga gtataaccca caaacatttc atctggagct
     8821 acgtagccag tgttcttgat atacttttca atttcttcgt cagtatagtt agaagtacct
     8881 gtcttacctg cttgtggaag ccatggtagg taggctccac gtcctgttcc gtaagttaaa
     8941 acagttttca tcatttcagt catcatatag gcagtagtct ctttcatagc tcgtgtacca
     9001 gcatcagaaa attctttttc gctaccatca ctaaagacga ttttattgat atacattggt
     9061 ttgtgataaa taccaccatt agcaaaagca gcgtaggcag cagccatttt ttcactactt
     9121 gcaccatatt ttttgttgga ttcagttgtg ttacttgaaa tggcgtttgc ataatgcatg
     9181 cttggatagt cgataccaag accattaagg aaggttttag ctctatctag accgacctta
     9241 ttcaaagtct caacggctgt gacatttcgt gattgttgaa gagcatactg gattgtaatg
     9301 tttccaaagt agacatgatc ccagttgtag agtggagtat cagtgccagg atagttataa
     9361 gggacatcat gtacaataga agcagtagag tcatagactc catattctaa agcgggagca
     9421 tagtcagtga ttggtttcat tgatgatccc cagtcacgat tggtttctac ggcctggttg
     9481 gtaccgaatg aaacattact tgcttgatga cgagcaccaa gttgtgcgat gactttacca
     9541 tttgaaacat ctacgaccgt agatgcgact tgcaaatcat cgtcagggta agagacgtat
     9601 tgatcggagt tgtagatatc ccacagatgt ttttgagctt cttggtctac atttgtgtaa
     9661 acatccatcc cagtagttag aaggttatag ccagtttctt gttctacttg gtcgataacc
     9721 tctttgagat aattgtccat atatgctgga tagctattga ccgatttcaa actttggagt
     9781 ccatcagtaa taggggtatt aatagccttc tcatactgtt cggcagaaat gtagccttga
     9841 cctttcatct ctgaaagtac caagttacga cggtcaaggg cagcttctgg atgagaatag
     9901 ggatcgtatt gattcggagc ctgtggcatt cctgctagta gggcaagttg aggtaatgat
     9961 agttctcgca aatctttgcc gtaatagttt tgggcagccg tctgcattcc atagtttccg
    10021 ttagacatgt aaactttatt cacatagtag gtcaggattt cttgttttgt ggctttttgt
    10081 tctaattgaa cagccaacca agcttcctgg gctttacgtg aaatggtctg atcagaagtg
    10141 gaagttgaga aataggtcaa cttaattaat tgttgggtaa gggtagatcc tccctggagg
    10201 gagttgtttt gtaagttacg taaaaaagct cctataattc ggatggtatc gacaccgcga
    10261 tgatcgaaaa aacgatggtc ttcgatcgat acgatagcct tgaccaaatc agtaggaatt
    10321 tcgttggcct gagcgtttac tcggcgttca gagcccagat cggcaatcag ttcgttttta
    10381 ctatcgaaaa tcttactaga cgtggttgcg actaatttgc tctcagatag ggctggggct
    10441 ttgctgacgt aatagagaaa tatgcctcct cccagcataa ctgctgtgat aaataaagtt
    10501 aagaagcaga tactcacata cttagctatt cgcaggatag tttgtttgtt catcttgttt
    10561 taccacctaa taaatgttct ttgataacat tgagataggg aatttgaggg aaggcaccag
    10621 ccttgatttc atatccatat tctcgaatat atccaagtgg cattgatttt tgccccttat
    10681 cttgatgata gaagcgaatc aaatcatatg ccggtaataa gtaggtttct tgctgagaag
    10741 aaaagtgaag aaggacaaag cagattcctt gttgagcaag gatttgttcc atatgctgaa
    10801 tctgatgtgg atggaaattt ttcatcggaa tcgcacgttt ttgttttgtt tccttggctt
    10861 caaagtcgat gtaatatcca ttataaacgc cagaatagtc cgtcgttgaa gcttgtcgaa
    10921 aataggcttc aacaatcttg gcacgacttc gttgtggata gtccacttgt acgatttgaa
    10981 taggagttgg tttcttatgt atgacagcca agccctgaga caaatagtag tcgttggtag
    11041 cattgatcat cttttcaaaa gacattcctc gatttgcgaa atttttgggt tgagaaagag
    11101 atgtttgtct tttttgtgat gaaactttat gtggatagtt gaccataatt ctccttattg
    11161 gtacaataac atcactttat tataccataa tttgcacaga aagggttaaa aatggctaca
    11221 gctttggttt taggctattc tgcttttgat ttgggtttat tttctgataa ggatcctcgt
    11281 cttaaattga ttaaaaaagc gatacgtaaa gatttagagg ctatggcagc agatggggtg
    11341 tcttggcttg tgtttacagg aagtttgggt tttgaatatt gggttttaga ggttgctcag
    11401 gagatgaaaa ccgaatacgg tttccagttg gccaccattt ttgcttttga aacccatggg
    11461 gaaaattgga atgaaggcaa tcagatgaaa ctgagtcgct ttaagcaggt agactttgtc
    11521 aaatatgctt atcctcgtta tgaacacaag gggcagttaa gagattatca gcaatttttg
    11581 ctggaaaaca cgactagttc ctatcttttt tatgatgaag aaaatgaaac aaaactagct
    11641 tatttttacc aaaagatgaa aaatcaagag gactatttta taaagagatt aacatttgat
    11701 gaattaaatg aacttgctga aaatttttcc gaaaattgaa gctttgacct tgatttttgt
    11761 ttgccttttt ttatataata atactagcaa gcgagaatgg agagagacat ggcaagtatt
    11821 attttttcag cgaaagatat ttttgaacaa gagtttggac gtgaagtccg tggctataat
    11881 aaagtagaag ttgacgagtt tttagacgat gtcatcaagg actatgaaac ctatgctgcc
    11941 ttggtcaagt cacttcgtca ggaaattgcg gatttgaagg aagaattaac tcgtaaaccg
    12001 aaaccttcac cagttcaagc agaacccctt gaagcggcaa ttacaagttc tatgacgaat
    12061 tttgatattt tgaaacgcct gaatagattg gaaaaagaag tttttggtaa acaaatttta
    12121 gataactcag atttttaagt agttatttga gatgtgcaat ttttggataa tcgcgtgagg
    12181 agaattgctt ctcatgagga aagtccatgc tagcacaggc tgtgatgcct gtagtgtttg
    12241 tgctaggcga aaccataagc ctagggacga gaaatcgtta cggcagttga aatggctaag
    12301 tccttggata ggccagagta ggcttgaaag tgccacagtg acggagtctt tctggaaaca
    12361 gagagagtgg aacgcggtaa acccctcaag ctagcaaccc aaattttggt cggggcatgg
    12421 agtacgcgga aacgaacgta gtattctgac tgctatcagc tagagctgtt agtggtagac
    12481 agatgattat cgaaggaagt ggtcctagtc acttctggaa caaaacatgg cttatagaaa
    12541 attgcatata ggttggggct gagaaatttt ctcaacctca ttttttaaag tggacatata
    12601 gaaaggtctt gcaagactgt aacatgaaaa aaaaatttaa tttaattgca actgtggcag
    12661 cagggcttga ggctgtcgtt ggtcgtgaag tgcgagagtt gggctacgat tgtcaggttg
    12721 aaaatggacg tgttcgtttt caaggagacg tgagagctat tatcgaaacc aacctttggc
    12781 ttcgggcagc agatcgtatc aaaattatcg taggaacgtt cccagctaag acttttgaag
    12841 agctatttca gggagttttc gctttggatt gggaaaatta tttaccactt ggagctcggt
    12901 tcccgatttc aaaagctaaa tgtgttaagt ccaaacttca caatgagccc agtgttcagg
    12961 ctatttctaa gaaagctgtt gtcaagaaat tgcagaaaca ctatgctcgc ccagaagggg
    13021 ttcctctgat ggagaatggc ccagagttta agattgaggt ctctattctc aaagatgtgg
    13081 caactgtcat gattgatacg accgggtcta gcctctttaa acgtggttat cgtaccgaaa
    13141 aaggtggtgc tcctatcaag gaaaatatgg cagcagccat tttacaactt tctaactggt
    13201 atccagacaa gcctttgatt gatccgacct gtggttcggg gactttctgt attgaggcag
    13261 ttatgattgc tagaaagatg gcgccaggtc ttcgtcgctc ttttgcattt gaggaatgga
    13321 actggatcag cgatcgcttg attcaagaag tgcgcacaga agcggctaaa aaagtagacc
    13381 gtgagcttga gctggatatc atgggttgtg atattgatgc tcgcatggtg gaaattgcta
    13441 aggccaatgc tcaggcagct ggtgttgcag gagacattac ttttaagcag atgcgcgtgc
    13501 aggatttacg ttccgataaa atcaatggag taatcatttc caatccgcct tatggtgaac
    13561 gtttgtcaga tgatgcaggg gtgaccaagc tctatgctga gatggggcaa gtatttgcac
    13621 cgctgaaaac ttggagcaaa tttatcctga ctagtgatga agcctttgaa agcaagtatg
    13681 gtagccaagc agataagaag cgtaagttat acaacggaac cttgaaagtg gatctgtatc
    13741 aatattttgg tcagcgtgtc aaacggcaag aggtaaaata gaaagggata ctcatgagta
    13801 aaaaaagacg aaatcgtcat aaaaaagaag gtcaagaacc gcaatttgat tttgatgaag
    13861 caaaagagct aacagttggt caagcgattc gtaaaaatga agaagtggaa gcaggagtct
    13921 tgtctgagga ttccattttg gacaagtatg tcaagcaaca cagagatgaa attgaggcgg
    13981 ataagtttgc gactcgtcaa tacaaaaaag aggagttagt cgaaactcag agtctggatg
    14041 atttaattca agagatgcgt gaggctgtag aagagtcaga agcttattcg gaggaagttc
    14101 catcttctga agacatctta ccacccttgc ctctggatga tgaggagcaa ggcttggatc
    14161 ctctattact agaggatgaa aatccaacag aaatgactga agaagtggaa gaggagcaaa
    14221 atctttctcg tctggaacaa gaagagtcag aaaagaaaag caaaaaaggc tttgttttaa
    14281 ccgctttggc gcttgtatca gtgattatct gtgtcagtgc ttattatgtc tatcgtcaag
    14341 tgaatcgctc gaccaaggaa attgaaactt ctcaatcaac tacagccaat caatcggatg
    14401 tggatgattt taatacactt tatgacgcct tctacacaga cagtaataaa acggctttga
    14461 aaaatagcca gtttgataaa ctaagtcaac tcaagacctt acttgataag ctggaaggta
    14521 gtcgtgaaca tacgcttgcc aaatctaaat atgatagtct agcaacgcaa atcaaggcca
    14581 ttcaagatgt caatgcacaa tttgaaaaac cagctattgt ggatggtgtg ttggatacca
    14641 atgccaaagc caaatcggat gctaaattta cagatattaa aactggaaat acggagcttg
    14701 ataaagtgct agataaggct atcagccttg gtaagagcca gcaaacaagt acttctagct
    14761 caagttcaag tgaaactagt agctcaagca ctagtcaaac aagctcaaat acgactagtg
    14821 agacaagccc aagtagttca aatgagacta gaagtagtcg cagtgaagtc aatatgggtc
    14881 tctcgagtgc aggggttgct gttcaaagaa gtgccagtcg tgttgcctat aatcagtctg
    14941 ctattgatga tagtaacaac tctgcctggg attttgcgga tggtgtcttg gaacaaattc
    15001 tagctacttc acgttcacgt ggctatatca ctggagacca atatatcctt gaacgtgtca
    15061 atatcgttaa tggcaatggt tattacaacc tctacaagcc agatggaacc tatctcttta
    15121 cccttaactg taagacaggc tactttgtcg gaaatggcgc tggtcacgcg gatgacttgg
    15181 actactaagc agtcgttaca aaattctttc ttttcaaaag taaaaatgat aaaataaaac
    15241 aaatgaaaca agaggagtgt caaatgacaa aagctaactt tggtgtcgta ggtatggccg
    15301 taatgggtcg taaccttgcc cttaatattg aatctcgtgg ttacacagtt gctatttaca
    15361 accgtagtaa agaaaaaact gaagatgtaa ttgcttgcca tcctgaaaag aactttgtac
    15421 caagctatga cgttgaaagt tttgtaaact caatcgaaaa acctcgtcgt atcatgctga
    15481 tggttcaagc tggacctggt acagatgcta ctatccaagc ccttcttccg caccttgaca
    15541 agggtgatat cttgattgac ggaggaaaca ctttctacaa agataccatc cgtcgtaatg
    15601 aagaattggc aaactcaggt atcaacttta tcggtactgg agtttctggt ggtgaaaaag
    15661 gtgcccttga aggtccttct atcatgcctg gtggacaaaa agaggcctac gaattggttg
    15721 cggatgttct tgaagaaatc tcagctaaag caccagaaga tggcaaacca tgtgtgactt
    15781 atatcggtcc tgatggagct ggtcactatg tgaaaatggt tcacaacggt atcgagtacg
    15841 gtgatatgca attgatcgca gaaagctatg acttgatgca acacttgcta ggcctttctg
    15901 cagaggatat ggctgaaatc tttactgagt ggaacaaggg tgaattggat agctacttga
    15961 tcgaaatcac agctgatatc ttgagccgta aagacgatga aggccaagat ggaccaatcg
    16021 tagactacat ccttgatgct gcaggtaaca agggaactgg taaatggacg agccaatcat
    16081 ctcttgacct tggtgtacca ttgtcactga ttactgagtc agtgtttgca cgctacattt
    16141 caacttacaa agaagaacgt gtacatgcta gcaaggtgct tccaaaacca gctgccttca
    16201 actttgaagg agacaaggct gaattgattg aaaaaatccg tcaagccctt tacttctcaa
    16261 aaatcatttc atacgcacaa ggatttgctc aattgcgtgt agcctctaaa gaaaacaact
    16321 ggaacttgcc atttgcagat atcgcatcta tctggcgtga tggctgtatc atccgttctc
    16381 gtttcttgca aaagattaca gatgcttaca accgtgatgc agaccttgcc aaccttcttt
    16441 tggatgaata cttcttggat gttactgcta agtatcaaca agcagtgcgt gatatcgtag
    16501 ctcttgcggt tcaagctggt gtgccagtgc caactttctc agcagctatt acttactttg
    16561 atagctaccg ttcagctgac cttccagcta acttgatcca agcacaacgt gactactttg
    16621 gtgcccacac ttaccaacgt aaagacaaag aaggaacctt ccactactct tggtatgacg
    16681 aaaaataagt aggtcagcca tggggaaacg gattttatta cttgaaaaag aacgaaatct
    16741 agctcatttt ttaagtttgg aactccagaa agagcagtat cgggttgatc tggtagagga
    16801 ggggcaaaaa gccctttcca tggctcttca gacagactat gatttgattt tattgaacgt
    16861 taatctggga gatatgatgg ctcaggattt tgcagaaaaa ttgagtcgaa ctaaacctgc
    16921 ctcagtcatc atgattttag atcattggga agacttgcaa gaagagctgg aagttgttca
    16981 gcgttttgca gtttcataca tctataagcc agtctttatc gaaaatctgg tagcgcgtat
    17041 ttcggcgatc ttccgaggtc gggacttcat tgatcaacac tgcagtctga tgaaagttcc
    17101 aaggacctac cgcaatctta ggatagatgt tgaacatcac acggtttatc gtggtgaaga
    17161 gatgattgct ctgacccgcc gtgagtatga ccttttggcg acacttatgg gaagcaagaa
    17221 agtattgact cgtgagcaac tgttggaaag tgtttggaag tatgaaagtg cgaccgagac
    17281 aaatatcgta gatgtctata tccgctatct acggagcaag cttgatgtta aaggtcaaaa
    17341 aagctacatt aaaaccgtgc gtggtgttgg ttacaccatg caagaataga aaagcagttg
    17401 cagttgtgta actgcttttt tgaggagttt ttatatattg acatgcagtc gggtctttgc
    17461 tacaatcgtt ttaggaggat atatagatga aacttttgaa aaaaatgatg caagttctac
    17521 tagcagtctt tttctttggt ttgctagcta caaatacggt atttgcgaat accacaggtg
    17581 gccgatttgt tgataaggat aatagaaaat attatgtaaa agatgatcat aaagcaatct
    17641 attggcataa aatagacggt aaaacttact attttggtga tattggagag atggttgtcg
    17701 gttggcaata cttagaaatt cctggaacag gttatcgtga tgatttattt gataatcgtc
    17761 cagtcttcga aattggcctt caggagaagt ggtactattt tggacaagat ggtgctttgc
    17821 tagaacaaac agataaacaa gtactagagg caaaaacgtc tgaaaataca ggaaaagtat
    17881 acggtgaaca atatcctcta tctgctgaaa agagaactta ttattttgat aataattatg
    17941 ctgtaaagac aggctggatt tatgaagacg gcaattggta ttatttaaat aagctaggaa
    18001 attttggtga tgattcttac aatccactac caattggtga agttgctaag ggttggactc
    18061 aagattttca tgttactatt gacattgata gaagcaaacc tgctccatgg tactacctag
    18121 atccaacaac tggtattatg caaacaggtt ggcaatatct aggtaataag tggtactacc
    18181 tccgttcctc aggagcaatg gccactggct ggtatcagga aggtaccact tggtattatt
    18241 tagaccagcc aaatggcgat atgaaaacag gctggcaata ccttggtaac aagtggtact
    18301 atctccgttc atcaggagct atggcaactg gctggtatca agatggttca acttggtact
    18361 acctaaatac aagtaatgga gatatgacga caggttggtt ccaggtcaat ggcaactggt
    18421 actatgctta tagctcaggt gctttggcgg tgaatacgac cgtagatggc tactacgtca
    18481 actataatgg cgaatgggtt cggtaatgac agggcgctta taattatatt agaacactcg
    18541 cttaatcaaa gaagtgactt tgttgtactt gacctgacga ttggggagat taaaagcatg
    18601 tgaaatctac acatgctttt tcgttagtta tgagtgttga acttgactaa ccattgacaa
    18661 aagataagag caatcaaaat aagatacaaa aatatcaatg ctaactgcac cgaaacgccc
    18721 gatgctatgg acagggctaa tagggagagc agggacgggg cgagaatgtc tactgtgctc
    18781 agagcagagc ccaccgtccc aatcttgtca ctggggatat gggcaaagac agctgcttgt
    18841 aggcgagggc tgagaatgcc gataatcgta gaactgatga aactggtcat gaaaattacg
    18901 atataggctt gacaaaggat actagttatt agagtcaata gggaaatctc acagaaaacc
    18961 aagaggtgcg tgaaacggat atttttaaat agattactgc tggtcatatt gccaaggata
    19021 gctccacaag aaatgatgat ggagagcatg gcgaggagtt gcccaatgct cagttgtgct
    19081 agtgtctgtt ggatgaagcg gagggcaatc agccgagggg acacatccaa gatggcaatc
    19141 atactggtcg tcagaaacag tagtatgacg gtatctttta acctcaggag cacagccagc
    19201 gactgtttaa gatgttgaaa atatttctta aaactcagtg ctgtatgtga catttcaatc
    19261 cttttttcaa cctcatacaa ggtatgtcta ataacataca gacccaaaaa ggcaatgaca
    19321 aaagtcagag tgttgataag ggaaatagtt tgaatactca taacattgat aaggaatgcg
    19381 ccagccagat tggcgacaat gtggacaacc ctcatcagag actgcctgaa ccccatggca
    19441 tcatgcaggt cgtccttaat tacactgatg tagagggcgt tcatcatgta ggcagacagg
    19501 tagctcaagg tgtcagagat gaggttgatg atgacaatca taatgactga aactaatgaa
    19561 aagggcgaca agacgagaaa tactgtcaaa atagcgtaga gcaggatttt gattttggca
    19621 atccagagtg cgtgtttgac tctattttct tgaaaatctc ctagaatccc gagaaagagt
    19681 tgcgatagta ggggaaccat ctctgaaatg gaaatcagta aaatcgctag cggagcgaaa
    19741 ttgtactgag ccacataatt gataatggcg aggtagaaaa tactgtcgcc gaatgatgaa
    19801 aaacagctgt ttagcagcaa ctgtctatat atgttgtttg tccaaaataa tttcatactt
    19861 ttctccttat gtctgcacat cgaatgggaa tttattattt aatagacacc aatatacccc
    19921 atgcttccta ttccgaagtc aaacaaatct gttttaccac tatctccttg aaacatcagt
    19981 aaaccgtgat catctcgttc agaacatgct aaaattacct gttggatttt ttcatcagta
    20041 atttgttttg attgtagaca gtggtttgta gtaagctagt tattccgtgg caatatcctg
    20101 tcatcatttt tagatgatgg ttaaaaacaa attcttgata tttactaata atatctttgt
    20161 ttccgtcaca atcgtacata caaagatata agattattcc ggaaattcct tcgcaccaag
    20221 aaagttgtaa atttcctaaa ttttcagtat tagaagtaac tttttctaat aattttttta
    20281 attcagtatg gaatgtatgg agatcattat agaacataga aggttctaag actttagaat
    20341 aggcaaataa agcctatgca attccacaat atccatgagc aaagctatag tctaaaatgc
    20401 tttctttggc tatatctctt tgtaggaaat aatgctaaat ttcccctata ctattgtgga
    20461 tgaaagtttt aagagtattg tcattggtaa attgatagta ttttattaat gataatagga
    20521 caccagattt tcccaatgca aagtctattt cctctagagt atcataattc tctattaatt
    20581 tcttagcggt gacgtttgct aattgtagat agtattgatt tttactgata gaaaataaat
    20641 gtaggagtaa ccatagatag cctgcatcac caaaagatag cctgcatcac caaatagcag
    20701 tgagtattga tattcatatg tgtgtgtcgt tctaattgtc actgccttct tgatgataga
    20761 gagtatttta gaatccagtt ctggggggta caatttattt agaggaaaca gtagtccagc
    20821 tattccgtgt tggaatgata aattacttac gaaatttcca aattctgttg aagaagtgat
    20881 ccttccttca gaatttacag ttttatctag taaaaatcgt agaacactat tacattctgt
    20941 tttgtaatca tatttatgtt cctctatttt tttaattttg actaaattat ttgtttgact
    21001 taaatttagt agacattgta accaaaatag ttgctcatct gtgagctgac cttgagtatg
    21061 tgatagttct agtaattgaa taggatcctt tagttagatt caatcaatct ataacacaac
    21121 aacataataa cacttttagg ataacttatc aaatattata gtaaaatgaa ataataacag
    21181 gacaaatcga tcaggacagt caaatcgatt tctaaaaatg ttttagaagt agaggtgtac
    21241 tattctagtt tcaatctact atagtatata tttttacatc ttgaattgtc aaattaagtg
    21301 cataactttc ccgtagcata cttcataagg cgttttccac ttaagaaatt ttcgtggtcg
    21361 attatttaga acctctattc acaaaaaaat gttaaactag agttatgaca cgcaaagcat
    21421 atgatactga tttaaatgat caagaatggg ctaagattga accctatttc tccaaacacc
    21481 gcacctataa atggccgaaa cgagtacttg ttaatgagac tttgtacgtc actaaaacag
    21541 gttgtcaatg gcgcatgctc cctcacgact ttcctcttta cttaacggta tggagtttct
    21601 ttcgtcgttc tatgacgaca ggttggttcc aggtcaatgg cagatggtac tacgcttata
    21661 gctcaggtgc cttggcagtg aatacgactg tagatggcta ttctgtcaac tataatggcg
    21721 aatgggttca ataatgaaag aagcgattgt gaatggaaac aatcgctttt tttgtgaaaa
    21781 tataataaaa tagataggaa agaattaata cttgtatgaa aaataagacg ttttttcgtc
    21841 tagtaaaagg aaaaaatgac aaaaaaagtt ggtgtcggtc aggcacatag taagataatt
    21901 ttgatagggg aacatgcggt cgtttacggt tatcctgcca tttccctgcc tcttttggag
    21961 gtggaggtga cctgtaaggt agttcctgca gagagtcctt ggcgccttta tgaggaggat
    22021 accttgtcca tggcggttta tgcctcactg gagtatttga atatcacaga agcctgcatt
    22081 cgttgtgaga ttgactcggc tatccctgag aaacggggga tgggttcgtc agcggctatc
    22141 agcatagcgg ccattcgtgc ggtatttgac tactatcagg ctgatctgcc tcatgatgta
    22201 ctagaaatct tggtcaatcg agctgaaatg attgcccata tgaatcctag tggtttggat
    22261 gctaagacct gtctcagtga ccaacctatt cgctttatca agaacgtagg atttacagaa
    22321 cttgagatgg atttatccgc ctatttggtg attgccgata cgggtgttta tggtcatact
    22381 cgtgaagcca tccaagtggt tcaaaataag ggcaaggatg ccctaccgtt tttgcatgcc
    22441 ttgggagaat taacccagca ggcagaagtt gcgatttcac aaaaagatgc tgaagggctg
    22501 ggacaaatcc tcagtcaagc acatttacat ttaaaagaaa ttggtgtcag tagccttgag
    22561 gcagactctt tggttgaaac agctcttagt catggtgctc tgggtgccaa gatgagcggt
    22621 ggtgggctag gaggttgtat catagccttg gtaaccaatt tgacacacgc acaagaacta
    22681 gcagaaagat tagaagagaa aggagctgtt cagacatgga tagagagcct gtgacagtac
    22741 gttcctacgc aaatattgct attatcaaat attggggaaa gaaaaaagaa aaagagatgg
    22801 tgcctgctac tagcagtatt tctctaactt tggaaaatat gtatacagag acgaccttgt
    22861 cgcctttacc agccaatgta acagctgacg aattttacat caatggtcag ctacaaaatg
    22921 aggtcgagca tgccaagatg agtaagatta ttgaccgtta tcgtccagct ggtgagggct
    22981 ttgtccgtat cgatactcaa aacaatatgc ctacggcagc gggcctgtcc tcaagttcta
    23041 gtggtttgtc cgccctggtc aaggcttgta atgcttattt caagcttgga ttggatagaa
    23101 gtcagttagc gcaggaagcc aagtttgcct caggttcttc ttctcggagt ttttatggac
    23161 cactaggagc ctgggataag gatagtggag aaatttaccc tgtagagaca gacttgaaac
    23221 tagctatgat tatgttggtg ctagaggaca agaaaaaacc aatctctagc cgtgacggga
    23281 tgaaactttg tgtggaaacc tcgacgactt ttgacgactg ggttcgtcag tctgagaagg
    23341 actatcagga tatgctgatt tatctcaagg aaaatgattt tgccaagatt ggagaattaa
    23401 cggagaaaaa tgccctggct atgcatgcta cgacaaagac tgctaggcca gccttttctt
    23461 atctgacgga tgcctcttat gaggctatgg actttgttcg ccagcttcgt gagaaaggag
    23521 aggcctgcta ctttaccatg gatgctggtc ccaatgttaa ggtcttctgt caggagaaag
    23581 acttggagca tttgtcagaa attttcggtc agcgttatcg cttgattgtg tcaaaaacaa
    23641 aggatttgag tcaagatgat tgctgttaaa acttgcggaa aactctattg ggcaggtgaa
    23701 tatgctattt tagagccagg gcagttagct ttgataaagg atattcccat ctatatgagg
    23761 gctgagattg ctttttctga cagctaccgt atctattcag atatgtttga tttcgcagtg
    23821 gacttaaggc ccaatcctga ctatagcttg attcaagaaa cgattgcttt gatgggagac
    23881 ttcctcgctg ttcgcggtca gaatttaaga cctttttccc tagaaatctg tggcaaaatg
    23941 gaacgagaag ggaaaaagtt tggtctaggt tctagtggca gcgtcgttgt cttggttgtc
    24001 aaggctttac tggctctcta taatctttcg attgatcaga atctcttgtt caagctgact
    24061 agcgctgtct tgcttaagcg aggagacaat ggttccatgg gcgaccttgc ctgtattgtg
    24121 gcagaggatt tggttctcta ccagtcattt gctcgccaga aggtggctgc ttggttgaaa
    24181 gaagaaaaat tggcgactgt tttagagcgt gattggggct tttcaatttc acaagtgaga
    24241 ccaactttag aatgtgattt cttagtggga tggaccaagg aagtggctgt atcgagtcac
    24301 atggtccagc aaatcaagca aaatatcaat caaaattttt taacttcctc aaaagaaacg
    24361 gtggtttctt tggtcgaagc cttggaacag gggaaatcag aaaagattat cgagcaagta
    24421 gaagtagcca gcaagctttt agaaggcttg agtacagata tttacacgcc tttgcttaga
    24481 cagttgaaag aagccagtca agatttgcag gccgttgcca agagtagtgg tgctggtggt
    24541 ggtgactgtg gcatcgccct gagttttgat gcgcaatcaa ccaaaacctt aaaaaatcgt
    24601 tgggccgatc tggggattga gctcttatat caagaaagga taggacatga cgacaaatcg
    24661 taaggacgag catatcctct atgcccttga gcagaaaagt tcctataata gctttgatga
    24721 ggtggagctg attcattctt ccttgcctct ttacaatctg gatgaaatcg atctttcgac
    24781 agagttttct ggtcgaaagt gggactttcc tttttatatc aatgccatga ctggtggaag
    24841 taataaggga agagaaatca atcaaaagct ggctcaggtg gcggaaacct gtggtatttt
    24901 atttgtaacg ggttcttata gcgcagccct caaaaatcca acggatgatt ctttttctgt
    24961 caagtctagt catcccaatc tcctccttgg aaccaatatt ggattggaca agcctgtcga
    25021 gttaggattt cagactgtag aagagatgaa tcctgttcta ttgcaagtgc atgtcaatgt
    25081 catgcaggaa ttactcatgc ccgagggaga aaggaagttt agaagctggc aatcgcatct
    25141 agcagattat agcaagcaaa ttcccgttcc tattgtcctc aaggaagtgg gctttggaat
    25201 ggatgccaag acaatcgaaa gagcctatga attcggtgtt cgtacagtgg acctatcggg
    25261 tcgtggtggc accagctttg cctatatcga aaaccgtcgt agtggccagc gtgattacct
    25321 caatcaatgg ggtcagtcta ccatgcaggc ccttctcaat gcccaagaat ggaaagataa
    25381 ggtcgaactc ttggttagtg gaggggttcg gaatccgctg gatatgatta agtgcttggt
    25441 ttttggtgct aaggctgtgg gattgtcacg aaccgttctg gaattggttg aaacctacac
    25501 agttgaagaa gtgattggca ttgtccaagg ctggaaagca gatctacgct tgattatgtg
    25561 ttcccttaac tgtgccacca tagcagatct acaaaaagta gactatcttc tttatggaaa
    25621 attaaaagaa gcaaatgatc agatgaaaaa ggcgtaacca gcgccttttt ttccatcctc
    25681 agactgaggt gacttttttg aattgtgata aaatagaagg gagaggatga acctatgaga
    25741 aaatttaaaa tctttttatt tatcgaagcc tgtcttctga caggagctct gattttgatg
    25801 gtatcagagc atttttcgcg ttttctgctg atactattcc tctttttgct tttgattcgc
    25861 tactacactg gtaaagaggg aaataatctt cttttagtag cggcaaccat tctcttcttt
    25921 ttcatcgtta tgctcaatcc ttttgtgatt ctagctattt ttgttgcggt tatctatagc
    25981 ctctttcttc tttacccgat gatgaaccag gaaaaagagc agaccaattt ggtttttgaa
    26041 gaggtcgtga cggttaagaa ggagaaaaat cgttggtttg gaaatcttca tcatttttca
    26101 agctaccaga cttgccaatt tgatgatatc aatctctttc gcttcatggg caaggacact
    26161 attcatctgg agagggtcat cttaaccaat catgacaatg tcattatcct cagaaagatg
    26221 gtaggaacga ccaaaatcat cgtacctgta gatgtggaag tcagtctcag cgttaactgt
    26281 ctctatgggg atttgacttt tttcaaccag cccaagcgag ccctccgcaa tgaacactat
    26341 catcaagaaa caaaagacta tctcaagagt aacaagagtg tcaagatttt cttgaccact
    26401 atgattggtg atgtggaggt ggttagagga tgaaaaaaca agcctatgtc attattgctc
    26461 tcacctcctt cctatttgtc ttttttttct cccacagctt gctggaaata cttgattttg
    26521 actggtctat ctttttgcac gatgtcgaaa aaacagaaaa atttgtcttt ttattgttgg
    26581 ttttcagcat gtccatgacc tgtctcttag ccctgttttg gcgagggatc gaagagcttt
    26641 ctctaagaaa aatgcaggct aatctcaagc gtttattggc agggcaagaa gtagttcagg
    26701 ttgtagatcc agatttggat gccagtttca agtccttatc aggtaaactt aaccttttga
    26761 cagaggctct tcaaaaagct gaaaatcata gccttgctca ggaagaggaa atcatcgaga
    26821 aggaacggaa gcgaattgct cgggatttgc acgatacagt cagtcaggag ttgtttgcgg
    26881 cccacatgat tttatcgggt atcagtcagc aggctttgaa attggataga gaaaagatgc
    26941 agacccagtt gcagagtgtc acagctattt tagaaacagc ccagaaggat ttgcgggttt
    27001 tgctcttgca tttgcgacca gttgaactgg agcagaagag cttgatagaa gggattcaaa
    27061 ttctcttaaa agagcttgag gacaagagtg atcttagggt tagtctcaag cagaatatga
    27121 cgaaattgcc taagaaaatc gaggagcata tcttccgtat cctgcaagag ttgattagca
    27181 atacgctccg ccatgcccag gcatcttgcc tagatgtcta cctctatcag acagatgttg
    27241 aattgcaact gaaggtggtg gacaatggga ttggtttcca gttagggagc ttagacgact
    27301 tgagttatgg actgcgaaat atcaaggatc gggttgaaga tatggcaggg acggttcagt
    27361 tattaacagc tcccaagcaa gggctggcag ttgatatccg tattcccctg ttagataagg
    27421 aatgataaag gagtaaagat gaaaatttta ctagtagatg accatgaaat ggtccgtttg
    27481 ggtttgaaaa gctactttga cctccaagac gatgtagaag ttgtgggtga ggcgtccaac
    27541 gggtctcaag ggattgactt ggccttggaa ctgcgtccag atgtcattgt catggatatt
    27601 gtcatgcctg agatgaatgg gattgacgcg accttagcaa tccttaaaga atggcctgaa
    27661 gccaagattt tgattgtgac ctcttatttg gacaatgaaa aaatcatgcc agtcttagat
    27721 gctggtgcca aaggctatat gctcaagact tctagtgcag atgaattgct tcatgccgtc
    27781 agtaaggtag ctgctggcga gctggccatt gagcaagagg ttagcaagaa ggttgaatac
    27841 caccgcaatc atatggaact tcatgaagaa ttgactgcgc gtgagcgaga tgttctccaa
    27901 ctcatcgcca agggctacga aaatcagcgc atcgcagatg acctctttat ctctctcaag
    27961 acggtcaaga cccacgtgtc caacattctt gccaaacttg aagttagcga tcgtacccag
    28021 gcggctgtct atgcctttca gcaccatttg gtcgggcatg aggagtttta gatgagttta
    28081 gcagatttac ttgaggagct agaagcagca aaagactcta aaaaagcaag gcccatggaa
    28141 gcctatatgt gccatcaatt ttcttttcta ggttgaaaga aataaactct ataaaaatat
    28201 tttccagaag cgaaaaaaac aaagattatc gattgggatt ttgcagacac ttgctgggaa
    28261 aaggagccta gaaaatacca atatgtggct gctaactatt tgaaagcaat gcagtcttat
    28321 ctaaaggaaa ccgatttgcc taagctagag cagttagtcg tgacaaaatc ctggtgggac
    28381 acggtagata tcctagatcg agtagtaggg agtttggtgt atgaacaccc tgagctagaa
    28441 gaaataatct taatactctt cgaaaatctc ttcaaaccac gtcagctcta tctgcaacct
    28501 taaaacagtg ttttgagcaa tctgcggcta gcttcctagt ttgctctttg attttcattg
    28561 agtataaaat ggagcctatc agataatatc tggctgagac gtgtcgctat taaccaccag
    28621 ttgttaagaa aagagaagac caatactcaa ttaatggaaa agattctcct tcataacttg
    28681 aaccaaacag aattttttat caataaagcc attggctgga ctctgcgaga ctactccaaa
    28741 acgaatccca cttgggtaac atgctttatt gagaaaaata aggaaagaat ggctgaactt
    28801 agtatcaaag aagcaagcaa gtacctctag cgtgattgaa aagcgcagtc attaattgaa
    28861 aagtttacct gtttatgtga taatggaggg tatttaaaga aggtggtaga tttcttgatt
    28921 ctatagtaga ttaagaaatt tagaatagta cgctataatt acattaggag gctacaataa
    28981 tgaagaaaac tgtttataaa aaattgggta tttcaattat tgcgagtact ttattggcta
    29041 gccagttatc gacagtatct gctttgagtg ttatttctag tacgggtgaa gaatatgagg
    29101 taagtgagac actagaaaaa ggtccaggat ctaatgattc ttcattatct gagatttcac
    29161 caacatatgg ttcatactac caaaagcaat cagaagtatt atcggtaatg atgatttgat
    29221 taaaattgat aatactttac agtatccgta ttcgacttca gctatggttt tatctaagta
    29281 ttatggagta gccgatggaa tgaatgtaga agggagggga agtgcgaatt ttattaaaga
    29341 taatgtgtta attacagcgg ctcacaacta ctacagacat gactatggga aagaagcgga
    29401 tgatatttat gttcttccgg ctgttagtcc aagtcaagaa ccatttggaa agatcaaagt
    29461 aaaggaagtt cgttatttga aggaatttag aaatttaaat tctaaggatg caagggaata
    29521 tgacttggct ttattaattc tagaagagcc cattggtgca aaattaggga ctttgggtct
    29581 tcctactagt caaaaaaatt tgacaggaat aactgtgact atcacaggct atccatcata
    29641 taattttaaa attcatcaaa tgtatacaga taaaaaacaa gttttaagtg atgatggcat
    29701 gttcttggat taccaagttg atactttaga ggggtctagt ggatctacag tttatgatgc
    29761 tagtcaccgt gtagtaggag tgcatacttt aggagatgga gctaatcaaa ttaacagtgc
    29821 agttaaatta aatgaacgaa atttgccatt tatttattcg gttcttaaag gttactctct
    29881 tgaaggatgg aagaaaataa atggtagttg gtaccattat agacaacatg ataaacaaac
    29941 gggttggcag gagataaatg atacttggta ttatttagac agttccggta agatgcttac
    30001 agattggcaa aaagtaaatg gaaaatggta ttatctcaat tcaaatggag caatggttac
    30061 aggtagccaa actatcgatg gtaaagttta taacttcgct tcatctggtg agtggattta
    30121 atgttggagg atatataaaa tgaagctttt gaaaaaaatg atgcaagtcg cactagccac
    30181 atttttcttc ggtttgctag ggaccagtac agtatttgca gatgattctg aaggatggca
    30241 gtttgtccaa gaaaatggta gaacctacta caaaaagggg gatctaaaag aaacctactg
    30301 gagagtgata gatgggaagt actattattt tgatccttta tccggagaga tggttgtcgg
    30361 ctggcaatat atacctgctc cacacaaggg ggttacgatt ggtccttctc caagaataga
    30421 gatttctctt agaccagatt ggttttattt tggtcaagat ggtgtattac aagaatttgt
    30481 tggcaagcaa gttttagaag caaaaactgc tacgaatacc aacaaacatc atggggaaga
    30541 atatgatagc ccagcagaga aatgagtcta ttattttgaa gatcagcgta gttatcatac
    30601 tttaaaaact ggttggattt acgaagaggg tcattggtat tatttacaga aggatggtgg
    30661 ctttgattcg cgcatcaaca gattggcggt tggagagcta gcacgtggtt gggttaagga
    30721 ttcccctctt acctatgatg aagagaagct aaaagcagct ccatggtact atctagatcc
    30781 aacaactggc attatgcaaa ctggttggca atttctaggt aatagatggt actacctcca
    30841 ttcgtcagga gctatggcaa ctggctggta taaggaaggc tcaacttggt actatctaga
    30901 tgctgaaaat ggtgatatga gaactggctg gcaatacctt ggtaacaagt ggtactatct
    30961 ccgttcatca ggagctatgg caactggttg gtatcaggaa ggttcgactt ggtactatct
    31021 aaatgcaagt aatggagata tgaaaacagg ctggttccaa gtcaatggta actggtacta
    31081 tgcctatgat tcaggtgctt tagctgttaa taccacagta ggtggttact acttaaacta
    31141 taatggtgaa tgggttaagt aatgaaggct aattgtaaac tgtgatggat acttaacttt
    31201 gtataatagg tggataaaag tcttcacaat caaaaaacgc atagtatcaa ggtttttctg
    31261 tactgccccc caaaagttag acaaataatt tatccaaagg atttagttct gtactgcaca
    31321 ggactaagtc cttttagttt taccttaatt ctcttgttgt tgtaataatc aatatagtct
    31381 ataatagctt gttccaattg attaagtgat ttaaatgttt tctcatagcc ataaaacatt
    31441 tccgatttca gaatcccaaa gaaggactcc accatagtgc ttctctgtga atgcctgttc
    31501 caacattgtt tgtacttgtt ctaagttggg tgaagttgaa agattatagg cgataatttc
//
LOCUS       DBERMM010000021        30127 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.021, whole genome shotgun sequence.
ACCESSION   DBERMM010000021 DBERMM010000000
VERSION     DBERMM010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 30127)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30127)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30127
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.021"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            120..293
                     /locus_tag="ACL8AS_001219"
     CDS             120..293
                     /locus_tag="ACL8AS_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229079.1"
                     /translation="MTKELQSSRYIVISFLVREMGIDIVEAISLMAELEKSGLVRLES
                     SGDLILKELGGAL"
     gene            290..1069
                     /locus_tag="ACL8AS_001220"
     CDS             290..1069
                     /locus_tag="ACL8AS_001220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000822769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="HGS1229080.1"
                     /translation="MKRITANQYHTSERYYKLPKILFEDEKYMDMKLEVKVAYSILKD
                     RLELSLSRGWIDEEGAVYLVFSNSKLMKLLGCSKSKLLSIKKILKEYDLIDEVQQSSS
                     EKGRLANKIYLGELSSTPVANSNRPSVKKRLGQDENETAPVSHSAPSETEVSETKYSE
                     TDSLFIEDEEERYTQPILKRKVEKVTKYDQDYIWGLVQDQFRREGFSETASEIAMTDF
                     ERIYQYALDNVRFVRRAEVLAEFVFNVLYSVWNNRVRKGGG"
     gene            1168..2526
                     /gene="dcm"
                     /locus_tag="ACL8AS_001221"
     CDS             1168..2526
                     /gene="dcm"
                     /locus_tag="ACL8AS_001221"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014947343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HGS1229081.1"
                     /translation="MRFIDLFSGIGGFRLGMESVGHECIGFCEIDKFARESYKSIFQT
                     EGEIEFHDIRDVSDDEFKKLRGKVDIICGGFPCQAFSIAGRRLGFEDIRGTLFFEIAR
                     AAKQIQPRFLFLENVKGLLNHDKGRTFTTILTTLDELGFDVEWQVLNSKDFGVPQNRE
                     RVFIIGHSRKKGTRLLFPFRREGQATNSETLKTLGNLNPSKSGMSGKVYYSEGLAPTL
                     VRGKGEGFKVAIPCMTPDRLEKRQNGRRFKENQEPMFTLNTQDLHGIVVVGDLPTSFK
                     ETGRVYGSDGLSPTLTTMQGGDKIPKILIPEPIHFLKIREATKKGYAQAEIGDSINLE
                     RPSSQYRRGRVGKGIANTLTTSGQMGVVVASYEGEDKQVYHVAGVLINGQFYRLRIRR
                     ITPKECFRLQGFPDWAFEAARKVSSNSQLYKQAGNSVTVPVIAAIAKKLKEIEEKDES
                     FK"
     gene            2510..2959
                     /locus_tag="ACL8AS_001222"
     CDS             2510..2959
                     /locus_tag="ACL8AS_001222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229082.1"
                     /translation="MKALNKESILDCDELETELHDAEIKQLDEQIFLMPNYLCEFEVT
                     FLDDYHKKHNYPLFYESYLQNVMEFLESQDIKNGADAFIDDNQNLVFVLYGQGYRAEG
                     KEGILTTQVTVKAYDEDKKSINFSDLLDSLIVSEYQMEPNLWEVSHD"
     gene            2952..3332
                     /locus_tag="ACL8AS_001223"
     CDS             2952..3332
                     /locus_tag="ACL8AS_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229083.1"
                     /translation="MIDLYLSKNNHRNQILLDFFQNYGIEVSCHSISEMTKDKLIEMM
                     SYSSDCFEFLSPNLLRFKNRDNLRLTDFIEMILKNPELSIRLPLAVSNKRVYPNLNLE
                     EARALLPRDTKQLIYMAQTHYLSN"
     gene            3345..3578
                     /locus_tag="ACL8AS_001224"
     CDS             3345..3578
                     /locus_tag="ACL8AS_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HGS1229084.1"
                     /translation="MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQK
                     IRHYKMEQRMPQSPWVERIVQVLDLDYEDLFRR"
     gene            3581..4168
                     /locus_tag="ACL8AS_001225"
     CDS             3581..4168
                     /locus_tag="ACL8AS_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="HGS1229085.1"
                     /translation="MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQILYSSSLIS
                     FLWMYGQRKQAHKVNMKSRMKWLGIGFVSLLIISLCFSLIHAQGTTNQANLIGLQHQV
                     PWFSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALAHHPGTILAWCLYV
                     SLGMFLGLVRYKSDLWGSMGLHLVWNLLVYSLLLF"
     gene            4458..5093
                     /locus_tag="ACL8AS_001226"
     CDS             4458..5093
                     /locus_tag="ACL8AS_001226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017649777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229086.1"
                     /translation="MTYTLEWLKTFDGEIDILNIKMNCLANTIEKNVSQYKYIYQTNM
                     ENCPEIILSVPNSSIPHLLGLSREHHVNLPTNNAGSIFEGLKDDWTLESLNKADNGWF
                     NENKFKIVGTLLLYQMLHVMECKFYTTDGILNRRVGSRFRRDNIYFVVFKLSNGISYT
                     VELSREQGNQYFPRSLKINDTSVTDCREIDLRLINKIRFKPVKARKVKWPS"
     gene            5447..5942
                     /locus_tag="ACL8AS_001227"
                     /pseudo
     CDS             5447..5942
                     /locus_tag="ACL8AS_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227923.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
     gene            6196..6492
                     /locus_tag="ACL8AS_001228"
     CDS             6196..6492
                     /locus_tag="ACL8AS_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HGS1229087.1"
                     /translation="MKTSKIILSVLTVIISCSLACPVFADWVSGGNWSYGGYHNPGNW
                     GAFSNYFHDYRWHWSSVTRASDSKANVGYASAHYTSRSFINTSFGETAYFNYGF"
     gene            6554..8563
                     /locus_tag="ACL8AS_001229"
     CDS             6554..8563
                     /locus_tag="ACL8AS_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="HGS1229088.1"
                     /translation="MKRLFIHFSNLFILIFLLWIAFISPNTVIHRSLPVIGILQQERE
                     VVYEELSSSLDQLAKENNSLIARQIQKTDSKGQVKFSYDIYGEGALPNGIKKEEKEFV
                     AKESLLTNYYILSGNLTLEKLDQKLHDLGFSKSFMNKPNPLQNFMVFFSSGSQSLALV
                     IFIISFAALTIIQKTLEMRSAGIRYISGIRRYQLFGHSLMEDGKELFLGCIGGSVLGA
                     ILIYYLQLTPFAYSLIISASIIYNTLLFILSAFLSFFFAFSIQTVHLVSLLKGKIPLK
                     RVLFFLFTCQFLAITVIGLSIHRVSIYGSIWQTYQEGSLAWSKETNWIQISLNRENVL
                     QTTNKEMQIEQIAKWSKLIESGIEKGGLLVHHQLAAFNSKGFMNDPRTGRELSITDYD
                     PLANTLYVTPNYLDIQRILVSPEEKERLNHLQAGEFGLLLPEKLKGQEEELKKRYEDY
                     LTPSDEQGKSQLPMKARVTYLPNNQKRFIYNNTPMIYQQFLTDPILVVVLPRSFGGYD
                     NPYFSHLNSYLYFDGLEKSKKLVVENGLEKNVSQYDYAASVYQQMIQSIQLENLITIA
                     GGIFAIATSILLFNTMNFLYFEEFRRPIFLKKIAGLGFVKIHQMILLSESILLLLGSF
                     LTFLLTQEWWIALVTLLLFITNAWFILLYRSHKEDHLLATVLKGA"
     gene            8565..9197
                     /locus_tag="ACL8AS_001230"
     CDS             8565..9197
                     /locus_tag="ACL8AS_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="putative bacteriocin export ABC transporter"
                     /protein_id="HGS1229089.1"
                     /translation="MISIEHLTKSFGQRTVFQDLSLQFTEGKVYALIGNSGCGKTTLL
                     NILAKLEPYEKGSISYQGQELKQIKQHHFFKHELGYLFQNFGLLENETIATNLDLGLI
                     GQKLTKKEKKQQEEEVLKKVGLAYLALDQKIFELSGGEAQRVALAKVILKDPPLILAD
                     ELTAALDPETSQEVMDLLLMLKNQERIIIIATHNPDIWNQADEVINLNQL"
     gene            9791..10090
                     /locus_tag="ACL8AS_001231"
     CDS             9791..10090
                     /locus_tag="ACL8AS_001231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000869756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229090.1"
                     /translation="MKVVNLYDLKQMGNKGGCTIQLIHHFPFGMGLGHLKRDYIEFKR
                     VGIFDGKAVEVTLREPYSRDLLQVVKSIKQRQKLIAYRYKEGKLLFVKKEASDVL"
     gene            10080..10568
                     /locus_tag="ACL8AS_001232"
     CDS             10080..10568
                     /locus_tag="ACL8AS_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229091.1"
                     /translation="MSSEQQERMAVQYAERSLLFTVKSLLKILEWSRRQALAQDSAYK
                     IGVQKLEELLQSPYSIDTINLKKDFLDKPIDIEKFKAFLEKEEIPLAIAWQGDSLHFY
                     TKDRSILDNHLDHLLEKMVNDPEKLADFIMDKSLDDAIDEAKSQITFRQEGAVKQKEM
                     VR"
     gene            10568..12445
                     /locus_tag="ACL8AS_001233"
     CDS             10568..12445
                     /locus_tag="ACL8AS_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VirD4-like conjugal transfer protein, CD1115
                     family"
                     /protein_id="HGS1229092.1"
                     /translation="MYSGKKFILFSLLGILLGYLFHRLTLLYDSYTGNTLDKWIHLLM
                     EGQDEVLQSPWNVSFTGKSSAFFLLGFVMMLLVYLYLETGKKQYREGVEYGSARFGTL
                     KEKKLFYGKEFLHDTILAQDVRLTLLDKKPPQYDRNKNIAVIGGSGSGKTFRFVKPNL
                     IQMNSSNIVVDPKDHLAEKTGKLFLEHGYQVKVLDLVNMKNSDGFNPFRYIETENDLN
                     RMLTVYFNNTKGSGSRSDPFWDEASMTLVRALASYLVDFYNPPKTREQLIEESRLSQK
                     EYKNLLKRQKKEVEERKKRGRYPSFAEISKLIKHLSKGENQEKSVLEILFENYAKKYG
                     TENFTMRNWADFQNYKDKTLDSVIAVTTAKFALFNIQSVMDLTKRDTLDMKTWGKEKS
                     MVYLVIPDNDSTFRFLSALFFSTVFQTLTRQADIDFKGQLPLHVRVYLDEFANIGEIP
                     DFAEQTSTVRSRNMSLVPILQNIAQLQGLYKEKEAWKTILGNCDSLVYLGGNDEDTFK
                     FMSGLLGKQTIDVRNTSRSFGQTGSGSLSHQKIARDLMTPDEVGNMKRHECLVRIANM
                     PVFKSKKYNSTKHPNWRYLANQESDERWWNYQINPLNQNQENHLEGLRIRDLTFESSL
                     K"
     gene            12466..12708
                     /locus_tag="ACL8AS_001234"
     CDS             12466..12708
                     /locus_tag="ACL8AS_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229093.1"
                     /translation="MFTHFKGFVYGVDASAMFAQAMSLLQKGLIAVGAFLVVVGIVNL
                     ATNIKDGGPGVRNAILEIVGGVMVGAAGAFVTQISI"
     gene            12725..13579
                     /locus_tag="ACL8AS_001235"
     CDS             12725..13579
                     /locus_tag="ACL8AS_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TrbL"
                     /protein_id="HGS1229094.1"
                     /translation="MNLSLVSPFVYLASEKISAENLFEGFNVDLQSTVDLIKSLSNYN
                     PTVWTYMSSITKSVMQPLGVAILSVVLILEFSKMAKKIANSGGAMTFEALAPMLISYI
                     MVAVVITNTTVIVEAIIGIASHAIEQVASIVAHGGAKYDTLSGLKGSGFIGRMIVGFF
                     ALLIWLVRIVSAAMVNLLVSIRFIQLYLMIPFAPLTIPTFLSDEWKSIGLGYLKNIMV
                     YAVQGVLIFLIVSLVPLFESAGKIAVSNGAGVLQSLAIMFGSLVQAILLIIALVGSQR
                     TARSILGM"
     gene            13633..13992
                     /locus_tag="ACL8AS_001236"
     CDS             13633..13992
                     /locus_tag="ACL8AS_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001097586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrgI family protein"
                     /protein_id="HGS1229095.1"
                     /translation="MNTRVFKDISKYQHRAWLGFTTRQIIFVLPAFIVTIIVLGLNLF
                     FWQFGDWFVYGFVFAFTIPLLLFGVYKPNDLYFEHYLKYRLHFELTIPLRTISGKKGL
                     EHEKKIKYIKETKDFND"
     gene            13943..16300
                     /locus_tag="ACL8AS_001237"
     CDS             13943..16300
                     /locus_tag="ACL8AS_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000824168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VirB4-like conjugal transfer ATPase, CD1110
                     family"
                     /protein_id="HGS1229096.1"
                     /translation="MKRKSNTLKKQKTSTTNKKEEVKDKKEEVLPSTANTLSYQALYQ
                     NGLMQVKEDYFSQSYLLGDVNYQTVGLEDKGAIIEKYSDLINSLDDQTNFQLTIFNKR
                     LNLEKFRHSVLYEEKEDGYDSYRKELNRMMNQNLDSGENNFSAVKLISFGRKDSNPKQ
                     AYRSLSQIGEYFKSGFSEIDARFGSLTGEERVNLLADMLRGEHHLPFSYRDLTRSGQT
                     TRHFIAPNLLDFKNKNYLQINDRLLQIVYVRDYGMELGDQFIRDLMQGDLELIVSLHA
                     QSSTKADAMKKLRTKKTLMESQKIGEQQKLARTGIYLEKVGHVLESNIDEAEELLKTM
                     TETGDKLFQTVFLIGVFGQDEEELKQALDTIQQVAGSNDLMIDKLPYMQEAAFNSLLP
                     FGCDFLEGVSRSLLTSNIAVNSPWTSVDLQDRSGKYYGINQISSNIITIDRSLLNTPS
                     GLILGTSGAGKGMATKHEIITTKIKESGENTEIIIVDPEAEYSVIGRAFGGEMIDIAP
                     DSQTYLNVLDLSEENMDEDPVKVKSEFLLSFIGKLLDRKMDGREKSIIDRVTRLTYQS
                     FKEPSLEEWVFVLSQQPEEEAQNLALDMELYVEGSLDIFSHKTNIQTGSNFLIYNVKK
                     LGDELKQIALMVVFDQIWNRVVRNQKLGKKTWIYFDEMQLLLLDKYASDFFFKLWSRV
                     RKYGASPTGITQNVETLLLDPNGRRIIANSEFMILLKQAKNDREELVQLLGLSKELEK
                     YLVNPEKGAGLIKAGSVVVPFKNKIPQGTQLFDIMSTDPDKMASN"
     gene            16312..19125
                     /locus_tag="ACL8AS_001238"
     CDS             16312..19125
                     /locus_tag="ACL8AS_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tip lysozyme"
                     /protein_id="HGS1229097.1"
                     /translation="MKDKREIIRARKAFRRSLKDEKKFLKQGKKEVRKQKKDSAVLDE
                     KAWKNEIKQKLENMREASKARVKQANEDYNHILQNSPPSLLNRKELRDRRLPHARKRL
                     KIAKKQFKEAKVEAKEERKESRKERKTNQKFFYGQETKVKSNFFLQGKNLEELKAKKE
                     VKAAKENLKSTKQAYKFKKISRKAKTFLYVLGREGGELASENEDLESYRTLHETIRKG
                     KRYSRLSYNLGKASVKTGQATGRFTKKRLTNTKERYHHFKDGKGWKLTKDNPSSFKNR
                     YRKLKKQGLLSVRNIYQKLKGAFSFFTFVAGNPVIWIVGGIVFLLLLMMSFFLGFSSA
                     SLIQQDEFELTKAYTHLTWEDAEHTRTNDKGITYYTKVDDVMGYMNFKFHDYELQKPV
                     HLFSSETYKDYLSALWHDLNDGEDLKSMQDLYETPKYKLSKDDQEEIKELKEEGVYAS
                     MQELDNPFEGKSNEDSLTMTYRYGYYDLDGKPTLQEYILLEAKAHQTIVAPMDGVVSL
                     DGDDVILTNGKGENESRLTLYSIHNGRAIEGTRVLTGDVIGETPDDTGLKVSYQKYKN
                     KKEKLVYVNPQFYFPKVIQLQTTILPAIGQFGGDEFERAKHIYDFLKSQGASPQAIAA
                     ILGNWSVESSINPKRAEGDYLSPPVGATDSSWDDETWLAIGGPAIYSGAYPNILHRGL
                     GLGQWTDTADGSTRHTALLNYARTQNKKWYDLDLQLDFMLHGDSPYYQSWLKDFFKNT
                     GSAANLAQLFLTYWEGNSGDKLLERQTRATEWYYQIEKGFSQTNGGQAKSDPQSLEGV
                     RGDLYEHSVPGGGDGMAYAYGQCTWGVAARMNQLGLKLKGSNGEKISIINTMGNGQDW
                     VATASSLGGETGSTPRAGAIVSFVGGTHGTPAIYGHVAFVEKVYDDGSFLVSETNYGG
                     NPNYTFRKISHADSAISFAYTTK"
     gene            complement(19156..19344)
                     /locus_tag="ACL8AS_001239"
     CDS             complement(19156..19344)
                     /locus_tag="ACL8AS_001239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229098.1"
                     /translation="MVYRVCKPPSQSVYSGVCHRLALTSKIAIGFRSGVRHRLALTSK
                     ITIRLTMSRPLIYTIYFT"
     gene            19364..19930
                     /locus_tag="ACL8AS_001240"
     CDS             19364..19930
                     /locus_tag="ACL8AS_001240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PBECR4 domain-containing protein"
                     /protein_id="HGS1229099.1"
                     /translation="MANSRDYRNPNYTETIKLQRFFTQLQIAASFFKEHFVGKIMYYE
                     TEIESVELHFSPTNFMHLCGVDYRKGAGSFFDDCLNRHVIIDELKIKKDGTTMQKLQV
                     LGSIGELLGKHVHLTGSGRYLYLEFDYALRTRKQIIALTLKETSRKIVPQSLLDLKRK
                     TVFPKGQKVISIYSKHLQTSELFYYLKD"
     gene            20082..20492
                     /locus_tag="ACL8AS_001241"
     CDS             20082..20492
                     /locus_tag="ACL8AS_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thrombospondin type 3 repeat-containing protein"
                     /protein_id="HGS1229100.1"
                     /translation="MEAIYQRDSDQDGLTDAQELALGTNPLSSDSDGDGRSDLVEIEE
                     GTNPLEKDLQDIDQTSITESSSVFMEMKQKISDMMESHYKEFILALISIETGIENQQD
                     LEDLYTYYMRMDAVSLLSSDLETSPQEVEMEIEL"
     gene            20540..25843
                     /locus_tag="ACL8AS_001242"
     CDS             20540..25843
                     /locus_tag="ACL8AS_001242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0140658 - ATP-dependent chromatin
                     remodeler activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SNF2-related protein"
                     /protein_id="HGS1229101.1"
                     /translation="MEVIQLLAMFRGTIPKDRDKMDLFLRYQAQHFDEKWQDLVESFL
                     TEEEKIEEIPHVYSFHQDIVSFLEASSENNDQDLESYTRNFGQAGLDKLSQLSNFEKN
                     LVLKVASYNLSTRFYIQSEKEKLTPLSELVFHQNQDVNLVNVYRVANNLSDRISRDIE
                     EFLLMVDSKEVKKEVPEIHFEEKEGDVLAYLGSELMATLDIVTDLVHHEENYIQLPLT
                     QKLKIITHFDEVKAKSEKSNQVEKILSPSSDIEQETEETNSFSNVDKIVEEALREYPI
                     GSQVSYKGQVFQLVSIENAQLNDLVRLELFNDSNQLFEENPILYLNSLEEIEQVLSHL
                     ELEKEDSEIEIDSSSESQEIDLFSYLEEENVNEKDKDKETKSLISGIEETDVPVLDFV
                     FPDDLEDFYPKTNREKIETNIAAIELVKRLEKERRQANPEEQELLAKYVGWGGLANEF
                     FDELNPKYETERLTLKSLVSKSEYSTIKQSSLTAYYTDPMIIRQIWQKLLDDGFEGGR
                     ILDPSMGTGNFFAAMPRSIREKSELYGVELDSVTGAIAKQLHPNTHIEVRGFEEVPYQ
                     NNSFDLVLTNVPFGNFRIADKNYDKPYMIHDYFVKHSLDLVRDGGQVSIISSIGTMDK
                     RTDNVLQEIKSNTHFLGGVRLPDTAFKKIAGTRVTTDLLFFQKDQAKNLNEEELVFSG
                     SVPFEEDKRVWINPYFDGKYNTQVLGEYEVRNFNGGTLNVKGESETLATDIMKALENV
                     EAPKQIDNSLKAPVFIQEEVDNSIPSHIRENLALYSFGYEGNQIYYRDTHGIRRSSKV
                     DEISYYVDEKGDFKAWDSSLSEHKIDRFVQLHLTDEEALDVYKSEEASKRGKYKGLFK
                     KTVFYESPLSDKDISRIKGMVDLRETYQALIEIQRHPDYSRTDFQVLLSKLNRDYDRF
                     VSQFGYLNVSVNRNLFDSDDKYSLLASLEDEYIDSKDQKVKYKKSLAFEKALVRPERV
                     ITRVSTALDALNSSLSDGRGVDIDFMVSIYPEHSQAAILDELGDQILMDPESYLRGER
                     NYLSKNQFLSGDILNKIEVVQLLVEENNQECDWTHALDLLESVRPPRIHLADIEFKIG
                     SRWIPQSVYGKFAFECFTNREFELSSPDVEQVIEVNPVDGQVHLRTPFAYRYPSAKDS
                     SLGVSGSRYDTGRKIFENLLNSNQPTITMTVTEGEKKKTITDLEKTSVLRAKEQHLQE
                     LFQDFVSRYPEVQQVIEESYNRLYNRTVSREYDGSHLVIDGLAQNISLRPHQENAIQR
                     IVEEKRALLAHEVGSGKTLTMLGAGFKLKELGMVHKPLYVVPSSLSAQFGQEIMKFFP
                     TKKVFVTTKKDFVKARRKQFVSRIITGDYDAIVIGDSQFEKIPVSKERQMNYIEDKLN
                     ELREIKTHSENKYTVKEAEQSISGLEKQLEELQRFNRDSFIDFENLGIDFLFVDEAHY
                     FKNIRPITGLGNVAGITNTTSKKNVDMEMKVRQIQEEHDFKNIVFATGTPVSNSISEL
                     YTMMNYIQPDILKRYQVDYFDSWVGAFGEIQNSMELAPTGDKYQPKKRFKKFVNLPEL
                     MKIYKETADIQTQDMLDLPVPEAHIIPIESELTENQKLYLEELVMRSDAVKCGTVDPS
                     QDNMLKITGEARKLAIDMRLLDSSYSLADNHKLLQVVDNVERIYREGMENKATQMIFS
                     DIGTPKKKDNGFDVYSEIKALLVDRGIPSMEIAFVHDANSDEKKNSLSRKVNAGEVRV
                     LLASTEKGGTGLNVQSKMKAVHHLDVPWRPSDIQRASVKAV"
     gene            26407..28218
                     /locus_tag="ACL8AS_001243"
     CDS             26407..28218
                     /locus_tag="ACL8AS_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006740542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="reverse transcriptase domain-containing protein"
                     /protein_id="HGS1229102.1"
                     /translation="MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYA
                     HPGHLTPGVDELTIDGMSIARIDQLIDSLKDESYQPHPSRRTYIPKKNGKLRPLGIPS
                     FDDKLLQQVIKMILEAIYEGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIK
                     SFFDNINHDVMIHILRERITDERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPI
                     LANIYLDKFDKYMTDYVKNFCQGKYRKRTPEYRQNEIELGKARRALEYVSTENQRQEV
                     IQRIRQLEKERVLIPHSDPMDSSFKRLTYTRYADDFICGVIGSKEDALRIKADIKDYL
                     EAVLKLELSVEKTLITNARDKAKFLGYHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVS
                     IETIRDRLLSYGAMKMTYHRGYEVWKPTARYFMKDCDDLEILERYNAEIRGFYNYYCI
                     ANNSSILHRFKYIMEYSMYKTYATKYRTTKSHIIRKYKKDGQFRVQYIGRKGDTMTRY
                     FYNGGFKRQKKSFLDNDNLPNTAKYFSRTNLIDRLKASRCEYCQATDSSLEIHHVRKL
                     KDLKGKTFWERLMISRQRKTIALCKDCHKKLHHGKLD"
     gene            28326..29270
                     /locus_tag="ACL8AS_001244"
                     /pseudo
     CDS             28326..29270
                     /locus_tag="ACL8AS_001244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453515.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helicase SNF2"
     gene            29345..29629
                     /locus_tag="ACL8AS_001245"
     CDS             29345..29629
                     /locus_tag="ACL8AS_001245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5962 family protein"
                     /protein_id="HGS1229103.1"
                     /translation="MMEDTYYQLEEALVQGFQTPEEYQAYKELKEHYEEVTGDYSFSK
                     RELTSQLEIALQNHQGVDFEEHEKEEYLDLVQKLEEFDSSLATHYRQLID"
     gene            29643..29939
                     /locus_tag="ACL8AS_001246"
     CDS             29643..29939
                     /locus_tag="ACL8AS_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000998899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5966 family protein"
                     /protein_id="HGS1229104.1"
                     /translation="MNDLLLIPVIFLAVGGIIILLWRLFLIASGLFLIGFVSFLIFVE
                     VYGIYLFFTEPSLYFDDIRQYGLTSFTAVYLFINLMLVLGFSWRFINSINKHKM"
BASE COUNT        10128 a         4785 c         6167 g         9047 t
ORIGIN      
        1 atttagtttc ctaccaaaaa ccctaccaaa aattaatttg gcagggtttt tctttttaac
       61 aaatttatcg tggagaacaa ttgaatattg ttctcctttt tttattttca ggagggaaaa
      121 tgacaaaaga attacaatca tcacgctata ttgtcatttc atttttagta cgtgaaatgg
      181 gaattgatat tgttgaagcc atctctctta tggcagaatt agaaaaaagt ggcttggttc
      241 gattggaatc aagtggagat ttaatactca aagaactagg aggagctcta tgaaacgaat
      301 taccgcaaat caataccata cttcagaacg gtattataaa ttacctaaaa ttctttttga
      361 ggatgaaaaa tatatggata tgaaactaga agtaaaggtg gcttattcta ttttaaaaga
      421 tcgtttagaa ttatctctca gtcgtggttg gatagatgaa gaaggggcgg tttatttagt
      481 attttctaat tctaaactga tgaagttgtt aggttgttct aagtcaaaat tactgtctat
      541 caaaaaaatt cttaaagaat atgacttaat tgatgaagtt caacagtctt caagtgagaa
      601 agggagactt gctaataaga tttatttagg ggaattgtct tctaccccag tagctaattc
      661 aaacaggcct agtgttaaaa aaagactagg gcaggatgaa aatgaaacgg cccccgtctc
      721 acattcagcc cctagtgaga ctgaagttag tgagactaaa tatagtgaga ctgattcttt
      781 atttattgag gatgaggagg agaggtatac tcaacctatc ttgaaaagaa aagtagaaaa
      841 ggtcacaaaa tatgatcaag attatatttg gggattggta caagatcaat ttagacgaga
      901 aggtttttct gaaacagcca gtgaaattgc tatgactgat tttgagagaa tctatcagta
      961 tgctcttgac aatgttcgct ttgttagaag agcggaagta cttgctgaat ttgtgtttaa
     1021 tgtcctgtat tctgtttgga ataaccgtgt tagaaaagga ggtggttaga tgtcgtcaat
     1081 cgagtggata ttagttttgc tcattttcat ttcaagtggt gtgacacttt ggatattgat
     1141 agtcgatcag aaaggggtaa tcaagaaatg agatttattg atttattttc aggtataggt
     1201 ggttttcgac ttggaatgga aagtgtagga cacgagtgta ttggattttg tgagattgat
     1261 aaatttgcta gagaatctta taaatccatt tttcaaacgg aaggagaaat cgaatttcat
     1321 gacatacgag atgtttcaga tgacgaattt aaaaaactta gagggaaagt cgatatcatc
     1381 tgtgggggat tcccttgtca agcattttca atcgcaggaa gacgattggg atttgaagat
     1441 attagaggaa ctttgttctt cgaaattgct cgggcggcca aacaaatcca accacgtttt
     1501 ctttttcttg aaaatgttaa aggcttactc aatcacgata agggacggac gttcaccaca
     1561 atccttacca cacttgatga gttggggttt gatgttgagt ggcaggtgct taacagtaag
     1621 gattttggcg ttccccaaaa cagagagagg gtgtttatta tcggacattc tagaaagaaa
     1681 ggtacccgac tcctatttcc tttcagacga gaaggtcaag caactaactc tgagacttta
     1741 aaaacactag gaaatttgaa tccatcaaaa agtggcatga gcggtaaagt ctattattca
     1801 gaggggttag cgccaacatt agttcgtgga aaaggagaag gatttaaagt tgcgattcct
     1861 tgtatgacac cagacagatt agaaaaaaga caaaatggta gacgatttaa ggaaaaccaa
     1921 gagccaatgt ttactttgaa tactcaggat ctccatggta ttgttgttgt tggagattta
     1981 ccaactagct ttaaggagac tggtcgcgta tatggaagtg atgggttatc tccaacacta
     2041 actacgatgc aaggtggaga taaaattccc aaaatactga tcccagaacc aatccatttt
     2101 ctaaaaatca gggaagcaac taaaaaaggg tacgctcaag cagagattgg agattcaatc
     2161 aatttagaaa gaccaagttc tcagtatcgg cgtggtagag ttggaaaagg tatagcgaat
     2221 acgttgacaa ctagtggtca aatgggagta gtagtggcta gctatgaagg agaagataag
     2281 caagtttacc atgtagccgg tgttttaatt aatggacaat tttaccgttt gagaatacga
     2341 cgaatcactc ctaaagagtg ttttcgattg caggggtttc ctgattgggc ttttgaagct
     2401 gctagaaaag tctctagtaa tagtcagctc tataaacaag ctggtaatag tgtaaccgtt
     2461 cctgtgattg ctgcaatcgc aaagaaatta aaagaaatag aggaaaaaga tgaaagcttt
     2521 aaataaagag tcaatactag attgtgacga attagaaaca gaattacatg atgcagaaat
     2581 caaacagctg gatgaacaaa tatttttaat gcccaattat ctatgtgagt ttgaagtgac
     2641 atttttagat gattaccata aaaaacataa ctatccacta ttttatgaat cctatcttca
     2701 aaacgttatg gaattcctcg aaagtcagga tataaagaac ggagctgatg cctttataga
     2761 tgataatcag aatcttgttt ttgttttata tggacaaggc tatcgagccg agggaaaaga
     2821 gggaatactt acaacccaag taactgtaaa agcctatgat gaagacaaga aatcaattaa
     2881 cttctcagat ctattagatt ccttaatcgt ctcagaatat caaatggaac cgaatctttg
     2941 ggaggtctcc catgattgat ctctatctaa gtaaaaataa ccatagaaat caaattcttt
     3001 tagatttctt tcaaaactac ggaatagagg tatcttgtca ttcgatttct gaaatgacaa
     3061 aggacaaatt aattgagatg atgagctatt cttcagattg ttttgagttt ttatctccta
     3121 atttattacg atttaagaac cgtgacaatc taagattaac ggatttcatc gaaatgatat
     3181 taaaaaatcc tgaactaagc atcagacttc ctcttgcagt ttcaaataag agagtttatc
     3241 caaatctgaa tttggaagag gctagagctc tattgccaag agatacgaaa caattgattt
     3301 acatggcaca aacacattat ttatctaact aaaggagaag caatatggct gaacgatttt
     3361 gggagaactt gtccattatt ttagctgaaa gaaatattag ctggattgag ttaaccagaa
     3421 aaatgtttgc gggagagttt cactatccaa gtgaattgaa tcgtttgtat caaaagattc
     3481 gtcactacaa gatggaacaa cgaatgcctc aaagtccatg ggtagaaagg attgtgcagg
     3541 tattagattt agattatgaa gatttatttc ggaggtaact atgaaaagaa taattccagt
     3601 ttatatattc caacaagtaa atgtcctatt ggtatctcta tacttattga aatttctttg
     3661 tatcggtgag ttaactatac tacagattct ctatagttcg tcactcattt cttttttatg
     3721 gatgtatggt caacgcaaac aagctcataa ggtcaatatg aaatctagga tgaaatggct
     3781 tggtattgga ttcgttagcc tactgattat aagtctatgt tttagcctaa tccatgctca
     3841 aggaactacg aatcaagcaa acttaattgg ccttcaacat caagtccctt ggttttcatt
     3901 tttattgttc ttaatcaatg cgagtatggt tgaagaattt ctgtatcgag aaattttatg
     3961 gaacttggtt agaaaattag atattcgagt tgctttgaca agtgttttat ttgccttagc
     4021 acatcatcca ggaaccattc tagcttggtg tttatatgtt tcacttggga tgtttttagg
     4081 gcttgtacgc tacaaatcgg acttatgggg cagtatgggg ctacatttgg tgtggaacct
     4141 actagtttat agtttgctgc ttttttaaaa taggtgacct gatttttaga tattcataat
     4201 gaatgtaatt gttgacaaat atggactaat tgcgtataat gaagataatt aaatgatata
     4261 attacttgtg ggctagtgga tatggtctgc acccgcctgt gggctccgct ctcagttcag
     4321 actgtttgtt gagaaaaaga atagcaggac tgcctaccct tgaggaatag atagggcata
     4381 tctagcgtga ggtgaaactc aatacgtggg agagaaggaa gcaggagctt ccttctcttt
     4441 tttaggagaa aattcaaatg acttatactt tggaatggct aaagactttt gatggagaga
     4501 ttgatattct caatattaag atgaattgct tggccaatac tattgagaaa aatgtttctc
     4561 agtacaaata tatttatcag acaaatatgg agaactgtcc tgaaattatt ctatcagtcc
     4621 caaactcctc cattcctcat ctattaggat tatctagaga acatcatgtt aatttaccaa
     4681 ctaataatgc agggagtatt tttgaaggat taaaagatga ttggacattg gaaagcctga
     4741 ataaagctga taatggttgg ttcaacgaaa ataaattcaa aatagttgga accttgttgc
     4801 tttatcaaat gttacatgta atggagtgta aattctatac aactgatggc attttgaata
     4861 gaagagttgg tagccgattt agaagagata atatttattt tgtagtcttt aaattaagta
     4921 atggtattag ttatacagta gaactatcac gtgaacaagg taatcaatac tttccaagaa
     4981 gccttaaaat caatgatacc tccgttacag attgtagaga aatagatctt agactcatta
     5041 ataagattag atttaagcca gttaaggcaa gaaaggtgaa atggccatca tgatttaaaa
     5101 attgaaatca tgattacatc actattcttt tcttaacaaa tgtgagtatt gtcgaagaat
     5161 ttctgtatcg agaaatttta tgaaagttaa tcagaaaatt agatatcaga gtttctttga
     5221 caagcatttt atcttgctgt ttgtatgttt ttactagaaa tgtttctagg gcttcatttg
     5281 gagtggaaac tattagtcca tggcttactt cttctttata ataggtggtc tagcttactt
     5341 atagattcag tttgaaataa aaaactaaat gaattgattt taaagaaata aaatgctaac
     5401 agatatataa gatgttagca ttttatttct aagaaaggag aatgaaatgg ttgataaaag
     5461 agaaaaactg atgaactctt tcaatcagta tggtttttta acttttaaac aagtaataga
     5521 tgaaaattta cactacaaaa ccttattgaa aatgcttgca gaaggaaaaa tcgatgctga
     5581 agaaaaaggg ttatatcgct tacctgatat ttatttagat gagtggtttg tccttcagta
     5641 tcgatttcca aagggaatct tttctttgga gacagcactt tggttacatg gtttatcttt
     5701 gactatccct tttaacatga cgatgagttt tccttatggt acgaatacca aaaacattaa
     5761 ggaagcagat atatgtccta ttattttacg ctctcactat agtgaaggaa ttattgaaat
     5821 agagcgcctt cctggtcaat ttattaaagt ttatgaagtt gaacgagttt tggttgaatg
     5881 tctatgccca gctatttaaa gtaactgata agttacaatc ttatacggag gtgctatctt
     5941 aatgtttttt aatacaaaaa ctttaatagt tttagaattt ggttgatagc ttatgaataa
     6001 acagctatat tgttttgatt attaaatatt caaaaatcta ttatataatt agttgaaatt
     6061 atatgttgta agtgttataa tgcaggcgaa aagggttgct ctggaaagga gaaaaaacgg
     6121 aaactatatt ttgagcaatt cataatttta ttgttaaata aagcttttaa ttctaattat
     6181 ggaaggtgaa cagtcatgaa aacgagtaaa attatccttt ctgtcttaac tgtaattatt
     6241 agttgtagct tagcgtgtcc tgtatttgct gattgggtat ctggtggtaa ctggagttac
     6301 ggaggttatc ataatccagg caattgggga gcattctcaa attatttcca cgactatcga
     6361 tggcattggt caagtgtgac tcgagcaagt gacagcaaag ctaatgtagg ttatgcttct
     6421 gctcattaca catcaagatc gttcataaat acaagttttg gtgaaactgc atactttaat
     6481 tatggatttt aattgctaaa gtttatccta gagagaagaa atctctctag ggtaaactag
     6541 aaagagtaga attatgaaac gtttatttat acatttctcg aaccttttta ttctaatctt
     6601 tctgctttgg attgccttta tttcacctaa tacggtcatc catcgaagcc tacctgtaat
     6661 agggattctt caacaagaaa gggaagttgt ttatgaagag ctttcatcta gcttagatca
     6721 gttagcaaaa gaaaacaata gtttgattgc tcgtcagatt caaaaaacgg attctaaagg
     6781 gcaagtcaag ttttcgtatg atatctacgg agaaggagca cttcctaatg gcatcaaaaa
     6841 agaagagaaa gaattcgttg caaaggaaag tttgcttacc aattactata tactatctgg
     6901 gaatttaacc cttgaaaaat tagatcaaaa actccacgat cttggttttt caaaaagttt
     6961 catgaataag cccaatcccc tgcaaaattt tatggtattt tttagttcgg gttcccaatc
     7021 tctagccttg gttattttta tcatcagctt tgctgcattg accattattc aaaaaacact
     7081 tgaaatgaga agtgcaggga ttcgttacat ttctggaata agacgatacc agctctttgg
     7141 acattctctc atggaagacg gtaaagaatt gtttttaggg tgtattggtg gaagtgtcct
     7201 aggagctatt ctgatttatt atttacaatt gactcctttt gcctattctc tcatcatttc
     7261 agctagtatt atttacaata cacttttatt tattttatct gctttcctat cctttttctt
     7321 tgcattcagt attcagacag tacacttggt tagcctttta aaggggaaaa ttccattaaa
     7381 aagagtcttg ttttttctct ttacatgtca atttcttgca atcactgtca ttggtctctc
     7441 aattcatcgt gtcagcatct atggctctat ctggcagact tatcaagagg gaagtttggc
     7501 ttggtctaaa gagacaaatt ggatacaaat tagtttgaat cgggaaaatg ttttacaaac
     7561 gacaaacaaa gaaatgcaaa ttgaacaaat agctaaatgg tctaaactga tcgagtctgg
     7621 cattgaaaaa ggtggacttt tggtccatca tcagcttgcc gcatttaatt caaaaggctt
     7681 catgaacgat cctagaacag ggagagagct ttcgatcaca gattacgatc ctcttgccaa
     7741 caccctgtat gtaacaccaa attaccttga tatccaaagg atcttagttt cccctgagga
     7801 aaaagagcgc ttgaatcact tgcaagctgg agaatttgga ctcttgcttc ctgaaaagtt
     7861 gaaagggcaa gaagaggagt tgaaaaaacg ctatgaagat tatctgactc ctagtgatga
     7921 acaaggaaag agtcagttgc ctatgaaagc acgggtgacc tatcttccta acaaccaaaa
     7981 acgatttatc tataataata caccgatgat ctatcagcaa ttcttgacag acccgatttt
     8041 ggttgttgtt ctacctagaa gctttggtgg ctacgataat ccttatttct ctcatcttaa
     8101 ttcttatctt tactttgatg gtctggaaaa aagcaagaaa ctagtagttg agaatgggct
     8161 tgaaaaaaat gttagtcaat atgactatgc ggcgtctgta taccagcaga tgatccaatc
     8221 cattcaatta gagaatctca ttaccattgc aggaggaatc tttgcaatag ctacttccat
     8281 actactcttt aacaccatga atttcctcta ttttgaagag tttagaagac caatcttctt
     8341 gaagaagatt gcaggtctgg gatttgtaaa gattcaccaa atgattttgc tctcagaaag
     8401 tatcctctta ctattaggaa gcttcctgac attccttctc actcaagaat ggtggattgc
     8461 tcttgtcact ctcttgctat ttattactaa tgcttggttt attctcctgt accggtctca
     8521 taaagaagac cacttgttag ccactgtact gaaaggagcc taatatgatt agcatagaac
     8581 atttaaccaa atcatttggc caacgaacgg tctttcaaga tttgagcttg caatttacag
     8641 aaggtaaggt ctatgctctg atcggaaata gcgggtgtgg taaaacaacc ttgcttaata
     8701 tcttggcaaa gttagagcct tatgaaaagg gaagtatcag ctatcaaggg caagaattga
     8761 aacaaatcaa acagcatcac ttctttaagc atgaattagg ctatctcttt caaaactttg
     8821 gcctacttga aaatgagact atcgctacaa atttagattt gggattgatt gggcaaaaat
     8881 taacgaaaaa agagaagaag cagcaagaag aagaagtgct caaaaaagta ggattggctt
     8941 accttgctct ggatcaaaag atttttgaat tatctggggg agaggcgcaa cgtgtcgcat
     9001 tagctaaagt tattttaaaa gatccacctt taattttggc agatgaacta actgcagcac
     9061 tggatccaga aacctcacaa gaggtgatgg acttgctctt aatgttaaag aatcaagagc
     9121 gtataatcat tattgcaacc cataatcccg atatttggaa tcaagcagat gaagttataa
     9181 atttaaatca attatagtta cagtcaatag atatcttcta tattttaaag ttattttatc
     9241 tgaatccgta aaagcagttc aattgaactg cttttttctt ctacgactta cactgtttgg
     9301 tttcatgagc aagcccctca aagtgaatta ataacaaatc attagaagtc atagtgatga
     9361 aatttctgta acggaagtag agcgaattgc tgaaccatta aatgagtatc tctcgaagta
     9421 gaagcgtcta ttttgacttt tagtttgata gaatggtagt ttgaaaatgt aaatgatagc
     9481 tactgttcat aaaacatata aggtacgtac ggtgttgtga gaggagctag aaattagcac
     9541 ttaccttatt attccaacaa ccccaaaaat gtgataaaaa tttcaactac tcttatctat
     9601 aataaagcta cctgttcttt gaaaattgaa tccactccgt cttgattagc gtgcctgtgt
     9661 aagtagggac tgagagtatt tccctgtgaa gggcgactgg cacaagacgt gtgtgagaat
     9721 tttctaacag acacggagtt tatcgttacc agacttaaac gatgcgacaa actagataaa
     9781 ggagttaatc atgaaggtag taaacttgta tgatttgaaa caaatgggaa ataaaggtgg
     9841 ttgtaccatc caattgattc atcactttcc ttttggtatg ggcttaggac atctcaaaag
     9901 agactacatt gaatttaaac gtgttggtat ctttgatggg aaagcagtag aagttactct
     9961 tcgagaacct tattcgagag atctactgca ggttgtcaag tcgattaagc aacgtcagaa
    10021 attgatagct tatcgttata aagaaggaaa gctgctattt gttaagaagg aggcatcaga
    10081 tgtcctctga acaacaggaa cgaatggcag ttcaatatgc tgagcgtagt cttttattta
    10141 ctgtaaaaag tcttttaaag attctagaat ggtctagacg tcaggcttta gcacaagatt
    10201 ccgcctataa gataggggtg cagaaattag aagaattgct acaatctccc tattcgattg
    10261 atacgattaa tctgaaaaaa gattttttag acaaaccaat tgatatagag aaatttaaag
    10321 cttttttaga aaaagaagag attcctttag ccatcgcttg gcaaggggat tctctgcatt
    10381 tctacacgaa agaccgttcg attctagaca atcatttaga ccatctgtta gaaaaaatgg
    10441 ttaatgatcc ggagaaatta gctgatttta tcatggataa gtcattagac gatgcaattg
    10501 atgaggctaa atcccaaatt acctttagac aagaaggtgc cgtcaaacag aaagagatgg
    10561 tgagatgatg tacagtggaa agaaattcat actattctca ctgttaggta tcttactagg
    10621 ctatcttttt catcgtttga cgcttttgta tgattcctat actggaaata cattagataa
    10681 atggattcat cttctgatgg aaggtcaaga tgaagttctt cagtcgccat ggaatgtttc
    10741 ctttactgga aaatcaagtg ctttttttct actaggcttt gtgatgatgt tgctggttta
    10801 tctctatcta gagactggta aaaaacaata ccgagaaggg gtagaatacg ggagcgcccg
    10861 ttttggaact ctaaaagaaa agaagctctt ttacggtaag gaatttttac atgatacgat
    10921 cttagcacaa gatgttcgtt tgacattatt agataaaaaa ccaccccaat atgatagaaa
    10981 taagaatatt gcagtgatcg gaggttcagg aagtgggaag acatttcgct ttgtgaaacc
    11041 caatctaatt cagatgaata gttctaatat tgtagtggat cctaaagatc acttggccga
    11101 gaaaacagga aaactctttt tagaacatgg ctaccaagta aaggtgttag atttagtcaa
    11161 tatgaagaac tcagatggct tcaatccttt tcgctatata gagacagaaa atgatttgaa
    11221 tcgcatgctg acggtttatt tcaataacac caaaggctct ggctctcgta gtgatccatt
    11281 ttgggatgaa gcttctatga ctttggtccg agctttagcc tcctacttgg tcgatttcta
    11341 taatccaccc aaaacaagag aacagctcat agaagaaagt cgtttaagtc aaaaagaata
    11401 caaaaacttg ttgaaacgtc aaaaaaaaga agtggaggag cgaaaaaaac gagggcgtta
    11461 tccaagtttt gctgaaatct caaaactcat taaacactta tccaagggtg aaaaccaaga
    11521 aaaaagtgtc ttagaaattc tatttgaaaa ttatgctaaa aagtatggga ctgaaaattt
    11581 taccatgcga aattgggcag attttcaaaa ttataaggat aagactctgg attctgttat
    11641 agctgtaacc actgctaaat ttgccctctt caatattcag agtgtcatgg atttgaccaa
    11701 aagagatact cttgatatga agacatgggg caaggaaaaa tcaatggttt acttagttat
    11761 cccagataac gatagtacct ttcgctttct ttcagccctc tttttttcaa cagtatttca
    11821 aactctaaca agacaagcag atattgattt taaggggcaa ttacctcttc atgtgagagt
    11881 ctacttagat gaattcgcaa atatcggaga aatcccagat tttgctgaac aaacctcaac
    11941 agtccgttct cgaaatatga gtctcgttcc tattctacaa aatattgccc aacttcaagg
    12001 gctctataaa gaaaaagaag cttggaaaac cattcttggg aactgtgata gcttagtata
    12061 cttaggtggt aatgatgaag atacctttaa atttatgagt ggtttactcg gtaaacaaac
    12121 cattgatgtt cgaaatacta gtcgttcctt tggccagaca ggttcaggat ccctttctca
    12181 tcaaaagatt gctcgtgatc taatgacacc cgatgaggtc ggaaatatga aacggcatga
    12241 atgcttggtt cgaattgcca atatgcctgt ctttaaaagc aaaaaataca attcaaccaa
    12301 gcatccaaac tggaggtacc tagccaatca agaaagcgat gaacggtggt ggaactatca
    12361 aatcaatcct ttgaatcaaa atcaagaaaa tcatcttgaa ggccttagaa ttcgtgattt
    12421 aacttttgaa tctagtttaa aataaaaata gaaaagagga aatacatgtt tacgcatttt
    12481 aaaggttttg tttatggagt agacgcaagt gctatgtttg cacaagctat gtctttgtta
    12541 cagaagggat tgattgccgt tggtgccttt ctcgttgttg tggggattgt caatcttgca
    12601 accaacatta aagatggagg accaggtgtt cggaatgcca ttcttgaaat tgtcggtgga
    12661 gttatggtcg gggctgctgg agcctttgta acccagattt caatttagga ggataaacaa
    12721 tgacatgaat cttagtttag tctcaccctt tgtttacctt gcatctgaaa aaatatcagc
    12781 tgaaaattta tttgaaggat ttaatgtaga tttacaatct acggtagatc tgattaaatc
    12841 actatctaac tacaatccaa ccgtttggac ttatatgtct agtattacta aaagtgtcat
    12901 gcagcccctt ggagttgcga ttttatcggt tgttctcatc ctagaatttt cgaagatggc
    12961 taagaaaatt gctaactctg gtggagcgat gacctttgaa gccttagcgc caatgctgat
    13021 tagttatatt atggtcgcag ttgtaattac caacactacc gtcattgtag aagccatcat
    13081 cgggattgcg agtcatgcca ttgaacaagt ggcctcgatt gtggctcacg gtggggcaaa
    13141 gtatgataca ctctctggat taaaagggtc aggatttatt ggccggatga ttgtgggctt
    13201 tttcgccctc ctcatttggc ttgttcggat agtaagtgca gccatggtta atcttttggt
    13261 atctattcga tttattcaac tctaccttat gatcccattt gcccctctta cgattccaac
    13321 atttttaagt gatgaatgga agtctattgg tttaggctat ttaaaaaata ttatggtcta
    13381 tgcggtacaa ggggttctta tttttctgat tgtttctctt gttcctttgt ttgaatctgc
    13441 tggtaaaata gctgtttcaa atggtgcagg agtcctgcaa tcacttgcga ttatgtttgg
    13501 tagtttggta caagctatct tactgattat tgccctcgtt ggttctcaac gtacggctcg
    13561 ctcaatctta ggtatgtaat tagataaagg ctaggaagtg gttgcttctt agccttttta
    13621 gaaaggaaag tcatgaatac acgtgtcttt aaagacatct caaaatacca acacagggct
    13681 tggttaggtt tcaccacaag acaaatcatc tttgttttac cagcctttat tgtcacaatt
    13741 attgttttgg gcttgaatct ctttttctgg caatttggag attggtttgt ttacggtttt
    13801 gtgtttgctt ttaccatccc cctcttgctt tttggagtct ataaacccaa tgatttatat
    13861 tttgaacatt atttgaaata ccgtcttcat tttgaactaa cgatacccct acgcacaatt
    13921 tcaggaaaga aaggacttga acatgaaaag aaaatcaaat acattaaaga aacaaaagac
    13981 ttcaacgact aataaaaagg aagaagttaa agataaaaaa gaggaagtgt taccatcaac
    14041 ggctaatact ctttcctatc aagccttgta tcaaaatggt ctgatgcagg taaaagaaga
    14101 ttatttttca caaagctatt tacttggtga tgtcaattac cagaccgttg gtttagaaga
    14161 taagggagca atcattgaga agtattctga tttgattaac tctttagatg accaaaccaa
    14221 cttccaattg accattttta ataaaagatt gaatttagaa aaattcagac acagtgtttt
    14281 gtatgaggaa aaagaagatg ggtacgatag ctatcgtaaa gaattgaatc ggatgatgaa
    14341 tcaaaattta gatagtggtg aaaataactt ttcggctgtg aaactgatta gttttggtag
    14401 aaaggattct aatcccaaac aagcttatcg ttccttgtct caaataggcg aatatttcaa
    14461 gagtggtttc tcagaaattg atgctcgatt tggatccttg actggagaag aacgggtgaa
    14521 cttgttggca gatatgctta gaggagaaca ccatcttcct ttttcttatc gtgatttaac
    14581 gagatctggc cagacaactc gtcacttcat agcacctaat ctcttggatt ttaaaaacaa
    14641 gaattaccta caaatcaatg accgcttatt acagattgtc tatgtgagag actacggtat
    14701 ggaattaggg gatcagttta tccgagacct catgcaagga gatctggaat tgattgtaag
    14761 ccttcatgct caaagttcga ccaaggcaga tgccatgaag aaactacgaa caaagaaaac
    14821 cttaatggaa tcccaaaaga ttggggaaca acaaaaacta gctcgtacag gtatctattt
    14881 ggaaaaagta ggtcatgtat tagaaagcaa tatcgatgaa gctgaggaac tcttaaaaac
    14941 catgaccgag acaggagata aactatttca aacggtcttc ttgattgggg tctttggtca
    15001 ggatgaagaa gaactcaaac aagccctaga cactatccaa caagtggccg gctcaaatga
    15061 cctaatgatt gataaacttc catatatgca agaagcagcc tttaatagtt tgctgccatt
    15121 tggttgtgat tttttagagg gagtatcacg gagtttatta acgtccaata tagcagtgaa
    15181 ctcaccttgg acttcagtag acttacaaga ccgtagtggg aaatattatg gtatcaatca
    15241 aatctcaagc aatattatta ccattgatcg cagcctatta aatacaccgt ctggtctgat
    15301 tttaggaaca tctggagctg ggaaagggat ggcaactaag catgaaatta tcacgaccaa
    15361 aatcaaggaa tctggtgaaa atactgaaat tatcatcgtg gatccagaag cagaatacag
    15421 tgtcattgga cgagcttttg ggggagaaat gattgatatt gcgcccgatt cccaaactta
    15481 tctcaatgtc cttgacttgt ctgaggaaaa tatggatgag gatcctgtaa aggtaaaatc
    15541 agaatttctt ttatctttta ttggcaagtt attggataga aaaatggatg ggagagaaaa
    15601 atcgattata gaccgagtca ccagactcac ctatcagtca tttaaagagc cttctttgga
    15661 agaatgggtc tttgtcttga gccaacaacc agaagaagaa gcgcagaatt tggcacttga
    15721 tatggaactg tatgttgaag gttctcttga tattttttct cataagacca atattcagac
    15781 aggatctaac ttcttaatct ataacgttaa aaagttagga gatgagctga aacaaatcgc
    15841 tcttatggtt gtttttgatc agatatggaa tcgtgtcgtt cggaaccaaa aattagggaa
    15901 gaagacttgg atttattttg atgaaatgca gcttctttta ttagataaat atgccagtga
    15961 tttcttcttt aaattgtgga gtcgtgtcag aaaatatgga gccagtccga ctgggataac
    16021 ccaaaatgtc gaaaccttat tgttagatcc aaatggtaga cggattattg ccaatagtga
    16081 atttatgatt ctcctcaagc aagcaaaaaa tgaccgagaa gaactagttc aactcttagg
    16141 cttgtcaaaa gaactcgaaa aatacctagt caatccagaa aaaggggcag gactaataaa
    16201 agctggttca gttgtcgttc cctttaaaaa taagattccc caaggtacac aattgtttga
    16261 tatcatgagt acagatcctg ataaaatggc ttctaattaa ggggaaggta aatgaaggat
    16321 aagagagaaa tcatacgtgc ccgaaaggca tttagaagaa gtctaaaaga tgagaagaaa
    16381 ttcttaaaac aaggaaagaa ggaggtgaga aaacagaaaa aagattccgc tgtactggat
    16441 gaaaaagcat ggaaaaatga gataaagcaa aagctggaga atatgagaga agcttcaaag
    16501 gctagagtaa aacaagcaaa tgaagactac aatcatattc ttcaaaatag tcctccatca
    16561 cttttgaatc ggaaagaatt aagagataga cgattgcctc atgctaggaa acgattgaaa
    16621 atagccaaga aacaatttaa ggaagctaag gttgaagcaa aagaagaaag aaaagagagt
    16681 cgtaaagaaa gaaaaaccaa tcaaaaattt ttctacggtc aggaaacgaa agtaaaatcc
    16741 aattttttcc ttcaagggaa gaatctagaa gaattaaaag ctaagaaaga agtcaaagcc
    16801 gcaaaagaga atctaaaatc tactaagcaa gcctataagt tcaaaaaaat cagtaggaaa
    16861 gccaaaacct ttctttatgt ccttggacgt gaaggtggag agttagcttc agaaaatgaa
    16921 gatttagaaa gttatcgcac acttcatgag accattagaa aagggaaacg ctacagtcgg
    16981 ctttcttata atcttggaaa agctagtgtc aaaacaggac aagcaacagg tcgttttacc
    17041 aagaaaagac tgaccaacac aaaagagcga taccatcatt ttaaggatgg aaaaggatgg
    17101 aaactaacta aagataatcc aagttccttt aaaaatcggt atcgaaaatt aaagaaacaa
    17161 ggtcttttaa gtgtccgaaa tatctatcaa aaattaaaag gagccttttc cttctttaca
    17221 tttgtggctg gaaatcctgt aatctggata gttggaggaa tagtctttct tcttttactt
    17281 atgatgagct tctttttagg attttcatct gctagtttga ttcaacaaga tgaatttgaa
    17341 ttaacaaaag cttataccca cctaacttgg gaagatgcag aacatactcg tacaaatgac
    17401 aaaggaatta cctattacac aaaagttgat gatgtgatgg gctatatgaa ctttaaattc
    17461 catgactatg agttacagaa accagttcat ttgtttagtt cagaaactta caaggattat
    17521 ctatctgctt tgtggcatga tttaaacgat ggggaagatt tgaaatccat gcaagacctt
    17581 tatgaaactc ctaagtataa actctcgaaa gacgatcaag aggaaataaa ggaactaaaa
    17641 gaagaaggtg tgtatgcttc catgcaggaa ttggacaatc catttgaggg gaaaagtaac
    17701 gaagatagtt tgaccatgac ttatcgttat ggatactatg atttagacgg aaaacctact
    17761 cttcaggagt acattctatt agaagcgaag gctcaccaaa cgattgtcgc accaatggat
    17821 ggagttgtat ctctagatgg agatgatgtt attctcacta acggaaaagg tgagaatgag
    17881 agtcgtttaa ccttatattc cattcataat ggccgtgcga ttgaggggac aagggtctta
    17941 acgggtgatg ttattggtga aacaccagat gatacaggtt tgaaagtttc ctatcaaaag
    18001 tataagaaca agaaagaaaa attggtatat gtcaatccgc aattttattt tccaaaagtc
    18061 attcaacttc agacaactat cttacctgcc attggtcagt ttggtggaga tgagtttgaa
    18121 cgagcaaaac atatttatga ttttttgaaa tctcaagggg caagtcccca agccattgcg
    18181 gctattttag gaaattggtc ggtagagtct tctatcaatc ctaaacgagc tgaaggggat
    18241 tatttatctc ctccagttgg cgctaccgat tcctcatggg atgatgaaac ctggttagcg
    18301 ataggagggc cagccattta tagtggtgct tatcctaata tccttcatag aggtttgggg
    18361 ttaggtcaat ggacggatac cgcagatggt tcaacacgtc atacagcttt gttaaattat
    18421 gcacgcaccc aaaataagaa atggtatgat ttagacctac aacttgattt tatgcttcat
    18481 ggggatagtc cttactatca aagttggtta aaggatttct ttaaaaatac gggcagtgca
    18541 gccaatctcg cccaactctt cctcacctat tgggagggaa attctggtga caaactactg
    18601 gaaagacaaa ccagagcaac ggaatggtat taccaaattg aaaaaggctt cagccaaaca
    18661 aatggaggac aggcaaaaag tgacccgcaa tcccttgaag gtgttcgtgg agacttgtat
    18721 gaacattctg ttcctggtgg tggagatggt atggcctatg cctatggaca atgtacatgg
    18781 ggtgttgcgg ctcgtatgaa tcaattaggc ttaaaattaa aaggaagcaa tggagagaag
    18841 atttcaatca ttaataccat gggaaatggt caggactggg ttgcgacagc ttcaagtctt
    18901 ggtggagaaa cgggttccac accaagagca ggtgctattg tttcttttgt aggaggtaca
    18961 catggtacac cagctatcta cggtcatgtg gcttttgtag agaaggtcta tgatgatggt
    19021 tctttccttg tgtctgaaac taactatggt ggcaacccta actatacctt tagaaaaatc
    19081 tctcatgcag atagtgccat tagttttgcc tatactacga aataaagaag tttacacttg
    19141 caattttagc tattttcagg taaaataaat agtgtagatg agtggtcggc tcatggtcaa
    19201 tctgatagta atcttggacg taagggccaa gcggtggcgg acaccagaac gaaatccgat
    19261 agcaatcttg gacgtaaggg ccaagcggtg gcagacacca gaataaaccg actgactagg
    19321 tggcttacag actctgtaaa ccaccttttt ttgtgaggaa aatatggcaa attctagaga
    19381 ttatcgtaat ccaaattaca ccgaaacaat aaaacttcag cgttttttta cacagttaca
    19441 aattgcggct tcttttttta aagaacactt tgttggcaaa attatgtatt atgaaacgga
    19501 aattgaaagt gttgaacttc atttttcacc tactaatttc atgcacctat gtggtgttga
    19561 ttaccgaaaa ggtgcaggca gtttctttga cgattgttta aatagacatg tcataattga
    19621 tgagttgaaa ataaaaaaag atggaaccac gatgcaaaag ttacaagttt taggatccat
    19681 tggggagtta ttgggaaagc atgttcatct aactggttca ggacgttatt tgtatttgga
    19741 gtttgattat gctctacgta caagaaaaca gataatagca ttaacattga aagagacctc
    19801 taggaaaatt gttcctcaat ctttattaga tttgaagaga aagacagtat ttccaaaagg
    19861 tcaaaaagta atttcaattt actcaaaaca tttacaaaca tcggaacttt tttattattt
    19921 aaaagattag tttacatatc ttttgtggta taaaatatat ttttatcatt ttcaggagaa
    19981 cgcagttttg gctcgttctc tttttttgtt gtgatacttc tttcaaggaa tatttggtag
    20041 gattggagtg aaaaaaaatt aactaggaaa gaaggaagta tatggaagcc atttatcaac
    20101 gtgattcgga tcaagatgga ttaactgatg ctcaagaatt ggccctagga accaatcctc
    20161 ttagctcaga ttctgatggt gatggacgtt cagatttagt ggaaatagaa gaaggaacca
    20221 atcccttaga aaaggattta caagacatag accaaacaag tatcactgaa tcgtcatcag
    20281 tatttatgga aatgaaacaa aagatttcag atatgatgga gagtcactac aaggaattta
    20341 tactggctct gattagtatt gaaacaggga ttgaaaacca acaagaccta gaagacttat
    20401 atacttacta catgagaatg gatgccgttt ctcttttatc tagtgattta gaaaccagtc
    20461 ctcaagaggt tgaaatggag atagagttgt aggggaatca tgtgattctc ctattttcgt
    20521 atagatgaaa ggagcgagta tggaagtaat acaattattg gctatgtttc gtggaacaat
    20581 tccaaaagat agggataaaa tggacctatt tcttcgctat caggcgcaac attttgatga
    20641 gaaatggcag gacttggtag agagtttttt gactgaagag gagaagatag aagagatacc
    20701 tcatgtctat tcgtttcatc aagacattgt ttctttccta gaggccagtt ctgaaaataa
    20761 tgaccaagat ctagaaagtt acacaagaaa ttttggacaa gcaggactag ataaattatc
    20821 tcaattaagt aattttgaga aaaatttggt gctaaaagtc gcaagctata acctttccac
    20881 tcgattttac atccaatctg aaaaagagaa actaacacca ttaagtgagc ttgtatttca
    20941 tcagaatcag gatgttaatt tagtcaatgt ctatcgggtt gcgaataatc tatctgaccg
    21001 tattagtaga gatatagagg aatttcttct aatggttgac tcaaaagagg ttaaaaaaga
    21061 agttcctgag attcattttg aagaaaaaga gggagatgtt ctagcctatt tgggttcaga
    21121 attgatggct actttagata tcgttacgga tcttgtccat catgaagaaa actacataca
    21181 actcccactg acacaaaagc tgaagattat tactcatttt gatgaagtaa aagctaaaag
    21241 cgaaaagtct aatcaagtag agaaaatttt atctccttca agtgatattg aacaggaaac
    21301 ggaagaaact aactcctttt ctaatgtcga taaaattgta gaagaagctt tgagggaata
    21361 tccaatcggt tcacaagtaa gttataaagg acaagtattt cagttggttt cgattgaaaa
    21421 tgcgcagtta aatgacttag ttcgcctaga gctattcaat gattccaacc agttatttga
    21481 agagaatcct atcttatact tgaacagttt ggaagagatt gaacaagtat tgtctcattt
    21541 agaacttgaa aaagaagatt cagagattga gattgattca tcaagtgaaa gtcaggaaat
    21601 agatttgttt tcatacctgg aagaagaaaa tgtaaatgaa aaggataagg ataaggaaac
    21661 aaaatcttta atttcaggta tagaagagac ggatgtccct gttctagatt ttgtttttcc
    21721 agatgattta gaggactttt atcctaagac aaatcgagaa aagattgaaa cgaatatcgc
    21781 cgcaattgaa cttgttaaaa gattagaaaa agagagacga caagcgaatc cagaagaaca
    21841 agagctactc gccaagtatg tcggctgggg cggtcttgcc aatgaatttt tcgatgaact
    21901 caatccaaag tatgaaacag aacgtttaac tcttaagagc ttagtaagta aatcagaata
    21961 ctcgaccata aaacaaagtt ctctcacagc ctattataca gacccaatga ttattcgcca
    22021 gatttggcaa aaattactgg atgatggttt tgagggagga aggatattag atccttctat
    22081 ggggactggg aacttctttg cggcgatgcc tagaagtata cgagagaaat cagaactcta
    22141 tggggttgaa ttagacagtg tgactggtgc aatcgcaaaa caactccacc ccaataccca
    22201 tattgaagtg cgaggatttg aagaagttcc ctatcaaaat aatagttttg atttagtctt
    22261 aacgaatgtt ccttttggaa attttcgcat tgccgataaa aactatgata aaccttatat
    22321 gattcatgat tactttgtca aacactcact tgatttagta agagacggag gacaagtgtc
    22381 gattatctca tctattggga caatggataa gcggacagat aatgtcttac aagagattaa
    22441 atccaatact cattttttag ggggagttcg gttgccggat acggctttta aaaagattgc
    22501 aggtacccga gtgaccacag atctcctatt ctttcaaaag gatcaagcaa agaatcttaa
    22561 tgaggaggaa cttgtcttta gtggctctgt tccctttgag gaggataagc gtgtctggat
    22621 caatccttat tttgatggga aatacaatac acaagttttg ggtgaatatg aggtacgtaa
    22681 ttttaatgga ggaaccctca atgttaaggg ggaatcagaa acattagcta ctgacataat
    22741 gaaagcatta gagaatgtag aagcacctaa acaaattgac aattctttga aagcacctgt
    22801 ttttatccaa gaagaagtgg ataattctat cccaagtcat atacgtgaga acttagcgct
    22861 ctattctttt ggatatgagg gaaatcaaat ttattatcga gatacgcatg gcattcggag
    22921 aagttcaaaa gtagacgaaa ttagttatta tgtagatgag aagggagatt ttaaagcttg
    22981 ggacagttcc ttgtctgaac ataaaataga tcgattcgtg caacttcatt tgacagatga
    23041 ggaagcacta gatgtataca agtcagaaga agcgagtaaa agagggaaat ataagggctt
    23101 gttcaaaaaa acggtctttt atgaaagccc cttatcggat aaggatatta gtcgcattaa
    23161 gggcatggtt gatttgagag agacctatca agccttaatt gaaattcaac gccatccaga
    23221 ttatagtcgg acagattttc aggtattact tagtaaactc aatcgtgact atgatcggtt
    23281 tgtaagccaa tttggatact tgaatgtctc agtcaatcga aacttatttg atagtgacga
    23341 taagtattct ttactagcaa gtttagaaga tgaatacatt gattctaaag atcagaaagt
    23401 aaaatataaa aaatctttag cctttgagaa agcattggtt aggccggaga gagtgattac
    23461 aagagtttca acggctttag atgccttaaa ctccagttta tcagatggta gaggggttga
    23521 tatagacttt atggtatcaa tttaccctga acatagccaa gcagctattt tagatgagtt
    23581 gggtgaccag atcttaatgg atccagaaag ctatttaaga ggggaaagaa attatctttc
    23641 taagaaccag tttttgtcag gagatattct caacaagata gaagtagttc aactattagt
    23701 agaggaaaac aaccaagaat gtgattggac tcatgcgtta gatttgttag aatctgttcg
    23761 ccctccaagg attcatctgg cagatattga gtttaaaata gggtcacgtt ggattcctca
    23821 atccgtttat ggtaaatttg cctttgaatg ttttaccaac cgtgaatttg aattgtcttc
    23881 gcctgatgtt gaacaagtca ttgaagtgaa tcctgtcgat gggcaggttc atttaaggac
    23941 accatttgct tatcgctatc caagtgccaa agatagtagt cttggagtca gtggctcacg
    24001 ttatgataca ggaagaaaga tttttgagaa tttacttaat tcgaaccaac cgactattac
    24061 tatgactgtt acggaagggg aaaagaaaaa gaccatcaca gatttggaaa aaacctctgt
    24121 tctaagagca aaagagcagc atttacaaga actctttcaa gactttgtct cacggtatcc
    24181 agaagttcaa caagtcattg aagaaagtta taatcgtctt tataatcgaa cggttagtcg
    24241 agagtatgac ggtagccatt tagtcattga tggcttggca caaaacatca gtcttcgtcc
    24301 tcatcaagag aatgccattc aaagaattgt agaagaaaaa agagccttgt tagctcatga
    24361 ggtaggttca ggaaagacct tgaccatgct tggtgctggc tttaaattaa aggagttggg
    24421 gatggttcat aagcccttgt atgtggtgcc ctctagtttg tctgctcagt ttggccaaga
    24481 aatcatgaaa tttttcccta ctaaaaaagt ctttgtgacc actaagaaag attttgtgaa
    24541 ggcaagaaga aaacagtttg tgtcacgtat tattacagga gattacgatg ccattgtcat
    24601 tggggattct caatttgaaa aaatccctgt cagtaaggaa agacagatga attatatcga
    24661 ggataaactc aatgaactac gagagattaa aacacattct gaaaataagt acaccgttaa
    24721 agaagcagag caatcaataa gtggtcttga gaaacaattg gaagaactcc aacgctttaa
    24781 tcgtgatagt tttattgatt ttgagaactt aggaattgat tttctctttg tggatgaagc
    24841 acattacttt aaaaatatac gtccaattac tggacttgga aatgtagcag ggattaccaa
    24901 tacaacgtct aagaagaatg tggatatgga aatgaaggtt cgacagattc aggaagaaca
    24961 tgattttaaa aatattgtct ttgcgacagg aacacctgtt tcaaattcaa ttagtgagct
    25021 gtatactatg atgaactaca ttcaaccgga tatcttaaaa cgctatcaag ttgattattt
    25081 tgactcttgg gtaggtgctt ttggagaaat tcaaaactct atggaattag ctcctacagg
    25141 ggataagtac cagcctaaga aacgatttaa aaagtttgtc aatctacctg agttgatgaa
    25201 aatctataaa gaaacagccg acattcaaac acaagatatg ttggatttac ctgtaccaga
    25261 agcccatatt atccctattg agagtgagtt aactgaaaac cagaaactct atctagaaga
    25321 attggttatg agatcagatg cggtcaaatg tggaacagtt gatccaagtc aggataacat
    25381 gttaaaaatt acgggtgagg cacgaaaatt agctattgat atgcgtttat tggactctag
    25441 ttatagtcta gcagacaatc ataaactgct tcaggtagtg gataatgttg aaagaattta
    25501 tcgtgaggga atggaaaata aggctactca gatgattttt tcagatattg gcacacctaa
    25561 gaaaaaagat aatggctttg atgtttattc tgagattaag gctttattag ttgatagagg
    25621 aatccctagt atggaaattg cctttgtaca tgatgccaat agtgatgaaa agaagaatag
    25681 cttgtctcga aaggttaatg caggagaggt tcgggttctt cttgcctcaa ctgaaaaagg
    25741 aggaacaggt ttaaatgttc agagcaagat gaaagcagtt caccatctgg atgtaccgtg
    25801 gagaccaagt gacattcagc gtgcgtccgt aaaggcggta tagtaaatct actcttggca
    25861 aagtagtagg cgtgacctta atgcctatca tcacccaact gacctgtgag ggaaaccaaa
    25921 catcagggaa caaagcacgt tgggaaactc ataagttgat gagttatcac atcacgactg
    25981 aatgaggaga tgataatgta acagatgtta ctgagataat tataaggata aaatctaaac
    26041 tgattgaagg atagtctaaa cggtctgtgt cgggactgtg aggtaagata actaaaatcc
    26101 tcatactatg gaacttcatt atcactgttg aagatagtga agcaaaggga ttccatagcg
    26161 tattcatagt aaatgaaaac agatgaacgt cctatccgat gaaattatca agctatgtta
    26221 ctataccagc taaacggaga ttacctaagt caaaacgctt gtaaaagcta ttaaacataa
    26281 ggtttatgaa tatttgataa ggtaacggag ttcccatagt agtccgagcg tgttaatggc
    26341 acgtacatgg cgaaggggaa cagtttataa cattaacatt atggaaagga aggtgtgtga
    26401 gacaccatga gaaatcctca aaatgtgtta aacaatctaa caaaacacag taaagataaa
    26461 aactatcaat ttgagcgact gtatcgtttg ctttataaca aagaaatgta cttagttgcc
    26521 tatcaaacga tttacgctca cccaggacac ttgacacctg gagtagacga gttgacgatt
    26581 gatggtatga gtatagctag aattgaccaa ttgattgatt ccctgaaaga tgaatcctat
    26641 cagccacacc catcaagacg aacctatatt cctaaaaaga atgggaagct acgtccacta
    26701 ggtattccat catttgatga taagctctta caacaggtta ttaaaatgat tttggaagct
    26761 atctacgagg gacaatttga accctcttcc catggttttc gtccgaataa aagttgccat
    26821 acagcactta ctcagattca gaagacctac actggaacaa aatggtttat tgaaggagat
    26881 atcaagtcat tctttgataa tatcaatcat gatgtgatga ttcacattct ccgagaaaga
    26941 attactgatg agcggttctt acgcttgatt cgtaaattcc tcaatgcggg atacgtggaa
    27001 gattggaaat tctacaaaac ctactcagga actccacaag gagggataat cagtcccatt
    27061 ttagccaata tctatttgga taagtttgat aaatatatga cggattatgt gaagaacttc
    27121 tgccaaggga aataccggaa acgtacccca gaatatcgcc agaatgagat agagttggga
    27181 aaagcaagaa gagcattaga atatgtttca acggaaaatc aacgacaaga agttatccag
    27241 cgtattcgtc aattggaaaa ggaaagagtg ttaattcctc atagtgatcc tatggatagt
    27301 agttttaaac gtctaaccta cacccgatac gcagatgatt ttatctgcgg tgtgattggc
    27361 agtaaagagg acgctcttcg cattaaagca gatattaagg actatttgga ggcagttctc
    27421 aaattggaac tctctgtaga gaaaaccttg attaccaatg cgagagataa agctaagttt
    27481 ctgggatatc atctgtatat tcgccaatcg aatttagcta agcgtgattc ggcaggacga
    27541 ttggtcagaa attatacagg tagattagtc ctagaggttt ctattgaaac gattcgagac
    27601 agattactgt cttacggagc tatgaaaatg acttatcata gaggctacga agtttggaaa
    27661 ccaacggccc gttatttcat gaaagattgc gatgatttag agattctaga acgctacaat
    27721 gcagaaataa gaggttttta taactattat tgtatcgcta ataacagctc tatccttcat
    27781 cgctttaagt acatcatgga atatagcatg tataaaactt atgcgactaa atatcgtacg
    27841 actaaatccc acatcatccg taaatataaa aaggatggtc aatttagggt acagtatatt
    27901 ggacgtaaag gggatacaat gacccgctat ttctataacg gaggatttaa acgtcaaaag
    27961 aaatctttcc ttgacaatga taatttgcca aatacggcga aatattttag tcgaacaaat
    28021 ttaattgata gattaaaagc aagccgttgt gagtattgtc aagcgaccga cagttcccta
    28081 gaaatccatc atgtgagaaa actaaaggat ttaaagggaa agactttttg ggaacgtttg
    28141 atgatttcta gacaacggaa aacaatagca ctgtgtaaag attgccataa gaaattacat
    28201 catggcaagt tagattgagt ttataaacgg agagccgtat acattgaaag gtgtacgtac
    28261 ggttcggggg cgagtatttg gaaacctgcc gtagtaatat ggtaaggcgc tgggtactta
    28321 gcctacaacg taatggacgt attatccgac agggaaatga aaacaaggaa gtggatattt
    28381 accactatat taccaaaggt tcgtttgata attatctatg ggcaactcag gagaacaaac
    28441 tccgttatat taagcagatt atgacttcta aggagccgat tcgtgctgcg gaagatattg
    28501 atgaacagac tatgacagct tctgatttta aggcactagc aacaggtaat ccttatctca
    28561 aatataagat ggaactagag aatgatctaa ctctattaga aaatcaaaga cgcgcctttc
    28621 aacgcagcaa ggatcactat cgtcatacaa tctcttactg tgaagaaaat atgcccattc
    28681 ttgagaaacg attaagcaag tatgaaggcg acattcaaca gtctgaaatg tcgaaagacc
    28741 aatcattttc tatgacgata ggtaaacaag tttttgagca acgagctgaa gcaggtgaat
    28801 ccctacaccg tcttatccgt cataatcaat ctgacagcaa agaatttcga accctagcaa
    28861 gttatcgagg atttgacatt aaaatgctta gtcttgcaac aaatcaacct cttcctgaaa
    28921 ccttctctgt taagattgta ggagaaaacc aatattctgt cagtttagat ttgtattctc
    28981 ctttggggac aattcaaagg cttcagcata cgatagacca cattaaagat gaccaagtga
    29041 aaactcagaa cttattggat gaattaaagg ataaatggac tactgctaag gtagaaattg
    29101 agaaaaattt tccaaaggaa gaggattatc aaactaaaaa ggccgaatac gatgtactcg
    29161 cgccattgat tgaaacagaa acggatttag atattattga tcaggcctta cgacaattcc
    29221 acgaaaaagg aaaagaaaag caagaacaac tttcttttga attagattaa aaaatagata
    29281 taaatagcgg acaagaaaag aaaagcgcgg tagaataaag atagaaagaa acgaggtaac
    29341 gattatgatg gaagatacct attatcaatt agaagaggct ttggtacagg gatttcaaac
    29401 acctgaagaa taccaagcct acaaggagtt aaaggaacat tatgaggaag tgacagggga
    29461 ttacagtttt tctaaacgag agctcactag tcaattggaa atcgctcttc agaatcatca
    29521 aggtgtggac tttgaagaac atgaaaaaga agagtatttg gacttagttc aaaaattaga
    29581 agagtttgat tcctctcttg ccacccatta tcgtcagttg attgattaga aaggagaaag
    29641 tcatgaatga tttactcctt atcccagtaa tttttttagc agtaggagga attatcattc
    29701 ttttatggag actctttctt attgccagtg gacttttcct tattggtttt gtcagttttc
    29761 ttattttcgt agaggtctat ggaatttatc tgttctttac tgaacctagt ttatattttg
    29821 atgatatcag acaatatggt ttaactagtt ttacggctgt gtaccttttc atcaatctga
    29881 tgttggttct aggatttagt tggcgcttca ttaactccat aaataagcat aaaatgtgaa
    29941 ctttttagat agttaaaaga ctttattcaa aggtaagttt gaataaagtc tttttgttga
    30001 tgtgcttata atcccgtctt agtacttagt gtgagaaaca aaaagagatg aattaaaatt
    30061 aaagtgtaca gaatgcttaa gagtttctat ttttcttata atatatagta atttcggtac
    30121 aaattaa
//
LOCUS       DBERMM010000022        28282 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.022, whole genome shotgun sequence.
ACCESSION   DBERMM010000022 DBERMM010000000
VERSION     DBERMM010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 28282)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 28282)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..28282
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.022"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(18..1976)
                     /gene="ftsH"
                     /locus_tag="ACL8AS_001247"
     CDS             complement(18..1976)
                     /gene="ftsH"
                     /locus_tag="ACL8AS_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HGS1229105.1"
                     /translation="MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYT
                     ELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTI
                     LPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGG
                     GNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGAR
                     IPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAK
                     KAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNR
                     SDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFV
                     GADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHE
                     AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGR
                     VAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMLGAQSPQKS
                     ISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYE
                     TGKMPEAVEEESHALSYDEVKSKMNDEK"
     gene            complement(1992..2534)
                     /gene="hpt"
                     /locus_tag="ACL8AS_001248"
     CDS             complement(1992..2534)
                     /gene="hpt"
                     /locus_tag="ACL8AS_001248"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006166 - purine ribonucleoside salvage
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HGS1229106.1"
                     /translation="MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKG
                     SIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDII
                     DTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
                     KENYRNLPYIGVLKEEVYSN"
     gene            complement(2538..3815)
                     /gene="tilS"
                     /locus_tag="ACL8AS_001249"
     CDS             complement(2538..3815)
                     /gene="tilS"
                     /locus_tag="ACL8AS_001249"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016879 - ligase activity, forming
                     carbon-nitrogen bonds [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HGS1229107.1"
                     /translation="MREQDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQK
                     ELEIELILAHVNHKQRIESDWEEKELRKLAAEAELPIYISNFSGEFSEARARNFRYDF
                     FQEVMKKTGATALVTAHHADDQVETILMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL
                     HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPELEKENPRFRDAILGIGNEILDYD
                     LAIAELSNNIDVENLQQLFSYSESTQRVLLQTYLNRFPDLNLTKAQFAEVQQILKSKS
                     QYRHPIKNGYELIKEYQQFQICKISPQADEKEDELVLHYQNQVAYQGYLFSFGLPLEG
                     ELIQQIPVSRETSIHIRHRKTGDVLIQNGHRKKLRRLFIDLKIPMEKRNSALIIEQFG
                     EIVSILGIATNNLSKKTKNDIMNTVLYIEKIDR"
     gene            complement(3812..5080)
                     /locus_tag="ACL8AS_001250"
     CDS             complement(3812..5080)
                     /locus_tag="ACL8AS_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /protein_id="HGS1229108.1"
                     /translation="MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIY
                     FREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQITEWRLNKQGIPVFKLSNHQFI
                     AADKRFLYDQSEVTPTIKKVWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEG
                     REFLHIDQAGWVAKESTSEEDNRMSKAQEMLSEKYQKDSFSIYVKQLTTGKEAGINQD
                     EKMYAASVLKLSYLYYTQEKINEGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKED
                     NKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSAIMGDDWDPKEKLISS
                     KMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYA
                     DSPFILSIFTKNSDYDTISKIAKDVYEVLK"
     gene            complement(5073..5195)
                     /locus_tag="ACL8AS_001251"
     CDS             complement(5073..5195)
                     /locus_tag="ACL8AS_001251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0009 family protein"
                     /protein_id="HGS1229109.1"
                     /translation="MENLLDVIEQFLSLSDEKLEELADKNQLLRLQEEKERKNA"
     gene            complement(5200..5568)
                     /locus_tag="ACL8AS_001252"
     CDS             complement(5200..5568)
                     /locus_tag="ACL8AS_001252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HGS1229110.1"
                     /translation="MSKNIVQLNNSFIQNEYQRRRYLMKERQKRNRFMGGVLILIMLL
                     FILPTFNLAQSYQQLLQRRQQLADLQTQYQTLSDEKDKETAFATKLKDEDYAAKYTRA
                     KYYYSKSREKVYTIPDLLQR"
     gene            complement(5561..5827)
                     /locus_tag="ACL8AS_001253"
     CDS             complement(5561..5827)
                     /locus_tag="ACL8AS_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001234972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HGS1229111.1"
                     /translation="MRLDKYLKVSRIIKRRTVAKEVADKGRIKVNGILAKSSTDLKVN
                     DQVEIRFGNKLLLVKVLEMKDSTKKEDAAGMYEIISETRVEENV"
     gene            complement(5885..9394)
                     /gene="mfd"
                     /locus_tag="ACL8AS_001254"
     CDS             complement(5885..9394)
                     /gene="mfd"
                     /locus_tag="ACL8AS_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000258090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003684 - damaged DNA binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HGS1229112.1"
                     /translation="MVTLLDLFSENDQIKKWHQNLTDKKRQLILGLSTSTKALAIASS
                     LEKEDRIVLLTSTYGEAEGLVSDLISILGEELVYPFLVDDAPMVEFLMSSQEKIISRV
                     EALRFLTDSSKKGILVCNIAASRLILPSPNAFKDSIVKISVGEEYDQHAFIHQLKENG
                     YRKVTQVQTQGEFSLRGDILDIFEMSQLEPCRIEFFGDEIDGIRSFEVETQLSKENKI
                     ELTIFPASDMLLREKDYQRGQSALEKQISKTLSPILKSYLEEILSSFHQKQSHADSRK
                     FLSLCYDKTWTVFDYIEKDTPIFFDDYQKLMNQYEVFERELAQYFTEELQNSKAFSDM
                     QYFSDIEQIYKKQSPVTFFSNLQKGLGNLKFDKIYQFNQYPMQEFFNQFSFLKEEIER
                     YKKMDYTIILQSSNSMGSKTLEDMLEEYQIKLDSRDKTSICKESVNLIEGNLRHGFHF
                     VDEKILLITEHEIFQKKLKRRFRRQHVSNAERLKDYNELEKGDYVVHHIHGIGQYLGI
                     ETIEIKGIHRDYVSVQYQNGDQISIPVEQIHLLSKYISSDGKAPKLNKLNDGHFKKAK
                     QKVKNQVEDIADDLIKLYSERSQLKGFAFSADDDDQDAFDDAFPYVETDDQLRSIEEI
                     KRDMQASQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVILVPTTVLAQQHYTNFK
                     ERFQNFAVNVDVLSRFRSKKEQTATLEKLKNGQVDILIGTHRVLSKDVVFADLGLMII
                     DEEQRFGVKHKETLKELKKQVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPV
                     QTYVLEKNDSVIRDAVLREMERGGQVYYLYNKVDTIVQKVSELQELIPEASIGYVHGR
                     MSEVQLENTLLDFIEGQYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRGR
                     VGRSNRIAYAYLMYRPEKSISEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNLLG
                     KSQSGFIDSVGFELYSQLLEEAIAKRNGNANANTRTKGNAELVLQIDAYLPDTYISDQ
                     RHKIEIYKKIRQIDNRVNYEELQEELIDRFGEYPDVVAYLLEIGLVKSYLDKVFVQRV
                     ERKDNKITIQFEKVTQRLFLAQDYFKALSVTNLKAGIAENKGLMELVFDVQNKKDYEI
                     LEGLLIFGESLLEIKESKEENSI"
     gene            complement(9395..9964)
                     /gene="pth"
                     /locus_tag="ACL8AS_001255"
     CDS             complement(9395..9964)
                     /gene="pth"
                     /locus_tag="ACL8AS_001255"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HGS1229113.1"
                     /translation="MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIF
                     QADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKI
                     RLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
                     LQSVDKVDDSVNYYLQEKNFEKTMQRYNG"
     gene            complement(10035..11150)
                     /gene="ychF"
                     /locus_tag="ACL8AS_001256"
     CDS             complement(10035..11150)
                     /gene="ychF"
                     /locus_tag="ACL8AS_001256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HGS1229114.1"
                     /translation="MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMV
                     EVPDERLQKLTEMITPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREVDAIVH
                     VVRAFDDENVMREQGREDAFVDPLADIDTINLELILADLESVNKRYARVEKMARTQKD
                     KESVAEFNVLQKIKPVLEDGKSARTIEFTDEEQKVVKGLFLLTTKPVLYVANVDEDVV
                     SEPDSIDYVKQIREFAATENAEVVVISARAEEEISELDDEDKKEFLEAIGLTESGVDK
                     LTRAAYHLLGLGTYFTAGEKEVRAWTFKRGMKATQAAGIIHSDFEKGFIRAVTMSYED
                     LVKYGSEKAVKEAGRLREEGKEYIVQDGDIMEFRFNV"
     gene            complement(11234..11428)
                     /locus_tag="ACL8AS_001257"
     CDS             complement(11234..11428)
                     /locus_tag="ACL8AS_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 family protein"
                     /protein_id="HGS1229115.1"
                     /translation="MYQVGNFVEMKKSHACTIKSTGKKANRWEITRVGADIKIKCSNC
                     EHVVMMGRYDFERKMNKIID"
     gene            complement(11493..12629)
                     /gene="dnaN"
                     /locus_tag="ACL8AS_001258"
     CDS             complement(11493..12629)
                     /gene="dnaN"
                     /locus_tag="ACL8AS_001258"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009360 - DNA polymerase III complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HGS1229116.1"
                     /translation="MIHFSINKNLFLQALNTTKRAISSKNAIPILSTVKIDVTNEGIT
                     LIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQN
                     QIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRP
                     ILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDD
                     IETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSME
                     RARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYL
                     IDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN"
     gene            complement(12788..14149)
                     /gene="dnaA"
                     /locus_tag="ACL8AS_001259"
     CDS             complement(12788..14149)
                     /gene="dnaA"
                     /locus_tag="ACL8AS_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003688 - DNA replication origin binding
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA];
                     GO_process: GO:0006275 - regulation of DNA replication
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HGS1229117.1"
                     /translation="MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFL
                     PRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYNYS
                     PKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLG
                     KTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLID
                     DIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQ
                     TITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVK
                     KIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVL
                     ARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKK
                     KIK"
     gene            complement(14362..15120)
                     /locus_tag="ACL8AS_001260"
     CDS             complement(14362..15120)
                     /locus_tag="ACL8AS_001260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HGS1229118.1"
                     /translation="MEKFEMISITDIQKNPYQPRKEFDREKLDELAQSIKENGVIQPI
                     IVRQSPVIGYEILAGERRYRASLLAGLRSIPAVVKQISDQEMMVQSIIENLQRENLNP
                     IEEARAYESLVEKGFTHAEIADKMGKSRPYISNSIRLLSLPEQILSEVENGKLSQAHA
                     RSLVGLNKEQQDYFFQRIIEEDISVRKLEALLTEKKQKKQQKTNHFIQNEEKQLRKLL
                     GLDVEIKLSKKDSGKIIISFSNQEEYSRIINSLK"
     gene            complement(15178..16359)
                     /locus_tag="ACL8AS_001261"
     CDS             complement(15178..16359)
                     /locus_tag="ACL8AS_001261"
                     /EC_number="3.4.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S1C family serine protease"
                     /protein_id="HGS1229119.1"
                     /translation="MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNS
                     NNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSE
                     GSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
                     EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAI
                     STKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINI
                     IEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHL
                     EKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLE
                     S"
     gene            16542..17021
                     /gene="rlmH"
                     /locus_tag="ACL8AS_001262"
     CDS             16542..17021
                     /gene="rlmH"
                     /locus_tag="ACL8AS_001262"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HGS1229120.1"
                     /translation="MKIKVVTVGKLKEKYLKDGIAEYSKRISRFAKFEMIELSDEKTP
                     DKASESENQKILEIEGQRILSKIADRDFVIVLAIEGKTFFSEEFSKQLEETSIKGFST
                     LTFIIGGSLGLSSSVKNRANLSVSFGRLTLPHQLMRLVLVEQIYRAFTIQQGFPYHK"
     gene            17065..17138
                     /locus_tag="ACL8AS_001263"
     tRNA            17065..17138
                     /locus_tag="ACL8AS_001263"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:17099..17101,aa:Arg,seq:tct)
     gene            17303..17428
                     /gene="comC"
                     /locus_tag="ACL8AS_001264"
     CDS             17303..17428
                     /gene="comC"
                     /locus_tag="ACL8AS_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence-stimulating peptide ComC"
                     /protein_id="HGS1229121.1"
                     /translation="MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK"
     gene            17449..18774
                     /gene="comD"
                     /locus_tag="ACL8AS_001265"
     CDS             17449..18774
                     /gene="comD"
                     /locus_tag="ACL8AS_001265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000362880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence system sensor histidine kinase ComD"
                     /protein_id="HGS1229122.1"
                     /translation="MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTE
                     IVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQYERDRGLFLSLLLSLLYESTHNF
                     LSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
                     VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIA
                     LKQKKFEQKHLQNYTDEIVGLYNEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEV
                     LVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEFTLEVKDTITKLPIE
                     LLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFA
                     LGFSTKGRNRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE"
     gene            18771..19523
                     /gene="comE"
                     /locus_tag="ACL8AS_001266"
     CDS             18771..19523
                     /gene="comE"
                     /locus_tag="ACL8AS_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence system response regulator
                     transcription factor ComE"
                     /protein_id="HGS1229123.1"
                     /translation="MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEE
                     YIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNPYAIIVFITSRSEFATLTYKYQV
                     SALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
                     IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRK
                     NLEIVFYEDHRCPISRLKIRKLKDILEKKSQK"
     gene            19575..19646
                     /locus_tag="ACL8AS_001267"
     tRNA            19575..19646
                     /locus_tag="ACL8AS_001267"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:19608..19610,aa:Glu,seq:ttc)
     gene            19652..19725
                     /locus_tag="ACL8AS_001268"
     tRNA            19652..19725
                     /locus_tag="ACL8AS_001268"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:19686..19688,aa:Asn,seq:gtt)
     gene            complement(19766..20308)
                     /locus_tag="ACL8AS_001269"
     CDS             complement(19766..20308)
                     /locus_tag="ACL8AS_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HGS1229124.1"
                     /translation="MQESNKRLKTKRTIENAMVQLLMEQPFDKISTVKLVEKAGISRS
                     SFYTHYKDKYDMIEHYQSKLFHTFEYIFQKHAHHKRDAILEVFEYLESEPLLAALLSE
                     NGTKEIQNFLRNKLHIMLSTDLQKRFMQLNLNTTELEYSSIYLTHALFGVCQTWIAHG
                     KKESSQEITDFLMKMLGDTN"
     gene            20487..22090
                     /locus_tag="ACL8AS_001270"
                     /pseudo
     CDS             20487..22090
                     /locus_tag="ACL8AS_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518194.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip family protein"
     gene            complement(22120..24672)
                     /locus_tag="ACL8AS_001271"
     CDS             complement(22120..24672)
                     /locus_tag="ACL8AS_001271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HGS1229125.1"
                     /translation="MKSFLKTYRTYFISFIIPVVIMSGVYLSQGIYWNSDNSPLLGDG
                     FHQYVIFDVALRNILHGNSSLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMP
                     DAVYLTTLLKFGLIGLSTFFSLNKLFQSIPQTLKLALSTSYALMSFTVSQLEIKTWLD
                     VFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDF
                     KTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAK
                     QFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIE
                     ALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFL
                     ATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSL
                     NASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNY
                     NGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDK
                     YGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDY
                     FSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQK
                     KVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTK
                     TFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQ
                     AQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA"
     gene            complement(24734..26356)
                     /locus_tag="ACL8AS_001272"
     CDS             complement(24734..26356)
                     /locus_tag="ACL8AS_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1229126.1"
                     /translation="MLTVSDVSLRFSDRKLFDDVNIKFTEGNTYGLIGANGAGKSTFL
                     KILAGDIEPTTGHISLGPDERLSVLRQNHFDYEDERAIDVVIMGNEKLYSIMKEKDAI
                     YMKEDFSDEDGVRAAELEGEFAELGGWEAESEASQLLQNLNIPEELHYQNMSELANGE
                     KVKVLLAKALFGKPDVLLLDEPTNGLDIQSITWLEDFLIDFDNTVIVVSHDRHFLNKV
                     CTHMADLDFGKIKLYVGNYDFWKESSELAAKLLADRNAKAEEKIKQLQEFVARFSANA
                     SKSRQATSRKKMLDKIELEEIVPSSRKYPFINFKAEREIGNDLLTVENLTVKIDGETI
                     LDNISFILRPDDKTALIGQNDIQTTALIRAIMGDIDYEGTVKWGVTTSQSYLPKDNSA
                     DFAGGESILDWLRQFASKEEDDNTFLRGFLGRMLFSGDEVNKPVNVLSGGEKVRVMLS
                     KLMLLKSNVLVLDDPTNHLDLESISSLNDGLKNFKESIIFASHDHEFIQTLANHIIVL
                     SKNGVIDRIDETYDEFLENAEVQAKVKELWKD"
     gene            26562..27587
                     /gene="trpS"
                     /locus_tag="ACL8AS_001273"
     CDS             26562..27587
                     /gene="trpS"
                     /locus_tag="ACL8AS_001273"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004830 - tryptophan-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HGS1229127.1"
                     /translation="MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLA
                     DQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLV
                     SLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIE
                     QTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDAD
                     TLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLG
                     DVKTKRYLLEILERELGPIRERRIEFAKDMGEVYNMIQKGSERAREVAGQTLSEVKGA
                     MGLHYFN"
     gene            27739..>28282
                     /locus_tag="ACL8AS_001274"
     CDS             27739..>28282
                     /locus_tag="ACL8AS_001274"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HGS1229128.1"
                     /translation="MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTL
                     NIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPF
                     FLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
                     SENLVTAPVGTDLATAESILQ"
BASE COUNT         8877 a         5073 c         4801 g         9531 t
ORIGIN      
        1 tccagcctct ctcagggtta tttttcgtca ttcatttttg actttacttc atcataggat
       61 agtgcatgag attcctcttc tactgcttca ggcatctttc ctgtttcgta aagagcttta
      121 atttgtgtac tatccaatgt ttcgtatttc aataatgctt ctgcaattaa cttgtgagtt
      181 tcacgatttg actgaataat ttcagcagct ttatttcgtg cctcatttaa taatgaacga
      241 acctcttcat caatttcata agctgtttgt tctgaaattg atttttgagg actctgtgca
      301 ccaagcatag catggtttcc ttcatattgt actgggccaa gtttttcact cataccgtac
      361 tctgtaacca ttgcacgtgc catttgtgtc gcttgttcaa agtcgtttga agctcctgta
      421 gtttggacat taaagataat ttcttcagct acacgtccac ccattaagcc agccaattgc
      481 tctttcatat cttctttaga tagaagcatt tgatcctctt taggaagtgc aatcatgtat
      541 ccgcctgcac ggccgcgtgg tacaattgta accttatgga caacgcgagc attcgacaag
      601 actagaccaa caatggtatg tcctgcctca tggtaagcaa ccaattctcg ttctttttgt
      661 gaaactgtct tatctttctt agaaggtcca gcaataactc tatcttctgc ttcatcaata
      721 tctgaagcat caattatcga tttattgcga cgagcagcaa ctaaagctgc ttcattcaag
      781 acattctcta aatcagcacc aacaaagcct ggagtttgtt gagccactaa tttcaaatca
      841 acatcttctg ctaaaggctt gttcttagcg tgaactttca agattgcttc acgaccttta
      901 acatcaggac ggccaaccaa tacttttcta tcaaaacgtc ctggacgcaa aagggcagga
      961 tcaagtacat ctgaacggtt tgtcgcagcg atgacgataa tcccttcatt tccctcaaaa
     1021 ccatccatct caatcaaaag ttggttcaag gtttgttcac gttcgtcatt acctccgccg
     1081 agaccgactc cacgttgacg tccaacagca tcaatttcat cgataaagat gatagctggt
     1141 gctgcttttt tggcatcctc aaaaagagag cgaacacgac tagctccaac tccgacaaac
     1201 atttctacaa agtcagaacc tgagatacta aagaatggaa cacctgcttc tccagcgact
     1261 gccttagcaa gcaaagtctt acctgtcccc ggaggtccct ccaaaagaac acctgctgga
     1321 atacgggctc caagttttgt gaatcgtttt ggatctttta agaactcaac aacttcaact
     1381 agttcttgtt tttcttcctc agctccagca acatctgaaa atcttacttt aatatcttct
     1441 ttatttgctg ctttagcctt actacgtcca aaactcattg gattacggcc attgcctcct
     1501 cccatatttc ccatcataga gaataggaag aagaatagaa ttccaaatgg cacaatggat
     1561 acgagtagat taatccatat accacttgaa ctttcatgct taacagttac ttctgcttta
     1621 tggtcagtag caagtttttg caattctgat acggtagtat ctgcaggaag aatagtgctg
     1681 gtaaatttct ctaccttagt aacagatggc gtgaaaaact gaatacctgt tccttcttta
     1741 cttgttttag gatttttata gacaccagaa acttcgataa cactaccatt tggttggtaa
     1801 gttaattctt ttacattacc atcggtaatt tcttgtacca actcagtata gttgatttgc
     1861 tgacttcctc ctgagttatt cccagaatag aaatactgga atcctgtcac aaggaaaaag
     1921 ataaataata accatagaaa aggattttta attaaaccat tattttgttt tttcattaaa
     1981 gattattctt tctaatttga atacacttcc tctttcaata ctccaatata aggaagatta
     2041 cgataatttt ctttgtagtc taaaccataa cctactacaa actcatttgg gatagtaaag
     2101 caggtatagt ctgcctcaat ttctacaaca cgtccttctg gtttatccaa caaggttgca
     2161 attttaacag aagctgcttc tctttcttta aacatatctc gcaaattctt caaagtttga
     2221 cctgtatcaa tgatatcttc tacaaataga acatgtcttc ctttgatatc ttgagtcaca
     2281 tcttgtttaa tattgataac accactactt gctgttccac catggtagct agaaaccatc
     2341 atgaagtcca tttcaatatg tgtatcaata tgtttgacca attcagccat aaaaggaata
     2401 gatcctttta aaatcccaac taagattgga ttttttcctg catagtcttt agttaattga
     2461 gcacctagtt ttttagctgc ttctgtaatt tcatcgtgtg aaacgaggac ttttttaata
     2521 tcgttttcta acatttttta cctatctatt ttttctatat aaagtacagt gttcattata
     2581 tcatttttcg tttttttact caaattattg gtcgcaattc ccaaaattga gacaatttca
     2641 ccaaattgct caataataag agcagagttt ctcttttcca tagggatttt caaatcaata
     2701 aataaacgtc tgagtttttt tctatgccca ttttgaatca aaacatctcc tgtttttcga
     2761 tgacgaatgt gtatggatgt ttcacgtgaa acaggtattt gttgaattaa ttcaccttct
     2821 aatggaagtc caaaagaaaa taaatatcct tgataagcta cctgattttg atagtgtaac
     2881 acaagttcat cttccttttc atcagcctgc ggactgattt tacaaatctg aaactgttgg
     2941 tactctttta tcaattcata gccattttta atcggatgac gatactggct tttagatttt
     3001 aaaatctgct gaacttcagc aaactgagct tttgtaagat tcaaatctgg aaaacgattc
     3061 agataagttt gaagtaaaac tctttgtgta gactcagagt aagaaaataa ctgctgtaaa
     3121 ttttccacat caatattgtt agataattca gctattgcca aatcataatc taaaatttca
     3181 ttgccgatgc ctaagattgc atccctaaat cgaggatttt ctttttccaa ttctggtaag
     3241 taagagtttc gaatacgatt tcgaaaataa tgattctcct gatttgatgt atcttcaaag
     3301 tgaaaaattg atggaaagtc ttttttctga aaatgcaaga agggacgaat gatttctatc
     3361 tctccgacta cttgcttctc cttaattcct gatagatagc gcaagcgagt tcctcgaatc
     3421 aagcgcatca aaatcgtttc cacctgatca tcagcatggt gggcagtgac taaagctgtc
     3481 gcacctgtct ttttcatgac ctcttgaaaa aaatcataac gaaaatttcg tgcacgcgct
     3541 tctgaaaatt ctcctgaaaa attgctgata taaataggaa gttctgcttc agcagccaac
     3601 ttccttaatt ccttttcttc ccaatctgat tcaattctct gcttatgatt cacatgagcc
     3661 agaatcaatt caatctctaa ctctttttga taagtagaca ataccttaaa tagaaacata
     3721 gaatctaatc caccagaaag agctagaacc gccttagcat gctttttgaa atatcccttc
     3781 ttgagaaaat gatttaaaaa atcttgttcc ctcattttag aacctcataa acatccttgg
     3841 ctatcttaga aatcgtatca taatcagaat tcttagtgaa aatagaaaga ataaatggag
     3901 aatctgcata gacaacaccc gtatcatgct taaattcatc cgcatctcca attttatgag
     3961 ctactttaac agaaacacct ttggcaattc gctgactatc aaaatctgtt ttagtcaaag
     4021 actctagcac aaatccattt tgattataaa tagcttccat aaacttcccg gccatcttag
     4081 aagaaatcaa tttttctttt ggatcccaat catctcccat aatggcagac attttggatt
     4141 tgaatgtggc atcagattgg tttgaaatgt aatatcccaa tagattatga gctacattat
     4201 cagattcttt tgatactttc gtaattaaat cctttaaaga atattcttta ttatcttctt
     4261 ttttaggaag actaccactt ccctctggtt tataagaacc tggaaaatca ttgactgcag
     4321 atacgtattt tacagtcgta tctaactgat aaagaccctc atttattttt tcttgcgtat
     4381 aatagagata ggagagtttc aaaacgctgg ctgcatacat cttttcatct tgattgatac
     4441 cagcttcttt tccagtagtc agttgcttaa cataaataga gaaagaatct ttctgatatt
     4501 tttcagataa catttcttga gctttactca tccgattatc ttcttcagaa gttgattctt
     4561 tagctaccca tccagcctga tcaatatgta gaaattctct tccttctaca aacatggtct
     4621 tatcgattga tacttgcgaa taagctgata aggatgattt cacttctttt aaatcataag
     4681 gactattgta cagtttaaag tcagattcta accatacttt ttttattgtt ggagttacct
     4741 ctgattgatc atataaaaat cgtttgtccg cagctataaa ttgatgattt gatagcttaa
     4801 atactggaat tccttgttta tttaagcgcc actcggttat ttgaaaactt gttttgggag
     4861 tcaatttccc agattccact actaaatctt cattcgcata aacaggaacc tctccataaa
     4921 ccatgggaga acttaatttt tctctaaaat aaataccaaa gtcagattgt gaaaggtaat
     4981 aaatttcttt cgaagtatag acgacttctt tttctgtgct aacgactttt gaaatggtca
     5041 aaaaacttgg tagcaacaaa ataattaaga atttacgcat tcttcctttc cttttcttct
     5101 tgtaaacgca ataattgatt tttatcagcc aattcttcca gcttttcatc tgacaaactc
     5161 aaaaattgct ctattacgtc taataaattt tccattttat cacctttgaa gcaagtcagg
     5221 aatcgtataa actttttccc tcgacttaga ataatagtac ttcgctcgtg tatatttagc
     5281 agcataatct tcatctttca acttggtagc aaatgctgtt tccttatcct tttcatcact
     5341 caaagtttga tactgagttt gcaagtctgc taattgctga cgtctttgga gtaattgctg
     5401 ataactctgc gctaaattaa aagttggcaa gataaataat agcataatca aaatcaatac
     5461 cccccccata aaacgattcc gtttttgtcg ttctttcatc aggtagcgac gacgttggta
     5521 ttcattttga ataaaagaat tattcaattg tacaatattt ttagacattt tcttctaccc
     5581 gtgtttcact gataatttca tacatgcctg ctgcatcttc tttttttgta ctatctttca
     5641 tctctagtac ttttacaagc agcaacttat tgccaaagcg aatttcaact tggtcattaa
     5701 ctttcaagtc cgttgaactt ttggccaaga ttccattaac cttgattcta cctttatctg
     5761 ctacttcctt tgcgactgta cgacgcttga taattcgcga tacttttaaa tatttatcta
     5821 atctcatcct tattacctca atttattatt gtaccatttt tatctatttt atagaagaaa
     5881 aatatcaaat ggaattttct tccttagact cttttatctc taataaactt tctccaaaaa
     5941 tcagcagacc ttctaaaatt tcataatctt tcttattttg gacatcaaat acaagctcca
     6001 ttaatccctt attctcagcg atgcctgctt ttaagttcgt tacggataaa gctttaaaat
     6061 aatcttgagc taaaaacagt cgttgagtga ctttttcaaa ttgaattgta attttattat
     6121 cttttctttc cacacgttga acaaagacct tgtccaagta tgatttaacc aaaccaatct
     6181 ctaaaagata ggctactaca tctgggtatt ctccaaaacg gtctatcaac tcctcttgta
     6241 actcttcata attgacacgg ttgtcaattt gacgaatttt cttgtaaatt tcaatcttat
     6301 gtcgttgatc agaaatataa gtatcaggaa gataggcatc aatttgcaaa accaactcag
     6361 cattcccttt ggttcttgtg ttagcgttag cattaccgtt tcgtttagca atagcttcct
     6421 ctaataactg cgaatacaat tcaaaaccaa cagaatcaat gaaaccagac tgggattttc
     6481 ctaaaagatt tcctgctcca cgaatcgaaa gatctcgcat tgcaatctta aagccagagc
     6541 ccaattctgt aaatccttta atcgcttcta atctcttttc agagacttca ctgattgatt
     6601 tttctggacg atacatgaga taagcataag caatacgatt actacgaccg actcttcctc
     6661 ttaactgata taaggttgac aagcccatat ggtccgcatt ttcaataaat aaagtattag
     6721 catttggaat gtccacccct gtctcaataa tagtagtcgt caccaagata tcgtattgtc
     6781 cctcaataaa gtctaataga gtattttcca actggacttc actcattcga ccatgaacat
     6841 atccaatcga agcctccgga atcaactcct gtaattctga aaccttctga acaattgtgt
     6901 caactttgtt gtaaagatag taaacttgac ctccacgctc catttcacgc aagacagcat
     6961 cacgaatgac actatcattc ttttccaaaa cataggtctg aacaggatag cgattagtcg
     7021 gcggagtttc aataacagac aaatctctga ttcccagcat agacatatgg agggtacgag
     7081 ggattggcgt agcggtcaag gttaggacat ccacttgttt cttcagttct ttcaaagttt
     7141 ccttatgctt gacaccaaat cgctgttcct catcaataat catcaagccc aaatcagcaa
     7201 acacaacatc ttttgacaaa acacgatgtg ttccaatcaa aatatcgact tgaccgtttt
     7261 tcaatttttc aagtgttgca gtctgctctt ttttacttct aaagcgactc aacacatcaa
     7321 cattaactgc aaaattttgg aatcgttcct taaaattcgt atagtgctgt tgcgctaaaa
     7381 ccgtcgtcgg aactagaatg acaacctgtt tgtgatcatt gactgcttta aaggctgcac
     7441 gcatagcaac ttcagtcttt ccaaaaccaa catccccaac taaaagtcgg tccattggct
     7501 gagaagcctg catatccctc ttgatttcct caatactacg aagttgatca tccgtttcaa
     7561 cataagggaa agcatcatca aaggcatctt gatcatcatc atcagctgag aaagcaaaac
     7621 ccttcaactg actacgttca gagtagagtt tgattaaatc atcagctata tcctctacct
     7681 ggttcttaac cttttgcttg gcctttttaa aatgaccgtc atttaattta ttgagttttg
     7741 gagctttacc atcacttgaa atatatttgg acagtagatg aatctgttcc acggggatag
     7801 aaatttgatc accattttgg tattggacac tgacataatc gcgatgaatt cccttgattt
     7861 caatggtttc aattcctaga tattgaccaa tcccatggat atgatggaca acatagtccc
     7921 ctttttcaag ctcattgtaa tcttttaatc tctctgcatt tgaaacatgt tgtcttcgaa
     7981 aacgacgctt taatttcttt tgaaaaatct catgttcagt tatcaataaa atcttttcat
     8041 ctacaaaatg aaaaccatgt ctgagattac cctctattaa gtttacagat tctttacaga
     8101 tacttgtctt atctctagaa tccaatttaa tctgatattc ctctaacata tcctccaatg
     8161 ttttacttcc cattgaattg ctagactgca gaataatggt gtaatccatt tttttatatc
     8221 gttcaatttc ttcttttaga aaagaaaact gattgaaaaa ttcctgcata ggatattgat
     8281 tgaattgata aattttgtca aatttgagat ttcctaaacc cttttgaaga ttagagaaaa
     8341 aggtcactgg actttgtttt ttatagattt gttcaatatc agaaaaatac tgcatatcag
     8401 aaaatgcttt actattctgt aattcttctg taaagtactg cgctaattct ctttcaaaga
     8461 cttcatactg attcatcaat ttttgataat catcaaagaa tattggagta tctttttcaa
     8521 tataatcaaa gacagtccat gtcttatcat agcacaaaga taaaaacttc cgagaatctg
     8581 catgactttg cttttgatga aaacttgaaa gaatttcttc taggtatgat ttcaaaatag
     8641 gtgataaagt ttttgaaatt tgtttttcta aagctgactg tcctcgttga taatcctttt
     8701 ctctcaaaag catatcacta gctggaaaga tagtgagttc tatcttattt tctttcgata
     8761 attgtgtttc tacttcaaat gacctgatac catcaatttc atcaccaaaa aactcaattc
     8821 gacaaggttc taactgggac atttcaaaaa tatctaaaat atctcctcga agactaaatt
     8881 cgccctgagt ttgtacttga gtaacttttc gatagccatt ttcctttaac tgatggataa
     8941 acgcgtgttg atcatattct tcaccaactg agatttttac aatactatct ttgaatgcat
     9001 tgggagacgg taaaatcaat cgacttgctg cgatattaca aactaaaatc cctttcttag
     9061 atgaatcagt caaaaaacgc aaggcttcaa cccgtgaaat aattttttcc tgtgaagaca
     9121 tcaaaaactc caccatagga gcatcatcta ccaaaaatgg atagacgagt tcctcaccca
     9181 agatagagat aagatcacta acaagtcctt ctgcttctcc ataagttgac gtcaataaca
     9241 caatcctatc ttctttttct aaactgcttg caattgcaag agccttagta gatgttgata
     9301 aaccaagtat tagttgtctt ttcttatctg ttaaattttg atgccatttt ttaatctgat
     9361 cattttctga gaataaatct aataaggtca ccatttatcc gttatacctc tgcattgttt
     9421 tctcaaaatt tttctcttgt aaatagtagt ttacagaatc gtcaactttg tcaacagact
     9481 gtaaaatacc gatataatca tccctgtcaa acttactcaa aacatgatga acaactgaca
     9541 taccattttt aggtcttcca attccaatct taacacggtt aaagacctga gttcctatat
     9601 gttgaataat agacttgata ccattatgac cacctgctga gccttttgct cttaaacgaa
     9661 ttttcccaac ttccatgtca agatcatcgt aaatgataag taaatcgtca atatccaaac
     9721 catagtaagt taataaagca tgaactgctt ttccactttc attcataaag gtcgttggtt
     9781 taaccagata aattttttct ccatttagga aaaaggatgc taggtcagct tgaaatatct
     9841 tatcgtgtgt aaaagtgaca ttctgtttct tcgctagttg atcaatcaac ataaaaccaa
     9901 cattgtgttt tgtttcaaaa tatttatccc ctggatttcc caagcctaca agtaatttgg
     9961 tcatttattt ttcctttcaa aagccaaaag ggttggaatt tttttccaac ctaattgaca
    10021 ccatttatta atttttagac attaaagcgg aattccatga tatcgccatc ttgaacgata
    10081 tattcttttc cttcttcacg caagcgtcca gcttctttta cggccttttc agatccgtat
    10141 ttcactagat cttcatatga catggttact gcacgaataa agcctttttc aaagtctgag
    10201 tggataatac cagctgcttg agtagccttc ataccacgtt tgaaagtcca agcgcgaact
    10261 tctttttcac cagctgtgaa gtaagttccc aatccaagca agtggtaagc tgcacgcgtc
    10321 aacttatcta cacctgattc tgtcaaacca atggcttcaa gaaactcttt tttatcttca
    10381 tcatccaatt cagaaatttc ttcctcagca cgcgcagaaa taacgactac ttcagcattt
    10441 tctgtcgctg caaattcacg aatttgtttg acatagtcga tagagtcagg ttctgaaacc
    10501 acatcctcgt ccacattagc tacataaaga actggtttag tcgtcaaaag gaaaagacct
    10561 ttgacaacct tttgttcctc atctgtaaat tcaatggtac gagctgattt cccgtcttct
    10621 aggactggtt taatcttttg aagaacattg aattctgcta ctgattcttt atctttttgc
    10681 gtacgtgcca tcttttctac acgcgcatat cgtttgttca ctgattctaa gtcagcaaga
    10741 attaattcca gattaattgt atcaatatct gcaagtggat ctacaaaggc gtcttcacgt
    10801 ccttgctcgc gcatcacatt ttcatcatca aaagcacgaa ctacgtgaac aatcgcatct
    10861 acttcacgaa tattggccaa gaatttattc cctagccctt ctccttttga agctcctttt
    10921 acaatccctg caatatccgt aaattcaaat gttgtgggaa ctgtcttttt aggagttatc
    10981 atttcagtta gtttttgtag gcgttcatct ggaacttcca ccattccaac atttggatca
    11041 atagtcgcaa atgggtagtt tgctgcctct gctcctgctt ttgtaattgc attaaatagt
    11101 gttgatttac caacgtttgg caaaccaacg atacctgctg tcaaagccat atttctcatt
    11161 ctccgttttc atttcaatcc ctaatattat aacacaaaaa gggataaagt gctaaccctc
    11221 taactaaggg ttctcagtca ataattttat tcatttttcg ctcaaaatca tatcgcccca
    11281 tcatgacaac atgctcacaa ttactgcatt ttattttgat atctgctcct acacgtgtaa
    11341 tttcccaacg attagccttt ttaccagttg acttgattgt acaagcgtgt gattttttca
    11401 tctcaacaaa atttccaact tgatacatac tactctcctt ttctttttcg attatatcat
    11461 aaaagaggcg agccaggctc aacctctttc acttaatttg tacgaactgg tgtaatgagc
    11521 tgcatgaagt cttcgtcagt atctgctggc acaagagtaa atggacgaac agctgagata
    11581 aagctaatgg tcaccttttc gctatttaaa gctttaagag aatcaatcaa gtaagttggg
    11641 ttgaaactaa tggtcaaatc ttcaccagta acctgatcag tatcgatttc ttcgtttact
    11701 ttaccaactt ctggagagtg aacatgggcg ctaacaaccc catccttaat ttcaagtttc
    11761 acagtaccat tttgagtcgc acttgataaa agacgggcac gctccattga ctggcgtaag
    11821 tttaccacat taaaagtaat agtagtgtta aagtctgttg gaatcaagcg atctgtatca
    11881 ggatagtttc cttctaggag acgagtatag aagctaatat tttcgcttct aaagaggatt
    11941 tggttattgg caaagaaaat ctctacagtt tcgatatcat ctgtaaatac cgctgaaaat
    12001 tcgcgtagag aacggctagg aattacgaca tcaaaatcat cactattttt ttcaagagtc
    12061 aattttttct ggcttaggcg atgagagtct gttgcaactg tttttaactc tttgtgttga
    12121 ctcaatacga agtggacacc tgttaaaatc ggacgactct cttgtgtact tgcagcaaag
    12181 gctgtttcat taataatttt cttgagtaat tttgtttcaa gtattaaagg agtgcttgct
    12241 gaaatttctt ggattcgtgg atattgttcg ctatcttttc cttttagggt aatttctgat
    12301 ttgccactgg ttaaaacaat ttgattttgt tcaatttctt taaaatcaag agttacatca
    12361 ggtaaactag atactacatt gataaagaaa gaagcttcaa gaaggatcga acctaaagaa
    12421 gtaattaaca aaccagcatc ttcatttttt tgagaaataa aattttcaat tgaaatttga
    12481 ccatttgaac caattaaagt aataccttca ttggtcacgt caatttttac tgttgataaa
    12541 ataggaatgg catttttaga actaatagct ctcttagtag tatttaatgc ttgtagaaat
    12601 aaatttttat taattgaaaa atgaatcatg gattctcctt tatttatttt tagtattaga
    12661 aagataatag taataataga gtctgtgaaa tctgtggaaa acagccttta aacaagtcat
    12721 atcaagtttt ttagcttgtt taaaaaatgt ggataaaaaa gataaaaaac taaaagttat
    12781 ccacaaatta tttgattttc tttttgattg attcaatttc taaacgtaaa ttatcgtctt
    12841 gatcaatcaa agattttatt ttggcatggg catgaatgac tgtggtatga tcttttcccc
    12901 caaattcctt cccaattttt ggaagactat tatctgttag ttctctagat aaatacatgg
    12961 ctacttgacg ggccaaaaca atattttgaa ggcgtctact tcccttcatt tctttgatac
    13021 taacaccata aaagttacca acttcagttt ggattttatc aattgggatg acgagcattt
    13081 ggctaacatc ttgtttgcgg gctctaatgg cttctgcagc aatatcaata gtgatatcct
    13141 tgattttttt tactctggca attaaagtga tgtcgttgat ggctccctca agatctcgaa
    13201 catttgaatc aaattgccca gctaggtatt ctagagtatc actttggaaa ttgtagccta
    13261 aatgttccgt tttactttgt aaaatggcaa tacgtgtttc aaagtcaggg ggtgtgatag
    13321 tttgtgtcaa tccccaacta aaacgcgtga caagcctctc ctcgagccct tctagatgtt
    13381 ttggactacg atcactcgtt aggacaatct gtttttgctt gtcatgaagg gcgttaaagg
    13441 tattgaaaaa ttcttcctga gttgcaactt tttttccgct gagtgactga atatcatcga
    13501 ttaacaaaag atcaagacta cgataggtct ttttaaactt ttccatttcc ccaagtctta
    13561 ggtgatcaag aaagtcatta ataaagcttt cggcagggat atatttaaca cgcgcattag
    13621 gaatattttt tagaatttca tttccaatag cgtttaataa gtgagtctta ccaaggcctg
    13681 gtcctccata gataaaaaga gggttatagg tcagagccaa atcttcagag acagctaaag
    13741 cggctgatac agcccaaaca tttccatccc cttgaataaa gttatcaaag gtatactttt
    13801 cttttaatcc cgtatctgaa taaggaatag atactaactt tggactatag ttataaagag
    13861 ttaaatttgt agcttcttca acttgtgagc tagtcgtatc ttgaggtttg gtgaaaatat
    13921 agtggggagt tatttcagcg tcataaattt caaaaccagc tactacaata atatctttta
    13981 gttgtttttc ccagaccatt tccatttcag agcgaggtag aaatatagtg gcaacatttt
    14041 cctctacctt gatgagttca gcttgaatag catagaaatc atacatggat cgagtcagtc
    14101 tttcttgtgc aaattctaat atacgattcc aaaattgttt ttctttcaat cctttctcct
    14161 cctttactat ttaaaagttt aatactagag atattttacc atagatagca agaattttcc
    14221 acaagctgtg aaaaataatc cacaatgtta ccaaacttta tccacaggtt ggggataaaa
    14281 gaagaaatta ttgatttatt aagcttttta tcgaaaaaca tagtggataa ccttgtgaga
    14341 taaaaaaata aaagaacagc cttatttcag gctgttgata attctactat attcttcttg
    14401 atttgaaaaa gaaataatga tttttccact gtctttttta gatagtttaa tttctacatc
    14461 taatccgagt agttttctta actgtttttc ttcattttgt atgaaatgat tagttttttg
    14521 ctgtttcttt tgttttttct ctgtcagaag agcttctaat ttccttacag aaatatcttc
    14581 ttctataatc cgttgaaaga aatagtcttg ttgttcctta tttaacccaa ctagggaacg
    14641 cgcatgggct tgtgatagtt tgccattttc tacttctgaa agaatctgtt ctggcaagga
    14701 aagtaaacga atggagttgc tgatatatgg acgagacttg cccatcttat ctgcaatttc
    14761 agcatgggtg aatcctttct ctacgagaga ttcataggcg cgtgcttctt ctattgggtt
    14821 taaattttct ctctgtaaat tttcaataat ggactggacc atcatctctt ggtctgaaat
    14881 ctgtttaaca acagctggga tagaccgtag accagctaaa agtgaagccc gatagcgtct
    14941 ctctcctgca aggatttcat aaccaataac aggagattga cgaacaataa tcggttgaat
    15001 gaccccattt tctttgatag actgtgctag ttcatctagt ttttctctat caaattcttt
    15061 tcggggttga tagggatttt tttgtatatc tgtgatagaa atcatttcaa atttttccat
    15121 gattctacac taacacatct tttctcttat gtaaagcttt ctttacatag atgtcaatca
    15181 agattctaaa tcacctgaac tcttgttaag tttgatagag gtagtttctt ctttcccgtt
    15241 acgatagtag gttatcttaa tggtgtctcc gatagaatgg ttgtaaagag cactttgtaa
    15301 gtctgttgat gaagcaatct ctttgtcatc tacttttgta attacatcgt atttttcaag
    15361 gtgaccattg gcaggcatat tactttgtac cgaacgaaca actacaccag atgtaacatt
    15421 acttggaata ttgagtcttc tgatgtcgct tgtactcaca ttagataaat taaccatctg
    15481 gattcccaaa gctggacgcg tcacttttcc gtttttttct aactgttcaa taatattgat
    15541 agcatcattt gcaggaattg cgaaaccaag accttctaca gatgttcctc catttgtagc
    15601 aattttactt gaggtaattc cgataacctg cccttgaata ttgatcagtg ggccgccaga
    15661 gttacctggg ttaatagcag tatcagtttg gatggctttt gtagaaatag cttgtccatc
    15721 ttccgatctt aaggatacat ttctattgag actggatacg ataccttgag tgacagtatt
    15781 tgcatattca gaacctaacg ggctaccgat ggcaatagca gtttctccta cagttaactt
    15841 actagaatca ccaaactcag ctactgttgt cactttttct gaagagattt tgacgacagc
    15901 aatatcagag aaagtgtcag ctccgacaat ttctccaggt actttagtcc catctgacaa
    15961 tctaatatct actttgctgg cgccatttat aacgtgattg ttggtgacga tgtaagcttc
    16021 tttatcattc tttttataaa taactccaga tccttcacta gagattcgct gagaatctgt
    16081 gtcagtatca tcattgccaa atacgctatt ttgtctgttt gccgaataag taataacaga
    16141 aacaacagca tcttttactt tgttaacagc ctgtgttgtt gaattttcgt tcttataggc
    16201 agtttgtgta atagtactat tgttgttaga gttgtttaca ctactttttt gagttagttg
    16261 agttattgaa aaactaccca aggctccact aaaaaagcta atgacgataa cgactaataa
    16321 ttgaaaccat tttttgtaaa atgtttttag atgtttcata tttgcctcca tatgtttgaa
    16381 ttactgaaag tataaactga ctagcttaat tataacttaa acacaaaagt tttacacaaa
    16441 ctgtggataa ctcttttgaa actgtgattt tcttaattga aatctatttt ttattttgtg
    16501 aataagatgt gaaaaaatag agaatatgtt agaatagagt catgaaaatt aaagttgtaa
    16561 cagttgggaa actgaaagaa aagtatttaa aagatggtat cgcagagtat tcaaaacgaa
    16621 tttctagatt tgctaagttt gaaatgattg agttatcaga tgaaaaaaca ccagataagg
    16681 ccagtgaatc agaaaatcaa aagattttag aaatagaagg tcagagaatt ttatcaaaaa
    16741 ttgctgaccg tgatttcgtt attgtgttag ccattgaagg gaaaactttc ttctcagaag
    16801 aatttagtaa gcagttagaa gaaacttcta taaaaggatt ttctactctt acttttatta
    16861 ttgggggaag tttaggattg tcatcatctg taaaaaatag agccaatctt tctgtcagtt
    16921 ttggtcgcct aaccttaccc catcagttaa tgagactagt tcttgttgaa caaatctatc
    16981 gcgcttttac gattcagcag ggattcccct accataaata gaaaattgac ttttaattga
    17041 atttttggta gaataattgt attagatctc atagctcagc tggatagagc attcgccttc
    17101 taagcgaacg gtcgcaggtt cgaatcctgc tgggatcaat ataatagcaa agctgggaat
    17161 tttcccggct tttttcttaa aaaagtacac tttgggagaa aaaaatgaca gttgagagaa
    17221 ttttatctaa aacgaaattc cattttgtat aatggttttt gtaagttagc ttacaagaaa
    17281 aaacatttta ggagatttta ttatgaaaaa cacagttaaa ttggaacagt ttgtagcttt
    17341 gaaggaaaaa gacttacaaa agattaaagg tggggagatg aggttgtcaa aattcttccg
    17401 tgattttatt ttacaaagaa aaaagtaatg aaataagggg aaagagtaat ggatttattt
    17461 ggatttggga cggttattgt tcatttttta attattagtc acagttacca ttttatttgt
    17521 aaaggtcaaa taaatagaaa agaattattc gtttttggtg cttatacatt actaacagaa
    17581 atagtatttg attttccctt atatattcta tatttagatg ggttagggat tgaaagattt
    17641 ttatttcctt tgggattata ttcctatttt cgatggatga aacagtatga gagggataga
    17701 ggactattcc taagtttact actatctctt ttatatgaga gcactcataa ctttctgtcc
    17761 gtaactttct cctctataac aggagataat tttgttttac aatatcattt cccattcttt
    17821 ttcgttgtga cggtgttaac ctattttgtt acattaaaaa tcatttacta tttccatttg
    17881 gaactagcct attttgacga ggactacctt tatcctttct tgaaaaaagt attttttgct
    17941 ttactattgc tacatattgt atctttcgtt tcagatatgg taagtacgat taaacatttg
    18001 aatagttttg gaagtatttt gtcatctatt gtctttatct ctctcctttt gaccttcttt
    18061 gcaatgaatt ctcataaagt tcaaatggag aaagagattg ctttgaagca gaagaaattt
    18121 gaacagaaac atttacagaa ttacacagat gaaattgttg gtctgtataa tgaaatccgt
    18181 ggttttcgac atgattatgc tggaatgctt gtcagcatgc agatggcaat tgacagtggt
    18241 aatttacagg aaattgacag aatttacaat gaagttttag tcaaagcaaa tcataaattg
    18301 cgttcagata agtacactta ctttgatttg aacaacatag aagactcagc tttacgaagt
    18361 ttggttgctc agtcaattgt ctatgctcga aataatggtg tagagtttac actggaagta
    18421 aaagatacga ttaccaagct tccaattgaa ctattggatt tggttcgtat catgagcgtt
    18481 ttattgaata atgctgtcga aggatcggct gatagctata aaaagcagat ggaagtagca
    18541 gttattaaga tggaaactga aacagttatt gtgattcaga attcatgtaa aatgacgatg
    18601 actccttcag gagatctatt tgccttagga ttctccacta agggaagaaa tcgcggagtc
    18661 ggattaaata atgtgaaaga actactagat aagtacaaca atattatttt agaaacagag
    18721 atggaaggca gtacatttag acaaatcatt agatttaaga gggaatttga atgaaagttt
    18781 taattttaga agatgttatt gaacatcaag tgagactaga gagaatattg gatgaaattt
    18841 cgaaagaatc gaatattcca atatcataca agacaacggg aaaagtccgt gaatttgaag
    18901 aatacattga aaatgatgaa gtaaatcagc tttatttcct agatatcgat attcatggaa
    18961 ttgagaaaaa gggatttgaa gtggctcagc tcattcgtca ttacaatcct tacgctatta
    19021 tcgtctttat cactagtcga tcagagtttg cgactctaac ctataaatac caggtatcag
    19081 ccctagattt tgttgataag gatatcaatg atgagatgtt taagaagaga attgagcaaa
    19141 atatcttcta cacgaagagt atgttacttg aaaatgaaga tgttgtagat tatttcgact
    19201 acaattacaa gggaaatgat ttaaaaattc cttaccatga tattttgtat attgaaacaa
    19261 caggggtatc tcataaattg cgcattattg gtaagaattt tgcaaaagag ttttatggta
    19321 ccatgacaga tattcaggaa aaggacaaac atactcagcg attttattct cctcacaagt
    19381 catttttggt aaatataggc aatatcagag aaattgatcg aaaaaactta gaaattgttt
    19441 tctatgaaga ccatcgttgt cctatttcaa gattaaaaat tagaaaatta aaagatattt
    19501 tagagaaaaa atctcaaaag tgattgacaa ttagcaagaa attgatataa tggttatatc
    19561 tgctacagat agaaggtccg ttggtcaagg ggttaagaca ccgccttttc acggcggtaa
    19621 cacgggttcg aatcccgtac ggactatttt atccgccata gctcagttgg tagtagcgca
    19681 tgactgttaa tcatgatgtc gtaggttcga gtcctactgg cggagtatag ataaaaggga
    19741 acacagctgt gttcctcttt ttgtatcaat ttgtatcacc aagcattttc ataaggaagt
    19801 ctgttatttc ttgagaactt tctttttttc catgtgcaat ccaagtttgg cagacaccaa
    19861 aaagtgcatg agttagatag atgctactat attctaattc agtggtattt agattcagtt
    19921 gcataaatcg cttttgtaaa tctgtactaa gcatgatatg aagtttattt cgtaagaaat
    19981 tttggatttc tttagtccca ttttcagaaa gaagggcagc cagaagtggt tctgactcta
    20041 gatattcaaa aacttctaaa atagcgtctc ttttgtgatg agcatgtttt tgaaaaatat
    20101 attcaaatgt atggaatagc ttgctttgat agtgctcaat catatcatac ttatccttat
    20161 agtgagtata gaagctggaa cgactaattc cggctttttc tactaatttg acagtagaaa
    20221 ttttatcaaa tggctgttcc atcagtaatt gtaccatagc attttcaata gttcgctttg
    20281 tttttaagcg tttgttactt tcttgcatat ttcctccttg taaacaaatt agactatatg
    20341 tctaaaaata gattttttat cttgtaattt agatttttta atgtataatc tattatatca
    20401 aaattttaga caatatgttt aaaaaaggag aaactaagtt taaagaatgg aaagcaattt
    20461 aaaaaaaacc aacctttatt attgtcatga tcgggatttc tcttattcca gatctgtaca
    20521 atatcatatt tttgtcatca atgtgggatc catatgggca attgtctgac ttacctgtgg
    20581 cagttgtaaa taatgataaa gaggcttcct ataatggtaa tactatggca ataggaaaag
    20641 acatggtgtc caatttaaaa gaaaataaaa ccttggattt tcattttgta gatgaagagg
    20701 aaggaaagaa gggattggaa gatggcgatt actatatggt agtgacttta ccaagtgatt
    20761 tatctaaaaa aacaactaca ttatccaata ttcaatcgac agcagcttat caatcattga
    20821 caagtgagca acaaactggg ataagtgatt ctgtatctca aaattcaact gatagtattc
    20881 aatcggctca gtcaattgta gctttagtac aaggtttaca gggaagttta gaaaacttac
    20941 aaaatcaatc ttctaatctt tcgactttaa aaaatcaagc taatcaagta ttacctatta
    21001 cttctacttc tttgatagga ttgtcaagtg gattaacaga gatacaagga gctgttacta
    21061 gcaaattagt tcctgccagt cagttgattg catcaggtgt aaacgcatat actacaggtg
    21121 ttgataaagt ttctcagggc gcaagtcaac taagtgaaaa aaatgccacc ttgacaggta
    21181 gtttggataa actagtttca ggctcaaaca ccttgacaca aaaatcttct agattgacag
    21241 caggagttgg ttaattacaa tcaggatctg ggcaattagc agacaaatcc agtcagttac
    21301 tttcaggtgc ttctccatta gagaatagag ctaataaatt ggcagatgga tctgggaaac
    21361 tagcagaagg tggaacaaag ttaacttctg gattggaaga tttacagaca ggacttgctt
    21421 ctttaggaca aggactaggt aatgctagtg atcaactcaa atcagtatca acagaatcta
    21481 aaaatgcaga gattttgtca aatccactca atctttcaaa aacagacaat gatcaagttc
    21541 ctgtaaatgg aatcgcaata gctccttata tgatatcagt tgctcttttt tttgcagcaa
    21601 tatcaacaaa tatgatattt gcgaaattgc cttcaggacg tcatccagag agccgttggg
    21661 cttggttgaa atcttgagct gaaataaatg gtattatagc tgttttggca ggaattttgg
    21721 tatatggagg agttcagctt attggtttaa ctgctaatca tgagatgaga atatttattc
    21781 tcatcatcct aacaagttta gtattcatgt ctatggtgac cactttagca acgtggaata
    21841 gccgtatagg agcttttttc tcacttattt tgcttttact acagttagca tcaagtgcag
    21901 gtacttatcc acttgctttg acaaatgatt tctttagatc tattaatccc tggttaccaa
    21961 tgagctattc agtttcggga ttacgataaa caatctctat caacaagtca ttttcctagc
    22021 tgtcatacta gctctattta ctggtttagg tatgctagcc tatcaacata agaaaatgga
    22081 agaagattaa aaaaatcgac cgattaactg gtcgattttt tatgccttag atgactttcg
    22141 tctgtgatta tagattccaa atagtaagag agaagtaaag gaacagattg ctccagtaat
    22201 aaaaccattg ggaatgaagg aaagtgtaat agttcctttc cccttgggaa tgtcaacttt
    22261 cataaatcca gtttgagctt gtttaatttc tattttctta ccatcttggt aggcagacca
    22321 acctttgtca taaggaatgg tgaagaaaat agatgtatct tgttggacat catatgtagc
    22381 aaaaaccttg tttttagaag ttgatactgt gacaggttgt tctttaattt tttgaattgc
    22441 ctcggtgaaa gttttggtat ctaaacgata gaaggtagga gattcaaatg atacttgtga
    22501 atttccaggg aaactaacat tgatattgaa agtttttttc tctttagtat atcctagatt
    22561 aaagaaggag aagacattat cagttgtaaa agtctttttt tcaccattta caagtatgtc
    22621 aaccttcttt tgtttatcgt tagaaaagtg aaggtttatg aaagagagat aaacttggct
    22681 gttttctgga acttcaattt gatactggat tgctgcatct tcatttgaag aacttgtgac
    22741 actaatcaaa tcattagtat tttctatttt ttctgttttt tcataaggta ttggagaaaa
    22801 ataatcaaaa ttgacgttag caagttgatt taaaaatgag gcctgattat ccaaggtatg
    22861 ttcattgaac ttgacatcat tgtaaacaga ttgactagca actgcaatcg gaagagagta
    22921 ttgattttca tatagggtaa gattatcttt ttgatagata tctttaaagc catacttatc
    22981 aataggactg tctgagatat tgtactggat accaaataaa ctatcagcca aaatactatt
    23041 atttgcatat cggagattga gattagtccc agaggattta aaaccaagtt tatctaaagt
    23101 agagcttgat gaacgatttc gaacagatga aaattgagag attccattgt agttgaattt
    23161 catactgtca tttcctgtct gagtttgtag tttttcagta cgagtaaatt gatttccaat
    23221 atatgttgag aaagattcca tagctgggat atctcgacta taagcacttc gagaagcaaa
    23281 tccccattcc ttagcaattc cgtccatttg agatgaagca tttaaactca tttcaaccag
    23341 tataaataaa gagattagaa tggcaaatag attcacagat ataaactttt tgataactgc
    23401 aaggagtaaa agagaataga caaccaaaaa ttcaagagta agcagaatat tcaaatctgt
    23461 taaaaaagaa taatgcgatt ttagatagat ggtagctaaa aatcctgcta ctacaagaaa
    23521 aagcgaaact aaaaaattcc agactttaag ttctttcaga cgctttaaga cttctgctgc
    23581 tgtgtaaatt aacaaggtag agaaaatcca agcatagcga tgtaaaaaca tgtttggagt
    23641 atgcatgcct tgccaaaata agtcaagagc ttctatgtaa aagcttgcaa ttagaaatgc
    23701 aaagaatatt acatatatga gtttcacgtg aaacttaata gatttcagcg taaaaaataa
    23761 aatggtcaaa ataaagggaa atagtccaac aaaaatcatt gggatggccc catactttgt
    23821 tgtgtcaaag gaaccaatga attgcttagc aaagagatca agataccagc tactttcagt
    23881 ttgaaacttt gtaacttcag tcaatttttc cccatgtgtc tgtaaatcaa atagagtggg
    23941 aagagtcata atcaaactag ccataccagc taaaaaggag ataactatga aatcaagaac
    24001 agatgatttt cgagtcttaa agtcccacga aatttgacag agataccaga aaataagaaa
    24061 caatactgtc atatatccaa aataataatt ttgaataaat aagattgaca gacttgtaaa
    24121 gtacaatagg agtttctttt cagttatcag tagatgtaaa ccagttataa ttaaaggaat
    24181 caagataaaa acatctagcc aggtttttat ctctaattga ctgacagtga aactcatcag
    24241 agcataggaa gtagataagg ctagttttaa agtctgaggg atagattgaa acaatttatt
    24301 caaactaaaa aaggttgaca gaccaatcaa tccaaatttt aagagagtgg tcagatagac
    24361 agcatctggc atattcgtta gatcaaaaaa gtaaactaga ggcgcgagaa aactacccaa
    24421 gtaataacta gatagggcat agaagtttag ccctagacca cttgtaaagg tgtaaaacag
    24481 actactattt ccatgtagga tatttcgtaa ggctacatca aaaataacgt attgatgaaa
    24541 gccatctcct aatagaggag agttgtcgct attccagtag ataccttgag atagatatac
    24601 tccagacata atcactacag gaatgatgaa agaaataaaa taggttcgat atgtttttaa
    24661 aaatgatttc atgttacctc gtagaatgat agaaaactca gttggttaac ccaactgagt
    24721 tttgaagttt tatttagtct ttccaaagtt ctttaacttt tgcttgtact tctgcatttt
    24781 ctaggaattc atcgtaggtt tcatcgatac ggtcaatgac gccattttta gataagacaa
    24841 tgatatggtt agccaaagtt tgaataaatt cgtggtcatg gctagcaaag atgattgatt
    24901 ctttaaagtt tttcaatcca tcattcaagc ttgagataga ttccaagtcc aagtgatttg
    24961 ttggatcatc aagtacaagg acatttgatt ttaagagcat gagttttgaa agcatgacac
    25021 gaactttttc tccccctgac aagacattta caggtttgtt aacttcatct ccagagaaga
    25081 gcatacggcc gaggaaacca cgtaggaaag tattgtcatc ttcttcttta cttgcgaatt
    25141 gacgcaacca gtcaagaatt gattctcctc ctgcaaaatc agctgagtta tcttttggta
    25201 ggtaagattg actagttgta actccccact tgacagttcc ttcatagtca atatctccca
    25261 tgattgcacg aattaatgca gtcgtttgaa tatcattttg tccaataagt gctgtcttat
    25321 catctggacg caagatgaaa ctaatattat ccaagatagt ttcaccatca atctttacag
    25381 ttagattttc tactgtcaag agatcattac caatctcacg ttccgcttta aagttgataa
    25441 atggatattt acgactagat ggtacaatct cttctagctc aatcttatca agcattttct
    25501 tacgtgatgt tgcctgcctt gacttagaag cattggcaga gaaacgagca acgaattctt
    25561 gcaattgttt aattttttct tctgctttag cattacggtc tgctagcaat ttagcagcaa
    25621 gctcagaaga ttccttccag aagtcgtagt ttccgacata gagtttgatt tttccaaagt
    25681 caaggtcggc catgtgagta caaactttgt ttaagaagtg acggtcgtgg gatactacga
    25741 taactgtgtt atcaaagtca atcaagaagt cttctaacca agtaatcgat tggatatcca
    25801 aaccgttagt aggctcgtcc aagagaagaa catctggttt accaaaaagt gctttggcga
    25861 ggagaacctt tactttttca ccgttggcca attcgctcat gttttggtag tgtaattctt
    25921 ctggaatgtt taggttttga agtagttgag aggcttcact ctctgcttcc caacctccaa
    25981 gttcggcaaa ctctccttcg agttcggcag cacgaacccc gtcctcgtct gagaaatctt
    26041 ccttcatgta gatagcatct ttctctttca tgatgctata aagtttttca tttcccatga
    26101 taacgacatc aatggcacgt tcatcttcgt agtcaaagtg attttgacga agaacagaga
    26161 gacgttcatc tggaccaaga gagatgtgac cagtagtagg ttcgatatct ccagctaaaa
    26221 tttttaaaaa ggttgatttt ccggcaccat tagcaccgat taatccgtaa gtatttcctt
    26281 ctgtaaattt gatattgaca tcatcaaaaa gtttgcgatc actaaaacgt agtgaaacat
    26341 cagatactgt aagcaatatt tttctcctat atgtgtaata tatttattct actagaaaat
    26401 acagaaatat tcaaattttt atttgtcaat tttgtgtaaa ttatatttac agtatccttt
    26461 acacaaatct gtaaaaagca aggctgattt attttgataa attacggtta tttcattaaa
    26521 aaaatgctat aattgaaagg actatatcga aggagaacaa aatgactaaa cccattattt
    26581 taacaggaga ccgtccaaca ggaaaattgc atattggaca ttatgttgga agtctcaaaa
    26641 atcgagtatt attacaggaa gaggataagt atgatatgtt tgtgttcttg gctgaccaac
    26701 aagccttgac agatcatgcc aaagatcctc aaaccattgt agagtctatc ggaaatgtgg
    26761 ctttggatta tcttgcagtt ggattggatc caaataagtc aactattttt attcaaagcc
    26821 agattccaga gttggctgag ttgtctatgt attatatgaa tctagtttcg ttagcacgtt
    26881 tggagcgaaa tccaacagtc aagacagaga tttctcagaa aggatttgga gaaagcattc
    26941 cgacaggatt cttggtctat ccaatcgctc aagcagctga tatcacagct ttcaaggcta
    27001 attatgttcc tgttgggaca gatcagaaac caatgattga gcaaactcgt gaaattgttc
    27061 gttcttttaa caatgcatat aactgtgatg tcttggtaga gccggaaggt atttatccag
    27121 aaaatgagag agcagggcgt ttgcctggtt tagatggaaa tgctaaaatg tctaaatcac
    27181 taaataatgg tatttattta gctgatgatg cggatacttt gcgtaaaaaa gtaatgagta
    27241 tgtatacaga tccagatcat atccgcgttg aggatccagg taagattgag ggaaatatgg
    27301 ttttccatta tctagatgtt tttggtcgtc cagaagatgc tcaagaaatt gctgatatga
    27361 aagaacgtta tcaacgaggt ggtcttggtg atgtgaagac caagcgttat ctacttgaaa
    27421 tattagaacg tgaactgggt cctattcgtg agcgccgtat tgaatttgct aaggatatgg
    27481 gagaagttta taatatgatt caaaaaggta gtgaaagagc gcgtgaagtt gcgggtcaaa
    27541 ccctatctga ggtaaaaggg gcaatgggac ttcattactt taactaagtt tattttgcaa
    27601 gaaactatct tttctatctc gaagaaaaga tagtttttta tttacccctg taacatttga
    27661 caaattttta tagaatggta tgatagatac aatataaaaa gagtcaagct caaaaagaaa
    27721 gaaaagagga aacttcgaat gtctaattgg gacactaaat ttttgaaaaa aggttttacc
    27781 tttgatgatg tattgcttat tccagctgaa agtcatgtgt tgcctaacga tgcagattta
    27841 acaactaaat tggcagataa tttgacttta aatatcccaa ttattaccgc tgccatggac
    27901 acagttacag agagtcaaat ggccattgct attgctcgtg caggcggtct cggagttatc
    27961 cataaaaaca tgtcaattgc tcaacaagca gacgaggttc gtaaggtaaa acgttctgaa
    28021 aatggagtta ttattgatcc gttcttcttg acgcctgaac atacaattgc tgaagcagat
    28081 gagcttatgg gtcgttaccg catcagtggt gttccagttg ttgaaacact tgaaaatcgt
    28141 aaattggttg gtattttgac aaaccgagat cttcgtttta tttcagatta taatcaacca
    28201 atttcaaacc atatgactag tgaaaatctt gttactgctc ctgtgggtac ggatcttgca
    28261 acggctgaga gtattcttca ag
//
LOCUS       DBERMM010000023        27472 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.023, whole genome shotgun sequence.
ACCESSION   DBERMM010000023 DBERMM010000000
VERSION     DBERMM010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 27472)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27472)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27472
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.023"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            160..882
                     /locus_tag="ACL8AS_001275"
     CDS             160..882
                     /locus_tag="ACL8AS_001275"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HGS1229129.1"
                     /translation="MRLDKFLVACAVGSRTEVKNLLKAGRVTVNGKKEKSAKLQIDEK
                     IDEIRFDGQVLEYEEFVYYMMNKPKGVISATEDPKHRTVLDLLDDLARSKEVFPVGRL
                     DIDTHGLLLLTNNGQLAHVLLSPKRHVDKTYQAQVKGIMTQEDVETFIKGIPLKDFTC
                     QPARLEILSTDAEKNQSQIRVTIAEGKFHQIKRMVGYCGKEVVDLQRLTMGTLVLDEN
                     LERGEWRRLTKEELEILRANII"
     gene            1099..2433
                     /gene="pepC"
                     /locus_tag="ACL8AS_001276"
     CDS             1099..2433
                     /gene="pepC"
                     /locus_tag="ACL8AS_001276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000991632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase C"
                     /protein_id="HGS1229130.1"
                     /translation="MNAIQESFTDKLFANYEANVKYQAIENAASHNGIFAALECRQSH
                     VDNTPVFSLDLTKDKVTNQKASGRCWMFAALNTFRHKLISQYKLENFELSQAHTFFWD
                     KYEKSNWFLEQVIATSDQELTSRKVSFLLQTPQQDGGQWDMVVSLFEKYGVVPKSVYP
                     ESVSSSSSRELNAILNKLLRQDAQILRDLLVSGADQATVQAKKEDLLQEIFNFLAMSL
                     GLPPRKFDFAYRDKDNNYKSEKGITPQEFYKKYVNLPLEDYVSVINAPTADKPYGKSY
                     TVEMLGNVVGSRAVRYINVPMERLKELAIAQMQAGETVWFGSDVGQLSNRKAGILATD
                     VYDFESSMDIKLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKSTKWKVENSWGEKVG
                     TDGYFVASDAWMDEYTYQIVVRKELLTAEEQAAYGAEPIVLAPWDPMGALAE"
     gene            complement(2489..3400)
                     /locus_tag="ACL8AS_001277"
     CDS             complement(2489..3400)
                     /locus_tag="ACL8AS_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HGS1229131.1"
                     /translation="MTEKLQLTKSDRKKVWWRSTFLQGSWNFERMQNLGWAYTLIPAI
                     KKLYTKKEDQIAALERHLEFFNTHPYVAAPVMGVTLALEEERANGVEIDDAAIQGVKI
                     GMMGPLAGIGDPVFWFTVRPILGSLGASLALTGNILGPLLFFVAWNLIRMSFLWYVQE
                     IGYKAGSEITKDMSGGILQDITKGASILGMFILAVLVQRWVNIKFAFDVSKVQLDEKA
                     YIHWDKLPEGSKGIQEAFAQVGQGLSQTPEKVTTFQQNLDMLIPGLSGLLLTLLCMYL
                     LKKKVSPITIILALFAVGIVAHVLHIM"
     gene            complement(3424..4227)
                     /locus_tag="ACL8AS_001278"
     CDS             complement(3424..4227)
                     /locus_tag="ACL8AS_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0034219 - carbohydrate transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter subunit
                     IIC"
                     /protein_id="HGS1229132.1"
                     /translation="MSIISMVLVVVVAFFAGLEGILDQFQFHQPLVACTLIGLVTGHL
                     EAGIILGGSLQMIALGWSNIGAAIAPDAALASVAAAIIMVLGGDFTKTGIGVAQAVAI
                     PLAVAGLFLTMIVRTISVGLVHTADAAAKKGDFGAVERAHFIALLFQGLRIALPAALL
                     LMVPTETVQSILSAMPDWLKDGMAIGGGMVVAVGYAMVINMMATREVWPFFALGFVLA
                     AVSDITLIGFGAIGVAIALIYLHLSKTGGNGGGGAATSNDPIGDILEDY"
     gene            complement(4255..5244)
                     /locus_tag="ACL8AS_001279"
     CDS             complement(4255..5244)
                     /locus_tag="ACL8AS_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1229133.1"
                     /translation="MSIGIIIASHGEFAAGIHQSGSMIFGEQEKVQVVTFMPNEGPDD
                     LYAKFNNAVAAFDAEDEVLVLADLWSGSPFNQASRVMGENPERKFAIITGLNLPMLIQ
                     AYTERLMDAAAGVEKVAANIIKEAKDGIKALPEELNPVEEVASAAAAPVAQTAIPEGT
                     VIGDGKLKINLARLDTRLLHGQVATAWTPDSKANRIIVASDNVAKDDLRKELIKQAAP
                     GNVKANVVPIQKLIEISKDPRFGETHALILFETPQDALRAIEGGVPIKTLNVGSMAHS
                     TGKTLVNTVLSMDKEDVATFEKMRDLGVEFDVRKVPNDSKKDLFDLINKANVK"
     gene            complement(5478..6497)
                     /gene="adhP"
                     /locus_tag="ACL8AS_001280"
     CDS             complement(5478..6497)
                     /gene="adhP"
                     /locus_tag="ACL8AS_001280"
                     /EC_number="1.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="HGS1229134.1"
                     /translation="MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHV
                     AHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRET
                     LCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
                     EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVE
                     DVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTV
                     LDGIQVIGSLVGTRKDLEEAFQFGAEGLVAPVVQKRPVEDAVAIFDEMEKGQIQGRMV
                     LDFTH"
     gene            complement(6836..7648)
                     /locus_tag="ACL8AS_001281"
     CDS             complement(6836..7648)
                     /locus_tag="ACL8AS_001281"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HGS1229135.1"
                     /translation="MTKKIIAVDLDGTLLNSDSQISDFTKKTIKKVAEKGHQVIITTG
                     RPYRMSKDFYRELGLDTPMINFNGSLTHLPDQVWDFEKCLTVDKKYLLDMVQRSEDIQ
                     ADFIAGEYRKKFYITNPNEEIANPKLFGVEAFQPEDQFQPELVTKDPNCILLQTRASD
                     KYALAKDMNAFYQHQLSINTWGGPLNILECTPKGVNKAFALDYLLKIMNRDKKDLIAF
                     GDEHNDTEMLAFAGKGYAMKNANPELLPYADEQISLTNDQDGVAKTLQDLFL"
     gene            7838..9256
                     /locus_tag="ACL8AS_001282"
     CDS             7838..9256
                     /locus_tag="ACL8AS_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HGS1229136.1"
                     /translation="MDKLFKLKENGTDVRTEVLAGLTTFFAMSYILFVNPQILSQTGM
                     PAQGVFLATIIGAVAGTLMMAFYANLPYAQAPGMGLNAFFTFTVVFGLGYSWQEALAM
                     VFICGIISLIITLTNVRKMIIESIPNALRSAISAGIGVFLAYVGIKNAGLLKFTIDPG
                     NYTVVGEGADKAQATIAANSSAVPGLVSFNNPAVLVALAGLAITIFFVIKGIKGGIIL
                     SILTTTVLAIAVGLVDLSSIDFANNHVGAAFEDLKTIFGAALGSEGLGALVSDTARLP
                     ETLMAILAFSLTDIFDTIGTLIGTGEKVGIVATNGENHQSAKLDKALYSDLIGTTVGA
                     IAGTSNVTTYVESAAGIGAGGRTGLTALVVAICFAISSFFSPLLAIVPTAATAPILII
                     VGIMMLGSLKNIHWDDMSEAVPAFFTSIFMGFSYSITQGIAVGFLTYTLTKLVKGQVK
                     NVHAMIWILDALFILNYISMAL"
     gene            9309..10016
                     /locus_tag="ACL8AS_001283"
     CDS             9309..10016
                     /locus_tag="ACL8AS_001283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysostaphin resistance A-like protein"
                     /protein_id="HGS1229137.1"
                     /translation="MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVAL
                     LQSGLIVAGLSIVVLVLFIIGARKTQLASFNFSFFRTKDLARLGLSYLVIICSNILGS
                     ILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKE
                     NLGFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAF
                     CLLALVVIMSRTLGISV"
     gene            10111..11085
                     /gene="folP"
                     /locus_tag="ACL8AS_001284"
     CDS             10111..11085
                     /gene="folP"
                     /locus_tag="ACL8AS_001284"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HGS1229138.1"
                     /translation="MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGKFFALEQ
                     ALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDT
                     WKSQVAEAALAAGADLVNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSSLI
                     FPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGL
                     TKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTAS
                     AHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK"
     gene            11087..12409
                     /locus_tag="ACL8AS_001285"
     CDS             11087..12409
                     /locus_tag="ACL8AS_001285"
                     /EC_number="6.3.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="HGS1229139.1"
                     /translation="MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVLHI
                     GGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMADY
                     QSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILT
                     GITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALTVIDRIAEEKDAPR
                     LAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQE
                     DGRELASNDFLGQALEETSWPGRLEIVSRDPLMILDGAHNPHAIKALLVTLQERFADH
                     HKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATDESVLKEAAKSRNLSYQD
                     WHDFLEQNLTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENGYTKD"
     gene            12390..12944
                     /gene="folE"
                     /locus_tag="ACL8AS_001286"
     CDS             12390..12944
                     /gene="folE"
                     /locus_tag="ACL8AS_001286"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA];
                     GO_process: GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HGS1229140.1"
                     /translation="MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGL
                     GQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKL
                     ARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPGTATL
                     TTVARGLFETDKDLRDQAYRLMGL"
     gene            12987..13799
                     /gene="folK"
                     /locus_tag="ACL8AS_001287"
     CDS             12987..13799
                     /gene="folK"
                     /locus_tag="ACL8AS_001287"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003848 -
                     2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
                     diphosphokinase activity [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HGS1229141.1"
                     /translation="MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATD
                     LDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWA
                     PVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
                     EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFV
                     EDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALKK"
     gene            complement(13844..14161)
                     /locus_tag="ACL8AS_001288"
     CDS             complement(13844..14161)
                     /locus_tag="ACL8AS_001288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF960 domain-containing protein"
                     /protein_id="HGS1229142.1"
                     /translation="MAFTNTHMRSASFGIVTSLPDDIIDSFWYIIDHFLKNVFELEEE
                     LEFQLLNNQGKITFHFSSQHLPTAIDFDFNHPFDPRYPPRVLVLDMDGRETILLPEEN
                     DLF"
     gene            14517..14963
                     /gene="rplM"
                     /locus_tag="ACL8AS_001289"
     CDS             14517..14963
                     /gene="rplM"
                     /locus_tag="ACL8AS_001289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HGS1229143.1"
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKP
                     TFTPHTDTGDFVIVINAEKVKLTGKKATDKIYYTHSNHPGGLKQISAGELRSKNAVRL
                     IEKSVKGMLPHNTLGRAQGMKLKVFVGAEHTHAAQQPEVLDISGLI"
     gene            14982..15374
                     /gene="rpsI"
                     /locus_tag="ACL8AS_001290"
     CDS             14982..15374
                     /gene="rpsI"
                     /locus_tag="ACL8AS_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HGS1229144.1"
                     /translation="MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADL
                     RLVINQPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAG
                     LLTRDSRKVERKKPGLKKARKASQFSKR"
     gene            complement(15635..16057)
                     /locus_tag="ACL8AS_001291"
     CDS             complement(15635..16057)
                     /locus_tag="ACL8AS_001291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HGS1229145.1"
                     /translation="MRFIVETFPIFSISNDLLQLLTSWKKQQKYELAKFGIISNPEQF
                     IFTYIDTKGNINKPLHSDYLNNKMKTIRKRHPELTHATPHKLRHTGATLAKQAGMSLE
                     TISEALIHSDTGTTQIYVNTSNVVPMAVGEFALQSLKQ"
     gene            16204..16380
                     /locus_tag="ACL8AS_001292"
     CDS             16204..16380
                     /locus_tag="ACL8AS_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229146.1"
                     /translation="MSLDIDKEKMTIMGIAFENRSVFKSVWYALSTNMIEGWRPTVSD
                     VEKLRDEALALGMT"
     gene            16781..18994
                     /locus_tag="ACL8AS_001293"
     CDS             16781..18994
                     /locus_tag="ACL8AS_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="HGS1229147.1"
                     /translation="MKIFKGEFYRISVLTDKLVRLEYSKTGSFEDRTTQLIYNRDFGQ
                     VSLDYIETSNVLDIMTDYFHLHFNKGEFNAENLFIELKGNFAVYGSRWYFGESIETLK
                     GTARTLDKADGAIPLEDGIISRNGIALLDDSQGFIWDEQSGYIERENQIDLYFFAYGH
                     DYRGAIRDFYHLTGSTPLLPRYALGNWWSRYWPYTSDEYLDLIDRFETEKIPLSIGVL
                     DMDWHITDIPARFGSGWTGYSWNKNLIPNPEQLLQQLHDRKLKLSLNVHPADGIRAYE
                     EAYPQVAKRLGLNVELEEPAIFDFFNPSFREAYFKDVHYELEKQGVDFWWIDWQQGTQ
                     GILDPLWLLNHYHYQDSCKNAEGGLILLRYAGPGSHRYPVGFSGDTIISWNSLRFQPY
                     FTATASNIGYSWWSHDIGGHMLGDYDEELQTRWLQFGVFSPITRLHSSRSPFNSKEPW
                     FFSETTSKIMKKYLRLRHQMIPYLYTMNVKTHEEGAPLISPMYYFYPENDESYNVPNQ
                     YFFGTELMVAPIVEKMDLAFQSAKVDVWFPEGEWYDFFSEKKYTGGVKLSVYRDISTI
                     PVFAKSGAIIPLVGSEIDMGVDLPEVVDWYVFPGKQHSFEMLEDQNGQRYKTRLSIDW
                     EMGMVELTLQGDSSIVPSNRRHRIHFKGTNVSIIELPNKNDTARFECKDNKTISLNDE
                     VFRLLKTASLPYELKDRLLNQFINAKNSHDLMNILHHQDKELRGRLLEMIFTSQN"
     gene            complement(19216..19692)
                     /locus_tag="ACL8AS_001294"
     CDS             complement(19216..19692)
                     /locus_tag="ACL8AS_001294"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004602 - glutathione peroxidase activity
                     [Evidence IEA];
                     GO_function: GO:0043295 - glutathione binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione peroxidase"
                     /protein_id="HGS1229148.1"
                     /translation="MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQG
                     LQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKE
                     ADPLYVWLKDQKSGPLGKRVEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL"
     gene            19915..23118
                     /locus_tag="ACL8AS_001295"
     CDS             19915..23118
                     /locus_tag="ACL8AS_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored hyaluronate lyase"
                     /protein_id="HGS1229149.1"
                     /translation="MQTKTKKLIVSLSSLVLSGFLLNHYMTVGAEETTTNTIQQSQKE
                     VQYQQRDTKNLVENGDFGQTEDGSSPWTGSKAQGWSAWVDQKNSSADASTRVIEAKDG
                     AITISSPEKLRAAVHRMVPIEAKKKYKLRFKIKTDHKVGIAKVRIIEESGKDKRLWNS
                     ATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQLSEDSQT
                     DKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKE
                     VKKIPLKILASVKDAYTARLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSI
                     SSQADRTYLWEKFSNYKMSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSME
                     WLHKHVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDP
                     EHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGF
                     YQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKSPIDKDKMQTMYHWIDKSFAP
                     LLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQ
                     SDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRPSYLSAFNKMDKTAMYNAEKGFGF
                     GLSLFSSRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTE
                     TDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFL
                     GSNIQNTSTDTAATTIDQRKLESSNPYKVYVNDKEASLTEQEKDYPETQSVFLESFDS
                     KKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNGDSYGYM
                     LIPNVDRATFNQMIKELESSLIENSETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVL
                     KRGVYTIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQAAQPQVQNSKEKEKSEEEKN
                     HSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN"
     gene            23471..23847
                     /gene="tnpA"
                     /locus_tag="ACL8AS_001296"
                     /pseudo
     CDS             23471..23847
                     /gene="tnpA"
                     /locus_tag="ACL8AS_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206386.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
     gene            24029..24091
                     /locus_tag="ACL8AS_001297"
                     /pseudo
     CDS             24029..24091
                     /locus_tag="ACL8AS_001297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006596946.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
     gene            complement(24235..24864)
                     /locus_tag="ACL8AS_001298"
     CDS             complement(24235..24864)
                     /locus_tag="ACL8AS_001298"
                     /EC_number="4.1.2.14"
                     /EC_number="4.1.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 2-keto-4-hydroxyglutarate
                     aldolase/2-keto-3-deoxy-6-phosphogluconate aldolase"
                     /protein_id="HGS1229150.1"
                     /translation="MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEI
                     AYTNQYAGQIIKELVDLYQDDQSVCIGAGTVLDAVTARDAILAGANYVVSPSFHAETA
                     KMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSTLSPAYISAVKAPIPQVSVMV
                     TGGVGLNNIPQWFAAGADAVGIGGELNKLASQGNFDRISEIAQQYITLR"
     gene            complement(24874..25875)
                     /locus_tag="ACL8AS_001299"
     CDS             complement(24874..25875)
                     /locus_tag="ACL8AS_001299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HGS1229151.1"
                     /translation="MTKILLFGEPLIRISPLDATSIGDHVASSTYFGGSEINIACNLQ
                     ALGISTKVFTALPANEIGDRFLTFLKQHQIDTSSICRLGDRIGLYYLENGFGCRQSEV
                     FYDRKHTSISQIRPNMLDMDSLFQGISHFHFSGITIAIGQEVRAILLLLLEEAKRRGI
                     VVSMDLNLRTKMISVLEAKYEFSKFARFTDYCFGIDPLMIDDQNLEMFPRDSASLEEV
                     ENRMRLLKEAYGFKAIFHTLRSSDEQDKNVYQAYALEERFEESVQLKTAVYQRIGSGD
                     AFISGALYQLLHHSSLKTTIDFAVASATLKCTLPGDHLSTSSTSIENLLANAQDIIR"
     gene            complement(25906..26547)
                     /locus_tag="ACL8AS_001300"
     CDS             complement(25906..26547)
                     /locus_tag="ACL8AS_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="HGS1229152.1"
                     /translation="MKIALINENSQASKNHIIYDSLKEATDKKGYQLFNYGMRGEEGE
                     SQLTYVQNGLMAAILLNTKAVDFVVTGCGTGVGAMLALNSFPGVVCGLAVDPTDAYLY
                     SQINGGNALSIPYAKGFGWGAELTLKLMFERLFAEEMGGGYPRERVIPEQRNARILNE
                     VKQITHNDLMTILKTIDQDFLKDTISGKYFQEYFFENCQDDEVAAYLKEVLAK"
     gene            complement(26566..27381)
                     /locus_tag="ACL8AS_001301"
     CDS             complement(26566..27381)
                     /locus_tag="ACL8AS_001301"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="HGS1229153.1"
                     /translation="MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVF
                     NDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIKQEVGVIDILVNNAGI
                     IRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRET
                     VSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFD
                     QFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE"
BASE COUNT         8265 a         5119 c         6062 g         8026 t
ORIGIN      
        1 aaaaacactg ttttgaggtt gcagatagaa ctgacgaagt cagtaacata tatacggcaa
       61 ggcgacgttg acgcggtttg aagagatttt tgaagagtat gaaacgaaaa ggaggttggt
      121 cattgtacta gcctcctttt gatatgatat aatagttcta tgagattaga taaattttta
      181 gttgcctgtg cggtgggaag tcggactgag gtcaaaaact tgctcaaggc tgggcgcgtg
      241 actgtaaatg gtaaaaaaga aaaatcagct aaattgcaga ttgatgaaaa aatagatgag
      301 attcgctttg atgggcaagt gttggagtat gaagagtttg tctactacat gatgaacaag
      361 cccaaaggag ttatctcagc gactgaggat cccaagcaca gaaccgttct ggacttgttg
      421 gatgacttgg cgcggagtaa ggaagttttt ccagtaggac gcttggatat tgacacgcat
      481 ggtcttttgc tcttgaccaa taatggtcag ctggctcatg ttcttctttc gcccaagcgt
      541 catgtggaca agacttatca ggctcaggtc aagggaatta tgacccaaga agatgtggag
      601 acatttatca agggcattcc gctcaaagac tttacctgtc agcccgctag actggagatt
      661 ctttccacag atgcagaaaa gaatcagagc caaatccgtg tgaccattgc agaagggaag
      721 tttcatcaga tcaagcgtat ggtgggctac tgtggcaagg aagtggtgga cttgcaacga
      781 ttgactatgg gaactttagt attagatgag aacctggaac gaggggaatg gcgtcgcttg
      841 accaaggaag aattagaaat tctccgcgct aatattattt aatttagttt aatactcaat
      901 gaaaatcaaa gagcaaacta ggaaactagc cgcaggctgt acttgagtac ggcaaggcga
      961 cgttgacgtg gtttgaagag attttcgaag agtataaatt cgaaaaaggt gagggacaat
     1021 gtcctcgcct tttatgtttt ttagttgctt cctttgtgaa aagagttata atagactgta
     1081 gaataaaagg aggaatctat gaacgcgatt caagaatcat ttactgataa actatttgcc
     1141 aactatgaag caaatgtaaa ataccaagcg attgaaaatg ctgccagcca caacggaatt
     1201 tttgcagctc tggaatgtcg ccaaagccat gtagacaaca cacctgtttt ctcattggat
     1261 ttaaccaagg acaaggtcac taaccagaaa gcgtctggtc gttgctggat gtttgcggct
     1321 ctcaacacct tccgccacaa actcatctcg caatacaaat tggagaactt tgagttgtca
     1381 caagcccaca ctttcttctg ggataagtat gagaaatcaa actggttctt ggagcaagtc
     1441 attgcgactt cagaccaaga attgactagc cgcaaggtta gcttcttact ccaaacacct
     1501 caacaagatg gcggtcaatg ggatatggtc gtttccctct ttgaaaaata cggtgtcgtg
     1561 cctaagtcag tttatcctga gtctgtttca tctagcagca gtcgtgagct aaatgcgatc
     1621 cttaataaat tgcttcgtca agatgctcaa atcttgcgtg atttgcttgt ttctggtgca
     1681 gatcaagcga ctgttcaagc taagaaagaa gacctcttgc aagaaatctt taactttctt
     1741 gctatgtcat taggacttcc accacgcaag tttgactttg cttatcgcga taaagataac
     1801 aactataaaa gtgaaaaagg aatcacacca caagagtttt acaagaaata tgtcaatctt
     1861 cctttagaag actacgtttc tgttatcaat gctccaactg ctgataaacc ttacggaaaa
     1921 tcttacacag ttgagatgtt ggggaatgtg gttggtagcc gtgcagttcg ctacatcaac
     1981 gttccaatgg agcgcttgaa agaattggcg attgcccaaa tgcaagcagg tgagactgtt
     2041 tggtttggtt ctgatgtcgg ccagctcagc aaccgtaagg ctggcatcct tgcgacagat
     2101 gtttatgact ttgaatcaag catggacatt aaacttactc aagacaaggc tggacgtttg
     2161 gactatagcg aaagcttgat gacccacgcc atggtcttga caggtgttga cttggacgaa
     2221 aatggtaaat caaccaagtg gaaggttgaa aactcatggg gagaaaaggt cggtacagat
     2281 ggttactttg ttgcctcaga cgcttggatg gacgaataca cataccaaat cgttgttcgt
     2341 aaggaattgc tgacagcaga agaacaagct gcctatggag cagaaccaat cgtacttgca
     2401 ccatgggatc caatgggagc cttggctgaa taaaagcata gaaaaaagga atcagatttt
     2461 agaacctggt tcctttttag ttgcttgatt acatgatgtg aagaacatgt gccacaatac
     2521 ccactgcgaa gagggcaagg ataatagtga ttggagatac ttttttctta agtaagtaca
     2581 tgcaaagtaa agtaaggagt agtcctgata atccaggaat caacatatcc aagttttgtt
     2641 ggaaagtagt aactttttca ggagtttgag acaatccttg tcctacttgt gcgaatgctt
     2701 cttggatacc tttagaccct tctggcaatt tatcccaatg gatataagcc ttttcatcta
     2761 gttgaacttt agaaacatcg aaagcaaatt taatatttac ccagcgttga acaaggacag
     2821 caagaatgaa catcccaagg atagaagctc ctttagtgat atcttgaagg ataccaccag
     2881 acatatcttt agtgatttct gatccagcct tgtatccaat ctcttgaaca taccacaaga
     2941 atgacatacg aatcaagttc catgcaacaa agaagaggag tggacccaag atattgccag
     3001 taagggcaag tgaagcaccg agagatccaa ggattgggcg tactgtaaac cagaatactg
     3061 ggtcaccgat accagcaaga ggtcccatca taccgatttt aaccccttgg atagcagcgt
     3121 catcgatttc cacaccgtta gcacgttctt cttcaagcgc aagagtaacc cccatgactg
     3181 gagcagctac gtatggatga gtgttgaaga actcaaggtg acgctcaaga gcagcgattt
     3241 gatcttcttt tttagtatag agttttttga tagctggaat gagtgtataa gcccagccca
     3301 agttttgcat ccgttcaaag ttccaagacc cttgtaagaa ggttgaacgc caccaaactt
     3361 ttttacgatc tgatttagtt aattgaagtt tttcagtcat gatgttttca gtcctttctt
     3421 atcttaatag tcttctagga tatcgccgat tgggtcgtta gaagttgcgg ctcctccgcc
     3481 accatttcca ccagttttag aaaggtgaag gtagataaga gcgatagcaa caccgatagc
     3541 accgaatccg attagagtaa tatctgacac agcagcgaga acgaaaccaa gagcgaagaa
     3601 tggccatact tcacgagttg ccatcatgtt gataaccatg gcgtaaccaa cggcaacgac
     3661 cataccacca ccgatagcca taccatcttt gagccagtct ggcatggcac taaggatact
     3721 ttgtacagtt tcagttggta ccataaggag aagagctgca ggaagcgcga tacgaagtcc
     3781 ttggaaaagt agcgcaatga aatgagcacg ctccacagcg ccgaagtcac cttttttagc
     3841 ggcagcatca gcagtgtgaa ccaatccaac tgaaattgta cgaacaatca tagttaagaa
     3901 tagaccagct acggcaagag ggatagcaac cgcttgggca acaccgatac cagtcttggt
     3961 aaagtcacca ccaagaacca tgataatggc agcagcgaca gaagcaagtg cagcatcagg
     4021 agcgatagca gcaccgatat ttgaccaacc aagggcaatc atttgaagcg atccaccgag
     4081 gataatccct gcttccaagt gacctgttac aagcccaata agggtacagg ctacaagtgg
     4141 ttggtgaaat tggaactggt cgaggatgcc ttcaagacct gcaaagaagg ctacaacgac
     4201 tactaaaacc atagaaataa tagacatgtt taaaatcctt tcataaataa tggcttattt
     4261 gacattggct ttgttaatca agtcaaacaa atctttttta gaatcatttg gtactttacg
     4321 gacatcaaat tcaacaccca agtcacgcat tttttcaaat gtagcaacat cttctttgtc
     4381 catagacaaa acggtattga ccaatgtttt acctgttgag tgagccatag aaccaacgtt
     4441 aagagtcttg attggcacgc cgccttcgat ggcacgaagg gcatcttgag gtgtttcaaa
     4501 caagataagg gcatgtgttt ctccaaaacg tgggtctttt gaaatctcaa tcagtttttg
     4561 aattggaacc acgttagcct tgacattacc tggagctgct tgtttaatca attctttacg
     4621 aaggtcgtct ttagccacgt tatctgaagc aacaatgata cgatttgctt ttgaatctgg
     4681 agtccaagca gttgcaacct gaccgtgaag tagacgtgtg tcaagacggg caagattgat
     4741 tttcaattta ccgtctccga taacagttcc ttctgggata gcagtttggg caactggagc
     4801 agctgcagcg cttgcaactt cttcaactgg atttagctct tctggaagag ctttgatgcc
     4861 atctttggct tctttaatga tattagcagc gactttttct acacctgcag cagcgtccat
     4921 gaggcgctct gtgtaggctt gaatcaacat cggtaagtta agtcctgtga tgatggcaaa
     4981 cttacgctca ggattttctc ccatcacgcg actagcttgg ttaaatggag aaccactcca
     5041 aaggtcagcc aaaactagaa cctcatcttc tgcgtcaaat gcagcaacag cgttattaaa
     5101 cttagcgtat agatcatcag gaccttcatt tggcataaag gtcacaactt gaaccttttc
     5161 ttgttcacca aagatcatag atcctgactg atgaataccc gcagcaaatt cgccgtggct
     5221 cgcaataatg attccgatac tcattattgt cattcctcct tttttgtttt agttttcatt
     5281 taagaaaact ttaagactgt ttaagtataa accgttttca taaaaaaagc aactatttat
     5341 cataaaaaat taaaaaattt ttatttttgt atgttgatat gttgagtttt tgaggagtaa
     5401 tcttgaattc ttatttaaaa atttaatata aaaaagttgg aagaagcttc caacttttaa
     5461 aataggtttc tattagatta gtgggtgaag tcgagtacca tacgtccttg gatttgacct
     5521 ttttccattt cgtcgaaaat ggcaacagca tcttctactg gacgtttttg aacaactggg
     5581 gctaccagac cttctgcacc aaattggaag gcttcttcta agtctttacg agttccgaca
     5641 agagaaccga tgacttggat tccatcgagg actgttttaa cgatgctgag ttccatcatt
     5701 tcagaaggaa gaccaacagc gacgacgcga ccaccagcac gaacggagtc aacagcctgg
     5761 ttgaaggcaa ctttagacac agcagttacg acagctgaat gagctcctcc atcagttttt
     5821 tctttgatga gtccagctac atcttcaact tcgaggccgt taatcacaat gtcagcgcct
     5881 acttcttttg caagggcaag tttgtcattg ttgatatcga ctgcgataac atgagcattg
     5941 aatacttttt tagcgtattg aacagcgagg ttaccaagtc caccagcacc gtaaagaaca
     6001 acccattggc ctggttcaac ttttgcttct ttgatagctt tataggttgt tactccagca
     6061 catgtgatag aagaagcttg ggctggatca agtccgtcag gaaccttgac agcatagtca
     6121 gcagttacga tacattgttc agccatacca ccgtctactg agtagccagc atttttcact
     6181 gtacggcaaa gggtttcgcg accagttgta cagtattcgc aagtgccaca tccttcaaag
     6241 aaccaagcaa cgctgacgcg gtcaccgact ttaaggcttt tcacatctgg agcaatctct
     6301 ttaacgatac cgataccttc gtgcccaaga acacgtcctg ggacttgacc aaagtcacca
     6361 tgagcaacgt ggaggtcggt gtggcaaacg ccacagtatt caacttctac aagtgcttcc
     6421 ccagtttcaa gtggacggag tactttttct tcaatagcaa caccagtgct ttctggattt
     6481 acaacaacag ctttcatagc tatcctcctt gatattgacc gagaacaggg acaacgggac
     6541 tggattgatt ttttgtcaac agagtcgagt gtgacgagct ctcttgtatt tatatgtgaa
     6601 gtatatcaca aaagaaagcc ttttccaagg ttttggagac aaaaagtaga acaatcgatt
     6661 aactggttga tgagactgtg aaaagagcac aaagaccagc ttgcaagctg gtcatactct
     6721 tcgaaaatct cttcaaacca cgtcagcttc atctacaacc tcaaagcagt gctttgagca
     6781 acctacggct agcttcctag tttgctcttt gattctcatt gagtatcagt ataggttata
     6841 agaataagtc ttgtagggtt ttggcaaccc catcttggtc gttggtaagg gaaatttgct
     6901 catctgcata agggagtagc tctggattgg catttttcat ggcataaccc ttcccagcaa
     6961 aagcgagcat ttcggtatca ttgtgttcat ctccaaaggc aatcaaatct tttttgtcac
     7021 gattcattat cttgagcaag tagtccaaag caaaggcctt gttgacacct tttggggtac
     7081 attcaaggat attgagcgga cctccccagg tattgataga aagttgatgc tggtagaagg
     7141 cgttcatgtc ttttgccaag gcatatttgt cactggctct ggtctgcaag aggatacagt
     7201 tagggtcctt ggtcaccaat tcaggctgga attgatcttc aggctggaaa gcttctacac
     7261 caaatagttt gggattggca atttcttcat tgggatttgt aatgtagaat tttttacgat
     7321 attctccagc gataaaatcg gcttgaatgt cctctgaacg ttgaaccata tctagcagat
     7381 attttttgtc tacagtcaaa cacttttcaa aatcccaaac ttggtctggt aaatgagtaa
     7441 gggatccgtt gaagttaatc ataggagtgt ctaagcccag ttcacggtaa aaatcttttg
     7501 acatacggta agggcgacct gtcgtaataa taacctgatg gcctttttca gcaacttttt
     7561 tgatggtttt tttggtaaag tcagaaattt gactgtctga gttgagcagg gttccatcca
     7621 ggtcaactgc aataattttt ttcgtcatat ggacctttct agtgtgtttt cagataagat
     7681 gtcttctatt ataacagaaa gcaggcagaa aagcagattc caaacaaaaa atgaaattgg
     7741 attaatttct taaacaaatc aaacaaagac attgaaaaag tgaatgataa atgatataat
     7801 tctattattg ttcgtaaaaa ttaaaaggag attgatgatg gacaaattat ttaaactaaa
     7861 agagaacggt acagacgttc gtacagaggt tctcgctggt ttaacaactt tctttgcaat
     7921 gagctatatt ctctttgtaa acccacaaat actttcacaa acaggaatgc ctgctcaggg
     7981 cgtcttccta gcgacgatta ttggtgcagt agcgggtacc ttgatgatgg ctttttatgc
     8041 taacttacct tatgcccaag cgccaggtat gggactcaat gccttcttta cctttacagt
     8101 tgtattcggg cttggttatt cttggcaaga agccctagct atggtcttca tctgtgggat
     8161 tatttcattg attattacct tgacaaatgt tcgtaaaatg atcattgaat cgattcccaa
     8221 tgctcttcgc tcagctattt cagctggtat cggtgtcttc cttgcctatg tagggattaa
     8281 gaatgctgga cttttgaaat tcacgattga tccaggcaac tatactgttg taggagaagg
     8341 ggctgacaaa gctcaagcaa cgattgcagc aaactcttca gcagttccag gattggtcag
     8401 ctttaataat ccagctgttt tagtggctct tgcaggactt gccattacta tcttctttgt
     8461 catcaaaggg attaaagggg gaattattct ctctatcttg acaacaactg ttcttgctat
     8521 tgcagttggt ttggttgatt tgtctagtat cgattttgct aataaccatg ttggtgcagc
     8581 ttttgaagat ttgaagacaa tctttggtgc agctcttggt tcagaaggtt taggagcttt
     8641 ggtttcagat acagctcgct tgcctgaaac tctgatggcc attcttgcct tctcattgac
     8701 agatattttt gacacaattg gtaccttgat cggtacaggt gaaaaagttg gtattgtagc
     8761 gacaaatggt gaaaatcacc aatcagccaa attggataag gctctttact ctgatttgat
     8821 tggaacgaca gtcggtgcca ttgcaggtac ttcaaacgta acgacttatg ttgagtctgc
     8881 tgctggtatc ggtgcaggtg gacgtactgg tttgacagcc ttggttgtag ctatctgttt
     8941 tgcgatttca agcttcttta gcccacttct agcgatcgta ccaacagcgg ctacagctcc
     9001 aatcttgatt atcgttggga ttatgatgct tggtagcttg aaaaatatcc attgggatga
     9061 tatgtctgaa gcagttcctg ccttcttcac atctatcttt atgggattca gctactctat
     9121 cactcaaggg attgcagttg gtttcttgac ttacactttg actaagcttg tcaaaggtca
     9181 agttaaaaat gttcatgcca tgatttggat tttggatgcc ttgtttatcc ttaactacat
     9241 cagcatggcc ttataataga atgacccagg gggatttccc ccctttttta atacaaagga
     9301 gataggtgat gaaagagaaa aatatgtgga aagaattgtt gaatcgtgca ggctggattt
     9361 tggtcttttt acttgccgtc cttttatatc aggttcccct agtggttacc tctattttga
     9421 ctttaaaaga agtagccctg ctacagtcag ggctgatagt tgctggcctt tcaattgtgg
     9481 ttctggtgtt atttattatt ggagctcgta aaacgcaatt ggcaagtttt aatttttctt
     9541 tttttagaac taaggatttg gcacgtttgg gcttgagtta tttagtcatt atctgttcaa
     9601 atatacttgg ttctatcttg ttgcaactgt caaatgagac gacaacagct aaccagtctc
     9661 agattaacga tatggttcag aatagttctc tgatttctag cttcttcttg ctagccttgc
     9721 ttgctccaat ttgtgaggaa atcttgtgcc gtgggattgt tcctaaaaag attttccgag
     9781 gcaaggagaa cttgggattt gtagtcggta cgattgtgtt tgctttattg catcaaccaa
     9841 gtaatttacc ttctttattg atttatggag gtatgtcgac agttctatct tggacggcct
     9901 acaagaccca acgtttggaa atgtcgatct tgcttcacat gattgttaat gggattgctt
     9961 tctgtttgtt ggctcttgtg gtgattatga gtcggacatt aggaatttct gtgtaaaagt
    10021 ttttatgtag gaaccgacct ctttctacta gggaaagatg aatgcaatcg tgtccatctt
    10081 tttcttttta tggtaaaata gaaaaataat atgatgaaaa tccttgaggg agtgaccgat
    10141 atgtcaagta aagccaatca tgcaaagaca gttatttgcg gaattatcaa tgtaacccca
    10201 gactcctttt cggacggtgg taaatttttt gctcttgagc aggcactcca gcaggctcgt
    10261 aaattgatag cagaaggagc cagtatgctc gatatcggcg gagaatcgac tcggccgggc
    10321 agtagctatg ttgagataga agaggaaatc cagcgtgttg ttccagtgat caaagcgatt
    10381 cgcaaggaaa gtgatgtcct catctctatt gatacttgga agagtcaagt agcagaggct
    10441 gctttggctg ctggtgccga tctagtcaat gatatcactg gtcttatggg tgatgagaaa
    10501 atggctcatg tggtagctga agcgagagcg caagtggtca tcatgtttaa tccagttatg
    10561 gcgcgacctc agcaccctag ctcgctcatc ttccctcatt ttggttttgg tcaagctttt
    10621 acagaggaag agttagctga ctttgaaaca ttgccaatcg aagaattgat ggaggctttc
    10681 tttgaacgag cactagcgag agcggcagaa gctggtattg caccagaaaa tatcctgttg
    10741 gatccaggaa ttggctttgg tctgaccaag aaagaaaatc tgcttctttt acgggacctg
    10801 gataaactac atcagaaggg ctatccaatc tttctcggag tgtcgcgcaa gcgatttgtc
    10861 atcaatatcc tagaggagaa tggttttgaa gtcaatcctg agacagagct tggtttccga
    10921 aatcgggaca cggcttcggc tcatgtaact agtatcgctg cgagacaggg tgtagaagtg
    10981 gtacgcgtgc atgacgtagc tagtcacagg atggcagttg aaattgcctc tgccattcgt
    11041 ctggctgatg aagcggaaaa tttagattta aaacaatata aataagatga aagaaattga
    11101 aaacaatcag tggattgcta actaccggac ggatcaaccg cattttggat tggaacgaat
    11161 ggtggaactg ttagctttgc gtggcaatcc ccatctcaaa ctcaaggtcc tccatatcgg
    11221 agggactaac ggcaagggct cgactattgc ttttttgaaa aagatgctag aaaagctagg
    11281 gctgagagtt ggcgtgttta gctcgcccta tctcattcat tacacagacc agattagcat
    11341 caatggggaa tcgatctcag aagcgaggct agaagctctc atggcagact atcagtcttt
    11401 gctggaggga gaagcggtcg ccaatttaca gggcacaacc gagtttgaga ttatcacagc
    11461 cctggcctat gactactttg cctcagagca agtagatgtg gccatcatgg aagttggcat
    11521 gggtggactt ttggatagta ccaatgtctg tcagcccatt ttgacaggaa ttacaactat
    11581 tggcttggat catgtggccc tacttggtga caccttggag gccatagcag agcagaaggc
    11641 aggtattatc aaacaaggga tgcccttggt aacagggcgt attgctccag aagccttgac
    11701 tgtgattgac cgcattgcgg aagagaaaga tgcgccgaga cttgcctacg ggacagatta
    11761 tcaggttcgt catcaagaaa gtgtggtgac aggggaagtc tttgactata caagtgctgt
    11821 cagacaaggt cgcttccaga ctagcctgct tggtttgtac caaatagaga atgctgggat
    11881 ggccatagct ttacttgata ctttttgtca agaagatggt cgagagctag caagcaatga
    11941 ctttcttggt caagccttgg aagaaacaag ttggccaggg cgtttggaaa tcgtgtcaag
    12001 agatcccttg atgattttgg atggagccca caatccccat gctatcaagg ccttgttggt
    12061 aaccttgcaa gaacgttttg cggatcatca taaggaaatc ctcttcactt gtatcaaaac
    12121 caaagccttg gaggatatgt tggacttgct gggagccatg ccagataccg agctcactct
    12181 aacacatttt gcggatagtc gggcgacgga tgaaagcgtg ctgaaagagg cagctaagtc
    12241 tagaaatctc agctaccaag attggcatga ttttctagag cagaatttga cagataaaaa
    12301 agaagagaaa caaacagtta ggattgtcac aggttccttg tatttcttga gccaagtgag
    12361 ggcctatctg atggagagga agaacgagaa tggatacaca aaagattgaa gcagctgtga
    12421 aaatgattat cgaggctgta ggagaggacg ctaatcgcga gggcttgcag gaaacacctg
    12481 ctcgtgtagc ccgtatgtat caagagattt tttcaggtct tggtcaaaca gcagaggaac
    12541 atttgtcaaa atcctttgaa attattgacg ataatatggt ggtagaaaag gatatctttt
    12601 tccataccat gtgtgaacac cacttcttgc cattttatgg tagagcgcac attgcctaca
    12661 ttccagatgg tcgtgtggca ggcttgtcta agctagcccg tacggttgaa gtttattcga
    12721 aaaaaccaca aattcaagaa cgtttgaata tcgaagtggc cgatgccttg atggactatc
    12781 taggtgctaa aggagccttt gttgtcattg aggcggaaca tatgtgtatg agtatgcgtg
    12841 gtgttagaaa accaggcact gcaaccttga cgacagtagc tcgtggtcta tttgaaacag
    12901 ataaggacct ccgcgaccaa gcttatcgtt taatggggct ataaaaagaa tccgcttcaa
    12961 gcggattttt ctagaaagga atcattatgg atcaactgca gattaaggat ttggaaatgt
    13021 ttgcctatca tggtcttttt cctagtgaga aagaattggg gcagaaattt gtcgtttcag
    13081 ccatcctatc ctatgatatg accaaggcag ctacagactt ggatttaaca gcctctgtcc
    13141 attacggaga attgtgtcag cagtggacga cttggtttca ggaaacgagt gaggatttga
    13201 ttgaaacggt agcctataaa ctggtggaac gtacctttga gtcttatcct cttgtccaag
    13261 aaatgaagtt ggaactgaaa aaaccttggg caccggtgca tttgtcacta gatacttgct
    13321 cggtaaccat tcatcgccgc aagcaacgag cctttatcgc cctaggaagc aatatgggag
    13381 ataagcaagc aaacttgaag caagccattg acaaactgcg agctcgtggc atccatattc
    13441 tcaaagagtc cagtgtctta gcgacggagc cttggggtgg agtggagcag gatagctttg
    13501 ccaatcaagt ggttgaggtg gaaacctggc taccagcaca agacttgtta gaaaccttgt
    13561 tagccattga gtcagagctg ggacgggtga gagaagtgca ttggggacct cgtttgattg
    13621 atttggactt gctctttgtg gaggaccaga tcctttatac agacgacctc atattgcctc
    13681 atccttacat agcggaacgc ctttttgtcc ttgagtcctt acaggaaatt gcgcctcatt
    13741 ttatccatcc gatattaaaa caaccgatcc gcaacttgta tgatgctttg aaaaaataga
    13801 aaaactctag ttttcagtta cttgcaactg aaggctagag tttttaaaat aggtcatttt
    13861 cttctgggag gaggatagtt tctctaccgt ccatgtctaa aaccagtact cttgggggat
    13921 aacgagggtc gaaaggatgg ttaaagtcaa aatcaatggc tgtagggagg tgttgacttg
    13981 aaaagtggaa ggtaatcttt ccttggttat taagcaattg aaactcgagt tcttcttcca
    14041 attcaaagac attttttaag aaatggtcga tgatatacca aaaagagtca atgatgtcat
    14101 caggcaagct ggtaacaatg ccaaaactag cagatcgcat gtgggtattg gtaaaagcca
    14161 tatctctgtc ccctttcttt tcccttatca tacagcaaat aggattaaaa atcaagaaaa
    14221 ggtgattttt tgaaaaggat tttagttaca gggagaaata gggaaaaaat tcctaaaaat
    14281 ctaccgaagt taataggtaa attcccaaat taacttgatt atataacttt cagttacttt
    14341 gagaagttac cgaaaaatat ttttcatatc tattgacttt taggggtaaa atttggtatg
    14401 atagtaggcg gtattgttta ccccatttga aaggccccgg aaccttccaa atacttttcg
    14461 atgggaagga acacccatca ccgtaaacaa aaatcgaact atatatagga gaaatcatga
    14521 acaaaacaac atttatggct aaaccaggcc aagttgaacg taaatggtac gtagttgacg
    14581 caactgatgt accacttgga cgtctttctg cagtagttgc tagcgtactt cgcggaaaaa
    14641 acaaaccaac atttacacca cacactgata caggtgactt cgtgattgtt atcaatgctg
    14701 aaaaagttaa attgactggt aaaaaagcaa ctgataaaat ctactacact cactcaaacc
    14761 acccaggtgg attgaaacaa atctctgcag gtgaacttcg ttctaaaaat gcagtacgtt
    14821 tgattgagaa atcagttaaa ggtatgcttc cacacaatac acttggacgc gctcaaggta
    14881 tgaagttgaa agtatttgtt ggagctgagc acactcacgc tgcacaacaa ccagaagttc
    14941 ttgacatttc aggacttatc taaggaaagg aacaataaag tatgtcacaa gcacaatatg
    15001 caggtactgg acgtcgtaaa aacgctgttg cacgcgttcg ccttgttcca ggaactggta
    15061 aaatcactgt taacaaaaaa gatgttgaag agtacatccc acacgctgac cttcgtcttg
    15121 tcatcaacca accattcgca gttacttcaa ctgtaggttc atacgacgtt ttcgttaacg
    15181 ttgtaggtgg tggatacgct ggtcaatcag gagctatccg tcacggtatc gctcgtgccc
    15241 ttcttcaagt agacccagac ttccgcgatt cattgaaacg cgcaggactt cttacacgtg
    15301 actcacgtaa agttgaacgt aagaaaccag gtcttaagaa agctcgtaaa gcatcacaat
    15361 ttagtaaacg ttaattcgaa agaattacta tacttataca gagcaccttt cggggtgttc
    15421 ttttttatac tttcttacta aattggtgca attgacacag ttgttgcgac tttagtcgct
    15481 tacaaatgtg gctgcaacct gacaaggtca gttgcctcaa aacgttaatc aatacaatta
    15541 tatcaacgtt tcaaagcact caagagttta cctcatgggt gcttttttta tgttttttga
    15601 aaaagttcac ctcaaagttt accttatttt caccttattg ttttagagac tgtaaggcaa
    15661 attcaccgac ggccataggg actacattag aagtattgac ataaatctgt gttgtacctg
    15721 tgtcgctatg tattagagct tcagaaatgg tttctaagct cattcctgct tgtttagcga
    15781 gcgttgctcc ggtatgacgt agtttgtgtg gcgtagcgtg tgtaagctct gggtgtcgtt
    15841 ttctgatagt tttcatctta ttattgagat agtcagaatg taaaggttta ttgatattgc
    15901 ctttggtatc tatgtaagta aagatgaatt gttctggatt actgatgata ccaaactttg
    15961 ccagttcata tttttgttgt tttttccatg aagtcagaag ttgaagtaag tcattagaaa
    16021 tagagaaaat gggaaatgtt tccacaataa aacgcatatt atcagatggt taatgcgttt
    16081 tatatttggg tttgaggttt ataaaatagg ataagcgtgc tgaaaactta gatatgacaa
    16141 acaaaataaa atttttaaaa gctacagaga aacatggtat aatgtatcta aaggaggtag
    16201 catatgtcct tagatataga taaagaaaag atgacaatca tgggaatagc ttttgaaaac
    16261 cgatccgttt ttaagagtgt ttggtatgct ttaagtacaa atatgattga aggatggcga
    16321 cctacggtta gtgatgttga aaaattacga gatgaagctc ttgctctggg gatgacttaa
    16381 tgaagcgcaa ctgttatgaa tcttatgact atgttgattc ggataattta tataccgatc
    16441 cgggttcttc agttctaaga aataagcagg aaggaaaaaa gcacgcgagc ttgaatatcg
    16501 tatgattgct agtaagagtt tgaaattatt tatcaatcct atcttagtta atagtttaaa
    16561 agtagtttgt ttcacaactg cataagctta gaaaagttga aaagtgataa ctctttaata
    16621 aactcttggt ttgttaaaag atattttgtc cactacattt tttcaattga ctattatttg
    16681 tcatagatat aacagataga acattgcatt cagaataatg aaaaacgcat caaaaatggt
    16741 gcgttctgtt tttatgctac cataaaagga gggaaacaaa ttgaaaattt ttaagggaga
    16801 gttttatcgc atctctgtat taacagacaa gctagtaagg ttagaatact ctaaaactgg
    16861 cagttttgag gatagaacta cacaacttat ctataataga gattttggcc aagtttcgtt
    16921 agattatatc gagacatcaa acgtactaga tattatgacg gactattttc atctgcactt
    16981 taataaagga gaatttaacg ccgaaaattt atttatagaa ttaaaaggaa attttgccgt
    17041 atatggtagt cgctggtatt ttggtgaatc gattgaaacg ttaaaaggaa cagctcggac
    17101 tctggataag gcagatggag caatcccatt agaagatgga attattagtc gaaatggtat
    17161 agccttattg gatgattctc aaggatttat ttgggatgaa cagtctggtt atattgagag
    17221 agaaaatcaa attgacctct atttctttgc ctatgggcat gattatagag gagcaatcag
    17281 agacttttac catttgactg gttcaacacc cttgttacca agatatgctt tagggaattg
    17341 gtggagtaga tattggcctt atacgtcgga tgaatacttg gatttaatag acagatttga
    17401 aacagagaaa attccattat ctatcggtgt gttagatatg gattggcata taactgacat
    17461 tccagctcgt tttggaagtg gctggacagg atatagttgg aataaaaact taatacctaa
    17521 tccagaacag ttattgcaac aacttcatga tagaaagtta aaactctctt taaatgtcca
    17581 tcctgctgat gggatacggg cttatgaaga agcttatcct caagtcgcca aacgattagg
    17641 gttaaatgta gaactagaag aacctgccat ttttgatttt tttaatccct cttttaggga
    17701 agcctacttt aaagatgttc attatgagct agaaaagcag ggagtagatt tttggtggat
    17761 tgactggcaa caagggactc aaggcatatt ggatccacta tggcttttaa accattatca
    17821 ttatcaggat agttgtaaaa atgcagaagg tggtttgatt ttattaagat atgcaggtcc
    17881 tggtagccac cgctaccctg ttggtttttc aggggacact attattagtt ggaattcctt
    17941 aagatttcaa ccttatttta cagcgacagc atctaatatc ggttatagtt ggtggagcca
    18001 tgatatcggt gggcacatgc tgggggatta tgacgaagag ctgcaaacta gatggctaca
    18061 gtttggtgtt tttagtccga tcactcgatt acatagttct agaagtcctt ttaatagtaa
    18121 agaaccttgg tttttttcag aaacaacatc taagattatg aagaaatacc ttcgtttgag
    18181 gcatcagatg attccatatc tatacactat gaatgtaaag acacacgagg aaggtgcccc
    18241 attaatcagc ccaatgtatt atttctaccc agagaatgat gagagctata atgttccaaa
    18301 ccaatacttt tttggaacag aactaatggt ggctcccatt gtagaaaaga tggacttggc
    18361 attccaatct gcaaaagtgg atgtatggtt ccctgaaggt gaatggtatg acttcttttc
    18421 agagaaaaaa tatacaggtg gtgtgaagtt gagtgtttat agagacattt cgactatacc
    18481 tgtgtttgca aaaagtggtg cgatcattcc cttggttggt tctgagatag atatgggtgt
    18541 tgatttacct gaagttgtag attggtatgt attcccaggc aaacaacatt cttttgaaat
    18601 gcttgaagat caaaatggtc aaagatataa aacaagatta tcaatcgatt gggaaatggg
    18661 gatggtagag ttaacattac aaggagattc tagtatcgtt ccaagcaata gaaggcatag
    18721 aattcatttt aaaggaacga atgtgtctat aattgaatta ccaaataaga atgatacagc
    18781 tagatttgaa tgtaaagata ataaaacaat atctttaaat gatgaagttt ttagactact
    18841 aaagacagct tctcttccat atgaattaaa agatagattg ttaaatcaat tcatcaatgc
    18901 gaaaaactct catgacttaa tgaatatctt gcatcatcag gataaggaat tgagagggcg
    18961 tttgttggaa atgatattta ctagccaaaa ctaattgata taattagaaa gtcatttgtt
    19021 tagtgtatat gaagattctg tatggtattc gttatcactg gtcacattga aaatgtgaaa
    19081 taagcaccta caacatagac tttacaacac ttcatgtttc atatcatggg gtgtttttct
    19141 atttaagtca aagccaatca aaaaatctca ctattcatca ggttaaagga aacctaatca
    19201 tagtgagatt gtgaattata gtagagtttg tatcgcctct tcaatttgtt ttgggtctgt
    19261 ttttgaagaa aagcgttcaa agacttgccc atctcgaccg atgagaaact tagcgaaatt
    19321 ccattcgact cgttttccta gtgggccgga tttctggtct tttaaccaga catagagagg
    19381 gtctgcttcc ttaccgttga ccttaatctt ggcaaaacgt gggaaggtgg tttgaaaatg
    19441 taggctacag aaggcgttga tttcctctgc gctgccgggt gcttgtccca taaactgatt
    19501 gcaagggaaa tccaatattt caaagccctg atcttgatag cgttcataga gttcttgaag
    19561 tccctggtac tggggcgtta aaccacatcc agtagcagtg ttgacaatca agagaacttt
    19621 gccacgatag ctatccaagg gagttgcttg gttgttttgg ttcaaaacgg aaaaatcata
    19681 aagtgaagtc atgagggcct cttttctttt tctacattgt aacagttttt acttttttcg
    19741 tcgagtcgga tggaagatat tgttgaagaa taagccctca atatgataga aaccgtttac
    19801 aaataacttt aaaaatggta taatttaatt aaaccggttt acttagttgc tataaatctc
    19861 taatttgaga tttagttcct attgatttta caatatgttt attggagtgt atacatgcaa
    19921 acaaaaacaa agaagctcat tgtgagtttg tcttcacttg ttttatcagg atttttatta
    19981 aaccattata tgacagttgg agcggaagaa acgactacga ataccattca gcaaagccag
    20041 aaggaagttc agtatcagca aagggataca aaaaatttag ttgaaaatgg tgattttggt
    20101 cagacggagg acggaagcag tccgtggaca ggaagcaaag ctcaggggtg gtcagcttgg
    20161 gtagaccaga agaatagttc tgcagatgcc tcaactcgag tcattgaggc taaggatggg
    20221 gctatcacta tctcaagccc tgagaaatta agggcagcgg ttcaccgtat ggttcctatt
    20281 gaagctaaga aaaagtataa actgcgtttc aagattaaaa cagatcataa agtcgggatt
    20341 gccaaagttc gtatcattga ggaaagtggt aaggacaagc gattgtggaa ttctgcaacg
    20401 acgtcaggaa caaaggactg gcagaccatt gaagcagact atagcccgac tttagatgtt
    20461 gataaaatca agctggagtt attctatgaa acaggaactg ggactgtttc ctttaaggat
    20521 attgagctgg tagaggtagc agaccagctt tctgaggatt ctcaaacaga taaacagctt
    20581 gaggaaaaga ttgatttacc aattggaaaa aaacatgttt tttctcttgc ggactatact
    20641 tataaggtag aaaatcctga cgttgcttca gtcaaaaatg gaattttaga acctcttaag
    20701 gaagggacaa ccaatgtcat tgtcagtaaa gatggcaagg aagtgaaaaa gattcctttg
    20761 aagattctag cctctgttaa ggatgcatac acagcccgtt tggatgactg gaatggcatc
    20821 atcgctggga atcaatacta tgattctaaa aatgaacaga tggccaaatt aaaccaggaa
    20881 ttggaaggaa aggtagctga tagcctatct agtatttcaa gtcaggcgga ccgcacctat
    20941 ttgtgggaaa aattttcaaa ttataaaatg tctgcaaatc tgactgccac ttatcggaaa
    21001 ttggaggaga tggccaagca agtgaccaat ccttcttctc gttattatca agatgaaact
    21061 gtcgttcgaa cagtcaggga ttccatggaa tggctgcata aacatgtcta caatagtgaa
    21121 aagagcattg ttgggaactg gtgggattat gagatcggta cacctcgtgc catcaacaat
    21181 accttgtctc tgatgaaaga atacttctct gatgaggaaa ttaaaaaata tacagatgta
    21241 attgaaaaat ttgtaccaga ccccgaacat ttccgaaaga cgactgataa cccatttaag
    21301 gctctaggtg gaaacttagt tgatatggga agagtaaaag taatagctgg tttactgcgt
    21361 aaagatgatc aagaaatttc ttctaccatt cgctcgattg agcaagtgtt caagttggta
    21421 gaccaaggtg aaggttttta tcaagatgga tcctatatcg accacaccaa tgttgcctat
    21481 acgggtgctt atgggaatgt tttgattgat ggcctgtctc aactgttgcc agtcattcaa
    21541 aagaccaaga gtccaatcga taaagataaa atgcaaacca tgtaccactg gattgataaa
    21601 tcgtttgctc ctttgctggt gaatggagaa ctgatggata tgagtcgtgg acgctcgatc
    21661 agtcgtgcaa atagcgaggg gcacgtggcc gcagtagaag tactaagagg gattcaccga
    21721 atagcggata tgtctgaagg agaaaccaaa caacgtttgc agagtcttgt gaagaccatt
    21781 gttcaatcgg atagttatta tgatgtcttt aagaatttga agacttataa ggatatcagt
    21841 ttgatgcaat ccttgttaag tgatgcagga gtcgcaagtg ttccaagacc aagttaccta
    21901 tctgccttta acaagatgga taaaacagcc atgtacaatg cagagaaagg gtttggattt
    21961 ggcttgtcac tcttttccag tcgtaccttg aattacgaac acatgaacaa ggaaaataaa
    22021 cgtggttggt atacgagtga tgggatgttc tatctttaca atggcgattt gagtcactat
    22081 agcgatggct actggccaac agttaatcca tataagatgc ctggtacaac agagacggat
    22141 gctaagagag cggatagcga tacaggtaaa gttttaccgt ctgctttcgt tggaacgagc
    22201 aaactagatg atgccaatgc gacagcaacc atggatttca ccaactggaa tcaaacattg
    22261 actgctcata agagctggtt tatgctaaag gataagattg cctttttagg aagcaatatc
    22321 caaaacactt caacagatac tgctgcaact acaattgacc agagaaaact ggaatcaagt
    22381 aatccatata aagtctatgt caatgataaa gaagcctccc ttacagaaca agaaaaggat
    22441 tatcctgaaa cccaaagtgt ctttttagaa tcgttcgatt cgaaaaagaa tattggttac
    22501 tttttcttta agaagagttc aatcagtatg agtaaggctt tgcaaaaggg agcctggaag
    22561 gatatcaatg aaggacagtc agacaaggaa gttgaaaatg aatttcttac gattagtcag
    22621 gctcataagc aaaatggaga ttcttatggc tatatgctaa ttcctaacgt ggatcgtgcc
    22681 accttcaatc aaatgataaa agagttagaa agtagcctca tcgaaaatag cgaaaccctt
    22741 cagtctgttt atgatgctaa acaaggagtt tggggcattg tgaaatatga tgattctgtc
    22801 tctactattt ccaaccaatt ccaagttttg aaacgtggag tctataccat tcgaaaagaa
    22861 ggggatgaat ataagattgc ctactataat cctgaaaccc aggaatcagc tccagatcag
    22921 gaagtcttta aaaagctaga gcaagcagct cagccacaag tacagaattc aaaagaaaag
    22981 gaaaaatctg aagaggaaaa gaaccattcg gatcaaaaga atctccctca gacaggagaa
    23041 ggtcagtcaa tcttggcaag tctagggttc ttgctacttg gggcatttta tctattccgt
    23101 agaggaaaga acaactaatt tgttcatcat ctagatgaat tacatgaaac tgtggaaaat
    23161 agaaaaaatc cgaagaaggc caaatatctt cggatttttc ttttaaaaaa ggataagttg
    23221 atacttatcc ttttttactt cattattatg tgactatagc gttttgaaac tagaatagaa
    23281 cgttataact gctaaaagat ttctataaat tcatttgatt ttcctaatca atttgttcgt
    23341 atcctatttc actccactat ataagtccgt ctcgctccgt gaggtgcgcg tcgaaggtta
    23401 taccaaaaaa actccaaacg cgatacaata aaggtgttca atccaattgt aaagcgaaag
    23461 gagaaaaaat atggcacaaa agactcatag tttatcatac acaaagtgga tgtgttctat
    23521 catattgtgt tcacccctaa gtatagacga aaagtcatct ataatcaata tagaagtagt
    23581 ttaggcgaaa tatttcatcg cttgtgtagt tataaaggtg ttgaaatgat cgagggtcac
    23641 ttaatgccag accatgtaca catgttagtc agtattccgt cgaggctaag tgtttcaagt
    23701 tttatggggt atttaaaagg caaaagtgca ctcatgatgt ttgacaaaca cgccaatctc
    23761 aagtacaagt ttgggaatcg gaatttctgg gcggaaggtt attatgtaag tccagtaggg
    23821 cttaatgaag ccacaattaa gaaatatagt caagattaaa gaaattatcg agtggatgat
    23881 ttcttcacga gtatgaaaat ttgagaacta gtaaagtatg atatatagta aaatgaaata
    23941 agaacaggac aaaatcgatc aggacagtca aatcgatttt taacaatgtt ttagaagtag
    24001 aggtatacta ttccagtttc aatctactat agcactagat aaattgagtg taaaagaata
    24061 tgaggatccc tttagggata gtggtaagta ataccaaagt ctcttaaaga ggcaagtgac
    24121 gagtcaagag caataaggct tgaacaacgt gaaagccagc gtctttaggc gctggctggt
    24181 aatttgggct tatagctctg ggataaacca cccgtttgac gggtggttat gattttatct
    24241 gagtgtaata tactgttggg caatctcgct gatgcggtca aagttgcctt gggaagcgag
    24301 tttattgagt tcgccaccaa ttccaacggc atctgcacca gcagcgaacc attgagggat
    24361 gttgtttagg ccgactcctc cggttaccat tacggaaact tgtgggatcg gtgccttaac
    24421 tgcagagata tatgctggac tgagagtact acctgggaag agtttgatga tttcactacc
    24481 ggcttcaagt gcagtcgtga tctctgtgag ggtaatacag cctggaatgt acggtgtgct
    24541 gtagagattg cacattttcg cagtttcagc atggaaagat ggagaaacaa cgtaatttgc
    24601 tccagctaga atggcatctc tagcagttac ggcatcaagc acagtacctg caccgataca
    24661 aacactctga tcgtcctgat acaagtctac aagttccttg atgatttgtc ctgcatactg
    24721 attggtatag gcgatttcaa tagctttgat accgcccttg atacaagcaa tcgaggcttg
    24781 tagtccttct tcctttgtat ttcctcgaat gacagcgaca attttctgtt tttttagttc
    24841 aataatcgta tctgatttgg tcatgtaatt ctcctaacga atgatatctt gtgcatttgc
    24901 cagtaaattt tcaatactag ttgaggaagt ggagagatgg tctcctggaa gagtgcattt
    24961 gagagttgcg ctcgcaactg caaagtcaat ggtagttttt agggaggaat gatggagtag
    25021 ttggtaaagg gcaccagata taaaggcatc cccgctacca attcgttgat agactgcagt
    25081 ttttagttgg acagactctt caaatcgttc ttccagagca taggcttgat agacattttt
    25141 gtcttgctca tcactagatc ggagggtatg gaaaatggcc ttgaaaccat aggcttcttt
    25201 taaaagtcgc atgcgatttt ccacctcttc taggctagca ctgtctcttg ggaacatctc
    25261 tagattttgg tcatcaatca tgagaggatc aataccgaag caatagtcag taaaacgtgc
    25321 aaacttagaa aattcatact tggcttctag gactgaaatc atctttgttc tcagattgag
    25381 atccattgaa acgacaattc ctcggcgctt ggcttcttcc aagagtagga gaaggatcgc
    25441 acggacctct tgaccgatag ctatggtgat tccactaaaa tgaaaatggc taatcccctg
    25501 aaagagagaa tccatatcta gcatgtttgg ccgaatctgg ctgatactcg tatgcttacg
    25561 atcgtagaaa acttcacttt gacgacaacc aaagccgttc tccaaatagt agaggccgat
    25621 tcgatcgcca agccgacaga ttgaactggt atcgatttgg tgctgtttca agaatgtgag
    25681 aaaacgatct ccaatctcgt tggcagggag tgcggtaaag actttcgttg agatacccag
    25741 ggcttgcaaa ttacaagcga tgttaatttc tgatccgcca aaataagtcg aactggcaac
    25801 atgatcgccg atactggtgg catctaatgg tgagattcga attaatggtt cgccaaacag
    25861 taatattttc gtcatccatt agttcctttc tggtttagaa tagctttact tggctaatac
    25921 ttctttcaaa taagcagcga cttcatcatc ttggcagttt tcaaagaagt attcttggaa
    25981 gtatttgcca gagatggtgt ctttgaggaa gtcttggtcg attgttttaa ggatggtcat
    26041 caaatcattg tgggtgattt gtttcacctc gtttaagata cgagcgttac gttgttcagg
    26101 gattacacgt tctcttgggt agccaccgcc catttcttca gcaaataagc gttcaaacat
    26161 caatttgagg gtcagttctg ccccccagcc aaatcctttg gcataaggga tagacaaggc
    26221 gttaccacca ttgatttgag aataaaggta agcgtcagtt gggtccactg ctagaccaca
    26281 gacaacacca gggaagctgt ttaaagcaag catagcccct acacccgtac cacagccagt
    26341 aacaacaaag tcaactgcct ttgtatttaa aaggatggca gccattagtc cgttctgcac
    26401 ataagttaat tgactttctc cttcttctcc acgcatacca tagttaaata attggtagcc
    26461 ctttttatct gtcgcttctt ttagactatc gtaaataatg tgattcttgc tagcttgact
    26521 attttcattg attaatgcga ttttcataag atcttctttc tatttttact caggttgttt
    26581 tccgatgtag gctaagatac cgccatctac atataggatg tggccattga caaaattgct
    26641 ggcatcacta gcgagaaaga cagcagggcc catcaaatct tcaggatttc cccaacgtgc
    26701 agcaggtgtt tttgcaatga tgaactggtc aaatgggtgg cgagaaccat cttcttgcaa
    26761 ctcacgaaga ggtgctgttt gaggagtggc aatataacct ggtccaattc cgttacattg
    26821 gatattggct ccaccgtatt cagacgcaat gttgcgggtc aacattttca agcccccttt
    26881 agcagcagca taagcgctaa ctgtttcacg tcccagttcg ctcatcatcg aacaaatatt
    26941 gataatcttt ccatgccctt tctttatcat agaaggaata actgcctttg aaacgataaa
    27001 tggtgcgttt aagtcaatat cgatgacctt acggaaatca gcggcgctca tttcgcacat
    27061 tggaactcgg cggataatac cagcgttatt aacgaggatg tcaatgacac caacctcttg
    27121 tttgatttgc ttgaccatgg cttggatacc gtcctcgtct gtcacgtcac agacatatcc
    27181 atgggcttcg atgccaactt cacgataagc ttcaatccct ttattgacca gatcttgatt
    27241 gatatcgtta aagacaatag tagcgccggc ttcagcgtag gatttggcaa tagcaaatcc
    27301 aattccataa gaagcgccgg tgatgagagc aatttttcct tttaaagaaa actgctcaat
    27361 tgagaatgat gtatttgtca tttgatactt cctttcaaat ttgttaagac ttctctataa
    27421 ccaaattata ttctagtaaa ccggttttgt caataaataa atatttttat tt
//
LOCUS       DBERMM010000024        26749 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.024, whole genome shotgun sequence.
ACCESSION   DBERMM010000024 DBERMM010000000
VERSION     DBERMM010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 26749)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26749)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26749
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.024"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..115)
                     /locus_tag="ACL8AS_001302"
     CDS             complement(<1..115)
                     /locus_tag="ACL8AS_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136123.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase"
                     /protein_id="HGS1229154.1"
                     /translation="MSQSIVPVEIPQYCRFDSKKRNGILFNVRIANLKFTFF"
     gene            complement(340..1200)
                     /locus_tag="ACL8AS_001303"
     CDS             complement(340..1200)
                     /locus_tag="ACL8AS_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HGS1229155.1"
                     /translation="MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYV
                     RRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLG
                     GPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
                     MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAG
                     RGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVI
                     LTSQGEEGTY"
     gene            complement(1216..2493)
                     /gene="spxR"
                     /locus_tag="ACL8AS_001304"
     CDS             complement(1216..2493)
                     /gene="spxR"
                     /locus_tag="ACL8AS_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS-HotDog domain-containing transcription
                     factor SpxR"
                     /protein_id="HGS1229156.1"
                     /translation="MSKHQEILSYLEELPVGKRVSVRSISNHLGVSDGTAYRAIKEAE
                     NRGIVETRPRSGTIRVKSQKVAIERLTFAEIAEVTSSEVLAGQEGLEREFSKFSIGAM
                     TEQNILSYLHDGGLLIVGDRTRIQLLALENENAVLVTGGFQVHDDVLKLANQKGIPVL
                     RSKHDTFTVATMINKALSNVQIKTDILTVEKLYRPSHEYGFLRETDTVKDYLDLVRKN
                     RSSRFPVINQHQVVVGVVTMRDAGDKSPSTTIDKVMSRSLFLVGLSTNIANVSQRMIA
                     EDFEMVPVVRSNQTLLGVVTRRDVMEKMSRSQVSALPTFSEQIGQKLSYHHDEVVITV
                     EPFMLEKNGVLANGVLAEILTHMTQDLVVNSGRNLIIEQMLIYFLQAVQIDDILRIQA
                     RIIHHTRRSAIIDYDIYHGHQIVSKANVTVKIN"
     gene            complement(2486..3037)
                     /locus_tag="ACL8AS_001305"
     CDS             complement(2486..3037)
                     /locus_tag="ACL8AS_001305"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1229157.1"
                     /translation="MNIWTKLAMFSFFETDRLYLRPFFFSDSQDFREIASNPENLQFI
                     FPTQASLEESQYALANYFMKSPLGVWAICDQKNQQMIGSIKFEKLDEIKKEAELGYFL
                     RKDAWSQGFMTEVVRKICQLSFEEFGLKQLFIITHLENKASQRVALKSGFSLFRQFKG
                     SDRYTRKMRDYLEFRYVKGEFNE"
     gene            complement(3053..4312)
                     /locus_tag="ACL8AS_001306"
     CDS             complement(3053..4312)
                     /locus_tag="ACL8AS_001306"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA];
                     GO_process: GO:0019277 - UDP-N-acetylgalactosamine
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HGS1229158.1"
                     /translation="MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCV
                     PDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLL
                     GRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
                     DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIID
                     GVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMT
                     VSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVN
                     HVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITN
                     IEFILRGYSDIIEKLRNLGADIRLVED"
     gene            complement(5455..5613)
                     /locus_tag="ACL8AS_001307"
     CDS             complement(5455..5613)
                     /locus_tag="ACL8AS_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229159.1"
                     /translation="MGDKPISFRDADGNFVSAADVWNEKKLEELFNRLNPNRALRLAR
                     TKKENPSQ"
     gene            complement(5623..6933)
                     /gene="obgE"
                     /locus_tag="ACL8AS_001308"
     CDS             complement(5623..6933)
                     /gene="obgE"
                     /locus_tag="ACL8AS_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HGS1229160.1"
                     /translation="MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGG
                     NVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAET
                     GKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
                     ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGL
                     IEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLME
                     RPQIIVANKMDMPESQENLEDFKKKLAENYDEFEELPAIFPISGLTKQGLATLLDATA
                     ELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNF
                     DRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD"
     gene            complement(6997..7131)
                     /locus_tag="ACL8AS_001309"
     CDS             complement(6997..7131)
                     /locus_tag="ACL8AS_001309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HGS1229161.1"
                     /translation="MAFGDNGNRKKTMFEKITLFIVIIMLVASLLGIFATAIGALSNL
                     "
     gene            complement(7190..7366)
                     /locus_tag="ACL8AS_001310"
     CDS             complement(7190..7366)
                     /locus_tag="ACL8AS_001310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HGS1229162.1"
                     /translation="MRSGRDKKIAGVCAGVAHYLDMDPTIVQVIWGVLTCCYGAGIVA
                     YIILWIIAPVATDY"
     gene            complement(7397..8722)
                     /locus_tag="ACL8AS_001311"
     CDS             complement(7397..8722)
                     /locus_tag="ACL8AS_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HGS1229163.1"
                     /translation="MRIGLFTDTYFPQVSGVATSIRTLKTELEKQGHAVFIFTTTDKD
                     VNRYEDWQIIRIPSVPFFAFKDRRFAYRGFSKALEIAKQYQLDIIHTQTEFSLGLLGI
                     WIARELKIPVIHTYHTQYEDYVHYIAKGMLIRSSMVKYLVRGFLHDVDGVICPSEIVR
                     DLLSDYKVKVEKRVIPTGIELAKFERPEIKQENLKELRSKLGIQDGEKTLLSLSRISY
                     EKNIQAVLAAFADVLKEEDKVKLVVAGDGPYLNDLKEQAQNLEIQDSVIFTGMIAPSE
                     TALYYKAADFFISASTSETQGLTYLESLASGTPVIAHGNPYLNNLISDKMFGTLYYGE
                     HDLAGAILEALIATPDMNEHTLSEKLYEISAENFGKRVHEFYLDAIISNNFQKDLAKD
                     DTVSQRIFKTVLYLQQQVVAVPVKGSRRMLKASKTQLISMRDYWKDHEE"
     gene            complement(8738..9781)
                     /gene="cpoA"
                     /locus_tag="ACL8AS_001312"
     CDS             complement(8738..9781)
                     /gene="cpoA"
                     /locus_tag="ACL8AS_001312"
                     /EC_number="2.4.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosylglucosyldiacylglycerol synthase"
                     /protein_id="HGS1229164.1"
                     /translation="MEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVT
                     ENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVK
                     RYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLR
                     TDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYK
                     KIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRD
                     LDLYKVILEGNYRATAGREEMKEAILEYQANPAVLKDLKEKAKNISREYSEEHLLQIW
                     LDFYEKQAALGRK"
     gene            complement(9896..10225)
                     /locus_tag="ACL8AS_001313"
     CDS             complement(9896..10225)
                     /locus_tag="ACL8AS_001313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HGS1229165.1"
                     /translation="MAYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDG
                     DTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEVPEVTDTEVKLVWYPAWTVEKMSRYA
                     RIALGIK"
     gene            complement(10239..11348)
                     /gene="rpoD"
                     /locus_tag="ACL8AS_001314"
     CDS             complement(10239..11348)
                     /gene="rpoD"
                     /locus_tag="ACL8AS_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0016987 - sigma factor activity [Evidence
                     IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HGS1229166.1"
                     /translation="MATKQKEVTTFDVQVAEFIRNHKQKGTATDDEINASLVIPFTLD
                     ADGIEDLLQRIQDAGISITDNEGNPSARVLSNEEEPELSDEDLIGSTSAKVNDPVRMY
                     LKEIGVVPLLTNEEEKELTLAVEAGDIEAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRIVLREQLDEILDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRQPSRSKPLRDFIED"
     gene            complement(11351..13111)
                     /gene="dnaG"
                     /locus_tag="ACL8AS_001315"
     CDS             complement(11351..13111)
                     /gene="dnaG"
                     /locus_tag="ACL8AS_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003896 - DNA primase activity [Evidence
                     IEA];
                     GO_process: GO:0006269 - DNA replication, synthesis of
                     primer [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HGS1229167.1"
                     /translation="MVDKQVIEEIKNNANIVEVIGDVISLQKAGRNYLGLCPFHGEKT
                     PSFNVVEDKQFYHCFGCGRSGDVFKFIEEYQGVTFMEAVQILGQRVGIEVEKPLYSEQ
                     KPASPHQALYDMHEDAAKFYHAILMTTTMGEEARNYLYQRGLTDEVLKHFWIGLAPPE
                     RNYLYQRLSDQYREEDLLDSGLFYLSDANQFVDTFHNRIMFPLTNDQGKVIAFSGRIW
                     QKTDSQTSKYKNSRSTAIFNKSYELYHMDRAKRSSGKASEIYLMEGFMDVIAAYRAGI
                     ENAVASMGTALSREHVEHLKRLTKKLVLVYDGDKAGQAAILKALDEIGDMPVQIVSMP
                     DNLDPDEYLQKNGPEDLAYLLTKTRISPIEFYIHQYKPENSENLQAQIEFIEKIAPLI
                     VQEKSIAAQNSYIHILADSLASFDYTQIEQIVNESRQVQRQNRMEGISRPTPITMPIT
                     KQLSAIMRAEAHLLYRMMESPLVLNDYRLREDFAFATPEFQVLYDLLGQYGNLPPEVL
                     AEQTEEVERAWYQVLAQDLPAEISPQELSEVEMTRNKALLNQDNMRIKKKVQEASHVG
                     DTDTALEELERLISQKRRME"
     gene            complement(13201..13959)
                     /locus_tag="ACL8AS_001316"
     CDS             complement(13201..13959)
                     /locus_tag="ACL8AS_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229168.1"
                     /translation="MTAIVELKNATKIVKNGFDEEKIILNDVSLEIFERDFITILGGN
                     GAGKSTLFNTIAGTLSLTSGTIRILGEDLTKFSPEKRAKYLSRVFQDPKMGTAPRMTV
                     AENLLIAKFRGEKRGLLPRRLTSYKDEFQATIEKVGNGLEKHLNTPIEFLSGGQRQAL
                     SLLMATLKRPELLLLDEHTAALDPKTSVALMELTDEFVKKDQLTALMITHHMEDALKY
                     GNRLIVMKEGRIIQDLNQEEKAKMKISDYYQLFE"
     gene            complement(13956..14822)
                     /locus_tag="ACL8AS_001317"
     CDS             complement(13956..14822)
                     /locus_tag="ACL8AS_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229169.1"
                     /translation="MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVA
                     VTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGKIPTLLSGILVMTSCHSIMLLIM
                     GRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDN
                     PDMARSFGIHTGRMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLII
                     GEVIFKSLSLAERLVTIVVGSIAYQFLVWAVIALGFNTSYLRLYSALILAVCLMIPTF
                     KQTILKGAKLSK"
     gene            complement(14891..15895)
                     /gene="trpX"
                     /locus_tag="ACL8AS_001318"
     CDS             complement(14891..15895)
                     /gene="trpX"
                     /locus_tag="ACL8AS_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1229170.1"
                     /translation="MKNKRLIGIIAALAVLVAGSLIYSSMNKSEVQNNKDEKKITKIG
                     VLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGND
                     LVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHNPAQQQ
                     VELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTV
                     TVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHD
                     LGVATGKMIVQVLKGAKPADTPVNVFSTGKSVINKKIAQELGITIPESVLKEAGQVIE
                     "
     misc_binding    complement(16008..16225)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(16308..19004)
                     /gene="ppc"
                     /locus_tag="ACL8AS_001319"
     CDS             complement(16308..19004)
                     /gene="ppc"
                     /locus_tag="ACL8AS_001319"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008964 - phosphoenolpyruvate carboxylase
                     activity [Evidence IEA];
                     GO_process: GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA];
                     GO_process: GO:0015977 - carbon fixation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HGS1229171.1"
                     /translation="MSLQKLENYSNKSVVKEEVLILTELLEDITKNMLAPETFEKIIQ
                     LKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNID
                     QDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRK
                     YRDVKLGLINKDKWHNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVP
                     HLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNY
                     YDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQAT
                     KTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYL
                     ASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAE
                     KSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTER
                     ARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYL
                     SSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIR
                     LTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITQKKSDTNTPNRYEAIMDQVVDRS
                     YDIYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWS
                     QSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNI
                     AFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYF
                     NILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG"
     gene            complement(19024..20253)
                     /locus_tag="ACL8AS_001320"
     CDS             complement(19024..20253)
                     /locus_tag="ACL8AS_001320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HGS1229172.1"
                     /translation="MKISKRHLLNYSILIPYLLLSILGLIVVYSTTSAILIEEGKSAL
                     QLVRNQGIFWIVSLILIALIYKLRLDFLRNERLIILVILIEMLLLFLARFIGISVNGA
                     YGWISVAGVTIQPAEYLKIIIIWYLAHRFSKQQEEIATYDFQVLTQNQWLPRAFNDWR
                     FVLLVLIGSLGIFPDLGNATILVLVSLIMYTVSGIAYRWFSTILALVSATSVFVLTTI
                     SLIGVETFSKIPVFGYVAKRFSAFFNPFADRADAGHQLANSYFAMVNGGWFGLGLGNS
                     IEKRGYLPEAHTDFVFSIVIEEFGFVGASLILALLFFMILRIILVGIRAENPFNAMVA
                     LGVGGMMLVQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAVAFVLNIDASEKR
                     AKLYRELENQPMNLLLK"
     gene            complement(20409..20711)
                     /locus_tag="ACL8AS_001321"
                     /pseudo
     CDS             complement(20409..20711)
                     /locus_tag="ACL8AS_001321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0032196 - transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(21159..21380)
                     /locus_tag="ACL8AS_001322"
     CDS             complement(21159..21380)
                     /locus_tag="ACL8AS_001322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HGS1229173.1"
                     /translation="MYRRLRDLREDHDLTQKQIAKILSFTDSAYAKIERGEHTLTADI
                     LVTLSNFYDVSTDYLLGLTDFPDKIRFRK"
     gene            complement(22060..23271)
                     /locus_tag="ACL8AS_001323"
                     /pseudo
     CDS             complement(22060..23271)
                     /locus_tag="ACL8AS_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428251.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
     gene            complement(23273..24517)
                     /locus_tag="ACL8AS_001324"
     CDS             complement(23273..24517)
                     /locus_tag="ACL8AS_001324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit family protein"
                     /protein_id="HGS1229174.1"
                     /translation="MHIVLFRYSARVVKLKYLYNRNVVIIAPEVQRKKYEDYLAEGNN
                     LPKVIFLEDFILPNIILEIRRISQNTEVESITTLSEEDMDIVGFLNDHFVEKNTHSVS
                     NLLFKDKYFMRSFLVGVVNQPYFRLLESENDLRVFWNNCKSSAAILKPRNEAGSNGIK
                     KVYPNEKIDSVYFEKNYIIEEYIDIDNMITCDGYSIGSEIKRFYVHEYEELLFNTLSS
                     SGYYLVRTSSLYNDSEKIEYIEKALEECRKVLNVFSINSEITPFHFEWFLELSTGKIV
                     FCEVGKRFGGGDIPQLIEDSHGVDVIKEYWDILTNSQGLKKINFSKVISRPANISATF
                     ALYRKQGKVIEVPDEKELAWAKKVYIFIKPNTYYKVSENVVENSMLVQFNCKNSCEFE
                     KRLDELKHISQKFKYVITDSGE"
     gene            complement(24541..25569)
                     /gene="galE"
                     /locus_tag="ACL8AS_001325"
     CDS             complement(24541..25569)
                     /gene="galE"
                     /locus_tag="ACL8AS_001325"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000838666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HGS1229175.1"
                     /translation="MKSLLITGGAGYIGSHTVLDLLDNNYEVTIIDDLSNSKKKVIES
                     IKQISKKSRNLHFYKIDLKNEEKLENVFKRHNFDGVIHFAGYKAVGESVVEPLKYYEN
                     NLLSTINILKLMKKYKVFNFVFSSSATVYESTPIMPFYETNPLKASNPYGRTKQYIEV
                     LLNDLFISNSNWKIVCLRYFNPLGAHESGDLGEDPNGIPNNLVPYITQVAIGKLPYLN
                     IFGVDYSTPDGTCIRDYVHVNDLAYGHRKALEYIFNTDEGLYEVINLGSGVGFSVFEI
                     LHSLESVIGSYIPYKITSRRAGDMDVSIADISKAEELLGWKPRYDIMKMCQDTWKWQQ
                     KHPNGYDD"
     gene            complement(25571..26242)
                     /locus_tag="ACL8AS_001326"
     CDS             complement(25571..26242)
                     /locus_tag="ACL8AS_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229176.1"
                     /translation="MIRLPNKFKGNNITLEVKLNKAVDASVLYPDVKSLDQELYRQLQ
                     SVESFYLTFSDMYSEINENNEILYTEIIFKIPLCIGEDYFNFPVVSYVSNPYSLIRGF
                     YLGFHKELDCNYVFDDAELHFFREGICEFNFEFKNQNSIITAELPREYNYPLILFNNS
                     NLVNQYGKYTLLDIDKYKLESRKIFEFPEISIGNFLGSEAKSNRVIFSQDKFQINGIK
                     NMEVN"
     gene            complement(26245..>26749)
                     /locus_tag="ACL8AS_001327"
     CDS             complement(26245..>26749)
                     /locus_tag="ACL8AS_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000490588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229177.1"
                     /translation="NTSNFNIESLFLEFIDSQENIRVVSLLDCLIQLSSKNIEISGNY
                     KGHTVKKILKKFALYSVITKLDITKVNHLLRNDYIYFLMKEIDNITKKYPKLIQKYPR
                     DILSDRYGITNEVYRYLIGENLHIKINHKLDEVRYFTDIPFIDTSLSIEEFDKIVSKI
                     LKIKVGG"
BASE COUNT         8250 a         5726 c         4327 g         8446 t
ORIGIN      
        1 taaaaaaggt aaatttaaga ttggcaatac gaacgttaaa cagaattcca tttctctttt
       61 tagaatcaaa acgacaatat tgtggaatct ctacaggaac aatagactgc gacactaaaa
      121 tatcctctct tagttttact ttactaatag tatataggag gagagccctg aatcctagac
      181 cctttgttat gatgcgctta caaacagagt tggaaaaaat cttaaaagca gaaaaacgca
      241 tgatatcagc ccctaacact tgatacaatg cgttttatta tgaaaagatc tactggattt
      301 tttatcaaaa taaacttcca gtagtctttt cactttttat taataagttc cttcttcacc
      361 ttggctagtc aagataacag gtccatcttt cgtaatgaca aattggtgtt catactgaca
      421 tgacaatcca ccgtcaatgg tcttatgcgc ccaaccagtt ttcatatctg tatcaatttc
      481 ccaatcgcct gtattgatca ttggttcaat ggttaagacc attccttcac gaagacggag
      541 tccacgacct gcaataccat agttaggaac cattggttct tcgtgcatag ttgggccaac
      601 accatgacca accaaatcac gcactacacc gtaaccacga ctttcagcgt attcttgaat
      661 agccgcaccg atatcaccga tacgatttcc aacaacagct tgctcaatac ccttgtacat
      721 agcttctttg gttacatcca tcaagttttt gacttcttcg gacggtgtac caacagcata
      781 agcccaacat gagtctgcta aaccaccaga atagctctga gtgtattttt tcatttgttc
      841 aacattgttg aagtttaatt ttgagacatt taggtcagat ttagcaatgg gacctcccaa
      901 aaccatatca actttgagca aatcaccatc tttcaagata taatgacgag ggaaagcgtg
      961 agccacttca tcgttaagag agcaacaggt agcataagga tagtccatca tggcaccgtc
     1021 aaccccaatc tgaagtggaa ggaaattttc ttctttacaa cgacggcgga catattcttc
     1081 aacttcccac atatctacgc ctggcttaat caaatcacgt aagcctatat gaatacttgc
     1141 tagaaaatca ccagccttgt ccatagcttc gatttcacga gctgatttta atgttatcat
     1201 cttttctcct agtttctaat taattttaac agtcacattt gcttttgaaa caatctggtg
     1261 accatgataa atatcgtaat caattatagc tgaccgtctc gtatgatgaa taatccgtgc
     1321 ctgaatgcgc aatatatcat ctatctgaac agcctgcaaa aagtagatca gcatctgctc
     1381 gataatgaga ttgcgaccac tattaacaac taaatcttgg gtcatgtggg tcagaatttc
     1441 tgccaataca ccattagcca aaactccatt tttttctagc ataaagggtt ccactgtaat
     1501 gactacttca tcatggtgat aagagagctt ttgtccaatc tgctcagaaa aagttggtag
     1561 agccgaaact tgggaacggc tcatcttctc catgacatct cgtcgcgtca caacgccaag
     1621 caaagtttga ttgcttcgaa caactggtac catttcaaag tcttctgcga tcatccgttg
     1681 actcacattg gcaatatttg tcgataatcc aaccaaaaat agactacgag acataacctt
     1741 atcaattgtc gtgcttggtg atttatcacc agcgtctctc atggttacaa caccaacaac
     1801 gacctgatgt tgattgataa cagggaaacg gctgctacga ttcttacgaa ccaagtccaa
     1861 ataatcttta actgtatctg tctctctcag aaaaccatac tcatgactag ggcgataaag
     1921 tttctcaact gtcagaatat cagtcttgat ttggacattt gacaaggctt tattgatcat
     1981 ggtcgcgacg gtaaaggtat catgcttact tcttagaaca ggaatccctt tttgattggc
     2041 cagtttaagc acatcatcat gaacctgaaa tccccctgta accagaactg cattttcatt
     2101 ttccaaggct agcaactgaa tacgggttcg gtctccgaca atcaagagcc ccccatcatg
     2161 aaggtaagac aagatatttt gttcagtcat ggcaccaatt gaaaacttac taaactctct
     2221 ctctaaacct tcttgcccag ccagaacctc agaagaagtc acttctgcaa tttcagcaaa
     2281 cgttaatctc tctatagcaa ctttctggga tttaacacga attgttccac ttctaggacg
     2341 ggtctccaca attccacggt tttcagcttc tttaatagcc cgataggctg ttccatcact
     2401 aactcctaga tgattcgaaa tgctacgaac actgaccctt ttacctactg gtaattcctc
     2461 caaatagctt agaatttcct gatgcttact cattgaactc tccttttaca taccgaaatt
     2521 caagataatc ccgcattttt cttgtgtaac gatcacttcc cttaaactga cggaacaaac
     2581 taaatccaga cttaagagca actctttggc tagctttatt ttcaaggtgg gtaatgataa
     2641 ataattgttt taagccaaat tcctcaaaag aaagctgaca aatttttcta acaacctctg
     2701 tcataaatcc ttgcgaccaa gcatcttttc tcaaaaaata gccaagctca gcttcttttt
     2761 tgatttcatc taacttctca aatttaatag aaccaatcat ttgttgattt ttctggtcac
     2821 aaattgccca cactcccaaa ggggacttca taaagtaatt ggccagtgca tattgacttt
     2881 cttccagact tgcctgcgtt gggaaaataa attgaagatt ttctggattt gaagctatct
     2941 cgcggaagtc ctgactatca ctaaaaaaga aaggacgcaa atacaagcga tccgtttcaa
     3001 aaaaagaaaa cattgctaat ttggtccaaa tattcataaa cacctctacg gtttaatcct
     3061 caacaagtct aatatccgct cctaaattac gtaatttttc gataatatca gaataaccac
     3121 gtaagataaa ctcgatattg gtaatttcag ttttaccttc agccataagc ccagcaatga
     3181 ctagtgcagc cccagctctt aagtcggtcg ctttaacact ggccccacgt aaatcacgtc
     3241 cacccgtgta caaaatatga ccatttgttg tcgaaatatc cgcatccatc tttgctagtt
     3301 caaaaacatg atttacacgt ttttcgtaaa tcgtatcgac aattgtacca cgaccattcg
     3361 ctcttagtaa aagaggggta agcggttgtt gcaaatcagt tgcaaagcct gggtaaggag
     3421 ctgtcttaat attgattgct ttcaaattag actgttcctc gacaaaaatg ctgtcttcag
     3481 atacagtcat tctcactccc atttcttcca acttagcaat aaacccttcc aggtgttcgt
     3541 aaagaacatt atttatacga attcctttac caactgcagc agctaaagat atatatgttc
     3601 cagcttcaat gcggtctgga atcacctgat gacgtgtccc atgtaatctt tcaacaccat
     3661 caataatgat gatattagtt cctgccccac ggatatgggc acccatatta ttcaagagag
     3721 tagctacatc aataatctca ggttcacggg ctgcattttc aataatagta cgaccatttg
     3781 ctttaaccgc agcaatcatc gtattaatcg ttgctcccac actaaccgta tccatgtaaa
     3841 tacttgcacc atgaagtcct gtatctttag cagataactt catgttatct ccctcgtagc
     3901 tagcagtggc acccatagct tcaaacgcct taaggtgtaa gtcaatcgga cgaggaccaa
     3961 gatcacatcc tcccggtaga ccaactgtcg cttcaccaaa acggcctaag aggctcccat
     4021 aaaaatagta agatgcacga agactgttaa ttttaccata aggcattgga atattttgaa
     4081 cacctcttgg gtcaatctcc aatacatcgt cataacgctt aacagtagct cccatcaatt
     4141 ccatgatttc gacaagactg gctacatccg aaatatctgg aacgcaatcc aaagtcacca
     4201 catcatcagc caagataata gctggaatta aggcaacgac actattttta gcaccactaa
     4261 tagtgatttc accttgcagt ggtaatccac cattgataac aatttttctc attctaagtt
     4321 ttcaatactc tttcaagatt tctaataagg tcttcaaaat aaagtatatc ataaatttat
     4381 ccttttttcc atccttttca attttattgg ataaatcaga gttgacgagt tagtaactga
     4441 attactaata ctcaatgaaa atcaaagatc aaactaggaa actagccgca ggttgctcaa
     4501 aacactgttt tgaggttgta gatggaactg acgtagtcag tatcctacac atacgacaag
     4561 gcgatattga cgtgatttga agagattttc gaagagtata atctttctcg aatcgctatt
     4621 gccccttttt tatcccctaa aactgagtag gagctaagac tagatctctt atctaagtat
     4681 cggaatacgg ctgttcaact aaattttagc aagaacttct cccccttctc tcagttcaca
     4741 gaagcgtttt atacataccg tcctatcaga cagataaccg tgactcagga tcacttctat
     4801 ctgtcgtttt ctctttatag tgatagacct cacgggataa gtcgtacatc tttcctcgtg
     4861 tatacaagat ataaggacgt taaaaggtta cagtgaaaat agaaaatctt agtacgaatt
     4921 caattactct cgtgatttac gcatataggt tacgactacc tttttggact ttagagtttg
     4981 agaccccctt atccgctata tacgccttat tatcacgttc ctgttcgtag agccacgatt
     5041 tcgctatccc ttcttctgac aattcttatt tccagcgtca gacttaaaac ggtctatccc
     5101 cagaccattt taatctgcta cctcacgata gtcaggcttg ggaatcgcta tttgactcgc
     5161 cgagaacttt gacatcagat atactataac aaattgaaat aagaatcaaa caatttaatt
     5221 ttgaaattca aatcaattta taacaatata gttgattgaa actagaatag tacatctctg
     5281 cttctaaaac attgttagaa atcgatttta ctgtcctgat cgatttgtcc tgttctcatt
     5341 tcattttact atattttaga agatatgctg tgctattcca gattcagttt gctatacatg
     5401 cctgtcgtac cacaaaatcc cgtgtctgat gaggcacggg attttttagc ttctttactg
     5461 agatggattt tcctttttag ttcgtgccaa tctcaaggca cgatttggat tgagacgatt
     5521 aaatagttct tccaatttct tttcattcca aacgtctgcg gcggaaacaa aattaccatc
     5581 cgcatctcgg aaagatatcg gtttatctcc cataccagtc tcctagtcta caaattcaaa
     5641 ctcaaattta ccaatgcgga ccaaatcccc atctttagct ccacgcgcac gaagggcttc
     5701 atcaaccccc ataccacgaa gctgacgggc aaatttcatg acagattcat cacgatcaaa
     5761 gttggtcata ttaaagagtt tcatgagttt ttcaccagaa agtacccatg tcgcatcgtc
     5821 atcacgacta atttcaaagg ctttttcttc ttcgtcaaat ccatagtaag cttcttcttc
     5881 catatcggac tcgtcgtaga gcaaaaattc tggtgtcttg tctaacaatt cagctgtagc
     5941 atctaaaagt gttgccagac cttgcttggt caatccagaa attgggaaga tagctggtaa
     6001 ctcttcaaat tcatcataat tttcagccaa ttttttctta aagtcttcaa gattttcctg
     6061 actctcaggc atgtccatct tattagctac aataatctgt ggacgctcca tgaggcgaag
     6121 attgtaagac tccagctctt tattgatagc taggtagtcc tcatatggat cacggccctc
     6181 gctagctgac atatcaatga tgtgaaggat aacacgtgta cgctcgatgt gacggaggaa
     6241 ctgagttccc aaaccaacac cttgactagc cccttcaatc aaacctggca agtcggctac
     6301 tgcaaaggat tcacctgatt gggtgcgaac catacctaaa tttggtacaa tagtggtaaa
     6361 gtggtaggca ccaattttag gcttagctga ggtaataaca cttaaaagtg ttgacttccc
     6421 tacagatggg aatcctacta aaccgacatc tgccaagatt tttagttcca attgtaactc
     6481 acgttcctga cctggttctc cattttcaga gatttccggt gcaggatttt ttggtgtcgc
     6541 gaaacgaata tttccacgtc caccacgacc accgtgggca acgataaatt cttgcccatg
     6601 ttcaatcaaa tctgttaaaa ccttgccagt ctccgcatca cgaacagtcg taccttgtgg
     6661 tactcgaact ctaaggtcct cagcaccacg accatgcatc cctttggtca tccctttttc
     6721 accagaatca gccttgaaat gacgattgta gcggaaatcc atcaaggtac gtagtccttc
     6781 gtctacaacg aagaccacat tgcctccacg accaccatca ccaccccaag ggcctccatt
     6841 agggacatat ttttcacgac gaaaggcaac cataccatcg ccaccattac cagccttgac
     6901 cttaatctta gctgtatcta aaaacatact cattatttct tctcacttta aaaaagggct
     6961 gggaaatccc agtcactaaa ttttcttgaa tctattttat agattactga gggcaccaat
     7021 tgcagttgca aaaattccca ataaacttgc tactagcatg ataatcacga taaacaaggt
     7081 tattttctca aacatagttt ttttacgatt tccattatct ccaaatgcca tttttctctc
     7141 cttcgttaca ttctattttc tattatctta gcatgaattg agctagtttt caatagtcag
     7201 ttgctactgg tgcgataatc cataaaataa tgtaagctac aattccagct ccgtaacagc
     7261 aagtaagaac accccaaatg acttgaacga tagtcggatc catatccaga taatgggcca
     7321 ccccagcaca aacacccgca atctttttat cacgaccgct tctcattaat tgtttttttc
     7381 atagctgttc ctctttctat tcttcatggt ctttccaata gtctctcata ctgatcaact
     7441 gtgtttttga agccttcaac atgcgtctag atccttttac aggtacagca accacctgtt
     7501 gctgaagata caaaactgtc ttaaagatac gctgactgac cgtatcatct ttagccaaat
     7561 ctttctggaa gttatttgaa ataatggcat ccagataaaa ctcatgcact cgtttcccaa
     7621 agttctcagc tgaaatctca tacaatttct ctgataaggt atgctcgttc atgtctggtg
     7681 ttgcaatcag ggcttccaaa atagcaccag ccaaatcatg ttctccatag tacaaggttc
     7741 caaacatttt atcactgatg aggttgttca aataaggatt tccgtgagca atgacaggtg
     7801 ttccactggc taagctttcc aagtaggtca aaccttgcgt ttcgcttgtc gatgccgaaa
     7861 tgaagaaatc cgccgcttta tagtaaagag ccgtctcact aggagcaatc atccctgtaa
     7921 agatgactga gtcttgaatc tctaggttct gggcttgctc tttgaggtca ttcagataag
     7981 ggccatcccc agctactacc agtttaacct tgtcttcctc tttcagaaca tcagcaaagg
     8041 ctgctaaaac tgcttgaata tttttttcat aggagattct cgaaagacta agcaacgtct
     8101 tttcaccatc ttgaatccct agtttactac gcagttcttt caaattttcc tgcttgattt
     8161 ccggacgctc aaacttggct aattcaatcc cagtaggaat gacccgtttt tcaaccttga
     8221 ccttataatc agatagcaag tcacggacaa tctcactagg gcaaataacc ccatccacat
     8281 catgcaggaa acctctaacc agatacttga ccatactcga ccggatcaac atccccttag
     8341 caatataatg gacatagtct tcatactggg tgtgataggt atggatgact ggaattttca
     8401 attcacgcgc aatccaaatc cccaacaggc caagagaaaa ttctgtctga gtatggataa
     8461 tatctagctg atactgttta gcaatttcaa gtgccttgct aaaacctcgg taggcaaagc
     8521 gacgatcctt aaaagcaaag aaaggaacac ttggaatgcg gataatttgc caatcttcgt
     8581 agcgattgac atccttatct gtcgtcgtaa agataaaaac agcatgtccc tgcttttcaa
     8641 gttctgtttt caaggttcga atactggtcg caacaccaga aacctgagga aaataggtat
     8701 ctgtaaataa accaattcgc atagattacc tcacttttta ctttctccct aaagcggctt
     8761 gtttctcata aaagtccaac cagatttgta acagatgctc ttcagaatac tctctggaaa
     8821 tattcttggc cttttctttg agatctttta agacagcagg atttgcttga tattccaaaa
     8881 tagcctcttt catctcttct ctacccgctg tcgcccgata atttccctcc aaaatcacct
     8941 tatagagatc taaatcacgc aacataatag gagcctcaca actcgcagct tctaaaatag
     9001 tcataggaaa gagctcattg taactaggca acaagaaaag atccgctaga gcatacaatt
     9061 cgcgcatccg ctctggcgat acaatgcctg gaaaaatcaa atttttaggg ggattttcca
     9121 taattttctt atagtgttca taaccatctg tcataccacc aaaagagaag ccaccagccc
     9181 agataaaggt aatctgaggc aattcctcag ccagacggat aaagtcatca atccctttac
     9241 gtttctgaac ttgcccagca cctactacga taaactgatt gtcactaaga ccaagatctg
     9301 tgcgcagtct gactacctct tcttgtggta gaggatgcca tttttccttg ttgacaaagt
     9361 taggaatata ggtcactttt tcacgtggaa taccagctgc taccaaatcc tcaataaaca
     9421 taggattgac cacaaccaag tgctccatcc ggttgtaaaa agaaaataca tagcgtttca
     9481 caattccctt taagaaaaat ggaattttca aacttccttc aagtgtagct ggcaagaaat
     9541 gcacatagcc aatctttctc cctgagcgtt tcttttggaa ggttgataaa taatagggaa
     9601 aatcaatcgt atgaaagtga gtcacatctg cctcgattgg aagattttct gtaacaatca
     9661 attggtcctt ggcagcacgg tgaagaagac gaactaattc acggtaagca cctgaaactc
     9721 cctgtcctgc tactttctca cttgaactca acatattgat gcgtaatttc tttttctcca
     9781 taactactat tatatcattt tctttgaata aaatcagcaa aagaaaggag agactagagg
     9841 aaaagagggg aaatttcctc gcttttccaa cagtctctca catgctttta tatgtttact
     9901 taatgcctag ggcaatgcgg gcatagcgac tcattttttc aactgtccag gctggatacc
     9961 agactaattt aacctcagta tccgttactt ctggaacctc tatcatagca tcataaatct
    10021 ggtctgtcaa aaggtctgct aagggacaac ccatagttgt caaagtcatg tcaatctctg
    10081 tttgccctgt gtcaccgtca aaacgaatct catagatcaa accaagattg acaatatcga
    10141 ttcccaactc agggtcgatg acttcttcca aggctgttaa aatccgtgtt ttgatgtttt
    10201 caatttgctc ttctgtataa gccatatttt cctcactctt agtcttcaat aaaatcacga
    10261 agcggtttgc tgcggcttgg ttggcgtagt tttctcaaag cctttgcttc aatctgacgg
    10321 atacgctcac gagttacgtt aaagactttc cccacatctt caagtgtgcg catttttcca
    10381 tcatctagtc caaaacgtag acgcagaaca ttttcttcac ggtctgtaag agtatctaag
    10441 atttcatcca attgctcacg caagacgata cgagtcgtat aatccactgg attttcaatt
    10501 acttcatctt cgataaagtc tccaaggtgg ctatcgtcct cttcaccgat aggagtttca
    10561 agagatactg gttcttgggc aatcttcaag atttcacgaa ccttatcagg tgtcatatcc
    10621 attcgttcag caatctgttc tggtgtcgga tcttgcccca attcttgaag gagattccgc
    10681 tgttcacgaa ccaatttatt gatagtttca accatgtgaa ctgggatacg gatggtacga
    10741 gcttgatccg caatagcacg agtgatagcc tgacgaatcc accaagttgc ataagttgaa
    10801 aacttgaacc ctttagaata gtcaaacttg tcaaccgcct tcatcaagcc catatttcct
    10861 tcttgaatca agtcaaggaa ctgcatgcca cgaccgacat agcgtttggc aatagaaaca
    10921 accaaacgaa gattggcttc cgcaagacgt tgtttggctt cgatatcgcc agcttcaaca
    10981 gccagtgtca actctttctc ctcttcattg gtcaagagag gaacgacccc tatttctttc
    11041 aagtacatac ggacagggtc attgacctta gcagaagttg acccaatcaa gtcctcatcg
    11101 ctgagttctg gttcttcttc attgctaaga acacgcgcac ttggatttcc ttcgttatct
    11161 gtgatagaaa tgcctgcatc ctgaatccgt tgcaagagat cttcaatccc atcagcgtcc
    11221 aaggtaaaag gaataaccag acttgcattg atttcatcat ctgttgctgt ccctttttgc
    11281 ttatgattac ggataaattc tgctacctgt acgtcaaatg ttgttacttc tttttgtttt
    11341 gttgccatta ttactccatt cttctctttt gggaaattaa acgttccaat tcttctaggg
    11401 ctgtatctgt atctcctaca tggctagctt cctgcacctt ctttttgatt ctcatattgt
    11461 cctgattcaa gagagccttg tttcgagtca tctctacttc actaagttcc tgcggcgata
    11521 tctcagcagg caaatcctga gctaaaactt ggtaccaagc tctttcaact tcctctgtct
    11581 gctctgctaa aacttctgga ggaagatttc catactggcc aagcaagtca tataagacct
    11641 gaaattcagg tgtagcaaat gcaaagtctt ctcgcaaacg gtaatcgttc aaaacaagag
    11701 gggattccat catccgatag agtagatggg cttctgccct cataatagcc gataactgct
    11761 tggtgatagg catggtgatt ggcgtcggtc tggaaattcc ttccatgcga ttctgccttt
    11821 gcacctgacg actctcatta acaatctgct caatctgggt ataatcaaag gacgccagac
    11881 tgtcagctaa aatatgaata tagctgtttt gagcagcgat ggacttttct tgaacaatca
    11941 agggagctat tttttcaata aactcaatct gagcctgcag attttcactg ttttcaggtt
    12001 tgtactgatg aatgtagaac tcaatcggac taatacgagt ttttgttaat agataggcca
    12061 agtcttctgg accatttttt tgtagatact catcaggatc caagttatca ggcatgctaa
    12121 ctatttgcac aggcatatca ccaatttcat ccaatgcttt caatatcgcg gcttgcccag
    12181 ccttatctcc atcgtaaaca agaaccaatt tcttggttaa ccttttcaga tgctcaacat
    12241 gctctcgact caaggccgtt cccatcgacg ccacagcatt ttcgattcca gcccgatagg
    12301 ctgcaataac atccatgaat ccttccatca ggtaaatctc actagctttt ccagaagatc
    12361 tttttgccct atccatatga tataattcgt aacttttgtt aaaaattgca gtcgatcggc
    12421 tgtttttata cttagaagtt tgtgaatccg ttttttgcca gatacgacct gagaaggcaa
    12481 tgacctttcc ttggtcattt gtcaggggaa acataatgcg attgtgaaag gtgtctacaa
    12541 attgattggc atccgagaga taaaacaggc ctgaatccag taaatcctct tcacgatact
    12601 gatcagacaa acgttgatag agatagtttc gttctggagg tgctaaacca atccaaaaat
    12661 gtttaagcac ttcatctgtc aaaccccgct gataaaggta atttctggcc tcttctccca
    12721 tagtcgttgt catgagaata gcatggtaaa atttggctgc atcttcgtgc atatcataaa
    12781 gagcttggtg aggcgaggct ggcttctgtt cactataaag cggtttttca acctcaatcc
    12841 cgacacgctg acctaagatt tggacagcct ccataaaggt aaccccttgg tactcctcga
    12901 tgaatttaaa gacatcacct gagcgaccac aaccaaaaca gtggtaaaac tgcttgtcct
    12961 ctacaacgtt gaaagaaggt gttttttcac catgaaaagg acagagccct agatagttcc
    13021 gtcctgcctt ttgtaaagaa atcacatctc ctatgacttc cacaatgttg gcattgtttt
    13081 tgatttcttc aatgacttgt ttgtcaacca tacacaatac ctccatgtta tcatagttta
    13141 ctttatatag tatactttat ttcagaaaaa aagtaaacca tttcactcat tttccctact
    13201 ttattcaaag agttgataat aatcagagat tttcattttt gctttttctt cttggtttaa
    13261 atcttggata atccgtcctt ctttcatgac aatcaagcga ttgccgtatt tgagagcatc
    13321 ttccatatga tgagtaatca taagggctgt tagctgatct ttcttaacaa attcatctgt
    13381 caattccatc aaagcaacac tagtctttgg atccagggca gcagtatgct catctaacag
    13441 gagtaattca ggtcgcttca aggttgccat caagagactc aaagcctgtc tttgtccacc
    13501 tgataagaac tcaatcggtg tattcaagtg tttctcaaga ccatttccta ctttttcaat
    13561 ggttgcctga aattcatcct tatagctagt caagcgtctt ggtaacaatc cacgcttttc
    13621 accacgaaac ttggcgatta aaagattttc agcgaccgtc atacggggag ctgtccccat
    13681 ctttggatct tggaagacac gagacaggta cttggcacgc ttctcgggtg aaaacttagt
    13741 gagatcttca cctaaaatac ggatagttcc actagttagt gataaggtcc ctgctatagt
    13801 gttaaagaga gttgattttc cagcaccatt tccgcccaaa atcgtgataa agtcccgttc
    13861 aaaaatttct aaggaaacat catttaaaat aatcttttct tcatcaaagc catttttaac
    13921 gattttggtt gcatttttta attctacaat tgctgtcatt tgcttaactt ggctcctttc
    13981 aagattgttt gcttaaatgt tggaatcatg aggcagactg ctaaaatcaa agcactgtat
    14041 aaacgaaggt aacttgtatt aaagccaagt gcgataactg cccacactaa aaattgataa
    14101 gcgatagaac ctacaacgat agtaaccaaa cgctctgcca agctcaaact cttgaaaata
    14161 acttctccaa taatcaaact tgcaagcccc acaacgataa ccccgatccc tcgagacaca
    14221 tcggcatagc cttcttgctg agcaatgagg gcacctgcaa gggcaatcac accatttgat
    14281 aagaccaagc ccatgagctc catgcgtcca gtatgaatcc cgaaacttct agccatatca
    14341 ggattatccc ctgtagcaat ataggcttgt ccgagtttag tgtccaagaa aaagagcatg
    14401 agagcaataa caatgctcac aaagatgaga cctgtcaaga gttgattcaa atccgaatca
    14461 aaaggcaaaa catcctgaat ttgcttggtt ccaagcaggc ctaaatttgc acgtcccata
    14521 atcaagagca tgattgagtg acaagaagtc atcaccaaaa tccctgagag caaggttggg
    14581 atcttccctt ttgtataaag aaggcctgct gccattccag ccaaacaacc tgctcctaca
    14641 gcaacaagtg tcgctaaaaa tggattcacg cctttggtta tcaaagtgac agcaacagct
    14701 cccccaagag ggaaggaacc ttctgtcgtc atatctggaa agtttaaaat cctaaatgtc
    14761 ataaagattc ccagacctag aatagcccag acaaatcctt gagaaataat ggaaacaatc
    14821 atattttatt taatcctttc tatattcatc tttttaaaaa atgggaagag tctcctcctc
    14881 cctaccttat ttattcgatg acttgtcctg cttctttgag aacagactca ggaatagtaa
    14941 tacctagttc ttgtgctatt tttttattga tgactgactt accagttgaa aagacattga
    15001 ctggggtatc ggctggtttt gcacctttca agacttgcac aatcatttta cctgttgcca
    15061 caccaaggtc atgttggtca attacaactg atgccaaacc acctacttct accatagctg
    15121 tcgcactggg ataaattggt ttcttagaac tttgattgct agagacaacc gttggaaatc
    15181 ctgatgcaat ggtgttatca attggaaccc aaatagcatc taccttgcta gtcataacag
    15241 tgacagttga ggcaatttca tttgttgaag gaactgcaaa tgtttccact gtcagacctg
    15301 ctttttcagc ataagcctta aattcttcga cctgtgtttt tgaattgtct tcgctacttg
    15361 agtaaagagc tccgattgtt ttcacattcg gtgtcagagc cttgatgagt tcaacttgtt
    15421 gttgagctgg attgtggtca gatacccctg taacgttgcc acctggtttt ttcaaatctt
    15481 taaccaagtt agcaccaatt gggtctgtaa tagcggccat gataaccggt aggtcttttg
    15541 ttgcactagc caacccttgg gctgctggtg ttgcgatacc aaccacaagg tcattcccat
    15601 ttgcaaccaa ttgtttactc attgtcgcaa ccttactttg gtcaccttct gagttcataa
    15661 aatcaatttt aacttgatca tctttatatc cttcttctgc aagtccatct tggatccctt
    15721 tataaatcaa atcaagggat ggatggctca caaattgaag cacaccaatc ttggttattt
    15781 tcttctcatc cttattattc tgaacttctg atttattcat tgaagaataa atcaagcttc
    15841 ctgctactaa gactgctaat gcagcaataa ttccaattaa acgtttattt ttcattctgt
    15901 ttctcctttt tatttccttt aacatatttc acttatctaa acaagcgacg ccattgtttt
    15961 ctttccatac taacctccat caaaaaaatc ctcacacaaa aaacttgtgt gaggacgtcg
    16021 atgcgcggta ccacctcaat tatagggaat ttccctatcg ctcagtctcg caataacgag
    16081 atgcactgta aggtgtgctt accgaatttt tataatttca aattctaaat agcattcagc
    16141 ccaattttca tcattgccac ttatctgttt tcagctacca cagactctct aaaaagtttg
    16201 tatgattact tttctgaatg gttaaattat atcattttta aactacttgt caatagtcta
    16261 ttagaatttt tttgatattc acttttagca ttcactcttg aaaattatca acctgaatta
    16321 cgcaatcctg tcgcaattcc gttgatggtg atatgaatca atcgttcttg atcactggac
    16381 aattctccac gacgttggcg tttaatcaac tccaactgaa tatagttgag aatattaaag
    16441 taaggcatac ggtaatccag actagctttt agatatggat tgtcagctaa gagttcgtca
    16501 tgtccttcaa tagccaagat aacgttctta gtaacttgcc attcatttaa aatagtctca
    16561 tagatggcct taacttgctc gtcttcacaa agtttagcat attcaaaagc aatattcata
    16621 tttgattttg acaaaaccat atcaacattt gaaagaagcg attggaagaa aggccaattt
    16681 tggtacatat ctcgtaagat agcaatattc tctggatttt tattgataaa ttccttgaag
    16741 cttgaaccaa ccccgtacca tccagggaac ataacacgac tctgtgacca tgagaatacc
    16801 caagggatgg cacgcaatcc accgatttca gtaatagtct tacgagcggc tggacgagaa
    16861 ccaatattaa aacttgaaat agccttgatt ggacttgact cgaagaaata atcatagaaa
    16921 tgctcattac caaagaccaa atcacggtag atatcgtaac tacggtccac tacttgatcc
    16981 ataatggctt cataacgatt tggggtattg gtatcgctct tcttctgagt aatcatacgg
    17041 ttaatagctg ccgatactag catttcaagg ttatagtaag cggcgtcttt gttaccgtat
    17101 ttattcccaa ttacttcacc ctgctccgtc aagcggatac gatccttgat agacttgagc
    17161 ggttgagatg taatggcttc ataggttggc ccaccaccac gaccgacagt accaccacga
    17221 ccatggaaga aggtaacctt aacgccaaat tcatctccaa tagcagtcaa ttgttgttga
    17281 gccttgtaga gggtccaaca tgatgacaag taaccgccat ctttattact gtcagagtag
    17341 ccaagcatga tttcttggta gttatttcgt gagtcaatcc attttttggc aaggctaaga
    17401 gaaagatatt ttctcattgt ttcctctgaa tgatccaagt cttcaattgt ttcaaaaagg
    17461 ggaacaatct gaacacgcgc cctttccgta tccaccagtc ctacttcttt taacagaata
    17521 gctaattcta gcatatcaga aagactggtt gcatgtgaaa tgatggtctg acggatgaca
    17581 tcatctccca acttatcttt caaaacacga gccgtcttaa aaatagctaa ttcttttgct
    17641 aataattctg atttttctgc gtgagtcgca gaaagaattc ggggatcttc ttctaattct
    17701 ttcaagagaa ggtcacactt ttcttcttcg ctcaactcgc tataacgaga atgaattcct
    17761 gctgatttca agagttctgc cacacaggct tcatagacgc tagagtcttg tcgcatatca
    17821 attgacgcta agtaaaaacc aaatatctct actgcctgca ataattccac aaaatcacct
    17881 gaaatcaagg actcaccctt attttctagt agagaatctc gaatggcaat caaatccttg
    17941 tagaaatcat tggcggtttc ataacgagtc ccaacttctt catcctcaat cagataggtt
    18001 ttagttgcct gaatttttga ttgaatatca aacaaggcac gacggtaaag ctctttttcg
    18061 cggtaaatag agttatcctt ggattgacga gccatttctc tgacttgctt gctgacgttg
    18121 acaatgctag ttgaaagaga aaattcacga taaagttggt aaatcttttt atcatagtag
    18181 ttcatgatga cttcacactg agtgagtgca gactgcttca aggtctttgc tgtaacaaat
    18241 ggatttccat cacggtcacc acctatccac atacccatgg tgattggttt agcctgtttt
    18301 aaattcagac catgcgcttg cgctaagcgc ttatactccg tcgtcaaatg agggacagct
    18361 ttcaaaaagg agctgttgta atattccata gcattcgtga tttcgttagt cacttttaat
    18421 tttttctcac gaatcatgtc tgtctgcatg ataatttcga tgtaacgacg caaatcattg
    18481 tgccatttat ctttattgat taaccccaac ttaacatcac ggtatttacg caaaagacta
    18541 tgaatatgat ttgttaaatc caacatactt ttgcgttgca cttgtgttgg atgggctgtc
    18601 aaaacaggga caacattcaa gtgttctagg atctcaacgg cattttcctt ttctgctacc
    18661 aatttaatcg ttgtagataa tttacctaaa tagtcctgat caatattatt ttgatgattg
    18721 atttcataag ctaaatccac atcctctgaa atattaatca aaagaggtaa gatagagaaa
    18781 tagcgtgaaa tatagaccat ttcatcattt gataagctag tcactagacg gtttagacct
    18841 tgataatctt cctgcgttga taattctttc aactgtatta ttttttcaaa ggtctctggg
    18901 gcaagcatat ttttagtaat atcttccagt aattctgtta gaatcaagac ttcttctttc
    18961 acaacacttt tattactata attttctaat ttttgaagag acataaacta tcctttcttt
    19021 atcctacttc aacagaaggt tcattggttg attttccaat tctcggtaca acttagcgcg
    19081 tttttcactg gcatcaatat ttaagacaaa ggctactgcc actgataaga ctagaagact
    19141 atttccaccc tgggataaga aggggaaagt cactcctgta gatggaatca agcccgaaat
    19201 ccctccgata ttgacaaata cctgaaccaa catcatccct ccgacaccga gtgcaaccat
    19261 ggcattgaaa ggattctccg ctcggatacc gaccaagata atccgcaaaa tcatgaaaaa
    19321 caagagagct aaaataagac tggcaccaac aaagccaaat tcttcaatca cgatagaaaa
    19381 gacaaagtct gtatgagctt ctggcaaata acctcgtttt tcaatcgagt ttccaagacc
    19441 tagaccaaac caaccgccat tgaccatggc aaaataagaa ttagctaact ggtgacctgc
    19501 atcagcacga tcggcaaaag gattaaaaaa ggcactaaag cgcttggcta catagccaaa
    19561 tactggaatt tttgaaaagg tctcaacacc gattaggctg atagtggtca agacaaagac
    19621 agaagtggca gatacgagcg ccagaatggt tgaaaaccag cgataagcga ttccactaac
    19681 tgtatacata atcaaggaaa ccaagactaa aatagtcgca tttcctaaat cagggaaaat
    19741 tcccaaactt ccaatcagaa ctaggagaac gaatcgccaa tcattaaaag cacggggaag
    19801 ccattgattt tgagtcaaaa cttgaaaatc ataagtagct atttcttctt gctgtttgga
    19861 gaatcggtga gctaaatacc aaataataat gatttttaag tactcagctg gctgaatagt
    19921 tactcctgca accgaaatcc aaccgtatgc cccgtttacg gaaataccaa taaaacgagc
    19981 caagaacaat aaaagcattt ctattaatat aactaaaatg attagtcgct catttctcaa
    20041 aaaatctagt ctcaatttat aaattaaggc aatcagtatc aaactaacaa tccaaaagat
    20101 tccttggttt cgaaccaact gcaaggcact cttgccttct tcaattaaaa tagcactggt
    20161 ggtcgaatag accacaatca agcccaaaat agataaaagc aagtagggaa tcaagatgga
    20221 ataatttaat aagtgcctct tactaatctt catagcatca ccactctact aggatacaga
    20281 taaatctgtt ccaaattccg ttttattttc tagttttgat tgctattata ccattttttc
    20341 agaaagaaaa aaactcttac cttacaatcc ttcgaatttt actgttttta cagaattaag
    20401 gcagaatttg aaatcgtaaa accattttga ataagagttg cttcaaccca ttgactccga
    20461 cggattaagt tgctttcgtg aatgccaaaa tcagccgcaa tttgttcata agtgctctat
    20521 tctcgcatgt attgaatagt taccataagg agatcgtcta ggcttaattt gctttttcgt
    20581 ccaccttttg cgcgtttacg ttgataagct gtttttaaca cagctaacat ctcttcaaaa
    20641 gtcgtgcgct gaacacctac aaggatcttg aaacggctat cgcttaattg tttacttgct
    20701 tcatcatcca tagttttatt gtattgtatt tttgtttcgc aggaagtcta ttattccttt
    20761 cgttccaagg tttttacgct ttttcaagca atcctacaca ctccacgtga tgcgtctgtg
    20821 gaactcaaaa ggttcgggga accttttgag gattaattgc gtttctctaa caaactcaca
    20881 cattcaacgt ggcatgactg atgaagtcat cataagaatt tcacttgctg ctctttctcg
    20941 gtggcagcct gaacggtcag aagtatcatt gtatatcatt tgtatcatgg catataaagt
    21001 atcgctctat tttattgatg gttttaatat cgctcttatc atggcgaacc attcaaatct
    21061 gctccacaaa tgaggaaagt accattttgg actattcaat tgtcaaagaa caaataaaaa
    21121 aaatcttcgc attttcacac tctatgaaat tgaggagatt attttctaaa gcgaatttta
    21181 tcaggaaaat ccgtcaatcc caataggtag tctgtactga catcgtaaaa gtttgagaga
    21241 gttaccaata tatctgctgt taacgtatgc tcaccccgtt caattttagc ataagctgag
    21301 tctgtaaacg aaagtatttt agctatttgt ttttgggtca aatcgtgatc ttccctcaaa
    21361 tctctcaaac gtctgtacat ctagctttct cctgagaaaa gtataatata taaaactaag
    21421 aaatcattca aagtgtccaa actggacatt ttgaactaaa attaatttat taaacatatc
    21481 tcataagcat atctattata ggtaagacaa tattaagaaa gacggtcaaa atctattaac
    21541 cgtctaaaga tgttataagc tattaaaaaa tcagcagtaa tccggtaaca aaagtcacat
    21601 aattttgtta aggaagggat taatgatgtc cagattacta ctaaccagca aattgaaaaa
    21661 tggtcaacat gatatttcta atgtgaatct cttactttca gaacctaaaa gttgaataat
    21721 agccaccccc tacttatcaa taaaattttc cgttgcatta acagatgtat atagaccact
    21781 ccatggattt caaagcaatt aactagactt tatttgtcaa taaccacaaa attagattag
    21841 aaaaatcatt aaaaattaat tggagtcctt tgtgatgctt tttcaataaa agtaatactt
    21901 ctcaatattt taactgaact aaagaaatag cataatggta tcttgattgt attcttctaa
    21961 aaaggattgc ccttcacatt caactgtgat tgattaaatt ccaaaaatat attccaaagg
    22021 cgctctaaat tctctatatc agctattttt tatcatctat caacttctat catacctctt
    22081 caatagcgtg ctaaatatta gcgataatat cgtaatagat acaccaataa taaaaaaatt
    22141 aaaagtattg ttaggattta aaactactga gaaaaaaaca gtacctagtg gcataaaaag
    22201 aatagctacc gtaaagatga ttccaaatac tctgccaaga aactcattat ctacgtctct
    22261 ttgaacaata gagaaaaatt ggatattaaa aatggaaaga aatagactaa ataatgctgg
    22321 agtaaaggct aaaataatga cgttgcggaa catataatag atcggcgctg ttagcattaa
    22381 catcaaacct gaatatgcta aaaagagcat taaacgtttg cttgacaagg atttattgat
    22441 aaatccactt aatatcgcac caataaagcc accaatcgct tcggctgtta aaaaggttcc
    22501 atatagccca cttgaaatac ttccaaacat ttgattactg tatggcagca acaaattata
    22561 ggctgctagg aaaaagttaa caagtgctga aagggcaatt atagtgagaa tttgtttatg
    22621 actatataca tacgtaaatc ctatttttaa atcatcaaag attcctctta tcgtcatatt
    22681 ctcttttgta tccacctcct catttacagg agtaatgaag aaaattagtg aggcagcaat
    22741 taaaaacgat aatccatcta gtaataacac accatgtatt ccaagtaact tatataagaa
    22801 aattgcaatc ataggaattg ttactttaat cacagtactt gttgtttcta gcaatgaatt
    22861 aagttatgat atactgtcct tttttacaat ttctttcgta aaagctttgt atgatggccc
    22921 tgaaaaagca ctcataaaag ccaaaatgac atttgttatg actatcgcat aaaccaacca
    22981 tttttcttgg gatataaatg aaagagttat gcaagcaata ccacataaga tatttgtagt
    23041 aataataatt tttttccgct tgaaactatc tgcaataact ccaccaaata aattaaatag
    23101 aacacctatc atactttcta atgattgata aattgcaacc actgatagag atgttggatt
    23161 aagaccagca agaaaggtat tattggcgaa atcaaacatg atatctccga ttcgagatat
    23221 catcctacta gctacaatgg atagaatatt gtgatgttct tctctaatca ttttattctc
    23281 ccgaatcagt aatcacatat ttaaactttt gtgatatgtg cttaagttca tctaaccttt
    23341 tctcaaattc acaactattt ttgcaattaa attggaccaa cattgaattt tcgactacat
    23401 tttcagatac tttatagtaa gtatttggtt taataaatat gtacactttt tttgcccaag
    23461 ccaattcttt ttcatcaggt acctcgataa ccttaccttg ctttctatat aaagcaaacg
    23521 ttgctgagat attagcaggt ctagaaatca ctttagaaaa atttattttt ttcaatcctt
    23581 gtgaattagt caaaatatcc caatattctt taattacatc aactccatga ctatcctcaa
    23641 ttaactgggg aatatctccc cctccaaatc tttttccaac ttcacaaaag actattttac
    23701 cagttgataa ttcaaggaac cattcaaaat gaaaaggggt tatttcagaa ttgatagaaa
    23761 aaacattcaa aactttgcga cattcttcca atgctttttc tatgtattca attttttcac
    23821 tatcattata taacgaacta gtccttacaa gataatatcc actagaactt aaggtattga
    23881 acaatagttc ctcatattcg tgaacataaa atcgcttaat ctcacttcca attgaataac
    23941 catcacatgt tatcatgtta tcgatatcaa tgtattcctc tataatatag tttttttcaa
    24001 aatacactga atcaattttc tcgttagggt aaactttttt tattccatta cttcctgctt
    24061 catttctagg ttttaaaatt gcagcagaag atttacaatt attccaaaaa acacgtaaat
    24121 cattttctga ttctaaaagc ctaaaatacg gttgatttac tactccaact aaaaatgaac
    24181 gcatgaagta tttgtcttta aataataaat tagacacaga gtgagtattt ttttctacaa
    24241 aatgatcatt caaaaaacct actatatcca tgtcttcctc actcaaggtt gtaatactct
    24301 caacttctgt attttgactt atccttctaa tttctaagat gatatttggt agaataaaat
    24361 cttctaaaaa aatgacctta ggtagattat ttccttcagc tagataatct tcatattttt
    24421 ttctttgaac ctcaggtgca ataattacta catttctgtt atacagatat tttagtttaa
    24481 caacccgtgc agaatatcta aataatacta tatgcatgtt aatcccaatc ctttcaatta
    24541 ttagtcatca tatccatttg gatgtttctg ttgccatttc cacgtatctt ggcacatttt
    24601 cataatatca taccttggct tccatcccag tagctcttct gcttttgaaa tatctgcaat
    24661 tgaaacgtcc atatctcctg ctctccttga agttatctta tatggaatat acgagcctat
    24721 gacactctct aagctgtgta ggatttcaaa tacactaaaa ccaacaccac ttcctaaatt
    24781 gattacttca tataaacctt catctgtatt aaaaatatac tctaatgctt ttctgtgtcc
    24841 gtatgctaaa tcgttaacgt gaacatagtc ccttatacaa gtcccatcag gagtactgta
    24901 atcaactccg aatatattta aatatggtaa ttttccaatt gcaacttgtg taatgtaagg
    24961 aacaagatta ttcggaattc catttggatc ctctcctaaa tcaccacttt catgtgcacc
    25021 caatggatta aaatacctca gacaaacaat tttccaattt gaattcgaaa taaacaaatc
    25081 atttaaaagt acttctatat actgttttgt tctcccatac gggtttgaag cttttaatgg
    25141 attagtctca tagaatggca tgataggagt actttcgtat acagtagctg atgaactaaa
    25201 cacaaaatta aataccttat attttttcat tagttttaaa atatttatag ttgataataa
    25261 attattttca taatacttca atggttcaac cacggattct ccaacagctt tataccctgc
    25321 aaaatgaatt actccatcaa aattatgtct cttaaaaaca ttttccaatt tttcttcatt
    25381 ttttaaatca attttataaa aatgaagatt tctactcttc ttggatatct gcttaataga
    25441 ctcaataact tttttcttag agttactcaa atcatcaatg attgttactt cataattatt
    25501 atctaacaag tccaaaactg tatgtgatcc tatgtatcct gctccacctg ttattaataa
    25561 tgatttcatg ctaatttacc tccatattct ttataccatt aatttgaaat ttatcttggc
    25621 taaaaattac cctatttgat tttgcttcac ttccaagaaa gttaccgata gaaatttctg
    25681 gaaattcaaa aatctttcta gactctaatt tatatttgtc tatgtctaac aaagtatatt
    25741 ttccatattg attaaccaga ttggaattat taaacaagat caagggatag ttatactccc
    25801 ttggtaattc tgctgtaatg attgaatttt gatttttaaa ttcgaagtta aattcacaaa
    25861 tcccttccct aaaaaaatga agctctgcat catcaaatac atagttacag tccaattcct
    25921 tatgaaaacc tagataaaat cctcttatta acgaataggg atttgaaaca tatgatacaa
    25981 ccggaaaatt aaaataatct tctccaatac aaagaggtat cttaaagatt atttctgtat
    26041 ataagatttc attattttca ttaatttctg aatacatatc agaaaaggta agatagaatg
    26101 attctactga ttgtagttgt cgatacaatt cttgatctag agacttaaca tctgggtata
    26161 atacactagc atcaactgct ttatttagtt taacttctag agttatatta ttacctttaa
    26221 atttatttgg taatcttatc atagttaccc tcccacttta atttttaata ttttagaaac
    26281 tattttgtca aactcttcaa tagaaagtga agtatcaata aatggaatat ctgtaaaata
    26341 tctaacctca tctaatttat gattaatttt tatatgtaaa ttctctccga ttaagtatct
    26401 atatacttca tttgttattc catacctatc actcaagata tctctagggt acttttgaat
    26461 taactttgga tattttttag taatattgtc aatttccttc attaaaaagt agatataatc
    26521 atttctcaat aaatgattta ctttcgttat atcaagtttg gtaattactg agtataaagc
    26581 gaattttttt agtatttttt tcactgtgtg ccctttataa tttcctgaaa tttcaatatt
    26641 tttagaggat aattgaataa gacaatccaa caaggaaact actcgaatat tttcttggct
    26701 atcaataaat tctagaaaca agctttctat attgaaatta gaggtattt
//
LOCUS       DBERMM010000025        25513 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.025, whole genome shotgun sequence.
ACCESSION   DBERMM010000025 DBERMM010000000
VERSION     DBERMM010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 25513)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25513)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25513
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.025"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(1..323)
                     /locus_tag="ACL8AS_001328"
                     /pseudo
     CDS             complement(1..323)
                     /locus_tag="ACL8AS_001328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(385..834)
                     /locus_tag="ACL8AS_001329"
     CDS             complement(385..834)
                     /locus_tag="ACL8AS_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HGS1229178.1"
                     /translation="MTLTTFLLQAVASFLAIITFLIVLNVQRSMLLPGGILGMTVWLI
                     YLLLKEPTNVIVATFIAAIIGSCVSQILSILYKTPAVVFILAILAPLVPGYLSYRTTA
                     FFVTGDYNKALASATLVVMLALVISIGMASGTVILRLYHYIKTHRVS"
     gene            complement(836..1594)
                     /locus_tag="ACL8AS_001330"
     CDS             complement(836..1594)
                     /locus_tag="ACL8AS_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HGS1229179.1"
                     /translation="MEESKELNAVIDVIMLAGTILLKSGSEIHRVEDTMIRIAHSQGI
                     VDCNVLAMPAAIFFSIENTNISRMKRVTSSSYNIEKVCDVNQISRQLVGGQIDLETAF
                     KQLTALQAQPLPYTKLQVTLAATFSAPFFSVMFSGNIYDALGAGVATLFGFAFSLYVE
                     KFIRIPFVTAFAGAFVFGIIAQFWARYTGFPSTADLIIAGAVMPFVPGIALTNAVRDI
                     MTNHINSGMSKMFESLLITLALGAGTSVALVLMN"
     gene            complement(1709..3688)
                     /gene="stkP"
                     /locus_tag="ACL8AS_001331"
     CDS             complement(1709..3688)
                     /gene="stkP"
                     /locus_tag="ACL8AS_001331"
                     /EC_number="2.7.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000614538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine-protein kinase StkP"
                     /protein_id="HGS1229180.1"
                     /translation="MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVL
                     RTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYI
                     KEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPKNILLTPDGTAKVTDFGIAVA
                     FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAV
                     TIALQHFQKPLPSVIAENPSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYN
                     RRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQ
                     APKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANF
                     EIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSD
                     VIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKAT
                     TIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVS
                     KPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAE
                     GMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP"
     gene            complement(3685..4425)
                     /locus_tag="ACL8AS_001332"
     CDS             complement(3685..4425)
                     /locus_tag="ACL8AS_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA];
                     GO_process: GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HGS1229181.1"
                     /translation="MGISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAG
                     NIASEMAVTDLGVAWVDTQIDTVNEVREWFAHYLEIENQKIHQLGQDEAYRGMGTTLE
                     VLAIIDNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAEAHPQKN
                     IITQSIGQKDEIQPDFGTVILESGDYLLLNSDGLTNMISGSEIRDIVTSDIPLADKTE
                     TLVRFANNAGGLDNITVALVSMNEEDAE"
     gene            complement(4440..5753)
                     /gene="rsmB"
                     /locus_tag="ACL8AS_001333"
     CDS             complement(4440..5753)
                     /gene="rsmB"
                     /locus_tag="ACL8AS_001333"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0001510 - RNA methylation [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HGS1229182.1"
                     /translation="MTKVETARSLALAVLEDVFVNQAYSNIALNKHLKGSQLSAADKG
                     LVTELVYGTVARKLTLEWYLSHFIEDRDQLDSWLYVLLLMSAYQLRYLDKIPDHAVVN
                     EAVELAKLRKKGSEKLVNAVLRRILREGWPDIASIKRKNKRDSIAYSLPVWLVAKLKE
                     EYGEERAKAIFESLLVRNKASIRVTDLSRKEEIQALLEANNSLLATTGLVKEQGHFAG
                     HNLFADGAITIQDESSQLVAPTLDLQGDERVLDACAAPGGKTAHIASYLTTGQVTALD
                     LYDHKLDLIQENAQRLGVEDRVQTQKLDARKVHEFFDQDSFDKILVDAPCSGIGLLRR
                     KPDIKYNKETADFASLQEIQLEILGSVCQILGKGGIITYSTCTIVSEENFQVVKAFLE
                     SHPEFEQVKLEHECKDIMKDGCILITPELYGSDGFFISQFRKISD"
     gene            complement(5746..6681)
                     /gene="fmt"
                     /locus_tag="ACL8AS_001334"
     CDS             complement(5746..6681)
                     /gene="fmt"
                     /locus_tag="ACL8AS_001334"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004479 - methionyl-tRNA formyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0071951 - conversion of methionyl-tRNA to
                     N-formyl-methionyl-tRNA [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HGS1229183.1"
                     /translation="MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKV
                     IQETPVKQAAKEAGLSIYQPEKLSGSPEMEELMKLGADGIVTAAFGQFLPSKLLDSMD
                     FAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDED
                     NVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKPEEEKLDWNKTN
                     RQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSICKKELIVATAEGA
                     LSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD"
     gene            complement(6694..9090)
                     /locus_tag="ACL8AS_001335"
     CDS             complement(6694..9090)
                     /locus_tag="ACL8AS_001335"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HGS1229184.1"
                     /translation="MALAKIIVDVPLMQTDQPYSYRIPEEFEGMLEVGMRVHVPFGKG
                     NRLIQGIVLGLESQSDGEEMEQDLKDIAEVLDFSPVLTPEQLWLAEELRKSVFSYKIS
                     ILKAMLPGFLNSSYDKILYPLEGLSQEERVRLFGSEDSLAFSSLDLGKQAEMMRLTRK
                     GLLGLEYQAVDQKKVKTQSWYEVDHAQLEGVEISTRAKKKLELRDYLLSHPESASLAS
                     LLESYSREQVNFFVDQGAVTIVQKEVRRSAAYFEGIEASRPLELNPEQRQARDAVVSS
                     IGSSQPPFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFG
                     DKVAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEAAYK
                     QDSNPRYHAREVAILRAQYNQATLVLGSATPSLESRARAGKGVYQHLRLTQRANPLAT
                     IPEVQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSFVMCRECG
                     TVDTCPNCDISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKSRSIRYYGTGTQKAYDEL
                     AELFPQARILRMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDFPNVTLVGV
                     LNADTALNLPDFRSSERTFQLLTQVAGRAGRAEKAGQVLIQSYNSQHYAIRFAKDQDY
                     EGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPILG
                     PTPKPIARTHNLYHYQILIKYRLEDELGPTLNQVLALTQERENSELRLSIDHEPQQFL
                     "
     gene            complement(9156..9470)
                     /gene="rpoZ"
                     /locus_tag="ACL8AS_001336"
     CDS             complement(9156..9470)
                     /gene="rpoZ"
                     /locus_tag="ACL8AS_001336"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HGS1229185.1"
                     /translation="MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSE
                     KSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEEKKIKEQIAKEKEDGE
                     KI"
     gene            complement(9495..10121)
                     /gene="gmk"
                     /locus_tag="ACL8AS_001337"
     CDS             complement(9495..10121)
                     /gene="gmk"
                     /locus_tag="ACL8AS_001337"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004385 - guanylate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006163 - purine nucleotide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HGS1229186.1"
                     /translation="MADRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQ
                     RPGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLE
                     IEVQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALM
                     REYDYAIVNDQVPLAAERVKCVIEAEHFCVDRVIGHYQEMLPKSPTTR"
     gene            complement(10251..11864)
                     /locus_tag="ACL8AS_001338"
     CDS             complement(10251..11864)
                     /locus_tag="ACL8AS_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HGS1229187.1"
                     /translation="MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQ
                     EATNLRGQAEREADLLVNEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELK
                     QIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE
                     LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRI
                     AGEYVAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFD
                     PIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHP
                     DLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAID
                     HEVEGSHVEIGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGA
                     RSESLESYIKRLHDLEEIANGFEGVQTSFALQAGREIRIMVNPGKIKDDKVTILAHKV
                     RKKIENNLDYPGNIKVTVIRELRAVDYAK"
     gene            complement(12208..14955)
                     /locus_tag="ACL8AS_001339"
     CDS             complement(12208..14955)
                     /locus_tag="ACL8AS_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HGS1229188.1"
                     /translation="MEENYNLSITQIKNSIKENSLVLFVGAGISANSNLPTWGELIQS
                     LKKELNIPEERTDSPLRIAQYYYDTFGKNQYTKKIEEIFFKKGLSKPNELHKLIEKIA
                     PKHIITTNYDSLLESQFESGLLKYNVVAEDKDIPYTSSERYLIKMHGDFSKKNIVLKE
                     DDYLDYHLNFPMISTLIQSLIMNHTLLFVGYSLSDSTFNSIFRMIQNTFKLDAKNAYF
                     YTPEEPSMIIREYYKKQGIFIISNEENLGQETSEKQNKLYCRTKDFLEVLSENRSQDV
                     NNADDLWNQLAFLDRLSFIDAKDFSRYSDLKKRALNWDDEYCWFGNDQLRFEIDGHEE
                     LRIMVSKKSLLNRFLDMEIGEPRDLKGNRFLSKAFKLYEEKQYSLAKAKFRELANIAF
                     RQKDYFNFLVCEFNFQQIQIIDRYEKTPSYAEPLYDGELSELTEQILNSVTGDEKKII
                     EFFRDSILNFNFLYRKLETINELFDEIREEHESYRRGGWSANNHLFNAEFTVKNLYNF
                     LKLNCLCVEHYKIYKSIINRYLEILLLSYDNSYVNPDSSIFDRTSSWLKNLDLDDVQL
                     ILPNIDFKVVNLYFRNYSFGKIKVTEEAKDYLLNRITYLQERLEITEDENLRELKNML
                     IFLPLVDDIDIEKVIEILNNQTLYYNWREEFRRIIKIVLDNMDVIDKDSLKSKIIGIV
                     NKHLNEILEKNFSLYNSVYPLYSQLLEYCSTDQETAIIVLEKFNTDILRIKYKNDDIK
                     NIIEYSDLICHLFKYFEKDIKDDILDTLKVYEESENIIYHKVIDLMSYNVYDFPQIQN
                     KIYHYLIKRINDKRVEGVKTFPDPREKSVSDLYNLSRKGYFSDFEILKDIEEDIRGLY
                     PEVDWTWFHDRSDDVIHRLLEHRTPNNIKTYFSKNEEDNKLINEYILKAFDEDKLILK
                     K"
     gene            complement(15303..16400)
                     /locus_tag="ACL8AS_001340"
     CDS             complement(15303..16400)
                     /locus_tag="ACL8AS_001340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HGS1229189.1"
                     /translation="MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAI
                     VDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVDILDRLGIDSLVFGTEEVRD
                     YQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYA
                     KAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQA
                     SKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRY
                     TKARVRRLLTYILVQARESDLPEGIHVLGFTEKGRQHLKYLKGQVSLVSRIGKEPWDV
                     MTQKADQIYQLGNPSIAEQNFGRVPIRIETN"
     gene            complement(16410..17150)
                     /locus_tag="ACL8AS_001341"
     CDS             complement(16410..17150)
                     /locus_tag="ACL8AS_001341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HGS1229190.1"
                     /translation="MATYETFAAVYDAVMDDSLYDKWTNFSLRHLPKTKEKKKLLELA
                     CGTGIQSVRFSQAGFDVTGLDLSADMLKIAEKRATSAKQKIAFIEGNMLNLSKAGKYD
                     FVTCYSDSICYMQDEVEVGDVFKDVYNALNEEGVFIFDVHSTYQTDEVFPGYSYHENA
                     EDFSMLWDTYEDEVPHSIVHELTFFIKEADGSFSRHDEVHEERTYEILTYDILLEQAG
                     FKSFKLYADFEDKEPTETSTRWFFVAQK"
     gene            complement(17259..17612)
                     /gene="rsfS"
                     /locus_tag="ACL8AS_001342"
     CDS             complement(17259..17612)
                     /gene="rsfS"
                     /locus_tag="ACL8AS_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0017148 - negative regulation of
                     translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HGS1229191.1"
                     /translation="MNEKELLELVVKAADEKRAEDILALDVQDLTSVTDYFVITSSMN
                     SRQLDAIAANIREKVAQAGFKGSHVEGDAAGGWVLLDLGAVVVHIFSEEMRAHYNLEK
                     LWHEANSVDISEALA"
     gene            complement(17625..18125)
                     /locus_tag="ACL8AS_001343"
     CDS             complement(17625..18125)
                     /locus_tag="ACL8AS_001343"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase family protein"
                     /protein_id="HGS1229192.1"
                     /translation="MKTAFIIIDVQNVLVETGFQTKSLLEKISYLQNQARSKNIEIIY
                     VQHIENSEAQTSEDWQLSALLNRKPAEKVFQKKYNSIFKETGLKEYLDKQGIEKLVLC
                     GMQTEYCVDTSVKVAFEYGYQLIVPEGAVTTFDGDDIPAETINEFYEDIWEEHFADVL
                     DYKHIF"
     gene            complement(18126..18719)
                     /gene="yqeK"
                     /locus_tag="ACL8AS_001344"
     CDS             complement(18126..18719)
                     /gene="yqeK"
                     /locus_tag="ACL8AS_001344"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HGS1229193.1"
                     /translation="MSYQDYINCSREALLEKMAELLPEKRLTHCLGVERAAMELAQRF
                     GVDVGKASLAGLLHDYAKKLSDQEFLDLIDRYQLDFDLKNWGNNVWHGMVGIYKIQED
                     LDLHDSEILRAIEVHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIASLSLNKA
                     VAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKED"
     gene            complement(18719..19348)
                     /locus_tag="ACL8AS_001345"
     CDS             complement(18719..19348)
                     /locus_tag="ACL8AS_001345"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HGS1229194.1"
                     /translation="MTIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVA
                     DQVRQQLGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIDGLVIETIELERK
                     GISYTYDTMKILTEQHPDTDYYFIIGADMVDYLPKWYRIDELVDMVQFVGVQRPRYKA
                     GTSYPVIWVDVPLMDISSSMVRDFIAQGRKPNFLLPQPVLDYIEKEGLY"
     gene            complement(19400..19711)
                     /gene="yhbY"
                     /locus_tag="ACL8AS_001346"
     CDS             complement(19400..19711)
                     /gene="yhbY"
                     /locus_tag="ACL8AS_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome assembly RNA-binding protein YhbY"
                     /protein_id="HGS1229195.1"
                     /translation="MSLTSKQRAFLNSQAHTLKPIIQIGKNGLNDQIKTSVRQALDAR
                     ELIKVTLLQNTDENIHEVAEILEEEIGVDTVQKIGRILILFKQSSKKENRKISKKVKE
                     I"
     gene            complement(19925..21031)
                     /gene="yqeH"
                     /locus_tag="ACL8AS_001347"
     CDS             complement(19925..21031)
                     /gene="yqeH"
                     /locus_tag="ACL8AS_001347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391231.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="HGS1229196.1"
                     /translation="MEEILCIGCGATIQTTDKAGLGFTPQSALEKGLETGEVYCQRCF
                     RLRHYNEITDVQLTNDDFLKLLHEVGDSDALVVNVIDIFDFNGSVIPGLPRFVSGNDV
                     LLVGNKKDILPKSVKSGKISQWLMKRAHEEGLRPVDVVLTSAQNKHAIKEVIDKIEHY
                     RKGRDVYVVGVTNVGKSTLINAIIQEITGDQNVITTSRFPGTTLDKIEIPLDDGSYIY
                     DTPGIIHRHQMAHYLTAKNLKYVSPKKEIKPKTYQLNPEQTLFLGGLGRFDFIAGEKQ
                     GFTAFFDNELKLHRSKLEGASAFYDKHLGTLLTPPNSKEKEDFPRLVQHVFTIKDKTD
                     LVISGLGWIRVTGIAKVAVWAPEGVAVVTRKAII"
     gene            complement(21034..21561)
                     /locus_tag="ACL8AS_001348"
     CDS             complement(21034..21561)
                     /locus_tag="ACL8AS_001348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008962 - phosphatidylglycerophosphatase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="HGS1229197.1"
                     /translation="MAIENYIPDFAVEAVYDLTVPSLQAQGIKAVLVDLDNTLIAWNN
                     PDGTPEMKQWLHDLRDAGVGIIVVSNNTKKRVQRAVEKFGIDYVYWALKPFTFGIDRA
                     MKEFHYDKKEVVMVGDQLMTDIRAAHRAGIRSILVKPLVQHDSIKTQINRTRERRVMR
                     KITEKYGPITYKKGI"
     gene            complement(21576..22484)
                     /locus_tag="ACL8AS_001349"
     CDS             complement(21576..22484)
                     /locus_tag="ACL8AS_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HGS1229198.1"
                     /translation="MVLEKQLGNGCTWIDLDLGKLNKLEDLSEIYGLDKETIEYALDR
                     NERAHMDYHRESGTVTFIYNVLDVKKDKAYYETFPMTFIVEYRRLITISNTKNAYVIE
                     QMTRYLESHDTLSIYKFLFASLEIISNAYYPVIEQMDKSRDEVNDLLRQRTTKKNLFA
                     LSDLETGMVYLTAAAKQNRILLEHIQGHALYRSFDEIEREQFDDAMIEAHQLVSMTDL
                     ISQILQQLSASYNNILNNNLNDNLTTLTIISVLLAVLAVVTGFFGMNVPLPLTDEPHA
                     WLYISLASAGLWIVLSLLLRKIAKKS"
     gene            complement(22541..23101)
                     /locus_tag="ACL8AS_001350"
     CDS             complement(22541..23101)
                     /locus_tag="ACL8AS_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel domain-containing
                     protein"
                     /protein_id="HGS1229199.1"
                     /translation="MQKFIQAYIEKLDVTTIIENILTKVISLLLLLIVFYIAKKMLHT
                     MVQRIVKPSLKMSRHDVGRQKTISRLLENVFNYTLYFFLLYCILSILGLPVSSLLAGA
                     GIAGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNGPITVSGKVVSVGIRTTQ
                     LRSEEQALHFVPNRNITVVSNFSRTD"
     gene            23240..24449
                     /gene="sstT"
                     /locus_tag="ACL8AS_001351"
                     /pseudo
     CDS             23240..24449
                     /gene="sstT"
                     /locus_tag="ACL8AS_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713440.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015293 - symporter activity [Evidence
                     IEA];
                     GO_process: GO:0015826 - threonine transport [Evidence
                     IEA];
                     GO_process: GO:0032329 - serine transport [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine transporter SstT"
     gene            24517..25470
                     /locus_tag="ACL8AS_001352"
     CDS             24517..25470
                     /locus_tag="ACL8AS_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HGS1229200.1"
                     /translation="MSISQRTTKLILATCLACLLAYFLNLSSAVSAGIIALLSLSDTR
                     RSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLYLAFYVPLAYKMGWEIGITPS
                     TVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLK
                     DILQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMR
                     QRQSRILRNMAQQINTCHLAASESLILAQLFSKIAGQLSQTNPASDLLDEIERYLEVF
                     RNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYRQ"
BASE COUNT         7054 a         5796 c         4747 g         7916 t
ORIGIN      
        1 tgaacaactt catatcatga caatagttca cagtgatatc caaagaaaca attctccctt
       61 gacttgtgac aatcgcttga gtcttcatag cgtgaaattt ctttttacca gaatgattcg
      121 ctaattcttt ttttagggcg attgattttt actttcgtcg catcaatcat taccgtgtcc
      181 tcagaactga gaggagttct tgaaatcgta acaccacttt gaacaagagt tacttcaacc
      241 cattggctcc gacggagtaa gttgctttcg tggataccaa aatcagccgc aatttcttca
      301 taagttcgat attctcgcac atatagaaag cgttgttaat ttatttatct catttttcag
      361 aaaattcttt tatttctgta aagtctacga tactcgatgt gtttttatat aatgatacag
      421 tctgagaatc actgttccgc tagccattcc aatagagatt accagagcca acatgacaac
      481 caaggtcgca cttgccagtg ctttattata gtcccctgtc acaaaaaagg cagttgttcg
      541 gtaggagaga taacctggaa ccagcggtgc caaaatggcc aagataaaga ccacagcagg
      601 tgtcttataa agaatactta aaatctggct gacacaagaa ccaataatgg ctgcaatgaa
      661 ggtagctaca atgacattgg tcggttcctt gagcaagaga tagattagcc agacagtcat
      721 gcccaaaatc cctccaggca agagcataga ccgttgcaca ttgagtacga ttaaaaaagt
      781 gataatggca agaaaacttg ctactgcttg taataaaaag gttgttagtg tcatattagt
      841 tcatcaatac caaggcgaca gaagttcctg cccctaaagc gagggtaatg agcagggatt
      901 caaacatctt actcatacca gagtttatgt ggttggtcat aatatcacgg accgcattgg
      961 tcaaggcaat acctggtaca aacggcatga ccgcaccagc tataatcaaa tctgccgttg
     1021 aaggaaaacc tgtgtagcga gcccaaaact gggcaattat cccaaagaca aaggctccag
     1081 caaaggctgt cacaaaggga attcggataa atttttccac atagagggaa aaggcaaaac
     1141 caaataaggt cgccactcct gccccaagtg cgtcgtagat atttccgcta aacataactg
     1201 aaaagaaagg agcactaaag gtcgcagcca gagttacctg caacttagta tagggaaggg
     1261 gttgagcttg caaggccgtc aattgcttaa aggctgtttc taagtcaatc tgccccccaa
     1321 ctagctgacg agaaatctgg ttcacatcgc agactttttc gatgttataa gaagaggagg
     1381 tcacgcgctt catgcgcgaa atattggtat tttcaataga gaaaaagata gcggcaggca
     1441 tggcaaggac attgcaatcc acaatcccct gcgaatgcgc gattcgaatc atggtatctt
     1501 ctacacgatg gatttctgag ccacttttaa ggagaatagt ccccgctagc ataatcacat
     1561 caatgacggc atttaattct tttgattctt ccatgctttc ctccttttat caactccctc
     1621 tattctatca caaatccgga ctcaaaaaaa atctttgcca tgaaatcatg acaaagattg
     1681 attactcatt ttgattatcc atctgctttt aaggagtagc tgaagttgtt ttaggtttgt
     1741 agattgaaat cttgactcta gtcttattga ggtctacctt ttcacctgct ctaggacttt
     1801 gttcaacaac catgccttct gcactacctg caggcgctgt cgtcacttct acaacttcta
     1861 tattagcttc cttaatccca acaatttgaa tcaaattgtt cttagtaaac tccaagctgg
     1921 aaccaatgta actcggcatg gcaacacttg taactttttt agctactgtc aagacaattt
     1981 gagtaggttt actcacatca taagtcgttc cggcacctgg actttgtttc ataatcgttc
     2041 ctggttcgct ttcgctggac tcttcttcct ctatcttaat caaattctca ggaaccttct
     2101 tctgcttgag ttctgagatt acttctgtag agttccgtcc aatatagttc cctaattgaa
     2161 tcgtcgtagc ttttttagct actgtcaaaa caatttgagt tgccttgctc aagtcatagg
     2221 tcgtaccttc tggtagactt tgcttcagga ccgttccagc ctcactctca ttcgactctt
     2281 cttcctcaat tttaatcaaa ttatctggaa cttttttctc ttttaattcc gcgataacat
     2341 cagaagattt ccggccgaca taattactaa tttggaagga ttgtttgcct gatgagacaa
     2401 ccagattgat tttcgttcct tcttttcgac cagttccagc gccaggatct gtacggataa
     2461 tccgcccttc ttccaccttt tcactagcct ctgtcttctc ctcaccaatc tcaaaattgg
     2521 cttttttgag cgttgccttg gcctctgcaa ctgtctgacc tgccacatct ggaatggcaa
     2581 tggttgcagg agttctggat agtatccaaa taagagaagc tgccaccaat acaaggctgg
     2641 ccaacaaaat caggtaacgc atcttaaatc tatgtttttt cggtgcttgt ggttggtaag
     2701 tttcctctgt cacagcctgg cttgggtttt tgattgattt gtgttctgtc tgcgcttgaa
     2761 ccttaggaat agatgtcaag gtactctgag aaaccttcgg caaggtcttg gtatctgcct
     2821 tgctcgtttc atcaaagatt aacttacttt catttctacg attgtaggac aagctactag
     2881 acaagtccac atacatctct gaaaccgagc ggtagcgatt ggtcaacttt ttagcagttg
     2941 ccttgataat aacattttct aaagcctgag gtacagatgg attttctgca ataacggacg
     3001 gcaggggttt ctggaaatgc tggagggcaa tggtcaccgc gctatccccg tcataaggga
     3061 tatggcctgt caacatctca tagaaaataa tccccatggc atagatatca ctctgcacag
     3121 tcgccttaga accacgcgcc tgctctggtg acaagtaatg aactgagccc aacatcgagt
     3181 tagtctgggt cagacttgtc tctgcaaagg ctacagcaat cccaaagtct gtgaccttgg
     3241 ccgtcccatc tggtgtcaaa aggatatttt taggtttcaa gtccctgtga acaattcctc
     3301 gagtatgggc caagcgcata gccaagagaa tttgtcccat gatacggact gcttcttcat
     3361 tagaaagagg ataatgttcc ttgatatagc gtttgaggtc tagtccagca acatactcca
     3421 ttgcaagata ctgttgaccg tcttcctcac caatatctgt tatccgaacg atatgaggat
     3481 ggtctagatc tgccatagct ctcgcttcac gctgaaaacg agctacagct atcgggtccg
     3541 tctggtagtt ggtcctcaga accttcactg ccacttcttc cccatctaag attaagtctt
     3601 tggctaggta gacatccgcc atacctcctc gaccaatctg tttgacaatc cgatagcgtc
     3661 cggcaaaaat cttgccgatt tggatcattc tgcatcctcc tcgttcatag aaacaagggc
     3721 aaccgtaatg ttgtctaaac ctcctgcatt gttagcaaaa cgaacaagtg tctccgtttt
     3781 atctgctaaa ggaatatcac tggttacaat atcacgaatc tcactgcctg aaatcatgtt
     3841 ggtcaagccg tcactattga gcaagagata gtcacctgac tcaaggataa ctgtcccaaa
     3901 atcaggctga atttcatctt tttgcccaat agactgggtg ataatatttt tttgcggatg
     3961 agcttctgcc tcttctggtg tcaattgacc agccttgagc aattcattaa ccaaagaatg
     4021 atcactcgtc aactgatggt attcttctcc acgaatcaag ccgatacgcg aatcaccaat
     4081 atgagcatag atagcctgat tatcaataat agcaaggact tccaaagtag ttcccatgcc
     4141 tctgtaagct tcatcctgac caagctggtg aatcttttga ttttcaattt ctaggtaatg
     4201 ggcgaaccat tcacgcactt cattgactgt atcgatctga gtatcaaccc aagctacacc
     4261 caggtctgtg accgccattt cactagcgat attccctgcg cgatgacctc ccatcccatc
     4321 agctaaaata atcatggtac gtccagctct attgacatag tggttgacat agtcttggtt
     4381 atttgttcgt ttctgaccaa catctgttaa taatgaaatt cccatgtgtc agttccttcc
     4441 taatccgata tcttgcgaaa ttgactgatg aagaatccat cacttccata caattcaggt
     4501 gtaatgagga tacagccgtc tttcatgata tccttacatt catgttctag ttttacctgc
     4561 tcgaactcgg gatgactctc taaaaaggcc ttaacgactt gaaaattctc ctctgagacg
     4621 atagtgcagg tgctataagt tattatacca cctttgccta gtatttgaca aacactacct
     4681 aatatttcta actgaatttc ctgcaaggac gcgaaatctg ccgtttcttt attgtatttg
     4741 atatctggtt ttcggcgcaa aagaccgatt cctgaacaag gagcatccac caaaatctta
     4801 tcaaaggaat cctggtcaaa aaactcatgc acctttctgg catccaattt ttgagtttga
     4861 acccgatctt caactcccag acgttgggca ttttcttgaa ttaaatccaa cttgtggtcg
     4921 tacaagtcca gagcagtaac ctgacctgtc gtaagataag aggctatatg ggctgttttc
     4981 ccacctggag ccgcacaggc atcaagcact cgctcatcac cttgtaaatc aagcgtcgga
     5041 gcaaccagct gactggactc gtcttggatg gtaatggctc catccgcaaa caaattatgc
     5101 cctgcaaaat gcccttgctc cttaaccaga ccagtggttg ctaaaaggga attattcgcc
     5161 tccaacaagg cttggatttc ctcttttcga cttaggtctg ttacacgaat actggctttg
     5221 tttcgcacta acaggctttc aaagatggct tttgctctct cctctccgta ttcttccttg
     5281 agtttggcaa ctagccaaac tgggagagaa taggcaatgg agtcacgctt gttttttcgc
     5341 ttgatgctag caatatctgg ccagccttca cgcaagatac ggcgaaggac agcgttgacc
     5401 aatttttcac tgcctttttt acggagtttg gccaattcca ctgcttcatt gaccacagca
     5461 tgatctggaa tcttgtccaa atagcggagt tggtaggcac tcatgagaag aaggacatag
     5521 agccagctgt ctaactggtc tctgtcttcg ataaagtggg ataggtacca ttccagagtc
     5581 agtttacggg ctaccgttcc atagactagc tcggtcacta agcccttgtc tgctgcagag
     5641 agctgactcc ccttgaggtg tttatttaag gcaatatttg aatatgcttg attcacaaaa
     5701 acatcctcta gcactgctag agctaaactt ctagccgttt ctactttagt caccaaatcg
     5761 ttctcctaca gtcaatgtac gtccaacccc gttgaggaag gaagcaatgt ccatcttagg
     5821 cttaccagct ggctgcactt gtttgaggga tagagcccct tcagccgttg cgacaatcaa
     5881 ttctttcttg cagatagaga gaatctcacc tggatttccc tgaccttcta ctggtagggc
     5941 ttcataaatc ttaaagcggt cgcccttaag aaaagtatgg gcaacaggcc aggggttcat
     6001 tccacgaatt tggttaaaga gttgacgatt ggttttgttc cagtccagtt tttcttcctc
     6061 tggctttata tttggagaga aggtaacctg actcgtatcc tgcggttcag gtttgatatc
     6121 accagcaata taggcaggca gagtgtccaa aagcaaatca cgaccaacta gcgccaattt
     6181 ttcaaacaag gtgccaacat tgtcctcatc tgtgatcgga atgctgcgac gagaaatcat
     6241 atctcctgca tccatttcct taaccatttc catgatggtc acaccagctt cctcatcccc
     6301 ttgaatcaag gcataatgga taggcgcacc accacggtgt ctaggaagga gggaggcatg
     6361 aacgttgaca gcaaagtcca tgctatcaag gagtttgctt gggagaaact gcccaaaagc
     6421 agcagtcaca attccatctg ctcctagctt cataagttct tccatctctg gacttccaga
     6481 taatttttca ggttggtaga tagatagtcc tgcttccttg gcagcctgct tgactggggt
     6541 ttcttggata acttttttac gaccaacagc acggtctggc tgggtcacaa cggctagaat
     6601 ttcgtaacgg tcatctgtca aaagtccttt taagactgtt gctgaaaagt cgggggtccc
     6661 cataaagatt agttttgtca tatcttctcc ttcttataaa aattgctgcg gctcatggtc
     6721 aatgctgaga cggagctcac tattttcccg ttcttgagtc aaggctaaaa cctggttgag
     6781 ggtcggcccc agctcatctt ctaaacggta tttaattaaa atctggtaat gatagaggtt
     6841 gtgggtacgg gcaatcggtt ttggcgttgg ccccagaatg ggactggtct ctgacaagcc
     6901 tgaccgcaaa atgttcatga cttcataggc acgtttgaaa acctcttctt ctttcttgtg
     6961 agaaagggta ataccaatcg tgaaatagta aggtggatag ccgagttgtc gtctgattcc
     7021 catttcatag gcataaaagc cttcgtaatc ttgatccttg gcaaatcgaa tagcatagtg
     7081 ctgcgaattg taggactgta tcaagacttg acctgctttt tcagcccgac ctgctcgacc
     7141 tgccacctga gtcaagagct ggaaggttct ctcagaagaa cggaaatcag gcagattcaa
     7201 ggccgtatcc gcatttagaa ctccgactag ggtaacattg ggaaaatcca aaccctttgc
     7261 aatcatctga gtaccaagta aaatatccgc ttcccctcgc ccaaactggt caagcaaggc
     7321 ttggtgactg cctttctttc gagtcgtatc cacatccatc ctcaaaatgc gagcttgggg
     7381 aaagagttct gctagctcat cataagcctt ctgagttccc gtcccatagt aacgaatact
     7441 gcggctctta cagttaggac agacctgagg aatatccttc gagaaaccac aataatggca
     7501 gttcatagtc ttggtatcca tatgcaaggt cagagaaata tcgcagttgg gacaagtatc
     7561 caccgtccca cactcccgac acatgacaaa gctagaataa ccacggcgat tgagcatgag
     7621 aaccacctgc tcttttttaa ccagacggtc ttggatagcc tctagcaaag gaggcgtaaa
     7681 gtttgacgtc tcattttgtc cgatatagtc tcgaaagtca atcacttgaa cctcagggat
     7741 tgtagccaaa ggattggcac gttgggttag acgtaagtgt tgatagacgc ctttgccagc
     7801 acgtgcccgg ctctctaagc tcggcgttgc agatccaagt accagagttg cttgattata
     7861 ctgagcccgt aaaatagcta cctctctggc atggtaacgg ggattgctgt cctgcttata
     7921 agccgcttca tgctcttcat caataatcat gacacccaga tttttcagag gagcaaagat
     7981 agcagatctg gcaccaacaa caacttgggc atcgccacgc tccaccttgc gccattcatc
     8041 atacttttca ccattggata atcctgagtg aagaatggct accttgtccc caaaacgtgc
     8101 tataaaacgc tcggtcatct gaggagtcaa ggaaatctca ggtaccagca aaatagctgt
     8161 cttgccctta tccagggcac cttggataat ctgcaagtaa acctcggtct tcccacttcc
     8221 tgtaatccct tgaagtagaa agggaggttg agaactgcca atagaactca caaccgcatc
     8281 acgcgcctgt ctttgttctg gatttaactc caaaggtcta cttgcttcaa ttccttcaaa
     8341 ataagcagcc gagcgtcgaa cttccttttg gactatggta acagcacctt gatccacaaa
     8401 gaagttgact tgctctcgcg agtaggactc taacaagcta gccaaggaag cgctctctgg
     8461 atgagacagc agataatctc tcagttccaa ctttttcttg gcacgtgtag aaatctcaac
     8521 accttctaat tgggcatggt caacctcata ccaagactgg gtcttgacct tcttttgatc
     8581 gactgcctga tattccagac caagcaggcc ttttctagtc aaacgcatca tttcagcttg
     8641 cttacctaaa tccagagaag aaaaggctag cgaatcttct gaaccaaaca ggcgcactcg
     8701 ttcttcctga ctcaagcctt ccagaggata gagaatcttg tcatagctag aattcagaaa
     8761 tcctggaagc atggccttga ggatagagat tttgtaggag aagacagatt tgcgtaactc
     8821 ctcagccagc cagagttgtt ctggcgtgag aacaggagaa aaatccagca cctctgcaat
     8881 atcttttaaa tcttgctcca tctcttctcc atctgattgg gactccaaac caagaacaat
     8941 cccttgaatc aggcgattac ccttaccaaa aggtacatga acccgcatcc caacttccag
     9001 cattccctca aattcctccg gaatcctgta actatagggc tggtccgtct gcatcaaggg
     9061 cacatctacg ataatcttag ctagggccat cttctcacct cctccttgtc agtacattct
     9121 tgcaatagaa aaaataagat tgagtccccc caaccttaaa ttttttcacc atcttctttt
     9181 tctttagcaa tttgctcttt gattttcttt tcttcttctt ctttgcggcg tttttcttct
     9241 tcgatacggc gacgcactgc ttcacgtttt ccttctggat ctgggtgaat tgtaacgttt
     9301 cctgattcga tttcttctaa agcgcgaaga gttgattttt cagacttgaa accttgagtt
     9361 gctggggcac ctgcttccaa ttcgtgggca cgttttgctt ccaagattac gagtgaatat
     9421 tttgaaggaa ccttgtcgag caaggtatca atagagggtt ttaacatcat ttgcttgtac
     9481 ctattttcta aattttatcg ggtagttgga gattttggta acatctcctg atagtgacca
     9541 atgacacgat ccacacagaa atgttctgct tcaatcacac atttgacacg ttcagcagct
     9601 aggggcacct gatcgttgac aatggcataa tcatactcac gcatgagggc aatttcttcc
     9661 ttggcctttt cgattcgttg ggcaatcact tctgcactat ctgttccacg acctaccaag
     9721 cgatcttgca attcatccaa atctggtggt gtcaggaaga taaagacagc atctggaacc
     9781 tttttcttga cctgaagagc accctgaact tcaatttcaa ggaaaacatc gattcccttg
     9841 tccaaggttt cattgacata ggtcagagga gttccatagt agttaccgac atattctgcg
     9901 tattccaaca tctgtccttg acgaatcagc tcttcaaatt cttcacgagt acggaagaaa
     9961 tagtcaacac cgtccacttc tccaggacgt tgtgcgcgtg tcgtcatcga tacagagtat
    10021 tgaaattggt tttcagaact ctcaaaaatc tctcttctaa ccgttccttt tccaacccct
    10081 gaaggaccag aaaaaacgat tagtaagcct cggtctgcca ttgtgtctcc ttttagtcaa
    10141 tctgtgaaat aacatttctc tagaataatg gcaaaaagcc agattatcct ttacagtctt
    10201 tctatctagt gtaacaaaaa agcagtaatt tttcaactgc tctttcttat ttatttagca
    10261 taatctactg cacgaagctc gcgaatcacg gttaccttga tatttcctgg ataatcgaga
    10321 ttgttttcaa ttttcttacg aactttgtga gccaagattg tgactttgtc gtccttgatt
    10381 tttcctggat tgaccatgat acgaatttca cgtcctgctt gaagggcaaa gctagtttgc
    10441 actccttcaa agccgttagc aatttcttcc aaatcatgga gacgcttgat gtagctttca
    10501 agagactcac tacgagcacc tggacgggct gcgctcaagg catctgctgc agcgacgata
    10561 actgctatca cgctctcagc ttcaacatct ccgtggtgac tagcaatcgt attcaccaca
    10621 actgggggtt ccttgtactt acgggccaat tccataccga tttcaacgtg gctaccttca
    10681 acctcatggt caatggcttt cccgatatcg tgaaggaatc cagcacgacg ggcaagagcc
    10741 gcattttcac caagttcgct cgccatgata ccagccaact tagcaacctc aatcgaatgg
    10801 cgcaaaacat tttgtccata tgaagtacgg aactgcaaac gtcccataat cttcatcaag
    10861 tctggatgaa ggtttggcgc accaatttca taggcagcag cctcaccgta ttcacgaatc
    10921 ttattgtcaa tctcttgacg gtttttctca accaactctt cgatacgagc tggatgtata
    10981 cgaccatctt tgagcaacat ttccatagtc atacgggcaa tctcacgacg aatcggatca
    11041 aatcctgaca aggtcaccac ttctggtgta tcgtcgataa tcacatcgac ccctgtcaaa
    11101 ctttcaaagg tacgaatgtt acgaccttca cgaccaataa tgcgtccctt catagtatcg
    11161 tctggcagat gaactgttga gtttgttgac tccgctacat attcaccagc gatacgttgc
    11221 atagcttgaa ccaagatgtc cttagccatt ttgtcagaac gttccttgac ctcttgctca
    11281 gcttcgcgaa tgcgactggc aatctccctg gtcaagtttt cctctgtctg agccaagata
    11341 atatctcgtg cttctgcctg agacagagca ccaatacgct ctagttctgc ttctttttgt
    11401 ctttcgactt cctctaattg ctcttcacgc gcatcaaggt ttttcgctct atcagaaata
    11461 ctttgttctt tttgttcaag tgtttgttct ttactcgtca aattgtcgtc cttacggtca
    11521 aggctagtag ctctctctgt caaacgactt tcgatttgtt tgagttcttg acgttctgat
    11581 ttgaattcag cgtccacttc ttcacggtat tttctggctt cttctttggc ctccaatagt
    11641 gcttcttttt taagagactt gctttcacgt ttagcttcat taacaagtaa atccgcttca
    11701 cgctcagctt gtccacgtaa attagttgct tcttgttcag catttaaaag catcaactcc
    11761 gcagcttcct gagatgattt catcttagct gagatgctga catatccaat gactaaacca
    11821 atgatgacgg caaaaacagc aatcgcaagc gacatgattt ccatgttttt acctcatttt
    11881 attgttattc cgaatgacat acattctttt acattctacc ataaaaaagt gattttcaca
    11941 aacctaaaat agaatatgtt ttggggaatt tagtctgaat tttaggatta cacttccttg
    12001 gttttttaag gagataagtc agtgtcgcta tcaaaaagtt ccaccgaatt tctacaacta
    12061 tggattttct attgttgtgc caaatagtgt tccactagat tcaaacattt tgctttcaag
    12121 tctttgaaaa ttcactttag gaaattacag cttatcttca agatcaaatt tgtcataaat
    12181 taactttttt tatttagttg tatcaattta tttcttaagt attaatttat cctcatcgaa
    12241 agcttttaaa atatactcat taatcaattt attatcttct tcattttttg aaaaataagt
    12301 tttaatatta ttgggagttc tatgttctag tagacgatgg ataacatcat cacttctatc
    12361 atggaaccag gtccaatcta cttcaggata aagtcctcga atatcttctt caatatcttt
    12421 taaaatctca aaatcagaaa aatatccttt tctacttaag ttgtataaat ctgatacaga
    12481 cttttctctt gggtctggga aagttttaac cccctcaact cttttatcat taattctttt
    12541 aatcaaataa tggtagattt tattttgtat ctgaggaaaa tcatagacat tataactcat
    12601 caaatcaatt actttatggt aaataatatt ttctgattct tcataaactt ttagagtatc
    12661 tagaatgtca tctttaatat ccttttcgaa atacttaaat aagtggcata tcaagtcaga
    12721 atattctatg atatttttta tatcatcatt tttatatttt attcttaaaa tatctgtatt
    12781 aaatttttcg agtactatta ttgcagtttc ctgatcagtt gagcagtatt ctagtaactg
    12841 tgaatagagt ggatacactg aattatataa agaaaaattt ttctccaaaa tttcatttaa
    12901 atgtttattt acaatcccaa ttatcttaga tttcaatgaa tctttatcaa taacatccat
    12961 attatcgagg acaattttaa taattctcct aaattcctct ctccaattat aatacagtgt
    13021 ttgattattt aaaatttcta ttactttttc tatgtcaata tcatcaacaa gaggaagaaa
    13081 aattagcata tttttaagct ctcgaagatt ttcatcttca gtaatttcaa gtctttcttg
    13141 aagataagta attcgattca acaagtagtc tttcgcttcc tcagtaactt ttattttacc
    13201 aaatgaatag tttctaaaat ataaatttac aaccttaaaa tctatattcg gaagaattaa
    13261 ttgaacatca tccaaatcaa gatttttaag ccaagaagat gttctatcga aaatacttga
    13321 gtcaggattt acatatgaat tatcataact gagtaataat atttctaaat atctattaat
    13381 gattgattta taaatcttat aatgttcaac acataaacaa tttaatttta aaaagttata
    13441 aagatttttt actgtaaact ccgcattaaa tagatgatta ttagcagacc atcctcctct
    13501 tctatagctt tcatgctctt cacgaatttc atcaaataat tcattaatag tttctaattt
    13561 tctatataaa aaattgaagt taaggattga atctctaaaa aattctataa tctttttctc
    13621 atctcctgta accgagttaa gaatttgttc tgttaattcg cttaattctc catcataaag
    13681 tggctctgca taactaggtg ttttttcgta tctatcaatt atttgaattt gctgaaaatt
    13741 aaattcacaa actaagaaat taaaatagtc tttctgacga aatgctatat tagctagttc
    13801 tctaaatttt gcttttgcta aagaatattg tttttcttca tacaacttaa aagccttact
    13861 taagaatcga ttccccttta aatccctagg ctcaccaatc tccatatcta gaaagcgatt
    13921 taataaagat tttttagata ccataattcg taattcttca tgaccatcaa tttcaaatct
    13981 taattgatca tttccaaacc agcaatactc atcatcccag tttaaagccc ttttctttaa
    14041 atcagaatat ctagaaaaat ctttcgcatc aataaaacta agtctatcta aaaaagccag
    14101 ttgattccat aaatcatcag cattatttac atcttgactt cggttttctg atagaacctc
    14161 taaaaaatct tttgtcctgc aatacaattt gttctgtttt tctgatgtct cctgacctag
    14221 attctcttca ttagagataa tgaaaattcc ttgcttctta taatactctc gaatgatcat
    14281 agacggttcc tcgggagtat aaaaataagc atttttagca tccaatttaa atgtattttg
    14341 aatcattcta aaaattgaat taaaagtcga atcacttaga gaatacccca caaacaatag
    14401 agtatgattc attatcaatg actggattaa agtagaaatc attgggaagt tcaaatgata
    14461 gtctaaataa tcatcttctt tcaaaacaat atttttctta ctgaagtcac catgcatttt
    14521 aatcaagtat ctttccgaac tcgtataagg gatgtcttta tcctcagcga ctacattgta
    14581 ctttaacaag ccactttcaa attgactctc cagaagtgaa tcatagtttg tcgtaataat
    14641 atgttttggt gcaatttttt ctattaattt atgtaactca tttggtttac tcaatccctt
    14701 cttaaagaaa atttcttcta tcttctttgt gtactgattt ttcccaaaag tatcataata
    14761 atactgagca attctcagtg gactatctgt tctttcttct ggtatgttca attctttttt
    14821 taatgattga atcaattctc cccaagttgg tagattagaa ttagctgata ttcctgcacc
    14881 aacaaacaaa actaaggaat tttctttaat agaattcttt atttgagtta tagataaatt
    14941 ataattttct tccatatttt aactatccta tcattagctt gtattacata aatacaaatt
    15001 attcttataa atcttctttt ttattacata atcttaaaca aaagtttatc atggtttata
    15061 aatataaaaa tttatttgtc ttttatattc aatttatgat ttttaatata accagttctc
    15121 ttcattatac cacaaaataa caagcataaa gcggattcaa agataaagat taaggttcat
    15181 atactaattt tctttattga ctttttgtct tctgtattag ggagtttatc attttccaaa
    15241 aactttatct tcaatttgtt agctaaaatt tctacaataa aaaagcctac ctttcagtag
    15301 acttagtttg tttctattct aatcggcact ctgccaaaat tctgttctgc tatacttgga
    15361 tttcccaatt ggtaaatctg gtctgccttt tgagtcatga catcccaagg ttccttgcca
    15421 attctgctga ctagactgac ctgccctttc agatatttaa gatgttgcct gcctttttcg
    15481 gtaaagccaa ggacatgaat cccttctggc aagtcacttt ctctagcctg caccaagata
    15541 taggtcaaga ggcgtctgac acgcgccttg gtgtaacgtt tggtggtcac taactcgacc
    15601 aattcttcca cagactgggc tgttttaata gcttctttaa tgcgcacagc catttcttga
    15661 ttgacctgat agatggtggt taggtcggga tttgacaaga tttgatagcg gagcaaggga
    15721 aaatagtctt cccagatcac cttactggcc tgctcaaata gggcaacaga aggcataaaa
    15781 cgttctaaga aatcttggtc cttctgatgt tgacggaggg ctgtcgccga ggcaaagtcc
    15841 acatctttat tcacagaatg gtaacctgcc ccctgacgct gaatcggatg cagcttgata
    15901 tttcgtcctg caaccgcctt tgcataggcc agagcaagaa catgattggg ggtattacct
    15961 gaaaaatcaa gaccagcaaa ttccttccac atagcttggg ttttctgggg ataggaaagg
    16021 gaatcaggca gattttccac aaatttctcc atctcagcac ctttctctgt gtataagtca
    16081 gcgattttct gataatctcg aacttcctct gtcccaaaaa ctagactatc aatgcccaag
    16141 cgatccaaga tatccacagc tccttgacca aagaaatcag ctgcctgaac actgactaaa
    16201 aagggcaatt ccactaccaa gtctgcgcca ttttccagcg ccatctgggc ccttgtccac
    16261 ttatccacaa tagcgggctc tccacgctgc atgaaattcc ctgacatggc aacaattttc
    16321 agtccctctg cctgatccag caggtattta tggccattat gaaaaggatt gaactccgcg
    16381 ataatacctg tgatggtcat gctaatctcc tacttctgcg ccacaaaaaa ccaacgggtg
    16441 ctagtttctg ttggctcctt atcctcaaag tctgcataga gtttgaagga cttgaatcca
    16501 gcctgttcca gcaagatatc ataggtcaag atctcatagg tcctctcctc atgtacttca
    16561 tcgtggcgac taaaggaacc gtcagcctcc ttgataaaga aagtcagctc atgcacgatg
    16621 gagtgaggaa cttcgtcctc atatgtatcc caaagcatgg aaaaatcttc cgcattttca
    16681 tggtaggaat agccagggaa tacttcatct gtctggtagg tcgagtgcac gtcaaagatg
    16741 aaaactccct cttcattcag cgcattgtac acgtccttaa agacgtcccc tacttccacc
    16801 tcatcctgca tatagcagat agagtccgaa taacacgtga caaaatcgta tttccctgcc
    16861 ttggacaaat ttagcatatt accttctata aaagcaatct tttgcttggc tgaagttgct
    16921 ctcttctccg caatcttcaa catatccgca ctcaagtcaa gtccagtcac atcaaaacca
    16981 gcctgagaga agcgcactga ttgaattcct gtcccacaag ccagttccaa gagtttcttt
    17041 ttctccttgg tcttaggcaa atgacgcaga gaaaaatttg tccatttgtc gtataaacta
    17101 tcgtccatga ccgcatcata gaccgccgca aaggtttcat aagtcgccat aatcatgata
    17161 ctaagagctc catggtaaac accactagcc ctttaccttt ctatcaattt ttctaaaata
    17221 agcaaagaaa cccagttgac tacaactgag ttcatcttct aagcaagagc ttctgaaata
    17281 tctactgaat tcgcctcatg ccatagcttc tctagattat aatgggcacg catttcttct
    17341 gaaaagatat gcacgacaac agcaccgagg tccagtaaga cccagcctcc agctgcatcg
    17401 ccttcgacat ggctaccttt aaagcccgct tgagctactt tttcacggat attagctgcg
    17461 atagcgtcca actgacggct attcattgag ctagtgatga caaagtagtc cgtcacacta
    17521 gtcaaatctt gtacatcaag tgcgaggata tcctccgcac gtttctcatc agccgctttc
    17581 acgactagtt ctagtaattc tttttcgttc atttaatcct ctttttagaa aatatgtttg
    17641 taatctagga catctgcaaa gtgctcctcc caaatgtcct cataaaattc attaatcgtt
    17701 tctgctggaa tgtcatcccc atcaaaggtt gtgacagcac cttctggaac aataagctga
    17761 tagccatatt caaaggcaac cttgacagag gtatccacac aatattctgt ctgcatacca
    17821 cataaaacta atttttcaat cccctgttta tccaagtatt cttttaagcc agtttctttg
    17881 aaaatactgt tatacttctt ctgaaagacc ttttcagcag gttttcgatt taaaagcgca
    17941 gataactgcc aatcttctga tgtttgagct tcagaattct caatatgttg aacatagata
    18001 atttcaatat tcttgcttct agcctggttt tgtaaataag aaattttttc caatagactt
    18061 tttgtctgga acccagtttc tactaaaaca ttctgaacat caatgattat aaaagccgtc
    18121 ttcatttagt cctctttcaa atagtgcaca aaggcgttat aggtttcaag ggtttgggga
    18181 tagatgggga atccctgatg agctagatac tccacggtac gagctgtttc gtaggccacc
    18241 gccttattga gcgatagact tgcaatctca cgcgccacat ctactccagg aaaggctcga
    18301 ttgtgctcga tatagtctgc gacgtagatg accttatcta ggtctgtcat ttgaccagca
    18361 ccgactgtat ggacttcaat ggctcgcagg atttctgaat catgcaaatc caaatcttcc
    18421 tgaattttgt aaattccgac cataccatgc cagacattat taccccagtt tttgaggtcg
    18481 aaatctagct gataacggtc aatcaagtct agaaattcct gatctgacaa ctttttagca
    18541 tagtcatgaa gaagacctgc tagacttgct ttcccaacat ctacaccaaa gcgctgagct
    18601 aactccatag cggcacgctc cacacctaga caatgggtta gacgtttctc aggtagaagc
    18661 tctgccattt tttccaacaa ggcctcacgg gagcagttga tatagtcttg ataggacatc
    18721 agtagagccc ctccttctcg atgtagtcta gcactggctg aggtaggaga aagttgggtt
    18781 tccgaccttg ggcaatgaag tcccgcacca tgctggacga gatatccatg agcggtacgt
    18841 ccacccagat aactggatag gaagtccctg ccttgtagcg tggacgctga acccccacaa
    18901 actgaaccat gtcaaccagt tcatcaattc ggtaccactt aggcagatag tcaaccatgt
    18961 cggcaccgat gataaagtaa taatccgtat ctggatgttg ctctgtcaag attttcatgg
    19021 tgtcgtaggt gtaggaaata cccttgcgct ccaactcaat ggtttcaatg actaggccgt
    19081 caatcccctc aattgccaac tcaagcatct tgagacgatg gtgttcaggg atggtttcct
    19141 ttttatcaac gtgaggaggt tggtattcag gcatgagaag aacttgatcc agtcccaact
    19201 gttgccgtac ttgatccgca acaatgagat gggcattgtg aacagggtta aaattccccc
    19261 ctaaaatccc aacttgtttg cgttttttct ccttgatttc tggctccaac tctaccttgg
    19321 taaagggagt caatagttcg attgtcatag gctagtcccc tttatttctc tataaaaaca
    19381 gttatttgga gtttcggtct tagatttctt tgactttctt agaaatcttg cgattttctt
    19441 tcttgctaga ttgtttaaac aaaatcaaga tgcgtcctat tttttggact gtatccacac
    19501 cgatttcttc ttccaaaatt tcagctactt cgtggatatt ttcatctgtg ttttgtaaga
    19561 gagtaacctt gattaattca cgcgcatcaa gagcttgacg gacgctggtt ttgatttggt
    19621 cgttgagtcc atttttcccg atttggatga taggtttgag ggtgtgtgcc tggctgttga
    19681 ggaaggcacg ttgttttgat gttaatgaca taattttctt ccttgttttt ggatagttat
    19741 tttaggtggt gagggacggt cggaactaat tttccaaaga tttcatcttt gaaaaatgga
    19801 tttcctgacc tcacaattga gccttggtct caattgtgcc ccttgccaat ctacagattg
    19861 gcaatcacac cacggcaata actatcgcta tatgagctca ctttgttcgc tcagcgattt
    19921 tgttttaaat aattgctttt cgtgtgacga cggcgacgcc ttctggtgcc cagacggcga
    19981 cttttgctat gcctgttaca cgaatccagc ctaggcctga gatgactagg tctgtcttat
    20041 ctttaatggt aaagacatgc tggactagcc ttgggaaatc ttctttttcc ttgctatttg
    20101 gtggtgtcag aagagttccc aggtgcttat cgtagaaagc actagctcct tcaagcttgc
    20161 tacgatggag tttgagttca ttatcaaaga aagcagtaaa tccttgcttt tctcctgcta
    20221 taaagtcaaa gcgtcccaaa ccacctaaaa atagggtttg ctcaggatta agctgatagg
    20281 tcttaggctt gatttccttt ttaggactga catacttgag gtttttggcc gtcaagtagt
    20341 gagccatctg gtggcggtgg ataattcccg gcgtatcgta aatataagat ccgtcgtcaa
    20401 gcggaatctc tattttgtcc aaggttgtac ctgggaagcg tgaagtagtg atgacattct
    20461 gatcacccgt gatttcttgg ataatagcat tgattagagt tgattttcca acgttggtca
    20521 caccgaccac atagacatcg cggcccttac ggtagtgttc aatcttgtca atgacttcct
    20581 taatggcatg tttattttgt gctgaagtta ggaccacatc gactggacga agaccttctt
    20641 catgggcacg tttcatgagc cactggctaa tcttaccaga cttaactgac ttaggaagga
    20701 tatctttttt atttcctacc aagaggacat cattgcccga gacgaaacgt ggtaaacctg
    20761 ggatgacaga tccattaaaa tcaaagatat caatgacatt gaccactaag gcatcactgt
    20821 ctcccacctc gtgcaagagc ttgaggaaat catcgttcgt caactggaca tctgtgattt
    20881 cattgtagtg gcggagacgg aaacagcgtt ggcaatagac ttcgccagtc tccaaacctt
    20941 tttcaagtgc cgactggggg gtaaaaccaa gaccagcttt atctgtcgtc tgaatggttg
    21001 ctccacaacc aatacagaga atttcttcca tagttaaatt ccttttttat atgtaatcgg
    21061 tccgtacttt tcagtgattt ttctcataac acgacgctca cgagttcggt taatctgcgt
    21121 tttgattgag tcatgttgga ccaagggttt gactaaaatt gaccgaatcc ctgcacggtg
    21181 ggctgctcgt atatctgtca tgagctggtc gccaaccatg accacttcct ttttgtcata
    21241 gtggaattcc ttcatggcac ggtcaatacc aaatgtgaag ggcttcaagg cccagtaaac
    21301 gtaatcaatc ccaaatttct caactgctcg ttgaacgcgt tttttggtgt tatttgacac
    21361 tacgataatg ccaacacccg cgtcccgaag gtcatgtagc cattgcttca tctctggcgt
    21421 tccatcaggg ttgttccaag caatgagggt attatccaaa tcgaccaaaa cagccttgat
    21481 tccctgcgcc tgcaggcttg ggactgtcag atcatagact gcttccacag caaaatctgg
    21541 tatataattt tcaatcgcca ttctggctcc ttttcttaac tttttttcgc aattttcctt
    21601 agtaacaagg ataaaacaat ccacaaacct gcactagcca aactgatata gagccaagca
    21661 tggggctcat ctgttaaagg taagggaaca ttcattccga aaaagcctgt cacgactgcc
    21721 aaaacagcta gcaagactga aatgatagtc aaggttgtca aattgtcatt cagattattg
    21781 tttagaatat tgttgtaaga ggctgaaagc tgctgtaaaa tctgagagat taggtctgtc
    21841 atggatacca gctgatgagc ctcaatcatg gcatcatcaa actgttctct ctcaatctca
    21901 tcaaaactac gatacaaggc atgaccttga atatgctcta acaaaatccg attttgtttg
    21961 gcagctgccg tcagataaac cataccagtc tccaaatcag acagggcaaa gaggtttttc
    22021 ttggtagttc gctggcgcaa gaggtcattg acctcatccc tactcttgtc catctgctca
    22081 atgacaggat agtaggcatt gctgatgatt tccagactgg caaagagaaa cttataaatc
    22141 gaaagcgtgt catggctctc cagataacga gtcatctgtt caatgacata ggcgttcttg
    22201 gtattactaa tggtaatcag gcgacgatac tcgacaataa aggtcatggg aaaagtctca
    22261 tagtaggcct tgtccttttt tacgtctagg acattataga taaaggtaac cgtcccactt
    22321 tcacggtggt agtccatgtg ggcgcgctcg tttctatcca gtgcgtattc aatggtttcc
    22381 ttgtccaaac cgtaaatttc agaaaggtct tctagtttat tcaactttcc taggtctagg
    22441 tctatccagg tacaaccatt gcccaactgc ttttctaaaa ccatcttttc tccttattaa
    22501 actccctcta ttgtaccaca aattacttaa aataacaggt ctagtctgtg cgtgagaaat
    22561 tgctaacaac tgtgatattt cggttaggga caaagtgaag ggcttgctcc tcgctacgaa
    22621 gctgtgtcgt acgaattccc acactgacaa ccttacccga tacagtaatc ggtccatttg
    22681 tcagaacgac ctcatctccc acatccagtt gacgttcaaa gaggatgaaa aagccattga
    22741 tgacatcaga cagaaagcct tgggctccca taccaatcgc taccccagca ataccagctc
    22801 cagccagcaa actagaaact ggcaaaccta aaatcgacaa aatgcagtag agtaaaaaga
    22861 aatatagcgt ataattaaac acattttcta gtaaacgtga gatggttttt tggcgtccaa
    22921 catcatgacg agacattttt agagaaggtt tgacaattct ctgcaccatg gtatgaagca
    22981 tttttttagc aatataaaat acaattaaaa gcagtaaaag agaaatgacc ttggttagaa
    23041 tattctcgat aatggttgtc acatctagct tttcaatata agcctgaata aatttttgca
    23101 tataaaactc ctttatttca ttataccata ttttcatcag tctcattctc cataaatatt
    23161 caaaaaatag acagaaaatt cttgattttg tctatcattt atactataat cataatcact
    23221 acacaaaaag gagattatta tgaaaagaat cattcatgct tggaataagg caagccttgt
    23281 caagcgtatc ttgattggta tgctttgtgg ggaatcctag gactgaccct tcctaatctc
    23341 tcagggattg ggctactcga ggatttattc gttggaggtc taaaagctgt tgctcctatc
    23401 ctagtctttg ctctcgttgc caatgccctt tcccaacatc aaaagggaca agatagcaat
    23461 atgaaaactg ttgttttctt gtatatccta tgatagggac tttcgccgct gctcttgtag
    23521 ctgtactagc aaatttcatc gtccctattg aaattacccc aaatagtgcc aatactgaaa
    23581 ttgcaccacc agatgggatt gggcaggttc tcagcaacct cttgctcaaa ctggttgaca
    23641 acccagtcaa cgccctgctt actgctaact atattagaat cttatcttgg gcagtcattt
    23701 ttggaatcgc tatgagagaa gccagtaaaa atagtcaaga attgctaaaa actatcgctg
    23761 acgtgacttc taaaattgtc gaatggatca tcaatctggc tccatttgga atccttggtc
    23821 ttgtttttaa aaccatttct gacaagggag tcggaagcct tgccaactac ggtattttat
    23881 tggttctatt agtaacgact atgctttttg ttgcccctgt ggtcaaccct ttgattgcct
    23941 tcttctttat gagacgcaat ccttaccctc tagtttggaa ctgcctccgt gtcagcggtg
    24001 tgacagcctt tttcactcgt agttctgcga ctaacattcc tgtcaacatg aaactctgcc
    24061 atgaccttgg actcaaccca gatacctatt ctgtttctat cccactcggt tctactatca
    24121 atatggctgg agtagcgatt accattaacc ttttgaccct tgctgcagtt aacactcttg
    24181 gaattcctgt tgactttgcc acagcctttg tcctcagtgt ggtagcagct atctcagcct
    24241 gtggtgcttc aggtattgcc ggaggttccc tccttcttat cccagttgct tgtagccttt
    24301 tcggtatttc taacgatatt gccatacaag ttgttggggt tggttttgtg attggtgtca
    24361 tccaagactc atgtgaaaca gcccttaact cttctacaga tgtcctcttt accgccgttg
    24421 ccgaatacgc agcaacccgt aaaaaataac tcatcaaggc aagcctgctc atgtcttgtc
    24481 ttttacgctt ttattctaac ttattaggaa attcttatgt ctattagcca acgtacgacc
    24541 aagctcatct tagctacctg tcttgcctgc ctgcttgctt attttctcaa tctttcgtca
    24601 gcagtttcgg ctggaattat cgctctcttg agcctatctg atacgcgtag aagtacttta
    24661 aaactggctc gcaatcgtct tttttctatg cttctagctc tggctatcgg tgttctagct
    24721 tttcacttga gcggatttca tatctggagt ctcggcctct atctggcctt ctacgttcct
    24781 ttagcctaca agatgggctg ggaaattggc atcacaccaa gcactgtttt ggttagccat
    24841 ctcttggttc aagagtcaac ctctccagac cttctagtca atgaattcct tctctttgct
    24901 attggtacag gatttgcctt gcttgttaat ctctatatgc cttcacgaga agaggaaatc
    24961 cagcactacc acacgctggt ggaagaaaag ttaaaagata tcctccagcg cttcaaatac
    25021 tatttatcca gaggagacgg acgcaaccga gcacagctgg tagcagaatt agacacgctt
    25081 ttgaaagaag ccctcagact ggtctatttg gatcactctg accacctctt tcaccagacc
    25141 gactaccata tccactactt tgagatgaga caacgacaaa gtcgtatcct gagaaacatg
    25201 gcccaacaga ttaacacttg tcaccttgcc gccagtgaaa gcctgatctt agcgcaactc
    25261 ttttcaaaaa ttgcaggtca actgagccag accaatcctg cttctgattt gctagatgaa
    25321 attgaacgtt atctggaagt cttccggaac cgcagtctgc ccaagacaag agaagaattt
    25381 gaaacccgcg ccacccttct tcaactccta cgtgaagcca aaaccttcat ccaagtaaaa
    25441 gttgattttt accaaaaata tagacagtaa tactcttcaa actacgtcag cttcaccttg
    25501 ctgtatatat gtt
//
LOCUS       DBERMM010000026        24209 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.026, whole genome shotgun sequence.
ACCESSION   DBERMM010000026 DBERMM010000000
VERSION     DBERMM010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 24209)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24209)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24209
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.026"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(20..244)
                     /locus_tag="ACL8AS_001353"
     CDS             complement(20..244)
                     /locus_tag="ACL8AS_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory secretory protein Asp5"
                     /protein_id="HGS1229201.1"
                     /translation="MIDILIVLAIILSLALIVLVTIQPRQNQLFSMDATSNIGKPSYW
                     QSNTLVKVLTLLVSLALFVLLLTFMVITYK"
     gene            complement(249..428)
                     /gene="asp4"
                     /locus_tag="ACL8AS_001354"
     CDS             complement(249..428)
                     /gene="asp4"
                     /locus_tag="ACL8AS_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory secretory system protein Asp4"
                     /protein_id="HGS1229202.1"
                     /translation="MSEEDLFYKDVEGRMEELKQKPIKKEKETRGEKISKTFSLLLGL
                     MILIGLLFTLLGILR"
     gene            complement(430..1767)
                     /gene="gtfB"
                     /locus_tag="ACL8AS_001355"
     CDS             complement(430..1767)
                     /gene="gtfB"
                     /locus_tag="ACL8AS_001355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0031647 - regulation of protein stability
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system glycosylation chaperone
                     GtfB"
                     /protein_id="HGS1229203.1"
                     /translation="MIELYDSYSQESRDLHESLVATGLSQLGVVIDADGFLPDGLLSP
                     FTYYLGYEDGKPLYFNQVPVSDFWEILGDNQSACIEDVTQERAVIHYADGMQVRLVKQ
                     VDWKDLEGRVRQVDHYNRFGACFAKTTYDVLGQAIMTSYRDVDQKEVILENHVTGDIL
                     LTLPGQSMRYFANKVEFITFFLQDLEIDTSQLIFNTLATPFLVSFHHPDKSGSDVLVW
                     QESLYDAIPGNMQLILESDNVRTKKIIIPNKATYERALELTDEKYHDQFVHLGYHYQF
                     KCDNFLRRDALILTNSDQIEQVEAIAGALPDVTFRIAAVTEMSSKLLDMLRYPNVVLY
                     QNASPQKIQELYQLSDIYLDINHSNELLQAVRQAFEHNLLILGFNQTVHNRLYIAPDH
                     LFESSEVAALVETIKLALSDVDQMRQALGKQGQHANYVDLVRYQETMQTVLGG"
     gene            complement(1760..3271)
                     /gene="gtfA"
                     /locus_tag="ACL8AS_001356"
     CDS             complement(1760..3271)
                     /gene="gtfA"
                     /locus_tag="ACL8AS_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system glycosyltransferase GtfA"
                     /protein_id="HGS1229204.1"
                     /translation="MTIYNINLGIGWASSGVEYAQAYRAGVFRKLNLSSKFIFTDMIL
                     ADNIQHLTANIGFDDNQVIWLYNHFTDIKIAPTSVTVDDVLAYFGGEESHREKNGKVL
                     RVFFFDQDKFVTCYLVDENKDLVQHAEYVFKGNLIRKDYFSYTRYCSEYFAPKDNVAV
                     LYQRTFYNEDGTPVYDILMNQGKEEVYHFKDKIFYGKQAFVRAFMKSLNLNKSDLVIL
                     DRETGIGQVVFEEAQTAHLAVVVHAEHYSENATNEDYILWNNYYDYQFTNADKVDFFI
                     VSTDRQNEVLQEQFAKYTQHQPKIVTIPVGSIDSLTDSSQGRKPFSLITASRLAKEKH
                     IDWLVKAVIEAHKELPELTFDIYGSGGEDSLLREIIANHQAEDYIQLKGHAELSQIYS
                     QYEVYLTASTSEGFGLTLMEAIGSGLPLIGFDVPYGNQTFIEDGQNGYLIPSSSDHVE
                     DQIKQAYAAKICQLYQENRLEAMRAYSYQIAEGFLTKEILEKWKKTVEEVLHD"
     gene            complement(3283..5655)
                     /gene="secA2"
                     /locus_tag="ACL8AS_001357"
     CDS             complement(3283..5655)
                     /gene="secA2"
                     /locus_tag="ACL8AS_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA];
                     GO_process: GO:0015031 - protein transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system translocase SecA2"
                     /protein_id="HGS1229205.1"
                     /translation="MFRRLGQDFQLRKVKKILKQINALKGKMSSLSDQELVAKTVEFR
                     QRLSEGESLDDILVEAFAVVREADKRILGMFPYDVQVMGAIVMHYGNVAEMNTGEGKT
                     LTATMPVYLNAFSGEGVMVVTPNEYLSKRDAEEMGQVYRFLGLTIGVPFTEDPKKEMK
                     AEEKKLIYASDIIYTTNSNLGFDYLNDNLASNEEGKFLRPFNYVIIDEIDDILLDSAQ
                     TPLIIAGSPRVQSNYYAIIDTLVTTLVEGEDYIFKEEKEEVWLTTKGAKSAEDFLGID
                     NLYKEEHASFARHLVYAIRAHKLFTKDKDYIIRGNEMVLVDKGTGRLMEMTKLQGGLH
                     QAIEAKEHVKLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRI
                     PTNRPRQRIDYPDNLYITLPEKVYASLEYIKQYHAKGNPLLVFVGSVEMSQLYSSLLF
                     REGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRGTDIKLGKGVAELGGLIVI
                     GTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDM
                     TQPEVLKGRKYRKLVEKAQHASDSAGRSARRQTLEYAESMNIQRDMIYKERNRLIDGS
                     RDLEDVVVDIIERYTEEVAADHYASRELLFHFIVTNISFHVKEVPDYIDVTDKTAVRS
                     FMKQVIDKELSEKKELLNQHDLYEQFLRLSLLKAIDDNWVEQVDYLQQLSMAIGGQSA
                     SQKNPIVEYYQEAYAGFEAMKEQIRADMVRNLLMGLVEVTPKGEIVTHFP"
     gene            complement(5648..6088)
                     /gene="asp3"
                     /locus_tag="ACL8AS_001358"
     CDS             complement(5648..6088)
                     /gene="asp3"
                     /locus_tag="ACL8AS_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein Asp3"
                     /protein_id="HGS1229206.1"
                     /translation="MIITQRQSIHWGEVGGTYMYGTTVSYYPDKSVRLYNPLLPSGEI
                     LKTWFSSVNYQAARTQPQLPLLKRKQEYQLSLVFDCQPENGVYTKITFFDRYGDILEK
                     KVEKAKDFIFTYPEDSYTYQVSLLSAGFESLTFYHFSIKEIRSV"
     gene            complement(6085..7620)
                     /gene="asp2"
                     /locus_tag="ACL8AS_001359"
     CDS             complement(6085..7620)
                     /gene="asp2"
                     /locus_tag="ACL8AS_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein Asp2"
                     /protein_id="HGS1229207.1"
                     /translation="MSKELNILQIGLANWENHYDIPENMSWYYFYPNSSKALREIIEK
                     EDINRFHAVLIEDGQYSRDLFSYVKYFEPYTLFYNQNLQINDREVVDFLKKRCAQAID
                     FLSPQQLINDLSKSLFGGGYGDKLFPPTIQVNPNFTGAISYQGLDYVSLEGEFGQDFA
                     QLAYWAYNIMVQKTLPIELWLEYEKEGNCDFRLVIRKMWSGSVDDFFEEVIVSEKDLE
                     QALFMDSRDGDYFLSISVEARGRGTIKLGNLHQRWSRKQFGKFVLGGNILHDSKRDEI
                     NYFFHPGDFKPPLTVYFAGYRPAEGFEGYFMMKTLGCPFILFSDPRLEGGAFYLGTDE
                     LEGKVKDTITHYLDYLGFDHKDLILSGLSMGTFPALYYGASFEPHAIIVGKPLANLGT
                     IASRGRLDAPGVSNLAFDCLIHHTGGTSSQDMTELDQRFWKIFKQANFSKTTFGLSYM
                     KDEEMDPQAYEQLVSYLCNTGAKILSKGTAGRHNDDTDTNISWFLHFYRMVLETGFGR
                     EKR"
     gene            complement(7604..9184)
                     /gene="asp1"
                     /locus_tag="ACL8AS_001360"
     CDS             complement(7604..9184)
                     /gene="asp1"
                     /locus_tag="ACL8AS_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein Asp1"
                     /protein_id="HGS1229208.1"
                     /translation="MYYFIPAWYGSERTWHADITPWYFSHFRLEFDDTFHQIRLFQEQ
                     DIDSRLLVLAYQPHLRYFLYRHGVLEMDTYSVFDVMQDFHNLHTQVLSIRDIEWDDDC
                     EFIYSPFTIIVQKNGKKFAKVEHGVEGFISDIQYFEPNGQIHMHHIVDDRGFVSSIIF
                     FEDGQAAYQEYLNLKGEWQFRERLKEGGQVEVNPILGYRFKMLTYQNMGDLVAEFFEN
                     YLQTYVKDQDIFMLPSHSHHDQLVLDRLPSTNPKLLSLFIGRNPQDTFRDLDVTFEKS
                     DLILVDREDSLRLLQELYPERMHQCYHLSSFDTRLRLGRSQTKKESIIYFQLDFEQGI
                     DNQALLQVLSFVAENKDTEVIFGAFAASQEQMNEVEGIVESFIQENIQSENLGKAIDY
                     GDAENPLEENQHQDLRLQFVNLNDELDLIKTLEFVRLIVDLNRHPHLYTQIAGISAGI
                     PQINLVETVYVEHLKNGYLLADVTEFSKAAHYYTDRLKEWNESLIYSIDKIKEHTGQQ
                     FLGKLEKWIEEVKNVKGT"
     gene            complement(9194..10411)
                     /gene="secY2"
                     /locus_tag="ACL8AS_001361"
     CDS             complement(9194..10411)
                     /gene="secY2"
                     /locus_tag="ACL8AS_001361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein translocase subunit
                     SecY2"
                     /protein_id="HGS1229209.1"
                     /translation="MTKIYSSIAVKKGLFTLFLLFIYVLGSRIILPFVDLNTKDFLGG
                     STAYLAFSAALTGGNLRSLSIFSVGLSPWMSAMILWQMFSFSKRLGLTSTSIEIQDRR
                     KMYLTLLIAVIQSLAVSLRLPVQSSYSAILVVLMNTILLIAGTFFLVWLSDLNASMGI
                     GGSIVILLSSMVLNILQDVLETFQTVHIPTGIIVLLALLTLVFSYLLALMYRARYLVP
                     VNKIGLHNRFKRYSYLEIMLNPAGGMPYMYVMSFLSVPAYLFILLGFIFPNHSGLAAL
                     SKEFMVGKPLWVYVYISVLFLFSIIFAFVTMNGEEIADRMKKSGEYIYGIYPGADTSR
                     FINRLVLRFSVIGGLFNVIMAGGPMLFVLFDEKLLRLAMIPGLFMMFGGMIFTIRDEV
                     KALRLNETYRPLI"
     gene            complement(10468..11373)
                     /locus_tag="ACL8AS_001362"
     CDS             complement(10468..11373)
                     /locus_tag="ACL8AS_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001292324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1229210.1"
                     /translation="MSELISVVVPIYNTGKYLVECVEHILKQTYQNIEIILVDDGSTD
                     NSGEICDAFMMQDNRVRVLHQENKGGAAQAKNMGISVAKGEYITIVDSDDIVKENMIE
                     TLYQQVQEKDADVVIGNYYNYDESDGNFYFYVTGQDFCVEELAIQEIMNRQAGDWKFN
                     SSAFILPTFKLIKKELFNEVHFSNGRRFDDEATMHRFYLLASKIVFINDNLYLYRRRS
                     GSIMRTEFDLSWARDIVEVFSKKISDCVLAGLDISVLRIRFVNLLKDYKQTLEYHQLT
                     DTEEYKDICFRLKLFFDAEQRNGKS"
     gene            complement(11373..12569)
                     /locus_tag="ACL8AS_001363"
     CDS             complement(11373..12569)
                     /locus_tag="ACL8AS_001363"
                     /EC_number="2.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 8 protein"
                     /protein_id="HGS1229211.1"
                     /translation="MRKSIVLAADNAYLIPLETTIKSVLYHNRDVDFYILNSDIAPEW
                     FKLLGRKMEVVNSTIRSVHIDKELFESYKTGPHINYASYFRFFAIEVVESDRVLYLDS
                     DIIVTGELATLFEIDLKGYSIGAVDDVYAYEGRKSGFNSGVLLMDVAKWKEHSIVNSL
                     LELAAEQNQVVHLGDQSILNIYFEDNWLALDKTYNYMVGVDIYHLAQECERLDDNPPT
                     IVHYASHDKPWNTYSISRLRELWWVYRDLDWSEIAFQRSDLNYFERSNQSKKQVMLVT
                     WSADIKHLEYLVQRLPDWHFHLAAPCDCSEELTSLSQYTNVTVYQNVLHSRIDWLLDD
                     SIVYLDINTGGEVFNVVTRAQESGKKIFAFDITRKSMDDGLYDGIFSVERPDDLVDRM
                     KNIEIE"
     gene            complement(12578..13798)
                     /locus_tag="ACL8AS_001364"
     CDS             complement(12578..13798)
                     /locus_tag="ACL8AS_001364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HGS1229212.1"
                     /translation="MRNTKRAVVFAGDYAYIRQIETAMKSLCRHNSHLKIYLLNQDIP
                     QEWFSQIRIYLQEMGGDLIDCKLIGSQFQMNWSNKLPHINHMTFARYFIPDFVTEDKV
                     LYLDSDLIVTGDLTDLFELDLGENYLAAARSCFGAGVGFNAGVLLINNKKWGSETIRQ
                     KLIDLTEKEHENVEEGDQSILNMLFKDQYSSLEDQYNFQIGYDYGAAAFKHQFIFDIP
                     LEPLPLILHYISQDKPWNQFSVGRLREVWWEYSLMDWSVILNEWFSKSVKYPSKSQIF
                     KLQCVNLTNSWCVEKIDYLAEQLPEVHFHIVAYTNMANELLALTRFPNVTVYPNSLPM
                     LLEQIVIASDLYLDLNHDRKLEDAYEFVLKYKKPMIAFDNTCSENLSEISYEGIYPSS
                     IPKKMVAAIRSYMR"
     gene            complement(13829..16273)
                     /locus_tag="ACL8AS_001365"
     CDS             complement(13829..16273)
                     /locus_tag="ACL8AS_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_1767 family glycosyltransferase"
                     /protein_id="HGS1229213.1"
                     /translation="MNKTIVLAGDRNYTRQLETTIKSILYHNRDVKIYILNQDIMPDW
                     FRKPRKIARMLGSEIIDVKLPEQTVFQDWEKQDHISSITYARYFIADYIQEDKVLYLD
                     SDLIVNTSLEKLFSICLEEKSLAAVKDTDGITFNTGVLLINNKKWRQEKLKERLIEQS
                     IVTMKEVEEGRFEHFNGDQTIFNQVLQDDWLELDKEFNLQVGHDVTAFYNKWENYFNE
                     LVPPSIIHFVSYRKPWTTLIANRYRDLWWEFHDLEWTKILQHHIGEFELTSSLDKEFS
                     CLTLTNSQDLEGIEELVTALPDVVFHIAAWTDMGDKLKKLAVYNNVRLHPQIVPPVLD
                     KLERSVDLYLDINYSHVVGTILEDMKILEKPILSFDTTEHGNTGQLVFKKDEVSVMVQ
                     AIKDYRRDGRFLSCYEGSDFHCLTFTNSQELQKIDYLVKNFPMVTFHIAAWTVMGPML
                     QKLAKKYKNVKLYPEVKSDQFEELKSQMDVYLDINLHNSTSEVVKEISSLNKPMLAFY
                     TSQNGNHGQHLYSSEHPERLLQAFHALIKGETLGEPEKPIKVIGIDQTLDYVIKNKSS
                     LVRFGDGEVNLMWGLPIPYQNHDLELANQLKHIVGLESDEKLVVCLPDAFDDRFVFTW
                     WATPFWKEHMNVYMDFYKELCKGSWYGSTFISRPYIDYEDKSKAKGQFENLKSIWENR
                     DILIVEGITSRSGVGNDLFDKIKSVKRIICPSHNAYSVVDNIQEEIMKHAEGRLILCM
                     LGPTAKVLSYNLCQMGYQVLDVGHIDSEYEWMKMGAKTKVKFSHKHTAEHNFDQDIEF
                     IDDETYNSQIVARILN"
     gene            complement(16283..17293)
                     /locus_tag="ACL8AS_001366"
     CDS             complement(16283..17293)
                     /locus_tag="ACL8AS_001366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HGS1229214.1"
                     /translation="MKLHLTNLYGMAGDSTVILAQNAVQKIASQLGFREVGIYFYNIS
                     SDSPSEMNKRLDGIMASISIGDILVFQSPTWNGFEFDRLLFDKLKDMQVKIICFIHDV
                     VPLMFDSNYYLMKDYLYMYNLSDILIVPSEQMKERLIEEGLTTKKILIQGMWDHPHDL
                     SLYTPAFKKELFFAGSLERFPDLQNWSQDTPLRVFSNKGEASSSARNLSIEGWKKDEE
                     LLLELSKGGFGLVWGTHQNEGESNQYYTLNISHKVSTYLTAGIPVIVPSSLSTAKFIV
                     YQGLGFVANSLEEVHEIVDKMNLQEYQEMTNRIKTFSYLLKEGYFTKKLLVDAIYHLG
                     ID"
     gene            complement(17333..18538)
                     /locus_tag="ACL8AS_001367"
     CDS             complement(17333..18538)
                     /locus_tag="ACL8AS_001367"
                     /EC_number="2.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000709340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 8 protein"
                     /protein_id="HGS1229215.1"
                     /translation="MKKAIVLGADNHYMDKVETTIKSICSKNKEVKFYVFNSDLPIEW
                     FQLMDKRLSVLGSEIVNVKVTESLINQFHLPTPHLSSATYLRYFIPTIVFEKRVLYLD
                     SDIIVTADLTSLFEFPLDGCPLAAVPDIPNTSEGFNSGVLLIDTDRWREDDIQNQLLN
                     LTIKHHEHVYGDQEILNMLFKDRWKKLSLSYNLQVGYDTYRHSLGDNEWYHLFEGIPN
                     IIHYTTQNKPWSHYRFNRFRDIWWFYYGLNWNDILLDNQILQENFEKLIKPITCHASI
                     FTNTGDIEGLPYLLEQLPNVQFHIAAPTYFSPNIVELQRYSNLYIYPCVDPKMKETLI
                     NQTNFYLDINYGPALDDALQEIVRQGNPIYSFESTSHFSNGENQVFAVDNVDEMVKSI
                     QNKLSESHR"
     gene            complement(18547..19422)
                     /locus_tag="ACL8AS_001368"
     CDS             complement(18547..19422)
                     /locus_tag="ACL8AS_001368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000752824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1229216.1"
                     /translation="MADELISIIVPIYNVEKYLRQCLDSIQNQTYQNFECLLINDGSP
                     DHSSKICEEFVEKDSRFKYFEKANGGLSSARNLGIECSGGAYIAFVDSDDWLESDYLE
                     VLYSKIVEYDTDFVIGSYKKFSMSDNCYYMHVWEQDYYEKIWTSQELITVLPNIENYD
                     SSYTVSWGKLFKRFLFDEVLFNEQRRFGEDFECSFKLYLTMTSCLYIHRALYNYRVHS
                     ESMVGKVRTERQLMDDVEIRLGRIPFLIGRGIDSTPYIAEIKRLIQWRLDTKSDVEEG
                     ESNALCMYREILRNL"
     gene            complement(19427..20635)
                     /locus_tag="ACL8AS_001369"
     CDS             complement(19427..20635)
                     /locus_tag="ACL8AS_001369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HGS1229217.1"
                     /translation="MDTKKAIVLGADNNYRDKLETTIKSICYHNRDLKFYIFNEDIPK
                     EWFYLMEKRLEKLNCEILNIEIDAEKVKYFSTPDEHIKYMTYFRYFIAEFVKEDRAVY
                     LDCDMVIHGNINPLFQKDFEGNYIIAVPDGWYKNIFNAGMMMVNVHKWKTDNICQNLL
                     ELTAEKHQEIYGDQGVLNLLFENKWKKVSPHYNFMVGLDTLGYWAQKPEWFLNSWDEN
                     YKPAIIHFEGKDKPWNDSLKTRYRELWWFYNGLDWQTILSQVDNKPTTFSEIATVSLF
                     HTAIFTDTHELEHIEYLVEKLPNVHFHIFAHSYFGPRVQALNHFLNVSLYPNYTPYQS
                     QEVLSKLDFYLDINHNHEIDNIISKVHNLSKPIFAFENTSHDTNNRSQILPSTEPKEM
                     VEAIRQFIGE"
     gene            complement(20645..21523)
                     /locus_tag="ACL8AS_001370"
     CDS             complement(20645..21523)
                     /locus_tag="ACL8AS_001370"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0120225 - coenzyme A binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase"
                     /protein_id="HGS1229218.1"
                     /translation="MKKNHLVGDALILTVSDQIEELDYLLESLPNICFHIAAPVQFSE
                     KIRSLETNYNVRLRTITNEEQLNFLVDTCDFLLDINHFQEVDAIVSKFVQAGKSVFAF
                     DNTVHGNQGQEVFLSSTPDKLVSRVRDYLNEVRVGTNHQEKIIQDGTWNVFQINNKAD
                     LIVGANVICRNFENFHVSSGKLILNDGVFINNSCSFNCMERIEIGAGTMMGEGVRFYD
                     HDHIYTAEKIEKWQWTTAPIRVGRDCWIGSNVTILKGVTIGDNTIIGAGCLIRNDIPS
                     NSVVYNNGNLVVKERR"
     gene            complement(21520..23604)
                     /locus_tag="ACL8AS_001371"
                     /pseudo
     CDS             complement(21520..23604)
                     /locus_tag="ACL8AS_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000341103.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
     gene            complement(23665..>24209)
                     /locus_tag="ACL8AS_001372"
     CDS             complement(23665..>24209)
                     /locus_tag="ACL8AS_001372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HGS1229219.1"
                     /translation="TSASASSSTSASESASTSASVSASTSASASASTSASESASTSAS
                     ASASTSASVSASTSASVSASTSASESVSTSASASASISASASASTSASASASTSASTS
                     ASESASTSASASASTSVSNSANHSNSQVGNTSGSTGKSQKELPNTGTESSTGSVLLGV
                     LAAVTGIGLVAKRRKRDEEE"
BASE COUNT         7776 a         5080 c         3704 g         7649 t
ORIGIN      
        1 gaatatctga agttttcttt tatttataag taatcaccat aaaggttaat agtagaacaa
       61 ataaagccaa actcaccaat aaagtgagca ccttgaccaa ggtgttgctc tgccagtagc
      121 ttggtttacc aatattacta gtggcatcca tggaaaatag ttgattttga cggggttgta
      181 tagttaccaa tacaatcaaa gcaagagata ggataatagc taaaacaatt agtatgtcaa
      241 tcatagatct acctcaaaat tcccagcaaa gtaaagagca aaccaatcag aatcattaag
      301 cccagtaaaa gtgaaaaagt cttactaatc ttttcccctc gggtttcttt ttccttcttg
      361 atgggttttt gtttcaactc ttccatgcgg ccttcaacgt ctttgtaaaa taaatcttcc
      421 tctgacatgt tagcctccta aaacagtttg catggtttcc tgatatctca ccaagtcaac
      481 ataatttgca tgttggcctt gtttgccaag tgcctgacgc atttgatcaa catctgaaag
      541 ggccaattta atggtctcaa ccaaagcagc aacttcacta ctttcaaata gatggtctgg
      601 agcgatataa agtctattgt gcaccgtctg attaaagcca agaatcaaga gattgtgctc
      661 aaaggcctga cgcactgcct gtagcaactc attactgtgg tttatatcca agtaaatatc
      721 cgacagttga tacagctcct gaatcttctg tggactagcg ttctgataaa ggaccacatt
      781 aggataacga agcatatcta agagcttaga agacatctct gtcaccgctg caatacggaa
      841 agtgacatca ggcaaggctc ctgcgattgc ttctacttgc tcaatctgat ctgaattggt
      901 caagattaag gcatctcgtc ttaggaaatt atcacatttg aactggtaat gataacccaa
      961 gtgcacaaac tgatcatggt atttctcgtc agttaactct aaagcgcgct cataagtcgc
     1021 cttatttgga atgatgatct tcttagtacg cacattatca ctttccaaaa tcaactgcat
     1081 attacctgga atggcatcat agagagattc ctgccatacc aagacatccg agccagattt
     1141 atctggatga tggaaggaaa ccaagaaagg agtcgctaga gtattaaaga taagctgact
     1201 ggtgtctatt tccaaatctt gcaaaaagaa ggtgataaat tcaactttat ttgcaaagta
     1261 acgcatggac tgacctggca aagtcaataa gatatcaccc gtcacatggt tttccaaaat
     1321 aacttccttt tgatctacgt cccgatagga agtcataata gcttgcccca aaacatcata
     1381 agtggtttta gcaaagcaag caccaaagcg attatagtgg tcaacctgac gtactcgacc
     1441 ttctaggtct ttccagtcta cctgtttaac caagcgaacc tgcattccat cagcataatg
     1501 aatgacagcc ctctcctgcg tcacatcttc aatacaagca gactgattat ctcctaaaat
     1561 ttcccaaaaa tctgaaacgg gaacttggtt aaaatagaga ggttttccat cctcgtaacc
     1621 tagataatag gtaaaaggag aaagcagacc atcaggcaga aaaccatctg catcgatgac
     1681 cactccaagt tgagaaagac cagtagcgac tagactttca tgtaaatctc gactttcttg
     1741 actgtaacta tcataaagtt caatcatgga gcacctcctc tactgttttc ttccactttt
     1801 ctaaaatttc tttggtcaag aagccttctg caatttgata agaataggca cgcatagctt
     1861 ccaaacgatt ttcttgatac aattgacaaa tcttagcggc ataagcttgc ttgatttggt
     1921 cttctacatg gtcagatgaa cttggaatca aataaccatt ttgcccatcc tctataaagg
     1981 tctgattacc ataaggcaca tcaaaaccaa ttagaggtag acctgaacca atagcttcca
     2041 tcaaggtcag accaaatcct tcgctggtag aagccgttaa gtagacctca tactggctat
     2101 aaatctgcga aagttccgca tgccccttga gttggatata gtcctctgcc tgatgatttg
     2161 caataatttc tctaagcaga gaatcttctc caccactacc atagatatca aaggttagtt
     2221 ccggtaactc cttatgagct tcaatcacag ctttcacaag ccaatcaatg tgcttttctt
     2281 tggcaagacg tgaagccgta atcaatgaaa atggtttgcg cccttgactt gaatccgtca
     2341 aggaatcaat actgcctaca ggaatggtaa caatctttgg ctgatgctga gtatatttgg
     2401 caaattgctc ttgtagaact tcattttgtc tatcagtaga cacgataaag aagtcaacct
     2461 tatctgcatt ggtaaactga tagtcataat agttattcca aaggatgtag tcctcatttg
     2521 tagcattttc actataatgc tccgcatgaa caactaccgc taaatgtgct gtctgtgctt
     2581 cctcaaacac aacctgacca atgcctgtct ccctatcgag aatgaccaaa tcagacttat
     2641 tcaaattcaa agatttcata aaggcacgca caaaagcttg ctttccatag aaaatcttat
     2701 ccttgaaatg ataaacttct tccttccctt gattcatcaa gatatcatag actggagtcc
     2761 cgtcttcatt ataaaaagtt cgttggtata agactgcaac attgtccttg ggagcaaaat
     2821 actcgctaca ataacgcgta taagaaaagt aatccttccg aatcaggttt cccttaaaaa
     2881 catactcggc atgttgaacc aaatccttgt tctcatcaac caaataacag gttacaaact
     2941 tatcttggtc aaaaaagaat acacgtaaaa ccttgccatt tttttctctg tgactttctt
     3001 caccaccaaa gtaagccaag acatcatcca ctgtcacgct agtaggtgca attttgatat
     3061 ctgtgaaatg attataaagc cagataacct gattatcatc aaaaccaata ttggctgtta
     3121 agtgctgaat attatcggct aaaatcatat ctgtaaagat aaacttagag gacagattta
     3181 atttccgaaa aacaccagca cgataggctt gagcgtattc aacaccgcta ctagcccaac
     3241 caattcctaa atttatattg taaattgtca tattttctcc tcttatggaa aatgagtcac
     3301 gatttcacct tttggagtga cctcaaccag ccccatcagg agattacgca ccatatccgc
     3361 acggatttgt tctttcatag cttcaaagcc cgcgtaggct tcttgatagt actctacgat
     3421 tggatttttc tgactagcag attgaccacc gatagccatg gatagctgtt gtagatagtc
     3481 tacctgctct acccagttgt catcaatggc tttaagcagt gaaagtcgta aaaactgttc
     3541 atataagtca tgttgattaa gtaattcttt cttttcagaa agttctttat caatcacctg
     3601 cttcataaag ctacgaactg cagttttgtc agttacatct atataatctg gaacctcttt
     3661 aacatgaaaa ctaatattgg tcacaataaa gtgaaacagt aattcacgac tagcatagtg
     3721 atcagccgct acctcttctg tatatctctc aatgatatcc acaacaacat cctctaagtc
     3781 acgagaacca tctattagac gattacgctc cttgtaaatc atatcccgtt gaatattcat
     3841 actttcagca tattctagag tctgacgacg tgccgaacgg ccagcactat cactagcatg
     3901 ttgagccttt tcgactagtt tccggtattt acgacctttc aatacttccg gttgagtcat
     3961 atcttgaacc tgatagtctt tgtacttttt atgcacccaa gatggaccaa atttcttgat
     4021 aacatcatcc tctaaggata caaaaaattt actcatacca ggatctccct gacgaccaga
     4081 acggccacga atttgtaggt cgatccgctg actttccatc cgctcagtcc caataacaat
     4141 caagccccca agctctgcga ctcctttacc aagcttgata tccgtaccac gtcctgccat
     4201 agaggtagcc actgtcacag cccccatctg acctgactcg gagataatct gagcctcacg
     4261 cgccgcatta ttagcattta ggacattatg ggcaatccct tcacgaaaca agagagacga
     4321 atagagttga gacatttcaa ctgagcctac aaaaacgagt aagggatttc ccttagcatg
     4381 gtattgcttg atgtactcca aggatgcata cactttttca ggtaaagtga tatatagatt
     4441 atctggatag tcaatccgtt gtctcggacg attggttgga atgcgtacta cagacatatt
     4501 gtaagtttca ataaactctt tttccgcgac cttacctgtc cctgtcatac cagatatctt
     4561 attaaacatc ttaaaaagac tctgataggt gatcgatgcc atagcccgcg tctcaggaga
     4621 taatttgaca tgttccttgg cttcaatagc ctgatggaga cctccttgaa gtttagtcat
     4681 ttccattaga cgccctgttc ccttatcaac cagtaccatc tcatttccac gaatgatata
     4741 gtccttatct ttagtaaaga gcttatgagc tcgaatcgca taaaccaaat gacgagcaaa
     4801 agacgcatgc tcttccttgt ataaattatc aatccctagg aaatcctcag cagacttggc
     4861 ccccttagta gtgagccaaa cctcctcttt ctcctcttta aagatataat cctctccttc
     4921 gaccaaggtt gttacaagtg tatcaatgat cgcatagtaa ttagactgaa cacgaggaga
     4981 acccgcaata atcagaggag tttgtgcact atcaagcaag atatcatcaa tttcatcaat
     5041 aatcacatag ttaaacggtc gtaaaaactt accttcttca ttcgaggcta ggttatcatt
     5101 tagataatca aaacctaaat tactattggt tgtgtagatg atatccgaag catagataag
     5161 cttcttttct tcagctttca tttccttctt tggatcttcc gtaaatggta caccaatggt
     5221 caatcctaga aaacgataaa cttggcccat ttcctcggca tcacgctttg ataaatactc
     5281 attaggagtc acaaccatca ctccttctcc tgaaaaagcg ttcaaataga caggcatggt
     5341 agctgtcaag gtcttacctt cccccgtatt catctcagca acatttccat agtgcatgac
     5401 aatagctccc atgacttgaa catcataggg gaacatccct aaaatccgct tatctgcttc
     5461 acgcaccaca gcaaaagctt caaccaaaat atcgtctaga ctttctccct cggaaagacg
     5521 ctgacgaaac tctactgttt tagctactaa ttcttgatcc gaaagagagg acatcttgcc
     5581 tttcagggca ttaatctgct ttaaaatctt tttcactttc ctaagctgga aatcttgacc
     5641 taaacgtcta aacacttctg atctccttga tagaaaaatg ataaaaagtt aaggactcaa
     5701 atccagcact taaaagagaa acttgataag tataactatc ttctggataa gtaaatatga
     5761 aatctttcgc tttttctacc tttttttcta aaatatcacc atagcggtca aaaaaagtta
     5821 tcttggtata aactccattt tcaggctgac aatcaaaaac cagtgatagt tgatactcct
     5881 gctttctttt taataaggga agctgaggtt gggttcgtgc agcctggtaa ttgacactag
     5941 aaaaccaagt ctttagaatc tcaccagatg gcaatagagg attatacaga cgaacacttt
     6001 tgtcagggta ataagataca gttgttccat acatataagt cccaccaact tctccccaat
     6061 gaatagactg tctctgtgta ataatcatct tttctccctt ccaaaaccag tctctaagac
     6121 cattctataa aagtgcaaaa accaagaaat attggtatct gtatcatcat tgtgtcgtcc
     6181 agcagttcct ttagataaaa tcttcgcacc tgtattacac agataagaca ctaattgttc
     6241 ataggcttgt ggatccattt cttcatcttt catataggat aaaccaaagg ttgtctttga
     6301 aaaatttgct tgtttaaaaa ttttccaaaa acgctgatcc aactccgtca tatcttgaga
     6361 acttgtccca cctgtatgat gaattaaaca atcaaaagct aagttagaga cacccggtgc
     6421 gtccaaacgt ccacgactag ctatagttcc taaattagcc aagggcttac caactatgat
     6481 ggcatggggt tcaaaagaag caccataata gagagccgga aacgttccca tagaaagacc
     6541 tgataaaatc aaatccttat gatcaaagcc taaataatca agatagtgag tgatcgtatc
     6601 ctttactttt ccctctagct catccgttcc gagataaaaa gctcccccct ctaaacgtgg
     6661 atcagaaaat aaaatgaagg gacatccaag agttttcatc ataaagtaac cctcgaatcc
     6721 ttctgcaggt cgataacctg caaaatagac agtcaaaggc ggtttaaaat cacctggatg
     6781 gaagaaatag tttatttcat cacgcttgga atcatgtagg atatttccac caagtacaaa
     6841 cttaccaaat tgttttcgac tccatcgttg gtgaagatta cctagtttga tagttccacg
     6901 acctcttgct tcaacagata tcgagagaaa gtagtctccg tctcgactat ccataaaaag
     6961 tgcttgctcc aagtcttttt cagatactat tacttcttca aagaaatcat caacagaccc
     7021 actccacatt ttacggatta ctaaacgaaa gtcacaattg ccttccttct catattcaag
     7081 ccacaactca atagggagtg ttttttgcac cataatatta taagcccaat aggcaagctg
     7141 ggcaaaatct tgcccaaact caccttccaa actgacataa tccaatcctt gataagaaat
     7201 agctcctgta aaatttggat tgacttgtat cgtcggagga aagagtttat caccataccc
     7261 accgccaaaa agagatttac ttaaatcatt gattagttgt tggggactta aaaaatcaat
     7321 tgcttgtgca catcgttttt ttagaaaatc cacaacctct ctatcattta tttgtagatt
     7381 ctggttataa aataaagtat aaggttcaaa atattttaca taggaaaata agtctctgga
     7441 atactgacca tcttctatta aaactgcatg aaaacggtta atatcctctt tttcaattat
     7501 ttcacgaagg gcttttgatg agtttgggta aaaataatac caactcatat tttcaggtat
     7561 gtcatagtga ttttcccaat tggcaagtcc tatctgtaaa atattaagtt cctttgacat
     7621 ttttaacctc ctctatccat ttctctaatt ttccaagaaa ttgttgtcct gtgtgctcct
     7681 taatcttatc aattgaatat atcaaggact cattccactc cttcaaccta tctgtgtaat
     7741 aatgtgcagc cttagaaaat tctgtaacat ctgctaacaa ataaccattt tttaaatgtt
     7801 caacatagac ggtttcaact aggttgattt gaggaattcc tgcactaatc ccagcaatct
     7861 gtgtgtagag atgaggatgt ctatttaaat ccacaatcaa acggacaaat tctagtgttt
     7921 ttatcaaatc taactcatca ttcaagttaa caaactgtaa gcgtaagtcc tggtgttgat
     7981 tttcttccag aggattttct gcatcaccat aatcaatcgc ctttcccaga ttttcggatt
     8041 gaatgttttc ttggatgaaa gactcaacaa tcccttcaac ctcattcatt tgctcctgac
     8101 tagcagcaaa ggctccaaaa atcacctcag tatccttatt ttcagcgaca aaggacaaga
     8161 cttgaagcag agcttgatta tcaatcccct gctcaaaatc cagttgaaaa taaatgatgg
     8221 attctttctt agtttggctt cgtcccaatc gtaatcgggt gtcaaaagat gataaatgat
     8281 aacattgatg cattcgttca ggatacaact cctgcaacaa tcgtaaacta tcctctctat
     8341 ccaccaaaat caaatccgat ttttcaaaag ttacatctaa atccctaaag gtatcttgag
     8401 gattacgtcc aatgaacaga ctcaacagtt taggattagt actaggtaaa cgatctagta
     8461 ccaactggtc atgatgagaa tgagaaggaa gcataaaaat atcctgatcc ttcacatacg
     8521 tttgcagata attctcaaaa aattctgcca ccagatctcc catattttga taggtaagca
     8581 ttttaaagcg ataacccaaa attggattga cttctacctg tcctccttct tttaaacgct
     8641 ctctgaattg ccactctccc ttgaggttca gatattcttg ataggctgct tgcccatctt
     8701 caaaaaagat aatgctcgat acaaacccac gatcatccac gatatggtgc atatgtattt
     8761 gaccatttgg ttcaaaatac tgtatatcac tgatgaagcc ttcaactcca tgttcaacct
     8821 tagcaaattt cttcccattt ttttgaacga taatcgtaaa gggactataa ataaattcac
     8881 agtcatcatc ccactcaata tctctaatgc ttaaaacttg ggtatggaga ttatgaaaat
     8941 cttgcataac atcaaaaacg gaataagtat ccatttctaa cacaccatgt ctatataaaa
     9001 aataacgtag atgaggctgg taagctaata ctaatagacg agaatctata tcttgctctt
     9061 gaaagagccg aatctggtga aaggtatcat caaactctag acgaaaatga gaaaaatacc
     9121 atggagtgat atctgcatgc catgttcttt ctgacccata ccaagctgga ataaaataat
     9181 acataaaagt ctcctaaatc aaaggtctat aggtctcatt tagccttaaa gccttgacct
     9241 cgtctctaat cgtaaaaatc atgcccccga acatcataaa taagcctgga atcattgcca
     9301 atcgtaataa cttttcatca aacaaaacaa aaagcatggg accacctgcc ataatcacat
     9361 taaagagacc acctatgact gagaaacgaa ggaccaatcg attaataaat cgactagtat
     9421 ccgcacctgg ataaatacca taaatgtatt ctccagattt tttcatacgg tctgcaatct
     9481 cttctccatt catcgtaaca aaagcaaaaa tgatactaaa taaaaataag accgaaatat
     9541 aaacatagac ccacaaaggc tttccaacca taaattcctt tgataaagcc gctaaccctg
     9601 aatgattagg gaaaataaat cccaacaaga tgaacaaata agctggtaca ctaagaaaac
     9661 tcatcacata catataaggc atcccacctg caggattcaa catgatttcg agataagaat
     9721 agcgtttaaa tcgattgtgt aagccaattt tattaacagg aaccaaatag cgagctcgat
     9781 acataagggc aagtaaataa gaaaagacaa gggttaataa agcaagtaac acaataatcc
     9841 ctgttggaat gtgtactgtc tgaaatgttt ccaaaacatc ctgaagaata tttaaaacca
     9901 tactggatag gaggattaca atagaacctc caatccccat actcgcattt aaatctgaca
     9961 accaaacaag aaaaaatgtt cctgctatca gcaatattgt attcattaga acaaccaata
    10021 ttgcagaata ggaggattgt actggcagtc tcaagctaac tgccaaggat tgaatcacag
    10081 caattagcaa ggtcaggtac attttacggc gatcttgtat ttctatagac gtagatgtta
    10141 aacccaaccg tttagaaaaa gaaaacatct gccataaaat catggcggac atccaagggg
    10201 ataatccaac agaaaaaatt gataaacttc ttagattccc acctgttagg gcggctgaga
    10261 aggctagata ggctgttgaa cctcctaaaa aatctttagt atttaggtca acaaaaggga
    10321 gaataatacg acttcccaat acatagataa acagtagaaa taaggtaaat agtccttttt
    10381 ttactgctat tgacgaataa atcttagtca taaaacactc ccctcacctt cattgtttgt
    10441 gatatggtaa ataacaattc ttttatttca acttttacca tttctttgtt ctgcatcaaa
    10501 aaacaacttt aatctgaaac aaatatcttt atattcctca gtatctgtta attgatggta
    10561 ttctaaagtt tgcttataat cttttaaaag attgacaaat cgaatacgca gaacggagat
    10621 atccaaacca gccaagacac aatccgatat tttcttagaa aacacttcaa caatatctct
    10681 tgcccaggaa agatcaaatt ccgttctcat gatgcttcct gaacgtcttc tatacagata
    10741 gagattatcg tttataaaga cgattttaga ggctaaaaga taaaagcgat gcatagttgc
    10801 ttcatcatca aagcggcgac catttgaaaa gtgaacttca ttgaataatt cttttttaat
    10861 caacttaaat gtcggcaata taaaggccga gctattgaat ttccaatctc ctgcttgacg
    10921 gttcataatt tcttgtatag ctaattcttc gacgcaaaaa tcttgccctg ttacataaaa
    10981 ataaaaattc ccgtcacttt cgtcataatt atagtaattc cctataacaa catctgcatc
    11041 cttttcttgg acttgctgat aaagagtttc aatcatattt tcttttacga tatcatctga
    11101 atcaacaatc gtaatgtact ctcccttagc tacactaatc cccatatttt tagcttgtgc
    11161 tgcccccccc ttattttctt gatgcaatac tcgcacacga ttatcttgca tcataaaagc
    11221 atcacaaatt tccccagaat tatccgtaga accgtcatca actaaaataa tttctatatt
    11281 ttgataggtt tgcttcagaa tatgctcgac acactccact aaatattttc ccgtattgta
    11341 tatcggtacc acaacactaa ttaattcact cattactcta tctctatatt cttcattcta
    11401 tccactaaat catctggtct ctccacagaa aaaataccgt catagagtcc atcatccata
    11461 cttttacgtg tgatatcaaa agcgaagatt ttcttgccac tttcttgtgc ccttgtaact
    11521 acattaaaaa cctctccacc tgtattaata tctaaataaa ctatagaatc gtccaatagc
    11581 caatcaattc tactatgtaa tacattttga tatactgtta cattcgtata ctgtgataga
    11641 gaggtcagct cctcagaaca atcacacggt gcagccaaat gaaaatgcca atcaggtaac
    11701 cgttgtacta aatactctaa atgttttata tctgcactcc atgtcacaag catcacttgt
    11761 tttttagact gattgcttct ttcaaaataa tttaaatcgg aacgttgaaa agcaatctct
    11821 gaccaatcca aatctctata aacccaccat aattcacgta gtctagatat actatatgta
    11881 ttccaaggtt tatcatgact agcatagtga acaattgtag gtggattgtc atctaaacgt
    11941 tcacattctt gagcaaggtg ataaatatca acacccacca tataattata tgttttatct
    12001 aaggctagcc aattatcctc aaaataaata tttaaaatac tctgatcccc aagatgaaca
    12061 acttgatttt gctcggccgc taattccaat aaactattga caatagagtg ttctttccat
    12121 tttgcaacat ccattaataa aactccagaa ttaaatccag attttcgtcc ttcataggca
    12181 tagacatcat caacagcacc aattgaatat cctttgagat ctatctcaaa caaagtagct
    12241 agttccccag ttacaatgat atcggaatcc agatacaata ccctatcaga ttcaaccact
    12301 tctatcgcaa aaaatctaaa gtaagaagca taatttatat gaggtcctgt tttatagctt
    12361 tcaaaaagtt ctttatcaat gtgtacactg cgaattgtag aattcacaac ttccattttt
    12421 ctccccaata atttaaacca ttcaggagct atatcactgt tgagaatata aaaatcaaca
    12481 tctctattgt gatacaatac agactttata gtcgtctcta aaggaataag ataggcatta
    12541 tctgccgcta atactattga ttttctcata ctgttctcta cctcatgtaa gatctgattg
    12601 ctgcaaccat ttttttcgga atggagcttg gatagatacc ttcatatgaa atctcagaaa
    12661 gattttcaga gcaagtattg tcgaaagcta tcattggttt tttgtactta agcacaaact
    12721 catatgcatc ttctaatttt cgatcatgat tcaaatccaa atacaaatct gaagctatta
    12781 ctatttgttc caataacatt ggtaaggaat ttggatatac ggtaacatta ggaaaacgcg
    12841 ttaaagctag tagttcattt gccatatttg tataagcaac aatatgaaaa tgaacttctg
    12901 gcaattgctc cgccaaataa tcgattttct cgacacacca agaattcgtt aaattaacac
    12961 attgcaactt aaatatttgt gatttactag gatacttcac actctttgaa aaccattcat
    13021 ttaaaataac agaccaatcc atcaaagagt attcccacca aacttctctt agacgtccaa
    13081 cagaaaattg attccaaggc ttatcctgag aaatatagtg taaaattagt ggcagtggtt
    13141 cgagcggaat atcaaaaatg aattgatgtt taaaggctgc cgccccataa tcatatccta
    13201 tttgaaaatt atattgatct tcaagggaac tatattgatc tttaaacaac atattcaaaa
    13261 ttgactggtc tccttcttcc acattctcat gttctttttc tgttaagtca atcaattttt
    13321 gtcgaatagt ttcagatccc cattttttgt tgttaatcaa gagaacacca gcattgaagc
    13381 cgactcctgc tccaaagcaa gaacgagctg ctgccaaata attttcacct aagtctaatt
    13441 caaacaaatc ggtcaaatca ccagtcacaa tcaaatcact atctagatag agaactttat
    13501 cttctgttac aaaatctgga ataaaatagc gtgcaaatgt catatgattg atatgaggta
    13561 atttattaga ccaattcatt tgaaactgtg agccaattaa cttgcagtca atcaagtcgc
    13621 cccccatctc ttgtaaatat attcttattt gactaaacca ttcctgagga atgtcctgat
    13681 ttagcagata aattttcaaa tgactattgt gtctacagag tgacttcatc gccgtttcga
    13741 tttgtcgaat ataagcgtaa tcacctgcaa atactacagc gcgtttggta tttctcattt
    13801 taaatcctta tcatttattt taaatagtct agtttaatat tcgtgcaaca atctgactgt
    13861 tataggtttc atcatcaata aattcaatat cttggtcgaa attatgttct gcagtatgtt
    13921 tatgagaaaa tttaacctta gttttagctc ccattttcat ccattcatac tctgagtcaa
    13981 tatggcctac atccaaaact tgatagccca tctggcatag attataactc agaacttttg
    14041 ctgtaggacc cagcatacat aaaatcagtc ttccttcagc atgtttcata atttcctctt
    14101 gaatgttatc gacaacggaa taagcattat gagatggaca aataatcctt ttcacagatt
    14161 tgatcttatc aaataaatca tttccaaccc cagagcgaga tgtaatcccc tctacaatca
    14221 gaatatccct attctcccaa atactcttta gattttcaaa ttgtcctttt gccttactct
    14281 tatcttcata atcaatgtat ggacgcgaga taaaggtaga gccataccat gaacccttac
    14341 acaactcttt ataaaaatcc atataaacat tcatatgttc tttccagaat ggtgtagccc
    14401 accaagtaaa gacaaaacga tcgtcaaaag catcaggtaa acaaaccact aatttctcgt
    14461 cactctcaag acccacaata tgttttaatt ggttagctaa ctctagatca tgattttgat
    14521 aaggtatagg caaaccccac atcaaattga cttctccgtc tccaaaacga actaatgagg
    14581 acttattttt gataacataa tccagagtct gatcaattcc gataaccttg attggcttct
    14641 ctggttctcc caaagtctct ccttttatca atgcatgaaa tgcttgaaga agcctttctg
    14701 gatgctcact tgaatataaa tgttgaccat gatttccatt ttgtgaagta taaaatgcca
    14761 gcattggttt attcaatgat gatatctcct tgacaacctc actagtagaa ttgtgtaggt
    14821 taatatccaa ataaacatcc atttgagatt tgagttcttc aaattgatcg cttttcactt
    14881 caggatatag cttaacattt ttatattttt ttgctagttt ttgtaacatt ggtcccataa
    14941 ctgtccaagc tgcgatatgg aatgttacca taggaaaatt cttaacaaga taatctattt
    15001 tttgcaattc ttgagaattt gtaaatgtta ggcaatggaa atcactacct tcataacaac
    15061 ttaggaatct tccatctctt ctgtaatctt taatcgcttg aaccatgact gaaacttcat
    15121 cttttttgaa tactagttgg ccagtattcc catgttcagt cgtatcaaat gatagaattg
    15181 gcttttctaa gatcttcata tcctctaaaa tagtacctac cacatgactg tagttaatgt
    15241 ccagatataa atctacactt ctctccagct tatctaatac aggaggaaca atctgtggat
    15301 gcaatctcac attattatat acagctaatt tttttaattt atctcccata tccgtccaag
    15361 cagcaatatg aaataccaca tctggtaaag ctgtgactaa ctcttctatt ccttctaaat
    15421 cttgggaatt tgtcaaagtt aaacaagaaa attccttatc taaagacgat gtcagttcaa
    15481 actcccctat atgatgttgt aaaattttag tccattccaa atcatgaaat tcccaccata
    15541 aatcacgata acgattggct atcaaggtgg tccagggttt tctgtaagac acaaaatgaa
    15601 taatactagg aggtactaac tcattaaaat aattttccca tttattataa aaagcagtta
    15661 catcatgacc cacttgaagg ttaaattctt tatccagctc taaccaatca tcttgtaaga
    15721 cctgattaaa aatcgtttga tcaccattaa aatgctcgaa acggccttct tcaacttcct
    15781 tcattgtaac aatgctctgt tcaattagtc gttcttttaa tttctcttga cgccattttt
    15841 tattgttgat taatagaaca cctgtattaa atgtaattcc atctgtatct ttaactgctg
    15901 cgagtgattt ttcttctaaa caaatactaa ataatttctc taaagaagta tttacaatca
    15961 aatcactgtc taaatataaa accttatctt cttggatata atctgcaata aaatatctag
    16021 cataggtaat gctactaatg tggtcttgct tttcccaatc ttgaaacaca gtttgttcag
    16081 gtagcttcac atcgataatc tcactaccta acatgcgagc tatttttcgt ggctttcgaa
    16141 accaatctgg catgatatct tgatttaaaa tataaatctt aacatctcga ttgtggtata
    16201 gaatagattt tatggttgtt tctaactgcc tggtgtaatt acgatcacca gctaatacaa
    16261 ttgttttgtt catttcactc ccttaatcaa ttcccaagtg ataaatcgca tctaccaata
    16321 gctttttagt gaaatagccc tcttttagca gataactaaa ggtctttatc ctattcgtca
    16381 tttcttgata ttcttgtaga ttcattttat caactatctc atgaacttcc tctagactat
    16441 tcgccacaaa gcctaagcct tgatatacta taaatttagc agttgacaag ctacttggta
    16501 caatgactgg gatgcccgct gtcagatagg tactcacctt atgagatata ttcaaggtat
    16561 agtattggtt actttctccc tcattttgat gggttcccca gacaaggcca aatccaccct
    16621 ttgataattc tagcaacaat tcctcatctt ttttccatcc ttcgatgctg agatttctag
    16681 cactagaact agcttcccct ttatttgaaa atactctcaa aggcgtatct tgagaccaat
    16741 tttgtaagtc tggaaaacgc tctaaacttc cagcaaaaaa aagttctttt ttaaaagcag
    16801 gggtgtataa ggataaatca tgaggatgat cccacatccc ttgaatgaga atcttctttg
    16861 ttgtcaagcc ttcttctatc aggcgttctt tcatctgttc agatggaaca atcaaaatat
    16921 ccgatagatt atacatatac agatagtctt tcatgagata gtaattacta tcaaacatga
    16981 gaggaacaac atcatggata aaacaaataa ttttcacctg catatccttc agcttatcaa
    17041 acaagagacg atcaaactca aagccattcc aagttggaga ctgaaaaact aggatatctc
    17101 caatagagat actggccata atgccatcca gacgcttatt catttcagaa ggactatctg
    17161 aagaaatatt gtaaaaatag atgccaacct ctctaaatcc cagttgactg gctatctttt
    17221 gaacagcatt ttgcgctaag ataaccgtac tatcaccagc catgccgtat aaatttgtta
    17281 aatgtagttt catattatgc tatctcattc taatcatcat attttttgac aactaacgat
    17341 gggactcact tagtttattt tggatgcttt ttaccatttc atcaacatta tctactgcaa
    17401 atacttgatt ctctccatta gaaaaatggg acgtactttc aaacgaatag attgggttcc
    17461 cttgtcgtac aatctcttgt aaggcatcgt ccaaagctgg tccataatta atatccaaat
    17521 aaaaattagt ttgattgatt agtgtttctt tcattttggg gtcaacacag ggatatatat
    17581 aaagatttga atatctctgt aattccacaa tattcggaga aaaataagtt ggtgcagcaa
    17641 tgtggaattg aacattcggt aactgttcca gaagataagg tagcccttct atatcacctg
    17701 tgtttgtaaa aatactggca tgacatgtaa tcggtttgat taacttctca aaattttctt
    17761 gaagtatttg attatctaac aaaatatcat tccagtttaa tccgtagtag aaccaccaaa
    17821 tatcacgaaa acggttgaat cgatagtgac tccaaggttt attctgtgtt gtatagtgaa
    17881 taatattggg aattccttca aacaaatgat accattcatt atctcctaac gaatgtcggt
    17941 aggtatcata cccaacctgt aaattgtagg ataaactcaa tttcttccat ctatctttga
    18001 acaacatatt tagaatttct tgatcgccat atacatgttc atgatgctta attgttaaat
    18061 ttaataattg attttgaata tcatcttctc tccacctatc cgtatcaata agtaaaactc
    18121 cagaattaaa tccttcagac gtgtttggaa tatccggaac ggctgcaaga ggacagccat
    18181 ctaaaggaaa ttcaaaaagt gaggttaaat ctgcggtcac tattatatca ctatccaaat
    18241 aaagaactct tttttcaaaa acaatagttg ggataaaata tctaagatag gtagcagaac
    18301 taagatgagg ggtgggaaga tgaaattgat ttattagact ctctgtcacc ttcacattca
    18361 caatctccga acccaaaaca gacaaccttt tatccatcaa ttgaaaccat tctatgggaa
    18421 ggtcactgtt aaaaacataa aatttcactt ctttattctt agaacagata gattttatgg
    18481 ttgtttccac tttatccatg taatggttat ctgctcctaa aacaattgct tttttcattt
    18541 cgtcccctat aaattcctaa gtatttctcg atacatacac aaagcgtttg actcaccttc
    18601 ttcgacatct gatttcgtat ctaaacgcca ttgaataagt ctcttaattt ctgctatgta
    18661 aggagtcgaa tcaattcctc ttccaatcaa aaaaggaatt cgtccaagtc ggatttccac
    18721 atcatccatt agttgtctct ctgtcctaac ttttcccacc atcgattctg agtgtactct
    18781 ataattataa agtgctctat gaatatataa gcagctagtc atagttaaat acaatttaaa
    18841 actacactca aaatcctcac caaatctacg ttgctcgtta aataatacct cgtcaaataa
    18901 aaaacgttta aatagtttac cccaagaaac tgtgtaagaa ctatcataat tttcaatatt
    18961 tggaagcaca gttatcaatt cctgactagt ccagattttt tcataataat cctgttccca
    19021 aacatgcata taataacaat tatcagacat actaaacttt ttatatgatc ctatcacaaa
    19081 atccgtatca tactctacta tttttgaata tagtacttct aaatagtccg attccaacca
    19141 atcatcagag tctacaaaag caatgtacgc cccccccgaa cattcaatac ctaggttacg
    19201 agctgatgaa agaccgccgt ttgctttctc aaaatatttg aaacgagaat ctttctctac
    19261 aaattcttca catattttgg atgaatgatc tggagagcca tcattgatta ataaacactc
    19321 aaaattttga tacgtctgat tctgaatgct atctaaacac tgtcgcaaat atttttcaac
    19381 gttgtagatt gggactataa tactaattaa ttcgtctgcc ataaacttat tctcctatga
    19441 attgtctaat agcctctacc atttcctttg gctccgttga aggcaatatc tgacttcgat
    19501 tatttgtatc atgactcgta ttctcaaaag caaatatcgg tttcgatagg ttatgaactt
    19561 ttgaaataat attatctatt tcatgattat gattgatatc taaataaaaa tctaacttac
    19621 tcagcacttc ttgagattga tacggtgtat aattgggata aagagataca tttaaaaaat
    19681 ggttcaacgc ttgtactctc ggtccaaaat aactgtgagc aaaaatatga aaatggacat
    19741 tcggaagttt ttctactaga tattctatat gttccaactc gtgcgtatct gtaaagatcg
    19801 ctgtatgaaa taaactaact gttgcaattt cactaaacgt agttggtttg ttatcaactt
    19861 gcgacaaaat agtttgccaa tccaaaccat tataaaacca ccacaattct ctatatcttg
    19921 tttttaatga atcattccac ggtttatctt taccttcaaa atgaataata gcaggtttat
    19981 agttttcatc ccaactattt aaaaaccact ctggcttttg agcccaataa cccaatgtat
    20041 caagtccaac cataaaatta taatgaggag atactttctt ccacttattt tcaaacaata
    20101 gatttaagac tccctggtca ccatagattt cttgatgttt ttctgcagtc aactctaaaa
    20161 gattttgaca aatattatca gttttccact tatgaacatt taccatcatc attcctgcat
    20221 taaaaatatt tttataccac ccatctggaa cggcgattat ataatttcct tcgaaatctt
    20281 tctgaaataa tggatttata ttcccatgaa taaccatatc acagtctaaa tacacggccc
    20341 tatcttcttt tacaaattct gcaataaaat agcgaaaata agtcatatac ttgatgtgtt
    20401 catcaggagt agaaaaatac tttacttttt ctgcatcaat ttctatattc aaaatttcac
    20461 agttaagttt ttctaatctc ttctccatca aataaaacca ctctttgggg atatcttcat
    20521 taaaaatata aaatttcaaa tctctattat ggtaacaaat agatttaata gttgtttcca
    20581 atttgtcacg ataattatta tctgccccta aaacgattgc tttttttgta tccataactc
    20641 caaattatct tctttctttt acaacaagat ttccattatt ataaactaca ctgtttgatg
    20701 gaatatcatt gcgtatgaga caacctgctc caataatggt attatcccca atcgtcactc
    20761 cttttaaaat cgtgacatta cttcctatcc agcagtctct gccaactcta atcggcgctg
    20821 tagtccactg ccacttttca atcttttcag cggtataaat atggtcgtga tcataaaaac
    20881 gaacaccctc tcccatcatg gtaccagctc cgatttcaat tctttccata cagttaaaac
    20941 tacaagagtt gttgataaaa acaccatcat tcaggattaa cttaccagaa gagacatgga
    21001 aattttcaaa atttctgcag atgacatttg ctcctacaat taaatccgct ttattattaa
    21061 tttgaaagac attccaagtc ccatcttgaa tgattttctc ttgatgattg gtgcctactc
    21121 tgacttcatt cagatagtct ctcactctag aaaccaattt gtctggtgta cttgatagaa
    21181 aaacttcctg cccctgattt ccatggactg tattgtcaaa tgcaaagaca gattttccag
    21241 cctgtacaaa cttggagaca atagcatcta cttcttgaaa gtgattgata tctagtaaaa
    21301 agtcacaggt atcgactaga aagtttagct gttcttcatt tgtaatcgtt cggagacgga
    21361 cattatagtt cgtttctaag ctacggattt tctcggaaaa ttgaacaggt gctgcaatat
    21421 gaaaacagat atttggcaag gattcaagga gataatccaa ctcttcaatc tgatcactaa
    21481 ccgtcaaaat cagagcatct cctactaaat gatttttctt catttgctta tttctctcaa
    21541 tttctcaatc attgcttgaa cttggtaaac agcatatgcc tcctgaccta cttcataggt
    21601 tttagtattt tcaaaggata agataggctt gccaagatta gcaaattgat cgagaatttc
    21661 ttctgtcttt tcgccatgat taatatctaa aagtacttga ctggtttcta ccaattcatt
    21721 atcgacatct accaaatagt gaattccgtt aaatatagtc acgtttggat aaattgtcat
    21781 ctgagccaat cgatcactaa ctattactct agctgctatc ttaaactgaa tatcaggcaa
    21841 ggattgaacc aatgtctcaa tttgttcaat atggtctgag gcagtataga ttagacaagt
    21901 gaaaggttcc tttattggat agatgtgaga tctttgtaat ggatgtaaat gatggttttg
    21961 tcccaattct gtccattcaa gcccatgata gtaccaccaa acttcacgat aggtttgggc
    22021 cgccaaatct ttccacggtt tccgatgaga aagatagtga ataatagcag gataatcctg
    22081 accctcaggc aattgataat cagcgaactg tttatgaatg acaatatgat tataatcaaa
    22141 gtccaattcc aaccatttat gttcaaaaag catattcaaa atactttgat cagcctgttc
    22201 caccttatta tgccattcat tggttaaatc aattaatttt tgggtcatat tctctttttt
    22261 ccaaaaagca ttgtttacca agagaacacc ggcattaaag atttcttgac caaaataagc
    22321 tctgccccca aaatctctaa cagcagccaa aggataatct tgtaagtctg tagcaaacaa
    22381 gtcgtccaga tttttcgtta caagtaaatc acagtccaag tagagggcct tgtcttcttg
    22441 cacgaaatca gctatgaaat agcgtaaaaa gactgtgtaa ctaatatccg atttataaca
    22501 tgaaatttgc tcagaagtta cccgacaatt aataatttct gagtcaaact tctctaatcg
    22561 cttatttaat tgtttgatcc attcatttgg aaaatcgcta tgaatcaaat aaaaacgaag
    22621 cgagcgattg tggtaacaga tagacctgat tgtcgttaaa acttggtcta cataggcata
    22681 atttgctgct aggacaatgg ctttcttttc acttgattct tgtaccgtta actgatttaa
    22741 aagtcttttt ttcatttcaa actctttata cattgctgtg tcagataaac cactagctta
    22801 accgttggcg agactgactt ccaacatctg acgataaact gccaagtgtt tctctagagg
    22861 atatcccata ttagctagta gcgtaatacg ttcagacata gcatcaacta aggcgtgcat
    22921 ccacttttct gtccaaactc ttgataaact accttttcta atccgataag cataaagacc
    22981 tttatttaaa taaattacct tttccgataa taaatatacc ttttgattga ggtaaccatc
    23041 ttctcctaat ttacccatgt caaagcgcaa ctgctcaaac aatcttgcct tatagagttt
    23101 accacaagca gatatcaaag caaaactctt catttcttga gtttcataca agttctcaaa
    23161 gatggaaaca ttgtcatata ccttatcata ataggagtct cctgatatat gaaagtagaa
    23221 cattccttca ctttcgttga aagaatagta attcccaact gcaatatcag cttgatattc
    23281 tgttattttt ttatataggg tttctacata atctaactca atccaatcat ctgaatccac
    23341 aaaggtcaca taatctccgg acatattttc cagaccggtg tttcgtgcag ctgacagccc
    23401 agcattttct tgttctatat agagaattcg gtgatccatt tctgaaaatt ctttacaaat
    23461 ttcacctgaa gcatccgtag aaccatcatt aacgacaaca atctcaatat ttttatatgt
    23521 ttgagtaata atactatcta ggcacttcct cagatagttt tccacattgt atactggtac
    23581 aatgaccgtt attttatcat ccactagcaa ttttctcctt gatttatgtg cgcgagttag
    23641 tttagcctaa ctttacaggt tgtcttactc ttcttcatca cgtttacggc gtttcgcaac
    23701 caatccaata cctgtaacag ctgctagaac tccaagtaac acagatccag ttgacgactc
    23761 agtacctgta ttaggcaatt ctttttggga tttacctgtc gatccagaag tatttccaac
    23821 ttgtgagttc gaatggtttg ctgaatttga aactgatgta cttgctgaag ctgacgcact
    23881 ggttgacgct gactcagaag ctgatgtgct tgcactggtt gatgctgaag ctgaggcgct
    23941 ggtacttgct gaagccgacg cacttattga tgctgaagcc gatgcactcg ttgagaccga
    24001 ttcagaggca ctggttgacg ctgaaactga cgcactcgtt gatgctgaga ctgaagcact
    24061 ggttgacgct gaagccgatg cacttgttga ggccgattca gacgctgagg tacttgctga
    24121 agctgaagcg cttgtcgatg ctgagactga agcactcgtt gacgctgatt cagatgctga
    24181 tgtgcttgat gaagccgagg cgctggtgc
//
LOCUS       DBERMM010000027        23054 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.027, whole genome shotgun sequence.
ACCESSION   DBERMM010000027 DBERMM010000000
VERSION     DBERMM010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 23054)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23054)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23054
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.027"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(409..615)
                     /locus_tag="ACL8AS_001373"
     CDS             complement(409..615)
                     /locus_tag="ACL8AS_001373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229220.1"
                     /translation="MLKKYFSKYKWTDLFWILFVILTCLYIGNHDLFTLNHQEFSFRG
                     SFWGLVLTLYHLLFIDKFVISNRK"
     gene            737..1264
                     /locus_tag="ACL8AS_001374"
     CDS             737..1264
                     /locus_tag="ACL8AS_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229221.1"
                     /translation="MLIVSAIPSVSAVYASEQVSQIETNMELQPVTSLTEEQINTLAN
                     EIQSFHPDVSQQWIKEVINRQLQGDYTIPPTYSPFRAAWQGITVNQMGALLDTAIALA
                     LGGTTAGLANLIKVKGKHAAKSAIRSAISRYLGSWFVNDVALEFAMNLLSPGTYLAQL
                     WDKNDAIPNNGRINF"
     gene            complement(2309..4567)
                     /gene="glgP"
                     /locus_tag="ACL8AS_001375"
     CDS             complement(2309..4567)
                     /gene="glgP"
                     /locus_tag="ACL8AS_001375"
                     /EC_number="2.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004645 - 1,4-alpha-oligoglucan
                     phosphorylase activity [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan family
                     phosphorylase"
                     /protein_id="HGS1229222.1"
                     /translation="MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTG
                     KKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGL
                     GRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSR
                     SYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARN
                     LTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDT
                     HPSMVIPELIRLLTARGIELDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHL
                     VPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSEL
                     KAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYED
                     KAAVKEKLESIKAHNKRKLARHLKEHQGVEINSNSIFDIQIKRLHEYKRQQMNALYVI
                     HKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVV
                     MVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAE
                     LVGEENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERL
                     ERLYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRT
                     IAQYNEDIWHLN"
     gene            complement(4593..6125)
                     /gene="malQ"
                     /locus_tag="ACL8AS_001376"
                     /pseudo
     CDS             complement(4593..6125)
                     /gene="malQ"
                     /locus_tag="ACL8AS_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847831.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004134 - 4-alpha-glucanotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="4-alpha-glucanotransferase"
     gene            6660..7931
                     /locus_tag="ACL8AS_001377"
     CDS             6660..7931
                     /locus_tag="ACL8AS_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000095461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HGS1229223.1"
                     /translation="MSSKFMKSAAVLGTATLASLLLVACGSKTADKPADSGSSEVKEL
                     TVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPY
                     DRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVK
                     DAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYTYGLLAGNGAYVFGQNGKD
                     AKDIGLANDGSIVGINYAKSWYEKWPKGMQDTEGAGNLIQTQFQEGKTAAIIDGPWKA
                     QAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEASQKFVDFLVATEQQ
                     KVLYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKNTQPLPNISQMSAVWDPAKNML
                     FDAVSGQKDAKTAANDAVTLIKETIKQKFGE"
     gene            8042..9334
                     /locus_tag="ACL8AS_001378"
     CDS             8042..9334
                     /locus_tag="ACL8AS_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000414940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HGS1229224.1"
                     /translation="MEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFL
                     ALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRIN
                     NGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLP
                     PNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQP
                     FIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALI
                     PWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNI
                     TFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTG
                     TSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV"
     gene            9336..10178
                     /locus_tag="ACL8AS_001379"
     CDS             9336..10178
                     /locus_tag="ACL8AS_001379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001065636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HGS1229225.1"
                     /translation="MNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNV
                     SAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYAYSRYN
                     FLARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHNWFLIFLYVGGGIPMNAWLM
                     KGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAFMGPFGDYILSSF
                     LLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFFLQKNFVSGLTSG
                     GDKG"
     gene            10431..11231
                     /locus_tag="ACL8AS_001380"
     CDS             10431..11231
                     /locus_tag="ACL8AS_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1189 domain-containing protein"
                     /protein_id="HGS1229226.1"
                     /translation="MLPYPFSFFSSILGFRKPLSKRFGLNWFQLLFTSIFLISLSMVP
                     IAIQNSSQETYPLETFIDNVYEPLTNEVVQDLSEHATIVDGTLTYTGTVSQASSVVIG
                     PSQIKELPKNLQLHFDTNELVISKESKELTRISYRAIQTESFKSKDSLTQAISKDWYQ
                     QNRVYISLFLVLGASFLFGLNFFIVSLGASLLLYITKKSRLFSFRTFKECYHFILNCL
                     GLPTLITLILGLFGQNMTTLITVQNILFVLYLVTIFYKTHFRDPNYHK"
     gene            11241..12227
                     /locus_tag="ACL8AS_001381"
     CDS             11241..12227
                     /locus_tag="ACL8AS_001381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HGS1229227.1"
                     /translation="MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKEL
                     NYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIAT
                     GKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
                     VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNR
                     IYFADEFLEEKGYKFSKRLFKHDPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDS
                     VNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQLIAHKIIEK"
     gene            12369..12662
                     /locus_tag="ACL8AS_001382"
     CDS             12369..12662
                     /locus_tag="ACL8AS_001382"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229228.1"
                     /translation="MKIKVQTRKLAAGCSKHCFEVVDRTDEVSSKHGFEVVDETDEVS
                     SKHGFEVADETDEVSSKHGFEVADRTDEVSSKHGFEVADRTDEVSNIYTVRRR"
     gene            complement(12698..13639)
                     /locus_tag="ACL8AS_001383"
     CDS             complement(12698..13639)
                     /locus_tag="ACL8AS_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HGS1229229.1"
                     /translation="MKQTKRIKRWRYYLRRFAYQIKILRVLQSISREKYDEKISASLV
                     YGFLSAVAVNFFFQPGHVYSSGATGLAQIISALSNHWFGFHIPISLSFYAINFPLMVL
                     AWYQIGHKFTVFTFITVSMSSFFIQFVPVATLTEDPIINSLFGGVVMGLGIGFALRNN
                     ISSGGTDIVSLTIRKKTGKNVGSISFLVNGTIMLIAGLTFGWKYALYSMITIFVSSRV
                     TDAVFTKQKRMQAMIVTNHPEKVIEKIHKKLHRGATMIHDAEGTYNHERKAVLITVIT
                     RAEFNEFKQIMTQVDPSSFVSVSENVHILGRFVEIDN"
     gene            complement(13617..15380)
                     /gene="aspS"
                     /locus_tag="ACL8AS_001384"
     CDS             complement(13617..15380)
                     /gene="aspS"
                     /locus_tag="ACL8AS_001384"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016874 - ligase activity [Evidence IEA];
                     GO_process: GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HGS1229230.1"
                     /translation="MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREG
                     IMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIV
                     LNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEF
                     IDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKC
                     FRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITEGLIARVMKETKGIEVTLPFPRMKY
                     DDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEALAVKAIVVKGAADNYSRKDI
                     DKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADT
                     LEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTFPQ
                     EETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSAEEANDQ
                     FGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTV
                     ALKQLEELSLQVEEDETNKTN"
     gene            complement(15499..15690)
                     /locus_tag="ACL8AS_001385"
     CDS             complement(15499..15690)
                     /locus_tag="ACL8AS_001385"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229231.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDETDEVSSKHGFEVVDETDEVS
                     NHTYGKATLTWFEEIFEEY"
     gene            complement(15697..16530)
                     /locus_tag="ACL8AS_001386"
     CDS             complement(15697..16530)
                     /locus_tag="ACL8AS_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1229232.1"
                     /translation="MKQDERKALIGKYILLVLGSVLILVPLLATLFSSFKPTKDIVDN
                     FFGFPTNFTWDNFSRLLADGIGGYYWNSVVITVLSLLAVMIFIPMAAYSIARNMSKRK
                     AFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGY
                     IKISIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVL
                     NRDSKMWTLPLFQYNYAGQYFNDYGPSFASYVVGIISITIVYLFFQRHIIAGISNGAV
                     K"
     gene            complement(16544..17410)
                     /locus_tag="ACL8AS_001387"
     CDS             complement(16544..17410)
                     /locus_tag="ACL8AS_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1229233.1"
                     /translation="MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLT
                     YNYKFVGLNNFKLLFMDPKFMNAIGFTAIITIAMVVGEIALGIFIARVLNSKIKGQTF
                     FRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFLQTSLLGTKWGAIFAAAFV
                     LLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSMVFILA
                     LKGGLTAFDQVFAMTGGGPNNATTSLGLLVYNYAFKNNQFGYANAIAVILFLLIVVIS
                     IIQLRVSKKFEI"
     gene            complement(17424..18683)
                     /locus_tag="ACL8AS_001388"
     CDS             complement(17424..18683)
                     /locus_tag="ACL8AS_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HGS1229234.1"
                     /translation="MEWYKKIGLLVTTGLALVGLGACSNYGKSADGTVTIEYFNQKKE
                     MTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEW
                     AKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKV
                     PETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQ
                     PNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAI
                     TAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPE
                     VMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTM
                     NYVLTGDKQGMVNDLNAFFNPMKADVD"
     gene            complement(18775..20937)
                     /locus_tag="ACL8AS_001389"
     CDS             complement(18775..20937)
                     /locus_tag="ACL8AS_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000538915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="HGS1229235.1"
                     /translation="MGVRIENNLFYVESKNLSLIIENRNGYLLLKHLGKTIKNYKGSN
                     SVYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHSVTEVTDFRFVE
                     AKILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLD
                     NNSNQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGAS
                     GHAQTPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSW
                     KLAPEEYFETPVALVTHSDQGLTGISHESQNFVLKHIILSEFSKKERPILINNWEATY
                     FDFQREKLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLI
                     SAIHERGLQFGLWLEPEMISVDSDLYRQHPDWAIQVPDYEHTYSRNQLVLNLANPQVV
                     EYLKSVLDQLLSYHEIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLT
                     EKHSHILFESCSGGGGRNDLGMIRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGA
                     HVSAVPNHQMGRMTPLETRGHVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPV
                     VQLGQQYRLINPDTASNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLY
                     KLQENGEVYSGAELMYAGLTVILSQGDFLSRQYIFRKL"
     gene            21045..21905
                     /locus_tag="ACL8AS_001390"
     CDS             21045..21905
                     /locus_tag="ACL8AS_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HGS1229236.1"
                     /translation="MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYIT
                     KGQGKFHYKGKIVNLKEGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKSPDYFALS
                     QISDQSYLIQSETCHTQTTAKLISDIVRFAQITKSSELAQLHIMGQLHELMFHLGTIA
                     PNQKKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSP
                     KEYLLYVRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQTPSHTRKEYS
                     QYQLVRKATL"
     gene            21902..22837
                     /gene="birA"
                     /locus_tag="ACL8AS_001391"
     CDS             21902..22837
                     /gene="birA"
                     /locus_tag="ACL8AS_001391"
                     /EC_number="6.3.4.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional biotin--[acetyl-CoA-carboxylase]
                     ligase/biotin operon repressor BirA"
                     /protein_id="HGS1229237.1"
                     /translation="MKSYQAVYQILSKETDYISGEKIAEKLSLSRTSIWKAIKRLEQE
                     GIEIDSIKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEANT
                     LYLASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVAGAVYKAIKNL
                     TLIDVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDIIIGVGINFTIKDFPQELKA
                     KAASLFKATAPITRNELIIEIWRAFFETPAEELLYLYKKQSFILGKEVTFTLEQKDYK
                     GLAKDISENGKLLIQCDNGKEIWLNSGEISLNSWK"
     gene            complement(22963..23050)
                     /locus_tag="ACL8AS_001392"
     tRNA            complement(22963..23050)
                     /locus_tag="ACL8AS_001392"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(23014..23016),aa:Ser,seq:gct)
BASE COUNT         7069 a         4891 c         4262 g         6832 t
ORIGIN      
        1 atctgcaacc tcaaagctgt actttgagca acctacggct agtttactct ttgattttca
       61 ttgagtataa actagacttc gcaaaagtag aaaacttacc gaaaatcttc aatatgacaa
      121 aaacgtataa gaacaggtac acaaacctta atcttatgcg ttttgttata gtttccatac
      181 gcattaaggg gaaatagttg aaatcagttc ttttaataac cattgaatac catatactac
      241 atttacccca aatatgatat aggccgtata aatcaagtat ttcgattttt cccgcctcaa
      301 agaatagatc ttatacaaaa taaataaatt taaaataata aataatagag acaaaatctt
      361 cctccaaaat caatcctaaa agtacacagt caagcatagc tctaatcttt attttcgatt
      421 cgaaattaca aacttatcaa tgaacaataa gtgatataag gtcagtacca aaccccaaaa
      481 gctaccacga aaagagaatt cttgatgatt gagagtaaac aaatcatggt taccaatata
      541 gaggcaggtc aaaataacaa ataaaatcca aaataaatcc gtccatttat attttgaaaa
      601 atattttttt aacataatag catatttttc ttgactataa taacagtata taataaaatg
      661 taagcagata caaataaaaa ggagaaaagc tcatgaacaa attaatgaaa tttatttcgg
      721 ttttttgacg tcaattgtgt taattgtatc agcgattcca agtgtttcag ctgtatacgc
      781 ttctgaacaa gtatcgcaaa ttgaaacaaa tatggaactt caacctgtca cttctctaac
      841 agaagaacaa atcaatacac ttgcaaacga aatccaatct tttcatccag acgtctcaca
      901 acaatggatc aaagaagtaa ttaaccgaca attacaaggc gattatacaa tcccacctac
      961 atactctcca tttagagcag cttggcaagg tattacagtt aatcaaatgg gtgctctatt
     1021 agatactgca atagctttag ccttaggagg aactactgca ggccttgcaa atctaattaa
     1081 agtaaaagga aaacatgcag caaaaagtgc tattcgttca gcaatttcta gatatctagg
     1141 tagttggttt gtaaatgatg ttgctttaga attcgctatg aatttattat caccggggac
     1201 ttatttagca caattatggg ataaaaatga tgccattcct aacaacggaa ggattaactt
     1261 ttaatcatga gatatacaat aaaattaatt gggtataacg tattttcgtt gtttatattc
     1321 tttatcttat caatgttgtt taaagttccc tttaggtggt ggatcagcat tgcaatgacg
     1381 acttcgtcgt acattgtata taattactta aagaaaaaga gagaaaagga atgatcttat
     1441 accagatcat tccttttctg ctttctgtaa atccctcgga gtgtgtttgg cgctttgata
     1501 cgaagtgtca aagctgtata aacgttacta tttccaaaaa agtaacagaa aattcctgct
     1561 ttgtaggact gctttgggtg agtaatagac atgtcgactc accctatctc ctgatggcga
     1621 aaagaattta gcaatgatgc aagttgttct gaactcgaga aaaaacatgc cgaaatcgaa
     1681 gaaaagcgtg cagaacttga agcgaagaag caagaaatgt tgaagcgctt ggataaatag
     1741 aatttagaaa acagaaaaaa ctaaaaagaa tgtagggttt atttccctac attcttaaaa
     1801 taacttagta cataaatgac aatgctgcca ctgccgtcaa tattgcaaaa actattttcc
     1861 aaattttttt attttttcca aaaatcttat caggtaacaa gcttattaca agaaaggtaa
     1921 taaacaacac caatttaagt gtgtatatca taaaaacacc ttctttccta caattatatt
     1981 ataatacttt atgtaagcga atacaagaga tatgaggtaa ccaactacga aaaaatataa
     2041 ggctgaagac agtaaaaacc agcatttaaa gccttcactg tatctaggat ttccctattt
     2101 ttagacaaga ttgacccaaa tccacagcat ttaaaaaagc gaatttcaat cgaaactcgc
     2161 ttttttacaa gatgtattag tataaatttg tatcttatac tcaatgaaaa tcaaagagca
     2221 aactaggaag ctagccgcag gttgctcaaa gcaccgcttt gaggttgcag ataaagctga
     2281 cgtggtttga agagattttc gaagagtatt agttcaagtg ccagatgtct tcgttatact
     2341 gagcgattgt acggtcagat gagaagaatc ctgctttaga aatgttaacg atgactttat
     2401 ccaaccatgc gtcacggtct tcgtagtcag caagcatttg ctctttgact ttgatgtagt
     2461 cttccaaatc aagaagagtc atgaaccagt ctttgttgat caattcattg taaagacgtt
     2521 ccaagcgctc tttgtttcca gctgcaagaa ctgcatcact aacgatgaag tcaaccaatg
     2581 gtttgatagc ttcacgagcg tagaattcgc ttgatttgta agctgctttt gcgtaaaggt
     2641 cgataacagt ttctgaatct tcaccgaaga tgtagatgtt ttcttctcca accaactcag
     2701 cgatttccac gttagcaccg tccatagtac caagtgtcaa agctccgttc aacatgaatt
     2761 tcatgttacc agtacctgaa gcttctttag aagcaagtga gatttgttct gagatatcac
     2821 atgctgggat aaggaaactt gctgcagtaa cgttgtagtt ttcaaccata actacttgca
     2881 agtgtggagc tactgctgga tcgttagcaa taacttctga catgcaaagg attaaatgga
     2941 taatgtcttg agcgattgtg taggctggag ctgctttacc accaaagaag attgtgattg
     3001 gacgagcagg gatgttacca gctttgatgt caaggtattt gtggatcacg tacaaagcgt
     3061 tcatttgttg gcgtttgtac tcatgaagac gtttgatttg gatatcaaag atagaatttg
     3121 aattgatttc cacaccttgg tgttctttca agtgacgagc caatttacgt ttgttgtgag
     3181 ccttgatgct ttccaatttt tctttgacag ctgctttgtc ttcataagac aaaagttttt
     3241 caagctcatc tgcttcatgg tgccaaccat ctccaagaat ctcatctaag tagtgagaca
     3301 atcttgggtt agcatgcata agccaacgac ggaaagtgat accgtttgtt ttgttgttga
     3361 acttttctgg gtaaaggtcg tagaaggctt tcaactcaga atttttcaag atttcagtat
     3421 ggagtgctgc aaccccgtta acactgtatc cgtagtggat atccatgtga gccatgtgaa
     3481 cacgtccgct ctcatcgatg atttgaacag ctggatcttt gtactctgcc ttcacacgac
     3541 ggtccaattc ttcgatgatt ggtaccaagt gaggaaccac ttcttgcaag aattcaagag
     3601 gccatttttc aagcgcttca gcaaggattg tgtggttagt gtaggcagtc atgctacgaa
     3661 caattgagat tgcttcgtca agctcgatac cacgtgcagt taaaagacga atcaattcag
     3721 gaatcaccat tgatgggtga gtatcgttga tttggacaac tgcgtagtca gcaaggtcat
     3781 gcaagttgct tcctttttcg attgcttcgt cgatgatcaa ttgcgcaccg tttgaaacca
     3841 tgaagtattg ttggaagata cggagcaatt caccttgacg gtcactatca tctgggtaaa
     3901 ggaagagagt caagttgcga gcgatatctg tcttgtcaaa gttgatacca tctttaataa
     3961 tagaagaatc aactgaatcc aagtcaaaca aacgcaagcg gtttttagtc gctgtttcat
     4021 aaccagtaac atcaatatcg taaagagttg atgtcaaagt aaagtctgca aatggtactt
     4081 ggtagctacg gcttgagcga accaaccagt tttgctctgt caaccatgca tttggaattg
     4141 tttcttgttg gttgttttta agaacttgtt ggaaaagacc aaagtggtag ttaagaccaa
     4201 caccgtcacc attcaaacca agagtagcaa ttgagtcgat aaagcaggca gccaaacgtc
     4261 ccaaaccacc attaccaaga gatggttcca attcaacttc ttcaacttcg atcaagtctt
     4321 tacctgcagc tgcaagttct tttttaacat cgtcgtaaag accaaggtta atcaagttgt
     4381 ttgacaagag tttaccaatc aagaactcag ctgagatgta gtaaactttt ttcttaccag
     4441 tgttgactgg tttttggctg cttgcaagct tgctgtagtt aagaagagca aggtaaagct
     4501 cttcattgct acattctgca atggttttat tgtaacgatt ttgtacaaat tcttgtagtg
     4561 ataacatgtt tagttgtctc ctgattattg tcttatttct ttaaatctac caaattttca
     4621 ttaattcggc gataaattgt tgtcaagtca agcaaacctt cctcgacagc tggtgtcaat
     4681 tgatcttcag tcatacgcca agaccagttt ccaccaaggg tagatgggaa gttcatacga
     4741 gctgcctcat ccaattctag taaatcttgc atagttgcaa ttgccataaa gctaactgat
     4801 gaaaatactg tacgaagcat agcgtgtacc actgtttcgt attctttacg gttcgtgtaa
     4861 cgagccatgt actcacgagt cgcatcatca atctcattac ggtaccaacc aagaaccgta
     4921 ttgttatcgt gtgttcctgt gtacataact gagttagcag gtgccaagtg tgggctatca
     4981 atgctttcgt cttctgggtt gaaggcaaat tgaagaatct tcattcctgg gaagccagta
     5041 cgttcacgca attcgatcac ttcatctgtc atgaagccaa ggtcttctgc gatgatgttt
     5101 agctcaccaa gttcttcctt aacggctgca aaaagcttgt agcctggacc tttcacccac
     5161 tcaccaggtg ctgctgtatc ggaaccagca gggatttccc agtaagattc gaagccacgg
     5221 aagtggtcga tacgaacgat atcgtagatt ttgaagcttt cacgcaagcg ttcaatccac
     5281 catttgtaac cgtctttgtc cattgcttcc cagtcataga ttgggttacc ccaaagctga
     5341 ccagttacag aaaactcatc tggtgggcat cctgcgatac aagtagcctt accattgaca
     5401 tctgttttga agagatgtgg atttgcccac atatcacttg aatcttccgc tacgtagatt
     5461 ggcatgtccc caacgatttc gatgtggttg tcgttagcgt aagctttcaa tttcaaccat
     5521 tgttggaaga agaagtattg agtcacacgg tggtaaacca acttgtctgc caattgctca
     5581 cgatagcttt caagtgctga agctttacga gcacgagcat ctgcatctgg ccattcagtc
     5641 caagcaagat tgtcaaaata ctctttgata gccatatact cagcaaagag ctcaagccat
     5701 gattggttgt cttgagcaaa tttctcaaaa tctttaacat ctccgacttc aaagaaacgt
     5761 ttcaccgctt tttctaaaag aggacgacgt gcatagtaga ttttagcata gtcaacttca
     5821 gacgcatcgc taccaaagtc aactccttca aggtcacttg cttccaacaa accttgctcc
     5881 accaagatat ctaaatcgat aaaatgagtg tttcctgcga aggctgagaa agattggtaa
     5941 ggagaatccc cgtaactagt tgctcctaat ggaaggattt gccagtaacg ttgttttgta
     6001 cggaccaaga aatcaacgaa gtcgtaagca ctttgaccaa atgatccgat tccgtaagct
     6061 cctggaagag aagagatgtg catcaacaca ccactttgac gttttttcat aatagcacct
     6121 cgtgtgttaa aataatggaa cgttgcgtat ttttcagacg caaacgtttg cgttacttat
     6181 aagtatactc cttttcaagc ataattgcaa gcgtttttaa aaaacttttt tgattatttt
     6241 taaggagact aactcatttt agcaaagata acttaaaact atctaatcct aaagtttgac
     6301 tctcacgaga cagtctacaa agtacaaaac ctccttaggg agcttgaatt tatatgcaat
     6361 aaagcacaaa cgtctataga aaatagatat agattagaaa cagggaggta gcccctcctg
     6421 atttccctct ttagacagat tccatatatt tttattaaaa atactgtatt cttatctatt
     6481 tcatactttt cttctattaa aatgcaaaat tatgctatca aatcaagctt aaaaattttt
     6541 taaaattttt acaaaaaata cttgcaaccg ttttctattt gtgctatact aagctcataa
     6601 aggaaaacgt ttgcgtttcc ttatcaataa aacttgctat tctttaggag gaatacacta
     6661 tgtcatctaa atttatgaag agcgctgcgg tgcttggaac tgctacactt gctagcttgc
     6721 tcttagtagc ttgcggaagc aaaactgctg ataagcctgc tgattctggt tcatctgaag
     6781 tcaaagaact cactgtatat gtagacgagg gatataagag ctatattgaa gaggttgcta
     6841 aagcttatga aaaagaagct ggagtaaaag tcactcttaa aactggtgat gctctaggag
     6901 gtcttgataa actttctctt gacaaccaat ctggtaatgt ccctgatgtt atgatggctc
     6961 catacgaccg tgtaggtagc cttggttctg acggacaact ttcagaagtg aaattgagcg
     7021 atggtgctaa aacagacgac acaactaaat ctcttgtaac agctgctaat ggtaaagttt
     7081 acggtgctcc tgccgttatc gagtcacttg ttatgtacta caacaaagac ttggtgaaag
     7141 atgctccaaa aacatttgct gacttggaaa accttgctaa agatagcaaa tacgcattcg
     7201 ctggtgaaga tggtaaaact actgccttcc tagctgactg gacaaacttc tactatacat
     7261 atggacttct tgccggtaac ggtgcttacg tctttggcca aaacggtaaa gacgctaaag
     7321 acatcggtct tgcaaacgac ggttctatcg taggtatcaa ctacgctaaa tcttggtacg
     7381 aaaaatggcc taaaggtatg caagatacag aaggtgctgg aaacttaatc caaactcaat
     7441 tccaagaagg taaaacagct gctatcatcg acggaccttg gaaagctcaa gcctttaaag
     7501 atgctaaagt aaactacgga gttgcaacta tcccaactct tccaaatgga aaagaatatg
     7561 ctgcattcgg tggtggtaaa gcttgggtca ttcctcaagc cgttaagaac cttgaagctt
     7621 ctcaaaaatt tgtagacttc cttgttgcaa ctgaacaaca aaaagtatta tatgataaga
     7681 ctaacgaaat cccagctaat actgaggctc gttcatacgc tgaaggtaaa aacgatgagt
     7741 tgacaacagc tgttatcaaa cagttcaaga acactcaacc actgccaaac atctctcaaa
     7801 tgtctgcagt ttgggatcca gcgaaaaata tgctctttga tgctgtaagt ggtcaaaaag
     7861 atgctaaaac agctgctaac gatgctgtaa cattgatcaa agaaacaatc aaacaaaaat
     7921 ttggtgaata aaaaatttgt tcaagggggg tggaaatcaa atcccccttt gaatttatca
     7981 atagagacac aaataattta gctttcttat aaaaaagtag tatcctatga aaggagttaa
     8041 tatggaaaag caacaaccta gtaaagcagc cctgctgtct atcattcctg ggttaggaca
     8101 gatttacaat aaacaaaaag ccaaaggttt tatcttcctt ggtgtaacca tcgtatttgt
     8161 cctttacttc ctagcacttg caacccctga attgagcaac ctcatcactc ttggtgacaa
     8221 accaggtcgt gataattccc tctttatgct gattcgtggt gccttccatc taatctttgt
     8281 aatcgtttat gtactctttt atttctcaaa tatcaaagat gcacatacga ttgcaaaacg
     8341 cattaacaat ggaattccag ttccacgcac actcaaagac atgatcaaag ggatttatga
     8401 aaatggcttc ccttacctct tgatcattcc atcttatgtt gccatgacct tcgcgattat
     8461 cttcccagtt atcgtaacct tgatgatcgc ctttaccaac tacgacttcc aacacttgcc
     8521 accaaacaag ttgttggact gggttggttt gaccaacttt acaaacattt ggagcttgag
     8581 taccttccgt tctgcctttg gttctgttct ttcttggact atcatttggg ctttggcagc
     8641 ttctacttta caaatcgtaa ttggtatctt cacagctatc attgccaacc aaccatttat
     8701 caaaggaaaa cgtatctttg gtgttatttt ccttcttcct tgggctgtcc cagccttcat
     8761 cactatcttg acattctcaa acatgtttaa cgatagtgtc ggtgctatca acactcaagt
     8821 attgccaatc ttggctaaat tccttccttt ccttgatgga gctcttattc cttggaaaac
     8881 agacccaact tggactaaga ttgccttgat tatgatgcaa ggttggctcg gattcccata
     8941 catctacgtt ttgactttgg gtatcttgca atctattcct aacgaccttt acgaagcagc
     9001 ttatattgac ggtgccaacg cttggcaaaa attccgcaac atcactttcc caatgatttt
     9061 ggctgttgcg gcacctactt tgattagcca atacaccttc aactttaaca acttctctat
     9121 catgtacctc ttcaatggtg gaggacctgg tagtgtcgga ggtggagctg gttcaaccga
     9181 tatcttgatc tcatggatct accgtttgac aacaggtaca tctcctcaat actcaatggc
     9241 ggcagctgtt accttgatta tctctatcat tgtcatctca atctctatga tcgcattcaa
     9301 gaaactacac gcatttgata tggaggacgt ctaagatgaa taactcaatt aaactcaaac
     9361 gtagactgac tcaaagcctt acttaccttt acctgattgg tctatcaatt gtaattatct
     9421 atccactgtt gattaccatt atgtcagcct ttaaagcagg taacgtctca gcctttaaac
     9481 tagatactaa tatcgacctc aattttgata actttaaagg cctcttcact gaaaccttgt
     9541 acggtacttg gtacctcaac actttgatta tcgccttaat taccatggct gttcaaacaa
     9601 gtatcatcgt acttgctggt tatgcttaca gccgttacaa cttcttggct cgtaaacaaa
     9661 gtttggtctt cttcttgatc atccaaatgg tgccaactat ggccgctttg acagccttct
     9721 tcgttatggc gcttatgttg aacgccctta accacaactg gttcctcatc ttcctctacg
     9781 ttggtggtgg tatcccgatg aatgcttggc tcatgaaagg ctacttcgat acagtgccaa
     9841 tgtctttaga cgaatctgca aaactagacg gtgcaggaca cttccgccgc ttctggcaaa
     9901 ttgttctacc acttgttcgc ccaatggttg ccgtacaagc tctctgggcc ttcatgggac
     9961 ctttcgggga ctacatcctc tctagtttct tgcttcgtga gaaagaatac tttactgttg
    10021 ccgtaggtct ccaaaccttc gttaacaatg cgaaaaactt gaagattgcc tacttctcag
    10081 caggtgctat cctcatcgcc cttccaatct gtattctctt cttcttccta caaaagaact
    10141 ttgtttcagg acttacaagt ggtggcgaca agggataatt tatccccgcc accctttttc
    10201 attttatact cttcgaaaat ctcttcaaac cacgtcagct ttatctccaa cctcaaagtt
    10261 gtgctttgag caacctgtgg ctagtttgca ctttgatttt cattgattat tagcaattgt
    10321 cactgtaaat aatatccttg tagcaagcaa tttttctcct agacttgaaa taaagcgcat
    10381 ttctctatat aataatactt atatagaaaa caccttttag aaagatacct atgcttccat
    10441 atccattttc ctttttttca agtattttgg ggtttcgtaa gcccctgtcc aaacgtttcg
    10501 ggctcaactg gtttcaactt ctctttacca gtatcttcct tatcagcttg tctatggtac
    10561 ccattgctat ccaaaacagc tcccaggaga cctatccgct agaaactttt atcgataatg
    10621 tctatgaacc tctgacaaat gaggttgtcc aggatctctc tgaacatgct acaattgtcg
    10681 atggcacatt aacttatact ggaacagtta gtcaagcctc ttctgttgtg attggtccaa
    10741 gtcaaatcaa ggaattacct aagaacttgc aactgcattt cgatacaaat gagctagtca
    10801 tcagcaagga aagcaaggaa ctgacccgca tctcttaccg agccattcag actgagagtt
    10861 tcaaaagcaa agacagcttg acccaagcaa tttctaaaga ctggtaccaa caaaatcgtg
    10921 tctatatcag cctcttccta gttctcggtg cgagcttcct ctttggtttg aatttcttta
    10981 tcgtctctct aggagctagt cttctccttt atatcactaa gaaatcacgc ctcttttcat
    11041 ttagaacctt taaagagtgc tatcacttta tcttgaactg tttaggattg ccgactctaa
    11101 ttacacttat tttgggatta tttggccaaa atatgacaac cttgattact gtacaaaata
    11161 ttctttttgt tctgtatctg gtcactatct tttataaaac acatttccgt gatccaaatt
    11221 accataaata ggagattttt atgcccgtta cgattaaaga cgtggccaag gctgctggtg
    11281 tttcgccttc aaccgtaacc cgtgttattc aaaataaatc aaccattagc gacgaaacaa
    11341 aaaaacgcgt tcgcaaggct atgaaggaac tcaactacca cccaaacctc aacgctcgta
    11401 gcttggtaag cagctatact caggttatcg gattagttct tcctgatgac tcagacgcct
    11461 tctaccagaa tcctttcttt ccatcggttc tacgtggcat ctctcaagtc gcatctgaaa
    11521 accactatgc cattcagata gcaacaggga aagatgagaa ggagcgtctc aacgctattt
    11581 cacaaatggt ctacggcaag cgtgtagatg ggctaatctt tctctatgcc caagaagaag
    11641 accctctcgt aaaactcgtc gcagaagaac agttcccctt ccttatctta ggtaaatctc
    11701 tatctccttt catcccactt gtcgacaacg acaatgttca agctggtttt gatgcgactg
    11761 aatatttcat caaaaaaggc tgcaaacgca ttgcctttat cggaggaagt aaaaagctct
    11821 tcgtgaccaa agaccgttta acaggctatg aacaggcgct taaacattac aaacttacca
    11881 ctgacaacaa tcgcatctac tttgccgacg agtttctgga agaaaagggc tataaattta
    11941 gcaagcgatt attcaagcac gatccacaaa ttgacgctat catcacaacc gatagcctcc
    12001 tagctgaagg tgtttgtaac tatattgcca aacaccagct ggatgtccct gttctcagct
    12061 ttgactcggt taatcccaag ctcaacttgg cagcctatgt cgatatcaat agtttagagc
    12121 ttggtcgtgt ttcccttgaa actattctcc agattattaa tgataataaa aacaataaac
    12181 aaatttgtta ccgtcaattg atcgcccaca aaattatcga aaaataagag actgggcaaa
    12241 gagtcgttaa aagcaaaaac gcatactatc aggtattgaa aaaacttgat actatgcgtt
    12301 ttattgtggg aagatttact tccttttcta ctgaaattga gtcttttccc aagatctttt
    12361 tatactcaat gaaaatcaaa gtgcaaacta ggaagctagc cgcaggttgc tcaaaacact
    12421 gttttgaggt tgtggataga actgacgaag tcagctcaaa acatggtttt gaggttgtag
    12481 atgaaactga cgaagtcagc tcaaaacatg gttttgaggt tgcagatgaa actgacgaag
    12541 tcagctcaaa acatggtttt gaggttgcag atagaactga cgaagtcagc tcaaaacatg
    12601 gttttgaggt tgcagataga actgacgaag tcagtaacat atatacggta aggcgacgct
    12661 gacgtggttt gaagagattt tcgaagacta ttaatcacta attatctatc tcaacaaatc
    12721 ttcctagaat atgaacattt tccgagacag agacaaagga gcttggatcc acttgtgtca
    12781 taatctgttt aaattcatta aactctgcac gtgtaatgac agtgattaaa actgcctttc
    12841 tctcgtgatt ataggttcct tctgcatcgt ggatcatggt tgctccgcgg tgcaattttt
    12901 tatggatttt ttcaattacc ttctctggat gatttgtcac aatcatggcc tgcatacgct
    12961 tttgcttagt aaagactgcg tctgtcacac ggctagagac aaagatggta atcatagaat
    13021 aaagagcgta tttccaacca aaggttaaac ctgctatcag catgatagtt ccatttacca
    13081 agaaagaaat actaccgaca ttcttacccg ttttcttgcg aatagtcagg ctgacgatat
    13141 ccgtcccacc actggagata ttgtttcgaa gagcaaaacc aatccccaaa cccataacaa
    13201 cacccccaaa aagggaattg ataatgggat cctccgtcaa ggttgccaca gggacaaact
    13261 ggataaagaa ggaactcata gataccgtga taaaggtaaa gacggtgaac ttatggccaa
    13321 tctgatacca agctaagacc atcaaaggga agttaatggc gtagaagctt agcgaaatcg
    13381 gaatatgaaa accaaaccag tgattactca aggcagagat aatctgtgcc agacctgttg
    13441 caccactcga atacacatgc cctggttgga aaaagaaatt aactgctact gctgataaaa
    13501 aaccatagac cagagaggcc gaaatcttct catcatactt ttctcgagag atactttgta
    13561 agacacgtaa aatttttatc tgataagcaa agcggcgcag ataatagcgc caccgcttaa
    13621 ttcgttttgt ttgtttcatc ttcttctact tgtaagctga gttcctctag ttgtttgaga
    13681 gcgactgttg atggagcttg tgtcattggg tcagttgcct tgttgttctt aggaaaggca
    13741 atgacttcac ggatattttc ttctccagca agcaacatga caaaacggtc aagcccgata
    13801 gccaaaccac cgtgtggtgg gaaaccatag tccatggctt caagaaggaa accaaactgg
    13861 tcattagctt cttcagctga gaaaccaaga gccttgaaca tgcgttcttg aaggtctttt
    13921 tggttgatac gaaggctacc accaccaagc tcataaccgt tcaagacgat atcgtaagca
    13981 atggcacgaa ccttagccaa atcaccttct aattcgtgag cagtctcttc ctgtggaaat
    14041 gtgaatggat ggtgggcgct catgtagcgg ccttcttctt cagaccattc aaacatcggc
    14101 cagtcaacca cccaaaggaa gttgaactta tcattatcaa tcaagccaag ctctttagca
    14161 atacgtccac gaagggcacc cagtgttgca ttagccactt caagcgtatc cgccacaaag
    14221 agaaccaagt ccttatcttc aagagcaagc gctgttgtca attcttcttg gataccagtc
    14281 aagaacttgg caactggtcc gtttaattct ccatcaacca ccttgaccca agcaagacct
    14341 ttggcaccat actgtttggc tacttccgtc atcttgtcga tgtctttacg tgaatagttg
    14401 tccgcagctc ctttgaccac aatcgctttt acagcaagtg cttctgaaaa gactttaaag
    14461 tctacacctt tgaccacttc tgtcaagtcc tgaagcaaca tgtcaaaacg agtatctggc
    14521 ttgtcagaac cgtaaagagc catagcatca tcgtatttca tacgagggaa cggtagcgtt
    14581 acttcgatgc cttttgtttc cttcatcacg cgcgcgatca agccttctgt aatatcttgg
    14641 atttcttgct cagtaaggaa ggacgtttcc aagtcgacct gagtaaattc aggctggcgg
    14701 tctccacgca agtcctcgtc acggaaacat ttaacgattt ggtagtaacg gtcaaaacca
    14761 gcattcatca agagctgttt cgtgatttgt ggactttgag gaagagcgta aaaatgcccc
    14821 ttattaacac gagacggcac taaataatca cgcgcccctt caggcgttga cttagaaagg
    14881 aatggtgtct ccacgtcgat aaactccaac tcatccaagt agttgcggat agagtgggtc
    14941 accttggcac gaagtttaag attttccaac atttctggac gacgaaggtc aaggtaacgg
    15001 taacgcaaac gtgtatcgtc atttgcctca atgccatcct taatctcaaa tggtgttgtc
    15061 ttagctgtgt taagcacaat aagagctgtc acgtttaact caaccgcacc agttggcaac
    15121 ttatcattgg cttgctcacg cgcagcgacc tgaccagtca cctcaataac aaattcgcta
    15181 cgaaggcttt cagctgttgc cataacctct gcagatactt tttcagggtt gataaccaac
    15241 tgcatgattc cttcacggtc acgaagatcg ataaagatca aaccaccaag gtcacgacga
    15301 cggccaaccc atcctttcaa ggttatttct tgtccgatgt gttcctcacg aacacgacca
    15361 gcatacatac tacgtttcat tatttctctc ctcttttatt ctgttactat tttaccataa
    15421 aagcgcaggc tcttcatgaa aatcatcaga aaagtttgcc agtctttaaa agtcaggtga
    15481 aagccctaaa aattagcgct aatactcttc gaaaatctct tcaaaccacg tcagcgtcgc
    15541 cttaccgtag gtatggttac tgacttcgtc agtttcatct acaacctcaa aaccatgttt
    15601 tgagctgact tcgtcagttt catccacaac ctcaaaacag tgttttgagc aacctgcggc
    15661 tagcttccta gtttgctctt tgattttcat tgagtattac ttcactgccc cgttgcttat
    15721 tcctgcgatg atatggcgtt ggaagaagag atagacaatg gtgatactga taatgccgac
    15781 cacgtaagag gcaaagcttg gtccgtagtc gttgaaatat tggcctgcgt agttgtattg
    15841 gaacaaaggc agagtccaca ttttggaatc ccggttcaag acaaggagtg gcaacatgaa
    15901 gtcattccag aaccaaaggg cattgatgat catggttgtc gcatgcatcg gtttcatcat
    15961 tgggaagatg atgcggaaat aggttgtaaa ttgattagcc ccatcgatct ctgctgcttc
    16021 atccagactt tctggaatcg agattttgat atagccaaca tagagaaaga gggtctgtgg
    16081 aatcgcatag gtcaagtaga gcaagatcaa accaaaggta ttagccaaac cgagtttact
    16141 catcataacc gtaatcggaa tcatgatgac ttggaaaggt acgaatattc cgaggattaa
    16201 gagggtatac atgatggtaa aggcttttct tttactcata ttgcgagcga tggagtaggc
    16261 tgccataggg ataaagatca ttactgcaag taaagacaag acagtgatga cgacagagtt
    16321 ccaataatag cctccaatcc catcagctaa gagacggcta aagttgtccc atgtgaagtt
    16381 ggttggaaag ccaaagaaat tatctacaat atccttagtg ggtttgaagg aactaaagag
    16441 ggtagcaagg agcggcacta aaatcagaac cgatcctaga accaatagaa tgtatttgcc
    16501 aatcagggct tttctttcat cttgtttcat catgcttctc ctcttaaatt tcaaatttct
    16561 tagatactct caattggatg atcgaaatca ctacaattaa gaggaacaag attacggcaa
    16621 tggcattggc ataaccgaat tggttgtttt taaaggcata gttataaacc aagagcccaa
    16681 gtgaggttgt ggcattgttt ggaccaccac cggtcatggc aaagacttgg tcaaaggcag
    16741 tcagcccacc ttttagggct aggataaaga ccatagagac acttggtagc aagtaaggca
    16801 attcaatgtt ccagaaaact tgcttgctag tcgcaccatc aatccttgct gcctctgtaa
    16861 tctcagttgg aatagattgc aaaccagcta ggaagatgat gatgggcata gccacccctt
    16921 gccaaagaag gacaaaggca gccgcaaaga ttgctcccca cttagtccct aaaagactgg
    16981 tttggagaaa ttcaatatga agggcattcc caatcgctgg aagaccgtag ttgaagactt
    17041 gcttgaagat caaagccact gtcaaaccag ataaaacagc tgggaagaag aaccaagcac
    17101 ggaagaaggt ttggcctttg attttagaat tcaagacacg cgcaatgaag atcccgagtg
    17161 caatctcacc aaccaccatg gcaatcgtaa tgattgcggt aaagccaatc gcattcatga
    17221 attttggatc catgaagagg agcttaaagt tgtttaagcc aacaaatttg tagttataag
    17281 tcaatcctgt ccagttggta aaactgtaaa aggctccttg aaacatcggc acatagaaga
    17341 aaattgcttg taacaagagg gggatgacca caaaagccca tgcccaatat ttttgtaata
    17401 cttttttcat agtctctcta ctcctaatcc acatccgctt tcatcgggtt aaagaaggca
    17461 ttcaaatcat tgaccatgcc ttgtttatca ccggtcaaga catagttcat ggtcaaggta
    17521 tggaagtctg cttcactggt ccagtattgt tgcaaccaga ccaagtgacg atccgtaaag
    17581 gcatattcgg tcataccagc aagcggtgaa tcttctcctg cttgtttgac cccttcgatc
    17641 gctgttggag atccgtccac atcgtagtat ttttgcatga cttctggacg ggtcatatat
    17701 tccacaaagg cattggcttc ttttggatgt ttggtggtgg ctgagataga ccatgccaag
    17761 tctcccgcac caacggttaa gctttgtcct ttttcttttc ctggaatcat gaaggtccca
    17821 atcttaaagt tcggtttttg ttcattaatc gctgtgatcg cccaagaccc atttggtgtc
    17881 atgaggacat ccccacgtgc gaaggctccg ataacatcgg tatagccagc accttcccag
    17941 ttcttttgct tagagccatt gatgcgaagg atgtccatga ccttgatatc atctttcata
    18001 atcggatccg acaatttaat ggcatttggt tgagaataac gaaggtattg atttgcttct
    18061 tttcctccac ctgttgctgt cgcaaaggct aattgattgt aaccattgag tgtccaagca
    18121 tctgcacctg caattccaaa tggtgtttgt cctttagcaa cgatatcttt gactaactgt
    18181 tcaaattcat cccaggtttc aggaaccttc aagcccagtt cttcgaattt atctttgttg
    18241 tagtaaattc cataagcatt agctgtaaaa ggaacgttgt aaactttttc gtttacagca
    18301 tatttttcag cgtagccatt tttcacgcgt ttcaggtagt ctttgttgct caaatcttca
    18361 aagacacctg cttttgccca ttcttgcagt tcgatggact gtgggtaaat attgaccaca
    18421 tcaggcacat ctcctgcgag aacgcgtgtc ttcaatactt caccagcatt tggtacattg
    18481 acgactttga ccttgatctt agggttttcc ttctcaaaat cacgagtgat ttcttccaag
    18541 gttttggtca tttctttttt ctggttgaaa tactcgatgg tcactgtgcc atccgcagat
    18601 ttaccatagt tggagcaagc gccgagccca accaaagcta aacctgtagt tacaagaagt
    18661 ccgatttttt tataccattc cattagaaag cctcctttat aaatttatac acccttattg
    18721 aactgcaccc caaaagttag acagaataaa tctaactttt ggggtcagta catatcatag
    18781 ttttctaaaa atatactgtc tactcaaaaa atctccttgg gataagataa cagttaagcc
    18841 cgcatacatt agttctgcac ctgagtaaac ttcgccattt tcctgtaatt tatatagtcc
    18901 ctcttcatcc aaatctttta attttaaagt tgtttccatg gtctctacaa cagataaaac
    18961 gcgaacgtag gttacaatcg tttgatttcc gtaattaaat tgtacagctg cttcattgga
    19021 tgcagtatca ggattaatta gtctatactg ctgtcctaac tgaactactg gtcgtaattc
    19081 tttatacaag ttcacctgat tagcaatcgt agctttctct tcatctgata aatttgtcaa
    19141 atcaagctca tagcccaaat ttcccatcat tgctacatgg ccacgtgttt ctaatggtgt
    19201 cattcgtccc atctgatgat tcggtactgc tgacacatga gcccccatag aaatggttgg
    19261 atagagatag gatgaaccgt attgaattgg taaacgtgca atggcatcag tattatcact
    19321 agcccagact tgtgggaaat agcgtatcat accaagatca tttcgtccac caccaccaga
    19381 gcaggactca aagagaatat ggctgtgctt ctctgtcaga taagaaacga gttcgtaaag
    19441 ccccagcatg tactgatgag attgcatctg tgtctctaga taagttaatc cattccctag
    19501 cttagtgata ttgcggttca tatcccattt aatgtaatca atctcatgat aagataggag
    19561 ttgatctaag acacttttca agtattctac tacctgagga ttggcaagat taagtactaa
    19621 ttgattccga gaataagtat gctcataatc aggaacctga atagcccagt caggatgttg
    19681 acgatacaaa tcactatcta cagaaatcat ttcgggttct aaccaaagtc caaactgcaa
    19741 acctctttca tggatagctg aaatcagact ttctagactt ccacccagtt tttcctcatt
    19801 aacaacccaa tcacctaaag cacgattatc atcaaaacga ttgccaaacc aaccatcatc
    19861 taatacaaaa agttcaatgc caactttctt agcttcatct gctaactcta acagtttttc
    19921 tctctgaaag tcaaagtaag tagcttccca gttattgatt agaattggac gttctttttt
    19981 agaaaattca cttagaataa tgtgcttcag tacaaaattc tgactttcat gactaatacc
    20041 agttaatccc tgatctgaat gagtcactaa agctaccggt gtttcaaagt attcctcagg
    20101 ggctaacttc caagaaaagt tttctggatt aatgccaata gccacccgaa cttcattcaa
    20161 ttgatttttt tgaacaaaag cttcaaagtt gccactatac attagttgaa tagcaaacac
    20221 attcccagca tcctctgtga ctccttgttc gcatagtaga agagctggtg tttgagcatg
    20281 accagaagca cctcggtttg agctaatcga aaagattcct tgttctacct gttgacgtct
    20341 aacagtcttt tcacgagcat aagcaccctg cagagttact atttcgtaat ctgcagctgg
    20401 aaaatcagcc ataaaagaaa aatctttatg gatgacaact tcctgattac tattattatc
    20461 taatttactg tagctagcaa tagtcgcatc attattaaaa gtagtataat acaaagtcag
    20521 actaagttga gccttagaat cttctaacat taagacaaga gtctctgtat cgtccatgct
    20581 atgtggagaa ggtaagccct gtggaccatt ctgacctttt aaaatctttg cttctacaaa
    20641 tcgaaagtct gttacttcag ttacactatg ctgaacctgt atggttggtt tcctaaaatc
    20701 tcctaagcca tgttgtccaa aaatctgtcg ctgagtatct aaactaaagg ttcgattagt
    20761 agccgttgga tttcctgaaa aggcatggtc tcgttcataa acactattgg aacctttata
    20821 gttcttaata gtctttccta aatgtttcaa aagtaagtag ccatttcgat tttcaataat
    20881 caaacttaga tttttactct caacataaaa tagattattc tctatcctaa ctcccattta
    20941 cttcacctca tcactttatt gattatattt tatcacctga aatcgctttc taaaatagaa
    21001 aaatgtctca agaatatggt aaaatgttag gtaggaggta gcacatgtta gttttttcag
    21061 aataccagac tggaacaatc gaccttgccc taagctttta tggatatgag gaatgcacac
    21121 ctaattactc ttttggtcca gccattcgtg atacatacgt cctacattac attactaaag
    21181 gacaaggaaa atttcattac aagggtaaaa ttgttaattt aaaagaagga gatttctttc
    21241 tattaaaacc agaggaacta accttttatc aagcagatag taaagaacct tgggcctact
    21301 actggttagg aatcactgga gggaaatccc ctgattattt tgctctttct caaatttctg
    21361 atcaatccta tctcatccaa tctgaaactt gtcataccca gactactgca aaactcatct
    21421 cagacattgt ccgcttcgct cagattacaa aatcaagtga attagctcaa ctccatatca
    21481 tgggacaact tcatgaactg atgtttcatc tgggaactat tgctcccaat cagaaaaaaa
    21541 agaatatttc atcaacccac caactctatc ttgaatgcaa acgattaatt gatagccact
    21601 atcctcaatc acttacaatt caagatttag caaaagaact atccgttcac agaagctact
    21661 tatcaagcgt attcaaagaa tttaatacct tatcacccaa agaataccta ctctacgttc
    21721 gaatgcaccg agctagacaa cttctcgaaa atacccaaga gtccatcaag gtaattgcat
    21781 actcggtagg tttttcagat ccactccatt tttcgaaagc ttataaacaa tactttaatc
    21841 agactccaag tcatacaaga aaagaatact ctcaatacca actagtgaga aaggcaacat
    21901 tatgaaatcc taccaagctg tctaccaaat cctatctaaa gaaaccgact atatcagcgg
    21961 agaaaaaatc gcagaaaaac tatccctaag ccgaacatca atttggaaag ctatcaagcg
    22021 actagaacaa gaaggcattg aaattgatag tatcaaaaat agaggatata aactaatgaa
    22081 tggtgacctt attcttccag agattctaga agaaaatctt ccaattaaag tcagctttaa
    22141 acccgaaaca aaatcaacac aactagatgc aaaagaagca attgatttag gccatgaagc
    22201 aaataccctc tatctagctt cctatcaaac agcaggccga ggccgttttc aacgttcctt
    22261 ctactcacca caaggtggta tttatatgac actccatctt aaaccaaatc tcccctatga
    22321 caaattacca tcctacacac tacttgtagc tggagctgtc tacaaagcca ttaagaacct
    22381 aactttaata gatgtcgaca taaaatgggt caatgatatc tatctaaaca atcataaaat
    22441 tggaggaatc cttactgaag caatgacctc tgtagaaact ggcttagtca cagatatcat
    22501 tattggagta ggtatcaatt tcactattaa agacttccct caggaattaa aagcaaaagc
    22561 tgccagctta tttaaagcta cagctcctat aacaaggaat gaattgatca tagaaatctg
    22621 gcgtgctttc ttcgaaacac cagcagaaga gctattatac ctatacaaaa aacagtcatt
    22681 cattctagga aaagaagtca ctttcacact agagcaaaaa gactacaagg gacttgctaa
    22741 agacatctca gaaaatggaa aacttttaat tcaatgtgat aacggaaaag aaatctggct
    22801 aaatagtggc gaaatttctc tcaatagttg gaagtaaaat aacacaatta taatataaac
    22861 gatataaaaa taacttcaga ttagtaattc aattaagttt tacggatctg aagctttatt
    22921 gtctctaaaa ataaaaaaga gagttacaaa ctctcattaa aacggagaat aagggattcg
    22981 aacccttgcg ccagttaccc gacctaacga tttagcaaac cgtcctcttc agcctcttga
    23041 gtaattctcc aatt
//
LOCUS       DBERMM010000028        22902 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.028, whole genome shotgun sequence.
ACCESSION   DBERMM010000028 DBERMM010000000
VERSION     DBERMM010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 22902)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22902)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22902
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.028"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(319..483)
                     /locus_tag="ACL8AS_001393"
     CDS             complement(319..483)
                     /locus_tag="ACL8AS_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229238.1"
                     /translation="MKKKILIIFILYLIMSIFLYPLRESIWYQLFYTIAYVIAVMIYF
                     ALTKKKGAKK"
     gene            complement(1057..1260)
                     /locus_tag="ACL8AS_001394"
     CDS             complement(1057..1260)
                     /locus_tag="ACL8AS_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pncT"
                     /protein_id="HGS1229239.1"
                     /translation="MEKIDYITLNEVELETISGGDDCFIGDIGCIGWGLLKSIGGMIK
                     PAPYVPPVCIPKSSWNPAPPVPC"
     gene            complement(1578..1781)
                     /locus_tag="ACL8AS_001395"
     CDS             complement(1578..1781)
                     /locus_tag="ACL8AS_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin class II family protein"
                     /protein_id="HGS1229240.1"
                     /translation="MNTKMMSQFSVMDNEMLDRIEGGIFGVDDALFWAGLGYVAGSIV
                     DTAIDDFTNQCRKNPHQWFCVRV"
     gene            2062..4215
                     /gene="blpA"
                     /locus_tag="ACL8AS_001396"
     CDS             2062..4215
                     /gene="blpA"
                     /locus_tag="ACL8AS_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_125458604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter BlpA"
                     /protein_id="HGS1229241.1"
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKT
                     NKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQ
                     TKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
                     IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYIL
                     QQVMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDANSII
                     DALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMFIIFSFMKPFEKMNH
                     DVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQT
                     SLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQS
                     AKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDTLTDINLTIK
                     QGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHINYLPQQ
                     AYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGG
                     QKQRIALARALLTKSPVLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAE
                     RTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK"
     gene            4226..5587
                     /locus_tag="ACL8AS_001397"
     CDS             4226..5587
                     /locus_tag="ACL8AS_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="HGS1229242.1"
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKE
                     ITVTSQGEIAPTSVIASIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTAL
                     ATQLQRLEKQKEGLGILKQSLEKATDLFSGEDEFGYHNTFMNFTKQSHDIELGITKTN
                     TEVSNQANLSNSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTGNPHQSILNRY
                     LVASQGQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVL
                     RTQFLQTASQQQLTVENQLTELKVQLDQATQRLENNTLTSPSKGIVHLNSEFEGKNRI
                     PTGTEIAQIFPVITDTREVLITYYVSSDYLPLLDKGQTVRLKLEKIGNHGTTIIGQLQ
                     TIDQTPTRTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTTKKTYFDYFKDKILT
                     HSD"
     gene            5644..5772
                     /gene="blpC"
                     /locus_tag="ACL8AS_001398"
     CDS             5644..5772
                     /gene="blpC"
                     /locus_tag="ACL8AS_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="HGS1229243.1"
                     /translation="MDKKQNLTSFQELTTTELNQITGGGLWEDLLYNINRYAHYIT"
     gene            complement(5843..7183)
                     /locus_tag="ACL8AS_001399"
     CDS             complement(5843..7183)
                     /locus_tag="ACL8AS_001399"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HGS1229244.1"
                     /translation="MNIAWILLYTLVTNGLEIVIFFKVDGIDLAFERIFKAFLFKILL
                     AFVFVMISYIVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRG
                     VSYFVLPFLGQGQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRKEILDKAFQK
                     SLTQINWIMGGYYLVMESLSFFEYEQSIQSKTVRHLILVFYLLFFMGVIKKLDTYLKE
                     KLYERLEQEQALRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIK
                     EVYGSVLKDSSQKLQNNKYDLGRLVNIRDKALKSLLAGKFLKARDKNIVFNVEVPEEI
                     QVEGMSLLDFLTIVSILCDNAIEASVEASQPHVSIAFLKNGAQETFIIENSIKEEGID
                     ISEIFSFGASSKGEERGVGLYTVMKIVESHPNTSLNTTCQNQVFRQVLTVIHTE"
     gene            complement(7197..7934)
                     /locus_tag="ACL8AS_001400"
     CDS             complement(7197..7934)
                     /locus_tag="ACL8AS_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HGS1229245.1"
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLL
                     AEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFMPLSFRYQ
                     VSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
                     LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKL
                     LFFPNGGSCLIARYKVREVSEAINKLH"
     gene            complement(7939..8277)
                     /locus_tag="ACL8AS_001401"
     CDS             complement(7939..8277)
                     /locus_tag="ACL8AS_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="HGS1229246.1"
                     /translation="MKYMIIQTQKTVYKVNIDDIYYIQTHPTKAHTVQIVTEEASFNM
                     LQNLSNLENQCGETLMRCHRNCLVNLDKLKSIDFQERILFLGEEGQYAVKYARRRYRE
                     IRQKWLKEGE"
     gene            8554..8883
                     /locus_tag="ACL8AS_001402"
     CDS             8554..8883
                     /locus_tag="ACL8AS_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HGS1229247.1"
                     /translation="MTDTDPIKRAHTLITDLNKAYQACKQASADDVRFQEQLNSILGF
                     LAKAETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLIL
                     NENQRAN"
     gene            complement(9051..10100)
                     /locus_tag="ACL8AS_001403"
     CDS             complement(9051..10100)
                     /locus_tag="ACL8AS_001403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229248.1"
                     /translation="MKDLFLKRKQAFRKECLGYLRYVLNDHFVLFLLVLLGFLAYQYS
                     QLLQHFPENHWPILLFVGITSVLLLLWGGIATYMEAPDKLFLLVGEEEIKLHLKRQTG
                     ISLVFWLFVQTLFLLLFAPLFLAMGYGLPVFLLYVLLLGVGKYFHFRQKASKFFTETG
                     LDWDYVISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKAVQKVPGKIWQNL
                     YLRSYLRNGDLFALSLRLLLLSVLAQVFIEQAWIATAVVVLFNYLLLFQLLALYHAFD
                     YQYLTQLFPLDKGQKEKGLQEVVRGLTSFVLLVELVVGLITFQEKLALLALLGAGLVL
                     LVLYLPYQVKRQMQD"
     gene            complement(10097..10828)
                     /locus_tag="ACL8AS_001404"
     CDS             complement(10097..10828)
                     /locus_tag="ACL8AS_001404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229249.1"
                     /translation="MLEIKNLTGGYVHVPVLKDVSFTVESGQLVGLIGLNGAGKSTTI
                     NEIIGLLTPYSGSININGLTLQEDATSYRKQIGYIPETPSLYEELTLREHIETVAMAY
                     GIEQKVTFERVEPLLKMFRLEQKLDWFPVHFSKGMKQKVMIICAFVVDPSLFIVDEPF
                     LGLDPLAISDLIQLLEVEKQKGKSILMSTHVLDSAEKMCDAFVILHKGEVRAKGNLLQ
                     LREAFDMPEASLNDIYLALTKEEDL"
     gene            10896..11306
                     /locus_tag="ACL8AS_001405"
     CDS             10896..11306
                     /locus_tag="ACL8AS_001405"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HGS1229250.1"
                     /translation="MSDCIFCKIIAGEIPASKVYEDEQVLAFLDISQVTLGHTLVVPK
                     EHYRNLLEMDATSASQLFAQVPKVAQKVMKVTKAAGMNIISNCEEVAGQTVFHTHVHL
                     VPRYSADDDLKIDFIAHEPDFDKLAQVAETIKNA"
     gene            11316..11603
                     /locus_tag="ACL8AS_001406"
     CDS             11316..11603
                     /locus_tag="ACL8AS_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229251.1"
                     /translation="MKLSNLLLFAGAAAGSYLVTKNRQTITDEVLNTTDRVQAIKDDV
                     DIIQNSLQIIDQQKELIKEYQEDLTYKFKVLEKDIQTRLAVIKEMQGTEDK"
     gene            complement(11970..13106)
                     /gene="dnaJ"
                     /locus_tag="ACL8AS_001407"
     CDS             complement(11970..13106)
                     /gene="dnaJ"
                     /locus_tag="ACL8AS_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HGS1229252.1"
                     /translation="MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAED
                     KYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGAGGFGGFNGAGGFGGFEDIFSSF
                     FGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
                     SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAH
                     SVHVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLN
                     LNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVN
                     VVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE"
     gene            complement(13321..13725)
                     /locus_tag="ACL8AS_001408"
     CDS             complement(13321..13725)
                     /locus_tag="ACL8AS_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanine-N7)-methyltransferase"
                     /protein_id="HGS1229253.1"
                     /translation="MDEEYLKNTRKVYNDFCNQADNYRTSKDFIDNIPIEYLARYREI
                     ILAEHDSCIKNDEAVRNFVTSVLLSAFVSALVSAMISLEIQTYKFVIPFIIGMIWTVV
                     VFLMINWNYIANTKKRQKYINISVLIGYLKSK"
     gene            complement(13736..15559)
                     /gene="dnaK"
                     /locus_tag="ACL8AS_001409"
     CDS             complement(13736..15559)
                     /gene="dnaK"
                     /locus_tag="ACL8AS_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HGS1229254.1"
                     /translation="MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKN
                     GEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAE
                     DYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDK
                     EEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKEN
                     GIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFD
                     DLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKS
                     VNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK
                     SQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
                     NGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNE
                     VDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQ
                     GLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK"
     gene            complement(16039..16563)
                     /gene="grpE"
                     /locus_tag="ACL8AS_001410"
     CDS             complement(16039..16563)
                     /gene="grpE"
                     /locus_tag="ACL8AS_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000046028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HGS1229255.1"
                     /translation="MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFEN
                     KYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKG
                     LGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKL
                     HDRILRPAMVVVYN"
     gene            complement(16590..17624)
                     /gene="hrcA"
                     /locus_tag="ACL8AS_001411"
     CDS             complement(16590..17624)
                     /gene="hrcA"
                     /locus_tag="ACL8AS_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcriptional repressor HrcA"
                     /protein_id="HGS1229256.1"
                     /translation="MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDM
                     AELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLE
                     DILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
                     FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFE
                     HIFKEMFNENIVMAGKVHLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADG
                     QESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQVNVVNRVLTMKLTDFYR
                     YLSSNHYEVH"
     gene            complement(17788..18297)
                     /locus_tag="ACL8AS_001412"
                     /pseudo
     CDS             complement(17788..18297)
                     /locus_tag="ACL8AS_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001088691.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
     gene            18904..21237
                     /gene="hsdR"
                     /locus_tag="ACL8AS_001413"
     CDS             18904..21237
                     /gene="hsdR"
                     /locus_tag="ACL8AS_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0015666 - restriction
                     endodeoxyribonuclease activity [Evidence IEA];
                     GO_process: GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="EcoAI/FtnUII family type I restriction enzme
                     subunit R"
                     /protein_id="HGS1229257.1"
                     /translation="MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTD
                     GRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDV
                     PFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY
                     TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLA
                     KRVLFLADRNILVDQTMAEDFRPFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGE
                     DGTETHYQKFDKDFFDLIVIDEAHRGSAKEDSNWRKVIDYFSSATQIGMTATPKETKN
                     ASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIED
                     RYYGRKDFDKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVK
                     ENLDLVQEDYRYVMQVTGDNAEGKAQLDNFMDVNSNFPAIVTTSKLLTTGVNAKTCRL
                     IVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGDPVKVLE
                     TGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRK
                     NILGSYATLNDFITVWHTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLK
                     LAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILLNKYMDKGIGELESIETLKLP
                     EFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA"
     gene            21250..22713
                     /locus_tag="ACL8AS_001414"
     CDS             21250..22713
                     /locus_tag="ACL8AS_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HGS1229258.1"
                     /translation="MSITSFVKRIQDITRNDAGVNGDAQRIEQMSWLLFLKIYDSREM
                     VWELEEDEYESIIPEELKWRNWAHAQNGERVLTGDELLDFVNNKLFKELKELEITSNM
                     PIRKTIVKSAFEDANNYMKNGVLLRQVINVIDEVDFNSPEDRHSFNDIYEKILKDIQN
                     AGNSGEFYTPRAATDFIAEVLNPKLGESMADLACGTGGFLTSTLNRLSSQRKTSEDTK
                     KYNTAVFGIEKKAFPHLLAVTNLFLHEIDDPKIVHGNTLEKNVREYTDDEKFDIIMMN
                     PPFGGSELETIKNNFPAELRSSETADLFMAVIMYRLKENGRVGVILPDGFLFGEGVKT
                     RLKQKLVDEFNLHTIIRLPHSVFAPYTGIHTNILFFDKTKKTEETWFYRLDMPDGYKN
                     FSKTKPMKSEHFNPVRDWWENREEILEGKFYKSKSFTPSELAELNYNLDQCGFPKEEE
                     EILDPFELIQNYQAERATLNHKIDNVLADILQLLEDK"
     gene            22713..>22902
                     /locus_tag="ACL8AS_001415"
     CDS             22713..>22902
                     /locus_tag="ACL8AS_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction endonuclease"
                     /protein_id="HGS1229259.1"
                     /translation="MTPEQLKASILQRAMEGKLVPQNPNDEPASELLKRIKAEKEKLI
                     SEGKIKRDKKETEIFRGDD"
BASE COUNT         7331 a         4613 c         4136 g         6822 t
ORIGIN      
        1 aacaagacgc ttaaatcgtg catcagttag ttgtttactt gcttcatcat tcatagaact
       61 atagtaaaat gaaataagaa caggataaat cgatcaagac agtcaaatcg atttctaaca
      121 atgttttaga agtagagacg tactattcta gtttcaatct actatactat accatatttt
      181 gtttcgcagg gaatctatta taaaagggta agtatttcaa aaacacttac ccctttatac
      241 tttattaagc tctacttttt ataatacttc aatccccaaa tgaaaggaag atgttccgtt
      301 ttttagcaag aaaagttttc atttctttgc tcctttcttt ttagttaaag caaaatagat
      361 cataactgca atcacatagg ctatggtata aaatagctga taccaaatac tttccctaag
      421 cggataaaga aagatggaca tgattagata caagatgaaa atgataagta tttttttctt
      481 cataaaattt cctcctaaat gtgtgattta tcttagttga acaagaatct ttacactgct
      541 agtatagcac tcattttgac cttggattac tcaaatcatg aatggtcatc aaaacatctt
      601 gaacaataac aagattttca tctatacaaa aatagttata ctcaacaaca atcaaactaa
      661 agaaccaaat aaatatagct taacatactt tttttggatt tcaaacaata ctgataaaat
      721 taataataaa tctgtggtag tacttcccat ccctactgct ttccaatttt ataatattat
      781 taattaaata atatatgaga aaaaacgaac aagactgtgt taataatcta tcttattcgt
      841 tttatttatt agacttgttc agaaattatt tgaagcagta ttagctggtt agaaagtgaa
      901 tttttaacgt tccaaccagc cattagtttc tagttttcga ctcttgcaat aagctaaaat
      961 aatcctgaac aacacctgta tattataatt gcgaagattc aacaaaatag cgaacaagtc
     1021 gattattcat tttttatata agtttacaat aactttttaa catggaactg gaggtgcagg
     1081 attccacgaa ctttttggaa tgcatactgg aggaacatat ggagcaggtt ttatcatccc
     1141 tccgatactc ttcaaaagcc cccagccgat acatccgata tctccaataa aacagtcatc
     1201 tccaccacta atcgtctcta attctacttc attcaaagta atataatcaa ttttttccat
     1261 tgttataatt cattcctttc gttttactca aggcacaaca cagaatgaaa aagtgttgta
     1321 ctctttattt tataatgttt ataataatag tgagaaaacc tatcactact acaaatcacg
     1381 gggaggtgaa taagtgagtg atatagccaa tatctcgcat ttttataggt gtcattcttt
     1441 ctatcaagca caagaactgt gactaggagc acgtaaactt ataacagaat aagcgactcg
     1501 tttgcaaaag aatagtttct atcactgcat aggtcattaa gttatataaa ttcttataca
     1561 atacaacact actatatcta tacacgaaca cagaaccact gatgaggatt tttccggcat
     1621 tgattcgtaa aatcatcaat tgctgtatca acaatgctac ctgcaacata gcctaaccct
     1681 gcccaaaaca aagcatcgtc aactccaaat attcctccct ctatcctatc aagcatttca
     1741 ttatccataa cagaaaattg tgacatcatt tttgtattca tgacaaatac tcctttttta
     1801 tttttaattt ttgtcttgtt gcaactttga caagtttagt atatcattat tttttaattt
     1861 ttttcatcca aatcttgaat tgccatcgaa acgtcttgaa ttagcttttt tatttcaagc
     1921 cacctctaaa tgtttaaaaa aaataatttc taatcacttt tttaccattc aggaagtttt
     1981 aatgactatt caagatttca taaaatatga acttagtttt atggcataat atacctatcc
     2041 actatatgaa aggaattgcc aatgacttct tataaacgta catttgttcc tcaaatagat
     2101 gcgagagact gtggtgtcgc tgccttagcc tcgattgcta aattctatgg ttcagatttt
     2161 tctctagctc acttgagaga acttgcaaag accaataaag aagggacgac tgctcttggc
     2221 attgtaaaag ccgctgatga aatgggcttt gaaacaaggc ctgttcaagc agataaaact
     2281 ctctttgaca tgagtgatgt cccctatcca tttatcgttc acgttaacaa agaaggaaaa
     2341 ctccaacatt actatgttgt ctatcaaaca aagaaagact atctggttat tggtgatcct
     2401 gacccttctg taaaaatcac taaaatgtca aaagaacgct ttttctctga atggactgga
     2461 gtagctattt ttctagctcc caaacccagc tatcaacccc ataaagataa aaagaatggt
     2521 ctactaagct tccttcctct gattttcaaa caaaaatctc tcattgctta cattgttctc
     2581 tcaagcttat tggtcactat tatcaatata ggtggttctt attatctcca aggaatctta
     2641 gatgaataca tcccaaatca gatgaaatca actttaggaa tcatctcagt tggtctggtt
     2701 atcacctata tcctccaaca agtcatgagc ttctccagag attatctcct aaccgttctg
     2761 agccagagat taagcattga tgtgatttta tcctatattc gccatatttt tgaacttccc
     2821 atgtctttct ttgcgacacg tcgtacagga gaaatcattt cacggttcac agatgctaac
     2881 tctattatag atgccttggc ttctaccatt ctttctcttt tcctggatgt ttctattctg
     2941 attcttgtag ggggcgtctt actggcacaa aaccctaatc tcttccttct ttctcttatt
     3001 tctattccta tatacatgtt catcatcttt tcttttatga agcctttcga aaaaatgaac
     3061 catgatgtca tgcaaagtaa ttctatggtt agctctgcca ttatcgaaga tatcaacggg
     3121 attgaaacta taaagtcgct cacgagtgaa gaaaatcgct atcaaaatat agacagcgaa
     3181 tttgtagatt atttggaaaa atcctttaag ctcagtaaat attctatttt acaaacaagt
     3241 ttaaagcagg gaacaaaatt agttctgaat atccttatcc tatggtttgg cgctcaatta
     3301 gtcatgtcga gtaaaatttc tatcggtcag ctgattacct ttaacacact tttttcttac
     3361 tttacaactc ctatggaaaa tattatcaac ctccaaacca aactccaatc tgcgaaggtt
     3421 gctaataacc gtttgaacga agtctatcta gtcgaatctg aatttcaagt tcaagaaaac
     3481 cctgttcatt cacatttttt gatgggcgat attgaatttg atgacctttc ttataagtat
     3541 ggttttggac gagatacctt aacagatatt aatctcacga ttaaacaagg agataaggtt
     3601 agcctagttg gagttagtgg ttctggtaaa acaactttag ccaaaatgat tgtcaatttc
     3661 tttgaaccct acaaaggaca tatttccatc aatcatcagg atattaaaaa cattgataaa
     3721 aaagtcttgc gccgtcatat taattaccta ccacaacaag cctatatctt taatggctct
     3781 atcttggaaa acttaacttt gggcggtaat catatgatta gccaagaaga tattctaaga
     3841 gcttgtgaat tagctgaaat tcgtcaagac attgaaagaa tgcctatggg ctatcaaact
     3901 cagctctctg atggagctgg tctatcagga ggacaaaagc aacgaatagc cctcgctcgt
     3961 gctcttttaa ctaaatctcc tgttttaata ctagacgaag ctactagcgg tcttgatgtc
     4021 ttgactgaga aaaaggttat agataatctt atgtctctaa ctgataaaac cattctcttt
     4081 gtagcccatc gtctcagtat agccgaacga accaaccgtg tcattgttct tgaccagggg
     4141 aaaatcattg aagttggtag tcaccaagag ttaatgcagg cgcaaggttt ctaccatcat
     4201 ctattcaata aataaggaga atgtcatgaa tcctaatctt tttagaagcg tcgagtttta
     4261 tcagagacgt taccataact atgcgacagt gttaattata cctctttcat tactatttac
     4321 tttcatcttg attttctccc ttgttgccac aaaagaaatt actgttactt cccaaggaga
     4381 aatcgcccct acaagtgtca ttgcctccat tcagtcaacc agtgataatc ctatcctagc
     4441 taatcattta gtggcaaatc aagtagttga aaaaggggac ttactcatca aatactctga
     4501 aacaatggaa gaaagtcaga aaactgcctt agcaactcaa ttacaaagac ttgagaagca
     4561 aaaagaagga cttggaattt tgaaacaaag cttagaaaaa gcgactgatc ttttttctgg
     4621 cgaggatgaa tttggctacc ataatacctt tatgaatttt actaaacaat cccatgatat
     4681 tgaactgggt atcacaaaga ctaacaccga agtttcaaat caagctaatc tttccaatag
     4741 cagttcatca gctattgaac aagaaattac aaaagttcaa caacaaattg gagaatatca
     4801 agagttgaga gatgctatca taaataacag agcacgctta ccaactggca atccgcacca
     4861 gtcaattttg aatcgttatc ttgtagcctc acaaggacaa acacaaggaa ctgcagagga
     4921 gccattttta tctcaaatta atcaaagtat tgcaggtctt gaatcatcta tcgcaagcct
     4981 caaaattcag caagctggta tcggaagtgt agcaacttat gataacagtt tagcaaccaa
     5041 aattgaagta ctccgcactc agtttttaca gacagcctca cagcaacaac taactgtgga
     5101 gaatcaatta acagaattaa aagtacaact agatcaagcc acacagcgtt tggaaaacaa
     5161 taccttaacc tccccaagta aaggtatcgt tcatctgaac agcgaatttg aaggtaaaaa
     5221 tagaattcca actggtacag aaattgctca aatattccct gtcatcacag atacaagaga
     5281 agtactaatc acttactacg tatcttctga ctatctacct ctactagata aaggacaaac
     5341 tgtaagatta aaactggaga agattggaaa tcacggcacc accatcatcg gccaacttca
     5401 gacaattgat caaactccta ccagaacaga gcaaggaaat ctctttaaat taaccgctct
     5461 tgcaaaacta tctaacgagg atagtaaact catccaatat ggcttacaag gtcgcgtcac
     5521 tagtgtaact acaaagaaaa catattttga ttatttcaaa gataaaattt taacacattc
     5581 tgattaattt tcagataaca ctctataact atttattatc ttatcaaaaa ggagaatcat
     5641 aacatggata agaaacaaaa cctaacttca tttcaagaac taacaactac cgaactcaac
     5701 caaattacag gtggaggatt gtgggaagat ttattatata acattaatag atatgctcat
     5761 tacatcacat aagaacttca tcatccaata caactataaa aaaataagac cgagaaacaa
     5821 gtactctcgg tcttattttt catcattctg tatgtatcac agtaagtacc tgacgaaaga
     5881 cttgattttg acaggtggta tttagactgg tattaggatg gctttccaca atcttcatga
     5941 cggtatagag accaactcct ctctcctccc ctttagaact ggctccaaag gagaagattt
     6001 cagaaatatc gatgccctct tctttgatgg agttttcgat gataaaggtc tcctgtgctc
     6061 cattttttaa aaaggcgatt gaaacatgag gttgactagc ttccacactg gcttcaatag
     6121 cattgtcaca aaggatagac acaatggtta gaaaatcaag tagactcatc ccctcgacct
     6181 gaatctcctc aggaacttcg acattaaaga caatgttctt atctctggct tttaaaaatt
     6241 tccctgctag aagacttttg agggctttat cacgaatatt taccaatctg cccaggtcat
     6301 atttattgtt ctgcaatttc tgactggaat cctttaagac ggagccatag acctctttta
     6361 tctgctccat atcctcctct tcaatgccca gacgtaagct agtcaagagg ttggtataat
     6421 catggcgaaa actccgtact tccttgtaaa gctcctctat atgccgacta tagcgttcca
     6481 tatctctata gcgcagggcc tgctcttgtt ccaatctctc atagagtttt tccttcaaat
     6541 aggtatccaa tttcttgata acccccataa aaaagagtag gtaaaagact aggatgagat
     6601 ggcgaacagt ctttgattga atactttgtt catattcaaa aaaagacaga ctttccatga
     6661 ctagatagta gccacccatt atccagttaa tctgagtcag ggacttttga aaggctttat
     6721 cgagaatctc ctttctcaag ctagtaaaat cgtagtccaa ccatttcaaa aaagctagag
     6781 aaatgaagaa attgaaaatt attatacata acccagtaaa tgagtagcca tcatatactt
     6841 gcccttgtcc caaaaatgga agcacaaaat aggagactcc tctataaaag agattcacca
     6901 atatcattgg aaagagacca taaaagaaaa ggagtttttt aggaagccct ctcaataata
     6961 agaaagataa gcctatgccg tacaagggtt ccataaaata agataggtaa acatttccta
     7021 ctatatagct aatcatcaca aaaacaaagg ccaacagtat cttaaaaaga aaggccttaa
     7081 aaatcctctc gaaagcaaga tcaattccat ccaccttaaa gaagatgaca atttctagtc
     7141 cattagtaac aagtgtatac aacaatatcc aagcaatgtt cataaattct cctagctcag
     7201 tgtaatttat tgatggcctc agacacttcc ctgaccttat aacgggcgat tagacaactt
     7261 ccaccattgg gaaagaaaag cagtttttct ttcttatcca aatgcaccac atttgcagga
     7321 ttgatgagaa aagagcggtg gcactgcaag agacggggct cctgcttgaa aacctcctct
     7381 aaactcgctg taaattccag cctgtctgtc ttggtataga gaataacacg atgggctctg
     7441 ggcgacgttt cgagatagta aacctcttta aaaggatact gaaattgggc aaattttgat
     7501 ttaaagtaaa agcaatcttc cgccagactt ttactatctt gactattggc atagaggagg
     7561 gctgtctcga tccgagattc aaactcctct gctgacaagg ccttatcaat gtagtccaaa
     7621 gcagacactt ggtagcgaaa agacaggggc ataaactccg agtgagtcgt cacaaagaca
     7681 atcagggcat aaggatcccg atcccgaatc tttctagcca cttccagtcc cttcatctct
     7741 tcatttcgaa tctcaatatc caaaaagaat agctgatggg cccccttctc atgcacttca
     7801 gccagcagtt ggtccggctt gccaaatacc tcaaaagagc taggaatgat atgatgtgct
     7861 ttcaaaagtt tctcaatcgt cgtttcaatt ctagtctgtt gggaaaaatc atcctctaaa
     7921 acaaatattc tcatcttctt actctccctc tttcaaccat ttttgacgaa tttctctata
     7981 gcgacgtctg gcatacttga cagcgtattg accttcttct ccgagaaaaa ggattctttc
     8041 ttgaaaatca atcgatttta atttatcaag attaaccaaa caatttcgat gacatctcat
     8101 caaggtttcc ccacattggt tctcaagatt acttaaattt tgaagcatat taaaactagc
     8161 ttcttctgta acaatctgta cggtatgggc tttagttgga tgtgtttgga tatagtagat
     8221 atcgtcgatg tttactttat agactgtttt ctgcgtctga ataatcatat atttcattgg
     8281 attctcctcc taagaaaaga ataacagaaa aggtctagcc caagcacacc caatcctaaa
     8341 cagtctttga aaactcctaa aaggattatt tttctacaac atcatgatga gcttacaact
     8401 attttatcat aaaattcact cagcgcaatt caagacattt caatgacaat taaagatttg
     8461 aataaaaaaa aagaattaaa aatgataaac taacagtatc aaaacacagt tgccagaagt
     8521 aagactggca cccagattaa aggaggcatt cccatgacag atacagaccc catcaaaaga
     8581 gctcatactt tgattactga cttaaacaaa gcctaccaag catgcaaaca ggcaagcgct
     8641 gacgacgtcc gctttcagga gcaattaaac tctattcttg gttttctagc caaggctgaa
     8701 acagtggata atcgattctt gattgaacta gaaaaatttt accagacttc cagtcttctc
     8761 atgggactca gcgctcttga tccagatgct ccaactcgcg ccgcttggcg ggcctatgac
     8821 cgcttccact ttgaccaagt caagaccaag ttaatactca atgaaaatca aagagcaaac
     8881 taggaagcta gccgcaagct gtacttgagt acggtaaggt gacgctgacg tggtttgaag
     8941 agattttcga agagtataag tctctacgga ccaaccatta tcctgtagta acaaaaaaga
     9001 agctgagaca gactgaactc aacttctttt ttagtgtcgt atcagcaatg ttagtcctgc
     9061 atctgacgtt ttacctgata aggcaaatac aagactagta aaaccaaacc agctcctagt
     9121 aaggctagaa gggccagttt ttcttggaag gtaatcaacc caacaactaa ttccacaagt
     9181 aaaacaaaac tggtcaatcc tcgaactacc tcctgtaagc ctttttcctt ttgccccttg
     9241 tccagcggaa agagttgggt caaatactgg tagtcaaagg catgatagag ggccagcaac
     9301 tggaagagca agaggtagtt aaagagaact accactgctg tcgcaatcca agcttgctcg
     9361 ataaaaacct gcgccagtac ggaaagtaat agaagacgaa gactgagagc aaagaggtcg
     9421 ccatttcgca gataagaacg cagatagaga ttttgccaaa tcttcccagg caccttctga
     9481 acagccttta agataaagtc cagataggca cgacgcttaa cgctgtttga aattcccttg
     9541 acctgcgtaa agagggcaaa gaaacgaagc aagacttgct tacgcttgct ttcttgagaa
     9601 ataacatagt cccagtccag tccagtttca gtgaaaaatt tgctggcctt ttgacgaaag
     9661 tggaaatatt ttcctacccc caataaaagc acatagagca gaaaaactgg caagccataa
     9721 cccattgcta aaaataaagg cgcaaataac agcaagaaaa gggtctgtac aaagagccaa
     9781 aagactaggg aaatgccagt ttgacgcttg agatggagct tgatttcctc ttctccaact
     9841 aagagaaaga gcttgtctgg agcctccata taggtggcaa ttcctcccca aagtaaaagt
     9901 aaaacagacg taattcctac aaacaaaagg ataggccaat gattttcagg aaaatgttgt
     9961 aagagttgac tgtactggta ggctagaaag cccaacagga caagcaggaa caagacaaag
    10021 tggtcattga gcacatagcg cagataacca agacactcct tacgaaaggc ctgctttctc
    10081 tttaaaaaca agtctttcat agatcctcct ctttggtcag agccaagtaa atatcattca
    10141 aactagcctc aggcatatca aaggcttcac gtagttgcag gagattgcct ttggcacgca
    10201 cctctccctt gtgaagaatg acaaaggcat cacacatctt ctccgccgaa tccagcacgt
    10261 gggtactcat gagaatagac ttgccctttt gcttctccac ttccaaaagc tgaatcaaat
    10321 cagaaatagc cagcggatca agaccaagga aaggctcatc cacgatgaaa agacttggat
    10381 ccaccacaaa agcacagata atcatgacct tctgcttcat cccttttgaa aaatgaacag
    10441 ggaaccagtc taatttctgt tccaaacgga acatttttaa caagggctct actcgttcga
    10501 aagtcacttt ttgctcaata ccgtaagcca tagcaaccgt ttcgatatgc tctctgagag
    10561 tcaattcctc atacagacta ggcgtctcag gaatgtagcc aatttgcttg cggtagctcg
    10621 ttgcatcttc ttgcagggtc aagccattaa tattgatgga accactataa ggtgtcaaca
    10681 gaccgataat ctcattaatg gtcgtcgatt taccagcacc attgagacca atcaaaccaa
    10741 ccagctgccc actttcaacg gtaaaggaca catctttcaa aacaggaaca tgaacatagc
    10801 cacctgtcag gtttttaatt tctaacatat tttctccaaa tctggtataa tgtagctata
    10861 ttatatcaaa attcagtaca gtagaggtag attttatgtc agattgcatt ttttgtaaaa
    10921 tcatcgcagg ggaaattcct gcttcaaaag tatatgaaga tgagcaggtc cttgcctttc
    10981 ttgatatctc tcaagtaaca ctaggacaca ccttggtcgt gccaaaagaa cactatcgca
    11041 atcttttgga gatggatgct acgagcgcca gccaactctt tgcccaagta ccaaaagtag
    11101 ctcaaaaagt catgaaagtc actaaggctg ctggtatgaa tatcatttcc aactgtgaag
    11161 aagtcgctgg tcaaacagtt tttcatactc acgttcacct tgtgcctcgc tacagtgctg
    11221 acgatgacct caagattgat tttatcgccc acgaaccaga ctttgacaaa cttgctcaag
    11281 tcgctgaaac catcaaaaac gcttaaggag ttgctatgaa attatccaac ctactgctat
    11341 ttgcaggagc tgcagccgga agttatctgg ttacaaaaaa tcgccaaacc atcacagatg
    11401 aagtcttgaa taccactgac cgcgttcaag ctatcaaaga cgatgtggat attatccaaa
    11461 atagcctgca aatcatcgac cagcaaaaag aacttatcaa ggaataccaa gaagacttga
    11521 cttacaagtt taaggtcttg gaaaaggata tccagactag actagctgtg ataaaagaaa
    11581 tgcagggaac tgaagataag taaaaagagc cccccggctc ttttttaaaa cgtaaacaag
    11641 ttatagtgaa ttgaatttag aatagcacat catagtttct aaagcattgt tagagattac
    11701 tttaaaatcc tcttatcaat ttgttcatat tctatttcaa tctactatat atatcccatc
    11761 aactatgcat cataatttag gtaactcata ctcaataaaa atcaaaaagc aaactagaaa
    11821 gctaggcaca gactgctcaa aacaccgttt taaggttgtg gatagaactg acgaagtcag
    11881 ctcaaaacac tgttttgagg ttgtagatac gactcacata tatacggcaa ggcaacgctg
    11941 acgtggtttg aagagatttt cgaagagtat tattctccat caaaggcatc ttttatatgg
    12001 tcaaagaagc cttttttctt tggatttact ttcaagtcac cagcagccgc gaattctttc
    12061 aaggctactt tttggcggtc gttcaagcct gtcggtgtta cgacattaac agtaacgtat
    12121 tggtcaccaa ctgcaccgcc acgaaggctc ggtgccccct tactacgtag gcggaatttc
    12181 ttaccagtct gagttccctc tggaataacc aattcaacat caccgtgaac agttggaata
    12241 tctactgtat caccaagagc cgcttggaca aagttgaggt tgagattgta gaagatagtc
    12301 gttccttcac gttcaaactt gtcgctagct tctacagaaa ctactacata caagtcccca
    12361 taaggtccac cgttaaagcc tgcttcgcct tgaccagcga ggcgaatttg ttgacctgtt
    12421 tccacaccag cagggatttt cacatgtacg ctatgagctt gtttctcatg acctgttcca
    12481 tgacaggttg tacatggata tttgatttct tttcctcgac cgtgacagac atcacaggtt
    12541 acttggcgac gcatcatacc aagaggagtc tgcgtatcga cgttaatgac accagcgcca
    12601 tgacagcgtc cacaagtgac tggacttgtc cctggcttag caccagagcc attacatgta
    12661 cgacagccag cttcacgatg atacttaact tccttctcag ttccgaagat agcttcttca
    12721 aaggtcaaat tgacacgata ctggagatca tctccttggc gaggagcgtt tggattgcgc
    12781 gaagaaccgc ctccgccgaa gaaacttgag aaaatatcct caaaaccacc gaagccacct
    12841 gccccattga aaccaccgaa accaccagct ccaccaaaac caccattggc gcctgcagca
    12901 ccatactggt cataggcagc acgtttttgg tcgtcactca aagtctcata ggcttcttga
    12961 acttccttgt acttgtcctc agcaccaggc tccttgttga tatctgggtg atattttttg
    13021 gaaagcttac gataagcctt tttgatttcg tctgccgaag cgtttttgga tacccccaga
    13081 cgatcataaa attcagtatt gttcatacaa gataccaaga ccgtaaaatt cgactgaaaa
    13141 ataggaaatc tgacgctgga gcgacgctcc tagacagatt tctctttttt ccgagaattt
    13201 aggtcgggtt caattccttt cttttatatt gatgagataa tactccagcc actcggccct
    13261 atcccttttt atcgaaaaac agaggctggg ttgcaacctc tgcaaataag taaattaact
    13321 ttattttgat tttaaatatc ctataagtac agaaatattt atatattttt gtctcttctt
    13381 agtatttgct atataattcc aattgatcat aagaaataca actactgtcc aaatcatacc
    13441 aattatgaac ggtattacaa atttatatgt ttgtatttct aatgatatca tagctgatac
    13501 cagcgccgat acaaatgcag acaacaatac tgaggtaaca aaattcctta ccgcttcatc
    13561 atttttgata caactatcat gttcagctaa tataatttct ctatatctag ctaaatattc
    13621 tattggaata ttatcaataa aatcttttga tgttctatag ttatcagctt gattacaaaa
    13681 atcattataa acttttcgtg tattttttag atactcttca tccaatacac tcgtcttact
    13741 tttccgtaaa ctctccgtct acgacgtcat cgcctgcgtt tcctgttgct tgtgcgcctt
    13801 ctgctccttc ttgagcttgt tgcgctgctg cggcttgttc gtagagttta acagcaagtc
    13861 cttgagcttt ttcgttcaat gcttcaagtt tcgctttcat gtcgtccaag ttgttgtctt
    13921 cttgagcttt cttaaggtca tcaagggcag cttgggcagc gtcacgttct gcgtcgaagc
    13981 ctttaccttc agtttccttg attgtctttt cagtcgcaaa gattgcttgg tctacttcat
    14041 tacgaaggtc tacttcttct ttacgtttct tatcagcttc agcgtttgct tctgcatctt
    14101 tcatcatgcg gtcgatttct tcgtcagtca aacctgagtt cgattggatg acaatagttt
    14161 gttctttttg agttccaagg tctttggcct taacagacac gataccgttc ttgtcgatgt
    14221 caaatgttac ttcgatttga ggaattccac gaggtgcagc tgggatatca gtcaattgga
    14281 agcgtccaag agtcttgtta tctgctgcca ttgggcgttc accttgaaga acgtggatat
    14341 caacggctgg ttggttgtct gctgctgttg agaagacttg tgatttagat gttgggattg
    14401 tagtgttgcg atcgataagt tttgtaaata ctccacccat tgtttcgata ccaagtgaca
    14461 atggcgttac atcaagaagg acaacgtcct tgacatcacc agtaatcaca ccaccttgga
    14521 tagccgcacc catagcaact acttcatcag ggtttactga tttgtttggt tctttaccag
    14581 tttcagcttt aacagcttca acaacggcag ggatacgagt tgaaccacca acaaggataa
    14641 cttcgtcgat ttctgacaag ctcaaacctg catctgaaag ggcttgacga actggaactt
    14701 ttgtacgttc aacaaggtca cgagtcaaat cgtcaaattt cgcacgagtc aaagtcattt
    14761 ccaagtgaag aggtccagcc tcacctgcag tgataaatgg caagctgatt tgtgttgaag
    14821 ttacaccaga aaggtctttc ttcgcttttt cagccgcatc tttcaaacgt tgcattgcca
    14881 tcttgtcagt agacaagtcg ataccgtttt ctttcttgaa ttctgctacc aagtggtcaa
    14941 tgattttttg gtcaaagtcg tcaccaccaa gtttgttgtc ccctgcagtt gacaatacgt
    15001 cgaagacacc gtcacccaat tcaaggatag agacgtcgaa tgtaccacca ccaaggtcaa
    15061 ataccaagat tttttcttct ttgtcagtct tgtccaaacc ataagcaaga gctgctgcag
    15121 ttggttcgtt aacaatacgt tctacttcaa gaccagcaat tttaccagcg tcttttgttg
    15181 cttgacgttg agcgtcgttg aagtaagccg gaactgtgat aacagctttg gttactttct
    15241 caccaaggta gtcttcagcg tagcctttca agtattgaag gatcatagct gagatttctt
    15301 gtggagtgta ttcttttcca tttgcagaaa ctttttcaga agttcccatc ttagatttga
    15361 tagagataac tgtatctggg tttgtgactg cttgacgttt tgcagcatcg ccaacgataa
    15421 tttctccgtt tttgaatgag actacagatg gagttgtgcg gtttccttct gggtttgcga
    15481 tgattttgct ttcagttcct tcaagaactg caactgctga gtttgttgta cctaagtcaa
    15541 taccgataat tttagacatg tgtttttctc cttgttagtt aattttctat ttttcttttt
    15601 gatactcttc ttaagtggcg acgccgtcag agcttgactt cgtcagtctc tttgactaaa
    15661 ctttgagcct aaggtctcaa aatttgcgca aatagcgcca cggcgaagag tatcgtcttt
    15721 ggttcgcttc gctcactatt acaaagcaaa acatatttta tctttcttca tagtttattg
    15781 tcgtttcgga caagttttct attatgtaaa ttgcgacacg aggagtcgaa atcgatttta
    15841 tttcgacgac gagttagtaa ggaagctagg caaacgccat agcaattgcc gttttctgac
    15901 gagttgcttt agctaccgtc agaattgccg aatcgaacac gccctaagct ctgagtaaaa
    15961 aagatagatt ttcttgtgtt catcgaacac ttcgttaatc tcctattttt actgcgagct
    16021 ttttacgggc tttgtatctt agttatacac cactaccatt gctgggcgta ggatgcggtc
    16081 atggagtttg tagccttttt gaaagacttg ggcgatggta tctactgggt gttcatcgtc
    16141 tgctgggaga gtttggatgg ccatatggta gttatggtca aattcgccat ctgctgcgat
    16201 ttcttcaatt ccttcttctt tcaaagcgtg aatcaagctt tcttgcacca tccccaagcc
    16261 cttcttcaca tcatctgtca aaccttcaac tgcaagtgca cgctcaaggt tgtcaagaga
    16321 tggtaagatt gcttttgcca agtcctggct acgataacgt tgcaagtttt gacgttcttc
    16381 attggcacgg cgttggatat tttgcatttc tgcatgagcg cgaagatatt tgttttcgaa
    16441 ctcatctgca cgttcatttg ccaagtccaa ctcagacttt tcaggagttg tttcttcagc
    16501 tgtttccaca acttcctctt cttgaacttc ttctacttct tcatttttta tatcttgggc
    16561 catgttcgcc tcctttaatg atttcaatct taatgtactt cgtaatgatt actgctgagg
    16621 tagcggtaaa aatctgtcaa cttcatggtc aaaacacggt tgaccacatt gacttgattg
    16681 attagctgtt ggtaatccag attaactgga ccgataatgg ctagaattcc aactccccga
    16741 taaggaatga ggaacttact actaattacc gctaggtcag ctaaacaaga ctcttgaccg
    16801 tctgcaacac gaacattttg catctgatcc tcacgcaacc cctcacgaat ctccaaggcc
    16861 accttttgcg gttggtcaaa gaactgatag gctgctagat tggcaaaatt caagagatgg
    16921 accttgcccg ccatcacaat gttttcgttg aacatttcct taaagatgtg ttcaaagaga
    16981 tcgatgacat tatccgttgt tgtaaagtaa cgctggataa tctgcggaat ctccgtccga
    17041 atcttgtagt gaatatctaa aacggtgtga ccgaggaaac gttcctgaat gatgctcttc
    17101 agtttcagca aatcctcctg caagaagttc cttggaatca gaaactgact agtaaccgtt
    17161 cgcgactcgt ctagggtaaa taccgccaag gctgtatgtt gccccaaaac aacgatatca
    17221 aaggctgtca aacgttgcct gctcggctca acatccagtg ccactaccgt acagccactc
    17281 aggtctgtta acaagttagc agcctcttgc agaatatcct ccaatttgaa gaattcctga
    17341 tcaaaggctt tgacaatctc atatacctca ttttcagcca gtcggtcaaa atccagtgag
    17401 tgtttcacat agtactgaaa accagcaaca cttggcatcc gaccgcttga agtatgagcc
    17461 ttctcaagca acccttgttt ttctagttcc gccatgtcat tacgaatggt tgcactgcta
    17521 gagttaatag actcttgcaa ggcttttgat ccgacaggtt cgtgcgtttt ggtaaagatg
    17581 tcaataatca gatttaaaat atcctgctga cgctctgtaa ccatctcatc actcctctct
    17641 gtctgatcaa ttagcactca atgcatccaa gtgctaactt atgattctat tatacaccct
    17701 tagaagagaa tgtcaagaca aaaactcaaa aaattagcac tcttttataa agagtgctaa
    17761 aaatcaatct gaagacctag aaccttgcta ttcatctact cggtatttcc tttttagtct
    17821 gaaataacca tgaattagat aagaaatcag aaaagcatat aaaacaaaaa taagaaagaa
    17881 agacatagaa agatcctctc taaacaaact catacaaaca acaagaccac ctaagaaagt
    17941 agctgtacag gaacgaagtc tagatcgcat aacttcccat ttgagcccct tactcatata
    18001 gacttgaacc tctggaagta aatcagaaga cgatttacga agaatcgaac aagaacctgc
    18061 tcctatcaat tcccaacctc tatctctaaa atcttgcagt tcatgcttat actttttaag
    18121 aaatctagaa tcatagatac ggtagatgac atcgtctggt tgaccttgct caaaatagaa
    18181 caaaccaaaa cgactcgttc tatacctcca acctttcaaa tgcatctcat gtaaatattc
    18241 ttcttacttg tccaaatcag gaatagtgaa aatccgaaat tctactctgc tattcattgt
    18301 cttaccccaa aattagaaaa catgcctggc gttatttatt agataattct ttccactttt
    18361 gactcaatct ccaaaaaata taagaaatct gaatcgcaaa aactattaat aaaacccaat
    18421 ctattatgaa aatcaaaaat actccccaac tgaaagaact acctccagtg acaaactttg
    18481 agaaaaacgg tagtagagct aaaaagagaa gcaaaatagg aagcatccgc attgttaaaa
    18541 tccgtttggc ataaaaaatc tttatttaaa cgaaaatatt atggcaaaat ttacgccagt
    18601 ttttgaacgg ctgatgtaga tattttatac tttcaaaatg tttaaatgtg attatttatt
    18661 tttgaaaaat agctcaccag cccgactgaa agtgcttata gaatgataat aagtcgcctg
    18721 ccgaaaacag cggaaaatag cggtgttatg cggagataat ctgacgcgat gcgaaagtat
    18781 attgcatact tattttcaac aatttagcag agtattttta taagtgtgat ataatagaag
    18841 tataatttgt tctgatagtt tattttatgg agaagtagat ttttagaatg cggagggttc
    18901 aatatggttg agtttataaa gtctaagaaa gaaatgagtg aggaggatat taaagcaaat
    18961 ttcatcactc ctgctattgt atccaaagga tggaaaaatg gtgagcatat cgcttacgaa
    19021 gaatacttca ctgatggtcg aattgaggtt agaggagata aggctcgtcg taaagaagga
    19081 aaaaaatcag actattcact gtattaccaa tttggaactc gaattgcaat tgttgaggca
    19141 aaggataata aacacagcgt tcgagcagga ttacaacaag ctattgaata tggagagatt
    19201 ttagatgttc catttgttta ttcttcgaat ggtgatggct ttattgaaca cgaccgtatc
    19261 acgagagaag aacgtgagct ggagttagac gaattcccta ctcgtgaaga attattttct
    19321 cgtatgacga aggaaaaagg attgacgtac gaaattacag aagctatctc aactccatac
    19381 tatacagacg ccttctcaat gaaaacgcca cgctattatc agcaaatagc tatcaaccgt
    19441 actattgaaa cagttgccag aggacaaaaa cgagtaatgt ttgtgatggc aacaggaacg
    19501 gggaaaacgt tcatggcttt tcaaattatt catcgccttc gaaaagctgg tttggctaaa
    19561 cgagttttat tcttagcaga tagaaacatc ttagtagacc aaacgatggc tgaagacttt
    19621 aggccattcg aaaaggtaat gacgaaaatt acaccaaaac ttttgactgc tcctgaaaaa
    19681 ttaaattctt ttgaaattta tctagggctt tatcagcaac taactggtga agatggaact
    19741 gaaacacatt atcaaaaatt tgacaaagac ttctttgatt taatcgtaat tgatgaagcg
    19801 caccgtggtt cagctaagga agacagtaac tggcgtaagg tgattgatta tttcagttct
    19861 gcgacacaga ttgggatgac cgctactcct aaagaaacca agaatgcttc caatacggaa
    19921 tactttggtg agccaatcta tacttatagt ttaaaacagg gaatcgagga tggttttttg
    19981 gctccatatc gtgttatgag ggttaattta gatgtggatg tggatggtta tcgtccagaa
    20041 actggaaaag ttgatgctaa cggacaatta atagaagata ggtactacgg caggaaagat
    20101 tttgataaaa ccattgtcat tgatgataga acgcaaagag ttgccaagtt tgtttctgat
    20161 tatatgaagc aaaacaatgc acgatttgat aaaacaattg ttttttgtgt tgatattgac
    20221 catgccgagc gaatgcgtgc tgcacttgta aaagagaatc tagacttagt ccaagaagac
    20281 tatcgttatg tcatgcaagt aactggtgac aacgctgaag gaaaagctca actggataac
    20341 tttatggatg tcaattctaa ttttcccgct attgtaacaa cgtctaaatt attaacgaca
    20401 ggagttaatg ctaaaacatg tcgtttgatt gttttagact ctaatatcca atccatgact
    20461 gaatttaaac aaattattgg tcgtggcaca cgtctttatc ctcaaaaggg gaaagaattt
    20521 tttacgatta ttgattttcg aaatgttacc aatttgtttg ctgaccctga ttttgatggt
    20581 gatcctgtga aggtgctgga aacaggtgcg aaaacagtca gtggttctac gcccggtttc
    20641 gtagatgagg aaggtgaccc agtagaaaaa tatatcgtta cagacaagca ggttaccatt
    20701 cttaattcta ctgttcaagt attagatgaa aacgggaaac tgattaccga aagcctgacc
    20761 gactacactc ggaagaatat cttaggtagc tacgccactt tgaacgattt tatcacagtt
    20821 tggcatacgg cggataaaaa gaagcttatc ttagacgaac tttataaaaa aggagtttat
    20881 ctagatgcta ttcgagagtc ggagggaata tcagaacaag aaatcgatga ttttgattta
    20941 ctcctaaaac ttgcctatgg tcaaaaagaa ttaaccaaaa cggaacgtat caataaactc
    21001 aaacaaagcg gatatttata taaatatagt gaggaagcgc gtgctgtttt ggaaatttta
    21061 ctgaacaaat acatggataa aggtattgga gaactcgaaa gcattgaaac attaaaactt
    21121 ccagaatttc agatatatgg tggaaccttc aaaatcatca atacttattt tggagataaa
    21181 aaacgatatt tacaagcaat taaagaattg gagcaagagc tatttacagt agcttaatga
    21241 aaggaaagta tgtcaattac atcatttgta aaaagaattc aagatatcac tcgaaacgat
    21301 gctggtgtta atggtgatgc tcaacgtatt gagcaaatgt cttggttatt attcttaaaa
    21361 atttatgata gccgtgaaat ggtttgggaa ttagaagaag acgagtatga gtcaattatc
    21421 ccagaggaat taaaatggcg aaattgggct catgctcaaa atggggaacg ggtattgaca
    21481 ggcgatgaat tacttgattt tgtcaataac aagttattca aagagttgaa agagcttgaa
    21541 ataacttcaa atatgcctat tcgaaaaacg attgttaaat cagcttttga agatgcgaac
    21601 aactatatga aaaatggcgt cttgttacgc caagtcatca atgttattga tgaagttgat
    21661 ttcaatagcc ctgaagatcg tcattcgttt aatgatattt acgaaaaaat tcttaaagat
    21721 attcaaaatg ctgggaactc aggagaattt tatacgccac gtgcagcgac tgattttatt
    21781 gccgaagttc ttaacccaaa acttggagaa tcaatggcag accttgcttg cggaacagga
    21841 ggcttcttga cttcgactct gaaccgttta agtagtcaac gtaaaactag tgaagatacc
    21901 aaaaaatata atacagctgt ttttggtatt gaaaagaaag catttcctca tcttttagca
    21961 gttacaaatc tgtttcttca cgaaattgat gaccctaaaa ttgttcatgg aaatactttg
    22021 gagaaaaatg ttcgtgaata tacggatgat gaaaaatttg acattattat gatgaatcca
    22081 ccttttggag ggtcagaatt agaaacaata aaaaataact ttccagcaga attacggagt
    22141 tctgaaacag ctgatttatt tatggctgtc attatgtatc gtttgaaaga aaatggtcgt
    22201 gttggagtta ttttacctga tggttttcta tttggtgaag gtgtaaaaac tcgcttgaaa
    22261 caaaaactgg tagatgagtt caacttgcat acgattatta ggttgcctca tagtgtcttt
    22321 gcaccgtata caggaatcca tacgaacatt cttttctttg ataaaacaaa gaaaacagaa
    22381 gaaacttggt tttatcgttt agatatgcca gatggttata aaaatttctc gaaaactaag
    22441 ccgatgaagt cagaacactt caatcctgtt cgtgactggt gggaaaatcg tgaagagatt
    22501 ctggaaggta agttctacaa atctaaatca tttacaccta gtgaattggc tgagttgaat
    22561 tataatttag accagtgtgg ctttccaaaa gaggaagagg aaatcttaga tccctttgag
    22621 ttgattcaga attatcaagc ggaaagagca actttaaatc ataagattga taatgtatta
    22681 gctgatattt tgcagttgtt ggaggacaaa taatgacacc agaacaactt aaagcaagta
    22741 ttctccaaag agcgatggaa gggaaattag tgccgcaaaa tcccaatgac gaacctgcaa
    22801 gtgaattatt aaagagaatt aaagctgaaa aagaaaaact tatcagtgaa ggaaaaatca
    22861 aacgagataa aaaggaaact gagatatttc gtggtgatga tg
//
LOCUS       DBERMM010000029        22672 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.029, whole genome shotgun sequence.
ACCESSION   DBERMM010000029 DBERMM010000000
VERSION     DBERMM010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 22672)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22672)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22672
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.029"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(1..946)
                     /locus_tag="ACL8AS_001416"
                     /pseudo
     CDS             complement(1..946)
                     /locus_tag="ACL8AS_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            complement(1330..2526)
                     /gene="tuf"
                     /locus_tag="ACL8AS_001417"
     CDS             complement(1330..2526)
                     /gene="tuf"
                     /locus_tag="ACL8AS_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HGS1229260.1"
                     /translation="MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSV
                     NQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQM
                     DGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDL
                     LSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPV
                     EDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAG
                     DNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQ
                     FYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGM
                     VTEIEA"
     gene            complement(3437..4306)
                     /gene="gla"
                     /locus_tag="ACL8AS_001418"
     CDS             complement(3437..4306)
                     /gene="gla"
                     /locus_tag="ACL8AS_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000348128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aquaglyceroporin Gla"
                     /protein_id="HGS1229261.1"
                     /translation="MDFTWALKYATEFLGTAILIILGNGAVANVELKGTKGHQSGWIV
                     IAVGYGMGVMIPALMFGNVSGNHINPAFTLGLAVSGLFPWAQVVPYIIAQVLGAIFGQ
                     ALVVATYRPFYLKTEKPNNILGTFSTISSIDHGTKESRYAATVNGLINEFVGSFVLFF
                     AALGLTKNFFGAEVLQFMKQKAIEAGQTVDFSDLAIKAQVAPHTASGLSVAHLALGFL
                     VMALVTSLGGPTGPALNPARDLGPRLLHAFLPKSVLGEHKGDSKWWYSWVPVVAPIAA
                     AIAAVAVFKFLYL"
     gene            complement(4519..5049)
                     /locus_tag="ACL8AS_001419"
     CDS             complement(4519..5049)
                     /locus_tag="ACL8AS_001419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HGS1229262.1"
                     /translation="MVPKTATSTETKTITRIIHYVDKVTNQNVKEDVVQPVTLSRTKT
                     ENKVTGVVTYGEWTTGNWDEVVSGKIDKYKDPDIPTVESQEVTSDSSDKEITVRYDRL
                     STPDKPTPDPGTPKTETPVNPDPEVPTYETGKREELPNTGTEANATLASAGIMTLLAG
                     LGLGFFKKKKMKNNRF"
     gene            complement(5007..6113)
                     /locus_tag="ACL8AS_001420"
     CDS             complement(5007..6113)
                     /locus_tag="ACL8AS_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MucBP domain-containing protein"
                     /protein_id="HGS1229263.1"
                     /translation="MNIILIAKPLRENTNTKANALNNGWARSGSEEFKKFSHFVGVDK
                     GIVRTNVLTGKKLSDKIRKEVDSGDSKLGKGGYFSTGDVLLGKDVVSYTVQVFSENNE
                     RVGVNTQSHRVQYNLPILADFSVIQDTVEPSRTVVEKIIPKLNIPEEEKGKITEEIKK
                     KKKTSELAELISENVKVRYVDEQGRLLSLKNDTGIGEKESDGTYITNKKQLIGTSYNV
                     TDKKLSSMTTTDGKYYTFKEADTNSASLTGNIVSEGRTVTLVYIESEAPTTATVTANY
                     YKEGSQEKLAESVIKADLAIGSEYTTESKTIEGKTTTEDKEDRVITRKTTYTLVATPA
                     NAYQKTVQQLTITTVRMLRKQWFPKQQPLLRRRL"
     gene            complement(6224..6478)
                     /locus_tag="ACL8AS_001421"
     CDS             complement(6224..6478)
                     /locus_tag="ACL8AS_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229264.1"
                     /translation="MLNVDQDFMSISKSNKSDSDWKKTFTVRTTNRLANDLNNVLKQA
                     DKDTPNTPTWLNSAASKAKDDDRAYKLLKTLIPGENYLSC"
     gene            complement(6472..6714)
                     /locus_tag="ACL8AS_001422"
     CDS             complement(6472..6714)
                     /locus_tag="ACL8AS_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000284543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229265.1"
                     /translation="MYQNEDLYKKGLNVELAHQQIKGFFEAEFKNRINGVLNTKIKNS
                     TLNRVNKKTIHRSNKNSMINLKQKQRKMLKNKAILC"
     gene            complement(6836..7369)
                     /locus_tag="ACL8AS_001423"
     CDS             complement(6836..7369)
                     /locus_tag="ACL8AS_001423"
                     /inference="COORDINATES: protein motif:HMM:NF024751.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HGS1229266.1"
                     /translation="MTIFKEQESEKVAEFLDILDNLKDLPIVYIDETGIDRYLYRPYA
                     GAPRGEKVYEKISGRRFERTSIVAGQVDGEFIAPMIYKKSMTSDFFVEWFKTQLLPAL
                     KTPHVIVMGNASFHPKNILDELCIQDKHFFLPLPPYSPDLNPIEQAWAILKKKVTDLL
                     REVPTIFECLECFFKTR"
     gene            complement(7356..7682)
                     /locus_tag="ACL8AS_001424"
     CDS             complement(7356..7682)
                     /locus_tag="ACL8AS_001424"
                     /inference="COORDINATES: protein motif:HMM:NF013842.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
                     /protein_id="HGS1229267.1"
                     /translation="MAYNTDFKQGALDSIKGGHRHVEAAKVFWCWRQNSLHVGKERRE
                     QGNLERKKRVVKKRKIPLEELKAFVEAHPDAFLREIAAHFDCAVPSVWAALKQIKVTL
                     KKDDDL"
     gene            7916..9634
                     /locus_tag="ACL8AS_001425"
     CDS             7916..9634
                     /locus_tag="ACL8AS_001425"
                     /EC_number="5.4.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HGS1229268.1"
                     /translation="MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGT
                     AGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFE
                     SAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
                     GQMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDVEYLKEVKDVNI
                     NPALIEEFGKDMKIVYTPLHGTGEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSP
                     NPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAK
                     YILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEE
                     KHNHTYMMGFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKE
                     YGYYAEKTISVTLSGVDGAEQIKAIMAKFRNNAPKEWNATAITVVEDFKAQTATVADG
                     TVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKIANIEAE
                     INAFVK"
     gene            9745..10092
                     /locus_tag="ACL8AS_001426"
     CDS             9745..10092
                     /locus_tag="ACL8AS_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HGS1229269.1"
                     /translation="MEQFLDNIKDLEVTTVVRAQEALDKKETATFFIGRKTCPYCRKF
                     AGTLSGVVAETKAHIYFINSEEPSQLNDLQAFRSRYGIPTVPGFVHITDGQINVRCDS
                     SMSAQEIKDFAGL"
     gene            complement(10370..11206)
                     /locus_tag="ACL8AS_001427"
     CDS             complement(10370..11206)
                     /locus_tag="ACL8AS_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1229270.1"
                     /translation="MKKWMLVLVSLMTALFLVACGKNSSETSGDNWSKYQSNKSITIG
                     FDSTFVPMGFAQKDGSYAGFDIDLATAVFEKYGITVNWQPIDWDLKEAELTKGTIDLI
                     WNGYSATDERREKVAFSNSYMKNEQVLVTKKSSGITTAKDMTGKTLGAQAGSSGYADF
                     EANPEILKNIVANKEANQYQTFNEALIDLKNDRIDGLLIDRVYANYYLEAEGVLNDYN
                     VFTVGLETEAFAVGARKEDTTLVKKINEAFSSLYKDGKFQEISQKWFGEDVATKEVKE
                     GQ"
     gene            complement(11219..11848)
                     /locus_tag="ACL8AS_001428"
     CDS             complement(11219..11848)
                     /locus_tag="ACL8AS_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HGS1229271.1"
                     /translation="MLELRNINKVFGDKQILSNFSLSIPEKQILAIVGPSGGGKTTLL
                     RMLAGLETIDSGQIFYNGQPLELDELQKRNLLGFVFQDFQLFPHLSVLDNLTLSPVKT
                     MGMKQEEAEKKASGLLEQLGLGGHAEAYPFSLSGGQKQRVALARAMMIDPEIIGYDEP
                     TSALDPELRLEVEKLILQNRELGMTQIVVTHDLQFAENIADVLLKVEPK"
     gene            complement(11858..12499)
                     /locus_tag="ACL8AS_001429"
     CDS             complement(11858..12499)
                     /locus_tag="ACL8AS_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HGS1229272.1"
                     /translation="MSYLFEILPSLLNGASTTVQVFALVLLFSIPLGVLIAFALQVHW
                     KPLHYLINIYIWVMRGTPLLLQLIFIYYVLPSIGIRLDRLPAAIIAFVLNYAAYFAEI
                     FRGGIDTIPRGQYEAAKVLKFSPFDRVRYIILPQVTKIVLPSVFNEVMSLVKDTSLVY
                     ALGISDLILASRTAANRDASLVPMFLAGAIYLILIGIVTIISKKVEKKYSYYR"
     gene            complement(12645..13874)
                     /locus_tag="ACL8AS_001430"
     CDS             complement(12645..13874)
                     /locus_tag="ACL8AS_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HGS1229273.1"
                     /translation="MNNSQQMLQALEEQDLTKAEHYFAKALENDSSDLLYELATYLEG
                     IGFYPQAKEIYLKIVEDFPEVHLNLAAIASEDGQIEEAFTYLEEIQADSDWYVSSLAL
                     KADLYQLEGLTDVAREKLLEALTYSEDSLLILGLAELDSELENYQAAIQAYAQLDNRS
                     IYEQTGISTYQRIGFAYAQLGKFETATEFLEKALELEYDDLTAFELASLYFDQEEYQK
                     ATLYFKQLDTISPDFEGYEYGYSQALHKEHQVQEALRIAKQGLEKNPFETRLLLAASQ
                     FSYELHDASGAENYLLTAKEDAEDTEEILLRLATIYLEQERYEDILDLQSEEPENLLT
                     KWMIARSYQEMDDLDTAYEHYQELTGDLKDNPEFLEHYIYLLRELGHFEEAKVHAHTY
                     LKLVPDDVQMQELFERL"
     gene            complement(13864..15030)
                     /locus_tag="ACL8AS_001431"
     CDS             complement(13864..15030)
                     /locus_tag="ACL8AS_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HGS1229274.1"
                     /translation="MEQKEKHFSLSWFFKWFLDNKAITVFLVTLLLGLNLFILSKISF
                     LFSPVLDFLAVVMLPVILSGLLYYLLNPIVDWMEKHKVNRVIAITIVFVIIALFIIWG
                     LAVAIPNLQRQVLTFARNVPVYLEDIDRIVNGLVAQHLPDDFRPQLEQVLTNFSSQAT
                     VLASKVSSQAVNWVSAFISGASQVIVALIIVPFMLFYLLRDGKGLRNYLTQFIPRKLK
                     EPVGQVLSDVNQQLSNYVRGQVTVAIIVAVMFIIFFKIIGLRYAVTLGVTAGILNLVP
                     YLGSFLAMLPALVLGLIAGPVMLLKVVIVFIVEQTIEGRFVSPLILGSQLNIHPINVL
                     FVLLTSGSMFGIWGVLLGIPVYASAKVVISAIFEWYKVVSGLYELEGEEVKSEQ"
     gene            15174..16187
                     /locus_tag="ACL8AS_001432"
     CDS             15174..16187
                     /locus_tag="ACL8AS_001432"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lactonase family protein"
                     /protein_id="HGS1229275.1"
                     /translation="MKETVYFGTYTRRTSQGIYKADFDTETGQLSNLELFAAEPSPTY
                     LAFDQHQHLYTVGSQDDKGGIAAYQTDGTVLNHVVEEGAPHCYVAVDEKRDLVYAANY
                     HKGQVLVYKRQEDGSLLLSDMDQHSGQGPHENQASPHVHYTDLTPDHYLVTCDLGTDQ
                     VITYDLDQEGKLSKLYTYHSKPGAGSRHIIFHNHYKIAYLICELNSTIEVLIYDGVGE
                     FVRMQVISTLPEAYEGFNGTAAIHLSKDGKYLYASNRGHDSIAVYTILADGSLELLEI
                     VPTHGQTPRDFDLTPDQKFLIVVHQDSDNATVFKRNCDNGRLAELSNEFHVPEAVCIR
                     FAP"
     gene            complement(16232..16651)
                     /locus_tag="ACL8AS_001433"
     CDS             complement(16232..16651)
                     /locus_tag="ACL8AS_001433"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045261 - proton-transporting ATP
                     synthase complex, catalytic core F(1) [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="HGS1229276.1"
                     /translation="MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAV
                     LAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLR
                     AERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL"
     gene            complement(16662..18068)
                     /gene="atpD"
                     /locus_tag="ACL8AS_001434"
     CDS             complement(16662..18068)
                     /gene="atpD"
                     /locus_tag="ACL8AS_001434"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045261 - proton-transporting ATP
                     synthase complex, catalytic core F(1) [Evidence IEA];
                     GO_component: GO:0045262 - plasma membrane
                     proton-transporting ATP synthase complex, catalytic core
                     F(1) [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HGS1229277.1"
                     /translation="MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIV
                     LEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDL
                     EAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVG
                     KTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEP
                     PGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQP
                     TLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQ
                     LGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDE
                     EKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAF
                     RGVGSIEDVIAKAEKMGF"
     gene            complement(18154..19032)
                     /locus_tag="ACL8AS_001435"
     CDS             complement(18154..19032)
                     /locus_tag="ACL8AS_001435"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002895995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045261 - proton-transporting ATP
                     synthase complex, catalytic core F(1) [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit gamma"
                     /protein_id="HGS1229278.1"
                     /translation="MAVSLNDIKTKIASTKNTSQITNAMQMVSAAKLGRSEEAARNFQ
                     VYAQKVRKLLTDILHGNGAGASTNPMLISRSVKKTGYIVITSDRGLVGGYNSSILKAV
                     MELKEEYHPDGKGFEMICIGGMGADFFKARGIQPLYELRGLADQPSFDQVRKIISKTV
                     EMYQNELFDELYVCYNHHVNTLTSQMRVEQMLPIVDLDPNEADEEYSLTFELETSREE
                     ILEQLLPQFAESMIYGAIIDAKTAENAAGMTAMQTATDNAKKVINDLTIQYNRARQAA
                     ITQEITEIVAGASALE"
     gene            complement(19048..20553)
                     /gene="atpA"
                     /locus_tag="ACL8AS_001436"
     CDS             complement(19048..20553)
                     /gene="atpA"
                     /locus_tag="ACL8AS_001436"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045261 - proton-transporting ATP
                     synthase complex, catalytic core F(1) [Evidence IEA];
                     GO_component: GO:0045262 - plasma membrane
                     proton-transporting ATP synthase complex, catalytic core
                     F(1) [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HGS1229279.1"
                     /translation="MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGL
                     ENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGES
                     LIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIG
                     RGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGAL
                     DYTIVVTASASQPSPLLFLAPYTGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLL
                     LRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNV
                     ISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYREL
                     EAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPV
                     DDIVRFEEEFHTFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ"
     gene            complement(20568..21104)
                     /locus_tag="ACL8AS_001437"
     CDS             complement(20568..21104)
                     /locus_tag="ACL8AS_001437"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HGS1229280.1"
                     /translation="MDKKTVKVIEKYSMPFVQLVLEKGEEDRIFSDLTQIKQVVEKTG
                     LPSFLKQVAVDESDKEKTIAFFQDSVSPLLQNFIQVLAYNHRANLFYDVLVDCLNRLE
                     KETNRFEVTITSAHPLTDEQKTRLLPLIEKKMSLKVRSVKEQIDESLIGGFVIFANHK
                     TIDVSIKQQLKVVKENLK"
     gene            complement(21104..21598)
                     /gene="atpF"
                     /locus_tag="ACL8AS_001438"
     CDS             complement(21104..21598)
                     /gene="atpF"
                     /locus_tag="ACL8AS_001438"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045263 - proton-transporting ATP
                     synthase complex, coupling factor F(o) [Evidence IEA];
                     GO_function: GO:0015078 - proton transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HGS1229281.1"
                     /translation="MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEK
                     IASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLE
                     AGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQ
                     LGEA"
     gene            complement(21612..22328)
                     /gene="atpB"
                     /locus_tag="ACL8AS_001439"
     CDS             complement(21612..22328)
                     /gene="atpB"
                     /locus_tag="ACL8AS_001439"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015078 - proton transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HGS1229282.1"
                     /translation="MEESINPIISIGPVIFNLTMLAMTLLIVGVIFVFIYWASRNMTL
                     KPKGKQNILEYVYDFVIGFTEPNIGSRYMKDYSLFFLCLFLFMVIANNLGLMTKLQTI
                     DGTNWWSSPTANLQYDLTLSFLVILLTHIESVRRRGFKKSIKSFMSPVFVIPMNILEE
                     FTNFLSLALRIFGNIFAGEVMTSLLLLLSHQAIYWYPVAFGANLAWTAFSVFISCIQA
                     YVFTLLTSVYLGNKINIEEE"
     gene            complement(22363..22563)
                     /locus_tag="ACL8AS_001440"
     CDS             complement(22363..22563)
                     /locus_tag="ACL8AS_001440"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit C"
                     /protein_id="HGS1229283.1"
                     /translation="MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLM
                     FLGVAFIEGTFFVTLVFSFIIK"
BASE COUNT         6757 a         4874 c         4127 g         6914 t
ORIGIN      
        1 tcttccaaag ttcgaaaggc cttattctta aatccacgtt tacgaatctc tttccacact
       61 tgttcaatgg gttcatctct ggtgtgtatg gaggaataaa ggtaaaacca atattagtcg
      121 gaatctttaa ggtacttgat ttatgccata tagcattgtc cataacgagt aaaagataat
      181 catctggata agcttgtgaa agctcttcta aaaaggcgtt catccactca gtattacatc
      241 caccagctat taagaaaaat gattcgcctg tatgggcatc aacagctcca taacaatagt
      301 gaaattctcg tatatagtga ctatggacat gtggacctac tcctattgga gcccaacaag
      361 atcccagttt actgattcta ccgaaaccag cctcatcttg gtacatcaag cgaaccttac
      421 gaaaacgtct actgctttta aagcgctttc ttttcttctt gaattgagat tttattttta
      481 gacgcgacaa tggtttgagc gtctgctttc ctaggatgtt ctggacgtgg cataatattt
      541 cgccaaccat ggtgcttcaa cagttgatag aaggcatcac gtgtgtagga acgacctaac
      601 tcctttttat aagcctgaaa taaggcatca attgtaacaa attctcctgc ctctgtagcc
      661 ttcaaatggc gggcaagaaa gactttctct tcctcaactg tcatatatgc atggttacgg
      721 ccaccacgtg tttcttgaag gagagagtcg agttcgaact cctcatattt ttttacattt
      781 cgccaaatca ttgtttgatt acagtctaaa agttctataa tctctttata agatttgccc
      841 atatcagacg aaatagaacg atttgaagac gtttatgata tttagctgta cgagagtctt
      901 ttaaaagtgt tttgatggtt tggatttctt ctttaattga tttcatatta ctattgtata
      961 atgctttttg attttagtct agtattatac tcttcgaaaa tctcttcaaa ccgcgtcagc
     1021 ttcgccttgt cgtatagatg ttactgactt cgtcagttct atctacaacc taaaaacagt
     1081 gttttgagca gtctgtagct aactttctat agtaaaatga aataagaaca agacaaatcg
     1141 atcaggacag tcaaatcgat ttctaacaat gttttagaag taaatgtgta ctattctagt
     1201 ttcaatatat tatagtttgc tctttgattt tcattgagta ttagttcaat atctaaaaaa
     1261 agaaccttgc caagcaagat tcttttagtg tctgacttaa ataattgttc ttctgggaac
     1321 taaatcgaat taagcttcga tttctgtaac catacctgaa ccaacagtac gtccaccctc
     1381 acggatagag aatgtagtac cttgttctac ggcgattggg tgaatcaact caacgtcgat
     1441 tgtcacgtta tcaccaggca ttaccatttc agtacctgct ggaagttcga ttgaacctgt
     1501 aacgtcagta gtacggaagt agaattgtgg acggtagttg ttgaagaatg gagtgtgacg
     1561 tccaccttct tctttagtaa ggatgtagac ttcacctttg aatttagtgt gtgggttgat
     1621 tgaacctggt ttagcgataa cttgtccacg ttcgatttca tcacgttgaa caccacgaag
     1681 aaggacacct acgttatctc cagcaagacc ttcgtcaagt tgtttacgga acatttcaac
     1741 accagtaaca actgcttttt gagtttcttc tttgatacca acgatttcga tttcgtcgtt
     1801 gactttaacg ataccacggt cgatacgtcc tgaagcaact gtaccacgtc cagtgattga
     1861 gaatacgtcc tcgactggaa gaagcaatgg tttgtcagtg tcacgttctg gttctgggat
     1921 atactcatca actgtgttca tcaattccat aacgatgtct tcgtatttag agtcaccttc
     1981 aagagcttta agtgctgaac cttggataac tggaagatcg tcacctggga agtcgtattc
     2041 tgacaatagg tcacggattt ccatttcaac caattcaagc aattcttcgt cgtcaaccaa
     2101 gtcaactttg ttcatgaaga cgataaggtg tttaacacca acctgacgtg aaagaaggat
     2161 gtgctcacga gtttgtggca ttggtccgtc agttgaagct actacaagga tagctccgtc
     2221 catttgagca gcaccagtga tcatgttttt aacgtagtcc gcgtgtcctg gagcgtcgat
     2281 gtgagcgtag tgacgttttt cagtttcgta ctcaacgtgc gcagtgttga tagtgatacc
     2341 gcgttcgcgt tcttctggag cagcatcgat agacgcatag tctttaggtt ggttaactga
     2401 tgaaggcaag cgacgtgcca aaacagttgt gatagctgca gttagggtag ttttaccgtg
     2461 gtcaacgtgt ccgatagtac caatgttaac gtgtggttta ctacgatcgt atttttcttt
     2521 tgccatttga gtaaaagcct ccaataaaat atattttata gatagacagt aggcaataca
     2581 gtctaacttt ccttactatt ttatcaaatt tcagctaaat tgcaagtgtt ttacaacgtt
     2641 tttgtgaatt attcttgata aaaatttaac taactaatag aaagtactaa atagacttat
     2701 ccttcaagga gttttcagca ttatccatcc actcacttgc tgaaaatgta aacagtctct
     2761 ggtttatata gtaaaatgaa acaagaatag ggcaaatcga tcaggacagt caaatcgatt
     2821 tctaacaatg ttttagaagt tgaggtgtac tattctagtt tcaatctact atacaacctc
     2881 aaaactgtgt tttgaacaac ctgcggctag cttcttagtt tgccctttga ttttcattga
     2941 gtataaaatt gcagataaaa cgataacaat cataggactc agcagagtca atgtaggtcg
     3001 aagaatagcc ctcctaatcg cttattttat agcaaaatga aataaaaact gaacattttg
     3061 ttgaggaagg taaatcaatt cctcacaatg tttgagaaag aagggaggac tattccaact
     3121 tcaacccact ataaagcaga cttacaagat agggaaccca tctccgataa tatatagtag
     3181 aatgaaaact gcacaatttg attggagaat tcaaaccaat ttctaacaat gttttagaaa
     3241 caagggtcta ttatttcaac tgcaacctac tatagcccat tgaagctgga atagcccact
     3301 gagacttcta aaccactgct ggagaggagt ttgtttagag tttctttcat ttccctaaaa
     3361 aatcaaaaag agagaaccag tctgatcctc tcttacttat agatggtgct cactcaaatg
     3421 ttaaaggagc tatttcttag agataaagga atttgaatac agctactgcc gcaattgctg
     3481 ctgcgatagg tgctactact ggtacccaag aataccacca ttttgaatcg cctttatgct
     3541 caccaagaac tgattttgga aggaaagcat gaaggagacg tggtcccaag tcacgggctg
     3601 ggttcaaggc aggtcctgta ggtcctccaa gtgatgttac caaagccata acgaggaatc
     3661 caagtgccaa gtgagccaca gaaagtcctg aagcagtgtg tggagccacc tgtgctttaa
     3721 tagccaagtc agaaaaatca actgtttgtc ctgcttctat tgccttttgt ttcatgaatt
     3781 gaagcacttc agcaccaaag aagtttttag tcaaaccaag agctgcaaag aacaaaacaa
     3841 atgaaccaac aaactcatta atcaaaccat tgacagttgc tgcatagcga ctttcttttg
     3901 taccatggtc aatacttgaa atagttgaga aagttcccaa gatgttattt ggtttttcag
     3961 ttttcaagta gaatggacgg tatgttgcca caactaaggc ttggccaaag atagccccca
     4021 agacttgcgc gataatgtaa ggtaccactt gtgcccaagg gaaaagaccg ctaactgcaa
     4081 gccctagagt gaaagcaggg ttgatgtgat tcccagatac gttaccaaac atcaaggctg
     4141 ggatcataac ccccatacca taaccaacag cgatgacgat ccagccactt tggtgacctt
     4201 tcgtaccttt aagttcaacg ttggcaactg caccattccc aagaatgatc aaaatggcag
     4261 ttcccaaaaa ttcagtggca tacttcagtg cccatgtgaa atccatttgc tagattctcc
     4321 ttaaaatttt ttagatattc cttattttat caatttttac cctatttagc aactgatttc
     4381 tggaaatatt tttaaaaaaa taggattcat agtttcccag ttcaacgtac ttgtaagcgt
     4441 ttttattctt cacgaaagac ctcattctca aaaccaggaa aaagcccaca tctgtgatct
     4501 tttccttgtt cctagattct aaaatctatt atttttcatc ttctttttct tgaagaatcc
     4561 taatcctaga ccagctaaca aggtcatgat accagcacta gccaaggtag cattagcttc
     4621 tgtacctgtg tttggcaatt cctctctctt acctgtctca taagtcggaa cttctgggtc
     4681 tggattcact ggagtttcag tttttggagt acctgggtct ggagttggtt tatctggtgt
     4741 tgataaacgg tcatacctta ccgttatttc tttatcacta gagtctgacg taacttcttg
     4801 tgattcaact gttggaatat ctggatcttt gtacttgtca atcttaccag atacaacctc
     4861 gtcccagttt cctgttgtcc attcaccgta ggttacaact cccgtgacct tgttctcagt
     4921 ttttgtacgg cttaaggtta caggttgaac aacatcttct tttacatttt ggttcgtaac
     4981 tttatcaacg taatgaatga tacgcgttat agtcttcgtc tcagtagagg ttgctgtttt
     5041 gggaaccact gtttcctcaa cattctcacg gtagtaatag tcaactgttg caccgtcttc
     5101 tggtacgcat ttgcaggagt tgctaccaag gtgtatgttg ttttccttgt gataactcgg
     5161 tcttctttgt cctcagttgt tgttttccct tcaatagttt ttgattctgt ggtatactca
     5221 gaacctatcg ctaaatcagc ttttataaca gactctgcca acttctcttg gctaccttct
     5281 ttatagtaat tggctgttac tgtagcagtg gttggcgctt cgctttctat ataaactaag
     5341 gtcactgttc taccttcgct tacaatattc ccagttaaac ttgcagaatt tgtatctgct
     5401 tctttaaaag tataatattt tccgtcagta gtagtcatgc tactgagttt tttatctgtg
     5461 acattgtagc tggtaccaat cagttgtttt ttattggtaa tgtaggttcc gtcactttct
     5521 ttttctccaa ttccagtatc atttttcaat gatagcaaac gcccttgttc atcaacatag
     5581 cgaactttca cattttctga gattagttct gccaattctg aggttttttt ctttttcttg
     5641 atttcttcgg ttattttccc tttctcttct tcgggaatat ttagttttgg aatgattttt
     5701 tcaacaacgg ttcgtgatgg ttccacagta tcttggatga ctgaaaagtc agctagaatt
     5761 gggagattat actgaacacg gtgactttga gtgtttactc ctactctttc attattctct
     5821 gaaaatactt gtacggtata agaaacaaca tcttttccta atagaacatc cccagtagag
     5881 aaatagccgc cttttcctag tttgctatct ccagagtcca cttctttcct aatcttatca
     5941 gatagttttt taccagtcag tacattcgtt cgcacaatcc ctttgtctac ccctacaaag
     6001 tgggagaact ttttgaactc ttcagaacca gatctagccc aaccattatt aagggcattt
     6061 gcttttgtat ttgtattctc tctcaaaggt ttggcgatta gaattatatt catcggcact
     6121 tagagttgct gctatatctg actcttgaat accaacttcc ttactaccat ttctagcggc
     6181 agtatatgtg tatttatctg tttctacttc tagctgatta tccttaacat gataggtaat
     6241 tttctcctgg tataagagtc ttcagtagtt tatatgctct gtcatcatct ttagctttag
     6301 aagcagctga gtttagccaa gttggggtat taggagtatc tttatcagcc tgtttcaaga
     6361 cattattcaa gtcatttgct aacctattgg ttgtcctcac tgtgaaagtt ttcttccagt
     6421 ctgaatcact tttattagac ttagatatgc tcatgaaatc ctggtcaaca ttcaacacaa
     6481 tatcgccttg ttttttagca tcttccgttg cttctgcttc aaattgatca tggagttttt
     6541 gttgctccgg tgtatagttt ttttatttac acgatttaat gtactatttt ttattttagt
     6601 attaagaact ccattaatac gatttttaaa ttctgcttca aaaaatccct taatttgttg
     6661 gtgcgcaagt tcaacattca aacctttctt atacaagtct tcattctgat acaagtcttc
     6721 attctgaacg atttcggcta cacggtgaat ggtttgatcg tataccgtct tctcttaacc
     6781 agcagtatcc ttagttttaa tgactactcg ataggttcct ttagaaccgt tatagtcatc
     6841 tagttttaaa aaagcattcc aaacattcaa aaatagttgg aacttccctt aataaatccg
     6901 tcactttctt tttcaagata gcccaagctt gctcaatagg attcaaatcc ggtgaataag
     6961 gtggtagagg taagaaaaag tgtttatctt ggatgcagag ttcatccaaa atgttcttgg
     7021 gatgaaaact agcattgccc atgacaataa catgaggtgt cttcaaagca ggtaggagtt
     7081 gcgttttgaa ccactccaca aagaaatcgc ttgtcatgct tttcttgtaa atcatgggag
     7141 ctataaactc tccgtctact tgtcctgcaa caattgaagt tcgctcaaaa cgacgtccgc
     7201 taatcttttc atagactttc tcccctctag gagcccctgc ataaggacga tagaggtagc
     7261 ggtcgattcc tgtttcatca atatatacga ttggtaaatc ttttaggtta tccaaaatat
     7321 caagaaactc agcgactttc tctgactctt gttccttaaa gatcgtcatc tttttttaaa
     7381 gtgaccttaa tctgctttaa agctgcccat actgaaggaa cagcacaatc aaaatgtgcc
     7441 gcaatttccc gtaaaaaagc atctggatga gcctctacaa aggctttcaa ttcttctaaa
     7501 gggatcttac gctttttgac gactcgcttt ttccgctcta agttcccttg ttcacgtctt
     7561 tcttttccca cgtgaagaga gttctgacgc caacaccaaa aaactttggc cgcctcgaca
     7621 tgtctgtgcc ctcctttgat ggaatctaat gctccttgtt taaaatcagt attatatgcc
     7681 atagctttat tagaccatgc ttattttaaa ctaagcaact atatcaatgt tttgttatga
     7741 gaagacttac tttttttact gaaattgaat ttttcctagc ctcaacatca tataacccca
     7801 aaattcaatc tgacctggtt tgaagagatg ttcgaagcag ataaggtttt actaaaacta
     7861 aaaaaaatga tataatcaaa ctgattaaat gttttaaaaa taaaggagaa tttgaatgtc
     7921 ttaccaagaa aattaccaga aatgggttga ttttgtggag cttcctgact accttcgtca
     7981 agatttggaa aatatggacg aaaaaactaa ggaagatgcc ttctatacaa atcttgaatt
     8041 tggtactgca ggtatgcgtg gcttggttgg tgctggtaca aaccgtatca acatctacgt
     8101 tgttcgccaa gctactgaag gattggctcg tttgattgag tcaaaaggtg gaaacgagaa
     8161 agaacgcggt gtagcaattg cctacgatag ccgtcacttc tcacctgagt ttgcctttga
     8221 atctgcggca gttcttgcta aacacggcat caaatcttac gtatttgaaa gccttcgtcc
     8281 gactccagaa ctatcatttg cagttcgtca tctcaactgt ttcgcaggta tcatggtcac
     8341 agccagccac aaccctgctc catttaacgg ttacaaggtt tacggtgaag acggtggaca
     8401 aatgcctcca cacgatgcgg acgctttgac tacttatatc cgtgcaatcg aaaacccatt
     8461 tgcagttgaa gttgctgatg tggaaactga aaaagcttct ggcttgattg aagttatcgg
     8521 cgaagctgtt gacgtagaat accttaaaga ggttaaggac gtaaacatca acccagcctt
     8581 gattgaagaa tttggtaaag acatgaagat tgtctacaca ccacttcatg gtactggtga
     8641 aatgttggct cgtcgtgctc ttgcccaagc aggatttgac tctgttcaag ttgttgaagc
     8701 gcaagcaact gctgacccag acttctcaac tgtaacatct ccaaacccag aaagccaagc
     8761 agcctttgcc cttgctgaag aacttggtcg tcaagttggt gcagatgttc ttgtcgcaac
     8821 tgacccagac gctgaccgtg ttggtgttga agttcttcaa aaagatggta gctacctcaa
     8881 cctttcaggt aaccaaatcg gtgctatcat ggctaaatac atcttggaag ctcacaaaaa
     8941 cgctggaact cttcctgaaa atgccgctct ctgcaaatct atcgtttcaa ctgacttggt
     9001 aacgaagatt gctgaaagct acggcgcaac tatgttcaac gtcttgacag gtttcaaatt
     9061 tatcgctgaa aaaatccaag aattcgaaga aaaacacaac cacacttaca tgatgggatt
     9121 tgaagaaagc ttcggttact tgattaaacc atttgtacgt gataaagatg ccatccaagc
     9181 cgttcttgtc gttgctgaac ttgctgccta ctaccgttct cgtggtttga cacttgctga
     9241 cggtatcgaa gaaatctata aagaatatgg ctactacgca gaaaaaacaa tctctgttac
     9301 tctttcaggt gtcgatggtg ctgaacaaat caaagcgatt atggctaaat tccgcaacaa
     9361 tgctccaaaa gaatggaacg caacagctat cactgtcgta gaagacttca aggcacaaac
     9421 tgctactgtt gctgacggta ctgttacaaa cttgacaact cctccaagtg atgtgttgaa
     9481 atacacactt gctgacggtt catggattgc cgttcgccct tcaggtacag aaccaaaaat
     9541 caagttctac attgcagttg taggggaaac caacgaagaa tcacaagcta agattgctaa
     9601 catcgaagca gaaatcaatg catttgtaaa ataaagacct ataaaagatg agaccaacca
     9661 acctcatctt ttttcgtatc aaatctaagc aattttagaa actttatggc atactagact
     9721 tatcaatgaa agcgaggtaa tctcatggaa caatttttag ataacatcaa agaccttgaa
     9781 gtcactacag ttgtgcgtgc gcaagaagct cttgataaaa aagaaactgc aaccttcttt
     9841 atcggtcgca aaacttgccc ttactgccgt aaatttgcag gtacattgtc aggtgtcgta
     9901 gctgaaacca aagctcacat ttacttcatc aatagtgaag aaccaagcca actcaatgat
     9961 ttgcaagcat tccgctcacg ctatggaatc ccaactgtac caggttttgt tcatattaca
    10021 gatggacaaa tcaacgtccg ttgcgactct tcaatgtcag cacaagaaat caaagatttc
    10081 gcaggattgt aaaaaatcag ctaacaagtc ttaaaatcac aaaaacgcat aatgtaaggt
    10141 gcaaaaacct tgatattatg cgttttattg ttcctaaaac agttacatca gcatttcatt
    10201 acagaacatt ttaattttgg aagtcaaatc aatttttaac aatgttttag aaatcacagt
    10261 gggctattcc atattcaatt atccagattc aatcgctatt atcgttttcc tagattacaa
    10321 aaaaactgcg ttttgctaat caaaacgcag tctcagccac tattttatct tactgtcctt
    10381 cttttacttc tttggttgct acatcttctc caaaccattt ttggctgatt tcttggaact
    10441 tgccgtcctt gtaaagacta gaaaaagctt catttatctt cttaaccaag gttgtatctt
    10501 ccttacgggc tccaaccgca aaagcttctg tttctagtcc aactgtaaag acattataat
    10561 cgtttaaaac accttctgct tctaaataat agtttgcata gacacggtca atcaatagac
    10621 catcaattcg atcgtttttc aaatcaatca aggcttcatt aaaggtttgg tattgattcg
    10681 cttccttatt agcgacaata ttcttcaaaa tttctggatt tgcttcaaag tccgcataac
    10741 cagatgaacc agcttgagct cctaatgtct ttccagtcat atcctttgca gtcgtgatac
    10801 cagatgattt cttcgtaacc aatacctgct cattcttcat atatgagtta ctgaaagcca
    10861 ccttttcacg gcgttcgtct gtagcggaat agccattcca aatcagatca atcgttcctt
    10921 ttgtcaattc agcttctttc aaatcccaat caatcggttg ccaatttacc gtgattccgt
    10981 atttttcaaa aacagctgta gctaaatcaa tatcaaatcc tgcataagaa ccatctttct
    11041 gagcaaatcc cattggaaca aaagtactat caaatccaat agtaatagac ttgttagact
    11101 ggtactttga ccaattatct ccactagttt cgctagaatt tttcccacaa gctactaaga
    11161 acaaagcagt catcagactg actaatacaa gcatccattt tttcatccat ttttcctcct
    11221 atttaggttc tactttcaat aatacatctg cgatattttc agcaaactgc aaatcatggg
    11281 taaccacaat ctgggtcatc ccaagttccc tattttgcaa gattagcttc tccacttcca
    11341 aacgtaattc tggatccagg gcagaagttg gttcatcgta gccaatgatt tctgggtcaa
    11401 tcatcatagc acgcgccaaa gccacccgct gcttttgccc accagatagt gagaaaggat
    11461 aggcctctgc gtgtcctcct agtcctaact gttccaagag tccactcgcc ttcttctcag
    11521 cctcttcctg cttcattccc atggtcttca caggcgataa ggtcaaattg tccagaactg
    11581 ataaatgagg gaacagttga aaatcttgga atacaaatcc cagtagattg cgcttctgca
    11641 attcatccag ctctaaaggt tgtccattat aaaagatttg ccctgaatca atggtttcaa
    11701 gacctgcaag catacgtaaa agagttgtct tacctccacc agaaggtcca acgatagcca
    11761 ggatttgctt ttcaggaata cttagactga aattagacag gatttgtttg tctccaaaga
    11821 ctttattgat atttcgtaat tctaacatgg cagcctccta tctataataa ctatacttct
    11881 tctcaacttt tttggaaata attgtcacaa tcccaatcaa aatcaaataa atggctcctg
    11941 ccaagaacat aggaactaga ctagcatcgc ggttagcagc tgttcgacta gccaagataa
    12001 ggtctgaaat tccgagagca tagaccaaag aagtatcctt gaccaaactc ataacttcat
    12061 taaagacact aggaagaacg atcttggtca cttggggcaa gataatatag cgcactctgt
    12121 caaaagggct aaacttcaag accttggcgg cctcatactg tcctcttgga atagtgtcaa
    12181 ttcccccacg gaaaatttct gcaaagtaag ctgcatagtt gagaacaaag gcaataatag
    12241 ctgcaggaag gcggtctaaa cgaatcccaa tacttgggag cacataatag ataaaaatca
    12301 gttgcaagag taagggggtt cctcgcataa cccagatgta aatgttaatc agataatgga
    12361 ggggcttcca atggacttgc aaggcaaagg caatcaaaac gcccaaggga atcgaaaata
    12421 gcaagaccag tgcaaagacc tgtacagtcg tgctcgcacc attcagtaaa ctcggtaata
    12481 tctcaaataa ataagacata ctgcacctcc taaaagtaat tgttcctatt atagcatgaa
    12541 taaacaagat taccaagtat ttttgtaaaa agattctacc atatacaaat aaaaaccgta
    12601 gctatcaaaa gagataaact acagttctat atgtttaaac attcttacaa tctctcaaac
    12661 agttcttgca tttgcacatc atctggaacc agttttaagt aagtgtgagc atggactttt
    12721 gcttcttcaa aatgtcccaa ttcacgcaag agatagatat agtgttccag aaattctgga
    12781 ttgtccttca aatctcctgt caactcttga taatgctcat aagcagtatc caaatcgtcc
    12841 atttcttgat aagaacgagc aatcatccac ttggtcaaaa gattttctgg ctcctcactc
    12901 tgcaagtcta gaatatcctc ataacgctcc tgctccagat aaatagtggc taaacgaagc
    12961 aagatttctt ctgtatcctc agcgtcttct tttgcagtaa ggagataatt ttctgcacca
    13021 ctagcatcat gtaattcata agaaaattgt gaagcagcta gcaagaggcg agtttcaaag
    13081 ggatttttct ctaatccttg cttagcgata cgcagggctt cttgaacttg atgttcctta
    13141 tgtaaagcct gactgtaccc atactcatag ccttcaaagt caggagaaat ggtatcaagc
    13201 tgcttaaagt agagggtggc tttttgatat tcttcttgat caaaataaag actggccaac
    13261 tcaaaagctg ttaagtcatc gtattctaac tccagggctt tttctaaaaa ctcagtagcc
    13321 gtttcaaatt tccctaactg agcataggca aagccaattc gttgataggt ggaaatgccc
    13381 gtttgctcat aaatcgagcg attatctaac tgggcatagg cttgaatagc cgcttggtaa
    13441 ttttccaact cactatccaa ctctgccaaa cccaatatca agagagaatc ctctgagtag
    13501 gtcaaggcct ccaataattt ctcacgtgcc acatctgtca aaccttccag ctggtaaagg
    13561 tctgccttca gagccaaaga cgagacatac cagtcactgt cagcttggat ttcctcaaga
    13621 taggtaaagg cttcttctat ttgaccatcc tcgctagcaa ttgcagctag attaagatga
    13681 acctctggaa aatcctctac aattttcagg taaatttcct tggcctgagg atagaaacca
    13741 atcccttcaa gataagttgc caactcatac agaagatcac ttgaatcatt ttctaaagct
    13801 ttggcgaaat aatgctcagc cttagttaaa tcttgctcct ccaaagcctg taacatctgt
    13861 tgactattgt tcactcttga cttcctcacc ctctaattca tatagaccac tgactacctt
    13921 ataccattcg aaaatggctg aaatgacaac cttagcagag gcataaaccg gaataccaag
    13981 taaaactccc cagataccaa acatagatcc tgaagttaac aaaacaaaga gaacattaat
    14041 agggtggatg tttaattgac ttcccaaaat caatggagag acaaaacggc cttcaatagt
    14101 ttgttctacg ataaagacaa tcactacttt caaaagcatg actggaccag caatcaaacc
    14161 caatactaga gcaggaagca tggctagaaa gctaccaaga taagggacca gatttaaaat
    14221 accagcagta acccccagcg taaccgcata gcgtagacca ataatcttga agaagatgat
    14281 aaacattact gctacaataa tagccactgt cacttgccct cgaacatagt tggacaactg
    14341 ttgattcaca tctgataaaa cttgtccaac aggttccttc aattttcttg gaatgaattg
    14401 ggtcaaatag ttacgcaagc ctttcccatc acgcaagaga taaaagagca tgaaaggaac
    14461 gataatcaag gcaacaatca cttgagaagc tccgctaata aaggcactca cccagttgac
    14521 tgcctgagat gaaaccttac ttgccaaaac tgtagcctgg ctagaaaaat tggtcaaaac
    14581 ttgctctaat tgaggtctga aatcatctgg caggtgctgg gctaccaatc cattaacaat
    14641 cctatctata tcttctaagt aaacaggaac gtttcttgca aaggtcaaaa cctgacgttg
    14701 cagatttgga atggcgactg ccaagcccca aatgataaag agagcgatga taacaaagac
    14761 aatagtgata gctataacac gattaacctt atgcttctcc atccaatcaa caataggatt
    14821 caacaaataa tataacaaac cagataaaat gactggcaac atcacaactg ctaaaaagtc
    14881 taaaacaggt gaaaatagaa aactaatctt acttaaaata aaaagattca gtcccaataa
    14941 taaggttact aaaaataccg taattgcctt gttatctaaa aaccacttga aaaaccaaga
    15001 taggctaaaa tgtttctctt tttgctccat aaatacttcc tttctattgt tctctcatta
    15061 taccattttt gaaacaaaat aactcttttt taaagtgctt acatctaatt ggatgtcttt
    15121 aatttgcttg tttttgtgat ataatagtct tatctttaca cagaggtata gtaatgaaag
    15181 aaactgttta ttttggaact tatacacgtc gtacttctca agggatttac aaggcagact
    15241 ttgatacaga aactggtcag ctttcaaatc tagaactttt tgcagctgag ccaagtccaa
    15301 cctaccttgc ctttgaccag caccaacatt tatacactgt tggtagccaa gacgataagg
    15361 ggggaattgc agcctatcaa actgacggga ctgtgttaaa tcatgttgtt gaagaaggag
    15421 ctccccactg ttatgttgct gtcgatgaaa agcgtgattt ggtttacgca gccaactatc
    15481 acaagggaca agtccttgtt tataaacgcc aggaagatgg tagtcttcta cttagtgata
    15541 tggatcaaca cagtggccaa ggtccacatg aaaatcaagc ttccccccat gttcactata
    15601 cagatttaac acctgaccac tatctagtga cctgcgactt gggaactgac caagtcatca
    15661 cctatgacct cgatcaagaa ggaaaattat ctaagctcta tacctatcac agcaagccag
    15721 gagcaggctc acgccatatc attttccata accactataa aatcgcttat ctcatttgtg
    15781 aactcaatag tactatcgaa gttttaatct acgatggcgt tggcgaattt gtacgtatgc
    15841 aggttatttc aactttacca gaagcttacg aaggctttaa tggaaccgct gctattcatc
    15901 tctctaaaga cggtaaatac ctctacgctt ctaaccgtgg ccatgattct atcgcagtat
    15961 ataccatcct tgcggacggt agcttagagt tattagaaat cgttccaacg catggtcaga
    16021 ctccacgtga ttttgatttg acacccgacc aaaaatttct cattgttgtc catcaagact
    16081 ctgacaatgc aactgtcttt aaacgtaatt gtgacaatgg tcgtctagca gaactctcca
    16141 acgaattcca tgttcccgaa gcagtctgca tccgttttgc tccttaaaac accataaaaa
    16201 atgaacttgg tattttcaag ttcatttttt cttatagtct atttccgaca ttaatacggt
    16261 taatggcacg ttgcaaagca atcttagcac gacgttcttg gtcaatcaaa tgtttgtctt
    16321 gtgcttcttc aattgcacgt tctgcacgaa gtttggcacg ttctgcacgg ctaatatcga
    16381 tatcacgagc acgttctgca gagtcagcga cgattgtgat catatcattg gcaatttcaa
    16441 taacgccacc gtttactgca atccagttca cgtgatcttt atcatcgata cgttttacct
    16501 ttacttcatc aactgctaaa accgcaatca tattttcatg tcgtggcaag atccccatct
    16561 caccatccag agttcgaacc gatacatagc tggcatggtg atcatagacg agaccatctg
    16621 gtgtcacgat ctggacagtt aactgagcca taggtcacct cttaaaatcc cattttttca
    16681 gcttttgcaa tcacatcttc gatagaacct acaccacgga aggcatcttc tggcaagtgg
    16741 tcgtatttac catcaaggat ttccttaaag ccacgtacag tttcagcaac tggaacataa
    16801 gaacctggct gaccagtaaa ttgttccgca acgttgaagt tttgtgacaa gaagaactgg
    16861 atacgacggg cgcgagcaac caaggtcttt tcttcatcag aaagctcatc cataccaagg
    16921 atagcaatga tatcttgcaa ttcatggtaa cgttgaagga cacgttttac ttcagcagca
    16981 actgcatagt gctcttctcc aacgatttca ggtgccaagg cacgtgagct tgaagcaagt
    17041 gggtcaacgg ctgggtagat acccaattgt accaacttac gttccaagtt tgttgttgaa
    17101 tccaagtgag cgaaggctgt tgctggcgct gggtcagtat agtcatccgc tggcacatag
    17161 atagcctgga tagaggttac agaacccttc ttggttgatg tgatacgttc ttgcaattga
    17221 cccatttccg tagcaagtgt tggttggtaa ccaacggctg atggcatacg acccaaaagg
    17281 gcagatactt ctgaaccagc ctgagtgaaa cggaagatat tatcgataaa gagaagcacg
    17341 tcttggcctt ccacatcacg gaagtattca gcgattgtca aaccagtaag ggcaacacgc
    17401 atacgtgctc ctggtggctc attcatctga ccaaagacca tggctgtttt ctcgataacg
    17461 cctgattctt tcatttccca gtaaaggtca ttcccctcac gagtacgttc cccaacacca
    17521 gtaaatactg aaataccacc gtgctcttgg gcaatgttgt gaatcaattc ttggattaag
    17581 acggttttac caactccggc accaccgaaa agtccaactt taccaccttt aaggtaaggg
    17641 gcaagaaggt caataacctt gatccctgtt tcaaggattt cagaagaggt agacaactca
    17701 tcaaaagttg gagctttttt atgaattggc tgacgctctg cgtcttctgt aaaaggagct
    17761 tccaaatcaa tggtatctcc caaaacgttg aagacacgtc ccaaagtttc tttacctact
    17821 ggtacagaga ttggacgacc tgtgtccaat acttccattc cacgagtcaa cccatctgtt
    17881 gattccatgg cgatagtacg aaccatacca tctcctaact ccaaggctac ttcaaggacg
    17941 atttttgttt ttctttcgtc atttttgtag acgacaagtg cattgttaat ctcaggaagt
    18001 ttttcccctg ctgcaaacaa aacgtctaca acgggaccga taacctgagc aattttacct
    18061 gaactcatct ccttctccta ttctatataa gatactgtcg gttcctagct caactaggtc
    18121 ctaagttcat tttcatacga gctggactag agcctattct aaggcactag cacctgctac
    18181 gatttctgta atttcttgtg taatcgccgc ctgtctggca cggttatact gaattgtcaa
    18241 atcattgatg actttcttag cattatctgt cgctgtttgc atggctgtca tacccgcagc
    18301 attctcagct gtcttggcat cgataatggc accgtaaatc atactttctg caaactgagg
    18361 caacaactgc tccagaattt cttctcggct ggtttccaat tcaaaagtca agctgtactc
    18421 ttcatccgct tcatttggat ccaagtcaac aatcggaagc atttgttcca cacgcatttg
    18481 actggttagc gtattgacat ggtggttgta gcaaacataa agctcatcaa agagttcatt
    18541 ttggtacatt tcaacagttt ttgaaataat cttacgaact tgatcaaagc taggttggtc
    18601 tgccaagcca cgtaattcat aaagtggttg aataccgcga gccttaaaga aatcagctcc
    18661 catcccaccg atacagatca tttcaaaacc tttaccgtct gggtggtatt cttctttcaa
    18721 ctccataaca gctttcaaaa tagaggaatt ataacctcca accaaaccgc ggtctgaagt
    18781 gataacgata tagcctgtct tcttcacaga acggctaatc aacatcggat tagttgaagc
    18841 accagctcca ttaccatgaa ggatatctgt caaaagttta cgcactttct gagcgtaaac
    18901 ttggaagttg cgagcagctt cttcagaacg acctagctta gcagccgata ccatttgcat
    18961 ggcattagtg atttgactcg tattttttgt tgaggcgatt tttgttttaa tatcatttag
    19021 agatactgcc atctgacacc tctattctta ttggaagcta gattgattga gaaactctgt
    19081 aatcgcagca tccaagactg cttcttctgg caagtctttt gtatcacgaa tggtttccaa
    19141 aatctctgga tgttgagcat caaagaaggt atggaactct tcctcgaaac gaacaatatc
    19201 atctactgga acagtatcca agaaaccatg tgtcaaagca taaagaatgg ttacttgttt
    19261 ctcaacaggt aatggtttgt gaacaggttg tttcaagacc tcaacggtac gacgtccacg
    19321 gttcaactta gcctgtgttg ctgcgtccaa gtcagaacca aacttagtaa aggcttccaa
    19381 ctcacggtat gaagcaaggt cgatacgaag tgtaccagca accttcttca tggctttgat
    19441 ttgtgcagaa ccacctacac gagatacaga tgaacccgca tcgatggctg gacgaatacc
    19501 tgcattgaag aggccatcgc caaggaagat ttgtccatca gtgatagaaa tcacgttggt
    19561 tgcgatatag gctgagatat ctcctgcttg tgtctcgata aatggtaggg ctgtaattga
    19621 tccaccacca agttcatcag aaactttagc tgagcgctca agcaaacggc tgtggagata
    19681 gaaaacatcc cctgggaagg cttcacgacc tggaggacga cgaagcaaga gcgatagttc
    19741 acgataagct accgcttgtt ttgatagatc atcgtataca atcaaaacat gcttaccttg
    19801 atacataaat tcttccgcca tagcaacccc agtataagga gctaggaaga gcaatggaga
    19861 tggttgtgaa gcagaggctg tcacaacgat tgtgtagtcc aaggcaccgt actgacgaag
    19921 tgtttctact tgcgtacgaa ctgttgattc tttttgtcca atcgcgacgt agatacagat
    19981 catatcttga tctttttggt tcaagattgt atcaatcgca atggttgttt tccctgtctg
    20041 acggtcaccg ataatcaact cacgttgacc acgaccaatc ggtacaaggg cgtcaatagc
    20101 tttcaaacca gtttgcaatg gttctgaaac agacttacgt tgcataacac caggagctgg
    20161 tgcttctact ggacgagttt tatcagtgtg gatttctcca agaccgtcaa ctggacgacc
    20221 aagcggatcc acaacacgac caatcagact ttcacctaca gggacttcca tgattttccc
    20281 tgtacggcgg attgtatcgc cttcacggat atctgtaaag tcacctagga tgataatacc
    20341 aacgtctgtt gactccaagt tttgagccat accataagag ccgttttcaa aattcaacaa
    20401 ctctccactc atgacatttt caaggccatg agcacgcgcg ataccgtccc cgatataggt
    20461 tacaacacct gtttcagtca catcaaaatt gggtttgaaa ttttcaattt gttgcttaat
    20521 taaagcgctg atttcttgtg cgttaattgc caaaagaaca ccactttcta tttcaaattt
    20581 tctttaacaa ctttaagttg ttgtttaata ctcacatcaa ttgtcttgtg attggcaaaa
    20641 atgacaaaac caccaatgag actttcatcg atttgttctt ttacactcct tactttcaga
    20701 gacatttttt tctcaatcaa agggagcaaa cgagtcttct gttcatcagt tagaggatga
    20761 gcagacgtaa tcgtcacttc aaatcgattt gtttcttttt caagtcggtt caagcaatct
    20821 acaagcacat cataaaaaag atttgctctg tgattgtagg ccagaacctg gataaagttt
    20881 tgtaataaag gcgacacaga atcttggaaa aaagcaattg ttttttcctt atccgactcg
    20941 tctactgcca cttgttttaa aaaagaaggc agacctgttt tttcaacaac ttgcttgatt
    21001 tgagtcaagt ctgaaaagat acggtcttct tctccttttt caagtaccaa ttggacaaaa
    21061 ggcatgctgt atttttcaat tacctttact gttttcttgt ccattaagct tctcctagct
    21121 gatcgatata ctgatcaatg agtgctttat gggcatgact gtcaaggttt tgtgagatga
    21181 ttttaccagc taagctgatg gtcaaatctg cgacctcacc cttaacactc tgtaaagctt
    21241 ctactttatt ttgagcaatt tcttgattgg ctttttcttt taagtgtcct gcttctagtt
    21301 tagcatctgc taagatatta gccttacttt gctcagctgt ttcctttgca ttttcaatga
    21361 ttgtcttagc ttctttacgg ctaccagcca attcatcttc gcgtttttga gccaatactt
    21421 ctgctttttg acgggcttct tcagctctat caatatctga agcaattttt tcagctcttt
    21481 cttcgaaaat gcctgtaata ttagaccatg caaatttttt aatcaagact agcaaaagaa
    21541 taaaagagcc agtgattaaa ataaaattac caattaattc acctactgtt acgtgcatca
    21601 gttactcctt tctattcctc ttcaatatta atcttattcc ctaaatacac agatgtcaaa
    21661 agagtaaaaa cataagcttg gatgcaggaa ataaagacag aaaatgcagt ccaagccaaa
    21721 ttagctccaa aggctactgg ataccaataa atagcttggt gggaaagaag aagtaacaaa
    21781 ctcgtcatga cctctcctgc aaagatattc ccaaaaatcc gcaaagccaa agataagaag
    21841 tttgtaaatt cttccaagat attcatcggt atgacaaaaa caggactcat aaaagatttt
    21901 atactttttt taaatccacg acgacgaacg ctttctatat gtgtcaacaa aatgacaaga
    21961 aaagataagg ttaagtcata ctgtaaatta gcggttggcg aactccacca gttagtccca
    22021 tcgatcgttt gaagctttgt cattaagcca aggttattgg caatcaccat gaaaaggaat
    22081 aaacaaagga aaaagagtga gtaatctttc atgtagcgcg aaccaatgtt aggttctgta
    22141 aatccaataa caaagtcata gacatactca agtatatttt gctttccttt gggtttcaag
    22201 gtcatattgc ggcttgccca ataaataaag acaaaaataa ctcccacaat caacaaagtc
    22261 atggctaaca tagtcagatt gaagataaca ggaccaatag agatgattgg attaatactt
    22321 tcttccatct aaaatcctcc cttttcttct cgttccatgt atttatttga taataaatga
    22381 gaagacaaga gttacaaaga aagttccttc aataaaggca acacctaaaa acatcaaact
    22441 acgaaactca gaaagcatat ctggttggcg tgctactgat ttaaacagtc cattcatcaa
    22501 taaaccttca ccgacagata cgcccataca ggcaatacat aagcctaaaa atgttaaatt
    22561 cataacaaat tctcctttaa aataaaattt acttacttag tgtagtccta aaatttaaat
    22621 ttgtcaactt ttaaccgcta ttggaagcgt ttaataaaaa ttatttccat tt
//
LOCUS       DBERMM010000030        22664 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.030, whole genome shotgun sequence.
ACCESSION   DBERMM010000030 DBERMM010000000
VERSION     DBERMM010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 22664)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22664)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22664
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.030"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            188..511
                     /gene="tnpB"
                     /locus_tag="ACL8AS_001441"
     CDS             188..511
                     /gene="tnpB"
                     /locus_tag="ACL8AS_001441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HGS1229284.1"
                     /translation="MIIQLSDLGQVHLVCGKTDMRQGIDSLAYVVKTHFELDPFSDQV
                     FLFCGGRKDRFKVLYWDGQGFWILYKRFENGKLTWSSTEKDVKALTSEQVDWLMKGFS
                     ITPQI"
     gene            complement(652..939)
                     /locus_tag="ACL8AS_001442"
                     /pseudo
     CDS             complement(652..939)
                     /locus_tag="ACL8AS_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            921..1450
                     /locus_tag="ACL8AS_001443"
                     /pseudo
     CDS             921..1450
                     /locus_tag="ACL8AS_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050084071.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(1525..2445)
                     /gene="cysK"
                     /locus_tag="ACL8AS_001444"
     CDS             complement(1525..2445)
                     /gene="cysK"
                     /locus_tag="ACL8AS_001444"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004124 - cysteine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HGS1229285.1"
                     /translation="MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVK
                     DRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVER
                     RKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
                     ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPH
                     KIQGISAGFIPDTLDTKAYDGIVRVTSDNALALGREIGGKEGFLVGISSAAAIYGAIE
                     VAKKLGTGKKVLALAPDNGERYLSTALYEL"
     gene            complement(2730..3365)
                     /locus_tag="ACL8AS_001445"
     CDS             complement(2730..3365)
                     /locus_tag="ACL8AS_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HGS1229286.1"
                     /translation="MEFRTIKEDGQVQEEIKKSRFICHAKRVYSEEEARDFITAIKKE
                     HYKATHNCSAFIIGERSEIKRTSDDGEPSGTAGVPMLGVLENHNLTNVCVVVTRYFGG
                     IKLGAGGLIRAYAGSVALAVKEIGIIEIKEQAGIAIQMSYAQYQEYSNFLKEHDLMEL
                     DTNFTDQVDTMIYVDKEEKETIKAALVEFFNGKVTLTDQGLREVEVPVNLV"
     gene            3421..4719
                     /locus_tag="ACL8AS_001446"
     CDS             3421..4719
                     /locus_tag="ACL8AS_001446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HGS1229287.1"
                     /translation="MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCN
                     STILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKV
                     SEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKR
                     LQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPTL
                     YHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLSLPRRFHGNPLIIPKPIWLSD
                     FNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLEEILQEQFPNEKIGFVS
                     SVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGG
                     RVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL"
     gene            4716..5378
                     /locus_tag="ACL8AS_001447"
     CDS             4716..5378
                     /locus_tag="ACL8AS_001447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HGS1229288.1"
                     /translation="MKCLLCGQTMKTVLTFSSLLLLRNNDSCLCSDCDSTFERIGEEN
                     CPNCMKTELSTKCQDCQLWCKEGVEVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFA
                     SFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
                     KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSL
                     VR"
     gene            5458..6006
                     /gene="raiA"
                     /locus_tag="ACL8AS_001448"
     CDS             5458..6006
                     /gene="raiA"
                     /locus_tag="ACL8AS_001448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000599099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0045182 - translation regulator activity
                     [Evidence IEA];
                     GO_process: GO:0009386 - translational attenuation
                     [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HGS1229289.1"
                     /translation="MIKYSIRGENLEVTEAIRDYVVSKLEKIEKYFQPEQELDARINL
                     KVYREKTAKVEVTIPLGSITLRAEDVSQDMYGSIDLVTDKIERQIRKNKTKIERKNKN
                     KVATGQLFTDALVEDSNIVQSKVVRSKQIDLKPMDLEEAILQMDLLGHDFFIYVDVED
                     QTTNVIYRREDGEIGLLEVKES"
     gene            6142..8115
                     /locus_tag="ACL8AS_001449"
     CDS             6142..8115
                     /locus_tag="ACL8AS_001449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HGS1229290.1"
                     /translation="MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVG
                     GYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTALLEQMPVGVMKLNLSSGEVEWFNP
                     YAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR
                     EQAITDELVTSRPVIGIVSVDNYDDLEDATSESDISQINSFVANFISEFSEKYMMFSR
                     RVSMDRFYLFTDYTVLEGLMNDKFSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIG
                     KVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRTRTRTRAMMTAISDKI
                     RSVDQVFVVGHKNLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFIEK
                     EGVTKLLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQTIVIDHHRRDQDFP
                     DNAVITYIESGASSASELVTELIQFQNSKKNRLSRMQASVLMAGMMLDTKNFTSRVTS
                     RTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGRKLGSDVLIAEAKDTKCY
                     DTVVISKAADAMLAMSGIEASFVLAKNIQGFISISARSRSKLNVQRIMEELGGGGHFN
                     LAAAQIKDVTLSEAGEKLTEIVLNEIKEKEKEE"
     gene            8112..8564
                     /gene="rplI"
                     /locus_tag="ACL8AS_001450"
     CDS             8112..8564
                     /gene="rplI"
                     /locus_tag="ACL8AS_001450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HGS1229291.1"
                     /translation="MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATAQAV
                     GELRGKQKSEEKAHAEMIAEGKAIKAQLEAEETVVEFVEKVGPDGRTFGSITNKKIAE
                     ELQKQFGIKIDKRHIQVQAPIRAVGLIDVPVKIYQDITSVINLRVKEG"
     gene            8607..9959
                     /gene="dnaB"
                     /locus_tag="ACL8AS_001451"
     CDS             8607..9959
                     /gene="dnaB"
                     /locus_tag="ACL8AS_001451"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HGS1229292.1"
                     /translation="MAEVEELRVQPQDILAEQSVLGAIFIDESKLVFVREYIESRDFF
                     KYAHRLIFQAMVDLSDRGDAIDATTVRTILDNQGDLQNIGGLSYLVEIVNSVPTSANA
                     EYYAKIVAEKAMLRRLIAKLTESVNQAYEASQPADEIIAQAEKGLIDVSENANRSGFK
                     NIRDVLNLNFGNLEARSQQTTDITGIATGYRDLDHMTTGLHEEELIILAARPAVGKTA
                     FALNIAQNIGTKLDKTVAIFSLEMGAESLVDRMLAAEGLVESHSIRTGQLTDEEWQKY
                     TIAQGNLANASIYIDDTPGIRITEIRSRSRKLAQETGNLGLILIDYLQLITGTGRENR
                     QQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIV
                     AFLYRDDYYERGGEEEEGIPNNKVEVIIEKNRSGARGTVELIFQKEYNKFSSISKREA
                     "
     gene            9961..10227
                     /locus_tag="ACL8AS_001452"
     CDS             9961..10227
                     /locus_tag="ACL8AS_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001278167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Veg family protein"
                     /protein_id="HGS1229293.1"
                     /translation="MSDAFTDVAKMKKIKEEIKAHEGQVVEMTLENGRKRQKNRLGKL
                     IEVYPSLFIVEFGDVEGDKQVNVYVESFTYSDILTEKNLIHYLD"
     gene            10316..11662
                     /gene="cbpD"
                     /locus_tag="ACL8AS_001453"
     CDS             10316..11662
                     /gene="cbpD"
                     /locus_tag="ACL8AS_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase CbpD"
                     /protein_id="HGS1229294.1"
                     /translation="MKILPFIARGTSYYLKMSVKKLVPFLVVGLMLAAGDSVYAYSRG
                     NGSIARGDDYPAYYKNGSQEIDQWRMYSRQCTSFVAFRLSNVNGFEIPAAYGNANEWG
                     HRARREGYRVDNTPTIGSITWSTAGTYGHVAWVSNVMGDQIEIEEYNYGYTESYNKRI
                     IKANTMTGFIHFKDLDGGSVGNSQSSTSTGGTHYFKTKSAIKTEPLVSATVIDYYYPG
                     EKVHYDQILEKDGYKWLSYTAYNGSYRYVQLEAVNKNPLGHSVLSSTGGTHYFKTKSA
                     IKTEPLVSGTVIDYYYPGEKVHYDQILEKDDYKWLSYTAYNGSRRYIQLEGVTSSQNY
                     QNQSGNISSYGSNNSSTVGWKKINGSWYHFKSNGSKSTGWLKDGSSWYYLKLSGEMQT
                     GWLKENGSWYYLGSSGAMKTGWYQVSGKWYYSYSSGALAVNTTVDGYRVNSDGERV"
     regulatory      11749..11848
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            11917..12207
                     /locus_tag="ACL8AS_001454"
     CDS             11917..12207
                     /locus_tag="ACL8AS_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MTH1187 family thiamine-binding protein"
                     /protein_id="HGS1229295.1"
                     /translation="MKASIALQVLPLAQGIDRIAVIDQVIAYLQTQEVTMVVTPFETV
                     LEGEFDELMRILKEALEVAGQEADNVFANVKINVGEILSIDEKLEKYTETTH"
     gene            12170..12928
                     /locus_tag="ACL8AS_001455"
     CDS             12170..12928
                     /locus_tag="ACL8AS_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009013602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229296.1"
                     /translation="MRNLKSILRRHISLLGFLGVLSIWQLAGFLKLLPKFILPTPLEI
                     LQPFVRDREFLWHHSWATLRVALLGLILGVLIACLMAVLMDSLTWFNDLIYPMMVVIQ
                     TIPTIAIAPILVLWLGYGILPKIVLIILTTTFPIIVSILDGFRHCDKDMLTLFSLMRA
                     NPWQILWHFKIPVSLPYFYAGLRVSVSYAFITTVVSEWLGGFEGLGVYMIQSKKLFQY
                     DTMFAIIILVSIISLLGMKLVDISEKYVIKWKRT"
     gene            12966..13973
                     /locus_tag="ACL8AS_001456"
     CDS             12966..13973
                     /locus_tag="ACL8AS_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HGS1229297.1"
                     /translation="MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFIL
                     DWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLPPEESSSDLVINGKAPFAVYFQDYMAK
                     KLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAMLKTLVE
                     SQGGDFEKVEKVPNNDSNSITPIANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYV
                     KEFDYYSPVIIANNDYLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKE
                     KRDFVIESQKYLSKEYASDKEKWGQFDAARWNAFYKWDKENGILKEDLTDKGFTNEFV
                     K"
     gene            13973..14701
                     /locus_tag="ACL8AS_001457"
     CDS             13973..14701
                     /locus_tag="ACL8AS_001457"
                     /EC_number="7.6.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229298.1"
                     /translation="MTEIRLEHVSYAYGQERILEDINLQVTSGEVVSILGPSGVGKTT
                     LFNLIAGILEVQSGRIVLDGEENPKGRVSYMLQKDLLLEHKTVLGNIILPLLIQKVDK
                     AEAISRADKILATFQLTAVRDKYPHELSGGMRQRVALLRTYLFGHKLFLLDEAFSALD
                     EMTKMELHAWYLEIHKQLQLTTLIITHSIEEALNLSDRIYILKNRPGQIVSEIKLDWS
                     EDEDKEVQKIAYKRQILAELGLDK"
     gene            14820..15278
                     /locus_tag="ACL8AS_001458"
     CDS             14820..15278
                     /locus_tag="ACL8AS_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HGS1229299.1"
                     /translation="MRFKNTSDHIEAYIKAILDQSGIVELQRSQLADTFQVVPSQINY
                     VIKTRFTESRGYLVESKRGGGGYIRIGRIEFSSHHEMLRELLYSIGERVSQEIYEDIL
                     QLLVEQKLMTKQEMNLLESVALDRVLGEEAPVVRANMLRQVIQEVDRKGK"
     gene            15280..17712
                     /locus_tag="ACL8AS_001459"
     CDS             15280..17712
                     /locus_tag="ACL8AS_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001109706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HGS1229300.1"
                     /translation="MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAG
                     ATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQVLFDEAEYVASVVHAKV
                     LGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
                     LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRM
                     IQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVSAEMAKMRVLELDLMNVVAG
                     TRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARG
                     TLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQ
                     ITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKYVKADDSDLSPADKAL
                     MDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEA
                     ELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVL
                     FDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVE
                     KAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDI
                     RFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAE
                     KGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSTLKI
                     GVKAGQLKFDIA"
     gene            18354..19007
                     /gene="rr06"
                     /locus_tag="ACL8AS_001460"
     CDS             18354..19007
                     /gene="rr06"
                     /locus_tag="ACL8AS_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001024075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RR06"
                     /protein_id="HGS1229301.1"
                     /translation="MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLP
                     IHLMVLDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDETTQSQVFDLYADDHVTKPF
                     SLVLLVKRIKALIRRYYVIEDIWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLI
                     QHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL"
     gene            19004..20344
                     /gene="hk06"
                     /locus_tag="ACL8AS_001461"
     CDS             19004..20344
                     /gene="hk06"
                     /locus_tag="ACL8AS_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     HK06"
                     /protein_id="HGS1229302.1"
                     /translation="MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGE
                     KFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDG
                     KLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFS
                     YFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGEVGKQINGMYEHLLKV
                     IHELESRNEQIVKLQNQKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIA
                     KSINKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIEN
                     QLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQE
                     LEHLFDIFYHSQIVTDKDESSGLGLYIVSNILESYQMDYSFLPYEHGMEFKISL"
     gene            20439..20966
                     /locus_tag="ACL8AS_001462"
     CDS             20439..20966
                     /locus_tag="ACL8AS_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenylcysteine carboxyl methyltransferase
                     family protein"
                     /protein_id="HGS1229303.1"
                     /translation="MVLAIILVTFLIRLIFLKRSIENEKRILSNGGKEFGVENTKRLT
                     LAHIVFYLSCLVEAMVHKTMFDGMSMVGLVLLIFSMLMLMLVIHLLGDIWTVKLMLVN
                     NHKYVDHILFRTVKHPNYFLNILPELIGLTLLSHAYVTFVLVFPVYAVILYRRIAEEE
                     KLLHEVIIPNGRMKG"
     gene            21046..>22664
                     /gene="pspC"
                     /locus_tag="ACL8AS_001463"
     CDS             21046..>22664
                     /gene="pspC"
                     /locus_tag="ACL8AS_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein PspC,
                     LPXTG-anchored form"
                     /protein_id="HGS1229304.1"
                     /translation="MFKSNYERKMCYSIRKFSIGVASVAVASLVMGSVVHATENEGTT
                     QAPTSSNRGNESQAEQRRELDLERDKVKKEVREYKEKKVKELYSKSTKSRHKKTVDIV
                     NKLQNINNEYLNKIIQSTSTYEELQKLMMESQSEVDKAVSEFEKDLSSSSSSGSSTEP
                     EASDTAKPNKPTELEKKVAEAQQKVEEAEKKAKDQKEEDYRNYPTITYKTLELEIAEF
                     DVKVKEAELELLKVKAKESRDEKKIKQAEAEVESKQAEATRLKKIKTDRKKAEEEAKL
                     KEAVEKNAATSEQGKPKRRVKRGALGEQATPDKKDYFEKDFRPAFNKNQQMVAIQESL
                     NKLDDETKTVPDGAKLTGEAGNAYNEVRDYAIKVVSENKKLLSQTAVTMDELAMQLTK
                     LNDAMSKLKEAKAKLVPEVKPQPENPEHQKPTTPAPDTKPIPQPEGKKPSVPDINQEK
                     EKAKLAVATYMSKILDDIQKHHLQKEKHRQIVALIKELDEFKKQALSEIDNVNTKVEI
                     ENTVHKIFADMDAVVTKFKKGLTQDTPKEPD"
BASE COUNT         7152 a         3769 c         5051 g         6692 t
ORIGIN      
        1 ttgttttttc cccagtctca ctcgattaga ataattaaaa caaaaaaccc tataataagg
       61 gctaagtgca tttaggagac tatacttcaa attcatagta aacgcgtcat aacaaggtat
      121 ctatcctaat tccccaactt ccagtatact agataaaaaa taattatcgg aggaaaggta
      181 ttgtactatg ataattcaac taagtgattt aggtcaagtt caccttgttt gtggcaagac
      241 agatatgagg cagggaatag actcattagc ctatgtagtt aaaacccact ttgaattgga
      301 tcctttctcc gatcaagtct ttctcttttg tggtggacgt aaagaccgct ttaaagtcct
      361 ttactgggat ggtcaaggat tttggatatt atataaacgc tttgagaacg gaaaactgac
      421 ttggtccagt acagaaaagg atgtcaaagc tctcacatct gaacaagtag actggcttat
      481 gaagggcttt tctatcactc cccaaatata gtggatttaa actagaatag tacacctctg
      541 cttctaaaac attgttagaa atcgatttga ctgtcctgtt cttatttcat tttactataa
      601 attcatcaga aagtcgtgat ttctattgaa atgaggactt tctttttata ctcatctgtt
      661 ttcaaaaagc attctattcc atctccgatt aacgatggac tttatcacct ccttctccag
      721 tccttgtata acatcttcca aagttcgaaa ggctttattc ttaaatccac gtttacgaat
      781 ctctttccac acttgttcaa tggggttcat ctctggtgtg tatggaggaa taaatgcaaa
      841 gccaatatta gtcggaatct ttaaggtact tgatttatgc catatagcat tgtccataac
      901 gagtaaaaga taatcatctg gataagcttg tgaaagctcc tattcctaaa gcccctttgg
      961 cgcatagctt tggatcggct tctattatcg ctcacaccat ccatcagaag tttaatctga
     1021 aggtacccaa ttatcgccaa gaagaagatt gggctaagat gggtttacca atcacacgca
     1081 aggaaatctc taattggcat atcaagacga gtcaatacta tttggaccct ctctataacc
     1141 tcttgcgaga gagactattg actcagccct tacttcatgc ggatgaaact tcttataggg
     1201 tgctagagag tgatagtcag ctgacttact attggacttt tttgtctggg aaagctgaga
     1261 aacaagggat tacgctttac catcatgtcc taatcgattt gttcatatct tatttcaatc
     1321 cattataaat agcgagaaat atctatccta tcttctagaa tgtcttccaa acgaggaaac
     1381 tctcgtaaac aaagaggttt tagaggctta tttaccatgg actaaagttg taccagaaaa
     1441 gtgcaaataa gaaatctcca gattaggaac tatccgtgag ttctctagtc tggagatttt
     1501 ttaatatact tcgttattgg acggttacaa ttcataaagt gctgtagaga gataacgttc
     1561 accgttatct ggtgctaggg caaggacttt tttacctgta cctaattttt tggcaacctc
     1621 gatggctccg tagatagctg cagctgagga aatccctaca aggaagcctt cttttccacc
     1681 aatttcacgt ccgagtgcaa gagcgttatc tgatgttaca cgaacgatac catcataggc
     1741 tttagtatca agtgtatcag gaataaatcc agctgagata ccttgaattt tgtgaggacc
     1801 gggtttttca ccagatagaa tagcagattc atctgcttct actgcaaaaa cttgaatgtt
     1861 agaattttct gatttgagtg catgagaaac accagaaatc gttccaccgg tacctactcc
     1921 agcaacaaag gcatctaatc catctttacc gaaagcagct agtatctcag ctcctgttgt
     1981 tctttcgtgt acttctggat tagctggatt gtcaaattga agaggaagga aaccatcacg
     2041 ttcagcagcg atttcttgag ccttagcaat agcacctttc attccctcgc taccaggagt
     2101 taggacgagt tcagcaccat aagcttggat aattttacgt cgttctacac tcatagtttc
     2161 aggcataacg atgacgactt tatacccttt agcagcacct acccatgaaa gtccaatacc
     2221 agtgtttcca cttgttgctt caacaatagt agaaccaggt ttcagaatac catcttgttc
     2281 agctttttca atcatgctaa gggcaatacg gtcttttaca gatgaaccag gattaaatgc
     2341 ttcaagcttt atatagacgt ctgcagcacc ttctggcacg atgttgttaa gtttaacaat
     2401 cggtgtttga ccgattaatt cagtaatgtt gttataaata gacatatgaa tacctctttg
     2461 tataagatat ctttagtata acgctatcca taccatttgt aaaatataga aatcctatcg
     2521 aagcgatagg atttctatat atcatagatc aaagtcatta attttcaagt gattgcgttc
     2581 agctaattct agtaaatagg tgtgaaggaa aacgatatca ggtttcgttt gaattgcttc
     2641 attttctagt atattttggt acgcatcttt ttattttgct cgctaaagta gttgtgagaa
     2701 tgtcaacgaa acgctgtatt attcattgtt tacactaagt ttacaggaac ttcaacctct
     2761 cgtaaacctt ggtcagttaa agtgactttt ccattaaaaa actccacaag tgcagcttta
     2821 atagtttctt tttcttcttt atcaacataa atcatcgtat cgacttgatc tgtaaagttt
     2881 gtatccagct ccatgagatc atgttcttta aggaagttac tgtactcttg gtactgagca
     2941 taagacattt gaatagcaat gccagcctgt tcttttattt caataatacc aatttctttg
     3001 acagctaagg cgacactgcc ggcgtaagca cgaattagtc ctccagcgcc tagtttaata
     3061 ccaccaaagt agcgtgtcac gaccacacag acattggtga gattgtgatt ttctagtacc
     3121 ccaagcatgg gaacaccagc agtaccacta ggctcaccat catcacttgt acgtttaatt
     3181 tcactacgtt ctccaataat aaaggcagag cagttatgtg tcgctttgta gtgttctttt
     3241 ttgatggcag taatgaagtc acgagcctct tcttcgctat aaacacgctt ggcatggcag
     3301 ataaagcgag attttttgat ttcttcttgg acttggccgt cctctttaat tgtcctaaat
     3361 tccatgattt aattgtacta aaaaataatc taaagtgcta gtttttacga ataaagaagt
     3421 atgaaagtaa atttagatta tctcggtcgt ttatttactg agaatgaatt aacagaagaa
     3481 gaacgtcagt tggcggagaa acttccagca atgagaaagg agaaggggaa acttttctgt
     3541 caacgctgta atagtactat tctagaagaa tggtatttgc ccatcggtgc ttactattgt
     3601 cgagagtgct tgctgatgaa gcgagtcaga agtgatcaaa ctttatacta ttttccgcag
     3661 gaggattttc cgaagcaaga tgttctcaaa tggcgcggcc aattaactcc ttttcaagag
     3721 aaggtgtcag agggattgct tcaagcagta gacaagcaaa agccaacctt agttcatgcg
     3781 gtaacaggag ctggaaagac agaaatgatt tatcaagtag tggctaaagt gatcaatgcg
     3841 ggtggtgcag tgtgtttggc tagtcctcgc atagatgttt gtttggagct gtacaagcgc
     3901 ctgcaacagg atttttcttg cggtatagct ttgctacatg gagaatcgga accttatttt
     3961 cgaacaccac tagttgttgc aacaacccat cagttattga agttttatca agcttttgat
     4021 ttgctgatag tggatgaagt agatgctttt ccttatgttg ataatcccac gctttaccac
     4081 gctgtcaaga atagtgtaaa ggagaatgga ttgagaatct ttttaacagc gacttcgacc
     4141 aatgagttag ataaaaaggt ccgtttagga gaactaaaaa gactgagttt accgagacgg
     4201 tttcatggaa atccgttgat tattccaaaa ccaatttggt tatcggattt taatcgctac
     4261 ttagacaaga atcgtttgtc accaaagtta aagtcctata ttgagaagca gagaaagaca
     4321 gcttatccgt tactcatttt tgcttcagaa attaagaaag gggagcagtt agaagaaatc
     4381 ttacaggagc aatttccaaa tgagaaaatt ggctttgtat cttctgtaac agaggatcga
     4441 ttagagcaag tacaagcttt tcgagatgga gaactgacaa tacttatcag tacgacaatc
     4501 ttggagcgtg gagttacctt cccttgtgtg gatgttttcg tagtagaggc caatcatcgt
     4561 ttgtttacca agtctagttt gattcagatt ggtggacgag ttggacgaag catggataga
     4621 ccgacaggag atttgctttt cttccatgat gggttaaatg cttcaatcaa gaaggcgatt
     4681 aaggaaattc agatgatgaa taaggaggct ggtctatgaa gtgcttgtta tgtgggcaga
     4741 ctatgaagac tgttttaact tttagtagtc tcttacttct gaggaataat gactcttgtc
     4801 tttgttcaga ctgtgattct acttttgaaa gaattgggga agagaactgt ccaaattgta
     4861 tgaaaacaga gttgtcaaca aagtgtcaag attgtcaact ttggtgtaaa gaaggagttg
     4921 aagtcagtca tagagcgatt tttacttaca atcaagctat gaaggatttt ttcagtcggt
     4981 ataagtttga tggagacttc ctgttaagaa aagttttcgc ttcattttta agtgaggagt
     5041 tgaaaaagta caaagagtat caatttgttg taattcccct aagtcctgat agatatgcta
     5101 atagaggatt taatcaggtt gagggcttgg tagaggcagc aggctttgag tatctggatt
     5161 tattagagaa aagagaagag agagccagtt cttctaaaaa tcgttcagag cgcttgggga
     5221 cagaacttcc tttctttatt aaaagtggag tcactattcc taaaaaaatc ctacttatag
     5281 atgatatcta tactacagga gcaactataa atcgtgttaa gaaactgttg gaagaagctg
     5341 gtgctaagga tgtaaaaaca ttttcccttg taagatgagg aaaaaatttg caaaaataga
     5401 atgaaagcgt tataataaaa tcataaaaac aaaaatgttt agaaagaagg tactcatatg
     5461 attaaatata gtatccgtgg tgaaaaccta gaagtaacag aagcaattcg tgattatgta
     5521 gtttctaaac tcgaaaagat cgaaaagtac ttccaaccag aacaagagtt ggatgcccga
     5581 attaacttaa aagtttatcg tgaaaaaacg gctaaagtgg aagtaacgat tccgcttgga
     5641 tctattactc tccgcgcaga agatgtatct caagatatgt atggttcaat tgaccttgta
     5701 actgataaaa ttgaacgtca gattcgtaaa aataaaacaa aaatcgagcg taaaaataaa
     5761 aataaggtag caactggtca attatttaca gatgctttgg tggaagattc aaatattgtc
     5821 cagtctaaag ttgttcgttc aaaacaaatt gatttaaaac caatggattt ggaagaagca
     5881 attctacaaa tggatttatt ggggcatgat ttctttatct atgtggatgt tgaagatcag
     5941 acaaccaatg tgatttatcg tcgtgaggat ggcgaaattg gtttgttaga ggttaaagaa
     6001 tcttaatttc aatatgtgta aaggtaggtt tactgaattg taaactacct ttttcttata
     6061 attgatagaa ttactgatta cacttttaaa aagtcgcttt ttgaggggta ttatggtata
     6121 atgggtgcca agaggttttg aatgaaaaaa ttttatgtaa gtccaatttt tcctattcta
     6181 gtaggattga ttgcgtttgg agtcttatcc actttcatta tttttgttaa taataatctg
     6241 ttgacggttt taattttgtt tctttttgta ggaggctatg tttttttatt taagaaactg
     6301 agagtgcatt atacaaggag tgatgtagaa cagatacagt atgtaaacca ccaagcggaa
     6361 gaaagtttga cagctctatt ggaacagatg cctgtaggtg ttatgaaatt gaatttatct
     6421 tctggagagg ttgagtggtt taatccctat gctgaattga ttttgaccaa ggaagatggt
     6481 gattttgatt tagaagctgt tcaaacgatt atcaaggctt cagtaggaaa tccgtctact
     6541 tatgccaagc ttggtgagaa gcgttatgct gttcatatgg atgcttcttc cggtgttttg
     6601 tattttgtag atgtatccag ggaacaagcc ataacagatg aattggtaac aagtcgacca
     6661 gtgattggga ttgtctctgt ggataattat gatgatttgg aggatgcaac ttctgagtca
     6721 gatattagtc aaatcaatag ttttgtagct aattttatat cagagttttc agaaaaatac
     6781 atgatgtttt ctcgtcgggt aagtatggat cgattttatc tatttactga ctacacggtg
     6841 cttgagggct tgatgaatga taaattttct gttattgatg ctttcagaga agagtcgaaa
     6901 cagagacagt tgcccttgac cttaagtatg ggattttctt atggcgatgg aaatcatgat
     6961 gagataggga aagttgcttt gctcaatttg aacttggctg aagtacgtgg tggcgaccag
     7021 gtggttgtta aggaaaacga cgaaacgaaa aatccagttt attttggtgg tgggtctgct
     7081 gcttcaatca agcgtacacg gactcgtacg cgcgctatga tgacagctat ttcagataag
     7141 attcggagtg tagatcaggt ttttgtagtc ggtcacaaaa atttagacat ggatgctttg
     7201 ggctctgctg taggtatgca gttgttcgcc agcaatgtga ttgaaaatag ctatgctctt
     7261 tatgatgaag aacaaatgtc tccagatatt gaacgagctg tttcattcat agaaaaagaa
     7321 ggagttacga agttgttgtc tgttaaggat gcaatgggga tggtgaccaa tcgttctttg
     7381 ttgattcttg tagaccattc aaagacagcc ttaacattat caaaagaatt ttatgattta
     7441 tttacccaaa ccattgttat tgaccaccat agaagggatc aggattttcc agataatgca
     7501 gtcattactt atatcgaaag tggtgcaagt agtgccagtg agttggtaac ggaattgatt
     7561 cagttccaga attctaagaa aaatcgtttg agtcgtatgc aagcaagtgt tttgatggct
     7621 ggtatgatgt tggatactaa aaatttcacc tcgcgagtaa ctagtcggac atttgatgtt
     7681 gctagctatc tcagaacgcg cggaagtgat agtattgcta tccaggaaat cgctgcgaca
     7741 gattttgaag aatatcgtga ggtcaatgaa cttattttac aggggcgtaa attaggttca
     7801 gatgtactaa tagcagaggc taaggacacg aaatgctatg atacagttgt tattagtaag
     7861 gcagcagatg ccatgttagc catgtcaggt attgaagcga gttttgttct tgcgaagaat
     7921 atacaaggat ttatctctat ctcagctcga agtcgtagta aactgaatgt acaacggatt
     7981 atggaagagt taggcggtgg aggccacttt aatttggcag cagctcaaat taaagatgta
     8041 accttgtcag aagcaggtga aaaactgaca gaaattgtat taaatgaaat aaaggaaaag
     8101 gagaaagaag aatgaaagta atctttttag cagatgttaa aggaaaaggt aaaaaaggcg
     8161 aaattaagga agtaccaaca gggtatgcgc aaaattttct tatcaaaaag aatctagcca
     8221 aagaagcgac tgctcaagct gtaggtgaac ttcgtggtaa acaaaaatcg gaagaaaaag
     8281 ctcacgctga gatgattgca gaaggaaaag caattaaagc acaacttgaa gcagaagaaa
     8341 ctgttgtaga atttgttgaa aaagttggtc cagatggtcg tacctttggt tctattacca
     8401 ataagaagat tgcagaagaa ttgcaaaagc aatttggaat taagattgat aaacgtcata
     8461 ttcaagtaca agctccgatt cgagcggttg gtttgattga tgtgccagtg aaaatctatc
     8521 aagatatcac aagtgtaatc aatcttcgtg tgaaagaagg ataagtttac actttcttga
     8581 caagattgta aaagaaggga agtctgatgg cagaagtaga agagttacga gtacaacctc
     8641 aagatatctt agctgagcaa tccgttttag gggctatctt tattgatgag agtaaacttg
     8701 tttttgtgcg agaatacatt gagtctcggg acttttttaa gtatgcccat cgtttgattt
     8761 tccaagccat ggtcgattta tccgatcgtg gtgatgccat agatgcaaca acggttcgta
     8821 ctatccttga taatcaaggt gatttacaga atattggtgg cttgtcttac ttggttgaga
     8881 ttgttaattc tgtgccaact tctgctaatg cggagtatta tgctaagatt gttgcagaaa
     8941 aagcaatgct acgtcgttta attgccaagt tgacagagtc tgtcaaccaa gcttacgaag
     9001 cgtcacaacc agctgatgaa attattgctc aggcagaaaa agggttgatt gatgtcagtg
     9061 aaaatgcaaa tcgaagcggg tttaagaaca ttcgagatgt gttgaatctc aactttggaa
     9121 atctggaagc tcgctcgcaa caaacgaccg atattacagg tattgcgaca ggttatcgtg
     9181 atttggatca tatgacaaca ggacttcatg aggaggagtt gattatctta gcagctcgtc
     9241 cagcagttgg taagacagca tttgccttga atatcgctca gaacattggg actaagttgg
     9301 acaaaacggt tgctattttt tcactcgaaa tgggtgcgga aagcttggta gatcgtatgt
     9361 tagctgcaga aggcttagtg gagtcacatt ctatccgtac agggcaattg acagatgagg
     9421 agtggcaaaa atatactatt gctcagggta atctagctaa cgccagtatc tatatcgatg
     9481 atacgccagg tattcggatt acagagattc gttctcgttc tcgtaaattg gctcaagaaa
     9541 ctggaaatct tggtttgatt ttgatagact atttgcaact tatcacggga actggtcgag
     9601 aaaatcgtca acaagaagtt tctgaaattt ctcgtcagtt gaaaatacta gccaaggaat
     9661 tgaaggttcc agtaatcgct ctgagtcagc tttctcgtgg tgtagaacaa cgtcaggaca
     9721 agagaccggt cttgtctgat attcgtgaat ctgggtctat tgagcaggac gctgatatcg
     9781 tagcttttct ctatcgcgat gactactatg aacgtggtgg tgaagaagag gagggtatcc
     9841 caaataataa ggtggaagtt attatcgaga aaaaccgtag tggagctcgt ggaacagtgg
     9901 aattgatttt ccaaaaagaa tacaataaat tttcaagtat ctcaaagagg gaggcataag
     9961 atgtcagatg catttacaga tgtagccaag atgaaaaaaa tcaaagaaga aatcaaggca
    10021 catgagggac aagtcgtaga aatgactttg gagaatggtc gtaagcgcca aaaaaataga
    10081 ttgggtaagc taattgaagt ttatccatct ctatttattg tggagtttgg ggatgtggaa
    10141 ggagataaac aagttaatgt ttacgttgaa tcctttactt actcagatat tcttacagaa
    10201 aagaatttga ttcattatct tgactaaagt gagaaatttt ctcacttttt cttttttctc
    10261 cgaataattt aggtgaaggc aatcatcgct ttatattatt tttcaaggag gaagaatgaa
    10321 aattttaccg tttatagcaa gaggaacaag ttattacttg aagatgtcag ttaaaaagct
    10381 tgttcctttt ttagtagtag gattgatgct agcagctggt gatagtgtct atgcctattc
    10441 cagaggaaat ggatcgattg cgcgtgggga tgattatcct gcttattata aaaatgggag
    10501 ccaggagatt gatcagtggc gcatgtattc tcgtcagtgt acttcttttg tagcctttcg
    10561 tttgagtaat gtcaatggtt ttgaaattcc ggcagcttat ggaaatgcga atgaatgggg
    10621 acatcgtgct cgtcgggaag gttatcgtgt agataataca ccgacgattg gttccattac
    10681 ttggtctact gcaggaactt atggtcatgt tgcctgggtg tcaaatgtaa tgggagatca
    10741 gattgagatt gaggaatata actatggtta tacagaatcc tataataaac gaattataaa
    10801 agcaaacacg atgacaggat ttattcattt taaagatttg gatggtggca gtgttgggaa
    10861 tagtcaatcc tcaacttcaa caggcggaac tcattatttt aagaccaagt ctgctatcaa
    10921 aactgaaccc ctagttagtg caactgtgat tgattactat tatcctggag agaaggttca
    10981 ttatgatcaa attctcgaaa aagacggcta caagtggttg agttatactg cctataatgg
    11041 aagctatcgt tatgttcaat tggaggctgt gaataaaaat cctctaggtc attctgttct
    11101 ttcttcaaca ggtggaactc attattttaa gaccaagtct gctatcaaaa ctgaacccct
    11161 agttagcgga actgtgattg attactatta tcctggggag aaggttcatt atgatcagat
    11221 acttgaaaaa gacgactata agtggttgag ttatacggct tataacggaa gtcgtcgcta
    11281 tatacagcta gagggagtga cttcttcaca aaattatcag aatcaatcag gaaatatctc
    11341 tagctatgga tccaataata gttcaactgt cggttggaag aaaataaatg gtagttggta
    11401 tcatttcaaa tcaaatggtt ctaaatcaac aggatggctg aaagacggtt ctagctggta
    11461 ttatttgaaa ttatctggtg aaatgcagac aggatggtta aaggagaatg gctcgtggta
    11521 ttatctgggt agttcagggg caatgaaaac aggctggtac caggtctctg gtaagtggta
    11581 ttattcttac tcttcaggcg ccttagctgt taatacgacg gtggatggct acagagtaaa
    11641 cagtgatgga gaacgagtat agaaaattgg agtaggagaa atttcctgct cttttctgta
    11701 agcagtttcc ttgacatttt tcttattttg cgctatcata tatacataca atatatagga
    11761 gtctgtgtac agtctgagag gaagtgttaa acttcgaccg cacctgatct gggtaatgcc
    11821 agcggaggga acgatactta gtctaatttt gcaccttttc catgtatggt aaaggttttt
    11881 ctttttttaa aaggaaaacg agaagaggag gttcttatga aagcaagcat tgccttgcaa
    11941 gttttacccc tagcacaggg gattgatcgg atagctgtta ttgatcaggt cattgcttat
    12001 ctgcaaactc aagaagtgac gatggtagtg acaccatttg aaacggtctt ggaaggggag
    12061 tttgatgagc ttatgcgcat tctaaaagaa gcgctggaag tggcagggca ggaggcagac
    12121 aatgtctttg ccaatgtcaa aataaatgta ggagagattt taagtattga tgagaaactt
    12181 gaaaagtata ctgagacgac acattagtct attgggcttt ctcggagtat tgtcaatctg
    12241 gcagttagca ggttttctta aacttctccc caagtttatc ctgccgacac ctcttgaaat
    12301 tctccagccc tttgttcgtg acagagaatt tctctggcac catagctggg cgaccttgag
    12361 agtggcttta ctggggctga ttttgggagt tttgattgcc tgtcttatgg ctgtgctcat
    12421 ggatagtttg acttggttca atgacctgat ttaccctatg atggtggtca ttcagaccat
    12481 tccgaccatt gccatagctc ctatcctggt cttgtggcta ggttatggga ttttgcccaa
    12541 gattgtcttg attatcttaa caacaacctt tcccatcatc gttagtattt tggacggttt
    12601 taggcattgt gacaaggata tgctgacctt gtttagtctg atgcgagcaa acccttggca
    12661 aatcctgtgg cattttaaaa tcccggttag cctgccttac ttttatgcag gtctgagggt
    12721 cagtgtctcc tacgccttta tcacaactgt ggtatctgag tggttgggag gttttgaagg
    12781 tcttggtgtt tatatgattc agtctaaaaa actgtttcag tatgatacca tgtttgccat
    12841 tattattctg gtgtcgatta tcagtctttt gggtatgaag ctggtcgata tcagtgaaaa
    12901 atatgtgatt aaatggaaac gtacttaaaa tagagcgttt ttgaaaaaga aaagaggaaa
    12961 tcaaaatgaa gaaaacatgg aaagtgtttt taacgcttgt aacagctctt gtagctgttg
    13021 tgcttgtggc ctgtggtcaa ggaactgctt ctaaagacaa caaagaggca gaacttaaga
    13081 aggttgactt tatcctagac tggacaccaa ataccaacca cacagggctt tatgttgcca
    13141 aggaaaaagg ttatttcaaa gaagctggag tggatgttga tttgaaattg ccaccagaag
    13201 aaagttcttc tgacttggtt atcaacggaa aggcaccatt tgcagtgtat ttccaagact
    13261 acatggctaa gaaattggaa aaaggagcag gaatcactgc cgttgcagct attgttgaac
    13321 acaatacatc aggaatcatc tctcgtaaat ctgataatgt aagcagtcca aaagacttgg
    13381 ttggtaagaa atatgggaca tggaatgacc caactgaact tgctatgttg aaaaccttgg
    13441 tagaatctca aggtggagac tttgagaagg ttgaaaaagt accaaataac gactcaaact
    13501 caatcacacc gattgccaat ggcgtctttg atactgcttg gatttactac ggttgggatg
    13561 gtatccttgc taaatctcaa ggtgtagatg ctaacttcat gtacttgaaa gactatgtca
    13621 aggagtttga ctactattca ccagttatca tcgcaaacaa cgactatctg aaagataaca
    13681 aagaagaagc tcgcaaagtc atccaagcca tcaaaaaagg ctaccaatat gccatggaac
    13741 atccagaaga agctgcagat attctcatca agaatgcacc tgaactcaag gaaaaacgtg
    13801 actttgtcat cgaatctcaa aaatacttgt caaaagaata cgcaagcgac aaggaaaaat
    13861 ggggtcaatt tgacgcagct cgctggaatg ctttctacaa atgggataaa gaaaatggta
    13921 tccttaaaga agacttgaca gacaaaggct tcaccaacga atttgtgaaa taatgacaga
    13981 aattagacta gagcacgtca gttatgccta tggtcaggag aggattttag aggatatcaa
    14041 cctacaggtg acttcaggcg aagtggtttc catcctaggc ccaagtggtg ttggaaagac
    14101 caccctcttt aatctaatcg ctgggatttt agaagttcag tcagggagaa ttgtccttga
    14161 tggtgaagaa aatcccaagg ggcgcgtgag ttatatgttg caaaaggatc tgctcttgga
    14221 gcacaagacg gtgcttggaa atatcattct gcccctcttg attcaaaagg tggataaggc
    14281 agaagctatt tcccgagcgg ataaaattct tgcgaccttc cagctgacag ctgtaagaga
    14341 caagtatcct catgaactta gcggtgggat gcgccagcgt gtagccttac tccggaccta
    14401 cctttttggg cacaagctct ttctcttaga tgaggccttt agcgccttgg atgagatgac
    14461 aaagatggaa ctccacgctt ggtatcttga gattcacaaa cagttgcagc taacaaccct
    14521 gatcatcacg catagtattg aggaggccct caatctcagc gaccgcatct atatcttgaa
    14581 aaatcgccct gggcagattg tttcagaaat taaactagat tggtctgaag atgaggacaa
    14641 ggaagtccaa aagattgcct acaaacgtca aatcttggca gaattaggct tagataagta
    14701 gaaaaatagg gagttggtga agattatcct ttaccagcgc cctttttctt ttaaaaatga
    14761 gaaaatttcg gtataatagt caaacaaggt caaggtttaa agagagaggt gggtttgtta
    14821 tgagatttaa aaatacatcg gatcatattg aggcctacat caaggcgatt ttagatcaat
    14881 ctggtatcgt ggagttgcaa cggagtcagt tggcagatac ctttcaggtt gttcctagtc
    14941 agattaacta cgtgatcaag acacgcttta cggaaagtag aggctacttg gttgaaagta
    15001 agcgtggtgg cggaggctac attcgtatag gacggattga gttttctagt catcatgaaa
    15061 tgctccggga gctgctttac tcgattggtg agcgagtcag tcaagaaatt tatgaggata
    15121 ttctccagct tttggttgag cagaaattga tgaccaagca ggagatgaat ttgctagaat
    15181 cagtagcttt ggatcgcgtt ttaggagaag aagctccagt tgttcgagca aacatgctac
    15241 gtcaggtcat acaagaggta gatagaaaag ggaagtaaga tgaactattc aaaagcattg
    15301 aatgaatgta tcgaaagtgc ctacatggtt gctggacatt ttggagctcg ttatctagag
    15361 tcttggcact tgttgattgc catgtctaat cacagttata gtgtagcagg ggcaacttta
    15421 aatgattatc cgtatgagat ggaccgttta gaagaggtgg ctttggaact gactgaaacg
    15481 gactatagcc aggatgaaac ctttacggaa ttgccgttct cccgtcgttt gcaggttctt
    15541 tttgatgaag cagagtatgt agcgtcagtg gtccatgcta aggtactagg gacagagcac
    15601 gtcctctatg cgattttgca tgatggcaat gccttggcga ctcgtatctt ggagagggct
    15661 ggtttttctt atgaagacaa gaaagatcag gtcaagattg ctgcccttcg tcgaaattta
    15721 gaagaacgtg caggctggac tcgtgaagat ctcaaggctt tacgccaacg ccatcgtaca
    15781 gtagctgaca agcaaaattc tatggccaat atgatgggca tgccgcagac tcctagtggt
    15841 ggtctcgagg actatacgca tgatttgaca gagcaagcgc gttctggcaa gttagaacca
    15901 gtcatcggtc gggacaagga aatctcacgt atgattcaaa tcttgagccg taagactaag
    15961 aacaaccctg tcttggttgg ggatgctggt gtcgggaaaa cagctctggc gcttggtctt
    16021 gctcagcgta ttgctagtgg tgacgtgtct gcggaaatgg ctaagatgcg cgtgttagaa
    16081 cttgatttga tgaatgtcgt tgcagggaca cgcttccgtg gtgactttga agaacgcatg
    16141 aataatatca tcaaggatat tgaagaagat ggccaagtca tcctctttat cgatgaactc
    16201 cacaccatca tgggttctgg tagcggaatt gattcgactc tggatgcggc caatatcttg
    16261 aaaccagcct tggcgcgtgg aactttgaga acggttggtg ccaccactca ggaagaatat
    16321 caaaaacata tcgaaaaaga tgcggctctt tctcgtcgtt tcgctaaagt gacgattgaa
    16381 gaaccaagtg tggcagatag tatgactatt ttacaaggtt tgaaggcgac ttatgagaaa
    16441 catcaccgtg tacaaatcac agatgaagcg gttgaaacag cggttaagat ggctcatcgt
    16501 tatttaacca gtcgtcactt gccagactct gctatcgacc tcttggacga agcagcagca
    16561 acagtgcaaa ataaggcaaa gtatgtaaaa gcagacgatt cagatttgag tccagctgac
    16621 aaggccctga tggatggcaa gtggaaacag gcagcccagc taatcgcaaa agaagaggaa
    16681 gtacctgtct acaaagactt ggtgacagag tctgatattt tgaccacctt gagtcgcttg
    16741 tcaggaatcc cagttcaaaa actgactcag actgacgcta agaaatatct aaatcttgaa
    16801 gcagaactcc ataaacgggt tatcggtcaa gatcaagctg tttcaagtat tagtcgtgcg
    16861 attcgccgta atcagtcagg aattcgcagt cacaagcgtc cgatcggttc ctttatgttc
    16921 ctaggaccca caggtgtcgg taagaccgag ttggccaagg ctttggcaga agttctcttt
    16981 gatgacgaat cagcccttat ccgctttgat atgagtgagt atatggagaa attcgcagcc
    17041 agccgtctaa atggagctcc tccaggctat gtgggttacg aagaaggtgg ggagttgaca
    17101 gagaaggttc gcaataaacc ctattccgtt ctcctctttg atgaggtaga gaaggctcac
    17161 ccagatatct ttaatgttct cttgcaggtt ctggatgacg gtgtcttgac agatagcaag
    17221 ggacgcaagg tcgatttttc aaataccatt atcattatga catcgaacct aggtgcgact
    17281 gcccttcgtg atgataagac tgttggtttt ggggctaagg atattcgttt tgaccaggaa
    17341 aatatggaaa aacgcatgtt tgaagaactg aaaaaagctt atagaccgga attcatcaac
    17401 cgtattgatg agaaggtggt cttccatagc ctatctagtg accatatgca ggaagtggtg
    17461 aagattatgg tcaagccttt agtggcaagt ttggctgaaa aaggcattga cttgaaatta
    17521 caagcttcag ctctgaaatt gttagcaaat caaggatatg acccagagat gggagctcgc
    17581 ccacttcgca gaaccctgca aacagaagtg gaggacaagt tggcagaact tcttctcaag
    17641 ggagatttag tggcaggcag cacacttaag attggtgtca aagcaggcca gttaaaattt
    17701 gatattgcat aaaagaataa aagtaccagc atctgaccat aagtcacagt ggagtgaaac
    17761 tcaatgaaaa tcaaagagca aactaggcag ctagccgcag gttgctcaaa acactggttt
    17821 gaggttgcag atagagctga cgtggtttga agagattttc gaagagtatg aaactaaaac
    17881 ctatagcttc taaacgattc gtggttttca ccattcaaca caaaattcat atgtttatta
    17941 ccctccgtcg tatttgtctt agagcgtgtg tagtagaaaa agagcagtct tatctgaaat
    18001 ttttattctt tcaaaagaga cctgtttctt ttttgcatgt caaatccgtt ctagctggta
    18061 tttgaaaaat caaactaata ttcaatgaaa atcaaagagc aaactaggta gctagccgca
    18121 ggttgctcaa aacactgttt tgaggttgta gatagagcta acgtggtttg aagagatttt
    18181 cgaagagtat aagctgcaag atgaatgatt ttcttgtatt gacgttgttg ttgacaaaaa
    18241 gtagcggata aatgaaatcc attccattat catagatgat aggctggtag gaaattttca
    18301 aatagcatac aggaaataga tgtatggagt tctggtagta gaaagggaga gagatgaaca
    18361 ttttagttgc agatgacgag gaaatgatta gagaaggaat tgcagcattt ctgacagaag
    18421 agggttatca tgtcattatg gctaaggatg gacaagaggt cttggaaaaa tttcaagatc
    18481 tccctatcca tctcatggta ctggatttaa tgatgcctag gaagagtggt tttgaagtgt
    18541 taaaagaaat caatcaaaag cacgatattc ctgtcatcgt cttgagtgct ctgggagatg
    18601 aaactactca gtcacaggta tttgatctct atgctgatga tcatgtgaca aaaccttttt
    18661 ctttggtact gcttgtcaag cgtattaagg cgcttatcag acgttactac gtcatagagg
    18721 atatttggcg atatcaggat gtaacagtgg attttacctc ttacaaagca cattataaaa
    18781 atgaagaaat tgatctcaaa ccaaaggaat tactggtact aaagtgtttg attcagcata
    18841 aaaatcaagt tttaagtaga gagcagatat tggaagaaat ttcaaaagat gtagctgatt
    18901 taccttgtga tagggtcgtt gatgtctata ttcgtactct tcgcaaaaaa ttagctttag
    18961 attgtatcgt gactgtgaaa aatgttgggt ataagattag cttatgataa aaaatcctaa
    19021 attattaacc aagtcttttt taagaagttt tgcaattcta ggtggtgttg gtctagtcat
    19081 tcatatagct atttatttga cctttccttt ttattatatt caactggagg gggaaaagtt
    19141 taatgagagc gcaagagtgt ttacggagta tttaaagact aagacatctg atgaaattcc
    19201 aagcttactc cagtcttatt caaagtcctt gaccatatct gctcacctta aaagagatat
    19261 tgtagataag cggctccctc ttgtgcatga cttggatatt aaagatggaa agctatcaaa
    19321 ttatatcgtg atgttagata tgtctgttag tacagcagat ggtaaacagg taaccgtgca
    19381 atttgttcac ggggtagatg tctacaaaga agcaaagaat attttgcttt tgtatctccc
    19441 atatacattt ttggttacaa ttgctttttc ctttgttttt tcttattttt atactaaacg
    19501 cttgctcaat cctctttttt acatttcaga agtgactagt aaaatgcaag atttggatga
    19561 caatattcgt tttgatgaaa gtaggaaaga tgaagttggt gaagttggtg aagttggaaa
    19621 acagattaat ggtatgtatg agcacttgtt gaaggttatt catgagttgg aaagtcgtaa
    19681 tgagcaaatt gtaaaattgc aaaatcaaaa ggtttccttt gtccgcggag catcacatga
    19741 gttgaaaacc cctttagcca gtcttagaat tatcctagag aatatgcagc ataatattgg
    19801 agattacaaa gatcatccaa aatatattgc aaagagtata aataagattg accagatgag
    19861 ccacttattg gaagaagtac tggagtcttc taaattccaa gagtggacag agtgtcgtga
    19921 gaccttgact gttaagccag ttttagtaga tattttatca cgttatcaag aattagctca
    19981 ttcaataggt gttacaattg aaaatcaatt gacagatgct actagggtcg tcatgagtct
    20041 tagggcattg gataaggttt tgacaaacct gattagtaat gcaattaaat attcagataa
    20101 aaatgggcgt gtaatcatat ccgagcaaga tggctatctc tctatcaaaa atacatgtgc
    20161 gcctctaagt gaccaagaac tagaacattt atttgatata ttctatcatt ctcaaatcgt
    20221 gacagataag gatgaaagtt ccggtttggg tctttacatt gtgagtaata ttttagaaag
    20281 ctatcaaatg gactatagtt ttctccctta tgaacacggt atggaattta agattagctt
    20341 gtagacagat tagtttttta ttaaagttca catagggtta acataagtgt attattcttt
    20401 atatagataa aaatatagat aaaagaaagg atactaatat ggtattagcg attattttag
    20461 taacattcct tattcgattg atttttttaa agcgttcgat agagaatgag aaacgaatcc
    20521 ttagcaatgg cgggaaagaa tttggagttg agaatacaaa acgattaacg ttggctcata
    20581 ttgtttttta tctctcttgc ctcgttgaag caatggtgca taagacaatg tttgatggta
    20641 tgagcatggt tggtttagtc ttgcttattt tttctatgct gatgttgatg ttggtgattc
    20701 acttgttggg agatatttgg acagtgaagc ttatgcttgt caataatcac aaatatgtag
    20761 atcatatctt gtttaggaca gtaaaacatc ctaattactt tttaaatatt cttcctgagt
    20821 tgattggctt gaccttgttg agtcatgctt atgtgacttt tgttttagtt tttccagttt
    20881 atgcagttat tttgtatcga cgaatagctg aagaggaaaa gctattacat gaagttataa
    20941 tcccaaatgg aagaatgaaa ggttaaaaat aaaataccca atttaatata cagttcatat
    21001 tggaagggta tactgaagat gaataaaata ttataggata tcgatatgtt taaatcaaat
    21061 tatgaaagaa aaatgtgcta ttctattcga aaatttagta taggagtagc tagtgtagct
    21121 gttgccagtc ttgttatggg aagtgtggtt catgcgacag agaacgaggg aactacccaa
    21181 gcacccactt cttctaatag gggaaatgaa agtcaggcag aacaacgtag agaactcgat
    21241 ttagaacgag ataaggtaaa gaaagaggtc agggaatata aagaaaaaaa agtgaaagag
    21301 ctctattcaa aatcaactaa aagtcgacat aagaagactg tagatatagt taacaagttg
    21361 caaaacatta ataacgagta tttgaataaa ataattcaat caacctcaac atacgaagaa
    21421 ctacagaaac tgatgatgga gagtcaatca gaagtagata aagctgtgtc tgaatttgaa
    21481 aaggacttat cttcttcgtc aagttcaggc tcttccacgg aaccggaagc ttcagataca
    21541 gcgaagccaa acaagccgac agaactagaa aaaaaggtag cagaagctca gcagaaggtt
    21601 gaagaagctg agaaaaaagc caaggatcaa aaagaagaag attaccgtaa ctacccaacc
    21661 attacttaca aaacgcttga acttgaaatt gctgagttcg atgtgaaagt taaagaagcg
    21721 gagcttgaac tattaaaagt gaaagctaag gaatctcgag acgagaaaaa aattaagcaa
    21781 gcagaagcgg aagttgagag taaacaagct gaggctacaa ggttaaaaaa aatcaagaca
    21841 gatcgtaaaa aagcagaaga agaagctaag ttgaaggaag ctgttgaaaa gaatgcagcg
    21901 acttcagagc aaggtaaacc aaagaggcgg gtaaaacgag gagctcttgg agagcaagca
    21961 acacctgata aaaaagatta ttttgaaaaa gacttccgtc cagctttcaa taaaaaccag
    22021 cagatggtag ccattcaaga atccttgaac aaactagatg atgaaacaaa aactgttcca
    22081 gatggggcta aactcacagg agaagctgga aatgcctata atgaggtcag agattatgca
    22141 ataaaagttg tttctgaaaa caagaaactt ctatcacaga cagcagtgac aatggatgaa
    22201 ctggcaatgc aattaaccaa attgaacgat gccatgtcta aattgaaaga agctaaagcg
    22261 aaattggtac cagaggttaa accgcagccg gaaaatccag agcatcaaaa accaacaact
    22321 ccagctccgg ataccaaacc aatccctcaa ccagagggta agaaaccaag cgtaccagat
    22381 attaatcagg aaaaagaaaa agctaagctt gctgtagcaa cctacatgag caagatttta
    22441 gatgatatac aaaaacatca tctgcagaaa gaaaaacatc gtcagattgt tgctcttatt
    22501 aaggagcttg atgagtttaa aaagcaagct ctttctgaaa ttgataatgt aaataccaaa
    22561 gtagaaattg aaaatacagt ccacaagata tttgcagaca tggatgcagt tgtgactaaa
    22621 ttcaaaaaag gcttaactca ggacacacca aaagaaccag ataa
//
LOCUS       DBERMM010000031        22186 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.031, whole genome shotgun sequence.
ACCESSION   DBERMM010000031 DBERMM010000000
VERSION     DBERMM010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 22186)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22186)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22186
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.031"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(276..1499)
                     /locus_tag="ACL8AS_001464"
     CDS             complement(276..1499)
                     /locus_tag="ACL8AS_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HGS1229305.1"
                     /translation="MITKQSAFLQNRATILEFLYRNPATSRTDIVNETGLTPATTTNI
                     IKELSEQSLIYETGDEFSEFSGSGRRRKTISITDNIPYVVGGIEINVLGIFLSLCDLQ
                     GKTLFETEILNEDYPISEINSTITNMIKTAIEYVPLETKLLGFGLSIPGHYNKDSGSI
                     ITNNPIWESFNLLNVIKRFNFPFIVKNNIDCMAIGQYLFNPHNTPDNFIFLHAGLGIY
                     TSFFTKEKIGASKNPYIGEIGHTIVELNGQYCECGKKGCLQTYISDAWLIKHAQLLFK
                     NSQLTVLKSLVKTEKDIHLDTLLTAYNLGDSALRQQIDKGVNLLATSIANLLLINPAD
                     KIYINSQLLNYQPFTHEVRDKIQDQLHFVPFTRNIEIEILPYNKHRGSIGACALAIVA
                     FFIEHSNVLQDIISP"
     gene            1667..2989
                     /locus_tag="ACL8AS_001465"
     CDS             1667..2989
                     /locus_tag="ACL8AS_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HGS1229306.1"
                     /translation="MNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSL
                     FLILISWPQEAFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPS
                     AGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAE
                     IYRMFIQRGITIKMPSGVPDVVSKSFSALLPGFTTFVLWALVLKGLEAAGVAGGLNGL
                     LGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEA
                     VAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFN
                     INTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIG
                     GFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK"
     gene            2991..4877
                     /locus_tag="ACL8AS_001466"
     CDS             2991..4877
                     /locus_tag="ACL8AS_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000236922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4838 domain-containing protein"
                     /protein_id="HGS1229307.1"
                     /translation="MVIRVFDQQKNTYSSFALEELSYYMNRVFKTNIELVEEKEADIF
                     VGLVNKEDRKDHVLISLDKGKGRIESNTIVGLLIGIYRMFHEFGVVYTRPGRRHDFVP
                     ELRFEDFLDKQLSIDETASYYHRGVCIEGADSFENILDFIDWLPKIGMNSFFIQFENP
                     YSFLKRWYEHEFNPYLNKEQFSNELVQELSDRLDKELQKRGLIHHRVGHGWTGEVLGY
                     SSKFGWESGLSISEEKKPYVAEINGKRELFNTAPILTSLDFSNPDVADKMVEIIKDYA
                     KKRPDVNYLHVWLSDARNNICECENCRQELVSDQYIRILNQLDRALTSEGLDTKICFL
                     LYHELLWAPQKEKLDNPERFTMMFAPITRTFEMSYADVDFDNSIPTPKPYMRNKIILP
                     NSLEENLSYLFEWQKAFKGDSFVYDYPLGRAHYGDLGYMKISQTIYRDVSYLSNLHLN
                     GYISCQELRAGFPHNFPNYVMGEMLWKKTRSYEELIEEYFSALYGENWQSVVEYLEKL
                     SIYSSCDYFNAIGSRQSDVLANHYYIAYNLADNFLPIIEENISKLLNSQKDEWKQLSY
                     HREYVVKMAKALYLQATGKTRQAQDEWRNVLNYIRGHELLFQSNLDVYRVIEVAKNYA
                     GFHL"
     gene            5045..5389
                     /locus_tag="ACL8AS_001467"
     CDS             5045..5389
                     /locus_tag="ACL8AS_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HGS1229308.1"
                     /translation="MKSKEEINMLGFTIVAYAGDARSDLMDALAFARDGYFEQARELV
                     ESANDSIVSAHREQTNLLAEEASGDNFEVSFIMIHGQDTLMTTMLLYDQVKFFIDEYE
                     RIRKIEEHIGLQ"
     gene            5399..6811
                     /gene="lacG"
                     /locus_tag="ACL8AS_001468"
     CDS             5399..6811
                     /gene="lacG"
                     /locus_tag="ACL8AS_001468"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HGS1229309.1"
                     /translation="MENLQVKALPKEFLLGAATAAYQVEGATRVDGKGTNMWDVYLQE
                     NSPFLPDPASDFYYRYEEDITLAAEHGLQALRLSISWVRIFPDIDGEPNILAVRYYHR
                     VFQSCLKHNVIPFVSLHHFDSPQKMLETGDWLNRENIDRFIRYARFCFQEFTEVKHWF
                     TINELMSLAAGQYIGGQFPPNHHFQLSEAIQANHNMLLAHALAVLEFHQLGIEGKVGC
                     IHALKPGYPIDGQKENILAAKRYDVYNNKFLLDGTFLGYYSEDTLFHLNQILEANNSS
                     FIIEDGDLEIMKRAAPLNTMFGMNYYRSEFIREYKGENRQEFNSTGIKGQSSFKLNAL
                     GEFVKKPGIPTTDWDWNIYPQGLFDMLLRIKEEYPQHPVIYLTENGTALKEVKPEGEN
                     DIIDDSKRIRYIEQHLHKVLEARDRGVNIQGYFIWSLQDQFSWANGYNKRYGLFFVDY
                     ETQKRYIKKSALWVKGLKRN"
     gene            6880..8559
                     /locus_tag="ACL8AS_001469"
     CDS             6880..8559
                     /locus_tag="ACL8AS_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HGS1229310.1"
                     /translation="MDKLVAAIEKQQGKFEKISTNNYMMAIKDGFIATMPLIMFSSFL
                     MIIIMIPKNFGVELPSPAIVWMRKVYMLTMGVLGIIVSGTVGKSLVGNVNRKMPHGKV
                     INDISAMLAAICSYLVLTVTLVVDEKTGSTSLSTNYLGSQGLITSFVSAFITVNVYRF
                     CIKRDITIHLPKEVPGAISQAFRDIFPFSFVLLISGLLDIVSRFSLDVPFAQVFQQLL
                     TPIFKGAESYPAMMLIWFMCALLWFVGIHGPSIVLPAVTALQLSNMEENAQLLANGQF
                     PYHSLTPNFGNYIAAIGGTGATFVVPFILIFFMRSKQLKSVGKATITPVLFAVNEPLL
                     FGMPVILNPYLFVPFLMTPPVNVFLGKVFIDFFGMNGFYIQLPWTFPGPLGLLIGTNF
                     QLISFVFLSLILVVDILIYLPFCRAYDRQLLVKEDIASSNDIILEEDTSEIIPGEIDE
                     IKSKELKVLVLCAGSGTSAQLANAINEGANLTEVRVIANSGAYGAHYDIMGVYDLIIL
                     APQVRSYYREMKVDAERLGIQIVATRGMEYIHLTKNPSKALQFVLEHYQAV"
     gene            complement(8684..10123)
                     /locus_tag="ACL8AS_001470"
     CDS             complement(8684..10123)
                     /locus_tag="ACL8AS_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015079 - potassium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HGS1229311.1"
                     /translation="MNKSMIRYLLSKLLLIEAVLLLVPVAIAVYYRESSQVFTALFST
                     IGILVLLGGSGSLQKPKNQRIYAKEGVLIVALCWILWSFFGGLPFVFSGQIPSLIDAF
                     FEISSGFTTTGASILNDVSVLSRSLLFWRSFTHLIGGMGVLVFALAIMDNAKNSHLEV
                     MKAEVPGPVFGKVVSKLKNTAQILYLLYLALFSLFVIIYYLAGMPLYDSFVIAMGTAG
                     TGGFTVYNDGIAHYGSSLITYLVSIGVLVFGVNFNLYYYLMLRRIKAFFGDEELRAYL
                     VIVLVSTGLISLNTLYLYPGFSKSFEMTFFQVSNIITTTGFGYGDITNWPLFSQFILL
                     FLMAIGGSAGSTAGGLKIIRGLILSKIAKNQILSILSPHRVLTLHVNQTVIDKDTQHK
                     ILKYFVIYAMILLALIFIVSLDSNDFLVVTSAVFSCFNNIGPILGTTSSFSIFSPISK
                     ILLSFTMIAGRLEIYPILLLFMKRTWSKR"
     gene            complement(10127..11476)
                     /gene="trkA"
                     /locus_tag="ACL8AS_001471"
     CDS             complement(10127..11476)
                     /gene="trkA"
                     /locus_tag="ACL8AS_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk system potassium transporter TrkA"
                     /protein_id="HGS1229312.1"
                     /translation="MKIILVGGGKVGFALCRSLVAEKHDVLLIEQDEAVLNHIVSRFD
                     IIGILGNGADFAILEQASVQDCDIFIALTEHDEVNMIAAVLAKKMGAKETIVRVRNPE
                     YSNSYFKEKNILGFSLIVNPELLAARAIANIIDFPNALSVERFAGGRVSLMEFVVKST
                     SGLCQMPISDFRKKFGNVIVCAIEREHQIIIPSGDMTVQDKDRIFVTGNRVDMILFHN
                     YFKSRAVKSLLIVGAGRIAYYLLGILKDSRIDTKVIEINPEIASFFSEKFPNLYIVQG
                     DGTAKDILLEESAQHYDAVATLTGVDEENLITSMFLDRVGVQKNITKVNRTSLLEIIN
                     APDFSSIITPKSIAVDTIMHFIRGRVNAQYSDLQAMHHLANGQIETLQFHIKEANKMT
                     AKPLSQLKLKKGVLIAAIIRKGKTIFPTGEDMLEVGDKLLVTTLLPNITKIYDLIAR"
     gene            11665..12513
                     /locus_tag="ACL8AS_001472"
     CDS             11665..12513
                     /locus_tag="ACL8AS_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosyl-l-methionine hydroxide
                     adenosyltransferase family protein"
                     /protein_id="HGS1229313.1"
                     /translation="MNNNLLVLQSDFGLVDGAVSAMIGVALEESPTLKIHHLTHDITP
                     YNIFEGSYRLFQTVDYWPEGTTFVSVVDPGVGSKRKSVVAKTAKNQYIVTPDNGTLSF
                     IKKHVGIVAIREISEVANRRQNTEHSYTFHGRDVYAYTGAKLASGHITFEEVGPELSV
                     EQIVELPVVATIIEDHLVKGAIDILDVRFGSLWTSITREEFYKLEPEFGDRFEVTIYH
                     ADMLVYQNQVVYGKSFADVRIGQPILYINSLYRLGLAINQGSFAKAYNVGVGSSWTIE
                     IKKIEG"
     gene            12528..13076
                     /locus_tag="ACL8AS_001473"
     CDS             12528..13076
                     /locus_tag="ACL8AS_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF-type riboflavin transporter
                     substrate-binding protein"
                     /protein_id="HGS1229314.1"
                     /translation="MEIKFTIKQVVAVGIGAALFVVIGMINIPTPVPNTSIQLQYAVQ
                     ALLSIIFGPIIGLLVGLIGHAIKDSLVGYGLWWTWIIASGLFGLVVGLFRKYVRVINS
                     VFDWKDILIFNLIQLLANALVWGVLAPLGDVVIYQEAAEKVFAQGIVAGIANGVSVAI
                     AGTLLLLAYAGTQTRAGSLKKD"
     gene            13083..13295
                     /locus_tag="ACL8AS_001474"
     CDS             13083..13295
                     /locus_tag="ACL8AS_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002668516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229315.1"
                     /translation="MKIKEKTRKQVAGCSKHGFEVVDETDEVSNHTYGKAKLTWFEEI
                     FEEYKMMGKAGQLVFFDVYRLVRQVS"
     gene            13397..15079
                     /locus_tag="ACL8AS_001475"
     CDS             13397..15079
                     /locus_tag="ACL8AS_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000656554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229316.1"
                     /translation="MKEAIIEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGS
                     GKSTLGQCLNGIIPNIYKGQTYGEFLIKGQVAFDMSIYDKSHLVSTVLQDTDGQFIGL
                     SVAEDLAFALENDVTALDEMKGRVYKWAEKLDLLPLLDQRPQDLSGGQKQRVSLAGVL
                     IDESPILLFDEPLANLDPKSGQDIIELIDQIHKEEGTTTLIIEHRLEDVLHRPVDRIV
                     LINDGRILFNGSPDQLLATDLLTQNGIREPLYLTTLRQLGVDLVKEEQLADLDNLSIS
                     KGQIQLQTELVKETPALQSLFILEEVSFSYNDRPILKSLHLDIKKGEKIAIVGKNGAG
                     KSTLAKAISSFIQTEGRYLWEKQDIKGDSVAERAERVGYVLQNPNQMISTNMIFDEVA
                     LGLRLRGVNEKEIETRVYETLKICGLYEFRNWPISALSFGQKKRVTIASILVLGAEII
                     LLDEPTAGQDQKNYTEIMEFLEELHQKGHTIVMITHDMQLMLDYSDRVLVMVDGELIA
                     DTVPASLLSDPELLVKANLKETSIFNLAKKLDVDPLDLTAFYKERREGCKLN"
     gene            15064..15894
                     /locus_tag="ACL8AS_001476"
     CDS             15064..15894
                     /locus_tag="ACL8AS_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HGS1229317.1"
                     /translation="MQAKLIGYQHRDTVIHRLSGAGKLLFFILVSLAAMISYDTRMLL
                     LIAIFSVFLLYLSEIRFKDVSFVAVFATVFAVLNVLMVYLFSPEYGVGLYGERSVIWQ
                     GIGVYTLTSQELFYLLNLAIKYLCTIPLAIIFLMTTHPSQFASSLNQIGVPYKIAYSV
                     SLTLRYIPDLQEEFFTIKMSQEARGMELSKKASLMQRIKGNLLIITPLIFSSLERIDT
                     IATAMELRRFGKEKKRTWYSYQALKKGDYITLLLATLFLVVSLLLILQNQGRFYNPWK
                     "
     gene            16087..16590
                     /locus_tag="ACL8AS_001477"
     CDS             16087..16590
                     /locus_tag="ACL8AS_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (cytidine(34)-2'-O)-methyltransferase"
                     /protein_id="HGS1229318.1"
                     /translation="MTNHIVLFEPQIPQNTGNIARTCAATNSPLHIIKPMGFPIDDRK
                     MKRAGLDYWDKLEIYFYESLEDFISQMKGKLYLISKFAEKIYSEVDLSTDEDHYFLFG
                     REDKGLPEDFMREHPDKALRIPMNDEHVRSLNVSNTVCMIVYEALRQQNFAGLELVHT
                     YEVDKLK"
     regulatory      16644..16878
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            17043..17606
                     /locus_tag="ACL8AS_001478"
     CDS             17043..17606
                     /locus_tag="ACL8AS_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HGS1229319.1"
                     /translation="MTNTRRLSTIAILSAISFVLMYFDFPLLPAASFLKIEFSILPVL
                     VGLVVMDLPAALGVLLLRSLLKLLLNSQGVNTYIGLPMNIVALGVFVIVFALIWKKER
                     TTLRFLLGSLAGTIGLTLAMLVLNYVYAVPLYAKFANFDIGKILGLSNYLMTMVLPFN
                     LIEGVIFSVSFWLLYVLLKPTLKHYER"
     gene            17596..18246
                     /locus_tag="ACL8AS_001479"
     CDS             17596..18246
                     /locus_tag="ACL8AS_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HGS1229320.1"
                     /translation="MRDKQTFLMKGSFALLLFVILGYMVKFYPETLVNFDQSIQTAIR
                     GDLPDYLTILFRALTRLIDIPVIITWVVITAFVFYRKRWKIESFFMLGNLALAGLLIV
                     TFKNIYQRPRPDILHLVEEKGFSFPSGHSLAVTLMVGTLIVILSQRIKDPVWRKIVQI
                     VLGLYLVSVLVSRVYLGVHYPSDVLASLCVGLGVLFIEFPFYDKLRFQWRFKGKQK"
     gene            18274..18663
                     /locus_tag="ACL8AS_001480"
     CDS             18274..18663
                     /locus_tag="ACL8AS_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome partitioning protein ParB"
                     /protein_id="HGS1229321.1"
                     /translation="MKVNIADLHPTQLYLSEKKLQDIQMLYQSAETIQVDPISILAFG
                     DCLLITDGHHRAYQTLLADRDTISAEWDRDGGDELYHLYAQACEERKIYSVFDLEDRI
                     LAQDGYEAKWYNWCDGFNQAATLLLKR"
     gene            18668..19117
                     /locus_tag="ACL8AS_001481"
     CDS             18668..19117
                     /locus_tag="ACL8AS_001481"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1229322.1"
                     /translation="MCFVPYYKVNHCEEAFAWYQDVNLVYLVDGVKLPYSQATLEAMY
                     SYLDRHGELFWIEVKEKGEWFPIGDITLSQDNLPIVIGNSAYQHRGLGKKILSALIEL
                     ARVKGWKELRVKEIYTYNHASRRCFKSLGFVENGATEKGMSFILELV"
     gene            19245..19832
                     /gene="rpoE"
                     /locus_tag="ACL8AS_001482"
     CDS             19245..19832
                     /gene="rpoE"
                     /locus_tag="ACL8AS_001482"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="HGS1229323.1"
                     /translation="MELEVFAGQEKSELSMIEVARAILELRGRDHEMHFSDLVNEIQN
                     YLGTSNSDIREALPLFYTELNFDGSFISLGDNKWGLRSWYGVDEIDEEIIALEENDDD
                     EVAPKAKKKRVNAFMDGDSDAIDYNADDPEDEDAYEADPALSYDDENPDDEKNEVEAY
                     DAEINEIAPDDLGEDVDLNEDDDEFSDDDAETSEE"
     gene            20222..21829
                     /locus_tag="ACL8AS_001483"
     CDS             20222..21829
                     /locus_tag="ACL8AS_001483"
                     /EC_number="6.3.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003883 - CTP synthase activity [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0006241 - CTP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CTP synthase"
                     /protein_id="HGS1229324.1"
                     /translation="MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPY
                     INIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRK
                     ERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
                     QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPA
                     GQGIKNKLAQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAAAMT
                     EWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVNDAEVKINWVNAND
                     VTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEF
                     ARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAA
                     YHNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQY
                     HPELSSRPNRPEELYTAFVTAAVENSN"
BASE COUNT         6625 a         3750 c         4870 g         6941 t
ORIGIN      
        1 gagaattgta aaaacaaaaa tggggatttc atataaagtt tattctagga gtatgtatct
       61 tgaataaaaa ttgttattta agttctgggg gttatgatga atgtttttat aataataaaa
      121 tgcagctaga agaaaagtta ttttaatata aatcactcaa catagcgaga aggcggtttc
      181 ctatatggaa gtcgtcttat tttcatattg tctaaatacg agatatttac tacaggttat
      241 agttgattta aacaggtcta tagatttcta atatattaag gtgaaataat atcttgtaat
      301 acattgctat gttctatgaa aaaagcgacg atagctaatg cacaagctcc tatacttcca
      361 cgatgtttgt tgtaaggtaa aatttcaatt tctatattac gagtaaaagg aacgaagtgg
      421 agctgatctt ggattttatc cctgacttca tgagtgaaag gttgataatt aagcaattga
      481 ctgttgatat agattttatc agcaggattg atgaggagaa gatttgcaat agaagtggcc
      541 aataaattga ctcctttatc aatttgttgg cgtaaagcgg agtcgcctaa gttgtaagct
      601 gttaaaaggg tatctaaatg aatgtctttt tcagtcttta caaggctttt tagtacagtt
      661 agttgggaat ttttaaataa taattgggcg tgtttgatta accaagcatc cgaaatatat
      721 gtttgtaaac aacctttttt tccgcattca caatattgcc cattcaattc gacaatggtg
      781 tgtccaattt ctccgatata aggattttta gaggctccta ttttttcttt tgtgaaaaag
      841 gaagtgtaaa tacctaatcc agcgtgtagg aaaataaagt tatcgggggt attgtgtgga
      901 ttaaaaaggt attgtcctat agccatacaa tcgatattat tttttacaat aaaaggaaaa
      961 ttgaatcttt taattacatt taataaatta aaagattccc atatggggtt gtttgtaatg
     1021 atacttccgg agtctttgtt ataatgtcca ggtattgata agccaaatcc aagtaatttt
     1081 gtttccaaag ggacgtactc tatagctgtt tttatcatat tggtaatggt ggaattgatt
     1141 tctgaaatag gataatcttc attcaaaatt tctgtctcga aaagagtttt cccttgtaag
     1201 tcacatagac tgagaaagat acctaggacg tttatttcaa tacctccaac aacatacgga
     1261 atattatctg tgatagaaat agtttttcta cgtcttccag atccggaaaa ctcgctaaat
     1321 tcatcaccag tttcgtatat gagggactgt tcgcttagct cttttatgat gttagtcgtt
     1381 gttgctggag taagtcctgt ttcattaaca atatctgtac gggatgttgc tggatttcga
     1441 tatagaaact ccagtatagt ggctctattt tgtaaaaagg ctgattgttt tgtaatcatt
     1501 tgtttcctcc tttggtttat tttatattaa acataagaaa aaatcaatta aaattattat
     1561 tctatacaaa gaaaaaaata ttgtaaaaac aacaaaaaat atattgacaa cgctttctgt
     1621 tagtggtata tttaatttat aaaaaataaa aaaaggagtt ccggtgatga acaatatttt
     1681 agcgttttta gaaacaaaag tcgctccgtt tggtgaaaaa gttggcaacc aacggcattt
     1741 gaaagctatt cgtgaaggat ttatgatggc aatgcctttg attttagtcg gctctttatt
     1801 tcttattcta atcagttggc ctcaagaggc ttttacaaat tggctgaata gtgttggatt
     1861 gctaagtatc ttgacaacta tgaatcagtc aacagtagcg attatctcct tggtcgcttg
     1921 tttcggtatt gcctacaggt tgtcggaagg atatggtaca gatggtccgt cggcagggat
     1981 catagcctta tccagttttg tattgatggc acctcgtttt tcgagtatgg tttatgataa
     2041 aaatggggag caggtcaagc agttatttgg cggcgcaata ccattttcta gcctgaatgc
     2101 atcttctttg tttatggcga ttactattgg attggttaca gcagagattt atcgtatgtt
     2161 tatccagcgc ggaattacga taaaaatgcc aagtggtgtc ccagatgtag taagtaaatc
     2221 attttcagct cttttacctg gttttactac ttttgttttg tgggctttgg tcttaaaagg
     2281 tcttgaagcg gcaggagttg caggaggtct caacggactc ctaggtgcaa ttgttggaac
     2341 accgcttaag ttaattgcag gaacgcttcc aggtatgatt ctatgtgtta ttgtaaactc
     2401 attcttttgg ttctgtggag ttaatggggg acaagtttta aatgcttttg tagacccagt
     2461 ttggttacaa tttactacag aaaaccaaga agctgtggct gcaggacaaa cactccaaca
     2521 cattattaca ttaccgttta aagatttatt tgtatttatt ggtggcggtg gagcgactat
     2581 tggtcttgcg atttgtctct tcctatttag taagagtcgt gcgaataaaa cattaggtaa
     2641 gctagctatt ataccgtcta tttttaatat caatacagct attctattta cgtttccaac
     2701 agttttaaat ccgattatgc tgattccgtt tattgctact cctacaatca atgccttgat
     2761 tacctatgta tcaatggctg taggattagt accctataca acaggtgtaa tccttccgtg
     2821 gacaatgcca ccgattatag gaggcttcct tgcaacaggg gctagttggc gaggagctct
     2881 attacaagtt gttttgattt tggtttctgt agcaatttat tatccattct tcaaaattgc
     2941 agataaacgc aatcttgaaa aagaaaaagc tactgttgga gggaaataag atggttatca
     3001 gagtatttga tcaacagaaa aatacttatt ctagctttgc cttagaggaa ttaagttact
     3061 atatgaatcg ggtctttaag actaacatag agcttgtcga ggagaaggaa gcggatattt
     3121 ttgtaggatt agtcaataaa gaggacagaa aagaccatgt tcttatctca ttagacaagg
     3181 gtaaggggag aattgagtct aatacaattg taggtttact tattggaatt taccgaatgt
     3241 ttcatgaatt tggggttgtg tatactagac cagggcgcag acatgacttt gttccagagt
     3301 tacgatttga agatttttta gataaacagc tatctataga tgaaacagcc agttactatc
     3361 ataggggagt atgtatagag ggagcggatt catttgaaaa tatactagat ttcattgatt
     3421 ggctacctaa gattgggatg aacagttttt tcatccagtt tgaaaatcct tactcttttt
     3481 tgaaacgttg gtatgaacat gaatttaatc catatctaaa taaagaacaa ttttcaaatg
     3541 aattagtaca agaattgagt gataggttgg ataaagaatt gcaaaaaaga ggtcttattc
     3601 atcatcgtgt tggtcatgga tggacaggtg aagttttagg ttactcttca aaatttggct
     3661 gggaatcagg tcttagtatt tcagaggaga agaaacccta tgtcgctgaa ataaacggga
     3721 aacgagaatt gtttaatacg gctccgattt taaccagcct ggatttttca aatccagatg
     3781 tagctgataa gatggtagaa attatcaagg attatgccaa gaaaagacct gatgttaact
     3841 acttacatgt atggttgtcg gatgctcgta ataatatttg tgaatgcgaa aactgtagac
     3901 aagaattggt ttcggatcag tatattcgta ttctcaatca attggatagg gctttaacga
     3961 gtgagggatt agatacaaag atttgttttc tgctttatca tgagttgtta tgggcacctc
     4021 agaaagaaaa attagataat cctgaacgct ttaccatgat gtttgcaccg attacaagaa
     4081 catttgaaat gagttatgca gatgtagatt ttgacaattc catacctacg cctaaacctt
     4141 atatgcgtaa taaaattata cttccgaatt ctcttgagga aaatttatct tatctttttg
     4201 agtggcaaaa agcatttaaa ggagatagtt tcgtatatga ctatccttta gggcgtgctc
     4261 attatggcga tttaggctat atgaaaatta gtcaaactat ttacagagat gtatcttatc
     4321 tttccaacct acatttgaac gggtacattt cgtgtcaaga attacgtgcc ggattccctc
     4381 ataattttcc taattatgtc atgggggaaa tgctctggaa gaagacaaga agttatgaag
     4441 aattgattga agaatacttt tctgctttgt atggggaaaa ttggcagtct gttgttgaat
     4501 atttagaaaa attatccatt tattcctctt gtgattattt taatgcaatt ggcagccgtc
     4561 aaagtgatgt tttagcgaat cattattata tagcttacaa tctagctgat aattttttac
     4621 caattattga ggaaaatatt tctaagttat taaatagtca aaaggatgaa tggaaacagc
     4681 tcagttatca tcgtgaatat gttgttaaga tggcgaaggc tttatatctt caagcaactg
     4741 gaaaaacaag gcaagctcaa gatgaatgga gaaatgtgtt gaattatatc cgtgggcacg
     4801 aattgctatt tcaatctaat ttggatgttt atcgtgtaat tgaagtagca aaaaattacg
     4861 ctggtttcca cttataaatc ataagtatag aaaatgaact aaggtattca gagaagattg
     4921 atcctaaata ttatgaaatt taaggatttt taagatattt agggtcgact ttctatttat
     4981 atcgtagcga agtcatttta ataatgatgt gtaaaagatg gatcaagatt gaggaggaag
     5041 aaagatgaaa tcaaaagaag aaataaatat gcttggtttt acaattgtcg cttacgcagg
     5101 agatgcaagg tcagatttga tggatgcttt ggcgtttgcg agagatggat attttgaaca
     5161 ggcaagagaa ttggttgagt ctgcaaacga ctcaatagtg tctgcccatc gagaacagac
     5221 taatttatta gcggaggagg catctggaga taattttgaa gtgagtttta tcatgattca
     5281 tggtcaagat accttgatga caacgatgct attgtatgat caggtcaagt tttttattga
     5341 tgaatatgaa cgaattcgaa agattgaaga acatattggt ttgcaatgag gattagtcat
     5401 ggaaaattta caggttaaag ccttaccgaa ggagttttta ttaggagctg ctaccgctgc
     5461 ttatcaagta gagggtgcaa ctagggtaga tggcaaagga acaaatatgt gggatgttta
     5521 tttgcaagaa aacagtccgt tcttaccaga tccagctagt gatttttatt atcgttacga
     5581 agaggatata actttggcgg cagaacatgg tttgcaggct ttgcgtttat ctatttcttg
     5641 ggttcgtata tttcctgata tagatgggga gcctaatata ttagctgttc gttattacca
     5701 tagagtcttt cagtcttgct taaaacataa tgtgattccg tttgtttctt tacatcattt
     5761 tgattcgcct cagaaaatgt tagaaacagg ggattggttg aacagagaga atattgatcg
     5821 tttcatacga tatgctcgct tttgtttcca agaatttaca gaagtcaagc attggtttac
     5881 aatcaatgaa ctgatgtctc ttgctgcagg tcaatatata ggaggtcagt ttcctccaaa
     5941 tcatcatttt caattatctg aagcaattca agcgaatcat aatatgttgt tggcgcatgc
     6001 tcttgcagtc ctcgaatttc atcaattagg gattgaggga aaggtaggtt gtattcatgc
     6061 tttaaagcca ggctatccta ttgatgggca aaaagaaaat attttggcag ctaaacggta
     6121 tgatgtttat aataataaat ttctattaga tggaactttt ttgggctact acagtgagga
     6181 cacgcttttt cacttgaatc aaatattgga agctaataat tctagcttta ttattgaaga
     6241 tggtgattta gaaattatga agagagctgc acctcttaat acgatgtttg ggatgaatta
     6301 ttatcgttca gaatttattc gtgaatacaa aggtgaaaat agacaagaat ttaattcaac
     6361 aggaataaaa ggacagtctt cttttaaatt aaatgctcta ggtgaatttg taaaaaaacc
     6421 tggtattccg acaacagatt gggattggaa tatttatcct caagggttat ttgatatgtt
     6481 gcttcgtatc aaagaagaat atcctcaaca tccggtcatt tatttaactg aaaatggtac
     6541 agcccttaaa gaagttaagc cagagggcga gaatgatatt attgatgaca gtaagagaat
     6601 ccgttatatt gagcaacatt tacacaaagt tttagaggct cgagatagag gagtcaatat
     6661 tcaaggctat tttatatggt ctttgcaaga tcaattttct tgggcgaatg gctacaataa
     6721 gcgatatggt cttttctttg ttgattatga aacacagaag agatatatta agaaaagtgc
     6781 tctttgggta aaagggctaa aacggaatta aggttagcga tttgactgat gtttaatatg
     6841 ttttaaatat gaggttgaat tttttatagg aggagtttta tggataagct agtcgctgcc
     6901 attgaaaagc aacaagggaa atttgaaaaa atttctacta ataactatat gatggctatt
     6961 aaagatggat tcattgctac tatgccttta attatgtttt caagcttttt gatgattatt
     7021 attatgattc ctaaaaattt cggagtagag ttaccgagtc cagctattgt ctggatgaga
     7081 aaagtgtata tgttaaccat gggagttttg ggtattattg tttcagggac tgttggaaag
     7141 tcattagttg gaaatgttaa cagaaaaatg cctcacggaa aggtaataaa tgatatttct
     7201 gcaatgttgg cagccatatg tagttatctg gtattaactg taacgcttgt agttgatgag
     7261 aagacgggat ctacaagttt gtcgacaaac tatttaggat ctcaaggatt gataacttcg
     7321 tttgtcagtg cctttattac tgtaaatgtt taccgattct gtattaagcg agacattact
     7381 attcatttac ctaaggaagt tcctggggct atatcacaag cttttagaga tattttccct
     7441 ttttcttttg ttttacttat tagtggtttg ttagatattg tatctcggtt tagtttagat
     7501 gttccttttg cccaagtatt tcaacaacta ttgactccta tttttaaggg ggcagaatca
     7561 tatcctgcta tgatgttgat ttggtttatg tgtgctttgc tttggtttgt tggaattcat
     7621 ggaccatcta ttgtcttacc tgctgttaca gctttgcaac tgagcaatat ggaagagaat
     7681 gctcaacttc ttgcaaatgg gcagttccct tatcattctt taacacctaa tttcgggaat
     7741 tatatcgctg ctattggagg aacgggggct acctttgttg taccatttat tttgattttc
     7801 tttatgcggt ctaaacaatt aaaatcggta ggtaaagcta caattactcc tgttttattt
     7861 gcggtaaatg aacctcttct atttggtatg cctgttattt tgaatcccta tctttttgtc
     7921 ccttttttga tgactccacc agtgaatgta tttctaggaa aggtatttat tgatttcttt
     7981 ggaatgaatg gattttatat ccagttacct tggacctttc ctggtccctt gggattgtta
     8041 attggaacga attttcaact tatctccttt gtatttttat ctttgatttt agttgtcgac
     8101 atattgattt atttgccatt ctgtagagcg tatgatagac agttactggt gaaagaagat
     8161 attgcaagct caaatgatat tattttagag gaggatacaa gtgaaataat tcctggtgag
     8221 atagatgaaa taaaaagtaa ggagttgaaa gtactggttc tttgtgcagg gtctggaaca
     8281 agtgcgcaat tagccaatgc aattaacgag ggggctaact taacagaggt tagagtgatt
     8341 gcgaattcag gagcgtacgg agctcattat gatattatgg gtgtttatga tttaattatt
     8401 ctggctccac aagttcggag ttattataga gagatgaagg tggatgcaga aagattaggt
     8461 attcagatag ttgctaccag aggaatggaa tatattcatt taacaaagaa tccaagtaaa
     8521 gccttacaat ttgtattgga gcattaccaa gctgtgtagt aagtttttcc atcttttatt
     8581 tgagtaagaa ctttgcttac agacaggctt ggatttaaaa acgttccccc tttttaatat
     8641 aaaaatccct ctttcacaat tgtaaaaaga gggattttgt attttatctc ttagaccaag
     8701 ttctcttcat aaagagaagt aggattgggt aaatctccaa gcggcctgca atcattgtaa
     8761 aggagaggag aatttttgag ataggactaa agattgagaa actagaagtg gttcctagaa
     8821 taggcccgat attattgaaa cagctaaaga cagcgctggt cacgaccaga aaatcattgc
     8881 tatctaggct gacaataaag ataagcgcta gcaaaatcat agcatagatg acaaagtact
     8941 tgagaatctt atgctgggta tctttatcaa tcaccgtttg attcacatgg agggtcaaaa
     9001 cacggtgggg cgataggatt gacaaaattt ggtttttggc aatttttgaa aggatgaggc
     9061 ctcgaataat cttgagtcca cctgcagttg atccagcaga gccaccgatt gccatgagga
     9121 aaaggaggat aaactgagag aagaggggcc agttggtaat atctccatat ccaaaaccag
     9181 ttgttgtaat gatgttggaa acctggaaga aggtcatttc aaagctcttt gaaaaccctg
     9241 ggtagaggta gagggtgttg aggctaatca agcctgtaga aaccagtaca atgaccaagt
     9301 aagcccgaag ttcttcgtca ccaaagaagg ccttgatgcg acggagcatg aggtagtagt
     9361 agaggttgaa atttacccca aaaaccagaa ctccgatact gaccagatag gtaatcagtg
     9421 agctgccata gtgggcaatt ccgtcgttat agacggtaaa gcctccagtt cccgctgtcc
     9481 ccatagcaat gacaaaacta tcgtagagag gcataccagc tagataatag atgatgacaa
     9541 agagggagaa gagagctaga taaaggagat agagaatctg ggcagtgttt tttagtttgg
     9601 atacaacctt gccaaaaaca ggacctggaa cctcagcctt catcacctct aggtggctat
     9661 ttttggcatt gtccataata gcaagtgcaa aaacaagcac tcccatccct ccaatcaagt
     9721 gggtaaaact tcgccagaag aggagggaac ggctgagaac cgaaacgtcg ttcaaaatac
     9781 ttgctccagt agttgtaaac ccagaactaa tttcaaaaaa ggcatcaata aggctgggga
     9841 tttgcccaga aaagacaaag gggagaccac caaagaaaga ccaaaggatc caacagaggg
     9901 caacgatcaa gactccctcc ttggcataaa tccgttgatt ttttggcttc tgtaaactcc
     9961 ctgaaccgcc taacaatacg agaatcccta tggtcgaaaa gagggctgta aagacttggc
    10021 tcgattcacg gtaatagaca gcgatagcca caggaaccaa gaggagaaca gcttcaatca
    10081 aaagtaactt tgaaaggagg taacgaatca tacttttatt catttcttac ctcgcaatca
    10141 agtcataaat cttggtgatg tttggcaaca aggttgttac taggagcttg tctccaactt
    10201 ccaacatatc ctccccagtt gggaaaatag tcttgccctt tcgaataatg gctgcaataa
    10261 gaaccccttt tttcaatttc agttgagaaa gaggtttggc agtcatttta ttggcttcct
    10321 tgatatggaa ttgcagggtt tcgatttggc cattggctag atggtgcatg gcttgaaggt
    10381 ctgaatactg ggcattaact cgaccacgaa taaagtgcat aatcgtatct acagcgatgc
    10441 ttttaggtgt gatgatactt gaaaaatcag gcgcattgat aatctcgagg agactggtac
    10501 gattgacctt agtaatattt ttctgtacac ctaccctgtc aaggaacata gatgtaatca
    10561 gattttcctc atcgacacct gttagagtcg caacggcatc atagtgttga gcactttctt
    10621 ccagcaggat atcttttgcg gttccatctc cttgaacgat gtagagattt gggaatttct
    10681 cgctaaagaa gctggcgatt tcaggattga tttcaatgac ttttgtatcg atacgactat
    10741 ctttgagaat accaagtaga taataggcaa ttctacctgc cccaacgatg agaaggctct
    10801 tcacggcgcg tgatttaaaa taattatgga agagtatcat atcgacacgg ttaccagtga
    10861 caaagattct atctttatcc tgtacagtca tgtcaccgct tggaatgata atttgatgct
    10921 ccctctctat cgcacagaca atgacattac caaatttttt acgaaaatca gaaatgggca
    10981 tttggcaaag accgctggtg gacttgacga caaattccat gaggctaacg cgtccaccag
    11041 caaagcgttc gacagacagg gcgttgggga agtcaatgat attcgcgata gcgcgggcag
    11101 ccaagagctc aggattaacg ataagagaaa aaccgagaat attcttttcc ttgaaataag
    11161 agttagaata ttcagggttc cgcacccgaa cgatagtttc tttagctccc attttcttgg
    11221 ctagaactgc tgcaatcatg ttgacttcat cgtgctcagt cagggcgata aagatatcac
    11281 aatcttggac gctggcttgc tcaagaatgg caaaatcggc cccgttacca aggataccaa
    11341 tgatatcaaa gcgactgaca atatgattga gaacagcttc gtcttgctca atcagcaaaa
    11401 catcatgctt ttctgcaacc aaggagcgac agagggcaaa accaactttt ccccctccga
    11461 caaggataat tttcataata aaacctactt tttcatgatg taactatcat accctttttc
    11521 aagaaaaaat gcacctacta gctaataacc agagttttta gtaggaaatt tgctataagt
    11581 taaaactata ccctaaccaa ttgaaatagc tattagcgac tttctctgaa atatggtatg
    11641 ataaaggata tacaaggaga taaaatgaat aataatttac tggtattaca atcagacttt
    11701 ggtctggttg atggtgcggt atcggctatg attggagtgg ctttagaaga gtctccaacc
    11761 ttaaaaatcc atcacttgac gcacgatatc acgccttata atatttttga ggggagctat
    11821 cgtctctttc agacggtgga ttactggcct gagggaacga cgtttgtatc ggttgtcgat
    11881 ccaggtgtcg gttcgaaacg taagagtgta gttgccaaga ctgcaaaaaa tcaatacatt
    11941 gtcacgccag ataatgggac gctttccttt atcaagaaac acgttggcat tgtagccatt
    12001 cgtgagattt ctgaggtggc caataggcgt caaaacacag agcattctta taccttccac
    12061 ggtcgtgatg tctatgctta tactggtgct aaactggcca gtggtcacat tacttttgag
    12121 gaagtagggc cagagctcag tgtggaacag attgtagagc ttccagtcgt agcgaccatc
    12181 atagaagatc atctggtgaa gggagccatt gatattctgg atgtgcgttt cggttcgctt
    12241 tggacctcta tcacacggga agaattttac aagctggaac cagaatttgg tgatcgtttt
    12301 gaagtgacca tctatcatgc tgatatgctg gtctatcaaa atcaggttgt ctatggcaaa
    12361 tcatttgcag atgtgagaat tgggcaaccc atcctttaca tcaactctct ctatcgttta
    12421 ggtttggcta tcaaccaagg ttcctttgcc aaggcctata atgtaggtgt cggttcatct
    12481 tggaccattg aaataaagaa aatagaagga taaaatagga gaatagtatg gaaatcaaat
    12541 ttacaattaa acaagttgtt gctgtcggaa ttggcgctgc cctctttgtc gtcatcggga
    12601 tgatcaacat tccaacccct gttccaaata caagcatcca gcttcagtat gcggtacaag
    12661 cgctactttc tattattttt ggaccgatta tcggtttgct tgtcgggttg attggtcatg
    12721 caatcaagga ctctcttgtt ggttatggtc tatggtggac ttggattatc gctagcggac
    12781 tctttggctt agttgtggga ctttttagaa agtacgttcg cgtgatcaat agtgtttttg
    12841 actggaaaga tattcttatt tttaatctca ttcaactact tgcaaatgcc cttgtttggg
    12901 gtgtcttggc accacttgga gatgttgtga tttatcaaga agcggcagaa aaagtatttg
    12961 cacaagggat tgttgcggga attgccaatg gtgtatctgt agctattgca ggaactcttc
    13021 tcttacttgc ctatgcagga acccaaactc gtgcaggaag tttgaaaaag gactaatact
    13081 caatgaaaat caaagagaaa actaggaagc aagtcgcagg ttgctcaaaa catggttttg
    13141 aggttgtaga tgaaactgac gaagtcagta accataccta cggcaaggcg aagctgacgt
    13201 ggtttgaaga gattttcgaa gagtataaaa tgatggggaa ggctgggcaa ctagtctttt
    13261 tcgatgttta tagattagtt aggcaagtaa gctaggatag gaatcttttt ggcgctaaga
    13321 ttttaagagg agagactgca agaagggctt gatttatgat aaaatagaag tctaagaagc
    13381 gaatgaagag agtaagatga aagaagctat aattgagtgg aaggatttct ctttccggta
    13441 tgaaacacaa caagaaccga ccttgcaagg gatagacttg accatttaca agggagagaa
    13501 agtcttaatt gttggaccat ctgggtcagg taaatctacc ttgggtcagt gtttgaatgg
    13561 gattattccc aatatttaca agggtcagac atatggagaa tttttgataa agggtcaagt
    13621 agcctttgat atgagcatct atgataagtc tcatctggtt agcacagttt tacaggatac
    13681 agatgggcag tttattggct tgtctgtggc agaagatttg gcgtttgctc tggaaaatga
    13741 tgtgacagcc ctagatgaga tgaaaggtcg tgtttataaa tgggctgaaa agctggacct
    13801 tcttccttta ctggatcagc gtcctcagga tttgtcaggt ggacaaaagc agcgagtcag
    13861 tctggctggt gtcttgattg atgaaagtcc gattctcttg tttgatgagc cactcgccaa
    13921 tctagatccc aagtcaggtc aggatattat cgaattgatt gaccagattc ataaggaaga
    13981 ggggacgacg actctgatta tcgagcaccg tttggaggac gttctgcatc gccctgtgga
    14041 tcggattgtc ttgataaacg atggtcgtat cctttttaat gggagccctg accagttgct
    14101 tgcgactgat ttattgactc aaaatggaat tcgagaaccc ctttatctaa cgactctccg
    14161 tcaattaggt gtggacttag tcaaggaaga acaattagca gatctggata acttgtctat
    14221 ctcaaaaggg caaatccagt tacagacgga actggtaaaa gaaaccccag cattgcagtc
    14281 actctttata ctagaggaag tatctttttc ttataatgat agaccgattt taaaatccct
    14341 acatttagat attaaaaagg gtgaaaagat tgctattgtc ggaaaaaatg gagcagggaa
    14401 atcaactcta gccaaggcta taagtagctt tattcagacg gaaggacgct atctttggga
    14461 aaaacaggat ataaaaggcg attctgttgc agagcgggcg gaacgagtag gctatgtgct
    14521 acaaaatcct aatcaaatga tttcaaccaa tatgattttt gatgaggtgg ctctagggct
    14581 ccgtttgcga ggtgtgaatg agaaggaaat tgaaacgaga gtctatgaaa ccttgaaaat
    14641 ctgtggactt tatgaattcc gtaattggcc tatttctgcc ctgtcatttg gtcagaaaaa
    14701 acgtgtcacc attgcttcaa ttttggtctt aggagctgaa attattctcc tagatgaacc
    14761 gactgcaggt caagatcaga agaactatac tgagattatg gaatttctcg aagagttaca
    14821 tcaaaaaggg cataccattg tcatgattac ccatgatatg caattgatgc tggattattc
    14881 agaccgggtc cttgtcatgg tggatggaga attgattgcc gatactgttc cagccagtct
    14941 gttgagcgat cctgagctgt tagtaaaagc caatctaaaa gaaacctcca tctttaactt
    15001 ggctaagaaa ctagatgtgg atccactgga tttaacggca ttttacaaag aaaggagaga
    15061 gggatgcaag ctaaattaat cggttaccag catagagata ctgtgattca tcgcttgtca
    15121 ggagctggga aacttctctt tttcattctg gtatcattgg cggccatgat tagctatgat
    15181 accagaatgc tcttgctgat tgccatcttt tcagtctttc tcctctattt atcagaaatc
    15241 cgctttaaag atgtctcctt tgtagccgtt tttgcgacgg tatttgccgt tttaaacgtt
    15301 ttgatggtct atctcttttc tcccgagtat ggggttggac tttatggaga gagaagtgtg
    15361 atttggcagg gaatcggtgt ctacactcta accagccagg agctctttta tctgctaaat
    15421 ttggccatta agtatctttg caccattcct ctggctatta tctttttgat gacaacccat
    15481 cctagtcagt ttgcttccag tttaaatcaa attggtgtgc cctataagat tgcttattct
    15541 gtcagcctga ccttgcgcta tattccagat ttgcaggaag aattctttac tatcaagatg
    15601 tctcaggagg cgcgtgggat ggaattatcc aagaaagctt ctcttatgca acgaatcaaa
    15661 ggcaatctgc tcattattac gcccttgatt tttagctcgc tagaacgcat tgataccatt
    15721 gcgactgcca tggagcttcg ccgctttggg aaagagaaaa aacgcacatg gtatagttat
    15781 caggccttga aaaaaggaga ctatattacc ttgctcttgg caaccttgtt tttagtagtt
    15841 agtttactac ttatcttgca gaatcaggga cgattttaca acccttggaa atagcttgaa
    15901 aaaattgaaa aaatcaagtc atttctattg acaatgattc tgaaagtgtt atactaagaa
    15961 agtagtttcg ctgatttact tcaaacctgt tgtgaggtaa gttaacgatg ccttaaccac
    16021 gctgtttgct gagcttgact ccgggcagtg tggctatttt tttgcaatgg tgaaaggaag
    16081 caagtcatga caaatcacat tgtattattt gaacctcaaa ttccacaaaa tacaggcaat
    16141 atcgcgcgta cttgcgctgc gaccaattct cccctccaca tcatcaagcc tatgggcttt
    16201 cctattgatg accgcaagat gaagcgggct ggattggatt actgggataa gctagagatt
    16261 tatttttacg agagtttaga agatttcata tctcagatga agggaaaact ctatctgatt
    16321 tcgaaattcg cggaaaaaat ctattctgag gtggatttat cgactgacga ggaccattat
    16381 tttctctttg gacgtgaaga caagggctta cctgaagatt ttatgcgaga acatcctgat
    16441 aaggctctcc gtattcccat gaatgatgaa catgtccgca gtctcaatgt gtctaatacc
    16501 gtctgcatga ttgtctatga ggctcttcgc cagcagaact ttgcaggtct tgagctcgtc
    16561 catacctatg aagtggataa attgaaataa aaaatgaaaa tgaacaaaat gcttgcgctt
    16621 gcaagcgttt tttgttatga taaaagagtc ttcagggcag ggtgtgattc ccgaccggcg
    16681 gtgactttaa ctaggaaatg atcttttcct tttatacttt gttgacaagc tttgcctaac
    16741 cagaagttat gcctacagct tgtcgcctag tctaaaagaa aaatctctat ttctttctct
    16801 ttaaagaagt ccgcgagcgc aagctgatgt ggtgagattc cacaaccgac agtatagtct
    16861 ggatgggaga agacgaaaga atagctttgt ctgttttgat agatttatag ccggattgta
    16921 accacttgct ttgtttttct ttaatagagt aagagggaac ttttgggata taaaaagtga
    16981 gaatagatag aggaatcctt tccaacttct tctgatttta tagaaaattg gaggaacctg
    17041 ttatgacaaa cacacgtcga ctttcgacca ttgcaattct atcagccatc tcatttgtgc
    17101 tgatgtactt tgattttccg cttttaccag cggcatcttt cctcaagatc gaatttagta
    17161 tcttgccagt ccttgtgggt ctggtggtca tggatttgcc tgctgctcta ggagtgctct
    17221 tgcttcgctc actcttgaag ttgcttctta acagccaagg agtgaatact tacattggtt
    17281 tgccgatgaa tatcgtagct ttgggagttt ttgtcatcgt atttgctttg atttggaaaa
    17341 aggaacggac aacccttcgt ttcctactag gctctctagc tggaactatt ggtttaacct
    17401 tggccatgtt ggttctcaac tatgtttatg ctgttccttt gtacgctaag tttgctaact
    17461 ttgatattgg aaaaattttg ggactttcca actacctaat gaccatggta ttacctttta
    17521 acttgattga aggtgttatc ttttccgttt cattctggtt gttgtatgtt ctcttgaaac
    17581 caaccttaaa acattatgag agataaacaa acatttttaa tgaagggcag ttttgccctt
    17641 ttacttttcg ttattcttgg ctacatggtc aaattttacc ctgaaacgct ggtcaatttt
    17701 gaccaatcga ttcagactgc cattcgagga gacttaccag attatttgac tattcttttt
    17761 cgagccctca cacgtctgat tgatatccca gtgattatca cttgggttgt cattacagct
    17821 tttgtctttt atcgtaagcg atggaagata gaaagtttct tcatgctggg aaatctggct
    17881 ttggcaggtc ttttaatcgt gacctttaaa aatatctacc agcgcccacg gccagatatc
    17941 ttacatctgg tggaggagaa gggattttcc ttcccaagtg ggcattctct ggctgtaacc
    18001 ttgatggtag gtactttgat tgttattctt agtcagcgga ttaaagatcc agtctggaga
    18061 aaaatcgtac aaatcgtcct tggcctctac ctagtcagtg tgctggtatc aagagtctat
    18121 ctgggagttc attacccatc agacgtcctt gccagtctct gtgtgggctt gggagtcctg
    18181 tttatcgagt ttcccttcta tgacaagctc cgcttccaat ggcgatttaa aggcaaacag
    18241 aagtgagtat cgaattccct tgaggagaaa gaaatgaaag tcaacatagc agatcttcat
    18301 ccgactcaac tatatttatc agaaaagaag ttgcaagata ttcagatgct ttaccagtcg
    18361 gcagaaacaa tccaagtcga tccaatcagt attcttgcct ttggagattg tttgctgatt
    18421 acagatgggc atcacagggc ttatcagact ttattggcag atcgggatac gatttctgct
    18481 gagtgggata gagatggtgg tgatgaacta tatcatctct atgcgcaagc ttgcgaggaa
    18541 agaaagattt actctgtttt tgatttagaa gatcgtatcc tagctcaaga tgggtatgaa
    18601 gcaaaatggt ataactggtg tgatggtttt aatcaagcag caactctttt gttgaaaagg
    18661 tagtgcattg tgttttgttc cttattataa ggtcaatcat tgtgaggaag cttttgcttg
    18721 gtatcaggat gtgaacttgg tttacctcgt agatggggtg aagcttcctt acagtcaagc
    18781 gaccttggaa gccatgtatt cctatttgga tcggcatggt gagctttttt ggattgaagt
    18841 caaggagaag ggagaatggt ttccaattgg ggatattaca ctatctcagg ataatctccc
    18901 cattgtgatt gggaattccg cttaccaaca tcgaggactt ggaaaaaaga ttctaagtgc
    18961 tttgattgaa ttggctcgag taaaaggatg gaaagaattg agagtcaagg aaatctacac
    19021 ctacaatcat gcttctagga ggtgtttcaa gtcgcttgga tttgtggaaa atggagcaac
    19081 agaaaaagga atgagtttta tattggaatt agtctaatcc tgccattttc tcccccttaa
    19141 cctttgacta ttctgcaaaa ttatcgtaaa ataaagagta aatgataaaa tgaggtcaga
    19201 gtctgttcgc tctggcgata gtagtataaa tgaggagaaa cgctttggaa ttagaagtat
    19261 ttgctgggca agaaaaaagt gaactatcta tgattgaggt agcgcgtgct atcttggaac
    19321 ttcgtggtcg cgatcatgag atgcatttta gcgatcttgt aaacgaaatt caaaactacc
    19381 ttggaacatc aaacagcgat atccgcgaag ctttgccttt gttctacaca gagttgaact
    19441 ttgacggtag cttcatctca cttggggaca acaaatgggg tcttcgttca tggtatggtg
    19501 tggacgaaat cgacgaagaa atcatcgctc ttgaagaaaa tgacgacgat gaagtagcac
    19561 caaaagctaa gaaaaaacgt gttaatgcct ttatggatgg tgattcagat gccattgact
    19621 acaatgcaga tgatccagaa gacgaagatg catacgaagc agatccagct ctttcatacg
    19681 atgatgaaaa tccagatgat gaaaaaaatg aagtggaagc ttatgatgca gaaatcaacg
    19741 aaatcgctcc agatgacttg ggagaagatg tggatctcaa cgaagacgac gacgagtttt
    19801 cagatgacga cgctgaaacc agcgaggaat aagagttagc tattgacaat tatcctattt
    19861 ttaggtatca tattgtttgg gcacctcttt tagaggtcgg ggctccctag ttcttaggga
    19921 gctatttttg ttttttcaag aagttatctt cttgtatttt atactcaatg aaaatcaaag
    19981 agcaagctag gaaactagcc gtaggctgct caaaacactg ttttgaggtt gtagataaga
    20041 ctgacaaagt caggaacaca tatctacggc aaggcgacgt tgacgcggtt tgaagagatt
    20101 ttcgaagagt attagttgtg aatctggtgc agtcgtccca gattattctt attagtaggg
    20161 tcttgttttc tatatcccct cgtagttaac aagaccttga gcattttaga aagaggaatc
    20221 tatgtctacg aaatatattt ttgtaactgg tggtgtggta tcgtccattg ggaaagggat
    20281 tgtggcagcg agtctaggcc gtctcttgaa aaatcgtggt ctcaaagtaa ccattcaaaa
    20341 gtttgaccct tatatcaata ttgatccggg aaccatgagt ccttaccagc acggggaagt
    20401 ttttgtgaca gatgacggag ctgagacaga tttggacttg ggtcactatg aacgtttcat
    20461 cgatattaat ctcaacaaat attccaacgt gacaactggg aaaatttaca gtgaagttct
    20521 tcgtaaagaa cgccgtggag aataccttgg ggcaactgtt caagtcattc ctcatatcac
    20581 agatgctttg aaagaaaaaa tcaagcgtgc cgctctaacg accgactctg atgtcattat
    20641 cacagaggtt ggtggaacag taggagatat cgagtccttg ccattcctag aggctcttcg
    20701 tcagatgaag gcagatgtgg gtgcggataa tgtcatgtat atccatacaa ccttgcttcc
    20761 ttacctcaag gctgctggtg aaatgaaaac caaaccaacc caacactctg tcaaagaatt
    20821 gcgtggcttg ggaatccaac caaatatgtt ggttattcgt acagaagagc cagctggtca
    20881 aggaattaaa aataaactgg cccagttctg tgatgtggca ccagaagccg ttatcgaatc
    20941 gttggatgtt gaacaccttt accaaattcc actgaacttg caggcacaag ggatggacca
    21001 aattgtttgt gatcatttga aattagacgc accagcagcg gctatgacag aatggtcagc
    21061 catggtggat aaggtcatga acctcaagaa acaagttaag atttcccttg ttggtaagta
    21121 tgtggagttg caagatgcct atatctcagt ggtcgaagcc ttgaaacact ctggctatgt
    21181 caatgatgca gaagttaaaa tcaattgggt caatgccaat gatgtgacag cagagaatgt
    21241 agcagaactc ttgtctgatg cagacgggat catcgtacca ggtggttttg gtcaacgtgg
    21301 tacagaaggg aaaatccaag ccatccgcta tgcgcgtgaa aatgatgttc caatgttggg
    21361 agtctgcttg ggaatgcagt tgacatgtat cgagtttgct cgtcacgttt taggtcttga
    21421 aggtgccaat tctgcagagc ttgcaccaga aacaaaatac cctatcattg atatcatgcg
    21481 tgatcagatt gatattgagg atatgggtgg aacccttcgt ttgggacttt atccgtctaa
    21541 gttgaaacgt ggctctaagg ctgctgctgc ttatcacaat caagaagtgg tgcaacgccg
    21601 tcaccgtcac cgttatgagt ttaataatgc cttccgtgag cagtttgagg cagcaggttt
    21661 tgtcttttca ggagtttctc cagacaatcg tttggtagaa atcgtggaaa ttcctgaaaa
    21721 taaattcttt gtagcttgtc agtatcaccc tgaactgtca agccgtccaa accgaccaga
    21781 agaactctac actgcctttg ttactgcagc ggttgagaac agcaattagc aaaatcagaa
    21841 cctttgagaa aaatctcaga ggttttttgc atacgatgat attgcagtat atctgaggta
    21901 ggggtcctct gtatgtacct gctaccgttg aaatcaatag ggactccctc ttgccctgtg
    21961 ctagtgaatg gatttatcag tatattgaaa tgaaataaaa tttgaacaaa ttaattcgga
    22021 aagccaaatc aatttctagc aaagttttag gaactggatt gtatagtgaa ttgaaataag
    22081 atgtgaacat ctctatcagg aaagtcaaat taatttatat aaatatttta gcagtcaaga
    22141 tggactgtta tagattcaat acactatact tttttaattt aatcca
//
LOCUS       DBERMM010000032        21830 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.032, whole genome shotgun sequence.
ACCESSION   DBERMM010000032 DBERMM010000000
VERSION     DBERMM010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 21830)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21830)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21830
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.032"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(36..884)
                     /locus_tag="ACL8AS_001484"
     CDS             complement(36..884)
                     /locus_tag="ACL8AS_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative RNA methyltransferase"
                     /protein_id="HGS1229325.1"
                     /translation="MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDL
                     AKFGYVNLAPQIKQSANYNKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDI
                     GCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDAN
                     MDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIK
                     EHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEI
                     LVGKAF"
     gene            1036..1314
                     /locus_tag="ACL8AS_001485"
     CDS             1036..1314
                     /locus_tag="ACL8AS_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003075836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6110 family protein"
                     /protein_id="HGS1229326.1"
                     /translation="MLKEVLTVAKVAKKSSLFLGGVAFGTLGLKILASKEAKKGYSKA
                     LAKAYKLKDELDASVSVVKQHGDDVLQDAKYLYEQEKKEEQLDSLIGE"
     gene            1316..3379
                     /locus_tag="ACL8AS_001486"
     CDS             1316..3379
                     /locus_tag="ACL8AS_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HGS1229327.1"
                     /translation="MSFKVLHRGYQHIRLSSSFSLTLDIQDYLRSLARDEKGIESIQF
                     YMDQQHFTLRIKEGFSVLDNAEAFLKRIDKGKVSELMTLPIRREESAYSIVSGAAVKR
                     VLFRSFVPYPIRYIWTCYQALGYIREAYQTLARKELTMEVLDCSAILLSLFMNQSKTA
                     SNIMFMLDLGNHLDQWSLKKTATDLEQSLLAKESDVFLVQGDTVVSIKSSDVQIGDVL
                     ILSQGNEILFDGQVVSGLGMVNESSLTGESFPVEKRESDLVCANTVLETGELRIRVTD
                     NQMNSRILQLIELMKKSEENKKTKQRYFIKMADKVVKYNFLGAGLTYLLTGSFSKAIS
                     FLLVDFSCALKISTPVAYLTVIKEGLNREMVIKDGDVLEKYLEVDTFLFDKTGTITTS
                     YPIVEKVLPFGDYSEEDILRISACLEEHIYHPIANAIVKQAEIEGIEHEEMHGKLQYI
                     ASKGIKSHIDGQPVLIGNYVLMQDEQIHISSEQNALIEEYKSHYNLLFLAYQNELIGM
                     FCIHTPLRKEAKTALDKLKAQGKKLILATGDTLIRTEELVKDLPFDQVYTDLKPDGKF
                     ELVEKLQKAGHTILMVGDGLNDSAALTLSDIGVVMNESADISKQMSDILLLDNRLDFF
                     QELDSLSSSLQTLIKKNIQDTVVVNSSLIGFGLFNWFSPSNLSILHNLTTLRIVLRSL
                     SIKNR"
     gene            complement(3457..4713)
                     /gene="tyrS"
                     /locus_tag="ACL8AS_001487"
     CDS             complement(3457..4713)
                     /gene="tyrS"
                     /locus_tag="ACL8AS_001487"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004831 - tyrosine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HGS1229328.1"
                     /translation="MHIFDELKERGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSL
                     HLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQ
                     GQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIET
                     GISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVIT
                     VPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAVRFLKIFTFLSLDE
                     IEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKEL
                     KQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQDLDYV
                     LSDADKLENELTVIRRGKKKYFVLTY"
     gene            4855..7320
                     /gene="pbp1b"
                     /locus_tag="ACL8AS_001488"
     CDS             4855..7320
                     /gene="pbp1b"
                     /locus_tag="ACL8AS_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP1B"
                     /protein_id="HGS1229329.1"
                     /translation="MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKS
                     AIFPAILLSIKALFNLLFVLGFLGGMLGVGIALGYGVALFDKVRVPQTEELVNQVKDI
                     SSISEITYSDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV
                     IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEI
                     LTTYLNVAPFGRNNKGQNIAGARQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPY
                     ENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGI
                     SRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITT
                     TIDQKIHSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNH
                     AFDTKRSPASTTKPLLAYGIAIDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMT
                     LGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQ
                     HTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVL
                     SSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNH
                     SLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDPSVVKSEVLKSTGQKPGKVS
                     VEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSS
                     SSSSSSDSSNSSTTRPSSSRARR"
     gene            7385..8296
                     /locus_tag="ACL8AS_001489"
     CDS             7385..8296
                     /locus_tag="ACL8AS_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HGS1229330.1"
                     /translation="MNQYQKKIVNGKIYSLLSGLIWGICGILGEYFFTHYQVSSGWIT
                     SMRLTLAGSLVLIWSAIQLKSQVLDIWRDKKNYLPFLAYAILGIFSVQYFFYLCVEYS
                     NATTATILQFISPVFILFYNRLVYQKRASKSAVFYVLVAMLGVCLMATKGDLSQLSMT
                     PLALITGLLSAMGVMFNVILPQPFAKRYGFVPTVGWGMILAGLFSNVLSPVYQLSFTL
                     DIWSILICLIIAFFGTAFAFFISMKAVSLVSPLVVAVISASEPLSSALLSVLFLGLVV
                     DWSLLLAIALIILPMIFLSIEEAKESR"
     gene            8526..9224
                     /gene="dapD"
                     /locus_tag="ACL8AS_001490"
     CDS             8526..9224
                     /gene="dapD"
                     /locus_tag="ACL8AS_001490"
                     /EC_number="2.3.1.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047200 - tetrahydrodipicolinate
                     N-acetyltransferase activity [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HGS1229331.1"
                     /translation="MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLG
                     NVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEI
                     GDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAE
                     PVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQ
                     TQQKTALEDALRTL"
     gene            9292..10422
                     /locus_tag="ACL8AS_001491"
     CDS             9292..10422
                     /locus_tag="ACL8AS_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HGS1229332.1"
                     /translation="MLDLIQTRRDLHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQI
                     RTWRTGILVYLQGSQPERTIGWRTDIDGLPIVEQTGLLFASQHQGRMHACGHDFHMTI
                     ALGCLERALEEQPKNNLLFLFQPAEENEAGGMLMYEDGAFGDWLPDQFYGLHVRPDLK
                     VGQIATNTHTLFAGTCEVKIRFKGKGGHAAFPHEANDALVVASYFVTQVQSVVSRNVN
                     PIEGAVVTFGVFQAGTTNNVITDTAFLHGTIRALTQDMSLLVQKRVKTVAEGVAAAFD
                     MEVEVELKQGGYLPVENNPALARELMDFFDEKDGIELIDIEPAMTGEDFGYLLSKVDG
                     VMFWLGIDSPYALHHPQMSPKEEVLAIGVAAVSSFLKKKAAE"
     gene            10434..10973
                     /locus_tag="ACL8AS_001492"
     CDS             10434..10973
                     /locus_tag="ACL8AS_001492"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030272 - 5-formyltetrahydrofolate
                     cyclo-ligase activity [Evidence IEA];
                     GO_process: GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HGS1229333.1"
                     /translation="MKSELRKQVLHEMKALSQEQKQAIDQALTERILQHPFYQEAKVI
                     ATYLSFSHEFQTRELIEQALKDGKKVLIPKTYPKGRMEFVVYDPQQLVKTSFALLEPQ
                     GDLEVVDVSQIDLIHVPGLAFTTDGYRIGYGGGYYDRYLEHFSGRTLSTVYPCQIQDF
                     IPENHDIPVQEVLIDEGNL"
     gene            10957..11634
                     /locus_tag="ACL8AS_001493"
     CDS             10957..11634
                     /locus_tag="ACL8AS_001493"
                     /EC_number="3.4.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HGS1229334.1"
                     /translation="MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFG
                     AMYGPAIRLFPEQIWRLLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYL
                     LSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIILRYATRNPYIQQLGQSYLTLFVV
                     NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILL
                     FYKGMGM"
     gene            complement(11701..12600)
                     /gene="galU"
                     /locus_tag="ACL8AS_001494"
     CDS             complement(11701..12600)
                     /gene="galU"
                     /locus_tag="ACL8AS_001494"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003983 - UTP:glucose-1-phosphate
                     uridylyltransferase activity [Evidence IEA];
                     GO_process: GO:0006011 - UDP-glucose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HGS1229335.1"
                     /translation="MTSKVRKAVIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVE
                     EALKSGIEDILVVTGKSKRSIEDHFDSNFELEYNLKEKGKTDLLKLVDETTGMRLHFI
                     RQTHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITDEKAVPLTKQLMDDYERTHAST
                     IAVMPVPHDEVSAYGVIAPQGEGKDGLYSVETFVEKPAPEDAPSDLAIIGRYLLTPEI
                     FEILEKQAPGAGNEIQLTDAIDTLNKTQRVFAREFKGARYDVGDKFGFMKTSIDYALK
                     HPQVKDDLKNYLIQLGKELTEKE"
     gene            complement(12622..13638)
                     /locus_tag="ACL8AS_001495"
     CDS             complement(12622..13638)
                     /locus_tag="ACL8AS_001495"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000415108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009331 - glycerol-3-phosphate
                     dehydrogenase (FAD) complex [Evidence IEA];
                     GO_function: GO:0047952 - glycerol-3-phosphate
                     dehydrogenase [NAD(P)+] activity [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0046168 - glycerol-3-phosphate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HGS1229336.1"
                     /translation="MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINT
                     HHTNKHYFKDVVLDENIIAYTDLAETLKDVDAILFVVPTKVTRLVAQQVAQTLDHKVI
                     IMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKD
                     LQTAQYVQELFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAII
                     ARGLAEITRLGVALGANPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIE
                     ANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAE
                     NEWS"
     gene            13808..13966
                     /locus_tag="ACL8AS_001496"
                     /pseudo
     CDS             13808..13966
                     /locus_tag="ACL8AS_001496"
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            14155..14289
                     /locus_tag="ACL8AS_001497"
     CDS             14155..14289
                     /locus_tag="ACL8AS_001497"
                     /inference="COORDINATES: protein motif:HMM:NF037495.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229337.1"
                     /translation="MFEEYYDRLPEEERFIIPNYSYLALTNYTVQKLPEKLVEILSFW
                     "
     gene            complement(14404..14835)
                     /locus_tag="ACL8AS_001498"
                     /pseudo
     CDS             complement(14404..14835)
                     /locus_tag="ACL8AS_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(14897..15547)
                     /gene="phoU"
                     /locus_tag="ACL8AS_001499"
     CDS             complement(14897..15547)
                     /gene="phoU"
                     /locus_tag="ACL8AS_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA];
                     GO_process: GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA];
                     GO_process: GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HGS1229338.1"
                     /translation="MRNQFDLELHELEQSFLGLGQLVLETASKTLLALASKDKEMAEL
                     IINKDHAINQGQSAIELTCARLLALQQPQVSDLRFVISIMSSCSDLERMGDHMAGIAK
                     AVLQLKENQLAPDEEQLHQMGKLSLSMLSDLLVAFPLHQASKAISIAQKDEQIDQYYY
                     ALSKEIIGLMKDQETSIPNGTQYLYIIGHLERFADYIANICERLVYLETGELVDLN"
     gene            complement(15562..16314)
                     /gene="pstB"
                     /locus_tag="ACL8AS_001500"
     CDS             complement(15562..16314)
                     /gene="pstB"
                     /locus_tag="ACL8AS_001500"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="HGS1229339.1"
                     /translation="MGTFSVRHLDLFYGDFQALKNISIQLPERQITALIGPSGCGKST
                     FLKTLNRMNDLVPSCHIEGQVLLDEQDIYSSKFNLNQLRKRVGMVFQQPNPFAMSIYD
                     NVAYGPRTHGIRDKKQLDALVEKSLKGAAIWDEVKDDLKKSAMSLSGGQQQRLCIARA
                     LAVEPDVLLMDEPTSALDPISTLKIEDLIQQLKKDYTIIIVTHNMQQASRISDKTAFF
                     LTGEICEFGDTVDVFTNPKDQRTEDYISGRFG"
     gene            complement(16316..17131)
                     /gene="pstA"
                     /locus_tag="ACL8AS_001501"
     CDS             complement(16316..17131)
                     /gene="pstA"
                     /locus_tag="ACL8AS_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HGS1229340.1"
                     /translation="MSKYLLKLLVYCFSALTFGSLFLIIGFILIKGLPHLSLSLFSWT
                     YTSENISLMPAIISTVILVFGALLLALPIGIFAGFYLVEYTKKDSLCVKIMRLASDTL
                     SGIPSIVFGLFGMLFFVVFLGFQYSLLSGILTSVIMVLPVIIRSTEEALLSVSDSMRQ
                     ASYGLGAGKLRTVFRIVLPVAMPGILAGVILAIGRIVGETAALMYTLGTSTNTPSSLM
                     SSGRSLALHMYMLSSEGLHVNEAYATGVILIITVLMINTLSSSLSRKLVKGAS"
     gene            complement(17124..17987)
                     /gene="pstC"
                     /locus_tag="ACL8AS_001502"
     CDS             complement(17124..17987)
                     /gene="pstC"
                     /locus_tag="ACL8AS_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HGS1229341.1"
                     /translation="MIKQAFKEAVFRAIFFMSATVAVVAILLICFFIFSNGLPFMANY
                     GFARFLLGSDWSPTNIPASYGILPMIVGSLLITLGAIVIGVPTGILTSVFMVYYCPKP
                     VYGFLKSAINLMAAIPSIVYGFFGLQLLVPWIRSFLGNGMSVLTASLLLGIMILPTII
                     SLSESAIRTVPKTYYSGSLALGASHERSIFSVILPAARSGILSAVILGIGRAVGETMA
                     VILVAGNQPIIPSGLFSGTRTLTTNIVLEMAYASGQHREALIATSAVLFFLILLINAY
                     FAYLKGKSSYE"
     gene            complement(18105..18980)
                     /locus_tag="ACL8AS_001503"
     CDS             complement(18105..18980)
                     /locus_tag="ACL8AS_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HGS1229342.1"
                     /translation="MKFKKMLTLAAIGLSGFGLVACGNQSAASKQSASGTIEVISREN
                     GSGTRGAFTEITGILKKDGDKKIDNTAKTAVIQNSTEGVLSAVQGNANAIGYISLGSL
                     TKSVKALEIDGVKASRDTVLDGEYPLQRPFNIVWSSNLSKLGQDFISFIHSKQGQQVV
                     TDNKFIEAKTETTEYTSQHLSGKLSVVGSTSVSSLMEKLAEAYKKENPEVTIDITSNG
                     SSAGITAVKEKTADIGMVSRELTPEEGKSLTHDAIALDGIAVVVNNDNKASQVSMAEL
                     ADVFSGKLTTWDKIK"
     gene            complement(19147..20478)
                     /gene="pnpS"
                     /locus_tag="ACL8AS_001504"
     CDS             complement(19147..20478)
                     /gene="pnpS"
                     /locus_tag="ACL8AS_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system histidine kinase PnpS"
                     /protein_id="HGS1229343.1"
                     /translation="MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGLGG
                     YWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLKSLAQYVSGLKTKVSQQDQQYKD
                     LAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
                     HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLN
                     LAFVSNASHELRTPVTSIKGFAETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLL
                     TLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQ
                     ILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNK
                     GRSRQTGGTGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD"
     gene            complement(20479..21186)
                     /locus_tag="ACL8AS_001505"
     CDS             complement(20479..21186)
                     /locus_tag="ACL8AS_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HGS1229344.1"
                     /translation="MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAET
                     EPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLT
                     KPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
                     LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKA
                     PQFIRTIRGYGYKFKEL"
     gene            complement(21270..21755)
                     /locus_tag="ACL8AS_001506"
     CDS             complement(21270..21755)
                     /locus_tag="ACL8AS_001506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HGS1229345.1"
                     /translation="MAPTDKEDLIRTLELAPHVEGGYFRQTKKASDTINLAGKGRALY
                     TSIYFLLEETNPSHFHRLTADEIWYFHAGSPLTVHMITADGHYEAVTLGLDISKGQQL
                     HYCVPKGTIWGSTVDKDDALVSCLVAPGFEFEDFELFERVDLLATYPEHKEMIERLTR
                     Y"
     gene            21741..21830
                     /locus_tag="ACL8AS_001507"
                     /pseudo
     CDS             21741..21830
                     /locus_tag="ACL8AS_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
BASE COUNT         6309 a         4186 c         4756 g         6579 t
ORIGIN      
        1 tacggcaagg cgacgttgac gtggtttgaa gagtattaga atgctttccc aaccagaatc
       61 tctgcttcga tggtaatctc tgtcagttgg ctccagtcaa tcttgctctg gtcaacgtga
      121 aagaggagag gagtcatact gagtagggct tggagttgtt ctgctgtgat agtcttagtc
      181 agagaggcag tttgactaga taggatggta aagtgttcct ggaaatgctc cttgatatct
      241 tggttagaat actccttgtt tgtcagctgg tcctgtactc tttgacggat ttctttgagg
      301 tgattttcag ttgggataac ctttatcaag ataccgtctt tggataaaac gcgacgaaat
      361 tctccatagt tggcaggtga gaagatatca agcagaatat ccatgttagc gtcttttata
      421 ggaaggcgtg ccaagtcgcc aacgaaccaa ttgactgccc agttgggttc acttttagca
      481 gcgatttgga ctgaatcttt ggagatgtca aaggcataga aagttttttc agagtgactt
      541 tcttgtagtt tgcgagaata gaatccttca ccacaaccga tatccaaaat tgttgtggta
      601 gtttttgagc ttgcaagcaa gtcagataca gcatctaaga tagcttggta aaagccggct
      661 tctaggattt gttgacggtt ttgaaaattt tccttgttat agttagcaga ttgcttgatt
      721 tgaggtgcta gattgacata gccaaatttc gccaagtcaa aagaatgacg gttgcagcac
      781 ttgaaattag tctctaacag agtcagattt tcttgacaga taggacaggc aaaggcagtc
      841 gcagaagcaa aacgctgaag tttgggcttg agatttgtat tcatagttta agtgtatcaa
      901 aagaggcaaa tgaaagcaac tttaggaata agtagatggg agattcagta gaaataaaac
      961 taattctcca atttatagaa tgaaattgct tttatatcta aattgctata taataatgat
     1021 aaggaggaaa taagtatgtt aaaagaagta ttaaccgttg caaaagttgc gaaaaaatct
     1081 tcattatttt tgggtggtgt cgcatttggt acccttggtt tgaaaatctt agcaagtaag
     1141 gaagctaaaa aaggttattc taaagctttg gctaaggctt acaagttgaa agacgagcta
     1201 gatgcatctg tttctgttgt gaagcaacat ggagacgatg tcttgcaaga tgccaaatat
     1261 ttgtacgagc aagagaaaaa agaagagcaa ttagatagcc ttataggtga ataatatgtc
     1321 ttttaaagtg ctacatagag gataccaaca tatccgacta tcatcttctt tttcacttac
     1381 cttggatatt caagactatc ttcgttcctt ggcgagagat gaaaagggga ttgagtctat
     1441 ccagttttac atggatcaac agcactttac tctacgcata aaagaaggct tttctgtatt
     1501 agataatgca gaagcctttt taaaaagaat tgataaaggg aaagtttctg agttgatgac
     1561 tcttcccatt cgtagagaag agagtgctta ttctattgtt tcaggtgcag cggttaagcg
     1621 tgtacttttt cgtagttttg tgccgtatcc tattcgctat atatggactt gttatcaggc
     1681 tttgggttat attagagaag cctatcaaac actagcgcgt aaggaactaa cgatggaagt
     1741 cttggactgt tcggctattt tattgtcttt gtttatgaac caatccaaga cagctagcaa
     1801 tatcatgttt atgcttgatt tggggaatca tttagatcag tggtccttga aaaaaactgc
     1861 aacagattta gaacagagtc ttcttgcaaa agagagcgat gtattcctag tacagggcga
     1921 tacggttgtt agtatcaaga gttccgatgt tcaaatagga gatgtcttga ttttatctca
     1981 aggaaatgaa attctgtttg atggacaagt agtttcaggt ttaggtatgg tcaacgaaag
     2041 ttccttgaca ggagagagtt ttccagttga aaaaagagag tctgatttgg tttgtgcaaa
     2101 tacagtatta gaaactggag agttacgcat tcgtgtaaca gataatcaga tgaacagccg
     2161 tattttacag ctgattgagt tgatgaagaa atctgaagaa aacaagaaaa cgaaacaacg
     2221 ctatttcatc aagatggcgg ataaagtcgt caaatataat ttcttggggg ctgggctgac
     2281 ttacctattg acaggttctt tttctaaggc tatttctttc ctattggtcg atttctcctg
     2341 cgctttgaaa atctctactc ctgtagctta tttgacagtt atcaaggagg ggttgaaccg
     2401 tgaaatggtg attaaggatg gagatgttct ggagaaatat ctggaagttg atactttctt
     2461 gtttgataag acaggaacaa tcacaactag ttatcctata gttgaaaagg tgttaccttt
     2521 tggagactat agtgaggaag atattctcag aatcagtgcc tgtcttgagg aacacattta
     2581 tcatcctatt gctaatgcca tcgtcaagca agctgagata gagggaattg aacatgagga
     2641 aatgcatggg aaactccaat atatcgcaag caaggggatc aaatctcata tagatggcca
     2701 accagttctt attgggaatt atgtcttgat gcaggatgag cagattcata tcagttcaga
     2761 acaaaatgct ttaattgaag agtacaagag tcactacaat ctcttattct tggcttatca
     2821 aaatgaattg attggaatgt tctgcattca tactcctttg agaaaagaag caaaaacagc
     2881 cttggataaa cttaaggcac aggggaaaaa attgattctg gcaacaggag acaccttgat
     2941 taggacagag gaattagtca aagatttgcc ctttgatcag gtctatacag acttgaaacc
     3001 tgatgggaaa tttgagttag tagagaaact gcagaaagca ggtcacacta ttttgatggt
     3061 tggagatgga ttgaatgact cagcggcttt aactctatca gatatcggtg tggtgatgaa
     3121 tgagagtgca gatatttcta agcagatgag tgatatctta ttgttagata atcgtttgga
     3181 tttcttccaa gagttggatt cgttatcatc atctttgcaa acactcatca agaaaaatat
     3241 tcaagatacc gttgtcgtaa atagtagttt gattggcttt ggcttattta attggttcag
     3301 tccttcaaat ctctctatct tacataatct aacaaccttg cgcattgtct tgcgtagctt
     3361 gtctattaaa aatagataga tgagagttat taacagcaaa aaggagttac ctttctcgag
     3421 gttaactcct ttgtttatag ataaatgttg aatagtttag taagtcaata caaagtattt
     3481 tttcttccca cgacggataa cagtcagttc attttctaac ttatcagcgt cactcaagac
     3541 atagtcaagg tcttggatgc ggtcgccgtt tacgtagatg gctccgtttt ggacgtcttc
     3601 acgggcttgg cgttttgagt taactatacc agatgagacg agcagttcca cgatattgtt
     3661 gttttcgtct gcctgtactt ggtagtttgg cacaccacga agtccttgtt tgagctcttt
     3721 gacagaaagg tttttgatgt ttcctgcaaa gagttgctca gtgatgttaa gtgcttcttt
     3781 gtaggcttct tctccgtgaa caagtgtaac aacttcacga gccaagactt tttgagccaa
     3841 gcgttcgtgt ggcgctgctt caaattgttt acgaatatct tcaatctcat caagtgacaa
     3901 gaaagtaaag attttcaaga agcgaacagc gtcagcgtcc atcacgttca tccagaattg
     3961 gtacatttcg tatggagaag tcttttcggg attgagccag acggcatttc cttctgattt
     4021 accaaatttt ttaccagttg catctgtgat tagtggaaca gtgataacgt gaccagtctt
     4081 gtccgcctta cgacgaagca attcggtacc agctgtcata tttccccact ggtcagaacc
     4141 accgatttga agagtgacat tatggtcttg gttaaggacg aagaagtcgt acccttgcat
     4201 gatttggtaa gcgaactcag tgtaagaaat tcctgtttcg atccgttttt taacagattc
     4261 cttactcatc atgtagttga ccgtgaagta ttttccaatg tcacggagga agtcaatgaa
     4321 gctgatgctg ccaaaccagt cgtagttgtt gaccatgaca gccttgtttt cgccattttc
     4381 aaagtcaaga aaacgagaaa gttgtccttg gatagacttg acccagccat ctactgtgtc
     4441 ttttgtttgg agactacgtt cagcatcttt gaaggacgga tctccgatga gacctgtagc
     4501 accgccaacg agcgcataag gtttgtgacc tgctagttgc aagcgacgac ttgtcaagat
     4561 tgcgacaagg tggcctaggt gaaggctgtc agcagttgga tcgtagccag tataataaga
     4621 aacttgacct tcttctaggg ctttacgcaa agcttcttca tcagtcgttt gaaatatcaa
     4681 accacgctct tttagctcat caaaaatgtg catgtgtctt ttctcctttt taaaattatt
     4741 gtttctacct attgtatcac aaacttgggc aatagcctag cagaataggg aagaaagtgg
     4801 ctattttatt gaaaatttcc cttttgtggt ataatagata aagtgaggaa atccatgcaa
     4861 aatcaattaa atgaattaaa acgaaaaatg ctggaatttt tccagcaaaa acaaaaaaat
     4921 aaaaaatcag ctagacctgg caagaaaggt tcaagtacca aaaaatctaa aaccttagat
     4981 aagtcagcca ttttcccagc tattttactg agtataaaag ccttatttaa cttactcttt
     5041 gtactcggtt ttctaggagg aatgttggga gttgggattg ctttggggta cggagtggcc
     5101 ttatttgaca aggttcgggt gcctcagaca gaagaattgg tgaatcaggt caaggacatc
     5161 tcttctattt cagagattac ctattcggac gggacggtga ttgcttccat agagagtgat
     5221 ttgttgcgca cttctatctc atctgagcaa atttcggaaa atctgaagaa ggctatcatt
     5281 gcgacagaag atgaacactt taaagaacat aagggtgtag tacccaaggc ggtgattcgt
     5341 gcgaccttgg ggaaatttgt aggtttgggt tcctctagtg ggggttcaac cttgacccag
     5401 caactaatta aacagcaggt tgttggggat gcgccgacct tggctcgtaa ggcggcagag
     5461 attgtggatg ctcttgcctt ggaacgcgcc atgaataaag atgagatttt aacgacctat
     5521 ctcaatgtgg ctccctttgg ccgaaataat aagggacaga atattgcagg ggctcggcaa
     5581 gcagctgagg gaattttcgg tgtagatgcc agtcagttga ctgttcctca agcagcattt
     5641 ttagcaggac ttccacagag tcccattact tactctcctt atgaaaatac tggggagttg
     5701 aagagtgatg aagacctaga aattggctta agacgggcta aggcagttct ttacagtatg
     5761 tatcgtacag gtgcattaag caaagacgag tattctcagt acaaggatta tgaccttaaa
     5821 caggactttt taccatcggg cacggttaca ggaatttcac gagactattt atactttaca
     5881 actttggcag aagctcaaga acgtatgtat gactatctag ctcagagaga caatgtctcc
     5941 gctaaggagt tgaaaaatga ggcaactcag aagttttatc gagatttggc agccaaggaa
     6001 attgaaaatg gtggttataa gattactact accatagatc agaaaattca ttctgccatg
     6061 caaagtgcgg ttgctgatta tggctatctt ttagacgatg gaacaggtcg tgtagaagta
     6121 gggaatgtct tgatggacaa ccaaacaggt gctattctag gctttgtagg tggtcgtaat
     6181 tatcaagaaa atcaaaataa tcatgccttt gataccaaac gttcgccagc ttctactacc
     6241 aagcccttgc tggcctacgg tattgctatt gaccagggct tgatgggaag tgaaacgatt
     6301 ctatctaact atccaacaaa ctttgctaat ggcaatccga ttatgtatgc taatagcaag
     6361 ggaacgggaa tgatgacctt gggagaagct ctgaactatt catggaatat ccctgcttac
     6421 tggacctatc gtatgctccg tgaaaagggt gttgatgtca agggttatat ggaaaagatg
     6481 ggttacgaga ttcctgagta cggtattgag agcttgccaa tgggtggtgg tattgaagtc
     6541 acagttgccc agcataccaa tggctatcag accttagcta ataatggagt ttatcatcag
     6601 aagcatgtga tttcaaagat tgaagcagca gatggtagag tggtgtatga gtatcaggat
     6661 aaaccggttc aagtctattc aaaagctact gcgacgatta tgcagggatt gctacgagaa
     6721 gttctatcct ctcgtgtgac aacaaccttc aagtctaacc tgacttcttt aaatcctact
     6781 ctggctaatg cagattggat tgggaagact ggtacaacca accaagacga aaatatgtgg
     6841 ctcatgcttt cgacacctag attaacccta ggtggctgga ttgggcatga tgataatcat
     6901 tcattgtcac gtagagcagg ttattctaat aactctaatt acatggctca tctggtaaat
     6961 gcgattcagc aagcttcccc aagcatttgg gggaacgagc gctttgcttt agatcctagt
     7021 gtagtgaaat cggaagtctt gaaatcaaca ggtcaaaaac cagggaaggt ttctgttgaa
     7081 ggaaaagaag tagaggtcac aggttcgact gttaccagct attgggctaa taagtcagga
     7141 gcgccagcga caagttatcg ctttgctatt ggcggaagtg atgcggatta tcagaatgct
     7201 tggtctagta ttgtggggag tctaccaact ccatccagct ccagcagttc aagtagtagt
     7261 tctagcgata gcagtaactc aagtactaca cgaccttctt cttcaagggc gagacgataa
     7321 ttctctaaat gaagtggcca atcaatggat tgccactttt ttcctttcgt gttacaataa
     7381 gggtatgaat cagtatcaga aaaagattgt taacggaaaa atttattcgc tcctatccgg
     7441 cttaatatgg ggaatctgtg gaattttagg agagtacttc tttactcatt atcaggtgtc
     7501 ttcgggctgg attacctcta tgcgtttgac actggcaggg agtcttgtac tcatttggtc
     7561 tgcaatacaa ttaaaatcgc aagtgctaga tatttggcga gacaagaaaa attacctgcc
     7621 ctttttagcc tatgctattt tggggatttt ttcagttcag tattttttct atctctgtgt
     7681 agaatactca aatgctacga cagcaactat tttacagttt attagccctg tctttatcct
     7741 cttttacaat cgcttggttt atcaaaaacg agcgtcaaaa agcgctgttt tctatgtttt
     7801 ggttgccatg ctgggtgttt gcttgatggc gacaaaggga gatctctctc agttatccat
     7861 gacgccgcta gctcttataa caggtttgct gagtgccatg ggtgttatgt ttaatgttat
     7921 cttgccccaa ccttttgcta agcgttatgg ttttgttcct acggttgggt gggggatgat
     7981 tttggcaggt ttgtttagca atgtcctctc gccggtttat cagctttcct ttactcttga
     8041 tatttggagt atcttgattt gcctcattat cgctttcttt ggaacggctt ttgctttttt
     8101 catttccatg aaggctgtgt ccttggtttc tcctttggtg gttgccgtta tcagtgccag
     8161 tgaacctctc tcttctgctc tcttgagtgt tttgttctta ggattagtag tggattggtc
     8221 cctccttcta gctatagcct tgattatttt acccatgata tttttgtcta tagaagaagc
     8281 gaaagaaagt agataaaaag tcttttctta attctaaaag tgtgctatac tagaatagtc
     8341 aataaaacac ggggagatag ttgtgaagag tgtttttagg ttgtatcggt aggggcttgc
     8401 ttttaccgac agcacgtttt atctcacatc cctaaaaaat catacctaaa aacagacaaa
     8461 aaggtttcaa atttgaggcc ttttttggta gaataggtat cattataacg aaccaggagg
     8521 cacctatgac tgctacaaaa atgaacgctc aagaaattat ccaatttatc gccaatgctg
     8581 aaaagaaaac cagtgtcaaa gtaacctttg aggggcaact cgcaactgct gtgcctagct
     8641 ctgttgtcaa actaggaaat gtcctattcg gagactggaa ggacgtggct ccgcttcttg
     8701 aaggtttggt agaaaatcaa gattatgttg tcgagcaaga tgctcgtaat tctgcagttc
     8761 ctttgctaga taagcgtgct atcaacgctc gtatcgagcc aggtgctatt atccgtgacc
     8821 aggtggaaat tggtgacaat gctgttatca tgatgggagc tgttatcaat atcggtgctg
     8881 aaatcggtgc tggaaccatg attgacatgg gtgccatcct tggtggccgt gccatcgttg
     8941 gaaaaaatag ccacgttggt gcaggtgcag ttttggcagg tgtgattgag ccagctagtg
     9001 ctgaaccagt ccgtgtcgga gacaatgttc ttatcggtgc taatgcagtg gttatcgaag
     9061 gagtccaaat cggtagtggt tcagttgtcg cagcaggagc tattgttacc caagatgtcc
     9121 cagaaaacgt ggtagtagca ggtgttccag ctcgtattat caaagaaatt gatgcccaaa
     9181 ctcaacaaaa aacagcgcta gaggatgcgc ttcgtacctt gtaattgtaa aagtaaaaaa
     9241 gaggcggaac cctttttcca gcctctttct gctatatcgg aggacagata gatgttagat
     9301 ttgattcaga ctagacgaga tttacaccag attccagaga ttggcttgga ggagttcaag
     9361 actcaggctt atttgctgga tgtgattgag aaattgacta cgggcaagga ttttgttcaa
     9421 attcgtactt ggcggacagg gattttggtc tacctgcagg gaagtcagcc ggagcgaacc
     9481 attggttggc ggacagatat tgatggcctg cctatcgtcg aacaaacagg tctacttttt
     9541 gcttctcaac accaaggtcg catgcatgcc tgtggtcatg attttcatat gaccattgcc
     9601 ttaggctgtc ttgagcgcgc tcttgaggag caacccaaga ataatctgct ctttctattt
     9661 cagcctgctg aagaaaatga agctggtggt atgctcatgt atgaggacgg tgcttttgga
     9721 gattggttgc cagatcaatt ctatggtctc catgttcgtc cagatttgaa agtcggccag
     9781 attgcgacta atactcatac actctttgca ggaacttgcg aggtgaagat ccgtttcaaa
     9841 ggcaaaggtg gccacgcagc ttttcctcat gaagccaatg acgccttggt ggtggctagt
     9901 tactttgtga cccaagtgca gtcagttgtt agccgcaatg tcaacccaat cgagggagca
     9961 gtggtgacct tcggcgtttt tcaagctgga accaccaaca atgtcatcac agacacagct
    10021 tttttacatg gaactattcg tgccttgaca caggacatga gtctcttggt gcaaaagagg
    10081 gtaaaaacag ttgcagaagg ggttgcagct gcctttgata tggaagtcga agtggaactc
    10141 aaacaaggtg gatacctacc tgttgagaac aatccagcct tggcgcgtga actgatggac
    10201 ttctttgacg aaaaagacgg aatcgagttg attgatatcg aacctgctat gacaggcgag
    10261 gactttggtt atctcctttc aaaggttgat ggcgtgatgt tttggctagg tatcgatagt
    10321 ccctacgctc ttcatcaccc tcaaatgagt cctaaggaag aagtcttagc tattggggtg
    10381 gctgcggtgt ctagtttcct gaaaaagaag gcagcagaat agagggcttg tatatgaaat
    10441 cggaattacg caagcaagtc ttgcatgaaa tgaaggcttt atctcaagaa caaaaacagg
    10501 ctatagacca agctttaacc gagcgaattt tacaacaccc cttttatcaa gaagccaagg
    10561 tcatcgcaac ctacctctct ttttctcatg agtttcaaac gcgggaactg attgagcagg
    10621 cgctgaagga cggcaagaag gttttaatac ccaaaactta tcccaagggg cgcatggagt
    10681 ttgtggtcta tgatccgcaa cagttggtaa aaacttcctt tgccttactg gagccacagg
    10741 gagatttgga agtggtggat gtatctcaga ttgatttgat tcatgttcct ggcctggctt
    10801 ttacgacgga tggatatcgg attggatatg gtggaggtta ttatgaccgc tatctggaac
    10861 atttttctgg tcgtactttg agtacggttt atccttgtca aattcaggac tttatacctg
    10921 aaaaccatga tattcctgtt caggaggtat taattgatga aggaaatctt tgatagacgt
    10981 taccctgtga cgagtttctt cctcttagtg acggccttgg tatttttact aatgttggtc
    11041 actgcaggcg gaaactttga cagggcagat acattatttc gatttggagc catgtatggg
    11101 ccagctattc gcctctttcc cgagcagatt tggcgtctct tgtctgccat ttttgttcat
    11161 attgggtggg aacatttcat tgttaatatg ctttcacttt attatcttgg aaggcaggta
    11221 gaggagattt tcggttctaa gcagtttttc tttctctatc ttttatcagg aatgatgggc
    11281 aatctctttg tttttgtatt tagtcctaaa tccttagcag caggcgcctc tacctctctt
    11341 tatgggctat ttgccgcgat tatcattctt cgctatgcaa cgcgtaatcc ttatattcag
    11401 cagttgggcc aatcctatct gacacttttt gtggttaaca ttattggaag tgttctgatt
    11461 ccaggaatca gcctagcagg ccatatcggt ggtgcagttg gtggcgcatt tctagcagtt
    11521 atctttccag ttagaggaga aaaacggatg tataacacca gccagagatt aggagcggta
    11581 gtcttgttcg taggactcgc cattttgctt ttctacaagg gaatgggaat gtgacgaagt
    11641 tgaaagaaaa tttgtgtaat gaaaaaagat aaggcatttt ttgaacctta tctttttatt
    11701 ttattccttc tcagtcaatt cttttccaag ttggatgagg taattcttca aatcatcttt
    11761 gacttgtggg tgtttgaggg cgtagtcgat ggatgttttc atgaagccaa acttgtctcc
    11821 gacatcgtaa cgagcccctt tgaactcacg agcaaataca cgttgtgttt tattgagggt
    11881 gtcgattgca tctgtcagct gaatttcatt tcctgcacct ggagcttgct tttcgagaat
    11941 ctcaaaaatt tcaggcgtga ggaggtagcg tccgataata gcaaggtcgc taggagcgtc
    12001 ctctggagct ggtttttcaa caaaggtttc aacactgtaa agaccatctt ttccttcgcc
    12061 ttgcggagca ataaccccgt aagcagatac ttcgtcatga gggactggca tgacagcgat
    12121 agtagacgcg tgggtacgct cgtagtcatc catgagttgt ttggtaagtg gaacagcctt
    12181 ttcgtctgtg atatccatca agtcatcacc aagcataacg acaaaaggtt catttccgac
    12241 gaaagccttg gcttgcaaaa cagcatctcc gagaccgcgt ggatgagttt ggcggataaa
    12301 atgcagacgc atgccagttg tttcatcaac tagcttcaaa agatctgttt tccctttttc
    12361 tttgaggtta tattccaatt cgaagtttga atcgaagtgg tcctcaatag aacgttttga
    12421 tttaccagtg acaactagaa tatcttcaat acctgatttg agagcctctt ccacgataaa
    12481 ctggatagtt ggtttgtcta cgattggcaa catttctttg gcaagggcct tggttgctgg
    12541 taaaaatcga gttcctagtc cagcagcagg gataactgcc tttctaactt ttgatgtcat
    12601 aaaaatcctt tctatagagg gttaagacca ctcattttct gctttaaatt cattgttcat
    12661 gatgtcataa atggcatctt tgatattggt tccgtgataa ataacttggt aaatagcctg
    12721 tgtaatgggc atatagactc caagttcttg ggctagttca taggctgctc gagtcgttga
    12781 aattccttcg attaccatgc ccatattagc ttctatatca gctagggatt ctcctcgtcc
    12841 gagagcatct ccagctctcc agttacgaga gtggatggaa gttcccgtta cgatcaaatc
    12901 tcccacacca gataagccgc tataggtcaa tggattggcc ccgagtgcta cccctaggcg
    12961 ggtgatttct gctaaacctc gagcgatgat ggctgcctta gcattatcac caaatccaag
    13021 accatgtaaa gctccagcac cgacagcaat aatattttta agagcaccag cagtttcaac
    13081 cccgataaca tccgtattgg tataaagtcg gaagtagtga ttactaaata gctcctgaac
    13141 gtattgagct gtttgtaaat ctttagaagc agcagttatt aaagttaggt cacgcacaat
    13201 ggtctcttct gcatgactag gccctgaaac aacgacgata tcactacgga gatgttcagg
    13261 aatttcttct tcaagaatgg ttgataatcg tttatggcta tcaggttcta atccctttga
    13321 tgcgtgcatg atgataacct tatggtccaa ggtttgtgca acttgctggg caacaagtcg
    13381 tgtcactttt gttgggacaa caaacaaaat cgcatccaca tctttcaatg tttctgctaa
    13441 gtcggtgtag gcaatgatat tttcgtctag aacgacatct ttaaagtagt gcttattagt
    13501 atggtgtgta ttaatttcat tgatttgctc gggaagattt ccccaaatac gtacctcgtg
    13561 tccattgtca tttaagactt gtgaaagggc ggttccccaa gaaccaggcc ccaagacggc
    13621 gacggtttgt ttttccatga tttcctcctt gatagagttc tttctcttat tctatcatat
    13681 tctaggggat tttgcacttg cattactggg gtatggtgga aaaatacaca aaaaccgaga
    13741 cgaagggata aactcttagt ctttagttaa agtgagaaga aatctgatag atagtttgat
    13801 tcagtatatg cttataatag aggtaaacaa ctcaggaggt tcttgtaggt tgcgagagtt
    13861 tggcgaaaaa attaaaagat tacgtttggc taaaaaaatc agtcgttcag aattttgtgg
    13921 tgatgagtct gaattaagta tccgtcaatt aattagaatt gaaaatggag aatccagacc
    13981 aacactaaca aagttaaaat atatcgctga acgtttgggg gttgaggatt acaagttgat
    14041 gccaagttat atagagttgg ataaggaata cctagaattg aagtatttct tgatgaggac
    14101 tcctacatac gaagatgaaa ctatcgccca aaagaaagag agtgttttga taagattttt
    14161 gaagagtatt atgataggct acctgaggaa gaaagattta tcatcccaaa ttattcatat
    14221 ctggcactaa cgaactacac agttcaaaaa ttaccagaaa agctagttga aatactgtcc
    14281 ttctggtgat tttgcttaat ttctgatgtt agagacataa ttgaggagat ttgtcttgat
    14341 tttttcctaa aaaagggcag actcctccct tggtttgatg ctcgattttt aaaataaggt
    14401 gacttattct gttaggcatg ttttcccctg ccctctagct ctatatggaa cagggagtat
    14461 cagatttatc tggcagattg tatcaaataa ggcttgaaac tgttttgaat aggcatatag
    14521 acttgagaat ttgagaatat gtcgtctagc agtagagaca tattttccgg caatatgaag
    14581 gaagagacgt cgaaaacgct tgatagtcaa ggcctttact tcatcaccag ctagctgctt
    14641 taaaaagagg tagagattat aagccagaca gcccatcatc atacgtactt cattcttaat
    14701 catggtcgaa ctatctgtct tatccccaaa gaatcctgct ttcctttctt tgataaagtt
    14761 ttcagcattc cctcgttcac gatagaattg aaacagctcc tcactatcta cactgcttaa
    14821 attggtcaaa tgaacttttt tacaaccata aaaaagagca cttaatcgta ctcttctctt
    14881 ttaaggatta gttgaattaa ttcaaatcca ctagttctcc tgtttctagg tagactaggc
    14941 gttcacaaat gttagcaatg taatcagcga agcgttccag atgccctatg atataaaggt
    15001 attgtgttcc attgggaatt gaggtttctt ggtctttcat aagtccaatg atttcctttg
    15061 ataaggcata ataatattgg tcaatctgtt catctttttg agcaatacta atagcttttg
    15121 aggcttggtg caaaggaaag gcaaccaata aatcggatag catgctgagg gataatttac
    15181 ccatttggtg taactgttct tcgtcagggg ctagttgatt ttcttttagt tgcaaaacag
    15241 ctttagcaat gcctgccata tggtctccca tacgttcaag gtctgaacaa gaagacatga
    15301 tgctaatcac aaatcgaagg tcagacactt gtggctgctg caaggccaac aaacgggcac
    15361 aggtcaattc gatagcgctt tgaccttggt tgatagcatg atccttattg ataattagct
    15421 ctgccatctc cttgtctttg gaggctaagg ccagtaaggt ttttgaagct gtttcaagga
    15481 caagttgccc tagtcctaaa aaggattgtt ctaattcatg caattctaag tcaaattgat
    15541 ttctcatagg tttttccttc cttatccgaa ccgtcctgaa atatagtctt ctgtgcgctg
    15601 atcttttgga ttggtaaaca cgtcaacggt gtctccaaat tcgcaaattt ctcctgttaa
    15661 gaaaaaagca gttttatctg aaatacgtga agcttgttgc atgttatggg taacaatgat
    15721 aatcgtataa tcctttttta gttgctgaat gaggtcttca atttttaaag tggagatagg
    15781 gtctaaggct gaagtcggct catccattaa cagaacatca ggttctactg ctaaagctcg
    15841 cgcaatgcaa aggcgttgct gctgaccgcc tgataaggac atggcactct ttttaagatc
    15901 atctttgact tcgtcccaaa tggctgcccc ttttaaagat ttttccacta aggcatctaa
    15961 ttgttttttg tctcgaatac catgtgtcct tgggccataa gccacgttat catagataga
    16021 catggcaaag ggattaggct gttgaaaaac catccctaca cgcttgcgta gctgattaag
    16081 gttgaatttg ctactataaa tatcttgctc atctaagagg acttggcctt caatatggca
    16141 agaaggaacc aaatcgttca tccgattaag ggtttttaga aaagttgatt taccacaacc
    16201 agatgggcct atcaaggcag taatctgtct ttctggtaat tgaatcgaaa tattttttaa
    16261 ggcttgaaaa tccccgtaaa ataagtctag gtgtctgact gaaaatgttc ccatactagg
    16321 aagctccttt cacaagtttc cgagataatg agcttgatag agtatttatc attaaaacag
    16381 taataatcaa aatcacgccg gtagcatagg cttcattgac atgtagcccc tcacttgaca
    16441 gcatatacat atgtagggct agagaacggc ctgaagacat gagactactt ggcgtattgg
    16501 tagaggtacc taatgtatac atgagggcag ctgtttcacc aacgatacgg ccaatagcta
    16561 gtatcactcc agctaaaata cctggcatgg caactggtag aacaattcta aaaacagtcc
    16621 gtaacttacc tgccccaagt ccataacttg cttgacgcat gctatcacta acagataaaa
    16681 gggcttcttc tgttgagcga ataatgactg gcaacaccat gataactgag gttaagattc
    16741 ctgataacag agagtattga aaacctaaga agactacaaa gaagagcatg ccaaacagac
    16801 caaaaacaat ggaaggaatc ccagataagg tatctgaggc caatcgcatg attttaacac
    16861 aaagggaatc tttttttgta tattccacaa gataaaaacc agcaaaaatc cctatgggca
    16921 aggctaaaag aagagcacca aagaccagaa taacggtgga aataatcgct ggcataaggg
    16981 aaatgttctc agaagtataa gtccaagaaa agagggatag acttagatga ggtaagcctt
    17041 tgatgaggat aaaaccaatg attaaaaaga gagagccaaa ggttaaagct gaaaaacaat
    17101 aaacgagaag ttttagcagg tatttactca taagatgatt ttcctttcaa gtaggcaaag
    17161 taggcattaa tcaagagaat aaggaaaaag agaactgctg aggttgcaat aagggcttcc
    17221 ctatgctgac ctgatgcgta agccatttcc agaacaatat tggttgttaa ggttctggtt
    17281 cctgaaaaga gtccacttgg aataatcggc tggttgcctg ccaccaaaat aactgccatg
    17341 gtttcaccta ctgcgcgacc gattcctaaa ataactgctg ataaaatacc agatctcgca
    17401 gctggcaaga tgacactaaa aatactccgt tcatgactag ctcctagagc caagctacca
    17461 gaataatacg ttttgggaac tgttcggata gcagattctg acaaactgat aatggttggc
    17521 aaaatcatta ttcctaatag taacgaagcg gttaggacac tcatgccatt tcctaaaaag
    17581 cttctaatcc aaggcaccaa taattgtagg ccgaaaaaac cataaacaat agatggaatg
    17641 gccgccatca agttgatagc tgattttaag aagccataga cgggctttgg acaataataa
    17701 accataaaca ccgatgtcaa gatgcctgtt ggcaccccaa tcacaatcgc tcctaaggta
    17761 attaataagg aaccaacgat cattggtaaa ataccatagc ttgccggaat gttcgttggc
    17821 gaccaatcac tgcctaataa aaaacgggca aagccgtagt tagccatgaa aggtaagcca
    17881 ttactaaaaa taaagaaaca gattagcaaa atagctacaa cagctactgt tgcactcatg
    17941 aaaaaaattg ccctaaaaac tgcttctttg aaggcttgtt ttatcacatc ttgtcctttc
    18001 tagtgaagaa agtaagggag atacgacacc tccctacttg ccttctttat cttattgtac
    18061 gatgaaacgt ctgcatctct ttagagattt atggagcaaa cattttattt aatcttgtcc
    18121 caggtggtta atttgccact aaaaacgtct gcaagttcag ccatactgac ttggcttgcc
    18181 ttattgtcat tattgaccac aacagcaata ccgtctaaag caatagcatc atgggtgaga
    18241 ctcttacctt cttcaggagt taattcccta gaaaccatac caatatcagc ggttttctcc
    18301 ttaacagcgg taatacctgc tgaagaccca ttagaggtaa tatcaatcgt aacttctgga
    18361 ttttcttttt tataagcttc tgctaatttt tccattaaag aagatactga agtggaacct
    18421 acaacagaca acttgcctga taagtgttgg cttgtatatt ctgtggtttc ggttttagct
    18481 tcaataaatt tattatctgt gaccacttgt tgaccttgtt tggagtggat aaagctgata
    18541 aaatcttgac ctagcttgga aagattagaa gaccaaacaa tgttgaaggg acgttgaaga
    18601 gggtattcac catctaaaac tgtgtctcga ctagccttga caccatcaat ctctaaagcc
    18661 ttgacagatt tcgttaaaga tcccaaggag atgtagccga tagcattagc attcccttga
    18721 actgctgaga gaacaccttc tgtactattt tgaatcacag ctgttttggc agtgttgtca
    18781 atttttttat caccgtcttt tttgagaatc cctgtgattt ctgtgaaggc accccgtgtt
    18841 ccagagccat tttctcgtga aatcacctca atcgttcctg aagctgactg tttggaagca
    18901 gctgactgat tgccacaggc aacaagccca aatcctgata agccaatggc tgcaagagta
    18961 agcatttttt tgaatttcat aataatcacc tttatctcta tgtatttttc ttgtgtaggc
    19021 ttactacatt tatagtctaa caagtctttg taaaggttta tccctgattc atgtaaagat
    19081 tgtgtaaaga atcaaaaaaa gccacttttg aaaaatggct gctcctaaaa atagctttaa
    19141 aaattattag tcctgtgcga aagattggtt aggaagaaaa atcgtgaagc aactgcctct
    19201 gccaagctga ctcgtcaccg tgacttggcc acctaataat tgactgagtt ctttgacaat
    19261 ggcaaggcca agaccagtgc caccagtttg tctgcttcga cctttattaa ctcggtaaaa
    19321 acgttcaaaa atacgatcct gctctaattg actaatacca atccctgtat ctgatacaga
    19381 aatcttaatg ccttcgttca ccttttgggt cttgacctca attttccccc cttgttcagt
    19441 gtaacggatg gcattggata aaagattgag taagatttgg gaaagtaatt gactatctga
    19501 tacgagggtg acatcatctg gcacctgcac ctttagctgt aaatccttct tcttgagctg
    19561 aggttgcaag ctttgagtca aatcctgtac aaattctgcc aaagaaaggg tcgtccattg
    19621 tataggcatt tgttgagcct tagataaggt aagaagatgc tcaacaatat gctcaagacg
    19681 caaactttct ttgtaaataa tgtctagaaa gtcatccttg agcgcttctt cttcagctga
    19741 catcccctta atggtttcag caaagccctt aatcgaagta actggtgtcc tcaattcatg
    19801 ggaggcattt gagacaaagg ctaaatttaa cttttcataa gttctaatcg ttgttaaatc
    19861 atatagcaag acgagcacag cttccacaga ttgggtgggg ctaaaaacgg gaactgctgt
    19921 cacttctaaa atcaagtcac cctcatgaaa cccacttact tcttgtttta accttgtttt
    19981 ttgatcaaag gcttggtgaa ctaaattccg aatatccatc cgtttgaggt catcaagtga
    20041 acttatgtcg ccgtccacat cgggaaaata atgaggcaga gagcgactgg ataataacat
    20101 ctgaccttga gcggaaacta aaaacgtccc catggttagg tgtgacagaa gaacctccat
    20161 tgtttcggct agatccttgt attgctgatc ctgttgggag actttggttt ttaggccaga
    20221 cacatactga gccaaagact ttaagtcttc ttgccctttt tctaaaaagt attcactact
    20281 ggtcaagaga ggttggtgca aggtctcaaa agcaacttcc catttccaaa ggcaaaagag
    20341 ccagtagcca cctagtccca aagaaagggc tagaagaaag agaccgatgc ctttactgat
    20401 ccaagttaat gccatccctg caatcagaat gaggctaaca cttagattga ctagccaaaa
    20461 ttgaaggtag cgtttcatct ataactcctt gaacttataa ccataacccc gaatggttcg
    20521 aataaattga ggggctttag gattgtcttc aattttttcc ctcaacttac caatatgaac
    20581 gtccaccaaa cgtgtttcct gcccaaagtc atacccccag atacgttcca aaagacgctc
    20641 tctagtcagt gtcatgttgg gatgtttcat aagatagagc aagagttcaa attcttttgg
    20701 ggtcaaactc agtaacttat tcgccttgta gacttcatga cgctcagggt atactttcaa
    20761 ggtcccaaat agccaagaat cgtcagcgat attatctgaa tcatctcctt cttgttctcc
    20821 tttagttcgc ctgaggacag ccttgacacg cgccagcaat tctctagggc taaaaggctt
    20881 ggtcaggtag tcatcagccc ctaattccaa ggccaaaacc ttatcaaatt catcactttt
    20941 cgcagaaacc atcataattg gagttttgac gcctttggct ctcagccgct tacaaacttc
    21001 catgccatct aattgtggta acatgatatc aagcaagata aaatcaaagg gttctgtttc
    21061 tgccaaagct aaggccttcc gtccatttgt caccaattga gtagaaaagc cttccttact
    21121 taaatggtag tcaagcaatt tcagaatgtg ttcttcatca tccactaata agacttgttt
    21181 tgtcatctat tatctcctat tggtaacatt ataacacaat tatcagaaat cctaacattg
    21241 ctaaatcaga ttaaatttgc ctatcaagac tagtatctgg tcaaacgctc aatcatctcc
    21301 ttgtgctctg gataggtcgc cagtagatct accctttcaa ataattcaaa atcctcaaat
    21361 tcaaaaccag gagcaacaag acaagaaacc agagcatcat ccttatcaac tgttgatccc
    21421 caaatagtgc ccttaggaac acagtagtga agttgttgcc ctttggatat gtccaggcct
    21481 aaagtgactg cttcgtagtg accatctgct gtaatcatgt gaacagtaag tggggatcct
    21541 gcatgaaaat accagatttc atctgctgtc aatcggtgaa aatgtgaagg attcgtttct
    21601 tctaataaga aataaatact ggtataaagc gcccttccct taccagcaag gtttatagtg
    21661 tctgaagctt tttttgtttg tctaaaatag ccaccttcaa catggggagc taactctaga
    21721 gttcttatca agtcttcttt atccgtcgga gccaatgggt tgaagtaact cttgttcaaa
    21781 gtggtgttac gatttcaaga actcctctca gctctgagga cacggtaatg
//
LOCUS       DBERMM010000033        20746 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.033, whole genome shotgun sequence.
ACCESSION   DBERMM010000033 DBERMM010000000
VERSION     DBERMM010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 20746)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20746)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20746
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.033"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(21..1376)
                     /gene="rlmD"
                     /locus_tag="ACL8AS_001508"
     CDS             complement(21..1376)
                     /gene="rlmD"
                     /locus_tag="ACL8AS_001508"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HGS1229346.1"
                     /translation="MNLKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYC
                     QITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQ
                     ALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELK
                     DCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNR
                     QLNLTQLVKELVKDFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLNYEFSL
                     SPRAFYQLNPEQTEVLYSEAVKALDVSKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDI
                     IPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLL
                     DTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKK
                     V"
     gene            1414..2190
                     /gene="recX"
                     /locus_tag="ACL8AS_001509"
     CDS             1414..2190
                     /gene="recX"
                     /locus_tag="ACL8AS_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000705102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006282 - regulation of DNA repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HGS1229347.1"
                     /translation="MKITKLEKKKRLYLMELDNGDKCYITEDTIVRFMLSRDKVISEE
                     ELKEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDKNIVSQVIANLKEDKW
                     INDGQYAYAIINANQLSGDKGPYVLTQKLAQKGISKSTIEEILNDFDFSEVAQRVANK
                     LLKKYEGKLPARALQDKIIQNLTNKGFSYSDAKIAFDDLDSQVDQETTQELIFKELDK
                     QYTKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL"
     gene            2279..2812
                     /locus_tag="ACL8AS_001510"
     CDS             2279..2812
                     /locus_tag="ACL8AS_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF402 domain-containing protein"
                     /protein_id="HGS1229348.1"
                     /translation="MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDH
                     TLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYI
                     DYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFS
                     EAYVNIWYKRYVELKNR"
     gene            complement(3168..3599)
                     /locus_tag="ACL8AS_001511"
                     /pseudo
     CDS             complement(3168..3599)
                     /locus_tag="ACL8AS_001511"
                     /inference="COORDINATES: protein motif:HMM:TIGR01716.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Rgg/GadR/MutR family transcriptional regulator"
     gene            complement(3686..4024)
                     /locus_tag="ACL8AS_001512"
     CDS             complement(3686..4024)
                     /locus_tag="ACL8AS_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1229349.1"
                     /translation="MKNYGEAFRYFRKLNGYSLEYAAADFISKSQLSRFERGENEISL
                     STFFELLSNINVSIENFCNHLEYYKRSERDDFLVNLSPNFYSLNIKGLEVIKNKQQKL
                     FEKSGKKLIK"
     gene            complement(4037..4810)
                     /locus_tag="ACL8AS_001513"
     CDS             complement(4037..4810)
                     /locus_tag="ACL8AS_001513"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HGS1229350.1"
                     /translation="MIDKVIEQYKSHDNLDIRVELHKKYSKNKLGFNNWIFSNYQITD
                     EVKVLELGCGTGELWKSNSDSIDKMKQLIVTDFSKDMVKSTKSVIGNRNNVNYEIMDI
                     QKISFENETFDIVIANMLLHHVNDIPKALSEVNRVLKTGGIFYCATFGENGVVNYLAS
                     LFKDEVNQDLENRTFTLQNGKRYLSRYFNSVDTLLYDDELQVTSIDDLVKYIQSFKGI
                     SEIGSLEEEIIRKRLESEFNNGMLIIPKEYGMFIARKES"
     gene            complement(5256..6011)
                     /locus_tag="ACL8AS_001514"
                     /pseudo
     CDS             complement(5256..6011)
                     /locus_tag="ACL8AS_001514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000567550.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase QueH"
     gene            complement(6149..7771)
                     /gene="groL"
                     /locus_tag="ACL8AS_001515"
     CDS             complement(6149..7771)
                     /gene="groL"
                     /locus_tag="ACL8AS_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166362.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0140662 - ATP-dependent protein folding
                     chaperone [Evidence IEA];
                     GO_process: GO:0042026 - protein refolding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HGS1229351.1"
                     /translation="MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFG
                     SPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREG
                     IKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYI
                     SEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYI
                     LITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKA
                     PGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGA
                     GNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKL
                     RIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQ
                     IAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVA
                     SLILTTEAVVANKPEPVAPAPAMDPSMMGGMM"
     gene            complement(7787..8071)
                     /gene="groES"
                     /locus_tag="ACL8AS_001516"
     CDS             complement(7787..8071)
                     /gene="groES"
                     /locus_tag="ACL8AS_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HGS1229352.1"
                     /translation="MLKPLGDRVVLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQG
                     VRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE"
     gene            complement(8341..8736)
                     /locus_tag="ACL8AS_001517"
     CDS             complement(8341..8736)
                     /locus_tag="ACL8AS_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HGS1229353.1"
                     /translation="MYNKVIMIGRLTSTPELHKTNNDKSVARATIAVNRRYKDQNGER
                     EADFVNMVLWGRLAETLASYATKGSLISVDGELRTRRFEKNGQMNYVTEVLVTGFQLL
                     ESRAQRAMRENNAGQDLADLVLEEEELPF"
     gene            complement(8814..9575)
                     /locus_tag="ACL8AS_001518"
     CDS             complement(8814..9575)
                     /locus_tag="ACL8AS_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HGS1229354.1"
                     /translation="MAKNVVITGATSGIGEAIARAYLEQGEDVVLTGRRIDRLEILKS
                     EFAVSFPNQTVWTFPLDVTDMVMVKTVCSDILETIGRIDILVNNAGLALDLAPYQDYE
                     ELDMLTMLDTNVKGLMAVTRCFLPAMIKVNQGHIINMGSTAGIYAYAGAAVYSATKAA
                     VKTFSDGLRIDTIATDIKVTTIQPGIVETDFSTVRFHGDKERAASVYQGIEALQAQDI
                     ADTVVYVTSQPRRVQITDMTIMANQQATGFMIHKK"
     gene            complement(9608..10234)
                     /gene="ytpR"
                     /locus_tag="ACL8AS_001519"
     CDS             complement(9608..10234)
                     /gene="ytpR"
                     /locus_tag="ACL8AS_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtpR family tRNA-binding protein"
                     /protein_id="HGS1229355.1"
                     /translation="MIFTYNKEHVGDVLMVIVKNSGDAKLNVERKGKVARVFLKDNGE
                     TVAWNIFEVSSLFEIAERGQVFLSDEQVARLNQELQAEGFTEEIVNDKEPKFVVGEIV
                     EMVAHPDSDHLNICQVAVASDKIVQIVAGAPNARVGLKTIVALPGAMMPKGNFIFPGE
                     LRGEKSFGMMCSPRELHLPNAPQKRGVLELSEDQVVGTPFDPAKHWTA"
     gene            complement(10250..10567)
                     /locus_tag="ACL8AS_001520"
     CDS             complement(10250..10567)
                     /locus_tag="ACL8AS_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HGS1229356.1"
                     /translation="MIQPASLEELASLVEKAGKKVFLFVADWCGDCRYIYPALPEIEE
                     TNPEFTFIRMDRDQYMDLAKLWDVYGIPSLVVLEKDKEIGRFVNRDRKSKEQINDFLA
                     GLK"
     gene            complement(10564..10863)
                     /locus_tag="ACL8AS_001521"
     CDS             complement(10564..10863)
                     /locus_tag="ACL8AS_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4651 domain-containing protein"
                     /protein_id="HGS1229357.1"
                     /translation="MNGMKAKKMWMAGLALLGIGSLALATKKVADDRKLMKTQEELTE
                     IVRDHFSDMGEIATLYVQVYESSLESLVGGVIFEDGRHYTFVYENEDLVYEEEVL"
     gene            complement(11061..11141)
                     /locus_tag="ACL8AS_001522"
     CDS             complement(11061..11141)
                     /locus_tag="ACL8AS_001522"
                     /inference="COORDINATES: protein motif:HMM:NF039231.3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229358.1"
                     /translation="MASSGKMLRNTYTPDGYYVGNLGAWQ"
     gene            complement(11148..11339)
                     /locus_tag="ACL8AS_001523"
     CDS             complement(11148..11339)
                     /locus_tag="ACL8AS_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein"
                     /protein_id="HGS1229359.1"
                     /translation="MYYSVDDVVSNAFKKRMILDSFFAFNCSGTMKVSTWVYDKGEWY
                     YVSSSGSMIANDWVKDNGK"
     gene            complement(11500..12174)
                     /locus_tag="ACL8AS_001524"
     CDS             complement(11500..12174)
                     /locus_tag="ACL8AS_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229360.1"
                     /translation="MKKKAFGIVLLVLAAWILLQGNFGIPSLDGKIWPLLGIVFFAYK
                     SIESILRRHLTSAVFTGLLALIIANYAYDLLPVTNHSLIWASILVVLGVGYLTHSSKF
                     WNEKKWWYNGKKTVVTDKEVAFGSGTFYKQDQDLVDDQVEVAFGDAKIYYDNAEMLGD
                     FATLNIEVAFGNATVYVPQHWRVDLKVETSFGAAKADAPVAPTSKTLIIHGDVAFGKL
                     EIVYAK"
     gene            complement(12180..12626)
                     /locus_tag="ACL8AS_001525"
     CDS             complement(12180..12626)
                     /locus_tag="ACL8AS_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="HGS1229361.1"
                     /translation="MKLRIEIDGNLEETEIVIKTPTLTDEIADLQRLLQESKAPRLTF
                     YKGTGEYYLDLSEILFFETEGSKIYAHNQKEAYEVRLKLYELESILPRYFNRVSKSTI
                     ANIRQIYSVDKSFSGTGTISFYQTHKEVHVSRHYQSLLKENLRNMR"
     gene            complement(12740..13243)
                     /locus_tag="ACL8AS_001526"
     CDS             complement(12740..13243)
                     /locus_tag="ACL8AS_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HGS1229362.1"
                     /translation="MKNYQEWYRNIRSRLTSRPILLFLLRSFNRLMTVAMPLVYLILL
                     VTTYLQLGLGQQVGVYVLIPASGFVALSLFRKKINHPRPYETWDICPLLDKDSSGRSM
                     PSRHVFSATIISMACLHASLPIGLVCLIFSALLGLVRVLGGVHYPKDVLVGYACGLVW
                     GFLFFLF"
     gene            complement(13240..13602)
                     /locus_tag="ACL8AS_001527"
     CDS             complement(13240..13602)
                     /locus_tag="ACL8AS_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2200 domain-containing protein"
                     /protein_id="HGS1229363.1"
                     /translation="MSQKLYNMKFAAVYLALIAKVERKGGKAESVHQVTSWLTGYEVS
                     DVLACLDRDVTYGDFFRQAPYYVPERIAITGKICGVRIEEIDDPLMQEIRRLDKLVDW
                     LAKGKTSQQVLEKYEKHK"
     gene            complement(13668..14699)
                     /locus_tag="ACL8AS_001528"
     CDS             complement(13668..14699)
                     /locus_tag="ACL8AS_001528"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000506433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229364.1"
                     /translation="MGFLLMGALFIVLPRTMVSAKRINQVLDLHSSIQNPVQVQLTDE
                     NFKGQVEFKDVTFRYAANSEAVIEHVSFKAETGQTVAFIGSTGSGKSTLVNLIPRFYD
                     VSAGEILVDGVNVQDYDFSATAHAGQKVAIVGPTGTGKTTIVNLLMKFYEIDKGSIHI
                     DGVDTKAMTRSEVHDAFSMVLQDTWLFEGTIRDNLIYNQIGISDERMMEASKAVGIHH
                     FIMTLPDGYDTILDDTVTLSVGQKQLLTIARALLKDAPLLILDEATSSVDTRTEELIQ
                     KAMDRLMEGRTSFVIAHRLSTIRNADLILVMKDGNIIEQGNYEELMAQGGFYADLYNS
                     QFTEDEAEE"
     gene            complement(14706..15527)
                     /locus_tag="ACL8AS_001529"
                     /pseudo
     CDS             complement(14706..15527)
                     /locus_tag="ACL8AS_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601671.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(15544..16015)
                     /locus_tag="ACL8AS_001530"
                     /pseudo
     CDS             complement(15544..16015)
                     /locus_tag="ACL8AS_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360543.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
     gene            complement(16139..16855)
                     /locus_tag="ACL8AS_001531"
     CDS             complement(16139..16855)
                     /locus_tag="ACL8AS_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HGS1229365.1"
                     /translation="MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESN
                     SALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSN
                     VNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDD
                     VEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKL
                     YSVLEDDEDVQKIYTNVDGF"
     gene            complement(17736..19151)
                     /gene="ply"
                     /locus_tag="ACL8AS_001532"
     CDS             complement(17736..19151)
                     /gene="ply"
                     /locus_tag="ACL8AS_001532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cholesterol-dependent cytolysin pneumolysin"
                     /protein_id="HGS1229366.1"
                     /translation="MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFV
                     VIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSID
                     LPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQ
                     LKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTV
                     TVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQT
                     EWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTS
                     FLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVL
                     TPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRK
                     RTISIWGTTLYPQVEDKVEND"
     gene            complement(19162..19572)
                     /locus_tag="ACL8AS_001533"
     CDS             complement(19162..19572)
                     /locus_tag="ACL8AS_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229367.1"
                     /translation="MIKRGDVVALYLPFPTISSDLAVKNHMYICIDNSMTKNKELVKN
                     QTFKPALLTRRLVKNFMIEEPDLARNPFTRPTLIDLDKVFMLDNTVIPTSYLARRRRN
                     VSEELYEEILDYLVQPRLISLNKSEFMQLNPGTY"
     gene            complement(19565..20173)
                     /locus_tag="ACL8AS_001534"
     CDS             complement(19565..20173)
                     /locus_tag="ACL8AS_001534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229368.1"
                     /translation="MSQSSYLSPLLWLKKEADKEKMSATQCQIFFFYYQMFELLFARE
                     SDMKDLCLGTKGFYFSQLEKNLLSGVSRFLKNLEGKVTLKANQEVSARKALFLALTTS
                     QSDWQELAPVFDFYQTIGRLENPSLLSSQDRQHLMWIYQSALEKDYIVKVIGDKHFVL
                     KRQDATKLTARQTQTLEILSQSEDLVNPVYVTLGEKGVLLLD"
     gene            complement(20186..20644)
                     /locus_tag="ACL8AS_001535"
     CDS             complement(20186..20644)
                     /locus_tag="ACL8AS_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000186958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4231 domain-containing protein"
                     /protein_id="HGS1229369.1"
                     /translation="MTPEEMYLTERLDVQIAHFLKKSVQHRRRYKVLKITEIVAGFLI
                     AVFCAIPMPGDRYRLISVALSSLGLLCEGIINLYNAKENWISYQKTAQLLEKEKFLYQ
                     CQTEKYAGKTKAFALFVKTCEGLISEEINQWESIQSKEVAASADAPVKKE"
BASE COUNT         6223 a         4514 c         3599 g         6410 t
ORIGIN      
        1 atgttttgtc aacacctttt ttaaactttt tttattaatt ttacaacagc ttcagttcga
       61 gctgtatgtg ggaacatatc gaccgactga atataatgaa gatcatagac ttctactaag
      121 cgtaccaaat cacgagccaa ggtcgaaaca ttacaagaaa tataaaccat tttttctggt
      181 acataagtaa gaatagtatc taataactta tcatccagac ctgtacgtgg tgggtcaaca
      241 atcaaagcat ctgctcggta gccttccttg taccaacgag gaataatctc ttctgccgtt
      301 ccagcttcat aatgagtatt gtcaaatccc attcttttag catttcgctt ggcatcttca
      361 atagcttctg gaataatatc catacctctg agtgttttta ctttctttgc aaaggcaaaa
      421 ccaattgttc caactccaca ataagcgtca atcaaatggt cttctttact aacatccagc
      481 gcttttactg cctcgctata aaggacttct gtttgttcag gatttagttg ataaaaagct
      541 cgaggggata gtgaaaattc ataattgagt acaccttctt gaatactctc ttgcccccag
      601 ataatctctg tcttttcacc atatatctca ctggttttag ctgtatttgt attaacagct
      661 actgtcacaa cttctgggaa atctttaacc aactctttta ccaattgagt taaattaagc
      721 tggcggtttg taacaataat aatctgaacc tgtccggtct ttctcgcgcg tcggaccata
      781 atagtacgga cacctagaac ttttctctca tccgtgattg gaatctggtg ataagtaagt
      841 aattctgcta agcgattagc aatcacttgg gtttccttat cttgtaccag gcagtctttc
      901 aactctacta aatagtgaga gttttgtgca tataagcccg ccttgacctg atttttaaat
      961 tttcgggtct gaaattgtaa cttagctctg taatattttg gttcctgcat tccaatagtt
     1021 ggacgaattt cataattttc atatcctgca ggagcaaatt ttttcagcgc ttgatgaagt
     1081 aagtccgtct tgaactccag ctgcttatca taatgcaggt gcatgatttg gcagcctccg
     1141 cattcattat aaatagtaca agatggcaca attcgaaatt tagacttctt gttgaccttc
     1201 agtaattttg cttcaacaaa gttgcgtcta atagaagtaa tctgacaata gatatcttcg
     1261 cctttgagag ctcctggtac aaagactaat gttttttggt aaaagccgat tccctcaccg
     1321 ttaattccca tgcgcttgat ttttaatggt attttttgtt tcactttcag attcataccc
     1381 ctatcttatc acattttgag ttataataga gctatgaaaa tcacaaaact tgaaaagaaa
     1441 aaaagactct atctgatgga gcttgataat ggcgacaaat gctatatcac cgaagataca
     1501 attgttcgtt ttatgttatc gagagataag gtgataagcg aagaggaatt gaaagagatt
     1561 caagactttg ctcaattttc ttatggtaag aatctggccc tctaccactt atcctttaaa
     1621 gcacgcactg aaaaagaagt cagagaatat ctgaaaaaat acgatattga taaaaacatc
     1681 gtttctcaag ttattgctaa tcttaaagaa gataagtgga ttaatgatgg tcagtacgct
     1741 tatgctatca tcaatgccaa tcaactttca ggagacaagg gaccttatgt actgactcag
     1801 aaattagcac aaaaaggaat ttcaaaatct actatagaag aaatcttgaa tgattttgat
     1861 ttttcggaag ttgctcaacg tgtagccaat aaactattga aaaaatatga gggaaaactt
     1921 ccagctcgtg ccctgcaaga taagattatc cagaacttga ctaacaaggg cttctcttat
     1981 tctgatgcta aaattgcctt tgacgactta gatagccaag ttgaccaaga aacgactcaa
     2041 gaactcatct tcaaggaact tgataagcaa tatactaagt atgctcgaaa gtatgaagga
     2101 tacgaactga agcagcgttt aactcaagtt ttagcacgaa agggctacga tttttcggat
     2161 atagcaagcg ctcttagaga atatctttaa tatttccaag tgaaattcac agattttagg
     2221 taattttatg gtacaatagt aaatgataaa cttataaatt gtagaaagtt ggttagttat
     2281 gaagcttcca aaagaaggcg actttattac aattcaaagt tataagcatg atgggagtct
     2341 ccaccgaact tggcgggaca ccatggtact aaaaacaaca gaaaacgcca ttattggtgt
     2401 caacgatcat acacttgtta ccgaaagtga tggtcgtcgt tgggtcactc gagaaccggc
     2461 tattgtttac tttcacaaga aatattggtt taatatcatt gccatgattc gtgataatgg
     2521 aacttcttac tattgcaata tggctagccc ctactatctg gatgaagaag cactgaagta
     2581 tattgattac gatttggatg ttaaaatttt tacagatggg gaaaaacgtc tcttggacgt
     2641 tgaagagtac gagcgtcaca aacgcaaaat gaattattct gatgacttgg actatatttt
     2701 aaaagaacat gtcaaaattc ttgttgattg gattaacaat ggacgtggtc ctttctcaga
     2761 agcctatgta aacatttggt acaagcgcta tgtagaacta aagaatcggt aaagttgtca
     2821 aaggtcagga acaaaatcct gacctttttt ttggtagtat aaaataaatt gtgtaaacac
     2881 aaaaaggaat aaatctatta tagcagagtt acaacacatt actagaaaga gatttataca
     2941 aaattcgtaa aatatataaa acaaatagat atactgttat tttttaatgt ctttattcct
     3001 tgtaagttta caacaaactt atatcgttta atacaaaaaa tacgaaaatg attagtataa
     3061 aaaatacagg tcaacttcgt atcaaaaaca tttttttgta tttccacata gcatcaatca
     3121 tttagtacaa tattttaaaa acaatatctt aacagagaaa atgatattta atctatcagc
     3181 tcatttaatc gtttttgaaa atataaagca atacttttag attcaataaa ctcaaaatat
     3241 tttatgacat tgtccatttg tttaattcca gattctttag attctgtcag gtatatttta
     3301 tatccttcta caaatttgaa tgtagatttt tcaaaaactt ttgtgtcatc ttttaataat
     3361 ttttgtaatt tcatttcaaa gtagtctgca tatattagat gtgaattttc aaggcaacag
     3421 aaccaaaaat ttaaacaagc tgacacaact aaatttctat tcttgccgat tttttcgtaa
     3481 taatgtgtac gctctagtat ttcttttccg accatgtaaa tataatctat ttcaaaaaga
     3541 tgatataaat taccaatcag cgttatctca taggactccc atcgttcctt ctggaataaa
     3601 tagtcatata ctaaatttag atcatctcta ctaactacat gattacaatc tagctgattt
     3661 cataatccct gaaccataat tgtatttatt ttatgagttt tttcccactc ttctcaaaaa
     3721 gtttttgttg cttatttttt attacctcca atcctttaat attcaaacta taaaaatttg
     3781 gagataaatt aaccaaaaaa tcatcacgct ccgatctttt ataatattct aagtgattac
     3841 aaaaattctc tatcgaaaca ttgatatttg ataataattc aaaaaatgtt gaaagagaaa
     3901 tttcattttc tcccctttca aatctagaaa gttgagattt tgatataaaa tcagctgcag
     3961 catactctaa agaatatccg tttaattttc taaaatatcg aaaagcttct ccgtaatttt
     4021 tcacactttc attcccttaa ctttcttttc gagcgataaa cataccatat tctttaggaa
     4081 tgatcaacat accattatta aactcacttt ccaatctttt acgtattatt tcctcttcta
     4141 gtgaacctat ttctgaaatt cctttaaacg attggatgta tttaactagg tcatctatac
     4201 tagttacctg taactcatca tcatagagta atgtatcgac agagttaaaa tacctactca
     4261 ggtacctttt accattttgt aaagtaaacg ttctattttc taaatcttga ttaacctcat
     4321 ctttaaataa acttgccaaa taatttacaa ctccattttc accaaatgta gcacagtaaa
     4381 aaatgcctcc ggtttttaag accctattca cctcagagag agctttagga atatcattca
     4441 catgatgtag aagcatatta gcaataacaa tatcaaaagt ttcattctca aaagaaatct
     4501 tttgaatatc cattatctca taattgacat tgtttctatt tccaatcact gacttcgttg
     4561 attttaccat atctttagaa aaatctgtaa caatcaactg cttcatttta tctatagaat
     4621 cactattact tttccacaat tctcctgtac cacatcccaa ttctagaacc tttacttcat
     4681 cagtgatttg gtagttagaa aatatccaat tattaaatcc caatttattt tttgaatact
     4741 tcttatgcaa ttctactcga atatcaagat tatcatgact tttatattgt tcaattactt
     4801 tatcaatcat tttaaatgac ctccactcta taatttggca ttatatcaca agaataaaga
     4861 tagtgttaaa taagttatat aaatgcaaaa aaggaatatt ccgttatagc agagttgtaa
     4921 cacatttcta taaagaaatt tattcctacg actcagtttg gcatgcttaa cttcctaact
     4981 caaaaacaaa gcatcgatta atttatccgt tcttcttttg aaacagattt gaactgataa
     5041 ttgctcgttt taatttaaaa agctcttttg agcaaaactt cattttttta agagtccaac
     5101 aatttctgtc tatcgctttt ctactagcaa aaaacctacc ttgaggcaag ttttcattta
     5161 tatatctaat ttcgtaacag tatagtaaaa tgaaataagg acagtcaaat cgatttctaa
     5221 caatgtttta gaagtaaagg tgtactattc tagtttcaat ctactataaa tttgatatga
     5281 gaatagtctt tctcaacatc cttatccaac aagcatgctg tggcgtcctt cttaacttaa
     5341 accaggtcaa tattctgggc ttgggctgca tagacgcagc cacaataaca ttgacgatag
     5401 atatcatact cctcacacat ctctactgaa cgtttgtagc cttgattttt cttgaaatcg
     5461 ttgggaagat agtggggcgt gtaaattttt tgcacatcga ttccgatgct attgatagtt
     5521 tgagaattct tatgaggact gatggtcaag gctgaaccaa agtagtcaaa gcccaagtcc
     5581 atagccactt gcgctgtttt atccagtcgg tagtcaaaac aaaccttgca acggtcgcca
     5641 ccttcgggct cctcctctag ccccctaact agttttcggt attaattggg ttcgtaggga
     5701 gcttctaggt actgaaccgt atttcctgtc cgctcattaa aatcactaac aaatttcttg
     5761 gtgacataga cccgcttatg gtattctgcc ttgggatgga tattagaatt ggcaaaatag
     5821 atggtcacat ctgcatactt ggtcaaatat tctagtgtat aggtactaca aggggcacag
     5881 caaacatgca cgagaatggt tggccgctac tcattttttt cccatgcttg taccattttc
     5941 tgcatgacac ggtcataatt aatcttctga ttgggggtca tcttgcacag aatttcttct
     6001 acatcgatca tgttcttctc ctttttctag tcttatttta tcatataagt taggagagct
     6061 caaatcaatt tagaagtgaa tattataaaa agaagggtta gtcattccct ccttttgtgt
     6121 tttttataag ttgttttcta tagaaagctt acatcatccc gcccatcata cttggatcca
     6181 ttgctggagc tggggctact ggttctggtt tattggctac gactgcttct gttgtcaaaa
     6241 tcaagctggc tacagatgct gcattttgta gggctgaacg actcacttta actggatcaa
     6301 tgataccttg atcaatcatg ttaacccact cgccagttgc tgcgttgaat cctataccaa
     6361 gctcagcatt tttcaaacga tcgataacga tagatccttc aaatcctgca ttgtgagcaa
     6421 tttgacgaac aggttcttcc aaagcacgga gaacaatatt acgtcctgtt gcttcatctc
     6481 ctgtcaattc caaggtagca acagctggaa tcacattggc aagagctgtt ccaccacctg
     6541 caacaatacc ttcttcaaca gctgcacgag tagcgttgag ggcatcttca atgcggagtt
     6601 tcatttcttt caactcagtt tcagttgcgg ctccgacctt aataaccgct acaccacctg
     6661 acaatttggc caagcgttct tgcaattttt cacggtcaaa ttcagaagtt gtagtttcga
     6721 tttgagactt gataaccgca acacggtgag aaatcgcttc aggatttcct gcaccttcta
     6781 caataaccgt gctatctttg tccacggtca ctctcgctgc ttgaccaaga gcttcaattg
     6841 tcgcatcttt caactcaaga ccaaggtctt ctgtgataac tgttccgcct gttaagatgg
     6901 cgatatcttc aagcatggct ttgcgacggt caccaaaacc aggtgccttg actgctacta
     6961 cgttgaaggt tccacgaatc ttgttcaaaa caagagttgg aagagcctcg ccatccacat
     7021 catccgcaat aatcaagagt ggacgattgc tttggagaat gctttccaaa agtggcaaga
     7081 tttcttggat attggaaatt ttcttgtctg taatcaaaat gtacggattt tcaaggtcag
     7141 ccaccatttt ttcgctatca gtcaccatgt actgtgaaag gtaaccacgg tcaaactgca
     7201 ttccttctac gacttcaagc tctgtttcca taccacgtga ctcttcgatg gtgatgacac
     7261 cgtctttgcc aactttttcc attgcttcag agatgtactc accaactttt tcagaacgag
     7321 aagatacggc tgcaacttga gcgatagctt ctttattggc aacagggatg gcgttgtttt
     7381 tcaaagcttc aactgctgcg gcaactgctg tttcaatccc acgacgaata ccgattggat
     7441 ttgcacctgc tgtgacattt ttgattcctt cacggacgat agcttgggtc aagactgttg
     7501 cagtcgtagt cccgtcacct gcgatatcat tggttttaga agctacttct gatactaact
     7561 tagcacccat attttcaaaa tggtcttcca attcgatttc tttggcaatg gtcacaccgt
     7621 cattggtaat caagggtgaa ccgaatgact tttcaagaac gacattgcga ccttttggtc
     7681 ccaaggttac tttaacagtg tctgcaagaa tatcgacacc acgaaccatg gctgaacggg
     7741 catctgatga aaatttaatt tcttttgaca tacttacttt ctccttctat tcctcaatga
     7801 ttgccaaaat gttagcttcg cctacgataa tgtacttttc atcgccatct ttgacatcaa
     7861 gacctgcgtg ggcttcaact aagacacgat ctccagtttt aacacttgga gcaaccaagt
     7921 caccgttcaa ggtacgaaca ccttgtccag tagccacaac ttgagctgtt ttggtttttt
     7981 cttgggctga gcctgcaagg acaaagcccc caacggtttg ttctttttct tctattttta
     8041 agaccacacg gtcccctaat ggtttcaaca tctgatttcc tccataatga gatagatatt
     8101 attagcactc tttgaactgg agtgctaatt cataattcta ttgtatcact tggtcagaaa
     8161 tagtcaagaa aaaagtctga ctttctcaag ataaaaagcc tgagaccaac tcagactttt
     8221 taatgtttat actcaatgaa aatcaaagag caaactagga agctagccgc aggctgctca
     8281 aagcattgct ttgatgttgt ggataaagct aacgtggttt gaagagattt tcgaagagta
     8341 ttaaaatggc aattcttcct cttccaagac taaatctgcc aaatcttggc ctgcattatt
     8401 ttcacgcatg gcacgttgag cacgactttc caagagttgg aatcctgtta caagtacttc
     8461 ggtcacgtag ttcatttggc catttttctc aaagcgacgg gtacgcaatt ctccatcaac
     8521 ggaaatgaga ctacctttgg ttgcgtagct tgccaaagtt tctgctagtc tgccccatag
     8581 gaccatattg acaaaatcag cttcacgttc accgttttgg tctttgtaac gacggttgac
     8641 agcgatagtt gctcgcgcta ccgacttgtc attgttggtt ttgtgcaatt ctggtgtaga
     8701 cgttaaacgc ccaatcatga taactttatt atacatattt tcttcctcct acttatctat
     8761 tcgtaggaaa tcaaaaaaag ttacagaaat ttgtaacttt tcgaggaaat ttcttatttt
     8821 ttatgaatca tgaaacctgt cgcctgttga ttggccataa tggtcatatc tgtaatctga
     8881 acacggcgag gctgactggt cacatagact actgtgtctg caatatcctg agcttgcaag
     8941 gcttctattc cttggtaaac ggacgcagct cgctctttat caccatgaaa acgaacagtt
     9001 gagaaatctg tttcgacaat cccaggctga atggttgtca ccttgatatc cgttgcgatg
     9061 gtatcaattc gcagtccatc cgaaaaggtc ttaaccgcag ccttggtagc tgagtaaaca
     9121 gcggcaccag cataggcgta gattcctgcg gttgacccca tattgataat atgaccttga
     9181 ttgactttta tcattgctgg caagaaacag cgagtaaccg ccatcagacc tttaacattg
     9241 gtatccaaca tggtcaacat atccaactcc tcatagtctt gatagggagc caagtcaaga
     9301 gccagtccgg cgttgttgac caagatatca atcctcccta tcgtttctag aatatcagag
     9361 caaacagtct tcaccatgac catatccgtc acatctagtg gaaaagtcca gacggtttga
     9421 tttggaaagc ttactgcaaa ctccgacttg aggatttcta atctgtctat ccgtcgtcct
     9481 gttagaacga catcctcacc ctgctccaga taagcacgcg caatcgcttc accgattcct
     9541 gaggttgctc ccgtaatcac tacatttttt gccatcttat ttccttctat cagatgctga
     9601 caagttccta ggcagtccag tgtttcgctg ggtcgaacgg tgttccgaca acttggtctt
     9661 ctgataattc aagcacccca cgtttttgcg gagcatttgg caaatgcaat tcacgaggac
     9721 tacacatcat cccaaaactc ttttcaccac gaagttcgcc tgggaaaatg aaattccctt
     9781 ttggcatcat ggcaccagga agagccacaa tggttttcaa cccaacacgc gcattaggtg
     9841 ctcctgcaac gatttgcact atcttgtcac ttgcgactgc aacttggcag atgttgaggt
     9901 ggtcactgtc tggatgagct accatctcga caatttcacc aacaacaaac ttaggttcct
     9961 tatcattaac aatttcttct gtaaaacctt ccgcctgtaa ttcttggttc aaacgagcga
    10021 cttgctcatc tgataaaaag acttgaccgc gctctgcaat ttcaaacaag ctcgaaacct
    10081 caaaaatgtt ccaagctact gtttccccat tatctttgag aaaaacacgg gctaccttgc
    10141 ctttgcgttc cacattcagt ttggcatctc cgctattttt cacgatgacc ataaggacat
    10201 caccgacatg ttctttgtta tacgtaaaaa tcattgtttc ctttttctcc tatttcaatc
    10261 ctgctaaaaa atcgttaatt tgctccttac ttttacggtc gcgattgaca aaacgaccga
    10321 tttccttgtc cttttctaga acaacaaggc taggaattcc gtaaacatcc cagagtttgg
    10381 ccaaatccat atactgatct cggtccattc gaataaaggt gaactctgga ttggtctctt
    10441 caatctctgg taaggcagga taaatataac gacaatcgcc acaccagtct gccacaaaaa
    10501 ggaagacctt cttgcccgct ttttccacta aagatgctaa ttcttctaaa cttgctggct
    10561 gtatcataag acttcctcct catagactag gtcttcattt tcatagacaa aggtataatg
    10621 acggccatcc tcaaaaatga cgccaccaac caagctctcc agactgcttt cgtaaacttg
    10681 aacataaagg gtcgcaattt cccccatgtc ggaaaaatgg tctcgcacaa tctctgtcaa
    10741 ctcttcctga gtcttcatga gcttacggtc atctgcaact tttttcgtag caagagcaag
    10801 gcttccgata cctagcagag ccagacctgc catccacatt tttttagctt tcataccatt
    10861 cattttaaca caaaaaaggc ttcaggacaa atgaggaagc agcagaaaag caagtaaaaa
    10921 gcctcttcct ttaaggaaaa ggacttctta tactaagagc aaactagaaa gctagccgca
    10981 ggctgctcaa aacacggttt tgaggttgta gataaggcga cgctgacgtg gtttgaagag
    11041 attttcaaag agtattattc ttattgccag gcacctaagt tgccaacgta gtaaccatca
    11101 ggtgtgtagg tattgcgaag catcttacct gatgaagcca gataatacta cttgccattg
    11161 tctttgaccc aatcattcgc aatcatggaa ccagaagaac ttacataata ccattctccc
    11221 ttgtcataaa cccaagtact gactttcatg gttcctgagc aattaaaggc aaaaaaactg
    11281 tccaatatca ttcgtttttt aaaagcattt gacactacat catctacgct gtagtacata
    11341 gatacatcaa acgtaaaagc caaaatatcg aaaaatatac aacttttaaa ggcagcattt
    11401 cattttttaa agtctaacaa ccatagaact gaaatcagag caaggcatca atttcctact
    11461 cttagtacgc ctattttgat ggttgaagtg aagatttttt tatttagcgt agacaatttc
    11521 caacttccca aaagccacat ctccatggat aatcaaggtt ttgctggttg gggctacagg
    11581 agcgtcagcc ttagctgcac caaaggaggt ttctactttc aaatctacac gccagtgttg
    11641 tggaacatag acggttgcat tcccgaaggc cacttcaata tttaaagttg caaaatcacc
    11701 tagcatctct gcattatcat agtagatttt agcatcccca aaagcgactt ccacttggtc
    11761 atctacgaga tcttgatctt gcttatagaa ggtcccgcta ccaaaagcga cttccttatc
    11821 cgtgacgact gtttttttcc cattgtacca ccattttttt tcattccaga acttacttga
    11881 atgcgtcaga taaccaacac caagtaccac caagatgcta gcccaaataa gagaatgatt
    11941 ggtaactggt aacaagtcat aagcgtaatt tgcaatgatg agcgccagta aacctgtaaa
    12001 aactgccgaa gtgagatgac gtctaaggat ggactcaatg gacttataag caaaaaaaac
    12061 aatacctagt aaaggccata ttttaccatc caaagaagga attccaaaat tcccttgcag
    12121 caagatccaa gctgctaaaa ccaataaaac aataccaaat gctttctttt tcatgttttt
    12181 tacctcatgt ttcttagatt ttcttttagg agggattggt aatgccgtga gacatgaacc
    12241 tccttgtgcg tctgataaaa ggaaatggtg cccgttcctg aaaaggactt gtccactgag
    12301 taaatctgac ggatgtttgc gatcgttgac ttggaaactc gattaaaata gcgaggcaag
    12361 atagactcca actcatagag cttgaggcga acctcataag cttccttctg gttatgagcg
    12421 tagatcttgc tcccttctgt ttcaaagaag agaatttctg acaggtctag ataatattca
    12481 cctgtcccct tgtaaaaagt caacctcgga gcctttgact cttgcaagag ccgttgcaag
    12541 tctgcaattt catctgtcaa agtgggggtc ttgatgacaa tttcagtctc ctctaaattg
    12601 ccgtcaatct caattcgtaa cttcatcaca tctcctttct gactctacta tatcaaagct
    12661 aagttaggaa tacaagggca aaaaagcaag tggtcaattt gaagcagtaa gtggttgtag
    12721 gactagctta acttacatgt cagaatagga agaaaaggaa tccccacacc aaaccacaag
    12781 catagccaac caagacatcc ttgggataat gaacaccccc taaaaccctc accaacccca
    12841 gcaaagctga aaagatcaag catactaagc caataggtag actagcatgc agacaggcca
    12901 tggagatgat agttgccgaa aagacatggc gactgggcat cgaccgtccc gaactatcct
    12961 tatcaagaag gggacagata tcccaagttt cataaggtct cgggtgattg attttcttac
    13021 gaaacaggga caaggccaca aaacctgatg caggaataag cacataaacc ccaacttgct
    13081 gaccaagtcc tagttgcagg taagtagtga ctagcaagat cagatagacc aggggcatgg
    13141 cgactgtcat caaacgattg aaactgcgta ataggaataa aagaattgga cgactagtta
    13201 gtctggatct gatatttcga taccattctt gataattttt catttatgct tctcatactt
    13261 ttctagaact tgttgagatg ttttcccctt ggcaagccaa tccactagct tgtccaagcg
    13321 acgtatttcc tgcatcagag gatcatcaat ttcctcaata cggacaccgc aaatcttccc
    13381 tgtaattgca attcgttcag ggacataata tggtgcttgt cgaaaaaaat ctccgtaagt
    13441 aacatcccta tccagacaag caagaacgtc actcacttca taccctgtca accaactggt
    13501 cacttggtga actgactctg cctttccacc ctttcgctca acttttgcaa tcaaggctaa
    13561 gtagacagca gcaaatttca tattgtataa tttctgactc atacttctct ctttctatgt
    13621 gtactagtat aaataagaaa aagaaggccg tcaagccttc ttttgattta ttcttctgct
    13681 tcatcttctg taaattgact attgtacaag tcagcgtaga agccaccttg cgccatcagt
    13741 tcctcatagt tgccttgctc gatgatattt ccatctttca tgaccaagat caagtctgca
    13801 tttcggatgg ttgacaagcg gtgggcaatg acaaaggatg tgcgtccttc catcaaacgg
    13861 tccatggctt tttggatcaa ttcctctgtc cgtgtgtcaa cagaagaagt cgcctcatcc
    13921 aaaatcaaaa gcggtgcatc cttaagaagg gcacgagcaa tagtcaatag ttgtttttgt
    13981 cctacagaca aggtcacggt gtcatccaag atggtatcat agccatctgg caaggtcata
    14041 ataaagtggt gaattcccac agccttacta gcttccatca ttcgttcatc actaatccct
    14101 atttgattat agatgagatt gtctcgaata gttccttcaa agagccaggt atcctgcaag
    14161 accattgaaa aggcatcatg cacttctgaa cgcgtcatag ccttggtatc cacaccatca
    14221 atgtgaatac ttcccttatc aatctcatag aatttcatca aaagattgac aatggttgtc
    14281 ttaccagtcc cagtcggccc aacaatggca accttttgac cagcatgagc tgtcgcagag
    14341 aagtcatagt cttgaacatt gacaccgtcc accagaattt ctcctgctga cacgtcgtag
    14401 aaacgtggaa tcagattgac cagagttgat ttaccagaac ctgttgaccc aataaaggcc
    14461 actgtttgac cagtttctgc tttaaagcta acatgttcaa taactgcctc cgaatttgcc
    14521 gcatagcgga aggtcacatc cttaaactcg acctgacctt tgaagttttc atcagtcagc
    14581 tgcacttgaa cagggttttg gatagaagaa tgcaaatcta aaacttgatt aatccgctta
    14641 gcagagacca tagttcgggg aagaacgatg aagagtgctc ccatgagaag gaagcccatg
    14701 acaacctaca tggcataaga catgaaaaca atcatgtcac taaagagagg cagacgcgct
    14761 atcggagcag cgtcgttaat cacataggcc ccaatccagt aaatcgctac actcaaacca
    14821 cttgaaatcc ccatcatgat aggattcaaa atagccataa gacggttgac aaacaaattc
    14881 aaacgggtca attcatcatt tactgctgca aatttttcat tttgataatc ctctgcattg
    14941 taggcacgaa cgacacgaat acctgttaaa ctctcacgag tgatactgtt cagtttatct
    15001 gtcaacccct gaatcaagga ctgttttgga aaggctagcg tcatcaaaac ggtcgtcatc
    15061 aggacgttga caatcactac cacaagtacg gcccagagtc agtattctga atgacctaaa
    15121 atcttcccaa tagcccagat agccataatt ggaccacgcg ttaccacttg caagcccata
    15181 gtaatcaaca tttgaacttg agtaatgtca ttggtagtac gcgtcaagag gctaggaatt
    15241 gaaaatttct taatctctgt ctgcgagtaa tccaaaactc ggttaaaaat atcacttctc
    15301 agcctactag tataagaagc cgccactcgg gatgcaaaaa atccaactgc aactacggac
    15361 aagaaggcaa gaaagagcat tcccatcatc atgcttgccg gctgccacaa ctcatctaaa
    15421 ttagtttctt gactacctag caaatccgta attttcgaga tataggtcgg cacttccaac
    15481 tctagataga ccgaaaagca agtaaagaga atggctagta aaatcatccc ccattctttt
    15541 ctactaattc ttttggttaa tttctttatt ctctcctcct attcccttga tattttgcct
    15601 gtagttgacc gagaactttc tcaaaaatca gtaattcatc ttcatcaatg tcttccatca
    15661 actgcttgtc tatgcgttca aaaaaagcct taacctgttg catctgagaa cgtgctttgt
    15721 ccgtcagacg aacaaactta gcccgcttat caacaggact cgcctccaat tccaccaaac
    15781 cattttgcac tatacgctta accagattac tagcaacaga cttggtaata ttgagttcct
    15841 gctcgatatc tttaatcaag accaagtctt ggtttttcta gcgattatcc aaaaaacgca
    15901 caacctgacc ttgcggccca cccataaatt caatgccgca acgtttggct tccttttgca
    15961 ccatcaggta aatttgatga ccaaaacgct taaagactaa catcggttta tccataatct
    16021 cccccttcta aataaaaata gttctctgga gaataattaa atttctatga gaactatttt
    16081 cttgattaaa aaaatcccaa gtgattttct cacttaggat catgttctat aggttaaatt
    16141 aaaacccatc tacgttcgta taaatctttt ggacgtcttc gtcgtcttca agaacgctgt
    16201 aaagtttttc aaaggtttca aggtcttcgc ctgacaattc cacttctgac tgaggaatca
    16261 tttccaattc agtcacttgg aattcttcaa taccagactc acggagagca acgatagcct
    16321 tgtgaaggtc agttggcgct gtgtaaactg tgattgtacc ttcttgtgct tctacgtcat
    16381 ccacatccac atccgcttcg agcaattgct caaagactgc gtccgcatct tcacctccaa
    16441 atacaataac acctttgttg tcaaaaaggt aagaaacaga acctgaagcg cccatgtttc
    16501 cgccgttttt accaaaggct gcacggacat tggctgctgt acggttaacg ttagaagtca
    16561 aagtatccac aattagcata gagccatttg gcccaaaacc ttcgtaacgt ccttctgtaa
    16621 aggtttcgtc tgtgtttcct ttggctttat caatcgcttt atcgataatg tgttttggca
    16681 cttgggcttg tttagcacgg tcgataacga atttcaaagc tgagtttgat tctggatctg
    16741 gatcaccttt tttagctgct acatagattt ctacaccaaa ttttgcatat actttagagt
    16801 tagctccatc tttagccgtt ttcttggcta cgatattggc ccatttacgt cccattagga
    16861 atctcctttt ttcacatttt aatctttctt attataacac aagttttttt gattttcact
    16921 agaggaaatg gattttatta gcaaatcaag ctaggatagc actttacctg ctaagatggt
    16981 cttgcctttc tatctttatc aacagacact catccacatt caaaaaacaa actagaccat
    17041 tatctgcaaa tagaaagttt cagccaagtt tgacaaagtc agctcaaatt actgtttgaa
    17101 gtttgtagat ataagcgaca aaaacaatca tactgcacct tttgttgaca gtctactcca
    17161 gacatatcat agttcaagta aatactttga aattcaacag ttcttatagg cgctattgta
    17221 ttctaagaaa tcaatagaag agtttctaag caaacctcta atactcaata aaaatcaaag
    17281 agcaaactag aaagctagcc tcaggttgct caaaacactg ttttgaggtt gcggatgggg
    17341 ctgacatggt ttgaagagat tttcgaagag tataatttac gtgttcccaa gatggagaag
    17401 ttagactagt acactggcac ttctaaaaca ttgctagcaa ttgatttgtt catatttaat
    17461 ttcatttttt ccataaatgg gtattagata taaacagcaa aatatttccg atacgtgtcg
    17521 ttcttgaatt tccaatcatc taaaacaagt aaaggataat caatcccctg tatatcaagg
    17581 aattggctac cctttttact tttttacaca ttctgtttga tagattcatt ttaacatcac
    17641 gagcatactc caatggaaat cgctaggcaa gagataaact ttcagatatc cgcagagaga
    17701 tcatcgcctc tttttgtcgc aagcattctc ctctcctagt cattttctac cttatcttct
    17761 acctgaggat agagagttgt tccccaaata gaaatcgtcc gcttacgcac tagtggcaaa
    17821 tcggtttttt cataaaccgt acgccaccat tcccaggcaa gcccggtaca ctctctaatt
    17881 ttgacagaga gattacgaac attccctttt aaaggaatac tagtggtaaa gtgagccgtt
    17941 aaatcctgcc catttctgtc ccaagcctta ggagtcaaga cttccttacc ttgatgatca
    18001 taggataatt cattccaagt aatataatat tgggcaacat aggcaccact atgatccagc
    18061 agtaaatctc cgtttctgta agctgtaacc ttagtctcaa catagtctgt actattttga
    18121 aaggtcgcaa ctacattgtc acgtaaaaaa gaagttgtat aggaaatcgg caagcctgga
    18181 tgatctgctg taaagcgact gccttcttga atcaagtcct ctaccatatc caccttgcct
    18241 gttacaactc gggcacccga acttgggtcg ccccctaaaa taaccgcctt cacttctgta
    18301 ttgtccaaaa tctgcttcca ctctgtctga ggagctacct tgactccttt tatcaaagct
    18361 tcaaaagcag cctctacttc atcactctta ctcgtggttt ccaacttgag atagacttgg
    18421 cgcccataag caacactcga aatatagacc aaaggacgct ctgcagaaat tcctctctgt
    18481 tttaaatcct ctaccgttac agtatcttga aacacatctc ctggattttt aacagcatct
    18541 acgctgactg tataataaat ctgcttaaaa ttaacaatct gaatctgctt ttcgcctgaa
    18601 tggacagagt taaaatcaat atcaagagaa ttccctgtct tttcaaagtc agaaccaaac
    18661 ttgaccttga gttgttccat gctgtgagcc gtgatttttt catactgcat tctagctggg
    18721 acattattga cctgaccata atcttgatgc cacttagcca acaaatcgtt taccgctccg
    18781 cgaacactcg aattgctggg gtcttccact tggagaaagc tatcgctact tgccaaacca
    18841 ggcaaatcaa tactataagt catcggagca cgatcgaccg caagaagagt gggattattc
    18901 tctaacaagg tctcatccac tacgagaagt gctccaggat agaggcgact gtcgttggta
    18961 gctgttacag aaatatcact tgtatttgtc gacaagctcc gcttctttct ttcgataaca
    19021 acaaactcat cgggtagctg attaccctct ttgatgaaac gattttcaat actttctccc
    19081 tgatgggtca agagtttctt tttatcgtaa ttcatagcta gtataaagtc atttactgct
    19141 ttatttgcca tcttctacct cctaataagt tcctggattg agttgcataa actcagactt
    19201 gttcagcgaa atcagccgtg gttggactaa gtaatccaaa atttcctcgt acaattcttc
    19261 tgagacattg cgtcgccgtc tggctaaata agaagtcgga atgaccgtat tatccaacat
    19321 aaatacctta tctaagtcaa tcaaggttgg tcttgtaaaa ggattacgag ctagatccgg
    19381 ctcttctatc ataaagttct tgaccaaacg tctggtcaag agagctggtt tgaaggtctg
    19441 atttttaacc aactctttgt ttttagtcat gctgttgtca atacagatat acatatgatt
    19501 cttcacagcc aaatcgctac taatagtcgg aaaaggcaaa taaagagcta caacatctcc
    19561 tctcttaatc aagcaagagc accccctttt ctcctaatgt aacatagaca ggattgacca
    19621 agtcttctga ttgactcaga atttccaaag tttgagtttg gcgcgctgtc aatttagtag
    19681 catcttgtct cttcaataca aaatgcttgt cgccaataac cttgacaata taatccttct
    19741 ccaaagctga ctggtaaatc cacatcagat gttgtctgtc ctgagaactc aagagagaag
    19801 gattttcaag cctcccgata gtctgataaa aatcaaaaac aggagctaac tcctgccaat
    19861 ctgattggct agttgtcaag gctagaaaaa gggctttgcg agctgatact tcttggttag
    19921 ccttgagagt tactttcccc tccaagtttt ttagaaatcg ggaaactcca gaaagcaaat
    19981 ttttctctaa ctgcgagaaa taaaaacctt tcgttcccag acataagtct ttcatgtcgc
    20041 tttctctagc aaataagagc tcaaacattt gatagtaaaa gaaaaatatc tggcactggg
    20101 tcgcgctcat cttttcctta tcggcttctt tttttaacca gagcaagggc gacaggtagc
    20161 tggattgaga catttcctct acctcctact cttttttaac tggagcatct gcactagctg
    20221 ccacttcttt tgactggata ctttcccact ggttaatctc ctctgagata agaccttcgc
    20281 atgtcttgac aaatagggca aaagccttgg tctttcctgc atatttctcc gtttggcatt
    20341 gatagaggaa tttttctttc tccaggagtt gcgcagtttt ttggtaagaa atccaatttt
    20401 cctttgcatt atacaaattg ataatcccct cacacagcaa gccgagactg gataaggcaa
    20461 ccgaaatcaa acggtagcga tcacctggca taggaatagc acaaaagaca gctatgagga
    20521 aacctgccac gatttctgtt atttttaata ccttatagcg cctacgatgt tgaacgcttt
    20581 tctttaaaaa atgagctatc tgtacgtcta atcgctctgt caggtacatt tcttctggcg
    20641 tcatattcgt aactcctttc atttactttg ataatcatag tataacatat ttgaatatca
    20701 aagtatagta aaaactggac tataacttat tagacttcct gcgaaa
//
LOCUS       DBERMM010000034        20498 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.034, whole genome shotgun sequence.
ACCESSION   DBERMM010000034 DBERMM010000000
VERSION     DBERMM010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 20498)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20498)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20498
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.034"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            132..560
                     /locus_tag="ACL8AS_001536"
     CDS             132..560
                     /locus_tag="ACL8AS_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS N-acetylgalactosamine transporter subunit
                     IIA"
                     /protein_id="HGS1229370.1"
                     /translation="MKIVLVGHGHFATGIYSSLQLIAGNQENVEAIDFVEGMSADELK
                     QKILLAISNEEEVLILSDLLGGTPFKVSSTIMGENPAKTMNVLSGLNLAMLMEAVFAR
                     MAHSFDEVVNKSVVAAQGGVVNGKELFSTDAEEEDFESGI"
     gene            572..1762
                     /locus_tag="ACL8AS_001537"
     CDS             572..1762
                     /locus_tag="ACL8AS_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003074342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="HGS1229371.1"
                     /translation="MIKKVTIEKIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDY
                     FKEDFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYEYSQQDAFKNIAHKNVLSFLDR
                     VNKRVELAHHDLGFLYTPSCMAEYKINGDGEAREAALKAADKLIERYQEKGGFIQAWG
                     DLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHT
                     FYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNY
                     FLNRLPKDHVSYWDLIFNDGSDQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAM
                     HAMLRSLIEYYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDW
                     NLYW"
     gene            1773..2264
                     /locus_tag="ACL8AS_001538"
     CDS             1773..2264
                     /locus_tag="ACL8AS_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000178618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1229372.1"
                     /translation="MTMPNIIMTRIDERLIHGQGQLWVKYLGCNTVIVANDEVSTDKM
                     QQTLMKTVVPDSVAMRFFPLQKVIDIIHKANPAQTIFIVVKDVKDALTLVEGGVPIKE
                     INIGNIHNAPGKEQVTRSIFLGEEDKAALKELSQTHQVTFNTKTTPTGNDGAVQVNIM
                     DYI"
     gene            2279..3058
                     /locus_tag="ACL8AS_001539"
     CDS             2279..3058
                     /locus_tag="ACL8AS_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HGS1229373.1"
                     /translation="MSINVFQAILIGLWTAFCFSGMLLGIYTNRCIVLSFGVGIILGD
                     LPTALAMGAIGELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVSPEAALALST
                     PIAVAIQFLQTFAYTVRAGAPETAMKHLKNHNLKKFKFTLNATIWLFAFIGFTLGCLG
                     ALSMDTLLKLVDYIPPVLLTGLTVAGKMLPAIGFAMILSVMAKKELIPFVLLGYVCAA
                     YLNIPTIGIAIVGTIFALIEFYNKPKTADHVVEEEAHDDWI"
     gene            3045..3863
                     /locus_tag="ACL8AS_001540"
     CDS             3045..3863
                     /locus_tag="ACL8AS_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HGS1229374.1"
                     /translation="MTGSNKLTKRDYLKTSLRAFFCQNGFNYSNYQGLGYANVMYPAL
                     KKHYGEDQEGFYQALEENCEFYNTNPHFLPFITSLHLVMLENGRPAKETRSIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASFAQEGLVVGPILFFLAMNTILTAIKLSTGLYGYK
                     LGTTVIDKLSEQMATISRIANIIGVTVIAGLAATSVKIMVPITFAAGEVKADAKQSIV
                     SIQGMLDKVAPALLPALFTLLVYYLIKEKKWTTYKLVILTVIIGIIGSWLKIIA"
     gene            3863..4156
                     /gene="yajC"
                     /locus_tag="ACL8AS_001541"
     CDS             3863..4156
                     /gene="yajC"
                     /locus_tag="ACL8AS_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000381741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HGS1229375.1"
                     /translation="MDTTLFYGIVIVLAVSPLLLSSFHSIRQQKLLRKQMEQRQEYLA
                     SLTSGDEVLLLSGIHGKIISIKDDLISLQIAKGVVIYVEKESVMGKTKELLFK"
     gene            4178..6079
                     /locus_tag="ACL8AS_001542"
     CDS             4178..6079
                     /locus_tag="ACL8AS_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="HGS1229376.1"
                     /translation="MKEERRQFFERIDGNQCRDYILSHCSKDYEKVKSSLERLMDNRF
                     MFDSPWDMEPCSKIHQIQPMVWDQVFEDDPEWAYMLNRQEYLLQFMIGYVVEGDKDYI
                     QKCKFFLFDWIEQVREFSPQSLMTRTLDTGIRSFTWLKLLLLLLKFDLLEEKELEKIL
                     VSLEKQIDFMKSHYRAKYTLSNWGILQTIPMLAIYYFFSDKMDLEEAYHFASEELKQQ
                     IETQILGDGSQFEQSILYHVEVYKALLDLCLLLPDLQDSYRELLEKMATYIQMMTGLD
                     GRTLAFGDSDSTETTEILSLSAVVLNKEDLLNGLDVKVDLLSLLFLGREKVKRLQEFE
                     KRAWQPKSMIFEDSGHVCIKDEHRYLFFKNGPLGSAHSHSDENSFCLQYQGQPIFIDA
                     GRYSYREIYERYLLKSAWSHSTCIVDGKAPERITGSWEYEYYPHSLFCHHKEREGVHY
                     IEGAYWSAEPDLPYLHKRKILMLVEDVWLLVDDIRCQGQHEALTQFILDKDVTYQDGK
                     INQLRLWSEVDFDLEDTIISPKYNELERSSKLTKRQFFENQMLDYTIIAHESFEIIRH
                     SVYQTDDREVENALAFEVKNDETDKLILLLSEDIRVGEKLCLVDGTKMRGKCLVYDKI
                     NERMIRLQC"
     gene            6139..7140
                     /locus_tag="ACL8AS_001543"
     CDS             6139..7140
                     /locus_tag="ACL8AS_001543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HGS1229377.1"
                     /translation="MEKKLTIKDIAEMAQTSKTTVSFYLNGKYEKMSQETREKIEKVI
                     HETNYKPSIVARSLNSKRTKLIGVLIGDITNSFSNQIVKGIEDIASQNGYQVMIGNSN
                     YSQESEDRYIESMLLLGVDGFIIQPTSNFRKYSRIIDEKKKKMVFFDSQLYEHRTSWV
                     KTNNYDAVYDMTQSCIEKGYEHFLLITADTSRLSTRIERASGFVDALTDANMRHASLT
                     IEDKHTNLEQIKEFLQKEIDPDEKTLVFIPNCWALPLVFTVIKELNYNLPQVGLIGFD
                     NTEWTCFSSPSVSTLVQPSFEEGQQATKILIDQIEGRNQEERQQVLDCSVNWKESTF"
     gene            complement(7250..7585)
                     /locus_tag="ACL8AS_001544"
     CDS             complement(7250..7585)
                     /locus_tag="ACL8AS_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000838135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229378.1"
                     /translation="MKSLARLLIIHVFISIFLFFALISGAVSHTVLLLLLLFLPALNK
                     GLEKIQSKRIPVLNAALFFLLISFPQLLTNPVQWKFSIFLVVTIISSLAYFYNFYQVV
                     KEVDQKQLI"
     gene            complement(7596..7838)
                     /locus_tag="ACL8AS_001545"
     CDS             complement(7596..7838)
                     /locus_tag="ACL8AS_001545"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229379.1"
                     /translation="MKKEKKQLRYPGLKAGSIYGIVIFFIIPLIDTLTSENPNFITSL
                     LNTKHIFKTILGAFFFGVMIHIVDSLRIARAKKDQD"
     gene            complement(7849..8391)
                     /locus_tag="ACL8AS_001546"
     CDS             complement(7849..8391)
                     /locus_tag="ACL8AS_001546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3278 domain-containing protein"
                     /protein_id="HGS1229380.1"
                     /translation="MKKETFTEKLIKRTYGISDPLDEYKRREADRIGNQVFIILFYLM
                     IFGNLIPLLLAYKYPQEVALIYPPLILAIALIAAGYVTYQMKKTGITAIDPDMLSEKE
                     SKQLHYPGLKAGLLYGLMSFFSSPLLHILLGESQDYLQSLLAFKNIFSSILQSFFFGV
                     IIQIIISRRIAKAKKDQDND"
     gene            complement(8407..8601)
                     /locus_tag="ACL8AS_001547"
     CDS             complement(8407..8601)
                     /locus_tag="ACL8AS_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HGS1229381.1"
                     /translation="MNRVKEFRKELGISQLELAKDIGVSRQTINMIENDKYNPTLELC
                     LNLARSLQTDLNSLFWEDDF"
     gene            8768..9718
                     /gene="rsmH"
                     /locus_tag="ACL8AS_001548"
     CDS             8768..9718
                     /gene="rsmH"
                     /locus_tag="ACL8AS_001548"
                     /EC_number="2.1.1.199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HGS1229382.1"
                     /translation="MTKEFHHVTVLLHETVDMLDVKPDGIYVDATLGGAGHSEYLLSK
                     LSEKGHLYAFDQDQNAIDNAQERLAPYIEKGMVTFIKDNFRHLQARLREAGVQEIDGI
                     CYDLGVSSPQLDQRERGFSYKKDAPLDMRMNQEASLTAYEVVNHYDYHDLVRIFFKYG
                     EDKFSKQIARKIEQARDLKPIETTTELAEIIKSAKPAKELKKKGHPAKQIFQAIRIEV
                     NDELGAADESIQQAMDMLALDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPD
                     DLNPKMELVSRKPILPSAEELEANNRSHSAKLRVARKIHK"
     gene            9730..10047
                     /gene="ftsL"
                     /locus_tag="ACL8AS_001549"
     CDS             9730..10047
                     /gene="ftsL"
                     /locus_tag="ACL8AS_001549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsL"
                     /protein_id="HGS1229383.1"
                     /translation="MAERMEKTGQILQMQLKRFSRVEKAFYFSIAVTTLIVAISIIFM
                     QTRLLQVQNDLTKINAQIEEKKTELDDTKQEVNELLRAERLKEIANSKDLKLNNENIR
                     SAE"
     gene            10051..12303
                     /gene="pbp2X"
                     /locus_tag="ACL8AS_001550"
     CDS             10051..12303
                     /gene="pbp2X"
                     /locus_tag="ACL8AS_001550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP2X"
                     /protein_id="HGS1229384.1"
                     /translation="MKWTKRITRFAIRNRKSPAENRKIVGKYISLLAVVLFAVFLVNF
                     AVIIGSGSKFGTDLVKEAKKVHQITRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDE
                     NYKSATGKILYVEKTQFNKVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITY
                     ANMMSIKKELETAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSG
                     MESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQQTVDGKDVYTTISSTLQSFMETQ
                     MDAFLEKVKGKYMTATLVSAKTGEILATTQRPTFNADTKEGITEDFVWRDILYQSNYE
                     PGSAMKVMTLASSIDNNTFPSGEYFNSSEFKIADATTRDWDVNEGLTTGGMMTFLQGF
                     AHSSNVGMSLLEQKMGDATWLDYLKRFKFGVPTRFGLTDEYAGQLPADNIVSIAQSSF
                     GQGISVTQTQMLRAFTAIANDGVMLEPKFISAIYDTNNQSVRKSQKEIVGNPVSKEAA
                     STTRNHMILVGTDPLYGTMYNHYTGKPIITVPGQNVAVKSGTAQIADEKNGGYLVGST
                     NYIFSAVTMNPAENPDFILYVTVQQPEHYSGIQLGEFANPILERAVAMKDSLNLQSTA
                     KTLDQVTNQSAYAMPSIKDISPGDLAEALRRNIVQPIVVGTGTKIKESSVEEGTNLAP
                     NQQVLLLSDKAEEVPDMYGWTKATAEAFSKWLNIELVFEGSGSTVQKQDVRANTAIKD
                     IKKITLTLGD"
     gene            12305..13285
                     /gene="mraY"
                     /locus_tag="ACL8AS_001551"
     CDS             12305..13285
                     /gene="mraY"
                     /locus_tag="ACL8AS_001551"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008963 -
                     phospho-N-acetylmuramoyl-pentapeptide-transferase activity
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HGS1229385.1"
                     /translation="MFISISAGIVTFLLTLVGIPAFIQFYRKAQITGQQMHEDVKQHQ
                     AKAGTPTMGGLVFLIAAVVVSFLLALFSKQLTNNVGMILFILVLYGLVGFLDDFLKVF
                     RKINEGLNPKQKLALQLLGGVVFYLFYERGGDMLSVFGYQVHLGIFYIVFALFWLVGF
                     SNAVNLTDGIDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLGFFVFNHKP
                     AKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIIYVFETTSVMMQVSYFKLTGGKR
                     IFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLM"
     gene            13933..16038
                     /locus_tag="ACL8AS_001552"
     CDS             13933..16038
                     /locus_tag="ACL8AS_001552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HGS1229386.1"
                     /translation="MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEF
                     AHYRATGQLPGNVEVDGRMPQQASSMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEI
                     QETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
                     EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAEDTYKILQGIRDLYQQ
                     HHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREI
                     EAEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTG
                     IPVSQMGASDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLF
                     VGPTGVGKTELAKQLALDMFGTKDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSN
                     TLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVIIATS
                     NAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLA
                     EVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLD
                     AKHLEADMEDGVLVIREKV"
     gene            complement(16334..16816)
                     /locus_tag="ACL8AS_001553"
     CDS             complement(16334..16816)
                     /locus_tag="ACL8AS_001553"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HGS1229387.1"
                     /translation="MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLV
                     QPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAV
                     IKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
                     "
     gene            complement(16911..18395)
                     /locus_tag="ACL8AS_001554"
     CDS             complement(16911..18395)
                     /locus_tag="ACL8AS_001554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HGS1229388.1"
                     /translation="MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHA
                     ARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKF
                     NELGIFVGSVVITQYAGQPAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPEGMG
                     KNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINGIKSGYAKFETFPVWNLPLHH
                     PVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMLERILGKSPYA
                     SPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMND
                     LGITPADRKVAVVARQKAEETGGPALALELPNGDIVTGKNSELFGPTAAALINAIKKS
                     ADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEE
                     LGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK"
     gene            18548..20155
                     /locus_tag="ACL8AS_001555"
     CDS             18548..20155
                     /locus_tag="ACL8AS_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HGS1229389.1"
                     /translation="MQEKWWHNAVVYQVYPKSFMDSNGDGIGDLPGITSKLDYLAKLG
                     ITAIWLSPVYDSPMDDNGYDIADYQAIATIFGTMEDMDQLIAEAKKRDIRIIMDLVVN
                     HTSDEHAWFVEACENPNSPERDYYIWRDEPNDLDSIFSGSAWEYDEKSGQYYLHFFSK
                     KQPDLNWENEKLRQKIYEMMNFWIDKGIGGFRMDVIDMIGKIPDEKVVNNGPMLHPYL
                     KEMNQATFGDKDLLTVGETWGATPEIAKLYSDPKGQELSMVFQFEHIGLQYQEGQPKW
                     HYQKELNIAKLKEIFNKWQTELGVEDGWNSLFWNNHDLPRIVSIWGNDQEYREKSAKA
                     FAILLHLMRGTPYIYQGEEIGMTNYPFETLDQVEDIESLNYAREALEKGVPIEEIMDS
                     IRVIGRDNARTPMQWDESKNAGFSTGQPWLAVNPNYEMINVQEALANPDSIFYTYQKL
                     VQIRKENSWLVRADFELLDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSV
                     LIENTAAKEVLEKQVLAPWDAFCVELL"
     gene            20315..20488
                     /locus_tag="ACL8AS_001556"
     CDS             20315..20488
                     /locus_tag="ACL8AS_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001022221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteinase"
                     /protein_id="HGS1229390.1"
                     /translation="MNIKKRVLSAGLTFASALLLAACGQSGSDTKTYSSTFGGNPTTF
                     NYLLDYYADNIVN"
BASE COUNT         6239 a         3681 c         4637 g         5941 t
ORIGIN      
        1 ctattaaaat gattaaaaag ataatgaaag cgctaatatt tttttaaaaa aactattgac
       61 aagataaaaa taaaggatta caatggggaa tataaagtaa accggtaaac ctaaacaaga
      121 aaggagaaaa gatgaaaatt gtacttgtag ggcatggaca ttttgctaca gggatttata
      181 gttctttaca attgattgca ggcaatcaag aaaatgtgga ggcgattgac tttgtggaag
      241 gaatgtcagc agatgaactc aagcaaaaaa tcttacttgc aatttcaaat gaagaagaag
      301 ttttaatcct aagtgatctc ttgggaggaa cgccattcaa ggtttcttct accataatgg
      361 gagaaaatcc agccaagaca atgaatgttc tctcgggttt gaacttagcc atgttaatgg
      421 aagcagtctt tgctagaatg gctcatagct ttgatgaggt tgttaataaa tcagtagtgg
      481 cggcccaggg cggagtcgta aatggtaaag aattgttttc aacggatgca gaggaagaag
      541 atttcgaatc gggtatttaa agggtaaaag aatgataaaa aaggttacga ttgaaaaaat
      601 aaaatcgcct gagcgcttct tagaagtacc acttctgacg aaagaagaag tcggccaggc
      661 aatcgataag gttattcggc agttagaact caaccttgac tatttcaagg aagatttccc
      721 gacaccagct acctttgata atgtctatcc aatcatggat aacacggaat ggaccaatgg
      781 tttctggaca ggagaactgt ggttggctta tgaatacagt caacaggatg catttaaaaa
      841 catcgctcat aaaaatgttc tttctttcct ggatcgtgtc aataagagag tagaattggc
      901 tcaccatgat ctcggcttct tgtacacacc gtcttgtatg gctgaatata agataaatgg
      961 agatggagag gctagagaag cagccttgaa agctgcagat aagttgattg aacgctatca
     1021 agaaaaaggt ggttttattc aagcttgggg agacttgggc aagaaagagc attaccgttt
     1081 gattatcgac tgcttgctca atatccaact cttattcttt gcttatcaag aaacaggtga
     1141 tcaaaaatac tacgatattg cagaaagcca tttctatgct tcagctaata atgtaatccg
     1201 tgatgacgct tcgtccttcc acaccttcta ttttgatcct gagacaggtc aaccctttaa
     1261 aggtgtaacg agacaagggt atagtgatga ttcatgctgg gcacgtggtc aatcatgggg
     1321 agtctatggt attcctttga cttatcgtca cttaaaagac gagtcctgct ttgacttgtt
     1381 taagggtgtg accaattatt tcttgaatcg tctgccaaaa gatcatgtgt cttattggga
     1441 tttgattttt aatgatggta gtgatcaatc acgagattct tcagcaacag ctatcgccgt
     1501 ctgtgggatt catgaaatgc taaaacatct cccagaggtg gatgctgaca aagatattta
     1561 taaacatgct atgcatgcca tgcttcgttc cttgatcgaa tattatgcaa atgatcaatt
     1621 tacccctggt gggacaagtc tcctccacgg tgtgtactca tggcattcag gtaaaggagt
     1681 ggatgaaggc aatatctggg gtgactacta ttacctagaa gcccttatcc gtttctacaa
     1741 agactggaac ctatattggt aggaggagaa atatgacaat gccaaatatt attatgaccc
     1801 gtatcgatga acggttgatt catggacaag gacaactttg ggtaaaatac ctaggttgta
     1861 atacggtcat tgttgccaat gacgaagtaa gcacggacaa gatgcaacaa actctgatga
     1921 aaacagttgt gccagactca gttgccatgc gtttcttccc tttgcaaaag gtgattgata
     1981 tcattcacaa ggctaatcct gctcaaacga tctttatcgt tgtaaaggat gtaaaggacg
     2041 ctttaacctt ggtagaaggt ggtgtcccta tcaaagaaat caatattggg aacattcaca
     2101 atgcccctgg taaagagcaa gtgacacgct ccatcttcct gggtgaagag gacaaggcag
     2161 ccctcaagga attaagccaa actcatcaag taacatttaa tacgaaaaca actccaacag
     2221 gaaatgatgg agctgttcaa gtcaacatta tggactatat ttaaaagagg agatcgttat
     2281 gtcgattaat gtatttcaag cgattttaat tggactatgg acagctttct gttttagtgg
     2341 aatgctatta ggaatttaca ccaatagatg tattgttctg tcatttggtg tcggaattat
     2401 tctaggtgat ctgcctactg ctcttgcaat gggagctatt ggtgaattgg cttatatggg
     2461 attcggtgtt ggtgctggag gtactgttcc accaaaccca atcggacctg gtatctttgg
     2521 taccttgatg gctatcacta gtgctggtaa agtcagtcca gaagcggctc ttgccctctc
     2581 tactccgatt gctgtggcga ttcaattctt acaaactttc gcctacactg tacgtgctgg
     2641 tgcgcctgaa acggcgatga agcacttgaa aaaccataat ttgaagaaat ttaagttcac
     2701 tctaaatgca acaatttggt tgtttgcctt tattggattt accttgggtt gcttgggtgc
     2761 cctttcaatg gataccttgt tgaaactcgt agactacatt ccaccggtat tacttacagg
     2821 tttgacagtt gctggtaaaa tgctcccagc tatcggtttt gcgatgatct tgtcagtgat
     2881 ggctaagaaa gagttgattc cctttgtctt gttgggatat gtttgtgcag cttatctaaa
     2941 catcccaaca attggtattg caattgtagg tactatcttt gctttgattg aattttataa
     3001 caagccaaaa acagcggatc atgtggtaga ggaggaagca cacgatgact ggatctaaca
     3061 aattaacaaa acgtgattat cttaaaacgt ctttgcgggc attcttttgt caaaatggat
     3121 ttaactatag taactatcaa gggttgggat atgccaatgt gatgtatcct gctttgaaaa
     3181 aacactatgg agaggatcag gaaggtttct accaagcctt ggaagaaaac tgtgaattct
     3241 ataataccaa cccacacttc ctgcctttta ttaccagctt gcatcttgta atgttggaaa
     3301 atggccgtcc ggcaaaagaa acacgtagca tcaagatggc cttgatggga ccattggcag
     3361 gtattgggga ttctctttct caattctgtt tagctccatt gttctcaacc atcgcagctt
     3421 cgtttgctca agaaggcttg gttgtcggtc caatcttgtt cttccttgcg atgaatacga
     3481 ttttaacagc gattaaattg tcaactggtc tgtatggata caaactagga acaactgtga
     3541 ttgataaact aagcgaacag atggcaacga tttctcgtat tgccaatatt atcggtgtaa
     3601 ccgtaattgc tggtttggca gcgacatctg ttaagattat ggtgccgatt acctttgctg
     3661 caggggaagt taaagcagac gctaaacaaa gtatcgtaag tattcaggga atgcttgata
     3721 aggttgctcc agctcttcta ccagccctat ttacactttt agtttactac ttgatcaaag
     3781 aaaagaaatg gacaacatat aaactcgtta ttttaacagt tatcatcgga attatcggaa
     3841 gctggcttaa gattatagct taatggatac aacattgttt tatggaatag tgattgtctt
     3901 ggcagtgagt ccccttttac tgtcaagctt tcattctatt cgtcagcaaa agttgcttcg
     3961 caaacagatg gagcaacgac aagagtattt agcttcttta acatctggtg atgaagtgtt
     4021 gttattgtct ggaattcatg gaaaaatcat ttctatcaaa gatgacttga tctccttgca
     4081 gattgcaaaa ggtgtggtca tctatgtaga aaaggaaagt gtaatgggaa agacaaaaga
     4141 actgcttttt aagtagttct ttttctggta atagataatg aaagaagaaa gaagacaatt
     4201 ttttgaaaga atcgatggaa accaatgtcg tgattatatc ttgtcccact gttcaaaaga
     4261 ctatgagaaa gtcaagagtt cccttgaacg cttgatggac aatcgtttta tgtttgatag
     4321 tccttgggat atggagcctt gttcaaaaat ccatcaaatc cagccgatgg tatgggatca
     4381 agtatttgaa gatgatccag aatgggctta tatgctcaat cgacaagaat atctcttgca
     4441 gtttatgata gggtatgtgg tagaaggaga taaggactat attcaaaagt gcaagttctt
     4501 tctatttgat tggattgagc aggtgagaga attttctcct caatccttga tgactagaac
     4561 cttggatacg ggtattcgtt cctttacttg gttgaaacta ctcttgctcc tcttgaaatt
     4621 tgacttgcta gaggagaaag aactagagaa aattttggtc agtctagaaa agcagattga
     4681 ctttatgaaa agccactatc gcgccaagta cacccttagt aactggggga ttttacaaac
     4741 aattccgatg cttgctatct attatttctt ttcagataag atggacctag aagaagctta
     4801 ccattttgct tcagaggagt tgaaacagca aattgagaca cagattttag gagatggaag
     4861 tcagtttgaa cagtcgattc tctatcatgt agaggtttat aaagccttac tggatttgtg
     4921 tctcttgctt ccagacttgc aagatagtta ccgagagttg ctggaaaaga tggcgaccta
     4981 tattcaaatg atgacaggct tagatggacg aactttggct tttggtgata gcgattctac
     5041 agaaacgaca gaaattttga gcctgtctgc tgtggttttg aacaaggaag accttcttaa
     5101 cggtctggat gttaaagttg atttgcttag cctcttgttc ctggggcgag aaaaggtcaa
     5161 gcgactgcag gaatttgaaa agagagcttg gcagcctaag tccatgatct ttgaagactc
     5221 tggacatgtc tgcattaagg atgaacatcg ttatctattt ttcaaaaatg gtccgctagg
     5281 aagtgcccat agccatagtg acgagaatag tttttgctta cagtatcaag gccaacctat
     5341 tttcatagat gctgggcgtt attcttatcg ggagatatat gaacgttatc tcttaaagag
     5401 tgcttggagt cattcgacct gcattgtaga tgggaaagct ccggaaagaa tcacgggatc
     5461 ctgggaatat gaatactatc ctcactccct gttttgtcac cataaagaaa gggagggagt
     5521 gcattatatt gagggggctt attggtcagc agaacctgat ttgccttatc ttcacaagag
     5581 aaaaatcctc atgttggtag aggatgtctg gctcttggta gatgacatca ggtgtcaagg
     5641 tcagcatgag gcgttgactc agtttatcct tgacaaggat gtgacctatc aagatgggaa
     5701 aatcaatcag ttgagactat ggagtgaagt tgattttgat ttggaagata ccatcatttc
     5761 tcctaaatac aatgagcttg aaagaagtag caaactcacc aagcgccaat tctttgagaa
     5821 tcagatgctg gattatacca tcattgcgca tgagagtttt gaaatcatcc gtcattctgt
     5881 ctaccagaca gatgatcgtg aagtggaaaa tgctttggct tttgaagtga aaaatgacga
     5941 aacagacaag ctgattctgt tattaagcga ggatattcgt gtaggtgaaa aattgtgcct
     6001 cgttgacgga acaaaaatgc gtggaaaatg tctagtatat gataaaataa atgagagaat
     6061 gattcgcttg cagtgctaga aataggcatt ttgaatagtg aatatgttat aataagtatt
     6121 agtaggaggt gttttagatt ggagaagaaa ctgaccataa aagacattgc ggaaatggct
     6181 cagacctcga aaacaaccgt gtcattttac ctaaacggga aatatgaaaa aatgtcccaa
     6241 gagacacgtg aaaagattga aaaagttatt catgaaacaa attacaaacc gagcattgtt
     6301 gcgcgtagct taaactccaa acgaacaaaa ttaatcggtg ttttgatcgg tgatattacc
     6361 aacagtttct caaaccaaat tgttaaggga attgaggata tcgccagcca gaatggctac
     6421 caggtaatga taggaaatag taattacagc caagagagtg aggaccggta tattgaaagc
     6481 atgcttctct tgggagtaga cggctttatt attcagccga cctctaattt ccgaaaatat
     6541 tctcgtatca tcgatgagaa aaagaagaaa atggtctttt ttgatagtca gctctatgaa
     6601 caccggacta gctgggttaa aaccaataac tatgatgccg tttatgacat gacccagtcc
     6661 tgtatcgaaa aaggttatga acattttctc ttgattacag cggatacgag tcgtttgagt
     6721 actcggattg agcgggcaag tggttttgtg gatgctttaa cagatgctaa tatgcgtcac
     6781 gccagtctaa ccattgaaga taagcatacg aatttggaac aaattaaaga atttttacaa
     6841 aaagaaatcg atcccgatga aaaaactctg gtatttatcc ctaactgttg ggccctacct
     6901 ctagtcttta ccgttatcaa agagttgaat tataacttgc cgcaagttgg gttgattggt
     6961 tttgacaata cggagtggac ttgcttttct tctccaagtg tttcgacgct ggttcagccc
     7021 tcctttgagg aaggacaaca ggctacaaag attttgattg accagattga aggtcgcaat
     7081 caagaagaaa ggcaacaagt cttggattgt agtgtgaatt ggaaagagtc gactttctaa
     7141 aatgaaggaa aatgacttgc aatctctgtt aagaaataaa ataatcccac ctagaacaag
     7201 ctaggtggga ttatttgcct ataaaatgag aaattatggg agcaagctcc taaatcaact
     7261 gtttttgatc tacttcttta actacttgat aaaagttata gaagtaggcc aaacttgaaa
     7321 tgatggttac gactaggaat attgaaaatt tccattggac agggttggtt aaaagttgtg
     7381 gaaaggatat gaggagaaag aagagggctg cgttgaggac aggtatccgt tttgattgta
     7441 ttttctcaag tcctttattg agcgcaggaa gaaagaggag taggagtagt aaaactgtat
     7501 gagaaacagc tcctgaaata agggcaaaga aaaggaaaat actgataaaa acatgaatga
     7561 tcagtagtct agctagtgat ttcataaggt acctcctaat cctggtcttt tttagctctt
     7621 gcaatacgaa gtgagtcgac aatatgtatc atcactccga aaaagaaagc tcccagtata
     7681 gttttaaaaa tatgttttgt atttagaaga gaagtgataa aatttggatt ttcacttgtt
     7741 agggtatcaa tgagtggaat tataaaaaat atcactattc cataaatcga acctgctttc
     7801 agaccaggat aacgtaactg tttcttttct tttttcatga gtttcctcct aatcattatc
     7861 ctgatctttc ttggcttttg caatgcgacg ggagatgata atttgtataa tcactccgaa
     7921 gaagaaagac tggagaatac ttgaaaaaat atttttaaaa gcgagaagtg actgaagata
     7981 gtcctgactc tcacctagca gtatatggag aagagggctt gaaaaaaaac tcattaatcc
     8041 atagagtaga cctgctttaa gacctgggta gtgtagttgc ttactttctt tctcactcag
     8101 catatctgga tcaatagctg taatccctgt ttttttcatt tggtaggtga catagccagc
     8161 agcgatgagg gcaatcgcta aaatcagagg aggatagatt agagccactt cttgagggta
     8221 tttataggcc agaaggagtg gaataagatt tccgaaaatc atcagataaa agaggatgat
     8281 aaagacttgg ttaccgatac gatcggcctc gcgtcgtttg tattcgtcaa gtggatcaga
     8341 aataccgtat gtgcgcttga tcagtttttc agtgaaggtt tcttttttca taagtttgct
     8401 ccttttttaa aaatcatcct cccaaaagag actgttgagg tcagtttgga ggctgcgggc
     8461 gagattgaga cagagttcca gagttggatt gtacttgtcg ttctcaatca tattgatggt
     8521 ttgtctcgag acaccgatat ccttggctag ctcgagctgg gaaatgccca gttccttgcg
     8581 aaattctttc acacgattca tctggtctcc tttctgaagt gtgtcgtata tatttgacta
     8641 tattatattc ttctatagaa cgaatgtcaa gcatatttga catatttctt aaagaaatct
     8701 tacttgtttt tggcctattt gtctgactag tgcaagctgg tcggatttgt ggtaaaatag
     8761 ataagatatg acaaaagaat ttcatcatgt aacggtctta ctccacgaaa cggttgatat
     8821 gctcgatgta aagcctgacg gtatctacgt tgatgcgact ttgggtggag cgggccatag
     8881 cgaatattta ttaagtaaat taagtgaaaa aggccatctc tatgcctttg accaggacca
     8941 gaatgccatt gacaatgcgc aagaacgctt ggcaccctac attgaaaagg ggatggtgac
     9001 ttttatcaag gataacttcc gtcatttaca ggcacgtttg cgcgaagctg gtgttcagga
     9061 aattgatgga atttgttatg acttgggagt gtctagtcct caattggacc agcgtgagcg
     9121 tggtttttct tataaaaagg acgcgccact ggacatgcgg atgaatcagg aagctagttt
     9181 gacagcctat gaagtggtga atcactatga ctatcatgac ttggttcgta ttttcttcaa
     9241 gtatggtgag gataaattct ctaaacagat tgcccgtaag attgagcaag cgcgtgatct
     9301 gaaacctatc gagactacga ctgaattggc agaaattatc aagtcggcta aaccggccaa
     9361 ggaactcaag aagaagggtc atcctgctaa gcagattttt caggctattc gaattgaagt
     9421 caatgatgaa ctgggagcgg cagatgaatc tatccagcag gctatggata tgctagctct
     9481 tgatgggaga atctcagtga ttacctttca ttccttagaa gaccgcttga ccaagcaatt
     9541 gttcaaggaa gcttcaacgg ttgaagttcc caaaggtttg cctttcatcc cagatgatct
     9601 caatcccaag atggaattgg tatcccgtaa gccaatcttg ccaagtgcag aagagttaga
     9661 agccaataac cgctcgcact cagccaagtt gcgcgtggcc agaaaaattc acaagtaaga
     9721 ggaaaaaaga tggcagaaag aatggaaaaa acaggtcaaa tactacagat gcaacttaaa
     9781 cggttttcgc gtgtggaaaa agctttttac ttttccattg ctgtaaccac tcttattgta
     9841 gccattagta ttatttttat gcagacccga ctcctacaag tacaaaatga tctgacaaaa
     9901 atcaatgcgc agatagagga gaagaagaca gagttggatg ataccaaaca agaggtaaat
     9961 gaattgttga gggcagaacg cttgaaagaa atcgcaaatt ctaaggactt aaaattgaat
    10021 aatgagaata ttcgatcagc ggagtaagat atgaagtgga caaaaagaat aacccgattt
    10081 gcgattagaa accgtaaatc tccagcagaa aaccgtaaaa tagtggggaa gtacatcagc
    10141 ttgttagctg tcgtactttt cgctgtcttt ttggttaatt ttgctgttat tatcgggagt
    10201 ggtagtaaat ttggaacgga tctagtcaaa gaggctaaga aggttcacca aataacccgt
    10261 acagtccctg ccaaacgtgg gactatttat gaccgaaatg gagtcccaat tgctgaggat
    10321 gcaacctcct ataatgtcta tgcggttatt gatgagaact ataagtcagc aacgggtaag
    10381 attctttacg tagaaaaaac acaatttaac aaggttgcag aggtctttca taagtatctg
    10441 gacatggaag aatcttatgt aagagagcaa ctctcgcaac ctaatctcaa gcaagtttcc
    10501 tttggagcaa agggcaatgg gattacctat gccaatatga tgtctatcaa aaaagagttg
    10561 gaaactgcag aggtcaaggg gattgatttt acaaccagtc ccaatcgtag ttacccaaac
    10621 ggacaattcg cttctagttt tattggttta gctcaactcc atgaaaatga agatggcagc
    10681 aagagcttgc tgggaacctc tggaatggag agttccttga acagtattct tgcagggaca
    10741 gacggcatta ttacctatga aaaggatcgt ctgggaaata ttgtccccgg aacggaacaa
    10801 gtttcccaac aaactgtaga tggcaaggat gtttatacga ctatttccag cacccttcag
    10861 tccttcatgg agacccagat ggatgccttt ctagaaaaag taaaaggtaa gtatatgacc
    10921 gcgaccttgg tcagtgcaaa gaccggtgaa atcctcgcta ccacccaacg acctaccttt
    10981 aatgcagata ctaaagaagg aatcactgag gactttgttt ggcgtgatat tctttatcaa
    11041 agtaactatg aaccaggatc agccatgaag gttatgacgt tagcttcttc tattgataat
    11101 aataccttcc caagtggaga atacttcaat agcagtgaat tcaaaatagc ggatgcgacg
    11161 actcgagatt gggatgttaa tgaaggtttg actactggtg ggatgatgac tttcttacaa
    11221 ggtttcgctc actccagtaa tgttggaatg agtctacttg aacaaaaaat gggagatgct
    11281 acttggttgg attatctaaa acgctttaaa tttggggttc caactcgctt tggcttgaca
    11341 gatgaatacg ctggtcaact tccagctgat aatattgtta gtattgctca aagctcattt
    11401 gggcaaggaa tttcagtgac acaaacacaa atgcttcgtg cctttacagc tattgctaat
    11461 gatggagtta tgctggagcc aaaatttata agtgctattt atgatactaa caatcagtct
    11521 gtacgtaagt cacaaaaaga aatagtagga aatcctgttt ccaaagaggc agcaagcaca
    11581 actcgaaatc acatgatctt agttgggacg gaccctctat atggaactat gtataatcac
    11641 tacacaggaa agccaattat aacagttcct ggacaaaatg tagcagttaa atccggtacg
    11701 gctcaaatcg ctgatgagaa aaatggagga tacttggttg gttctaccaa ttatattttc
    11761 tcagctgtga ctatgaatcc tgctgaaaat cctgatttta tcctctatgt gacggttcaa
    11821 cagcctgagc attattcagg tattcagttg ggggaatttg ccaatcctat cttggaaaga
    11881 gcagtggcca tgaaagattc ccttaacctc caatctaccg ctaaaacgtt agatcaggta
    11941 accaatcaaa gcgcttatgc catgcctagc atcaaggaca tttcacccgg tgatttggcg
    12001 gaagccttac gtcgcaatat tgtgcaacca atcgttgtgg gaacaggaac aaagattaaa
    12061 gaatcatctg tagaagaagg gactaatctt gcacctaacc agcaagttct cctcttatct
    12121 gataaagcag aggaagttcc agatatgtat ggttggacaa aagcaaccgc agaagctttt
    12181 tctaagtggt taaatataga acttgtattt gaaggttcag gctctactgt gcagaagcag
    12241 gatgttcgtg ctaatacagc tatcaaggac attaaaaaaa ttacattaac tttaggagac
    12301 taatatgttt atttccatca gtgctggaat tgtgacattt ttactaactt tggtaggaat
    12361 tccagccttt atccaatttt atagaaaggc gcaaattaca ggccagcaga tgcatgagga
    12421 tgtcaaacag catcaggcaa aagctggcac gccaactatg gggggacttg ttttccttat
    12481 tgctgcagtt gtagtgagtt tccttcttgc tcttttttca aaacaattga ccaataatgt
    12541 gggaatgatt ttgttcatct tggtccttta tggacttgtc ggatttttag atgactttct
    12601 caaggtcttt cgtaaaatca atgaggggct gaatcctaag cagaaattgg ctcttcagct
    12661 tttaggtggg gtcgtcttct accttttcta tgagcgcggt ggagatatgc tttctgtctt
    12721 tggttaccaa gtgcatctag ggattttcta tattgtcttc gctcttttct ggctagtcgg
    12781 tttttcaaac gcagtaaact tgacagacgg cattgacggt ttagctagta tttccgttgt
    12841 gattagtttg tctgcctatg gagttattgc ctatgtgcaa ggtcagatgg atatcctact
    12901 agtgattctg gccatgattg gtggtttgct tgggttcttt gtctttaacc ataagcctgc
    12961 taaggtcttt atgggagatg tgggaagttt agctcttggt ggaatgctgg cagctatttc
    13021 aatggctctc caccaagaat ggactctctt gattatcgga attatttatg tctttgaaac
    13081 aacttcggtc atgatgcaag tcagctattt caaactgaca ggtggtaaac gtattttccg
    13141 tatgacgcct gtgcatcacc attttgagct tggaggattg tctggtaaag gaaatccttg
    13201 gagcgagtgg aaggttgatt tcttcttttg gggagtgggg cttctagcaa gtctcctgac
    13261 cctagcaatt ttgtatttga tgtaagaatg gcaccctgat gtttcagggt gtttttgctt
    13321 ttttaaaaat attggtcaat taaagtcaaa atccttgacc ttttctgact aatgtagtat
    13381 attatgaacg taaggtaaat gaaagcctta ctagaacgct tatactcaat gaaaatcaac
    13441 gagcaaacta ggaagtgctc aaaacactgt tttgaggtta cagatagaac tgacgtggtt
    13501 tgaagagatt ttcgaagagt ataaaaaaca ttggtcaatc aaagtcaaaa tccttgacct
    13561 tttctgacca atgtagtata ttatgaacgt aaggtaaatg aaagccttac tcgaacactt
    13621 atactcaatg aaaatcaacg agcaaactag gaagctagac gcaggttgct caaaacactg
    13681 ttttgaggtt gcagatagag ctgacgtggt ttgaagagat tttcgaagag tattatttaa
    13741 agtaaaatag aaagaggtgg ggtctatgtt taatctagaa atcttcagaa gtaaagatag
    13801 tctactcctg cttgaaaaag aaaaaccaga aatagtatgt agagtagcga tttagctaat
    13861 ctaaattttt taaaacaaag gtcaaagata gtcaatatca gtaataataa ataacaaaaa
    13921 gaggtacaga gtatgaacaa caactttaat aattttaaca acatggatga tttatttaac
    13981 caattgatgg gtggtatgcg aggatatagt tctgaaaatc gtcgctactt gattaatgga
    14041 cgtgaagtca cacctgagga atttgctcac tatcgtgcaa cgggtcaatt gccaggaaat
    14101 gtagaagttg atggccgaat gccacaacag gcttcaagta tgaaacaaga cggtgtcctt
    14161 gctaaactag gtcgaaactt gacagcagaa gctcgcgagg gcaagttgga tcctgttatc
    14221 ggacgaaaca aggaaattca agaaacgtct gaaattcttt cacgccgtac caagaacaat
    14281 cctgttttgg tcggagatgc aggtgttggt aagacagcag ttgtcgaagg tctagcacaa
    14341 gcgattgtga atggtgatgt tccagctgct attaagaaca aggaaattat ttccattgat
    14401 atttcaggtc ttgaggctgg tactcaatac cgcggtagtt ttgaagaaaa cgttcaaaac
    14461 ttagtcaatg aagtgaaaga agcgggaaat atcattctct tctttgatga aattcaccaa
    14521 atcctcggtg ctggatctac tggaggtgac agtggttcta aggggcttgc ggatattctc
    14581 aaaccagctc tctctcgtgg agaattgaca gtgattgggg caacaactca agacgaatac
    14641 cgtaatacca tcttgaagaa tgctgctctt gctcgtcgtt tcaacgaagt caaggtcaat
    14701 gctccttcag cagaggatac atataaaatc cttcaaggaa ttcgtgacct ctatcaacaa
    14761 caccacaatg tcattttgcc agacgaggtc ttgaaagcag cagtggatta ttctgttcaa
    14821 tacattcctc aacgtagctt gccagataag gctatcgacc ttgtggacgt aacggcagcc
    14881 cacttggcag ctcagcatcc tgtaacagat gtgcatgctg ttgaacgtga aatagaggca
    14941 gaaaaagaca agcaagaaaa agctgttgag gcagaagatt ttgaggcggc tctaaactat
    15001 aaaacacgca tcgcagaatt ggaaaagaaa atcgaaaacc acacagaaga tatgaaagtg
    15061 actgcaagtg tcaacgatgt ggctgagtct gtagaacgaa tgacgggtat tccagtgtca
    15121 caaatgggag catcagatat cgaacgtttg aaagatatgg ctcatcgctt gcaagataag
    15181 gtaatcggcc aagataaggc agttgaagct gtagcccgtg ccatccgtcg taaccgtgct
    15241 ggttttgatg aaggtaatcg cccaatcggt agcttcctct ttgtaggacc cactggggtt
    15301 ggtaagacgg aacttgctaa acaattggca ctggatatgt ttggaaccaa ggatgcgatc
    15361 atccgtttgg atatgtctga atacagtgat cgcacagctg tttctaagct aattggtaca
    15421 acagcaggct atgtgggtta tgatgacaat agcaatacct taacagaacg tgttcgtcgc
    15481 aatccatact ctatcattct cttggatgaa attgaaaagg ctgaccctca agttattacc
    15541 cttctcctcc aagttctaga tgatggtcgt ttgacagatg gtcaaggaaa tacagtaaac
    15601 ttcaagaaca ctgtcattat tgcgacctca aatgctggat ttggctatga agccaacttg
    15661 acagaagatg cggataaacc agaattgatg gaccgtttga aacccttctt ccgtccagaa
    15721 ttcctcaacc gctttaatgc agtcatcgag ttctcacact tgactaagga agatctttct
    15781 aagattgtag atttgatgtt ggctgaagtt aaccaaacct tggctaagaa agacattgac
    15841 ttggtagtta gtcaagcggc taaagattat atcacagaag aaggttacga tgaagtcatg
    15901 ggggttcgtc ctctccgtcg cgtggttgaa caagaaattc gtgataaggt gacagacttc
    15961 cacttggatc atttagatgc taaacatctg gaagcagata tggaagatgg cgttttggtt
    16021 attcgtgaga aagtctaaga cagaattttg aggataaaaa agaaggagcc agctgaaaaa
    16081 aactggttcc ttttgaggta tgacgggcat gtcgtatagt agaagtgtat tattctagtt
    16141 tcaatccact atagtagctc agaagtcggt acttaaacgt gctatatcaa aaccagtcct
    16201 tgaaaaacgt ggattggttt cgtgtttgga ttattacctt gaacgacatg cgttaaaagt
    16261 tagttgaacc gccgtatgcc gaacggcacg tacggtggtg tgagaggggc tagagattat
    16321 cccctactcg attttaaatc acatgacgtt caaaggcatc atctgaaatc ccttgttcca
    16381 agatgagttt tgcccattct ttagcagaga agaggctgtg gtccttgtag tttccgcaag
    16441 attcgatggt tgtccctggg acatcttccc aagtagtagt ttcagcgatt tccttgagcg
    16501 aatccttgat aacagctgcg attttagcac tggtgtgacg tccccacata atcatgtgga
    16561 agcctgtgcg gcaaccaaat ggtgaacagt caatcatgcc gtcaatgcgg gtacggatga
    16621 gtttggctaa gaggtgctcg atagtgtgaa ggccggcagt agggatagag tcttcgtttg
    16681 gttgcaccaa gcgaatatca taattggaga tgatgtctcc ttttggtcct gtttcttccc
    16741 caatcaagcg aacatagggt gctttgacaa tggtgtggtc aagttcaaaa ctttcgacaa
    16801 taacttcttt tgacatggta aatcctttca gttttcttct ctcattatat cataaagctt
    16861 gctcctgaga cagagagaaa acctctccga ggctggagag gttgaaatct ttacttacga
    16921 tataagcggt cgtattggta gtatgggtca aaggttacgt tgatacccag tttacgaagg
    16981 acattcttgt cttcatcagt caagatgatg gttgagtggg cttcgcttcc tttgaggttg
    17041 ccgagttctt ccatagcgcg ggcagcatca ggattttctg tagctgtgat agcaagtgca
    17101 atcaggattt catttgaatg aaggcgtgga ttgcggctac cgagatgatc gattttaagt
    17161 ccttggattg gcttaacaac ttcaggctcg attagtttta cttctttagc gatgtcagct
    17221 gattttttga tggcgttgat caaggcagcg gctgtagggc caaagagttc tgagttttta
    17281 ccagtgacaa tgtcaccatt tggtaattca agagctaggg ctggtccgcc agtttcttct
    17341 gctttttggc gcgcaacgac agcaacctta cggtctgcag gtgtgatacc gaggtcgttc
    17401 atgagcaact caattttctt gacggcagct tcgccaactt tttcagcttt gaagtcaaga
    17461 actgtttgat agtaacgacg gatgatttct tgtttagaag cttcgacagc agcctcgtca
    17521 tctgtaatag cgaaaccaac catgttgaca cccatatctg tcggtgaagc gtatggcgat
    17581 tttccgagaa tacgttccaa catgcgcttg agcactggga agatttcgat atcacggttg
    17641 tagttgacag tggtttctcc ataggtttga agatggaagg ggtcaatcat gttgacatca
    17701 tcaaggtcag ctgtggcagc ttcataagcc aagttaactg gatgatgaag gggaagattc
    17761 caaacaggga aggtttcaaa tttagcgtag ccagacttga tgccattgat ttggtcgtgg
    17821 tacatattgg acatacacgt tgccaatttt ccagaaccgg gtccaggagc ggttacgaca
    17881 atcaagttgc gactggtttt gatgtagtcg tttttgccca tgccttctgg ggaaatgatg
    17941 tgatccatat ccgtcggata tcctttgatt ggataatgaa gataagaatc aattccgttt
    18001 ttctcaagtt ggttgcggaa ggcatctgca gcgggttggc cagcgtattg tgtaatgaca
    18061 acggaaccaa caaaaatccc taattcattg aatttgtcaa tcaaacgaag aacttcttgg
    18121 tcataagaaa tgcctaagtc gccacgtgct ttggaatgtt caatgttgct agcattaatg
    18181 gcaatcacaa cctcaacctg ctctttcaat tcttgcaaga gcttgatttt gttgtcaggt
    18241 tcataaccag gaaggacacg agcagcgtgg aaatcttcta acattttacc gccaaactct
    18301 aagtagagct tgccgtcaaa ttggttaatg cgctctaaga tgtggtcgcg ttgtagattt
    18361 aaatattgtt cagaactaaa agcttgtttt ttcatttttt tacctctgga ctctattata
    18421 ataaaaaatt ggaagttagg aaactacgga gctaaaaaag aaattaaaaa gattaagcaa
    18481 acgcttgcac aaaattttaa aaagtgctat catagactat agattatgaa aataatgagg
    18541 taaacagatg caagaaaaat ggtggcataa tgccgtagtc tatcaagtct atccaaagag
    18601 ttttatggat agtaatggag atggaattgg cgatttgcca ggaattacca gtaagttgga
    18661 ctatctagcc aagctaggaa tcacagcaat ttggctttct cccgtttatg acagccctat
    18721 ggatgataat ggctacgata ttgctgatta tcaagcgatt gcaacgattt ttggaaccat
    18781 ggaggatatg gatcaactga ttgcagaagc taagaagcgt gatatccgta tcatcatgga
    18841 cttggtggtc aatcatacct cggatgagca tgcctggttt gtagaggcct gtgaaaatcc
    18901 taatagccct gagcgagact actatatctg gcgcgatgaa cccaatgacc tagattctat
    18961 ctttagtggg tctgcttggg aatacgatga aaagtcaggt caatactatc tccacttttt
    19021 cagcaagaaa cagccggatc tcaactggga aaatgaaaaa cttcgccaga aaatttatga
    19081 gatgatgaac ttctggattg ataaaggtat tggtggtttc cgtatggatg ttattgacat
    19141 gattggcaaa attcctgacg agaaggtagt caataatggt cctatgctcc atccctatct
    19201 caaggaaatg aatcaggcga cctttggaga taaggatctc ttgacagtag gggagacttg
    19261 gggagcaacg ccagagattg ccaagctcta ctctgatcca aaggggcaag aattgtctat
    19321 ggtcttccag tttgaacata tcggtcttca gtatcaggaa ggtcaaccta aatggcacta
    19381 tcaaaaagag ctgaatatcg ctaagttaaa agaaatcttc aacaaatggc agacagagtt
    19441 aggagttgag gacggctgga attccctctt ctggaacaac catgacctcc ctcgtattgt
    19501 ctcaatctgg ggaaatgacc aagaataccg cgaaaaatct gccaaagcct ttgcaatctt
    19561 acttcatctc atgagaggaa ctccttatat ctaccaaggt gaggagattg ggatgaccaa
    19621 ctatccgttt gaaacactgg atcaagtaga agatattgaa tctctcaact atgcgcgtga
    19681 ggctcttgaa aaaggtgttc cgattgaaga aatcatggac agtatccgtg ttattggacg
    19741 tgacaatgcc cgtaccccta tgcaatggga cgagagcaaa aacgctggtt tctcaacagg
    19801 tcaaccttgg ttggcggtta atccaaatta cgagatgatc aatgtccaag aagcgctggc
    19861 aaatccagat tctattttct atacctatca gaaactggtc caaattcgca aggagaatag
    19921 ctggctagtt cgagctgact ttgaattgct tgatacggct gataaggtct ttgcttatat
    19981 acgtaaggat ggcgaccgtc gcttcctagt tgtggctaac ttgtccaatg aagagcaaga
    20041 cttgacagta gaaggaaaag tcaaatctgt cttgattgaa aacactgcgg ctaaagaagt
    20101 acttgaaaaa caggtcttgg ctccatggga tgctttctgt gtggaattac tataaatatt
    20161 ttttgcagaa aaatttaaaa ttgaaatcat ataaaaacaa gggaggactg tataaaagac
    20221 agaaatcctt tgttttttat aaccaaggtt tataaacttt cattctcgaa attcaattaa
    20281 ctttacaaat tcccactatt taaggagaaa gaagatgaac ataaagaagc gagtccttag
    20341 tgcaggcctg acttttgcat ctgctttgct tttagctgct tgcggccaat caggttcaga
    20401 tacaaaaact tactcatcaa cctttggtgg aaatccaact acatttaact atctattaga
    20461 ctattacgct gataacatag tcaattgaaa caagaaca
//
LOCUS       DBERMM010000035        20348 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.035, whole genome shotgun sequence.
ACCESSION   DBERMM010000035 DBERMM010000000
VERSION     DBERMM010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 20348)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20348)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20348
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.035"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            229..1038
                     /locus_tag="ACL8AS_001557"
     CDS             229..1038
                     /locus_tag="ACL8AS_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000926538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HGS1229391.1"
                     /translation="MLLQKELIPMIEANLPNMAYAEKDIAKFFLKQQPLNDYSSKALC
                     EYLNVSKATLTRFAKKCGFKGFRQFIFKYQEMIHEKEKLALYTEATEKVLSDYEEMLR
                     KTYTVLDEVQLERIAEMIETAERVYLYGKGSSVLALQEMKMRFMRLGVIGEVLSDEDM
                     ILWSSLLLNENCLVIGASISGQTDIVLEGLQKAADKGAKTVLMTTRKFDEEDCFFDEL
                     LLLASTDHLSYGNRISPQFPILLITDCLFSNYLESPERQYYYNQTIIHKEE"
     gene            1043..1744
                     /locus_tag="ACL8AS_001558"
     CDS             1043..1744
                     /locus_tag="ACL8AS_001558"
                     /EC_number="5.1.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009385 - N-acylmannosamine-6-phosphate
                     2-epimerase activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006051 - N-acetylmannosamine metabolic
                     process [Evidence IEA];
                     GO_process: GO:0019262 - N-acetylneuraminate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HGS1229392.1"
                     /translation="MSQIWTKEKFISQVQGGVIVSCQALPGEALYNEEFSLMPFMAKA
                     ALEAGAVGIRANSVRDIKAIQKVVDLPIIGIIKRDYPPQEPYITATMKEVDELVECGT
                     TVIAFDATLRPRYDGLVVSEFIKKIKEKYPNQLLMADVSNLDEGLYAFKSGVDFVGTT
                     LSGYTSTSVQSDEPDFELMKKLADFNIPVIAEGKIHYPEQLKKAYSLGVTSVVIGGAI
                     TRPKEIAQRFINVIK"
     gene            1769..2686
                     /locus_tag="ACL8AS_001559"
     CDS             1769..2686
                     /locus_tag="ACL8AS_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000654132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HGS1229393.1"
                     /translation="MKDLTKYKGVIPAFYACYDENGEISQDRVKSLVQYFIDKGVKGI
                     YVNGSSGECIYQSVEDRKQIIEAVMEVAKGKLTVINHIACNNTKDSIELAKHSESVGV
                     DAIAAIPPIYFKLPEYSIAAYWNAMSEAASNTDFIIYNIPQLAGVALTGSLYATMRQN
                     PRVIGVKNSSMPVQDIQMFVAAGGEDYIVFNGPDEQYLGGRLMGAEAGIGGTYGVMPD
                     LFLKLESLIQERDLDTAKKLQYAINEVIYKMISGKANMYAVAKEVLRLNEKLDLGSVR
                     QPLEALAEGDLEVAKQAAELIQQARKEFL"
     gene            2714..4255
                     /locus_tag="ACL8AS_001560"
     CDS             2714..4255
                     /locus_tag="ACL8AS_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000537364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HGS1229394.1"
                     /translation="MGTTGFTIIDLIILIVYLLAVLVAGIYFSKKEMKGKEFFKGDGS
                     VPWYVTSVSIFATMLSPISFLGLAGSSYAGSWILWFAQLGMVVAIPLTIRFILPIFAR
                     IDIDTAYDYLDKRFNSKALRIISALLFIIYQLGRMSIIMYLPSAGLSVLTGIDINILI
                     ILMGVVAIVYSYTGGLKSVLWTDFIQGVILISGVVLALFVLIANIKGGFGAVAETLAN
                     GKFLAANEKLFDPNLLSNSIFLIVMGSGFTILSSYASSQDLVQRFTTTQNIKKLNKML
                     FTNGVLSLATATVFYLIGTGLYVFYQVQNADSAASNIPQDQIFMYFIAYQLPVGITGL
                     ILAAIYAASQSTISTGLNSVATSWTLDIQDVISKNMSDNRRTKIAQFVSLAVGLFSIG
                     VSIVMAHSDIKSAYEWFNSFMGLVLGLLGGVFILGFVSKKANKQGAYAALIVSTIVMV
                     FIKYFLPPTAVSYWAYSLISISVSVVSGYIVSVLTGNKVSAPKYTTIHDITEIKADSS
                     WEVRH"
     gene            4274..4732
                     /locus_tag="ACL8AS_001561"
     CDS             4274..4732
                     /locus_tag="ACL8AS_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HGS1229395.1"
                     /translation="MIISEQSDFKRYASVNKYFSKVCDFLENTNLTDLVDGKIDIDGE
                     NVFANCMTYLADGVPGDIFETHKKYLDIHIVVENTEKMAVTSPVRAQSRVPFSEEKDI
                     AFYDSKDYQIVELLPGNMLVTFEEDLHQPKIHCNDETVKKLVIKVLNEEK"
     gene            4734..6956
                     /locus_tag="ACL8AS_001562"
     CDS             4734..6956
                     /locus_tag="ACL8AS_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004308 - exo-alpha-sialidase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sialidase domain-containing protein"
                     /protein_id="HGS1229396.1"
                     /translation="MKKNIKQYVTLGTVVVLSAFVANSVAAQETETSEVSTPKLVQPV
                     APTTPISEVQPTSDNSSEVTVQPRTVETTVKDPSSTAEETPVLEKNNVTLTGGGENVT
                     KELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEA
                     RDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNF
                     LNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHL
                     IYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTW
                     TKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPA
                     GVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDK
                     NFGIKQNGNYLTVEQYSVSFENNKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISS
                     NDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDN
                     GASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYL
                     KFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRY
                     HHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKN
                     "
     gene            6996..8105
                     /locus_tag="ACL8AS_001563"
     CDS             6996..8105
                     /locus_tag="ACL8AS_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HGS1229397.1"
                     /translation="MVNYGIVGAGYFGADLARSMNKIEDAKVVAVFDPNHGEEVAQEL
                     GSDVCASLDELVAREDIDCVIVASPSYLHREPVVKAAQHGKHVFCEKPIALSYEDCKA
                     MVDACKENNVIFMAGHIMNFFNGVHHAKELITQGKIGKVLYCHAARTGWEEQQPTVSW
                     KKLRSQSGGHLYHHIHELDCIQFIMGGLPEKATMVGGNVYHKGENFGDEDDMLIVNLE
                     YSDDRYAVLEYGNAFRWGEHYVLIQGTEGAIKLDLFNTGGTLRVKGEGESHFLVHETQ
                     EEDDDRTAIYTGRGMDGAIAYGKPGVRCPLWLQTCIDKEMEYLHDIIKGGEITEEFEK
                     LLNGVAALESIATADACTLSVKEDRKVSLSEITNA"
     gene            8262..9152
                     /locus_tag="ACL8AS_001564"
     CDS             8262..9152
                     /locus_tag="ACL8AS_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HGS1229398.1"
                     /translation="MKIIGIDIGGTTIKADLYDEFGTSLNHFKEIETIIDYDLGTNQI
                     LNQVCDLIGEYTLNHSIDGVGISTAGVVNANTGEIIYAGYTIPGYIGVNFTAEIEKRF
                     GLYTFVENDVNCAALGELWKGQAKDKKNVVMVTIGTGIGGSIIVNGQIVNGFNYTAGE
                     VGYIPVGNSDWQSKASTTALIHLYQKKSLKTNQTGRTFFTDLRSGDKVAEETFEIFVE
                     NLTKGLLTISYLLNPEILILGGGILDSKDILLPEIQSSLAKNAMDNRFLPKNLVAATL
                     GNEAGRIGAVKNFLDRISNK"
     gene            9177..9500
                     /locus_tag="ACL8AS_001565"
     CDS             9177..9500
                     /locus_tag="ACL8AS_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229399.1"
                     /translation="MTNSVFSTMQDIENVATDIIKSYDNEIYTYKAVSQEELEKLEKS
                     YDEKSHEELVSIESNLEMKQQNLIDEVNKTIKENDANIQYISSSRRGEFVEKIIGRVV
                     EKYGH"
     gene            9490..11481
                     /locus_tag="ACL8AS_001566"
     CDS             9490..11481
                     /locus_tag="ACL8AS_001566"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit I"
                     /protein_id="HGS1229400.1"
                     /translation="MAISQMKRISLLFSKSSLDDVLKTIQELESVQFRDLKVQDNWSE
                     ALEKDEVVFPTIQIFHTSNSNHGVIEGNDALTYLMNQQQHLEATVEKLQEYLPKENTF
                     KLLQQPPITTSYEELEKFGKANVAEGVLKKVNHQINRVHELERHIQSNNEEIERLIKW
                     EKLEIVPANLEQFSFCKGKVGTIPRTEDNRLYNSLLENNIEVQEIFSNDREYGVVVFY
                     QSSYSIDFDEYLFEPFDYSRKELPKQRVVDLDQENMQLITEKENIIASLQDSKKYLID
                     LQWQIDYILSIYARQISKNNFLCTPHLVALEGWIEETRILYFIKVMDEHFGHSIYIYE
                     SETLTDNQDEIPIKLTNHSLIEPFELLTEMYALPKYYEKDPTPVLAPFYFTFFGMMVA
                     DLGYGLLLFLGTMLALKIFHLPSATKRFLKFFNILGVAVAIWGGIYGSFFGYELPFHL
                     ISTTSDVMTILVVSVVFGFITVFAGLLASGLQKVRMKKYAEAYNSGFAWCVILLGLLF
                     IAVGMLMPDMRPLFVLGKWVSIFNAVGILIVSIIQTKSLSGIGAGLFNLYNISSYIGD
                     LVSFTRLMALGLSGASIASAFNLIVGLFPGILAKLTIGLVLFILLHAINIFLSLLSGY
                     VHGARLIFVEFFGKFYEGGGKPFQPLKASEKYIKVITKN"
     gene            11497..11973
                     /locus_tag="ACL8AS_001567"
     CDS             11497..11973
                     /locus_tag="ACL8AS_001567"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit K"
                     /protein_id="HGS1229401.1"
                     /translation="MEHLATYFSTYGGAFFAALGIVLAVGLSGMGSAYGVGKAGQSAA
                     ALLKEQPEKFASALILQLLPGTQGLYGFVIGILIWLQLTPELPLEKGVAYFFVALPIA
                     IVGYFSAKHQGNVAVAGMQILAKRPKEFMKGAILAAMVETYAILAFVVSFILTLRV"
     gene            12007..12588
                     /locus_tag="ACL8AS_001568"
     CDS             12007..12588
                     /locus_tag="ACL8AS_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000067169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229402.1"
                     /translation="MSNLENLRESVIEQAHEKGRMKLLDSKKKIDDEFEMQKSLIIKK
                     KEAEHERKLKELQQKYQIIFQQLKNKERQSTLVSKQKILKELFQSALLEMESWSADKE
                     MEFIYRILERYSQQEVIVTFGERTLAKFNLEQLEKLKFSFPNYLFSEQPISNESGLLI
                     SIGKIDDNYLYKTLIGSISKEESSSIANQIFIN"
     gene            12653..13660
                     /locus_tag="ACL8AS_001569"
     CDS             12653..13660
                     /locus_tag="ACL8AS_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000380539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046961 - proton-transporting ATPase
                     activity, rotational mechanism [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATPase subunit"
                     /protein_id="HGS1229403.1"
                     /translation="MDTNLFSKINTTISVKENDFITEEKFQKIIQSKDTETLAFILES
                     TPYHLSIDILEDPSQTEISLMTKLVNDYRWAYAESPSDIIVTLFALRYVYHNIKVLLK
                     SKAAIKKDFSKLLIPIGIFDIESLKHLVSSLHSDTLPDFMVREVESIWNEYETFNNIR
                     VLDVGADLAYFKHLKLLSNELDEVLSQVIVEMIDFYNIITVKRGLSQNKSHGDILQLL
                     SDEGSISAKEFIYIVENQEIFVWFNKINPSLDSIFSTYELKMQDATISSSELEFLCDL
                     LLYKTLDQGRYNVEGPLVLARYLLGCEFEVKNLRMIISALQNTIPFESIKERIRPHYG
                     S"
     gene            13650..13970
                     /locus_tag="ACL8AS_001570"
     CDS             13650..13970
                     /locus_tag="ACL8AS_001570"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit F"
                     /protein_id="HGS1229404.1"
                     /translation="MEANKYKIGIIGSRDIILPFSMIGFDIFPAYQEQEAINTLRKLA
                     QSDYGVIYITEDIASMILDTIRHYDSQVVPAIILLPTHKQGLNLGLKRIEDNVEKAVG
                     HNIL"
     gene            14033..15808
                     /locus_tag="ACL8AS_001571"
     CDS             14033..15808
                     /locus_tag="ACL8AS_001571"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit A"
                     /protein_id="HGS1229405.1"
                     /translation="MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRR
                     DQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDF
                     LVRGVEVPSLDRDIKWHFDSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVV
                     SIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVID
                     AFFPVTKGGAAAVPGPFGAGKTVVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPE
                     LIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRDMGYSVAIMADSTSR
                     WAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQVLGLPEREGTITAIGAVS
                     PPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDGKE
                     KTDWNSKITRAMNYLQRESSLEEIVRLVGIDSLSDNERLTMEIAKQIREDYLQQNAFD
                     SVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIMEGTVAVRDRMARSKYVSED
                     RLDEIKIISNEITHQIHLILETGGL"
     gene            15809..17194
                     /locus_tag="ACL8AS_001572"
     CDS             15809..17194
                     /locus_tag="ACL8AS_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000111247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit B"
                     /protein_id="HGS1229406.1"
                     /translation="MSVIKEYRTASEVVGPLMIVEQVNNVSYNELVEIQLHNGEIRRG
                     QVLEIHEDKAMVQLFEGSSGINLEKSKIRFAGHALELAVSEDMVGRIFNGMGKPIDGG
                     PDLIPEKYLDIDGQAINPVSRDYPDEFIQTGISSIDHLNTLVRGQKLPVFSGSGLPHN
                     ELAAQIARQATVLNSDENFAVVFAAMGITFEEAEFFMEELRKTGAIDRSVLFMNLAND
                     PAIERIATPRIALTAAEYLAFEKDMHVLVIMTDMTNYCEALREVSAARREVPGRRGYP
                     GYLYTNLSTLYERAGRLVGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSHE
                     LYNQGYRPPINVLPSLSRLKDKGSGEGKTRGDHAPTMNQLFAAYAQGKKVEELAVVLG
                     ESALSDVDKLYVRFTKRFEEEYINQGFYKNRNIEDTLNLGWELLSILPRTELKRIKDD
                     LLDKYLPLVEV"
     gene            17217..17828
                     /locus_tag="ACL8AS_001573"
     CDS             17217..17828
                     /locus_tag="ACL8AS_001573"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000251933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit D"
                     /protein_id="HGS1229407.1"
                     /translation="MVRLNVKPTRMELNNLKERLTTAERGHKLLKDKRDELMRRFISL
                     IRENNQLRKEVESYLIDNLKSFAVAKSLKNSQMVEELFSIPSKEIELFVEKENIMSVT
                     VPRMHMNITSQNENSEYSYLSSNSEMDDVFATMNSLIYKLLRLAEVEKTCQLMADEIE
                     KTRRRVNGLEYSIIPNLSETIHYIELKLEEAERANLVRIMKVK"
     gene            18101..18286
                     /locus_tag="ACL8AS_001574"
     CDS             18101..18286
                     /locus_tag="ACL8AS_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136123.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229408.1"
                     /translation="MPQPIVPVEIPQSRRFDSKKRNDILLKIRIGKLEVSFFQSLNLE
                     MVEQLLDKVLLYDNSSI"
     gene            18267..18590
                     /gene="tnpB"
                     /locus_tag="ACL8AS_001575"
     CDS             18267..18590
                     /gene="tnpB"
                     /locus_tag="ACL8AS_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HGS1229409.1"
                     /translation="MTIHLSSLGEVYLVCGKTDMRQGIDSLAYLVKTHFELDPFSGQV
                     FLFCGGRKDRFKVLYWDGQGFWLLYKRFENGRLIWLSTEKDVKALTPEQVDWLMKGFS
                     ITPKI"
     gene            complement(18745..19053)
                     /locus_tag="ACL8AS_001576"
                     /pseudo
     CDS             complement(18745..19053)
                     /locus_tag="ACL8AS_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            19035..19472
                     /locus_tag="ACL8AS_001577"
                     /pseudo
     CDS             19035..19472
                     /locus_tag="ACL8AS_001577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050084071.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
     gene            19579..20237
                     /locus_tag="ACL8AS_001578"
                     /pseudo
     CDS             19579..20237
                     /locus_tag="ACL8AS_001578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050084071.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
BASE COUNT         6794 a         3000 c         4058 g         6496 t
ORIGIN      
        1 taaaatatta ctaaaatatt ttaatatgaa catattatta gtgataaacg ttcttacaat
       61 acatataatt acgataaaaa gaataaaaac tattatattt ttatgtttgt tgttctgtta
      121 tgaaacgaaa gaaattggaa actagtttct aatttatgaa aaatattgaa aaaaaaaaaa
      181 agtgttaaaa taaagaatgt aaacgtttac ttcaactaag gagctcatat gttactgcaa
      241 aaagaactaa ttccaatgat agaagctaac ttaccaaata tggcatatgc tgaaaaagac
      301 attgctaaat tcttcttaaa acagcaacct ctgaatgatt attcatctaa agcattgtgc
      361 gaatacctta atgtatccaa agcaacattg actcgatttg cgaaaaaatg tggttttaaa
      421 ggttttagac aattcatttt caaataccaa gagatgattc atgagaaaga aaagttggca
      481 ttatatacag aggcaacaga aaaagtttta tccgactatg aggaaatgtt gagaaaaact
      541 tacacggttc ttgatgaagt tcaacttgag cgtattgctg agatgataga aactgctgag
      601 cgtgtatatc tctacggtaa aggaagttct gttcttgctt tacaagaaat gaagatgaga
      661 tttatgcgtc tcggagtgat tggtgaagta ttatcagacg aggatatgat tttgtggagt
      721 agcttactac ttaatgaaaa ttgccttgtc attggagcat ccatttcagg tcaaactgat
      781 attgtactag aaggtctaca aaaagctgca gataaaggcg ctaaaacagt tttaatgact
      841 acaagaaaat ttgacgaaga agattgtttc tttgatgaac tattgttatt agcttcgacc
      901 gatcatctct cgtatggcaa tcgcatatca cctcagtttc caatactttt aattacagac
      961 tgcttattct ctaattatct ggaaagtcca gagagacaat attattacaa tcaaactatt
     1021 atccataagg aggaataata aaatgagcca aatttggact aaagaaaaat ttataagcca
     1081 agttcaaggt ggagtcattg tttcttgtca agctttacct ggtgaagccc tttataatga
     1141 agaatttagc ttgatgcctt ttatggctaa agcagcttta gaggcaggag cagtgggcat
     1201 tcgcgcaaat tctgtgcgtg atattaaagc aattcagaaa gtagtagatt taccaataat
     1261 tggaattatc aaaagggatt atccacctca agaaccatat attactgcta cgatgaaaga
     1321 agtagatgaa cttgtagaat gcggaacaac agtcattgca tttgatgcaa ctttaagacc
     1381 aagatatgat ggcttagttg tcagtgaatt tatcaaaaaa ataaaagaaa aatatccgaa
     1441 tcaattgctg atggcggatg taagtaattt agatgaaggt ctctatgcat ttaaatcagg
     1501 cgttgatttt gttggtacaa cattatcagg ttacacaagt acaagtgtac aatcagatga
     1561 gcctgatttt gaactaatga aaaaattggc tgattttaat attccggtaa ttgccgaagg
     1621 aaaaattcat tatccagaac aattaaaaaa agcttatagt ttaggtgtta ccagtgtagt
     1681 cattggtgga gcgattacac gtccaaaaga aattgctcag cgatttatta atgtcatcaa
     1741 ataaaaaaca atataaagga gaaatctgat gaaagattta actaaataca aaggcgttat
     1801 ccctgcattt tatgcttgct atgatgaaaa tggtgaaatt agccaagatc gtgtaaaatc
     1861 tctggtacaa tatttcattg acaaaggtgt aaaaggtatc tatgtaaatg gttcttcagg
     1921 tgaatgtatt taccaaagtg tagaagatcg taaacaaatt attgaagctg ttatggaagt
     1981 tgctaaaggt aaattaacag ttatcaacca tattgcatgt aataacacga aagatagtat
     2041 cgaattggca aaacattcag aaagtgttgg agtcgatgct attgcagcta tcccacctat
     2101 ttatttcaaa ttgccagagt attcaatcgc agcatattgg aatgcaatga gtgaagctgc
     2161 gtcaaataca gattttatta tctataatat tccacaattg gcaggggttg cgttgactgg
     2221 tagtttgtat gcaacaatgc gtcaaaatcc tcgtgtgatt ggagttaaaa attcttctat
     2281 gcctgtacaa gatattcaaa tgtttgtagc tgcaggtgga gaagattaca ttgtattcaa
     2341 tggtccagat gaacaatatc ttggtggtcg cttgatggga gcagaagctg gtattggtgg
     2401 tacttatggc gttatgccag atttgttctt gaaattggaa agtttgattc aagaacgaga
     2461 tttagataca gctaaaaaac ttcaatatgc tatcaatgaa gttatctata agatgatatc
     2521 aggtaaggca aatatgtatg ctgtagcaaa agaagttttg cgtctaaatg aaaaacttga
     2581 tttaggttct gttcgtcaac ctttagaagc attggcagaa ggtgacttgg aagttgcaaa
     2641 acaagcagca gaacttattc aacaagcacg aaaagaattt ttataataaa taaaatcaat
     2701 atggagatat gttatgggca caacaggatt tacaataatt gacttaatta tcttgattgt
     2761 ttatttactt gcggtgttgg ttgcaggtat ctatttctct aaaaaagaga tgaaaggaaa
     2821 agagttcttt aaaggagatg gttcggttcc ttggtatgtt acttcggtat ccatttttgc
     2881 cacaatgctc agtccgattt ccttcttggg actcgctggt agctcttatg caggtagctg
     2941 gattttatgg tttgctcaat tagggatggt agtagctatt ccactgacaa ttcgttttat
     3001 cttacctatc tttgcacgga tagacatcga tacggcatat gattacttgg ataaacgttt
     3061 taattctaaa gcacttcgta ttatttcagc actcttgttt attatttatc aattgggacg
     3121 tatgtctatc attatgtacc tcccatcagc tggtttatca gtattgacag gaattgacat
     3181 caatattttg attattttga tgggtgtagt tgcaattgtt tattcttata ctggtggtct
     3241 aaaatccgta ttatggacag actttattca aggtgtgatt ctgattagtg gtgtcgtttt
     3301 agctttattt gtactgattg ctaatattaa aggtggcttt ggtgcagtag cagaaacatt
     3361 agcaaacggg aaattccttg ctgcaaatga aaaacttttc gatcctaact tgctttcaaa
     3421 ctccatcttt ttaattgtga tgggttcagg ctttacaatc ttgtcttcct atgcttcatc
     3481 tcaagatttg gttcaacgtt ttactacaac acaaaatatt aagaaactta ataagatgtt
     3541 gttcacaaac ggtgttttgt cacttgcaac tgcaacagtc ttttacttga ttggtacagg
     3601 cttgtacgta ttctatcaag tacaaaatgc agatagtgca gctagcaata tccctcaaga
     3661 ccaaatcttt atgtacttta ttgcatacca gttaccagta ggtatcacag gtttgatctt
     3721 ggcagcgatt tatgcagcat ctcaatcaac tatttcaaca ggtttgaact ctgttgcaac
     3781 ttcatggaca ttggatattc aagatgtcat ttctaaaaat atgtcagaca atcgtcgtac
     3841 gaaaattgca caattcgtat ctctagcagt aggtttattc tcaattggtg tttccattgt
     3901 catggctcac tcagatatta aatctgcata cgaatggttc aatagtttca tgggacttgt
     3961 acttggtcta cttggtggtg tatttattct tggatttgtt tctaaaaaag caaataaaca
     4021 aggtgcttat gcagcgctga ttgtatcaac catcgtcatg gtatttatta aatacttcct
     4081 tcctccaaca gctgttagct actgggcata ttcattgatt tcaatctctg tatcagtagt
     4141 ttcaggttat attgtatctg ttcttactgg aaataaagta tctgcaccta aatatacaac
     4201 gattcatgat attacagaaa ttaaagcgga ttcaagttgg gaagttcgtc actaatagaa
     4261 aagagaaaat aatatgatta tttctgaaca atctgatttt aaacgatatg cttctgtcaa
     4321 taaatatttt tcaaaagtct gtgatttttt agaaaataca aatttgacag atttagttga
     4381 tggaaaaatt gatattgacg gggaaaatgt ttttgcaaat tgtatgactt atctagctga
     4441 tggagttcca ggagatattt ttgaaactca taagaaatat ttagatattc atattgttgt
     4501 tgaaaatact gaaaaaatgg cagtaacttc cccagttcgt gcccagtcac gtgtaccttt
     4561 tagcgaagag aaggatattg ctttttacga tagcaaagac tatcaaattg ttgaattgct
     4621 tccagggaat atgttggtga cttttgaaga agatcttcac caaccaaaga ttcattgcaa
     4681 tgatgaaact gttaaaaaac ttgttatcaa agttttaaac gaggaaaaat aaaatgaaaa
     4741 aaaatattaa acaatatgta accttaggta ctgtagtggt attatcagca tttgttgcta
     4801 actcagttgc agctcaggag actgaaactt ctgaagtatc aacaccaaag ttggtgcaac
     4861 ctgttgcacc aacgactccg atttcggaag tacaacctac atcggataac tcttcggaag
     4921 ttactgtaca acctcgaaca gttgaaacta ctgttaagga tccatcttct acagcggaag
     4981 aaactcctgt cttagaaaaa aataatgtta ctttaacagg gggcggagaa aatgttacta
     5041 aagagttaaa ggataaattt actagcggtg actttactgt agtgattaag tacaatcagt
     5101 caagtgagaa aggcttacaa gctctgtttg gaatatctaa ttccaaaccc ggtcaacaaa
     5161 atagttatgt agatgtgttc cttagagaca atggtgagtt ggggatggaa gcgcgtgata
     5221 cttcttccaa taaaaataac ctagtatcca gacctgcttc agtttggggt aagtacaaac
     5281 aagaggctgt gactaacact gttgcagtag tagcagattc agtcaaaaaa acatattctt
     5341 tatacgcaaa tggtacaaaa gtagtagaaa agaaagtgga taatttccta aacatcaagg
     5401 atattaaagg tattgattac tatatgcttg ggggagtgaa acgtgcagga aaaacggcgt
     5461 ttggttttaa cggaacacta gaaaatatca aattctttaa tagtgcattg gatgaagaaa
     5521 ctgttaaaaa gatgacaaca aacgctgtta ctggacattt aatttatacg gctaatgata
     5581 caacaggttc taactatttc cgtattccag ttctgtatac ttttagcaat ggtcgggtat
     5641 tttcaagcat tgacgctcgt tacggtggaa ctcatgattt cttgaataaa attaatattg
     5701 ctacaagtta tagtgatgat aatggtaaga catggactaa accaaaatta acattggcat
     5761 tcgatgattt tgcgccagta ccattagaat ggcctcgtga agttggtgga cgtgacttac
     5821 aaatcagcgg tggtgcaacc tatattgact ctgttattgt tgaaaaaaag aacaaacaag
     5881 tactcatgtt tgctgatgtg atgcctgctg gagtaagttt tagagaagca actagaaaag
     5941 attcaggtta taaacaaatt gatggtaatt attaccttaa attaaggaaa caaggtgata
     6001 ctgattacaa ttatactatt cgtgagaatg gtactgtata cgacgatcgt accaacagac
     6061 caactgaatt ttcagtagat aaaaatttcg gtattaaaca aaatggtaat tatttgacgg
     6121 tagagcaata ttcggtttca tttgaaaata ataaaaagac tgaatatcgt aatgggacta
     6181 aagtccatat gaatatcttc tacaaagatg cattgtttaa agtagtgcca acgaactata
     6241 ttgcatatat ttctagcaat gatcatggcg aatcttggtc tgcaccaact ttattacctc
     6301 ctataatggg acttaatcgg aatgcgccat atttaggtcc tggacgtgga atcattgaaa
     6361 gctcaactgg acgtattctt attccgtctt acactggtaa agagtctgcg ttcatttata
     6421 gtgacgataa tggagcatct tggaaagtta aagtagtgcc acttccttct agttggtcag
     6481 cagaagcaca atttgtagaa ttgagtccag gagtaattca agcatatatg cgtacaaata
     6541 atggtaaaat tgcatattta acaagtaaag acgcaggtac tacttggagt gcaccggaat
     6601 atttgaaatt tgtttcaaat ccaagttatg gaacacaatt atcaatcatc aattatagcc
     6661 aattgattga tggtaaaaag gctgtcattt taagtactcc aaactccaca aatggtcgta
     6721 aacacggaca aatttggatt ggtctaatta atgatgataa tacaattgat tggcgttatc
     6781 atcacgacgt tgattatagt aactatggat actcatattc aacattgaca gagttaccaa
     6841 atcatgaaat tggattgatg tttgaaaaat ttgattcatg gtctcgtaat gaacttcata
     6901 tgaaaaatgt tgtaccatat ataacattta agattgaaga tctgaaaaag aattaaagct
     6961 gaaatttgaa aatatataaa aagaggataa aaattatggt aaattacggt attgttggag
     7021 ctggatattt tggagctgat ttagctcgct caatgaacaa aattgaagat gcaaaagtgg
     7081 ttgcggtatt tgacccaaat catggagaag aagttgctca agagttggga tcagatgttt
     7141 gtgcaagttt agatgaactt gtagcacgtg aagatattga ttgtgtgatc gtagcttcac
     7201 ctagctacct tcaccgtgaa ccagttgtga aagctgctca acatggcaaa cacgtatttt
     7261 gtgaaaagcc aattgcattg tcttatgaag attgtaaagc catggttgac gcatgtaaag
     7321 aaaataatgt catctttatg gctggtcaca tcatgaactt ctttaacggt gtacaccatg
     7381 ctaaagaatt gattactcaa ggtaaaatcg gtaaagttct ttattgccat gctgctcgta
     7441 caggttggga agaacaacaa ccaactgtat catggaagaa acttcgttct caatctggag
     7501 gacatttgta ccaccatatt catgaattag attgcattca gtttatcatg ggaggacttc
     7561 ctgaaaaagc gacaatggta ggaggcaatg tatatcataa aggtgaaaac tttggtgatg
     7621 aagatgatat gctcattgta aacttagaat actctgatga tcgttatgct gttttggaat
     7681 atggtaatgc tttccgttgg ggtgaacact acgtcttgat tcaaggaact gaaggagcta
     7741 tcaaacttga cttgttcaat actggcggta ctcttcgtgt taaaggtgaa ggagaatcac
     7801 acttcttagt tcatgaaact caagaggaag atgatgatcg tacagctatc tataccggtc
     7861 gtggtatgga tggagcaatt gcgtacggta aaccaggagt acgttgccca ttatggttgc
     7921 aaacatgtat tgataaagaa atggaatatc tacatgacat cattaaaggt ggagaaatta
     7981 cagaagaatt tgaaaaactt ctcaatggtg tagctgcttt agaatcaatc gctaccgctg
     8041 atgcatgtac tttatcagtt aaagaagatc gaaaagtaag tctttcagaa atcacaaatg
     8101 cttaactttt gtaaaacaga atagtaaatt cttgtcatta tataatttct aaagttctgt
     8161 gatacaactc attgaataaa gaaatagaga tgggactggg ataatgccca gtcccatttt
     8221 ttatcaaaaa gtaatgagat caaaaatgtg ggagtgttga aatgaagatt ataggtatcg
     8281 atattggcgg aacaacaatt aaggcagatt tatacgatga gtttggaacg agtttgaatc
     8341 atttcaaaga gatagaaaca attattgact atgatttggg aacgaatcag atattaaatc
     8401 aggtctgtga tttaattggt gagtatactt taaatcattc aattgatggt gttgggattt
     8461 ccactgctgg agttgttaat gctaatactg gagaaatcat ctatgcaggc tatacaatac
     8521 cagggtatat cggagtaaac tttactgccg aaatagaaaa acgttttggg ttgtatactt
     8581 ttgttgaaaa tgatgttaat tgtgctgcat taggtgaatt gtggaaggga caagccaaag
     8641 ataagaaaaa tgtagtaatg gttactattg gaacaggtat aggaggcagt attattgtca
     8701 acggacaaat tgttaacgga tttaactata ctgctggtga agtaggttat attcctgtag
     8761 gtaattcgga ttggcaaagt aaagcctcaa caaccgcatt gattcattta tatcaaaaaa
     8821 agagcttgaa aactaatcaa actggacgta ctttcttcac tgatttaaga tctggagata
     8881 aagttgctga agaaactttt gaaatttttg tagaaaatct aacaaaaggt ttattaacga
     8941 tttcttatct acttaatcca gaaattctca tattaggagg tgggattctg gatagtaagg
     9001 atattttgtt acctgaaatt caaagttctt tagctaaaaa tgcaatggat aataggtttt
     9061 tacctaaaaa tcttgtggca gctacattag gaaatgaagc tggtcgtata ggagctgtaa
     9121 aaaatttctt agatagaatt tctaataaat agtatgtaag ataaggaggt gtcacaatga
     9181 ctaactctgt attttcgaca atgcaagata ttgagaatgt tgcaaccgat attataaaat
     9241 catatgataa tgagatttat acttataaag ctgtttccca agaagaattg gaaaaactag
     9301 aaaaaagtta tgatgaaaaa agtcacgaag aattagtttc aatagaaagc aatttagaaa
     9361 tgaaacaaca gaaccttatt gatgaggtta ataaaacaat caaggaaaat gatgcaaata
     9421 ttcagtatat ttcatcaagt aggagaggag aatttgtaga aaaaattatt ggtagggtgg
     9481 tagaaaaata tggccattag tcagatgaaa agaatctctc tactattttc taaaagtagt
     9541 cttgatgatg ttttaaaaac tattcaagaa ctagagtcag tgcagttccg tgatttaaag
     9601 gttcaggata actggtcaga agctctagaa aaagatgaag ttgtatttcc aactattcaa
     9661 atttttcata cttctaattc caatcatggg gttattgagg gaaatgatgc cttgacttat
     9721 ttgatgaatc aacaacaaca tttagaagca actgtagaga aattacaaga atacctaccg
     9781 aaagaaaaca cgtttaaatt attgcagcaa cctccgataa ctacctctta tgaagaatta
     9841 gagaaatttg gtaaagctaa tgttgctgag ggtgttctta aaaaagtgaa tcatcaaatt
     9901 aacagagttc atgaattaga aagacacatt caaagtaata atgaggaaat agagcgatta
     9961 ataaagtggg aaaaattaga aattgttcct gcgaatttag aacaattttc tttctgtaaa
    10021 ggaaaagtcg gaacaattcc aaggactgaa gataatcgct tatacaatag tcttttagaa
    10081 aacaatattg aagttcaaga aatattttct aatgatagag agtacggtgt tgttgttttc
    10141 tatcagtcta gttactctat agattttgat gaatacttat ttgaaccatt tgattattct
    10201 agaaaggaat taccgaagca gcgagtagta gatttagatc aagaaaacat gcagttaata
    10261 actgaaaaag agaatattat cgcatcgttg caagattcaa agaaatattt gatagattta
    10321 caatggcaaa tagactatat tttatctatc tatgctcgtc aaatctctaa gaataacttt
    10381 ttgtgcactc cgcatctagt tgcattagaa ggatggatag aagaaactcg tattttatat
    10441 tttataaaag ttatggatga gcattttgga cattctattt atatttatga atcggaaaca
    10501 ttgacggata atcaagatga aatacctatc aaattaacga atcattcttt aattgaacca
    10561 tttgaattat tgacagaaat gtatgctctg cccaaatatt atgagaaaga tcctacacct
    10621 gtattagcac cattttactt tacatttttt ggaatgatgg ttgctgattt aggctatggt
    10681 ttactattgt ttttaggaac aatgttagca ttaaaaattt ttcatctacc ttcagcaact
    10741 aagagatttt taaaattctt taatatatta ggggtagccg ttgcaatttg gggtggaatc
    10801 tatggctcat tttttggata tgagttgcca tttcatctga tatctacaac ctctgatgtc
    10861 atgactatat tagtagtgtc agttgtgttt gggtttatta cagtatttgc aggtttgtta
    10921 gcttcaggac tacaaaaagt aagaatgaag aaatatgcag aagcatataa ttcaggattt
    10981 gcgtggtgtg ttattctgct tggcttgtta tttattgctg ttggaatgtt gatgcctgat
    11041 atgagaccgt tatttgtatt agggaaatgg gtatctattt ttaatgctgt ggggattttg
    11101 attgtttcta ttattcaaac caaaagcttg tcaggtattg gagcaggatt gtttaatcta
    11161 tataacattt catcttatat aggtgattta gttagtttca ctcgattgat ggcattagga
    11221 ttatctggag caagtatagc atcagctttc aatttaattg ttggtttgtt tccgggaata
    11281 ttggctaaac tgacaattgg attagtatta ttcattcttt tacatgcgat caatattttt
    11341 ctatcgttac tatcaggata tgttcatgga gcacgtctga tatttgttga attttttggt
    11401 aagttttatg agggtggagg aaaaccattt caacctttga aggcttctga gaaatatatt
    11461 aaggttatta caaagaatta atggaggata tatataatgg aacatttagc aacttatttt
    11521 tcaacctatg gaggagcttt cttcgctgca ttgggaattg tattggcggt tggattaagc
    11581 ggtatggggt ctgcttatgg agttggtaag gctgggcaat ctgccgcagc tttactgaaa
    11641 gaacagcctg aaaagtttgc ctcagctttg atattgcaat tattgcccgg aacacaagga
    11701 ttatatggtt ttgttattgg aattttaatt tggttgcaat taactccaga acttccttta
    11761 gaaaaaggcg ttgcttattt ctttgtagct cttccaattg ctattgtagg atacttttca
    11821 gctaagcatc aaggaaatgt agcagtagcg ggaatgcaaa tcttggctaa aagaccaaaa
    11881 gaattcatga agggagcaat tttagctgcc atggtagaaa cctatgcaat tcttgctttt
    11941 gtcgtatcat tcattttgac ccttcgtgta taagaaataa atttgcaatt caaaggaggt
    12001 gtctaaatga gcaatttaga aaacttacga gagtctgtta ttgaacaagc tcatgaaaaa
    12061 gggcgtatga aattattgga ttccaaaaag aagattgatg atgaatttga aatgcaaaag
    12121 tcgctcatta taaagaaaaa agaagctgaa catgaacgaa agttaaaaga attgcaacag
    12181 aaatatcaaa taatttttca acaattaaaa aataaggaac gccaatcaac gttagtatca
    12241 aaacagaaaa tattaaaaga actttttcaa tctgctttac tagaaatgga atcttggagt
    12301 gcagataaag aaatggagtt catctatcga attctggaac gatattcaca acaagaggtc
    12361 atagtaacct ttggggaacg gactttagct aaattcaatt tggaacaatt agagaaattg
    12421 aaattctctt ttccaaatta tttatttagt gaacaaccta tctcaaatga atcaggctta
    12481 cttatttcaa taggtaaaat tgatgataac tatttgtata aaacattaat tggatcgatt
    12541 tctaaggaag aaagttcaag tatcgcaaat caaattttta tcaattaagg atgaaattgg
    12601 ttaatccttc ttagaaattt ggagtattcc aataaaatta gaaaggtatt ttatggatac
    12661 taatcttttt tcaaaaataa atacgacgat ttcggtaaaa gaaaacgatt ttattacaga
    12721 agaaaaattt caaaaaatta tacaatccaa agatacggag acattggcat ttatcttaga
    12781 atcaactccc tatcatttat cgattgacat cttagaagat cctagtcaga cagagatttc
    12841 gctaatgaca aaattagtca atgattatag atgggcctat gctgaaagtc cgtctgatat
    12901 aattgtgact ttatttgctt tacgatatgt ttatcataat atcaaagttt tattaaaatc
    12961 taaggcggca attaagaaag atttttctaa attattaatt ccaataggga tttttgatat
    13021 agaaagttta aaacatttag tttcttcctt acattcagat acacttcctg attttatggt
    13081 tcgtgaagta gaatcaattt ggaatgagta tgaaactttt aataatattc gtgtacttga
    13141 tgtcggagct gatctagcat attttaaaca tctgaaactt ttatctaatg agttagatga
    13201 ggtactgtct caggttattg tcgaaatgat tgacttttat aatattatta ctgtaaaacg
    13261 tggtttatct caaaataaga gtcatgggga tattttacaa ttactttcag atgaaggaag
    13321 tatttctgct aaagaattta tatacattgt agaaaatcaa gaaatatttg tgtggttcaa
    13381 taaaataaat ccaagcttag attcaatctt ttcaacttat gaattgaaga tgcaggacgc
    13441 aacaatttca tcttctgagt tagaattttt atgtgattta ctattgtata aaactttaga
    13501 tcaaggaagg tacaatgtag aggggccgtt agttcttgct agatatttat tgggatgtga
    13561 gtttgaagta aagaatctca gaatgatcat atcagctctt caaaatacaa ttccctttga
    13621 atcaataaaa gaaaggatac gcccacatta tggaagctaa taagtataaa attggcataa
    13681 ttggtagccg tgatattatt ttaccattta gcatgattgg gtttgatata tttcctgcct
    13741 accaagaaca agaagctata aatacactaa gaaaattagc tcaatctgat tatggtgtca
    13801 tttatatcac tgaagacatt gcttcaatga tattagatac aattcgccat tatgattccc
    13861 aagttgtgcc tgctattatt ttattaccga ctcataaaca aggtttaaat ttaggattaa
    13921 aacgtataga ggataatgta gagaaagcag taggacacaa tattttataa taatgtacaa
    13981 aattgtctgt aatattattc tataattttt ggacttagta aggagaataa ctttgactca
    14041 agggaagatt ataaaagtat cgggacctct agttattgca tcaggtatgc aggaggctaa
    14101 tattcaagat atttgccgtg taggtaagct agggttaatc ggtgaaatta ttgaaatgag
    14161 aagagatcag gcatctatcc aagtctatga agaaacatct ggtcttggtc cgggagaacc
    14221 tgttgttaca actggagaac ctctctcggt tgaattaggg ccaggattga tttctcaaat
    14281 gtttgatggc atacaacgcc cattagatcg atttaaattg gctactcata atgattttct
    14341 agttcgtggg gtagaagttc caagtttgga tagagatatt aagtggcatt ttgattccac
    14401 tatagcaatt ggtcaaaaag tgagtacggg tgatattctt ggaactgtca aggaaaccga
    14461 ggtagttaat cataaaatta tggttcctta tggagtatct ggagaagtcg tttctattgc
    14521 atctggcgat tttacaattg atgaagttgt atatgaaata aaaaaattgg acggtagttt
    14581 ctataaagga acgcttatgc aaaaatggcc tgtccgcaag gcgcgtcctg tttctaaacg
    14641 tttaattcca gaagaaccat taatcacagg tcaacgagtt attgatgcat tctttccagt
    14701 aaccaaaggg ggagctgcag cagttcctgg accgtttgga gcaggaaaga cagttgtaca
    14761 acaccaagta gctaaatttg ccaatgttga tattgttatt tatgtcggtt gtggagaacg
    14821 tggaaatgaa atgacggatg tactgaatga gtttcctgag ttgattgacc ctaataccgg
    14881 acaatcaatt atgcaacgga cagttctgat tgctaatact tcaaatatgc ctgttgctgc
    14941 tcgtgaggct tcaatttata caggaattac catggctgag tattttcgtg atatgggcta
    15001 ctctgtcgcc attatggctg attcaacttc acgttgggca gaagcgctac gtgaaatgtc
    15061 aggacgtcta gaagaaatgc ctggtgatga gggttatcct gcttatctgg gaagtcgtat
    15121 cgctgaatat tatgaaagag caggacgttc tcaggttcta gggcttccag aacgtgaagg
    15181 aacgattact gctattggag ctgtatcgcc acctggtgga gatatttcag aaccagttac
    15241 tcaaaacact ttacggattg tgaaagtttt ttgggggctt gatgctccgt tggcacagcg
    15301 acgtcatttt cctgcaatta actggcttac atcttattca ctatataaag acagtgtggg
    15361 cacttatata gatggtaaag agaagacaga ttggaatagt aaaataactc gtgcgatgaa
    15421 ctacttacaa cgggaatcta gtttagagga aattgttcgt cttgttggaa ttgattctct
    15481 gtctgataat gaacgactaa cgatggaaat tgctaaacaa attcgagaag attatttgca
    15541 acagaacgct tttgattcgg tagatacatt cacttcgttt gcaaaacaag aagcaatgct
    15601 aagtaatatt ctcacttttg ctgatcaggc aaatcatgct ttagagttgg gttcttactt
    15661 tacagagatt atggaaggta ccgtggcagt tcgagaccgt atggcgagaa gtaaatatgt
    15721 ttcagaagat agattagatg aaatcaaaat tatatcaaat gagattacac atcaaattca
    15781 tttgatatta gaaacaggag gtctataaat gagtgttata aaagaataca gaactgctag
    15841 tgaagttgtt gggcctctta tgattgttga acaagtaaat aatgtgtctt acaatgagtt
    15901 agttgaaatt caacttcata atggagaaat tcgtcgtgga caagttttag agatccacga
    15961 agataaagca atggttcagc tttttgaagg atctagtgga ataaatttag aaaagtctaa
    16021 aattcgtttt gctggtcatg cattagaatt ggctgtatct gaggatatgg ttggtcgtat
    16081 ttttaatggg atgggaaaac caattgatgg tggaccagat ttaattccag agaaatattt
    16141 agatattgat ggtcaagcta ttaatcctgt atctagagat tatccagatg aatttattca
    16201 gacagggatc tcctctattg atcatttgaa tactcttgta cgtggtcaaa aattaccagt
    16261 attttcaggt tcgggcttac ctcataatga attagctgct cagatagcaa gacaagcgac
    16321 tgttttaaat tctgatgaaa attttgcggt tgtatttgca gcaatgggta ttacttttga
    16381 agaagctgag ttttttatgg aagaactcag aaaaacagga gcgatcgatc gttcggtttt
    16441 atttatgaac ttggcaaatg atcctgcaat tgagcgtatt gcaactcccc gcattgcttt
    16501 aactgcggca gagtatctag cttttgaaaa agatatgcac gttctagtta tcatgacgga
    16561 tatgactaac tattgtgaag cgttacgtga agtctcggca gctcgccgtg aagttccagg
    16621 gagacgaggc tatccgggat atttatatac aaatttatca actctatacg aaagggctgg
    16681 tcgcttagtt ggtaaaaaag gttcggtgac acagattcct attttaacaa tgccagaaga
    16741 tgacataaca catccaattc ctgatttaac tggatacatt actgaagggc aaattatttt
    16801 gtcgcatgag ttgtataatc aaggttatcg tccaccaatc aatgttttac cttctctctc
    16861 tcgattaaaa gataagggat ctggagaagg taaaactcgt ggagatcatg ctccaactat
    16921 gaatcaactg tttgcagcct atgcccaagg gaaaaaggtt gaagagttag cagtagtatt
    16981 aggagaatcg gctttatctg atgtagataa attgtatgtg aggtttacaa agcgttttga
    17041 agaagagtac ataaaccaag gattttataa aaatcgaaat atagaagata cgttgaatct
    17101 tgggtgggaa ttactatcaa ttcttcctag aacagagtta aaacgtatca aagatgattt
    17161 gcttgataaa tacttacctt tggtagaagt ttaatccgga aatggagtga ttatctatgg
    17221 tacgtttgaa tgtaaaacca actcgtatgg aattgaataa cttaaaggaa cgtttgacaa
    17281 cagctgaacg tggacataag ttattaaagg ataaaagaga tgaattgatg aggcgattta
    17341 tttctttgat tcgtgagaat aatcaacttc ggaaagaagt ggaaagttat ctaattgata
    17401 atctaaaatc ctttgcagtt gctaaatcat taaagaattc tcaaatggtg gaggaattat
    17461 tttcaattcc atcgaaagaa attgaattat ttgttgagaa agaaaatatc atgagtgtaa
    17521 cagttcctag aatgcatatg aatattactt ctcaaaatga gaacagtgaa tacagctatt
    17581 tatcttctaa tagtgaaatg gatgatgtat ttgctacaat gaatagttta atttataaat
    17641 tactaagact ggcagaagtt gaaaaaacgt gtcagttaat ggctgatgaa atagaaaaaa
    17701 cacgtagacg tgtaaatggt ttagaatact cgattattcc aaacttgtcg gaaactattc
    17761 attatataga attgaaacta gaggaggcag aaagagccaa tttagttcgt attatgaaag
    17821 tgaagtagat cctttattta gattattaat tagatgaaca aatatcagct tggataaggc
    17881 tttaagcctt tctaagcttt ttttattgac agtatcagga tatctttttc aaaattttgg
    17941 tttgttagat aatgaaaatg tttctactaa tctagattta ggattagtaa atcgtaaatg
    18001 taattatata gaaagtaagc gcgtcataac aaggtatcta tcattcatgg agctcctcct
    18061 gtatactatt agtaaagtaa aactattgga ggatatttta atgccacaac ctattgttcc
    18121 tgtagagatt ccacaatctc gtcgttttga ttctaaaaag agaaatgata ttctgcttaa
    18181 aattcgtatt ggcaagcttg aagtaagttt ttttcaatct ctcaatctcg aaatggtaga
    18241 acagcttttg gataaggtgt tgctctatga caattcatct atctagccta ggggaggtct
    18301 atctcgtgtg tgggaaaact gatatgagac aaggaatcga ttcactggct tatctggtta
    18361 aaacccactt tgaattggat cctttctccg gtcaagtctt tctcttttgt ggtggacgta
    18421 aagaccgctt taaagtcctt tactgggatg gtcaaggatt ttggctacta tataaacgct
    18481 ttgagaacgg cagattgatt tggctaagta cagaaaagga tgtcaaagct ctcacaccag
    18541 aacaagtaga ctggcttatg aagggctttt ctatcactcc aaaaatatag tagattgaaa
    18601 ctagaatagt acacctctgc ttctaaaaca ttgttagaaa tcgattttac tgtcctgatc
    18661 gatttgtcct gttcttattt cattttacta taaatccatc agaaagtcgt gatttctatt
    18721 gaaatgagga ctttcttttt atactcatct gctttcaaaa agcattctag tccatctccg
    18781 attaacgatg gactttatca cctccttctc cagtccttgt ataacatctt ggagttgatt
    18841 catgacatct tccaaagttt aaaaggcttt attcttaaat ccacgtttac gaatctcttt
    18901 ccacacttgt tcaatggggt tcatctctgg tgtgtatgga ggaataaatg caaagccaat
    18961 attagtcgga atctttaagg tacttgattt atgccatata gcattgtcca taacgagtaa
    19021 aagataatca tctggataag cttgtgaaat ctcctattcc taaagcccct ttagcgcata
    19081 actttggctc agcttctatt atcgctcaca ccatccatca gaagtttaat ctgaaggtac
    19141 ccaattatcg ccaagaagaa gattgggcta ggatgggttt accaatcaca cgtaaggaaa
    19201 tctctaattg gcatatcaag gcgagtcaat actatttgga gcccctttat aacctcttgc
    19261 gagagagact attgactcag cccttacttc atgcggatga aacttcttat agggtgctag
    19321 agagtgatag tcagctgact tactattgga cttttttgtc aggtaaagca gagaaacaag
    19381 ggattacgct ttaccaccat gatcagtgtc gaagtggttc agtagtacaa gaattcctag
    19441 gagattattc tggctatgtg cattgtgata ttttgcggca gtaacttagg actttagtcc
    19501 tctagttctg cctatgcgat agcagtccaa ggtttaggag caaggcgacg ctaagcttgg
    19561 taaacttcga accgctcgtc tgcttatcgt caactggaag aagctgaact tgttggatgt
    19621 tgggcgcatg tgagaaggaa gttttttgaa gcgccccccc aagcaagcgg ataaatcatc
    19681 cttaggagct aaaggtttag cttattgtga tcagttattt tccttggaaa gagactggga
    19741 ggctttgcca gctgatgaac gactacagaa acgtcaagaa catctccagc ccttaatgga
    19801 agacttcttt gcttagtgcc ggcgtcagtc agttttagca ggttcaaaac taggaagggc
    19861 aattgaatac agcctcaagt atgaagaaac ctttaagacc attttgaaag acggacatct
    19921 ggtcctttcc aataatctag ctgaacgcgc cattaaatca ttggttatgg gacggagtaa
    19981 aagagtccag tggactcttt tagcctaagc tcagtttaaa aaagcgaggg tggttatttt
    20041 ctcaaagttt tgaaggagct aaagcaagag ctattattat gagtttgttg gaaacagcta
    20101 aacgtcatca attaaatagc gagaaatatc tatcctatct tctagaatgt cttccaaacg
    20161 aggaaactct cgtaaacaaa gaggttttag aggcttattt accatggact aaagttgtac
    20221 aagaaaagtg caaataagaa atctccagat taggaactat ccgtgagttc tccagtctgg
    20281 agatttttca atagacttcc tgcgaaacaa aatatggtat aatagttcta tgaatgatga
    20341 agcaagta
//
LOCUS       DBERMM010000036        19528 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.036, whole genome shotgun sequence.
ACCESSION   DBERMM010000036 DBERMM010000000
VERSION     DBERMM010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 19528)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19528)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19528
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.036"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(1..619)
                     /locus_tag="ACL8AS_001579"
                     /pseudo
     CDS             complement(1..619)
                     /locus_tag="ACL8AS_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365310.1"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
     gene            complement(728..1246)
                     /locus_tag="ACL8AS_001580"
     CDS             complement(728..1246)
                     /locus_tag="ACL8AS_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ClbS/DfsB family four-helix bundle protein"
                     /protein_id="HGS1229410.1"
                     /translation="MRTYENKEELKAEIEKTFEKYILEFDNIPKNLKDKRADEVDRTP
                     AENLAYQVGWTNLVLKWEEDERKGLQVKTPSDKFKWNQLGELYQWFTDTYAHLSLQEL
                     KAKLNENINSISAMIDSLSEEELFEPHMRKWADEATKTATWEVYKFIHVNTVAPFGTF
                     RTKIRKWKKIVL"
     gene            complement(1283..1411)
                     /locus_tag="ACL8AS_001581"
                     /pseudo
     CDS             complement(1283..1411)
                     /locus_tag="ACL8AS_001581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267199.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CD1845 family protein"
     gene            complement(1473..2342)
                     /gene="rsmI"
                     /locus_tag="ACL8AS_001582"
     CDS             complement(1473..2342)
                     /gene="rsmI"
                     /locus_tag="ACL8AS_001582"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0000451 - rRNA 2'-O-methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HGS1229411.1"
                     /translation="MQIQKSFKGQSPYGKLYLVATPIGNLDDMTFRAIQTLKEVDWIA
                     AEDTRNTGLLLKHFDISTKQISFHEHNAKEKIPDLIGFLKAGQSIAQVSDAGLPSISD
                     PGHDLVKAAIEEEIAVVTVPGASAGISALIASGLAPQPHIFYGFLPRKSGQQKQFFDS
                     KKDYPETQIFYESPHRVADTLENMLEVYGDRSVVLVRELTKIYEEYQRGTISELLESI
                     SETSLKGECLLIVEGASQDVEEKDEEDLFLEIQARIQQGMKKNQAIKEVAKIYQWNKS
                     QLYAAYHDWEEKQ"
     gene            complement(2345..2662)
                     /gene="yabA"
                     /locus_tag="ACL8AS_001583"
     CDS             complement(2345..2662)
                     /gene="yabA"
                     /locus_tag="ACL8AS_001583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication initiation control protein YabA"
                     /protein_id="HGS1229412.1"
                     /translation="MDKKELFDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRLE
                     NSKLRERLGEVEADAPVKAKHVRESVRRIYRDGFHVCNDFYGQRREQDEECMFCDELL
                     YRE"
     gene            complement(2702..3592)
                     /locus_tag="ACL8AS_001584"
     CDS             complement(2702..3592)
                     /locus_tag="ACL8AS_001584"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HGS1229413.1"
                     /translation="MKQDQLKAWQPAQFDRFVRILEQDQLNHAYLFSGFFGSLEIAQF
                     LAKSLFCTDKVGVLPCEKCRSCKLIEQGEFPDVTLIKPVNQVIKTERIRELVGQFSQA
                     GIESQQQVFIIEQADKMHPNAANSLLKVIEEPQSEVYIFFLTSDEEKMLPTIRSRTQI
                     FHFKKQEEKLILLLEQMGLVKKKATLLAKFSQSRAEAEKLANQASFWTLVDESERLLT
                     WLVAKKKESYLQVAKLANLADDKEKQDQVLRILEVLCGQDLLQVRVRVILQDLLEARK
                     MWQANVSFQNAMEYLVLKEI"
     gene            complement(3589..4227)
                     /gene="tmk"
                     /locus_tag="ACL8AS_001585"
     CDS             complement(3589..4227)
                     /gene="tmk"
                     /locus_tag="ACL8AS_001585"
                     /EC_number="2.7.4.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004798 - thymidylate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006233 - dTDP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dTMP kinase"
                     /protein_id="HGS1229414.1"
                     /translation="MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGV
                     LIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSS
                     VAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDL
                     EGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK"
     gene            complement(4447..5244)
                     /gene="proC"
                     /locus_tag="ACL8AS_001586"
     CDS             complement(4447..5244)
                     /gene="proC"
                     /locus_tag="ACL8AS_001586"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004735 - pyrroline-5-carboxylate
                     reductase activity [Evidence IEA];
                     GO_process: GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HGS1229415.1"
                     /translation="MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIAN
                     FGGQTSNNEEIFEEADVIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKL
                     ASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSEIFCQLLAKAGLLVELGES
                     LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQH
                     PGVLKDQVCSPGGSTIVGVASLEAHAFRGIVMEAVHQAYKRTQELGK"
     gene            complement(5248..6510)
                     /locus_tag="ACL8AS_001587"
     CDS             complement(5248..6510)
                     /locus_tag="ACL8AS_001587"
                     /EC_number="1.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004350 - glutamate-5-semialdehyde
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_process: GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-5-semialdehyde dehydrogenase"
                     /protein_id="HGS1229416.1"
                     /translation="MVSRQEQFEQVQAVKKSINTASEEVKNQVLLAMADHLVAATEEI
                     LAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLEN
                     GLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
                     KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPV
                     IETGTGIVHVYVDKDADDDKALSIINNAKTSRPSVCNAMEVLLVHEDKAASFLPRLEQ
                     VLVADRKEAGLEPIQFRLDSKASQFVSGQAAQAQDFDTEFLDYILAVKVVSSLEEAVA
                     HIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQ
                     KLHARGPMGLKELTSYKYVVTGDGQIRE"
     gene            complement(6520..7629)
                     /gene="proB"
                     /locus_tag="ACL8AS_001588"
     CDS             complement(6520..7629)
                     /gene="proB"
                     /locus_tag="ACL8AS_001588"
                     /EC_number="2.7.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004349 - glutamate 5-kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 5-kinase"
                     /protein_id="HGS1229417.1"
                     /translation="MKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAMLHEAGHEL
                     ILVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQIVSAQILL
                     TQDDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDEVKVGDNDTLSAQVAAMVQ
                     ADLLVLLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTGGMLTKIK
                     AATIATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLAFYAQSQG
                     SIWVDKGAAEALSQHGKSLLLSGIVEAEGVFSYGDIVTVFDKESGKSLGKGRVQFGAS
                     ALEDMLRSQKAKGVLIYRDDWISITPEIQLLFTEF"
     gene            complement(7730..9613)
                     /gene="cbpE"
                     /locus_tag="ACL8AS_001589"
                     /gene_synonym="pce"
     CDS             complement(7730..9613)
                     /gene="cbpE"
                     /locus_tag="ACL8AS_001589"
                     /gene_synonym="pce"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine esterase CbpE"
                     /protein_id="HGS1229418.1"
                     /translation="MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSD
                     AIILESNGHFAMVDTGEDYDFPDGSDSRYPWREGIETSYKHVLTDRVFRRLKELGVQK
                     LDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGYDKVLQT
                     AAEKGVSVIQNITQGDAHFQFGDMDIQLYNYENETDSSGELKKIWDDNSNSLISVVKV
                     NGKKIYLGGDLDNVHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQ
                     TSDSLPWKNGVDSEYVNWLKERGIERINAASKDYDATVFDIRKDGFVNISTSYKPIPS
                     FQAGWHKSSYGNWWYQAPDSTGEYVVGWNEIKGEWYYFNQTGILLQNQWKKWNNRWFY
                     LTDSGVAAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYKGQW
                     YYFAPSGEMKTGWVKDKEAWYYMDSTGIMKTGEIEVAGHHYYLEESGAMKQGWLKKAN
                     DWYFYKTDGSRAIGWIKDKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVPIEKS
                     ATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNSSTSQDLTSSTSQSSETSVNKSE
                     SEQ"
     gene            complement(9616..10503)
                     /locus_tag="ACL8AS_001590"
     CDS             complement(9616..10503)
                     /locus_tag="ACL8AS_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HGS1229419.1"
                     /translation="MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKK
                     AKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTS
                     GTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLALAQELKDKKS
                     LRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLV
                     ELQLETGRTHQIRVHMAYIGHPVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTL
                     EFKADIPEIFKETLERLRK"
     gene            complement(10493..10954)
                     /gene="lspA"
                     /locus_tag="ACL8AS_001591"
     CDS             complement(10493..10954)
                     /gene="lspA"
                     /locus_tag="ACL8AS_001591"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HGS1229420.1"
                     /translation="MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSL
                     TYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLG
                     NFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN"
     gene            complement(10951..11859)
                     /locus_tag="ACL8AS_001592"
     CDS             complement(10951..11859)
                     /locus_tag="ACL8AS_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HGS1229421.1"
                     /translation="MNIQQLRYVVAIANSGTFREAAEKMYVSQPSLSISVRDLEKELG
                     FKIFRRTSSGTFLTRRGMEFYEKAQELVKGFDIFQNQYANPEEEKDEFSVASQHYDFL
                     PPTITAFSERYPDYKNFRIFESTTVQILDEVAQGHSEIGIIYLNNQNKKGIMQRVEKL
                     GLEVIELIPFHTHIYLCEGHPLARKEELVMEDLADLPTVRFTQEKDEYLYYSENFVDT
                     SASSQMFNVTDRATLNGILERTDAYATGSGFLDSDSVNGITVIRLKDNLDNRMVYVKR
                     EEVELSQAGTLFVEVMQEYFDQKRKS"
     gene            11852..12049
                     /locus_tag="ACL8AS_001593"
     CDS             11852..12049
                     /locus_tag="ACL8AS_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HGS1229422.1"
                     /translation="MFIFYPQLLYLFIIPYFRSFPKRKKEHPILLNYLHYLPFSRQSY
                     FQNQFKKISGYTPLQYRKEKR"
     gene            complement(12100..12771)
                     /locus_tag="ACL8AS_001594"
     CDS             complement(12100..12771)
                     /locus_tag="ACL8AS_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysostaphin resistance A-like protein"
                     /protein_id="HGS1229423.1"
                     /translation="MKKRAIQILLALSLIFYKSTWFWRLFNYLAKPYLPASREFFQIL
                     LLMESGVLLLAVIYLLVFAGKKTFHFKWQLRYFIYLLLGYITSYMSDFLFSYFISLSS
                     NQISLNETIEMIGRQELPYFLLIVCFIGPIAEELIYRGVLMTTFFKNSPWYGDVLLSA
                     IIFGYIHINFALTPLAFFIYASGGLILALLYRMTKNIYYPILVHILINITAFWDVWLL
                     LFSGS"
     gene            complement(12825..13046)
                     /locus_tag="ACL8AS_001595"
     CDS             complement(12825..13046)
                     /locus_tag="ACL8AS_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000602450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0924 family bacteriocin-like peptide"
                     /protein_id="HGS1229424.1"
                     /translation="MILMTKNINLTNEELELIQGGADPYGKEPNGYYPWKMEPVLTLL
                     VHGFCPRDTDDLGYIGGGNHLCKGSAARF"
     gene            13318..14127
                     /locus_tag="ACL8AS_001596"
     CDS             13318..14127
                     /locus_tag="ACL8AS_001596"
                     /EC_number="3.-.-.-"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HGS1229425.1"
                     /translation="MIKLLALDMDGTLLNEAKEIPQAHITAIHKAIEKGVKLVLCTGR
                     PLFGVLPYYKKLGLDLQNEYVIVNNGCSTHQTSDWGLVDWKELSPADIEYLYDLAEKS
                     DVQLTLFDESHYFVLGGKPNQVIENDAKLVFSDLTEISLEEATSGKFRMFQGMFLGTK
                     EQTDDFEQRFAEELCQRFSGVRSQPVIYEAMPLGTTKATALSRLAEILKIDSSEIMAM
                     GDANNDIEMLQFAGLGIAMGNASDYVKSLADAVTSSNEEDGVARAIEKYIL"
     gene            complement(14308..15183)
                     /gene="aguB"
                     /locus_tag="ACL8AS_001597"
     CDS             complement(14308..15183)
                     /gene="aguB"
                     /locus_tag="ACL8AS_001597"
                     /EC_number="3.5.1.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0050126 - N-carbamoylputrescine amidase
                     activity [Evidence IEA];
                     GO_process: GO:0009446 - putrescine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-carbamoylputrescine amidase"
                     /protein_id="HGS1229426.1"
                     /translation="MRNVRVATIQMQCAKDVATNIQTAERLVRQAAEQGAQIILLPEL
                     FEHPYFCQERQYDYYQYAQSVAENTAIQHFKVIAKELQVVLPISFYEKDGNVLYNSIA
                     VIDADGEVLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVWNTRYAKIGIGICWDQWFPE
                     TARCLALNGAELLFYPTAIGSEPILDTDSCGHWQRTMQGHAAANIVPVIAANRYGLEE
                     VTPSEENGGQSSSLDFYGSSFMTDETGAILERAERQEEAVLLATYDLDKGASERLNWG
                     LFRDRRPEMYRQITD"
     gene            complement(15193..16278)
                     /gene="aguA"
                     /locus_tag="ACL8AS_001598"
     CDS             complement(15193..16278)
                     /gene="aguA"
                     /locus_tag="ACL8AS_001598"
                     /EC_number="3.5.3.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0047632 - agmatine deiminase activity
                     [Evidence IEA];
                     GO_process: GO:0009446 - putrescine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="agmatine deiminase"
                     /protein_id="HGS1229427.1"
                     /translation="MMDSPKKLGYHMPAEYEPHHGTLMIWPTRPGSWPFQGKDAKRAF
                     TQIIETIAEGERVYLLVEQAYLSEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKG
                     KKLAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEALERPVYDAKPFVLEGGAIHSDG
                     QGTILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVA
                     AFVGPAEVVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTE
                     EDLPGYIYEEGEEERYAGERLAASYVNFYIANKAVLVPQFEDVNDQVALDILSKCFPD
                     RKVVGIPARDILLGGGNIHCITQQIPE"
     gene            complement(16275..17402)
                     /gene="nspC"
                     /locus_tag="ACL8AS_001599"
     CDS             complement(16275..17402)
                     /gene="nspC"
                     /locus_tag="ACL8AS_001599"
                     /EC_number="4.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016831 - carboxy-lyase activity [Evidence
                     IEA];
                     GO_process: GO:0045312 - nor-spermidine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carboxynorspermidine decarboxylase"
                     /protein_id="HGS1229428.1"
                     /translation="MKLEQVPTPAYVIDLAKLEANCRILQYVQEEAGCKVLLAQKAYS
                     LYKTYPLISQYLSGTTASGLYEAKLAREEFPGEVHVFAPAFKDEDMEELLGITDHIVF
                     NSERQLRKHGSRCREAGVSVGLRLNPQCSTQGDHALYDPCAPGSRFGVTIDKIPSDLL
                     DLVDGLHFHTLCEQGADDLQTTLKAVEEQFGPYLHEVKWLNMGGGHHITREGYDVDLL
                     ISEIKRIRKTYNLEIYIEPGEAIALNAGYLATEVLDIVENGMEILVLDASATCHMPDV
                     LEMPYRPPLRNGFEAQEKAHTYRLSSNTCLTGDVIGDYSFENPVQIGDRLYFQDMAIY
                     SFVKNNTFNGIGLPSLYLMDEQGDCSLLKAFGYQDFKGRLS"
     gene            complement(17402..18661)
                     /locus_tag="ACL8AS_001600"
     CDS             complement(17402..18661)
                     /locus_tag="ACL8AS_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000088792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="saccharopine dehydrogenase family protein"
                     /protein_id="HGS1229429.1"
                     /translation="MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLK
                     AKLEGKTSTKIETAALDADKVEEVIALIESYKPEAVLNVALPYQDLTIMDACLATGVH
                     YIDTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSG
                     FDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYW
                     EDGKWVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSY
                     LTHMKCLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGV
                     KDGVKKTIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEE
                     LDPDPFMEALNEYGLPWVVVENPQMVD"
     gene            complement(18658..19518)
                     /gene="speE"
                     /locus_tag="ACL8AS_001601"
     CDS             complement(18658..19518)
                     /gene="speE"
                     /locus_tag="ACL8AS_001601"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HGS1229430.1"
                     /translation="MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKI
                     LILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQI
                     DIVEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEYDYDIIINDATDPF
                     GHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQAFPISRVY
                     QAHIPTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGAFMLPKYVE
                     DILEEEEGKK"
BASE COUNT         5664 a         4501 c         3469 g         5894 t
ORIGIN      
        1 tgtaattctc aagctgtgag ttcattatga tttgtaaatc cgatatatct tcagcagcta
       61 aaaacacatt ttgaaatgtt ccaagtccgt tttcaccaaa actatattct ctcttactat
      121 acttactctt attattctct atatagttag agtcaaggtt cttaacctct tgaagttcat
      181 tttctttact tctgaggtta aaatctttta cttctgaagt taagtttttt gacttctgta
      241 agtcattttc ttttacctga aatatattca taaagtcttt aacataaatg atgttcggct
      301 taccaagtcc aagccttact ctttcgatca gtcctattcc tttttttaca tcaagctcat
      361 ctaatgtttt tatggcagtt ggctttgaga tatttcttct tttcataatt tcttcgacag
      421 taaaatagat aaatactctg ccttccttgt ctatccagtt attcttaaat gacattcctg
      481 tctatttaag aagtatggaa taaaggataa ttgcttctgc tgataagccc cgaaattctt
      541 ctctatcaac taatatctcc ggtactttta agaagttaaa tctttccgct tctctgttat
      601 aaaaatattc aaagtccatg caagatcacc tcccttctta aaaatttgca aagaaaaaga
      661 cgatagtttt tcttctatcg cctttggtaa ccatttttat gaaatttttt aaagttaaaa
      721 atataattta taatactatc ttcttccatt ttctgatttt agttctgaaa gttccaaaag
      781 gtgcaaccgt atttacatga ataaacttat acacttccca agtcgctgtt ttagtcgctt
      841 catcagccca ctttctcata tgcggttcaa ataattcttc ctcactcaac gaatcaatca
      901 ttgcagagat agaattaata ttttcattta attttgcttt caactcttgc agagataaat
      961 gagcgtaggt atctgtgaac cactgatata attcaccaag ttgattccat ttaaatttat
     1021 ccgatggtgt ttttacttga agcccctttc tttcatcttc ttcccattta agaaccaagt
     1081 tggtccaacc aacctgataa gcaaggtttt ctgctggagt tctgtcaact tcatcagctc
     1141 tcttatcttt taaatttttt ggaatattat caaattctaa aatatatttc tcaaatgttt
     1201 tctctatctc agcttttagt tcttctttat tttcgtatgt tcgcaaaaaa tcaccttctt
     1261 tctgatttat caatcctttg atttaaaatg accttatttt tctatttata ccttctaaga
     1321 acgctataac tgctgctcca accatcggta ttccgtatgg gcttaataaa aaacttaata
     1381 ccaaagcttc tataccaagt gatacatctt tatattatca tcactaatta agttaaacag
     1441 aaacagacag aattattaca tcctgtctcc ctttattgtt tttcttccca gtcgtggtag
     1501 gcagcgtaga gttgactctt attccactgg taaatcttag ctacttcctt aatagcttga
     1561 tttttcttca taccttgctg gatacgagct tggatttcta agaacaagtc ttcctcgtct
     1621 ttttcttcca catcctgact ggcaccttca acaatcagaa gacattcacc cttgagagac
     1681 gtttcagaga tgctttccag caattcagaa attgtacctc tttggtattc ttcatagatt
     1741 ttggtcaatt ccctgaccaa gacaacggag cggtcaccgt agacttctag catattttcc
     1801 aatgtatctg ccacacgatg gggcgattca taaaaaatct gagtttcagg atagtctttt
     1861 ttcgagtcga aaaattgctt ttgctggcct gattttctcg gtaaaaagcc gtaaaagata
     1921 tgtggctgcg gcgctaaacc actggcaatc aaggcggaaa ttcctgcaga ggcacctgga
     1981 actgtaacaa ctgcaatttc ttcctcaata gctgccttaa ccaaatcatg accagggtct
     2041 gaaatgctag gcaaaccggc atcagagacc tgagcaatac tttgccctgc tttcaagaaa
     2101 ccaatcaaat caggaatttt ttccttggca ttgtgctcat gaaaactgat ctgcttggtg
     2161 gaaatgtcaa aatgcttgag caaaagacct gtattgcgcg tatcctcagc agcaatccag
     2221 tccacttctt tcaaggtctg gatagcacga aaagtcatat catctagatt gccaatcggc
     2281 gttgccacta gatacagctt gccataggga gactgcccct taaaactttt ttgaatttgc
     2341 atgcctactc cctgtataac aactcatcac aaaacataca ttcttcgtcc tgctctcgac
     2401 gttgtccata aaaatcatta catacgtgaa atccatcacg gtaaatacga cggacacttt
     2461 cgcgaacatg tttggccttg acgggagcgt ctgcttccac ctcacccaag cgttctcgca
     2521 acttactatt ttccaagcga agagctgtat tttcttctac caagctcttg agatttttct
     2581 tgatggcttc cacatcggct aaggttacca ataattgttg ggaaaaatca tccagcgcgt
     2641 caaataattc ttttttgtcc ataaaacagc cctttccttt ctttatcatt catttttgag
     2701 tttatatttc tttcaagacc agatattcca tggcattttg aaagctgaca ttagcttgcc
     2761 acatttttct agcttctagt aaatcttgta gaatcactct tactcttacc tgcaagaggt
     2821 cctgcccgca gagaacttca agaatccgta aaacctgatc ctgtttttcc ttatcatctg
     2881 ccaagttggc taatttggca acctgtagat aactttcttt tttcttagct actaaccaag
     2941 tcagcaggcg ttcactttca tcgaccaagg tccaaaaact tgcctgatta gccaactttt
     3001 ctgcttcagc tcgcgattga ctaaacttag ctaaaagagt cgcttttttc ttaacaagtc
     3061 ccatttgttc taagagtaag ataagttttt cttcttgctt tttaaagtgg aagatctgag
     3121 tccgacttcg gattgtcggt aacatctttt cctcatcgct agtcaagaag aaaatataaa
     3181 cttcactctg gggttcttcg atgaccttga gcagagaatt ggctgcgttg ggatgcattt
     3241 tatccgcttg ctcgataata aagacctgtt gctggctttc aatccctgct tgagaaaact
     3301 gtcccaccaa ttccctaatg cgttctgtct tgatgacctg attgactggc ttaatcaagg
     3361 tgacatcggg aaattctccc tgttcaatca gcttgcaact tcggcatttc tcacatggta
     3421 agacgccaac tttatccgta caaaagaggc tcttagctaa aaattgcgct atttccaagc
     3481 ttccaaagaa acctgaaaag agataggcgt gattgagctg gtcttgttct aagatacgga
     3541 caaaacggtc aaactgagct ggttgccaag cctttagttg atcttgtttc atttggccaa
     3601 gcccattccg tcaaacaaga cagccttggt agtttccaca acttgctcca aagggagact
     3661 agcatcaatc ttgacaatgc gatttccctc tttatccaga agagaaaggt agccttgacg
     3721 aactttttta tgcaagtcca acccttccaa atccaaacga ttaacctcgc ggtcactatt
     3781 agcagcaata cgagccagcc cttcttccac ctcgatgtca aaatagagtg tcaaatcggg
     3841 tttgaggcca tctgtcgcaa actgattgag ccagtcaatg gcttcaatat ctaagccacg
     3901 accaaatccc tgataggcaa cagaactatc gataaaacga tccatgatga ccaacttgcc
     3961 agcttcaagg gctggaagaa ctttttccac caaatgctgt ctgcgactgg caatatagag
     4021 aagtagctct gttttagcat ccatctgagt atgacttgga tccaaaatca cttcccgaat
     4081 cttctcccca atcaagactc cgccaggttc acgggtcgtc aacacctcta ctcctttttc
     4141 ctctaaaatt ggtagcagag cctctaaaac actggtcttg cctgctccct ctggtccctc
     4201 aagagagact aaaaatcctt ttgacatgtc taactcattt cttttttact acttctattc
     4261 tatcaaaaaa ataggggttt gtgacaatct ttttgtcttc tcatttcata ctcaatgaaa
     4321 atcaaagagc aaactaggaa gctagccgca ggctgtactt gagtacggca aggtgaagct
     4381 gacgcagttt gaatttgatt ttcgaagagt atcaaccacc ataaaagagg cagataaaac
     4441 tacctcttat ttacctagtt cttgtgttcg tttataggct tgatgaactg cctccatgac
     4501 tatgcctcga aaagcatgcg cttctaagct tgctacgcca acaatagtcg aaccgcctgg
     4561 actacaaact tgatctttca aaactccagg atgttgctgg ctttctagga ccaattgccc
     4621 agctcctacc acagtttggg ctgccatttt caaggctgtt tctcgtggta atcccgtctg
     4681 aacacctgca tctgccaagg cctcaataaa gagatagaca aaggctggtc cacaacctgc
     4741 aagacctgtc gctgcattga ttaagctttc tcctaattca accaagagac cagccttggc
     4801 taaaagctga caaaagatct cactgtcctc agccctgcaa ttaggagaca aggcataact
     4861 aatcactcct tgcccgatag aagcaggggt attaggcatc atacgaataa ttcgatgttg
     4921 gcttgggata agacttgcta gtttttctaa ggtcaatcca gctgccatcg aaatcaaaag
     4981 aagactttct cttttttcaa ggatggtctg gtattgagaa agcagttcag aaaactgagc
     5041 aggcttaaca cctagaaaaa tcacatctgc ttcttcgaat atttcttcat tgttagaagt
     5101 ctgaccaccg aagttagcga tgaaagcatc caccttgact tgactacgat tggcaaggag
     5161 aatctcatct gacggtctag cctgcaagac agacttggct aaactagcac ccatattccc
     5221 caaaccgata aatccaatct tcatctctta ctcccttatc tgtccatcac cagtgaccac
     5281 atacttgtag ctagtcaatt ccttcaagcc catgggacca cgcgcgtgca atttctgagt
     5341 agaaatcccc atttcacaac caagaccaaa ttgtcctcca tctgtgaaac gagttgaggc
     5401 attaacatac accgctgcag agtccacttg atctgtaaag tatgctgcag cttcagcatt
     5461 ttccgtcaca atagcatccg aatgatgggt actgtgggat tcaatatgcg caaccgcttc
     5521 ttctaaactg ctcacaacct taacagctag aatatagtct aaaaactcgg tatcaaagtc
     5581 ttgtgcttga gcagcttgac ctgaaacaaa ctggcttgct ttgctatcta ggcggaattg
     5641 aattggttcc aacccagctt cttttcgatc tgcaaccagc acttgctcca agcgaggaag
     5701 gaagcttgct gccttgtctt catgaaccag cagaacctcc atggcattgc agacagaagg
     5761 acgactggtt ttggcattgt tgatgataga cagtgccttg tcgtcatctg cgtccttatc
     5821 gacataaaca tggacaatcc cagttcctgt ctcgataaca ggcacaatgg cattctcaac
     5881 tactgcatta atcaagccag ctcctccacg aggaatgaga aggtctagat agcccttggc
     5941 cttcatcata gcataactac tttcacggct agtatcctcc accagttgaa tcacatttgg
     6001 atgaatagta gtcgtctcca agcccttctt caaggctgtg acaatggcat gggttgtttg
     6061 ataggcatcc ttaccactac gaagaacaac cgcatttcca ctcttaagag tcaaagcagc
     6121 cgcatcagac gtcacatttg gacggctttc atagataata ccgatgaccc ccatagctac
     6181 acgttttttt gtgataacca aaccattttc aagctgactt gtttctaaaa cttcaccgat
     6241 tggatctggt aaggcaacca cttcacgaat tcctcttgcc atcgcttcta tacgatctgc
     6301 atccaaataa agacgatcca acatcacatc tgagattttc cccttagccg ctgccatatc
     6361 gagggcatta gccgctaaaa tttcctcagt agcagccact aagtgatcag ccatggctag
     6421 caagacttgg tttttcactt cttcactagc tgtgttaatc gattttttaa cagcctgtac
     6481 ctgttcaaat tgttcttgtc tactcaccat agtttacctc taaaattctg taaaaagtag
     6541 ttggatttca ggagtaatgg aaatccagtc gtcacggtaa atcaagacac ccttggcttt
     6601 ttgagaacgc aacatatcct ccaaagcaga tgctccaaat tgcacgcgtc cttttccaag
     6661 tgattttcca ctttccttgt caaatactgt cacgatatca ccgtaagaaa agactccttc
     6721 tgcttcaacg ataccagata agagaagact ctttccatgt tgagagagag cttccgcagc
     6781 ccctttatca acccaaatag aaccttgact ctgagcatag aaggcaagcc attgtttctg
     6841 ggtacgaagc cccttctctt gagcaacaaa gtaagaacca tcctcggtct cctctgccgc
     6901 ctcaatcatg gaatctgatt tcaaggatga gcagatataa acaggaactc ctgattccgt
     6961 cgcgatagtt gcagccttga ttttggttaa cataccccca gttccgtttg acgaaccagc
     7021 tccaccagcc atatcaataa tctcacgatt gatggtctcg attctctcca agcgtttggc
     7081 tcttggatct gaattaggat ttccagtata gagaccgtcc acatctgtca agagaaccaa
     7141 aaggtctgct tggaccatcg ccgctacttg ggcacttaga gtgtcattgt ccccaacctt
     7201 gacctcatca ataacgacac tatcattctc attgatgata ggaattgccc cacggttgag
     7261 caaaaccgac aaagcctgat gggcattttt ataacgacgc ttatccacaa agtcatcttg
     7321 ggtcagcaag atttgtgcag aaacgatttg acgcaagaga agattggttg tatattcttc
     7381 caacaaaagc ccctgcccta ccgctgctga agcctgttta tcagcaattt tagtcggacg
     7441 ctttttaaat cctaaggctc caaaaccagc cgcaatggca cctgaagaca ccaaaatcaa
     7501 ctcatgacca gcctcgtgca gcatagccaa ctgctgggta atatccttta ccttactacg
     7561 tgataaactt ccatcctcat ttgtcagaga agaagtaccc accttaaaga caatccgttt
     7621 gtatttcata gtctcactcc gattattcat atttatccat tataacatga ataacaggaa
     7681 atagaaaaga gttgatagga aaaagaaggc cctaaaacct tcttttctac tactgttctg
     7741 attccgattt gtttacactc gtttcagagc tttgtgaagt tgaggatgtc aaatcttgac
     7801 tagttgaaga atttgtaaca ctttcatgtt gactcgtttc tttattttca agatcctttt
     7861 tcactacttc tttggattct tttatttctg aatgacttgt agttttaatt gtagcagatt
     7921 tctcgatcgg aacatccact aaccaggcac cacttgaatc cacagtatag ccttctggtg
     7981 tcttaccatt cacaagtaat tgaccatttt ctttcaagaa gtaccattta tccttgtctt
     8041 taatccaacc tatagctcgt gaaccatctg tcttgtagaa ataccaatca tttgcctttt
     8101 taagccagcc ttgcttcata gctcctgatt cttctagata gtaatgatgt ccagcaactt
     8161 ctatctcacc tgtcttcatg ataccagtag aatccatata gtaccaggct tctttatctt
     8221 ttacccagcc cgttttcatt tcccctgatg gagcaaagta ataccattgc cccttatatt
     8281 gaagccaacc tgtcttcata gagccatcaa catccaaata ataccactgc tctttatctt
     8341 gaatccaacc aatttccatc tggttttctt tgttaaaata ataccagatt ccagcgattt
     8401 tcttccaatt tttagcagca acaccagagt ctgtcaaata gaaccaacga ttgttccatt
     8461 ttttccattg attctgtaat aagatacccg tttggttaaa gtaataccat tcacccttaa
     8521 tttcattcca accgacaaca tactctcctg tagaatcagg cgcttgatac caccagtttc
     8581 catatgaact cttatgccaa ccagcttgaa aacttggaat aggcttgtag gatgttgaaa
     8641 tattgacaaa accgtctttt cgaatatcaa aaactgttgc atcatagtct ttgctggctg
     8701 cgttgattct ctcaattcct cgttctttga gccaattaac atactcacta tcaacaccat
     8761 ttttccaagg tagactatcc gaagtttgaa caatcaaact cggactcaaa tttttaatga
     8821 aatccttggt atttgatttg ttggtatcat ggtgatgatt aaacttcatc aaatcaactt
     8881 ttccaatgag aggaccatac ttgtcttctg ctccatgaac attatctaaa tcgcccccaa
     8941 ggtaaatttt cttgccattg actttcacca cgctaatcaa ggaattggaa ttgtcatccc
     9001 aaattttctt taattcaccc gatgaatcag tttcattttc ataattatag agctgaatat
     9061 ccatgtcccc aaactgaaaa tgagcatccc cttgtgtgat attttgaata actgaaacac
     9121 ctttttctgc agcagtctgt aaaaccttat catagccata cagattatcc catagacgtt
     9181 cagaattagt aatacgacta tcactatatt tcttaagata gactcggtca actggatagg
     9241 tagacagtaa ttcatcaaca tttccaatat gatcactgtg ggtatgggtc accaaaataa
     9301 aatcaagttt ttggacaccc aattccttca aacgacgaaa gacacggtct gttagaacat
     9361 gcttataaga cgtttcaatt ccttctctcc atggatagcg agaatcacta ccgtctggga
     9421 agtcataatc ttctcctgta tccaccatgg caaaatgtcc attgctttca agaataatcg
     9481 catcactgcc accttcttga acattgataa agtggatttt atttcctgaa ctttcttgag
     9541 cctgaacatt cccataccat gacaaaccta aaaaagcgcc tacaagtgct aaactagtta
     9601 atttcttttt cattcttact ttctcaatct ctccaaggtt tccttaaaaa tctctgggat
     9661 atctgcttta aattccaagg tcttacctgt tctcggatga gtaaaaccta aagtcttggc
     9721 atgaagaaat tgtccatgtc ctttcaaagt cttgcgagga ccatagacct catcaccagc
     9781 gactggatgg ccgatataag ccatgtggac acggatttga tgagtgcgcc ctgtctccag
     9841 ttgcaactct actaagctat aatcgccaaa gcgttccaag acgtgaaaac gcgtcactgc
     9901 aggcttccct ttagcagtca cagcctgttt cttacggtct ttttcactcc ggccaatcgg
     9961 cgcttcaatt acaccacgat cattaggcag atttccatga acaatcgccc aatatttgcg
    10021 gagagacttt ttatccttga gttcttgggc aagtgctaga tgcgcatcat cgtttttagc
    10081 aatcatgaga agacctgacg tatccttatc aatacggtga acaatccctg gacgcagaac
    10141 cccattgata cccgacaagt ccttaatatg atacatgagg gcatttacta gggttccact
    10201 ggtatgacca gcactcgggt gcacaaccat tccctgaggt ttgttaacga cagccacatc
    10261 ctcatcttgg tagactattt ctagcggaag atcctcagcc acatactcta atacctctgg
    10321 ttctggcaca tggtaagtga cgacatcacc ctcttggact gtgtatttag ctttcttgac
    10381 ttgaccattg accaaaacct ggcctgattt aatttgttca ttcgcgagac tacgtgataa
    10441 ttctgacaaa tctgacaaag ccttatccaa acgcagacca ccagtttcaa ttttaatttc
    10501 catttatttc ctcttttagc attgcaatca ataaaataat cactccaacc gtcagatagc
    10561 tatctgccac attgaaaatt gcaaagttga taaagtcaag gtggaacata tccacaacaa
    10621 agccctgact gaccctgtca ataaagtttc caagaccacc cgcgattatt agagtcaaac
    10681 ccaagaccat ccagaatgag tcctccatgt gtttatgtaa ataccaaatg gcacctatca
    10741 cgacaaccag agtaatgaca gcgaataaca gctgctgatc ttgtaagata gaaaaggctg
    10801 cacctcgatt ttgcaggtag gtcaagctaa cgaaattggg aatccaggag cgcacttcac
    10861 ccagtggaat ctgctggacg atataggatt tgaccaactg atccagccca attaaaagca
    10921 gtacaatgac tgccactatt gctctttttt tcatgatttc ctcttttgat caaaatattc
    10981 ttgcatgact tctacgaaga gagtcccagc ttgactaagc tccacttctt cacgtttaac
    11041 atagaccatg cggttatcta ggttatcctt gagacgaata actgtaatgc cattaacact
    11101 gtcactatct aaaaatccag aacctgtcgc ataggcgtcc gtccgctcca aaataccatt
    11161 caaggtggca cggtctgtca cattaaacat ctgtgagcta gcgctggtat cgacaaagtt
    11221 ctctgaataa taaaggtact cgtctttctc ttgagtgaaa cgaaccgttg gtaaatccgc
    11281 taaatcctcc atgactaatt cctctttccg agctaaagga tgaccctcac agagataaat
    11341 atgggtatgg aaaggaatca attcgatgac ctccagacct aacttttcaa cccgttgcat
    11401 aatccccttt ttattttgat tgttgaggta gataatccca atctcactat gcccttgcgc
    11461 cacttcatct aatatttgaa cagtagttga ttcaaaaata cggaagttct tatagtcagg
    11521 atagcgctct gaaaaggccg taatagttgg tggtaagaag tcatagtgct ggctagcaac
    11581 ggaaaattca tctttttctt cttcaggatt ggcatactga ttttgaaaaa tatcaaatcc
    11641 tttaaccaat tcttgcgctt tttcataaaa ttccatccca cgacgggtca agaaagtccc
    11701 tgagctggtc cgacggaaaa tcttaaagcc caactctttt tccaaatcac gaacagaaat
    11761 agacagactc ggctgactaa catacatctt ttcagcagct tcacgaaaag taccactatt
    11821 ggcaatagcc acaacatagc gtaattgttg aatgttcatc ttctaccccc aacttcttta
    11881 tctttttatt ataccatatt ttagaagttt tccaaaaagg aaaaaagaac atcctattct
    11941 tcttaactat cttcactatc tgcctttctc acgccaatct tattttcaaa atcaattcaa
    12001 aaaaataagt ggctacacac cacttcagta tcggaaagaa aaacgttgac tatttgtgaa
    12061 aaaagaaaat gccggaaaat tccgacattt tttagtaagc taacttcctg aaaataggag
    12121 taaccaaaca tcccagaaag cagtgatatt gatgagaata tgaactagta ttggatagta
    12181 gatgttttta gtcatgcgat acaatagagc caaaataaga cctccgctag cataaatgaa
    12241 aaaagcaaga ggagttaaag caaaattgat atgaatataa ccgaaaataa tagcagaaag
    12301 caagacatct ccgtaccaag gcgagttttt gaaaaaggtt gtcataagca caccgcgata
    12361 aatcaattcc tcagcaatag ggccgatgaa gcaaacgatg agcaaaaaat agggtaattc
    12421 ctgtctccct atcatttcta tcgtttcatt caaagaaatt tgatttgaag acagggatat
    12481 gaaatacgaa aagagaaagt cagacatata cgaagtgatg taacccagta aaaggtagat
    12541 aaaatacctc agctgccact tgaaatgaaa agttttcttt cctgcaaaaa ctagtagata
    12601 gatgaccgct aataaaagaa ctccactctc catcaaaagc agaatctgaa aaaattcacg
    12661 acttgctggt agatagggct ttgcgagata attgaaaagc ctccaaaacc aagttgattt
    12721 gtaaaaaatt aaggacaatg ctagtaaaat ttgaatagcc cgttttttca tattaaattc
    12781 tctgctttct ccacttgttt cttcatatta ctaataaatt ttacttaaaa tctcgcagca
    12841 cttcctttgc aaagatgatt acctcctcca atatatccta aatcatcggt gtctctggga
    12901 caaaatccat gaaccagcag agttaatact ggttccattt tccaaggata ataaccatta
    12961 ggttctttac catagggatc tgctccacct tgtatcagct ctaattcttc atttgttaga
    13021 tttatatttt ttgtcattaa aatcatgata tatttcctcc gttattgttt agattagttg
    13081 agtaatctgc tactcatacc tacttacaaa aaaactatta tattaagttg gttttttaat
    13141 ttgtctagtt gcaacattga caaacatagt atagcatatc tttgccaaat atcctcttca
    13201 aatcatgaat tgtcatcaaa acatcttaaa ctataaaatc aattagtctc aagctttcta
    13261 tcaatttctt atccaaaata tgctataata ataccaaaag ataaagaagg aagacctatg
    13321 attaaactac tagccttgga tatggacggc accctcctca atgaagccaa ggaaatccca
    13381 caagctcaca ttactgctat tcacaaagcc attgaaaaag gtgtcaaact ggttctctgt
    13441 acgggtcgcc cccttttcgg tgtcctcccc tactacaaaa aactggggct tgacctccag
    13501 aacgaatatg ttattgttaa caacggttgt tcaactcacc aaaccagtga ttggggtcta
    13561 gttgactgga aagaactgag tccagctgac atcgaatacc tctatgacct tgctgaaaag
    13621 agtgatgttc agttgacact ttttgacgag tcacattatt ttgttctcgg tggcaagccc
    13681 aatcaagtta ttgaaaatga tgctaaacta gtattttcag acctgactga aatttctctt
    13741 gaggaagcga ctagtggaaa gttccggatg ttccaaggta tgtttttagg aacaaaagaa
    13801 caaacagacg attttgagca gcgttttgct gaagagcttt gccaacgatt cagtggagtt
    13861 cgttcgcagc ctgtcattta tgaagcaatg ccacttggaa cgacaaaggc tactgctctt
    13921 tcacgactag ctgagatttt gaagattgat tcctcagaga ttatggccat gggcgatgct
    13981 aataacgata tcgaaatgct ccagtttgca gggcttggga ttgcaatggg aaatgccagc
    14041 gattatgtca aatctcttgc ggatgccgtt acctcaagca acgaagaaga cggcgttgcg
    14101 cgtgctattg agaaatatat tctataaaaa agaaaagcaa atagacagaa gttactgcta
    14161 tttgcttttt tgctaatatt ttaaaatacg gactaatcaa tagacaagaa tagcgaatca
    14221 taaaaatcga tttactagat gccatagtat cttatagttg ctaataagaa gttagtctag
    14281 cagaatgaat ctctcatttc tcccacacta atctgtaatt tgtctataca tttctggtct
    14341 tctatctcga aacaagcccc agtttagacg ttcacttgct cccttgtcta ggtcataagt
    14401 agctaacaga acagcttctt cttgtctttc agctcgttct agaatagctc ctgtttcatc
    14461 cgtcataaag gaggaaccgt agaagtcaag actggaactc tgtccgccat tttcctcact
    14521 aggagtaacc tcctctaaac cataacgatt ggctgcgatg actggaacaa tattcgctgc
    14581 tgcgtgccct tgcatagtac gttgccagtg accacaacta tctgtatcca aaattggctc
    14641 tgaaccgata gctgtaggat aaaagagcaa ttcagcacca ttcaatgcaa gacagcgcgc
    14701 tgtttcaggg aaccattgat cccaacagat accgatacca atcttagcat agcgagtatt
    14761 ccagaccttg aaaccagtgt taccaggcgt gaaatagaat ttttcttgat aataatggtc
    14821 atctggtata tgggtctttc gataaacgcc cagcacttcc ccatctgcat caatgacggc
    14881 aatagagtta tacaagacat taccatcttt ttcatagaaa ctgattggta aaacaacttg
    14941 tagttcctta gcaatcacct taaaatgctg aatggcagta ttttccgcta cagattgggc
    15001 atactggtag tagtcatact gacgttcctg acagaaatag ggatgttcaa acaactcggg
    15061 caagagaata atttgggctc cttgctcagc agcctgacgt actaaacgct ctgcggtttg
    15121 gatatttgtt gccacatcct tagcgcattg catctgaatg gttgcaactc ttacatttct
    15181 catctttttc tcctattctg gaatttgttg ggtgatacag tggatattgc caccacctaa
    15241 gagaatatct ctggctggta ttccgacaac tttacggtct gggaaacact tgctgaggat
    15301 atctaaggcc acttggtcgt ttacatcctc aaactgtgga accaagacag ccttgttggc
    15361 gatataaaag tttacgtagg aagctgctag tcgttcacct gcgtatcgct cttcttctcc
    15421 ttcttcatag atgtagcctg gcaaatcttc ttctgtcaca acttgtcgaa ctgcagggat
    15481 aggcaattta tgaatggtga agtgacaacc ttttgcatct gtttcctgtt ctaagagttc
    15541 gagatctgct tttgacatgg catactgggg atcattttcg tcatctgtcc aagccaaaac
    15601 aacctcagca ggaccaacaa aggcagcaac attatcgacg tgttcattgg tttcatcctg
    15661 ataaatacca taaggaagcc aaataacttt ttcagcacca agactttcta ataatgtgtt
    15721 ttcaatctcc tctttagtca agttaggatt gcgaccagga ctaagcaagc aactttcagt
    15781 tacgagaata gttccttgac catcgctatg gattgcgcct ccttccagta caaaaggttt
    15841 agcatcatag acaggccttt ccaaggcctc agcaaaacga ctggctactt ggtcatcctc
    15901 ttcataatct tgataaagac catcataggt gcctccccaa gcattgaagg cccaatccac
    15961 ggctaatttc ttacctttgt cattgacgag aatggttggg ccagtatcac gcgcccaggc
    16021 atcattggtg ggaatgtcta aataaacaac cttgtctcca agataggatt gggcttcaga
    16081 tagataggcc tgctccacca aaagatagac tctttcccct tctgctatag tctcgatgat
    16141 ctgagtaaat gctcttttag catcctttcc ttgaaaaggc catgatcctg gtcgagtcgg
    16201 ccatatcatg agggtaccat gatggggttc gtactctgct ggcatgtgat agcctaattt
    16261 ttttggactg tccatcatga taatctccct ttaaagtctt gatagccaaa agctttgagt
    16321 aagctacagt ctccctgttc gtccatgaga tagagacttg gcaatccaat accattaaag
    16381 gtattatttt tgacaaaaga ataaatggcc atgtcttgaa aataaagtct gtctccgatt
    16441 tggactggat tttcaaaact ataatcacca atcacatcgc ccgtcagaca ggtattagaa
    16501 gaaagtctgt aggtatgggc tttttcctgt gcctcaaagc catttctcaa aggtggacga
    16561 tagggcatct caagtacatc aggcatatgg caggtcgcag aggcgtctaa aaccaagatt
    16621 tccataccgt tttctacaat atctaatacc tcagttgcta aataacccgc attaagcgca
    16681 atggcttcac caggctcgat atagatttca agattgtaag tttttcggat acgcttgatt
    16741 tctgaaatca gcaaatccac atcgtaacct tctcttgtaa tatgatgacc accacccata
    16801 ttgagccatt ttacctcatg taagtaggga ccaaactgtt cttctactgc tttcaaagtt
    16861 gtttgtaaat catctgctcc ctgctcgcaa agggtatgaa aatgaagtcc gtcaaccaaa
    16921 tctagcaaat cactcggaat cttgtctata gtaactccaa agcgagaacc tggtgcacaa
    16981 gggtcataga gcgcgtgatc tccttgagtt gaacactgag ggttgaggcg caaaccaaca
    17041 ctgacaccag cctctcgaca acgcgaacca tgcttacgca actgtctctc tgagttaaag
    17101 acgatatggt ctgttatccc aagcaattcc tccatgtcct catccttgaa agctggtgca
    17161 aaaacatgga cttcaccagg aaattcttcc cttgccaatt tggcctcata gagtccacta
    17221 gctgtcgtac ctgatagata ctggctaatc aagggataag ttttgtagag ggaatatgcc
    17281 ttctgggcaa gcaagacctt gcaaccggcc tcttcttgta catattgtag aatgcggcaa
    17341 ttagcttcta acttggccaa gtcaataaca taggctggtg ttggtacttg ttctaacttc
    17401 attagtccac catttgtgga ttttcaacca caacccatgg caaaccatac tcattcaaag
    17461 cttccatgaa tggatctgga tctaactcct caaggttata cactccagct tgtttccaag
    17521 ttccgttcat gactaatttt gtcccaatca tggctggaac tcctgtcgta taagaaatag
    17581 cttgcgaacc aacctctgcg taacattcct gatggtcgca gacattgtag atatagatag
    17641 tctttttgac accgtctttg acacctgtaa agatacatcc aatattggtt ttacctacag
    17701 tacgtggacc aaggctagca ggatctggaa gcaaggcttt caaaaattga attggaacaa
    17761 tttcttggcc gttaaagtta atggtatccg tacgaaggag tccaacattt tcaagacatt
    17821 tcatgtgcgt caagtaagat tgaccaaaag tcataaagaa acgaatgcgt ttgacacctg
    17881 gaatgttctt ggccaatgat tcgatttctt catggtgaag gagatacata tctttttgtc
    17941 caacttgagg gaaatcatac tcacgcttga tagacatagc ttcgacttcg acccatttcc
    18001 catcttccca gtaagaacct ggcgcagaaa cctcacggag attaatttct ggattaaagt
    18061 tggttgcaaa tggataaccg tggtcaccgc cattacagtc taaaatgtcg atataatgga
    18121 tttcatcaaa atagtgtttg agggcataag ctgaaaagac actagttaca cctgggtcaa
    18181 aaccagaacc aagaagagca gtcaagcctg cttctttgaa tttctcttga taagcccact
    18241 gccatgagta gtcaaagtag gctgtaaaac caagttcctt acaacgtttt tcgtagatag
    18301 cacgccactc agggtcttct gtgtcttctg cttcgtagtt ggctgtatcg atatagtgaa
    18361 cacctgttgc caaacaagca tccataatgg ttaaatcttg ataaggcaga gctacattca
    18421 aaacagcttc tggtttgtag ctttcaatca gagcaatcac ttcttcaacc ttgtcagcat
    18481 caagagcagc tgtctcaatc tttgtacttg ttttgccttc cagtttagct ttcaagtcat
    18541 cgcattttga cttggtacgg ctagcaatca taatctctgt aaatgtttcg ctatcttgac
    18601 aaatctttga aatagcaact tgggcaacgc ccccacaacc aataactagt aaacgactca
    18661 tttttttcct tcctcttctt ctaaaatgtc ctcaacatac ttgggcaaca taaaggctcc
    18721 cacgtgtaag tttgcagtgt agtattctgt gaaaagctgg cgttttttcc agccttcctt
    18781 gtcaaaatct ttgacagggt ggtatttttt cgatgcaaat ccaaacaacc aatagccagc
    18841 tgggctagtt ggaatatggg cctgataaac ccgactgatt ggaaaggctt gattgacctt
    18901 gcggtgcatg cttcggcagg ccgactcatc ctcgtcaaag aacggactcc catgctggta
    18961 aatcatgatg ccgtcttcct tcagagctcg ataactattg ccgtagaatt ccttggtaaa
    19021 gagtccttcc gtatggccaa atggatctgt cgcatcgttg atgataatat catagtcata
    19081 ttcgcagttt cgcaaaaagc gtagcccatt ttggtagtaa atggtaacac gaggatcatc
    19141 taggcctgca gcaaagtctg ggaaatactc acgacagacc tcgaccaaca tctcatccgg
    19201 ttccacgata tcgatttgtt ccagttcagg atagagtgtt aatacttggg caacaccgcc
    19261 gtcaccaccc ccaataacca atactttctt tggatttggg tggacagcca tgggaacgtg
    19321 aacggtcatt tcattgtaga cgaaatcatc cgcatctgag aacaagacat ggccatttaa
    19381 aatcagtatt ttcccaaaag ctggcgtatc caagacttcg atatcctgcc attcactttt
    19441 tccagcgtaa agttgcttgg ctgttctcag agacaatttg acatctggag tatgaacttc
    19501 agaaaaccat aaatccatct atttctcc
//
LOCUS       DBERMM010000037        19089 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.037, whole genome shotgun sequence.
ACCESSION   DBERMM010000037 DBERMM010000000
VERSION     DBERMM010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 19089)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19089)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19089
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.037"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..342
                     /locus_tag="ACL8AS_001602"
     CDS             <1..342
                     /locus_tag="ACL8AS_001602"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine motif-containing protein"
                     /protein_id="HGS1229431.1"
                     /translation="KPNEEKPQTEKPEEETPREEKPQSEKPESPKPTDEPEEESPEES
                     EEPQVETEKVEEKLREAEDLLGKIQDPIIKSNAKETLTGLKNNLLFGTQDNNTIMAEA
                     EKLLALLKESK"
     gene            690..764
                     /locus_tag="ACL8AS_001603"
                     /pseudo
     CDS             690..764
                     /locus_tag="ACL8AS_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397816.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxyacetone kinase subunit L"
     gene            764..982
                     /locus_tag="ACL8AS_001604"
                     /pseudo
     CDS             764..982
                     /locus_tag="ACL8AS_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443785.1"
                     /note="phosphoenolpyruvate-dependent sugar
                     phosphotransferase system; catalyzes the phosphorylation
                     of incoming sugar substrates concomitant with their
                     translocation across the cell membrane; IIB is
                     phosphorylated by IIA and then transfers the phosphoryl
                     group to the sugar; IIC forms the translocation channel;
                     incomplete; partial in the middle of a contig; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose family transporter subunit IIA"
     gene            1391..2104
                     /locus_tag="ACL8AS_001605"
     CDS             1391..2104
                     /locus_tag="ACL8AS_001605"
                     /EC_number="3.1.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008253 - 5'-nucleotidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HGS1229432.1"
                     /translation="MFYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYY
                     VPMNKALWKDLELKKISKQELVNTRFSRLFAHFGQEKDGSFLAQRYQFYLAQQGQTLS
                     GAHDLLDSLIERDYNLYAATNGITAIQTGRLAQSGLAPYFNQVFISEQLQTQKPDALF
                     YEKIGQQIAGFSKEKTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVY
                     SYQDLLDCLDKNILEKITF"
     gene            2162..2764
                     /locus_tag="ACL8AS_001606"
     CDS             2162..2764
                     /locus_tag="ACL8AS_001606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229433.1"
                     /translation="MSEVDFNEAVNYEFTSDTCQLANSIYQSLFKFFDKKNFSGDLIF
                     TWKSPSLVKERDYIGRRDSQVDNLRVIGNIFLNYLTNRKYSLNMNRNGCMGDFPHDFF
                     DIYLDHVAKYAYEQKVNNIKEYYPLKRAILHQENALYFRFFSNFDDFLEKNYLKTIWQ
                     VSKETPFSEMDFNMFKNISEKIIFERGSKMLNDLKSNYKK"
     gene            2900..3553
                     /locus_tag="ACL8AS_001607"
     CDS             2900..3553
                     /locus_tag="ACL8AS_001607"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA];
                     GO_process: GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HGS1229434.1"
                     /translation="MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQ
                     ALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKK
                     SHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
                     AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANTFLKETGQEPIDWLR"
     gene            3563..4027
                     /locus_tag="ACL8AS_001608"
     CDS             3563..4027
                     /locus_tag="ACL8AS_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003012002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX domain-containing protein"
                     /protein_id="HGS1229435.1"
                     /translation="MPQLATICYIDNGKELLMLHRNKKPNDIHEGKWIGVGGKLERGE
                     TPQECAVREILEETGLKAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGT
                     LEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE"
     gene            4040..5308
                     /locus_tag="ACL8AS_001609"
     CDS             4040..5308
                     /locus_tag="ACL8AS_001609"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004151 - dihydroorotase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HGS1229436.1"
                     /translation="MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETI
                     NATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVE
                     TLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
                     KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMI
                     AYATKAHVHIQHLSKEESVKVVEFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMN
                     PPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLS
                     LTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRFVDSHFA
                     SKAANSPFIGETLKGQVKYTICKGQIVYQA"
     gene            5322..5582
                     /locus_tag="ACL8AS_001610"
     CDS             5322..5582
                     /locus_tag="ACL8AS_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229437.1"
                     /translation="MNYFRKRRERQAKSNSGIYCPAANRSKIQYETKEKADHAVQYDN
                     GGLVRSYYCRTCACWHTTSKSNKPPLSLKNYGLKLFGLDKSE"
     gene            5593..6954
                     /gene="pdrM"
                     /locus_tag="ACL8AS_001611"
     CDS             5593..6954
                     /gene="pdrM"
                     /locus_tag="ACL8AS_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-coupled multidrug efflux MATE transporter
                     PdrM"
                     /protein_id="HGS1229438.1"
                     /translation="MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNT
                     MDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLS
                     VVLLGMVLFLAPIILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLT
                     KLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQ
                     EKLKALHLEKRIPLNMDKIKEGVRLGLPIGGTVFAEVAIFSVVGLIMAKFSPLIIASH
                     QSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTF
                     LYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYL
                     GLLGYWGVAIPVATLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAK
                     SKC"
     gene            7108..8076
                     /locus_tag="ACL8AS_001612"
     CDS             7108..8076
                     /locus_tag="ACL8AS_001612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HGS1229439.1"
                     /translation="MSTLDKNLLLEMFRKMEEIRRMDLKIAQLVKKGKVPGMTHFSVG
                     EEAANVGAMLALNPDDLITSNHRGHGQAIAKGIDLNGMMAEILGKYTGTCKGKGGSMH
                     IADLDAGNLGANGIVGGGMGIAVGAALSQQMQNTGKIVVCFFGDGATNEGVFHEAVNM
                     ASIWNLPVIFYCINNGYGISADIKKMTNIEHIHQRSAAYGIPGMFIEDGNNVIDVYEG
                     FQKAVDHVRSGNGPVLIESVTYRWLGHSSSDPGKYRTREEVELWKQKDPIENLRNYLI
                     ENNIASAEELEEIQAQVKEAVEASVKFAEESPFPPLESAFEDIYAD"
     gene            8092..9084
                     /locus_tag="ACL8AS_001613"
     CDS             8092..9084
                     /locus_tag="ACL8AS_001613"
                     /EC_number="1.2.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000448722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HGS1229440.1"
                     /translation="METKTMSFRDTIILAMSEEMRRDENVFLMGEDVGVFGGDFGTSV
                     GMLEEFGPERVRDCPISEAAISGAAAGAAMTGLRPIVDMTFMDFSVIAMDNIVNQAAK
                     TRYMFGGKGQVPMTVRCAAGNGVGSAAQHSQSLESWFTHIPGLKVVAPGTPADMKGLL
                     KSSIRDNNPVIILEYKSEFNQKGEVPVDPDYTIPLGVGEIKRQGTDVTVVTYGKMLRR
                     VVQAAEELAEEGISVEIVDPRTLVPLDKDIIINSVKKTGKVVLVNDAHKTSGYIGEIS
                     AIISESEAFDYLDAPIRRCAGEDVPMPYAQNLENAMIPTVESIKDAIRKTYNKE"
     gene            9302..10345
                     /locus_tag="ACL8AS_001614"
     CDS             9302..10345
                     /locus_tag="ACL8AS_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045254 - pyruvate dehydrogenase complex
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006086 - acetyl-CoA biosynthetic process
                     from pyruvate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /protein_id="HGS1229441.1"
                     /translation="MADDKLRATPAARKLADDLGINLYDVSGSGANGRVHKEDVETYK
                     DTNVVRISPLAKRIALEHNIAWQEIQGTGHRGKIMKKDVLALLPENIENDSIKSPAQI
                     EKVEEVPDNVTPYGKIERIPMTPMRKVIAQRMVESYLTAPTFTLNYEVDMTEMLALRK
                     KVLEPIMEATGKKTTVTDLLSLAVVKTLMKHPYINASLTEDGKTIITHNYVNLAMAVG
                     MDNGLMTPVVYNAEKMSLSELVVAFKDVIGRTLDGKLAPSELQNSTFTISNLGMFGVQ
                     SFGPIINQPNSAILGVSSTIEKPVVVNGEIVIRPIMSLGLTIDHRVVDGMAGAKFMKD
                     LKELIETPISMLI"
     gene            10391..12094
                     /gene="lpdA"
                     /locus_tag="ACL8AS_001615"
     CDS             10391..12094
                     /gene="lpdA"
                     /locus_tag="ACL8AS_001615"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003001382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004148 - dihydrolipoyl dehydrogenase
                     activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HGS1229442.1"
                     /translation="MALEVIMPKAGVDMTEGQIVQWNKKVGEFVKEGEILLEIMTDKV
                     SMELEAEEDGYLIAILKGDGETVPVTEVIGYLGEERENIPTAGAASPEASPVPVASTS
                     NDDGKSDDAFDIVVIGGGPTGYVAAIKAAQLGGKVALVEKSELGGTCLNRGCIPTKTY
                     LHNAEIIENIGHAANRGIVIENPNFTVDMEKLLETKSKVVNTLVGGVAGLLRSYGVTV
                     HKGIGTITKDKNVLVNGSELLETKKIILAGGSKVSKINVPGMESPLVMTSDDILEMNE
                     VPESLVIIGGGVVGIELGQAFMTFGSKVTVIEMMDRIVPAMDAEVSKNLRLILERKGM
                     TILTGTKLQEIIEENGQLRIKVEGKDDIIASKALLSIGRMPDLEGIGEVEFELDRDCI
                     KVNEYMETSVPGIYAPGDINGTKMLAHAAFRMGEVSAENALKGNHAVAKLNLTPAAIY
                     TLPEVAAVGLTEEQAREKYDVAIGKFNFAANGRAIASDAAQGFVKVIADKKYGEILGV
                     HIIGPAAAELINEASSIIEMEITVEEMLKTIHGHPTYSEVMYEAFADVLGMAIHSPKK
                     K"
     gene            12158..13147
                     /locus_tag="ACL8AS_001616"
     CDS             12158..13147
                     /locus_tag="ACL8AS_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HGS1229443.1"
                     /translation="MKYIINHSNDTAFNIALEEYAFKHLLDEDQIFLLWINKPSIIVG
                     RHQNTIEEINRDYVRENGIEVVRRISGGGAVYHDLNNLNYTIISKEDENKAFDFKSFS
                     TPVINTLAQLGVKAEFTGRNDLEIDGKKFCGNAQAYINGRIMHHGCLLFDVDLSVLAN
                     ALKVSKDKFESKGVKSVRARVTNIINELPKKITVEKFRDLLLEYMKKEYPEMTEYVFS
                     EEELAEINHIKDTKFGTWDWNYGKSPEFNVRRGTKFTSGKVEVFANVTESKIQDIKIY
                     GDFFGIEDVAAVEDVLRGVKYEREDVLKALKTIDITRYFAGISREEIAEAVVG"
     gene            complement(13214..14284)
                     /gene="xerS"
                     /locus_tag="ACL8AS_001617"
     CDS             complement(13214..14284)
                     /gene="xerS"
                     /locus_tag="ACL8AS_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000817875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine recombinase XerS"
                     /protein_id="HGS1229444.1"
                     /translation="MKREILLERIDKLKQLMPWYVLEYYQSKLAVPYSFTTLYEYLKE
                     YDRFFSWVLESGISNADKISDIPLSVLENMSKKDMESFILYLRERPLLNANTTKQGVS
                     QTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLAARAENIKQK
                     LFLGDETEGFLTYIDQEHPQQLSNRALSSFNKNKERDLAIIALLLASGVRLSEAVNLD
                     LRDLNLKMMVIDVTRKGGKRDSVNVAAFAKPYLENYLAIRNQRYKTEKTDTALFLTLY
                     RGVPNRIDASSVEKMVAKYSEDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHAS
                     TQVTDLYTHIVNDEQKNALDSL"
     gene            complement(14868..16418)
                     /locus_tag="ACL8AS_001618"
     CDS             complement(14868..16418)
                     /locus_tag="ACL8AS_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA];
                     GO_process: GO:0006821 - chloride transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HGS1229445.1"
                     /translation="MEEQSEIVRSKKEFAFASSTILSQVGRGIIVGLIVGIIVGSFRF
                     LIEKGFHMIQGVYQDQGYLVRNLFVLVLFYILICWLSAKLTRSEKDIKGSGIPQVEAE
                     LKGLMSLNWWGILWKKYVLGILAIASGLMLGREGPSIQLGAVGGKGIAKWLKSSPVEE
                     RSLIASGAAAGLAAAFNAPIAALLFVVEEVYHHFSRFFWVSTLAASIVANFVSLLMFG
                     LTPVLDMPDNIPPMTLDQYWIYLVMGIFLGFSGFLYEKAVLNVGRVYDLIGQKIHLDR
                     AYYPILAFILIIPVGIFLPQIIGGGNQLVLSLTEQNFSFQVLLAYFLIRFIWSMISYG
                     SGLPGGIFLPILALGSLLGALIGVICVNLRLVSQEQFPIFVILGMSGYFGAISKAPLT
                     AMILVTEMVGDIRNLMPLGLVTLVSYIIMDLLKGTPVYEAMLEKMLPEEVSSEGEVTL
                     IEIPVSDKIAGKQVHELNLPHNVLITTQVHNGKSQTVNGSTRMYLGDMIHLVIPKSEI
                     GKVKDLLL"
     gene            complement(16434..17213)
                     /locus_tag="ACL8AS_001619"
     CDS             complement(16434..17213)
                     /locus_tag="ACL8AS_001619"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HGS1229446.1"
                     /translation="MATIKEIKELLVTVKELESPIFLELEKDNRSGVQKEISKRKRAI
                     QAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKG
                     LNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSP
                     QPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDF
                     ATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES"
     gene            complement(17200..18051)
                     /gene="ylqF"
                     /locus_tag="ACL8AS_001620"
     CDS             complement(17200..18051)
                     /gene="ylqF"
                     /locus_tag="ACL8AS_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HGS1229447.1"
                     /translation="MATIQWFPGHMSKARRQVQENLKFVDFVTILVDARLPLSSQNPM
                     LTKIVGDKPKLLILNKADLADPAMTKEWRQYFESQGIQTLAINSKEQVTVKVVTDAAK
                     KLMADKIARQKERGIQIETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQ
                     WLKTNKDLEILDTPGILWPKFEDETVALKLALTGAIKDQLLPMDEVTIFGINYFKEHY
                     PEKLAERFKQMKIEEEPSVIIMDMTRALGFRDDYDRFYSLFVKEVRDGKLGNYTLDTL
                     EDLDGND"
     gene            complement(18466..>19089)
                     /locus_tag="ACL8AS_001621"
     CDS             complement(18466..>19089)
                     /locus_tag="ACL8AS_001621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element ISSpn5 family transposase"
                     /protein_id="HGS1229448.1"
                     /translation="KLKKNTVLSCLGDLSLPCPQDEDLTILPHSAYSETLYQAGSWSH
                     KRRVCQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIKEMKEGFFGD
                     KMDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLHVVGKCVRTG
                     RKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMH"
BASE COUNT         5779 a         3566 c         4049 g         5695 t
ORIGIN      
        1 aaaccaaacg aggagaaacc tcagacagaa aaacctgagg aagaaacccc tcgagaagag
       61 aaaccgcaaa gcgagaaacc agagtctcca aaaccaacag acgaaccaga agaagaatca
      121 ccagaggaat cagaagaacc tcaggtcgag actgaaaagg ttgaagaaaa actgagagag
      181 gctgaagatt tacttggaaa aatccaggat ccaattatca agtccaatgc caaagagact
      241 ctcacaggat taaaaaataa tttactattt ggcacccagg acaacaatac tattatggca
      301 gaagctgaaa aactattggc tttattaaag gagagtaagt aaaggtagca gcattttcta
      361 actcctaaaa acaggatagg agaacgggaa aacgaaaaat gagagcagaa tgtgagttct
      421 agttctcatt tttttcatga aaatgtgcaa aatatagtag attgaaacta gaatagtata
      481 cctctacttc taaaacattg ttagaaatcg atttgactgt cctgttctta tttcatttta
      541 ctatatctta acagatagtg taaataaaga taaactattt actggctaat taatcagtta
      601 aacactagtt aaggagtaat gatgaaaaaa agaacaatac tattattaat ggccagtctg
      661 ttagctcttg tcttaggagc atgtggtttc ttggacatat tgatcctgga tcattctcat
      721 caggattact ctttactgct attttagaaa ctggggtggt ttgatggaaa gtattggtat
      781 tggtcttgtt atcgtttcac attccaaaca cattgcagaa ggtgttgttg aactgattag
      841 taaagtagct aaagatgttc cgattactta tgtaggagga accgagggcg gaggaattgg
      901 aacgagtttt gatcaagtag atagggttgt ttccgaaaat ccagcagata ctttacttgc
      961 cttttttgac ctaggttctg ctataaaatg ttaagtaaat gatttcaaaa tcagaaaggg
     1021 attgctttat gcagttcctt tttattttaa caggagtgaa actatagtgt ttctaaattg
     1081 tgaatcaatc aaaactgatt gtgatggggc tattctagct ttagaaacct tcaaaaatta
     1141 aaatttaagg caatcaatta cttggaagag tatgaaagca tttagtttat aggaattcta
     1201 ggcctagaat tacatatgta tttatgaaga cggggtgttc gatagttagt attgttctat
     1261 tctgaaagat ttgagctgtc agttgtatag aaagtgttcg aatttttttt aagtgattaa
     1321 attagttaat tgtatgaggt gctttatgat ataatgttct taatgaattt tcagaaagga
     1381 aaacctcaaa ttgttctaca aatttctact cttcgacctc gaccacactc ttcttgattt
     1441 tgatgctgct gaggatgtgg ctttgaccca acttctaaaa gaagaaggag ttgcggatat
     1501 tcaggcttat aaagattatt acgttcctat gaacaaggct ctctggaaag acttggagct
     1561 gaagaaaatc agtaaacaag agctggttaa cacgcgattt tctcgtttat ttgctcattt
     1621 tggacaggaa aaagacggta gttttcttgc ccagcgttac caattttacc tcgcccagca
     1681 gggacaaaca ctatcgggcg ctcatgatct cttggacagc ctcattgagc gtgattataa
     1741 cttgtatgct gcgacaaatg gcattactgc cattcagaca ggacgtttgg ctcaatctgg
     1801 tctagcacct tatttcaatc aagtctttat ctcagaacag ttgcaaactc aaaagccgga
     1861 tgctctcttt tatgaaaaga ttggccagca aattgctgga tttagtaaag aaaagacgct
     1921 gatgattgga gattctctaa ctgccgacat tcaaggtggc aataatgcgg ggattgacac
     1981 tatctggtat aatcctcatc acctcgaaaa tcacacacaa gcccagccga cttacgaagt
     2041 ctattcttac caagacttgc tggattgttt agataaaaat attcttgaaa agatcacatt
     2101 ttaaaggaga cgagctaatg actacaaaaa agctaatatt actattgaag agtacattga
     2161 aatgtctgaa gttgatttta atgaagctgt taattatgaa tttacatctg acacttgtca
     2221 attagcaaat agtatttatc aatctctttt taagtttttt gataagaaaa atttctctgg
     2281 cgatttaatt tttacttgga aatctccatc attagtcaaa gaaagggatt atattgggag
     2341 aagggattca caagtagata atcttagagt aataggaaat atatttctga attatcttac
     2401 taatcgaaaa tatagcctca atatgaatcg taatggctgt atgggagatt ttcctcatga
     2461 cttttttgat atatacctag atcatgtagc aaaatatgcc tacgaacaaa aagttaataa
     2521 tattaaagag tattatcctt taaaaagagc gattttacac caagagaatg cattgtattt
     2581 tcgatttttt tctaattttg acgacttttt agaaaaaaat tatttaaaga ctatatggca
     2641 agtttctaaa gaaactcctt tttctgaaat ggattttaat atgtttaaaa atatttcaga
     2701 aaagataatc ttcgaaagag gtagtaaaat gcttaatgat ttaaaaagta attataaaaa
     2761 atagccagtc tttataaact gtattcacgt attcaaatcg tatatagtcg atttattaaa
     2821 tctttagata aactgtaaaa agtggtttcc atagccactt tttgctataa tagaggcagt
     2881 aaaaatgaag gagtcggcta tggaacactc gtcttggcat gctttgatta aggcgcaatt
     2941 acctgagggt tatttcggga aaatcaatca gtttatggag caggtctatt ctcaggggat
     3001 tatttatcca cccaaggaaa aggtttttca ggctctcttg acaacactgc ttgaagaagt
     3061 taaggtggta attctagggc aagaccccta tcacggacca ggtcaagcgc agggcttgag
     3121 tttttccgta cctgactcta tcccagctcc accatccttg caaaatatct tgaaagaatt
     3181 gtcagatgat atcggagtta agaaatctca tgatttgaca gcttgggctg agcaaggagt
     3241 cttgcttctt aatgcttgtt tgactgttcc tgctggacag gccaatggtc atgctggtca
     3301 aatctgggag ccttttactg atgctgtgat tcaggtggtc aatcatctag atagaccagt
     3361 cgtttttgta ctctggggag cttatgcacg taagaagaag gccttagtta ccaatcctca
     3421 tcacttgatt attgaatcag cccatccaag tcctttgtcg gtttatagag gattttgggg
     3481 ttccaagcct ttttccaagg ccaatacatt cttaaaagag acaggacaag agccaatcga
     3541 ttggcttaga taaggagaaa atatgcctca gttagcgacg atttgttaca ttgataatgg
     3601 gaaagaactg ctcatgctcc atcgtaataa gaaacccaat gatatccatg aagggaaatg
     3661 gattggtgtg ggtggtaagc tagagagagg agagacgccc caggaatgcg cggtacgtga
     3721 aatccttgaa gaaacagggc tcaaagccaa gccagttcta aaaggtgtca tcacttttcc
     3781 tgaatttaca ccagatttag actggtacac ctatgttttt aaggtgacgg agtttgaggg
     3841 cgacttgatt gactgcaatg aggggacgct agaatgggtt ccctatgacg aggttttgag
     3901 caagccgact tgggaaggtg accacacctt tgttgagtgg cttttagagg ataaaccctt
     3961 cttttcagcc aagtttgttt atgatgggga taaattgttg gatacccaag ttgatttcta
     4021 tgaataaagg agaaagcaga tgctactaat caaaaatggt cgtgtaatgg atcctaagtc
     4081 tggtttggat caagtttgtg atgtcttagt tcaagatggg aaaattatca aaattgcgcc
     4141 tgagatcacg gaagaaggag cagaaacgat taatgctact ggtcttgtgg ttgctcctgg
     4201 tttggtcgat attcatgtgc atttccgtga acctggtcaa acacataaag aagacattca
     4261 tactggtgcc ctagcagccg ctgcaggtgg ttttactact gtcgtcatga tggctaatac
     4321 cagtccaacc atttcagacg tggagacttt gcaagcagtt ctccagtcag ctgccaaaga
     4381 gaagattaat gtcaagacag ttgcgaccat tactaaaaac tttaatggta aaaacttgac
     4441 tgactttaag gcactcttag aagctggtgc ggttggtttc tctgatgacg gtattccgct
     4501 tgagagcagt aagattgtca aggaagccat ggaggaagcc aaaaaactca atacctttat
     4561 cagccttcat gaggaagatc caggtttgaa cggtgttctt ggctttaatg aaaatattgc
     4621 tagagaacat ttccatatct gcggtgctac tggggtggct gagtacgcta tgatggcgcg
     4681 tgatgtcatg attgcctatg caactaaagc ccatgttcac atccagcatt tgtctaagga
     4741 agaaagtgtt aaagtagtgg agtttgctca ggggttaggt gcagaagtca cagcagaagt
     4801 agcgccacag catttctcta agacagaagc acttctttta acacaaggta gcaatgctaa
     4861 gatgaatcca ccgcttcgtt tggaatcaga ccgtcgtgcc gttatcgaag gtctcaaatc
     4921 aggtgtcatc acagttattg cgactgacca cgcgcctcat catgtagatg aaaaaaatgt
     4981 tgaggatatt accaaagcgc catctggtat gactggctta gaaacatccc tgtctctcag
     5041 cttgacctat ttagtagaag ctggtgagtt gagcttgatg gaattacttg aaaaaatgac
     5101 atacaaccca gccaagcttt acaactttga agcaggttac ttggctgaga atggtccagc
     5161 agatatcact atttttgatg ccaaggctga ccgctttgtg gactcccatt ttgcttccaa
     5221 agcagctaat tcaccattca tcggtgaaac cttaaaaggg caggttaaat ataccatctg
     5281 taagggacaa atcgtctatc aagcttgata ggagttagaa tatgaattat tttcgaaaac
     5341 gtagggagag acaagcgaaa tctaatagtg gaatttactg tcccgcagct aatcgttcca
     5401 aaattcaata tgaaactaaa gaaaaagctg accatgcggt tcaatatgat aacggaggtt
     5461 tagttagaag ctattattgt cgtacatgtg cgtgttggca tactacttca aaatctaata
     5521 aacctccgct aagtttgaaa aactatggtc tgaaactctt tggtttagat aaatcagaat
     5581 agaaagagaa gtatgtataa gacaaagtgt ttacgagaga agttagtatt atttttaaaa
     5641 attttcttcc caatcctgat ctaccaattt gccaattatt ctgcctcttt tgttgatact
     5701 gcaatgacag gtcaatacaa cactatggac ttggctggtg tatctatggc aaccagtatc
     5761 tggaatcctt tctttacatt tctaacaggg attgtgtcag ccttggtgcc tatcattggt
     5821 caccatcttg gtcgaggcaa aaaggaagaa gttgcgtctg atttttacca atttatttat
     5881 ttggccttgg gcctatctgt ggtcttgctg gggatggtac ttttcttggc accaataatc
     5941 ttgaatcata ttgggttaga agcagcagta gcggcagtag cggttcgcta tctttggttt
     6001 ttatctatcg ggattatccc cttgttgctc tttagcgtca ttcgttcctt gctggattcg
     6061 ctgggcttga ccaaactgtc catgtacctc atgcttttgt tactccctct caatagcgga
     6121 tttaactatc tcttgattta cggtgccttt ggtgttccag aactgggagg ggctggtgct
     6181 ggtttaggaa catccttggc ctactgggtc ttgcttggga tttctgttct ggttttattt
     6241 aaacaggaga agctcaaagc cttacacctt gagaaacgaa ttccacttaa tatggataaa
     6301 attaaggaag gagttcgttt aggtctgcct attgggggaa ctgtcttcgc ggaagtggct
     6361 atcttttcag tggttggctt gattatggct aagttttcgc ccttgattat agctagtcac
     6421 cagtcagcta tgaacttttc aagtcttatg tacgcctttc ctatgagtat ctcatcggct
     6481 atggctattg tcgtttccta tgaagtggga gccaagcgat ttgatgatgc gaaaacctat
     6541 attggtctag gaagatggac tgccctcatt tttgcggcct tcaccttaac cttcctttac
     6601 atttttaggg gaaatgtggc cagtctttat ggtaacgacc caaaatttat cgatttgaca
     6661 gtgcgttttt taacttatag tcttttcttc cagttagcag atacctttgc ggcgccgctt
     6721 cagggaattt tgcgggggta taaggataca gttattcctt tttaccttgg tttgcttggt
     6781 tattggggcg tagcaatccc tgtggctacg ctatttgatt ccctaacaga ttttggagct
     6841 tattcttact ggatcggctt gattattagt ttgattgtga gcggggcgct ctaccgttgg
     6901 cgtttaactg tgattatgaa gagatttgaa tctttagcaa aatccaaatg ctaaaaagtt
     6961 tgtgaaaaaa tattcttgac aagaaaatcc cttgttttca cggggttttc ttttttattt
     7021 tgtgaaattt cttttagaaa aactttgaca gtatttgcca aaagcggtaa aatagtaagg
     7081 taagaagaaa gttagaaagg caagaagatg tcaactttag ataaaaatct tttgctagaa
     7141 atgttccgta agatggaaga aatccgtcgc atggacttaa aaattgcaca attagtaaag
     7201 aaagggaaag tgccaggaat gacgcacttt tctgttggtg aagaggcagc taacgtgggg
     7261 gctatgttag ctctcaatcc agatgatctg attacctcaa accaccgtgg acacgggcaa
     7321 gctattgcta aagggattga cctcaacgga atgatggctg aaatccttgg taaatacact
     7381 ggaacctgta aagggaaagg tggatctatg catatcgctg accttgatgc tgggaacctt
     7441 ggtgccaatg gtatcgtagg tggtggtatg gggatcgctg tcggtgcagc cctcagtcag
     7501 caaatgcaaa ataccggtaa aatcgttgtc tgcttctttg gagatggtgc gaccaatgaa
     7561 ggtgttttcc acgaagcagt gaacatggct tctatctgga acctgccagt cattttctat
     7621 tgcattaaca acggttacgg tatctctgcg gatatcaaga aaatgaccaa tatagaacat
     7681 atccatcaac gtagcgccgc ttatggaatt cctggaatgt tcatcgaaga cggtaacaat
     7741 gtcatcgatg tctatgaagg atttcagaaa gctgtggacc atgttcgcag tggcaatggt
     7801 ccagtcttga ttgaaagtgt aacttatcgc tggctcggtc actcatcatc tgaccctggt
     7861 aaatatcgta cgcgtgaaga agtggaattg tggaaacaaa aagatccaat cgaaaacctc
     7921 cgcaattacc ttattgaaaa taacattgca agtgccgaag aattggaaga aatccaagcg
     7981 caagtaaagg aagcagtaga agcttctgtt aaatttgcag aggaaagccc attcccaccg
     8041 cttgaatcag cctttgaaga tatttacgca gactaaggag aaagagataa aatggaaaca
     8101 aaaacaatgt ccttccgtga caccattatc cttgctatgt ctgaggaaat gcgtcgcgat
     8161 gaaaatgtgt tcttgatggg agaagacgtc ggtgtcttcg gaggagactt cggtacttct
     8221 gttggaatgc ttgaagaatt tggtccagaa cgtgtccgtg actgtccgat ttctgaagct
     8281 gccatctctg gagcagcagc aggagcagcc atgacaggac ttcgtccaat cgtcgatatg
     8341 accttcatgg acttctctgt tattgccatg gacaatatcg tcaaccaagc tgctaaaaca
     8401 cgttacatgt ttggtggtaa aggtcaggtt ccaatgactg ttcgttgtgc agctggtaac
     8461 ggagttggct ctgccgccca gcactcacaa tctctagagt cttggtttac tcacattcca
     8521 ggacttaagg ttgtggcacc tggaacacct gcggacatga aaggcctgct taagtcttct
     8581 atccgtgata acaacccagt tattatactt gagtacaagt cagaatttaa ccaaaaaggg
     8641 gaagtgccag ttgatccaga ctacacaatt ccacttgggg ttggtgaaat caaacgccaa
     8701 ggaacggatg taacagttgt tacttatgga aaaatgcttc gccgtgtggt tcaagctgct
     8761 gaagaattag cagaagaagg aatttcagtt gaaattgttg acccacgtac ccttgttccg
     8821 cttgataagg atatcatcat aaactcagtg aagaagactg gtaaggttgt tctggtcaac
     8881 gatgcccaca aaacaagtgg ctatatcggt gaaatttcag ctattatttc agaatcagaa
     8941 gcatttgact atctagatgc accaattcgc cgttgtgcag gagaagatgt gccgatgcct
     9001 tatgcacaaa acctagaaaa tgcaatgatt ccaacagttg aaagtatcaa agatgcaatc
     9061 cgaaaaactt ataacaaaga atagggttac ataagataag ttatgtaaat aaaataaagc
     9121 tgacgagaaa ctttgtatct tttaggtgca gagctcttcg tcattaatat cttagattag
     9181 agcacgggct aaaagatcgg aaaaaagata aatctccttg gcttcatcga agccatcgtc
     9241 gatttcctat ttttcagtcg cttttgacgc cctttgtatc ataaatagaa ttggagaggt
     9301 catggctgat gacaagctaa gagcgactcc tgcagctaga aagttagcgg atgatttagg
     9361 gataaacctc tacgacgttt ctggctcagg tgcaaacggt cgtgtccaca aagaagacgt
     9421 ggaaacttat aaagacacaa acgtggttcg catttcgcca cttgcaaaac gaattgccct
     9481 cgaacataac attgcttggc aggaaatcca aggaaccggt catcgtggta aaatcatgaa
     9541 gaaggatgtt ttggccctgc ttcctgaaaa tatcgaaaac gatagcatca aatctcctgc
     9601 tcagattgaa aaagtggaag aagtccctga taacgtaaca ccatatggta aaatcgagcg
     9661 tattccaatg acaccaatgc gtaaggttat tgcccaacgc atggttgaat cttacttgac
     9721 tgcgccaacc ttcaccctca actatgaagt tgatatgact gaaatgttgg ctcttcgtaa
     9781 gaaggttctt gagccaatca tggaagcaac tgggaagaag actactgtaa cagaccttct
     9841 ttcgcttgca gttgttaaga ctcttatgaa acacccatac atcaacgctt cattgacaga
     9901 agatggcaag actattatca ctcacaacta tgtcaatctt gccatggcag ttgggatgga
     9961 taatggattg atgacacctg ttgtttacaa tgctgagaag atgagtcttt cagaactggt
    10021 tgtagccttt aaggatgtta ttggccgtac cttggatggt aaattggctc caagtgagtt
    10081 acaaaattca acattcacaa tcagtaattt gggaatgttt ggtgttcagt cctttggtcc
    10141 gattattaac caacccaact cagctatcct tggtgtcagt tcgacaatcg agaagccagt
    10201 tgtcgtcaat ggtgaaattg tgattcgccc aatcatgagt ttaggattaa ccattgacca
    10261 ccgtgtcgta gatggtatgg ctggtgctaa gtttatgaag gacttgaaag agttgattga
    10321 aacgccaatc tcaatgttaa tttaagagca agagtattca tttttaagat atagataaag
    10381 gaaggaagac atggccttag aagtaattat gccaaaagcc ggcgtggata tgacagaagg
    10441 acaaatcgtc caatggaata aaaaagtcgg agaatttgta aaagaaggag aaatcctttt
    10501 ggaaatcatg actgataaag tcagcatgga attggaagcc gaagaagatg ggtacttgat
    10561 tgccattctc aaaggagatg gtgaaactgt ccctgtaacg gaagttatcg gttaccttgg
    10621 tgaagaaagg gaaaacatcc caacagctgg agcagcatcg ccagaagcta gccctgtacc
    10681 tgtagcaagt acctcaaacg atgatggtaa gagcgatgat gcttttgata tcgttgtgat
    10741 tggtggaggt cctactggtt atgttgcagc cattaaagct gcccaactcg gcggtaaggt
    10801 tgcccttgtt gagaaatctg aacttggtgg aacctgctta aaccgtggat gtattccaac
    10861 caagacctac cttcataacg ctgaaattat tgaaaatatc ggtcatgctg caaatcgtgg
    10921 tatcgtgatt gaaaatccta acttcactgt tgatatggaa aaacttttag aaactaaatc
    10981 taaagttgtt aatactcttg ttggtggtgt tgcaggactt cttcgtagct acggagttac
    11041 tgttcataaa ggaattggta caatcactaa agacaagaac gtcttggtaa atggctctga
    11101 attgcttgaa accaagaaaa tcattcttgc tggtggttca aaagtcagca agatcaatgt
    11161 ccctggtatg gaatctccac ttgtcatgac tagtgatgac attcttgaaa tgaacgaagt
    11221 gccagaaagc cttgttatca tcggtggtgg agttgtcggt atcgaactcg gtcaggcctt
    11281 catgacattt ggttcaaaag tgactgttat cgaaatgatg gaccgtatag ttccagctat
    11341 ggatgcggaa gtttctaaga accttcgctt gatccttgag cgtaaaggaa tgaccatctt
    11401 gactggtact aaactgcaag aaatcattga ggaaaatggt caacttcgta tcaaggttga
    11461 aggaaaagac gatatcatcg caagcaaagc tcttctttca attggtcgta tgccagacct
    11521 tgaaggtatt ggagaggttg agtttgaatt ggatcgtgat tgtatcaagg tcaatgaata
    11581 catggaaact tcagttccag gcatttatgc accaggtgac atcaacggta ctaagatgtt
    11641 ggctcacgca gctttccgca tgggtgaagt ttccgctgaa aatgccctta aaggaaatca
    11701 tgcagttgcc aaattgaatt tgactcctgc agccatctac actctccctg aagtagcagc
    11761 agtaggtttg acagaagaac aagcccgtga gaaatacgat gttgccatcg gtaagtttaa
    11821 ctttgctgct aacggtcgtg ctattgcatc tgacgcagct caaggtttcg taaaagttat
    11881 cgctgataag aaatacggag aaatccttgg tgtacacatt attggtcctg cagccgcaga
    11941 attaataaac gaagcatcaa gcatcatcga aatggaaatc actgttgagg aaatgctgaa
    12001 gaccatccac gggcacccaa cttactctga agtgatgtac gaagcgtttg cagatgttct
    12061 aggaatggcc atccattcac ctaagaaaaa ataaaacgaa gatagattag actggaaggt
    12121 tatttccagt ctctatcata taaagtaaag ggatatcatg aaatacatta tcaatcattc
    12181 aaatgacact gcttttaata ttgccttgga agaatacgcc tttaaacacc ttttggatga
    12241 ggatcaaatc ttcctacttt ggattaacaa gccatctatc attgttggtc gtcaccagaa
    12301 cactatcgaa gaaatcaacc gtgattatgt tcgcgaaaat ggtattgagg tagttcgccg
    12361 tattagtggt ggtggagctg tttaccacga tttaaataac ctcaactaca cgatcatctc
    12421 caaagaagat gaaaataagg catttgactt caagagcttc tcaactccgg ttatcaatac
    12481 cctggctcaa cttggggtta aagctgagtt cacaggtcgt aatgaccttg agattgatgg
    12541 taagaagttc tgtggcaatg cccaagccta tatcaacggc cgtatcatgc accacggttg
    12601 cttgctcttt gacgttgatt tgtcagtcct cgcaaatgcc cttaaggttt caaaagataa
    12661 atttgaatca aaaggtgtga aatccgtccg tgcccgtgta accaatatta tcaatgaatt
    12721 accaaaaaaa atcacagtcg aaaaattccg tgatttactc ctggaataca tgaaaaaaga
    12781 gtacccagag atgactgaat acgtcttttc agaagaagaa ttggccgaaa tcaatcacat
    12841 caaggatact aagtttggaa cttgggactg gaactatggt aaatcacctg aatttaacgt
    12901 ccgtcgtgga accaaattca ctagtggtaa ggttgaagtc tttgctaacg ttactgaatc
    12961 aaaaatccaa gacatcaaga tttatggtga cttctttggt attgaagacg ttgctgcagt
    13021 agaagatgtc cttcgtgggg tgaaatacga acgcgaagat gttcttaagg cgctaaaaac
    13081 cattgatatc acacgctact tcgctggtat tagccgtgaa gaaatcgctg aagcggtagt
    13141 tggataaatc aaaaaaagaa gttagccaac ttcttttttt gatatttatt tacataattt
    13201 aaaatacgta aaatcataaa ctatctagag cattcttttg ttcatcatta acaatatggg
    13261 tatagaggtc agtgacttgt gtgctggcat gtcctagttg gtgactgact aaaacttgtg
    13321 atttagtcgc atcatagagc ctagttgcta gcgtatggcg cagtttatgg ggtgttacac
    13381 gcactttaaa atcctctgag tatttagcaa ccattttctc aacgctagaa gcatcgatac
    13441 gattaggaac acctctgtag agagttaaaa aaagggctgt atctgttttt tccgttttat
    13501 agcgttgatt ccgaatggcc agataattct ctaaataagg tttagcaaaa gcagcgacat
    13561 tgactgagtc acgtttgcca ccttttcgag taacatcaat aaccatcatt tttagattga
    13621 gatctcttag atctagatta acagcttcag ataagcgaac accagatgcc aagagaaggg
    13681 caataatggc taaatctcgt tctttatttt tgttgaatga tgagagagct cgatttgaaa
    13741 gctgttgtgg gtgctcttga tcgatataag ttagaaaacc ttctgtttca tcacctagaa
    13801 agagtttttg cttgatattt tcagctctgg cagcaagggt ttctttcttt ttcttggttg
    13861 aaactttttt cattacatta cgatagaaat aaggttcccc ctgatcgttt tcaacctcct
    13921 cggttagata cttgtaaaga ctagaaagtg ctgataaggt tcgattgata gttgtctgtg
    13981 aaacaccttg ttttgttgta ttagcattca gcaagggacg ttcacgtaga taaaggataa
    14041 aggattccat gtctttctta gacatatttt ccaaaactga taaaggaata tcggatattt
    14101 tatcagcgtt tgaaatacca gactccaaaa cccagctgaa aaatcggtca tattccttaa
    14161 ggtattcgta cagggttgta aaactgtagg gcacagccag cttagattgg tagtattcca
    14221 gaacatacca gggcatgagt tgttttagtt tgtcgattcg ttccagtaaa atctcacgtt
    14281 tcatgtattt tctccataag taagtatact agtagtatag catagacttg tatatttttc
    14341 aagaaaatta tagtttttct gaaagatgtt ataggagttt ttcaaagtga taaaaagact
    14401 tagacctaca aacaaaacag aataaggaaa ataataaaaa tctcacccac taaacttctg
    14461 ttaatactac ataactgaag agctatataa ggagctatga gatacaaaac acattgtata
    14521 atagattgaa actagaatag tacatctgaa cttctaaaac attgctagaa attgatttga
    14581 ttgtcctgat tgttttatcc tatttctatt tcatttcact atataattgc tattgttttc
    14641 tttttcatga ttttaatctt actgtacaga tttgatacag taaactcctt tctagcttta
    14701 tactttatca tttctaactt aattatagtc ttatttttaa taaagttcaa ttatttatat
    14761 gtaaaattcc tcatcagtaa aaaataaccg atctcatttc tgagaatcgg ttttctaaat
    14821 aaatcaagcc aatcatttac ataatataaa ttatgtaaat gattgtacta caacaacaaa
    14881 tctttgactt ttccaatttc actttttgga ataaccaggt gaatcatatc acccagatac
    14941 attctggttg agccgttaac tgtttggctc ttgccattat ggacttgagt tgtgatgagg
    15001 acgttgtgtg gtaagttgag ttcatgaact tgtttcccag caattttatc agaaactggt
    15061 atttcgataa gtgtaacttc tccttcgcta gatacttctt ctggaagcat tttttccagc
    15121 atggcttcat agactggcgt acctttgagc aaatccatga taatataaga aacaagagtg
    15181 acaagaccaa gtggcatgag gttgcgaata tctcctacca tctcagttac gaggatcata
    15241 gcggttaagg gagcttttga tatggctcca aaatagccac tcattcctag aatgacaaat
    15301 atagggaatt gctcttgact gacaagtcta agattgacac agataacacc aattaaggca
    15361 ccaagcaaag aaccaagagc taaaatgggg aggaaaattc ctcctggcag tccacttcca
    15421 tagctaatca tactccaaat aaagcggatc aaaaagtaag ctaataaaac ttggaaacta
    15481 aaattttgtt cagttaaaga aaggacaagc tgatttccgc caccaatgat ttgaggtaag
    15541 aagattccga ctggtatgat aaggataaaa gccaagatgg gataataagc tctatccaaa
    15601 tggatttttt gaccaatcaa gtcataaact cttccaacgt ttaatacagc tttctcatag
    15661 agaaagcctg aaaatccaag gaaaattccc atgacgagat atatccaata ctgatctagg
    15721 gtcatgggag gaatgttatc tggcatatcc aatactggtg tcaaaccgaa catgagtaga
    15781 gacacaaagt ttgctacgat gctggctgct agagttgaga cccagaaaaa gcgcgaaaaa
    15841 tggtgataga cttcttctac aacaaagaga agtgctgcaa taggagcatt aaaggctgcg
    15901 gctaaacctg ctgcagctcc actggcaatc aaggaacgtt cctctactgg actggatttg
    15961 agccacttgg caattccttt accaccaact gctccaagtt gaatactggg tccctctcga
    16021 cccagcatga gtccactggc aatagcgaga atacctagca catatttttt ccaaagaatg
    16081 ccccaccagt tgagggacat gaggcctttc agttcggctt cgacttgagg aattcctgag
    16141 cctttaatat ctttttctga ccgtgttagt ttggcactga gccaacagat gagtatataa
    16201 aacaaaacca gtacaaaaag attgcgcact aagtaccctt gatcttgata aactccttgt
    16261 atcatgtgga agcccttttc aattaagaaa cgaaaggatc cgacgataat tccaacgatg
    16321 aggccgacaa tgattcctcg accaacttgg gatagtatag tgctggatgc aaaggcgaat
    16381 tctttcttag aacggactat ttccgactgt tcctccatgg tatttccttt caattaactt
    16441 tcttttttac ctaaaaccag tgatttaacg ggttcaaagc tggttcggtg aattggggta
    16501 actcctagtt ttgtgaggcc ttccagatgt ttagctgtgc catatcctgc attagtagcg
    16561 aaatcatagc cagggaactg ctgatcgtat tctttcatca attcatcacg tgttaccttg
    16621 gctactatag atgctgctgc gatagagagg gagttggcat ctcctttgat aatggaggtt
    16681 tgtgaaatgg gcaagtccag tttcatggca tcaatcaaaa ggtgctctgg ttgagggctg
    16741 agctgggaga ttgcttcttg catggctagt ttggttgctt catagatgtt gacttggtcg
    16801 atgacctgat tatctatgat accaattcca atcgacaagg cttggtcttg aacggcttgg
    16861 aaaatctcca gatgtttctt tttaggaatt ttcttgctgt cgttgagacc tttaatctta
    16921 caatttttag gtaaaataac ggccgcagcg actacaggac cagcaagagg accacgacca
    16981 acctcatcaa tacctgcaat taaggtcaat ccttgcttat aaagttcttt ttcataagaa
    17041 agcatggatt ccaagcgcaa attttcatct aattcagctt ggatggctct tttacgcttg
    17101 ctgatttcct tttgaactcc tgagcgatta tccttttcaa gctctaaaaa aatagggctt
    17161 tctaactcct tgactgtcac aaggagttct ttgatttctt taatcgttgc catcgaggtc
    17221 ttccaatgta tctaaggtat agttaccgag tttgccatca cggacttcct tcacgaagag
    17281 actgtaaaaa cggtcatagt catcacggaa accgagggcg cgggtcatat ccataataat
    17341 cacagacggt tcttcttcaa ttttcatttg tttgaagcgt tcagccagct tttctggata
    17401 atgttctttg aaataattga taccaaaaat ggtaacctca tccataggaa gcaactggtc
    17461 tttgatagct ccagtcaatg ccaacttaag tgcaacagtt tcatcctcaa acttaggcca
    17521 gagaatcccc ggtgtatcca agatttccag gtctttattg gttttaagcc attgttgacc
    17581 ttttgtgacc cctggcttgt ttccaacaac agcaatcttt ttaccagcca aacggttcat
    17641 cagagttgat ttaccagcgt ttggaatccc gataatcatg gtacgcaagg tttcaatctg
    17701 aatcccacgt tctttctggc gagcaatctt atcagccatg agcttcttgg ccgcatctgt
    17761 tacaactttt acagtcactt gctctttgga gttgatagct agcgtctgga ttccttgtga
    17821 ttcaaaatac tgacgccatt ccttggtcat tgctggatca gccaagtcgg ccttgtttaa
    17881 aatcaagagt tttggtttat caccaacaat cttggtcaac ataggatttt gactagatag
    17941 aggcaagcgt gcatctacta aaatcgtcac aaaatcaaca aattttaaat tctcctgcac
    18001 ctgtcgacga gctttagaca tgtgaccagg aaaccattga atagtagcca ttgagttttt
    18061 tcctttcgta gctctgaagc tgttaatcta gaactaagag atctcaatct aaaaatgaat
    18121 gatgtccaaa cagttcttgt tttatgacat aaaaatctac tttatattat atcatgcctt
    18181 ctttattttg tccgatgata gccttttacc ctatatagaa aaaagccatc aaatgatgac
    18241 ttttcagagg gagcaaaaaa ctgtcctctt tatgttttaa acatttaacc caaatcattc
    18301 atacctctct caactagatg taacttacaa aacccctgac ctcatgtcct catgaggtca
    18361 gttttacttt ctgctgttcc agtatcgttt ttcctcgcta gatttcctca aaagggcaga
    18421 ctcctccctt ggtgcgtcac acgatttttt catctcgact gttctttaat gcatcattaa
    18481 cgacgctttt cttctaggtg gttcataagg aacaggaaga ttcaggttga cttttctaat
    18541 cctagaataa agtgctgaaa acaattcgga ataggcatag agactagaca atttgaggag
    18601 ctgcttgcgt cctgttcgaa cacattttcc taccacgtga agaaaaagat ggcggaagcg
    18661 tttgattgtt aaagtttgga agtcacctcc agctagatgt ttgagaaaaa gatagagatt
    18721 gtaggcgata cagctcatca tcatacgaac ttcgtttttg attaaggttg aactatccat
    18781 tttatcgcca aaaaatccct ccttcatctc cttgatgaaa ttctcggctt gaccacgtcc
    18841 acgataaagc tgaaactggt cttggcttgt tccactcgtc atatttgtaa cgagagaaat
    18901 aacatcgtag aacaagtttc cttcttttcg ttcagagaac tggcagacac gacgcttgtg
    18961 cgaccaagat cctgcttgat agagagtttc tgagtaggcg gagtggggca agatggttaa
    19021 gtcctcatcc tgtgggcaag ggagggaaag gtctccaaga cagctcagaa cagtattttt
    19081 cttgagttt
//
LOCUS       DBERMM010000038        18738 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.038, whole genome shotgun sequence.
ACCESSION   DBERMM010000038 DBERMM010000000
VERSION     DBERMM010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 18738)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18738)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18738
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.038"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            204..1685
                     /gene="mgaSpn"
                     /locus_tag="ACL8AS_001622"
                     /gene_synonym="mgrA"
     CDS             204..1685
                     /gene="mgaSpn"
                     /locus_tag="ACL8AS_001622"
                     /gene_synonym="mgrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="virulence factor transcriptional regulator
                     MgaSpn"
                     /protein_id="HGS1229449.1"
                     /translation="MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKD
                     DLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQ
                     AESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSE
                     KYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFME
                     VDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESL
                     FMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEF
                     ILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHL
                     VINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSP
                     YDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE"
     gene            2047..3042
                     /locus_tag="ACL8AS_001623"
     CDS             2047..3042
                     /locus_tag="ACL8AS_001623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HGS1229450.1"
                     /translation="MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQR
                     AIKTLDYIPDNYARGMKKNRTETIALIIPSIWHPFFSEFAYHVEKELLKYNYKLFICN
                     ADSDSQNEIEYIEMLKQNKVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSA
                     NYKGGQTAAEELVRRDNKHLAFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKE
                     PLINPEDQIRIFLQSHKEIDGIFTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKT
                     SVDQSYLVSTIVQDIGMMAKESVAMILKMIKREEILEKRIVIPTYFWGDKTTKKI"
     gene            3170..4480
                     /locus_tag="ACL8AS_001624"
     CDS             3170..4480
                     /locus_tag="ACL8AS_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HGS1229451.1"
                     /translation="MRKGTMLSVVAGLSLAILAGCSGGTNSKQASSSNDIKVWVQFSD
                     ETNEGKAWQKVVDNFNQSGKSKYKVVTEYIPRSGSGGGYEDKVNAAITTNSLPDVITL
                     DGPNTAAYAKSKVITPLDDYLKDNNMDDVLDSIKQQGTYNGKFYAFGFSESNVGVYYN
                     KKMFKEAGIAESELPTLEKPWTWDEFNTIAKKLKDHYNKPAIDFRINSNDEMLPYAYM
                     PLIWSNNGSVVNEDGTKAEGYFNSKESVEAVQFIQNLVKEGYTTVSPVEKGFETGEYP
                     MLLSGSWTIADMNTNYKDIDFGILPYPVSSKTKKLVSPSGSWQLAVTTKSDKKEAASE
                     FVKFATNTESSEIISLGNSVLPIRKSTIENIKDKVSEPMRFLMEQNSKTAHARPVVVA
                     YPQVSRAFQQAMQDISYYEENPNVQKVLDTRTKEMQTAIDQSLK"
     gene            4576..5478
                     /locus_tag="ACL8AS_001625"
     CDS             4576..5478
                     /locus_tag="ACL8AS_001625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1229452.1"
                     /translation="MSKETVVDTKRREKIKDNILGYSFLAPALILLGIFLVIPVGMVI
                     YYAFTDYYLLTPDERKFVGLENFIRLTKDPIFLKSFLNTLKFVVWIIPVQLGAALGMA
                     LIVNKKRKGNMFFKVAFFAPVVMSLVVISILWLYLLNPNSGLLNAILNKVGIASQPFL
                     TSPKQAMYAIVFVSAWQGAGYQMLLFLGGMQNIPQDVYEAAELDGFSKWAQFRYITMP
                     LLKPTALFVLLTTLISAFKLIVQPMVMTQGGPLNSTITMVYYIYQQGFTDRLVGYSSS
                     IALVFTTLIGMISLVQRRVLKEDD"
     gene            5480..6325
                     /locus_tag="ACL8AS_001626"
     CDS             5480..6325
                     /locus_tag="ACL8AS_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HGS1229453.1"
                     /translation="MKRFKPTTILEYILLTLLAGLFLFPMVWMVVSAMKPEADVYKNL
                     TSWQAFLPSLNPADWFKPYQEVFERFSIFTYLGNSIFYAGTFAIGSIIVNALAGFAFA
                     KVNFSGKKILFGFLLALLIIPVETVLIPQFTIINSLGLVNNRLAVIIPGLASVFNIYL
                     FRNFFIAIPEEILESAKMDGASIVRIFFRIMLPMSKPAVATVGVLSFISSWNDYIWPL
                     MVLTDSSKFSMQVAITTINTTQPVYINQVMAVLTISTIPLILVYVVAQKYIVQGLGGS
                     GTGIK"
     gene            6335..7654
                     /locus_tag="ACL8AS_001627"
     CDS             6335..7654
                     /locus_tag="ACL8AS_001627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HGS1229454.1"
                     /translation="MINKTFTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNG
                     FVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSG
                     SAIVKDDRLWLMYTGHIEEETGVRQVQNMAFSDDGIHFEKISQNPVATGADLPDELIA
                     ADFRDPKLFEKDGRYYSVVATKHKDNVGCIVLLGSDNLVEWQFESIFLKGVEHQGFMW
                     ECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVEWGEKCFIPESVQEIDH
                     GQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQ
                     FPVKKGQYQIQIDKDCHYHLGNDIDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTS
                     RRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID"
     gene            complement(7864..7936)
                     /locus_tag="ACL8AS_001628"
     tRNA            complement(7864..7936)
                     /locus_tag="ACL8AS_001628"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(7901..7903),aa:Lys,seq:ctt)
     gene            complement(8201..9472)
                     /locus_tag="ACL8AS_001629"
     CDS             complement(8201..9472)
                     /locus_tag="ACL8AS_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001113185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HGS1229455.1"
                     /translation="MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMIL
                     YGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHR
                     LDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQ
                     IALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITL
                     DIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYTARLIEAGDLPSLAR
                     RLTVIAYEDIGLANPEAQIHTVTALDAAQRIGFPEARILIANVVIDLALSPKSNSAYV
                     AMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKI
                     RNHHYFQAEDTGKYERALAQRKEAIDHLRKI"
     gene            9742..9942
                     /locus_tag="ACL8AS_001630"
     CDS             9742..9942
                     /locus_tag="ACL8AS_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000818079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229456.1"
                     /translation="MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFRE
                     DTPKEILDLYENIKSKLDFAYQ"
     gene            10146..10325
                     /locus_tag="ACL8AS_001631"
     CDS             10146..10325
                     /locus_tag="ACL8AS_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229457.1"
                     /translation="MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDY
                     TDDELLDKEAVFTTH"
     gene            10462..10641
                     /locus_tag="ACL8AS_001632"
     CDS             10462..10641
                     /locus_tag="ACL8AS_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicA family
                     toxin"
                     /protein_id="HGS1229458.1"
                     /translation="MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGE
                     LNKYTERGIRKQAGL"
     gene            10678..11130
                     /locus_tag="ACL8AS_001633"
     CDS             10678..11130
                     /locus_tag="ACL8AS_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000961815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="HGS1229459.1"
                     /translation="MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAM
                     GSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSV
                     DVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA"
     gene            11421..11891
                     /locus_tag="ACL8AS_001634"
     CDS             11421..11891
                     /locus_tag="ACL8AS_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3013 family protein"
                     /protein_id="HGS1229460.1"
                     /translation="MATYGFLDVLEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNA
                     AGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNAEDYLTVIPYLPKKGFSREFLAYF
                     AIFLKDTAEVGLDTLMDFLEDPEAEEFVMEWNQEVFEEGKVGLEEGEFYPYPRY"
     gene            11910..12998
                     /locus_tag="ACL8AS_001635"
     CDS             11910..12998
                     /locus_tag="ACL8AS_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HGS1229461.1"
                     /translation="MKKIGTYLVYVLAFVFIMLAFACGTIAFAELGYSAVLAFTFGYA
                     FALLSMYLIFILHELGHAFCGYLTGYRLVAFGLGHFILTKKSGRFHLSRTAILKNVGA
                     QYIGLKEDESDQRIILMLSGGLMVHLGLILLAIVFGFLTRSWYFAGTWIFLNLSFFLN
                     NILPVDITDGAKIWELLQHPENTKYAYLVLRHSAQTLLAPQEYDLKDFVQAVPEDARG
                     SFADGVLGMQGEVSILEGKEEVAKQQFQALLERTTTPMMQTVAQLSLLHIALLEGDFE
                     QAEQYASIRQVKSFLSLKLSNLQVIQAWYQFKVKKDVDRTRKALKIARQKMDSSRMLR
                     DEKRYYENLLAELEKEMLEGTEDGTRNF"
     gene            12979..13407
                     /locus_tag="ACL8AS_001636"
     CDS             12979..13407
                     /locus_tag="ACL8AS_001636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HGS1229462.1"
                     /translation="MELEISDFPGCKIALFCGDKLLTILRDDKASIPWANMWELPGGG
                     REGDESPFECVAREVYEELGIHLTEDCLLWSKVYPSMLFADKQSVFLVGQLTQNQFDS
                     IVFGDEGQGYQLMNVEEFLSSSQVVPQLQERLKDYLKVSD"
     gene            13545..14495
                     /gene="prmA"
                     /locus_tag="ACL8AS_001637"
     CDS             13545..14495
                     /gene="prmA"
                     /locus_tag="ACL8AS_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000451122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HGS1229463.1"
                     /translation="METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSLDYVGNVD
                     RFGEIFPEVEQQEEIVVTAYYPDTVDVTVVEADLQARISELTDFMDLGELKIGTTALA
                     EEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMS
                     LFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNTG
                     MENIHVAAGDLLKGVEIEADVIVANILADILIHLTEDAYRLVKDEGYLIMSGIIKDKW
                     DMVRESAESAGFFLETHMVQGEWNACVFKKTKDISGVIGG"
     gene            14497..15240
                     /locus_tag="ACL8AS_001638"
     CDS             14497..15240
                     /locus_tag="ACL8AS_001638"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001188214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HGS1229464.1"
                     /translation="MQQYFVKGSAISPVTIEDKETSKHMFQVMRLKEEDEVTLVFDDG
                     IKRLARVLDMENRQFELVQELNDNVELPVQVTIASGFPKGDKLEFIAQKVTELGASQI
                     WAFPADWSVAKWDGKKLGKKVEKLEKIALGAAEQSKRNIVPSIKLFEKKADFLAQLDQ
                     FDSIIVAYEESAKEGEAAALLQAVSGLETGAKLLFIFGPEGGLSPAEIESFEAKGAVL
                     VGLGPRILRAETAPLYALSALSVLVELEK"
     gene            15251..17047
                     /gene="pepF"
                     /locus_tag="ACL8AS_001639"
     CDS             15251..17047
                     /gene="pepF"
                     /locus_tag="ACL8AS_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HGS1229465.1"
                     /translation="MEQKHRSEFPEKELWDLTALYQDREDFLRAIEKAREDINQFSRD
                     YKGNLHTFEDFEKAFAELEQIYIQMSHIGNYAFMPQTTDYSNDEFANIAQAGMEFETD
                     ASVALTFFDDALVVADEEVLDRLGELPHLTAAIRQAKIKKAHYLGADVEKALTNLGEV
                     FYSPQDIYTKMRAGDFEMADFEAHGKTYKNSFVTYENFYQNHEDAEVREKSFRSFSEG
                     LRKHQNTAAAAYLAQVKSEKLLADMKGYDSVFDYLLAEQEVDRVMFDRQIDLIMKDFA
                     PVAQRYLKHVAKVNGLEKMTFADWKLDLDSALNPEVTIDDAYDLVMKSVEPLGQEYCQ
                     EVARYQEERWVDFAANSGKDSGGYAADPYRVHPYVLMSWTGRLSDVYTLIHEIGHSGQ
                     FIFSDNHQSYFNAHMSTYYVEAPSTFNELLLSDYLENQSNDPRQKRFALAHRLTDTYF
                     HNFITHLLEAAFQRKVYTLIEEGETFGASKLNSIMKEVLTDFWGDAIEIDDDAALTWM
                     RQAHYYMGLYSYTYSAGLVISTAGYLHLKNSETGAEDWLNLLKSGGSKTPLESAMIIG
                     ADISTDKPLRDTIQFLSDTVDQIIAYSAELGE"
     gene            17294..17848
                     /locus_tag="ACL8AS_001640"
     CDS             17294..17848
                     /locus_tag="ACL8AS_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2785 domain-containing protein"
                     /protein_id="HGS1229466.1"
                     /translation="MYQDLLRKIAEEKPNYNQEEIQWLFDHLGNPSPEIRDDLSNQGL
                     HYLSKEKDTTDFSSQYGWVHAFAHGADLLTEVVCHPDFPINRIHEVFDILGQLFKRMS
                     IRFTDDEDWRLARVIYEPILQGKLEQEQVASWIKTVDFPIEEREDFYKFSNFRSCLVE
                     VYVQLDQRNSLQDDLKEAIQSFQY"
     gene            17959..18627
                     /locus_tag="ACL8AS_001641"
     CDS             17959..18627
                     /locus_tag="ACL8AS_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MIP/aquaporin family protein"
                     /protein_id="HGS1229467.1"
                     /translation="MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAI
                     VVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLGN
                     SGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
                     LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFL
                     GTEE"
BASE COUNT         5772 a         3143 c         4067 g         5756 t
ORIGIN      
        1 ataatcttta gacttgaatt tgattctgta ttcacgccct caatagacgg taaaataaga
       61 aaattgttta tatattgtct ccgtagtgtt attatacgaa ataaaagatt ttaggaaaag
      121 tcgttatatc atgctatacc tattctttgt ggtataattg caagaggttt aatccgataa
      181 tttataaaga gagaaagata ttcatgagag atttattatc taaaaaaagt cataggcaat
      241 tagaattatt agaattatta tttgaacata aacgttggtt tcatcgttct gaactagcag
      301 agttattaaa ttgtacagaa cgtgcagtca aagatgatct atcccatgtt aaatctgctt
      361 ttcctgactt gatttttcat tcttctacta atggtatacg cattattaat accgatgata
      421 gtgatattga aatggtttac catcatttct ttaaacattc aactcatttt tcgattttag
      481 aattcatctt ctttaatgaa ggttgtcaag ctgagagtat ttgtaaagaa ttttatatca
      541 gttcatcttc gctctatcgt attattagcc aaatcaataa agtgattaaa aggcaatttc
      601 aatttgaagt cagtctgacc cctgttcaaa tcattggaaa tgagagagac attcgttact
      661 tttttgcaca atatttttca gaaaaatatt atttcctaga atggccattt gaaaattttt
      721 catcagagcc actatctcaa ttgttagaat tggtttataa ggaaacaagc tttccaatga
      781 atttgtcaac gcatagaatg ctaaagttgc tcctagttac gaacctatat agaataaagt
      841 ttggtcattt tatggaagta gataaagatt cttttaacga ccaaagtttg gattttttaa
      901 tgcaggcaga aggaatagaa ggtgttgctc agagttttga atcagaatac aatatctctt
      961 tagatgaaga agttgtttgc caattatttg tgtcttactt tcaaaaaatg tttttcatag
     1021 atgaaagtct ctttatgaaa tgcgtaaaaa aggatagtta tgttgaaaaa tcttaccatc
     1081 tattgagtga ttttattgat cagatttcag tcaagtatca gattgaaatg gagaataagg
     1141 ataatctgat ttggcatctg cataataccg cacatctgta tcgtcaagag ttgtttactg
     1201 agtttatttt atttgatcaa aaagggaata caatcaggaa ctttcaaaat atttttccaa
     1261 aatttgtttc agatataaaa aaagagcttt ctcactattt agagactctt gaggtttgtt
     1321 ctagttcaat gatggtaaat catctatctt ataccttcat cactcatacc aaacatttgg
     1381 tgattaattt gctacaaaat cagcctaaac taaaggtttt agttatgagt aattttgatc
     1441 agtatcatgc aaaattcgtt gcagagacac tttcttatta ctgtagcaat aattttgaac
     1501 tggaagtttg gactgaatta gaattatcaa aggaatcttt agaagattca ccttatgata
     1561 tcattatttc taattttatt attcctccta ttgaaaataa gagactcatc tattcaaata
     1621 atataaacac ggtctcactc atatacttgt taaatgccat gatgtttatt cgattagatg
     1681 agtaaccaaa aataacaaaa aaacgctatt tcgcgtttga actgtacctc aaaagttaga
     1741 cagaaaaaat ctaatttttg gggtgttttt gttaagaaaa gaccttcaat catttaagca
     1801 aaatgtacat ctagatttat agccctctaa aactcttgct ttttttgtag aagatacgaa
     1861 aaaagccata aaaccaaggc ttttcctgtt ttatgtagat gtttacacat gaaaattgaa
     1921 gtattttcaa aagctaattg gagtgatttt attcatgatg ggataaatga tctggccaaa
     1981 aatgattgag aaatagttgc ttaaaaagca tttgcatgat actatatatt gaaaggaggt
     2041 gataatatgg tagaacaaag aaaatcaatt accatgaaag atgttgcttt agaagcagga
     2101 gttagtgttg gaactgtttc acgtgtaatt aataaagaaa aaggcattaa agaagtaact
     2161 ttaaggaaag ttcaaagggc tataaaaaca ttggactata tccctgataa ttatgctcga
     2221 ggtatgaaaa agaatagaac agaaactatc gctttgatta ttccgagcat atggcatcca
     2281 tttttttcgg agtttgccta tcatgttgag aaagagttat taaaatataa ttataaatta
     2341 tttatttgta acgctgatag cgattcacaa aatgaaatcg aatatatcga aatgttgaaa
     2401 caaaataaag tggatggaat tattggtatt acatattctg atattgacaa atatatttta
     2461 tctgatttac cgtttgtaag tatagataga catttttcgg aaaatgtatg ctatgttact
     2521 tcagcaaatt acaaaggagg acaaactgca gcagaggaac tggttagaag ggataataag
     2581 caccttgctt ttattggttc aattaatatg tatgagaatg agactatact cagaagtaaa
     2641 ggattcagag aaaaagctaa ggaattagga gtagatgtct ataattttga aatgaaagaa
     2701 cctttaataa atcctgaaga tcagataaga atttttttgc aatctcataa agaaattgat
     2761 ggtatattta caataaatga tatgatggct ctgagagtta ttagtgttat gaaagaactg
     2821 gggaaaatag cacctgatga ttaccagata attgggtttg atggtttaaa aacttctgtc
     2881 gatcaatctt atctagtgtc tacaatagtt caagatattg gtatgatggc aaaagaatct
     2941 gttgcaatga tactgaaaat gattaagcga gaagagattc tagaaaaacg aatcgtaatt
     3001 cccacatatt tttggggaga taaaacaaca aaaaaaattt aaaaagcgct tgacaattaa
     3061 tgaaagcgct gttataatat aatcaacaaa tgaaacgttt caaaaatagg ctagaagctt
     3121 gtttaaaaaa taaataaaaa atgaaacgtt tcaaaaaagg aggaaaatga tgcgtaaagg
     3181 tacaatgtta tctgttgttg cggggctatc gttagctata cttgcaggtt gtagtggagg
     3241 aactaactca aaacaagcga gttcttcaaa tgatattaaa gtctgggtac aattctctga
     3301 cgaaacaaat gaaggaaaag cttggcaaaa agttgttgat aactttaatc aatcaggaaa
     3361 aagtaagtac aaggttgtaa ctgagtatat tcctcgtagt ggtagtggtg gaggatatga
     3421 agacaaggtt aatgctgcta ttacgactaa tagtcttcca gatgttatta cccttgatgg
     3481 accaaatacg gcagcttatg caaaatctaa agtaattact ccgctagatg attatctaaa
     3541 agataataat atggatgatg ttttggacag tattaaacaa cagggaactt ataatgggaa
     3601 attctatgca tttggatttt ctgaatcgaa tgttggtgtt tattacaata aaaaaatgtt
     3661 caaagaggcc ggaattgcgg aatcagagct tccaacgcta gaaaagccat ggacatggga
     3721 cgaatttaat acgattgcta aaaaattgaa agatcattat aacaaaccag caattgattt
     3781 tcgtattaat tcaaacgatg aaatgttgcc atatgcttat atgccgttga tttggtcaaa
     3841 taatggttct gtcgtaaacg aagatggaac aaaggcagaa ggatacttca actccaaaga
     3901 gagtgtagaa gcagttcaat tcattcaaaa tcttgtaaaa gaaggctata caactgttag
     3961 tccagtcgaa aaaggttttg aaacaggaga gtatccaatg cttttgagtg gttcttggac
     4021 gattgctgac atgaatacaa actacaaaga tattgatttt ggtatccttc cttacccagt
     4081 atctagtaag acgaaaaaat tagtatcccc ttcaggtagt tggcaattag ctgtgacgac
     4141 aaaatctgat aaaaaagagg ccgcatctga atttgttaaa tttgctacaa atacagaatc
     4201 aagtgaaatt attagcttgg ggaattcggt ccttccaatt cgtaaatcta caattgaaaa
     4261 tatcaaagat aaagtatccg aaccaatgcg tttcttgatg gaacaaaatt caaaaacagc
     4321 tcatgctcgc ccagttgttg tagcatatcc tcaggtttct cgagcttttc aacaagcaat
     4381 gcaagatatt agctattatg aagaaaatcc aaatgtgcaa aaagtcttgg atactcgtac
     4441 aaaagaaatg caaactgcta ttgatcagtc actcaaataa tctgtaaaaa agaaggtgga
     4501 aggaaaatgt ttggaactac cttccccttt cttgttaata gcctagtttg atatatatga
     4561 ttaaaggaga tggatatgag taaagaaact gttgtggata caaaaagacg tgaaaaaata
     4621 aaggataaca tattaggtta tagtttttta gctccagctt taattttatt aggtatcttt
     4681 ttagtaattc cagttggaat ggtcatttat tacgctttta cagattatta tttgttgaca
     4741 ccagatgaaa gaaaatttgt tggacttgaa aattttattc gattaacaaa agatccgatt
     4801 ttcttaaaga gcttcttgaa tactttgaaa tttgttgttt ggattattcc agttcaattg
     4861 ggagcggcct taggaatggc tttgattgtc aataaaaagc gaaaaggaaa tatgtttttt
     4921 aaagtggctt tttttgctcc agttgtcatg tccttggtag ttatttctat tctttggctt
     4981 tatcttttaa atccaaatag tggcttattg aatgctattt taaataaggt aggtattgct
     5041 tctcaacctt tcttgactag tcctaaacaa gctatgtatg caattgtttt tgtttctgct
     5101 tggcagggtg caggttatca gatgctttta tttttaggag gaatgcagaa tattccacaa
     5161 gatgtctatg aagctgctga attagatgga ttctcaaaat gggctcagtt tcgttatatc
     5221 acgatgcccc tactaaaacc aacagccctg tttgtattgt taacaacttt aatttctgct
     5281 tttaagctga ttgtacaacc aatggttatg acgcaaggtg ggccattaaa ctcaacaatt
     5341 actatggtgt actatattta tcaacaaggt tttactgatc gtcttgtagg atattctagc
     5401 tcaatcgctt tagtatttac aacgttaatt ggtatgatta gcttagtaca acgtcgcgtt
     5461 ctgaaggagg atgactaaga tgaaacgatt taaaccaaca acaatcttag aatatattct
     5521 gttaacttta ttggcaggac tcttcctttt tcctatggtt tggatggtag tttcagctat
     5581 gaagccagaa gcggatgttt ataaaaattt gactagttgg caagccttct taccaagttt
     5641 aaatcccgct gattggttta aaccttatca ggaagtattt gagcgcttta gtatttttac
     5701 atatctaggg aacagcattt tttatgctgg aacgtttgct attggttcta ttattgtcaa
     5761 tgcactggcc ggtttcgctt ttgcaaaagt caatttttca ggtaagaaaa ttttatttgg
     5821 tttcttactt gctttactta ttattccagt ggaaactgtg ttaattccac aatttaccat
     5881 tatcaattcc ttaggtttgg tcaataatcg tcttgcagtt attattccag gattggcgag
     5941 tgtatttaat atttacttat ttaggaattt ctttattgca attccagaag agattcttga
     6001 gtctgcaaag atggacggag caagtatcgt tagaattttc tttagaatta tgcttccaat
     6061 gtctaaacct gcagttgcta cagttggtgt tttatcattt atttcaagct ggaatgatta
     6121 tatctggcca ttgatggttt tgacagattc ttctaaattt tcaatgcagg ttgcaattac
     6181 aactattaat acaactcaac cagtttatat caatcaggta atggctgtat taactatttc
     6241 aacgattccg ttgattttgg tctatgtagt cgctcagaaa tatattgttc aaggtctggg
     6301 tggttccgga actggaataa aataggatat acttatgata aataaaacat ttacagtaga
     6361 aaaagccaat cgttttatag cagaaaataa acatctcgtt aatactcaat ataagcctga
     6421 agaacatttt tcagctgaga ttggttggat caatgatcca aatggatttg tctattttcg
     6481 tggagaatac catctctttt atcaattcta tccatatgat agtgtttggg ggcctatgca
     6541 ctggggacat gctaaaagta aggacttggt gacttgggag cacttgccag tggcacttgc
     6601 tcctgaccaa gattatgacc gaaatggttg tttctcaggc tctgccattg tcaaggatga
     6661 tcgcctctgg ctcatgtaca ctggacatat cgaagaagaa accggtgtcc gccaagtgca
     6721 aaatatggca ttttcagatg acgggattca ctttgaaaag atttcccaaa atccagttgc
     6781 aactggagca gacttgccag atgagttgat tgctgctgat ttccgtgatc caaaactctt
     6841 tgaaaaagat ggacgctatt actccgtagt agctaccaaa cacaaggata atgtgggctg
     6901 tatcgttcta ctagggtccg ataacctagt agaatggcag ttcgaatcca tctttttaaa
     6961 aggggtagaa caccaaggct ttatgtggga atgcccagat tacttcgagt tagatgggaa
     7021 agattgcctt attatgtcac ccatgcgtta tcagcgtgag ggagactcat atcataacat
     7081 caactcatcg cttttgttca cgggtaaggt agagtgggga gaaaaatgtt ttatcccaga
     7141 atcagttcaa gaaattgatc atggccaaga cttctatgcg cctcaaacat tgttggacga
     7201 tcaaaatcgt cgtatcctga ttgcttggat gcagacatgg gggcgtaccc ttccaaccca
     7261 tgaccaagaa cacaaatggg catgtgccat gactttacct agaattctaa gattggaaga
     7321 tggcaaacta agacaattcc ctgttaaaaa aggccaatat caaatccaaa tagataaaga
     7381 ttgtcattac cacttaggaa atgatataga ttatcttgaa tttggttatg acagtaatgc
     7441 gcagcaagtt tacattgatc gtagccatct tattcaaaaa attctaggtg aagaagaaca
     7501 ggacactagt cgacggtatg tagatattga agctaaagaa ttggaagttg ttctagataa
     7561 aaattccatc gagatttttg tcaatcaagg tgaagcaagc ttgactgcaa cttattactt
     7621 aacggtgcca gctgagctat cacgaattga ttaaaaatta agttatttct cctaaagaaa
     7681 aagttctctt tctaaaatag tggaaagagg actttttgtg ttttgggtat ataagcttag
     7741 tttatggtat ttgtaaaatt ggtgttggat tatgatttaa gctagttttc taaagaattt
     7801 gaaaaaaatt ttatttaagc aaaaaaaaac cttggttcca agacttttcc tgttgtattt
     7861 agatgccccc tacagggatc gaacctgtga cccacggatt aagagtccgc tgctctgcca
     7921 gctgagctaa ggaggcaaag aaaaaagctg tattggtgcc gaaacttcac ggtttgtatt
     7981 gaacccgcgc aattaagcag gtgggcaact cgctctaact gaagctgttt ccgtgtgaga
     8041 cggcctacat gctgttagaa gacttttgtt tccctaataa tacaaaaaat agtcggtcaa
     8101 cacttaagtg tgaagtcgta caccacagcg tttctatatt tatatgatac cactttttta
     8161 aaaaaaatca agaggaaagt gcaatttttt gaaaaggatt tcagattttt cgcaaatggt
     8221 cgatagcttc ctttctttga gccaaagccc gttcatattt accagtatct tctgcttgga
     8281 aatagtgatg attacgaatt ttttctggca gatagtcttg ctttacccaa tttccaggat
     8341 agttgtgtgg atagagatag tcttgggcat tccccagttc cttgcttcca ctgtagtgcc
     8401 catcacgtag gtgtcgcgga ataggcaagt gccctgatgt tttgaggtca gcaagtgcct
     8461 tatccatagc tacataggct gagttggatt ttggagaaag ggccaaatca atcacgacat
     8521 tggcaatgag aatgcgggct tcggggaaac caatcctttg tgcagcatcc agagcagtca
     8581 cggtatgaat ctgggcctca ggattggcta agccgatatc ttcataggcg ataacagtca
     8641 agcgacgagc gagactaggc agatccccag cctcaatcaa gcgggcagta tagtggagac
     8701 tggcatccac atctgagcca cgaatagact tttgcagggc agatagaaca tcatagtgac
     8761 cgtctccatc cttgtccata gtgatgtagc ttctctgaag actattttcc atgatgtcta
     8821 aggtgatgtg gcgaatgccc tcgtcattct caggggtaga tagaacagcc aagtccagtg
     8881 agttaaaggc agagcgaagg tctccgtttg tagaggttgc gatgaaatcc agcgcatcct
     8941 catctagttc tattggaaaa tcaaaaccac gttcagggtt acttagagct atctgcaggg
     9001 cctctttgac gtcttggtta gacagaggtt ccaactcgaa aatttgaaca cggctacgaa
     9061 tggcaggagt gacagagaag aaaggatttt cagtcgttgc tccaatcatg atgaccagtc
     9121 cactttccaa gagaggcaag aggaagtctt gcttggtctt atctagtcga tgaatttcgt
     9181 ctagcaatag gacgagacca ccagaaaatt tagcttcttc cgagatttct tgcagtcgct
     9241 ttttactatc aactgtcgca ttgaaagttc gaaaggcata cttggtcgtt ccagcgatgg
     9301 cagaggcaat actggttttg ccgattcccg gagggccata tagaatcatg gaggacaggc
     9361 ggttggcttc caccatgcgg cggatgattt ttccaggtcc gaccagatgc tcctgaccga
     9421 tgacctggtc gatggtttta gggcgcatgc gaagcgcgag attgtctggc atagcagtcc
     9481 tttctaacgt ggatttgagt agaatgactc atctactata tcttactatg tccattctag
     9541 cctattagtt gtgatatttc aatggttttg taataatcag ggagtgagat agaatctttt
     9601 ttactattta atttaatgag gagaggtatc agcatgagag atttgatttt ccttaaagct
     9661 caaaatagga tagttgagcc taaagaagtg gaagtgctga cttgagaaat aatattgcta
     9721 aatgtcattg tatgaactat aatgaaaaga gaggtgataa gcaatggaaa tgatggacca
     9781 agtcaggaaa ttttgatttt tacaaaacaa attcgtcatt ggattcttag tgatcaagtt
     9841 atttcaggga aaagaaaact tttcttccgg gaagatactc caaaagagat tttagatttg
     9901 tacgaaaaca ttaaatctaa acttgatttt gcttaccaat aagtttattc taataatggg
     9961 ttgaaaaaat atgaaaaata gaataattga tgtttttgaa gtagtaaatc gcatccttgt
    10021 aataactgtt gaaaatcctg atttcgaaga cttgagagtt aatcatactc aatgaaaatc
    10081 aaagagcaaa ctaggaaact agccgcaggc tgtacttgag tacggtaagg cgacgttgac
    10141 gtggtttgaa tttgattttc gaagagtatc agtttgtaaa aattggagat aaaaaatata
    10201 gagtacgcag tgttcctatg attcattcaa ctccgcctca atctgtctta gatcgagata
    10261 cttttacaat tgactataca gatgatgaat tgctcgataa agaagcagtt tttactactc
    10321 attagaaaaa taggtctgaa taaattggct tcccttagaa ccacatctag gggcttttat
    10381 gtataataga ataataagta tcactccttt acaatacgtg taacacgtgt tataatggtg
    10441 ttgtcaggag gtaaaagcgc tatgcctatg acacaaaaag agatggttaa actccttacg
    10501 gcccatggtt ggataaagac tagaggcggt aaaggctccc atattaaaat ggagaagcaa
    10561 ggggaaagac ttatcacaat ccctcatggt gagctgaata agtacactga aagagggata
    10621 agaaagcaag ctgggttgta aaattcagcc cctgtttttt gatatggagg tagtgaaatg
    10681 ttagttacgt atccagcttt attttattat gacgacacag acggaacaga agcgacttat
    10741 tttgtccatt tcccagattt tgaatactca gctacacaag gagaggggat ttctgaggct
    10801 ttggctatgg ggtcggagtg gctagggata actgttgcag atttgataga gagtgatgga
    10861 gagttacctc agccatcaga tatcaatagc ttgtctttaa ttgataatga tccttttaaa
    10921 gatgatgaag atttcgtgtc aacctatgac cttgataaat cttttatttc tatggtatct
    10981 gttgatgtat cagaatacct aggaagtcag gaacccatta aaaagacttt gaccatacca
    11041 aaatgggcag ataagttggg acgagaaatg ggacttaact tttctcagac tttgacagac
    11101 gctattgcag ataagaaagt tcaagcctaa gattaagcgt ggtatcgtgg taatagtcaa
    11161 taaaaaagca cgtccacttg tgctagttac tcgcctattg attttataga tttattagcc
    11221 ctttcgaggg ctttttatat tgatttttat gagaaatgaa gaaatcagac ttttaagaaa
    11281 atcactgata tcaagggttt aaatgaggta atatggtata attaggacat aaaataattt
    11341 tgtggtaaga tggtagtatc tattttagca tatttccgag caatcggggc gattaaagag
    11401 tcgcatagaa agaggacaaa atggcaacat acggattttt agatgtttta gaggaagagt
    11461 tggacaagaa ctttcccttt gactttgaga ttagctggga caaacgcaac catgcggtag
    11521 aagtgagttt tctattggaa gcgcaaaatg ctgcaggtgt ggagatggtg gatgaagacg
    11581 gagaggtttc atcagatgac attctttttg aggaagcggt ccttttctac aatcctgcca
    11641 agtcaaccgt caatgcagaa gactatttaa cggttatccc ttatctacct aaaaaaggat
    11701 tttctcgcga gtttttagct tattttgcca ttttcctcaa agatactgct gaggttgggc
    11761 tagataccct catggacttt ttggaagatc cagaagcaga ggaatttgtc atggaatgga
    11821 accaagaagt ctttgaagaa ggaaaagttg gtttggaaga gggagaattt tatccttatc
    11881 caagatacta ggagttggtt ggaggtgtta tgaagaaaat tgggacttat ttggtttatg
    11941 tgctagcttt tgtctttatt atgctagctt ttgcttgtgg aacaatcgca tttgcagagt
    12001 tggggtattc cgcagtttta gcctttactt ttggttatgc cttcgctctt ctaagcatgt
    12061 atttaatctt tattcttcat gagctgggtc atgctttttg tggctacttg acaggctatc
    12121 ggctggtggc ttttggatta ggacatttta ttttgaccaa aaagtcaggc aggtttcatc
    12181 ttagtagaac agccattctg aaaaatgttg gtgctcaata cattggttta aaagaggatg
    12241 aaagcgatca aagaatcatc ctgatgcttt caggaggctt gatggttcat ctcggcttga
    12301 tattattggc gatagtgttt ggatttttga caagaagctg gtattttgca gggacttgga
    12361 tttttcttaa tttatctttc ttcctaaata acattttgcc agtcgacatc accgatggag
    12421 caaaaatttg ggaattacta caacaccctg aaaataccaa atacgcctac ctggtattga
    12481 gacattctgc tcaaactttg ctggctcctc aagaatatga tttgaaagac tttgttcaag
    12541 cagttcctga ggatgcacga gggagttttg cggatggtgt attaggtatg caaggtgaag
    12601 tttccatttt ggaagggaag gaagaagtag ctaaacagca gtttcaagca ttacttgaga
    12661 ggacaactac tccgatgatg cagacagttg cccaactatc cctgcttcat atcgccttgt
    12721 tggaaggaga ttttgagcaa gcggagcaat atgctagtat tcgacaggtc aaatcgtttc
    12781 tgtctctcaa actgtccaat cttcaagtga tacaagcttg gtatcaattt aaggtaaaga
    12841 aagatgtaga tcgaactcgt aaggctctca agattgctag acagaaaatg gatagtagtc
    12901 gaatgttgag ggacgagaaa cgctattatg aaaacttgtt agcagagctg gaaaaggaaa
    12961 tgttagaagg aactgaagat ggaactagaa atttctgatt tcccaggctg taagattgct
    13021 ttgttttgtg gggataagct cttgactatc ttacgtgatg ataaggcaag tattccctgg
    13081 gccaatatgt gggaactgcc aggtggtgga cgtgaaggtg atgaaagtcc ttttgagtgt
    13141 gtagcgcgtg aagtttatga agaactgggc attcatctga ctgaagattg tctgctttgg
    13201 agtaaggttt acccaagtat gctttttgca gacaaacagt ccgtttttct agttggtcag
    13261 ttgacacaga accagtttga cagtatcgta tttggagatg aaggacaggg ctatcagctg
    13321 atgaatgttg aggaatttct tagttccagt caagttgtgc ctcagttgca agagagatta
    13381 aaagattatt taaaagtaag tgattagaaa ggatggttca gttaaatttc taaactgaac
    13441 ccgccctaaa cactgtgcca aaaagataaa cttctcttag acacaaacgt cttcagagaa
    13501 tttcctattt tggttttgtg ttttacgggc ttggtatctt aatgatggaa acatggcaag
    13561 agttaaaagt tacagtgaag cgtgagggag aggagttggt ttccaatctc ttgattgagc
    13621 tgggagcgca aggtgttgcg attgaagaca gtctggacta tgtgggaaat gttgaccgct
    13681 tcggcgagat tttcccagag gtcgagcagc aagaagaaat cgtagtgaca gcctactacc
    13741 ctgacacggt ggatgtgaca gtggttgagg cggacttgca ggctcgcata tcagaattga
    13801 cggattttat ggatttggga gagttaaaaa taggcacgac tgccttggct gaggaagact
    13861 gggctgacaa ctggaagaag tattatgaac cggcacgcat cacccatgac ctgaccatcg
    13921 taccgtcatg gacggactat gaggcaacag caggagaaaa gattatcaag ctggatcctg
    13981 gtatggcctt tgggacaggg acccacccaa caaccaagat gagcctcttt gccttggaac
    14041 aggttcttcg tggtggcgaa acagtgctag atgtagggac tggttcaggg gttctttcta
    14101 ttgcaagctc actcctaggt gccaaggaga ttttcgccta tgacctggat gatgtggcgg
    14161 ttcgtgtcgc tcaggaaaat attgagctca acactggtat ggaaaatatc catgtagcag
    14221 caggagactt gcttaaggga gttgagattg aagcagatgt catcgtggct aatatcttgg
    14281 cggatattct cattcatctg acggaggatg cttatcgctt ggtaaaggat gaaggctacc
    14341 tcatcatgag tggcattatc aaggacaagt gggacatggt gcgcgagtcg gctgagtcag
    14401 ctggattttt ccttgaaacc cacatggttc aaggggaatg gaatgcctgt gtctttaaga
    14461 aaaccaagga tatttctggt gtgattggag gctaggatgc aacagtattt tgtcaaaggc
    14521 agtgctatct ctcctgtcac catcgaggac aaggaaacca gtaagcatat gtttcaggtt
    14581 atgcgcttga aagaagagga tgaggttacc ttagtctttg atgatggcat caagcgcttg
    14641 gcgcgcgtgc tggatatgga aaatcgtcag tttgagttgg tccaagaatt aaatgacaat
    14701 gtggaactac cagtccaagt gaccatcgca tctggatttc ccaagggaga caagctggag
    14761 ttcatcgctc aaaaagtaac cgaactgggt gctagccaaa tctgggcctt tcctgcagac
    14821 tggtcagttg ccaagtggga tggcaagaaa ttgggtaaaa aagttgaaaa actagaaaaa
    14881 attgcccttg gagcagccga gcaaagcaag cgtaatattg taccaagtat taaacttttc
    14941 gagaaaaaag cagattttct agctcagctg gaccagtttg actctatcat agtagcctat
    15001 gaagaatcag ctaaagaagg agaagccgct gcgctcttac aagcggtctc tggtcttgaa
    15061 acaggagcca aactgctctt tatctttgga ccagaaggcg gtctctcacc tgcagaaatc
    15121 gaaagttttg aagctaaggg agcagttttg gtaggcctag gtcctcgtat tttgcgagca
    15181 gaaacagcac cgctttacgc cttatcagcc cttagtgttt tagtagaatt agagaaataa
    15241 gaggaagaaa atggaacaaa aacaccgttc agaatttcca gagaaggaac tctgggactt
    15301 aacagcccta taccaagacc gtgaggattt cttgcgtgca atcgagaaag ctcgcgaaga
    15361 catcaaccaa tttagccgtg actataaggg caatcttcac acttttgagg atttcgagaa
    15421 ggcctttgcg gaattggaac agatctacat tcagatgagc catattggca actatgcttt
    15481 tatgcctcag acgacggact atagcaatga cgaatttgcc aatattgccc aagctgggat
    15541 ggaatttgaa acagatgcca gcgtagcctt gaccttcttt gacgatgcct tggtggtagc
    15601 agacgaggaa gtcttggacc gtttgggtga attgcctcac ttgacggcag ctattcgtca
    15661 ggccaaaatc aaaaaagccc actatctagg ggcagatgtg gagaaggcct tgacaaatct
    15721 cggtgaagtt ttctacagtc cgcaggacat ttatactaag atgcgagctg gggattttga
    15781 aatggctgac tttgaagccc atggcaagac ctacaaaaac agctttgtga cctatgagaa
    15841 tttctaccaa aaccatgagg atgctgaggt tcgtgagaaa tccttccgtt ccttctcaga
    15901 gggacttcgt aagcaccaaa atacggctgc agcagcctat ctggctcagg tcaagtctga
    15961 aaaactcttg gctgatatga agggatacga ctctgtcttt gactatcttc tagctgaaca
    16021 agaagtggac cgtgtcatgt ttgaccgcca gattgacctc atcatgaagg actttgcacc
    16081 agtcgctcag agatacctca agcatgttgc caaggtaaat ggtcttgaaa agatgacctt
    16141 tgcagactgg aaattggact tggacagcgc cctgaatcct gaagtgacta ttgacgatgc
    16201 ctatgatttg gtcatgaagt cggtagaacc tttggggcaa gaatattgtc aggaagttgc
    16261 tcgttaccaa gaagagcgct gggtggactt tgctgctaac agtggcaagg attccggtgg
    16321 ttatgcggcg gacccatatc gcgtacaccc ttatgtactc atgagctgga caggccgttt
    16381 gagcgatgtc tataccttga ttcatgaaat cgggcattct ggtcaattca tcttttcaga
    16441 caatcaccaa agctatttca acgcccacat gtcgacctat tatgttgaag caccgtcaac
    16501 cttcaatgaa ttgctactca gtgattactt agagaaccag tctaatgacc cacgtcaaaa
    16561 acgcttcgct ctggctcatc gcttgacaga cacctacttc cataatttca tcacccacct
    16621 cttggaagcc gccttccagc gtaaggtgta tacattgatt gaagaagggg agacctttgg
    16681 agcaagcaag ctcaacagca ttatgaagga agttttgaca gatttttggg gcgatgccat
    16741 tgaaatcgac gacgatgcag ctttgacttg gatgcgccaa gctcactact atatgggctt
    16801 gtatagttac acttactctg ctggtcttgt catctcgaca gctggttacc ttcatcttaa
    16861 aaactcagaa actggagctg aagactggct caatctcctc aaatcaggtg gtagcaagac
    16921 accacttgag tcagccatga ttatcggtgc tgatatttca acagacaaac cactccgtga
    16981 taccatccaa ttcttgtctg acacagttga ccagattatc gcctacagtg ctgagttggg
    17041 ggagtaaggg gaatagaaaa attttctaga atgatgttta tgggcttgtt aagcgtcatt
    17101 ctatttgtct tagttgtagc tattttcaaa aatgtcgttg aaggtcgtga tgttaaattt
    17161 gaacttactg tagaactggt attgatagtt atttacgtca ttttatatca gattgtattt
    17221 aattgagaat tcaatattga gtcatttaag actgcctttt tgaacagttg ctagaaatgt
    17281 agaggtattg accatgtatc aagatttact aagaaaaata gcagaagaaa aaccaaatta
    17341 taaccaggaa gaaatccagt ggttgtttga tcatttggga aatccttctc cagaaattcg
    17401 tgatgacctt tcaaatcaag gcttgcacta tctttcaaaa gaaaaggata caacagattt
    17461 ctcaagtcag tatggttggg ttcatgcttt tgcacatgga gccgatttac tgacagaggt
    17521 ggtttgtcat ccagactttc ctataaacag aattcatgaa gtatttgaca tacttggcca
    17581 actatttaaa agaatgtcga ttcgctttac agatgatgag gattggcgtt tagcaagagt
    17641 gatctatgaa cctattttac aagggaagtt ggagcaagaa caagtagctt cttggataaa
    17701 aactgttgat tttccgatag aagaaaggga ggatttttac aaattttcca actttagatc
    17761 ctgtctggtg gaagtctatg tccaacttga ccagagaaat agtttacaag atgacctgaa
    17821 agaagctatc cagtcttttc aatactagag attagctaat agttctatga ttttcaaaaa
    17881 atttccaatc aattttcttg aaaccctttc ctacttttga tagactagta tctagttttt
    17941 gaaaaaagga gaaagaaaat gaaaaaattt gttgctgagt taatcggtac gttcatgctt
    18001 gtgttcgttg ggacaggagc tgttgttttt ggaaatggtc ttgatggcct tggtcacctt
    18061 ggaatcgcct ttgcctttgg tttggcaatc gtggtggcag cctactcaat cggaactgtt
    18121 tcaggtgctc acttgaaccc ggctgtttcg attgctatgt ttgtaaacaa acgtttgtca
    18181 tcttcagaac ttgtaaacta catccttggt caggttgttg gagctttcat cgcttctggc
    18241 gcagtcttct tcctcttggg taattcaggt atgtcaactg ctagtcttgg tgaaaatgcc
    18301 ttggcaaacg gtgtcactgt ctttggtggt ttcttgtttg aagtcatcgc aactttcttg
    18361 tttgtcttgg ttatcatgac tgtgacttca gaaagcaagg gcaatggcgc gattgctggt
    18421 ttggtaatcg gtttgtcatt gatggcgatg attcttgtcg gattgaagat tactggactt
    18481 tcagtaaacc cagctcgtag cttggcacca gctgtcttgg taggcggcgc agcccttcaa
    18541 caagtttgga ttttcatcct tgcaccaatc gctggtggag ttcttgcagc ccttgttgca
    18601 aaaaatttcc ttggaacaga agaataattg aaactcaaaa agccttgctc ctcatcttga
    18661 ggaacagggc tttttcgtat gatactcttc gaaaatctct tcaaaccacg tcagcttcac
    18721 cttgccgtag gtatggtt
//
LOCUS       DBERMM010000039        18614 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.039, whole genome shotgun sequence.
ACCESSION   DBERMM010000039 DBERMM010000000
VERSION     DBERMM010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 18614)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18614)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18614
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.039"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(112..387)
                     /locus_tag="ACL8AS_001642"
     CDS             complement(112..387)
                     /locus_tag="ACL8AS_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HGS1229468.1"
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQ
                     LIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK"
     gene            complement(493..1332)
                     /locus_tag="ACL8AS_001643"
     CDS             complement(493..1332)
                     /locus_tag="ACL8AS_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HGS1229469.1"
                     /translation="MTKIKIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLK
                     EEGKFLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGQILAIHMSHALSGTVEAARQ
                     GASLSTADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILSHVEEVKNHTELYIGV
                     STLENLVKGGRIGRVTGLLSSLLNIRVVMQMKDHELQPMVKGRGTKTFKKWLDELITS
                     LSERAVAEIGISYSGSDDWAKEMKESLQAYVEKPISVLETGSIIQTHTGENAWAILIR
                     YHS"
     gene            1474..2322
                     /locus_tag="ACL8AS_001644"
     CDS             1474..2322
                     /locus_tag="ACL8AS_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HGS1229470.1"
                     /translation="MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITF
                     YLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSAWLAFFEHIPLHIDLQ
                     GDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCIL
                     MLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDL
                     GRGVTFISGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEG
                     FTFEKE"
     gene            complement(2415..3332)
                     /locus_tag="ACL8AS_001645"
     CDS             complement(2415..3332)
                     /locus_tag="ACL8AS_001645"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003919 - FMN adenylyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HGS1229471.1"
                     /translation="MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAA
                     RKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQF
                     ASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKG
                     KISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYM
                     PADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLD
                     RIRDMTKFDSVDQLVDQLKADEEVTRNWY"
     gene            3809..3958
                     /locus_tag="ACL8AS_001646"
                     /pseudo
     CDS             3809..3958
                     /locus_tag="ACL8AS_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family protein"
     gene            complement(4178..4471)
                     /gene="rpmA"
                     /locus_tag="ACL8AS_001647"
     CDS             complement(4178..4471)
                     /gene="rpmA"
                     /locus_tag="ACL8AS_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HGS1229472.1"
                     /translation="MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTG
                     GSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK"
     gene            complement(4488..4832)
                     /locus_tag="ACL8AS_001648"
     CDS             complement(4488..4832)
                     /locus_tag="ACL8AS_001648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HGS1229473.1"
                     /translation="MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINF
                     INSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENY
                     SEFVQTRVITEN"
     gene            complement(4848..5162)
                     /gene="rplU"
                     /locus_tag="ACL8AS_001649"
     CDS             complement(4848..5162)
                     /gene="rplU"
                     /locus_tag="ACL8AS_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HGS1229474.1"
                     /translation="MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVG
                     GENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAI
                     NA"
     misc_feature    complement(5198..5285)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00559"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L21 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00559"
     gene            complement(5350..6048)
                     /locus_tag="ACL8AS_001650"
     CDS             complement(5350..6048)
                     /locus_tag="ACL8AS_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YoaK family protein"
                     /protein_id="HGS1229475.1"
                     /translation="MGGKMRLLPIRKISRQSKRLALFLTFCAGYVDAYTFIVRGNTLV
                     AGQTGNVVFLSVELIKNNVSDVRDKVLTLLAFMMGVFLLTIYKEKLRIVKKPILSLIP
                     LAILSIIIAFVPQTVDNIYLVPPLAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLA
                     FGDYFRTKHTPFLREGFIFVSLLSSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLS
                     MLFASWQKKVKEKA"
     gene            6450..6749
                     /locus_tag="ACL8AS_001651"
     CDS             6450..6749
                     /locus_tag="ACL8AS_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HGS1229476.1"
                     /translation="MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLT
                     GDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF"
     gene            complement(7149..8123)
                     /gene="pta"
                     /locus_tag="ACL8AS_001652"
     CDS             complement(7149..8123)
                     /gene="pta"
                     /locus_tag="ACL8AS_001652"
                     /EC_number="2.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008959 - phosphate acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006086 - acetyl-CoA biosynthetic process
                     from pyruvate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="HGS1229477.1"
                     /translation="MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPV
                     LLGNPEKIKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVE
                     DVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTER
                     YLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVE
                     ATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYK
                     MAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ"
     gene            complement(8167..9063)
                     /locus_tag="ACL8AS_001653"
     CDS             complement(8167..9063)
                     /locus_tag="ACL8AS_001653"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HGS1229478.1"
                     /translation="MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQ
                     NATYLLDVGDYVTIYIPAEEGFETLEAIEHPLDILYEDDHFLVLNKPYGVASIPSVNH
                     SNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIE
                     KRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLV
                     YIHLHTGRTHQIRVHFSYIGFPLLGDDLYGGSLEDGIQRQALHCHYLSFYHPFLEQDL
                     QLESPLPDDFSNLITQLSTNTL"
     gene            complement(9060..9878)
                     /locus_tag="ACL8AS_001654"
     CDS             complement(9060..9878)
                     /locus_tag="ACL8AS_001654"
                     /EC_number="2.7.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003951 - NAD+ kinase activity [Evidence
                     IEA];
                     GO_process: GO:0006741 - NADP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD kinase"
                     /protein_id="HGS1229479.1"
                     /translation="MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIV
                     ISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGAR
                     VSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVST
                     PTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRN
                     DYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE"
     gene            complement(9862..10533)
                     /locus_tag="ACL8AS_001655"
     CDS             complement(9862..10533)
                     /locus_tag="ACL8AS_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0015969 - guanosine tetraphosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HGS1229480.1"
                     /translation="MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTG
                     RVKPIESIKEKMARRSITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRII
                     QERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYK
                     YQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDT
                     DEEYR"
     gene            10661..11230
                     /locus_tag="ACL8AS_001656"
     CDS             10661..11230
                     /locus_tag="ACL8AS_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CYTH domain-containing protein"
                     /protein_id="HGS1229481.1"
                     /translation="MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTLDFEL
                     REKKVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDAENYLSKEELPQGLVLDEL
                     AKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDMTDYELELEVENHEQGKQD
                     FRQFLEKNQISYQKAPSKLVRFVKSMKNS"
     gene            11343..12302
                     /locus_tag="ACL8AS_001657"
     CDS             11343..12302
                     /locus_tag="ACL8AS_001657"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HGS1229482.1"
                     /translation="MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQ
                     VNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDR
                     IACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD
                     KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKA
                     ILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDS
                     VATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK"
     gene            12312..13427
                     /locus_tag="ACL8AS_001658"
     CDS             12312..13427
                     /locus_tag="ACL8AS_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase family protein"
                     /protein_id="HGS1229483.1"
                     /translation="MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKL
                     LREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVL
                     ETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFANNETGNLLPIAEI
                     GQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFD
                     SYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQ
                     YYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLKAMH
                     GANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG"
     gene            13432..13779
                     /locus_tag="ACL8AS_001659"
     CDS             13432..13779
                     /locus_tag="ACL8AS_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1831 domain-containing protein"
                     /protein_id="HGS1229484.1"
                     /translation="MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTR
                     LLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMD
                     SLVERGVFTKSER"
     gene            13787..14002
                     /locus_tag="ACL8AS_001660"
     CDS             13787..14002
                     /locus_tag="ACL8AS_001660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HGS1229485.1"
                     /translation="MFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLT
                     FRGKKVYQGLVGDLYRFLSHADFLHQN"
     gene            14085..14726
                     /locus_tag="ACL8AS_001661"
     CDS             14085..14726
                     /locus_tag="ACL8AS_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HGS1229486.1"
                     /translation="MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIG
                     IDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLH
                     YRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSV
                     KSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED"
     gene            14744..15433
                     /locus_tag="ACL8AS_001662"
     CDS             14744..15433
                     /locus_tag="ACL8AS_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HGS1229487.1"
                     /translation="MKKPVIGITGNEKAHPDDDIMMSYAAKGFVEGVKDAGGIPIILP
                     IGDQEMACHYISLIDKLILTGGQNVDPKFYGEPKTIDSDDYHLQRDIFELALIKEAIK
                     QKKPIFSVCRGTQLFNVAMGGTLYQDIEDHWQDSSVEYTTQRLVTEPDTVLQEIYGEI
                     SHINSFHHQSIKDLAPNLKVVAHDPKDGIIEAVMSTDDVAFLGVQWHPELLFENRPKD
                     KKLFDYVVNEL"
     gene            complement(15430..16110)
                     /gene="radC"
                     /locus_tag="ACL8AS_001663"
     CDS             complement(15430..16110)
                     /gene="radC"
                     /locus_tag="ACL8AS_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000286923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HGS1229488.1"
                     /translation="MYSISFQEDSLLPRERLAKEGVEALSNQELLAILLRTGTRQASV
                     FEIAQKVLNNLSSLTDLKKMTLQELQSLSGIGRVKAIELQAMIELGHRIHKHETLEME
                     SILSSQKLAKKMQQELGDKKQEHLVALYLNTQNQIIHQQTIFIGSVTRSIAEPREILH
                     YAIKHMATSLILVHNHPSGAVAPSQNDDHVTKLVKEACELMGIVLLDHLIVSHSNYFS
                     YREKTDLI"
     gene            complement(16153..18444)
                     /gene="pcrA"
                     /locus_tag="ACL8AS_001664"
     CDS             complement(16153..18444)
                     /gene="pcrA"
                     /locus_tag="ACL8AS_001664"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000992850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_process: GO:0006268 - DNA unwinding involved in DNA
                     replication [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase PcrA"
                     /protein_id="HGS1229489.1"
                     /translation="MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYL
                     IDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHI
                     GYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA
                     GDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVD
                     EYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVL
                     LEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYRADDELDEAVFVART
                     IDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIA
                     YLNLIANLSDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKG
                     KAAQSIWDFANMMLDLREQLDHLSITELVESVLEKTGYVDILNTQATLESKARVENIE
                     EFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMTLHAAKG
                     LEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFG
                     RTNYNRPTRFINEISSDLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKR
                     GAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALHKKWGEGTVLEVSGSGARQEL
                     KINFPEVGLKKLLASVAPIEKKI"
BASE COUNT         5702 a         3928 c         3389 g         5595 t
ORIGIN      
        1 aatattttcg gaacattcaa ctttttaact ctatttatta ctagatttca taattaaaaa
       61 gcctactgac caagctagaa agcttgatac aataggcttt ttaaagactg attatttaac
      121 agcgtcttta agagctttac cagctttgaa tgctggtact ttagaagctg caattgtcat
      181 ttctttacca gtttgtgggt tgcgaccttt acgttctgcg cgctcacgaa cttcaaagtt
      241 accaaaaccg atcaattgaa ctttttcacc agctgcaaga tagtcagcta ctgctgcaaa
      301 tacagcttca actgctgctg ctgagtcttt cttagtcaat tctgtagctt ctgctacttt
      361 agcgatcaaa tcttgtttgt ttgccatgtt aatgattcct ccaaataatt tctaattaac
      421 aaatataatc atatcctaaa atccctttta ggtcaagtta aaaacgctat ttcttcccat
      481 tttatttatt ttttaggagt ggtaacgtat caaaatagcc caagcgttct cacccgtgtg
      541 agtttgaata atggaacccg tttccaaaac agaaattggc ttttcaacat aagcttgtaa
      601 gctttctttc atctcttttg cccaatcatc actaccagaa tatgaaattc caatctctgc
      661 tacagcacgt tcagaaagcg atgttatcaa ctcatctaac cattttttaa atgttttagt
      721 tccacgacct ttaaccattg gctgcaattc atggtctttc atttgcatga caacacggat
      781 attgagaagg gagctcaaca agccagttac acggccaatt cgtccacctt tgacaagatt
      841 ttccaaagtt gaaacaccaa tataaagctc tgtatggttt ttaacctctt ctacatgaga
      901 taaaattgcc tccatatctt taccttcttg agctaacttc gcagcctcaa caacttggaa
      961 tttcagggct tggtcagtga aggaactatc aacaacagtc acatctgcag tagataggct
     1021 agcaccttgg cgtgctgctt ctaccgtacc cgaaagagca tgggacatat gaatagcaag
     1081 aatctggcca ccatctttgc ataggtcttc aaaaatctca gcaaagacac ctacaggtgg
     1141 ctgacttgtt ttcggaagat tcttactttc ttgcatcaac tgaagaaatt taccttcttc
     1201 tttcaaatcc gcatcagaat aaacaacatt atcaatcatt acagataatg gaacaattgt
     1261 aatatctaat tgctttacta gttcaggttc aatagtaaca gatgaatcgg ttacaatctt
     1321 aatttttgtc atagtatcaa tctttctatt ttaggattca gattggtttc cttacttcta
     1381 attatatcaa aaaaaagatt aaaaatccta atggagtcaa tcaaattttc cgtaaaattt
     1441 gatataatca acttataaga aaagaggtgt cctatgatta aaaaaattta ccccattttt
     1501 accattttac taggtgctgc tatttatgct tttggactga cttattttgt agttccccat
     1561 catctctttg aaggaggggc gacaggcatt accctcatca ccttttatct ttttaaaatc
     1621 cctgtttccc tcatgaacct gctgattaat attccccttt tcatcctagc ttggaagatc
     1681 tttggagcca aatccctcta ttctagttta ctaggaacct tagctttgtc cgcctggtta
     1741 gctttttttg agcatattcc ccttcatatt gatcttcaag gtgatttact aatcacagcc
     1801 cttatagcgg gaatcctatt gggaattggc cttggaatta tttttaatgc tggaggtaca
     1861 actggcggaa ctgatattct agctcgtatt ctcaacaaat acactcatat atccatagga
     1921 aaactgctct ttatcttaga tttttgtatt ctcatgttga ttctcctaat cttcaaggat
     1981 ttgagattgg tttcctacac gcttttgttt gattttattg tttctcgtgt tattgatttg
     2041 attggtgaag gaggatatgc cggcaaaggc tttatgatta tcacaaaacg tcctgaccaa
     2101 cttgctaagg cgattaatga tgacctcgga agaggtgtta cttttatttc tggtcaaggc
     2161 tactatagta aagaaaattt gaaaatcatc tactgtattg tcggaagaaa tgaaattgtg
     2221 aaaacgaagg aaatgattca tcgaatcgat cctcaagcct ttataactat tacagaagcc
     2281 catgaaatcc taggagaagg cttcaccttt gaaaaagaat aaaaagaggt aatgtcgtga
     2341 cctcaaaagt tagactaaat catctatctt ttgggttaca gacaacctct tttttatttt
     2401 atttactcaa gctcttaata ccaattccga gttacttctt catcagcctt taactgatcc
     2461 actaattggt caactgagtc aaatttggtc atatctcgaa tgcgatcaag ccaataaacc
     2521 atgacggttt ccccataaat atcttgatta aaatcaaaaa tattgacttc aaaacgtgct
     2581 tcttctccat caaaggtcac atttttcccg acactagcca tagcacgata cttctgtctt
     2641 tgaatctcaa catcaacaac ataaacgcca tctgctggca tataagtacg gtctaaaagc
     2701 actaaattcg ctgtcggata accaattgta cgaccacgag cattaccatg aaccaccata
     2761 cctcttgatg gaagcggtgc ccccaaaagt tttcctgctt ctttcacatt tccatctaaa
     2821 atagcttgac ggatacgagt tgaactaatc tttcctttct catcttctac aggtggaaca
     2881 atgataactt ctccatcaaa gtaatccttt aaatcttctg ctgttttttt gtcagaacca
     2941 aatgtataat caaaacctgc aacaataatt ttggcattca tagccttgat ataagttgca
     3001 aagaattctt gtgcagtgag actagcgaat tgactactaa aatcaaggag atataattct
     3061 tctacacctt cgcgctttaa ttttctttca cgttcagcag ggttcaaaat atgcaaaaac
     3121 aaatctggat gataaggctc taaagcgatc tttggagatt cattaaaggt cataacgacg
     3181 ataggcaaca aatcctttct cgcagccttg ttggcaacac gaaataattc ttgatgcccc
     3241 ttatgtatgc catcaaaata gccgagaaca acgactgaat cagatggtgt gccaatatct
     3301 ttttggtttt ttataggaat agtaataatc ataaaataat tatatcatag cgatagctat
     3361 ttctggaaca gaaaatctga aatgttgttt ttttcacatg aagtgtacct gttttcaaaa
     3421 agcactttat tctatcgttg cttaactatg aactttgcaa tattcttctc aaaaacttgt
     3481 aggacatctt caaaattttg caaggagtga ttagacttgt tcggtaacca taaagtgtca
     3541 tactatgctt atgtatgaaa aagcaatgca actaactcct gagaacttta aattactaat
     3601 tggtgccgaa aaggtagaat ttagaatcga ggtacaccta tggctgtaaa atttacaaaa
     3661 tgagacaact tgggcaagat gtttgaagaa tttcctaaac tccctgattt gaagcaagtc
     3721 actttccctg atgacaaaaa aagccaaagc agtaaagaaa aactagatga ctgctttcca
     3781 acaacttcca tctagtgtgc ttcagactgg gctatttttc tctccatctg ttagcttgga
     3841 ttctcagacc gtttcagcta aagaatatct tttcccttat cagaaggaac gggctcaaac
     3901 cactcagaca agtgaaggga cgacaagcca atatttgaaa ccagatagca gtttttatag
     3961 tcaattgaaa taaaatctga agaaatcgag taggaaactc atatcaattt ttaacagtgt
     4021 tctattccag attcaatcca ctatacatat taaaaagtat gggtaccaaa acaaaaaaac
     4081 aggctctccg aaaactcgga aagccttatt ttaagctgtt tctagcttcc tcacctttac
     4141 atttcaaggt tcgggataaa aggttcaatg gaccttttta tttagcgatt gggtaaacag
     4201 aaacttgttt tttatcgcgt cctttacgtt caaagcgtac tacgccttca actttagcga
     4261 acaaagtatc gtctccacca cgaccaacgt ttacacctgg atagatgtgt gtaccacgtt
     4321 gacggtaaag gattgatcca cctgttacag tttgtccgtc agctgcttta gctccaagac
     4381 gttttgcttg tgaatcacgt ccgtttgatg tagaacctcc accttttttg tgggcgaaaa
     4441 gttgcaagtt gttaagagtc atttttaaca taatgttttc ctccgtgtta gttttctgtg
     4501 ataactctgg tttggacgaa ctcagaatag ttctccgata agtttgccat acctaagaaa
     4561 aatgattcaa agaataactg ggtcatttct ctctggtgtg aaggaagatc ttttggtatt
     4621 tcaaccatca gatagccacc ttcatcttcg tttaattcta ggattggttc atagcctgca
     4681 aatttctcaa tagaattgat aaagttaatg gcaagcgtag aaaccgatgc acacacgaca
     4741 tctaagccgt attcgccact ctcggcgtgt ccagtaattt ccgcactcct cagctcgcca
     4801 tcttcggctc tctcaaagac tgcctgtatc atgtgttctc cttaaaatta agcgttgatt
     4861 gcgttgatga caacttttgt atatggttga cggtgacctt gtttacggtg gctacctttt
     4921 ttaggtttgt acttgtaagt aaccactttc ttttgttttc cttgtttttc aacagttcca
     4981 actacagtag ctccagcaac aagtggagtt ccgacaacag tattttcacc accaacaaga
     5041 acaacttcgt taaaagtaac ttcttgacca gcttcaacgt tcaatttttc aacgtaaact
     5101 gcttgaccaa cttcaacttt aacttgtttt ccgccagttt tgataattgc gtatgtgctc
     5161 attatgcacc tcctatgatt tttatgggtt tccccgattt tttgtgaaga ctcgcctagc
     5221 atcgtgggac gaaccactta aacttgaata atcaagcaac gatgttcgtg cggttgcaca
     5281 ggatcgtgca tagtcaactc ttcaagtata gcatatctcc tattttctta caagtaataa
     5341 cacctaaaat caagcttttt cttttacttt tttctgccaa gaggcaaaaa gcatgctgag
     5401 gtaaaaaacg ctcatcataa taggaacacc aagaatggtc ttttcatgat agaaaatcgt
     5461 caaataggct gaaaagacaa cgccaaggac aaaactacta agcaggctaa caaatatgaa
     5521 tccttcacgc aaaaaaggag tgtgcttggt tcggaaataa tctccaaaag ccagcatggt
     5581 ccgtttgata ttccctgtca taaaagcgtt attataggca atacccgaca cttctccaaa
     5641 agcagttgtc accagtccca tacagaaggc caagggcggc actagataga tattatccac
     5701 agtttgcggc acaaaagcaa taatgattga taagattgcc aagggaatca aggacagaat
     5761 aggttttttc acaattctca atttttcctt ataaatcgtt aataaaaaga ctcccatcat
     5821 aaacgctagc aaggtgagaa ccttgtccct aacatccgaa acattatttt taattaattc
     5881 tactgaaaga aagacaacat ttccagtttg tccagctaca agggtattcc cgcgaacaat
     5941 aaaagtgtaa gcatccacat atccagcaca aaacgtcaaa aaaagtgcta accttttaga
     6001 ctgacgtgat atttttctta taggtaataa cctcattttc cctcccattg tattttctct
     6061 tagaaatatt gtaccatttc tttctaaaaa atcgtagact accatttaga ttttactatt
     6121 agcataaaaa taataataga caactattta tccaaaaata gatagaggta acatgtttgc
     6181 aaacaaagca tacgaatctt tagtaaaatc atttccatga aactagaata gagcccctct
     6241 tagcaaaaat cattatttta atttatttct aatcactcct tgacataaat aactctcacc
     6301 aataaaagac tatgtcttaa aaaaatggta taataaaatc aatacttggg cttgatggct
     6361 atgctactaa taacaattag gagagaaaat caggcacttg ttaacaacaa ggattatccc
     6421 cttgagatga aaggaacttt agaaatctta tgatgaacat gcaaaacatg atgcgtcaag
     6481 cacaaaaact tcaaaaacaa atggaacaaa gccaagctga acttgctgct atgcaatttg
     6541 ttggcaaatc tgctcaagat cttgtccaag cgaccttaac tggcgataag aaagttgtca
     6601 gcattgattt caatccagct gtcgttgacc cagaggacct tgagactctt tctgatatga
     6661 ccgttcaagc catcaactct gctcttgaac aaatcgatga aactaccaag aaaaaactgg
     6721 gtgctttcgc tgggaaatta cctttctaaa aacaaggagc tagaacaatg cttgtcgata
     6781 acaaaggcta agaaaggtgc aaaaatgact ctataatatt tgtagtgggt aaatccacta
     6841 tagatattat ggagcctatt ttattgtaga aaacgcataa tagcaggtgt caagacactt
     6901 aatattatgc gttttctcat gaaaaaattc tcttttcata ctcatttaaa atcaaaaagg
     6961 gaaattatcg ttttacggac atacatatta cagatttcta taggtcgtgt atagacagga
     7021 tatcatcgct tggaagtttt cctttttgac accaatcagt aatttagttc tcaggaatta
     7081 atggcagtgc ttttcgtaca tagtttcata actacagtat agcatagtat atcgctttat
     7141 agttttcact attgatgaac tgcttgagct gctgtgatga gggtcaactt gtaaacatca
     7201 tctgcattac atccacgaga aagatcatta actggcttgt ttaaaccttg caaaacaggt
     7261 cctacagccg caaagccacc caggcgttca gccatcttgt aaccgatatt tcctgcctcg
     7321 atacctggga agatgaagac atttgcttga ccagctaccg tacttccagg agctttcaga
     7381 gctgcagttt caggaacaaa ggctgcatca aattgcaact caccatcgat ttcaaggtca
     7441 ggacgcaagt cgtgagcaat tttagttgct tcaacgacct tatcaacgct ttcaccaaac
     7501 cctgaacctt tagtagaata gctcaacatg gcaattttag gttcgatgcc aaacatctta
     7561 gctgtgattg ctgagttgat ggcaatttca gccaaggctt ctgcatctgg attgatgtta
     7621 atggcacagt ctccaaatag gtaacgttcc gtaccacgaa ccatgaggaa ggctcctgaa
     7681 gtacgagtta catttggacg agttttgatg atttgtagag ctggacgaac tgttgaagct
     7741 gttgagtgaa tcgctcctga caccattcca tcaaccaagc ccaagtaaac caacatcaca
     7801 ccaaagtagt tgacatcttc aaccaaaacc ttgcgtacat cttcttcagt cattttgccc
     7861 ttgcgacgct ccaccaaggc agaaaccatt tcttcaaatt gaggataatg ttgagggtcg
     7921 atgacctcat aaccatccat gattccttca atttcaagat aaattttaat tttttcagga
     7981 tttccaagca aaacaggaat cacttctgtt tcttttacta agcgttttgt tgcttgaaga
     8041 atacgaggct cttccccttc agggagaacg atacgagcat ttttaccaac aaggttggct
     8101 ttgagacttt caaaaacttc catgagtttt ctcctttaag ataataatta tactctgaga
     8161 cagtttttat agagtattag ttgataactg ggtaataagg ttactgaaat catccggcaa
     8221 gggactttct aactgcaagt cttgctctaa aaatggatga taaaaggata ggtaatggca
     8281 atgcagagcc tgacgttgaa taccatcttc cagactacca ccatacaaat catctcccag
     8341 caaaggaaaa ccgatataag aaaaatggac tcggatttga tgggttcgac cagtgtgcag
     8401 gtgaatatag accaagtgaa tatttccata agaagctaca atcttgtatg aagtatgggc
     8461 atactttccg cctttagcca ctcgtctggt aataatggaa tcttcatcac gcgcaatcgg
     8521 agcaataatt tccccttctg gctccaaatg tccatctccc ttaaccaaag caaagtagcg
     8581 tttctcgata gatttcttct gcaactgctt gtctaatcgt gcatgggcat aaccgtgctt
     8641 ggcaaagagc atcaagccag aagtgtccct atctagtctg gtaacaatgt gaacctgctg
     8701 attttcataa ttttgcttga catagtaacc cttgataaaa ttggcaatgg tattagagtg
     8761 attgacacta ggaatagaag ccactccata gggtttattc aagactagaa agtggtcatc
     8821 ctcatagaga atatctaatg gatgctcaat agcctccaag gtttcaaagc cttcctcagc
     8881 gggaatgtaa atggtaacgt agtctccaac gtccaataga tacgttgcat tttgcggttg
     8941 attattgacc agaatcgctc cacctcgaaa cttaatctta gccagcaatc ccttagaaac
     9001 ctcgtgcttt tttaaaaagg tcttaacctt gacatgttca tctgcgataa attcaaacct
     9061 cattcatcca cctcaccgat aaaggcatcc ttaacacggt tccagaaact ggtatggcta
     9121 ggagtcgcga caaagtgaat cttatgatgg tcgatttgat actcaatacg ctcaatatta
     9181 cggaaagaat aaacgctatt gtcaaccgaa atagtatgat aatcgtttct tgttggaata
     9241 agttcaatct tatccttctt aggcacaata atggaagagc ccagtgttcg ataaacacga
     9301 ttattaaggc tggcaatttc cgttaattgc aaagcttcaa tggtagggtg taaaacagca
     9361 ccgccaagag acttgttata ggcagtacta ccagtcggtg tcgaaactgt tagcccgtct
     9421 ccacgaaaac gttcaaaggg aacaccattt attacaatat ctgccaccat ggttcgatca
     9481 gacctgcgga tgctggcttc gttgagtgct ctgaaaatct taacttcacc attttcaaga
     9541 aagaccttca cattcagaac agggtaagaa acccttgccc cagtatctag ctgcaaatta
     9601 gtcactagct tgtccaactc aaaatcacga taatctgtat agaagcccaa atgtccagta
     9661 tgaagaccga taaagcggac cttgtcaagc tgattttcgt acttatgaaa ggccgacaag
     9721 agcataccat ccccgccaat ggaaatgaca atatccggat tggtatcatt gagtataaac
     9781 tgatttctct tcaaacgatc tcgcaattca tacaaaaccc tttgactctg cggttttcta
     9841 ttggctatca gatcaattcg tttacctgta ttcttcatct gtatcgtcac tgtttcctac
     9901 accgtcattt aattttctac tcaaaggatc aaaaagtgcc tgggcttctt ggatatcatc
     9961 acgaatttca cccatttctt catccaactg atgggcgatt ctagctgtaa tttccagtcg
    10021 cttcttaatc tcatctggga aatccccttg gtacttgtag ttgagagaat gttctatcgt
    10081 tgcccagaaa ttcatggcca aagtacgaat ttgaatttct gccaaaatag tcttagctcc
    10141 attgatggta tcaaccgtat attctactac cacatgatag gaacgatagc ctgatgcttt
    10201 tctatgagta atgtaatctc gctcctgtat gattcgcata tcctgacgct tgtgcaaaat
    10261 atccactact tccttgacgt catctacaaa ctgaaccatc acacgtaagc cagcaatatc
    10321 ctgcaaatcg tgttccaagg tcgcataagt aatgctacga cgagccattt tttctttgat
    10381 gctctcaatt ggcttgactc gaccggtcac aaactcaatt ggagaatgct tattttgctt
    10441 acgatattgc ttacgaatac cacgaagttt aatctttaac tcaccaacag cttgaatgta
    10501 aggatctaga aattcttccc attctaaggt catatattct cccttgttct catattatcc
    10561 gtcaaaaata tctttgattt tttctccaga ttcatataca ataaatacaa tgcttattat
    10621 accataaatc cgctttcaac gataaaaaaa ggtaagaaaa atgaaacatt tagaaattga
    10681 attgaaaaca ctattgaaaa aagatgaata caatcgtcta aaagaccagt tcacaggtgt
    10741 cactcctgtt cttcaaacaa attactacat cgacacgctt gattttgaac tgcgagaaaa
    10801 gaaagtcgct atgcgcattc gaacctttga agactgggct gagttgacac tcaaagtccc
    10861 gcagagtgtt ggaaacatgg aatacaacca aaaattgcaa ctaaaagatg ctgagaacta
    10921 tctgagtaag gaagaacttc ctcaagggct agtactggat gaattggcga aacatggtat
    10981 ccaaagtaag aactggcagg ttcttggttg tctaacaacg cttcgctatg aaatgaaaac
    11041 agctattggt ctcatggcac tggatcagag ccgatacttt gatatgacag attacgaatt
    11101 ggagcttgaa gtggaaaatc atgagcaagg caaacaggat ttccgacaat ttttagagaa
    11161 aaatcagatt tcctaccaaa aagctccttc aaaattggtt cgatttgtca aaagtatgaa
    11221 aaatagctga aataatctcc attttttggt aaaatagaaa agataaaaat acacaaatcc
    11281 cagttcatat atgtaaggta aatataacta ggatttataa agtttacaga ggacggtcta
    11341 taatgtcaga tagaaaaaac atgaaacttt tcgcactcaa ctctaaccaa gagattgcac
    11401 aaaaaattgc ccaagctgtt ggtgtcccac ttggaaaact atcatcacgt caattttcag
    11461 acggagaaat ccaagtaaat atcgaagaaa gtgtccgtgg ttatgatgtt tacatcatcc
    11521 aatcaacaag tttccctgtc aacaaccacc taatggaatt gttaatcatg gtcgatgctt
    11581 gtgtgcgtgc aagtgcccac agtatcaacg ttgtccttcc atattttggc tatgcacgtc
    11641 aagaccgcat tgcttgtcct cgtgagccac ttacagcaaa actagttgcc aatatgctgg
    11701 ttaaggctgg agttgatcgt atcctgactc ttgatttgca tgccgttcag gttcaaggtt
    11761 tctttgatat tccagtggat aatcttttca ctgttcccct attcgcaaaa cattactgcg
    11821 ataaaggatt gcttggttca gatgttgttg tcgttagccc taaaaattca ggtgtcaaac
    11881 gtgcgcgtag cctggctgaa tatcttgatg ctcctatcgc cattatcgac taccctcaag
    11941 acgatgcaac tcgtaacgaa ggttatatta ttggtgatgt tgaaggtaag aaagctatct
    12001 tgattgatga tattttaaat acaggacgta ccttctctga agcttctaaa atcgttgaac
    12061 gtgaaggagc tacagaaatt tatgctgttt ctagccacgg tctcttcgtc gagggagctg
    12121 ctgagcttct tgacaatact aatattaaag aaattcttgt gactgattca gtagcaacaa
    12181 aagaaaaaac tcctaaaaat gtatgctaca tcactgctag tgagttaatt ggtgatgcta
    12241 tcgtccgtat tcacgaaaga aaaccagtca gcccactctt tgcctacaat aaaaagaaat
    12301 aaggtgattc tttgatttat ttggacaatg ctgcaacgac tcctatgtca gcagttgcta
    12361 tttcagctat gaccaaggtt atgcaagaaa cccacggaaa tccttctagt attcatggtc
    12421 atggtcgtca agctggcaaa ctcttgcgag aagcccgtca ggaactagcc cagttactaa
    12481 ggacaaaacc tcaacatatc tttttcactt ctggtgggac tgaaggcaat aatactacca
    12541 tcattggcta ctgtcttcgt caccaagaac aaggaaaaca tatcatcaca actgccatcg
    12601 agcaccatgc tgtccttgaa acaattgatt acttggttca acactttggg tttgaagcaa
    12661 ccattatcca gccagaaaat caagaaatca cagcccagca aattcaaaag gctttacgtg
    12721 acgatacgat tttggtttct actatgtttg ccaataatga gacaggaaac ctacttccca
    12781 tcgctgaaat tggccaaata ctcaagcaac accctgctgc ctatcatgtt gatgcagttc
    12841 aggctattgg taaaatccca attcattcag aagaattggg cattgatttt ctcactgctt
    12901 ctgcccacaa attccatggt cctaagggaa tcggttttct ctacgcatct agcatggact
    12961 ttgattccta tctacatggc ggagatcagg aacagaaaaa acgtgcagga actgaaaatc
    13021 tgcctgccat cgtaggcatg gttgcagccc taaaagaaga cctagaaaaa caagaagaac
    13081 attttcaaca tgtacaaaat ctagaaactg cctttctggc agagctggag ggcattcagt
    13141 attacttgaa tagaggaaaa catcatctcc cttatgttct caatattgga tttcctggtc
    13201 agaaaaatga cctcttactc cttcggctag atttagctgg aatttcaatc tctactggct
    13261 cagcctgtac tgcaggcgtt gtccaatcca gccatgttct taaagccatg catggcgcaa
    13321 attcagaacg cttgaaggaa tcccttcgca tcagtttgtc gccacaaaat accgttgaag
    13381 acctacaaac cctcgcaaaa accttaaaag aaattatcgg aggttagcca tatggcattt
    13441 gaaaaaatca ttcagttaaa aaattgtcgt tacgattaca ctcttagccc ttctgttaaa
    13501 aaattcaccc tcaaagataa cacctttttt gaaactaagg ttggtaacta tgaactgact
    13561 cgccttttgg aaaaagtgcc aaacagcggt gaaggcttcc aactcaaaat catcattaac
    13621 aaggaactta caggggctaa aatcaatatc actgacaagt ttggccttcg tctagttgat
    13681 attttcaaat cagaagacca ccatattcat caggaaaaat tctacttcct catggatagc
    13741 ttggtagaac gtggtgtctt tacaaaatcg gaaagataga gccaaaatgt ttgaactgac
    13801 ctataaggac tgctatcatg tagagcgtac tctcaagtat gaggatcatg aggctctcat
    13861 gttgactttg tcaggatgtg taaccttacc agatacactt tatgtgactt ctctgacttt
    13921 taggggcaaa aaagtttatc aggggctggt cggagacctc taccgttttc tatctcatgc
    13981 agatttttta catcaaaact aagatttttc ttagtttttt cttatttttg ttgatttttt
    14041 cacaatgttt ctataaaata gaagaataga aaggttgtga ttttgtgaaa gataaacagt
    14101 ttgctattcc aaaagctaca gcaaaaagac tctctctcta ctatcgaatt tttaagagat
    14161 ttcatgcaga aaagattgaa cgtgccaact ctaagcaaat tgcagaggct atcggtattg
    14221 attcagcgac cgtacgtcgt gatttttcct attttggtga acttggtcgt cgtggttttg
    14281 gctatgatgt caaaaaatta atgacatttt ttgccgattt gctcaatgac aactctatta
    14341 ccaatgtcat gctggttggt attggaaata tgggccatgc ccttctccac taccgcttcc
    14401 acgaacgtaa caagatgaag attatcatgg cctttgacct agacgaccat cctgaagtcg
    14461 gtacccaaac tcctgacggg attcccattt acgggatttc tcagatcaag gataaaatca
    14521 aggatgctga tgtgaagact gctatcctaa ctgttcccag cgtcaagtca caagaggttg
    14581 ctaatctctt ggttgatgct ggtgtgaaag gaattctcag tttttcacca gtccatctgc
    14641 atttaccaaa agacgtggtc gttcagtatg tcgatttgac aagtgaactc caaaccctcc
    14701 tctacttcat gcgaaaagag gattagaaag cgaaaatcat tttatgaaaa aaccagttat
    14761 tgggattaca ggaaacgaaa aagctcatcc agatgatgac atcatgatga gctacgcagc
    14821 aaaaggcttt gttgaaggcg ttaaagatgc tggagggatt cccatcatcc taccgattgg
    14881 tgatcaagaa atggcctgcc actatatcag tttgattgac aagctcatct tgacaggtgg
    14941 gcaaaatgtc gatccaaaat tctatggcga acccaaaacc attgatagcg atgactatca
    15001 ccttcaaaga gatatcttcg aactggccct catcaaggaa gctattaaac agaaaaagcc
    15061 cattttctct gtctgccgtg gtacccaact ctttaacgtt gccatgggtg gaactttgta
    15121 ccaagatatc gaagaccatt ggcaggattc ttctgttgag tacacaactc aacgcttggt
    15181 aacagaacca gataccgttc tccaagaaat ctatggagaa atctctcata tcaactcctt
    15241 ccaccaccag agcatcaagg acttagcacc aaatttaaaa gttgtggctc atgatcctaa
    15301 agatggtatc attgaggctg tcatgagtac ggatgatgtc gcctttctcg gtgtccaatg
    15361 gcatccagaa cttctttttg aaaatcgtcc caaagataaa aaactctttg actatgtcgt
    15421 taatgaactt tagattaaat ctgtcttttc acgataacta aagtaattag aatgagagac
    15481 aatcaaatgg tccaagagaa caatccccat cagttcgcag gcttctttaa caagtttagt
    15541 gacatgatca tcattttggc taggcgctac cgctcctgaa ggatgattgt ggaccaagat
    15601 aagagaagtc gccatatgct tgattgcata gtgaagaatc tctcgcggtt cagcgatact
    15661 acgagttaca gaaccgataa aaatggtctg ctgatggatg atttgatttt gagtattgag
    15721 atagagtgcc accaggtgct cttgtttttt atcccctaat tcctgctgca tcttcttggc
    15781 caacttttga ctgctgagaa tactttccat ttcaagagtc tcgtgtttgt gaatacgatg
    15841 ccccagttca atcatagctt gtaattctat ggccttaaca cgcccaatac cagacaaact
    15901 ctgcaattcc tgcagggtca tttttttcaa atccgttagg cttgaaagat tgttcaagac
    15961 tttttgggca atttcaaaaa cgctagcttg acgtgttcct gtcctgagta aaatagctag
    16021 caactcttgg ttactaagcg cttcaactcc ttccttggcc agcctttctc ttggtaatag
    16081 tgaatcttct tggaatgaaa tactgtacat aaaaatcctc ctcactttat tattcgtgag
    16141 aaggatggaa aattagattt ttttctcaat tggagccaca ctggctaaaa gttttttcaa
    16201 acctacttct gggaaattga ttttcaattc ctgcctagca ccgctacctg aaacttccag
    16261 aacagttccc tctccccatt tcttgtggag agcaatgtca ccaatggacc aatttgcctc
    16321 gctagatgct ggttttgcgc cagctgtaaa ttgaccaaat ggaagaccgc ttgactggat
    16381 tgattttggg gcagcaccgc gtttacggtc ttgaagagcc tgagccaaac tcataccttg
    16441 accaaaggaa atactaccac tgctatatga tgccttaaag cttgtatttg caggacgagc
    16501 cagaccttga tactcaagca agtctgaact gatttcgtta ataaaacgag tcggacggtt
    16561 ataattggta cgaccaaaaa gcaagcgtga gttggcattg gtcagataga gaattttctc
    16621 tgcacgcgtg atacctacat aggctagacg gcgctcttct tctaattcat ctggatcttc
    16681 agtcgcacga ctaagtggaa agacattttc ttccatccca atcaaaaaga caactggaaa
    16741 ttcgagacct ttggcagcat gcagggtcat caaggtcact tctgatgtct cctgactacc
    16801 tgaatctgtg tcggcaatca aagccaagtc atttaagaaa cgactcagtt tgtccagacc
    16861 agtttcctct tctgtcacat cagtggtgtc atcaaagttc ttcgtaacag aaagaaactc
    16921 ttcgatattt tcaacccttg ccttgctttc tagagtcgct tgggtgttaa gaatatcgac
    16981 ataacctgtt ttttctagga cggactcaac caactctgta atgcttaagt ggtctagctg
    17041 ctcccgcaaa tcaagcatca tattggcaaa atcccagata gattgggctg ccttaccctt
    17101 gataccagac aacataatat tagcagaagc atccagcata gacatatttt gcaaatttgc
    17161 aaaatcacgg attttctcaa ctgtacctag accaattcca cgtttaggct cgttgataat
    17221 acgctcaaaa ctaatattgt cactcaaatt agcaataagg ttgagataag caataatatc
    17281 gcgaatttcc ttacggctgt agaatttggt tccgccaacc atggtataag gaatgttaga
    17341 cttgagcagg gcttcctcaa ttgtacggga ctgggcatta gtccgataga gaactgcaaa
    17401 atccttatga aggaagtttt gactgcgact aagttcatcg atggttctgg ctacaaatac
    17461 agcctcatcc agctcatcat cggcacgata gtaaacgatt tgctccccat cagcgttttg
    17521 agtccagaga tttttaggac ggcgattttt attattttta ataacctcgt tggccgcttg
    17581 gagaatggtt ttggttgagc ggtaattttc ctccaacaaa acaaccttgg ctttggggta
    17641 atccttttca aagtccaaga tattctgcat atcagcacca cgccaaccgt agatagactg
    17701 gtccgcatcc ccaaccacac agatattttt aaaacgggaa gccaagagtt tgactaattg
    17761 gtactgagcg tggttggtat cttggtactc atcaacgtgg atgtattgga atttttgctg
    17821 gtagtaggtc aaaacatcag gattttgatc aaagagacgc aaggtcagca taatcaaatc
    17881 atcaaagtca acggattcag actgacgaag ttctttttga taggctgtat aacactgggc
    17941 cacaatttgc gtatacatat cgccagcttg ggcagcataa gcaacatcat caatcaaatc
    18001 attcttagca ttggaaatgg tccccaaaat agttcgttca ttccattttt taggatccaa
    18061 gttcaactgt ttgagaatac gtttcatgag cgttcgctgt tcaccaggat ccacaattgt
    18121 aaaattacga ttgtagccaa tatggtccgc atcgcgacgc aaaatacgca cacacatgga
    18181 gtggaaggtc gcaatcagac agtcctgagt cgctggattg aggctataag cacgctcttt
    18241 catctcacgc gcagccttgt tggtaaaggt aatggccaag atattccaag gattgaccag
    18301 cttttcatca atcaaataag cgatacggtg ggtcaaaaca cgagtctttc cagaaccagc
    18361 ccctgccatg attagcaagg gaccttctgt cgtttgcacc gcctcagcct gacggtcatt
    18421 cattccattt aataatgcgt tcatcttctc ttccttactc ttgaagtcaa tatttctatt
    18481 atatcagaaa tcagggaaaa tagaaacttt acggggagta gcaaaatata gtggattgaa
    18541 actagaatac tacactgtgg gtttctaaaa cactcgactt tttcacccaa ttttttcata
    18601 aactagctca atac
//
LOCUS       DBERMM010000040        17250 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.042, whole genome shotgun sequence.
ACCESSION   DBERMM010000040 DBERMM010000000
VERSION     DBERMM010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 17250)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17250)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17250
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.042"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            23..193
                     /locus_tag="ACL8AS_001665"
                     /pseudo
     CDS             23..193
                     /locus_tag="ACL8AS_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhrA family quorum-sensing system peptide"
     gene            595..909
                     /locus_tag="ACL8AS_001666"
     CDS             595..909
                     /locus_tag="ACL8AS_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HGS1229490.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            925..1311
                     /locus_tag="ACL8AS_001667"
     CDS             925..1311
                     /locus_tag="ACL8AS_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HGS1229491.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            1340..2725
                     /locus_tag="ACL8AS_001668"
     CDS             1340..2725
                     /locus_tag="ACL8AS_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /protein_id="HGS1229492.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            2728..2880
                     /locus_tag="ACL8AS_001669"
     CDS             2728..2880
                     /locus_tag="ACL8AS_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229493.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            2903..4105
                     /gene="mobT"
                     /locus_tag="ACL8AS_001670"
                     /pseudo
     CDS             2903..4105
                     /gene="mobT"
                     /locus_tag="ACL8AS_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MobT family relaxase"
     gene            4154..4321
                     /locus_tag="ACL8AS_001671"
     CDS             4154..4321
                     /locus_tag="ACL8AS_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MLS leader peptide"
                     /protein_id="HGS1229494.1"
                     /translation="MGDKTVRVRADLHHIIKIETAKNGGNVKEVMEIRLRSKLKSVLI
                     VHYLKILYNRN"
     gene            4370..4453
                     /locus_tag="ACL8AS_001672"
     CDS             4370..4453
                     /locus_tag="ACL8AS_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0031556 - transcriptional attenuation by
                     ribosome [Evidence IEA];
                     GO_process: GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="HGS1229495.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
     gene            4578..5315
                     /gene="erm(B)"
                     /locus_tag="ACL8AS_001673"
     CDS             4578..5315
                     /gene="erm(B)"
                     /locus_tag="ACL8AS_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011100845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /protein_id="HGS1229496.1"
                     /translation="MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLT
                     TKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGNIP
                     YHLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAE
                     CFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHA
                     KVNNLSTITYEQVLSIFNSYLLFNGRK"
     gene            complement(5572..6819)
                     /locus_tag="ACL8AS_001674"
     CDS             complement(5572..6819)
                     /locus_tag="ACL8AS_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HGS1229497.1"
                     /translation="MSHNDSILNILGIKDKNIKIISVEEAEHNNDSVKEYITLITATL
                     SYPINRCRNCGFPTVNKDGFRKTHVRLASLNGRRYELELRKQRYKCKSCHTTFGAITN
                     LTKENQTLSSDLKNQIMLLARKGLSGQLIAEMCHCSPSSVRRTILERMEPHYRVAKLP
                     KHLCFDEFRSIKSVMSFICCDAETHQIVTKLQDRLSPTIVDYFESRYSKAERECVQSV
                     VIDLNAQYQSFIYRLFPNANIIIDRFHLVQLAGRALDNCRISILKQLDKQSQEYKIMK
                     SHWKLFHKKAEDLHPEEVVFLRGVKQYMTRQNAVDLITSKFSKFAEVYQTYQDITKAL
                     NERNSELLESTILDYQKTNTEMDTAIQTLRQNRKYVLNSAKFEYSNGPLEGINRKIKT
                     LKRTCYGFANQKFFFLRIDCIFS"
     gene            6999..7220
                     /locus_tag="ACL8AS_001675"
     CDS             6999..7220
                     /locus_tag="ACL8AS_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229498.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            7337..7834
                     /locus_tag="ACL8AS_001676"
     CDS             7337..7834
                     /locus_tag="ACL8AS_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HGS1229499.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            7923..8315
                     /locus_tag="ACL8AS_001677"
     CDS             7923..8315
                     /locus_tag="ACL8AS_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229500.1"
                     /translation="MKKIRSYTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAV
                     MILGNLPPLSMIEGAFLKYFGIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTY
                     AGKKVTLGRNQPQEAITAVRSEFYGISN"
     gene            8299..10744
                     /locus_tag="ACL8AS_001678"
                     /pseudo
     CDS             8299..10744
                     /locus_tag="ACL8AS_001678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331151.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            10747..12924
                     /locus_tag="ACL8AS_001679"
     CDS             10747..12924
                     /locus_tag="ACL8AS_001679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CD3337/EF1877 family mobilome membrane protein"
                     /protein_id="HGS1229501.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYAPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            12921..13922
                     /locus_tag="ACL8AS_001680"
     CDS             12921..13922
                     /locus_tag="ACL8AS_001680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HGS1229502.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            13919..14854
                     /locus_tag="ACL8AS_001681"
     CDS             13919..14854
                     /locus_tag="ACL8AS_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229503.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYYKVNPHKKVVIALWV
                     LLGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKS
                     IDNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQ
                     LITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSI
                     TTNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVT
                     VSLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            15168..15215
                     /locus_tag="ACL8AS_001682"
                     /pseudo
     CDS             15168..15215
                     /locus_tag="ACL8AS_001682"
                     /inference="COORDINATES: protein motif:HMM:NF011335.0"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            15231..17150
                     /gene="tet(M)"
                     /locus_tag="ACL8AS_001683"
     CDS             15231..17150
                     /gene="tet(M)"
                     /locus_tag="ACL8AS_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HGS1229504.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQNIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFQNCSLFPVYH
                     GSAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLH
                     LRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLG
                     KVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVA
                     QLPLGSGVQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
BASE COUNT         5616 a         3067 c         3576 g         4991 t
ORIGIN      
        1 aaaaagaaag gggtttcatt gcatgagaaa aaaacgtgga attaaaaaat tagttacatt
       61 tgcatgacta ggtgttttta tgtttagtaa tacaattcct taccaacagt ttattcagaa
      121 gaataaacaa ttggagattc gagtgcaatc acaaaaggag tccaatggtc ttgatgttgg
      181 gaaggctgat tagttgatta aatgatgaaa atactaatta actatatggt atttctgttt
      241 tatctaattt ttaattagaa aaatagcata aaaatctagt tatccgcata aaaactggac
      301 ttatcacact ttatcaaggt caaaaccact caatttacta ctaatttact acttatgaat
      361 gagctttgat acgacgattt atccttgaaa agtgaagata taaagatact tccaataaaa
      421 tttgaatatt taataggtag acacttcaaa aaatgaggtg tctatttttt tacccgattt
      481 tgaaaggaag tgaacttatg aaaacaaaaa atcaagaatc aaaaggtcgt tccccactct
      541 ttaagaccat caaacattca ttcagccaat aaaaaagaaa ggataggtaa aaatatggaa
      601 cttaaatttg tgattcccaa catggaaaaa acattcggca atttagaatt tgctggcgag
      661 gataaagtcg ttcagcgaag aatcaacgga cggctaactg tcttatcaag aagctataat
      721 ctctattctg atgttcaaag agcagatgat attgtggtgg tgcttcctgc tgaagctggc
      781 gaaaaacatt tcggctttga ggaacgtgtg aagttagtca atccacgtat taccgcagag
      841 ggctacaaaa tcggcactcg tggttttaca aattaccttt tacatgctga cgacatgata
      901 aaagaataaa gaaagagagg aaaaatgatg agattagcaa atggcattgt attagataaa
      961 gacacgactt ttggagaatt gaaattctct gctctacgtc gtgaagtgag aatccaaaat
     1021 gaagacgggt cggtttcaga tgaaatcaag gaacgtacct atgacttaaa atccaaagga
     1081 caaggacgca tgattcaagt aagtattcct gccagcgtgc ctttgaaaga gtttgattat
     1141 aacgcacggg tggaacttat caatcccatt gcggacaccg ttgctactgc cacctatcaa
     1201 ggagcagatg ttgactggta tatcaaggca gacgatattg tgctgacaaa ggattctagt
     1261 tcattcaaag ctcaaccaca agcaaagaaa gaaccgacac aagacaaata gtcgctaggt
     1321 agaaaggaga ctttttcgca tgaaacagcg tggtaaaagg attcgcccat ctggtaaaga
     1381 tttagtcttt cattttacga tagcgtcact cctgcctgtt ttcctgctgg ttgtcggact
     1441 gtttcatgtg aagacaatcc agcagatcaa ctggcaggat tttaacctat cacaagcaga
     1501 taagattgac attccctatt taattatcag tttcagtgtc gcaattctta tctgcttgct
     1561 ggtagcgttt gtattcaaac gggttcgcta tgatacggtt aaacaacttt accaccgtca
     1621 aaaactggca aagatgatac ttgaaaacaa gtggtatgaa tctgaacagg tcaaaacaga
     1681 gggtttcttt aaagatagtg ctggtcgtac aaaggaaaag ataacctact tccctaaaat
     1741 gtattatcga cttaaaaatg gcttgataca gatacgggtg gaaatcacgc tgggaaaata
     1801 tcaagaccaa ctcttacact tggaaaagaa attagagagt ggcttgtact gtgagctgac
     1861 ggataaagag ttaaaggatt cctatgtgga atatactttg ctctatgaca ccatagccag
     1921 tcgtatttct attgatgaag tagaagctaa agatggtaaa cttcgcttaa tgaaaaacgt
     1981 atggtgggaa tatgataagc tccctcatat gttgattgct ggtggtacag gtggcggtaa
     2041 aacttacttt atactgacac tgattgaagc cttgcttcat acagattcaa aactgtatat
     2101 tcttgacccg aaaaatgctg accttgcgga cttaggttct gtgatggcaa atgtctacta
     2161 tagaaaagaa gacttgcttt cttgcattga aacattctat gaagaaatga tgaaacgtag
     2221 tgaggaaatg aagcagatga agaactataa gactggcaaa aattatgctt acttaggtct
     2281 cccggcacac ttcttaatct ttgatgaata cgtcgctttc atggaaatgc tgggaacaaa
     2341 agaaaacacc gcagttatga ataagctgaa acagattgtc atgttaggtc gtcaagctgg
     2401 cttctttcta atactggctt gtcaacgtcc agacgcaaaa tatttaggcg acggaatccg
     2461 tgatcagttt aatttcagag tggctttagg tcgtatgtct gaaatgggct atggcatgat
     2521 gtttggcagt gacgtacaaa aggatttctt cttaaagcga atcaaaggtc gtggctatgt
     2581 tgatgtagga acaagtgtca tatcagagtt ttatactccc cttgtaccaa aaggatatga
     2641 tttcttggag gaaattaaaa agttatccaa cagcagacag tccacgcagg cgacgtgcga
     2701 agcggaagtc gcaggtgtgg actgatcttg ctggctggtg tggcaatagc cacgccagca
     2761 cttaaccccc cgtatctaac aggggggtac aaatcgacag gaaacagtca aaaaaacatt
     2821 agaaaatcct ttggttacaa gggatttaca aaatttcagc gtatgtcaaa tgggctttaa
     2881 aagttgacat acgccttttt gattggaggg atttttactg aatgaacaaa cttggttaca
     2941 gcatttaaaa gaaaaacgct tggcttatgg actatctcaa aaccgtttag ctgttgcgac
     3001 tggtattaca aggcagtatc taagcgatat tgaaacagga aaagtcaagc catcagagga
     3061 tttacagcag tccctttggg aagctctgga acgcttcaat cccgacgctc cccttgaaat
     3121 gctgtttgat tatgtaagga ttcgctttcc gacaacagac gtacagcagg tggtcgaaaa
     3181 catcttacaa ctgaaactgt cctattttct tcatgaggac tatggtttct attcttattc
     3241 agagcattat gctttaggcg acatattcgt cctttgctcc catgaactgg acaaaggagt
     3301 tctggtggaa ttgaaaggtc gtgggtgcag acaatttgaa agctatcttc tggcacaaca
     3361 aagaagctgg tatgagttct ttatggacgt tttggtggct ggcggtgtga tgaaacgcct
     3421 tgaccttgcc attaacgata agacagggat tttgaatatc cctgtactca ctgaaaagtg
     3481 ccaacaggaa gaatgtatct ccgtcttccg cagttttaaa agctatcgca gtggcgaact
     3541 ggtacgcaaa gaggaaaagg aatgtatggg aaacaccctc tatatcggtt cattacaaag
     3601 tgaagtttat ttctgtatct atgaaaagga ctacgagcag tacaagaaaa atgatattcc
     3661 cattgaagac gcagaagtaa aaaaccgttt tgagattcga ttgaaaaatg agcgtgccta
     3721 ttatgcagtc cgtgatttac tcgtctatga caatccagag cataccgcct ttaaaattat
     3781 caatcggtat atccgttttg tagataaaga cgattccaaa cctcgttctg attggaaact
     3841 gaatgaagaa tgggcttggt ttattgggaa caatcgtgaa cgattaaaac taaccacaaa
     3901 accagagcct tactccttcc aaaggacgct gaactggcta tctcatcaag ttgccccgac
     3961 cttaaaggtt gcgattaaac ttgatgaaat caaccagacg caggttgtaa aagacattct
     4021 cgaccatgcg aaactgacag accgacacaa gcagattttg aagcaacagt cagtaaaaga
     4081 acaggacgtg ataacaacaa aaaaaggata tctgtcaacc ataccagttg acagatatcc
     4141 aaaaaaagat ataatgggag ataagacggt tcgtgttcgt gctgacttgc accatatcat
     4201 aaaaatcgaa acagcaaaga atggcggaaa cgtaaaagaa gttatggaaa taagacttag
     4261 aagcaaactt aagagtgtgt tgatagtgca ttatcttaaa attttgtata ataggaattg
     4321 aagttaaatt agatgctaaa aatttgtaat taagaaggag ggattcgtca tgttggtatt
     4381 ccaaatgcgt aatgtagata aaacatctac tgttttgaaa cagactaaaa acagtgatta
     4441 cgcagataaa taaatacgtt agattaattc ctaccagtga ctaatcttat gactttttaa
     4501 acagataact aaaattacaa acaaatcgtt taacttctgt atttgtttat agatgtaatc
     4561 acttcaggag agattacatg aacaaaaata taaaatattc tcaaaacttt ttaacgagtg
     4621 aaaaagtact caaccaaata ataaaacaat tgaatttaaa agaaaccgat accgtttacg
     4681 aaattggaac aggtaaaggg catttaacga cgaaactggc taaaataagt aaacaggtaa
     4741 cgtctattga attagacagt catctattca acttatcgtc agaaaaatta aaactgaata
     4801 ctcgtgtcac tttaattcac caagatattc tacagtttca attccctaac aaacagaggt
     4861 ataaaattgt tgggaatatt ccttaccatt taagcacaca aattattaaa aaagtggttt
     4921 ttgaaagccg tgcgtctgac atctatctga ttgttgaaga aggattctac aagcgtacct
     4981 tggatattca ccgaacacta gggttgctct tgcacactca agtctcgatt cagcaattgc
     5041 ttaagctgcc agcggaatgc tttcatccta aaccaaaagt aaacagtgtc ttaataaaac
     5101 ttacccgcca taccacagat gttccagata aatattggaa gctatatacg tactttgttt
     5161 caaaatgggt caatcgagaa tatcgtcaac tgtttactaa aaatcagttt catcaagcaa
     5221 tgaaacacgc caaagtaaac aatttaagta ccattactta tgagcaagta ttgtctattt
     5281 ttaatagtta tctattattt aacgggagga aataattcta tgagtcgctt ttttaaattt
     5341 ggaaagttac acgttactaa agggaatgga gataaattat tagatatact actgacagct
     5401 tccaagaagc taaagaggtc cctagcgcct acggggaatt tgtatcgata aggggtacaa
     5461 attcccacta agcgctcggg accccttgta ggaaaatgtc ctaagtggga tatctgtcaa
     5521 ctggtatggt tgactaaaaa tacttcctac gaaaatgtag ggggtatttt tttacgaaaa
     5581 aatacaatcg attcttaaaa agaaaaattt ttgattggca aaaccataac aagttcgttt
     5641 tagggttttg attttgcgat tgatgccttc taaaggacca ttagagtatt caaatttagc
     5701 gctatttaag acatattttc tgttttgacg aagggtttga atagcagtat ccatttctgt
     5761 attggttttt tggtagtcta agatggttga ctctagtaat tcactattgc gctcgtttag
     5821 ggctttcgtg atatcttggt aagtttggta tacttcagcg aacttggaaa atttactagt
     5881 aatgagatca acagcatttt ggcgagtcat atattgttta acgccgcgaa gaaaaactac
     5941 ttcttcaggg tgaagatctt cagctttttt atggaatagc ttccaatgtg acttcataat
     6001 tttatattct tggctctgtt tatcaagttg ctttaggata gagatacgac aattgtccaa
     6061 agcgcgacca gctaattgta caaggtggaa gcgatcaata atgatattgg cattagggaa
     6121 aaggcgatag ataaaacttt gatattgagc atttaaatca attacaactg attgaacgca
     6181 ttcgcgttcg gcttttgaat aacgactttc aaaataatca acaatggtag gtgatagacg
     6241 atcctgtaac tttgtgacaa tttggtgggt ttcagcgtca caacagataa aggacatcac
     6301 agacttaatt gaacgaaact cgtcaaaaca tagatgctta ggcaacttag ccacacgata
     6361 gtgtggttcc atgcgctcta agattgttcg acgaacactg ctaggagagc agtgacacat
     6421 ttcagcaata agctgaccag ataagccttt acgagctaaa agcatgattt gatttttgag
     6481 atcactggat aaggtttgat tttctttggt taaattagta atagcaccaa aagtagtatg
     6541 gcatgattta catttatagc gttgtttacg aagctctagt tcatatcttc tcccatttaa
     6601 acttgccagt cgtacatgag ttttgcgaaa gccatcctta ttaactgtgg gaaagccaca
     6661 gttacgacaa cgattaatcg gataagaaag agtagctgtt attagcgtta tatactcttt
     6721 aacagaatcg ttgttgtgtt cagcttcttc aacagaaata attttaatat ttttatcttt
     6781 aattccaaga atatttagga tagaatcatt atgggacatt tgtttaacct tctttcatga
     6841 tttttgtggt gaattgattg tataacgagg ggacagcaaa tgtcctcttt tttgtataaa
     6901 aaaatctggc atggaatctc tatccatacc agaaagtgta taccccaaaa aaataactca
     6961 aatacaaatt cattgaatat agagaggaga acatttttat gaattttgga caaaaccttt
     7021 ataactggtt tctatcaaac gctcaatcac tggtgctttt agcaatcgtt gtgattggct
     7081 tgtatcttgg cttcaagcgt gagtttagca aactgattgg ctttttaatt attgcgatta
     7141 ttgcggttgg cttagtcttc aacgctgctg gagtaaaaga cattttacta gagctattca
     7201 atcgcattat tggtgcttaa ataaaaccgt tcttttgtgg aatataagtg gttttcttat
     7261 gttccgcaaa ggaatggtac accaaacgaa gtgcggtagg gatttttgaa tctctacaaa
     7321 gaaaggacgt gaatatatgg acgatatgca agtctatatt gcgaatttag gcaaatacaa
     7381 tgagggcgaa ttggtcggtg cgtggtttac ctttcccatt gactttgagg aagtcaaaga
     7441 gaaaatcggc ttgaatgatg aatatgagga atacgccatt catgactacg agttaccctt
     7501 tacggttgac gaatacactt ccattggcga actcaatcga ctatgggaaa tggtatcgga
     7561 attacccgaa gaattacaat cggagctatc tgctctgctc actcattttt caagcattga
     7621 agaactaagc gaacatcaag aggatattat cattcattcc gattgtgatg atatgtatga
     7681 cgtggcacgc tactacattg aagaaacggg tgctttaggc gaagtaccag ctagtcttca
     7741 aaactatatt gattatcaag cctatggtcg ggatttagac ctttcaggaa cgtttatctc
     7801 aaccaatcat gggatttttg aaatcgtcta ttaaatctgt cggtacatta ctactggcag
     7861 attttctatt ttacggggtg gctcaatcag ctacccctat tttttatgaa aggattgatt
     7921 acatgaagaa aatacgaagc tataccagta tctggtctgt ggaaaaggta ctgtattcta
     7981 tcaatgattt tagacttccg tttcccataa cctttacgca aatgacatgg tttgtcgtgt
     8041 cactctttgc agtgatgata cttggcaact tgccccctct ttccatgata gagggagcat
     8101 ttctcaaata ctttgggatt cctgtggctt tcacatggtt tatgtctaca aaaacttttg
     8161 atggtaaaaa gccttatgga tttttgaagt ctgtcattgc ttatgcactg cgaccaaagc
     8221 tgacctatgc aggaaaaaaa gtaacgcttg gcagaaacca gccacaagaa gccattacag
     8281 cagttaggag tgaattttat ggcatatcca attaaataca ttgaaaacaa tctcgtctgg
     8341 aataaagacg gggaatgtta tgcttactat gagcttgttc cttacaatta ctcatttcta
     8401 agtccagaac agaaaataca agtgcatgat tctttcagac agcttatcgc acaaaatcgt
     8461 gatggcaaaa ttcatgcttt acaaatcagt acagaatcca gcatacgttc tgcacaagag
     8521 cgttccaaaa atgaagtcac tggcaagctc aaagcggttg cctatgacaa aatcgaccaa
     8581 cagacagacg ctttaatatc catgattggc gaaaatcaag tgaactaccg tttctttatc
     8641 ggctttaagt tgcttctcaa cgatcaggag ttttctatga aaagtcttac cgttgaagca
     8701 aaaaatgctt tgtctgattt tgtctatgat gtgaaccata agctgatggg cgattttgtt
     8761 agtatgagta atgatgaaat cctgcgtttt cagaagatgg aaaagctctt agaaaataaa
     8821 atctctcgtc gtttcaaaat ccgcaggtta gataaggacg acttcggcta tctgattgaa
     8881 cacctttacg gacagacagg cactgcctat gaagagtatg agtaccatct atcaaagaaa
     8941 aagctggata atgaaacgct gattaaatac tatgacttga ttaagcctac tcgctgtttg
     9001 gtggaagaaa aacagcgata tttgaaaatc cagcaggaag atgaaaccgt ctatgtagct
     9061 tactttacca ttaacagcat tgtcggagaa ctggacttcc cgtcctctga aatcttctac
     9121 taccagcaac agcaatttac attcccgatt gatacgtcaa tgaatgtgga aattgtagcg
     9181 aatcgtaaag ccctatctac tgtccgcaat aaaaagaaag aactgaaaga cttggataac
     9241 cacgcttggc aaagtgataa tgaaaccagc tccaatgtgg cggaagctct ggaaagtgtg
     9301 aatgagctgg aaaccaattt agaccaaagc aaggaatcta tgtacaagct gtcttatgtg
     9361 gtaagggtat cagcaaatga tcttgacgaa ctcaaacgtc gttgtaatga agtgaaagat
     9421 ttttatgacg atttaagcgt aaaactggta cgaccatttg gggatatgct cggcttacat
     9481 gaagaatttt tacctgccag caagcgttat atgaatgatt atattcaata cgtgacctct
     9541 gatttcctcg ctggtttagg ttttggtgct actcaaatgc tgggggaaaa tgaggggatt
     9601 tatgttggct acagcttaga tactggacgc aatgtctatc tgaaacctgc tcttgccagt
     9661 caaggggtta agggttcagt aaccaatgcg ttagcgtcgg cttttgttgg ttcgctgggt
     9721 ggtggtaaat cctttgcgaa taaccttatc gtctattatg cggtgcttta tggggcacaa
     9781 gcagtgattg tagacccaaa agcagaacgt ggcagatgga aagaaacctt gccagagatt
     9841 tcccatgaaa tcaatatcgt cactctgact tctgatgaga aaaacaaagg cttacttgac
     9901 ccttatgtga ttatgaaaaa tcccaaagat tctgaatcac tggctattga tattctcatt
     9961 ccttacgggg atttcctctc gtgatgggga acgcttccca atccttagaa aagccattcg
    10021 tgcagtaacc aatagtgaag tacgagggtt gatgaaagtg attgaggaat tacgggttga
    10081 gaatacgcca ctaagtacca gtatagccga ccatatcgaa agttttacag actatgactt
    10141 tgcacattta ttattcagta atggttatgt ggagcagtct atcagcttag aaaaacaact
    10201 gaacattata caggttgcgg acttggtact tcccgacaag gaaacttcct ttgaggaata
    10261 taccactatg gagcttttat ccgttgctat gctgattgtc attagtacct ttgctttaga
    10321 ctttatccat acagaccgaa gcattttcaa gattgtagat ttagacgaag catggagctt
    10381 tttacaggta gcacaaggaa aaacactatc tatgaagctg gttcgggctg gtcgtgctat
    10441 gaacgctggg gtatatttcg tgacccaaaa tacagacgac ctcttagatg aaaaactgaa
    10501 aaataacctc ggcttaaaat ttgcatttcg ttccactgac cttaacgaga ttaaaaagac
    10561 cttagccttt tttggtgtag acccagagga cgaaaacaat cagaagcgat tgcgtgattt
    10621 ggaaaacggg caatgcctta tcagtgattt atatggtcgt gtcggtgtga tacagttcca
    10681 ccctgtattt gaagaactgc tccatgcctt tgataccaga ccacctgtgc gaaaagaggt
    10741 gtaaatgtga aaccatcaat agtaaacaga ataaaatcaa actggacgct gaaacgtcta
    10801 ggtaaagtgg caatgacagt ggctttcaca cttgtgattg ccatttttct tttagccatg
    10861 ctgggaacgg tggttcaagc tgcgggcttg gtagatgata cggtcaatgt ggcaaatgaa
    10921 tacagccgat acccacttga aaactatcaa ctggattttt atgtggataa tagctggggc
    10981 tggcttccgt ggaactggtc ggacgggatt ggaaaacagg tcatgtatgg actatatgcc
    11041 attaccaatt ttatttggac aatcagtttg tatgtttcca atgcgacagg ttacttagta
    11101 caggaagcct attccttaga cttcatttcc gctacagcag attccattgg taagaatatg
    11161 cagaccttag ctggtgtgag tgcaaacgga ttttcaacag agggtttcta tgttggattc
    11221 ctcttactct tgattttggt tcttggggtt tatgttgcct atacgggact gataaagaga
    11281 gaaaccacaa aggcaattca tgccattatg aattttgtgc tggtgtttat cctatcggct
    11341 tcctttattg cctacgctcc cgactacatt aaaaaaatca atgacttttc atcagacatc
    11401 agtaatgcca gtttatcact tggcacgaag attgtcatgc cccattccga tagtcaaggc
    11461 aaggacagcg tggacttaat cagagatagc ctgttttcca tacaggttca gcaaccgtgg
    11521 ctactgcttc aatacaacag ttcagacatt gaaagtatcg gtattgaccg tgtggaaagc
    11581 ctgctctcca ccagcccaga ttccaacaat ggcgaagaca gagaaaaaat tgttgcggaa
    11641 gaaattgaag acagaagcaa taccaatcta accattacaa agaccattaa ccgtttaggt
    11701 acagtcttct tcctatttgt cttcaatatt gggatttcca tatttgtatt cctattaaca
    11761 ggaatcatga ttttctcgca ggtacttttt atcatctatg ctatgtttct gcctgtgagc
    11821 tttattttaa gcatgattcc atcatttgat ggtatgtcaa aacgagccat aacaaagctc
    11881 tttaatacca ttttgacacg agctggaatc acattgatta ttacgacagc atttagtatt
    11941 tcaaccatgc tctatacctt atcggctggt tatccgttct ttttgattgc ttttctacag
    12001 attgtgacct ttgcaggaat ctacttcaag ctgggcgatt taatgagtat gttttctcta
    12061 cagagtaacg attctcaaag tgtgggaagt cgtgtgatga gaaaacctcg tatgcttatg
    12121 cacgctcaca tgcaccgtct acagcggaaa cttggacgtt ccatgactac tctaggggct
    12181 gggtctgcca ttgttacagg taaaaaagga cagtcgggtt cggggagttc tgcaaggaca
    12241 caagcagatc actcccgacc agacggaaag gaaaaatcaa cacttggaaa acgtatcggt
    12301 caaaccatcg gtacagtagc tgataccaaa gacagaatgg tagacactgc tagtggtttg
    12361 aaagaacagg ttaaagattt gccgaccaat gcaagatatg cagtatatca aggaaaatcc
    12421 aaagtaaaag agaatgtccg tgatttaacc agtagtattt ctcaaaccaa agcggacaga
    12481 gccagtggac gcaaggaaca gcaggaacaa aggcgaaaaa ccattgcgaa gcgtcgctct
    12541 gaaatggaac aggtcaaaca gaaaaaacag cctgcttctt ctgttcatga aagaccgact
    12601 acaagacaag aacaatatca tgatgaacag acctcaaaac agtctaatat tcagacttca
    12661 tataaggaat ctcaacaagc caaacaagag cgtccagcag ttaagtccga tttttcaagt
    12721 ccaaaagtgg aacgccaagg caataccgtt caagaaaaaa ccgttcaaaa gccagcaact
    12781 tcaaccacta cagcagatag aacttcacaa cgtccaatca caaaagaacg tccgtctact
    12841 gttcaaagag taccactaca aaatacaaga agtagaccac caatcaaaac cgccaccatt
    12901 aagaaagtcg gtaagaaacc atgaagttga aaactttagt gattggtggt tctggattat
    12961 tcttgatggt cttctcactg cttctgtttg ttgccatttt attttcagat gaacaggaca
    13021 gcggaatttc caatattcat tatggaggtg tgaatgtttc cgcagaagtg ctggctcata
    13081 agcctatggt agaaaaatat gccaaagaat atggcgttga agaatatgtc aacatacttc
    13141 ttgcgattat acaggtggaa tcgggcggta ctgcggaaga tgttatgcag tcctcggaat
    13201 ccctcggtct tccacctaat tcattgagta cagaagaatc cattaagcaa ggtgtgaagt
    13261 atttcagtga attattagcc agtagcgaaa ggctcagtgt agatttagaa tcggttatcc
    13321 agtcctacaa ttatggtggt ggtttcttag ggtatgtggc taatcgtgga aataaatata
    13381 cctttgaact ggctcaaagt ttctcaaaag agtattcagg tggcgaaaaa gtgtcttacc
    13441 ccaatcccat agccatacct atcaatgggg gctggcgata caactatggc aatatgtttt
    13501 atgtgcaact ggtaacgcag tatcttgtca caacagagtt tgatgatgat acggtacaag
    13561 ccatcatgga cgaagcactg aaatatgagg gctggcgata cgtttacggt ggagcttccc
    13621 cgactacttc ttttgattgt agcggactga cacaatggac gtatggaaaa gctggaatta
    13681 acttaccacg aaccgcacaa cagcaatatg atgtgaccca gcatatccca ctatcggaag
    13741 cacaagctgg cgatttggtt ttctttcatt ctacctataa cgctggctct tatattactc
    13801 atgttgggat ataccttggc aataaccgta tgtttcatgc aggcgaccca atcggttatg
    13861 ccgacttaac aagcccctac tggcaacagc atttagtggg agcaggacga atcaaacaat
    13921 gagaaaggaa gatttaatga tgaaatttag aaaaaatcag aataaagaaa aacagatacc
    13981 aaaggaaaag aaacctcgtg tctactataa ggtcaatcct cataaaaagg ttgtgattgc
    14041 cttgtgggta cttttagggc ttagtttcag ctttgcgata ttcaagcact ttacagctat
    14101 agatactcat actattcacg aaacaactat catagaaaag gaatacgttg atactcatca
    14161 tgtagaaaat tttgtagaga actttgcgaa agtctactat tcatgggagc aatccgataa
    14221 gtccattgat aatcgaatgg aaagtctaaa aggctatctg acagatgaac ttcaagctct
    14281 caatgttgat acagtacgca aagatattcc tgtatcgtct tctgtaagag gatttcagat
    14341 atggacggta gagccaactg gcgacaatga gtttaatgta acctacagtg tagaccagct
    14401 cattacagag ggagaaaata caaagaccgt ccactctgct tatatagtga gtgtctatgt
    14461 agatggttct ggaaatatgg tactggttaa gaatccgacc attaccaaca tacctaagaa
    14521 atcaagttat aaaccaaaag ccattgaaag tgaggggacg gttgattcca ttacaaccaa
    14581 tgaaatcaat gagtttttaa cgacgttctt caagctctat cctacagcga cagccagtga
    14641 actttcctac tatgtgaatg acgggatatt aaaaccaatc ggaaaagagt acatctttca
    14701 agaactggta aatcctattc acaatcgtaa ggataatcaa gtcacggtat cgctgacagt
    14761 ggagtatatc gaccagcaga ccaaagcaac gcaggtatct caatttgatt tggtacttga
    14821 aaagaacggg agtaattgga agattataga ataacaaata ttggtacatt attacagcta
    14881 ttttgtaatc acgtactctc tttgataaaa aattggagat tccttgacaa atatgctctt
    14941 acgtgctatt atttaagtat ctatttaaaa ggagttaata aatatgcggc aaggtattct
    15001 taaataaact gtcaatttga tagtgggaac aaataattgg atgtcctttt ttaggagggc
    15061 ttagtttttt gtacccagtt taagaatacc tttatcatgt gattctaaag tatccggaga
    15121 atatctgtat gctttgtatg cctatggtta tgcataaaaa tcccagtgat aaaagtattt
    15181 atcactggga tttttatgcc cttttgggtt tttgaatgga ggaaaatcac atgaaaatta
    15241 ttaatattgg agttttagct catgttgatg caggaaaaac taccttaaca gaaagcttat
    15301 tatataacag tggagcgatt acagaattag gaagcgtgga caaaggtaca acgaggacgg
    15361 ataatacgct tttagaacgt cagagaggaa ttacaattca gacaggaata acctcttttc
    15421 agtgggaaaa tacgaaggtg aacatcatag acacgccagg acatatggat ttcttagcag
    15481 aagtatatcg ttcattatca gttttagatg gggcaattct actgatttct gcaaaagatg
    15541 gcgtacaagc acaaactcgt atattatttc atgcacttag gaaaatgggg attcccacaa
    15601 tcttttttat caataagatt gaccaaaatg gaattgattt atcaacggtt tatcagaata
    15661 ttaaagagaa actttctgcc gaaattgtaa tcaaacagaa ggtagaactg tatcctaata
    15721 tgtgtgtgac gaactttacc gaatctgaac aatgggatac ggtaatagag ggaaacgatg
    15781 accttttaga gaaatatatg tccggtaaat cattagaagc attggaactc gaacaagagg
    15841 aaagcataag atttcagaat tgttctctgt tccctgttta tcacggaagt gcaaaaaaca
    15901 atatagggat tgataacctt atagaagtga ttacgaataa attttattca tcaacacatc
    15961 gaggtcagtc tgaactttgc ggaaaagttt tcaaaattga gtattcggaa aaaagacagc
    16021 gtcttgcata tatacgtctt tatagtggcg tactgcattt gcgagattcg gttagaatat
    16081 cggaaaagga aaaaataaaa attacagaaa tgtatacttc aataaatggt gaattatgta
    16141 aaattgataa ggcttattcc ggggaaattg ttattttgca gaatgagttt ttgaagttaa
    16201 atagtgttct tggagataca aagctattgc cacagagaga gagaattgaa aatcccctcc
    16261 ctctgctgca aacgactgtt gaaccgagca aacctcaaca aagggaaatg ttacttgatg
    16321 cacttttaga aatctccgac agtgacccgc ttctgcgata ttatgtggat tctgcgacac
    16381 atgaaatcat actttctttc ttagggaaag tacaaatgga agtgacttgt gctctgctgc
    16441 aagaaaagta tcatgtggag atagaaataa aagagcctac agtcatttat atggaaagac
    16501 cgttaaaaaa agcagagtat accattcaca tcgaagttcc accgaatcct ttctgggctt
    16561 ccattggtct atctgtagca cagcttccat tagggagcgg agtacagtat gagagctcgg
    16621 tttctcttgg atacttaaat caatcgtttc aaaatgcagt tatggagggg atacgctatg
    16681 gctgtgaaca aggattgtat ggttggaatg tgacggactg taaaatctgt tttaagtatg
    16741 gcttatacta tagccctgtt agtaccccag cagattttcg gatgcttgct cctattgtat
    16801 tggaacaagt cttaaaaaaa gctggaacag aattgttaga gccatatctt agttttaaaa
    16861 tttatgcgcc acaggaatat ctttcacgag catacaacga tgctcctaaa tattgtgcga
    16921 acatcgtaga cactcaattg aaaaataatg aggtcattct tagtggagaa atccctgctc
    16981 ggtgtattca agaatatcgt agtgatttaa ctttctttac aaatggacgt agtgtttgtt
    17041 taacagagtt aaaagggtac catgttacta ccggtgaacc tgtttgccag ccccgtcgtc
    17101 caaatagtcg gatagataaa gtacgatata tgttcaataa aataacttag tgtattttat
    17161 gttgttatat aaatatggtt tcttgttaaa taagatgaaa tattctttaa taaagatttg
    17221 aattaaagtg taaaggagga gatagttatt
//
LOCUS       DBERMM010000041        16887 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.043, whole genome shotgun sequence.
ACCESSION   DBERMM010000041 DBERMM010000000
VERSION     DBERMM010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 16887)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16887)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16887
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.043"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            345..1790
                     /gene="cps4A"
                     /locus_tag="ACL8AS_001684"
     CDS             345..1790
                     /gene="cps4A"
                     /locus_tag="ACL8AS_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4A"
                     /protein_id="HGS1229505.1"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIIDSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIEDVMEGR"
     gene            1792..2523
                     /gene="cps4B"
                     /locus_tag="ACL8AS_001685"
     CDS             1792..2523
                     /gene="cps4B"
                     /locus_tag="ACL8AS_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4B"
                     /protein_id="HGS1229506.1"
                     /translation="MIDVHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKSKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFVDNPRKIIMDQLI"
     gene            2532..3224
                     /locus_tag="ACL8AS_001686"
     CDS             2532..3224
                     /locus_tag="ACL8AS_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000664160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein"
                     /protein_id="HGS1229507.1"
                     /translation="MEEQNTLEIDVLQLFRSLWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVNRDQGEKSGLTNQDLQAGTYLVKDYREIILSQDVLEEVVSDLKLD
                     LTPKGLANKIKVTVPVDTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDVT
                     TLEEARPATTPSSPNVRRNTLFGFLGGAVVTVIAVLLIELLDTRVKRPEDVEDVLQIP
                     LLGLVPDLDKMK"
     gene            3234..3923
                     /locus_tag="ACL8AS_001687"
     CDS             3234..3923
                     /locus_tag="ACL8AS_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase"
                     /protein_id="HGS1229508.1"
                     /translation="MPTLEISQAKLDFVKKAEEYYNALCTNLQLSGDGLKVFSITSVK
                     LGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            3938..5305
                     /locus_tag="ACL8AS_001688"
     CDS             3938..5305
                     /locus_tag="ACL8AS_001688"
                     /EC_number="2.7.8.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HGS1229509.1"
                     /translation="MNGKIVKSSLAIIQSFLVILLTYLLSAVREAEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRGYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LTLHALLVYVLNLFIKWYWKRAYPNFKGSKKILLLTATSRVEKVLDRLIESNEVVGKL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIVGALVGLIL
                     CGLASIVLVPLIRKDGGSTIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVFM
                     RDGAK"
     gene            5309..5758
                     /locus_tag="ACL8AS_001689"
     CDS             5309..5758
                     /locus_tag="ACL8AS_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017650132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--LPS N-acetylglucosamine
                     transferase"
                     /protein_id="HGS1229510.1"
                     /translation="MKICLVGSSGGHLTHLYLLKPFWKDKERFWVTFDKADARSVLSE
                     EVVYPCYYPTNRNIKNLIKNTFLAYKILKKERPDLIISSGAAIAVPFFYIGKLFGSKT
                     VYIEVFDRIDASTLTGKLVYPVTDRFIVQWEEMKKVYPKAINLGGIF"
     gene            5758..6264
                     /locus_tag="ACL8AS_001690"
     CDS             5758..6264
                     /locus_tag="ACL8AS_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000578432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HGS1229511.1"
                     /translation="MIFVTVGTHEQQFNRLIKEVDRLKGEGFIQDDVFIQTGYSNYVP
                     KFCKWEKLISYEKMNQFIEEADTIITHGGPATFMAVIAKGKSPIIVPRLKKFGEHVND
                     HQLEFVEKVLNVYNLTVITNISDLNSYISNFDERKKSDLKSKNNLFMEKFIDMINQLM
                     ETGDIKYD"
     gene            6257..7456
                     /locus_tag="ACL8AS_001691"
     CDS             6257..7456
                     /locus_tag="ACL8AS_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-carotene 15,15'-monooxygenase"
                     /protein_id="HGS1229512.1"
                     /translation="MTKYINSCIKLLFIYSLFSELLYSYYSVSLLFTIPDLLLLAAAV
                     IVFVDSYSAGKIRVKNPHISLMLFFILLIFLLISFTWGTLNIYGFVMRGRYILGAFLV
                     YFMTNSYLDDRTFSSLINIAYFMQILNLLLVLHQNIVLHLHPDFTNGIFGFTNYANGI
                     QGFYCLALSVLSTVYYLYGKWGTMKSLILIAISCIICALAEIKIFFVIFIFSIILIFI
                     FQKSETVKKIRIISTAAGISLLFLIAYKLIEIVLPDNLYTFFNVTKALSYENRTEFAG
                     RTNTISFLWDNLFYHDYISAIFGKGLGSYSVNYIYELGKMLADGGFISVILLYSFLLS
                     LFIRGTITRGKNKQSERLIVSIIAFVVMISIIVWNSTFTRSTYLVFFFLAIGNAAYKS
                     TKLIRRD"
     gene            7458..8486
                     /locus_tag="ACL8AS_001692"
     CDS             7458..8486
                     /locus_tag="ACL8AS_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1229513.1"
                     /translation="MEIQISVVIPVYNAENTINNCIESALKQDLESFEVILVNDGSND
                     STSRILEQYSDNPQVKIFHQVNMGVSAARNLGLSHASGEYVFFLDSDDILDDGMLSKM
                     YQFVKNNKVDLLSCWHKEPATTQYGGNENKSTSFIARTREEIGAHFVDIFPRSACAKL
                     FFRKIIEENNITFSTEMSLGEDMSFVYQYLMVSKSIGVIDGVYYNIQNVNPQSLSKRY
                     VQNIENSLMIQNQLWNQLLEVYPKIEENYYKQHMDFRFYLANLYVNNLFKFDSPYSSK
                     EKLDQIAQQLKKYRLFLDEKVSKEKMPKNINEMIVFYLLKLKIPVLIYSFYSFKEWWK
                     RRKIKNEG"
     gene            8494..9450
                     /locus_tag="ACL8AS_001693"
     CDS             8494..9450
                     /locus_tag="ACL8AS_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1229514.1"
                     /translation="MEDLISIVVPVYNVEKYLKKSIESVLNQTYQNIEILLVDDGSTD
                     SSGKICESFSKVDPRIRVFHKENGGLSDARNFGIEQMKGQYVAFIDSDDYISKDYVWK
                     LYSSIKNNDSEVSICSFLLVDEKGEKIKDELLDSGKICLTGQQILEKVLTADGYRYVV
                     AWNKLYRSTLFEKLKFKKGMLYEDEFLNYPLFWDCKRVSIVEEPLYLYVQRKGSIVQS
                     NMTLEKIKMKDEMHTSRIEFYSEKGHSFLHEKACQQYCNWIVTATTNHSKILNPNFSK
                     YLQRQFRKFAKYTRNNDIRLIVQNILGFIDIRLAAYVKSKVM"
     gene            9466..10374
                     /locus_tag="ACL8AS_001694"
     CDS             9466..10374
                     /locus_tag="ACL8AS_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000570495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide synthesis protein"
                     /protein_id="HGS1229515.1"
                     /translation="MIEKILDSIKNHSFYSKLKDKIHRIIPLYIIKNQNIAFQQDTDI
                     AYRKLKKKFRHISLTGDELKYKMEFSNKVWICWFQGEEHAPELIKTCIQSMRNQLQGR
                     EIIVLTEKNISDYTEIPGYIIEKYKKGWISRAHYSDILRIDLLCRHGGLWVDATVLNT
                     GGDFSNLEVPLFVYKSLNLSRKDSQAIVASSWLISSYSNHPILLYTRKLLWAYWRRKN
                     SLCNYFLFHICFTIATERYPIEWSAVPTFNNHSPHILHFELNEQFSEKRWEQLKHISA
                     FHKLNHHIDYSSGVNTFYKFIVSSKV"
     gene            10379..11842
                     /locus_tag="ACL8AS_001695"
     CDS             10379..11842
                     /locus_tag="ACL8AS_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000066237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0140327 - flippase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="HGS1229516.1"
                     /translation="MSNKISKNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSF
                     TMSVALYFMMFMLLGIANYGNRTIATVKREGKDILSKTFWSIYSIQLIMSILVTIAYL
                     AYLYLGAVHYKVIAILQLFLLLSNAVDITWFFYGLENFKQIVFRNTLVKLLGLFLIFL
                     CVRQGTDLWKYTFINGSVTLVGQLLLWGQLKGILTWKKIQLKELLPHIKPILILFIPV
                     LAISIFTNMDKYMLGLMVDVKQVGFYDNAGRIIEIPKALIAALGAVMLPRTSYLLAEG
                     QKEKSKYYIEVTILYVMIISSVLMFGLISVSDIFSIIFWGEEFLESGRLISAMSPAFV
                     FSVLGNIIRTQYLIPRAKDKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEF
                     VLSGMQFWSVRRDLDLKRYLKNGLIFYLFGLIMYLVIITLKTQLPYNIMSLILLIVLG
                     GIVYVIFCCCYILMSRNLHFKLLKEKIIRKVVHKNTL"
     gene            12200..12445
                     /locus_tag="ACL8AS_001696"
     CDS             12200..12445
                     /locus_tag="ACL8AS_001696"
                     /inference="COORDINATES: protein motif:HMM:NF013884.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase family protein"
                     /protein_id="HGS1229517.1"
                     /translation="MVTKDKGLTYNSTLHAIKVLACFSVVAIHIWLPGKIGAFYQIIA
                     RFAVPMFFLISGFYSYNISKNRIKKIFRLILRSTFFM"
     gene            12534..13034
                     /locus_tag="ACL8AS_001697"
     CDS             12534..13034
                     /locus_tag="ACL8AS_001697"
                     /inference="COORDINATES: protein motif:HMM:NF013884.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase family protein"
                     /protein_id="HGS1229518.1"
                     /translation="MLLLFSFIMEATISDSIFYRNFLFMGIPFFGIGILIAQNQKKII
                     NCKIINKILILGTIIYPILIFLEYYILGNSFEVYISSVLATIILMIFAIKSPKAINIK
                     ILNGIGDKYATFVYIIHQFIIVIFKFLVSNVYILKFGTIFVFLICCFLGVLFQFIKNR
                     LLKRFS"
     gene            13036..14184
                     /locus_tag="ACL8AS_001698"
     CDS             13036..14184
                     /locus_tag="ACL8AS_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000636508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol--glycerophosphate
                     glycerophosphotransferase"
                     /protein_id="HGS1229519.1"
                     /translation="MVVLQNVKFLVRVVFMVIISIVLWPVRIKKNKILFINFNGKGYG
                     DNPKSICEYLRVTYPELDLVWLAKDNEDFPDGVRVVRYKSLQSFYEQASSKVWVYNVR
                     NFERLLKKRGQFYIQTWHGASSFKLIEKQADLPLKYILEAKYDARVTDIMISDSRKQT
                     EEFQKYFWYSGEIFEVGMPRNDALFHYKEDYDKLNNIRKELSIDSDDYVILYAPTFRD
                     DGDASYLDINFERLLQSIEQEIKKKCKILIRLHPNDSHFSNNISFNHDIIDVTLFSDM
                     QELILLADVLLTDYSSAIFDFMLLNKPYVRYVNDLEKYAELRGLSDTYYELPDPIIKT
                     AEELYDLLPKKIENFDYDSIKKYRNEILCPIFNGTASENVGRRIIQEL"
     gene            14220..15248
                     /locus_tag="ACL8AS_001699"
     CDS             14220..15248
                     /locus_tag="ACL8AS_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000794266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="HGS1229520.1"
                     /translation="MKNNDLKIGSGAIHQISATLSQNNISGKILYCADPVVDDLYGSI
                     VRSQIEEIGRVKEESCNYNTIAYAMNIAERAIATDIDCIVGMGGGRVLDVCKYASFIS
                     KRPYLSIPTTAANDGIASPVAVLKRQDDRPKSLGAAIPSMTLIDIDVIASGPIQNIKA
                     GIGDTISNYTALKDWELAVERGKDEMHGFAYLMSQNSLDALMKTKYNSITPDFIEVLV
                     NSLVLSGIAMDFAGSSRPVSGSEHLFSHALDYYGSTRNLHGIQVALGTVAVLKLIENS
                     VDAVVDYLQRFEVHINPKLLGIDEELFIYCMQHATKMRSNRYTYLHEVDLSTDRLKQI
                     YKELISEL"
     gene            15264..15968
                     /locus_tag="ACL8AS_001700"
     CDS             15264..15968
                     /locus_tag="ACL8AS_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="HGS1229521.1"
                     /translation="MKALILAAGLGTRLAPITNEVPKSLVPVNGKPILMKQIENLYQN
                     NITDITIIAGYKSSVLTDAVTEKYPEINIIDNVDFKTTNNMYSAYLGKAAMGDSDFLM
                     MNADVFYDASVIKSLLLHKAPNAIVTDLGTYIEESMKVVEKNGRLVEISKQISPEEAL
                     GASIDVYKFSYEAGARFFEKCKEFIEDKRELQMWSEVALNAILPEVEFIACPLDGRWL
                     EIDNHEDLAVAEKLFA"
     gene            15983..16816
                     /locus_tag="ACL8AS_001701"
     CDS             15983..16816
                     /locus_tag="ACL8AS_001701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000779205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IIA family hydrolase"
                     /protein_id="HGS1229522.1"
                     /translation="MKLTNRVDYFGADISELQNKKLFLFDMDGTIYEEDRLFEGTLEL
                     LDYIHNIGGEYIFITNNSSKSVVDYVEKVNRLGIKAERDNFFTSAQATIVYIKENYPK
                     SKVYCQGTKSLIKELSDAGIDVTEQVSADIDVVLVGFDTELTSDKIRNTCEILSTKDV
                     PFIATNPDIRCPVSFGFIPDCGSICDMISKSVDRKPVYIGKPEPTMVDIVRKKLNYSL
                     FETVVIGDRLYTDIMTGINAGVTSVCVLTGEATVNDIQQGSIKPTYTFKNVKEMWKGI
                     V"
BASE COUNT         5593 a         2294 c         3316 g         5684 t
ORIGIN      
        1 gcgaccatat tctcgataaa aataagtatc gaatcctgtt tcgtcaatct aaacaggtgc
       61 taggtgcttt aaactattaa aattcttaag aaataaggct actttttctg ggtcttgttc
      121 ataattagat tgaaactaga atagtacacc tctgcttcta aaacattgtt agaaatcgat
      181 ttgactgtcc tgatcgattt gtcatgttct tatttcattt tactatattt ttgtttcgcg
      241 ggaagtctac taagatactt aaagatgcag atagtaaaaa aaatgtagac attaccgtaa
      301 aaaagtgata taatcgtatg atgttcaagg tataggtgtt aatcatgagt agacgtttta
      361 aaaaatcacg ttcacagaaa gtgaagcgaa gtgttaatat cgttttgctg actatttatt
      421 tattgttagt ttgtttttta ttgttcttaa tctttaagta caatatcctt gcttttagat
      481 atcttaacct agtggtaact gcgttagtcc tactagttgc cttggtaggg ctactcttga
      541 ttatctataa aaaagctgaa aagtttacta tttttctgtt ggtgttctct atccttgtca
      601 gctctgtgtc gctctttgca gtacagcagt ttgttggact gaccaatcgt ttaaatgcga
      661 cttctaatta ctcagaatat tcaatcagtg tcgctgtttt agcagatagt gatatcgaaa
      721 atgttacgca actgacgagt gtgacagcac cgactgggac tgataacgaa aatattcaaa
      781 aactactagc tgatattaag tcaagtcaga ataccgattt gacggtcgac cagagttcgt
      841 cttacttggc agcttacaag agtttgattg caggggagac taaggccatt gtcttaaata
      901 gtgtctttga aaatatcatc gagtcagagt atccagacta cgcatcgaag ataaaaaaga
      961 tttataccaa gggattcact aaaaaagtag aagctcctaa gacgtctaag aatcagtctt
     1021 tcaatatcta tgttagtgga attgacacct atggtcctat tagttcggtg tcgcgatcag
     1081 atgtcaatat cctgatgact gtcaatcgag ataccaagaa aatcctcttg accacaacgc
     1141 cacgtgatgc ctatgtacca atcgcagatg gtggaaataa tcaaaaagat aaattaaccc
     1201 atgcgggcat ttatggagtt gattcgtcca ttcacacctt agaaaatctc tatggagtgg
     1261 atatcaatta ctatgtgcga ttgaacttca cttctttctt gaaaatgatt gacttattgg
     1321 gaggggtaga tgttcataat gaccaagagt tttcagctct acatgggaag ttccatttcc
     1381 cagtagggaa tgtccatcta gactctgagc aagctctagg ttttgtacgt gaacgctact
     1441 cactagccga tggagaccgt gaccgtggtc gcaaccaaca aaaggtgatt gtggctatcc
     1501 ttcaaaaatt aacgtcaacc gaagcactga aaaattatag tacgatcatt gatagcttgc
     1561 aagattctat ccaaacaaat atgccacttg agaccatgat aaatttggtc aatgctcagt
     1621 tagaaagtgg agggaattat aaagtaaatt ctcaagattt aaaaggtaca ggtcggatgg
     1681 atcttccttc ttatgcaatg ccagacagta acctctatgt gatggaaata gatgatagta
     1741 gtttagctgt agttaaagca gctatagagg atgtgatgga gggtagatga aatgatagac
     1801 gtccattcgc atatcgtttt tgatgtagat gacggtccca agtcaagaga ggaaagcaag
     1861 gctctcttgg cagaatccta caggcagggg gtgcgaacca ttgtctctac ctctcaccgt
     1921 cgcaagggca tgtttgaaac tccggaagag aagatagcag aaaactttct tcaggttcgg
     1981 gaaatagcta aggaagtggc gagtgacttg gtcattgctt acggggctga aatttactac
     2041 acaccagatg ttctggataa gctagaaaaa aagcggattc cgaccctcaa tgatagtcgt
     2101 tatgccttga tagagtttag tatgaacact ccttatcgcg atattcatag cgccttgagc
     2161 aagatcttga tgttgggaat tactccagtc attgcccaca ttgagcgcta tgatgctctt
     2221 gaaaataatg aaaaacgcgt tcgagaattg atcgatatgg gctgttacac gcaagtaaat
     2281 agttcacatg tcctcaaatc caaacttttt ggcgaacgtt ataaattcat gaaaaaaaga
     2341 gctcagtatt ttttagagca ggatttggtc catgtcattg caagtgatat gcacaatcta
     2401 gacggcagac ctcctcatat ggcagaagca tatgaccttg ttacccaaaa atacggagaa
     2461 gcgaaggctc aggaactttt tgtagataat cccagaaaaa ttataatgga tcaattaatt
     2521 taggagaaaa tatggaggaa caaaacactt tggaaatcga tgtattgcaa ctattcagat
     2581 ctttgtggaa aagaaagttg gtcattttat tagtggcaat tataacttct tcagttgctt
     2641 ttgcctacag tacttttgtt atcaaacctg agtttactag tacgactcgg atttatgtag
     2701 ttaaccgtga tcagggagag aagtctggtt taaccaatca agacttgcag gcaggaacat
     2761 acttggttaa agactatcgt gaaattatcc tatcgcagga tgttttggag gaagttgttt
     2821 ctgatttgaa actagatttg acgccaaaag gtttggctaa taaaattaaa gtgacagtac
     2881 cagttgatac ccgtattgtc tcaatctctg tcaaggataa acagccagag gaagccagtc
     2941 gtatcgctaa ttctctacga gaagttgctg cagaaaagat cgtcgctgta acgcgagtat
     3001 ctgatgtaac gacacttgaa gaagcgcgac cagctacgac tccctcttct ccaaatgttc
     3061 gacgcaacac cttgtttggt tttcttggag gagccgtcgt aacagtaatt gctgttcttt
     3121 tgattgagtt gctcgacacc cgtgtgaaac gtcctgaaga tgttgaagat gtactgcaaa
     3181 ttccactttt agggctcgtt ccagatttgg acaaaatgaa ataggaggaa gttatgccaa
     3241 cgttagaaat ctcacaggca aaattggatt ttgtaaaaaa ggcagaggaa tattataacg
     3301 ctttgtgcac gaacctacag ttaagtggag atggtttgaa agtattttct atcacttctg
     3361 tgaaactagg agaaggaaaa tcaacgactt ccaccaatat cgcttgggct tttgcgcgtg
     3421 caggttacaa aacgctgctg attgatggag atattcgcaa ttctgttatg ttaggtgtct
     3481 ttaaagcaag ggataagatt acaggcctga cagaattttt atcaggaact acagacctat
     3541 cacaagggct ttgtgatacc aatatcgaaa atctctttgt aattcaggct ggctctgtgt
     3601 caccgaatcc gacagctctt cttcaaagta agaatttcag tacaatgctt gaaacattgc
     3661 gtaaatattt tgactacatc attgtagata ctgctcctgt cggtgtcgtg attgatgcgg
     3721 ctattattac gcgaaaatgc gatgcttcta ttttagtgac ggaggcaggt gaaataaatc
     3781 gacgggatat tcaaaaagca aaagaacagt tggaacacac agggaagccg tttttgggag
     3841 ttgtgttgaa taaattcgat acttcagtag acaaatacgg ttcttatgga aattatggag
     3901 attacgggaa aaataaaaaa taggtcgggg gatagagatg aatggaaaaa tagtaaagtc
     3961 ttcattggcc ataatccaga gttttcttgt tattttattg acttatctac ttagtgctgt
     4021 gagagaagcg gagattgttt caacaacagc tattgcactt tatatcctcc attattttgt
     4081 cttttatatc agtgattatg gacaggattt ctttaaaagg ggatatttga ttgaacttgt
     4141 ccagacattg aaatatatcc tattctttgc actagcgatt agtatttcta attttttctt
     4201 agaggatcga tttagtattt ccagacgagg catgatttac ttcctcacat tacatgctct
     4261 cttagtctat gtgctaaacc tatttatcaa gtggtattgg aagcgggctt atcccaactt
     4321 taaaggaagt aagaagattc tcctacttac agcaacttct cgtgtcgaaa aggtactgga
     4381 tagattaata gaatcaaatg aggttgttgg gaagttggta gccgtcagtg tcttagataa
     4441 accagatttt cagcatgatt gtttaaaggt agtagcagag ggggagatag taaactttgc
     4501 gactcatgag gtggtcgatg aagtctttat caatcttcca agtgaaaaat acaatattgg
     4561 agagcttgtc tctcagtttg aaacgatggg aattgatgta acagtcaatc taaatgcttt
     4621 tgatcgtagt ttggcacgta acaagcaaat ccgtgagatg gcaggattaa acgttgtgac
     4681 tttttctaca acattttata agactagtca tgtaattgct aagcggatta ttgatatcgt
     4741 gggtgcattg gtagggctga tactatgtgg tctagccagt attgtactgg ttcctttgat
     4801 tcgaaaggat gggggctcta ctatttttgc tcagacgcgt ataggaaaaa atggtcgtca
     4861 gttcactttt tataagtttc gctctatgtg tgtagatgcc gaggcgaaaa aaagagaact
     4921 catggaacaa aataccatgc agggtggaat gtttaaggtg gacgatgatc ctcgtatcac
     4981 gaaaattggt cgttttatac ggaagactag cttggacgag ctaccacagt tttataatgt
     5041 tctaaaggga gatatgagtt tggttggcac acggccacca acagtggacg agtatgaaca
     5101 ctatacccca gaacaaaaac gtcggctaag ttttaaacct ggtataacag gcttatggca
     5161 ggtcagtgga cgaagtgaga ttaagaattt tgatgaagtt gtcaaattag atgtagccta
     5221 tatagacgat tggacaattt ggaaagacat tgaaatttta ttgaagacag ttaaagttgt
     5281 atttatgaga gacggagcga agtaggaaat gaaaatatgt ttagttggat ctagtggagg
     5341 tcatctgact catttatatc ttttaaaacc tttctggaaa gataaagaaa gattttgggt
     5401 tacttttgat aaggcggacg ctcggagtgt actctctgag gaagttgtat atccctgtta
     5461 ttatccaacc aatcgtaata taaaaaattt aataaaaaat acttttctcg cctataaaat
     5521 tttaaaaaaa gagagaccag atttgattat ttcttctggt gccgctatcg ctgttccttt
     5581 cttttatatt gggaagttat ttggatcaaa gacagtgtat atagaagttt ttgatagaat
     5641 tgatgcttca acactgacag gaaaacttgt ttatccagta acggataggt ttattgttca
     5701 atgggaagaa atgaaaaaag tatacccaaa ggcaattaat ctcggaggga ttttctaatg
     5761 atttttgtga cagtaggtac tcatgaacaa cagtttaatc gacttattaa agaggttgat
     5821 agattaaaag gtgagggatt tattcaggat gatgttttta ttcaaacagg atactctaat
     5881 tatgttccaa aattttgtaa atgggaaaaa ttaatatctt atgaaaaaat gaatcaattt
     5941 attgaggaag ctgatacaat cattacccat ggcggtccag ctacgtttat ggcagttatt
     6001 gctaaaggga aaagtccgat aattgttccg agattaaaaa aatttggtga gcatgtgaac
     6061 gaccatcaac ttgaatttgt tgagaaagtg ttaaatgtct ataatttgac agtcatcact
     6121 aacataagtg atcttaattc ctatatttct aattttgatg agcgaaaaaa atcagatttg
     6181 aagagcaaaa ataatctatt tatggagaaa tttatagata tgattaatca gttgatggag
     6241 acaggtgaca tcaagtatga ctaagtacat aaatagctgt atcaagttgt tattcatata
     6301 ttcgttattt agtgaattgc tatactcata ttattctgta tctctattat ttacgatacc
     6361 tgacttatta ttgttggcag cagcagtaat tgtttttgta gattcttatt ctgcagggaa
     6421 aataagagtt aaaaatcctc acattagttt aatgctcttt tttatattgc tgatatttct
     6481 attaattagt tttacttggg gtactcttaa tatatatgga tttgttatga gaggaagata
     6541 tatactggga gcatttctag tttattttat gacaaatagc tatctagatg atagaacctt
     6601 ttcatcattg ataaacattg cttattttat gcagatattg aacctattat tagttttaca
     6661 tcaaaatata gtattacatt tgcaccctga cttcactaat gggatttttg gttttactaa
     6721 ttatgcaaat ggaatccaag gattttattg cttagcctta agtgttttat ctactgtata
     6781 ttatctgtat ggtaaatggg gaacaatgaa gtcattaata ttgattgcta tttcgtgtat
     6841 aatttgtgca ttagcagaaa taaagatttt ttttgtcatt tttatatttt ctattattct
     6901 aatttttata tttcaaaagt cagaaacagt aaaaaaaata cgaataatta gtacagctgc
     6961 tggaatatct cttctttttt taattgccta taaactcatt gagatagttt tacctgataa
     7021 tttgtatact ttttttaatg ttacaaaggc attatcatat gagaatagga cagagtttgc
     7081 gggacgaaca aatactattt ccttcctatg ggacaactta ttttatcatg attatattag
     7141 tgctatattt gggaaaggac taggttcata ctctgttaat tatatttatg aacttggtaa
     7201 aatgcttgca gatggtggtt ttatttcagt gattttgctt tattcatttt tgttgtcatt
     7261 attcatacgg ggaactatta ctagaggaaa aaataagcaa agtgaaagac taattgtatc
     7321 catcatagct tttgtggtga tgattagcat tattgtttgg aatagtacgt tcactagatc
     7381 aacttatctt gtatttttct ttctagcaat aggtaatgca gcgtataagt ctactaaatt
     7441 aataagaagg gattgagatg gaaattcaaa tatcagtggt gattccagta tacaatgctg
     7501 aaaacacgat taataattgt attgaaagtg ctttaaaaca agatttagaa tcttttgaag
     7561 taattttagt aaacgatgga tcgaacgatt ctacatcaag aattcttgaa cagtatagtg
     7621 ataatcccca agtgaagata tttcatcaag tgaacatggg agtatctgct gccagaaatt
     7681 taggtttatc tcatgcaagc ggagaatacg tattcttttt agattcagat gatattttag
     7741 atgatggtat gctttctaaa atgtaccaat ttgtaaaaaa taataaagtt gatctcttat
     7801 cttgttggca taaagaacct gctacaactc aatacggtgg aaatgagaat aagtcaactt
     7861 catttattgc acgtacaaga gaagaaatag gtgctcattt tgttgatatc tttccgagaa
     7921 gtgcttgtgc caaattgttt tttcgcaaaa taattgaaga aaataatatt actttttcga
     7981 ctgagatgtc actaggtgaa gatatgtcat ttgtgtatca atacttaatg gtttctaaaa
     8041 gtattggagt tattgacggg gtgtattata atattcaaaa tgtaaatcca cagtcgttat
     8101 ctaagcgcta tgtgcagaat attgaaaatt ccctaatgat tcagaaccag ttatggaatc
     8161 aactgttgga agtttatcct aaaattgagg agaactacta taagcaacat atggatttta
     8221 gattttacct tgctaacttg tatgtaaata atttatttaa atttgattct ccgtattcat
     8281 caaaagaaaa actagaccaa attgctcaac aattaaaaaa gtatagatta tttttagatg
     8341 aaaaagtcag caaagaaaag atgcctaaaa atataaatga gatgattgtt ttttatttac
     8401 taaaattgaa aattccagtg ttgatttatt ctttttattc gtttaaagag tggtggaaga
     8461 gaagaaaaat taaaaatgaa ggataaataa gttatggaag atttgataag cattgttgtt
     8521 ccagtctata acgtggaaaa atatttaaaa aaatcaatag aaagtgtttt gaatcagact
     8581 tatcaaaata tcgagatttt attggttgat gacggaagca cagatagtag tgggaaaatt
     8641 tgtgaatcat ttagcaaagt tgatcctagg ataagagtat ttcataaaga aaatggtggt
     8701 ttatcagatg ctcggaattt tggaattgag caaatgaaag gtcaatatgt agcgtttatt
     8761 gatagcgatg actacatatc taaggattat gtctggaagt tgtattcttc tataaaaaat
     8821 aatgattccg aggtgtcgat ttgttctttt ttattagtcg atgaaaaagg ggaaaaaata
     8881 aaagatgagc tattagattc gggaaaaata tgcttgactg gtcaacaaat attagaaaaa
     8941 gtattaacag ccgacggcta tcgctatgtt gttgcttgga ataagcttta tcggtcaact
     9001 ttatttgaaa aattaaaatt taaaaaagga atgttgtatg aggatgaatt tcttaactat
     9061 cctctatttt gggactgtaa aagggtatca attgtagagg agccgttata tttatacgtt
     9121 caacgaaaag gaagcattgt acaaagtaat atgactttag aaaaaataaa gatgaaggat
     9181 gagatgcata cttcacgcat tgagttttat tcagaaaagg ggcattcttt tttgcacgaa
     9241 aaagcgtgtc aacagtactg caattggatt gttacagcga ctaccaatca tagtaagatt
     9301 ttaaatccta atttttcgaa gtatttacaa cgacagttta gaaagttcgc taaatataca
     9361 cgaaacaatg atattagact aattgtgcag aacattctag gatttataga tattcgttta
     9421 gcagcttatg taaaatcaaa agtaatgtag agtataggaa acataatgat agaaaaaatt
     9481 ttagattcta ttaaaaatca ttctttttat agtaaattga aggataaaat tcatagaatt
     9541 attccattat atattataaa aaatcaaaat atagcttttc aacaagatac cgatatagca
     9601 tatagaaaac taaagaagaa gtttaggcat atttcgttga ctggagatga gcttaaatat
     9661 aaaatggagt tttcaaataa agtttggatt tgttggtttc agggagaaga gcatgcccca
     9721 gagttaatta aaacatgtat tcaatcaatg aggaatcaac ttcaaggaag agaaatcatt
     9781 gtgttgacag aaaaaaatat aagtgattat acagagattc caggctatat tattgaaaaa
     9841 tacaaaaaag gatggatttc tcgtgcgcat tactctgata tccttaggat agatcttcta
     9901 tgtcgccatg gaggattatg ggtagatgca acagtgttga atacaggagg agatttctca
     9961 aatcttgagg taccactttt tgtatataaa tctttgaatt tatcaagaaa agattcacaa
    10021 gctattgtag catcaagttg gttaatttcg tcatatagta atcatcctat attactctat
    10081 acgagaaaac tcctatgggc ctactggcga agaaaaaata gtttatgtaa ttattttttg
    10141 ttccatatat gttttacaat agctacagag cggtacccaa tcgaatggtc tgctgtccct
    10201 acttttaata atcattctcc tcatatactt cattttgagt tgaatgaaca attttcggaa
    10261 aaacggtggg aacaactgaa gcatatttcg gcgtttcata aattaaatca tcatatagat
    10321 tattctagcg gtgttaacac tttttataag ttcatagtat cttcgaaagt ttagaaaaat
    10381 gagtaataaa attagtaaaa atttagccta caatatgggg tatcagttaa ttgggattgc
    10441 agctcccttg ataacttctc cttatttatc acggatatta ggtgctgaaa atttaggtat
    10501 tcattctttt actatgtcgg ttgcacttta ctttatgatg tttatgcttc ttggaattgc
    10561 aaattacgga aatagaacaa ttgcgactgt taaacgagaa ggaaaggata ttctatcaaa
    10621 aacgttttgg agtatctact ctatccagtt gataatgtct attctggtaa ctatagctta
    10681 tcttgcttat ctatatttgg gggcagtaca ttacaaagtt attgcaatat tacaactctt
    10741 tttattgtta tcaaatgctg ttgatattac ttggtttttc tatggattag aaaattttaa
    10801 gcaaatcgtt tttaggaata cattagtcaa acttttagga ttatttttaa tttttttatg
    10861 tgtgcgtcaa ggcacagatt tatggaaata cacatttata aacggatcag taactttagt
    10921 tggccaactt ttactatggg gacaattaaa aggaatatta acttggaaaa aaattcaatt
    10981 aaaggaatta ctacctcata tcaagccaat tttaattctt tttattcctg tactagccat
    11041 tagtattttt actaatatgg ataaatatat gcttggttta atggttgatg taaagcaggt
    11101 tggattttat gacaatgcag gtagaattat tgaaattcct aaagctttga ttgcagcttt
    11161 aggggccgtt atgttaccaa gaacttccta tttattagcg gaaggacaga aagaaaagag
    11221 taaatactac atagaggtaa caattttata cgtgatgatt atttctagtg tattgatgtt
    11281 tgggctaata tcggtatctg atattttttc cattatattt tggggagaag aatttcttga
    11341 atcaggtaga ttgatttctg ctatgtctcc ggcttttgtc ttctctgtat taggaaatat
    11401 cattaggact cagtatttga ttcctagagc taaggataaa gattatgtag tgtctctaat
    11461 tgcgggggct gttgttaatc tagtgctaaa ctattttttt ataaaacctt ttggtgctat
    11521 gggagcaaca gttagtacag ttttggcaga atttgtattg tctggaatgc agttttggtc
    11581 agtaagaaga gacttagatt taaaaagata tttgaaaaac ggtttgatat tctacctatt
    11641 tggtctgatt atgtaccttg ttattataac actcaaaact cagttaccat acaatataat
    11701 gagtcttatt ttactaatag ttttgggtgg aatagtatat gttatttttt gttgttgcta
    11761 tattttaatg tcaagaaatt tacattttaa gttattgaag gaaaagatta tacgaaaggt
    11821 tgtacataaa aatacattat aaaatattag ttttatttta tttagttgga tactattaaa
    11881 taaacgaaag tatttgaaac tttggtaatt gagattatag agataaacta agctatatta
    11941 tagcttcatt attaaagtaa gaatatcggt gcagtgtagt taacgaataa tgtgagtact
    12001 catttcttag atggagctag gggtcattat aagggattga tatgacattt tgagtaagtt
    12061 acagctagag tttaggtttg attatatcag atatttagat gatttggaaa ataataaaat
    12121 aagttaggaa ctattttttt attgttttga gtgacaggtt tgattttggg aaatgtattt
    12181 tgttaaatag gtaggaaaga tggttactaa agataaagga ttaacatata atagtacttt
    12241 gcatgcaata aaagtattag catgttttag tgttgttgct attcatatat ggctaccagg
    12301 aaaaattgga gcgttttatc aaataatagc acgatttgca gttccaatgt tctttttgat
    12361 ttctggcttt tattcatata atatttcaaa gaatagaatt aaaaaaatat ttagattgat
    12421 attaagaagt acatttttta tgtaataata tttgtatgga tgttttggag agaaggtaat
    12481 atgcagttta tttttccaat aaaagactac tattgacaaa acgatggatt tctatgcttt
    12541 tactattttc tttcattatg gaagctacaa ttagcgattc aattttttat agaaattttt
    12601 tatttatggg aataccattt tttggaatag gaattcttat tgcacagaat caaaagaaga
    12661 ttattaattg taaaataata aacaaaatat taatcttggg aacaattatc tatccaatac
    12721 taatattttt agaatattat atcttgggta attcttttga ggtctatata agttctgtgc
    12781 tagcaaccat aatattgatg attttcgcga ttaaatcacc taaagcgatt aatatcaaaa
    12841 tactgaatgg aattggagat aaatatgcga cttttgttta cattatacac cagtttatca
    12901 ttgtgatatt taaattttta gtatctaatg tttatattct caaatttggg acgatatttg
    12961 tctttttgat atgttgtttt ctaggggttc tatttcaatt tatcaaaaac agactattaa
    13021 aaaggtttag ttaagatggt tgttttacaa aatgttaaat ttttagtaag agttgttttt
    13081 atggttatta tcagtatagt gttatggcct gttcggataa agaagaataa gatactattt
    13141 attaatttta atggtaaggg atatggtgat aatccgaaaa gtatttgtga gtatcttcga
    13201 gttacatatc cagagttaga tttagtttgg cttgcaaaag ataatgaaga ttttccagat
    13261 ggagtgagag ttgtaagata taaatctcta caatcttttt atgagcaagc tagttcgaag
    13321 gtttgggttt ataatgtaag aaattttgaa agactactaa aaaaacgcgg acagttttat
    13381 attcaaactt ggcacggtgc ttctagtttt aaactgatag aaaagcaggc tgatttacca
    13441 ttaaaatata ttttagaagc aaagtatgat gcaagagtca cagatataat gatttcagat
    13501 agcagaaaac aaactgaaga atttcaaaag tatttttggt attcaggaga aatttttgag
    13561 gtggggatgc cgagaaatga tgccttgttt cactataagg aagactacga caagttaaat
    13621 aatatcagaa aagaactaag cattgattca gatgattatg ttattttata tgcccctact
    13681 ttcagagatg atggggatgc atcttattta gatataaatt ttgaacggct tttgcaaagt
    13741 attgaacaag aaattaagaa gaaatgtaaa attttaatta gattacatcc taatgactct
    13801 cattttagta ataatatttc ttttaatcat gacataattg atgttacgct attctcagat
    13861 atgcaggaac ttatattatt ggcagatgtt ttactgacag attattcttc cgcgatattt
    13921 gattttatgc ttttaaacaa gccttatgtc agatatgtga atgatttaga aaaatatgct
    13981 gagcttaggg gactatcaga tacatattac gaattgccgg accctatcat taaaactgct
    14041 gaagaattgt atgacttact gcctaaaaaa atagaaaatt ttgattatga ttctataaaa
    14101 aaatatagaa atgaaatact gtgtccaatc tttaatggaa ccgctagtga aaatgtagga
    14161 aggagaataa ttcaagagtt gtgaagtaaa acattgggtt atttttaagg taacgagatt
    14221 tgaaaaataa tgatttaaag ataggaagtg gagctattca tcaaatctcc gctacacttt
    14281 ctcaaaataa tatttcggga aagattttat attgtgctga tccagttgtc gatgacttgt
    14341 acggttcgat agtacgttca caaatagagg aaattggtcg ggtaaaggaa gaaagttgca
    14401 attataatac tattgcttat gcgatgaata tagcagaaag ggctattgcc acagatattg
    14461 actgtattgt gggaatggga ggaggtcgtg ttttagatgt ctgcaagtat gcatctttta
    14521 tttcgaaacg tccttaccta tcgattccga caacagcagc aaatgatggc attgcttccc
    14581 cagttgctgt tttgaaaagg caggatgata gaccaaaaag cttaggggcg gctatcccct
    14641 caatgacact aattgatatt gatgttattg catcaggacc tatacaaaac ataaaagctg
    14701 gtatcggtga tacaatatcc aattacactg cattgaaaga ttgggagttg gcagttgagc
    14761 gagggaaaga tgagatgcat ggttttgcat atctaatgtc gcaaaattct ttagatgctt
    14821 taatgaaaac gaagtataat tctattaccc ctgattttat tgaagttttg gtaaactctt
    14881 tagttttatc aggcattgca atggattttg cgggaagtag tagacctgtc agtgggtcag
    14941 agcacttatt tagtcatgca ttagattact atggttctac aaggaatctt catggaattc
    15001 aggttgcatt aggtacagtc gcagttttga aattaattga aaattctgtt gatgctgtgg
    15061 tggattactt gcaaagattt gaggttcata ttaacccgaa acttttgggg atagatgaag
    15121 agttgtttat ttattgtatg caacatgcta caaaaatgag aagtaatcgc tatacttatc
    15181 tgcatgaggt tgatcttagt acagatagat tgaaacaaat atataaggaa ctcataagcg
    15241 agttgtagaa aagagagaaa aaaatgaaag cacttatttt agcagcaggg ttaggaacac
    15301 gtctagcccc aattaccaat gaggtaccaa aatctttggt accagtcaat ggtaagccaa
    15361 ttttgatgaa acaaattgaa aatttatatc aaaataatat tacagatatt acgattattg
    15421 ctggatataa gtcatctgta ttaacagatg cagttactga aaagtatcca gaaattaata
    15481 ttattgataa tgttgatttt aaaacgacta ataatatgta ttcagcctat ctaggaaaag
    15541 ctgcaatggg tgatagtgac ttcttaatga tgaatgcaga tgtattttat gatgcttctg
    15601 ttattaaaag tctgttgctt cataaagctc caaatgcaat tgtaactgat ttaggtactt
    15661 atattgaaga gtctatgaaa gtcgtagaaa aaaatgggcg tttagtggaa atttctaaac
    15721 agatttcacc tgaggaggct ttaggggctt ctattgatgt ttataaattc tcttatgaag
    15781 caggtgctcg attctttgaa aagtgtaagg aatttattga agataaacga gaacttcaaa
    15841 tgtggagtga ggttgctctt aatgcaatcc ttccagaagt tgagtttata gcatgtccat
    15901 tggatggccg ttggttagaa attgataatc atgaagacct agctgttgca gaaaaactat
    15961 ttgcttaaac cgaatatgga gaatgaaatt gacaaataga gttgattatt ttggtgctga
    16021 tattagtgaa cttcagaata aaaaattatt cttatttgat atggatggta ccatttatga
    16081 agaagataga ttgtttgagg gtactctcga attattagac tatattcata atattggcgg
    16141 tgagtatatt tttattacaa acaattcatc taagtctgtt gttgactatg ttgaaaaagt
    16201 taacagatta ggtattaaag ctgaacgaga taattttttt acctctgctc aagccacaat
    16261 tgtttatatt aaagaaaatt atcctaaatc taaagtttat tgccaaggaa caaaatcttt
    16321 gataaaagaa ctatctgacg caggaattga tgtaactgag caagttagtg ctgatataga
    16381 tgttgttctt gttggttttg atacagaatt aaccagtgat aaaattcgca atacctgcga
    16441 gattctatca acaaaggacg tacctttcat agctactaac cctgatattc gctgcccagt
    16501 atcgtttgga ttcatcccag attgtggttc tatttgtgat atgattagta aatcagtcga
    16561 taggaaacct gtttacatag gtaaacctga acctacgatg gttgatattg ttcgaaaaaa
    16621 attaaattat tctctatttg aaacagttgt gattggagat cgcttgtata cggatatcat
    16681 gactggtata aatgcaggag taacttcagt ttgtgtgctg acaggagaag caacggtgaa
    16741 tgatattcaa caaggtagta taaaaccgac ttatacattt aaaaacgtga aagaaatgtg
    16801 gaaaggaatt gtctgatttt ttcattctga atagtgaatt catgaatact gtcaaaatac
    16861 tcgtatgtat ttaaattgat tttatta
//
LOCUS       DBERMM010000042        16697 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.044, whole genome shotgun sequence.
ACCESSION   DBERMM010000042 DBERMM010000000
VERSION     DBERMM010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 16697)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16697)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16697
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.044"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            70..567
                     /locus_tag="ACL8AS_001702"
                     /pseudo
     CDS             70..567
                     /locus_tag="ACL8AS_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234238.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="aldose 1-epimerase family protein"
     gene            724..1149
                     /gene="lacA"
                     /locus_tag="ACL8AS_001703"
     CDS             724..1149
                     /gene="lacA"
                     /locus_tag="ACL8AS_001703"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050044 - galactose-6-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HGS1229523.1"
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTL
                     AVAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMIT
                     MGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     gene            1180..1695
                     /gene="lacB"
                     /locus_tag="ACL8AS_001704"
     CDS             1180..1695
                     /gene="lacB"
                     /locus_tag="ACL8AS_001704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HGS1229524.1"
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPI
                     FGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNAN
                     VIGFGGKITGELLMCDIIEAFIHAEYKPTEENKKLIAKIEHVESHNAQQTDANFFTEF
                     LEKWDRGEYHD"
     gene            1706..2635
                     /locus_tag="ACL8AS_001705"
     CDS             1706..2635
                     /locus_tag="ACL8AS_001705"
                     /EC_number="2.7.1.144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="HGS1229525.1"
                     /translation="MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTR
                     VLSEFGDSVLATGLVGGKLGEFLVEHIDNQVKKDFFSIKGETRNCIAILHGDNQTEVL
                     EKGPEVLEQEGQEFLEHFKKLLESVEVVAISGSLPAGLPVDYYASLVELANQAGKPVV
                     LDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWI
                     IVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKA
                     NVLGMLNAQEKMTGHVNMANYQALYDQLIVKEV"
     gene            2637..3617
                     /gene="lacD"
                     /locus_tag="ACL8AS_001706"
     CDS             2637..3617
                     /gene="lacD"
                     /locus_tag="ACL8AS_001706"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HGS1229526.1"
                     /translation="MALTEQKRVRLEKLSDENGIISALAFDQRGALKRLMAQHQTEEP
                     TVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTK
                     RLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPF
                     FLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGF
                     AEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLC
                     GRATWAGSVEAYIKDGEAAAREWLRTTGFENIDELNKVLQRTATSWKERV"
     gene            3851..4687
                     /locus_tag="ACL8AS_001707"
     CDS             3851..4687
                     /locus_tag="ACL8AS_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HGS1229527.1"
                     /translation="MYRILNPMNHNVSLVRNDKGEEVIIIGKGIAFGKRKGDLIAENQ
                     VEKIFRMKTEESRENFMALLKDVPLDFITVTYEIIDKLSKKYHYPIQEYLYVTLTDHI
                     YCSYQALTQGRYKDSNLPDISAKYPVAFQIANEAFEIYRQKLADHFPEDEIIRIAYHF
                     INAEGENEVELVESIDKRKEILRNVEEVLKGYAIQRTKKNNHFYDRFMIHLNYFLDYL
                     DRSRDDNQSLLDMEDHIKQSYPKAFEIGSKIYDVITQHTGLDLYKSERVYLVLHIQRL
                     LS"
     gene            4723..5040
                     /locus_tag="ACL8AS_001708"
     CDS             4723..5040
                     /locus_tag="ACL8AS_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HGS1229528.1"
                     /translation="MNREEVTLLGFEIVAYAGDARSKLLEALKAAEAGDFEKADALVE
                     EAGSCIAEAHHAQTSLLTKEASGEDLAYSVTMMHGQDHLMTTILLKDLMHHLIELYKR
                     GVK"
     gene            5040..6731
                     /locus_tag="ACL8AS_001709"
     CDS             5040..6731
                     /locus_tag="ACL8AS_001709"
                     /EC_number="2.7.1.207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA];
                     GO_function: GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="HGS1229529.1"
                     /translation="MNKLIAFIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIF
                     ILIAFVPNSWGFKWSDEVVAFLMKPYSYSMGILALLVAGTTAKSLTDSVNRSMEKTNQ
                     INYMSTLLAAIVGLLMLAADPIENGLATGFLGTKGLLSAFLAAFVTVAIYKVCVKNNV
                     TIRMPDEVPPNISQVFKDVIPFTLSVVSLYALDLLARHFVGSSVAESIGKFFAPLFSA
                     ADGYLGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILT
                     SGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLV
                     LNPIFFIPFIFAPIANVWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQVLSFI
                     LAALLIVVDVVIYYPFLKVYDEQILEEERSGKSNDELKEKVAANFNTAKADAILEKAG
                     VDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPE
                     FDLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQAQFD"
     gene            6946..8352
                     /gene="lacG"
                     /locus_tag="ACL8AS_001710"
     CDS             6946..8352
                     /gene="lacG"
                     /locus_tag="ACL8AS_001710"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HGS1229530.1"
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWY
                     TAEPASDFYNRYPVDLKLAEEYGVNGIRISIAWSRIFPTGYGQVNAKGVEFYHNLFAE
                     CHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVDYAAFCFEEFPEVNYWTTFNE
                     IGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLYKEKGYKGEIGVVHAL
                     PTKYPLDPENPADVRAAELEDIIHNKFILDATYLGRYSAETMEGVNHILSVNGGSLDL
                     REEDFTTLEAAKDLNDFLGINYYMSDWMEAFDGETEIIHNGKGEKGSSKYQIKGVGRR
                     VAPDYVPRTDWDWIIYPQGLYDQIMRVKKDYPNYKKIYITENGLGYKDEFVDNTVYDD
                     GRIDYVKQHLEILSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERY
                     PKKSAHWYKKVAETQIID"
     gene            8475..8654
                     /locus_tag="ACL8AS_001711"
     CDS             8475..8654
                     /locus_tag="ACL8AS_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3884 family protein"
                     /protein_id="HGS1229531.1"
                     /translation="MTSEELKNLGKWYVSTGKEWICHSDDDLEEFKNLFLNFINPEEW
                     DTISFDSDFMPFQQS"
     gene            complement(8933..9694)
                     /locus_tag="ACL8AS_001712"
     CDS             complement(8933..9694)
                     /locus_tag="ACL8AS_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000917571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HGS1229532.1"
                     /translation="MLKQEKLTKILEIVNSKGTITVKQIMDEIAVSDMTARRYLQELA
                     DKDLLIRVHGGAEKLRTNSLLTNERSNIEKQALQTAEKQEIAHFAGSLVEERETIFIG
                     PGTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTL
                     QNLSNLQFSKAFVSCNGIQNGALATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDF
                     YTFYNISNLDTIVSDSKLSDSILFKLSKHIKVIKP"
     gene            complement(9876..10838)
                     /gene="nrdF"
                     /locus_tag="ACL8AS_001713"
     CDS             complement(9876..10838)
                     /gene="nrdF"
                     /locus_tag="ACL8AS_001713"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA];
                     GO_function: GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA];
                     GO_process: GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HGS1229533.1"
                     /translation="METYYKAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDW
                     RKLSNKEKDLVGKVFGGLTLLDTMQSETGVQALRADIRTPHEEAVFNNIQFMESVHAK
                     SYSSIFSTLNTKAEIEEIFEWTNTNPYLQKKAEIVNEIYLNGSPLEKKVASVFLETFL
                     FYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEEEQEKLK
                     EWMYDLLYTLYENEEGYTESLYDGVGWTEEVKTFLRYNANKALMNMGQDPLFPDSAED
                     VNPIVMNGISTGTSNHDFFSQVGNGYLLGEVEAMQDDDYNYGLD"
     gene            complement(11026..13185)
                     /gene="nrdE"
                     /locus_tag="ACL8AS_001714"
     CDS             complement(11026..13185)
                     /gene="nrdE"
                     /locus_tag="ACL8AS_001714"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000523276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HGS1229534.1"
                     /translation="MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVV
                     PNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLEELAQFIKDQNFQFKSFMAAYKF
                     YNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLN
                     AGRARRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGY
                     EGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVR
                     VKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYIDITEKYDELVANPNI
                     RKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPVDGKIIMSNLCSEILQVQEPS
                     LINDAQEFLQMGTDVSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPT
                     IDHGNSQAHTFGLGAMGLHSYLAQQLIEYGSPESVEFTSIYFMLMNYWTLVESNNIAR
                     ERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELFKNVFIPGVADWAELRDKVQ
                     EDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETI
                     PYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFMRSDIPKGLYEWKRENKQTTRDLS
                     ILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI"
     gene            complement(13266..13484)
                     /gene="nrdH"
                     /locus_tag="ACL8AS_001715"
     CDS             complement(13266..13484)
                     /gene="nrdH"
                     /locus_tag="ACL8AS_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin-like protein NrdH"
                     /protein_id="HGS1229535.1"
                     /translation="MVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKE
                     LGFSAAPVIQTPTEVFSGFQPGKLKQLA"
     gene            13835..14098
                     /locus_tag="ACL8AS_001716"
     CDS             13835..14098
                     /locus_tag="ACL8AS_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019775469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocarrier protein HPr"
                     /protein_id="HGS1229536.1"
                     /translation="MASKDFHVVAETGIHARPATLLVQTASKFASDITLEYKGKSVNL
                     KSIMGVMSLGVGQGADVTISAEGADADDAIAAISETMEKEGLA"
     gene            14104..15837
                     /gene="ptsP"
                     /locus_tag="ACL8AS_001717"
     CDS             14104..15837
                     /gene="ptsP"
                     /locus_tag="ACL8AS_001717"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008965 - phosphoenolpyruvate-protein
                     phosphotransferase activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HGS1229537.1"
                     /translation="MTEMLKGIAASDGVAVAKAYLLVQPDLSFETITVEDTNAEEARL
                     DAALQASQDELSVIREKAVGTLGEEAAQVFDAHLMVLADPEMISQIKETIRAKKVNAE
                     AGLKEVTDMFITIFEGMEDNPYMQERAADIRDVTKRVLANLLGKKLPNPASINEEVIV
                     IAHDLTPSDTAQLDKNFVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNNITEIVKDGD
                     ILAVNGITGEVIINPTDEQAAEFKAAGEAYAKQKAEWALLKDAQTVTADGKHFELAAN
                     IGTPKDVEGVNNNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVR
                     TMDIGGDKELPYFDMPHEMNPFLGFRALRISISETGDAMFRTQIRALLRASVHGQLRI
                     MFPMVALLKEFRAAKAVFNEEKANLLAEGVAVADNIQVGIMIEIPAAAMLADQFAKEV
                     DFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLINNVIKAAHSEGKWAGMCGE
                     MAGDQTAVPLLVGMGLDEFSMSATSVLRTRSLMKKLDTAKMEEYANRALTECSTMEEV
                     LELQKEYVNFD"
     gene            16090..>16697
                     /locus_tag="ACL8AS_001718"
     CDS             16090..>16697
                     /locus_tag="ACL8AS_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HGS1229538.1"
                     /translation="MKINKKYLVGSAAALILSVCSYELGLYQARTVKENNRVSYIDGK
                     QATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIFSEE
                     LLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHS
                     QHRESGTPRNDGAVAFARSQGRYTTDDGYIFNASDIIEDTGDA"
BASE COUNT         5193 a         3012 c         3467 g         5025 t
ORIGIN      
        1 ggattacgaa tgaatttgat tgctggcatt atcaatcatg aactaggatt ctagttttgc
       61 aggaagtcta ataaagaaac tagcaaggtc aggccttact ttattggtgg acatccagga
      121 tttaattgtc ctctatttga tgatgaagtc tatgaagatt attatctaga gtttgagaaa
      181 gaagagactt gctctgttcc acgtcctttc ccagaaacag gtatgttgga tttccaagat
      241 agaagtccat ggctagaggg acaaaaagaa atagatctta gttatgctct tttcagcaaa
      301 gatgcagtga ctttggatga attgcaatct cgaacaattg cccttcgttc tcttaaacat
      361 gataggggat tgaaagtgca ttttgcagaa tttccaaacc tcatcatctg gtcaactttg
      421 aacaagggac ctttcattac ctttgaacca tggtttggct tgtcaacatt ccttgaagaa
      481 ggagatcatt tagaagataa gaagaatgtt tgtctcttag aagccaatca ggttgaagaa
      541 ttagggtttg agatagaagt tttataaaaa agtaaaaaat aaataacaaa aacaaacaca
      601 aactgttgac ttcttcaaac aatagtagta tattatgttt gtgaggacta attgactgtt
      661 ttttaaagac agccaataca ctgctggaat ccagcataga aaaaataaaa aggagtatac
      721 aatatgtcta ttgttatcgg tgcagatgct gcaggtttga gattgaaaga agttgtgaaa
      781 gacttcttag aaaaagaaaa cttccacctt gtggatgtta cagctgaagg tcaagacttt
      841 gttgatgtga ctctcgctgt tgctgcagaa gtaaacaaag aagaacaaaa ccttggtatc
      901 gtgattgatg cttatggagc tggtccattt atggttgcaa ctaagatcaa aggaatggtt
      961 gctgcagaag tttctgatga acgttcagct tatatgactc gtggccacaa caactcacgt
     1021 atgatcacta tgggtgcaca acttgttggt gatgaattgg ctaaaaacat cgctaaagga
     1081 tttgttaatg gtaaatacga cggtggtcgt caccaaatcc gggttgacat gttgaacaaa
     1141 atgggctaat tagattatag taagaaaggt aagttaaaaa tgagaattgc aattggatgt
     1201 gaccacatcg taacagatga aaaaatggcg gtttcagaat ttttgaaatc aaaaggatat
     1261 gaagtcattg actttggtac ctatgaccat acacgtactc actacccaat ctttggtaaa
     1321 aaagtagggg aagctgtaac tagcggtcaa gctgatcttg gagtatgtat ctgtggtact
     1381 ggtgttggta tcaacaacgc tgtaaataaa gttccaggtg ttcgttctgc cttggttcgt
     1441 gatatgacaa cagcccttta tgctaaagaa caattgaacg ctaacgttat tggttttggt
     1501 ggtaaaatta ctggtgaatt gcttatgtgt gatatcatcg aagctttcat ccatgctgaa
     1561 tacaaaccaa ctgaagaaaa caaaaaattg attgcgaaaa ttgaacatgt tgaaagtcac
     1621 aatgctcaac aaacagacgc aaacttcttt acagaattcc ttgagaaatg ggatcgtgga
     1681 gaataccacg actaagaggt gacctatgat tttaacagtc acaatgaacc catccatcga
     1741 tatttcctat cccttggatg agttgaagat tgatactgtc aatcgtgtgg tggatgtaac
     1801 caaaacggct ggtggtaagg gactcaatgt tacccgagta ctttcagaat ttggcgattc
     1861 tgttcttgct actggtttag tgggtggcaa acttggtgag tttttggttg aacatatcga
     1921 taatcaagta aagaaagatt tcttctcaat taagggagaa actcgtaact gtatcgctat
     1981 tctccacgga gacaaccaaa cagaagttct tgaaaaaggt cctgaagtat tggaacagga
     2041 aggtcaagag tttttggaac atttcaaaaa actcttggag tcagttgaag tagtagccat
     2101 ctcaggtagt ctgccagctg gccttccagt tgattactat gcgagcttgg tagaacttgc
     2161 taatcaagct ggcaagcctg tagtcttgga ctgctcaggt gcagcacttc aggctgttct
     2221 tgaatcaccc cataaaccaa cagtcatcaa accaaataat gaagaattgt ctcagcttct
     2281 tggaagagaa gtttctgagg atttggatga attaaaagaa gtacttcaag aacctttgtt
     2341 tgcagggatt gaatggatta tcgtttcact tggtgccaac ggtacttttg ccaaacatgg
     2401 tgacactttc tacaaggtag atattcctag aattcaggtg gtaaatcctg ttggatctgg
     2461 agactctact gtggcaggaa tttcttcagg acttcttcac aaagaatcgg atgcagaatt
     2521 actcatcaag gcaaatgtcc ttggtatgct caatgctcaa gaaaaaatga ctggtcatgt
     2581 caacatggcc aactatcaag ctctatatga tcaattaata gtaaaagagg tataaaatgg
     2641 ctttaacaga acaaaaacgt gtacgcttag aaaaactttc tgatgaaaat ggtatcatct
     2701 cagctcttgc atttgaccaa cgtggtgctt tgaaacgcct catggctcaa caccaaacag
     2761 aagaaccaac tgtggcccaa atggaagaac ttaaagtctt ggtagcagat gaattgacta
     2821 aatatgcttc atctatgctt cttgaccctg agtatggact tccagcaact aaagctcttg
     2881 atgaaaaagc tggtcttctc cttgcttatg aaaaaacagg ttatgacaca acaagcacaa
     2941 aacgcttgcc agactgcttg gatgtttggt ctgcaaaacg tattaaagaa gaaggtgcag
     3001 atgcagttaa attcttgctt tactatgatg tagatagctc agacgaactc aatcaagaaa
     3061 aacaagccta catcgaacgc atcggttctg agtgtgtggc tgaagatatc ccattcttcc
     3121 ttgaaatcct tgcttacgat gaaaaaattg cggatgcagg ttctgtagaa tacgctaaag
     3181 taaaaccaca caaagttatc ggcgctatga aagtcttttc agacccacgc tttaacattg
     3241 atgttttgaa agttgaagtt cctgttaaca ttaaatatgt tgaaggcttc gctgaaggtg
     3301 aagtagttta tacacgtgaa gaagcagcag ccttcttcaa agcgcaagat gaagcaacga
     3361 acttgccata catctacttg agtgctggtg tatcagctaa actcttccaa gatactcttg
     3421 tatttgctca tgaatcaggt gcaaacttta acggagttct ttgtggccgt gctacatggg
     3481 caggatcagt tgaagcttac atcaaagatg gtgaagcagc agctcgcgaa tggcttcgca
     3541 caactggatt tgaaaacatt gacgaactca ataaagttct tcaaagaaca gcaacttcat
     3601 ggaaagaacg cgtgtaagaa agtcctccta gtttaggaac atgaatctaa aaaaatttaa
     3661 aaaaagttgt atgtaaaggt ttacaaaaca accgacttgt gctatactta aatcacaagt
     3721 taatacaagg tgagtgttac taagtaatat taggcatgat cacaggtgaa ttagaaatca
     3781 gctgattttc tagttcattt gtggtcattt tttgtactca tataccttta agatataaaa
     3841 ggaggttgac atgtatcgaa ttctaaatcc aatgaatcac aatgtctcgc ttgtcagaaa
     3901 tgataaggga gaagaggtga ttataattgg taaggggatt gcattcggaa aaaggaaggg
     3961 ggatttgatt gctgaaaatc aggttgagaa aatctttcgg atgaagaccg aagagtccag
     4021 agaaaacttt atggctcttc tcaaagatgt tccgcttgat tttatcacag tgacctatga
     4081 aatcattgat aagctatcaa agaaatatca ttatccgatt caagagtatc tctatgtaac
     4141 cttgacagat catatttact gttcttatca agctctaact caaggaaggt acaaggatag
     4201 taatctgccg gatatttccg ctaagtatcc tgtcgctttt caaatcgcaa atgaagcttt
     4261 tgaaatttac cgtcagaagc tagcagatca ttttcctgag gacgagatta ttcggattgc
     4321 ttatcatttc atcaatgccg aaggtgaaaa tgaagtggaa cttgtggagt cgattgataa
     4381 gaggaaagaa attctcagga atgttgaaga agtgctaaag ggttatgcaa ttcaacgaac
     4441 caaaaaaaat aatcatttct atgatcgctt tatgattcat ttgaattatt tcttggatta
     4501 tttagacaga tctagagatg ataaccaatc acttctggat atggaagatc atattaaaca
     4561 atcctatcca aaagccttcg agattggttc caagatctat gatgtgatta cgcaacatac
     4621 gggtcttgat ttgtataaaa gtgaacgagt ttatctagtt ctacatatcc aacgtttatt
     4681 gtcataaaaa tttatttaaa actatataag gagaattcta tcatgaatag agaagaagta
     4741 acattgttag gttttgaaat cgtagcctat gctggcgatg ctcgttcaaa actattggaa
     4801 gccttgaagg ctgctgaagc tggtgatttt gaaaaagcgg acgctctggt agaggaagct
     4861 ggtagctgta ttgcagaggc tcaccacgcg caaacaagtc tattgactaa ggaagcttca
     4921 ggtgaggact tagcgtatag tgtgaccatg atgcatggcc aagaccactt gatgacaact
     4981 atcttgttaa aggatttgat gcaccatttg atcgaactct acaagagagg agttaaataa
     5041 tgaacaaact aattgcattt atcgagaaag gaaagccttt ctttgagaaa ctatctcgta
     5101 atatctatct tcgtgctatt cgtgatggtt tcattgcagg tatgcctgtt attctcttct
     5161 caagtatctt tatcttgatt gcctttgtac caaactcatg gggctttaaa tggtctgatg
     5221 aagttgtagc ctttctgatg aaaccttata gctattctat gggtattctg gctctcttgg
     5281 tagctggtac aacagctaag tcattgaccg actcagtaaa ccgtagcatg gagaaaacca
     5341 atcaaatcaa ctatatgtca acgctgttag cagcgattgt tggtttgttg atgttggcag
     5401 ctgatcctat cgaaaatggt ctagctactg gattcttggg gacaaaaggt ttgctttcag
     5461 ccttccttgc tgcctttgtt actgtagcca tctataaggt ttgtgttaag aacaacgtca
     5521 ctattcgtat gcctgacgaa gttccaccaa atatctcaca agtctttaaa gatgtgattc
     5581 cattcactct atctgttgtt tctctttatg ctcttgattt actagctcgt cattttgttg
     5641 gttctagtgt ggcagaatca atcggtaaat tcttcgcacc actcttctca gcagcagacg
     5701 gataccttgg tattaccatt atctttggtg cctttgcctt cttctggttt gttgggattc
     5761 atggtccatc tatcgttgaa ccagctatcg cagctattac ctatgccaat gccgaagtca
     5821 acttgaacct tctccaacaa ggtatgcacg ctgacaagat tcttacttct ggtacacaaa
     5881 tgtttatcgt taccatgggt ggtactggtg cgactcttgt tgttccattc atgttcatgt
     5941 ggttgacaaa atcgaaacgt aaccgtgcaa tcggtcgtgc ttcagtagtt ccaaccttct
     6001 ttggtgtaaa tgaaccaatc ttgtttggtg caccgcttgt attgaacccg attttcttca
     6061 ttccatttat ttttgctcct atcgcaaacg tttggatctt taaattcttc attgaaactc
     6121 ttggaatgaa ttcatttact gctaatctac catggacaac tccagctcca ctaggtctag
     6181 ttcttggaac taacttccaa gtgctatcat tcattcttgc tgcccttcta atcgtggttg
     6241 acgttgtcat ttactatcca ttccttaagg tctatgatga acaaattctt gaagaagaac
     6301 gttcaggtaa gtctaatgat gaattgaaag aaaaagttgc tgcaaacttc aacactgcaa
     6361 aagcggatgc tattcttgaa aaagcaggtg tcgatgcagc acaaaatacc atcactgaag
     6421 aaacaaatgt cctcgttctc tgtgctggtg gaggtacaag tggtctcctt gcaaatgctc
     6481 taaataaggc agcagcagaa tacaatgtcc ctgtgaaagc agcagcaggc ggctatggtg
     6541 ctcaccgtga aatgttacca gagtttgatc ttgttatcct tgcccctcaa gttgcttcaa
     6601 actttgaaga tatgaaagca gaaacagata agctcggtat taaactagcg aaaacagaag
     6661 gcgctcaata catcaaatta actcgtgatg gaaaaggtgc tcttgcattc gtacaagcgc
     6721 aattcgatta aggctaggga ctctgaaata gtctcctatc gttacggaaa tcgctatggc
     6781 gaatttccta atcgccttat taattcgtcg gtaaaaagat aacgttttta cctcctcatg
     6841 tcacaattca gtgacttggt acaagaagtg agatggagaa gcatggctca ctgactcctc
     6901 tcctctcact tttactttat ttaaatcaag aaataggtga aaaaaatgac aaaaacactt
     6961 ccaaaagact ttattttcgg tggcgcaaca gctgcttatc aagcagaagg tgctacacat
     7021 actgatggaa aaggaccagt tgcttgggat aaatatcttg aggataacta ctggtacact
     7081 gccgaaccag ctagtgattt ttacaatcga tatccagttg acctcaagct agcagaagag
     7141 tatggtgtca atggtattcg aatttctatt gcttggtcac gtattttccc gactggttac
     7201 ggccaagtaa atgctaaagg tgttgagttt tatcataatt tatttgcaga gtgtcacaaa
     7261 cgtcatgttg agccttttgt aactcttcat cactttgaca cgccagaagc tctccactca
     7321 aatggagact tcttaaaccg tgaaaatatc gaacattttg tagactacgc tgccttctgt
     7381 tttgaagaat ttccagaagt aaactattgg acaaccttta atgaaattgg accaatcggt
     7441 gatggtcaat atttggtggg gaaattccct ccaggtatcc agtacgacct tgccaaagtc
     7501 ttccaatcac accacaatat gatggtgtct catgcacgcg cggtaaaatt gtacaaagag
     7561 aaaggctata aaggggaaat tggtgttgtt cacgccctgc ctactaaata tcctctagat
     7621 cctgaaaatc cagcagatgt tcgtgcagct gagttggaag atattatcca caataaattc
     7681 atcttagacg caacttatct aggtcgctat tcagctgaaa ccatggaagg tgtcaaccat
     7741 atcttatcag tcaatggtgg tagtttggat cttcgtgaag aagattttac aacattagaa
     7801 gctgcaaaag acttgaatga tttcctagga atcaactact atatgagtga ctggatggaa
     7861 gcctttgatg gagaaactga aattatccat aatggtaaag gtgaaaaagg aagctctaag
     7921 tatcaaatca aaggtgttgg tcgtcgtgta gctcctgact atgtaccacg cacggattgg
     7981 gattggatta tctaccctca aggtttgtat gaccaaatca tgcgtgtgaa gaaagattat
     8041 cctaactaca agaagattta catcactgaa aatggtctcg gctataaaga tgagttcgtt
     8101 gataacactg tttacgatga tggtcgtatt gattacgtga aacaacactt ggagatcttg
     8161 tctgatgcga ttgcagatgg agctaatgta aaaggttact tcatttggtc attaatggat
     8221 gtcttctcat ggtcaaacgg ttatgagaaa cgttatggtc tcttctacgt agattttgaa
     8281 actcaagaac gttatcctaa gaaatcagct cactggtaca agaaagtagc ggaaactcag
     8341 attatagact agtagaatta gtcattagat atagaatttt agtgagtcaa aaagatgttc
     8401 aaagatttta tccaatctat ttatgaaaaa aagtttatat tataaatttc gaaaaatact
     8461 ctcaaatacc gtgtttgacg agtgaagaat tgaaaaatct tggaaaatgg tatgtctcga
     8521 ctggtaaaga atggatttgt cattcagatg atgatctgga agaatttaaa aatctatttt
     8581 taaattttat caatcctgaa gaatgggata ctatctcctt tgattcagat tttatgccgt
     8641 ttcaacaatc gtaaccaatt tctcaaaaaa gttaaatctt atatttagta ctctgtaaaa
     8701 ctcttatcta atcacgttgc ttatactcaa tgaaaatcaa agagcaactt taaactagga
     8761 agcgagtcgc agatttctca atgtatagct ttgaggaatt gggcaaaaag tctttgatat
     8821 agaaaaaagc atagtatcag gtgtttcaac acctgatact atgcttttta ttgtgggaag
     8881 atttactttt tttcttctga aattgagttg ttacccaggc tctttcagtt tattaaggct
     8941 tgatgacttt aatgtgttta gatagcttaa aaaggattga atcacttagt ttagaatctg
     9001 aaacaatagt atcaagattt gatatattat aaaaagtata aaaatcaaac ttattgaact
     9061 tactatgatc tgcgagtaaa tattttttat tagaattatt taaagcgatg cgttgagcct
     9121 ctccctcttc ctcgctaaaa gtagctagag ctccgttttg aataccatta cagctaacga
     9181 aagctttaga aaattggaga ttagagagat tttgtagggt caatgtgcca acaaaagcac
     9241 ctgtaatatc gcgataattt ccacctatca aaatcaaatc tgttaatttt cgttcgctta
     9301 aaatcagaaa aacaggtaga ctgttggtta cgacgcggat attgtcaata ggcaactcac
     9361 gcgcaaaaaa ctctaatgtt gttcctggtc caatgaaaat agtttctctt tcttctacta
     9421 gactgcctgc aaaatgggct atttcttgtt tttctgccgt ttggagggct tgtttttcaa
     9481 tatttgatcg ctcattagtc aaaagggagt tggttcgaag tttttcagct ccaccatgca
     9541 cacgaatcag caaatcttta tcagctaatt cctgtaaata gcgccttgca gtcatatctg
     9601 aaacggctat ttcgtccata atctgtttaa ctgttatggt tcctttacta tttactatct
     9661 ctaaaatttt ggttaatttt tcttgtttga gcatattatc acctcgtttc ctactactat
     9721 cttaccataa acaaactcat cattcaaata caaaaacaac aaaatgaaac aaaaacaaaa
     9781 atatcgaagt ttgttttcaa aactttcgat atttttgttg ggttataact ttgatgtttc
     9841 tagtttactt tttgatgatt gagagtgatg gagaattagt ctaaaccgta gttatagtca
     9901 tcgtcttgca tggcttcaac ttcgccaaga aggtaaccat ttccgacttg agagaagaag
     9961 tcatggttgg aagttcctgt tgaaataccg ttcataacga ttgggttgac atcttcagct
    10021 gaatctggga aaagtggatc ttgtcccatg ttcatgagag ctttattggc attgtagcga
    10081 aggaaggttt taacctcttc agtccaacca acaccgtcat aaagactctc tgtgtagcct
    10141 tcttcatttt cataaagagt atagagtagg tcgtacatcc attctttgag tttttcttgc
    10201 tcttcttcag gcaattcatt gaaaccaagt tggaatttgt aaccaatgta ggttccgtga
    10261 acagactcgt cacgaataat caatttaatg atttctgcaa cgttggctag tttgttgtta
    10321 ccgagatagt agaggggagt gaagaaacca gagtagaaga ggaaggtttc gaggaagacg
    10381 ctggcaactt tcttttcaag tgggctgccg tttaggtaga tttcgttgac aatctcagcc
    10441 ttcttttgta ggtaaggatt ggtattggtc cattcgaaaa tttcttcaat ctcagcctta
    10501 gtattcaagg tagaaaagat tgatgagtaa gatttagcgt ggacagattc cataaattgg
    10561 atgttattga aaacagcttc ctcatgtggt gtacggatgt ctgcgcgaag ggcttgaacc
    10621 ccagtttcag attgcatagt gtcaagaagg gttaaaccac caaaaacttt tccgaccaag
    10681 tctttctctt tgttagatag ctttctccag tcatccaagt cgtttgataa gggaatacgt
    10741 gtatcgagcc aaaattgctc cgtcagtttt tcccaagttg atttgtcgat gacatcttcg
    10801 atggcattcc agttaatggc tttgtagtaa gtttccattt aaaatctctt tctgtgttta
    10861 gtattgcgaa ctcacaatta tttctacttt accataattc tataggagta tcgcacaaaa
    10921 agtcggaagc ccgactttta aaatgttaca taaattatgt tatgacatag tagatttgat
    10981 tttatcagtg ctgcttaggg aaaaataatg tttctatgct agaaactaaa tcacacagct
    11041 ttcacattgg ttggcgccga cttctccacc gtcatctgta aaggtacgga cgtagtagat
    11101 agacttgatt cccttgttaa aggcatagtt acgaaggatg gacaaatcac gtgtcgtttg
    11161 tttattttcc ctcttccatt cgtaaaggcc ttttggaatg tcactgcgca tgaagagggt
    11221 gagtgaaagt ccttgatcca cgtgttcagt cgcagcagcg taaacatcga tgactttacg
    11281 catatccata tcgtaggcag aagtgtagta aggaatggtt tctgtagaca agccagcagc
    11341 agggtagtag attttaccaa ttttcttctc ttggcgttct tcgatacgtt gcgtaatcgg
    11401 gtggatagaa gcagaaacgt cgttgatata gctgatagaa ccatttggcg ctacagcaag
    11461 gcgattttgg tggtaaagac catcttcttg aaccttgtcg cgaagttcag cccaatcagc
    11521 aacaccaggg ataaaaacat ttttgaagag ttctttaaca cggtctgatg ttggaacaaa
    11581 ttcaccagtt acatacttgt caaagtaact tccgttagca tagtctgatt tttcaaagtt
    11641 gtggaaggta ataccacgtt cacgcgcaat attgtttgac tctaccaagg tccagtagtt
    11701 cataagcata aagtagatgc ttgtaaattc aacagactca ggtgaaccat attcaatgag
    11761 ttgttgggca aggtagctgt gcagtcccat ggcaccgaga ccaaaggtgt gggcttggct
    11821 atttccatgg tcaatcgttg gtacagctac gatatgtgaa ctatctgtaa cgaaagtaag
    11881 ggcacgaacc atagcacgga tagaacgacc aaaatcaggt gaagtcatca tgttaaccac
    11941 gttggttgaa cccagattac atgaaacatc tgttcccatt tgaaggaatt cttgagcatc
    12001 gttgatcaag cttggttctt gaacttgaag aatctcagaa cacaagttac tcatgataat
    12061 ctttccatca acaggatttg cacggttagc cgtatcgatg ttgactacat aaggatagcc
    12121 agactcttgt tgcaatttag agatttcagt ttccaaatcc cgcgccttga tttttgtctt
    12181 gcgaatattt ggatttgcga ccaattcatc gtatttttca gtaatgtcga tgtaattgaa
    12241 tggcacaccg tattcttttt ctacagagta agggctgaag aggtacattt cttcattttt
    12301 acgagccaat tcgtagaatt tatcaggtac tacaacacca agtgatagag tcttgacacg
    12361 tactttttca tcagcgtttt ctttcttagt tgaaaggaaa gcgatgatat ctgggtgaaa
    12421 gacgttgagg tagacaacac cagcaccttg acgttgcccc aattggttgg agtaagagaa
    12481 gctgtcttca aaaagcttca taacaggaac gacacctgaa gcagctcctt catagccttt
    12541 gataggtgca ccagcttcac gaaggttgct gagggtaatt cccacaccac caccaatacg
    12601 tgaaagttga agagctgagt tgatagaacg tccgatagag ttcatatcat ccgtcacttg
    12661 gattaggaaa caagatacca actccccacg acgagcacgt ccagcattca agaaggaagg
    12721 agtagcaggt tggtagcgtt ggtggatgat ttcattggca atatcgattg caacagcttc
    12781 attcccatca gcgaaataaa gggcgttgaa gaagacacgg tcttccatat tttcaagata
    12841 gtattcaccg tcattagtct ttaaggcata ttgattgtaa aatttataag ctgccatgaa
    12901 tgacttgaat tggaagtttt ggtctttgat aaattgagcc aattcttcca agaactctgg
    12961 acggtatttc ttgataaagg ctgtttcgat gtagttgtgt tcaatgaggt aattgatttt
    13021 gtctttgatt gaatcaaaaa ccatagtgtt tggaactaca ttttctttaa agaaagcatc
    13081 caaggcttcc ttatctttat gaagcatgat ttgtccatta acaggacggt taatttcgtt
    13141 attaagacgg aagtaagtca cgtcttcaag atgttttaat cccataaaat ttcccttatc
    13201 taattacaaa agaaaggctt ctaagttagc cctaaaagca gtttcttctg gatgatgtac
    13261 taagattatg ctaattgttt cagttttcct ggttggaaac ctgaaaagac ttcagttggt
    13321 gtttggataa caggagctgc gctaaaaccg agctctttaa cttgatcgac gtactcaggt
    13381 tgctcatcaa gattgatttc acgataagag acattattac tgtccaagaa acgcttggtc
    13441 attttacatt ggacacaatt gtttttagaa taaacggtta ccattgtgta actcctcttc
    13501 aaaatttaat actatcttag tatatcagaa aataaaattt tgtcaatgat ttgaactaaa
    13561 tatagtggtg ttcttttgtt gtttttatat ataaacacaa tatatagtgt ttgtattgtg
    13621 aaatagcaat gattatccta taaattgttt ttaaagaaac tatatcctgt gttttgttat
    13681 ctaggataga agattttcag caagttatct gaaaggaaat tgaaggaaaa tccagaaaat
    13741 gcttgaaaaa aatcctagaa gatggtataa tactaaattg taagggttat cacatataac
    13801 tcaaaaaaag aaagaacaaa aggagagtca aactatggct tctaaagatt tccacgtagt
    13861 ggcagaaaca ggtattcacg cacgtccagc aacattgttg gtacaaactg ctagcaaatt
    13921 tgcttcagat atcactcttg agtacaaagg taaatcagtt aaccttaaat caattatggg
    13981 tgttatgagt cttggtgttg gtcaaggtgc tgacgtaact atctcagctg aaggtgcaga
    14041 tgcagatgac gctatcgctg caatctcaga aacaatggaa aaagaaggat tggcataagg
    14101 gaaatgacag aaatgcttaa aggaatcgca gcatctgacg gtgttgcagt tgcaaaagca
    14161 tatctactcg ttcagccgga tttgtcattt gagactatta cagtcgaaga tacaaacgca
    14221 gaagaagctc gccttgatgc cgctctacag gcatcacaag acgagctttc tgttattcgc
    14281 gagaaagcag taggtacgct cggtgaagaa gcagctcaag tttttgatgc tcacttaatg
    14341 gttcttgctg acccagaaat gatcagccaa atcaaggaaa ctatccgtgc gaagaaagtg
    14401 aatgcagaag caggtctgaa agaagttaca gatatgttta tcactatctt tgaaggcatg
    14461 gaagacaacc catacatgca agaacgcgca gcggatatcc gcgacgtgac aaaacgtgta
    14521 ttggcaaacc ttcttggtaa aaaattacca aacccagctt ctatcaatga agaagtgatt
    14581 gtgattgcac atgacttgac accatctgat acagctcaat tggacaaaaa ctttgtaaaa
    14641 gcttttgtaa ccaacatcgg tggacgtaca agccactcag ctatcatggc acgtacactt
    14701 gaaattgcag ctgtattagg tacaaacaac atcactgaaa tcgttaaaga cggtgacatc
    14761 cttgctgtta acgggatcac tggtgaggtt attatcaacc caactgatga acaagcggca
    14821 gaatttaaag cagctggtga agcttatgcg aaacaaaaag ctgaatgggc gctcttgaaa
    14881 gatgctcaaa cagtgactgc tgacggtaaa cacttcgagt tggctgctaa tatcggtact
    14941 ccaaaagacg ttgaaggtgt taacaacaac ggtgcagaag ctgttggact ttaccgtaca
    15001 gagttcttgt acatggattc tcaagacttc ccaactgaag atgagcagta tgaagcatac
    15061 aaggctgttc ttgaaggaat gaacggtaaa cctgttgtcg ttcgtacaat ggatatcggt
    15121 ggagataagg aacttcctta cttcgatatg cctcacgaaa tgaacccatt ccttggattc
    15181 cgtgctcttc gtatctctat ctctgagact ggagacgcta tgttccgcac acaaatccgt
    15241 gctcttcttc gtgcgtctgt tcacggtcaa ttgcgtatca tgttcccaat ggttgcgctc
    15301 ttgaaagaat tccgtgcagc gaaagcagtc tttaatgaag aaaaagcaaa ccttcttgct
    15361 gaaggtgttg cagttgcgga taacatccaa gttggtatca tgatcgagat tcctgcagcg
    15421 gctatgcttg cagaccaatt tgctaaagaa gttgacttct tctcaattgg tacaaacgac
    15481 ttgatccaat atacaatggc agcagaccgt atgaacgaac aagtttcata cctttaccaa
    15541 ccatacaacc catcaatcct tcgcttgatt aacaacgtta ttaaggcagc tcactctgaa
    15601 ggtaaatggg ctggtatgtg tggtgagatg gctggtgacc aaacagctgt tccacttctt
    15661 gtcggaatgg gcttggatga gttctctatg tcagcaacat ctgtccttcg tacacgtagc
    15721 ttgatgaaga aattagatac tgctaagatg gaagagtacg ctaaccgtgc ccttacagag
    15781 tgttcaacaa tggaagaagt ccttgaactt caaaaagaat acgttaattt tgattaatcg
    15841 aaaagtccct gcaactcagt tacagggatt tttttgatat tttaaaaaga attttcaaga
    15901 aaatctttct tatagaaaga ttttcttgaa aaagtagtag tcagaacaaa aaatacttaa
    15961 atggttcata aaattcttga caagttggag atttaggagt aaactattaa ccagttaagt
    16021 aatagagagg agtttctgca atttaaaaat gaattgcaac tagaaatatc aaatagaaag
    16081 agagtttcga tgaaaattaa taagaaatac cttgttggtt ctgcggcagc tttgatttta
    16141 agtgtttgtt cttacgagtt gggactgtat caagctagaa cggttaagga aaataatcgt
    16201 gtttcctata tagatggaaa acaagcgacg caaaaaacgg agaatttgac tcctgatgag
    16261 gttagcaagc gtgaaggaat caatgctgag caaatcgtca tcaagataac agaccaaggc
    16321 tatgtcactt cacatggcga ccactatcat tattacaatg gtaaggttcc ttatgatgcg
    16381 attttcagtg aagaattact catgaaagat ccgaactata agctaaaaga tgaggatatt
    16441 gttaatgagg tcaagggtgg atatgttatc aaggtagatg gaaaatacta tgtttacctt
    16501 aaggatgctg cccacgcgga taacgtccgt acaaaagagg aaatcaatcg acaaaaacaa
    16561 gaacatagtc aacatcgtga aagtgggact ccaagaaacg atggtgcggt agcctttgca
    16621 cgttcacagg gacgctacac cacagatgat ggttatatct ttaatgcttc tgatatcatt
    16681 gaggacacgg gtgatgc
//
LOCUS       DBERMM010000043        15914 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.045, whole genome shotgun sequence.
ACCESSION   DBERMM010000043 DBERMM010000000
VERSION     DBERMM010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 15914)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15914)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15914
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.045"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            69..1652
                     /locus_tag="ACL8AS_001719"
     CDS             69..1652
                     /locus_tag="ACL8AS_001719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1229539.1"
                     /translation="MNQIMKQYKFLYFLIILLSLTSALLMTFFSLQLGRILDSITNSN
                     SGLLFHITICVSLILLWFFISCSYSYLKNQYVKKVIIDLKKGLLLHYLSREFNQIDNR
                     NHSDFLNNITKNSDLIQENLLIPRISLIANLGTLIMSVVAIIYIEWRLALVFLLLSSI
                     TIFLSQIPGKLMTKATNNYSLQNSHYLSKMTNFINGFEQIKLLNIQSWTQEKIQGISL
                     EFEESRKTYQFLKDLASTTGILLSFGSQLSCMVAGIFFVRNNLLTIGLLVASIQLLNG
                     VFAPLQSILYNKNLISSSKSIIDNIQENLYETNHGTFHKTSTIDCDNISTISISQLYY
                     EIENRILFDHFSYEFKKGKRYAIIGASGTGKTTLVKLILNYYPKNLYDGEIKINGKQN
                     IDIPSEELYKDIAFVQKNDFLIEGNILENIKLARNLHLTEKLRKSLGFNEDFLRKNLA
                     QSNKIISEGEKQRIDLARFLVKTYSVYIFDEPTSNLDPIKANEIMDYILSIKDAIVIV
                     ITHDQNPEILEEFDHVITL"
     gene            complement(1662..2525)
                     /locus_tag="ACL8AS_001720"
     CDS             complement(1662..2525)
                     /locus_tag="ACL8AS_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000600261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1229540.1"
                     /translation="MILGETYRKIREEKGISISSLAGAEISKSQISRFELGETEISVF
                     KLLYLLERIGVTLEEFLLICNHYQPSDFNTLIASVKQAAYNEDTQTLLDMVEKEMELF
                     RGTNSHYHKLNAIFIESIVSGMDKNHQLSRQDASYLTNYLFSVENWGYYETLILGNCC
                     RVLSPDLLFRYTKEALKKGKLYSPIPRNRQSLIQLLLNSLIIMIENDLYEESLFLKQA
                     TKNILADSTDFFEQTILLYLDGYLELKFYHNQKSLLKIKEALKIFELFNKTIYKNYKQ
                     YFEKHIIHLVD"
     gene            3683..4324
                     /locus_tag="ACL8AS_001721"
     CDS             3683..4324
                     /locus_tag="ACL8AS_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HGS1229541.1"
                     /translation="MLNKVKTKALISVGAVAATSFILMMGYTAGQHSTAKQSRKEIEL
                     AAAKLVEDKQAEDKASILLSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELSS
                     QNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTNQTE
                     TRTVKLSYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPSLPNTTTK"
     gene            4334..5419
                     /locus_tag="ACL8AS_001722"
     CDS             4334..5419
                     /locus_tag="ACL8AS_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590072.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toprim domain-containing protein"
                     /protein_id="HGS1229542.1"
                     /translation="MEIEECKKISILDVASRLGISFKQVSSSVYEHPEHDSFRIFSTT
                     NTFKWFSRDIQGDVIDFVRLVKGISFKEALAFLSEEPFQKETVQEKRERPFYYPLKRI
                     EDSHCSLARYYLTECRGISEEIVQKMIQQGLIVQASWKTNETVEPVIVFKSFNHRHKL
                     QAASLQGIYKNHSLPRERLKTILKGSHGHVGISFDIGKPNRLVFCESFIDLMSYYELH
                     QQSLTDVRLVSMEGLKRSVVAYQTLRLIAEENQRLEFLDTVIPSKLLPLINTIRDTTS
                     YFDNHPDLLTLAVDCDDAGKDFSDKLSQSGFPVFLDFPDNKSGKEKVDWNDVLREKKS
                     DLQLMIENAKETLRNQPVRKTSQCLEL"
     gene            5470..5703
                     /locus_tag="ACL8AS_001723"
     CDS             5470..5703
                     /locus_tag="ACL8AS_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5965 family protein"
                     /protein_id="HGS1229543.1"
                     /translation="MTIIERLEEKVTRQESKVARETEKLAAYKEQLETAMFATFKRRQ
                     SISHMSFEEALDHAFGKERQFDDSEFRKDEMSE"
     gene            5700..6083
                     /locus_tag="ACL8AS_001724"
     CDS             5700..6083
                     /locus_tag="ACL8AS_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5945 family protein"
                     /protein_id="HGS1229544.1"
                     /translation="MTKDWNFNQPLESKSENQEDPDKIAALFRNHQGGNDVNYEAAFQ
                     KRKQAPVTDSNSSSKPKVTEVRTGKETDITTSYQQHLKRLIADNNSDIQSSQKKIEEL
                     HTFIDTKNKDNKKLQSIYDAISDLH"
     gene            6121..6396
                     /locus_tag="ACL8AS_001725"
     CDS             6121..6396
                     /locus_tag="ACL8AS_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229545.1"
                     /translation="MFTTFFKKNHDNSDVFKKLIHRLSDMSVQDLEKIDRLLDIIFTP
                     DQESEQVKTESIYREETLDDTLKEAKNQLHKEQLEKNLERFRKDGRK"
     gene            6478..7110
                     /locus_tag="ACL8AS_001726"
     CDS             6478..7110
                     /locus_tag="ACL8AS_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3990 domain-containing protein"
                     /protein_id="HGS1229546.1"
                     /translation="MELTTKQEKQLGQTQWFHATLLRHLESLKSGIDVKFNLGSELDF
                     GPGFYITPDFEQARKFINKQVEVLNRSSSNNNIFDSEEEVGIIVEFRISNFIEIFKNP
                     DYHCHYFAKHKKSESDLDFAEFVVQNRENPDELQHHFDFIYGVQTDDNPTQALARFRQ
                     NEITKEEMLAEFRKPYSFKQLSIHNQSFCDIMKIEKVYQSKTGEELQKWQ"
     gene            7101..7328
                     /locus_tag="ACL8AS_001727"
     CDS             7101..7328
                     /locus_tag="ACL8AS_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000301903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229547.1"
                     /translation="MAVVSLENNIKLYSSELFQALLKASNYKLDKRIAQTVAEGYARN
                     LDYSDPELMHVGVTSVANNLLTKIKQEYFNV"
     gene            complement(7487..7663)
                     /locus_tag="ACL8AS_001728"
                     /pseudo
     CDS             complement(7487..7663)
                     /locus_tag="ACL8AS_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000433508.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            7697..8068
                     /locus_tag="ACL8AS_001729"
     CDS             7697..8068
                     /locus_tag="ACL8AS_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000540234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="HGS1229548.1"
                     /translation="MGYEVQLALIATKPKLSYLSTLIRYEKLYAINPDQARATPKEHH
                     DFIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSEEDKTSVATVLHDLLFGEWNQV
                     EKEMLKSGEGKLKDLTNRNGC"
     gene            complement(8446..9342)
                     /locus_tag="ACL8AS_001730"
     CDS             complement(8446..9342)
                     /locus_tag="ACL8AS_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HGS1229549.1"
                     /translation="MDYKLISTYLDYCKTHKRLSSHTIRAYKNDLMQFYNSNYDNVES
                     YIEELTQSNIKTNTLRRKIACIKVFYNYLKYQHIIEENPFNQLRFQFRTEKILPKTIP
                     YDILKNIFSYLEQRVVISKTDYQKQKAERNLLIISLLLSTGIRISELCHIHLKDINLS
                     NKTLHIIGKGKKERILFLGDQTTFNLLETYINKNGKESNDFLFPGKHSPKPLSEQSVR
                     LILKRIVEQNGLSKTITPHMFRHSFATMLLDNDVDIRYIQQILGHSSISITQIYTHVS
                     HSKQKEILSSFNPMSVIHSEIE"
     gene            9436..10008
                     /locus_tag="ACL8AS_001731"
     CDS             9436..10008
                     /locus_tag="ACL8AS_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000066279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229550.1"
                     /translation="MTNKKIRVFLSRPNPFTENQNLFIKELIKFLRRHNIECVTLQAA
                     EYTPYEVMNSLSEMIQRSYGIIIVAFGQTFISSGTRKMGAEDNPDFFASKETHLKNKW
                     VTSVYCHIEGILALTYNLPMLSIPQESLTEEGILKKGEYSITSPEFSLETKENILMYL
                     QSEGFQKSFHVWKNLLDDKYNFIKGGEINY"
     gene            complement(10005..11255)
                     /locus_tag="ACL8AS_001732"
     CDS             complement(10005..11255)
                     /locus_tag="ACL8AS_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229551.1"
                     /translation="MTSCFVVMGFNTKKIPNTNIEVDLNQVYNNLIKPTILEKELVSV
                     HGKNHFRADEVFSTQSITKTFIEGILKADIVIADITTLNQNAIYELGLRHAMKPKSTI
                     ILCDHHTAKISFFDIAHLPQIRYDSDKLNEVDEVNKVKKLLSEYIDSAIKSDETFTDS
                     PAFESALYRVIINDLIDKTEIQSEEALDKSIAELYDQATELKNSEKYPEAEEIFQQIL
                     ESGYIDEEILAGYLLSSYKKNESSLANLKMAQQNISKYIDINTTTYHKLLGIYGAIFL
                     RIFYITKNRSDLMSAINYYRLGMNFEDRNIYCARNYCANLLKIALVEKDVEVLKEFYY
                     TSVYTAKTILGSLEKIHRKSSEYDDIWFLSNQEDLMLISGLLSKPINDIEGLTERQKK
                     TINEGSIMLSEDLQRIKTAIVNGN"
     gene            11906..13975
                     /locus_tag="ACL8AS_001733"
     CDS             11906..13975
                     /locus_tag="ACL8AS_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HGS1229552.1"
                     /translation="MKLTKVIINNFRSFGESQIIELNNQTVLIGNNSSGKTTVLQALS
                     KLFSDKQNDRIIKKSDFHLPKGSRPGENTRNLFIETIFEFDELDGTPYSQAIPSFFEH
                     FTVSKDGAKPFLRIRLESSWEDDGTVEGSIDTQFYYISSDEDTIRDEDKHRAPRKDLD
                     KIRVLYVPASRTPEKELGNASGSMLSRLVNSINWTEDEINEITDKIDELNNTFLSENG
                     ALTQINNEIQKSWELYHEDNRFSQAELIINSSEMAAALRQIALKFSPTTTEEAFTVSD
                     LGDGLRSIFYFSLVDSILDIELEITKDREENPDNPRFKLIPPVLTILAIEEPENHIAP
                     HHIGKLIKRFKQLGNNDNSQVILTSHSPAIVKRIDPEDLKYLRIENNDRVLQTIVSDI
                     QLPPAIDESYKYIKGAIQAYPELYFAKLVVLGEGDSEELLLPKFFDLLGKEVDSSQIS
                     IVPLGGRHVNYFWKLLNALRIPHITLLDFDNERYGGGWGRIKYISQHLYELNTEFQEW
                     FHTQRLDFNEIGSRGCESIGAQRLINWFNKLEEFNVYFSSPLDIDFLMLQHYKDNYLN
                     TLSPIEGPVVSYNDSDGSSKKVKLSDLDCLDRLQLEGFNKRKEEAIRATLKDKSGHGD
                     SFNEEEKELMIWYQYFFLGRGKPTTHMQFLSSISDDELTRNLPPVFEKIVNSAEELLG
                     DIQHGKE"
     gene            13962..15779
                     /locus_tag="ACL8AS_001734"
     CDS             13962..15779
                     /locus_tag="ACL8AS_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HGS1229553.1"
                     /translation="MVKSEEWFPKGDIILEETALGAVKDVTNCLVIAGPGAGKTELLA
                     QKLDYLFSTNKCVSPKKILALSFKTDAASNLKERVKKRYGDEYASRFTSLTYSAFEKR
                     ILDQFRDVLPEDIRPSRDYLIEDWYTIKELLSMNGINVNGWRMSDIRRYVENIILNNG
                     DNHKFKTDLLKGTQDNKPVLLYRQITKLSTQIIDTNEYIRKALQMTYDFVFLDEFQDT
                     TYAQYDLLKTCFLGSSCKLTAVGDDKQAIMRWAGAKPDIFPDYIRDFNPNEYQLLMNH
                     RSVPKLVEFQKEVHQILNSNHSSIQTNNYPEFQEGEITLFEFENESLEAKLIANDIES
                     KIQGGIRPSEICILAKQKVGIYSFELISILNSKGIKARIENEYQDILKDPTCNLLLDL
                     ISCSQGKRDPLIWENISNFYGNINGIDELTDELILAKSYKEIDNIVSDITYLISNFIP
                     NEESMLKLIDCIIEKIDEKRIISNFSTYNGKSDLDIIVKNFSKLLYIEYSQTQGEWLD
                     TVSSFKGENSIPIMTIHKSKGLEYEVVYFLGLEDSAFWSFNNQPEEDKSAFFVALSRA
                     KSHLIFTYCKLRNNSPQNNRNINEIYSLLTQSNLVDVIN"
BASE COUNT         5660 a         2266 c         2685 g         5303 t
ORIGIN      
        1 ggaagtttgt ttctgatttt catatttgga ttataatatt ctcatcagag ttacttaagg
       61 agtaagatat gaaccagatt atgaaacaat ataaatttct atatttcttg attattttat
      121 taagcttgac aagtgctctt ttaatgacat tcttctctct tcaattagga agaatacttg
      181 atagtataac taattcaaat agtggattac tctttcatat cactatttgt gtaagtttaa
      241 ttttactgtg gttctttatc tcttgttctt attcctatct taaaaatcaa tatgtaaaaa
      301 aagttattat agatctaaaa aagggtctct tattacatta tttatcgcgt gaatttaacc
      361 aaattgacaa ccgtaaccat tcagatttct taaataatat caccaaaaat agtgacctta
      421 ttcaagaaaa tttattgatt cctagaatct ctctaattgc aaatttaggg acccttatca
      481 tgagtgtggt tgccattatc tatatagaat ggcgattagc attagtcttt cttttattgt
      541 cgagtataac gatttttcta tctcaaattc ctggaaagtt aatgactaaa gcaactaata
      601 attattccct acaaaatagt cactatttgt caaaaatgac aaactttatt aatggttttg
      661 aacaaattaa gttattaaat attcaaagct ggacccaaga aaaaattcag ggaatcagtt
      721 tagaatttga agagtccaga aagacatatc aattcttaaa agacttagct tcaactactg
      781 gaattttact aagttttggc tctcaactat cctgtatggt cgctggtatc ttttttgtaa
      841 gaaataactt actgactatt ggactactag tagcaagtat tcaattatta aacggtgttt
      901 ttgctccact acaatctatt ctttacaata aaaatttaat cagcagtagc aagtccatta
      961 ttgataatat ccaagaaaat ctatatgaga caaatcatgg aactttccat aaaacaagta
     1021 caattgattg tgataacatt tcgactattt ctattagcca attatattat gaaattgaaa
     1081 atagaatatt atttgatcat ttttcctatg aatttaaaaa aggcaagcgc tatgcgatta
     1141 tcggtgcttc aggaactggg aaaacaactt tagtaaaatt aatactaaat tattatccaa
     1201 aaaatcttta tgatggagaa ataaaaatca acggaaaaca gaatattgat attccctcag
     1261 aggagttata taaagatatt gcgtttgtgc aaaaaaatga ctttctaatt gaaggcaata
     1321 ttctagagaa tatcaaattg gctagaaacc ttcatttaac tgaaaaatta agaaaatcct
     1381 taggttttaa tgaagacttc cttcgtaaaa acctagctca atcaaacaaa atcatttcag
     1441 aaggagaaaa gcaacgaatt gatttagcta ggtttttagt caaaacatat tcagtttata
     1501 tatttgacga acctacaagt aaccttgatc caataaaagc aaatgaaata atggactaca
     1561 ttctatccat taaagatgca attgttattg tcattactca tgatcaaaat ccagaaatat
     1621 tggaagagtt tgatcacgtt attaccttat agataaatgg cctagtctac taaatgaatg
     1681 atgtgtttct caaagtattg tttgtaattt ttgtagattg ttttattgaa gagttcgaaa
     1741 atttttaaag cttctttgat ttttaaaagt gatttttgat tatgatagaa tttcagttcc
     1801 aaatatccat ctaaatatag caaaatagtt tgttcaaaaa aatctgtgga atccgctaat
     1861 atattcttcg tagcctgttt taaaaataaa gattcctcat ataagtcgtt ctcaatcatt
     1921 ataatcaaag aattgagaag tagttgaatg agagattgtc tatttctagg tataggacta
     1981 tacaacttcc cttttttgag cgcctctttg gtatatctaa ataataaatc tggagataga
     2041 acacgacagc aatttccaag gatgagcgtt tcgtaataac cccagttttc aacagaaaat
     2101 aaataatttg taagataaga ggcgtcctga cgactcaatt gatgattctt atccattccc
     2161 gaaacaatac tttcaatgaa aatagcattt aatttatggt aatgagaatt tgtcccacga
     2221 aaaagttcca tttctttctc taccatatct agtaatgttt gagtatcttc attatatgcg
     2281 gcctgtttaa cagaagctat taaggtatta aaatccgaag gttgataatg attacagata
     2341 agcagaaatt cttctagtgt tactcctatt ctttcaagaa gatacaataa cttaaagaca
     2401 gaaatctctg tttctcctaa ttcaaaccta gatatttgag attttgaaat ttcagcacct
     2461 gctaatgaag aaatagaaat ccccttttct tctcttattt tcctataagt ttcacctaaa
     2521 atcatactta tctccattta ccataaacaa tcattagaaa atgtgaccga ttatgaaaaa
     2581 atactatcaa atttttttat tactatttga tattatcatt attattggat tatatcaata
     2641 acattaatga gtgtgggaaa aaactcaatt tcaggagaaa aaatgaatat ttccacaata
     2701 aaacgtatga tatcaagttt tttggacagc ctctgttcgt aaattatttt aactcatagt
     2761 tgatgattcc acaaattgaa aagttttaaa cttagcattt aaacgctcaa ttttaatacg
     2821 tattataact atctctatta aatttcttat cctctacagt caattcatgc ctttttgaac
     2881 tttttatagg aataaagata tctgatgaat attcacagta tctaaataac aaaaacaagt
     2941 gattgctctg acaaacttga cctatacttt ctttaaaaag agtaaaatca tgtgtatgac
     3001 catctcaaaa aaaaaattga caggcacgaa gtgtcgttaa atcgagtatg attgtgtctt
     3061 tatggtgtat atctttttcc aggataattc ttactttggt ttctttagga cattgaaata
     3121 ggactttcta tgacatcaat agctatagtg acacttgctg cttttaagtt gtctaaggca
     3181 aatatacctg aagaacgaag agtatcttct accaatatta tcgttcggtg actgtcgcta
     3241 atccaagacc aaaatcaaaa gctaggagac gtagagttgt tcaatagaat aaataacgca
     3301 agtttagcat caactgtttt tatagactta gcgtttttga acgtcctcct ttatagtgtt
     3361 tggttttata agctttattt agacaggata tcttcgttgg gaaggtgtcc ttttttacac
     3421 taataaataa tttaaagttc tcagaagtta gttgcatgat cttttgtaaa tagttttctt
     3481 aactatagta tagcatagta cagtatgcat tttatttttt tccaataagt ctattatact
     3541 gtcaaagaca gctagttttt ttttctctga actgtacgat tttgtgcctg aaatgtagga
     3601 attacctttc gttgtgatgt gataaaactt acaagttctt tttgttattc ttgacctagt
     3661 ttttatagaa agaaggtcta agatgttaaa taaagtcaaa actaaagcct taattagtgt
     3721 tggagcagtg gctgcaacta gctttattct catgatggga tatactgctg gtcaacattc
     3781 tactgctaaa caaagtcgta aagagattga attggctgca gctaaacttg tagaggacaa
     3841 acaagcagaa gataaagcaa gtattttgtt atcagatact gtaaaagaat ttttgacaca
     3901 gtactatacg aaagaaaagc tcggagaaaa taatacacgt attcaacctt atatgactga
     3961 atcggcttat tctcaagaat tgtcaagtca aaatgatgcc atgaaccaag tgtataagga
     4021 ttatatttta gattatcatt tcgaaaaagc tgatatcttt gtcaatcaga ctacgaatca
     4081 agctattgcc atggtctctt ataatgtaac ctatgtatct gatttaaaga atgccaacca
     4141 atcaaagacg aatcagacag aaacaagaac agttaagtta tcctattcta aactacctgg
     4201 taagttattg gtcaaccaag tacaggtttg gaaatctggg ttagatgatt tagataaggc
     4261 aactcctaaa actttagaag aatcctcatc tgttccatca ctgccaaata ctacgacaaa
     4321 atgatgatat tgcatggaaa tagaagaatg taagaaaatt tcaattcttg atgtagcaag
     4381 tcgtttaggt atctccttta aacaagtttc gagcagtgtc tatgaacatc ctgaacacga
     4441 ttcatttcgg attttttcaa ctaccaatac ttttaaatgg ttttcaagag atattcaagg
     4501 tgatgtcatt gattttgttc gacttgttaa gggaatttcc tttaaagaag ctctagcctt
     4561 tctttctgaa gaaccttttc aaaaagaaac tgttcaagaa aaaagagaga gaccatttta
     4621 ttatccttta aagagaatag aagattctca ctgtagtctg gccagatatt acttaacaga
     4681 atgtagagga atttcagaag aaatcgtaca aaagatgatt caacaaggtt tgatagtaca
     4741 agctagttgg aaaacaaatg aaacagttga acctgttatt gtttttaaaa gctttaatca
     4801 tcgtcacaag ctgcaggcag caagtctcca agggatttat aagaatcact ctcttcctag
     4861 agagaggtta aaaacgattc taaaaggaag ccatggacat gttggaatat cctttgatat
     4921 tggtaaacct aatagactgg tcttttgtga atcgttcatc gacttaatga gctattacga
     4981 acttcatcaa caaagtctaa ctgatgttcg tttggtatct atggaaggat taaaaaggtc
     5041 tgttgttgct tatcaaactt tacgactgat agctgaagaa aatcagaggt tggaattttt
     5101 ggatacagta ataccttcaa agttattgcc tttaatcaat acaattcgtg ataccaccag
     5161 ctattttgat aatcatcctg atttattgac acttgcggta gattgtgatg atgcaggaaa
     5221 agatttttct gataagttat ctcaatcagg atttcctgtt tttctggatt tccctgataa
     5281 taaatctggg aaagaaaaag tagactggaa tgatgtcctt agagaaaaga aatcagattt
     5341 acaattgatg atcgagaatg caaaagagac attgaggaat caaccagtaa gaaaaacctc
     5401 tcaatgttta gaattgtgat aacaaaatca agatgtttta gctaatatta gaatgaagga
     5461 ggatcgtata tgaccattat tgaacgctta gaagaaaagg tcactaggca agaaagtaag
     5521 gtagcaagag agacagaaaa actcgctgct tacaaagaac aactggagac agcgatgttt
     5581 gcgacgttca aaaggcgtca aagcattagt cacatgagtt ttgaagaagc tcttgaccat
     5641 gcctttggta aagaaagaca attcgatgat tctgaattta gaaaggatga aatgagtgaa
     5701 tgacaaaaga ttggaatttt aatcaaccat tagaaagtaa atcagaaaat caagaagatc
     5761 cagataaaat tgcggcctta tttagaaatc atcaaggagg taatgatgta aattatgaag
     5821 cagcttttca aaagcgaaaa caagcacctg tgacggattc aaattctagt tctaaaccca
     5881 aagttacaga ggttagaaca ggaaaagaga cagatatcac tacaagttat cagcaacatc
     5941 ttaaaagact tattgcggat aacaatagcg atattcaaag cagtcaaaag aaaattgaag
     6001 agctacatac atttattgac acaaagaata aagacaataa gaaattacag tccatttatg
     6061 atgcgatttc ggatttacac taagcagtcc tgataggctg ctttttttga gaggttatag
     6121 atgtttacaa cattttttaa gaaaaatcac gacaatagtg atgtatttaa aaagctgatt
     6181 catagactat ctgatatgtc tgtccaagat cttgaaaaaa tagaccgact gttagatatc
     6241 attttcactc cagatcaaga atcagaacaa gtaaaaacag aatcaattta tagggaagaa
     6301 actttggacg acacattaaa ggaagctaag aatcaacttc ataaggaaca attggagaag
     6361 aatttagaga gatttaggaa agacggaagg aagtgaatag ttttatacaa ttttctttta
     6421 cttgaataaa gtcttgtgtt atacttttag tatagactag agaaggaagt aaatattttg
     6481 gagttgacta ccaagcagga aaagcaacta ggtcagacgc agtggtttca tgctacatta
     6541 ttgagacatt tagaatcctt aaaaagtggt atagatgtta aatttaattt aggaagtgag
     6601 ctagattttg gtcctggttt ctatatcacg cctgactttg aacaagctag aaaatttatt
     6661 aacaagcaag ttgaagtatt aaatcgaagc agctctaata ataatatttt tgactcagaa
     6721 gaagaagtag gaattatagt agaatttcgt atttcaaatt ttatagaaat ttttaagaac
     6781 cctgactatc attgtcacta ttttgcaaaa cataaaaagt cagagtcaga tttagatttt
     6841 gctgaatttg tcgttcaaaa tcgggaaaat ccagatgaat tacaacacca ttttgatttt
     6901 atctatggtg ttcagactga tgacaatcca acccaagctt tagctcgttt tcgtcagaat
     6961 gaaattacaa aagaagaaat gcttgctgag tttagaaaac catattcttt taaacaatta
     7021 tccatccaca accaatcttt ttgtgatata atgaaaatag agaaggttta tcaatcaaaa
     7081 acaggagagg agttacaaaa atggcagtag tatcattgga aaataatatt aaactatata
     7141 gttcagaatt atttcaagca ctattaaaag cctctaatta taaattggat aagcgtattg
     7201 ctcagactgt tgcagaaggc tatgctcgta atctagatta ttctgatcct gaactgatgc
     7261 atgttggtgt aacttcggtt gctaacaatc tgcttacaaa aattaaacaa gagtatttta
     7321 atgtatagta ttttaaaaag ccaccgaaaa aggaattact ctttaaggtg gcttttttag
     7381 aagtaaagtt taggctagaa aaacaagaag taacgcacca aaaatggtgc atttcttttt
     7441 tctaaatgtt acggctcttt gtcaactgca gtgggttgaa gaaaagctaa gatcttgaaa
     7501 ggacacattt cgtcctttct tttttgatgt tcagagcgat aaaaatccgt tttttgaagt
     7561 tttcaaagtt tcgaaaacca aaggcatttc gtttgatgag tttaatgaga ttattagtcg
     7621 cttccaattt ggcgttagaa tagggtagtt aaagggcgtt gatgttccaa aggaaacagc
     7681 acaactcttg aaaagtatgg gatatgaagt acaattagct ttgattgcga caaagcctaa
     7741 gctgtcctat ctgagcaccc ttatccgtta tgaaaaactg tatgctatca atccagatca
     7801 agcacgcgca actccaaaag aacatcatga tttcattgta aatcatctag ttgataatac
     7861 aagacaattg gaaaaactag ctatctttga aagaattcaa atttaccaac gagatagaag
     7921 ttgtgtatac gattcagaag aagataaaac ttcagtagca accgttcttc atgatttact
     7981 atttggcgaa tggaatcaag ttgagaaaga gatgcttaaa tcaggagaag gaaaattgaa
     8041 agatttaact aatcgaaatg gttgttagat cttgagtttt aaaatatagt ctacttataa
     8101 cttttgttag ttgtttaagg tgggcgaaac ttttttagaa gcaaaaaacg catagtctca
     8161 ggtgttgaaa aacttgaaat tatgcgtttt cttgtgggaa gatttactcc attttcttca
     8221 ggaattgaga ttttgcccat ctcttttcat tatatttaag gatacttgaa agttatattt
     8281 tagaaaaaca attatggagt tcttaatacg gaatatagta taaatgctga ttcaaagtgg
     8341 agttttgcat gctttttgct tttgttgagt ataaaatcta ttaactaaag tcaactacaa
     8401 acattaattt aagatgaagt aaactgtaac cttcggaaat gtctcttact cgatttcaga
     8461 atgaatcact gacataggat tgaaagaact aagtatttct ttttgttttg aatgagatac
     8521 gtgagtatag atttgtgtga ttgatataga actgtgtcca agaatttgtt gaatatatcg
     8581 aatatctaca tcattatcta gaagcattgt tgcaaagcta tgtctaaaca tatgtggtgt
     8641 aatagtttta gataagccat tttgttcaac gattctcttt aaaattaaac gtacactttg
     8701 ctctgacaat ggtttaggcg aatgttttcc tgggaatagg aaatcattag attcctttcc
     8761 gtttttattt atatatgttt ctaataaatt gaaggttgtt tgatctccta aaaataggat
     8821 acgctctttc ttaccttttc ctataatatg gagtgtctta ttggaaagat taatatcttt
     8881 gagatgaatg tgacaaagtt cagaaattct gatacctgtt gaaagtaata gggaaataat
     8941 tagtagattt ctttcagctt tttgtttttg atagtcagtt ttagatataa ctactctctg
     9001 ctctaaatat gaaaaaatat ttttcagaat atcatacgga atcgttttag gcaatatttt
     9061 ttcagttcta aattgaaagc gtaattgatt gaagggattc tcttcaatta tgtgctggta
     9121 ttttagatag ttataaaaca cctttataca agcaattttt cttcttaatg tattcgtttt
     9181 tatgttagat tgtgtcaact cttcgatata ggattcgaca ttatcatagt ttgaattata
     9241 aaattgcata agatcattct tataagctcg aatcgtgtgt gaactcaaac gcttatgagt
     9301 tttgcaataa tctaagtaag tagaaataag cttataatcc ataaaaatct cctttatcaa
     9361 taatcatgct attataaacc tatttgagtg ctttgtatag tgataataaa ttgttatcgg
     9421 taggagatag cgaatatgac aaataaaaaa ataagagtat ttttaagcag acctaatcca
     9481 tttacagaga atcaaaattt atttattaaa gaattgatta aatttttaag acgacacaat
     9541 attgaatgtg taacattaca agctgctgag tatactcctt acgaagtcat gaattcgttg
     9601 agtgagatga tacaaaggag ttacggaatt ataattgttg catttggtca gacatttatt
     9661 tctagtggaa ccagaaaaat gggagctgag gataatccag acttctttgc atccaaagag
     9721 acccacttaa agaataagtg ggttacaagt gtttattgtc atattgaagg gattttagcg
     9781 ttaacttata atcttccaat gctatctatt cctcaagaaa gtttaactga agaagggatt
     9841 ttaaagaagg gagaatattc tataacatca cctgaattct cattagaaac aaaagaaaat
     9901 atattaatgt acttgcaatc agaagggttt caaaaaagtt ttcatgtatg gaaaaacctt
     9961 cttgatgata agtataactt tatcaaagga ggggaaataa actattaatt accatttaca
    10021 attgcagttt taatcctctg gagatcctca cttaacataa tactaccttc attaattgtt
    10081 tttttctgtc gttcagttaa accctcaata tcattaatag gttttgaaag aaggcctgaa
    10141 atcagcatta gatcctcttg attggaaaga aaccaaatgt cgtcatattc actagattta
    10201 cgatgtattt tttctaaaga tcctaaaata gtttttgctg tataaacaga tgtatagtag
    10261 aactccttta aaacttcaac atctttctca actaaggcta tttttaacag gttagcacag
    10321 taattccttg cacaataaat atttctatct tcaaaattca tgcctaacct atagtaatta
    10381 attgcagaca ttaagtcact cctattcttt gtaatataaa atatacgtaa gaaaatagct
    10441 ccataaatac ctaataactt atgatatgtt gtggtgttta tatctatata tttactaata
    10501 ttttgctgtg ccatttttaa atttgctagc gaagattcat ttttcttata ggatgatagt
    10561 aaatagcctg ccaaaatttc ttcatcaata tatccacttt ctaaaatttg ctgaaatatt
    10621 tcttctgcct caggatactt ttctgaattc ttgagttccg tggcttgatc ataaagttca
    10681 gctattgact tgtctaatgc ttcttcactt tgaatttcag ttttatcgat taaatcgtta
    10741 attattacac ggtatagagc agattcaaag gctggactat cagtaaatgt ctcatctgac
    10801 tttatagcgg aatcaatata ttcagaaagc agttttttca ccttgttaac ttcatccact
    10861 tcgtttaact tatcagaatc atatctgatt tgaggtaagt gtgcaatatc aaaaaagcta
    10921 atcttagctg tgtgatgatc acacagtata atggttgatt tgggtttcat agcatgacgt
    10981 agacctaact catagatagc attttggttt aaagtagtaa tatctgcaat tacaatatct
    11041 gcttttaata taccttcgat aaatgttttc gttatactct gtgtactgaa aacttcatca
    11101 gctctaaagt ggtttttacc atgaacagaa actaattctt tttctaaaat tgttggctta
    11161 attagattat tatagacttg attcaagtcc acttctatat ttgtattagg aattttttta
    11221 gtattaaacc ccataactac aaaacaactg gtcatttctc aactttcctc ccgataacaa
    11281 tttattatca ctagtatacc ataaagtcat ttttagtagc ttgatttgta taatggtttt
    11341 tttagttaga attaaatgtt attggtcaac tataaagtaa aatactgttt tgaaattata
    11401 tctaatactt ttgagtcaat tacaaactta caacaactcg agaattgtgt agtttgaagg
    11461 aaataagtac aagtttatta gaaatgtagc attttatatg attatcaaga aaaattctaa
    11521 ttttagaatt atattttcta ttagttcaga atctgttttt atttttaaat gttataatag
    11581 tgttatcaag taaaaagagc atgctataat tggtaacaat ataaaattct acgaaagaca
    11641 catggcctga caaaaacaga tttgctcgaa ttgtataaat tttacgcaat agcccttagc
    11701 tgttataaaa acggaacaag tactatttca actatttgct aggaattcat agaagatgtg
    11761 tctatgtttc aaaaatagat caaggttaag cttctgtcac tcttcaataa tgcctttttg
    11821 ggtaatagag tagggttgag gaagagatgt agaaggtggg acaggaatgg ttgtgtgaat
    11881 tagtttcagg taatggagat aagaaatgaa gttaacaaaa gtaattatta ataattttag
    11941 atcattcggt gaaagtcaaa ttattgaatt aaacaatcaa actgtactga ttgggaataa
    12001 tagttcggga aaaacaactg tattacaagc attgagtaag ctgttttcgg acaaacaaaa
    12061 tgatagaata ataaaaaaaa gtgattttca ccttccaaaa ggttcaaggc ccggagaaaa
    12121 tactagaaac ctctttatag aaactatttt tgagtttgat gaacttgatg gaactcccta
    12181 tagtcaagca attccatcgt ttttcgaaca ctttacagtt tctaaagatg gtgccaaacc
    12241 atttctacga atcaggttag aatcttcttg ggaagatgat ggaacagttg aaggaagtat
    12301 tgatactcaa ttctattata tttcatctga tgaagatact attagagatg aagacaaaca
    12361 tcgtgctcct agaaaggatt tggataaaat tagggtactt tatgtacctg cttcaagaac
    12421 gcctgagaag gagttgggta atgcttcagg tagtatgtta agtaggttgg taaatagtat
    12481 aaattggacc gaagatgaga taaatgaaat tacagataaa attgatgagt tgaataacac
    12541 ctttttatct gaaaatggag cattgactca gatcaacaat gagattcaga agtcatggga
    12601 attatatcat gaagataacc gtttttctca agcagagttg attattaatt cttctgagat
    12661 ggcggcagca cttagacaga ttgccttaaa attttcacca acaaccactg aagaagcatt
    12721 tacagtttca gatctaggag atggactgag atctattttt tatttttcac ttgttgattc
    12781 gatacttgat attgagttag aaattaccaa agaccgtgaa gaaaatcctg ataatccaag
    12841 atttaagttg attccaccag tactaactat cctagcaata gaagaaccag aaaatcatat
    12901 tgctccacat cacattggaa aactgataaa aaggtttaag caattaggca ataatgacaa
    12961 ctcccaagta attttaacgt cacattctcc agctattgta aaaagaattg acccagaaga
    13021 tttgaagtat ttaagaatag aaaataatga cagagttctt caaaccattg tttctgatat
    13081 acagctacct ccagctatag atgaatctta taaatatatt aaaggagcaa ttcaagctta
    13141 tcctgaacta tattttgcga agttagtagt tctaggtgaa ggcgacagtg aggaactgct
    13201 attaccaaag ttttttgatt tacttgggaa agaggtagat agctctcaga tttcaattgt
    13261 ccctttaggg ggcagacatg tcaactattt ttggaaatta ttgaatgctc tcagaattcc
    13321 tcatattacc ttgttggatt ttgataatga gagatacgga ggtggttggg gaagaataaa
    13381 atacatttct caacatctgt atgagctgaa cacagagttt caagaatggt tccatactca
    13441 gagacttgat tttaatgaaa ttgggtcacg aggttgtgaa tcgataggag ctcaacgtct
    13501 gattaattgg tttaataaac tcgaagaatt taatgtctac ttttcatcgc ctttagatat
    13561 tgatttcttg atgctacaac attataaaga caattatctg aatactttat ccccaataga
    13621 aggaccagtt gtttcatata atgattcgga tggaagtagt aaaaaagtga aattgagtga
    13681 tttagactgt cttgatagat tgcagttaga aggtttcaac aaacgtaaag aggaagcaat
    13741 aagagctact ttaaaagata agagtggaca tggcgatagt ttcaatgaag aagaaaaaga
    13801 attaatgatt tggtatcaat atttcttttt aggtagagga aaaccaacaa ctcatatgca
    13861 atttttatca tctattagtg atgatgaatt aacaagaaat ctaccccctg tatttgaaaa
    13921 aatagttaac agtgctgaag aattacttgg agatattcaa catggtaaag agtgaggagt
    13981 ggtttcctaa aggagatatc attttagaag agactgcatt aggagccgtc aaagatgtga
    14041 ctaactgttt agtcattgct ggaccaggtg ctgggaaaac tgaattacta gctcaaaagt
    14101 tagactatct attctctaca aataaatgcg tttctccgaa aaaaattcta gcattaagtt
    14161 tcaaaacgga tgctgcatca aatttgaaag aaagagttaa gaaacgttat ggtgatgaat
    14221 atgcttctcg ttttacctca ttaacctatt cggcttttga aaagagaatt ttagaccaat
    14281 ttagagatgt tctacctgag gatatacggc catcaagaga ttatttgatt gaagattggt
    14341 atactataaa agaactactc tctatgaatg gaattaatgt taatggatgg agaatgtcag
    14401 atataagaag atatgtcgaa aacatcatac ttaacaatgg ggataatcac aagtttaaaa
    14461 ctgacttact aaaaggaaca caagataata agccggtcct cttgtatagg caaataacaa
    14521 agttgagtac tcaaataata gatactaacg aatacatccg taaagcactt caaatgacat
    14581 acgattttgt atttctagat gaatttcagg atactacata tgcccagtat gatttattaa
    14641 aaacttgttt tttaggttcg tcttgtaaat taacagcagt tggagatgat aagcaagcca
    14701 ttatgagatg ggcaggtgca aagcctgata tttttccaga ctatattcga gactttaatc
    14761 caaatgaata tcaattgttg atgaatcacc gctctgtacc taagcttgta gaatttcaaa
    14821 aagaggttca tcagatatta aatagtaatc acagttctat tcagacaaat aattatccag
    14881 aatttcaaga gggtgaaata acattatttg aatttgaaaa tgaaagttta gaagctaagt
    14941 taattgcaaa tgatatagaa tcaaaaattc aaggaggtat acgaccatca gaaatttgta
    15001 tcctagcaaa acaaaaggtt ggtatttata gtttcgaatt gatatctata ttaaatagca
    15061 aagggattaa agcaagaatt gaaaatgaat atcaggatat tttaaaagat cctacgtgta
    15121 acctattatt agatttaata tcatgcagtc aaggaaaacg agatccttta atttgggaaa
    15181 atattagtaa tttttatgga aatatcaatg gaatagatga gttaactgat gaattaattt
    15241 tagcaaaatc ctataaggag attgacaata tagttagtga tattacttac ctaatttcaa
    15301 attttattcc caatgaagaa agtatgctaa aattaattga ttgtattatt gaaaaaatag
    15361 atgaaaaaag aattatttcc aatttttcaa catacaatgg aaaaagtgac ctagatatca
    15421 ttgtcaagaa cttttcaaag ttattataca tagaatattc tcaaacacaa ggtgaatggc
    15481 tagatacagt ctctagtttc aagggtgaaa actcaattcc aattatgact atccataaga
    15541 gtaaaggatt agaatatgag gtagtctatt ttctaggctt ggaggattct gcattctgga
    15601 gttttaataa tcagccggaa gaagataaaa gtgcattctt tgtcgcactt tcaagagcaa
    15661 aaagtcactt aatattcaca tattgtaaat tgagaaataa tagtccgcaa aataatagaa
    15721 atattaatga gatatattca ttgctgactc aatccaattt agttgatgtt attaattaat
    15781 aatgattaag gcatagaaat tagtttttta gataaactaa tttctatgcc ttgttttatc
    15841 ttttttacta gttaaaaaga ttgattatag tgggttatca agatatgttt tttgaaaact
    15901 tttcaataac ctaa
//
LOCUS       DBERMM010000044        14000 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.046, whole genome shotgun sequence.
ACCESSION   DBERMM010000044 DBERMM010000000
VERSION     DBERMM010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 14000)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14000)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14000
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.046"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..93
                     /locus_tag="ACL8AS_001735"
     CDS             <1..93
                     /locus_tag="ACL8AS_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
                     /protein_id="HGS1229554.1"
                     /translation="MFSTTYRNHRKRFGLRMNLIAGIINHELGF"
     gene            complement(284..1975)
                     /gene="argS"
                     /locus_tag="ACL8AS_001736"
     CDS             complement(284..1975)
                     /gene="argS"
                     /locus_tag="ACL8AS_001736"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015632348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HGS1229555.1"
                     /translation="MNTKELIASELASIIDSLDQEAILKLLETPKNSEMGDIAFPAFS
                     LAKVERKAPQMIATELAEKMNSQAFEKVVATGPYVNFFLDKSAISAQVLQAVTTEKEH
                     YADQNIGKQENVVIDMSSPNIAKPFSIGHLRSTVIGDSLSHIFQKIGYQTVKVNHLGD
                     WGKQFGMLIVAYKKWGDEEAVKAHPIDELLKLYVRINAEAENDPSLDEEAREWFRKLE
                     NGDEEALALWQWFRDESLVEFNRLYNELKVEFDSYNGEAFYNDKMDAVVDILSEKGLL
                     LESEGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKNEYQFAKSIYVVGQE
                     QSAHFKQLKAVLQEMGYDWSDDITHVPFGLVTKEGKKLSTRKGNVILLEPTVAEAVSR
                     AKVQIEAKNPELENKDQIAHAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYV
                     QYAYARIQSILRKADFKPETAGNYSLNDTESWEIIKLIQDFPRIINRAADNFEPSIIA
                     KFAISLAQSFNKYYAHTRILDESPERDSRLALSYATAVVLKEALRLLGVEAPEKM"
     gene            2111..2557
                     /gene="argR"
                     /locus_tag="ACL8AS_001737"
     CDS             2111..2557
                     /gene="argR"
                     /locus_tag="ACL8AS_001737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HGS1229556.1"
                     /translation="MRKRDRHQLIKKMITEEKLSTQKEIQDRLEAHNVCVTQTTLSRD
                     LREIGLTKVKKNDMVYYVLVNETEKIDLVEFLSHHLEGVARAEFTLVLHTKLGEASVL
                     ANIVDVNKDEWILGTVAGANTLLVICRDQHVAKLMEDRLLDLMKDK"
     gene            2608..5142
                     /gene="mutS"
                     /locus_tag="ACL8AS_001738"
     CDS             2608..5142
                     /gene="mutS"
                     /locus_tag="ACL8AS_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006298 - mismatch repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HGS1229557.1"
                     /translation="MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAA
                     QILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVV
                     KREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
                     VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQT
                     ASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLF
                     WLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYD
                     IERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELES
                     LISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTL
                     KIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSA
                     NLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQID
                     IRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQL
                     GSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDE
                     LGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQ
                     DGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQT
                     SAVTEHISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL"
     gene            5289..6983
                     /gene="patA"
                     /locus_tag="ACL8AS_001739"
     CDS             5289..6983
                     /gene="patA"
                     /locus_tag="ACL8AS_001739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatA"
                     /protein_id="HGS1229558.1"
                     /translation="MLIQKIKTYKWQALASLLMTGLMVASSLLQPRYLQEVLGALLTG
                     KYEAIYSIGAWLIGVAVVGLVAGGLNVVLAAYIAQGVSSDLREDAFRKIQTFSYADIE
                     QFNAGNLVVRMTNDINQIQNVVMMTFQILFRLPLLFIGSFILAVQTLPSLWWVIVLMV
                     VLIFGLTAVMMGMMGPRFAKFQTLLERINAIAKENLRGVRVVKSFVQEKEQFAKFTEV
                     SDELLGQNLYIGYAFSVVEPFMMLVGYGAVFLSIWLVAGMVQSDPSVVGSIASFVNYL
                     SQIIFTIVMVGFLGNSVSRAMISMRRIREILDAEPAMTFKDIPDEELVGSLSFENVTF
                     TYPMDKEPMLKDVSFTIEPGQMVGVVGATGAGKSTLAQLIPRLFDPQDGAIKIGGKDI
                     REVSEGTLRKTVSIVLQRAILFSGTIADNLRQGKGNATLFEMERAANIAQASEFIHRM
                     EKTFESPVEERGTNFSGGQKQRMSIARGIVSNPRILIFDDSTSALDAKSERLVQEALN
                     KDLKGTTTIIIAQKISSVVHADKILVLNQGRLIGQGTHADLVANNAVYREIYETQK"
     gene            complement(7128..7583)
                     /locus_tag="ACL8AS_001740"
                     /pseudo
     CDS             complement(7128..7583)
                     /locus_tag="ACL8AS_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942960.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            7775..9541
                     /gene="patB"
                     /locus_tag="ACL8AS_001741"
     CDS             7775..9541
                     /gene="patB"
                     /locus_tag="ACL8AS_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatB"
                     /protein_id="HGS1229559.1"
                     /translation="MKTVQFFWHYFKVYKFSFVVVILMIVLATFAQALFPVFSGQAVT
                     QLANLVQAYQNGNPELVWQSLSGIMVNLGLLVLVLFISSVIYMCLMTRVIAESTNEMR
                     KGLFGKLAQLTVSFFDRRQDGDILSHFTSDLDNILQAFNESLIQVMSNIVLYIGLILV
                     MFSRNVTLALITIASTPLAFLMLIFIVKMARKYTNLQQKEVGKLNAYMDESISGQKAV
                     IVQGIQEDMMAGFLEQNERVRKATFKGRMFSGILFPVMNGMSLINTAIVIFAGSAVLL
                     NDKSIETSTALGLIVMFAQFSQQYYQPIIQVAASWGSLQLAFTGAERIQEMFDAEEEI
                     RPEKAPTFTKLQESVEISHIDFSYLPDKPILKDVSISAPKGQMTAVVGPTGSGKTTIM
                     NLINRFYDVDAGGIYFDGKDIRGYDLDSLRSKVGIVLQDSVLFSGTIRDNIRFGVSDA
                     SQEMVEVAAKATHIHDYIESLPDKYDTLIDDDQSIFSTGQKQLISIARTLMTDPEVLI
                     LDEATSNVDTVTESKIQHAMEVVVAGRTSFVIAHRLKTILNADQIIVLKDGEVIERGN
                     HHELLKLGGFYSELYHNQFVFK"
     gene            9680..10369
                     /locus_tag="ACL8AS_001742"
     CDS             9680..10369
                     /locus_tag="ACL8AS_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HGS1229560.1"
                     /translation="MARTVVGVAANLCPVDAEGKIIHSSVSCRFAEIIRQVGGLPLVI
                     PVGDESVVRDYVEMIDKLILTGGQNVHPQFYGEKKTVESDDYNLVRDEFELALLKEAL
                     RQNKPIMAICRGVQLVNVAFGGTLNQEIEGHWQGLPFGTSHSIETVEGSVVAKLFGKE
                     SQVNSVHRQSIKDLAPNFRVTAIDSRDQTIEAIESIDEHRIIGLQWHPEFLVNEEDGN
                     LELFEYLLNEL"
     gene            10373..10552
                     /locus_tag="ACL8AS_001743"
     CDS             10373..10552
                     /locus_tag="ACL8AS_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229561.1"
                     /translation="MEHLVVLSFIFSKFLECGILRKRLNSDKNWRNSTKKLEKNEGKR
                     YDRKEEILEEEHVTY"
     gene            10539..11888
                     /locus_tag="ACL8AS_001744"
     CDS             10539..11888
                     /locus_tag="ACL8AS_001744"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004347 - glucose-6-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HGS1229562.1"
                     /translation="MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSD
                     FLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFAN
                     LQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFK
                     ELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWETFVVPDDIGGRFSVLTAVGLL
                     PIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEP
                     SLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDK
                     PRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAF
                     TLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL"
     gene            12012..13472
                     /gene="gltX"
                     /locus_tag="ACL8AS_001745"
     CDS             12012..13472
                     /gene="gltX"
                     /locus_tag="ACL8AS_001745"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004818 - glutamate-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HGS1229563.1"
                     /translation="MSKDIRVRYAPSPTGLLHIGNARTALFNYLYARHHGGTFLIRIE
                     DTDRKRHVEDGERSQLENLRWLGMDWDESPESHENYRQSERLDLYQKYIDQLLAEGKA
                     YKSYVTEEELAAERERQEVAGETPRYINEYLGMSEEEKAAYIAEREAAGIIPTVRLAV
                     NESGIYKWHDMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVIDDHDMQISHVIRGD
                     DHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYL
                     PEAVFNFIALLGWNPGGEDEIFSREELIKLFDENRLSKSPAAFDQKKLDWMSNDYIKN
                     ADLETIFEMAKPFLEEAGRLTDKAEKLVELYKPQMKSVDEIIPLTDLFFSDFPELTEA
                     EREVMTGETVPTVLEAFKAKLEAMTDDEFVTENIFPQIKAVQKETGIKGKNLFMPIRI
                     AVSGEMHGPELPDTIFLLGREKSIQHIENMLKEISK"
     gene            13486..13920
                     /locus_tag="ACL8AS_001746"
     CDS             13486..13920
                     /locus_tag="ACL8AS_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HGS1229564.1"
                     /translation="MDIWEKMYEEAQKLYNPHEVSDFVYANHVVAAVEAGDGQIFTGF
                     CMEGTCGVFHLCAERAALFNMYQFSGQTKVKKVLAFRDKPPYGGSSAMPCGACREFLL
                     EFNAENKDAEFMMDYNIRKTVKVAELIPYWWGEERASKFNER"
BASE COUNT         4092 a         2701 c         3156 g         4051 t
ORIGIN      
        1 atgttttcaa caacctatcg aaatcatcgt aaacgctttg gattacgaat gaatttgatt
       61 gctggtatta tcaatcatga actaggattc tagttttgca ggaagtctat tatttggtta
      121 ggtgaattag tgaagcgttt aggcaagtgt ctctggttac gacgtcatgg cctctaaatc
      181 gattatattt aggggtcatg actagtgaag cgcctagcca aagtccgaat aggatttggc
      241 gttagttact tagattgctt tgcaatcaag taactttggc gatttacatc ttctctggcg
      301 cttctactcc aagcaagcga agggcttctt tgagaacgac tgcggttgcg tagctgaggg
      361 ctagacggct gtcgcgttct gggctttcat ccaagatacg tgtatgtgca tagtatttgt
      421 taaaggattg agccaggcta attgcaaatt tagcaatgat agaaggttca aagttatctg
      481 ccgcacggtt gataatacgt gggaagtctt gaatgagttt aataatttcc cagctttcag
      541 tatcattcaa gctatagttg ccagctgttt ctggtttgaa atcggctttg cgtaagatag
      601 attggatacg agcgtaggca tattgaacgt aaggtccagt ttcaccctcg aaggatacca
      661 tagcttctag gtcgaagtcg tatccatttg tacggtcggt tttgaggtca tagaatttaa
      721 tggctccaac cccaacagca tgtgctattt ggtctttgtt ttctagttca ggatttttag
      781 cctcgatttg gaccttggca cggctaacag cctctgcaac agtaggctct agcaagatga
      841 cattcccttt acgagtagag agcttcttcc cttcttttgt aaccagacca aaaggaacgt
      901 gggtaatgtc gtcactccaa tcgtagccca tctcttgcaa gacagctttg agctgtttaa
      961 agtgggcaga ttgttcttga ccaacgacgt agatagattt agcaaattgg tattcatttt
     1021 tacggtagag ggctgcagct aagtcacgtg tgatatagag agttgcacca tcagacttct
     1081 tgatgagggc tggatgttca attccatatt tctcaagatt cacaacttgg gcaccttctg
     1141 attcaagaag tagtcctttt tcagaaagaa tgtctacaac tgcatccatc ttatcattgt
     1201 agaaggcttc tccgttatag ctgtcaaatt caaccttcaa ttcattgtaa aggcggttaa
     1261 attccactaa actttcatcg cggaaccatt gccaaagagc gagagcttcc tcatctccat
     1321 tttcaagttt acggaaccat tcgcgcgctt cttcatccaa gctagggtca ttttcagctt
     1381 cagcgttgat gcggacatag agtttaagga gttcatcgat tggatgagct tttacagctt
     1441 cttcgtcgcc ccattttttg taggcaacaa tcaacattcc aaattgttta ccccagtctc
     1501 ccaaatggtt gaccttgacc gtttgataac cgattttttg gaaaatatgt gacaagctat
     1561 ctccgataac agttgaacgc aggtggccaa tagaaaatgg tttagcgata ttcggactag
     1621 acatgtcgat aacaacattt tcttgtttac caatattttg gtcagcatag tgttcttttt
     1681 cagtggtaac agcttgcaat acttgagcag aaatggcaga tttatcaagg aaaaagttaa
     1741 cgtaaggtcc tgttgcgaca actttttcaa aggcctggct gttcattttt tcagccagtt
     1801 cagtcgcaat catttgtggt gctttacgtt cgactttggc aagagaaaaa gcagggaaag
     1861 cgatgtcacc catttctgag tttttagggg tttccagtaa ctttaaaata gcctcttggt
     1921 ccaggctatc aatgatgcta gccaattcgc tagcaatcaa ttcttttgta ttcattaaga
     1981 gctccttttt ggacttttct actattttat cacaatttta aagaaagaag aaaaaatttt
     2041 tgaaatctcc tgtttttttg gtataatatg gttataaata tagttataaa tatgcacgca
     2101 agaggatttt atgagaaaaa gagatcgtca tcagttaata aaaaaaatga ttactgagga
     2161 gaaattaagt acacaaaaag aaattcaaga tcggttggag gcgcacaatg tttgtgtgac
     2221 gcagacaacc ttgtctcgtg atttgcgcga aatcggcttg accaaggtca agaaaaatga
     2281 tatggtgtat tatgtactag taaatgagac agaaaagatt gatttggtgg aatttttgtc
     2341 tcatcattta gaaggtgttg caagagcaga gtttaccttg gtgcttcata ccaaattggg
     2401 agaagcctct gttttggcaa atattgtaga tgtaaacaag gatgaatgga ttttaggaac
     2461 agttgctggt gccaatacct tattggttat ttgtcgagat cagcacgttg ccaaactcat
     2521 ggaagatcgt ttgctagatt tgatgaaaga taagtaaggt cttgggagtt gctctcaaga
     2581 cttatttttg aaaaggagag acagaaaatg gcgatagaaa agctatcacc cggcatgcaa
     2641 cagtatgtgg atattaaaaa gcaatatcca gatgcttttt tgctctttcg gatgggtgat
     2701 ttttatgaat tattttatga ggatgcggtc aatgctgcgc agattctgga aatttcctta
     2761 acgagtcgca acaagaatgc cgacaatccg atccctatgg cgggtgttcc ctatcattct
     2821 gcccaacagt atatcgatgt cttgattgag cagggttata aggtggctat cgcagagcag
     2881 atggaagatc ctaaacaagc agttggggtt gttaaacgag aggttgttca ggtcattacg
     2941 ccagggacag tggtcgatag cagtaagccg gacagtcaga ataatttttt ggtttccata
     3001 gaccgcgaag gcaatcaatt tggcctagct tatatggatt tggtgacggg tgacttttat
     3061 gtgacaggtc ttttggattt cacgctggtt tgtggggaaa tccgtaacct caaggctcga
     3121 gaagtggtgt tgggttatga cttgtctgag gaagaagaac aaatcctcag ccgccagatg
     3181 aatctggtac tctcttatga aaaagaaagc tttgaagacc ttcatttatt ggatttgcga
     3241 ttggcaacgg tggagcaaac ggcatctagt aagctgctcc agtatgttca tcggactcag
     3301 atgagggaat tgaaccacct caaacctgtt atccgctacg aaattaagga tttcttgcag
     3361 atggattatg cgaccaaggc tagtctggat ttggttgaga atgctcgctc aggtaagaaa
     3421 caaggcagtc ttttctggct tttggatgaa accaaaacgg ctatggggat gcgtctcttg
     3481 cgttcttgga ttcatcgccc cttgattgat aaggaacgaa tcgtccaacg tcaagaagta
     3541 gtgcaggtct ttctcgacca tttctttgag cgtagtgact tgacagacag tctcaagggt
     3601 gtttatgaca ttgagcgctt ggctagtcgt gtttcttttg gcaaaaccaa tccaaaggat
     3661 ctcttgcagt tggcgactac cttgtctagt gtgccacgga ttcgtgcgat tttagaaggg
     3721 atggagcaac ctactctagc ctatctcatc gcacaactgg atgcaatccc tgagttggag
     3781 agtttgatta gcgcagcgat tgctcctgaa gctcctcatg tgattacaga tgggggaatt
     3841 atccggactg gatttgatga gactttagac aagtatcgtt gcgttctcag agaagggact
     3901 agctggattg ctgagattga ggctaaggag cgagaaaact ctggtatcag cacgctcaag
     3961 attgactaca ataaaaagga tggctactat tttcatgtga ccaattcgca actaggaaat
     4021 gtgccagccc actttttccg caaggcgacg ctgaaaaact cagaacgctt tggaaccgaa
     4081 gaattagccc gtatcgaggg agatatgctt gaggcgcgtg agaagtcagc caacctcgaa
     4141 tacgaaatat ttatgcgcat tcgtgaagag gtcggcaagt acatccagcg tttacaagct
     4201 ctagcccaag gaattgcgac ggttgatgtc ttacagagtc tggcggttgt ggctgaaacc
     4261 cagcatttga ttcgacctga gtttggtgac gattcacaaa ttgatatccg gaaagggcgc
     4321 catgctgtcg ttgaaaaggt tatgggggct cagacctata ttccaaatac gattcagatg
     4381 gcagaagata ccagtattca actgattaca gggccaaaca tgagtgggaa gtctacctat
     4441 atgcgtcagt tagccatgac ggcggttatg gcccagctgg gttcctatgt tcctgctgaa
     4501 agcgcccatt taccgatttt tgatgcgatt tttacccgta tcggagcagc agatgacttg
     4561 gtttcgggtc agtcgacctt tatggtggag atgatggagg ccaataatgc catttcgcat
     4621 gcgaccaaga actctctcat tctctttgat gaattgggac gtggaactgc aacttatgac
     4681 gggatggctc ttgctcagtc catcatcgaa tatatccatg agcacatcgg agctaagacc
     4741 ctctttgcga cccactacca tgagttgact agtctggagt ctagtttaca acacttggtc
     4801 aatgtccacg tggcaactct ggagcaggat gggcaggtta ccttccttca caagattgaa
     4861 ccgggaccag ctgataaatc ctacggtatc catgttgcca agattgctgg cttgccagca
     4921 gaccttttag caagggcgga taagattttg actcagctag agaatcaagg aacagagagt
     4981 cctcctccca tgagacaaac tagtgctgtc actgaacata tttcactctt tgatagggca
     5041 gaagagcatc ctatcctagc agaattagct aaactggatg tgtataatat gacacctatg
     5101 caggttatga atgtcttagt agagttaaaa cagaaactat aaaaccaaga ctcactagtt
     5161 aatctagctg tatcaaggag acttctttga caattctcca cttttttgct agaataacat
     5221 cacacaaaca gaatgaaaag gagctgacgc attgtcgctc ccttttgtct attttttaag
     5281 gagaaagtat gctgattcag aaaataaaaa cctacaagtg gcaggccctg gcttcgctcc
     5341 tgatgacagg cttgatggtt gctagttcac ttctgcaacc gcgttatctg caggaagtct
     5401 taggcgccct ccttactggg aaatatgaag ctatttatag tatcggggct tggttgattg
     5461 gtgtggccgt agtcggtcta gttgctggtg gactcaatgt tgtcctcgca gcctatattg
     5521 cccaaggagt ttcatccgac cttcgggagg atgccttccg taaaattcaa accttttctt
     5581 atgctgatat tgaacaattt aatgcgggaa atctagtcgt tcgaatgaca aatgatatca
     5641 accagattca gaacgttgtc atgatgacct tccaaattct tttcagactt cccctcttgt
     5701 tcatcggttc gtttatccta gcggttcaaa ccttaccttc tctgtggtgg gtgattgttc
     5761 tcatggtagt cttgattttt ggtttgactg ctgtcatgat gggaatgatg gggcctcgtt
     5821 ttgccaagtt tcaaaccctt cttgagcgca tcaatgccat tgccaaggaa aatttacgtg
     5881 gcgttcgtgt ggtcaagtcc tttgtccaag aaaaagagca atttgctaag tttacagagg
     5941 tctcagacga gcttcttggt caaaaccttt acattggtta tgccttttca gtagtggaac
     6001 cctttatgat gttggttggt tacggggcgg tcttcctctc tatttggctg gtcgcgggaa
     6061 tggttcagtc ggatccgtct gttgttggtt ccatcgcttc ttttgttaat tacctaagcc
     6121 agattatctt taccattgtt atggttggat ttttgggaaa ttctgtcagc cgtgccatga
     6181 tttccatgcg tcgtattcga gaaattcttg acgcagagcc agctatgacc ttcaaggata
     6241 tcccagatga agagttggtt ggaagtctta gctttgaaaa tgtgaccttt acctatccaa
     6301 tggacaagga accgatgctg aaagatgtga gctttactat tgaacctggt caaatggttg
     6361 gtgtagttgg agcgactggt gcaggaaagt caaccttggc tcaattgatt ccacgtctct
     6421 ttgatccaca ggacggggcc attaaaatcg gtggcaagga tattcgagaa gtgagtgaag
     6481 gaaccctgcg taaaacagtt tccatcgttc tccaacgtgc cattcttttt agtggaacga
     6541 ttgcagataa cttgagacag gggaagggga atgctactct atttgaaatg gagcgcgcag
     6601 ccaatattgc ccaggctagt gaattcattc atcgtatgga gaaaaccttt gaaagtccag
     6661 ttgaagaacg gggaaccaat ttctctggtg gacaaaaaca aaggatgtcg attgcgcgtg
     6721 ggattgtcag caatccacgt attctgattt ttgatgattc gacctcagcc ttggatgcca
     6781 aatcagagcg cttggtgcaa gaagctttga ataaggactt gaaggggacg acaaccatta
     6841 ttattgctca aaaaattagc tcggttgtcc atgcagacaa gatcttggtt ctaaatcaag
     6901 gacgattgat tggtcaaggt acgcatgcag acttggttgc caacaatgcc gtttaccgtg
     6961 aaatctatga aacacagaaa tgaaagacaa actataagaa aagtcaatag ttttatctaa
     7021 actatttctt atttcaattt gatgatttgg cgatgatttt agagcacggc aaaaggccct
     7081 tgaaaaagtc cattttttca aaggtaatcc tgtgttaatt tcagaaatta catcactttt
     7141 tgttcgtcaa atggcagctc tttttttagg atataaaaca gggttcggat aagttttttt
     7201 gcaaggtgga tgatggctac attgtaatgt tttccttgtt ctaatttagt cttaagatag
     7261 gccttaaaag caggcgaaaa gcgagggcat gctttggcag cttgtatgag tacctaccgc
     7321 agatgagggg aactccgttt gaccattctt cctgctaaat caatctgacc tgactgataa
     7381 atagaagaat ccagtccagc gaaagcttgt aattgagcag gattatcaaa ggcatgaata
     7441 tttcgaatct cagctaaaat gaccgcccct aaacgatccc caatcccagt acccgtcgtg
     7501 atgaccgagt tgaactcagc catcaagtca ttgacacatg tttccgcctt gtcaatgagc
     7561 ctcttgtaat gtttgatgtt ttcattacac gagataaaac gtctatgcgt tatcaaactc
     7621 attaccaatt aaaacaaaaa gctgtggtta gatcctttcg gaaattgtca agcgattgga
     7681 ggaaatgaac taatccacag cggcttattc caagtatacc acttgggctt tggcagtagc
     7741 taactgcgct aaatataata taaggaggag taaaatgaag acagttcaat ttttttggca
     7801 ttattttaag gtctacaagt tctcatttgt agttgtcatc ctgatgattg ttctggcgac
     7861 ttttgcccaa gccctctttc cagtcttttc tggacaagcg gtgacgcagc tagccaattt
     7921 agttcaagct tatcaaaatg gcaatccaga acttgtatgg caaagcctat caggaatcat
     7981 ggtcaatctt ggcctgctgg ttttggttct atttatctct agtgtaatat acatgtgtct
     8041 catgacgcgc gtgattgcag aatcgaccaa cgagatgcgc aaaggcctct ttggtaagct
     8101 tgctcagttg acggtttctt tctttgaccg tcgacaagat ggcgatatcc tgtctcattt
     8161 taccagtgat ttggataata tcctccaagc ctttaacgaa agcttgattc aggtcatgag
     8221 caatattgtt ttatacattg gtctgattct tgtcatgttt tcgagaaatg tgacgctggc
     8281 tctcatcacc attgccagca ccccattggc tttccttatg ctgattttca tcgtgaaaat
     8341 ggcacgcaaa tacaccaacc tccagcagaa agaggtaggg aagctcaacg cctatatgga
     8401 tgagagcatc tcaggccaaa aagccgtgat tgtgcaagga attcaagagg atatgatggc
     8461 aggatttctt gaacaaaatg agcgcgtgcg caaggcaacc tttaaaggaa gaatgttctc
     8521 aggaattctt ttccctgtca tgaatgggat gagcctgatt aatacagcca tcgtcatctt
     8581 tgctggttcg gctgtacttt tgaatgataa gtctattgaa acaagtacag ccctaggttt
     8641 gattgttatg tttgcacaat tttcacagca gtactaccag cctattatcc aagttgcagc
     8701 gagttgggga agccttcagt tggcctttac tggagctgaa cgaattcagg aaatgtttga
     8761 tgcagaggag gaaatccgac ctgaaaaggc tccaaccttc actaagttgc aagaaagtgt
     8821 tgaaatcagt catatcgatt tttcatactt gcctgataaa cctattttga aagatgtcag
     8881 catttctgcc cctaaaggcc agatgacagc agttgttggg ccgacaggtt caggaaaaac
     8941 gactattatg aacctcatca atcgctttta tgatgttgat gctggtggta tttattttga
     9001 tggtaaagac attcgtggct atgacttaga tagtcttaga agcaaggtgg gaattgtatt
     9061 gcaagattcg gtcttgttta gcggaacgat tagagacaat atccgatttg gtgtgtcaga
     9121 tgctagtcag gaaatggttg aggtagcagc aaaagcaacc cacattcacg actatatcga
     9181 aagtttgcct gataagtacg atactcttat tgatgatgac cagagcatct tttcaacagg
     9241 gcagaagcaa ttgatttcaa tcgctcgaac cctgatgaca gatccagaag ttctcattct
     9301 cgatgaagca acttcaaacg tagatacggt gacagaaagc aagattcagc atgccatgga
     9361 ggtggttgta gcaggtagaa ctagtttcgt cattgcccac cgcttgaaaa ccattctcaa
     9421 tgcagatcag attattgtcc ttaaagatgg agaagtcatt gaacgtggta accaccatga
     9481 acttttgaag ctaggtggct tttattcaga actctatcac aatcaatttg ttttcaaata
     9541 agaaagaagt tgtcctatgt gggcagcttt ttcttgtcca taaaaaatgt ttatcacagc
     9601 cttaaaaaaa acatattaga cgaaagtcat tttgagtgat atgataggac tatcgttagc
     9661 attcgaaagg agaggcatca tggctagaac ggttgtagga gttgctgcaa atctatgtcc
     9721 cgtagacgca gaaggcaaaa tcattcattc atctgtatct tgtagattcg cagagatcat
     9781 tcgtcaagtc ggtggtctcc ctttagtcat tcctgttggt gatgagtcag ttgtacgtga
     9841 ttatgtggaa atgattgaca aactcatttt gacaggaggc caaaatgttc atcctcagtt
     9901 ttatggagag aaaaagaccg tcgaaagcga tgattacaat ctggtccgtg acgaatttga
     9961 attggcactc ttgaaggaag cgcttcgtca gaataaacca attatggcaa tctgtcgcgg
    10021 tgtccaactt gtcaatgttg cctttggtgg aaccctcaat caagaaatcg aaggtcactg
    10081 gcaaggacta cctttcggga catctcactc tattgagaca gtagaaggaa gcgtggtggc
    10141 taagctattt gggaaagaaa gtcaggtcaa ctcagtccat cgtcaaagca ttaaagattt
    10201 ggcacctaat ttccgtgtaa ctgctattga ttcaagagac caaactattg aagcgattga
    10261 gtctatcgac gagcaccgca ttatcggttt acagtggcat ccagagtttc tggttaatga
    10321 agaagatggc aatttagaat tatttgagta tttattgaat gaactgtaac gattggaaca
    10381 tctggtcgtt ctttctttta ttttttcaaa atttttagaa tgtggcattt tacgcaaacg
    10441 tttgaattct gataaaaatt ggagaaattc gacaaaaaaa cttgaaaaaa acgaaggtaa
    10501 gcgttatgat agaaaagaag aaatattgga ggaagaacat gtcacatatt aaatttgatt
    10561 attcaaaagt tttagacaaa tttgttgcac cacatgaagt ggaatacatg caatcacaag
    10621 taacagcagc agatgaattg atccgtaaag gaactggtgc tggtagcgac ttcttgggat
    10681 ggttggacct tcctgaaaaa tacgatcgcg aagaatttga ccgcatcttg aaagctgctg
    10741 agcaaatcaa gtcagacagc gatgttttgg ttgtgatcgg tattggtgga tcttaccttg
    10801 gtgcaaaagc agcaatcgac ttcttgaatc accattttgc taacttgcaa acaaaagaag
    10861 aacgcaaagc tccacaaatc ctttacgcag gaaactcaat ctcatctact taccttgctg
    10921 acttggtaga gtatgttgca gacaaagact tctcagtaaa cgtaatttct aaatcaggta
    10981 caacaactga accagcgatt gctttccgtg tctttaaaga actcttggtt aagaaatacg
    11041 gtcaagaaga agctaacaaa cgtatctatg caacaactga ccgccaaaag ggtgctgtta
    11101 aggttgaagc agacgctaac ggttgggaaa catttgttgt tccagatgat atcggtggac
    11161 gcttctcagt attgacagcc gttggtttgc ttccaatcgc agcatcagga gctgacatca
    11221 aagctcttat ggaaggtgcg aatgcagctc gcaaagacta cacttcagac aaaatctctg
    11281 aaaacgaagc ttaccaatac gcagccgttc gtaacatcct ttatcgtaaa ggctatgcaa
    11341 ctgagatctt ggtaaactat gagccatcac ttcaatactt ctcagaatgg tggaaacaat
    11401 tggctggtga atcagaagga aaagaccaaa aaggtatcta cccaacttca gccaacttct
    11461 caactgactt gcactcactt ggtcaattta tccaagaagg aactcgtatc atgtttgaaa
    11521 cagttgtccg tgttgacaaa cctcgtaaaa acgtgcttat tcctactttg gaagaagacc
    11581 ttgacggact tggttacctt caaggaaaag acgttgactt tgtaaacaaa aaagcaactg
    11641 acggtgttct tcttgcccac acagatggtg atgtaccaaa catgtatgtg actcttccag
    11701 agcaagacgc tttcactctt ggttacacta tatacttctt cgaattggca attgcccttt
    11761 caggttactt gaatgctatc aacccatttg accaaccagg tgttgaagct tataaacgta
    11821 acatgtttgc ccttcttgga aaaccaggat ttgaagaatt gagtaaagaa cttaacgcac
    11881 gtctataata gaagaaaaga gtggtttgcc cactcttttt actctcttta tccatagaaa
    11941 ttggactcag ccaagacttg tgatataata tagaaagcaa aaaggcagac gcctagataa
    12001 taggagaaac tatgtcaaaa gatatccgcg tacgttacgc accaagtcca acaggactac
    12061 tacacatcgg aaatgctcgt acagcattgt ttaattactt gtatgcgcgc catcatggtg
    12121 gaacatttct catccgtatc gaagatactg accgtaaacg ccatgtcgag gatggtgaac
    12181 gttcacaact tgaaaacctt cgctggttag gcatggattg ggatgaaagt ccagaatcac
    12241 atgagaatta tcgccagtct gagcgtttag acttgtatca aaaatacatt gaccaactat
    12301 tagctgaagg aaaagcctat aaatcttacg ttacagaaga agagttggca gctgaacgcg
    12361 aacgccaaga agtagctggc gaaacaccac gctacatcaa tgaatacctt ggtatgagtg
    12421 aagaagaaaa agcagcttac atcgcagaac gtgaagcagc agggatcatc ccaactgttc
    12481 gtttggctgt caatgagtca ggtatctaca agtggcatga tatggtcaaa ggcgatatcg
    12541 aatttgaagg tggcaatatc ggtggtgact gggttatcca aaagaaagac ggttacccaa
    12601 cttacaactt tgccgttgtt atcgatgacc acgatatgca aatctctcat gttatccgtg
    12661 gagatgacca tattgctaat acaccaaaac agcttatggt ctatgaagct cttggttggg
    12721 aagctccaga gttcggtcac atgaccttga ttatcaactc tgagactggt aagaagttat
    12781 ctaaacgtga tactaataca cttcaattta tcgaagatta ccgaaagaaa ggttaccttc
    12841 cagaagcagt ctttaacttt attgctcttc ttggttggaa cccaggtggt gaagatgaga
    12901 ttttctctcg tgaagaactc attaaacttt ttgatgaaaa ccgcctcagc aagtcaccag
    12961 cagcctttga tcagaaaaaa ctagactgga tgagcaatga ttatatcaag aatgcagacc
    13021 ttgaaaccat ctttgaaatg gcaaaaccat tcttagagga agcaggccgt ttgactgaca
    13081 aggctgaaaa attagttgag ctctataaac cacaaatgaa atcagtagat gagattatcc
    13141 cattgacaga tcttttcttc tcagatttcc cagaattgac agaagcagag cgcgaagtca
    13201 tgacgggtga aacagttcca acagttcttg aagcattcaa agcaaaactt gaagcgatga
    13261 cagatgatga atttgtgaca gaaaatatct tcccacaaat taaagcagtc caaaaagaaa
    13321 caggtattaa agggaaaaat cttttcatgc ctattcgtat cgcagtttca ggcgaaatgc
    13381 atgggccaga attaccagat acaattttct tgcttggacg tgaaaaatca attcagcata
    13441 tcgaaaacat gctaaaagaa atctctaaat aaagaggata caataatgga catctgggaa
    13501 aagatgtacg aagaagcaca gaaactatac aatccacatg aagtatcaga ctttgtttat
    13561 gccaatcatg ttgtagctgc agtagaagca ggagatggac aaatatttac aggattctgt
    13621 atggagggaa cctgtggtgt tttccatctc tgcgcagaac gggcggccct cttcaatatg
    13681 taccaatttt caggacaaac taaggttaag aaagtattag cctttcgaga caaaccacct
    13741 tatggtggaa gttcagccat gccttgcggt gcttgtagag aattcctttt agagtttaat
    13801 gctgaaaata aagatgcaga attcatgatg gactataata taagaaaaac agttaaagtc
    13861 gcagaactaa tcccttattg gtggggagaa gaacgtgctt ctaagtttaa tgagcgatag
    13921 aagagtcagt ataattctgg ctttttttac tataagttga aaaaataaaa aaaaattaga
    13981 aaaagtagtt gacaaagttt
//
LOCUS       DBERMM010000045        13878 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.047, whole genome shotgun sequence.
ACCESSION   DBERMM010000045 DBERMM010000000
VERSION     DBERMM010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13878)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13878)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13878
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.047"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..905
                     /locus_tag="ACL8AS_001747"
     CDS             <1..905
                     /locus_tag="ACL8AS_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003090086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HGS1229565.1"
                     /translation="EEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTF
                     ERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYE
                     AGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDI
                     VKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQG
                     SVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEM
                     SGAGLKESHPHDVQITNEAPNYSM"
     gene            complement(956..2053)
                     /gene="recF"
                     /locus_tag="ACL8AS_001748"
     CDS             complement(956..2053)
                     /gene="recF"
                     /locus_tag="ACL8AS_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000266665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HGS1229566.1"
                     /translation="MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIY
                     FLALTRSHRTRTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQA
                     RLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQR
                     NTYLKSDQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEEL
                     SISYQSSVNITDKQNLSESFKIALEKSRSRDLFKKNTGVGPHRDDISFYINGMDASFG
                     SQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTF
                     ITTTSLDHLQNLPENLSIFTIQDGKAAVNGN"
     gene            complement(2056..2424)
                     /gene="yaaA"
                     /locus_tag="ACL8AS_001749"
     CDS             complement(2056..2424)
                     /gene="yaaA"
                     /locus_tag="ACL8AS_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HGS1229567.1"
                     /translation="MEYKLFEEFITLQALLKELGITHSGGAIKSFLSEHSVYFNRELE
                     SRRGKKLRIGDKVDIPDMNIDILLTQPTSEEQDEYQADKVEKERIAKLVKKMNKGVKK
                     DKSKPASSPKSQQAPRFPGR"
     gene            2583..3833
                     /locus_tag="ACL8AS_001750"
     CDS             2583..3833
                     /locus_tag="ACL8AS_001750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M16 family metallopeptidase"
                     /protein_id="HGS1229568.1"
                     /translation="MELVHGISTHFIQSKKFKTNKITVRFTAPLSLDTIAGHMLSASM
                     LETANQMYPTSQDLRRHLASLYGTDMSTNCFRRGQSHIIELTFTYVRDEFLSRKNVLT
                     SQILELVKETLFSPVVVDNGFDPALFEIEKKQLLASLAADMDDSFYFAHKELDKLFFH
                     DERLQLEYSDLRNRILAETPQSSYSCFQEFLANDRIDFFFLGDFNEVEIQNVLESFGF
                     KGRKGDVKVQYCQPYSNILQEGMVRKNVGQSILELGYHYRSKYGDEQHLPMIVMNGLL
                     GGFAHSKLFTNVRENAGLAYTISSELDLFSGFLRMYAGINRENRNQARKMMNNQLLDL
                     KKGYFTEFELNQTKEMIRWSLLLSQDNQSSLIERAYQNALFGKSSADFKSWIAKLEQI
                     DKDAICRVANNVKLQAIYFMEGIE"
     gene            3830..5113
                     /locus_tag="ACL8AS_001751"
     CDS             3830..5113
                     /locus_tag="ACL8AS_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M16 family metallopeptidase"
                     /protein_id="HGS1229569.1"
                     /translation="MTKVVFEEKYYPAVKEKVYRTRLANGLTVALLPKKEFKEVYGSV
                     TVQFGSIDTLVTEVDGDVKQYPGGIAHFLEHKLFEREDSSDLMSAFTSLGADSNAFTS
                     FTKTNYLFSATDYFLENLYLLDELVTSAHFTEASILTEQDIIQQEREMYQDDPDSCLF
                     FSTLANLYPGTPLATDIVGSEESISQINLTNLQENFTKFYKPVNMSLFLVGNFDVERV
                     QDYFESKELKDSDFQEVAREKWFLQPVKPTDSMRMEVSSPKLAIGVRGKREVSEADCY
                     RHHILLKLLFAMMFGWTSDRFQKCYESGKIDASLSLEVEITSRFHFVMLTMDTKEPVA
                     LSHQFRKAIRNFTKDLDITEEHLDIIKREMFGEFFSSMNSLEFIATQYDAFENGETIF
                     DLPKILQEITLEDVLDAGHHLIDDGDIVDFTIFPS"
     gene            5155..5976
                     /gene="rodZ"
                     /locus_tag="ACL8AS_001752"
     CDS             5155..5976
                     /gene="rodZ"
                     /locus_tag="ACL8AS_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytoskeleton protein RodZ"
                     /protein_id="HGS1229570.1"
                     /translation="MRKKTIGEVLRLARINQGLSLDELQKKTEIQLDMLEAMEADDFD
                     QLPSPFYTRSFLKKYAWAVELDDQIVLDAYDSGSMITYEEVDVDEDELTGRRRSSKKK
                     KKKTSFLPLFYFILFALSILIFVTYYVWNYIQTQPEEPSLSNYSVVQSTSSTSSVPHS
                     SSSSSSSIESAISVSGEGNHVEIAYKTSKETVKLQLAVSDVTSWVSVSESELEGGVTL
                     SPKKKSAEATVATKSPVTITLGVVKGVTLTVDNQTVDLSKLTAQTGQITVTFTKN"
     gene            5987..6532
                     /gene="pgsA"
                     /locus_tag="ACL8AS_001753"
     CDS             5987..6532
                     /gene="pgsA"
                     /locus_tag="ACL8AS_001753"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008444 -
                     CDP-diacylglycerol-glycerol-3-phosphate
                     3-phosphatidyltransferase activity [Evidence IEA];
                     GO_process: GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HGS1229571.1"
                     /translation="MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVA
                     SITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRE
                     LAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
                     YSGYDYFKGSAYVFKGTFGSK"
     gene            6529..7356
                     /locus_tag="ACL8AS_001754"
     CDS             6529..7356
                     /locus_tag="ACL8AS_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     ATP-binding protein"
                     /protein_id="HGS1229572.1"
                     /translation="MKSIIDVKNLSFRYKENQNYYDVKDITFHVKRGEWLSIVGHNGS
                     GKSTTVRLIDGLLEAESGEIVIDGQRLTEENVWNIRRQIGMVFQNPDNQFVGATVEDD
                     VAFGLENQGLSRQEMKKRVEEALALVGMLDFKKREPARLSGGQKQRVAIAGVVALRPA
                     ILILDEATSMLDPEGRRELIGTVKGIRKDYDMTVISITHDLEEVAMSDRVLVMKKGEI
                     ESTSSPRELFSRNDLDQIGLDDPFANQLKKSLSQNGYDLPENYLTESELEDKLWELL"
     gene            7341..8180
                     /locus_tag="ACL8AS_001755"
     CDS             7341..8180
                     /locus_tag="ACL8AS_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000510406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HGS1229573.1"
                     /translation="MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGS
                     GKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEET
                     VLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGIL
                     AMEPAILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVM
                     EKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKES
                     LNG"
     gene            8173..8967
                     /locus_tag="ACL8AS_001756"
     CDS             8173..8967
                     /locus_tag="ACL8AS_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HGS1229574.1"
                     /translation="MDSMILGRYIPGDSIVHRLDPRSKLLAMMLLILIVFWANNPLTN
                     LILFIATGIFIALSGVSLSFFIQGLKSMFFLIAFTTIFQLFFISNGNVLFEFSFVRIT
                     DYALQQAGIIFCRFVLIIFFSTLLTLTTMPLSLASAVEALLAPLKRVKVPVHEIGLML
                     SMSLRFVPTLMDDTTRIMNAQKARGVDFGEGSIVQKVKAMIPILIPLFATSLKRADSL
                     AIAMEARGYQGGKGRSQYRQLKWTLKDTLTILVILVLGCCLFFLKS"
     gene            9026..9844
                     /gene="mreC"
                     /locus_tag="ACL8AS_001757"
     CDS             9026..9844
                     /gene="mreC"
                     /locus_tag="ACL8AS_001757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HGS1229575.1"
                     /translation="MNRFKKSKYVIIVFVTVLLVSALLATTYSSTIVTKLGDGISLVD
                     RVVQKPFQWFDSVKSDLAHLTRTYNENESLKKQLYQLEVKSNEVESLKTENEQLRQLL
                     DMKSKLQATKTLAADVIMRSPVSWKQELTLDAGRSKGASENMLAIANGGLIGSVSKVE
                     ENSTIVNLLTNTENADKISVKIQHGSTTIYGIIIGYDKENDVLKISQLNSNSDISAGD
                     KVTTGGLGNFNVADIPVGEVVATTHSTDYLTREVTVKLSADTHNVDVIELVGNS"
     gene            9844..10338
                     /gene="mreD"
                     /locus_tag="ACL8AS_001758"
     CDS             9844..10338
                     /gene="mreD"
                     /locus_tag="ACL8AS_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HGS1229576.1"
                     /translation="MRQLKRVGVFLLLPFFVLIDAHISQLLGSFFPHVHLASHFLFLF
                     LLFETIEVSEYLYLVYCFVIGLVYDVYFFHLIGITTLLFILLGAFLHKLNSVILLNRW
                     TRMLAMIVLTFLFEMGSYLLAFMVGLTVDSMSIFIVYSLVPTMILNFLWITVFQFIFE
                     KYYL"
     gene            10432..11610
                     /gene="pcsB"
                     /locus_tag="ACL8AS_001759"
     CDS             10432..11610
                     /gene="pcsB"
                     /locus_tag="ACL8AS_001759"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan hydrolase PcsB"
                     /protein_id="HGS1229577.1"
                     /translation="MKKKILASLLLSTVMVSQVAVLTTAHAETTDDKIAAQDNKISNL
                     TAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQ
                     SLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKA
                     ISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLL
                     EQKAVAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKV
                     RPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIA
                     CWNDGGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTYIYAD
                     "
     gene            11834..12613
                     /gene="rpsB"
                     /locus_tag="ACL8AS_001760"
     CDS             11834..12613
                     /gene="rpsB"
                     /locus_tag="ACL8AS_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HGS1229578.1"
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQ
                     QTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLT
                     NWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDV
                     MYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLA
                     DAIIEGRQGEDAVAVEAEFAASETQADSIEEIVEVVEGDNA"
     gene            12692..13732
                     /gene="tsf"
                     /locus_tag="ACL8AS_001761"
     CDS             12692..13732
                     /gene="tsf"
                     /locus_tag="ACL8AS_001761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation elongation factor Ts"
                     /protein_id="HGS1229579.1"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREK
                     GMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAE
                     GKPANNEESLALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNG
                     GRIGVISVVEGGDEALAKQLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNE
                     SRAMVNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRF
                     MLDNTKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEA
                     EVAATMAAALNN"
BASE COUNT         4325 a         2189 c         2976 g         4388 t
ORIGIN      
        1 atgaagaagg cagtctttct ggtttgatca ctatcaaaga tattgaaaaa gttattgagt
       61 ttccaaatgc ggctaaagat gagtttggtc gtcttctagt tgcaggtgca gtaggtgtta
      121 cttcagatac atttgaacgt gcagaggctc tttttgaggc aggagcggat gcgattgtta
      181 ttgatactgc acatggtcat tctgcaggtg tcttgcgtaa aattgccgag attcgtgctc
      241 atttcccaga tcggactttg attgctggaa atattgctac tgctgaaggt gcacgtgccc
      301 tttatgaagc gggtgtagac gttgttaagg ttggtattgg accaggttct atctgtacta
      361 ctcgtgtgat tgctggtgtt ggtgttccgc aagtaacagc tatctacgat gctgcagctg
      421 ttgcgcgcga atatggtaaa acgattattg ctgacggtgg gatcaagtat tctggagata
      481 ttgtaaaagc acttgctgca ggtggaaatg ctgttatgct tggatctatg tttgctggaa
      541 ctgatgaagc tccaggcgaa actgaaatct tccaaggacg taaattcaag acttaccgtg
      601 gtatgggatc aattgctgct atgaagaaag gttcaagcga ccgttatttc caaggttctg
      661 tcaatgaagc aaacaagctt gttccagaag gaattgaagg tcgtgttgct tataaaggag
      721 cggcagctga tattgttttc caaatgattg gtggtattcg ctctggtatg ggttactgtg
      781 gtgcagctaa ccttaaagaa ctacacgata atgctcaatt tattgaaatg tctggtgctg
      841 gtttgaaaga aagccatcct catgatgtgc aaattactaa tgaggcacca aattattcta
      901 tgtaaaaaac aatgaaaaga actccagtga aaacaggagt tcttttacaa tgttgtcaat
      961 ttccatttac agcagcttta ccatcctgaa tagtgaagat acttagattt tctggcagat
     1021 tttgaagatg gtctaagctt gttgttgtga taaaggtttg gattgattga gaaatcgttt
     1081 ctaataattt taactgtcta gtgttgtcaa gttcactcat cacatcgtca agcagtaata
     1141 taggagattc tgtggtaatg ctttccatta attcgatttc tgctaatttt atcgagagga
     1201 cgagactacg atgttgacct tggcttccga aactagcatc catcccattt atataaaaag
     1261 aaatgtcatc tcgatgagga ccgacaccag tattcttttt aaataaatct ctggatctac
     1321 ttttttctaa agcaattttg aaagattcgg ataagttttg tttgtcagtt atattgacag
     1381 aagattgata ggatattgac aactcttcga tctgattaga gagttcaaaa tgtttcttac
     1441 gcccaaatga ttctagtttt tttatgaaat ctaagcggtg attcattaca cgacatccat
     1501 aatcaactag ctgatcatct aacacagaaa ggaatgtttc atctattttt tgatctgatt
     1561 ttaggtaagt gtttctttgc tttaggatgt ggttataatt ggttaagtca gataagtaga
     1621 ttggcttaat ttgcccaagt tccatatcaa tgaattttcg tcgaatcgaa ggtgctcctt
     1681 taattagttg taaatcttca ggagcaaata agacaacatt catgtgtcct acataatctg
     1741 aaaggcgtgc ctgttttaag tgattaactt ttgttacacg gcctttttgt gttagttcga
     1801 tttctagggg aatggatcca gtttttttct gaacgagacc tgaaagatga agttgttcct
     1861 catcaaaatg aatgagattt ttatctgttc gagttcgatg actacgcgtt aaggctaaaa
     1921 aatagatagc ctctaacatg tttgtttttc cttgtgcatt acgtcccaaa aagacattca
     1981 atttaggatt aaagtctatt ttcgtttctt tgtaattacg aaaagtcttg agagatagat
     2041 gttgtagcca catgattatc taccagggaa tcgtggagct tgttggcttt taggtgatga
     2101 agcaggtttc gatttgtctt ttttaactcc cttattcatc tttttgacaa gtttagcgat
     2161 ccgttctttt tcaactttat cagcttggta ttcatcttgt tcttcagaag taggttgtgt
     2221 caacaagatg tcaatgttca tgtcagggat gtcaacttta tcgccaatac gaagtttttt
     2281 tccacgacga ctctctaatt ccctattaaa gtaaacagaa tgttcagaga gaaatgattt
     2341 aatagctcct ccgctatgtg taattccaag ttctttgagt agtgcttgga gggtaataaa
     2401 ttcttcaaat aatttgtatt ccataattca cctcaatctt tggtattata ccatattttc
     2461 ctaaaaatag tgagagagac agcgagaaat gtaagcgatt tttatttcaa aagtgttaca
     2521 gggaacaaga aaatttcagg ttttcgtgat ataatagaag tctgtatata aggaggtaaa
     2581 tcatggagtt agtgcatgga atttcaacac attttatcca atcaaaaaag tttaaaacaa
     2641 acaaaattac cgtgcgtttt accgctccat tatcccttga tacgattgca ggtcacatgt
     2701 tgagtgcaag tatgctagag actgctaatc agatgtaccc cacttctcaa gatttgagga
     2761 gacacttggc cagtctatac ggtacagata tgtcaaccaa ttgtttcaga agagggcaaa
     2821 gccacattat agaattgaca tttacctatg ttcgtgatga gtttttaagt aggaaaaacg
     2881 tgctaacctc tcagattttg gaacttgtaa aagaaactct tttttcaccc gtagtagttg
     2941 ataatgggtt tgatccggcc ttatttgaaa ttgagaaaaa acaattgcta gcaagtttag
     3001 cagctgatat ggatgattct ttttattttg cacataaaga attggataaa ttgttttttc
     3061 atgatgaacg tcttcaattg gaatatagtg atttacgaaa tcgtatttta gctgaaactc
     3121 cacaaagttc ttattcttgt ttccaagaat ttttagccaa tgatcgaata gatttctttt
     3181 tcctaggtga ttttaatgag gttgaaattc aaaatgtatt agaatcattt ggctttaaag
     3241 gtcgaaaagg agatgtgaag gttcagtatt gtcaacctta ttctaatatc cttcaggaag
     3301 gtatggttcg gaaaaatgtg ggacaatcta ttttggaatt aggttatcat taccgttcta
     3361 aatatggtga tgagcaacat ttacccatga ttgtaatgaa tggtttactt ggtggatttg
     3421 ctcactctaa gctctttaca aatgtccgtg aaaatgctgg attagcttat accatttcaa
     3481 gtgagcttga tttatttagt ggattcttga ggatgtatgc tggtatcaat cgagaaaatc
     3541 gtaaccaggc tcgtaaaatg atgaataatc aactgcttga tttaaaaaaa ggttatttta
     3601 cagagtttga gttaaatcag accaaggaaa tgattcgttg gtcgttgtta ctttctcaag
     3661 ataatcaatc ttcattgatt gaacgtgctt atcaaaatgc cttatttgga aaatcttcag
     3721 cagactttaa aagttggatt gcaaagcttg aacagattga caaagatgct atttgtagag
     3781 tagctaataa tgtgaaacta caagcgattt actttatgga aggaatagaa tgacaaaggt
     3841 tgtttttgaa gaaaaatact atccagctgt aaaagaaaag gtttatcgaa ctcgtttggc
     3901 caacggattg acagttgctc ttttgcctaa aaaggaattt aaagaggttt acgggagtgt
     3961 aactgtacag tttggttcga tagatacgct tgtcacagaa gttgacggag atgtaaaaca
     4021 atatcctgga ggaattgctc attttcttga acataaatta tttgagagag aagattctag
     4081 tgatttgatg tcggctttta cgagtctagg tgcagatagt aatgccttta caagctttac
     4141 aaaaacaaac tatctttttt cagcaacgga ttatttttta gaaaatttat atttacttga
     4201 tgaattggta acatcagcac actttactga agcttccatt ctgacagagc aggatattat
     4261 tcagcaagaa cgagaaatgt accaagatga tccagattcg tgtttattct tttcaacttt
     4321 agcgaatttg tatcctggta cacctttagc aactgatata gttggaagtg aggagtccat
     4381 ttcccaaatc aatctaacta atttgcaaga aaattttaca aagttttaca aacctgtaaa
     4441 catgtctctg tttttagttg gtaattttga tgtggagcga gtacaggact attttgaaag
     4501 caaagaactg aaagattcag attttcagga agtagcaaga gaaaagtggt ttttacagcc
     4561 tgtaaagcca acagatagta tgagaatgga agtatcttct cccaaactag cgattggagt
     4621 tagaggtaag cgagaagttt ctgaagcgga ttgctatcga catcatattt tattaaaatt
     4681 attgtttgca atgatgtttg gttggacttc ggatcgtttt caaaaatgtt atgaatcagg
     4741 taaaattgat gcgtccttat ctctggaagt tgaaataaca agtcgctttc attttgtcat
     4801 gttgacaatg gatacgaaag agccagttgc tttgtctcat caatttagga aggctattcg
     4861 taattttaca aaggatttag atattacaga ggaacattta gatattatca aaagagagat
     4921 gtttggcgaa tttttcagta gcatgaactc tcttgaattt attgcaacgc aatatgatgc
     4981 ttttgaaaat ggtgagacaa tttttgattt gccgaaaatt ttacaggaaa ttactttaga
     5041 ggatgtcctt gatgctggac atcatttaat agatgatggt gacatagttg attttacaat
     5101 attcccatcg tagtaaccta tcataataga cactagaaag aagggatgac aagtatgaga
     5161 aaaaaaacaa ttggagaggt tttacgatta gctagaatca atcagggatt gagtttagat
     5221 gaattgcaga aaaagacaga aatccagtta gatatgttgg aagcaatgga agcagacgat
     5281 ttcgatcaac ttccaagtcc tttttacacg cgttctttct tgaaaaaata tgcatgggct
     5341 gttgagttag atgaccaaat tgttttggat gcttatgatt ctgggagtat gattacttat
     5401 gaggaagtag atgttgatga agatgagttg acaggtcgta gacgttcaag taagaaaaag
     5461 aagaaaaaaa catcattttt acctttattt tattttatcc tttttgcttt atcgatttta
     5521 atttttgtga cttattatgt ttggaactat attcaaactc aaccagagga gccttctctt
     5581 tctaattaca gtgtggttca atcaacaagt tcaactagct ctgttcccca ctcctcaagt
     5641 agtagttctt ctagtataga atcagctata agtgtatcag gcgaaggaaa tcatgtagaa
     5701 atcgcttata agacaagtaa ggaaacagtt aaattgcaat tggcagtttc agatgttaca
     5761 agttgggtca gtgtttcaga aagcgaactt gagggcggtg taaccttatc gccaaagaag
     5821 aaaagtgcag aagcaacagt tgcaactaaa agtcctgtaa caattacgtt aggtgttgta
     5881 aaaggtgtta ctttgacagt agataatcag actgttgatt tatcgaaatt aacagctcag
     5941 actggacaaa tcactgtaac ctttactaaa aattaaggaa aaacgaatga aaaaagaaca
     6001 aattcccaat ctcttaacaa taggtcgaat tctctttata cctattttta tctttatttt
     6061 aacgatagga aattcgatag agagtcatat agttgcagct attatctttg ctgttgccag
     6121 tattaccgac tatttagatg gatatttagc tcgtaaatgg aatgtggtca gtaattttgg
     6181 taaatttgca gatcctatgg cggataagtt actagttatg tcggctttta ttatgttgat
     6241 tgagttaggt atggctccgg cttggattgt tgcagtgatt atctgtcgtg agttagctgt
     6301 gacaggatta aggcttttat tggttgaaac tggtggaaca attttagcag cagcaatgcc
     6361 tggaaaaatt aaaactttta gtcagatgtt tgctattatt ttcttgctat tacattggac
     6421 tttgcttggt caagttctac tttatgtagc cttatttttc actatctact ctggctatga
     6481 ctatttcaag ggtagtgcct atgtatttaa agggacattt ggttcgaaat gaaatcaata
     6541 attgatgtaa aaaatctttc ttttcgctat aaagaaaatc agaactacta cgatgtgaag
     6601 gatattacgt ttcacgtgaa acgtggagaa tggctttcga ttgtagggca taatggtagt
     6661 ggtaaatcaa ctacggttcg attaattgat ggcttactgg aagcagaatc cggagagatt
     6721 gtaattgatg gccaacgttt gactgaggaa aatgtttgga atatacgtcg tcaaatcggt
     6781 atggtttttc aaaatccaga caatcaattt gttggagcga ctgttgaaga tgatgttgct
     6841 tttggtttgg aaaatcaggg actttctcgt caagaaatga aaaagagagt ggaagaagct
     6901 ctggctttag ttggcatgtt ggactttaaa aagagagagc cagcgcgtct atcaggtggc
     6961 caaaagcaac gtgtggccat tgcaggtgtt gtagccctaa gaccagctat tttaatctta
     7021 gatgaagcaa cgagtatgtt ggatcctgaa gggcgtagag aacttattgg gacagtaaaa
     7081 ggaattcgaa aagactatga tatgacggtc atttctatta cccatgattt ggaagaagtc
     7141 gccatgagtg atcgcgtatt ggtcatgaaa aaaggggaaa ttgaatcaac tagtagtcca
     7201 agggagcttt tctctcgaaa tgatttagat caaattggat tagacgatcc ttttgctaat
     7261 caattaaaaa aatctttgag ccagaatggc tatgatttac ctgaaaatta tttgacagaa
     7321 agtgagctag aggataagct atgggaattg ctctagaaaa tgtgaatttt acatatcaag
     7381 aaggtactcc cttagcttca gcagctttgt cggatgtttc tttgacgatt gaagatggct
     7441 cttatacagc tttaattggg cacacaggta gtggtaaatc aactatttta caactcttaa
     7501 atggtttatt ggtgccaagt caagggagtg tgagggtttt tgatacctta atcacctcga
     7561 cttctaaaaa taaagatatt cgtcaaatta gaaaacaggt tggcttggta tttcagtttg
     7621 ctgaaaatca gatttttgaa gaaacggttt tgaaggacgt tgcttttgga ccgcaaaatt
     7681 ttggagtttc tgaagaagat gctgtgaaga ctgcgcgtga gaaactggct ctggttggaa
     7741 ttgatgaatc actttttgat cgtagtccgt ttgagctgtc agggggacaa atgagacgtg
     7801 ttgccattgc aggcatactt gccatggagc cagctatatt agtcttagat gagccaacag
     7861 ctggtctaga tcctctaggg agaaaagagt tgatgaccct gttcaaaaaa ctccaccagt
     7921 cagggatgac catcgtcttg gtaacgcatt tgatggatga tgttgctgaa tatgcaaatc
     7981 aagtctatgt aatggaaaag ggacgtttag taaagggggg caaaccaagt gatgtctttc
     8041 aagacgttgt ttttatggaa gaagttcagt tgggagtacc taaaattacg gccttttgta
     8101 aacgattggc tgatagaggc gtgtcattta aacgattacc gattaagata gaggagttca
     8161 aggagtcgct aaatggatag tatgattttg gggcgttata tcccagggga ttcgattgtt
     8221 caccgattgg atccacgtag caaattgctt gctatgatgc tactgatttt gattgtgttt
     8281 tgggctaata accccttgac gaatctgatt ctttttatag cgacagggat atttattgcc
     8341 ttgtcaggag tatctctttc attttttatt cagggcttga agtctatgtt tttcttgatt
     8401 gccttcacaa ctatttttca actatttttc atttctaatg ggaatgtttt atttgagttt
     8461 tcgtttgtga gaatcacgga ttatgctttg caacaagctg ggattatttt ttgtcgcttt
     8521 gtattgatta ttttcttttc aactttgtta accttaacaa ccatgccttt aagtttggca
     8581 tcagctgtcg aagctttatt agcaccttta aagcgtgtga aagttccagt tcatgaaatt
     8641 ggattgatgc tgtctatgag tttgcgtttt gtcccaacct tgatggatga tacgactcgg
     8701 attatgaatg cacagaaagc tcgtggagtg gattttggag aaggaagcat cgttcaaaaa
     8761 gtaaaggcga tgattcccat tttgattcct ctttttgcga caagtttaaa acgtgcagat
     8821 tccttggcta tcgctatgga agcgcgtggc tatcagggtg gaaaaggcag aagtcaatac
     8881 cgacaattga aatggactct aaaggatacg ctgaccattc ttgttattct cgtacttggt
     8941 tgttgtttat ttttcttaaa atcttagtag ctttcaggaa ttgataaaaa gttactgtaa
     9001 cagtttttga tagaaaggta gggatatgaa ccgttttaaa aaatcaaaat atgtcattat
     9061 tgtttttgtc actgttctgc ttgtgtcagc tctcttagcg acgacttatt caagtacaat
     9121 tgtgacaaaa ttaggagatg gaatctcatt ggttgataga gttgtacaaa aaccttttca
     9181 gtggtttgat tctgtcaaat cagatttggc tcatttgaca cgaacatata atgaaaatga
     9241 aagtttgaag aaacagcttt accaattaga agttaaatca aatgaggtgg aaagtttaaa
     9301 gacagaaaat gaacaactgc gccaattgct tgatatgaag tctaaattgc aagccacaaa
     9361 gactttagca gcagatgtta ttatgcgttc tccggtatct tggaagcagg agttgacctt
     9421 agatgcaggt agatcaaaag gtgcttctga gaacatgtta gctattgcaa atggtggctt
     9481 gattgggagt gtttcaaaag tagaggagaa ctctactata gtcaaccttc tgacaaatac
     9541 ggaaaatgct gataagattt ctgttaaaat tcaacatggc tctactacaa tttatggaat
     9601 tattattggc tatgacaagg aaaatgacgt tcttaaaatt agccaattaa atagtaatag
     9661 cgatattagt gcgggagata aggtgactac tggtggatta ggaaacttta acgttgctga
     9721 tattcctgtt ggtgaagtgg ttgccacaac gcatagtaca gactatttga cacgagaagt
     9781 aactgttaaa ttgagtgcag atactcataa tgtagatgtg atagaattag tggggaattc
     9841 ataatgagac agttgaagcg agttggagta tttttattgc ttcctttctt tgttctaatt
     9901 gacgcccata ttagccagct tctgggctca tttttccccc atgtacattt ggctagtcat
     9961 tttctttttc tatttctctt atttgagacg atagaagtat cagagtatct ctacctagtc
    10021 tattgttttg ttataggctt ggtttatgat gtttactttt tccatctaat agggattaca
    10081 actctcttat ttatcttatt gggagccttc cttcataaat tgaatagtgt tattttgttg
    10141 aatcgttgga caagaatgct agctatgatt gtgctgacat tcctgtttga aatgggtagt
    10201 tatcttttgg cttttatggt agggttgaca gtagatagca tgtcgatttt tatagtctat
    10261 agcttggtac cgacgatgat tttaaatttt ttatggatta ctgtttttca atttattttt
    10321 gaaaaatatt atctataaga acgacatata aatgtaacaa aggcgtaata tttattaggc
    10381 ctttttttgg tatactagta ttgtctttaa aagaaggagt atctacgtaa tatgaagaaa
    10441 aaaatcttag cgtcactttt attaagtaca gtaatggttt ctcaagtagc tgttttaaca
    10501 actgcgcatg cagaaacgac tgatgacaaa attgctgctc aagataataa aattagtaac
    10561 ttaacagcac aacaacaaga agcccaaaaa caagttgacc aaattcagga gcaagtatca
    10621 gctattcaag ctgagcagtc taacttgcaa gctgaaaatg atagattaca agcagaatct
    10681 aagaaactcg agggtgagat tacagaactt tctaaaaaca ttgtttctcg taaccaatcg
    10741 ttggaaaaac aagctcgtag tgctcaaaca aatggagccg taactagcta tatcaatacc
    10801 attgtaaact caaaatcaat tacagaagct atttcacgtg ttgctgcaat gagtgaaatc
    10861 gtatctgcaa acaacaaaat gttagaacaa caaaaggcag ataaaaaagc tatttctgaa
    10921 aaacaagtag caaataatga tgctatcaat actgtaattg ctaatcaaca aaaattggct
    10981 gatgatgctc aagcattgac tacgaaacag gcagaactaa aagctgctga attaagtctt
    11041 gctgctgaga aagcgacagc tgaaggggaa aaagcaagtc tattagagca aaaagcagta
    11101 gctgaggcag aggctcgtgc agctgcggta gcagaagcag cttataaaga aaaacgagct
    11161 agccaacaac aatcagtact tgcttcagca aacactaact taacagctca agtgcaagca
    11221 gtatctgaat ctgcagcagc acctgtccgt gcaaaagttc gtccaacata cagtacaaac
    11281 gcttcaagtt atccaattgg agaatgtaca tggggagtaa aaacattggc accttgggct
    11341 ggagactact ggggtaatgg agcacagtgg gctacaagtg cagcagcagc aggtttccgt
    11401 acaggttcaa cacctcaagt tggagcaatt gcatgttgga atgatggtgg ctatggtcac
    11461 gtagcggttg ttacagctgt tgaatcaaca acacgtatcc aagtatcaga atcaaattat
    11521 gcaggtaatc gtacaattgg aaatcaccgt ggatggttca atccaacaac aacttctgaa
    11581 ggttttgtta catatattta tgcagattaa tttacagagg gactcgaata gagccctctt
    11641 ttcaggtttt accgtgacaa tccctattaa aaattatatc aaaatagctt gaaaatattg
    11701 gaaaaatatg gtaaaatgaa aattgtcgtg tgaacgataa tactcattct tgatgaattg
    11761 tgaagcagtt gcccttgggt cgttttgcga gttgaagtca agaagaggaa aaaaacaaaa
    11821 aggagaaata ctcatggcag taatttcaat gaaacaactt cttgaggctg gtgtacactt
    11881 tggtcaccaa actcgtcgct ggaatcctaa gatggctaag tacatcttta ctgaacgtaa
    11941 cggaatccac gttatcgact tgcaacaaac tgtaaaatac gctgaccaag catacgactt
    12001 catgcgtgat gcagcagcta acgatgcagt tgtattgttc gttggtacta agaaacaagc
    12061 agctgatgca gttgctgaag aagcagtacg ttcaggtcaa tacttcatca accaccgttg
    12121 gttgggtgga actcttacaa actggggaac aatccaaaaa cgtatcgctc gtttgaaaga
    12181 aattaaacgt atggaagaag atggaacttt cgaagttctt cctaagaaag aagttgcact
    12241 tcttaacaaa caacgtgcgc gtcttgaaaa attcttgggc ggtatcgaag atatgcctcg
    12301 tatcccagat gtgatgtacg tagttgaccc acataaagag caaatcgctg ttaaagaagc
    12361 taaaaaattg ggaatcccag ttgtagcgat ggttgacacc aatactgatc cagatgatat
    12421 cgatgtaatc atcccagcta acgatgacgc tatccgtgct gttaaattga tcacagctaa
    12481 attggctgac gctattatcg aaggacgtca aggtgaggat gcagtagcag ttgaagcaga
    12541 atttgcagct tcagaaactc aagcagattc aattgaagaa atcgttgaag ttgtagaagg
    12601 tgacaacgct taatttatac aaatagtaat tacctaggag ggcggggctt agcccggctc
    12661 tcctattttc aaaaaatata ggagaattaa aatggcagaa attacagcta aacttgtaaa
    12721 agagttgcgt gaaaaatctg gtgccggtgt tatggacgct aaaaaagcgc ttgtagaaac
    12781 agacggtgac atcgaaaaag cgattgaatt gcttcgtgaa aaaggtatgg ctaaggcagc
    12841 taagaaagct gaccgtgttg ctgcagaagg tttgactggt gtttatgtta acggtaatgt
    12901 tgcagcagtt attgaagtaa atgctgaaac tgacttcgtt gcaaaaaacg ctcaattcgt
    12961 tgaattggta aatactacag ctaaagtcat tgctgaagga aaacctgcta acaatgaaga
    13021 atctcttgct ttgataatgc cttcaggtga aactcttgaa gctgcatacg tatctgcaac
    13081 agcaactatc ggagagaaaa tctcattccg tcgctttgca ttgattgaaa aaacagacgc
    13141 acaacacttt ggagcatacc aacataacgg tggacgtatc ggtgttattt cagttgttga
    13201 aggtggagac gaagcacttg ctaaacaatt gtcaatgcac atcgcagcga tgaaaccaac
    13261 agttctttct tacaaagaat tggatgagca attcgttaaa gatgagttgg cacaattgaa
    13321 tcacgttatc gaccaagaca acgaaagccg tgcaatggtt aataaaccag ctcttccaca
    13381 cttgaagtat ggatcaaaag ctcaattaac tgatgatgtt attgctcaag ctgaagctga
    13441 catcaaagct gaattggctg cagaaggcaa accagaaaaa atctgggaca aaattattcc
    13501 aggtaaaatg gatcgcttca tgcttgataa cactaaagtt gaccaagctt acacacttct
    13561 tgcacaagtt tacatcatgg atgacagcaa gacagttgaa gcataccttg aatcagttaa
    13621 cgcttcggta gttgagtttg ctcgctttga agttggtgaa ggtatcgaga aagctgcaaa
    13681 cgacttcgaa gctgaagttg cagctacaat ggcagcagcc ttgaataact aataatagaa
    13741 aggaagcaaa ttgcttcctt ttttgtatag ggcttagatt tttcctgaaa ttgtttggct
    13801 ctttgtcaac tgtagtgggt tgaaaaaaag ctaagcttga gaaaggacaa atttcgtcct
    13861 ttcttttttg atattcag
//
LOCUS       DBERMM010000046        13778 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.048, whole genome shotgun sequence.
ACCESSION   DBERMM010000046 DBERMM010000000
VERSION     DBERMM010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13778)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13778)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13778
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.048"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..317)
                     /locus_tag="ACL8AS_001762"
     CDS             complement(<1..317)
                     /locus_tag="ACL8AS_001762"
                     /inference="COORDINATES: protein motif:HMM:NF012798.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase"
                     /protein_id="HGS1229580.1"
                     /translation="MQKANTKLEKPINQPLSSHIFRHTLLSTLAEKNAIMVRVEHKNA
                     KTVNNIYTHVSKRMEQATLEVLNTISLNRKYIRSNLDKYITIAKTFVEIHLNFLINLC
                     ISY"
     gene            complement(649..756)
                     /locus_tag="ACL8AS_001763"
                     /pseudo
     CDS             complement(649..756)
                     /locus_tag="ACL8AS_001763"
                     /inference="COORDINATES: protein motif:HMM:NF012920.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="S26 family signal peptidase"
     gene            complement(866..1120)
                     /locus_tag="ACL8AS_001764"
     CDS             complement(866..1120)
                     /locus_tag="ACL8AS_001764"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HGS1229581.1"
                     /translation="MGTKIGISKNTIGNYEKRVRSTKKNTIFDLVKVFSSLIDALFSP
                     VQKDSPSDIQSIYDQRAPSRQGKVLTYAERQLYDQKNEVS"
     gene            1556..2428
                     /locus_tag="ACL8AS_001765"
     CDS             1556..2428
                     /locus_tag="ACL8AS_001765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HGS1229582.1"
                     /translation="MKKSRKLATLGICSALFLGLAACQQQHATSEGTNQRQSSSAKVP
                     WKASYTNLNNQVSTEEVKSLLSAHLDPNSVDAFFNLVNDYNTIVGSTGLSGDFTSFTH
                     TEYDVEKISHLWNQKKGDFVGTNCRINSYCLLKNSVTIPKLEKNDQLLFLDNDAIDKG
                     KVFDSQDKEEFDILFSRVPTEATTDVKVHAEKMETFFSQFQFNEKARMLSVVLHDNLD
                     GEYLFVGHVGVLVPTDDGFLFVEKLTFEEPYQAIKFASKEDCYKYLGTKYADYTGEGL
                     AKPFIMDNDKWVKL"
     gene            complement(2561..2918)
                     /locus_tag="ACL8AS_001766"
                     /pseudo
     CDS             complement(2561..2918)
                     /locus_tag="ACL8AS_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0032196 - transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            3061..3372
                     /locus_tag="ACL8AS_001767"
     CDS             3061..3372
                     /locus_tag="ACL8AS_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229583.1"
                     /translation="MELKDFTEKEQEMIKKRLTMSNISDKETTEKILALVPQDLIKRI
                     PFFVRKHATTRTIKRISIEHPELYAVAQTSGEIPEKECEELRQIITTIFEQKMNKHSI
                     K"
     gene            3376..4092
                     /locus_tag="ACL8AS_001768"
     CDS             3376..4092
                     /locus_tag="ACL8AS_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HGS1229584.1"
                     /translation="MKKYFIGGLGSNAYHSKDFLQELDSQVYFLNPYEKHLRDETELK
                     SWFKNEIVEEEFICLIGHSLGGDLARYLASEFEEVKKLILLDGGYLDLDKILPLDTEL
                     EETKNYIKSQIVLDLDVLTSKEKSEAKHWSENMEKAVRQSYHWNVEYNRYELAINYEN
                     IEAILRLRRKIQAFKREVGDTLFISPRYPNEATWREEALKELPDYFDTIFLENFGHEL
                     YTQAPKEIASLMNEWLAYFL"
     gene            complement(4221..5036)
                     /locus_tag="ACL8AS_001769"
     CDS             complement(4221..5036)
                     /locus_tag="ACL8AS_001769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family protein"
                     /protein_id="HGS1229585.1"
                     /translation="MIRFLVLAGYFELTIYLHLSGKLNQYINMHYSYLAYISMVISFI
                     LAIVQLYIWMKQVKTHSHLNSRLAKMTSISLLAIPLVIGLTFPTVSLDSQTVSAKGYH
                     FPLSEGTDLAIQTSEGTTSQYLKPDTSSYFSKSAYEKEMRTAADKYLSQDSIQVTNEN
                     YMEVMEAIYDYPDEFEGKTIQFTGFVYNDPSHANSQFLFRFGIIHCIADSGVYGLLTK
                     GNTRQYENNTWITAKGKLVNHYHKELKQNLPTLEIDSFTKVDKPENPYVYRAF"
     gene            complement(5033..5938)
                     /locus_tag="ACL8AS_001770"
     CDS             complement(5033..5938)
                     /locus_tag="ACL8AS_001770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HGS1229586.1"
                     /translation="MTAFQQLPSSVLQTGAIFLSIIIEALPFVLIGSIVSGLIEVYIT
                     PDKVYHFLPRNRWGRIFFGTFVGILFPSCECGIVPIINRFLEKKVPSYTAVPFLVTAP
                     VINPIVLFATYSAFGNSFHVALLRALGSIVVAVILGIFLGFFWQEPIQKENRLACHEH
                     DFSHLSPAKKVFQVFVQAIDEFFDTGRYLVFGCLFASVIQVYVPTRILTSISATPLFA
                     ILLLMILAFLLSLCSEADAFIGASLLSSFGLAPVLAFLVIGPMLDIKNILMMKNYLKA
                     RFISHFITIVTLVVLAYSLLIGVIL"
     gene            complement(5939..6070)
                     /locus_tag="ACL8AS_001771"
     CDS             complement(5939..6070)
                     /locus_tag="ACL8AS_001771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPJ_0845 family protein"
                     /protein_id="HGS1229587.1"
                     /translation="MAVKFTKRDDLDKMFEEFAKLPDLKQVTFPDDKEKKAKAEKKN"
     gene            6350..8479
                     /locus_tag="ACL8AS_001772"
     CDS             6350..8479
                     /locus_tag="ACL8AS_001772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003729 - mRNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Tex family protein"
                     /protein_id="HGS1229588.1"
                     /translation="MDKKYEKISQDLGVTLKQIDTVLSLTAEGATIPFIARYRKDMTG
                     SLDEVAIKAIIDLDKSLTNLNDRKEAVLAKIQEQGKLTKELEEAILVAEKLADVEELY
                     LPYKEKRRTKATIAREAGLFPLARLILQNIVDLEKEAEKFVCEGFATGKEALTGAVDI
                     LVEALSEDVTLRSMTYQEVLRHSKLTSQAKDESLDEKQVFQIYYDFSETVGTMQGYRT
                     LALNRGEKLGVLKIGFEHATDRILAFFATRFKVKNAYIDEVVQQSVKKKVLPAIERRI
                     RTELTEKAEEGAIQLFSDNLRNLLLVAPLKGRVVLGFDPAFRTGAKLAVVDATGKMLT
                     TQVIYPVKPASARQIEEAKKDLADLIGQYGVEIIAIGNGTASRESEAFVAEVLKDFPE
                     VSYVIVNESGASVYSASELARQEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIGV
                     GQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTASPALLSHVAGLNKTISENIVKYRE
                     EEGKITSRSQIKKVPRLGAKAFEQAAGFLRIPESSNILDNTGVHPENYAAVKELFKCL
                     DIKDLNEEAQSKLKSLSVKEMAQELDLGPETLKDIIADLLKPGRDFRDSFDAPVLRQD
                     VLDIKDLVVGKKLEGVVRNVVNFGAFVDIGIHEDGLIHISHMSRKFIKHPSQVVAVGD
                     LVSVWVKKIDTEREKVNLSLLAPNETD"
     gene            8466..8915
                     /locus_tag="ACL8AS_001773"
     CDS             8466..8915
                     /locus_tag="ACL8AS_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SprT family protein"
                     /protein_id="HGS1229589.1"
                     /translation="MKLTDYVKQVSLEDFGRPFIHHVQWNRRLRSTGGRFFPKDGHLD
                     FNPKVYQELGLDVFRKIVRHELCHYHLYFQGKGYQHKDRDFKELLKAVDGLRFVPSLP
                     KSNSKPIKLYRCQSCQQTYQRKRRIDTQRYRCGLCRGKLLLVNQPED"
     gene            8974..9246
                     /locus_tag="ACL8AS_001774"
     CDS             8974..9246
                     /locus_tag="ACL8AS_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HGS1229590.1"
                     /translation="MNSKFYKMRRNRMISGVLAGLSDKWNFDVTLVRFLFAIFTVANF
                     GLGVIIYIILASIMPTKEEIEAEMYGTGPRKRKEAQAIDDNEGWFW"
     gene            complement(9601..9792)
                     /locus_tag="ACL8AS_001775"
     CDS             complement(9601..9792)
                     /locus_tag="ACL8AS_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229591.1"
                     /translation="MKHKEHILIGFLYLLSPFIGQLLVEHTHFIGTEFTGTAYVICWL
                     SVVISIHHFSKNVLSQQQK"
     gene            10220..10978
                     /locus_tag="ACL8AS_001776"
     CDS             10220..10978
                     /locus_tag="ACL8AS_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229592.1"
                     /translation="MTLLDVKHVQKIYKTRFQGNQVEALKDIHFTVEKGDYVAIMGES
                     GSGKSTLLNILAMLDKPSRGQVYLNGTDTATIKNSQASSFRREKLGFVFQDFNLLDTL
                     SVKDNILLPLVLSRRPITEMMKKLVVTAENLGINQLQEKYPYEISGGQKQRVAVARAI
                     ITDPEILLADEPTGALDSKSSAALLDVFDEINERGQTILMVTHSTAAASRAKRVLFIK
                     DGILYNQIYRGEKTERQMFQEISDTLTVMASEVN"
     gene            10980..12968
                     /locus_tag="ACL8AS_001777"
     CDS             10980..12968
                     /locus_tag="ACL8AS_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229593.1"
                     /translation="MFRLTNKLAVSNLIKNRKLYYPFALAVLLAVTVTYLFYSLTFNP
                     KIAEIRGGTTIQATLGFGMFVVTLASAIIVLYANSFVMKNRSKELGIYGMLGLEKRHL
                     ISMTFKELVVFGILTVGAGIGIGALFDKLIFAFLLKLMKLKVELVATFQMNVVIAVLV
                     VFGLIFLGLMFLNALRIARMNALQLSREKASGEKRGRFLPLQTILGSISLGIGYYLAL
                     TVTDPLTALTTFFLAVLLVIFGTYLLFNAGITVFLQILKKNKKYYYQPNNLISVSNLI
                     FRMKKNAVGLATIAILSTMVLVTMSAATSIFNSAESFKKVLNPHDFGVSGQNVEKEDL
                     DKLLSQFASDKGYKIKEKEVLRYTYFAVANQEGTKLTIFEKGQNRVQPKTVFMVFDQK
                     DYENMTGQKLSLSGNEVGLFAKNDGLKGQKALTLNDHQFSVKEEFNKDFIVNHVPNKF
                     NILTTDYNYLVVPDLQAFLDQFPDSAIYNQFYGGMNVDASEEEQLKVAEEYENYLNQF
                     NAQLDTEGSYVYGSNLADASSQMSALFGGVFFIGIFLSIIFMVGTVLVIYYKQISEGY
                     EDRERFIILQKVGLDQKQIKQTINKQVLTVFFLPLLFAFIHLAFAYHMLSLILKVIGV
                     LDTTMMLIVTLSICAIFLIAYVLIFMITSRSYRKIVQM"
     gene            complement(13010..13684)
                     /locus_tag="ACL8AS_001778"
     CDS             complement(13010..13684)
                     /locus_tag="ACL8AS_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VIT family protein"
                     /protein_id="HGS1229594.1"
                     /translation="MDSNFAGRLNILRAGVLGANDGIISIAGVVIGVASATTNIWIIF
                     LSGFAAILAGAFSMAGGEYVSVSTPKDTEEAAVSREKLLLDQDRELAKKSLYAAYIQN
                     GECKTSAQLLTNKIFLKNPLKALVEEKYGIEYEEFTNPWHAAISSFVAFFLRSLPPML
                     SVTIFPSEYRIPATVLIVGVTLLLTGYTSARLGKDPTRTAMIRNLAIGLLTMGVTFLL
                     EQLFSI"
     gene            complement(13626..>13778)
                     /locus_tag="ACL8AS_001779"
     CDS             complement(13626..>13778)
                     /locus_tag="ACL8AS_001779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HGS1229595.1"
                     /translation="YPKKCLDYKSPREDFWMANLNLKFSVRNKSRNRFKFCRSFKYPA
                     RRCSWC"
BASE COUNT         4209 a         2545 c         2836 g         4188 t
ORIGIN      
        1 aaataagata tgcacaaatt gattaggaaa ttcaaatgaa tttctacaaa tgttttagca
       61 atcgtaatgt acttgtctag attcgatctg atatattttc gatttaatga tatggtattt
      121 aaaacctcca aagtagcttg ctccattctt ttacttacgt gagtgtagat gttatttact
      181 gttttagcgt ttttgtgttc cactctaacc attatagcat tcttctcagc tagtgtacta
      241 aggagtgtgt gcctgaaaat atgggaacta aggggctggt ttatcggttt ctctagttta
      301 gtatttgcct tttgcaaagt gatgttaaat gcctttctct aaatttacat atcactattg
      361 tttaacaaaa tctaatctac tttaggtcac ttattctttt tttgaaatgt agaatgaact
      421 ttttcaaagt ttttcgaatc ttttaaaatc tgtttgtttt atatcgccat tctccccctt
      481 ttttaattct ccctatatag cctgacaact ttcccgatgg tacgaatatg gttgctttcg
      541 tctaggtgga tgtcggggta tttgggattg agttttttta aggtagcctt ggcggagttt
      601 cttgacatag ttagcgccgt ctacttggaa gatgccgatg gtattatagt caatctgtgg
      661 ggtattcttg ataaataggt agtcgctgtt tcttatcttt ggctccatgg acttgctgat
      721 gacataagcg attgggtcgt agtcgtctgg gataatggaa actccatatc taaatcgttg
      781 tcctgcatcg agcggctacc tgcagagata aactatctaa cacgagagta agtagtctgt
      841 ctgtagtcgt ccagtctgat gatttttacg atacttcgtt tttctgatca tacagttgcc
      901 tctcggcata ggtcagaact ttaccttgtc tggatggtgc ccgttggtcg tagatagatt
      961 ggatatcgct aggagaatcc ttttgaactg gagaaaagag ggcatcaatc aagctactga
     1021 atactttaac taagtcaaat atagtatttt tcttagtaga cctaaccctt ttttcataat
     1081 ttccaatggt gtttttactt ataccaatct tagtacccaa ttcttattga gttcaaccat
     1141 tactagtcta tattgtttta tagttgattg agtttggaat agtacgctgt agctgctaaa
     1201 acatttctag gaattaattt gcctttccta atagagttgt tcatatctta tttcaatcta
     1261 ctatattttt cgcctctaac aatcgcaatc tcttctttat ctacgaacga aatcgctttc
     1321 tatttttgta agtaaagcat cacacgaaat ccacgaaaat gaaaaccttt gttgtgtttt
     1381 cgtaaaaaat ttgttgacag agcacgaaac gcctactata attaaatcaa gcttaaggaa
     1441 ataacaaaaa aacaaatcgg agggaaagac gatgaacaca ttaaatgaga aagtaatcaa
     1501 tatctgtaaa gcaatagtta aagaaacttt aatccaagac atttaggaga aagaaatgaa
     1561 gaaatcaaga aaattagcca cattaggaat ctgttcagct ttgtttttag gcttggctgc
     1621 ttgtcaacaa caacatgcta cttctgaggg gacgaatcaa aggcaaagca gttcagcgaa
     1681 agttccatgg aaagcttcat acaccaacct aaacaaccag gtaagtacag aagaggtcaa
     1741 atctctctta tcagctcact tggatccaaa tagtgttgat gcatttttta atctcgttaa
     1801 tgactataat actattgtcg gctcaactgg cttatcagga gatttcactt cctttactca
     1861 caccgaatac gatgttgaga aaatcagtca tctctggaat caaaagaagg gcgatttcgt
     1921 tgggaccaac tgccgtatca atagttattg tcttttgaaa aattcagtca ccattccaaa
     1981 gcttgaaaag aatgaccagt tgcttttcct agataatgat gcgattgata aaggaaaggt
     2041 ctttgattca caagataagg aagagtttga tattctattt tcgagagttc caactgaggc
     2101 aactacagat gtcaaggttc acgctgaaaa gatggaaaca ttcttctcac aatttcaatt
     2161 caatgaaaaa gctcgaatgc tgtctgtagt cttgcacgac aatctggatg gcgagtatct
     2221 gtttgtaggc cacgttgggg tcttagtacc tactgatgac ggtttcttat ttgtagagaa
     2281 attgactttc gaagagccct accaagcgat taaatttgct agtaaggaag attgctacaa
     2341 gtatttaggc accaagtatg cggattatac aggcgaggga ctggctaagc cttttatcat
     2401 ggataatgat aagtgggtta aactttaata gtgttatgat atgacagtaa tcttaggatt
     2461 tttatttcta tttttgatga gttggtgggt tatttcaatc gttaatagcc agaaaccacg
     2521 caaaaatgaa acatttattg gctatatcca aagatacgat attgatggga atggctatca
     2581 atcattaccg tgtcctcaga actgagagga gttcttgaaa tcgtaaaact actttgaaca
     2641 agagttactt caacccattg gatccgacgg agtaagttgc tttcgtggat accaaaaaca
     2701 gccgcaattt cttcataagt gcggtattct cgcacatatt gaagagtggc cataagaagg
     2761 tcttctaggc ttaatttagg ttttcgtccc ccttttgtgt gtttaagttg ataagcagtt
     2821 tttaatacag ctaatatctc ttcaaaagtg gtgcgctgaa caccaacaag acatttaaat
     2881 cgtgcatcag ttagttgttt acttgcttca taattcatag aactactata ccatattttg
     2941 tttcgcagga agtctaatgc taaaatctta tcagtgagaa gatttcttaa agtttattct
     3001 ttgtaatttc atctgtatta gtacataatt taacttagag aaaataggag gactaatcga
     3061 atggaattaa aagattttac agaaaaagaa caggaaatga ttaagaaaag gcttacaatg
     3121 tctaatatta gtgacaaaga aactactgag aagattctgg cgctagtacc acaagacttg
     3181 attaagcgaa tcccgttttt tgtcagaaaa catgctacaa cacgtacgat taaacgcatt
     3241 tcaattgaac accctgaact ctacgctgta gctcaaacaa gtggtgagat tccagaaaaa
     3301 gaatgcgaag aattgcgtca gattatcaca actatctttg aacaaaagat gaataagcat
     3361 agtattaagt agagaatgaa aaaatatttt attggcggtt tgggaagcaa tgcctatcat
     3421 agcaaggatt ttcttcaaga actagattcg caggtctatt ttctaaatcc atatgaaaag
     3481 catcttcgag atgaaacaga attgaaatca tggtttaaaa atgagattgt agaggaagaa
     3541 tttatctgtc tgataggtca ttctcttgga ggagatttag ctcgttatct cgcatcggaa
     3601 tttgaagaag taaagaaact gattcttttg gatggtggct atctagattt agataagatt
     3661 ttacctttgg atacagagtt agaggaaact aaaaattata tcaaatctca aattgttttg
     3721 gacttagatg ttcttacttc taaagaaaaa tctgaagcaa agcattggtc agaaaatatg
     3781 gagaaagctg taagacagtc ctatcactgg aatgttgagt ataatagata tgagttggct
     3841 ataaattatg aaaatataga agcgatactc cgcctacgga gaaaaataca agcttttaag
     3901 agagaagtgg gagatacctt gtttattagt cctcgctatc ctaatgaagc tacatggaga
     3961 gaggaagccc taaaagaatt gccagactat tttgatacta tttttttaga aaactttggc
     4021 catgagcttt atactcaagc acctaaagaa atcgctagtc taatgaatga gtggctcgct
     4081 tattttctat gagctacttg tattgctgga aatggtataa gatgaaaatc tacaagtcac
     4141 taattttcat ataacaaaaa acgaacaggc tctttttctg ttattcagaa gagaacttgt
     4201 tcgtttttat cttgattttc ttaaaaagct ctatatacat agggattttc tggtttatcg
     4261 actttggtaa agctgtcgat ttccaaggtt ggaaggtttt gtttgagttc tttatggtag
     4321 tgattgacca gttttccttt ggctgttatc caagtgttgt tttcatactg ccgggtattg
     4381 cccttggtca gcaatccata gacaccagaa tctgcgatac agtggataat gccgaatcgg
     4441 aacagaaatt gactattggc atgactgggg tcgttataga caaagcctgt aaactggatt
     4501 gtcttgccct caaactcatc tggatagtcg tagatagcct ccatgacttc catatagttt
     4561 tcattagtga cctgaatact atcttgggat aagtatttat ccgccgccgt tcgcatttcc
     4621 ttttcatagg ctgattttga aaaataagaa ctggtatctg gtttcaaata ttggcttgtc
     4681 gtcccttcgc ttgtctgaat ggctagatcc gttccttccg atagggggaa atgataacct
     4741 ttagcagaaa cagtctgaga atccaagcta acagttggga aagttaagcc gatgacaagt
     4801 ggaatagcca gaagagaaat actcgtcatc ttggctaatc ggctgttcag atgactgtgg
     4861 gttttgactt gcttcatcca gatatacaat tgaacgatag ccaagataaa agaaatcacc
     4921 atggagatat aggccagata ggaatagtgc atgttgatgt actggtttag tttgcccgac
     4981 agatggaggt aaatagtcag ttcaaaatag ccagctaaaa ctaaaaatcg aatcatagga
     5041 tgactccaat caagagagaa taggctaaaa cgaccagagt cacaatcgta atgaagtgac
     5101 taataaatcg tgctttcaag taatttttca tcataagaat atttttgata tccagcattg
     5161 ggccaatgac gagaaaagcc agaactggag ccaaaccgaa actcgagagt agagaagccc
     5221 cgataaaggc atccgcctca ctacagagcg aaagaagaaa ggccaaaatc atcaagagca
     5281 ggatggcaaa aagaggagtc gcactgatag aggtcagaat ccgagtcgga acataaacct
     5341 gtataacaga ggcaaagaga cagccaaata ccaaataacg tcccgtatca aaaaactcat
     5401 caatggcttg cacaaagacc tgaaaaactt tttttgcagg acttaagtga gaaaaatcat
     5461 gctcatgaca ggctagacga ttttcttttt gaatcggttc ttgccagaaa aatcctagaa
     5521 aaattcctag tattacagcc acaacgatgg aacccagagc tcgtaatagg gcgacatgga
     5581 aggagttgcc aaaggcagaa taggtcgcaa aaagaacaat gggattgata acaggtgctg
     5641 tcacaagaaa aggaacggcc gtgtaacttg gaaccttttt ttccagaaaa cgattgatga
     5701 tggggacgat tccacattca caggaaggga aaagtatacc gacaaaggtc ccaaaaaaga
     5761 ttctccccca acgatttcga gggagaaaat gataaacctt gtcaggtgtg atataaactt
     5821 caatcagccc tgagacaata cttcctatca gaacgaaggg aagggcttca atgataatgg
     5881 agagaaaaat ggctccagtt tgaagtacac tagatgggag ttgttgaaaa gcagtcatct
     5941 agtttttctt ttctgctttg gcttttttct ctttgtcatc agggaaagtg acttgtttca
     6001 aatcagggag tttagcaaac tcttcaaaca tcttgtccaa gtcgtctcgt tttgtaaatt
     6061 tgacagccat aggtgtacct cgattctaaa ttctacctct attatactat tattttgcgg
     6121 aaaagggagt tttttaattt gttttcgata gttgatactc ttcgaaaatc tcttcaaacc
     6181 acgtcagctt cgccttaccg tagtacggtt actgacttcg tcagttctat ccacaacctc
     6241 aaaacagtat tttgagcagc ctacggctag cttcctagtt tgctttttga tttttattga
     6301 gtatgaaaag gattggagaa agccttccag cttgtggtat aatagattta tggataaaaa
     6361 atatgaaaaa atctctcagg atttgggagt gacgttaaag caaattgata ccgttctaag
     6421 tttgacagct gaaggggcga ctattccctt tatcgcgcgt tatcgcaagg acatgactgg
     6481 tagtctggat gaggtggcga ttaaggctat tattgatttg gataaaagtc tgacaaatct
     6541 caatgaccgt aaggaagctg tcttagctaa gattcaagaa caaggtaagt tgaccaagga
     6601 attggaagaa gctatcttag ttgccgaaaa attagcagac gttgaagaac tctatcttcc
     6661 ttataaggaa aagcgtcgta ccaaggcaac cattgcccgt gaagctggac tctttcctct
     6721 tgctcgcttg attttgcaga atatagttga cttagagaaa gaagctgaaa agttcgtctg
     6781 tgaaggattt gcgactggca aggaagcctt gaccggtgca gttgatattt tggtcgaagc
     6841 cttatcggaa gatgtgacct tgcgttctat gacttatcag gaagtgctga gacactctaa
     6901 actcacttct caagccaagg atgaaagtct tgatgaaaag caggtttttc agatttatta
     6961 tgatttttca gagacagttg gaactatgca aggctatcgt accttggctc tcaatcgtgg
     7021 ggagaaactt ggtgtcttga agatcggttt tgaacatgcg acggaccgta ttcttgcctt
     7081 ctttgctact cgtttcaagg tgaaaaatgc ttatattgat gaagttgttc agcaatccgt
     7141 taagaaaaag gtcttgcctg ctattgagcg tcgtattcgg acagaattaa ctgagaaagc
     7201 tgaagaggga gctatccaac ttttttctga caatctgcgc aatctcctct tggttgctcc
     7261 actgaaaggg cgcgtggttc ttgggtttga cccagccttt cgtacaggtg ccaagctagc
     7321 tgtcgtggat gcaacaggaa aaatgctgac aactcaggtt atttatcctg ttaaaccagc
     7381 atcagctcgt caaatcgaag aagccaagaa agatttagca gatttaattg gtcaatacgg
     7441 tgtagagatt attgccattg gaaatggaac ggccagtcgt gaaagtgaag cttttgtagc
     7501 ggaagttctg aaagatttcc ctgaagtcag ctatgttatc gttaatgaaa gtggtgcttc
     7561 tgtctattct gccagcgaac ttgctcgtca ggagtttcca gacttgaccg ttgaaaaacg
     7621 ctctgccatt tctatcgccc gtcgtttgca agatcctctt gcggaattgg tcaaaatcga
     7681 tcctaagtca attggtgtcg gtcaatacca acacgatgtc agtcagaaga aactctctga
     7741 gagtctggac tttgttgtcg atacagtggt taaccaagtt ggtgtcaatg tcaatacagc
     7801 tagcccagct cttctttcac acgtagctgg actcaataaa accatttctg aaaatatcgt
     7861 caaataccgt gaggaagagg gaaaaatcac ttcacgctcc caaatcaaga aagttcctcg
     7921 tttgggggcc aaggcttttg aacaggctgc tggtttcctc cgtatccctg aaagtagcaa
     7981 tatccttgat aatacaggag ttcatccaga aaattacgct gccgttaagg aactcttcaa
     8041 atgcttggac attaaggatc tgaatgaaga ggcccaaagc aaactcaagt cgctttcagt
     8101 caaggaaatg gcgcaagagt tagaccttgg tccagaaact cttaaagata tcattgcaga
     8161 tcttctcaaa ccaggtcgag atttccgtga ttcctttgat gctccagttc tccgtcaaga
     8221 tgtcctagat atcaaggact tagtggttgg aaaaaagcta gaaggagtgg tgcgtaacgt
     8281 tgttaatttc ggtgcttttg ttgatatcgg aattcatgag gacggtctca tccatatttc
     8341 ccatatgagt cgcaagttta tcaaacaccc tagtcaagtg gtggcagttg gagatttggt
     8401 gagcgtttgg gttaagaaaa ttgatactga acgtgaaaaa gttaatctgt ctctcctagc
     8461 tccaaatgaa actgactgat tacgtcaagc aggtttcact agaagacttc ggcagacctt
     8521 ttatccatca tgtccagtgg aataggcgtc tacgttcgac aggtgggcga tttttcccca
     8581 aagatgggca tttggatttt aatcccaagg tttatcagga actggggttg gacgttttta
     8641 ggaaaattgt ccgacatgaa ctctgtcatt atcacctcta ttttcaaggg aaaggctatc
     8701 aacacaagga tcgggatttt aaggaactgt tgaaagcagt ggatggatta cggtttgtac
     8761 catccttgcc caaaagtaac tccaagccaa tcaagcttta tcgttgccaa tcctgccagc
     8821 aaacttatca gcgcaagcga aggattgata cccaacgcta tcgctgtgga ctttgtcgag
     8881 gaaagttgct attagtaaat cagcctgagg actgatgaaa gccgagccta tccgtgatat
     8941 actatgtcta acctagcaga aagaggaaat atcatgaaca gtaagtttta taaaatgaga
     9001 cgaaatcgca tgatttcagg agttttagca ggtctgtcag acaagtggaa ctttgatgtt
     9061 acccttgtac gttttctgtt tgccattttt acagtcgcaa actttggact tggagtgatt
     9121 atctatatca tcctagcttc tatcatgcct actaaggaag aaatcgaagc agaaatgtac
     9181 ggaacaggcc cacgcaaacg caaagaagcc caagcaattg acgataatga aggctggttt
     9241 tggtgaggtt ctacagaaga tttggaataa gcaaaaagct ttaaatcaat agtctaaact
     9301 gcttgattta aagctttttt tacttttata ctcaataaaa atcaaagtgc aaactaggaa
     9361 gccagccgca ggctgtaatt tagtcggcaa tgtgaagttg atatagtttg cactttgatt
     9421 tttgaatagt attaataata tttcgccagc tttatctaca aactatagtg gattggaact
     9481 agaatagtac acctctactt ctaaaaaatt gttagaaatc gatttgactg tcctgatcga
     9541 tttgtcctgt ttttatttca ttttactata aaagcagtaa tttaaactca gttttttaat
     9601 ctatttttgc tgctgagaca atacattttt ggaaaaatgg tggatgctga taacaactga
     9661 taaccagcaa ataacataag cagtgccggt aaattctgta ccgataaagt gtgtgtgttc
     9721 aactaagagc tgaccgatga atggagagag cagatagaga aatccgatga gtatatgttc
     9781 tttatgtttc attaaagcgc accttctttc cttataggtt gaacgacttg caagtgttca
     9841 atttaatggt gtgtcatcta ggtaacctta ctaaaatgtt agttcccgct tcctcctttt
     9901 caaagtaagc cttttcgcac ttatatttta caactttaaa aataggaaat caaatcattt
     9961 tctaagtaat tttgcttata tttcccccaa tcttacaaaa atgtaagatt aaagtctctt
    10021 ttgtaaggtt aggttatggc aagcggtctt tttttgatgt aaactagact cataaagaac
    10081 aaaggagtaa catcatgaaa caaatcgtac ataagaaaac tagaaaacca agtcacaaag
    10141 aaattgagcg cgttcagctg ggatgcgcta tgatgcaagc gacatttcat tttatgggat
    10201 attaagaaag gagattctca tgacactttt agatgtaaaa cacgttcaaa aaatttataa
    10261 aacacgtttt cagggcaacc aagtagaagc cctcaaggat attcacttta ccgtagaaaa
    10321 gggtgactat gttgccatca tgggtgagtc tggttctggt aaatccactc ttctcaatat
    10381 cctagctatg ctggacaaac caagtcgtgg tcaggtttac ttaaatggaa ctgatacagc
    10441 aactattaaa aattcacaag cttctagctt ccgtcgtgaa aagttgggct ttgtcttcca
    10501 agactttaac ttgctagata ctctgtctgt taaagacaat atcttgcttc cacttgtctt
    10561 gtcaagaaga cctattacgg aaatgatgaa gaaattggtg gtgacagctg aaaatctggg
    10621 tatcaaccaa ttgcaagaga agtaccctta cgaaatttca ggtgggcaga aacagcgtgt
    10681 agcagtagcc cgcgccatca tcacagaccc tgaaattctc cttgcggacg agccaacagg
    10741 agcccttgat tccaagtcat ctgcagcctt acttgatgtc tttgatgaaa tcaatgagcg
    10801 tgggcaaacc atcctcatgg taacccactc aacagcagct gctagcaggg ccaagcgtgt
    10861 tctctttatc aaagacggca ttctttacaa ccaaatctac cgtggagaga agacagagcg
    10921 tcagatgttc caagaaatct ctgacacctt gactgtcatg gcaagcgagg tgaattagta
    10981 tgtttcgatt aaccaataag ttagcggtat cgaacttgat taaaaaccgc aaactctact
    11041 atccctttgc actggctgtt ctcttggcag tcaccgtcac ctatctcttt tactccctaa
    11101 ccttcaatcc aaagattgcg gaaatccgtg gaggaaccac cattcaagca acacttggat
    11161 ttggtatgtt tgttgttacc cttgcgtcag ccattatcgt cctctatgcc aatagttttg
    11221 tcatgaagaa ccgttccaag gaactaggaa tttatggcat gttgggcttg gagaagcgtc
    11281 atcttatcag tatgaccttt aaggagttag tggtatttgg gattctaact gttggagcgg
    11341 gtatcggtat tggagccttg tttgacaagt tgattttcgc tttcctgctc aaactaatga
    11401 aattgaaggt tgagctggtt gctaccttcc aaatgaatgt tgtcattgca gtacttgttg
    11461 tctttggatt gattttccta ggcctcatgt tcctgaatgc ccttcgaatc gcccgtatga
    11521 atgccctcca gctctcgcgt gagaaagcaa gcggagagaa aagaggtcgt ttcctacctc
    11581 tccaaacgat tcttggttcc ataagtttag ggattggcta ttatcttgcc cttacggtaa
    11641 ccgatcctct tacagcccta acaactttct tcctagctgt tttactggtt atctttggta
    11701 cttatctttt gttcaatgca gggattaccg ttttccttca aatcttaaag aaaaataaga
    11761 aatactatta ccaacctaat aatctcatat ctgtttctaa cttgattttc cgtatgaaga
    11821 aaaatgcagt tggactagca actatcgcta ttttgtcaac aatggttttg gtaaccatgt
    11881 cagcagcgac aagcattttc aattccgcag aatcctttaa aaaagttcta aatcctcatg
    11941 attttggggt ttcagggcaa aatgttgaaa aagaagattt ggacaaactc ttgagccagt
    12001 ttgcaagtga caaaggttat aagattaaag agaaagaagt gcttcgttac acttactttg
    12061 ctgttgcgaa tcaagaagga accaagttaa ctatttttga aaaaggacaa aaccgtgtcc
    12121 aaccaaaaac agttttcatg gtatttgacc aaaaagatta tgaaaatatg actggtcaaa
    12181 aactgtctct atcaggaaat gaggtcggtc tctttgccaa aaatgacgga ctgaaaggac
    12241 agaaagctct aactctaaat gatcatcaat tttctgtcaa agaagaattt aataaagatt
    12301 tcattgtcaa ccatgttcca aataagttta atatcttgac tactgattac aattaccttg
    12361 ttgttcctga tttacaagcc tttttggatc aattcccaga ttcggctatc tataatcagt
    12421 tttacggtgg tatgaatgta gatgccagcg aagaagaaca actcaaggtc gctgaggagt
    12481 atgaaaacta cctcaatcaa tttaatgctc aattagacac agaaggtagc tatgtttatg
    12541 gtagcaatct agcagatgct agttctcaga tgagtgccct ctttggtggt gtcttcttta
    12601 tcggtatttt cctatccatt atctttatgg tcggaactgt tctggtcatc tactataaac
    12661 aaatttctga aggctacgaa gaccgtgaac gctttattat cttgcagaaa gtcggtttgg
    12721 accaaaagca aatcaagcaa accatcaaca aacaggtttt aactgttttc ttccttcctt
    12781 tgctctttgc cttcatacat ctcgcctttg cctaccatat gcttagcctg attttaaaag
    12841 tgattggtgt actggatacg actatgatgt tgattgtgac cttgtctatc tgcgctatct
    12901 tcctcatcgc ctatgtgctg attttcatga ttacttcaag aagttatcgc aagattgtgc
    12961 aaatgtaaaa aagatacctc gacttcaaaa tcgaggtatt tcttgtattc taaatgctga
    13021 aaagttgttc gagcaggaag gtaactccca tggtcaagag accaatagca aggttccgaa
    13081 tcatagctgt tctagtcgga tcctttccaa gtctggcact agtgtaacca gtgagaagaa
    13141 gggtcacacc gacaataagg acagtagcag ggatgcgata ttcacttggg aatatggtca
    13201 ctgacagcat tggaggcaaa cttctaagga aaaaggcaac gaagctagaa atggcagcgt
    13261 gccaaggatt ggtaaattct tcatactcaa tcccatattt ttcctctacc agagccttga
    13321 gtggattttt aagaaagatc ttattggtca agagttgggc agaagttttg cattctccat
    13381 tttggatata agcagcatag agggattttt tggctagttc cctatcttgg tctaacaaga
    13441 gtttttctcg cgaaacggca gcttcctcgg tatcttttgg agttgaaacg gatacatatt
    13501 ctccaccagc cattgaaaag gcaccagcta agatagccgc aaatcctgat aaaaagataa
    13561 tccagatatt ggtcgtggca ctggcaaccc cgataaccac accagcaatg gaaataattc
    13621 catcgttagc accaagaaca cctgcgcgca ggatatttaa acgacctgca aaatttgaat
    13681 cgatttcgtg atttgtttct gacgctaaat ttcaagttca agttagccat ccagaagtct
    13741 tctctgggtg acttgtagtc caagcatttt ttaggata
//
LOCUS       DBERMM010000047        13636 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.049, whole genome shotgun sequence.
ACCESSION   DBERMM010000047 DBERMM010000000
VERSION     DBERMM010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13636)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13636)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13636
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.049"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            1..1169
                     /locus_tag="ACL8AS_001780"
                     /pseudo
     CDS             1..1169
                     /locus_tag="ACL8AS_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632353.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
     gene            complement(1253..2455)
                     /gene="rpsA"
                     /locus_tag="ACL8AS_001781"
     CDS             complement(1253..2455)
                     /gene="rpsA"
                     /locus_tag="ACL8AS_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S1"
                     /protein_id="HGS1229596.1"
                     /translation="MNEFEDLLNSVSQVETGDVVSAEVLTVDATQANVAISGTGVEGV
                     LTLRELTNDRDADINDFVKVGEVLDVLVLRQVVGKDTDTVTYLVSKKRLEARKAWDKL
                     VGREEEVVTVKGTRAVKGGLSVEFEGVRGFIPASMLDTRFVRNAERFVGQEFDTKIKE
                     VNAKENRFILSRREVVEAATAAARAEVFGKLAVGDVVTGKVARITSFGAFIDLGGVDG
                     LVHLTELSHERNVSPKSVVTVGEEIEVKILDLNEEEGRVSLSLKATVPGPWDGVEQKL
                     AKGDVVEGTVKRLTDFGAFVEVLPGIDGLVHVSQISHKRIENPKEALKVGQEVQVKVL
                     EVNADAERVSLSIKALEERPAQEEGQKEEKRAARPRRPRRQEKRDFELPETQTGFSMA
                     DLFGDIEL"
     gene            complement(2617..2688)
                     /locus_tag="ACL8AS_001782"
     tRNA            complement(2617..2688)
                     /locus_tag="ACL8AS_001782"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2654..2656),aa:Gln,seq:ttg)
     gene            complement(2698..2778)
                     /locus_tag="ACL8AS_001783"
     tRNA            complement(2698..2778)
                     /locus_tag="ACL8AS_001783"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2742..2744),aa:Tyr,seq:gta)
     gene            complement(2828..3058)
                     /locus_tag="ACL8AS_001784"
     CDS             complement(2828..3058)
                     /locus_tag="ACL8AS_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000037109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2969 domain-containing protein"
                     /protein_id="HGS1229597.1"
                     /translation="MSKKDKKIEIQVADAKVNVGKDSFEGYTLTIGKKVIGEIAELDG
                     QFAIIKNGNVDSFYKKLEKAVEILIENYNLAK"
     gene            complement(3226..3870)
                     /gene="pcp"
                     /locus_tag="ACL8AS_001785"
     CDS             complement(3226..3870)
                     /gene="pcp"
                     /locus_tag="ACL8AS_001785"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA];
                     GO_function: GO:0016920 - pyroglutamyl-peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HGS1229598.1"
                     /translation="MKILVTGFNPFGGEKINPALEAVKLLPSEINGAEVRWVEIPTVF
                     YKSSEVLEAEILRYQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPI
                     RIDGASAYFSSLPIKAMVQAIKKQGLPAVVSNSAGTFVCNHLMYQALYLVDKKFPNMR
                     AGFMHIPYMMEQVVNKPNTAGMSLCDIVRGIEVAIEAIVDYKDKDLQLVGGETH"
     gene            complement(3885..4808)
                     /locus_tag="ACL8AS_001786"
     CDS             complement(3885..4808)
                     /locus_tag="ACL8AS_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0859 family membrane protein"
                     /protein_id="HGS1229599.1"
                     /translation="MTELAKQLLELTYIVIGCQFLHTAYCSYKDKTNPVRLGTSAFWT
                     LLSITFIGGSYMPNMSIGIIVILLSLLTLFKQVRIGTLPSLDEMKANIESNRLKNKIF
                     IPVMLMAILALVLAQMIPEFSKISISLAALFATISVLVITNSHPKSLLSENNRMTQQV
                     STSGIVPQLLGALGAIFTVAGVGDVISHLISGIVPSDSRFIGVLAYVLGMVLFTMIMG
                     NAFAAFTVITAGVGVPFVFALGANPIVAGALAMTAGYCGTLLTPMAANFNALPAALMD
                     MKDQNGVIKAQAGVALVMIVIHIFLMYFLAF"
     gene            complement(4805..5494)
                     /locus_tag="ACL8AS_001787"
     CDS             complement(4805..5494)
                     /locus_tag="ACL8AS_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0858 family membrane protein"
                     /protein_id="HGS1229600.1"
                     /translation="MEWIRLIGIAIIVVGFILKFDTIATVVLAGLVTALVSGVSLVEF
                     LEILGKEFSNQRVLTIFMVTLPLVGLSETFGLKQRSIDLIRKIKGLTVGNFYTVYFFI
                     RELAGFFSIRLGGHPQFVRPLVQPMGEAAAESQLGRKLTEVEDETIKARAAANENFGN
                     FFAQNTFVGAGGVLLIGGTLDQLGYESNYAGIASTSIIVAVITLIVVGIYNYLFDKKL
                     ISKKTRGGEQK"
     gene            complement(5559..6263)
                     /locus_tag="ACL8AS_001788"
     CDS             complement(5559..6263)
                     /locus_tag="ACL8AS_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1229601.1"
                     /translation="MVLSTLAILVACGKTDKEADAPTTFSYVYAVDPASLGYSIATRT
                     STTDVIGNVIDGLMENDKYGNVAPSQKDYDLNSTGWAPSYQDPASYLNIMDPKSGSAM
                     KHLGITKGKDKDVVAKPGLDKYKKLLEDAVSETTDLEKRYEKYAKAQAWSTDSSLLMP
                     TASSGGSPVVSNVVPFSKPYSQVGIKGEPYIFKGMKLQKDIVTTKEYNEVFKKWQKEK
                     LESNSKYQKELEKYIK"
     gene            complement(6319..7341)
                     /locus_tag="ACL8AS_001789"
     CDS             complement(6319..7341)
                     /locus_tag="ACL8AS_001789"
                     /EC_number="2.6.1.42"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004084 - branched-chain-amino-acid
                     transaminase activity [Evidence IEA];
                     GO_process: GO:0009081 - branched-chain amino acid
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="HGS1229602.1"
                     /translation="MTVTIDWENLGFSYMKLPYRYLAHFKNGQWDQGELTEDATLHIS
                     ESSPSLHYGQQAFEGLKAYRTKDGSVQLFRPDENAKRLQRTCDRLLMPQVPTDMFVEA
                     CKAVVRANEEYVPPYGTGGTLYLRPLLIGVGDIIGVKPAEEYIFTIFAMPVGNYFKGG
                     LVPTNFLIQDEYDRAAPNGTGAAKVGGNYAASLLPGKMAKSRHFSDVIYLDPSTHTKI
                     EEVGSANFFGITADNEFVTPLSPSILPSITKYSLLYLAEHRLGLTPIEGDVPIDNLDR
                     FVEAGACGTAAVISPIGGIQHGDDFHVFYSETEVGPVTRKLYNELTGIQFGDIEAPEG
                     WIVKVD"
     gene            complement(7473..9944)
                     /gene="parC"
                     /locus_tag="ACL8AS_001790"
     CDS             complement(7473..9944)
                     /gene="parC"
                     /locus_tag="ACL8AS_001790"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005694 - chromosome [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit A"
                     /protein_id="HGS1229603.1"
                     /translation="MSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
                     LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDFSIYDAMVRMSQNWKNREILVEMH
                     GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFP
                     NLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAI
                     IQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVR
                     VNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDN
                     FTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALI
                     RASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLA
                     AIIGDERTMYNLMKKELREVKKKFATPRLSSLEDTAKAIEIDTASLIAEEDTYVSVTK
                     AGYIKRTSPRSFAASTLEEIGKRDDDRLIFVQSAKTTQHLLMFTSLGNVIYRPIHELA
                     DIRWKDIGEHLSQTITNFETNEAILYVEVLDQFDDATTYFAATRLGQIKRVERKEFTP
                     WRTYRSKSVKYAKLKDDTDQIVAVAPIKLDDVVLVSQNGYALRFNIEEVPVVGAKAAG
                     VKAMNLKEDDVLQSGFICNTSSFYLLTQRGSLKRVSIEEILATSRAKRGLQVLRELKN
                     KPHRVFLAGAVAEQGFVGDFFSTEVDVNDQTLLVQSNKGTIYESRLQDLNLSERTSNG
                     SFISDTISDEEVFDAYLQEVVTEDK"
     gene            complement(10145..10349)
                     /locus_tag="ACL8AS_001791"
                     /pseudo
     CDS             complement(10145..10349)
                     /locus_tag="ACL8AS_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014166.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
     gene            complement(10364..12307)
                     /gene="parE"
                     /locus_tag="ACL8AS_001792"
     CDS             complement(10364..12307)
                     /gene="parE"
                     /locus_tag="ACL8AS_001792"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005694 - chromosome [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="HGS1229604.1"
                     /translation="MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHL
                     VWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTIL
                     HAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVMTLK
                     KVGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDE
                     AIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVN
                     NVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPE
                     EHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAA
                     RKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQ
                     AILPLRGKVVNTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDAD
                     TDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEE
                     LRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGD
                     KVEPRRKWIEDNVKFTLEEATVF"
     gene            12443..13084
                     /gene="plsY"
                     /locus_tag="ACL8AS_001793"
     CDS             12443..13084
                     /gene="plsY"
                     /locus_tag="ACL8AS_001793"
                     /EC_number="2.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0008374 - O-acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006654 - phosphatidic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HGS1229605.1"
                     /translation="MITIVLLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNT
                     FRILGKKAGMATFVIDFFKGTLATLLPIIFHLQGVSPLIFGLLAVIGHTFPIFAGFKG
                     GKAVATSAGVIFGFAPIFCLYLAIIFFGALYLGSMISLSSVTASIAAVIGVLLFPLFG
                     FILSNYDSLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK"
     gene            complement(13127..13636)
                     /locus_tag="ACL8AS_001794"
                     /pseudo
     CDS             complement(13127..13636)
                     /locus_tag="ACL8AS_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT         3937 a         3062 c         2400 g         4237 t
ORIGIN      
        1 gaagaaatat gactttcaaa aaccgtctaa gatcccttac ctcgaaacaa ctggtatgcc
       61 ttctagaatt ctccttagaa aacgccgttt caagtgctat cactgttcaa aaatgatggt
      121 cgctgaaact tctatcgtca agaagaatca tcaaattcct cgtattatca accaaaaaat
      181 tgcgcaaaag ttgattgaga agatttctat gaccgatatt tctcatcagc tggccatttc
      241 aacttcaact gtcattcgca agctcaatga ttctcacttt gagcatgatt tttcgcgtct
      301 tcctgagatt atgtcctggg acgttgaaac agtccgggga gtgactgttt caatcgggag
      361 atggagatga gctttattgc gcaagatttt aacaatctca atatcatcac tgttcttgag
      421 ggtagaacac aagctatcat tcgaaatcac tttcttcgct acgatagagt tgtccgatgt
      481 cgcgtcaaaa ttattactat ggatatgttt agtccttact atgatttggc taaacagctt
      541 cgctttcaaa tttctaggct caggctgaaa cagtctccca gactgtttca ctcccgaatg
      601 ctaaaatcgt tcttgatcgc tttcacattg tacaacatct tagccgtgct atgagtcgtg
      661 tgcgtgtcca aatcatgaat caattggatc gaaaatccca tgaatacaag gctatcaagc
      721 gctactggaa actcattcaa caggatagcc gtaaactgag tgataagcga ttttatcgtc
      781 ctacttttcg tatgcactta accaataaag agattttaga caagcttttg agctattcac
      841 aaaacttgaa acaccactat cagctcttgc tttttcactt ccagaataag gaaccagaga
      901 aacttttcgg acttattgag gacaatctga agcaagttca tcctattttt cagactgtct
      961 ttaaaacctt cttcaaagat aaggaaaaga ttatcaacgc ccttcaacta cactattcta
     1021 atgccaaact ggaagcgacc aataatctca tcaaacttat caagcgcaat gcctttggtt
     1081 ttcgaaactt tgaaaatttc aaaaaacgga tttttatcgc tttgaacatc aaaaaagaaa
     1141 ggacgaaatt tgtcctttct cgagcttagc ttttttcaac ccactacagt tgacaaagag
     1201 ccgaaaaatc ccttgtttag taaacaaagg attttgtgaa ttttcaattt gattaaagtt
     1261 cgatatcacc aaacaaatca gccattgaaa atcctgtttg tgtttctgga agttcgaaat
     1321 cacgcttttc ttgacgtctt ggacgacgtg gacgagcagc acgtttttct tctttttgtc
     1381 cttcttcttg ggctggacgt tcttcaagag ctttaataga aagtgatacg cgttctgcat
     1441 ctgcgttaac ttcaagaact ttaacttgaa cttcttgacc aactttaaga gcttcttttg
     1501 gattttcaat ccgtttgtgt gaaatttgtg atacgtgaac aagtccatcg atacctggca
     1561 atacttcaac aaatgcaccg aagtcagtca aacgtttaac tgttccttct actacatcac
     1621 ctttagccaa tttttgctca acgccatccc atggtcctgg tactgttgct ttaagtgaaa
     1681 gtgatacacg tccttcttct tcgttaagat caaggatttt cacttcaatt tcttcaccaa
     1741 cagttacaac tgattttggt gatacgttac gttcatgtga caattcagtc aagtgaacca
     1801 atccgtcaac accaccaagg tcgatgaaag cgccgaagct tgtgatacga gcaactttac
     1861 cagttacaac atcaccaaca gccaatttac cgaatacttc agcgcgagct gctgcagtag
     1921 ctgcttcaac aacttcacga cgtgaaagga tgaagcggtt ttctttagcg ttaacttctt
     1981 tgattttagt atcaaattct tgacctacaa aacgctcagc gttacgtacg aaacgagtat
     2041 ccaacattga agctgggata aatccacgaa caccttcaaa ttctactgaa agtccacctt
     2101 taacggcacg cgttccttta acagtaacaa cttcttcttc gcgaccaaca agtttgtccc
     2161 atgctttgcg agcttcaagg cgttttttag atacaaggta tgtaactgta tcagtatctt
     2221 taccaactac ttgacgaagt acaagaacat ccaatacttc tcctacttta acaaagtcat
     2281 tgatatctgc atcacgatcg tttgtcaatt cgcgaagagt caagacacct tcaacaccag
     2341 ttccagagat tgcaacgtta gcttgagtcg catcaactgt caatacttca gcactaacaa
     2401 catcaccagt ctcaacttga ctaacgctat ttagcaaatc ttcaaattcg ttcatctaaa
     2461 aaatcctcca acaatcaagt ttttcttaaa cttgacatac ttataatttt tttcctaagc
     2521 acccgcaagg acatgttcat atcattcacg tctttcaatt ataaaaataa aataccctaa
     2581 gatattttgc tttttatctt gattattacc taagaactgg ggtagctgga ttcgaaccaa
     2641 cgcatgaggg agtcaaagtc ccttgcctta ccgcttggct ataccccatt aatgaaatgg
     2701 agagagaggg attcgaaccc ccgaacccga aggagcggat ttacagtccg ccgcgtttag
     2761 cctcttcgct atctctccta caatcaacat ggactattat atcatgaaaa tttcaaaaaa
     2821 acaagactta ttttgctaaa ttataatttt caatcaaaat ttccacagct ttttccaatt
     2881 ttttataaaa actatcgaca ttcccattct ttataatggc aaattgtccg tctaattcgg
     2941 caatttctcc gataactttt ttaccgatag tcaatgtata accttcaaaa ctgtctttac
     3001 caacattaac tttggcatcc gctacttgaa tttcgatttt tttatctttc ttgctcattt
     3061 catacctctc ttcacttttt ctattttaca agaaaatcct aaaactagca agaaaaaact
     3121 ctatatcagg cttctctgat atagagcttt atgtaaacaa cctcaattga tttagcatag
     3181 ttaatagtta gtaaacaagc ataattgact atccttttta ggttatcagt gagtctcacc
     3241 gcctactaac tgcaaatcct tatctttgta gtctacaata gcttcaatag ctacctctat
     3301 gcctcttaca atgtcacata gactcattcc tgcagtattc ggcttattta ctacttgttc
     3361 catcatatat ggaatatgca tgaaacctgc tctcatatta gggaattttt tatccactaa
     3421 ataaagagct tggtacatca aatgattgca aacaaaggtt cctgcactat tggatacaac
     3481 tgccggaagt ccctgttttt tgatagcttg taccatcgct ttgataggta aactactaaa
     3541 ataggccgat gctccatcaa tacgaatcgg tgtatcaatt ggttgattgc cttcgttatc
     3601 aggtatgcga gcatcatctt gattaatagc cactcgttca ggtgttaagc cggtcctgcc
     3661 gcctgcttgt ccaatacaaa gtacagcatc tggttgatat cgtaatattt ctgcctctaa
     3721 aacttctgac gacttataaa aaaccgttgg aatttctacc cagcgaactt cagccccatt
     3781 aatctcagat ggtaataatt ttacagcctc caaagctgga ttaatctttt cacctccaaa
     3841 aggattaaaa cctgtaacca atattttcat tttattttcc tttactaaaa tgcgagaaag
     3901 tacattaaga atatgtgaat aacaatcatt actagagcaa cacctgcttg agcctttata
     3961 acgccattct gatctttcat atccatcaat gctgctggta gagcgttaaa attagcagcc
     4021 attggggtca ataaggtccc acaataacct gctgtcatgg caagagcacc agccacaatt
     4081 ggattagctc ccagagcaaa tacaaaggga actccaacac ctgctgtaat aacggtgaat
     4141 gctgcaaaag catttcccat aatcattgtg aatagaacca ttccaagaac ataggccaaa
     4201 actcctataa agcgactatc tgaaggaaca ataccgctaa tcagatgaga aataacatca
     4261 ccaacacctg ctacagtaaa aatagccccc aaagccccta ataattgagg aacaatccca
     4321 cttgttgaaa cttgctgagt cattcgatta ttttctgata acagactctt agggtgacta
     4381 ttggtaatca caagaacaga aattgtagca aacaaggcgg caaggctaat cgaaatcttg
     4441 ctaaattctg gaatcatttg cgctaagacc aacgcaagta ttgccatcag cataactgga
     4501 ataaaaattt tatttttcaa cctgttagat tcaatattgg ctttcatttc atctaaggat
     4561 ggcaaggttc cgatacggac ttgcttaaac aatgttaaca gcgataatag gattacaata
     4621 ataccaatac tcatatttgg catataggaa ccacctataa acgtaataga caatagagtc
     4681 caaaatgcag atgtcccaag tcgaactggg tttgttttat ctttataact acaataggct
     4741 gtatggagaa attgacaacc aatcacaata taggtcaact ctaatagttg ctttgccaac
     4801 tctgtcattt ttgttctcct cccctagtct tttttgatat caatttttta tcaaataaat
     4861 aattgtaaat ccccactaca ataagtgtta taacagcaac aataatagat gtagaagcaa
     4921 tccctgcata attgctttca tagcctaact gatctaatgt tccccctatc aagaggactc
     4981 ccccagcacc tacaaacgta ttttgagcaa agaaatttcc aaaattttca ttcgcagccg
     5041 cacgcgcttt tattgtctca tcttcaacct ctgttaactt tctacctaat tgagactctg
     5101 cagctgcttc tcccataggt tgaaccaaag gtctgacaaa ctgagggtgt cctcctagac
     5161 gaattgaaaa gaaaccagct aactctcgaa taaagaaata aactgtatag aagtttccaa
     5221 ctgtcagacc tttaatcttt cgaatcaaat cgattgatcg ttgcttgagt ccaaaggttt
     5281 ctgacagccc cacaagaggc aaggtaacca taaaaatcgt gagcactcgc tgattgctaa
     5341 attcttttcc caaaatctcc aaaaattcaa cgagagaaac acctgaaact aaagctgtaa
     5401 ccaaaccagc taagactact gttgcaattg tatcaaattt taaaataaaa cccacaacaa
     5461 tgattgctat tcctattaat ctaatccact ccatatcaaa ctcctttata ttcaaaatga
     5521 cagtatttta aaaattttat caagatcaat accattcctt atttaatgta tttttctagt
     5581 tctttttggt atttgctatt ggattccaat ttttcttttt gccatttttt aaaaacctcg
     5641 ttatattctt ttgttgtaac aatatctttt tgcaatttca ttcctttaaa gatatatggt
     5701 tcccccttaa taccaacttg tgagtatggt tttgagaatg gtactacgtt acttacaact
     5761 ggagaaccac cagatgaagc tgttggcatc aataatgaac tatctgtcga ccaagcttga
     5821 gctttggcat atttttcata tctcttctct aggtcagtgg tctcagaaac agcatcttct
     5881 aacaatttct tatatttatc caaaccaggt ttagctacaa catccttatc ttttcctttc
     5941 gtaataccaa ggtgtttcat ggcagaacca gattttggat ccataatatt caagtaagac
     6001 gctggatctt gatagcttgg agcccatcct gtactattca aatcatagtc tttttgagaa
     6061 ggagcaacat tgccgtattt atcattttcc atcaaaccat caataacatt tccaataacg
     6121 tctgtcgtcg atgttcgagt cgctatactg tagcccaatg atgctggatc tactgcatag
     6181 acataagaaa atgttgtcgg tgcatctgct tctttatcag tttttccaca agccactaaa
     6241 atagctaacg tgctcaggac cactcctgct gttaagagcc actttttcta tttcataaaa
     6301 aatctccttt ggtttatttt aatctacttt tacaatccaa ccttctggcg cttcaatatc
     6361 gccaaactga atacccgtca attcattata taatttacgc gtcacaggac ctacttctgt
     6421 ttcactatag aatacatgga aatcatcacc atgttgaata cctccaattg gagaaataac
     6481 cgctgctgta ccacaggcac ctgcctctac aaaacggtca agattatcaa ttggaacatc
     6541 accctcaata ggagttaatc ccaagcgatg ttctgccaaa taaagcaagg aatacttggt
     6601 aatagatggc aagatagatg gactcaatgg tgttacaaat tcattatcag ctgtaattcc
     6661 aaagaagtta gctgatccga cttcttcaat ctttgtatga gttgatgggt ccagatagat
     6721 aacatctgag aaatggcgtg acttggccat ttttcctggt aagagacttg cagcatagtt
     6781 tccaccaacc ttagccgcac ctgtaccatt tggtgctgca cggtcgtact catcctgaat
     6841 caagaagttg gttgggacca aaccaccttt aaagtaattt ccaactggca tagcaaagat
     6901 ggtgaaaatg tactcttctg ccggttttac cccgataata tctccgacac caatcaaaag
     6961 agggcgaaga tataaggttc cacctgttcc gtatggtggt acgtattctt cattcgcacg
     7021 gacaactgct ttacaagctt ctacaaacat gtctgtcgga acttgtggca tcaagagacg
     7081 gtcacatgta cgttgcaggc gtttagcatt ttcatcagga cggaacagtt gaacactgcc
     7141 atccttagta cgataagctt tcaaaccttc aaatgcttgt tgtccatagt gaagacttgg
     7201 agaagactct gaaatatgca aagttgcatc ctctgtaagc tctccttgat cccattgtcc
     7261 atttttgaaa tgagcaagat agcgataagg taatttcata taggaaaaac cgaggttttc
     7321 ccaatcaatc gttactgtca tattccactc cttattctaa aaacctattt cttatattct
     7381 acactatttt tctaaaatag caagtatatt ttgtaatttt cagaaaattt ctccaataaa
     7441 aaccagctct tagaactgat tcttcatttc acttatttat cttcagtaac tacttcctga
     7501 agataagcgt caaaaacttc ttcatctgaa atcgtgtcag aaatgaagct tccattgcta
     7561 gtgcgttctg acaagttcaa gtcttgcaat cggctttcat agattgttcc tttattggat
     7621 tggacaagca gagtttggtc gttcacatcc acttccgtac tgaagaaatc gccaacaaat
     7681 ccttgctctg caactgctcc tgccaagaag acacgatgcg gtttgttttt caactcacgc
     7741 aagacttgta atcctcgttt ggcacggctg gttgctagaa tttcctcaat ggaaacacgt
     7801 ttcaagcttc cacgctgggt caagaggtag aaggacgaag tattacagat aaagccagat
     7861 tggaggacat catcttcttt caaattcata gccttgacac ctgctgcctt agcaccgaca
     7921 accggaacct cttcgatatt gaaacgcagg gcataaccat tttgactaac caagacaaca
     7981 tcatctagtt taatcggagc cactgctaca atctgatctg tatcgtcttt gagcttagca
     8041 tacttgacag acttagatct ataggtccgc catggagtaa attcttttcg ctctacccgt
     8101 ttgatttgac caaggcgagt cgctgcaaag taggttgtcg catcgtcaaa ctgatccagt
     8161 acttccacat aaaggattgc ttcattcgtt tcaaagtttg tgatggtttg gctcagatgc
     8221 tctccgatgt ccttccaacg aatatctgcc aactcatgga ttggtctgta gatgacattt
     8281 ccaagacttg tgaacatcaa gaggtgctgg gttgtcttgg cagattgaac aaaaatcaaa
     8341 cggtcatcat cacgcttgcc aatttcttcc aaggtggaag ccgcaaagga acgtggactg
     8401 gtacgcttga tgtaacctgc cttggtcacg ctgacgtagg tatcttcctc agcgataaga
     8461 ctagctgtat caatctcaat tgctttcgca gtgtcttcta aagaactcaa acgaggagtt
     8521 gcaaatttct tcttgacctc acgaagttct ttcttcatga gattgtacat agtcctttca
     8581 tcaccgataa tagccgccag catagcaatc ttctcacgaa gctctgcttc ttcttcctgc
     8641 aagacaacca catcggtatt ggtcaaacgg tacagttgca aagttacgat agcctcagcc
     8701 tgttcttccg taaaatcata gctaactttg aggttttcct tggcgtccgc cttattctca
     8761 gaagcacgga taagagcaat gacttcatcc aaaatcgaaa tcacacgaat caaaccttcg
     8821 acgatatgga gacgtttctc agccttttct ttgtcaaagc gtgaacgcgc caaaatcact
     8881 tctcgacggt gagcgatgta gctagacagg attggaacaa tcccaacctg acgaggtgtg
     8941 aaattgtcaa tcgccaccat attaaagttg tagttgattt gtaggtcggt gtacttaaat
     9001 aagtagttga gaacaagctc agtattagcg tctttcttaa gttcgatagc gatacgaaga
     9061 ccatcacggt cagactcatc acgaacctca gcaatcccag ctaccttgtt attaacacga
     9121 acatcatcga ttttcttgac tagattggcc ttattgattt cataaggaat ctcagtaata
     9181 acgatttgtt ccttaccacc ttttagcttt tcaatttcag tcttggaacg aacaaccacg
     9241 cgccctttcc cagtctcata agctttcttg atttcatcac gaccctgaat aatagcccct
     9301 gtagggaagt ctggtccagg taagaattcc atgagtttat caatctttgc agttgggtgg
     9361 tcaatcatgt aaactgcagc atctatgacc tcagctaaat tatggggagg aatgtctgtg
     9421 gcataaccag ccgaaatccc agtcgaacca ttgaccaaga ggtttggaaa ggctgctggc
     9481 aagaccgttg gttctttctc cgtatcgtca aagttccatg caaaaggaac tgtctttttc
     9541 tcgatatcct gaagaaggta gcctgcaatt tcagacaaac gtgcctcagt ataacgcata
     9601 gccgcaggag gatctccgtc catagaaccg ttattaccgt gcatttcaac tagaatctca
     9661 cgatttttcc agttctgtga catacgaacc atggcatcat agatagaaaa atctccgtgt
     9721 gggtggaaat tccccatgat gttcccgact gacttggccg acttacggta gctcttgtca
     9781 aaagtattgc tatccttatt catagaataa agaatacggc gctgaaccgg cttcaaccca
     9841 tcacgaatat ctggcaaagc ccggtcttga ataatgtact tggagtagcg accaaagcgc
     9901 tctcccatga tgtcctccag ggacatgttt tgaatgttag acataagata caaagcccat
     9961 aaaataccaa gtgaaaatag aaaattcttg aagtaagcaa actcacaaga gaatttatct
    10021 ttttcacaca gtatctaggg cgtgttcaac tcctttcaaa gaatgtagag taggttttta
    10081 tgcagtaaaa gatattttac gggaattcct cccgtgttca gttacgataa gtaaccaaac
    10141 tatcctgttt gtatttttca atatgaaaat ctggttttcc aaaattagtc ttagtttgtg
    10201 tcttagccgc tcccttaagc gcctctttga gataagcact catagcagat tcttcattaa
    10261 taatcctgca attttttcaa accaagattt tcaaactgct ttttcacata gtcattcaca
    10321 tccgactcta atttccagtt tactaacata ttattttctt tcattaaaac actgtcgctt
    10381 cttctagcgt aaacttgaca ttatcttcaa tccatttacg gcgtggttct accttatctc
    10441 ccatgagaac attgacgcgg cgttcggcgc gcgctaaatc ttcaattgtg acacggatga
    10501 gggtacgtgt ttctgggttc atggttgttt cccagagctg gtccgcattc atctcaccaa
    10561 gtcctttgta tcgttggagg gtagcgcctt taccgaactg tttacggagt tcttctagtt
    10621 ctccgtccgt ccaagcgtag gccacttctt ctttcttgcc tttacctttg gacatcttgt
    10681 aaagaggtgg gagggcaata tagacatgac ctgcctcgac tagcggacgc atgtaacggt
    10741 agaaaaatgt caagagcaag gtctggatat gggcaccatc ggtatccgca tcggtcatga
    10801 taatgatctt atcatagttg gcatcttcaa tagagaagtc tgctccaaca cccgcaccaa
    10861 tggtataaat catggtattg atctcttcat ttttgaggat atccgccatc ttggccttgg
    10921 ctgtattgac aaccttacca cgaagaggta gaatagcctg gaacttgcgg tcacgacctt
    10981 gtttggcaga accaccggca gagtccccct caactagata gagttcattc ttagcaggat
    11041 tcttagattg ggctggggtc aatttcccag acaacaagcc cttatctttc ttgtttttct
    11101 tcccatttcg gctctcatca cgcgccttac gtgctgcttc acgagcatca cgggccttga
    11161 tagccttgcg gatgaggtta gaagctaatt ccccattttc cataaggaaa aaggtcaact
    11221 tatcagccac tattccatcc acaaccgggc gagctagggg gcttcctagt ttatccttgg
    11281 tctgtccttc aaactgcaag tgttcttcag gaactaagat agaaagaacg gccgctagtc
    11341 cctcacgata gtctgaacct tcaaggtttt tatctttttc cttgagaaga cctgttttac
    11401 gtgcatagtc attcatgacc ttggtaatgg cagacttgag tcctgtctcg tgcgttccac
    11461 cgtccttggt gcgaacgtta ttgacaaagg atagaatgtt atctgagaat ccgtcattgt
    11521 actggagggc tacttccact tgaaaaccat tgtcttcccc ttcaaagtaa agaactggcg
    11581 tcaagatttc cttatcttcg ttgagataag aaacaaaatc ttgtactcca ttctcatagt
    11641 ggaactcaat cgcttcatct gttcgcttgt ccgttaaaga caaggtcaca tttttcaaga
    11701 gaaaggctga ttcattaagg cgctctgaaa tggtattgta cttgaaatct gtcgtagaaa
    11761 agatagtcgc gtcaggcata aaagtaactt tggtgcctgt tttagacttg ggtgctgtac
    11821 cgactttctt caaagtcatg acaggttttc caccattttc aaaacgttgc ttgtaaactg
    11881 cgccatcacg ggtaatttca acttctaacc agctagaaag ggcgttaaca acggaagaac
    11941 ccactccgtg aagtccacct gatgtcttat agccaccttg accgaatttc cctccggcat
    12001 gaagaatggt aaagataacc tcaacagttg gaattcccat agcgtgcata cctgtcggca
    12061 tcccacgtcc atggtcttga accgttagac taccgtcttt attgatagtt acatcaatac
    12121 gatcaccaaa cccagacaag gcttcatcga ctgcattatc aacgatttcc caaactaggt
    12181 gatgaagacc agcgccatcg gtcgatccaa tatacatccc tggacgtttt cggaccgcat
    12241 ccaacccttc tagcacctga atagcatcat cattataatt gttaatattg atttcctttt
    12301 ttgacacaag gaacctccta ttcgttcatc tttactattc tacaggtttt ccaaggattt
    12361 tgcaaaattt ttctttctcc gatgtgacaa ttttagcaga gattctctgc ttttctttcc
    12421 caattcatga tataatagga gtatgattac aatagtttta ttaatcctag cctatctgct
    12481 gggttcgatt ccatctggtc tctggattgg acaagtattc tttcaaatca atctacgcga
    12541 gcatggttct ggtaacactg gaacgaccaa taccttccgc attttaggta agaaagctgg
    12601 tatggcaacc tttgtgattg actttttcaa aggaacccta gcaacgctgc ttccgattat
    12661 ttttcatcta caaggcgttt ctcctctcat ctttggactt ttggctgtta tcggccatac
    12721 cttccctata tttgcaggat ttaaaggtgg taaggctgtc gcaaccagtg ctggagtgat
    12781 tttcggattt gcgcctatct tctgtctcta ccttgcgatt atcttctttg gagctctcta
    12841 tcttggcagt atgatttcac tgtctagtgt cacagcatcg atcgcggctg ttatcggggt
    12901 tctgctcttt ccactttttg gttttatcct gagtaactat gactctctct tcatcgctat
    12961 tatcttagca cttgctagtt tgattatcat tcgtcataag gacaatatag ctcgtatcaa
    13021 aaataaaact gaaaatttgg tcccttgggg attgaaccta acccatcaag atcctaaaaa
    13081 ataaaacgcc agttctgtac tgccccccaa aagttagaca attaatttat ccaaaggatt
    13141 tagttctgta ctgcacagga ctaagtcctt ttagttttac cttaattcgt ttattgttgt
    13201 agtaatcaat atagtctaca atagcttgtt ccaattgatt aagtgattta aatgttttct
    13261 catagccata aatttcagaa tcccaaagaa ggactccatc ataccgttgt cttggctgtt
    13321 tcccttgcgt gacatggatg cttgaattcc cttactctct aagaaccgat gataagaatc
    13381 gtgttgatat tgccagcctt gatcactatg gagaatcgta ttctcgtagt acttctctgt
    13441 gaatgcctgt tccaacattg tttgtacttg ttctaagttg ggtgaagttg aaagattata
    13501 ggcgataatt tcgctgttaa agccatctaa aactggtgat aagtaaagct tttgagtact
    13561 tgctggaatg gcaaattctg tcatatctgt gtagcacttt tccattgttt tagagccttc
    13621 aaattggcct tgaatg
//
LOCUS       DBERMM010000048        12940 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.050, whole genome shotgun sequence.
ACCESSION   DBERMM010000048 DBERMM010000000
VERSION     DBERMM010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12940)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12940)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12940
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.050"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            171..1301
                     /locus_tag="ACL8AS_001795"
     CDS             171..1301
                     /locus_tag="ACL8AS_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
                     /protein_id="HGS1229606.1"
                     /translation="MLYVGIDIAKNKHDVTALNVPGKTVLKPLTFSNNKAGFELLDLS
                     LRQLNQDCLIALENTGHYAFNLLNFLHEQGYKVYTYTPLLIKEFAKSLSLRKTKTNKK
                     DAHGIALKLLSDPNREQFQHDNRQVELKILARHIHRLKKKQSDWKVQYTRCLDIIFPE
                     LDKIVGKHSEYTYQLLTRYPNPQKRLEAGFDKLIEIKRLTASKIQDILSVAPRSIGTT
                     SPAREFEIIEIIKHYKRLIDKAETCVNDLMAEFNSVITTVTGIGGRLGAVILAEIRNI
                     HAFDNPAQLQAFAGLDSSIYQSGQIDLAGRMIKRGSPHLRWALIQAAKACARFSPAFK
                     AYLKTKLEQGKHYNVAIIHLAKKLIRTLFYILKKSCHLTNKK"
     gene            complement(1500..3389)
                     /locus_tag="ACL8AS_001796"
     CDS             complement(1500..3389)
                     /locus_tag="ACL8AS_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 domain-containing protein"
                     /protein_id="HGS1229607.1"
                     /translation="MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEF
                     RQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKVQAAKNGAELADVTSEVTEEAD
                     GYTVRVYNPGQEGDIVEVDLVWNLKNLLFLYDDIAELNWQPLTDSSESIEKFEFHVRG
                     DKGAEKLFFHTGKLFREGTIEKSNLDYTIRLDNLPAKRGVELHAYWSRTDFASARDQG
                     LKGNRLEEFNKIEDSIVREKDQSKQLVTWVLPSILSISLLLSVCFYFIYRRKTTPSVK
                     YAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTFDQLIQATLLDVIDRG
                     NVSIISEGDAVGLRLVKEDGLSRFERDCLNLAFSGKKEATLSNLFADYKVSDSLYRRA
                     KVSDEKRIQARGLQLKSSFEEVLNQMQEGVRKRVSFWGLPDYYRPLTGLEKTLQVGIG
                     VLTILPLFIGFGLFLYSLDVHGYLYLPLPILGFLGLVLSVFYYWKLRLDNRDGVLNEA
                     GAEVYYLWTSFENMLREIARLDKAELESIVVWNRLLVYATLFGYADKVSHLMKVHQIQ
                     VENPDINLYVAYGWHSMFYHSSAQMSHYASVANTASTYSVSSGSGSSGGGFSGGGGGG
                     SIGAF"
     gene            3527..5092
                     /locus_tag="ACL8AS_001797"
     CDS             3527..5092
                     /locus_tag="ACL8AS_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HGS1229608.1"
                     /translation="MRKIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQD
                     DDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKEPLVVKTKWEGLVPALTSGKIDMII
                     AGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYLYD
                     LIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGF
                     KTGEEDTAIAIGLRKNDNRISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSS
                     SFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFRTAPLSENKAIYG
                     LQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYM
                     TEIVRGGILAVDKGQFEAATALGMTHNQTMCKIVLPQVVRNILPATGNEFVINIKDTS
                     VLNVISVVELYFSGNTVATQTYQYFQTFTIIAVIYFVLTFTVTRILRFIERRMDMDTY
                     TTGANQMQTEDLK"
     gene            5092..5856
                     /locus_tag="ACL8AS_001798"
     CDS             5092..5856
                     /locus_tag="ACL8AS_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HGS1229609.1"
                     /translation="MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGK
                     STFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREKLGMVFQSFNLFENLNVLENT
                     IVAQTTVLKRERTEAEEIAKENLEKVGMGERYWQARPKQLSGGQKQRVAIARALSMNP
                     DAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGV
                     IAEEGKPEDLFTNPKEDRTKEFLQRYLILNENQRAN"
     gene            complement(6055..6270)
                     /locus_tag="ACL8AS_001799"
     CDS             complement(6055..6270)
                     /locus_tag="ACL8AS_001799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229610.1"
                     /translation="MAKSNFEKVESVVGWVRDKKITGYRISKETNAREMSIIALAQGR
                     AKVKNISFETALGLIDFYEKNHEKFED"
     gene            complement(7141..8391)
                     /gene="ilvA"
                     /locus_tag="ACL8AS_001800"
     CDS             complement(7141..8391)
                     /gene="ilvA"
                     /locus_tag="ACL8AS_001800"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004794 - threonine deaminase activity
                     [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase IlvA"
                     /protein_id="HGS1229611.1"
                     /translation="MLSSKDIIKAHKVLNGVVVNTPLDYDHYLSEKYGAKIYLKKENA
                     QRVRSFKIRGAYYAISQLSKEERERGVVCASAGNHAQGVAYTCNEMKIPATIFMPITT
                     PQQKIGQVRFFGGDFVTIKLVGDTFDASAKAAQEFTVSENRTFIDPFDDAHVQAGQGT
                     VAYEILEEARKESIDFDAVLVPVGGGGLIAGVSTYIKETSPEIEVIGVEANGARSMKA
                     AFEAGGPVKLKEIDKFADGIAVQKVGQLTYEATRQHIQTLVGVDEGLISETLIDLYSK
                     QGIVAEPAGAASIASLEVLAEYIKGKTICCIISGGNNDINRMPEMEERALIYDGIKHY
                     FVVNFPQRPGALREFVNDILGPNDDITRFEYIKRASKGTGPVLIGIALADKHDYAGLI
                     RRMEGFDPAYINLNGNETLYNMLV"
     gene            complement(8441..8797)
                     /locus_tag="ACL8AS_001801"
     CDS             complement(8441..8797)
                     /locus_tag="ACL8AS_001801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HGS1229612.1"
                     /translation="MNITNLFSIKTGCDETDRQLQKLFFQLDLQLGELTDQLRKLDSN
                     FVPRSQFVDTLDLNDVEYKEILNYFIFHRNDSEESLVEWLYDWISTNRYELPKEFSIR
                     MAHKYHESVTEVFGDE"
     gene            complement(9035..9271)
                     /locus_tag="ACL8AS_001802"
     CDS             complement(9035..9271)
                     /locus_tag="ACL8AS_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229613.1"
                     /translation="MLADQNKADWSYDENAVINIYDDANFEDGRLHMTFEQFFKLAQI
                     AREEGLEIHSPFERAGATKSARYIAKWILRNKKH"
     gene            complement(9378..10400)
                     /gene="ilvC"
                     /locus_tag="ACL8AS_001803"
     CDS             complement(9378..10400)
                     /gene="ilvC"
                     /locus_tag="ACL8AS_001803"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HGS1229614.1"
                     /translation="MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDV
                     IIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPSLEAGN
                     AVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
                     AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAG
                     YAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMK
                     AVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDD
                     AFKIYN"
     gene            complement(10466..10942)
                     /gene="ilvN"
                     /locus_tag="ACL8AS_001804"
     CDS             complement(10466..10942)
                     /gene="ilvN"
                     /locus_tag="ACL8AS_001804"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002927678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1990610 - acetolactate synthase regulator
                     activity [Evidence IEA];
                     GO_process: GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase small subunit"
                     /protein_id="HGS1229615.1"
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATEDPNVS
                     RITIIIDVASHDEVEQIIKQLNRQIDVIRIRDITDKPHLEREVILVKMSAPAEKRAEI
                     LAIIQPFRATVVDVAPSSITIQMTGNAEKSEALLRVIRPYGIRNIARTGATGFTRD"
     gene            complement(10935..12635)
                     /locus_tag="ACL8AS_001805"
     CDS             complement(10935..12635)
                     /locus_tag="ACL8AS_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase large subunit"
                     /protein_id="HGS1229616.1"
                     /translation="MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIY
                     NFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPL
                     LVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRP
                     GPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAG
                     GGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTE
                     ADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQM
                     LLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDV
                     GQHQMWTAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQM
                     TNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAY
                     GIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA
                     "
BASE COUNT         3951 a         2898 c         2232 g         3859 t
ORIGIN      
        1 ttcatttcct ccaatcgctt gacgatttcc gaaaggctct aaccacagct tttgtttcaa
       61 ttggtaatga gtttgataac gcatagacgt ttgatctcgt ctaaggtaac aaggcaaaaa
      121 attcgtggat aaccaagtag acttgaaata ctatatctgg aggtactccc atgctttatg
      181 tgggcattga tatcgctaaa aataaacacg atgttacagc cttgaatgtt ccaggaaaaa
      241 ctgttcttaa accactcact ttttcaaata ataaagctgg ttttgaactc ttagatctgt
      301 ctcttcgaca gctcaaccaa gactgtctca tcgctcttga aaataccgga cattatgcct
      361 ttaatctact gaacttcctg catgaacaag gatataaagt ttacacctac actcctttgc
      421 tcatcaagga atttgccaaa tcattatcac ttcgcaagac taaaacgaat aagaaagacg
      481 ctcatggcat cgctcttaaa cttctttctg accccaatcg tgaacaattt caacacgata
      541 atcggcaagt agaactaaaa atactggcta gacatattca tcgtctcaag aaaaaacagt
      601 ctgattggaa agtacaatac actcgttgtc ttgatatcat ctttcctgag ttggataaaa
      661 tcgttggaaa gcattcagaa tatacctacc aactcttgac acgctaccct aatcctcaga
      721 aaaggcttga ggcaggattt gataagctga tagaaattaa gcgattgacc gcttctaaaa
      781 ttcaggatat cctctcagtc gcacctcgtt ctatcggaac aacatctcct gctcgtgaat
      841 tcgaaatcat cgaaatcatc aaacattaca agaggctcat tgacaaggcg gaaacatgtg
      901 tcaatgactt gatggctgag ttcaactcgg tcatcacgac ggttactggg attgggggtc
      961 gtttaggggc ggtcatttta gccgagattc gaaatattca tgcctttgat aatcctgctc
     1021 aattacaagc tttcgctgga ctggattctt ctatttatca gtcaggtcag attgatttag
     1081 ctggaagaat gatcaaacgg ggttcccctc atctgcggtg ggcactcata caagctgcca
     1141 aagcatgcgc tcgcttttca cctgctttta aggcctatct taagactaag ttagaacaag
     1201 gaaaacatta caatgtagcc atcatccacc ttgcaaaaaa acttatccga accctgtttt
     1261 atatcctaaa aaagagctgc catttgacga acaaaaagtg atgtaatttc tgaaattaac
     1321 acaggattac ctttgaaaaa atggactttt tcaagggcct tttgccgtgc tctaaaatca
     1381 tcgccaaatc atcaaattga aataagaaat agtttagata aaactattga cttttcttat
     1441 agtttgtctt tcttctatct tccattatat catacttttt cagtctatgg tagctctctt
     1501 taaaaggctc cgatactgcc gccacctccg cctccagaga agccaccgcc agaacttcca
     1561 cttccagaag atacggagta ggtacttgct gtatttgcga cactagcata atggctcatt
     1621 tgcgcgcttg aatgataaaa catactgtgc cagccataag ctacatagag attgatatct
     1681 ggattttcaa cttgaatctg atgaaccttc atcaaatgac taaccttgtc cgcatagcca
     1741 aataaggttg catagaccaa gagacgattc caaacaacaa tactttccaa ttcagcctta
     1801 tccagtcgtg caatctcacg taacatattt tcaaaactgg tccagagata gtagacctca
     1861 gctcccgctt catttagaac accatcacga ttatctagtc gaagcttcca ataatagaaa
     1921 acagacaaaa ctaaccctag aaaaccaagt attggcaaag ggaggtaaag atagccatga
     1981 acgtctaaac tgtacaagaa caaaccaaat ccgataaata ggggcaagat agtcaagaca
     2041 cctataccca cttgcaaagt cttttccaaa ccagttaaag gacgatagta atctgggagc
     2101 ccccagaagg aaactcgttt tctcactcct tcttgcatct ggttcaatac ctcttcaaaa
     2161 gaagatttga gttgaagccc tcttgcttga atccgttttt catcagaaac tttggctcta
     2221 cgataaagac tatcagatac cttgtaatcc gcaaacaaat tggaaagagt ggcttctttt
     2281 ttgcctgaaa aggctagatt tagacagtct ctctcaaatc ttgacaaacc atcttctttc
     2341 accaatctca agccaactgc atctccttct gaaataatag agacattccc acggtctatc
     2401 acatctagca aggtagcttg aataagttga tcaaaggtga attttccagc tcccttgacc
     2461 aagggactca cttcctccaa ggaggtcgag tagactgctt ctgataaaac cataggctct
     2521 aattccattg gtggttcata gagacgatga tttttggcat atttgactga aggagtggtc
     2581 tttcttctat aaataaaata gaagcagaca ctcaataaca aggagataga aagtatcgaa
     2641 gggaggaccc aagtaacgag ttgtttactc tgatcttttt ctctaacaat cgagtcttct
     2701 atcttattaa actcttctaa acgattccct ttcaagccct gatccctagc gctagcaaaa
     2761 tcggtccgag accaataggc atgcaactca actccacgct tagccggaag attgtctaaa
     2821 cggatagtat aatcaaggtt actcttttca atcgttccct ctctaaaaag tttccctgta
     2881 tggaaaaaga gtttttcagc ccccttgtct ccccttacat gaaattcaaa cttttcaata
     2941 gactctgaac tatctgtcag aggttgccaa tttaattcag cgatatcatc ataaaggaaa
     3001 agtaaatttt ttaagttcca gacgaggtca acttcaacta tgtcgccctc ctgacctgga
     3061 ttatagactc tcacagtata accatccgct tcttctgtta cttcgctagt cacatctgct
     3121 agttctgcac cgtttttcgc agcctgaacc tttggatgag ggtcaatgtc aaacccgcta
     3181 ggcatcttac cagcacgtcc aagtcccacg atttggccct taaagtcctc ctcaaactgg
     3241 taaactatct tctgtctaaa ctctgccgta ttatctgcat gaatatacaa atccccttga
     3301 taagagttta tcttgaaatc aatggcaaaa acagagagtg gaagaaggca aaacaagcct
     3361 aacaccagta agaaaaaagt ttttttcatc aactaagccc cctttttatc tttcttatca
     3421 ttatagcatc ttttcgtaag taaaggctta cttatgttga aaaattacgc atttttcgat
     3481 aaaataggag acagttattt tttaatagat cagaatagga gaaatcatga gaaaaatata
     3541 cttatctatt ttcacaagtc tcttgctgat gctaggactt gtcaatgttg ctcaagccga
     3601 tgaatattta cgcatcggga tggaagcagc atatgctccc tttaactgga cccaggatga
     3661 tgatagcaac ggagctgtca aaatcgatgg gaccaatcag tatgccaacg gatacgatgt
     3721 tcaaatcgcc aagaaaatcg ctaaggactt aggtaaagaa cctttggttg ttaaaaccaa
     3781 gtgggaaggt ctagtccctg cccttacttc tggtaagatt gacatgatta tcgcaggtat
     3841 gagtccaact gcagaacgca aacaagaaat tgccttttcg agcagttact acactagcga
     3901 accagttttg cttgtcaaaa aagattctgc ctacgcaagt gctaaatctt tggatgactt
     3961 taacggtgca aaaatcactt ctcaacaagg ggtctacctc tacgacttga ttgcacaaat
     4021 cccaggtgct aaaaaagaaa cagccatggg agacttcgct caaatgcgac aagctcttga
     4081 ggctggtgtc attgatgctt atgtttctga acgtccagaa gcactgactg ctgaagctgc
     4141 gaactctaag ttcaagatga ttcaagtaga acctggtttc aaaactgggg aagaagatac
     4201 agctatcgct atcgggcttc gtaaaaatga caatcgtatt agccaaatca atgccagcat
     4261 tgaaaccatt tcaaaagatg accaagttgc cttgatggat cgtatgatca aggaacaacc
     4321 tgccgaagct acaacaactg aagagactag cagtagtttc tttagccaag tcgctaaaat
     4381 tctttctgaa aactggcaac aactcttgcg tggtgctggt atcactcttt taatctctat
     4441 cgtcggaacc atcataggtc tcattattgg acttgccatt ggtgtcttcc gtactgctcc
     4501 tctctctgaa aacaaagcca tttatggcct tcaaaaacta gtcggctggg ttctcaatgt
     4561 ctacattgaa attttccgtg gtacgccaat gattgttcaa tcgatggtta tctactatgg
     4621 aactgcccaa gctttcggta tcaaccttga ccgtacacta gctgctatct tcatcgtttc
     4681 aatcaatacc ggtgcctaca tgactgaaat tgtccgtggt ggtatcctgg cagttgacaa
     4741 gggacaattt gaagctgcga ctgctcttgg tatgactcat aaccaaacca tgtgtaagat
     4801 tgtcctacct caggttgtcc gcaatatcct accagcaact ggtaatgaat ttgtcatcaa
     4861 tatcaaagat acatctgtat tgaacgttat ctctgttgtc gaactttatt tctcaggaaa
     4921 taccgtggca acacaaacct atcaatactt ccagacattt acaatcatcg ccgtgattta
     4981 ctttgtcctc accttcaccg taacacgtat cctacgcttt atcgagcgca gaatggacat
     5041 ggatacctac actacaggtg ctaaccaaat gcaaacggag gatttgaaat aatgacacaa
     5101 gcaatccttg aaattaaaca cctcaaaaaa tcctatggac aaaacgaagt gctaaaagac
     5161 atttctctca ctgtccacaa gggagaagtt atttctatca tcggaagctc tggaagtggg
     5221 aaatcaacct tcctacgctc cattaaccta cttgaaacgc caactgatgg acaaatcctt
     5281 tatcatggac aaaacgtcct cgaaaaaggc tatgacctca cgcaataccg tgaaaagtta
     5341 gggatggttt tccaatcctt taacctcttt gaaaatctca acgttcttga aaacacaatc
     5401 gtcgctcaga caactgtcct taaacgcgaa cgcacagaag ctgaagaaat tgccaaagaa
     5461 aacctggaaa aggtcggcat gggagaacgc tactggcaag cgagacccaa acaactctca
     5521 ggtggtcaaa aacaacgtgt ggccatcgct cgtgcccttt caatgaatcc tgacgccatt
     5581 ctctttgatg aaccaacatc agctctcgat ccagaaatgg ttggagaggt cctcaaaatc
     5641 atgcaagatc tggctcagga aggcttgacc atgattgtcg taacccatga aatggaattt
     5701 gcccgtgatg tctctcaccg tgttatcttt atggataagg gtgtgattgc tgaagaaggt
     5761 aaaccagaag acctcttcac taatcctaaa gaagaccgta caaaagaatt tcttcaacgt
     5821 tatctcatac tcaatgaaaa tcaaagagca aactaggcag ctagccgcag gttgctcaaa
     5881 acactgtttt gaggttgcag atagagctga cgtggtttga agagattttc gaagagtatc
     5941 aaataaaaag aaaaggctgc atcaaccgtg cagtcttttt gctgtcctca aaatgaaaag
     6001 gcagattctc tatctctact acttgaaggt caagaatcca ccgttatcca aagattaatc
     6061 ttcaaatttt tcatgatttt tttcatagaa atcaattaag cctagggctg tttcaaatga
     6121 aatatttttt acttttgcac gaccctgcgc cagagcaatg atagacattt cacgcgcatt
     6181 cgtttcttta gagatacggt agcctgtgat tttcttatca cgaacccagc caacaactga
     6241 ttctactttt tcaaagtttg acttagccat gtttttctcc tattttcttc tttataatat
     6301 ttaattgtat acgtttttac tacttttgtc aataaaaaaa acatatattc aacgaaaata
     6361 attagttcag aattttctta cttccttttt aaatccgata acatataggt tttgctagcc
     6421 tctacaccat aaatatttgc taataaaaat actgtattat taccctctta aggtgcaaaa
     6481 ttattcaagt tcttaaaaaa tgcttctcta tttccgtaag atagcttatt tcttcgattt
     6541 aagaactgaa gatgatagtt ctaaccttta gaaatccaag ccttctctag ctcaaaaact
     6601 cctatctttc ttcctcaata aatcatctga gagataggta ttccttatat ccttcaaatt
     6661 catcactcct ttggatattg aggtgctagc ctagaagcag acacccgatt atctaaacca
     6721 tccttaatag agatgacaag acagataagc tcagttaatt acttatatat ctttttaata
     6781 tggtatattt gtcaacaaaa agaaatcaaa tcatacctta tactcaatga aaatcaaaga
     6841 gcaaactagg aagctagccg caaattgctc aaaacactgt tttgaggttt cagatagagc
     6901 taacgtggtt tgaagagatt ttcgaagagt attaaagaca gtatgactat gcttgtcaat
     6961 agataggaaa tcaaaatgaa ggatggaaat ctgagccaaa catcataagt gctataatga
     7021 acagaagtaa gaattgcacg ataagttttc taaaaccata ggaatcgtcc cctttcttca
     7081 tcttcattat agcacatata catcagttgt acaaataata tgatattttt ttattagtcc
     7141 tcagacaagc atattataaa gcgtttcatt accatttaag ttaatataag ctggatcaaa
     7201 accttccatt ctacggatca aacctgcata atcatgctta tctgccaaag cgatcccaat
     7261 caatactggg cctgttccct tgctagctcg tttgatatac tcaaaacgtg tgatatcatc
     7321 atttggcccc aggatatcat ttacaaactc acgcaaagct cctggacgct gtgggaaatt
     7381 gaccacaaag taatgtttga taccatcata aatcaaggca cgctcttcca tttctggcat
     7441 acggttgata tcattatttc ctccagaaat gatacaacaa atggttttcc ccttaatata
     7501 ttcagctaaa acctctaaag aggcgatact agccgctcca gcaggttctg cgactatccc
     7561 ttgcttagag taaaggtcaa tcaaggtttc agaaatcaat ccctcatcga cacctaccaa
     7621 agtttgaata tgttgacgag ttgcttcata ggtcaactga cctacctttt gcacagcaat
     7681 cccatccgca aatttatcaa tttccttgag tttgactgga cctccagcct caaaggcagc
     7741 tttcatggaa cgcgctccat tcgcctctac tccgataacc tcaatctctg gacttgtttc
     7801 cttgatatag gtagaaaccc cggcaatgag accgccacca ccaacaggaa ccaagacagc
     7861 atcaaaatca atcgattctt ttcgagcttc ttctaaaatc tcataagcaa ctgttccttg
     7921 acctgcttga acatgagcat catcaaaagg atcaataaag gtacgatttt cagagactgt
     7981 aaattcttga gctgctttgg ctgaggcatc aaaggtatct ccaactagtt taatagttac
     8041 aaaatcccca ccaaaaaagc gaacctgacc aatcttttgt tgtggcgtag taataggcat
     8101 aaagatagta gcaggaattt tcatttcatt acaagtatag gctactccct gcgcatgatt
     8161 tcccgcagaa gcgcagacta ccccacgttc acgttcttcc ttgctgagct gggaaatggc
     8221 ataataggca ccacgaattt taaaggagcg aacacgctgg gcattttctt ttttcaaata
     8281 aatcttagca ccatacttct ccgataaata atgatcgtaa tccagtggag tattcacaac
     8341 cacaccgttc aagaccttgt gagccttgat tatatctttt gaacttaaca tataaaacct
     8401 ctttttctat aaaaaacagt cactaatgac tgttttttag ttattcatct ccgaaaactt
     8461 cagtaacact ttcatggtat ttatgagcca tacgaatcga aaactcttta ggaagttcat
     8521 aacgatttgt ggaaatccaa tcatataacc attctaccaa actttcttca ctatcattac
     8581 gatggaagat aaaatagttt aaaatttctt tatattctac atcattcaaa tccaacgtgt
     8641 ctacaaattg actacgagga acaaaattag aatctaattt tcttagttga tctgtcaatt
     8701 ctcccaattg taaatccaac tgaaaaaata gtttttgcag ttgcctatca gtttcatcac
     8761 atcctgtctt gatagaaaac aaattggtaa tattcatatg atttcaaccc ctaaataagt
     8821 acatctaata tcccacgaat agctgaagct aaagttttcg cagtccagtc atttaaaccc
     8881 gattctttca atccagatgc aataatttgc tctatttgat ataaaccgcc atctatcgtc
     8941 tcatttattc tgcgaagagg accttcaata taggataaag cttctccgaa tctaacagct
     9001 gatttaggtc ctaatgattt accaactata tttgttaatg ttttttattt ctcaaaatcc
     9061 atttcgctat ataacgagca gatttagtcg caccagctct ctcaaacgga gaatgaattt
     9121 caagaccttc ttctctagct atttgtgcca atttgaagaa ttgttcaaag gtcatatgca
     9181 acctaccatc ttcaaaatta gcatcatcat aaatgttaat tacagcattt tcatcatacg
     9241 accaatctgc tttattttgg tctgctagca ctattaccga cggtgtaatt acattataca
     9301 actagaacca ataataacga tgcaattttt ctcataatct ttttcataaa atcatctcca
     9361 gcgctatata tttctaatta gttatagatt ttgaatgcat catcgtcgtt tttaccaaca
     9421 aatggcattg ctttacgcaa ttctgcacca actttttcaa tttcaaggtt agctgcttgt
     9481 tcacggtaag cagtcaattt tggacgtcca gctttatagt catttacaaa gtcatttgca
     9541 aatttaccat tttggatgtc tgccaagaca gccttcatat tttctttaac ttgttcagtg
     9601 attacacgtg gacctgatac atagtcaccg tattcagcag tgtttgaaat agattgacgc
     9661 attttcttga atccaccttc gtagatcaag tcaacgatca atttcatttc gtgaagaact
     9721 tcaaagtaag ccaattctgg agcgtaacct gcttctgtca agacttcgaa acctgcttcg
     9781 ataagggcag tcaaaccacc acaaagtaca gcttgttcac caaacaaatc ttcttcagtt
     9841 tcttctttgt aagttgtttc aagaagacct acacgagccg ctccaacacc tttacaccag
     9901 tccatagcaa tgtttttagc atttcctgtt gcatcttggt atactgcata aagagctgga
     9961 acaccaaatc cttcttcgta agtacgacgt accaagtgtc ctggtccttt aggagcacac
    10021 atgaagacat ctacatccgc aggaactttg ataaattcaa agtggatgtt gaaaccatgg
    10081 gcaaatccaa ctgcgtttcc agcttccaag cttggagcga tttctgcttc gtacaattct
    10141 tgttgaattt cgtctggcgc caagatcatg ataacatcag ccaacttagt agcttctgct
    10201 actgtgtaag tatcaaatcc atcttctttt gctttatcaa aagatttacc tggacgtaca
    10261 ccgataataa cgtcacgacc tgaatcacgc aagttttgag catgcgcatg cccttgtgaa
    10321 ccataaccga taacggcgat ttttttaccg tcaagtgctg ctactttaac atctttttca
    10381 tattccattt gaactgtcat agcttttctc tcttttctat tatttattgc cttttaggct
    10441 ggtttaataa atttaagttg gatttttaat cgcgggtaaa tccagttgca cccgttcgag
    10501 caatattgcg aataccgtat gggcgaatga ctcgcaatag ggcttcgctc ttttctgcat
    10561 ttcccgtcat ctgaatggta atcgagctcg gcgctacgtc taccactgtt gcacggaaag
    10621 gttgaataat cgctaaaatc tcagctctct tctcagctgg cgctgacatc ttaaccaaaa
    10681 tcacctcgcg ctccaaatga ggcttgtctg taatatctcg aatgcgaatc acatcaatct
    10741 gacgattgag ctgtttgatg atttgctcca cttcatcatg agaagcaaca tcaataataa
    10801 tagtgatacg cgatacattc ggatcttctg ttgctccaac agagatgctt tcaatattaa
    10861 cctgacgacg agataggaca cctgtaaagc gattgaggac tcctgaacga ttttgtagtt
    10921 ttgctgttaa cattctacgc atggaactgc acccccaaca tctcatgatt actcttacca
    10981 gccggtacca ttggtaacac ctgttcctta cgagaaatat ctacctcaat tagcatagga
    11041 acatcctcag tgatgacttc aaggtcttga gccaaggtct caggattgtc aaacttatag
    11101 tttttaatac cataagcctg cgccatcaat tggaaatcag gaagggtatc aaagaccgac
    11161 tctgatgttc tgccttcata gaaggattcc tgccactggc gaaccattcc gagtgaatga
    11221 ttgttcagca taaccacctt gattggcacc ttgtaaatat tcaaaatagc caactcctgg
    11281 ttggtcattt ggaaaccacc atccccaaca aacaagacta cttccttatc tgggttagca
    11341 attttagcac cgattgctgc tggaattcca aagcccattg ttcccaaacc acctgaagtc
    11401 actaactgac gttcattttg gtagggataa tactgagctg tccacatttg gtgttgacca
    11461 acgtctgtta ccacaatggc atctccattc gtcaattcac caattcgttc aataactgct
    11521 tgcggttgaa ccacacgctc tttcttgtca taagaacgaa cacgattctt gtctttagtg
    11581 actttctcaa tccacttttc agtattgttg tgaactgttg gttctgctag caacatttgc
    11641 aaggccttct tagcatctcc aactacagga atgtctgcac tgataatctt gccaatctca
    11701 gctgggtcaa tatcaatgtg ggcaacctta gcattcttag cgaaagtctt aggattcccc
    11761 gtcaaacggt catcgaaacg agaaccaata ctaatcataa agtccgcttc cgtcatggca
    11821 atatttgctg cgaatgaccc gtgcatgcct cccattccaa gaaagagtgg gtgactcgtt
    11881 gcaatcgttc cttgtcccaa aagactggtt accactggaa tttgatagcg ttctgcaaat
    11941 tcatttagtt ccgtagcagc ctcagcataa ctaattccac caccagctaa caagactggc
    12001 tttttagcct tggacaattg cttcaagatt ttcttgattt gcatatcatt cggctcaaga
    12061 gtcggctgat aacttggtaa attcacttct ggtgaataaa tgaagtctgt ttctaaagca
    12121 gatatgtctt ttggtaggtc aattacaact ggccctggac ggcctgtagt tgcgatatgg
    12181 acagcttccg taatgatacg cggaatatca gctgtctcac gaacttggta attgtactta
    12241 gtgattggca tggtaattcc cacgatgtct gcctcctgaa aggcatcctt cccaatccct
    12301 gctcgcgcca cctgacctgt aaagaccaaa aggggaacgc tatcgctcat ggcatccgca
    12361 atccctgtaa tggcatttgt tgctcctggt ccactagtga cgacggcaac acccaacttt
    12421 ccagttgatt tggcataacc ttcagcttca tgcaaacaac cttgctcatg gcgccctaga
    12481 atgtggcgaa tgcctttaaa attatatatc gcatcataaa aaggcaaaac cgcaccacca
    12541 ggataaccaa agatggtatc aactcctaaa tcacgaagtg tttccaaaac taggtccgac
    12601 cccgtcttag gagattctaa actgattttc tccattgttc ccctttcttt cctcttaaaa
    12661 ataacttgtt actatcatac cattttttca aaatttttca agataaaaga agaaattttc
    12721 tgaattttct attttaacgt ttatttatga atgttatttt tgtttttatt aaaaagatac
    12781 cgatttcatt tactaaaaaa gaaaaaagaa ctgatttctc agtccttcat taatcggctc
    12841 tataatattt gtagtgggta aatccactat agatattatg gagcctattt tattgtagaa
    12901 aaaaagtccc atatgaccta taatgaaaag cgacaaaacc
//
LOCUS       DBERMM010000049        12347 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.051, whole genome shotgun sequence.
ACCESSION   DBERMM010000049 DBERMM010000000
VERSION     DBERMM010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12347)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12347)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12347
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.051"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            88..1266
                     /locus_tag="ACL8AS_001806"
     CDS             88..1266
                     /locus_tag="ACL8AS_001806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229617.1"
                     /translation="MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSLMFNGIGRSNC
                     VCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKA
                     QKKEKIKVNKSDFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEP
                     KKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAK
                     QYADNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERAIKAKQYQKELE
                     KDQRIASQDPIERKQKQTWLLNSYFRELPEEKARFSRLLLEYRKSGEVPFSTEYLSDH
                     LIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLGRLVI
                     "
     gene            1475..7048
                     /locus_tag="ACL8AS_001807"
     CDS             1475..7048
                     /locus_tag="ACL8AS_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ZmpA/ZmpB/ZmpC family metallo-endopeptidase"
                     /protein_id="HGS1229618.1"
                     /translation="MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQE
                     TAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSK
                     NERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLL
                     NYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDY
                     NVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQL
                     AEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEI
                     QENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPIPRIVEKGTK
                     KTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGVPEVQPALPEAVVTDKG
                     EPAVQPELPEAVVTDKGETEVQPESPDTVVSDKGEPKQVAPLPEYTGPQASAIVEPEQ
                     VAPLPEYTGVQAGSIVEPEKVEAPKEYTGKIEQPSAEDTKPENEASSTNGESERPKDK
                     IKEEKQVDKKLELRNVSNVELYTVENNKYRHITAVDGALDSSLKYFMKVKSENFKDIM
                     LPVTKIESTTKNNKEVYKIVAHAENLIQHENNVISNDYTYYLPKTQQSETGVYTSFKN
                     LVDAMNSDPNGTFHLGATMDAREVELPDDQESYVKNEFYGKLIGENNGKYYAIYNLKK
                     PLFKTLNTATIQNLSIKEANVSSKEDAATISKEAKYNTLIDNVHSDGIIAGERGIGGL
                     VSKVDNSRISNSSFTGRITNTYDTTVGYEIGGLVGKLSGSLASIEKSIASIDIASNAK
                     SGDQIVGGIAGVVEKSATIKYSYVEGNVNNVRHFGKVGGVAGNLWDRDSQDVSKSGKL
                     SYVLSDVNVTNGNAISGDNFDNMKEDHAYSSKGNKVVNVVQVDDELVTKDSDVQRGTV
                     LDADKVKEKKAELVSKHSTKVEDFDFTSRYTTIYNEVTGYQKSREQVYKNIEKLLPFY
                     NRETIVKYGNLVDESSELFTKELLSVVPMKNNEVITDINKNKQEINKLLLHFEGNKSQ
                     VLNIAYKNDFSKVAEYSIEYQGLLYTPNTLLHDYSNIVDNVLTDLNSVQYDSNAIKKI
                     LDISDKVKNTELYLDEQFVKTKANIKDTLSKLLSADAAIAENSNSIIDNYVIQKIKQN
                     KEALLLGLTYLERWYNFKYGETKAKDLVMYHLDFFGKSNSSALDNVIQLGKSGFNNLL
                     AKNNVITYNVLLSKNYGTESLFKALEGYRKVFLPTTSNNEWFKAQTKAYIVEEKSSIP
                     EVSKKQSEQGTKYSIGIYDRLTSPSWKYQSMVLPLLTLPEEKTVFMIANISTIGFGAY
                     DRYRSKVHPKGDNLNKFVEDNVREAAKRFRDHYDYWYKILEPENREKLYRSLLVYDAF
                     KFGRDNTEDKVTYQADFETDHPAIKYFFGPAGNNVVHNGHGAYATGDAFYYMAYRMLD
                     KDGAVTYTHEMTHNSDREIYLGGYGRRSGLGPEFYAKGLLQAPDHPYDPTITINSVLK
                     YDDSENSTRLQVADPTQRFNSAEDLHNYMHNMFDLIYTLEILEGRAVAKLDYNAKNDL
                     LRKIENKYKQDPDGNSVYATNVVRRLTMDEVNKLNSFDSLIENDIITSRGYKDQEYKR
                     NGYYTIDLFSPIYSALSGEKGTPGDLMGRRIAFELLAAKGYKEGMVPYISNQYEKDAK
                     AAGSKIKSYGKEVGLVTDKLVLEKVFNNRYSSWVEFKKAMYNERIAKFNNLISVSFNN
                     PNVSWGRTNRITITSIANLQNMINTAVNEDAEDFRAQLYPDTNSRVLKLKKAIYKAYL
                     DQTNDFRRSIFENKK"
     gene            7092..12329
                     /gene="zmpD"
                     /locus_tag="ACL8AS_001808"
     CDS             7092..12329
                     /gene="zmpD"
                     /locus_tag="ACL8AS_001808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000054777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease ZmpD"
                     /protein_id="HGS1229619.1"
                     /translation="MSLLKKDKFSIRKIKGIVGSIFLGSFLFALSVVGVSTYHYLDYS
                     TLTQTERDQLKQGRPDESKESYALVYEKDALPNTGSSQSIMTVLGLLAIGSLIVIITK
                     DKKRKKIATFLIVGATGLVTLSTASALNLNANIHESGRDGVLQISGYRYVGYLELDDR
                     TVSSVSPASTVSPVEQPKVVTDKGEPEVQPALPEAVVTEKGEPEVQPALPEAVVTEKG
                     EPEVHEKPDYTQPIGANLVEPEVHEKLAYTEPVGTTGVDENGNLIEPPVNDIPEYTEP
                     ISTVSEVASEREELPSLHTDIRTETIPKTTIEESDPSKFIGDNSVKQVSEDGERQIVT
                     SYEELHGKKISESVETVTILKEMKPEIIVKGTKEKTAPVLTLTKVTEDAMNRSANLNY
                     ELDNKDNAEISSIVAEIKDGDTVVKRVDLSKEKLTDAVQNLDWFKDYKIATTMIYDRG
                     QGSEMSKLDERPLRLELKKVEIKNIASTNLVKVNDDGTETPSDFMNEKPSEEDVKKMY
                     LKITSRDNKVTRLTVDSIEEVTEEGQKLYKITAEAQDLIQHTDPTKVRNKYVYYIEKP
                     HPKEDNVYYNFKDLVDAMNTDKNGTFKLGADLNATGVPTPKKWYVDGDFRGTLKSVEG
                     KHYTIHNTERPLFQNIIGGTVTKVNLGNVNINMPWADRIAPIADTIKGGAKIEDVKVT
                     GNVLGRNWVSGFIDKIDNQGTLRNVAFIGNVTSVGDGGQFLTGIVGENWKGLVERAYV
                     DANLIGKKAKAAGIAYWTQNSGDNHKVGVEGAVKKGIVKGTIQVESPVEVGGAVGRLS
                     HHGYIGEVVSMMKVKKGEIFYGSSDMNDDPYWVANNVRGNYVVNGVSEGTISYARAKE
                     HHRIKPISQSEADTKIMMLGITAQDFAINEPVVNRLNRLTRKEDEYKSTQDYKVDRDL
                     AYRNIEKLQPFYNKEWIVNQGNKLAEDSNLAKKEVLSVTGMKDGQFVTDLSDIDKIMV
                     HYADGTKEEMDVTKNADSKVKQVREYTIAGQNVVYTPNMVEKDRNQLIQDIKDKLASV
                     QLISPEVRALMDARKKPEENTDERKNGYIKDLYLEESFAETKANLDKLVKSLVENADH
                     QLNSDETAMKALVKKVDENKAKIMMALTYLNRYYDIKYGDMTIKNLMMFKPDFYGKSV
                     DLLDFLIRIGSSERNIKGDRTLDAYRDMIGGTIGKSELHGFLDYNMRLFTNDTDLNDW
                     FIHAAKNVYVSEPQTTNPDFVNKRHRAFDGLNNGVHNRMILPLLTLKNAHMFLISTYN
                     TMAYSSFEKYGKYTEEARNEFKKEIDKVAHAQQTYLDFWSRLALPSVRDQLLKSENRV
                     PTPVWDNQNYSGIKGINRMGYDEKKVPIAPIRELYGPTWKFHNTNWNMGAMASIFPNP
                     NNNDQVYFMGTNMISPFGISAFTHETTHVNDRMLYFGGHRHRQGTDVEAYAQGMLQTP
                     SSIGHQGEYGALGLNMAYHRENDGDQWYNYDPDKLQTREDIDRYMKNYNEALMMLDHV
                     EADAVLPQLNGDNSKWFKKIDREMRRNLGDGLNNLVAPHQWDNVRDLNQEESSKKLSS
                     INDLIDNNFMTKHGNPGNGRYRPEDFRPNSAYVNVNMMAGIYGGNTSQGAPGSLSFKH
                     NAFRMWGYYGYDKGFTSYVSSKYQGEADKQNQGRLGDDFIIKKVSNNQFSNLEDWKKY
                     WYHDVKSRAEKGFTEITIDGQTIHNYNELKDLFDKAVTEDLKKAGNYSNTENLKSKVF
                     KALLKNTDGFFNPLFKKDI"
BASE COUNT         4548 a         1861 c         2462 g         3476 t
ORIGIN      
        1 acaacctcaa aacagtgttt tgagctgact gcggctagct ttctagtttg ctctttgatt
       61 tttattgagt attagaaagg agacctcatg acacttccag ttagaaaatc cctgcacgat
      121 gcagttttac aggcttcgaa agcggatact tgggaacaag ctaccaagga atggaatgaa
      181 gtttccttga tgtttaacgg tatcggccgt agcaattgtg tctgtggaaa tgccatcaaa
      241 tacgcttatg aactctttaa cggtgtcaca ggccaacgcc tctttccaat tggtagcgac
      301 tgtgttcgtc attttcatcg attgtccctt gaccagcaat tggaagagga agaaaaactg
      361 ctcagaaagg ttgaaaatct aaccagaaaa gctcagaaaa aggaaaaaat caaggtcaat
      421 aaaagtgact ttgacgagcg acttctaaaa tggctctggg aaaaaggtgt tttcaaaccc
      481 aatcgtggca atcaatttgc gcctgagaga gactaccagc ttttcctaga agtctttcag
      541 ggaggaagtt ggaccaaggc ggaaccaaag aaaaaggctc ggatggaaga agtccttgaa
      601 aagtgtatca aacccttttt acttgggaaa tcggatgacc aactctacct tgtcaagcta
      661 ggcaaggaga aaattgacta cgaacaagaa ctccgtatcc aggcagagaa agaacgcaag
      721 aagagggata aaatcgccaa gcaatatgca gataatctgg ttctagccat gggacccgca
      781 gagcgtgctt atcaagatta ctttggcttt acagagaccc tgactcaaga agaacgcaag
      841 tgggaaaaaa ttctttttgg taaaaataga gcagaacggg ctatcaaggc caaacaatac
      901 caaaaagagc tggaaaaaga ccaacgaatt gccagtcagg atccaattga aagaaaacag
      961 aagcagactt ggctcctcaa ttcctatttt cgagagcttc ctgaagaaaa agctcgattt
     1021 tctaggctct tattagaata tcgaaaaagt ggtgaagtac ccttttcaac tgaatacctg
     1081 tcagatcatc tcatcgactt tttctataaa atgaaagcct ttgaatttga aatcgcacca
     1141 gaacaagtcc gagattttct aaaaaaaagc ctgcaggaag accatcgctc atcagcacaa
     1201 ggaagctgga tagaaggaat tctcctcaac tgcctcaaac catttttagg acgattagtg
     1261 atatgagtaa cacctaccgt gtaaatttca tggtaggtgt tattgtaccc caaaataata
     1321 taaaacaaag tatgaaagcg catctcaatt ttaagacttt tttgtaaatt aagagtataa
     1381 ttaaggtata ctgccttttc tatagataat agataataca ctaatataat aaaggtcttt
     1441 gtaacatata taaattttat ttcaaggagg aataatggaa aagtattttg gtgaaaaaca
     1501 agagcgtttt tcatttagaa aattatcagt aggacttgta tctgcaacga tttcaagttt
     1561 attttttatg tctgtattag ctagttcatc tgtggatgct caagaaactg cgggagttca
     1621 ctataaatat gtggcagatt cagagctatc atcagaagaa aagaagcagc ttgtctatga
     1681 tattccgaca tacgtggaga atgatgatga aacttattat cttgtttata agttaaattc
     1741 tcaaaatcaa ctggcggaat taccaaatac tggaagcaag aatgagaggc aagccctagt
     1801 tgctggtgct agcttagctg ctctgggaat tttaattttt gctgtttcca agaaaaaggt
     1861 taagaataaa acggtattac atttagtatt ggttgcggga ataggaaatg gtgtcttagt
     1921 ttcagtccat gctttagaaa atcatctttt gctaaattac aatacggact atgaattgac
     1981 ctctggagaa aaattacctc ttcctaaaga gatttcaggt tacacttata ttggatatat
     2041 caaagaggga aaaacgactt ctgattttga agtaagtaat caagaaaaat cagcagccac
     2101 tcctacaaaa caacaaaagg tggattataa tgttacacca aattttgtag accatccatc
     2161 aacagtacaa gctattcagg aacaaacacc tgtttcttca actaagccga cagaagttca
     2221 agtagttgaa aaacctttct ctactgaatt aatcaatcca agaaaagaag agaaacaatc
     2281 ttcagattct caagaacaat tagccgaaca taagaatcta gaaacgaaga aagaggagaa
     2341 gatttctcca aaagaaaaga ctggggtaaa tacattaaat ccacaggatg aagttttatc
     2401 aggtcaattg aacaaacctg aactcttata tcgtgaggaa actatagaga caaaaataga
     2461 ttttcaagaa gaaattcaag aaaatcctga tttagctgaa ggaactgtaa gagtaaaaca
     2521 agaaggtaaa ttaggtaaga aagttgaaat cgtcagaata ttctctgtaa acaaggaaga
     2581 agtttcgcga gaaattgttt cgacttcaac gactgcgcct attccaagaa tagtcgaaaa
     2641 aggtactaaa aaaactcaag ttataaagga acaacctgag actggtgtag aacataagga
     2701 cgtacagtct ggagctattg ttgaacccgc aattcagcct gagttgccag aagctgtagt
     2761 aagtgataaa ggcgtaccag aagttcaacc agcgttaccg gaagcagtcg taaccgacaa
     2821 aggtgagccc gctgtccaac ctgaattacc cgaagctgtt gtaactgaca aaggtgagac
     2881 tgaggttcaa ccagagtcgc cagatactgt ggtaagtgat aaaggtgaac ctaaacaggt
     2941 agcaccgctt ccagaatata caggaccaca agccagcgct attgttgaac cagagcaagt
     3001 agcaccacta ccagaataca caggggtaca agccggatcg atagtcgagc cagagaaagt
     3061 agaagcaccg aaagaatata ctggtaaaat cgaacaacct agtgcagaag atactaaacc
     3121 tgaaaatgag gcaagctcta caaatgggga atcggaacgt cctaaagata aaattaaaga
     3181 agaaaaacaa gtcgacaaga aactagaact tagaaatgtt tcaaacgtgg aattatatac
     3241 ggtagaaaat aataaatatc gacatattac ggctgtagat ggtgctttag atagttcatt
     3301 gaagtatttc atgaaggtaa aatcagaaaa ttttaaagat ataatgttgc ctgttactaa
     3361 aattgaaagt acaacaaaaa acaataaaga agtatacaaa attgtggctc atgcagaaaa
     3421 tctaattcaa cacgaaaaca atgttatttc gaatgactat acatattatt taccaaaaac
     3481 tcagcaaagt gaaactggcg tctatacatc atttaaaaat ttagttgatg caatgaatag
     3541 tgaccctaat ggaacattcc atttaggtgc aactatggat gctcgtgaag ttgaacttcc
     3601 ggatgatcaa gaaagttatg taaaaaatga attttacgga aaattaatag gtgaaaataa
     3661 tggtaagtat tatgctattt ataacttgaa aaaaccttta tttaaaactc taaacaccgc
     3721 tactattcag aatctttcaa taaaagaagc gaatgtttct tctaaagaag atgctgctac
     3781 aatatcgaaa gaagcaaaat acaatactct tatagataat gttcattctg atggtattat
     3841 agctggtgaa cgtggaattg gtggattggt ttcaaaagta gataactcga gaatttctaa
     3901 tagtagtttt acaggcagaa taactaacac atatgataca actgtagggt atgaaattgg
     3961 tggtttagta ggtaaacttt ctggttcgct tgcttctata gagaaatcaa tagcatcgat
     4021 tgacatagcc tctaatgcaa aatcaggaga tcaaattgtt ggtggtatag ccggagttgt
     4081 tgagaaaagt gcgacaatta agtatagcta tgttgaagga aatgttaaca atgtgcgaca
     4141 ctttggtaaa gttgggggag ttgcaggtaa tctttgggat agagattcac aagatgtaag
     4201 taaatcaggt aaactatcat atgttttaag tgatgttaat gtaacaaatg gtaatgctat
     4261 atcgggtgat aattttgata atatgaaaga agatcatgct tatagtagta aaggcaataa
     4321 agtagtaaat gtagtccaag tagatgatga acttgtgact aaagattcag atgtacaaag
     4381 aggtacggta ttagatgctg ataaagtaaa agagaaaaag gcagaattgg tttccaaaca
     4441 cagcactaaa gtagaagatt ttgatttcac ttcaagatac actactattt acaatgaagt
     4501 aacaggttat caaaagtcga gagaacaagt atataaaaat attgaaaaac tattaccgtt
     4561 ctataatcga gagacaattg ttaaatatgg taatttagta gatgaaagca gcgagctatt
     4621 tactaaagaa cttctatcag ttgttcctat gaagaataat gaagtaataa ctgatattaa
     4681 taaaaataaa caagaaataa acaaattgtt attacatttt gaaggtaata aatcacaagt
     4741 attaaatatt gcatataaga atgatttctc taaagttgct gagtatagta tagagtatca
     4801 aggattatta tatactccca atactctatt gcatgactac agtaatattg tagataatgt
     4861 tttaactgac ttgaattctg tacaatatga ttcaaatgca attaagaaaa tattagatat
     4921 ctcagataaa gttaaaaata cggaattata cttagatgag caatttgtta aaacaaaagc
     4981 aaatataaaa gatactttat caaaacttct gtcagcggat gcagcaatcg ctgagaatag
     5041 taattcgata attgataatt atgttattca gaaaatcaaa cagaataaag aagctttatt
     5101 gttaggatta acatacttag agcgttggta caattttaaa tatggtgaaa cgaaagcaaa
     5161 agatttagtt atgtatcact tggatttctt cggtaaatct aatagttctg cattagataa
     5221 tgttattcaa ttaggtaaat ctggatttaa caatttacta gcaaaaaata atgtaattac
     5281 ttacaatgta ttattatcta aaaattatgg aactgaaagt ttatttaaag cattagaagg
     5341 atatagaaaa gtattcttac caacaacttc taacaatgag tggtttaaag ctcaaactaa
     5401 agcatatatt gttgaagaaa aatcttctat tccagaagta agtaaaaaac aatcagaaca
     5461 aggaactaag tattctatag gaatttatga tagattaact agtccgtcat ggaaatatca
     5521 aagtatggtc ttaccactat taactttacc tgaagaaaaa acagtattta tgatagcgaa
     5581 tatttcaaca ataggatttg gtgcttatga tagatataga agtaaagtcc atcctaaagg
     5641 agataactta aataaatttg tagaagacaa tgtaagagaa gctgcaaaaa gatttagaga
     5701 tcattatgat tattggtata aaatattaga gcctgagaat agagagaaac tttatagaag
     5761 tttattagta tacgatgcat ttaaatttgg tcgagataat actgaagata aagtaactta
     5821 tcaagctgat tttgaaactg atcatccagc tataaaatac ttctttggac ctgcggggaa
     5881 taatgttgtt cataatggac acggagcata tgctaccgga gatgcattct attatatggc
     5941 atatcgtatg ttggataaag atggagctgt aacatatact catgaaatga cacataactc
     6001 tgatagagaa atttatcttg gaggatatgg aagaagaagc ggattagggc ctgagtttta
     6061 tgctaagggc ttattacaag cacctgacca cccatatgat ccaacaataa caattaactc
     6121 tgtgttgaaa tatgatgatt cagaaaattc aacaagactt caagtagctg atccaactca
     6181 acgatttaat agtgcagaag acctacataa ttatatgcat aatatgtttg atttaatata
     6241 tactcttgaa atattagaag gtcgtgctgt agctaaatta gattataatg cgaaaaatga
     6301 tttattaaga aaaattgaga ataaatataa gcaagatcca gatggtaatt ctgtttatgc
     6361 gacaaatgtt gttcgcagat taacgatgga tgaagttaat aaattaaatt cttttgatag
     6421 tttaattgaa aatgatatta ttactagcag agggtacaaa gaccaagaat ataagagaaa
     6481 tggttattat acaattgatt tattttcacc gatttattca gctcttagtg gagagaaagg
     6541 gactcctggt gatttaatgg gacgtcgtat agcattcgaa ttattagctg caaaaggata
     6601 taaagagggc atggtacctt atatctcaaa tcaatatgaa aaagatgcaa aagctgcggg
     6661 aagtaagatt aaatcttatg gtaaagaagt aggtttagtt acagataaat tagtacttga
     6721 aaaggtattt aataatcgtt actcatcttg ggtagaattt aaaaaagcaa tgtataatga
     6781 gcgaatagct aaatttaata atctaataag tgttagcttt aataatccaa atgtaagttg
     6841 gggaagaact aatagaataa caataactag catagccaac cttcaaaata tgataaatac
     6901 ggctgtcaat gaagatgctg aagattttag agcacaatta taccctgata caaatagtag
     6961 agttcttaaa ctgaaaaaag caatatataa agcctatctt gaccaaacaa atgattttag
     7021 aagatcaatt tttgagaata aaaaatagtg tttactatta ggaaataaaa agtgaatgtg
     7081 gaggattaga attgtcatta ttaaaaaaag ataaattttc cattaggaaa ataaagggta
     7141 ttgttggttc gatattcttg gggagttttt tatttgcact gtcagttgtt ggtgtatcga
     7201 cttatcatta cttagattat agtactttga cacaaactga acgtgatcaa ctcaaacaag
     7261 gtagacctga tgaatcaaaa gagtcatatg ctttggttta tgaaaaagac gcattaccaa
     7321 acacaggaag ttctcaatct attatgactg tattgggttt gttagctatc gggagtctta
     7381 ttgtgattat cacaaaagat aaaaagagga aaaaaatagc tacatttttg attgtagggg
     7441 cgacaggttt agttacacta tcaactgctt cagcacttaa tttgaatgct aacatccatg
     7501 agtctggacg tgatggtgtg ttgcaaattt ctggttacag atatgttggt tacttggagc
     7561 ttgatgatag aactgtttcg tcggtttctc cagcatcaac tgtttctcca gttgagcaac
     7621 ccaaagttgt gaccgacaaa ggcgaaccag aagttcagcc agcgttacca gaagcagttg
     7681 taactgaaaa aggggaacca gaagtacaac cagccttacc cgaagcagtt gtaactgaaa
     7741 aaggggaacc agaagttcat gagaagcctg actatacgca accaataggt gcaaaccttg
     7801 ttgagcctga agttcatgag aaactagcat acactgaacc tgtaggtaca acaggagtag
     7861 atgaaaatgg aaacttgatt gagccacctg ttaacgatat tccagagtat actgaaccaa
     7921 tatctacagt ttcagaagtt gcatcagaaa gagaagagtt gccttcttta cataccgata
     7981 ttcgtacaga gactattcct aaaaccacta tagaagaatc tgatcctagc aaatttatag
     8041 gcgataattc tgttaaacaa gttagtgagg atggcgaacg tcaaattgtt actagctatg
     8101 aagagttaca tggcaaaaaa atcagcgagt cagttgaaac agtaacaatt ttgaaagaaa
     8161 tgaagcctga aattattgta aaaggtacaa aagaaaaaac ggctcctgtt ttaaccttga
     8221 ccaaagtaac agaagatgct atgaatcgtt ctgccaactt aaattatgag cttgataata
     8281 aagataatgc tgaaatatca agtattgtag ctgaaattaa agatggtgat acagtagtta
     8341 aaagggttga tttatctaaa gaaaaattaa ctgacgctgt acaaaatttg gattggttta
     8401 aagattataa gattgcaaca acaatgattt atgatcgtgg tcaaggttct gaaatgtcta
     8461 aactggatga aagacctctg cgtttggagt tgaaaaaggt cgaaattaaa aatatcgcat
     8521 ctactaattt agtgaaggta aatgatgatg gtactgaaac acctagtgat tttatgaatg
     8581 aaaaaccttc agaagaagat gttaaaaaaa tgtacttaaa aatcactagt cgcgataata
     8641 aggtaactcg tttaactgta gactctattg aagaagtgac tgaagaaggt caaaaacttt
     8701 acaaaataac tgctgaagca caagatttga ttcaacacac agacccaacg aaggttcgta
     8761 ataagtatgt ttattatata gaaaaacccc atcctaaaga agataatgtc tactataact
     8821 ttaaagattt agtagatgct atgaatactg ataaaaatgg tacatttaaa cttggtgcag
     8881 atttgaatgc cactggtgtt ccaacaccta agaaatggta tgttgacggc gactttagag
     8941 gtacattgaa gagtgtagag gggaaacatt atactatcca caacacggag cgtccgttat
     9001 tccagaatat tattggtggt acagtaacca aagtaaatct gggaaatgta aatatcaata
     9061 tgccatgggc agaccgcatc gcaccgattg ctgacactat taaaggtggc gctaaaattg
     9121 aagatgtcaa agtgactggt aacgtattag gtagaaactg ggtatctgga tttattgata
     9181 agattgacaa ccaaggtaca ctcagaaatg tagcctttat cggaaatgtg acatctgtag
     9241 gtgatggtgg tcaattcttg accggtatcg ttggtgagaa ctggaaagga ctagtcgaac
     9301 gtgcgtatgt tgacgcaaat cttattggca agaaagccaa ggctgctggt attgcttatt
     9361 ggacacaaaa cagtggtgac aatcataaag ttggtgtcga aggtgcagtc aagaaaggaa
     9421 ttgtgaaggg taccattcag gtagaaagtc ctgttgaagt cggcggtgct gttggacgtt
     9481 tgagtcatca tggttatatc ggggaagtcg tatctatgat gaaagttaag aagggtgaaa
     9541 ttttttatgg ttctagtgat atgaatgatg acccatattg ggtggcgaat aatgtacgag
     9601 gaaattatgt cgttaatggt gtgagtgaag gtacgatatc ttatgctcgt gctaaagaac
     9661 accatcgtat caaaccaatt tcacagtcag aagcagatac taaaattatg atgttaggta
     9721 ttacagcaca agattttgct atcaacgaac ctgtggtcaa tcgcttaaac cgtttaacca
     9781 gaaaagaaga tgaatataag tcaacccaag actataaagt agatcgagat ctggcttatc
     9841 gtaatattga gaaacttcaa ccattttata acaaagaatg gattgtcaac caaggtaaca
     9901 aacttgcaga agattcaaac ttagctaaga aagaagtcct ttctgttacg ggtatgaagg
     9961 atggacagtt tgtaactgac ttatcagata ttgataagat tatggttcac tatgctgatg
    10021 gtactaaaga agaaatggac gtcactaaga atgctgattc taaagtgaaa caagttcgtg
    10081 aatataccat cgctggacaa aacgttgttt atacaccaaa tatggttgag aaagaccgta
    10141 accaattgat tcaagatatc aaagataagt tggcgtcagt tcaattgatt tctcctgaag
    10201 tacgtgcttt gatggatgca cgtaagaaac cagaagaaaa tactgatgaa cgtaagaatg
    10261 gttatattaa agacctttac ttagaagaaa gctttgctga aacgaaagct aatcttgata
    10321 aattggttaa atccttagtt gaaaatgcag atcatcaatt aaatagtgac gaaacggcta
    10381 tgaaagcact tgttaagaag gtggatgaaa ataaagctaa aatcatgatg gctctgactt
    10441 atctcaatcg ttactatgat atcaagtatg gggatatgac tatcaagaac ttgatgatgt
    10501 ttaaacctga tttctatggt aaatcagttg accttcttga tttcttgatt cgaattggat
    10561 caagtgagag aaatatcaaa ggtgacagaa ctttggatgc ttatcgtgat atgattggtg
    10621 gaactattgg taagtctgaa ttacatggat tcttagatta caatatgcgt ctcttcacta
    10681 acgatactga tttaaatgat tggttcatcc atgcagctaa gaatgtatat gtatcagaac
    10741 ctcaaacaac gaacccagat tttgttaata aacgacatcg tgcatttgat ggtttgaaca
    10801 acggtgttca taatcgtatg attctacctc tattaactct taagaatgca catatgttct
    10861 tgatttcaac ttacaataca atggcttata gttcttttga gaaatatggt aagtatacag
    10921 aagaagctag aaatgaattc aaaaaagaaa ttgataaggt tgcacatgct caacaaacat
    10981 acttagactt ctggtcacgt ttagcattgc caagcgtacg tgaccaatta ctcaagagtg
    11041 agaatagggt accaactcct gtgtgggata accaaaacta tagtggtatt aaaggaataa
    11101 accgtatggg ttatgatgag aagaaagtac caattgcgcc aattcgtgag ttatatggtc
    11161 caacttggaa attccataat accaactgga atatgggagc tatggcatct attttcccaa
    11221 atcctaataa caatgaccaa gtttatttca tgggaacaaa tatgattagt ccgtttggta
    11281 tttcagcctt tactcatgaa actacacacg ttaatgatag aatgctttac ttcggtggtc
    11341 atagacaccg tcaaggtaca gacgtcgaag cctatgctca aggtatgcta caaactccgt
    11401 caagtattgg tcaccaaggt gaatatggtg ctttaggttt gaacatggct tatcatcgtg
    11461 aaaatgatgg tgaccaatgg tataactatg accctgataa gcttcaaact cgtgaagata
    11521 tcgatcgata tatgaaaaac tataatgaag cactgatgat gctagatcat gtagaagcag
    11581 acgccgtact tccacaattg aatggtgata atagcaagtg gttcaagaaa attgatagag
    11641 aaatgcgcag aaatcttggg gatggtttga ataacttagt agcaccgcac caatgggaca
    11701 acgttcgtga cttaaatcaa gaagagagtt ctaagaaatt atcaagtatt aacgatttga
    11761 ttgataataa tttcatgacc aaacacggaa atccaggtaa cggacgttat agaccagagg
    11821 attttagacc aaactcagct tacgtaaatg tcaatatgat ggcaggaatt tacggtggga
    11881 atacgagtca aggtgctcct ggttcattat cgttcaaaca taatgccttc cgtatgtggg
    11941 gttattatgg atatgacaaa ggtttcacta gttatgtatc tagcaaatat caaggtgaag
    12001 ctgataaaca aaaccagggt agattaggtg atgatttcat tatcaaaaaa gtttcaaaca
    12061 accaattctc aaatcttgaa gattggaaga aatattggta tcatgatgtg aaatccagag
    12121 ctgaaaaagg attcacagag attacaattg atggacaaac cattcacaac tataatgaac
    12181 tgaaagactt attcgacaaa gctgtcacag aagacctcaa gaaagctgga aactactcaa
    12241 atactgagaa tttgaaatcc aaagtcttca aagctcttct taaaaacaca gacggtttct
    12301 ttaatccatt gttcaaaaaa gacatttaaa ccccaattat tcacccc
//
LOCUS       DBERMM010000050        12304 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.052, whole genome shotgun sequence.
ACCESSION   DBERMM010000050 DBERMM010000000
VERSION     DBERMM010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12304)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12304)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12304
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.052"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(192..2450)
                     /locus_tag="ACL8AS_001809"
                     /pseudo
     CDS             complement(192..2450)
                     /locus_tag="ACL8AS_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398543.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
     gene            complement(2679..2909)
                     /locus_tag="ACL8AS_001810"
     CDS             complement(2679..2909)
                     /locus_tag="ACL8AS_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005592360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1797 family protein"
                     /protein_id="HGS1229620.1"
                     /translation="MESHLVRIINRLEAMANDGGNLKRNFEREGVVVAEVAYSHDEEN
                     GPIFTLRDVEDRETYTFDSIDLIAMEIYELLY"
     gene            3099..3782
                     /locus_tag="ACL8AS_001811"
     CDS             3099..3782
                     /locus_tag="ACL8AS_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001011621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HGS1229621.1"
                     /translation="MNFSFLPKYLPYFNYGAVVTILISICVIFLGTILGVVLAFGQRS
                     KFKPLVWLANLYVWIFRGTPMMVQIMIAFALMHINAPTIQIGILGVDFSRLIPGILII
                     SMNSGAYVSETVRAGINAVPKGQLEAAYSLGIRPKNAMRYVILPQAVKNILPALGNEF
                     ITIIKDSSLLSAIGVMELWNGATTVSTTTYLPLTPLLFAAFYYLIMTSILTVALKAFE
                     KHMGQGDKK"
     gene            3782..4516
                     /locus_tag="ACL8AS_001812"
     CDS             3782..4516
                     /locus_tag="ACL8AS_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HGS1229622.1"
                     /translation="MTETLIKIENLHKSFGKNEVLKGINLEIKRGEVVVIIGPSGSGK
                     STLLRSMNLLEEATKGKLIFEGVDITDKKNDLFAMREKMGMVFQQFNLFPNMTVMENI
                     TLSPIKTKGESREVAEKRAQELLEKVGLPDKADAYPQSLSGGQQQRIAIARGLAMEPD
                     VLLFDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAREVADRVIFMADGVV
                     VEDGTPEQIFEQTQEQRTKDFLSKVL"
     gene            4670..5527
                     /locus_tag="ACL8AS_001813"
     CDS             4670..5527
                     /locus_tag="ACL8AS_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000192112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="HGS1229623.1"
                     /translation="MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGDNP
                     ASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPK
                     HIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKN
                     AVVIGRSNIVGKPMAQLLLAKNATVTLAHSRTHNLAKVAAKADILVVAIGRAKFVTAD
                     FVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQ
                     AALRTLDRK"
     gene            5669..6541
                     /locus_tag="ACL8AS_001814"
     CDS             5669..6541
                     /locus_tag="ACL8AS_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000864675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-hydrate dehydratase"
                     /protein_id="HGS1229624.1"
                     /translation="MKVINQTLLEKVIIERSRSSHKGDYGRLLLLGGTYPYGGAIIMA
                     ALAAVKSGAGLVTVGTDRENIPALHSHLPESMAFSLQDQQLLKEQLEKAEVVLLGPGL
                     RDDASGENLVKQVFVNLSQNQILIVDGGALTILARTSLSFPSSQLILTPHQKEWEKLS
                     GITIEKQKEDATASVLTSFPQGTILVEKGPATRIWEVGQSDYYQLQVGGPYQATGGMG
                     DTLAGMIAGFVGQFRQASLYERVAVATHLHSAIAQELSQENYVVLPTEISRYLPKIMK
                     IICQQERVSKDKLV"
     gene            6823..7506
                     /gene="rpiA"
                     /locus_tag="ACL8AS_001815"
     CDS             6823..7506
                     /gene="rpiA"
                     /locus_tag="ACL8AS_001815"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004751 - ribose-5-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0009052 - pentose-phosphate shunt,
                     non-oxidative branch [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="HGS1229625.1"
                     /translation="MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEE
                     GLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALL
                     MEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREK
                     DGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGV
                     QISTSKKGK"
     gene            7520..8731
                     /locus_tag="ACL8AS_001816"
     CDS             7520..8731
                     /locus_tag="ACL8AS_001816"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019318858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0008973 - phosphopentomutase activity
                     [Evidence IEA];
                     GO_process: GO:0009117 - nucleotide metabolic process
                     [Evidence IEA];
                     GO_process: GO:0043094 - cellular metabolic compound
                     salvage [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HGS1229626.1"
                     /translation="MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISK
                     TVGLNVPNMAKIGLGNIPRETPLKTVAAEINPTGYATKLEEVSLGKDTMTGHWEIMGL
                     NITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIDDFGPRQMETGELII
                     YTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRT
                     ANRRDLAVSPFSPTVLDKLNEADIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTL
                     LKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMRENDLL
                     LITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETA
                     MIGESFLDKLV"
     gene            8733..9275
                     /locus_tag="ACL8AS_001817"
     CDS             8733..9275
                     /locus_tag="ACL8AS_001817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
                     /protein_id="HGS1229627.1"
                     /translation="MTRYALLVRGINVGSKNKVVMAELHQELTNLGLEKVESYINSGN
                     IFFASIDSKAQLVEKLETFFAVHYPFIQSFSLLSLEDFEAELENLPAWWSRDLARKDF
                     LFYTEGLDVDQVIATVESLELKDEVLYFGKLGIFWGKFSEESYSKTAYQKYLLKVPFY
                     RHITIRNAKTFDKIGQMLKK"
     gene            9291..10100
                     /locus_tag="ACL8AS_001818"
     CDS             9291..10100
                     /locus_tag="ACL8AS_001818"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004731 - purine-nucleoside phosphorylase
                     activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HGS1229628.1"
                     /translation="MTFLNKIHETATFLKEKGIAAPEFGLILGSGLGELAEEIENPVV
                     VDYAEIPNWGRSTVVGHAGKLVYGELAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKV
                     LGCEGVIVTNAAGGIRFGPGTLMAISDHINMTGQNPLMGENLDDFGPRFPDMSRAYTP
                     EYRATAHEVAKKLNIKIDEGVYIGVTGPTYETPAEIRSYKTLGADAVGMSTVPEVIVA
                     AHSGLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGDFKGLLKAILAEL"
     gene            10576..10971
                     /locus_tag="ACL8AS_001819"
     CDS             10576..10971
                     /locus_tag="ACL8AS_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipase family protein"
                     /protein_id="HGS1229629.1"
                     /translation="MLDSKEELKESENDAPKLETPLREEPRLAPQTLPEASEVLENKR
                     EESKVEITEPAQADDIRKVVGELAKDISITKLYMTGHSLGGYLAQIAAVEDYQKYPDF
                     YNHVLRKVTTFSAPKVITSRTVWDAKNGF"
     gene            10981..11556
                     /locus_tag="ACL8AS_001820"
     CDS             10981..11556
                     /locus_tag="ACL8AS_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000445853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
                     /protein_id="HGS1229630.1"
                     /translation="MESRKLAVSGKIKHYVVDNDNVVTPLIHNNRDIVTFTGNSRFKH
                     RSRGYFESPMNDIPNFNIGKQATLDKHGYRDPKLDKARFFKKQALPQSSSQPSAEPME
                     NIALGKQVTQSSTAFGGDARRAVDGKVDGNYGHNSVTHTNFQSKPWWQVDLAKEETIR
                     QINIYNRTDTAQDRLANFDVILLDGSGKEIE"
     gene            11581..12093
                     /locus_tag="ACL8AS_001821"
     CDS             11581..12093
                     /locus_tag="ACL8AS_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001275913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-activated cytolysin C-terminal
                     domain-containing protein"
                     /protein_id="HGS1229631.1"
                     /translation="MSAQITINHKKARYVRIELEGYNALSLAEVEVFRFIATNGETAI
                     QVSKSVQPISQTPVKDKTLTIQHSGAYIARYSITWEEVPVDKDGNQVVRSHSWEGNGR
                     NQTAGFVLNLPIKENMRNLRVKIEKKTGLLWNRWQTIYENRPILAQPHRKITHWGTTL
                     NSKVSDDDVL"
BASE COUNT         3650 a         2247 c         2786 g         3621 t
ORIGIN      
        1 ataagatgag aacaaatcga ttgggaaagt aaaattaatt tctataaatg ttttagcaat
       61 tgtttcgtac tatttcagat tcagtctact atatatcata atggacaaag ggcaagctgt
      121 caagaaatta cagttatttt agtaaaaaaa gaagcagaaa aatttcattt tctactcctt
      181 ttctatagga tttatttttc tttttcagaa cttttaactt cagctttttt ggcagattta
      241 atctgaatgt ttcccttgct agtcataact gctttgagat ctttttcgct tggattttca
      301 aggtagtagt cagtgattgt gtcctcaata tagtcttgaa tagtccgacg aagtgggcgt
      361 gctcccattt ttggatcata acctaggtca accaactttt ccttgacctt atcagttaca
      421 tccaaacgaa tgttgttgct agagaggcgc ttgttaacat ctgctagcat gagctcgaca
      481 atctgaagga ggttatcctt gctgagagcc ttaaattcga taatgccatc aaaacggttc
      541 ataaactctg ggctaaagaa gttaccgagt tcaccgagga cagaattggt acgtccttct
      601 ctagcagcac caaatccaac gctagcttcg gtctttcctg tacctgcatt tgaggtcatg
      661 ataatgatgg catccttgaa gctaacggtg cgtccttgcc cgtctgtcaa acgaccatcg
      721 tccaagactt gaagaaacat gtgcataaca tctgggtgag ctttttccac ttcatcgaga
      781 aggatgagag aatatggatt gtggcgaact ttttcagtta attgaccagc ctcatcatag
      841 ccaacataac ctggaggggc gccgaccaac ttagccacac tatgtttttc catgtattca
      901 ctcatatcaa agcgaatcat actatcagca gaaccaaaaa gttcgatagc cagttgtttg
      961 gaaagttctg tcttaccgac accagttggc ccaacgaaga ggaagcttcc gattgggcgg
     1021 ttaggggtac caagtccgac acgattacgg cgaatagcct tggcaatctt atcgactgca
     1081 tcatcttggc caataacatg agacttgaga tcttcggcta gatggatgag ttgagattgt
     1141 tctttctctt tcaaatcacc aacagggata ttggttttct gctcgataat gtgctcaata
     1201 gttttctagc tgatgatagg agtatcctgg tctgtgatct ttttcttttg catttcctta
     1261 tacttggcaa tctggtcgcg gaagtaggcc gccttctcaa aatcttcttc tcgtgtagct
     1321 tgagacttga gattttcagc ctcaatcaag cgctgatcaa ttactttagg atccacaaaa
     1381 ttcaaggtca agttcatctt agaaccagct tcatctagga ggtcaatggc cttgtcaggc
     1441 aagaagcgat cttggatgta gcgattggaa agagttgcag ctgcttcaat cgcagcatct
     1501 gtatattgaa cgtggtggta atcttcgtat ttcttttgaa tccctttgag aatagtgatt
     1561 gtttcgtcca ccgttggttc atcgacttta acaggctgca tacgacgctc gagggcagca
     1621 tccttttcaa tgatacggta ttcattgagg gtagtagcac cgactagttg cagttctcca
     1681 cgagcaaggg ctggcttgag gatatttcct gcgtccatat taccatcact cgcagaacca
     1741 gcaccaacaa tttcatggat ttcatcgata aagaggatga tgtcttcacg tttgcgaatt
     1801 tcttccatga gtttttgcat gcgttcttca aattgtcctc gaatccccgt tccttgaact
     1861 aagctaacca catccagacg gatgacttgt ttaccttgga gtttatgtgg cacatcgcca
     1921 tcgacaattt tctgagctag accttcgaca acggccgttt ttccgacacc aggttcaccg
     1981 ataaggacag gattattctt ggttctacga ttgagaatct cgatgacacg gataatctca
     2041 tcgtcgcgcc caataacggg gtcaatgtct ccacgacggg caatttcagt tacattaata
     2101 ccaaattctt ccagcaggcc tttttcttgg ctaggtggcg gagtttgagc agatccacga
     2161 ttttgggaac cataaccgcc gtttccaccg taacctccac ctgattgggt tgggggaata
     2221 ggaggagtat tgctagaagg tctgaaattg tttagatcat tgaagaaatc accaaaggga
     2281 tcgaagtcac gattgttcag atccgtcata cctttgaaga ggctattgtt aggatctgtt
     2341 ttgataatct tatagcagtt ttgacagagg tcaatttgtt tttgttttcc attgagattg
     2401 gtgtaaagat gaattgttga gtcgttaatt ttacagtttt gacaaagcat acatctacct
     2461 catttctttc tttagcctga cttgtttaaa ggtcaaaaat agtcaaattc tatactctca
     2521 ttataacagg attggggtgt aaagcaagta aaaagattga agctttgaga agttgttaca
     2581 atgaaaattt ttgtgaattt ggactataaa aaaatcctat ttgtgagaca aaaaggattt
     2641 tacttagaca tgcagggaca atcccagctt gttttagatt agtagagaag ttcgtaaatt
     2701 tccattgcga ttaagtcaat gctatcaaac gtatacgttt cgcgatcttc tacgtcacga
     2761 agggtaaaga ttgggccgtt ttcttcgtcg tggctgtacg caacttctgc aacaacaact
     2821 ccttcgcgtt caaaattacg ttttaaattt ccgccatcgt ttgccattgc ttcaaggcgg
     2881 ttgatgattc taaccaaatg tgattccatt ttgattctcc ttcatttctt atcgttacta
     2941 ttttaccata aaggaggcca acttgactag aaaaaactaa gatttctcgc taattctgct
     3001 agtttaaaga tttttaaata aattggataa aaaatttaaa ttttaattca aaacatgtta
     3061 taatcataca gtattctatt ttagaaagca gtgtgactat gaatttttct tttttaccta
     3121 agtatttacc ttattttaac tatggggctg ttgtgacgat tcttatttct atctgtgtta
     3181 tctttttggg aactattttg ggtgttgtct tggcttttgg gcaacgttca aagtttaaac
     3241 cgcttgtttg gttggccaac ttgtacgttt ggattttccg tgggacaccg atgatggttc
     3301 aaattatgat tgcctttgct cttatgcata tcaatgctcc gactattcag attggaattt
     3361 taggtgttga tttttcgcgt ctgattccag ggattttgat tatctctatg aatagtggtg
     3421 cttatgtttc ggagactgtt cgtgccggaa tcaatgcggt tccaaaaggt cagctagagg
     3481 cggcttattc gctagggatt cgtcctaaaa atgcgatgcg ttatgtgatt ttgccacaag
     3541 cagtcaaaaa tatcttgcca gcattgggga acgaatttat caccattatc aaggacagct
     3601 ccctcttatc agctattggg gtcatggagt tgtggaatgg ggctacaaca gtttctacaa
     3661 caacctatct acctttaaca ccacttttat ttgcagcatt ttactacttg attatgacct
     3721 ctattctgac agtagccttg aaagcttttg aaaaacatat gggacaagga gataagaaat
     3781 aatgacagaa accttgataa aaattgaaaa tttacataaa tcttttggaa agaatgaagt
     3841 attgaagggc atcaacctcg agattaaaag aggagaagtt gtcgttatca tcggtccttc
     3901 agggagtggg aaatctacct tgcttcgctc tatgaatttg ttggaggaag caaccaaggg
     3961 gaagcttatc tttgagggag tcgatattac ggacaagaag aatgacctgt ttgccatgcg
     4021 tgagaagatg ggcatggttt tccaacaatt taacctcttt cctaatatga ctgtgatgga
     4081 aaatattacc ttgtcaccta tcaagactaa aggtgaaagc agggaagttg ctgagaagag
     4141 agcccaagag cttttggaaa aagttggttt gccagataag gcagacgctt atccacagag
     4201 tctgtcgggt gggcaacaac aacggattgc catcgcgcgt gggttggcta tggaaccaga
     4261 tgttttgctc tttgacgaac caacttcagc cttggatcct gaaatggtag gtgaggtatt
     4321 ggctgttatg caagaccttg ccaagtcagg gatgactatg gttatcgtaa cacatgagat
     4381 gggatttgcc cgtgaggtgg cagatcgtgt tatctttatg gcagacggtg tggttgttga
     4441 agatgggaca cctgagcaga tttttgaaca aacccaagaa caacggacta aagatttctt
     4501 gagtaaggtt ttataatcta ttttaaaatt tcaagacaag attagtgaaa agttcaacca
     4561 gagctttttc ttatagtttg aaactatagg ataacctagg aaagaagtgt tagagggcac
     4621 tagcagtttt tggtataatg gaagatattt gaaagaaaag agaagtgata tgacacagat
     4681 tattgatggg aaagctttag cggccaaatt gcaggggcag ttggctgaaa agactgcaaa
     4741 attaaaggag gaaacagctc tagtgcctgg tttggtagtg attttggttg gggataatcc
     4801 agccagccaa gtctacgttc gcaacaagga gaggtcagct cttgcggctg gttcccgtag
     4861 cgaagtagtg cgagttccag agactattac tcaagaggaa ttgttagacc tgattgctaa
     4921 atataatcag gatccagctt ggcatgggat tttggtccag ttgccattac caaaacatat
     4981 cgatgaagag gcggttttat tagccattga cccagaaaag gatgtggatg gtttccatcc
     5041 cctaaacatg ggacgtcttt ggtctggaca tccagtcatg attccctcga cacctgcagg
     5101 aattatggaa atgtttcatg aatatgggat tgacttggaa ggtaaaaatg cggtcgtaat
     5161 cggtcgttca aatatcgttg gaaaacctat ggctcagctt cttttggcta aaaatgcgac
     5221 agtaaccttg gcccactcac gaactcataa tcttgccaag gtggctgcta aagcagatat
     5281 tcttgtagtc gcaatcggcc gcgccaagtt tgtgactgct gactttgtca aaccaggtgc
     5341 ggttgtcatt gacgttggga tgaatcgaga tgaaaatggg aagctctgtg gagatgttga
     5401 ttatgaggca gttgcaccac ttgctagcca tatcacgcca gtccctggag gtgtcggtcc
     5461 tatgaccatt accatgctga tggagcaaac ttatcaagca gcacttcgga cattggatag
     5521 aaaataagag aaacattcga ttaatagagt gtattttcta tagctatatc taaaatggca
     5581 gaaatgaata ttaaatttta gatataagat tacaaaagga ggtctgcgtc tcctttttat
     5641 tgtataataa aagtgagagg aaaaaaggat gaaagtgatt aatcaaacct tattagaaaa
     5701 agttattatt gaacgttctc gttcaagtca taaaggagat tatggtcgtc tgctgctgct
     5761 tggtggtact tatccttatg gaggtgccat catcatggct gctttagcag ctgtaaaaag
     5821 cggtgcagga ttggtgaccg ttggaacgga cagggaaaat atcccggctc tgcacagcca
     5881 tttacctgag tctatggcct tttctcttca agaccagcaa ttgttaaaag agcaattgga
     5941 gaaggcagaa gttgtcttgc tggggcctgg tttacgagac gatgcttctg gagaaaatct
     6001 agtaaaacag gtctttgtta atttaagcca aaatcagatt ttgattgtag acggaggtgc
     6061 cttgaccatt cttgctagga caagtttgtc atttccctca agccagctta tcctaactcc
     6121 tcaccaaaaa gaatgggaaa aattatctgg aattacgatt gaaaagcaaa aggaagatgc
     6181 aacggctagt gttctgactt ccttccctca aggaacaatt ttggtggaga aaggcccagc
     6241 tactcgtatt tgggaagttg gccaatctga ttattaccag ttacaggttg gtggtcctta
     6301 tcaggcgact gggggaatgg gagatactct ggctgggatg atcgcaggat ttgtaggcca
     6361 attccgacag gccagtctct acgagcgtgt ggcagtagcg acccatcttc attcagccat
     6421 agcccaagaa ctatctcaag aaaattatgt ggtcttaccg acggaaatca gcaggtatct
     6481 tcccaaaata atgaaaatta tttgtcaaca agagagggta agcaaagata aacttgttta
     6541 aaatagacag ataaatctac ttccttctct taatttatga ttcttgaaat gcgcctgctt
     6601 taaggctaaa ctagacgtat caaagttaag agtttgtttt tgtaactgga aagagatgaa
     6661 caaatcaaat acataaaaga taaactcatt tttattcgtt tggtaaaaat aaaatgcata
     6721 tttttaaaga aagattgatg aaaaatgtag atttgatgtt tttacttgaa taaaaagcgg
     6781 tttcatagta aaataagaat tgagaatgat ggaggtaaat cggtggaaaa tctgaagaaa
     6841 atggcaggta tcaaggctgc tgagttcgtg agcgatggaa tggtcgttgg acttggaaca
     6901 ggctcgactg cctattattt tgtcgaagaa atcggtcgtc gtatcaagga agaaggattg
     6961 cagattacag ctgtaacaac ttctagtgtg accactaaac aggcagaagg ccttaatatc
     7021 ccgctcaagt ctattgacca agtagacttt gtcgatgtga cggttgatgg cgcagatgaa
     7081 gtggatagtc agtttaatgg aatcaaaggc ggtggtggtg cccttctcat ggaaaaggtg
     7141 gtcgcaacac catcaaaaga atacatttgg gtggtggatg aaagcaagct ggtcgaaaaa
     7201 ctaggtgctt ttaaattgcc agtagaagtg gttcagtatg gtgcagagca ggtctttcgt
     7261 cattttgaac gagctggcta caaaccaagt ttccgtgaaa aagacggcca acgttttgtg
     7321 acggatatgc agaattttat cattgacctc gccttggatg tcattgaaaa tccaattgct
     7381 tttggacaag aattggacca tgtcgttggt gttgtggagc atggtttatt caaccaaatg
     7441 gtggataagg taatcgttgc tggacgagat ggagttcaga tttcaacttc aaaaaaagga
     7501 aaatagaagg gggcataaga tgtctaaatt taatcgtatt catttggtgg tactggattc
     7561 tgtaggaatc ggtgcagcac cagatgctaa taactttgtc aatgcagggg ttccagatgg
     7621 agcttctgac acactgggac acatttcaaa aacagttggt ttgaatgtcc caaacatggc
     7681 taaaataggt cttggaaata ttcctcgtga aactcctctt aagactgtag cagctgaaat
     7741 caatccaact ggatatgcaa caaaattaga ggaagtatct cttggtaagg atactatgac
     7801 tggacactgg gaaatcatgg gactcaacat tactgagcct ttcgatactt tctggaacgg
     7861 attcccagaa gaaatcctga caaaaattga agaattctca ggacgcaagg ttattcgtga
     7921 agccaacaaa ccttattcag gaacggctgt tatcgatgat tttggaccac gtcagatgga
     7981 aactggagag ttgattatct atacttcagc tgaccctgtt ttgcagattg ctgcccacga
     8041 agacattatt cctttggatg aattgtaccg tatctgtgaa tacgctcgtt cgattaccct
     8101 tgagcgtcct gcccttcttg gtcgcatcat tgctcgccct tatgtaggtg aaccaggtaa
     8161 cttcactcgt acggcaaacc gtcgtgactt ggctgtatct ccattttccc caactgtttt
     8221 ggataaattg aatgaggctg atatcgatac ttatgctgtg ggtaaaatca acgatatctt
     8281 taacggtgct ggtatcaacc atgacatggg tcacaacaag tcaaatagtc atggaattga
     8341 tacactattg aagactatgg gacttgctga gtttgaaaaa ggattctcat tcacaaacct
     8401 agttgacttt gatgcccttt acggccatcg tcgtaatgct cacggttacc gtgattgctt
     8461 gcatgagttt gatgaacgct tacctgaaat tatcgcagct atgagagaga atgaccttct
     8521 cttgattact gcggaccatg gaaatgaccc aacgtatgca ggaacggatc acactcggga
     8581 atatattcca ttgttggcct atagccctgc ctttaaagga aatggtctca ttccagtagg
     8641 acattttgca gatatttcag cgactgttgc cgataacttt ggtgtggaaa ctgctatgat
     8701 tggggaaagt ttcttagata aattggtata agatgacgcg ctatgctttg ctggtgagag
     8761 gtatcaatgt tggtagtaag aataaggtcg tcatggcgga gcttcatcaa gaattgacaa
     8821 acttgggact ggaaaaggtt gagagctaca tcaacagtgg caatattttc tttgcttcga
     8881 tagattccaa agcccaattg gttgaaaagc tagagacttt ctttgcagtc cattatccat
     8941 ttattcagag cttttcttta ctgagtctag aggactttga ggcggaactt gaaaatctac
     9001 cagcttggtg gagcagagac ttggcacgaa aagattttct cttttacact gagggtttgg
     9061 atgtggacca agtcatcgcg acagttgaaa gtttagagct gaaagatgaa gtgctttatt
     9121 ttggaaaact tgggattttc tgggggaaat tttctgaaga atcctattct aagactgcct
     9181 atcagaagta cttgctgaag gtgcctttct accgccacat tactattcgt aatgctaaaa
     9241 cctttgacaa aattggtcaa atgctaaaaa aataataaag gagacacaca atgacatttt
     9301 taaacaaaat ccatgaaact gctactttcc tgaaagaaaa gggaattgca gcccctgagt
     9361 tcggtctaat ccttgggtca ggacttggag aattggcaga agaaatcgaa aatccagttg
     9421 tagtagacta tgctgagatt ccaaactggg gccgttcaac agtagtcggt catgctggta
     9481 aattggtata tggtgaactg gcaggtcgca aggtcttggc tcttcaaggg cgtttccatt
     9541 tctatgaagg gaatcctctg gaagtggtga ctttcccagt tcgtgtgatg aaagttcttg
     9601 gatgtgaagg tgttattgta accaatgcag ctggcggtat cagatttggt cctggtacct
     9661 tgatggctat ctcagaccat atcaacatga cggggcaaaa tccattgatg ggggaaaact
     9721 tggatgactt tggcccacgt ttcccagata tgtctagggc ctacacacca gaataccgtg
     9781 ccactgccca tgaagtggct aaaaaactta atatcaagat tgatgaaggt gtctatatcg
     9841 gagttactgg tccgacttat gaaacaccag cagaaattcg ttcctataag acactgggag
     9901 cagatgcagt tggtatgtct acggttcctg aagttatcgt ggcagcccac tctggcttga
     9961 aagttctggg aatttcatgt atcactaact ttgcggctgg tttccaagaa gaactcaatc
    10021 acgaagaagt tgtagaagtg actgaacgtg ttaaaggtga tttcaaaggc ttgcttaaag
    10081 cgattcttgc tgaattgtaa gaaaaaagat ttaaaagggg gagtgcctct gtcttttcag
    10141 gattgactgc ctatccgtat taaagaagaa acagaggaat actatgagct tcttcctgct
    10201 cttataactg aaagaagcgg aagaataggt gtgtctgatc tgatagccag cattgtgaaa
    10261 gacaagattc taggatacta gcattagctt cctagccaag cagactagta tgataaggag
    10321 agatgagaat gaattgactt tctgaatttc tcagtcttat catatatagc acaatgagat
    10381 ttcgcttgag tctgcttgta aataaacgaa aagaaagata agaaataatg aaaattggtc
    10441 aacgaattat gcgctttggc ataaaaaatt aagtatcgga gttgtatctg ttgtagtcgg
    10501 ctttgatttc tagctccagc tggaatttca gccaatgaag taaagcaaga tgtaacatct
    10561 gaagtggtaa taggtgtgct agattctaag gaggaattga aagagtcaga aaatgatgct
    10621 ccaaaactag aaactcctct tagagaggag ccaagactag ctcctcaaac gcttccggaa
    10681 gcaagtgaag ttcttgaaaa caaaagggaa gagtcaaaag tagagataac agagccagct
    10741 caagcggatg atatccgcaa ggttgttggg gaattagcca aggatataag tattactaag
    10801 ttgtatatga caggtcattc tcttggaggc tacctagctc agattgcagc ggttgaagat
    10861 taccaaaaat atcctgattt ttataaccat gtattgagga aagtgacaac tttcagtgct
    10921 cctaaagtga ttacttccag aactgtttgg gatgctaaga atggtttctg agatgttggt
    10981 ttggaaagtc gtaaattagc tgttagtgga aaaattaagc attatgtggt tgataatgac
    11041 aatgttgtga ctcccttgat tcataataat cgtgatattg ttacatttac aggtaattca
    11101 cgctttaaac accgttctcg tggctatttt gaaagtccaa tgaatgatat tcctaacttt
    11161 aatattggta aacaagctac cttggataaa catggttatc gtgatccgaa attggataaa
    11221 gcgcgattct ttaagaaaca ggctctacct caatcttcta gtcaaccaag cgctgaacca
    11281 atggaaaata ttgccttagg aaaacaggtt actcaaagtt cgacagcttt cggaggagat
    11341 gctagaagag ctgtggatgg caaagtcgat ggtaactatg gtcacaattc tgtcactcat
    11401 acaaacttcc aatctaagcc ttggtggcaa gtagatttgg ctaaagaaga aaccattcgc
    11461 caaatcaata tttacaaccg aacagacact gcccaggata gattggcaaa ctttgatgtc
    11521 attcttttag acggttctgg taaagaaatt gagtgaaaac gtataatatc tcctaaagat
    11581 gtgtcagcac aaattacgat taaccataaa aaagcgcgct atgttcggat tgagctagaa
    11641 ggctataatg ccctcagtct tgcagaagtt gaagttttcc gctttatagc tacgaatggt
    11701 gaaacggcga tacaagtttc taagtcagtt caaccaatca gtcagactcc tgtgaaagat
    11761 aaaacattga caattcaaca cagtggagct tacattgccc gctactccat aacttgggaa
    11821 gaagttccag tagataaaga tggaaaccaa gttgttcgta gtcattcttg ggaaggaaac
    11881 ggtcgcaacc agactgcagg ttttgtcctc aacctcccaa tcaaagaaaa tatgagaaat
    11941 ctgcgagtta agattgagaa aaagacgggc ctactatgga atagatggca aacaatctat
    12001 gaaaacagac caattttagc tcaaccccac cgtaaaatta cccattgggg tacgacattg
    12061 aattccaagg tgagtgacga tgatgtcttg taatctgatg gtacaatgac agttagtttg
    12121 tctagtttat aagaaagtac tacctgagct tgaatagaac tcaggtagct ctctgtgaaa
    12181 gaacaaaatt aatactcaat gaaaatcaaa gagcaaacta agaaactagc cgcaggttgc
    12241 tcaaagcact gctttgaggt tgtagataag actgacgaag tcagtcacat atataatcca
    12301 aggc
//
LOCUS       DBERMM010000051        11658 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.053, whole genome shotgun sequence.
ACCESSION   DBERMM010000051 DBERMM010000000
VERSION     DBERMM010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11658)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11658)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11658
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.053"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            200..454
                     /gene="blpM"
                     /locus_tag="ACL8AS_001822"
     CDS             200..454
                     /gene="blpM"
                     /locus_tag="ACL8AS_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpM"
                     /protein_id="HGS1229632.1"
                     /translation="MDTKIMEQFHEMDITMLSSIEGGKNNWQTNVLEGGGAAFGGWGL
                     GTAICAASGVGAPFMGACGYIGAKFGVDLWAGVTGATGGF"
     gene            470..673
                     /gene="blpN"
                     /locus_tag="ACL8AS_001823"
     CDS             470..673
                     /gene="blpN"
                     /locus_tag="ACL8AS_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpN"
                     /protein_id="HGS1229633.1"
                     /translation="MNTYCNINETMLSEVYGGNSGGAAVVAALGCAAGGVKYGRLLGP
                     WGAAIGGIGGAVVCGYLAYTATS"
     gene            917..1066
                     /gene="blpO"
                     /locus_tag="ACL8AS_001824"
     CDS             917..1066
                     /gene="blpO"
                     /locus_tag="ACL8AS_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="HGS1229634.1"
                     /translation="MDTKMMSQFAVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDG
                     CATTV"
     gene            1170..1289
                     /locus_tag="ACL8AS_001825"
     CDS             1170..1289
                     /locus_tag="ACL8AS_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="HGS1229635.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKIFSKSSKKDTDSTL"
     gene            2075..2458
                     /locus_tag="ACL8AS_001826"
     CDS             2075..2458
                     /locus_tag="ACL8AS_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HGS1229636.1"
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGV
                     FLLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHI
                     FIVFNALMYLLSSSQVSLKKNKLSS"
     gene            2510..3199
                     /locus_tag="ACL8AS_001827"
     CDS             2510..3199
                     /locus_tag="ACL8AS_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysostaphin resistance A-like protein"
                     /protein_id="HGS1229637.1"
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNLF
                     WIQNILSLLFIGVMIVVLVKTGHGYLFRIPRKKWLWYSILTVLVVVLQISFNVQTAKH
                     VQSTAEGWAVLIGYSGTNFAELGIYIALFFLVPLMEELIYRGLLQHAFFKHSRFGLDL
                     LLPSILFALPHFLSLPSLLDIFVFATFGIIFAGLTRYTKSIYPSYAVHVINNIVATFP
                     FLLTFLHRVLG"
     gene            3241..3489
                     /gene="blpZ"
                     /locus_tag="ACL8AS_001828"
     CDS             3241..3489
                     /gene="blpZ"
                     /locus_tag="ACL8AS_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein BlpZ"
                     /protein_id="HGS1229638.1"
                     /translation="MYKHLFFLDSKTLDRLTPYILVLASDTIAFNVFVLTFVSAVVFN
                     FLNSMLALMAIFIGAGYVVGFWLLKWFVLERLELKNDV"
     gene            3519..4130
                     /locus_tag="ACL8AS_001829"
     CDS             3519..4130
                     /locus_tag="ACL8AS_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="HGS1229639.1"
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALIIVSL
                     LVTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHL
                     AEVSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSN
                     VPSFIFYLLGGLLLGFAYKKSQNLWVSTLVHMLYNSWPLLYYL"
     gene            4291..5085
                     /gene="ccrZ"
                     /locus_tag="ACL8AS_001830"
     CDS             4291..5085
                     /gene="ccrZ"
                     /locus_tag="ACL8AS_001830"
                     /EC_number="2.7.1.15"
                     /EC_number="2.7.1.229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004747 - ribokinase activity [Evidence
                     IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_function: GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA];
                     GO_process: GO:0051726 - regulation of cell cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell cycle regulator CcrZ"
                     /protein_id="HGS1229640.1"
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGL
                     AREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQ
                     LSRLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDV
                     RHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTV
                     LSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            5082..5717
                     /gene="trmB"
                     /locus_tag="ACL8AS_001831"
     CDS             5082..5717
                     /gene="trmB"
                     /locus_tag="ACL8AS_001831"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008176 - tRNA
                     (guanine(46)-N7)-methyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HGS1229641.1"
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVE
                     VGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEAGVSNIKLLWVDGSDLTD
                     YFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFE
                     YSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            5843..6322
                     /gene="rimP"
                     /locus_tag="ACL8AS_001832"
     CDS             5843..6322
                     /gene="rimP"
                     /locus_tag="ACL8AS_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0042274 - ribosomal small subunit
                     biogenesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HGS1229642.1"
                     /translation="MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVD
                     KPEGITLNDTADLTEIISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGK
                     YIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL"
     gene            6366..7502
                     /gene="nusA"
                     /locus_tag="ACL8AS_001833"
     CDS             6366..7502
                     /gene="nusA"
                     /locus_tag="ACL8AS_001833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_process: GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination factor NusA"
                     /protein_id="HGS1229643.1"
                     /translation="MSKEMLEAFRILEEDKGIKKEDIIDAVVESLRSAYRRRYGQSDS
                     VAIDFNEKTGDFTVYTVREVVDEVFDSRLEISLKDALAINSAYELGDKIKFEEAPAEF
                     GRVAAQSAKQTIMEKMRKQTRAITYNTYKEHEQEIMSGTVERFDNRFIYVNLGSIEAQ
                     LSKQDQIPGEVFASHDRIEVYVYKVEDNPRGVNVFVSRSHPEMIKRLMEQEIPEVYDG
                     TVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRGGANIKKITSKFHPARYDAKNDR
                     MVPIEENIDVIEWVADPAEFIYNAIAPAEVDQVIFDENDSKRALVVVPDNKLSLAIGR
                     RGQNVRLAAHLTGYRIDIKSASEFEAMEDAASVELEVENDTVEE"
     gene            7524..7817
                     /locus_tag="ACL8AS_001834"
     CDS             7524..7817
                     /locus_tag="ACL8AS_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HGS1229644.1"
                     /translation="MKTRKIPLRKSVVSNEVIDKRDLLRIVKNKEGQVFIDPTGKANG
                     RGAYIKLDNAEALEAKKKKVFNRSFSMEVEESFYDELIAYVDHKVKRRELGLE"
     gene            7810..8109
                     /locus_tag="ACL8AS_001835"
     CDS             7810..8109
                     /locus_tag="ACL8AS_001835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxQ-related RNA-binding protein"
                     /protein_id="HGS1229645.1"
                     /translation="MNKQKMSNLLGLAQRAGRIISGEELVVKAIQDGKAKLVFLAHDA
                     GPNLTKKIQDKSHYYQVEIVTVFSTLELSIAVGKSRKVLAVTDAGFTKKMRSLME"
     gene            8126..10918
                     /gene="infB"
                     /locus_tag="ACL8AS_001836"
     CDS             8126..10918
                     /gene="infB"
                     /locus_tag="ACL8AS_001836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003743 - translation initiation factor
                     activity [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HGS1229646.1"
                     /translation="MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAA
                     KIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVA
                     AKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNR
                     RFNDQAKKEQGQQKRRNERRQQEDKRSNQVAPRIDFKARAAALKAEQNAEYARSSEER
                     FKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKK
                     QARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTP
                     KPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGET
                     IELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTL
                     LDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDIT
                     ILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTA
                     WGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAV
                     ATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGD
                     HFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADV
                     QGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQAR
                     QQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIG
                     GFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDI
                     KMDDVIEAYVMEEIKR"
     gene            11169..11519
                     /gene="rbfA"
                     /locus_tag="ACL8AS_001837"
     CDS             11169..11519
                     /gene="rbfA"
                     /locus_tag="ACL8AS_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HGS1229647.1"
                     /translation="MANHFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGD
                     LSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEY
                     GNKIDEMLRNLDKN"
BASE COUNT         3576 a         2031 c         2642 g         3409 t
ORIGIN      
        1 tacgaatgaa tttgagtgct ggtattatca atcatgaact aggattctag ttttgcagga
       61 agtctaatgt aatttttgca attcaagacg tttcgatgac tattcaagat ctggatgaaa
      121 aattttaaaa aacgatgata tactaaactt gtcaaagtta caacaagaca aaaattaaaa
      181 ataaaaaaga gtatttgtca tggatacaaa aattatggaa caatttcatg aaatggatat
      241 aactatgtta tctagtattg aaggaggcaa gaataattgg caaactaatg tcttagaagg
      301 tggtggtgct gcttttggtg gctgggggct agggacagct atttgtgctg cgagtggtgt
      361 tggagcacca tttatgggag catgtggata cataggagct aaatttggtg tggatctttg
      421 ggcaggagta acaggggcaa cgggtggatt ttaataaaag gagacttgta tgaatactta
      481 ttgtaatata aatgaaacaa tgctgagtga ggtttatgga ggtaattccg gaggagcagc
      541 tgtagttgct gctttaggtt gtgcagcggg tggagtgaaa tatgggagac ttctaggacc
      601 atggggcgct gcaataggag gaattggagg agcagtggtt tgtggatatt tagcctatac
      661 cgctacatca taaaaatgaa agctaaattt tatgaaggct atattcttta ttattctctt
      721 cgcttttcaa acctatctta tttatctatc cataagtatc tccgataaaa aacaaaagac
      781 tattgaatta acatcattga attgttttgt catattattt ctaatctatg ataaattaat
      841 ttttctcttt attgcctatg tttttttgat aatttttata ttaaacttgt tccgtaactg
      901 aaaagtgata tactatatgg atacaaaaat gatgtcacaa tttgcagtta tggataatga
      961 aatgcttgct tgcgttgaag gtggagatat tgattgggga agaaaaatta gttgtgcagc
     1021 aggggttgca tatggcgcaa ttgatgggtg tgcaacaacg gtttgacatt tctattggga
     1081 ccatttgcta taggaatagg tgtaactggt gctgcaggtg gagctatact tggaggtgta
     1141 gcctatgcag caatatgttg gtggtaatta tggattttaa aagttttatt attggtttag
     1201 tagttggtat atttggtcct tatatggatg acttaattag aaaaatattt tcaaaatctt
     1261 ccaaaaagga tacggatagt actctctaaa aaataaattt ctcccctgta tttgctagct
     1321 taatttacag gggagtttct ttaatattgt ttcgcctgtc aaaatgatat gtgatagcag
     1381 gatgaaaagt ctacaaacaa gttggtatca atacaatata aagaggaaag tatgttttta
     1441 atgcttactt tttaaatttt ttaacaattc aagatgtttc gatgacaatt caagatttgg
     1501 atgaaaaatt ttaaaaaaca atgatatact aaacttgtca aagttgcaac gggtgctgct
     1561 acattatgtt aaaaatcgct cttgattgat aagttggatt tgttaggaaa ggagtaaata
     1621 attatggata agaaaaagat agtttcgact ataatatgta tagtatttct tgtagtgtca
     1681 gtagataatt tttttagaga cttaaccccg ttactgttca ttttaaatat tattggcctg
     1741 tcttgctttt cagtgctaac atacattaac ataaaagaga tactcttaaa tataagtaaa
     1801 tgatgatttg gttagtccta gaaccaatca acttatgttt atcggcttgg cagattttat
     1861 gtttgtcatt tgtttgtata gaggtatttc agaaacagaa ttctatcaac aactaatcgc
     1921 ttatataggt gtattctctg cttgtttatc acgcttctgc tcatgtgggg cttgaagtat
     1981 tataaaaagt agctttctat ccttttctga caggatattt gagtagaagg ctctattaaa
     2041 ttgttagtga aataaatgaa tggaggtatt taatatgaaa tacagattat tttttgttat
     2101 tttcttgagt agtgtgttgg atattctttt agggacattt ttacaaatct ctatcgtatc
     2161 tattgggtgg cttgttcttt acagtggttt gtttgaagca ggagttttcc ttcttgctaa
     2221 taaaggggtg gcggtaaaaa tcaaggaagt agatattcga aatcgcttta aatttatttt
     2281 tggaaaaacc ttatggtttc aaattctttt gctcatcttt ttgataatca aactttatct
     2341 tggtttggat gcgaggttga ttttattcta tggacatatt ttcattgtct ttaatgcctt
     2401 aatgtatcta ttatctagta gtcaggttag ccttaaaaaa aacaaactgt cttcttaatc
     2461 ttacagcagt agagcctgac aaggtgaggt catagtaggg aggatttcta tgaaaaagta
     2521 tcaacttcta ttcaaaataa gtgcagtctt ctcttactta tttttcgtat ttggtctttc
     2581 tcagctgacg cttatcgtcc aaaactattg gcaattttct tctcagatag gcaatttatt
     2641 ctggattcaa aatatcttga gtttactttt tattggagtc atgattgtgg ttcttgttaa
     2701 gacaggccat ggttatctct tccgcattcc aagaaaaaaa tggctttggt attcgatttt
     2761 gacagtatta gtggtagtgt tacagatctc ttttaacgtt cagacagcta aacatgttca
     2821 gtcaactgcg gaaggttggg ctgtattgat tggttatagt gggactaact ttgcagagct
     2881 aggtatttat atagccctgt tctttctggt tccactgatg gaagaattga tttatagagg
     2941 attactgcaa catgctttct ttaagcattc gcgatttggc cttgatttgc ttcttccttc
     3001 cattttgttt gctcttcctc attttttgag tctgcctagt ctgttagata tcttcgtctt
     3061 tgcaacattt ggaatcatct ttgccggttt gacccgctat accaagagta tttatccatc
     3121 ctatgcggtg catgtgatca ataatattgt agcgaccttc ccgtttttgc tcacttttct
     3181 acatagggtc ttggggtaaa aaaacaaaag gcttgctttt cagccataga ggaggtcatc
     3241 atgtataaac acttattttt cctagattcc aaaactttag atcggttgac accctatatt
     3301 ctagtcttgg cttctgacac cattgctttt aatgtttttg tgctaacctt tgtatctgcg
     3361 gtggttttta atttcctaaa ttccatgcta gctttaatgg ctatattcat aggggctggc
     3421 tatgtggtcg gattttggtt gctaaaatgg tttgttttgg aaaggctaga actaaagaat
     3481 gacgtgtagg aagtctgttt gttgaggagg ataattttat ggagtttttt gataaatttc
     3541 atgccttgtg ttttggattt ttagtactaa taattgtcat tacagttcct tatacgatta
     3601 accatgggga tttttttcaa aatgaatctg cattgattat tgtaagtctt cttgtaacct
     3661 cgctgagtgt tgcttatgct agaaagtttg aaatgatttc ttttgggatg ttaagcaaga
     3721 aacaactttt gcttttcatt gcaatctttc ttctaagtgt acttgagacg ctggtttata
     3781 ttcatttctt cgctgtttct tctggctcag gggtccaaca cttggcggaa gtcagcagag
     3841 gaatttccct gtctttgatt ttaactacct cagtttttgg ccccatccag gaggaactca
     3901 ttttcagagg acttcttcaa ggtgcggttt ttgacaattc ttggttaggg cttgtgctaa
     3961 cttcctctct cttttctttc atgcatggac cttctaatgt cccttcgttt attttttatc
     4021 tacttggggg tttgttgctg ggctttgctt ataaaaagag tcaaaaccta tgggtttcta
     4081 ctctagtcca tatgctttac aacagttggc cactcttata ttatttataa aaattatgaa
     4141 aaggtaagca gaagacggtg cttacctttt tcaagctata atgataccca agccaatcca
     4201 gaggcttttc tttgagaatc gggttagagt ggttgacgaa taggccaaaa actagtagaa
     4261 tagtaaggaa actttatacg gaggaaagaa atggatttgg gtgataatga gctaacactg
     4321 actcccatac ctgggaaaag tggcaaggct tatatgggta gctatcctga tgggaagcgc
     4381 atctttgtaa aaatgaacac ctctccaatc ctacctggtc tagctagaga acaaattgct
     4441 ccacaattat tatggagtcg tcgtttggca gatgggcgtg atatgtgtgc tcaagaatgg
     4501 ttgacaggca agatattgac cccctatgat atgaatcgta agcaaatcgt caatatttta
     4561 acccgtcttc atcgctcacg tccgttgatg acacaattga gtcgtttggg ctatgccatg
     4621 gaaacacctg tagatttact acagtcttgg caggaaacgg ctccagatgc tttgcgtaaa
     4681 aatcatttta tcagtgaagt gatggctgat ttacgtcaga ctattccagg atttagagag
     4741 gaccatgcga ccattgtcca tggagatgta cgacatagta attggattga gacagatagt
     4801 ggcttgattt atttagtaga ttgggattcg gttcgcttga ccgatcgcat gtttgatgtg
     4861 gcccatatgc tctgccatta tatttcagaa catcagtgga aggaatggtt gacctactac
     4921 ggttacaagt acaatcaaac ggtattaagt aaattgtatt ggtatggtca attgtcttat
     4981 ttgagtcaga tttccaagta ttatatgaac caagatttag aaaatgtcaa tcgggagatt
     5041 catggtttgc gtcatttccg agacaagtat ggaaagagaa gatgagagtt agaaatcgta
     5101 aaggggcaac agaattacta gaggcaaatc cccagtatgt ggtcctcaat cccttggaag
     5161 ccaaggcaaa atggcgggac ttgtttggca atgataatcc cattcatgtg gaagttggaa
     5221 gtggaaaggg tgcctttgtt tcaggtatgg ccaagcaaaa ccctgacatc aactatatcg
     5281 ggattgatat tcaaaagtct gttttgagct acgctttgga caaggtgctt gaagctggag
     5341 tgtctaacat caagctcttg tgggtagatg gttctgactt gactgactac tttgaagacg
     5401 gtgagattga tcgcttgtat ctgaactttt cagatccatg gccgaaaaaa cgccatgaaa
     5461 agcgtcgttt gacctacaag acctttttgg ataccttcaa acgtatcttg cctgaaaatg
     5521 gagaaattca tttcaagacg gataaccgtg gcttgtttga gtacagttta gtgagctttt
     5581 ctcaatatgg catgaaactc aatggtgtct ggctagattt gcatgccagt gattttgaag
     5641 gcaatgtcat gacagaatac gagcaaaaat tctcaaacaa ggggcaagtt atctaccgag
     5701 ttgaggcaga attttaagag atagcctaaa attaggctgt acaagtgctt ttgctttaca
     5761 taagttggca aacgtgctat actgatagta agaatatgaa aagtgaggcg gggaaatatc
     5821 ttcgcctctt gcttatgagg aggtggacgc aatcgcaaca atcgtagaat tagtcagaga
     5881 agttgtagaa cctgtcatag aagctccttt tgaactcgtg gatatcgagt atggaaagat
     5941 tggcagtgac atgattctca gtatttttgt agataaaccc gaaggaatta ccttgaacga
     6001 cacggcagac ttgacagaaa ttatcagtcc tgtcctagac accatcaagc cagatccctt
     6061 cccagaacaa tatttcctag aaattaccag tccaggtttg gaacgtcctt tgaaaaccaa
     6121 ggatgccgtc gctggagcgg ttggaaaata catccatgtc gggctctacc aagccatcga
     6181 taagcaaaag gtctttgaag gaaccttgtt ggccttcgaa gaggacgagt tgactatgga
     6241 atatatggac aagacgcgta agaaaaccgt ccaaattcca tacagtttag tatcaaaagc
     6301 acgtttagca gttaaattat agaaaaagaa aggatagctt ttgaggattc aaaagtgaag
     6361 aaaacatgag taaagaaatg ctagaggcct tccgcatttt ggaagaagac aagggaatca
     6421 aaaaagaaga tatcatcgac gcagtagtag agtcgcttcg ttccgcttat cgcagacgct
     6481 atggtcagtc agacagcgta gctattgact tcaacgaaaa aacaggtgac tttacagttt
     6541 atactgtccg tgaagttgtt gatgaagtat ttgatagccg tttggaaatc agcttgaaag
     6601 atgctcttgc cattaattca gcttatgaac ttggagacaa aatcaagttt gaagaagcac
     6661 cagctgagtt tggtcgtgta gcagcccaat ctgccaaaca aaccatcatg gaaaaaatgc
     6721 gcaagcaaac acgtgccatc acttacaata cttacaaaga acatgagcaa gaaatcatgt
     6781 ctggtacagt agaacgcttt gacaaccgct ttatctatgt caaccttggt agcatcgaag
     6841 cccaattgtc aaaacaagac caaattcctg gagaagtttt tgcttctcat gatcgtatcg
     6901 aagtttatgt ttacaaggtt gaagacaacc ctcgtggtgt gaacgtcttt gttagccgta
     6961 gccatccaga aatgatcaaa cgtttaatgg agcaagaaat tccagaagtt tatgatggaa
     7021 ctgttgaaat catgagcgtg gctcgtgaag caggtgaccg tacgaaggtt gctgttcgta
     7081 gccacaatcc aaacgtggat gctatcggta caatcgttgg acgtggtggt gctaatatca
     7141 agaagattac tagcaaattc cacccagctc gttacgatgc taaaaatgac cgcatggtac
     7201 caatcgaaga aaatatcgat gttatcgagt gggtagcaga tccagctgaa tttatctaca
     7261 atgccatcgc tcctgctgag gttgaccaag ttatctttga tgaaaacgac agcaaacgtg
     7321 ccttggtggt tgttccagat aacaagcttt ctcttgccat tggtcgtcgt ggacaaaacg
     7381 tgcgcttggc ggctcacttg actggttacc gtatcgatat caagtctgct agcgaatttg
     7441 aagccatgga agacgctgct tcagtagagt tggaagtaga aaacgatact gtagaagaat
     7501 aaaagctgct agaggaggga aagatgaaaa caagaaaaat ccctttgcgc aagtctgttg
     7561 tgtctaacga agtgattgat aagcgtgatt tgctccgcat tgtcaagaac aaggaaggac
     7621 aagtctttat tgatcctacg ggcaaggcca atggccgcgg cgcttatatc aaactagaca
     7681 atgcagaagc cctagaggcg aaaaagaaga aggtctttaa ccgcagcttt agcatggaag
     7741 tggaagaaag cttttatgac gagttgatcg cttatgtgga tcacaaagtg aaaagaagag
     7801 agttgggact tgaataagca aaagatgagt aatctcttgg ggcttgctca gcgagcaggg
     7861 cgcatcatat cgggtgaaga attggtggtc aaggccattc aagacggcaa ggccaagttg
     7921 gtctttctag ctcatgatgc tggacccaat ctgaccaaga agattcaaga taaaagtcat
     7981 tattatcaag tagaaattgt aaccgtgttt tcaacactgg aattaagcat agcagtcggg
     8041 aaatcgagaa aggttttggc tgtaacagat gctggattta caaagaaaat gaggtctctt
     8101 atggaataga agaggaggac atgatttgtc taagaaaaga ttgtacgaaa tcgcaaaaga
     8161 acttggaaaa gaaagtaaag aagttgtagc gcgtgcaaaa gagttgggct tggatgtgaa
     8221 aagccactca tcaagtgtgg aagaagctgt cgctgcaaaa attgctgcca gctttaagcc
     8281 tgcagctgct ccgaaagtag aagcaaaacc tgcagcacca aaagtaagtg cagaaaagaa
     8341 agccgaaaaa tctgagccag ctaaaccagc tgtagctaag gaagaggcaa aaccggctga
     8401 gccagttgct ccgaaaacag aaaaagtagc agcgaaaccg caaagccgta atttcaaggc
     8461 tgagcgtgaa gcccgtgcta aagagcaggc agaacgacgc aagcaaaata agggcaataa
     8521 ccgtgaccaa caacaaaacg gaaaccgtca gaaaaacgac ggccgtaatg gtggaaaaca
     8581 aggtcaaagc aaccgcgaca atcgtcgctt taatgaccaa gctaagaagg agcaaggtca
     8641 gcaaaaacgt agaaatgagc gccgtcagca agaggacaaa cgttcaaatc aagtggctcc
     8701 acgtattgac tttaaagccc gtgcagcagc cctaaaagca gagcaaaatg cagagtacgc
     8761 tcgttcaagt gaggaacgct tcaagcagta tcaggctgct aaagaagcct tggctcaagc
     8821 taacaaacgc aaggaaccag aggaaatctt tgaagaagcg gctaagttag ctgaacaagc
     8881 acagcaagtt caagcagtgg ttgaagtcgt ccctgagaaa aaagaacctg cagtggatac
     8941 acgtcgtaaa aaacaagctc gaccagacaa aaatcgtgac gattatgatc atgaagaaga
     9001 tggtcctaga aaacaacaaa agaatcgaag tagtcaaaat caagtgagaa atcaaaagaa
     9061 tagtaactgg aataacaaca aaaagaacaa aaaaggcaat aacaagaaca accgtaatca
     9121 gactccaaaa cctgttacgg agcgtaaatt ccatgaattg ccaacagaat ttgaatatac
     9181 agatggtatg accgttgcgg aaatcgcaaa acgtatcaaa cgtgaaccag ctgaaatcgt
     9241 taagaaactt ttcatgatgg gtgtcatggc cacacaaaac caatccttgg atggggaaac
     9301 aattgaactc ctcatggtgg attacggtat cgaagccaaa caaaaggttg aagtggataa
     9361 tgctgacatc gaacgtttct ttgtcgaaga tggttatctc aatgaagatg aattggttga
     9421 gcgtccacca gttgttacta tcatgggaca cgttgaccac ggtaaaacaa cccttttgga
     9481 tactcttcgt aactcacgtg ttgcgacagg tgaagcaggt ggtattactc agcatatcgg
     9541 tgcctaccaa atcgtggaaa atggtaagaa gattaccttc cttgatacac caggacacgc
     9601 ggcctttaca tcaatgcgtg cgcgtggtgc ttctgttacc gatattacga tcttggtcgt
     9661 agcggcagat gacggggtta tgcctcagac tattgaagcc atcaaccact caaaagcagc
     9721 taacgttcca atcatcgtag ccattaacaa gattgataaa ccaggtgcta acccagaacg
     9781 cgttatcggt gaattggcag agcatggtgt gatgtcaacc gcttggggtg gagattctga
     9841 atttgttgaa atctcagcta aattcaacca aaatatcgaa gaattgttgg aaacagtcct
     9901 tcttgtagct gaaatccaag aactcaaggc agacccaaca gtgcgtgcaa tcggtacggt
     9961 tatcgaagcg cgcttggata aaggaaaagg tgcggtcgca acccttcttg tacaacaagg
    10021 taccttgaat gttcaagacc caatcgttgt cggaaatacc ttcggtcgtg tccgtgctat
    10081 gaccaacgac cttggtcgtc gtgttaaagt tgctggacca tcaacaccag tctctatcac
    10141 aggtttgaac gaagcaccga tggcgggtga ccactttgcc gtttacgagg atgaaaaatc
    10201 tgcgcgtgca gcaggtgaag agcgtgccaa acgtgcccta atgaaacaac gtcaagctac
    10261 ccaacgtgtt agccttgaaa acctctttga tacccttaaa gctggggaac tcaaatctgt
    10321 taatgttatc atcaaggccg atgtacaagg ttctgttgaa gccctttctg cctcacttca
    10381 aaagattgac gtggaaggtg tcaaagtgac tatcgtccac tcagcggtcg gtgctatcaa
    10441 cgaatcagat gtgacccttg ccgaagcttc aaatgccttt atcgttggtt tcaacgtacg
    10501 ccctacacca caagctcgtc aacaagcaga agctgacgat gtggaaatcc gtcttcacag
    10561 cattatctac aaggttatcg aagagatgga agaagctatg aaagggatgc ttgatccaga
    10621 atttgaagaa aaagttattg gtgaagcggt tatccgtgaa accttcaagg tgtctaaagt
    10681 gggaactatc ggtggattta tggttatcaa cggtaaggtt gcccgtgact ctaaagtccg
    10741 tgttatccgt gatggtgtcg ttatctatga tggtgaactc gcaagcttga aacactataa
    10801 agacgacgtg aaggaagtta caaacggccg tgaaggtgga ttgatgatcg acggctacaa
    10861 tgatattaag atggatgatg tgattgaggc gtatgtcatg gaagaaatca agagataaga
    10921 ttttttgctc ctttcttagg tggtgaggga cgcaagcaaa ccgatggttt cattgcttat
    10981 ttttgagcct agggtctcaa aaatcccctg tgatgggact gataaatcag ttccatcact
    11041 ttcaccacgg cgaaagaagc ggatgacttc aaattgaact tcgtttcaat ttaaactgaa
    11101 aatcaagaag tttaaaatag ctaggtctgc tggcctagct tttggttcaa agtagagaaa
    11161 ggaatatcat ggcaaatcat ttccgtacag atcgtgtggg catggaaatc aagcgtgaag
    11221 tcaatgagat tttgcaaaag aaagttcgtg atccacgtgt ccaaggtgtg accatcacag
    11281 atgttcagat gttgggtgac ttgtctgttg ccaaggttta ttacaccatt ttgagtaacc
    11341 ttgcttcgga taaccaaaaa gcccaaatcg ggcttgaaaa agcaactggt accatcaaac
    11401 gtgaacttgg tcgcaatttg aaattgtaca aaatcccaga tttgaccttc gtcaaagacg
    11461 agtccatcga gtatggaaac aagattgacg agatgctacg caatctggat aagaactaaa
    11521 gaagaggggt tgcccctctt ttttggtgga ggaaaatagg ttgaatttga aatggaaaaa
    11581 tattctttta aaatatattg aaactagaat agtacgcctc tacttctaaa acattgttag
    11641 accccaatta ttcacccc
//
LOCUS       DBERMM010000052        11554 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.054, whole genome shotgun sequence.
ACCESSION   DBERMM010000052 DBERMM010000000
VERSION     DBERMM010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11554)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11554)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11554
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.054"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            432..1142
                     /gene="deoD"
                     /locus_tag="ACL8AS_001838"
     CDS             432..1142
                     /gene="deoD"
                     /locus_tag="ACL8AS_001838"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004731 - purine-nucleoside phosphorylase
                     activity [Evidence IEA];
                     GO_process: GO:0006139 - nucleobase-containing compound
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HGS1229648.1"
                     /translation="MSIHIAAQQGEIADKILLPGDPLRAKFIAENFLGDAVCFNEVRN
                     MFGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNEEVHVRE
                     LVLAQAAATNSNIVRNDWPQYDFPQIASFDLLDKAYHIAKELGMTTHVGNVLSSDVFY
                     SNYFEKNIELGKWGVKAVEMEAAALYYLAAQYHVDALAIMTISDSLVNPDEDTTAEER
                     QNTFTDMMKVGLETLIAE"
     gene            complement(1165..1689)
                     /locus_tag="ACL8AS_001839"
     CDS             complement(1165..1689)
                     /locus_tag="ACL8AS_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topology modulation protein"
                     /protein_id="HGS1229649.1"
                     /translation="MKITIIGYSGSGKSTLAEKLSNYYSIPKLHMDTLQFQPGWQDSD
                     CEWMLTEIKNFLTKHKAWVIDGNYSWCYYQERMQEADQIIFLNFLPLTCLFRAFKRYL
                     KYRGKVRESMAADCPERFDWEFIRWILWDGRSKTQKENYQKLCQEYSHKVTILRNQRE
                     LDQFLDKKRKSYNS"
     gene            complement(1742..1978)
                     /gene="rpsT"
                     /locus_tag="ACL8AS_001840"
     CDS             complement(1742..1978)
                     /gene="rpsT"
                     /locus_tag="ACL8AS_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HGS1229650.1"
                     /translation="MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELF
                     RAASSAIDKAETKGLIHKNKASRDKARLSTKLAK"
     gene            complement(2046..2966)
                     /gene="coaA"
                     /locus_tag="ACL8AS_001841"
     CDS             complement(2046..2966)
                     /gene="coaA"
                     /locus_tag="ACL8AS_001841"
                     /EC_number="2.7.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004594 - pantothenate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I pantothenate kinase"
                     /protein_id="HGS1229651.1"
                     /translation="MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISL
                     QDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSR
                     LLQILLSRTVTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
                     NGQDVDIPVYSHEVYDIVPEKKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIY
                     VDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNL
                     QNYIEPTRNRAEVILHKSKNHEIDEIYLKK"
     gene            3156..3559
                     /locus_tag="ACL8AS_001842"
                     /pseudo
     CDS             3156..3559
                     /locus_tag="ACL8AS_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698118.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            3766..4356
                     /locus_tag="ACL8AS_001843"
     CDS             3766..4356
                     /locus_tag="ACL8AS_001843"
                     /EC_number="2.1.1.172"
                     /EC_number="2.1.1.174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0052916 - 23S rRNA
                     (guanine(1835)-N(2))-methyltransferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HGS1229652.1"
                     /translation="MSKMYYAENPDAAHDIHELRVDLLGEKMTFLTDAGVFSKKMVDF
                     GSQLLLKCLDVNQGETVLDVGCGYGPLGLSLVKVYGVQATMVDINTRALDLAQRNAEK
                     NNAKATIFQSNIYARVQGRFDHVISNPPIRAGKQVVHEIIEKSKDFLEIGGDLTIVIQ
                     KKQGAPSAKSKMEDVFGNCEILKKDKGYYILRSVKE"
     gene            4353..5630
                     /locus_tag="ACL8AS_001844"
     CDS             4353..5630
                     /locus_tag="ACL8AS_001844"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001202959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016154 - pyrimidine-nucleoside
                     phosphorylase activity [Evidence IEA];
                     GO_process: GO:0006213 - pyrimidine nucleoside metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HGS1229653.1"
                     /translation="MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMA
                     VYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASF
                     GVPVAKMSGRSLGHTGGTIDKLESIRGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
                     DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELA
                     QTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELA
                     QIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQ
                     ETGVISALPAMDFGLYAMRLGAGRAVKSDVLDYETGIVFEKKIGDSVQKGEIVAKVYT
                     NEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS"
     gene            5648..6310
                     /gene="deoC"
                     /locus_tag="ACL8AS_001845"
     CDS             5648..6310
                     /gene="deoC"
                     /locus_tag="ACL8AS_001845"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004139 - deoxyribose-phosphate aldolase
                     activity [Evidence IEA];
                     GO_process: GO:0009264 - deoxyribonucleotide catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HGS1229654.1"
                     /translation="MKLNKYIDHTLLKQDAKKKQIDSLLSEAREYGFASVCVNPTWVE
                     HAKKGLEGTDVKVCTVVGFPLGATTSTVKAFETKEAIQNGADEIDMVINVGALKSGDL
                     ALVESDIRAVVEASGDKLVKVIIEACLLTDQEKVLACQLAQKAGADFVKTSTGFSTGG
                     ATIADVRLMRETVGPDMGVKAAGGARSYADALTFVEAGATRIGTSAGVAILKGELADG
                     DY"
     gene            6297..6686
                     /locus_tag="ACL8AS_001846"
     CDS             6297..6686
                     /locus_tag="ACL8AS_001846"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004126 - cytidine deaminase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0009972 - cytidine deamination [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HGS1229655.1"
                     /translation="MATTELIELAIETSKHAYVPYSHFPIGAVLVAKDGSVYTGVNIE
                     NASYPLTNCGERTAIFKAISEGQREFSELIVYGQTEKPISPCGACRQVMVEFFEQDLK
                     VTLVAKDKSTVEMTVGELLPYSFTDLN"
     gene            6777..7829
                     /locus_tag="ACL8AS_001847"
     CDS             6777..7829
                     /locus_tag="ACL8AS_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family protein"
                     /protein_id="HGS1229656.1"
                     /translation="MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVT
                     DTGGVDDKSFNQSAWEGLQDWGKEHNLSKDNGFTYFQSTSEADYANNLQQAAGSYNLI
                     FGVGFALHNAVEEAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLAGVAAAKTT
                     KTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQY
                     AAGADIVYQVAGGTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKES
                     NFVLVSTLKQVGTTVKDISNKAEKGEFPGGQVIVYSLKDKGVDLAVTNLSEEGKKAVE
                     DAKAKILDGSVKVPEK"
     gene            7973..9508
                     /locus_tag="ACL8AS_001848"
     CDS             7973..9508
                     /locus_tag="ACL8AS_001848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229657.1"
                     /translation="MAHENVIEMRDITKVFGGFVANDKINLHLRKGEIHALLGENGAG
                     KSTLMNMLAGLLEPTSGEIAVNGQVVNLDSPSKAASLGIGMVHQHFMLVEAFTVAENI
                     ILGSELTKNGVLDIAGASKEIKALSERYGLAVDPSAKVADISVGAQQRVEILKTLYRG
                     ADILIFDEPTAVLTPSEIDELMAIMKNLVKEGKSIILITHKLDEIRAVSDRVTVIRCG
                     KSIETVEIAGATNADLAEMMVGRSVSFKTEKQASKPKEVVLSIKDLVVNENRGVPAVK
                     NLSLDVRAGEIVGIAGIDGNGQSELIQAITGLRKVESGSIELKGDSIVGLHPRQITEL
                     SVGHVPEDRHRDGLILEMMISENIALQTYYKEPHSKNGILNYSNITSYAKKLMEEFDV
                     RAASELVPAAALSGGNQQKAIIAREIDRDPDLLIVSQPTRGLDVGAIEYIHKRLIEER
                     DNGKAVLVVSFELDEILNVSDRIAVIHDGKIQGIVSPETTNKQGLGVLMAGGNLGKEK
                     SDV"
     gene            9501..10559
                     /locus_tag="ACL8AS_001849"
     CDS             9501..10559
                     /locus_tag="ACL8AS_001849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229658.1"
                     /translation="MSKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTA
                     FGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGLPGQALAGWILSGWFALSHPDM
                     PRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFP
                     KDFMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGF
                     EIRAVGLNPHASEYAGISAKRTIILSMIISGALAGLGGAVEGLGTFQNVYVQGSSLAI
                     GFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSIVTASIIFFVSV
                     HYLIERFVKPKKQVKGGK"
     gene            10562..11518
                     /locus_tag="ACL8AS_001850"
     CDS             10562..11518
                     /locus_tag="ACL8AS_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229659.1"
                     /translation="MSIITLLPLLVSSMLIYSAPLIFTSIGGVFSERGGVVNVGLEGI
                     MVMGAFSGVVFNLEFAEQFGAATPWLSLLVAGLVGSVFSIIHAAATVHFRADHVVSGT
                     VLNLMAPALAVFLVKVLYNKGQTDNLSQTFGRFDFPVLANIPVIGDIFFKSTSLLGYL
                     AIAFSFLAWFILFKTQFGLRLRSVGEHPQAADTLGINVYKMRYLGVIISGFLGGIGGA
                     IYAQSISVNFSVTTIVGPGFIALAAMIFGKWNPIGAMLSSLFFGLSQSLAVIGSQLPF
                     LQGVPAVYLQIAPYVLTILVLAAFFGKAVAPKADGINYIKSK"
BASE COUNT         3290 a         2066 c         2645 g         3553 t
ORIGIN      
        1 ggtttgaaga gattttcgaa gagtataaac agaaaggtag agcgcgtgtt ctaatttgaa
       61 cacgagtaga aaacttttct aaaaacaaaa acgaaaggat gggtaaactg tattcgctga
      121 actgaatacg ggcgactctc ctctaaatca aaattaagaa aggaattgac cccaccctaa
      181 aagtagtggg aaaaagatag ttggtctagc gagcatcgct cactgcgccc aactcctatt
      241 ttcccttcgc tttttgatgg gtttggtatc tttctcaata taaaatataa aataaagaaa
      301 ggtagagcgt gtgttttgat ttgaacacga gcggaaaact cggaaaatag ataatctgac
      361 tgaaaaatca ggatttctcg tcaggttcct aattttcagt cgttttcttc tcgctctttg
      421 tatcataaat tatgtctatc catattgctg ctcagcaggg tgaaattgct gataaaattc
      481 ttcttcctgg ggatcctctt cgtgctaagt ttattgcgga gaatttcctt ggtgatgctg
      541 tttgttttaa cgaagtgcgt aacatgtttg gttacactgg tacttacaag ggtcaccgtg
      601 tatctgtcat gggaactggg atgggaatgc catctatttc gatttatgcg cgtgagttaa
      661 tcgtagacta cggtgtgaag aaattgattc gtgtgggaac tgcaggttct ttgaatgaag
      721 aggttcatgt tcgtgaatta gttttggcgc aggcggctgc aaccaactca aacatcgttc
      781 gtaatgactg gccacagtac gattttccac aaattgctag ctttgatttg cttgataaag
      841 cctaccatat cgccaaagaa cttggtatga ctactcacgt tgggaacgtt ttgtcatctg
      901 atgtctttta ctcaaattac tttgaaaaga atatcgagct tggtaaatgg ggagtcaagg
      961 ctgtggaaat ggaagcagca gctctttact atcttgctgc ccaataccat gttgatgcgc
     1021 tagctatcat gaccatctct gatagcttgg tcaatccaga cgaagacaca actgcagaag
     1081 aacgtcaaaa taccttcact gatatgatga aggttggttt ggaaaccttg attgcagaat
     1141 aattatagcc aaaaagaaag ccctttatga attgtaggac ttccttttct tatccagaaa
     1201 ttgatctagc tctctctgat ttcgaagaat agtgacttta tgtgaatatt cttggcaaag
     1261 tttttggtaa ttttcttttt gagttttgct acgcccatcc caaagaatcc atctgataaa
     1321 ctcccagtca aagcgttcag ggcaatctgc cgccatactt tctctgactt ttccacggta
     1381 tttaagataa cgcttaaagg ctctaaagag acaggtcaat ggcaaaaaat tgagaaagat
     1441 gatttggtca gcttcttgca ttcgttcttg gtagtagcac caagaataat taccatcgat
     1501 gacccaagct ttatgcttgg tgagaaagtt ttttatctcg gttaacatcc attcgcagtc
     1561 actgtcttgc caaccaggtt gaaattggag tgtgtccatg tgcagttttg gaatggagta
     1621 gtagttagat aacttttctg ctagagttga cttaccagaa ccagaatatc cgataattgt
     1681 gattttcatt ttctaccttt tcctatttgg agacaaaaaa acagcctcta tggactgttt
     1741 cttatttagc aagtttagtt gaaagacgag ctttatcgcg gcttgctttg tttttgtgaa
     1801 tcaaaccttt agtttctgct ttatcgatag ctgagctagc agcacggaaa agttcttcag
     1861 atgggtttgc ttcgaaagct tttatagcag tacgcatagc tgatttttga gctgagttct
     1921 tttcgttttg tttaacgttc aattcagcgc gtttgatagc tgatttaatg tttgccaatg
     1981 ttcttacctc catatttact aactatacca ttatatatga aaacttacgt tttgacaagg
     2041 gaaaattact tttttaagta aatttcatcg atttcatggt tcttgctttt atgaagaatc
     2101 acttctgcac gatttctggt tggttcaata taattttgca gatttgtgag attgatactg
     2161 atccagacct gatgggcaaa ggactccact tccccaatcg gcatctgagt aaaacgataa
     2221 tagtagctat cagggtcgtt ttgggctagg ctcagcatct tcaagaaacg gtccagatac
     2281 caactttcaa tatcatccac tccagcatct acatagatgg aaaagtcaaa gaagtcagtg
     2341 atatagagac gatcgttttg tggattttga aagacattaa ttccctcaac aattacaaaa
     2401 tcagcagctt tgacactttg tttcttttcg ggtacgatgt cgtaaacttc atgagaatag
     2461 acaggaatat ctacatcttg tccatttttg atgcggtcca agaagttgag aagagcttcc
     2521 atatcatagc tttcaggaaa tcctttacga tttaaaatcc cctgctcaat caaggtttga
     2581 ttgggataga gaaaaccatc agttgtaacc aactcaaccg tagcatctgt aaccgtacgg
     2641 gacagtagga tttgaagtag gcgactggtt gtggattttc caacggcaac actcccagaa
     2701 accccaataa taaaaggttg agatttactt tcacgttgga ggaaaattcc ttttgaaaag
     2761 gctaaatctt ccttagttcg cttgtaaatc tgaatcagat gagccaaggg gagatagata
     2821 tctgtaacgt cttggagact gatttggtca ttaaaactct tgatagattc caattcttct
     2881 tctgtcaaag gaggtgttgt ctttcgatgt aaagattgcc aagtctggcg gctgattttt
     2941 tcaaaatgta aaaattcgtt ggtcatttgt tttcccctag atattttgtc tatcatacca
     3001 taaaaagcta aaaaaataaa gcggtttctt gaatgtggta agtcaatggt atatagtata
     3061 agtgatcaat ttattgatga aataggagat agattctact gatttataag cttataaagg
     3121 gggcttttta gttcacaact tataggaggt gtactatgaa aatcttaaaa cgttacatat
     3181 tggaactctg ttttatttta agttttgctt taccttttat aaaaggaacc aatgcagata
     3241 atggtagatg ctttgtggaa acctattacg gttttacttt tttgatggaa catgctattg
     3301 taacagctgt ctttatctgt tcgttcttaa ttgctttctt actaaaaaac gatggacgaa
     3361 atggattgct gcgggtagtt attgcttttt agtcctacgg attgcgacag agggttattt
     3421 cttccacatg tcactagaag atttgatacg actttggaca agtttggaaa tcctgacaca
     3481 aacgtatcag ttgggctttt atctaaacat tttgttagga attttgttga taataaagta
     3541 ttttaaggtt aagcaataga aataataatc tgcctgatta tagatgataa actttttgtt
     3601 tttatctgga ctgtgatatt tatagttcta aatggtttat tatttataag tgttgaaaga
     3661 gattgaagaa aatggcttcg tgacttgctt tcttcggtct ttttcgtttt attatcaatt
     3721 tgtaaacgat ttacaatttg agtcaaatta tggtaaaata gtgtcatgag taaaatgtac
     3781 tatgcagaaa atcctgacgc tgctcacgac attcatgagt tgagagtgga cttgttggga
     3841 gaaaaaatga cttttttgac agatgcgggt gtttttagca agaaaatggt tgactttgga
     3901 agtcaactct tgctcaagtg tctggatgtc aaccaaggag agacagtcct agatgtaggc
     3961 tgtggttatg gtccattagg tttgtccttg gtcaaggttt acggagttca ggcgaccatg
     4021 gttgatatta acactcgtgc cctggattta gctcagagaa atgctgaaaa aaataatgca
     4081 aaagcgacga tatttcaatc taatatttat gcaagagttc aagggcgatt tgaccatgtc
     4141 atttccaatc ctcctatccg tgcgggcaag caagtcgttc atgaaatcat cgagaaaagt
     4201 aaagatttct tggaaattgg tggagatttg accatcgtca tccagaaaaa acaaggagct
     4261 ccaagtgcca aatctaagat ggaagatgtg tttggcaatt gtgaaatcct taaaaaagac
     4321 aagggatact atatccttag aagtgtgaaa gaatgagagc agttgattta atccaaaaaa
     4381 aacgagacgg tcaagaactg acttcaagtg aaattgaatg gctgatagaa ggctatgtat
     4441 caggaactgt tcctgattat cagatgtctg cctttgctat ggctgtttat tttaaaggaa
     4501 tgacgactcg agaaatctct gatttaacga tgaatatggt taagactggg caagagtttg
     4561 acctgtcagc cattgatggt gtgaaagttg acaagcattc tactggtggt gtcggcgata
     4621 aggtaacctt gattttagct cctcttgttg ctagcttcgg tgtgcctgta gcaaaaatga
     4681 gtggtcgtag tcttggccat acaggcggaa caattgataa attggagtcc attaggggct
     4741 atcaagtaga acgtagtcaa gaggatttta ttcgtcaggt tcaggatatt ggagtatctg
     4801 tcattgggca atcagaccag ctggtcaaag cagataagct tctctatgcc cttcgtgatg
     4861 tgaccgcaac tgtcgacacg attcctttga ttgcgagttc ggtgatgagc aagaaaattg
     4921 cggcaggggc ggatgctatt ttgctagacg tgactgtcgg tgagggtgcc ttcatgaaga
     4981 cggttgatga ggcgcgtgag ttggctcaaa ctatggtaga tcttggtaag gttgttggac
     5041 ggaagacagt agcagtgatt acggatatga gccagccttt gggacgagcg attggaaatc
     5101 gtctggaaat ccttgaagca ttggagattt tgcaaggtca aggacgtcag gatattaccc
     5161 actttatttg tgaattggct caaattatgc ttggtttggc aaatgttaac aaaactgttg
     5221 aagaagttcg ccaacatctt gaaaatggtc aagcactggc taagtttgag gaaatggtgc
     5281 aagcccaagg tggagacttg gaagacctct atcgtcctgt aaatgtagct catgtggtgg
     5341 aaatccctgc tcaggaaacg ggtgtcattt cagctcttcc agctatggac tttggtcttt
     5401 atgccatgag gctgggtgct ggtcgtgcag ttaagtctga tgtcttggac tatgaaacag
     5461 gaattgtttt tgaaaagaag attggagact ccgttcaaaa gggtgaaatt gttgcaaaag
     5521 tatacacaaa tgaaaaaatt ccacctcaac tagttacaga tttccaaaaa tgtgttaaaa
     5581 taagtgatga agtgaaaaaa atccgtgaaa ttgtagaaat catctcctaa atggagggaa
     5641 aaccgaaatg aaattaaata aatatataga tcatacgctt ttaaaacaag atgcaaagaa
     5701 aaaacaaatt gatagtttgt tgtctgaggc tagagagtat ggctttgcca gtgtttgcgt
     5761 taatccgacc tgggttgaac atgctaaaaa aggacttgaa ggcacagatg ttaaggtttg
     5821 cacagtagta ggtttcccct tgggagcaac aacttcaact gtgaaagctt ttgaaacaaa
     5881 agaagctatc caaaatgggg ctgatgagat tgacatggta atcaatgttg gggctctcaa
     5941 gtcaggtgat ttggccttgg ttgagtcgga tattcgtgca gtagtggaag caagtgggga
     6001 caagttagtg aaagttatta ttgaagcttg ccttctgaca gaccaagaaa aagttttggc
     6061 ttgccaatta gcccaaaaag caggagctga ctttgtcaaa acatctactg gcttttcaac
     6121 tggtggtgct acgatagcag atgttagatt aatgcgtgaa acagttggac ctgatatggg
     6181 tgtcaaggcc gccggtggag ctcgttctta tgcagatgct cttacctttg tcgaagcagg
     6241 tgcgacccgt atcggaacgt cagctggggt agctatttta aaaggagaat tggcagatgg
     6301 cgactactga gttgattgaa ctggcaattg aaaccagcaa acatgcctat gtcccctatt
     6361 ctcactttcc tatcggagca gttttagtag ccaaagacgg aagtgtttac acgggagtga
     6421 atatcgaaaa tgctagctat cctttgacca attgcggtga gagaacagct atttttaagg
     6481 ctatatctga aggccaaaga gaattttcag aattgattgt ctatggtcaa actgaaaaac
     6541 cgatttcacc atgtggtgct tgtcgccaag taatggtcga attttttgaa caagatttaa
     6601 aagtgaccct agtcgcaaaa gataaatcga cggtcgagat gacggtcggg gagttacttc
     6661 catactcttt tacagactta aattagtctg agtcgctctt tgagtggcaa gggtctttgt
     6721 gaccaatcaa tccatacttg caacatcgtt gcacatctta tttaggaggt tcagtaatga
     6781 acaagaaaca atggctaggt cttggcctag ttgcagtggc agcagttgga cttgctgcat
     6841 gtggtaaccg ctcttctcgt aacgcagctt catcttctga tgtgaagaca aaagcagcaa
     6901 tcgtcactga tactggtggt gttgatgaca aatcattcaa ccaatcagct tgggaaggtt
     6961 tgcaagactg gggtaaagaa cacaatcttt caaaagataa cggtttcact tacttccaat
     7021 caacaagtga agctgactac gctaacaact tgcaacaagc ggctggaagt tacaacctaa
     7081 tctttggtgt tggttttgcc cttcacaatg cagttgaaga agcagctaaa gaacacactg
     7141 acttgaacta tgtcttgatt gatgatgtga ttaaagacca aaaaaatgtt gcgagcgtaa
     7201 ctttcgctga taatgagtca ggttaccttg caggtgtggc tgcagcaaaa acaactaaga
     7261 caaaacaagt tggttttgta ggtggtatcg aatctgaagt tatctctcgt tttgaggcag
     7321 gattcaaggc tggtgttgcg tcagtagacc catctatcaa agtacaagtt gactacgctg
     7381 gttcatttgg tgatgcggct aaaggtaaaa caattgcagc cgcacaatac gcagccggtg
     7441 cagatattgt ttaccaagta gctggtggta caggtgcagg tgtctttgca gaggcaaaat
     7501 ctctcaacga aagccgtcct gaaaatgaaa aagtttgggt tatcggtgtt gaccgtgacc
     7561 aagaagcaga aggtaaatac acttctaaag atggcaaaga atcaaacttt gttcttgtat
     7621 ctactttgaa acaagttggt acaactgtaa aagatatttc taacaaggca gaaaaaggag
     7681 aattccctgg cggtcaagtg atcgtttact cattgaagga taaaggggtt gacttggcag
     7741 taacaaacct ttcagaagaa ggtaaaaaag ctgtcgaaga tgcaaaagct aaaatccttg
     7801 atggaagcgt aaaagttcct gaaaaataat ggatggaagt catttcttag gaagcggcca
     7861 agggccgctt ttttaagagt tgagacaaag tcattttgtc tcagtaaagc ttgctactag
     7921 acaaactagc aagttttatt gaaataaaat aagactctga aaggaagagc acatggcaca
     7981 cgaaaatgtc attgagatgc gtgatattac caaggtgttt ggtggatttg ttgccaacga
     8041 caaaatcaac ttgcacctac gaaaaggtga aattcatgca cttttaggag aaaatggggc
     8101 tggtaagtcc acgctaatga acatgttagc aggccttctt gaaccaacca gtggtgaaat
     8161 cgcggtcaac ggtcaagttg tcaatctcga ctccccatct aaagcagcta gcttgggaat
     8221 cgggatggtt caccagcact ttatgttggt tgaagccttc acagtggctg aaaacatcat
     8281 tttaggtagt gaattgacta aaaatggtgt gctagatatc gctggagcta gcaaagaaat
     8341 caaggctctt tctgaacgtt atggcttagc tgttgaccct tctgccaagg tagcagatat
     8401 ctcagttgga gcccaacaac gtgtagaaat tttaaaaaca ctttatcggg gggctgatat
     8461 ccttatcttt gacgaaccaa cggctgtttt gactccatca gaaattgatg agttgatggc
     8521 tattatgaaa aatcttgtca aagaaggaaa atcaattatc ttgattaccc acaaattgga
     8581 tgaaattcgc gcagtttctg accgtgttac agttatccgt tgtgggaaat caattgaaac
     8641 cgttgaaatt gcaggggcta ccaatgctga tttggcggaa atgatggtag gacgttctgt
     8701 ttcctttaaa acagagaagc aagcctctaa accaaaagaa gtggttttgt ctatcaaaga
     8761 tttggtggtc aatgaaaacc gtggtgttcc agctgttaaa aatctgtcct tggatgttcg
     8821 tgctggagag attgttggta ttgcggggat tgatggaaat ggtcagtctg aactgattca
     8881 agccattaca ggtcttcgta aggttgaatc tggtagcatt gagctaaaag gagattcaat
     8941 tgtaggcttg cacccacgtc agattacaga actaagtgtt gggcacgttc cagaagaccg
     9001 tcaccgtgat ggcttgattt tggaaatgat gatatctgaa aatattgccc ttcaaaccta
     9061 ctataaagaa ccacatagta aaaatggaat tttgaattat tcaaatatta cttcttatgc
     9121 taaaaagctg atggaagagt ttgatgttcg cgctgccagt gaattagttc ctgcagctgc
     9181 actctcagga ggaaatcaac aaaaagcaat tattgctcgt gaaattgatc gagatcctga
     9241 tctccttatc gttagccagc caactcgtgg gttggatgtc ggtgccattg agtatatcca
     9301 caaacgcttg attgaagagc gtgataatgg caaggctgtc cttgttgtca gctttgaatt
     9361 ggatgagatt ttaaacgtct cagaccgtat tgccgttatc cacgatggta agattcaagg
     9421 tattgtatca ccagaaacaa ccaataaaca aggacttggt gtcttgatgg ctggtggaaa
     9481 cttgggaaag gagaagagtg atgtctaaaa aattacaaca aatttcggtt cccttgattt
     9541 ctgtattcct aggaatttta ctcggagcca ttgtcatgtg gatcttcggt tatgatgcta
     9601 tttggggcta cgaagaattg ttctatacag cctttggcag tctgcgtggg attggagaaa
     9661 tcttccgtgc tatgggtcct ctggtcttga ttggtcttgg ttttgcggtt gccagtcgag
     9721 ctggtttctt taacgtcgga cttcctggtc aggctttggc aggttggatt ctcagtggtt
     9781 ggtttgccct gtcgcatcca gatatgcccc gtcccttgat gattctagca accatcgtga
     9841 ttgccttgat tgctggtggg attgtcggag cgattccagg tattcttagg gcctatctag
     9901 ggacgtcaga ggttattgta accatcatga tgaactacat tgtcttgtat gtagggaatg
     9961 cctttatcca tgctttccct aaagacttca tgcaaagtac agattcgacc attcgtgttg
    10021 gggctaatgc aacctatcag acaccttggt tagctgagtt gactggtaac tcacggatga
    10081 atattggtat tttctttgcc atcattgccg ttgcagttat ttggttcatg ctcaagaaaa
    10141 caactcttgg ttttgaaatc cgtgcagttg gtcttaatcc acatgcttca gaatatgctg
    10201 gtatttctgc caagcggact attattctat ctatgattat ttcaggtgcc ttggcaggtc
    10261 ttggtggagc tgttgaaggt ttgggaacct tccagaacgt ctatgttcaa ggttcgtcat
    10321 tagctatcgg atttaacgga atggcggtta gtttgcttgc ggccaactca ccaattggta
    10381 tactctttgc agccttccta tttggcgttc tccaagttgg ggctcctggt atgaatgcgg
    10441 cgcaggtacc atctgagctt gtcagcattg taacagcgtc tattatcttc tttgtcagtg
    10501 ttcattacct tatcgaacgc tttgtcaaac cgaaaaaaca agttaaagga ggtaagtaaa
    10561 gatgtctatt ataaccttgc tccccctctt ggtgtcttct atgctgattt actcagcacc
    10621 tctcatcttt acaagtatcg gtggtgtttt ctctgaacgt ggtggtgtgg taaacgttgg
    10681 ccttgaagga attatggtta tgggtgcctt ttctggagtt gtctttaacc ttgaatttgc
    10741 agaacaattt ggagcagcaa ctccatggct atccttgctt gtagcaggat tggttggtag
    10801 tgttttctct atcatccacg cagcagcgac ggttcatttc cgtgcagacc atgttgtcag
    10861 cggtacggta ttgaacttga tggcgcctgc cttggctgtt ttcttagtta aagttcttta
    10921 taacaaagga caaaccgaca acctaagtca aacttttgga cgctttgatt tcccagtctt
    10981 ggcaaatatc ccagtgattg gtgatatctt cttcaagtca actagtctac ttggttatct
    11041 ggcgattgcc ttctcattcc ttgcttggtt tattctcttt aagactcaat ttggtcttcg
    11101 tctccgctct gtcggtgaac atcctcaagc agcggatacc ttgggaatca acgtctacaa
    11161 gatgagatat ttaggggtta ttatttcagg ttttctaggt ggaattggcg gagcgattta
    11221 tgcgcaatca atctcagtta acttctcagt gacaactatt gttggacctg gatttatcgc
    11281 ccttgctgcg atgatctttg ggaaatggaa tccaatcggt gctatgcttt ctagtctctt
    11341 ctttggactt tcacaaagtt tggctgttat cggttctcaa ttgccgttcc tacaaggagt
    11401 gccagcggtt tatcttcaaa ttgcacctta tgttttgaca attcttgtct tagcagcctt
    11461 ctttggaaaa gcagtcgcac caaaagcaga tggtatcaac tacatcaaat caaaataagc
    11521 atacaaaaaa acgtcagtcc aatgactgaa ctgc
//
LOCUS       DBERMM010000053        10755 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.055, whole genome shotgun sequence.
ACCESSION   DBERMM010000053 DBERMM010000000
VERSION     DBERMM010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10755)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10755)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10755
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.055"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(117..1541)
                     /locus_tag="ACL8AS_001851"
     CDS             complement(117..1541)
                     /locus_tag="ACL8AS_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HGS1229660.1"
                     /translation="MTRYQNLVNGKWKSSEQEITIYSPINQEELGTVPAMTQTEADEA
                     MQAARAALPAWRALSAIERAAYLHKTAAILERDKEKIGTILAKEVAKGIKAAIGEVVR
                     TADLIRYAAEEGLRITGQAMEGGGFEAASKNKLAVVRREPVGIVLAIAPFNYPVNLSA
                     SKIAPALIAGNVVMFKPPTQGSISGLLLAKAFEEAGIPAGVFNTITGRGSEIGDYIIE
                     HKEVNFINFTGSTPIGERIGRLAGMRPIMLELGGKDAALVLEDADLEHAAKQIVAGAF
                     SYSGQRCTAIKRVIVLESVADKLATLLQEEVSKLTVGDPFDNADITPVIDNASADFIW
                     GLIEDAQEKEAQALTPIKREGNLLWPVLFDQVTKDMKVAWEEPFGPVLPIIRVASVEE
                     AIAFANESEFGLQSSVFTNDFKKAFEIAEKLEVGTVHINNKTQRGPDNFPFLGVKGSG
                     AGVQGIKYSIEAMTNVKSIVFDVK"
     gene            complement(2086..4365)
                     /gene="pulA"
                     /locus_tag="ACL8AS_001852"
     CDS             complement(2086..4365)
                     /gene="pulA"
                     /locus_tag="ACL8AS_001852"
                     /EC_number="3.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051060 - pullulanase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I pullulanase"
                     /protein_id="HGS1229661.1"
                     /translation="MYNYPMRIHYHRKNGEYDTCSFVKSQDQRIDLLTYKEDYFGALF
                     SFEHPSSHVIESLNFVVHTGQTSKEYSIRFNHYPLLTEVWILEGDDRIYYSENPAIAS
                     PFYKNQNPFAFDKAINSASFDHHWGYQGELGCRVEDNQAHFSLWSPTATEVQVVVYES
                     AANDAPVWKTFEMKRGNSYSYNHKDNTIGVWSLDVEEDLVGKTYQYQVQFPHHQTLTR
                     DPYTIATSPDGKRSAILSHVEKQVENFEVKHGSEATWRLENPCKAVICEMHIRDLTKS
                     PTSGVDEHLRGTFLGAAQAGTVNQYGQSTAFDYIKKLGYNYVQLQPIADRHKEYDEDG
                     NVTYNWGYDPQNYNAPETSFSTNPDDPAQVIRDLKVMVQAYHDAGIGVIMDVVYNHTF
                     SVVDAPFQTTVPDYYYRMNPDGTFQNGTGVGNETASEHEMFRKYMIDSLLYWVQEYNI
                     DGFRFDLMGIHDVKTMQMIRQSLDEIDSNIILYGEGWDMGTGLTPYDKAKKDNAYQMP
                     NIGFFNDNQRDAVKGGEVYGAIKSGFVSGAATEPILAKAILGSRELGTYTHPNQVLNY
                     VEAHDNYNLHDLLATLHPDQSSEQIMRKVETATAMNLLMQGMAFMEIGQEFGRTKLVA
                     TGENGELTHDDRERAMNSYNAPDSVNQVNWNLINERQDSIEFIRQVIRLKTKTGAFSY
                     SSYDEIYHHVFVHSAIEHSGCLIYEVHGKEHLLVVVNAKSEPYQFENAGNLAMLVTNS
                     RSKEDNVLNDISLAVLSVL"
     gene            complement(4477..6435)
                     /gene="ligA"
                     /locus_tag="ACL8AS_001853"
     CDS             complement(4477..6435)
                     /gene="ligA"
                     /locus_tag="ACL8AS_001853"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HGS1229662.1"
                     /translation="MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELET
                     AYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHP
                     TYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDIT
                     VRGECYMPRASFDQVNQVRQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQE
                     ASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVV
                     IKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPV
                     QLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIP
                     TNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFA
                     ANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGS
                     KASQLLLQYFHSIENLYQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETG
                     VNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVV
                     VGADAGSKLQKAQELGIQVRDEAWLESL"
     gene            complement(6528..7706)
                     /locus_tag="ACL8AS_001854"
     CDS             complement(6528..7706)
                     /locus_tag="ACL8AS_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001083019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HGS1229663.1"
                     /translation="MNRYAVQLISRGAINKMGNMLYDYGNSVWLASMGTIGQTVLGMY
                     QISELVTSILVNPFGGVISDRFSRRKILMTADLVCGILCLAISFIRNDSWMIGALIVA
                     NIVQAIAFAFSRTANKAIITEVVEKDEIVIYNSRLELVLQVVGVSSPVLSFLVLQFAS
                     LHMTLLLDSLTFFIAFVLVAFLPKEEAKVQEKKAFTGRDIFVDIKDGLHYIWHQQEIF
                     FLLLVASSVNFFFAAFEFLLPFSNQLYGSEGAYASILTMGAIGSIIGALLASKIKANI
                     YNLLILLALTGVGVFMMGLPLPTFLSFSGNLVCELFMTIFNIHFFTQVQTKVESEFLG
                     RVLSTIFTLAILFMPIAKGFMTVLPSVHLSSFLIIGSGVIILSCISFIYVRTHFEKLI
                     "
     gene            complement(7786..8649)
                     /locus_tag="ACL8AS_001855"
     CDS             complement(7786..8649)
                     /locus_tag="ACL8AS_001855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012291596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HGS1229664.1"
                     /translation="MEHLGKVFREFRTSGNYSLKEAAGESCSTSQLSRFELGESDLAV
                     SRFFEILDNIHVTIENFMDKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQREQLEK
                     SKSSTTPLYFELNWILLQGLICQRDASYDMKQDDLDKVADYLFKTEEWTMYELILFGN
                     LYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLEHSSFYNANYFE
                     AYTEKIIDKGIKLYERNVFHYLKGFALYQKGQCKEGCKQMQEAIHIFDVLGLPEQVAY
                     YQEHYEKFVKS"
     gene            complement(8652..10553)
                     /locus_tag="ACL8AS_001856"
     CDS             complement(8652..10553)
                     /locus_tag="ACL8AS_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000584877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HGS1229665.1"
                     /translation="MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKST
                     LLKILVGEEEPTSGEINKKKDISLSYLAQDSRFESENTIYDEMLHVFNNLRRTERQLR
                     QMELEMGEKSGEDLDKLMSDYDRLSENFRQAGGFTYEADIRAILNGFKFDESMWQMKI
                     AELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDIETIAWLENYLVNYSGALIIVSHD
                     RYFLDKVATITLDLTKHSLDRYVGNYSRFVELKEQKLVTEAKNYEKQQKEIAALEDFV
                     NRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTFQSEKTSGNVVLTVENTAI
                     GYDGEVLSQPINLDLRKMNAVAIVGPNGIGKSTFIKSIVDQIPFIKGEKRFGANVEVG
                     YYDQTQSKLTPSNTVLDELWNDFKLTPEVEIRNRLGAFLFSGDDVKKSVGMLSGGEKA
                     RLLLAKLSMENNNFLILDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINRVAT
                     HVLELSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEASPVNDYQAQKESQK
                     EVRKLMRQIESLEAEIEELESQSQAISEQMLETNDADKLMELQAELDKISHRQEEAML
                     EWEELSDQV"
BASE COUNT         3227 a         2362 c         1921 g         3245 t
ORIGIN      
        1 tgtactattc tagtttcaat atactataat accaaaaagt tcgtattttt tctataatta
       61 ttattatttt atagcaaaaa aataaaacca ggaaaacaat ttcctgattt tacacgttat
      121 ttcacatcaa aaacaatgga tttgacattt gtcatcgctt caatgctata tttaattcct
      181 tgcactccag ctccagaacc tttgacacca aggaatggga aattatctgg accacgctgg
      241 gttttattat taatgtggac tgtacctact tcaagttttt cagcaatttc aaaggctttt
      301 ttgaaatcat ttgtaaagac tgatgattga aggccgaatt cagattcgtt ggcaaaggca
      361 atagcttcct ctacactagc cacacgaatg attggtaaaa caggaccaaa tggctcttcc
      421 catgccactt tcatatcttt tgtaacttgg tcaaaaagca ctggccagag gagattgccc
      481 tcacgtttga ttggtgtaag agcctgagcc tctttttctt gtgcatcctc aatcaagccc
      541 caaatgaagt cggctgaagc attgtcaata acaggtgtaa tatcagcatt gtcaaatgga
      601 tcaccaactg ttaatttaga aacttcttcc tgaagcaaag tagctaattt atctgctaca
      661 ctttcgagaa caatgacacg tttaatggcc gtgcaacgtt gtcctgagta gctaaaggct
      721 cccgcaacaa tttgcttggc agcatgttcc aaatctgcat cttctagtac aagagctgca
      781 tctttcccac caagttccaa catgatagga cgcataccag ctaaacgacc aatacgttct
      841 ccaatagggg ttgaacctgt aaagttgatg aagttgactt ctttgtgctc aatgatataa
      901 tccccaattt ctgaaccacg acctgtaatg gtgttgaaaa cacctgccgg aatccctgct
      961 tcttcaaatg ctttagccaa caagagtcca gaaatggaac cttgtgttgg tggcttaaac
     1021 atgaccacat tccctgcaat caaggcaggt gcaattttag aagcagataa attaactgga
     1081 taattaaagg gagcaatcgc tagcacgata ccaactggtt cacgacggac aacagccagt
     1141 ttgtttttac ttgctgcctc aaaaccacca ccttccattg cttgtccagt gatacggaga
     1201 ccttcctcag cagcataacg aatcaagtct gctgtacgca ctacttctcc aattgctgct
     1261 ttaatccctt ttgctacttc tttggcaagg atagtaccaa ttttttcctt atcgcgttct
     1321 aaaatagctg ctgttttatg caaataagcc gcacgttcaa ttgctgataa agctcgccat
     1381 gctggcaggg ctgcacgcgc agcttgcata gcctcatcag cttcagtctg agtcatggct
     1441 ggaactgtac ccaattcttc ttgattgatt ggtgaataaa tcgtaatttc ttgttcagat
     1501 gatttccatt ttccatttac taaattctga tatcttgtca aattcttgtc ctcctgaaaa
     1561 tgattaagat atattttacc aaattttcag aaaatcacaa ccctttttgc aaaatttttg
     1621 agattatttt cacaagcttg atttttcaaa gtatactcaa taaaaataaa aaaaatccac
     1681 tacatcaagg cgagactaat gtggtttgaa gaaattttcg aagagcgtga atgagtatca
     1741 tctatagtaa aataaaaaaa ctgaacaatt tggttgggga cagtcaaacc aatttctcac
     1801 aatgttttag aaacaagggt gtgctattcc aatttcaggc tactataact gtcatagatt
     1861 gctgaaacaa agtctaggta aaagtcttca taataaaaag accccctatc aagtgttcaa
     1921 aaactttgat aggaggtctt gttttgtgaa aatatttatc aaattttcta tacaagtgag
     1981 ctgttagcca ggttctttct attctttcaa tttcaatgaa tggatttttt accaatactc
     2041 ataactggga atttgtctgt gtaaaaatag cgagatagat ggtatttata aaacactcaa
     2101 gacagctaga ctaatatcat ttaaaacatt atcttctttt gagcgactgt tggttaccaa
     2161 catagctaaa tttcctgcat tttcaaattg atagggttct gatttagcat tcacaactac
     2221 caagaggtgt tctttgccgt gaacttcata gataaggcag ccgctatgtt caatcgcaga
     2281 atgcacaaag acatgatggt aaatttcatc atagctagag taagaaaagg caccagtttt
     2341 tgtcttcaat cggatgactt gacggataaa ctcaatactg tcttgacgct cattaatcaa
     2401 gttccagttc acttggttca cactgtcagg agcattatag ctattcatcg cacgctctct
     2461 atcatcatgg gtcaactcac cattttcacc agtcgcaacc agtttggtac gaccaaattc
     2521 ttgaccgatt tccataaagg ccatcccctg catgagcaga ttcatggctg tggcagtttc
     2581 gaccttgcgc atgatttgct ctgaactttg gtctggatga agggttgcca ataaatcgtg
     2641 aagattgtaa ttgtcatggg cttctacata gttaagcacc tgatttggat gtgtataggt
     2701 tcctaattca cgacttccta ggattgcttt agctagaatt ggctctgtcg cagcaccact
     2761 gacaaaacct gacttgatag caccataaac ttctccccct ttgacagcat cgcgctgatt
     2821 gtcattaaag aaaccaatat ttggcatctg gtaggcattg tccttcttgg ccttatcata
     2881 aggggtaaga cctgttccca tatcccatcc ttctccatag aggataatgt tggagtcgat
     2941 ttcatccaag ctttgacgaa tcatctgcat ggtcttgaca tcatgaatcc ccatcaagtc
     3001 aaaacggaag ccgtcaatat tatattcctg cacccagtat agaagagaat caatcatata
     3061 cttgcgaaac atttcgtgtt cactggctgt ttcatttcca acacccgttc cattctggaa
     3121 ggtaccatct ggattcatac gataatagta atcagggact gttgtttgga atggtgcatc
     3181 aacaactgag aaggtatggt tatagactac atccataatg actccaatac ccgcatcgtg
     3241 ataagcttga accatcacct tcaaatcacg aatgacctga gctggatcat ctggattagt
     3301 tgaaaaacta gtttctggcg cgttatagtt ttgtggatca taaccccagt tgtaggttac
     3361 atttccatcc tcatcgtatt ctttatgacg gtctgcaatt ggttgcaatt gaacataatt
     3421 gtagcccagc ttcttgatgt aatcaaaagc agttgactgg ccgtattggt taactgttcc
     3481 agcctgagca gcacccaaga aagttcctcg aagatgttca tctacacccg atgtaggtga
     3541 tttagtcaaa tcacgaatgt gcatttcaca gataactgcc ttacatggat tttccaagcg
     3601 ccaagtagcc tccgaaccgt gcttaacctc gaagttttca acttgctttt ctacatggct
     3661 cagaatagct gaacgtttgc catcagggct ggtcgcgatt gtataaggat cacgtgtcag
     3721 tgtttggtga tgagggaatt ggacttgata ctgataagtc ttacctacca aatcttcttc
     3781 aacatccaaa ctccagacac cgattgtatt gtccttatga ttataagagt agctattgcc
     3841 tcttttcatc tcaaaagtct tccaaacggg tgcatcatta gcagctgatt cataaacgac
     3901 aacttgcact tctgtcgctg taggtgacca gagggaaaaa tgagcctgat tgtcctctac
     3961 acggcaaccc aattctcctt ggtaacccca atgatgatca aaactagcac tgttaatggc
     4021 cttatcaaag gcaaaaggat tttgattttt atagaaagga ctggcaatag caggattttc
     4081 agagtaataa atcctatcat cgccttccaa aatccagacc tctgtcaata ggggatagtg
     4141 attaaaacgg atagaatatt ctttactagt ttgacctgta tgaaccacaa aattcaagct
     4201 ttctataaca tgtgaacttg ggtgttcaaa gctaaataaa gctccaaaat aatcttcttt
     4261 gtaggttagc aaatcaattc gttgatcctg actttttaca aaggagcaag tgtcatattc
     4321 tccattctta cgatggtaat gaatgcgcat agggtagtta tacatttttt atttttcctt
     4381 tttactttgt ttctatttca ctaataaatt tttgtcaatc tcgtctcaat taacagacat
     4441 agtcatattc tctaaactct gtttttaaac gatccattac aaactttcta gccatgcctc
     4501 atctctgacc tggataccaa gttcttgtgc tttttgcagt ttacttccag cgtctgcacc
     4561 taccacgacg aggtcggtct ttttagaaac actacctgtc actttggcac ccagactttc
     4621 gagtttactt ttagcttctg agcgcttgag tcgttccaat tttcctgtca ataccacggt
     4681 caaacctgac aaggccgcat ccgctactac cgtctgtcct ttatagtcca gattgacccc
     4741 agtttctttc aattctctga gcagaatttc agagccttct gtcgcaaaat aagtctgaag
     4801 acttttggca atcacgccac ctagactttc aatactagcc acttcctctg aatctgcctg
     4861 atacagattt tcaattgaat ggaaatattg aagtaaaagc tgactagcct tgcttccgac
     4921 atgacgaatt cccaaaccaa ataagagctt ctcggcagaa ttttcctttg atgcttggat
     4981 agcctgatac agtttagcag cggacttttc cttaaccccc tctaaaagga ggaaatcctc
     5041 ttcttgcaaa cgataaatat ccgccacatc cttgactaaa ttagcagcaa aaagcttctc
     5101 aacaatagat ggaccaaggc ctgtaatatt catagcatca cgagaagcaa agtgaatcaa
     5161 gccttccatg atttgagcag ggcaacgcgg attgatacaa cgtagggcca cttcatcttc
     5221 aaagtgcaac aagtcagagt tacaacttgg acagtttgta gggatatcta gtttttcttc
     5281 agaaacccgt ttggactcta ccacacgtaa aacggcaggg atgatgtcac cagccttata
     5341 tacaatgacc gtatcgtctt ttcggatatc tttttcagca atataatcta cattgtgcag
     5401 ggtcgcacgg ctaacagtcg taccggcaag ttgtactggt gttagattag cagttggagt
     5461 tacaacaccg gtacggccaa ctgtccagtc aactgataag agttgagctt ctttttcttc
     5521 agcagggaac ttgtaggcta ctgcccactt tggagcctta acggtaaaac caagttcttc
     5581 ttgacttgct aggtcgttga ccttgattac cactccatca atatcgtaag gcagattttc
     5641 ccgttcctgt cctacttctt ggataaaatt ccagatttca tctatgtttt cagccaagat
     5701 tcgcttagga ttgaccacaa aacctagttg ttctaggtac ttcaaaccct tttcttggct
     5761 atcacgagtt gaagggctgg cttcttgata gagaaacgtt gcaagattac gcttggcaac
     5821 tactgctgta tccaactgac gcagagttcc tgctgccgca ttacgaggat tagcaaattc
     5881 aggctctcca ttttcttggc gcacttggtt aacttggtca aaggaagcgc gtggcatgta
     5941 acattcccca cgaactgtga tatctagttc ttctggcaaa gtcaaaggga tgtccttaac
     6001 acgcttgagg ttttctgtga tattttcacc aattgaacca tctccacgtg ttaccccagc
     6061 aaccaaaatc cccttttcat aagtcagcga gatagataag ccatcgattt tcagctcaca
     6121 aatataggtc ggatgagcca cttccttacg aacacgcgca tcaaaagcat ctagctcctc
     6181 acgtgaaaaa gcatcctgca aactataaag aggatactga tgactgtatt tttcaaaacc
     6241 atctaaaacc ttgccaccaa cacgatgagt cggactgtct gctagcactt gctctggata
     6301 agcagtttct aactcgacca actcacggta aaggcggtca tactcactgt ctgaaaccga
     6361 gggattatcg ctggtatagt actcagtcgc atagcgattg agcaaagcga ctaactcatt
     6421 cattctttta ttcataagac cattttacca taaaacaagc cctcctcaca aacgagaagg
     6481 acggaaaaaa cacttagttt gaaattattt ttgaaactca agcaacctta tatcaatttt
     6541 tcaaaatgag ttcgaacata aataaacgat atacaagaca agatgataac accacttcca
     6601 attatcagga aagaagagag atgtacactt ggcaagactg tcataaatcc ttttgcaata
     6661 ggcataaata gaatagctaa ggtaaaaatt gtactcagta ctctcccaag aaattcgctc
     6721 tcaaccttgg tttgtacttg agtaaaaaag tgaatattaa aaatcgtcat aaacaattca
     6781 caaactaaat ttccagaaaa ggaaagaaaa gttggaagtg gtaatcccat cataaaaact
     6841 ccgacacctg tcaaagccag taaaatcaaa agattataaa tattagcttt aattttacta
     6901 gctagaagag ccccaatgat ggaaccaata gcccccatag ttaaaatact tgcataggct
     6961 ccttctgatc cgtaaagctg attcgaaaag ggaagtagaa attcaaaagc tgcaaaaaag
     7021 aaattaacgc tggaagctac cagcaaaagg aagaaaattt cttgctgatg ccagatatag
     7081 tgtaacccat ccttgatatc tacaaaaata tctctcccag taaaagcctt tttctcttga
     7141 acttttgctt cctcttttgg aaggaaagcc actagaacaa aagcaatgaa aaaagtcagc
     7201 gagtctagca gtagcgtcat atggagactt gcaaactgta aaacaaggaa ggaaagaaca
     7261 ggagagctaa cacctacaac ctgcaaaacc agctctaggc gagaattata gatcacaatc
     7321 tcatctttct ccaccacttc agttatgata gctttattgg ctgtgcgaga aaaggcaaaa
     7381 gcaatagcct gcacaatgtt agcaacaatc aaagcgccaa tcatccagct atcattcctt
     7441 atgaaagaaa tagccagaca aagaatccca caaacaagat ctgccgtcat taaaatctta
     7501 cgacgagaaa aacggtctga aataactccg ccaaagggat tgacgagaat agatgtgacg
     7561 agctcagaaa tctgatacat tcctaaaact gtctgtccta tagtccccat agaagccaac
     7621 cagacactat ttccataatc atagagcata tttcccattt tattgatagc cccacggcta
     7681 atcaactgca ctgcatagcg attcatatta aagctcctct caaattttga aactattgta
     7741 tcaaaaccga aaggagcttt ttattttttc ccttatttgg gaaaattaac ttttgacaaa
     7801 tttttcgtag tgttcctgat aataggctac ttgctctgga agacctaaca catcaaaaat
     7861 atgtatggcc tcttgcatct gcttacagcc ttctttacac tgtccttttt gatataaggc
     7921 aaaacctttt aaataatgga aaacattacg ctcataaagc ttaatacctt tgtcaataat
     7981 cttctctgta taagcctcaa aatagttggc attataaaaa gaagaatgct ctaaacaatg
     8041 ctggtaacaa ttgagggcca aaatcaaaac taatctctta tggcgactaa tctcttggta
     8101 aaattcctcc ctctccataa cttctctacc aatccgagtg acatagtcta catcgtagaa
     8161 actatagagg ttaccgaaaa gaatcaactc atacatggtc cattcttctg ttttgaagag
     8221 ataatctgct accttatcca aatcatcctg cttcatatca taactcgcat ctctttgaca
     8281 aatcagacct tgtagcaaaa tccagttcag ctcaaaataa aggggagtcg tcgaactctt
     8341 agacttttca agttgttctc tttgaagctt ttgaaaacct gcaatatcgt ttgaatagta
     8401 aagtgggata atctgtgcca tcatagacac atgttcatga ttgtgaaaat tccttgcctt
     8461 atccatgaaa ttttcgattg ttacatgaat gttatccaaa atctcaaaga aacgggagac
     8521 tgccaggtca gactccccaa gctcaaagcg agataactga gaggtagagc aggattcgcc
     8581 tgctgcttcc tttaaagaat aatttccact tgttcgaaat tcacgaaata cttttccaag
     8641 atgttccatc tttacacctg atctgataat tcttcccact caagcatagc ttcttcctga
     8701 cgatggctga ttttgtccag ctcagcctgt aattccatga gtttgtcggc atcgtttgtt
     8761 tccaacattt gttcagaaat ggcttggctt tgactttcta gctcttcaat ttcagcttct
     8821 agactttcga tttgtcgcat gagtttgcga acttcttttt gactttcttt ctgggcctga
     8881 tagtcattga ctggacttgc ttcctttgct tgattgctag ttgaagcttc ctcagtctga
     8941 ctcatttctg ctgttgcttt cttctcaaca tagtagtcgt aatctccaag gtagagagtt
     9001 gaaccattct cagacaattc caaaacatga gttgccacac gattgataaa gtaacgatca
     9061 tgactgacaa aaagcaaggt accatcaaag tcaatcaaag cattttccaa cacttccttg
     9121 ctatcaatat ccaagtggtt ggtcggctcg tcaaggatca ggaagttgtt gttttccata
     9181 gacaatttag ctaaaagcaa acgagctttt tcgccaccag atagcatgcc gactgatttt
     9241 ttaacatcat ctcctgagaa aaggaaggct ccaagacggt tgcggatttc aacttctggt
     9301 gtcagtttga aatcattcca gagttcatcc agcaccgtat tacttggtgt cagcttgctt
     9361 tgggtttggt catagtaacc aacctcaaca ttagcgccaa agcgcttttc acctttgata
     9421 aaaggaatct ggtccacaat agacttgata aaggttgact tgccgatacc atttggacca
     9481 acgatagcga cagcattcat cttacgaaga tctaggttga taggttgtga caagacttcc
     9541 ccgtcataac caatagcagt attttcaaca gtcaaaacaa cattgcccga cgttttttca
     9601 gactggaagg tcatgttggc tgctttcttg ccagcttcag gcttgtccaa acgctccatt
     9661 ttttctagtt gtttacggcg agattgagca cgtttagtcg ttgaagcacg aactagattg
     9721 cgattgacaa agtcttccag agcagcgatt tccttctgtt gcttttcata gttttttgcc
     9781 tcagtaacta gcttttgctc cttcaattcg acaaaacgag agtaattccc cacatagcga
     9841 tccaaggaat gcttggtcaa atctagcgta attgtcgcaa ccttgtccaa gaaataacgg
     9901 tcgtggctga cgataatgag ggcaccgcta tagtttacca agtaattctc tagccaggcg
     9961 atggtttcaa tatccaagtg gttagttggc tcgtccaaga ccaagagatt gggcttttca
    10021 aggagcattt tggcaagtgc caaacgagta ttttgaccac cagaaagctc agcaattttc
    10081 atctgccaca tagactcgtc aaacttgaat ccattcaaaa tcgctcgaat atcagcttca
    10141 taggtaaagc cacctgcttg gcgaaaattc tcagataagc ggtcataatc tgacatcagt
    10201 ttatccaaat cctcaccaga cttttcaccc atctccagct ccatctgacg cagttgtctc
    10261 tccgtccgac gcaaattatt aaagacatga agcatttcat cgtagatggt attttcagac
    10321 tcaaaacggc tatcttgggc taggtaagac agagaaatat cttttttctt attgatttct
    10381 ccgctagttg gctcctcttc tccaactaaa atcttcaaaa gagtagactt acctgcacca
    10441 tttttcccaa caagggcaat ccgatctcgt tcatcaacct gcaggttgat attatcgaaa
    10501 agaacctctc ctgcaaaaga acgttcaatt ttattagctt gtaaaataat cataagagta
    10561 gtatagcatg tttccctaag gcattcaaga taatcgtaag tcttttagta caacttttat
    10621 aacataaaat aaactaaatt atgtatattt tatattagat tcttcactat cttgttggat
    10681 tttctaacca gctaatcttg tttcaaatag ttatcgcaca agcctattat ttaattcttt
    10741 tcattattta cgtac
//
LOCUS       DBERMM010000054        10741 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.056, whole genome shotgun sequence.
ACCESSION   DBERMM010000054 DBERMM010000000
VERSION     DBERMM010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10741)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10741)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10741
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.056"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..268
                     /locus_tag="ACL8AS_001857"
     CDS             <1..268
                     /locus_tag="ACL8AS_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229666.1"
                     /translation="TYNQKLSLRGMNYKLNHEELNNFDLLKKMFLKLMETDKIENDIF
                     YLDGIKSILPLLSLDDRRNVLQHIQKQNNCPPPEIEELQRIIVN"
     gene            369..1247
                     /gene="truB"
                     /locus_tag="ACL8AS_001858"
     CDS             369..1247
                     /gene="truB"
                     /locus_tag="ACL8AS_001858"
                     /EC_number="5.4.99.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HGS1229667.1"
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGV
                     LPIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVIAETPVLSPLDEKLVDE
                     AIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDG
                     QLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALALEEIAE
                     KVEAGQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLA
                     ILEKRGNLYKPRKVFS"
     gene            1488..1790
                     /locus_tag="ACL8AS_001859"
     CDS             1488..1790
                     /locus_tag="ACL8AS_001859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HGS1229668.1"
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQS
                     VMANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            1898..2536
                     /gene="udk"
                     /locus_tag="ACL8AS_001860"
     CDS             1898..2536
                     /gene="udk"
                     /locus_tag="ACL8AS_001860"
                     /EC_number="2.7.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HGS1229669.1"
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYK
                     DQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQ
                     EPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQ
                     YLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            2664..4004
                     /gene="xseA"
                     /locus_tag="ACL8AS_001861"
     CDS             2664..4004
                     /gene="xseA"
                     /locus_tag="ACL8AS_001861"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA];
                     GO_function: GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA];
                     GO_process: GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HGS1229670.1"
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQY
                     FSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDG
                     VGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
                     PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVV
                     RAIFESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEK
                     RMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDN
                     KQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEVKRLSEALLM
                     LDTSRIVARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            3982..4194
                     /locus_tag="ACL8AS_001862"
     CDS             3982..4194
                     /locus_tag="ACL8AS_001862"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HGS1229671.1"
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKE
                     LQATLDKAEKTLVKVMQEDGTESDFE"
     gene            4191..5066
                     /locus_tag="ACL8AS_001863"
     CDS             4191..5066
                     /locus_tag="ACL8AS_001863"
                     /EC_number="2.5.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004659 - prenyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HGS1229672.1"
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRP
                     FLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFG
                     EAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
                     HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVL
                     DVTASFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFE
                     TESIVSVVESLRING"
     gene            5059..5874
                     /locus_tag="ACL8AS_001864"
     CDS             5059..5874
                     /locus_tag="ACL8AS_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="HGS1229673.1"
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPG
                     EKIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQ
                     NSAKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISL
                     SLILPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQNVLESVTAMAVEV
                     GFSVLGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            5867..6298
                     /locus_tag="ACL8AS_001865"
     CDS             5867..6298
                     /locus_tag="ACL8AS_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HGS1229674.1"
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRD
                     IKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVK
                     AQLIDTFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            6305..7972
                     /gene="recN"
                     /locus_tag="ACL8AS_001866"
     CDS             6305..7972
                     /gene="recN"
                     /locus_tag="ACL8AS_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HGS1229675.1"
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNM
                     MLGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGR
                     SISRVNGQMVNLSVLRAIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKET
                     YQTSFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLDLNQERDK
                     LLNHKNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYY
                     VLEDISKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEY
                     NLLTGNNLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKA
                     QFQVRFSKGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKE
                     GKTSIVFDEVDTGVSGRVAQAIAQKIHKIGQYGQVLAISHLPQVIAIADYQFFIEKIS
                     NDHSTVSTVRLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            7974..8702
                     /locus_tag="ACL8AS_001867"
     CDS             7974..8702
                     /locus_tag="ACL8AS_001867"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HGS1229676.1"
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSH
                     RVLEMVKDLVDNQGAICLSGNHEYMFLTWLDYPEESYDHYRRNGGDTTINSILGRPLD
                     APVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
                     WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLH
                     GIVFTDQGMTEHHFIENDGFVAED"
     gene            8781..10604
                     /gene="lepA"
                     /locus_tag="ACL8AS_001868"
     CDS             8781..10604
                     /gene="lepA"
                     /locus_tag="ACL8AS_001868"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation elongation factor 4"
                     /protein_id="HGS1229677.1"
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLA
                     ACEGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVI
                     GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQ
                     VRVMDGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQD
                     TRVGDTVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQ
                     FEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMD
                     VSNPSEFPDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVN
                     VIYQIPLAEIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFI
                     VHKDFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGG
                     DVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
BASE COUNT         3190 a         1925 c         2609 g         3017 t
ORIGIN      
        1 aacttataac cagaaattat ctttacgagg gatgaattat aaattgaatc atgaagaact
       61 taacaatttt gatttgttga aaaaaatgtt tctgaaatta atggagaccg ataaaataga
      121 gaatgatatt ttttatttag atggcatcaa aagtatactc ccattattat ctttagatga
      181 cagacgaaat gtattacaac atattcaaaa acagaacaat tgtcctcctc cagagattga
      241 ggaattacaa agaattatag ttaattaaat tttgtaaaaa agagaataaa aggtagacga
      301 cgcctcagta aaaattggcc cggaaaaaag cgaagttcga agcactgaag ggggagtaga
      361 aagcaaaaat gaacggtatt atcaacttaa aaaaagaagc aggaatgacc tcgcatgatg
      421 cggtttttaa actgcgtaag attttgggaa ccaagaaaat tggtcatggt ggaaccttgg
      481 atccggatgt ggtgggtgtt ttgccgattg cggttggcaa ggcgacacgc atggtcgagt
      541 ttatgcagga cgagggtaag atctatgagg gggaaattac tctgggttat tccacgacga
      601 ctgaggatgc tagtggggaa gtgatcgcag aaacccctgt tttgtctccc ttggatgaaa
      661 agcttgttga tgaagcgatt gctagcttga ctgggcctat tacccagatt ccccctatgt
      721 attcggcagt taaggttaat ggtcgcaagc tctatgagta tgcgcgtgct ggtcaggaag
      781 tggagcgtcc agaacgtcag gtgaccattt atcaatttga gcgaacaagt ccgatttctt
      841 atgatggcca acttgctcga ttcacttttc gtgtaaaatg cagtaaaggg acttacatcc
      901 gtactttgtc agttgatttg ggtgaaaagc ttggttatgc ggctcatatg tcccatttga
      961 ctcgtactag tgctgctggc ttacaattag aagacgctct tgccttggag gaaattgctg
     1021 aaaaagtaga ggctgggcaa ttagattttc tccatccttt agagattggg acaggtgacc
     1081 ttgtcaaagt tttcctaact ccagaagagg ctacagaagt tcgctttggt cgttttattg
     1141 agctagacca aacggacaaa gaactggctg cctttgaaga tgataaattg ttagccattc
     1201 tagaaaaacg gggcaatctc tataagccaa ggaaggtttt tagctagatc gtttaggaat
     1261 aaaaatcggg tgatagataa caattgcttg ataaaacccc atactaatag tagaatggtt
     1321 ttgggaatta taatattcca attgttgcga gttgtaggta ctcaaataat ctatatagaa
     1381 atttagaggt gtgaaatgaa gcaatttaaa attctttcag ataaatattt agagtccatt
     1441 acaggttctg gtgggaactt aggcccagga tttggtgtga taattccatg atgcgaaatg
     1501 agtttcgaga aagggtggag caacttcttc aacaaaaaga aataaatgaa aatagtgagt
     1561 tgagtcacct gtttcgtctt gctatacaaa atttagacag aaatgaaaaa taccaatcgg
     1621 tcatggccaa tttgagtcaa gggttgtcac tttacctcat gacgcatcat taccaggcac
     1681 ctaagtctgt cattgatttt ggtttatgga ttgccaaagc tcctagccag gaaagaggga
     1741 gactggcttt cttgcagatg cttgctcaaa ccctacaggg ctttcgttaa aactgtcgaa
     1801 catcagaggg aatactctgg tgttttttgc tgatgagact ataaattttg taaaaaatgt
     1861 gatagaatag acgacggata aaataacgga ggatagcatg caaaatagac caatcattat
     1921 tggagtgaca ggtggttctg gtggtggtaa aaccagtgtt tcaagagcca ttttatcgca
     1981 ttttcctgat gaaaagattt ccatgattga gcatgattca tactacaagg atcagtctca
     2041 tttgaccttt gaagagcgtg tcaaaaccaa ctatgaccat ccttttgcct ttgatacaga
     2101 cttgatgatc gagcagatta aggaattgtt ggcagggcgt ccggtggaca tcccgaccta
     2161 cgactataca gagcatacac ggagtagcaa gacctatcgt caggagcctc aagatgtctt
     2221 tatcgttgag ggcattttgg tcttggagga caagcgtctg cgcgatttga tggatatcaa
     2281 gatttttgtg gatacggatg acgatgtgcg cattattcgt cgtatcaagc gtgatatgga
     2341 ggagcgtggc cgtagccttg atagcgttat taaccagtac ttaggtgtgg tcaaaccaat
     2401 gtaccaccag tttatcgagt caactaagcg ttatgctgat atcgtcattc ctgaaggggt
     2461 tagcaatacc gtggctatcg acctgttgac gaccaagatt gcaaagattt tggaagaagc
     2521 tcgaaacagc aaataatcac atgtggaggc cttgcctcct ttttctattt ttccctcata
     2581 atggtacata aatggagatt tttaggcata tttttggtat aataataccc atgaaagagc
     2641 aagtaaatga atagtaggtg gagatggaaa agtatttatc ggtaacaact ttgaccaagt
     2701 atctgaaaat gaaattcgat aaagacccat acttggaacg ggtctattta actggtcaag
     2761 tttccaactt tcgtaaacga cctactcacc aatatttctc cctaaaggat gaccatgcag
     2821 ttattcaagc gaccatctgg tctgggattt atcagaaatt agggtttgac ctggaagaag
     2881 gaatgaagat caatgtgatt gggcgtgtac aggtttatga accaagtggt agctactcca
     2941 tcatcattga aaaagctgag cctgatgggg ttggggcgct tgcgattcag tttgaacaac
     3001 ttaagaaaaa attgacagaa gaaggcctgt ttcaagaacg cttcaagcaa gctctgcccc
     3061 aattttctaa gagaattggg gtagtaacca gccgtagtgg agccgttatt cgagatatta
     3121 tcacgaccgt cagcaggcga ttcccaggtg ttgacatcct tctttatccg accaaggttc
     3181 aaggtgaagg ggctgcggag gaaattgcta gaaatattgc gcgtgctaat caacgggatg
     3241 atttggattt gctcattatt ggtcgtggag gtggttctat tgaggatctc tgggccttta
     3301 acgaagaaat tgtggtacga gctatttttg aatctcgttt gccagttatc tctagtgtgg
     3361 ggcatgagac ggatgtgacc ttggcagatt ttgtggcaga tcgacgcgct gcaacgccaa
     3421 cagcggcggc tgaactggca acacctgtga ccaagttgga tgtattagct catttgcaaa
     3481 atcaggaaaa acggatggta acggcagtcc gaaatgttct atctaagaaa caagaggctt
     3541 tgaaaaaatg cagtcagtct gttatcttta gacaacctga gcgcttgtat gacggttatt
     3601 tgcaacgctt ggaccaactg caactgcgtt tgaaacaaag tttgcgaact cggatttctg
     3661 ataacaaaca attagttcaa gcaagaactc atcaattagt acaattatca cctgttacca
     3721 aaatccaacg ctatcaagac cgtttaggac agttggacaa gctcttaggt agccaaatgg
     3781 cgttagttta tgacgccaag gttgctgagg tcaagcgact ttcggaagct ttgctcatgt
     3841 tggatactag ccgaatcgtg gcgcgtggtt atgctattgt caaaaaagaa gagtccgttg
     3901 tagattcggt tgagagtttg aagaaaaaag accaagtaac gcttttgatg cgagatggtc
     3961 aagtagaatt agaggttaaa gatgtcaaaa caaaagaaat ttgaggaaaa tctagcagaa
     4021 ctggaaacca ttgtccaaag tttggaaaat ggtgaaattg ctctggaaga tgcgattact
     4081 gcctttcaaa agggcatggt cttgtcaaaa gagctccaag ctacgctgga caaggctgaa
     4141 aagaccttgg tcaaggtcat gcaagaagac ggaacagaaa gtgattttga atgaaaaagc
     4201 aagaaaaatt agctcttgtc gagtcggctt tggaagattt ttatggagac cagcagtttg
     4261 cctctagttt acgggagtct gttctctatt ctattcatgc tggtggcaag cgtattcggc
     4321 cttttctctt gttagaagtt ctggaagcct tgcaggttac catcaaacct gctcacgcgc
     4381 aggtagctac tgccttggag atgattcata cagggagctt gattcacgat gaccttcctg
     4441 ctatggatga tgacgattat cgaagagggc ggttaaccaa tcacaagaaa ttcggtgaag
     4501 ctatggccat tttggctgga gatgccttat tcttagactc atatgccttg attgcgcagg
     4561 cagatttgcc aagtcagatt aaggtggact tgattgccaa cttatccctt gcttcaggta
     4621 gtctgggtat ggtggcaggg caagttttgg atatggaggg cgaacaccag cacttgtctt
     4681 tggaagaact tcagactatt catgccaata agactgggaa gttactagcc tatcccttcc
     4741 aagcggcagc tattatagct gaattgtcac ctgaaatgca ggtgaagctg aaaactgtgg
     4801 gtgaattgat tggacttgct tttcaagtta gagatgatgt actggatgtg acagctagtt
     4861 ttgaggaaat cggcaagaca cctcaaaagg atctgcaggc agaaaaatca acctatcctg
     4921 ccctgttggg cttggaagag tccattgcct tttgtaacca aaccctggat caagctaatg
     4981 aaaaattaga agaaattgcc cagcagattc cctttgaaac agaatcgatt gtaagtgtag
     5041 tagaaagttt gagaatcaat ggctaaggaa agagtggatg tactagctta taaacagggc
     5101 ttgtttgaaa cgagagagca ggccaagcga ggtgtgatgg ctggcctagt cgtagcagtc
     5161 cttaatggag aacggtttga caagccagga gagaaaattc cagatgacac cgaattaaaa
     5221 ctcaaggggg agaaactcaa gtatgtcagc cgtggtggtt tgaaactgga aaaggccttg
     5281 caggtctttg atttgtcggt ggatggcgcg actacgattg atatcggggc ctctactgga
     5341 ggttttaccg atgtcatgct acagaatagt gccaagttgg tctttgcagt cgatgttggt
     5401 accaatcagt tggcttggaa attacgccaa gacccacgag ttgtcagtat ggagcagttc
     5461 aatttccgct atgctgaaaa gactgatttc gagcaggagc cgagctttgc cagtattgat
     5521 gtgagtttca tttcccttag tctgattttg ccagccttgc accgtgtctt ggctgatcaa
     5581 ggtcaggtgg tagcacttgt caaacctcag tttgaggcag gacgtgagca gattgggaaa
     5641 aatggaatta ttcgagatgc taaggttcat cagaatgtcc ttgaatctgt aacagctatg
     5701 gcagtagagg taggtttttc agtccttggc ttggactttt ctcccatcca aggtggacat
     5761 ggaaatattg aatttttagc gtatttgaaa aaagaaaagt cagcaagcaa tcagattctt
     5821 gctgagatta aagaagcagt agagagggcg catagtcaat ttaaaaatga ataaaaaaga
     5881 gagacttgaa aaaattagaa gattggtgac agattatcaa atcggcacgc aagaagaaat
     5941 tgtagaacat ttgaaagaag caggtatcac tgccactcag gcgacggtat cccgagatat
     6001 caaagagtta ggtattgtca aaattccttt gagagacaac acctatgtct acgaattgcc
     6061 aaaatcaatc gtaaaaagtc tgcaactggc tgaagacaat atcgaatcgg ctgaattgat
     6121 ggataagatg atcaatctcc aagttattcc aggaaatacg gcttttgtaa aagctcagtt
     6181 aatcgatact tttgcagaca agatttttag ttgtttgact gatgatagct cgattttagt
     6241 cattgccaga agtggaagtc tagcagagga aatctttgaa caagtaaaaa attggtaggt
     6301 ctatatgtta cttgaaattt cgataaaaaa ctttgccatt attgaggcta tttccctcaa
     6361 ttttgaaaag gggatgactg tcctgactgg tgaaacgggt gcagggaagt cgattatcat
     6421 tgatgccatg aatatgatgt tgggagctcg tgcgacgaca gatgttattc gtcatggtgc
     6481 accaaaggca gagattgagg ggcttttctc agttgagaat agtcgtcttt tacaggaaat
     6541 ttttgatgag caaggtttag agttaggtga tgaaattatc atccgtcggg aaatcttgca
     6601 aaatggtcgt agtatcagcc gtgtaaatgg tcagatggtt aatctgtctg ttttgcgagc
     6661 tattgggcaa catcttgtag atattcatgg tcagcatgac catgaggagt taatgcgtcc
     6721 ccaactgcat atccagatgt tggatgaatt tggtgatgcc gctttttggg acttgaaaga
     6781 aacctatcaa acgagttttg atgcctatcg gaaaatgcgc aagcaggttc tggaagtcaa
     6841 gaaaaaccaa caggaacaca aggcacgtat cgaaatgtta gaatttcaaa tggcagagat
     6901 tgaggcagca aacttgcagg ctggagaaga cttggatctc aatcaagagc gagataaact
     6961 cctcaaccac aaaaatattg cggatacact gaccaatgcc tacagtatgt tggacaatga
     7021 agatttttca agtctggcca atgttcgttc agccatgaat gacatggaaa gtgtcgaaga
     7081 gtatgaccct gaataccgtg aaatttcaag ctctctgtct gagacctact atgttttaga
     7141 agacattagc aaacgtttgg aagctatcat tgaggacctt gattttgatg gcaatcgcct
     7201 catgcaggtt gagaatcgtt tggacctcct tcatactatt actcgtaagt atggtgggac
     7261 tgttgatgat gttttgcttt attttgccaa gattacggaa gaatacaatc tcttgacagg
     7321 caataatctt tcgtctgagg acatggaagc agagcttaag aagttggaag tcaatcttgt
     7381 caatttggca ggtcaacttg cttctgctcg tcataatttg gctcagcaac tcgaagctga
     7441 gattaaacaa gaactgcaag atctttatat ggaaaaagcc cagtttcagg ttcgttttag
     7501 taagggaaaa ttcagtcgtg agggaaatga aatggttgag ttttatattt caaccaaccc
     7561 tggagaagac tttaaaccct tggttaaggt tgcttctgga ggggaattat ctcgtctcat
     7621 gttagccatt aagtctgcct tttcacgtaa agaaggcaag actagcattg tctttgatga
     7681 ggtggatacg ggagtttcag gtcgtgttgc tcaagctatt gctcagaaaa ttcataaaat
     7741 tggtcagtat ggtcaggttt tggctatctc ccatttgcca caagtaattg cgattgcaga
     7801 ttatcaattc tttattgaga agattagtaa tgaccattca acggtttcga ctgttcgtct
     7861 cttgacagtc gaagagcgag tggaggaagt tgccaagatg ttggcaggtg atgatgtgac
     7921 agaagcagcc ctgacgcaag ccagagaatt gttgagaaac agggagaaat aagatgacag
     7981 attattatgt aattggagat gttcacggaa aagctgggat gctggaagac cttcttaaaa
     8041 cctgggatgg tcagacccag ttgctctttc taggtgattt gattgacaga ggtgaggata
     8101 gtcaccgtgt tcttgaaatg gtcaaggact tggtggacaa tcaaggggct atctgtttgt
     8161 ctggaaacca cgagtatatg tttttgactt ggctagatta cccagaagaa agttatgacc
     8221 attatcgtcg caatggtgga gatacaacca ttaactctat cctaggtcgt cccttggatg
     8281 caccagttga tggagtagaa gatgccaagc gggttgccgc tgaagcggca gacttggtcg
     8341 aattcattcg tcaaatgcca tttgtagtag agacagacaa gtatatcttt gttcacgcag
     8401 gtattgattt gaccttggac gactggcatg aaacaacaga ttataaaaaa gtatggctta
     8461 gaaaaccatt ccacggagct gaaaatcata ctggaaaaac cattgtcttc ggtcatacac
     8521 cggtctatgg tttgttacag caagaacgcg gtacatctga gctttggact acagaagatg
     8581 gcaagattgg aatggatgga ggagctgttt atggtggtgt ccttcacggg attgtcttta
     8641 cagaccaagg aatgacagaa caccacttta tcgaaaatga cggctttgtc gctgaagatt
     8701 agtactccta gcagggtatg gtcttgtcaa aatatcaaaa acaatttata ataaatagat
     8761 accctgaaag gaagagaatc atgaacttag aagaattgaa aaaacgacag gagaagatcc
     8821 gtaacttctc tattatcgcc catattgacc acggaaaatc aactctagca gaccgcattt
     8881 tggaaaaaac agagacggtt tcaagtcgtg aaatgcaggc ccagcttttg gatagcatgg
     8941 atctagagcg ggaacgtgga attactatta agttgaatgc catcgagttg aattacactg
     9001 caaaagatgg ggaaacttat attttccact tgattgacac accagggcac gttgacttta
     9061 cctatgaagt ttcacgttcg ctagctgcct gtgagggtgc tattttggtg gtcgatgcgg
     9121 ctcaaggaat tgaggctcaa actcttgcca acgtttatct agctttggat aatgatttgg
     9181 aaatcatgcc tatcattaat aaaattgacc tgccggctgc agatccggag cgcgtgcgta
     9241 cagagattga agatgtgatt ggtttggatg ccagtgaagc agttttggct tctgccaagg
     9301 ctggtattgg gattgaagaa atcctcgagc aaattgtaga aaaagtacca gcaccaacgg
     9361 gtgatgtgac ggcgccactt aaggccttga ttttcgactc tgtttacgat gcttaccgtg
     9421 gggttatcct acaagtgcgt gtcatggacg gagtggtcaa acctggtgat aagattcagc
     9481 tcatgagcaa tagtaagacc tttgatgtgg ccgaagtcgg tatttttaca ccaaaagcgg
     9541 ttggtcgtga tttccttgcg actggtgatg ttggttacat tgcggcgtct atcaagacgg
     9601 ttcaggatac tcgtgtgggt gataccgtta ccttggcaac caatcctgcg gcagaaccat
     9661 tacatggtta taagcagatg aatcctatgg tctttgcggg tctctaccca atcgaatcaa
     9721 acaagtacaa tgacctgcgt gaagcgcttg aaaaattgca actgaatgat gctagtcttc
     9781 agtttgaacc agaaacatct caggcacttg gatttggttt ccgttgtgga tttcttggac
     9841 ttctccatat ggatgttatt caggaacgtt tagagcgtga gttcaatatt gacctcatca
     9901 tgacagctcc gtctgttatt tacaaagtta atttgaccga cggtgagtct atggatgtgt
     9961 ctaacccatc tgagtttcca gacccaacta agattgcgac cattgaagag ccttatgtca
    10021 aggcgcaaat catggtacca caggagttcg tcggagcagt aatggagcta gctcagcgta
    10081 agcgtgggga ctttgtgact atggactata ttgatgataa ccgtgtcaat gttatctatc
    10141 aaattcctct tgctgaaatt gtctttgact tctttgataa acttaagtct tcgacacgtg
    10201 gttatgcaag ctttgactac gaattatcag aatatcgccc atctaagctg gtgaaaatgg
    10261 atatccttct caatggagat aaggtggatg ccctcagctt tatcgttcac aaggactttg
    10321 cctacgaacg tgggaaactc atcgttgata aactcaagaa aatcatccct cgccaacaat
    10381 ttgaagttcc aatccaagcg gctattggac acaagattgt cgctcgtact gatatcaagg
    10441 cccttcgtaa gaacgtactt gctaaatgtt atggtggtga cgtttctcgt aagcgtaaac
    10501 tccttgaaaa acaaaaagct ggtaagaaac gcatgaaatc catcggatca gttgaagttc
    10561 cgcaagaagc cttcctcagc gtcttgagta tggatgaaga ataagttatc agaaatgcct
    10621 ttccttgttc acaggaaatt tatataagaa tcaatagtaa agcaggctta gatggtctgc
    10681 ttttttagtt tttatactct tcgaaaatct cttcaaacca cgtcatcgtc gccttaccgt
    10741 a
//
LOCUS       DBERMM010000055        10491 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.057, whole genome shotgun sequence.
ACCESSION   DBERMM010000055 DBERMM010000000
VERSION     DBERMM010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10491)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10491)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10491
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.057"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            159..938
                     /locus_tag="ACL8AS_001869"
     CDS             159..938
                     /locus_tag="ACL8AS_001869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229678.1"
                     /translation="MAEQDLAMQVLQQVVKLPVVKVDRSKFLVDKFSKELGPQDIPTL
                     LEQGPTSLLSQEILDRVANACIRDNVLLASGTSVLAGLPGGLAMAITIPADVAQFYTF
                     SLKLAQELGYIYGYEDLWASREELSEDAQNTLLLYLGVMLGVNGTAALLRAGGITIAK
                     QVMKTVPNKALTKTLWYPILKKVLKIFGVNLTKGGLAKGIGKFIPILGGIISGGLTFA
                     TMKPMGESLQKELSKLVNYSEVQYQEDVETIRKEAEIIEGE"
     gene            940..1122
                     /locus_tag="ACL8AS_001870"
                     /pseudo
     CDS             940..1122
                     /locus_tag="ACL8AS_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522940.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            1119..1271
                     /locus_tag="ACL8AS_001871"
     CDS             1119..1271
                     /locus_tag="ACL8AS_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229679.1"
                     /translation="MKFFWGLLAIIFIKPIIGIVKFFWMIISFAVQLLFYKIVFKILD
                     WLFKLI"
     gene            complement(1401..1553)
                     /locus_tag="ACL8AS_001872"
     CDS             complement(1401..1553)
                     /locus_tag="ACL8AS_001872"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229680.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEVVDRTDEVSSKHRFEVVDRTDEVS
                     NIYTAR"
     gene            1584..1817
                     /locus_tag="ACL8AS_001873"
     CDS             1584..1817
                     /locus_tag="ACL8AS_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1858 domain-containing protein"
                     /protein_id="HGS1229681.1"
                     /translation="MDNIIDVSIPVAEVVDKHPEVLEILVELGFKPLANPIMRNTVGR
                     KVSLKQGSKLAGTPMDKIVRTLEANGYEVIGLD"
     gene            1817..3151
                     /locus_tag="ACL8AS_001874"
     CDS             1817..3151
                     /locus_tag="ACL8AS_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000752887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF438 domain-containing protein"
                     /protein_id="HGS1229682.1"
                     /translation="MTDERIHILRDILLELHNGASPESVQERFDATFAGVSAIEISLM
                     EHELMNSDSGVTFEDVMELCDVHANLFKNAIKGVEVLDTEHPGHPVRVFKEENLALRA
                     ALIRIRRLLDTYESMEDEEMLAEMRKGLVRQMGLVGQFDIHYQRKEELFFPIMERYGH
                     DSPPKVMWGVDDQIRELFQTALTTAKSLPEVSISSVKEAFEAFATEFESMIFKEESIL
                     LMILLESFTQDDWLQIADESDAYGYAIIRPSEKWVPERQSFIEEKIAEEPVQLDTAEG
                     QVQQVIDTPEGHFTITFTPKEKEAVLDRHSQQAFGNGYLSVEQANLILNHLPMEITFV
                     NKEDIFQYYNDNTPADEMIFKRTPSQVGRNVELCHPPKYLDKVKTIMKGLREGTKDKY
                     EMWFKSESRGKFVHITYAAVHDEDGEFQGVLEYVQDIQPYREIDTDYFRGLE"
     gene            3161..3415
                     /locus_tag="ACL8AS_001875"
     CDS             3161..3415
                     /locus_tag="ACL8AS_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1912 family protein"
                     /protein_id="HGS1229683.1"
                     /translation="MSYEQEFMKEFEAWVNTQIMINDMAHKESQKVYEEDQDERAKDA
                     MIRYESRLDAYQFLLGKFENFKAGKGFHDLPEGLFGERNY"
     gene            3511..3906
                     /locus_tag="ACL8AS_001876"
     CDS             3511..3906
                     /locus_tag="ACL8AS_001876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HGS1229684.1"
                     /translation="MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQSAS
                     AAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFK
                     NWTEKELLALKGIGPATIKKLKENGIKFK"
     gene            4432..4767
                     /locus_tag="ACL8AS_001877"
     CDS             4432..4767
                     /locus_tag="ACL8AS_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229685.1"
                     /translation="MSHQEKLERLGVHYEISERTQIPILDACPLVLDCRVDRIVEEDG
                     ICHIFAKILERLVAPELLDEKGHFKNQLFAPTYFMGDGYQRVYRYLDKRVDMKGSFIK
                     KARKKDGKN"
     gene            4754..5314
                     /locus_tag="ACL8AS_001878"
     CDS             4754..5314
                     /locus_tag="ACL8AS_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000124561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family protein"
                     /protein_id="HGS1229686.1"
                     /translation="MARTELPDKIETERLVLRVRTVADAEDIFDYASLPEVAYPAGFP
                     PVKTLEDEIYYLEHILPERNQKENLPAGYGIVVKGTDKIVGSIYFNHRHEDDVMEIGY
                     TLHSDYWGRGYVPEAARALIDLAFKDLGLHKIELTCFGYNLQSQRVAEKLGFTLEARI
                     RDRKDAQGNCCDDLRYALLKSEWEVI"
     gene            5314..5892
                     /locus_tag="ACL8AS_001879"
     CDS             5314..5892
                     /locus_tag="ACL8AS_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000550018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HGS1229687.1"
                     /translation="MHLFIIGAPASGKMTIGQELSRLTDATLFYNHQAIDFALEIYQD
                     YTEEMWEFVRGITFSFLGASARNQRSVILTDVIDFSNQYQLMYLKQIQNLLDDYHQEI
                     LFVELETSLEECIRRNRTENRLKHKPLKRHIEVSEREILETAETLQLNSQYQPNELHH
                     YFKINNTNLSAEEAAKQIQNKINKIEKGHTHV"
     gene            5885..8536
                     /locus_tag="ACL8AS_001880"
     CDS             5885..8536
                     /locus_tag="ACL8AS_001880"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0004832 - valine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006438 - valyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HGS1229688.1"
                     /translation="MSKELSSKYNPADVEAGRYQKWLDADVFKPSGDQKAKPYSIVIP
                     PPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEG
                     ITRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVF
                     VDLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVAT
                     TRPETMFGDVAVAINPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPEFGTGVVKIT
                     PAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVVAKLEEIGALV
                     KIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDT
                     FLQWMENVHDWVISRQLWWGHQIPAWYNADGEMYVGEEAPEGDGWTQDEDVLDTWFSS
                     ALWPFSTMGWPEVDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVL
                     IHGLIRDEQGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDA
                     SWNFINKIWNISRYILMNNGGLTLDVAHDNVTKVATGEAGNVTDRWILHNLNETIAKV
                     TENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEEEKVITRSVLLYTLDKI
                     LRLLHPIMPFVTEEIFGQISEGSIVTAAYPTVNLAFEDLAAHTGVESLKDLIRAVRNA
                     RAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSS
                     VITGAEIFLPLADLLNVEEELARLDKELAKWQKELDMVGKKLSNERFVANAKPEVVQK
                     EKDKQADYQAKYDVTVARIDEMKKLVK"
     gene            8606..9360
                     /locus_tag="ACL8AS_001881"
                     /pseudo
     CDS             8606..9360
                     /locus_tag="ACL8AS_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033780.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3883 domain-containing protein"
     gene            9641..10444
                     /locus_tag="ACL8AS_001882"
     CDS             9641..10444
                     /locus_tag="ACL8AS_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HGS1229689.1"
                     /translation="MQPTYNIDNPNLSYEAKRDLWRIGFGLQKVDNLVPSAYMESLAE
                     KQARGELTYEQVYEDATAYHHTIDASTEEADLVSLRIVELLSRRGFSFSPATLLAIHK
                     ELFQDIFEPSIPVGQFRQTNITKNEPVLNGESVVYSDYSMIQMTLDYDFNQEKQVAYA
                     TLTQADMVKKIQHFISGIWQIHPFREGNARTVTVFLIQYLREFGFDIDNIPFQQHSKY
                     FRDALVLDNAKILQRRPEFLTAFFENLLLGGQNDLSSEKMYLDLDLDFS"
BASE COUNT         3149 a         1951 c         2352 g         3039 t
ORIGIN      
        1 gaaatcgatt tgactgtcct gatcgatttg tcctgttctt gtttcatttc actataaaaa
       61 aggggttctg tattttttaa tgttatctaa ttagaaaatg ctttttttgt aggaaatata
      121 atatgataag gtgcaaaaaa gaaataagga gtttgtatat ggctgaacaa gacttagcta
      181 tgcaagtatt gcaacaagtg gtgaaactac ctgttgttaa ggttgatcgt tcgaaatttt
      241 tagtggataa gttttccaaa gaattgggtc cacaggacat tcctacctta ttggaacaag
      301 gtccaacgtc tctcttatct caagaaatct tagatcgagt ggctaatgcc tgtattaggg
      361 ataatgtttt attagcgagt gggacttctg ttttggcagg attacctgga gggcttgcta
      421 tggcaattac cattccagct gatgtggctc aattttatac tttctctcta aaattggctc
      481 aagaattagg ttatatttat ggttatgagg atctttgggc ttcacgcgag gagttgagtg
      541 aagatgctca aaataccctc ttgctttatc taggcgtcat gttgggggtg aatggaaccg
      601 ctgctttgct acgtgctggt ggtataacaa ttgccaaaca ggtaatgaaa acagtgccta
      661 ataaagcttt aacaaagacg ctttggtacc ctattttgaa aaaagtctta aaaatatttg
      721 gtgtgaatct taccaaggga gggctggcca aaggaatagg gaaatttatt cctatcttgg
      781 gtggtatcat ttcaggtggt ttaacctttg caactatgaa accgatgggt gaaagcttgc
      841 agaaagaatt gtccaagcta gttaactata gtgaagttca atatcaagaa gatgttgaaa
      901 caatccgaaa agaggctgaa atcatcgaag gagagtaata tgggactcat aaaaactcta
      961 gctaaaattt atggtaatta ctttttgacc gtgtaaggtg taaaagtaat gaaaacgata
     1021 aagaaagatg ataatgccgt tgtcggtctg gggaaacttt ttattgccga caagttaatg
     1081 gatacggctc ggtggctcat taagccagag gataaaaaat gaaatttttc tggggacttc
     1141 ttgccattat ttttatcaaa ccgattattg ggattgtgaa attcttttgg atgatcatct
     1201 cttttgcagt ccaattgctg ttttacaaga tagtgtttaa gatattggat tggctcttta
     1261 aacttatcta gatggtaatc caagtcgcag agaactagca ggaactccac tgctagtttt
     1321 ttattctctt tccatatggt ataatataag cagtaaaatc attttatact cttcgaaaat
     1381 ctcttcaaac cacgtcagct tcaccttgct gtatatatgt tactgacttc gtcagttcta
     1441 tccacaacct caaaacggtg ttttgagctg acttcgtcag ttctatctac aacctcaaag
     1501 cactgttttg agcaacctgc ggctagcttc ctagtttgct ctttgatttt cattgagtat
     1561 tagaacatac aatggaggtc gtcatggaca atatcatcga tgtgtcaatt cctgttgcag
     1621 aagtggtgga caagcatcca gaagtcttgg aaattctagt ggagttgggt tttaaacccc
     1681 ttgccaatcc cataatgcgc aatacagttg gtcgtaaagt atcacttaaa cagggttcta
     1741 agctagcagg aactcctatg gacaagattg tacgcacact ggaagcgaat ggctacgaag
     1801 tgattggatt agactaatga cagatgaacg gattcatatc ctacgggata ttttgttaga
     1861 attgcacaat ggcgcctctc ctgagtcggt tcaggagcgt tttgatgcga cctttgcggg
     1921 tgtctcagcc attgagattt cccttatgga gcacgagctg atgaactcag actcaggtgt
     1981 cacctttgaa gatgttatgg aactctgtga tgtccatgcc aatcttttta aaaatgctat
     2041 caaaggtgtc gaagttttag ataccgaaca ccctgggcac ccagttcgtg tctttaagga
     2101 agaaaatttg gccctccgtg cagctttgat tcgcattcgt agattgttag atacctatga
     2161 gtctatggaa gacgaggaaa tgcttgcgga gatgcgcaag ggcttggtgc gtcagatggg
     2221 acttgtgggg caatttgaca tccattacca acgtaaggaa gaactcttct ttcctatcat
     2281 ggagcgctat ggacacgatt cacctcccaa agttatgtgg ggagtggatg atcagattag
     2341 ggaactcttt caaacagctc taacgacagc caagtcacta ccagaagtgt caattagcag
     2401 tgtaaaggaa gcttttgaag cttttgcgac agagtttgaa agtatgattt tcaaggaaga
     2461 gtccatcctc ctcatgattc tccttgagtc ttttactcag gatgactggc ttcagattgc
     2521 ggatgagagc gatgcctatg gctatgccat catccgtccg tcagagaaat gggtgccaga
     2581 acgacagagc tttattgagg aaaagattgc agaggagcct gtacagctag atacggcaga
     2641 aggtcaagtt caacaagtca tagatacgcc agaaggccat tttaccatta cctttacccc
     2701 taaggaaaag gaagctgtgc tggaccgcca tagtcaacag gcttttggta atggctatct
     2761 ttcagtcgag caggccaatc tcatcctcaa tcatctccct atggagatta cctttgtcaa
     2821 taaagaagat attttccagt attacaatga caatacgcca gctgatgaga tgattttcaa
     2881 acggacgccg tcccaagtcg ggcgcaatgt cgaactctgt catccgccta agtatttgga
     2941 caaggtcaaa actatcatga aggggcttcg tgaggggacc aaggacaagt atgaaatgtg
     3001 gttcaagtct gagtcgcgag gtaagtttgt ccacatcacc tatgctgcag tacacgatga
     3061 agacggagaa ttccaaggag tgttggagta tgttcaggat atccagccct accgtgagat
     3121 tgatacggac tattttcgtg gattagaata aggagaaaaa atgagttacg aacaagaatt
     3181 tatgaaggaa tttgaagctt gggtcaatac ccaaatcatg attaacgaca tggcgcacaa
     3241 ggaaagtcaa aaagtttacg aagaagacca ggacgagcgt gccaaagatg ccatgattcg
     3301 ctacgagagt cgcttggatg cttatcagtt cttgcttggt aagtttgaaa acttcaaagc
     3361 aggcaaggga ttccatgatt tgccagaagg cttgtttggt gagcgaaatt attaaacgag
     3421 aaagattctt gatttttcac taaaatcttg atagaatgtt tatgttaaat ccttgtcaga
     3481 gcagggattt tttattgaaa ggattttatc atgtcaaaga aactcaatcg taaaaaacaa
     3541 ttacgaaatg gcctccgtcg cgcaggtgcc ttttcaagta ctgtgactaa ggttgtagat
     3601 gagacaaaaa aagtcgtgaa gcgtgcagaa cagtcagcaa gcgcagctgg taaggctgtt
     3661 tctaaaaaag ttgaacaagc agtagaagct accaaagagc aagctcaaaa agtagctaat
     3721 tctgtagaag attttgcagc aaacttgggt ggacttccac ttgatcgtgc caaaactttc
     3781 tatgatgaag gaatcaagtc tgcttcagat ttcaaaaact ggactgaaaa agaactcctt
     3841 gccttgaaag gaatcggccc agctaccatc aagaaattga aagaaaatgg catcaagttc
     3901 aagtaatttt tcttgagcct tgcatttccg agaaaaactt gctacaatag agccattaga
     3961 ggtgttttga atcccacatt ttacagaaag tggcggcgct gagaagtcca caaatgtgtc
     4021 aaaactggtt gctaatgact gaaaaaatga aatatttctg tctttttatt ttaaagacta
     4081 aagatgcggg cttggcccga aattgggtgg taccgcggat aaacacattc gtccctgtca
     4141 tgtagatggc agggcttttc ttttgtgtct tagtcaaagg aggttgttat aaaacaatca
     4201 tttaaaacta ataaactata ttatggtttt cctgttttta ttttaggata tcaagattag
     4261 aattttggct ataacatcac gacctgtagt tcctcttata gtctaggaga ttgggttgtg
     4321 attggagtcg ttgcgagaga gaatgccgca gagcagatca aacagtatca aaaatttact
     4381 gtgaatattt ctgatgaaac ttctatgctt gcgatggagt aggctggttt tatcagtcat
     4441 caggagaaat tggaacgttt gggagtgcat tatgaaattt ctgaacgaac tcagattcct
     4501 attttagacg cctgtccact tgttttagat tgtcgggtag ataggattgt tgaggaagac
     4561 ggtatttgcc acatctttgc caagattctt gagcgacttg ttgccccaga actcctggat
     4621 gaaaagggac attttaaaaa tcaactgttt gccccaacct atttcatggg agatggatat
     4681 cagcgcgttt atcgctatct ggacaagcgt gtagatatga agggcagttt catcaaaaaa
     4741 gcgaggaaga aggatggcaa gaactgagct gccagataaa atcgaaacag aacgtctcgt
     4801 tttacgagtc cgtactgtgg cggatgctga ggatatcttt gactatgcta gtttgccaga
     4861 ggtcgcctat ccagcaggtt ttcctccagt caagaccttg gaagatgaga tttattatct
     4921 ggagcacatt cttccggagc gtaatcaaaa ggaaaatctc ccagcaggct acgggattgt
     4981 cgtcaaagga acggataaga tcgttggctc tatctatttc aaccatcgcc atgaagatga
     5041 tgtgatggaa atcggctata ccttacactc agactattgg gggcgaggtt atgtgccaga
     5101 agctgcgcgt gccttgattg acttagcctt taaagatttg ggtcttcaca agattgaact
     5161 aacttgcttt ggatataacc ttcaaagtca acgagtcgcg gaaaagcttg gctttaccct
     5221 cgaagctcgc ataagagacc gtaaagatgc tcaaggcaac tgctgtgatg atttgagata
     5281 tgccttgctg aagagtgagt gggaggtgat ttgatgcatc ttttcatcat tggtgctcca
     5341 gcatcaggaa aaatgaccat tggtcaagaa ttatctcgac tgacggatgc taccctattt
     5401 tataaccatc aagccattga ttttgcacta gaaatctatc aggactatac agaggaaatg
     5461 tgggaatttg ttcgtggaat cactttttca ttccttggag caagtgcaag aaatcagcga
     5521 tcagtaattt taacagatgt aattgatttt tcaaatcagt atcagctgat gtatttaaag
     5581 caaattcaga atttgttgga tgattatcat caagagattc tttttgttga gttggaaaca
     5641 agtcttgaag agtgcatacg tcgaaatcga acggagaatc gattaaagca caaaccctta
     5701 aaacgacata ttgaggtatc tgaaagagaa attttagaga ccgctgaaac acttcaatta
     5761 aattcccaat atcaaccgaa tgagttgcac cactacttta aaataaataa tacgaatttg
     5821 tctgcagaag aagctgctaa gcaaattcaa aataaaataa acaaaataga gaaaggacac
     5881 acacatgtct aaagaacttt catctaaata caatccagcc gatgttgagg ctggtcgtta
     5941 ccaaaaatgg cttgatgcgg atgttttcaa gccttcaggc gatcaaaagg ctaagcctta
     6001 ttcaatcgtg attccaccac caaacgtaac tgggaaactt caccttggtc acgcttggga
     6061 tacgactttg caggatatca tcatccgtca aaaacgcatg cagggctttg ataccctttg
     6121 gcttccaggt atggaccacg ctggtattgc gactcaggct aaggttgagg agcgcttacg
     6181 tggtgagggt attacgcgtt atgacctagg tcgtgagtct ttcttgacga aggtctggga
     6241 atggaaagac gaatatgcca ctaccatcaa ggaacaatgg ggcaagatgg ggctttctgt
     6301 agactattct cgtgagcgtt tcactcttga cgaaggtttg tcaaaagctg ttcgtaaggt
     6361 ctttgtggac ctttacaaga aaggctggat ctatcgtggt gagtttatca tcaactggga
     6421 cccagcagct cgcacagccc tttctgatat tgaggtgatt cacaaggatg tagaaggtgc
     6481 cttctaccac atgaattaca tgctggaaga tggttcacgc gcccttgaag ttgctacaac
     6541 tcgtcctgag actatgtttg gggacgttgc ggttgcgatt aatccagaag acccgcgcta
     6601 caaggacttg attggtaaaa acgtcatcct tccaatcgct aataaactca tcccaatcgt
     6661 tggagatgag cacgcagatc ctgagtttgg tactggtgtc gtgaaaatca cacctgccca
     6721 cgatccaaat gacttcttgg ttggccaacg tcataacttg ccacaagtca acgtcatgaa
     6781 cgacgacgga actatgaatg agcttgcctt tgaattttca ggcatggatc gttttgaagc
     6841 tcgtaaggca gtcgttgcta agttggaaga aatcggtgcc cttgtcaaaa tcgaaaaacg
     6901 tgtccattca gtcggtcact cagaacggac aggtgtcgta gttgagccac gcttgtctac
     6961 tcaatggttc gtcaagatgg accaattggc taagaacgcc attgccaacc aagacacaga
     7021 ggacaaggtc gaattctacc cacctcgttt caacgatacc ttccttcaat ggatggaaaa
     7081 tgtccacgac tgggttatct ctcgtcagct ttggtggggt caccaaatcc ctgcctggta
     7141 caatgctgat ggtgaaatgt atgtcggcga agaagctcca gaaggtgacg gatggactca
     7201 ggacgaagac gtcttggata cttggttcag ttctgccctc tggccatttt caaccatggg
     7261 ctggcctgaa gtcgactcag aagactttaa acgttatttc ccaacttcaa ccttggtaac
     7321 aggttacgac atcatcttct tctgggtgtc tcgtatgatc ttccagtcat tggaattcac
     7381 aggccgtcaa ccattccaaa acgtccttat ccacggtctc attcgtgacg agcaaggacg
     7441 caagatgtct aagtctctcg gtaacgggat tgacccaatg gatgttatcg agaaatacgg
     7501 tgccgatgcc cttcgatggt tcctttcaaa cggttctgcg ccaggacaag acgtgcgttt
     7561 ctcttatgag aaaatggatg cttcatggaa ctttattaac aagatttgga acatttctcg
     7621 ctatatcctc atgaacaatg gaggtttgac gctggatgtg gcgcatgaca atgtcacaaa
     7681 agttgcaaca ggtgaggctg gtaatgtgac ggaccgctgg attctccaca atctcaacga
     7741 aaccattgca aaagttactg aaaactttga taagttcgag tttggtgtgg ctggtcatat
     7801 cctttacaac ttcatttggg aagaatttgc caactggtat gttgagttga ccaaggaagt
     7861 cctttatagc gataacgaag aagagaaagt catcacacgt tctgttctac tatacacttt
     7921 ggacaagatc cttcgtctcc ttcacccaat catgccattc gtgacagagg aaatctttgg
     7981 acaaatctca gaaggttcta tcgtgacagc tgcataccca actgttaatc tagcctttga
     8041 agaccttgcg gctcacactg gtgtggaaag tctcaaagac ttgattcgtg ctgttcggaa
     8101 tgcgcgtgcg gaagtaaatg tagcaccaag caagcctatc accatccttg ttaagacaag
     8161 cgatagcgac ttggaagcct tctttaacag caatgtcaac tatatcaaac gctttacaaa
     8221 tccagaacac ttggaaatcg catcaaccat ccctgcacct gaactggcta tgtcaagcgt
     8281 tattacagga gccgaaatct tcttgccact ggccgatctc ctcaatgttg aagaagaact
     8341 agctcgtctc gacaaagaac tcgctaaatg gcaaaaagaa ctggacatgg ttggtaagaa
     8401 actctctaac gaacgcttcg tcgccaacgc taaaccagaa gttgtccaaa aagaaaaaga
     8461 caaacaagcc gactaccaag ccaagtatga tgtgaccgta gcacgtattg atgagatgaa
     8521 gaagttggtg aaataaacac agaaacacgg tgatgagccg tgttttttgg tataatgaaa
     8581 tcaatatcta ttgatggaga aagtgatgtc caaacaccct cattatgaat tgttaaattt
     8641 aattggctac ggtcttgcca agtttgacaa gctttttata aaagaatttc aatgctctag
     8701 caagtcggag ttttatcgct atgtggtttc tctgggaatt gctgaaacaa ctggagttgt
     8761 aaaaaataga atggatttat ttgatcctta ttttgacaat aatcgaaaag gttggtggca
     8821 gaaagctgaa gtttatcgtt ttcgtaaaga tttaattgat atgatgtttg gaaatgaaga
     8881 tgttcatagt tatgctgaat agttaaaatg ttacttgcca gtgaagggaa gaaaacaggc
     8941 ataaccatcg ttgaaaaacc aatagttcga actaaattca aacgtctaca ggaaacggga
     9001 atggaggctg agaattattt tatccttcat tttgataaag aagaaaaatt ccaaggtgga
     9061 cagttaaccg atgcccgtct ttatggtgat ggatatgact ttcaggtaga tgtccaagag
     9121 tattcttacc ttgccgaagt aaaaggtatc cgaaaatcta aggggcgtgt gcgtttaact
     9181 gcaaaagaat ttgaaaaagt caaggagttt caatcggatt ttattttatc cttggtcaca
     9241 aatctagatg atattccaaa gttagtgtta atcgataatc ctttaaaaca ttttgagttt
     9301 aaaaagaata ttatcaaaaa tgaaatcatt gaatatagaa gcgtagagga tttgtattag
     9361 ttccccctta acttttccag ttgaaggaac gagaagtctt gataggtcaa cgacttaatg
     9421 aactggaaat caacggtatt cgtttgacta agttttaaga tggcgaaatc ggtattgaat
     9481 ttatcagtag tgctgattat aactctttta ttatttacat gaagtatata tatatatata
     9541 tcatagaacc tattgtgagg actttttata gtttaagcca gtttccaacc aatttcgtga
     9601 tttactggta atgaagaaaa acaattgaaa ggatatttct atgcaaccaa cttacaacat
     9661 tgacaatcca aacttgtctt atgaagctaa gcgtgattta tggcggatag gttttggtct
     9721 gcagaaagtt gacaatctag tgccatcagc ttatatggaa tctttggctg agaaacaggc
     9781 tcggggtgaa ctgacttatg agcaggttta tgaggatgca acggcttatc accatactat
     9841 tgatgcaagt acggaggagg cagacttggt ttctctacgc attgtagaac tattgtctcg
     9901 aagaggcttt agcttcagtc ctgcgacctt acttgctatt cataaggagt tgtttcaaga
     9961 tatatttgaa ccctcgattc cggtaggtca atttcgtcag actaatatca caaagaatga
    10021 acctgttttg aatggtgaaa gtgttgtgta ctctgattac tccatgattc aaatgacatt
    10081 ggattatgat tttaatcagg aaaaacaagt tgcatatgcg acactaaccc aggcggatat
    10141 ggttaaaaaa atccagcatt ttatttcagg aatctggcag attcatccat ttcgcgaagg
    10201 aaacgctcgg acagtaacgg tctttttgat tcagtatctt cgtgagtttg gttttgatat
    10261 tgataatata ccatttcagc aacattccaa gtattttcgt gatgccttgg tattagataa
    10321 tgcaaagatt ttacagcgac gtcctgagtt tttaacagct ttttttgaaa atctcttgct
    10381 cggtggtcaa aatgatttgt cttcagaaaa aatgtatcta gatttagacc tcgatttttc
    10441 ataatccaaa tactgagtaa acattgaatt ttaggaaaaa atgaagtaaa c
//
LOCUS       DBERMM010000056        10335 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.058, whole genome shotgun sequence.
ACCESSION   DBERMM010000056 DBERMM010000000
VERSION     DBERMM010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10335)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10335)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10335
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.058"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..354
                     /locus_tag="ACL8AS_001883"
     CDS             <1..354
                     /locus_tag="ACL8AS_001883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HGS1229690.1"
                     /translation="YQRISLVAGLTNGELIVPMTYEETMTSDFFEAWFQKFLLPTLTT
                     PSVIIMDNARFHRMGKLELLCEEFGHKLLPLPPYSPEYNPIEKTWAHIKKHLKKVLPS
                     CNTFYEALLSCSCFN"
     gene            254..700
                     /locus_tag="ACL8AS_001884"
     CDS             254..700
                     /locus_tag="ACL8AS_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HGS1229691.1"
                     /translation="MRKHGLISKSTSKRYYQVAIPFTRLFCPALVSIDYINCLSETTD
                     KNWHKSDRIFVTNIGKPVHSSILSKSLQRANERLKKPIPKHLPPHIFRHTTISILSEN
                     KIPLKTITDRVGHSDSEVTTSIYTQVTKNMKDEAINVLDKVMKKIF"
     gene            complement(838..2142)
                     /gene="eno"
                     /locus_tag="ACL8AS_001885"
     CDS             complement(838..2142)
                     /gene="eno"
                     /locus_tag="ACL8AS_001885"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="surface-displayed alpha-enolase"
                     /protein_id="HGS1229692.1"
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTG
                     EHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
                     KGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPI
                     AFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDG
                     VETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQID
                     YLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQE
                     GAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQ
                     IKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK"
     gene            2306..2752
                     /locus_tag="ACL8AS_001886"
     CDS             2306..2752
                     /locus_tag="ACL8AS_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YueI family protein"
                     /protein_id="HGS1229693.1"
                     /translation="MTDLSKQLLEKAHGGLKINPDEQRRYLGTFEERVLGYVDIDTAN
                     SPQLEKGFLFILENLQEKAEPLFVKISPTIEFDKQVFYLKEAKETDSQATIVSEEHIT
                     SPFGLVIHSNAPVQVEEKDLRLAFPKLWEVKKEEPAKTSLWKKWFS"
     gene            complement(2769..3779)
                     /locus_tag="ACL8AS_001887"
                     /pseudo
     CDS             complement(2769..3779)
                     /locus_tag="ACL8AS_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706318.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008887 - glycerate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0031388 - organic acid phosphorylation
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
     gene            complement(3788..4117)
                     /locus_tag="ACL8AS_001888"
     CDS             complement(3788..4117)
                     /locus_tag="ACL8AS_001888"
                     /inference="COORDINATES: protein motif:HMM:NF019887.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="HGS1229694.1"
                     /translation="MERLAKSLGIAYFTANQLEVKEGLLTGKLVGQIISPQVKKETLE
                     KWRKKLKLSKERTVAIGDGVNNLLMLKSAELGIAFCAKEVLKKEIPHHVDKRDFLEVL
                     PLIDCLE"
     gene            complement(4062..4433)
                     /locus_tag="ACL8AS_001889"
     CDS             complement(4062..4433)
                     /locus_tag="ACL8AS_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family phosphatase"
                     /protein_id="HGS1229695.1"
                     /translation="MSQVKGLCVLDVDGTLILEEVIDLLGREAGHEAEISQITSRAMR
                     GELVFESSLRKRVSLLEGLPILVFDNVFNSIHLSLNVPEFISILQKNGILVGLVSGGF
                     TPIVGEISKIPWYCLFHCQPA"
     gene            complement(4492..5925)
                     /gene="glgA"
                     /locus_tag="ACL8AS_001890"
     CDS             complement(4492..5925)
                     /gene="glgA"
                     /locus_tag="ACL8AS_001890"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004373 - glycogen (starch) synthase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HGS1229696.1"
                     /translation="MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYY
                     DMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDF
                     DDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYRWIQAYEDIETVL
                     TIHNLEFQGQFSEGMLGDLFGVGLERYADGTLRWNNCLNWMKAGILYANRVSTVSPSY
                     AHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAK
                     NKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPA
                     FEGAFSWFAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGT
                     LPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNL
                     QKQAMESDFSWDTACKSYLDLYHSLVN"
     gene            complement(5922..7061)
                     /gene="glgD"
                     /locus_tag="ACL8AS_001891"
     CDS             complement(5922..7061)
                     /gene="glgD"
                     /locus_tag="ACL8AS_001891"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008878 - glucose-1-phosphate
                     adenylyltransferase activity [Evidence IEA];
                     GO_process: GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HGS1229697.1"
                     /translation="MKIDKYSAILGNTVGFHNMSTLTDHRPVASLPFGGKYRLIDFPL
                     SSLANAGVRSVFGIFQQDNISSVFDHIRSGREWGLSTLLSHYYLGIYNTRVESSTVGK
                     EYYQQLLTYLKRSGSNQTVALNCDVLINIDLNQVFHLHSTTKEPITVVYKKLAKKDIS
                     EVNAILDVDETDHVLSHKLFDSKSTAEMFNMSTDIFVVDTPWLIEHLEEEAKKEHPKK
                     LRYVLRDLAVKEGAFAYEYTGYLANIHSVKSYYQANIDMLESQKFYSLFSPNQKIYTK
                     VKNEEPTYYANTSKVSTSQFASGSIIEGQVANSVLSRNIHVHKDSLVKDSLLFPRVVI
                     GKGAQVEYAILDKGVEVEPGVVIRGTAEHPVVVKKGAKVTEDIHS"
     gene            complement(7051..8193)
                     /locus_tag="ACL8AS_001892"
     CDS             complement(7051..8193)
                     /locus_tag="ACL8AS_001892"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000787267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008878 - glucose-1-phosphate
                     adenylyltransferase activity [Evidence IEA];
                     GO_process: GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HGS1229698.1"
                     /translation="MKNKMLALILAGGQGTRLGKLTQSIAKPAVQFGGRYRIIDFALS
                     NCANSGIHNVGVVTQYQPLALNNHIGNGSSWGLDGINSGVSILQPYSASEGNRWFEGT
                     SHAIYQNIDYIDSVNPEYVLILSGDHIYKMDYDDMLQSHKDNNASLTVAVLDVPLKEA
                     SRFGIMNTDANNRIVEFEEKPAQPKSTKASMGIYIFDWQRLRNMLVAAEKSKVGMSDF
                     GKNVIPNYLESGESVYAYEFSGYWKDVGTIESLWEANMEYISPENALDSRNRQWKIYS
                     RNLISPPNFLGANAHVEDSLVVDGCFVDGAVKHSILSTGAQVREGAEVLDSVIMSGAI
                     IGQGAKIKRAIIGEGAIISDGVEIDGTDEVQVVGYNEVVGVATDED"
     gene            complement(8183..10111)
                     /gene="glgB"
                     /locus_tag="ACL8AS_001893"
     CDS             complement(8183..10111)
                     /gene="glgB"
                     /locus_tag="ACL8AS_001893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003844 - 1,4-alpha-glucan branching
                     enzyme activity [Evidence IEA];
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_function: GO:0043169 - cation binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="1,4-alpha-glucan branching protein GlgB"
                     /protein_id="HGS1229699.1"
                     /translation="MDNREALKTFMTGENFYLQHYLGAHREELNGEHGYTFRVWAPNA
                     QAVHLVGDFTNWIENQIPMVRNDFGVWEVFTNMAQEGHIYKYHVTRQNGHQLMKIDPF
                     AVRYEARPGTGAIVTELPDKKWRDGLWLARRKRWGFVERPVNIYEVHAGSWKRNPDGS
                     PYSFAQLKDELIPYLVEMNYTHIEFMPLMSHPLGLSWGYQLMGYFALEHAYGRPEEFQ
                     DFVEECHTHNIGVIVDWVPGHFTINDDALAYYDGTPTFEYQDHNKAHNHGWGALNFDL
                     GKNEVQSFLISCIKHWIDVYHLDGIRVDAVSNMLYLDYDNAPWTPNKDGGNLNYEGYY
                     FLQRLNEVIKLEYPDVMMIAEESSSATKITGMKEIGGLGFDYKWNMGWMNDILRFYEE
                     DPIYRKYDFNLVTFSFMYVFKENYLLPFSHDEVVHGKKSMMHKMWGDRYNQFAGLRNL
                     YTYQICHPGKKLLFMGSEYGQFLEWKSEEQLEWSNLEDPMNAKMKYFTSQLNQFYKDH
                     RCLWEIDTSYDGIEIIDADNRDQSVLSFIRKGKKGEMLVCIFNMVPVERKDFTIGLPV
                     AGIYEEVWNTELEEWGGVWKEHNQTVQTQEGLWKDYEQTLTFTLPAMGASVWKIKRRL
                     KSTKTVTNKNQKGVENEK"
BASE COUNT         3135 a         2275 c         1833 g         3092 t
ORIGIN      
        1 tatcagagga tttctttggt tgcaggtcta acaaatggtg agttaatcgt tccaatgact
       61 tacgaagaga cgatgacgag cgactttttt gaagcttggt ttcagaagtt tctcttacca
      121 acattaacca caccatcggt tattattatg gataatgcaa gattccatag aatgggtaag
      181 ttagaacttt tatgcgagga gtttggtcat aaacttttac ctcttcctcc ctactcgcct
      241 gagtacaatc ctattgagaa aacatgggct catatcaaaa agcacctcaa aaaggtatta
      301 ccaagttgca atacctttta cgaggctctt ttgtcctgct cttgtttcaa ttgactatat
      361 aaattgtcta agcgaaacaa ccgataagaa ttggcacaaa agcgaccgta tttttgttac
      421 caatatagga aaaccagttc atagttctat cttgagcaag tctctccagc gagcaaacga
      481 acgccttaaa aaaccaattc ccaaacatct gccccctcac atcttcagac acaccactat
      541 tagcatctta tcagaaaata aaattccttt aaaaacaatc acggacaggg ttggtcattc
      601 cgactctgaa gtcactactt ccatctacac ccaggtcaca aagaatatga aagatgaagc
      661 aatcaatgta ctggataaag ttatgaaaaa gattttttaa aaagttttgt cccttttttg
      721 tcctctaaat acaaaaatag cccttcggat aaaatccgag gggctagaaa cgttgttaaa
      781 tcaacggccg aacttttgaa tttcatggtt cgggataaaa tagttcactg aactatttta
      841 ttttttaagg ttgtagaatg atttcaatcc acgatattca gctacttcac caagttggtc
      901 ttcgatacga agcaattggt tgtatttagc gatgcggtct gtacgtgaaa gtgaaccagt
      961 cttgatttgt cctgcgttag ttgcaactgc aatatcagcg attgttgaat cttcagtttc
     1021 acctgaacgg tgtgatacaa cagcagtgta accagcttct ttagccattt cgatagcttc
     1081 aaaagtttca gtaagagtac cgatttggtt aactttgata aggattgagt tagcagcacc
     1141 ttcttggata ccacgtgcaa ggtagtcagt gtttgttacg aagaagtcgt caccaacaag
     1201 ttgtactttc ttaccaagac gttcagtaag agctttccaa ccatcccagt cgttttcatc
     1261 cataccatct tcaatagtga tgattgggta tttgttaacc aattcttcaa ggtagtcgat
     1321 ttgttctgca gatgtacgaa cagcagcacc ttcaccttca aatttagtgt agtcgtaaac
     1381 tttacgttct ttatcgtaga attctgatga agcacagtca aatccgataa atacgtcttt
     1441 acctggtaca tatccagcag cttcaatcgc agcaaggata gtttcaacac catcttcagt
     1501 tccttcgaaa cgaggagcga atccaccttc gtcacctacg gcagtttcca aaccacgtga
     1561 tttaaggatt ttcttaagag cgtggaagat ttcagcaccg taacgaaggg cttctttaaa
     1621 tgttggcgca ccaactggca agatcatgaa ctcttggaaa gcgattggag cgtcagagtg
     1681 agaaccaccg ttgatgatgt tcatcattgg agttggaaga actttagtgt tgaatccacc
     1741 aagatagctg taaagtggga tttcaaggta gtcagcagca gcacgagcta cagcgataga
     1801 cacaccgagg attgcattcg cacccaattt acctttgtta ggagtaccgt caagtgcgat
     1861 catagcacgg tcaatagctt gttgatcacg tacatcgtag ccaatgatag cttcagcaat
     1921 gatgttgttt acgttgtcaa cagctttttg tgtaccaaga ccaccgtaac gagatttgtc
     1981 accgtcgcga agttcaactg cttcgtgttc accagtagaa gctcctgatg gaaccatacc
     2041 acgtccgaaa gcacctgatt cagtgtaaac ttctacttca agtgttgggt taccgcgtga
     2101 gtctaggact tcgcgagcgt aaacatcagt aataattgac attttttact ctccttatga
     2161 gttaaatttt ttacacctct ataatacctt aaaacccctc ctttttcaag aaaaaacgtt
     2221 atctttgtgc aacttttcct taactttata aagtaatcgc tttcttttgt ctgttttatt
     2281 ctaactttta tgatatactg ttttcatgac agatttatca aaacaattac ttgaaaaagc
     2341 tcatggtggg ttaaaaataa atccggatga gcaaagacgc tatcttggta cttttgagga
     2401 aagagttctt ggatatgtag atattgacac agcaaatagc cctcagttag aaaaaggctt
     2461 tttatttatt ttagaaaacc ttcaggaaaa agcagagcca ctatttgtga agatttcacc
     2521 aactatcgaa tttgataagc aagttttcta cttaaaagaa gcaaaagaaa ctgatagtca
     2581 agccaccata gtatctgaag agcatattac ttctcctttt ggcctggtta ttcatagcaa
     2641 tgcaccagtt caagtagaag aaaaagacct tcgacttgct tttccaaaac tttgggaagt
     2701 taaaaaggaa gaaccagcca aaacatcctt atggaagaaa tggtttagct aaatcttgca
     2761 catatttaaa tagaaaagac agcttggata ttttcaaatg gtaggggagg taaatcttca
     2821 gcaagactac cgcaaatagc aataacagga actccaacag gggttctttt tgcaacacct
     2881 ataggcgctt tcccagcaaa gctttgactg tcaagtcttc cttctccaac aacaaccaag
     2941 tcagcatctg aaactttctt atcaaagttg attaagtcca agcaggtatc aattccagac
     3001 acgatacttg cctgagcaaa ggcacacaaa ccaccagcaa ggcctccacc tgctcctgct
     3061 cctttaattt ctaatgttgc aggtgagaat ttttcataaa aatcttggat cgcctgatct
     3121 acgactgcaa acatagtcgg atgtagacct ttttgattgc caaaagtgta agtcgcacct
     3181 tgataaccac ataagggact cacgacatct gctaaaatat gaatttgaac accttcagga
     3241 attttatagc gattttctgt tgaaacagaa gctaagttta ataaggattg accggaagca
     3301 ggcaagacat ttccatccct atcataaaat tgataaccta aaccagcagc aatccccagt
     3361 cctccatcat tactggccgt gccaccaaca ccgatataaa tatctttaat ccctttagaa
     3421 atgagatgga gaatcaactc tccaatacca caagtttgga tttgaagtgg atttcgtttc
     3481 tctagcggaa tttttccaag accaaccaag tcagctactt caaatagtgc cagttcccct
     3541 ttttgaaaat agcgcatggc ttctttttgt ccaaaagggt ctgtcacttg gatccatttt
     3601 tcttttaggt caagagaatg tcggatagca tctacagtac cttctccccc atcaccaaca
     3661 gggcagagga gacattctac atctgctatc gattgttgga agcctctttt tattgcttca
     3721 gctacctgtt gagctgtcaa gctttcctta aacgaatccg gtgcaattac aatcttcata
     3781 ttttccctca ttctaaacag tcaatcaaag gaagaacttc taaaaaatcc ctcttgtcaa
     3841 catgatgtgg tatttctttt ttgagcactt ctttggcaca aaaggcgatt cctaactccg
     3901 ccgacttcaa cattaataga ttattgaccc catcaccgat tgccaccgtt ctttctttag
     3961 aaagttttag tttctttctc catttttcca gagtttcttt tttgacctgg ggacttataa
     4021 tttgtccaac taattttcct gttaaaagac cttctttgac ttcaagctgg ttggcagtga
     4081 aataggcaat accaagggat tttgctaatc tctccaacta ttggtgtaaa tccaccagac
     4141 accagaccaa ctaggatgcc attcttttgg agaatagaga tgaactctgg gacatttagc
     4201 gatagatgaa ttgagttgaa gacgttatca aagaccaaaa taggaagacc ttccaacaag
     4261 gacactcttt ttcttaaact gctttcaaag accaactctc ctcgcattgc tcgacttgta
     4321 atctgcgaaa tttccgcctc atgacctgcc tctctcccta aaagatcaat cacttcttct
     4381 aggattaagg ttccatctac atccaaaaca cacaagcctt ttacttgaga catcagttct
     4441 cctctctaaa cagcctaaaa atcgtatgaa gtcatcatac gattttatct attaattaac
     4501 taaactatgg tacaagtcaa ggtatgactt gcaggctgta tcccatgaga agtcactctc
     4561 catagcttgt ttttgtaggt ttctccaaat gtctggatgg tttctataca agtccaatgc
     4621 tgtttggaaa gtccaattta accaataagg agatagattg tcaaagctaa agccagtacc
     4681 gcttccttcg attggattga aagcgcgaac tgtatctcgc aagcctccaa cttcatggac
     4741 caatggcaag gttccataac gcatagccat catttgagac aagccacacg gttcaaaacg
     4801 acttggcatg aggaagaggt cacaagcagc gtagatttcc tgagcaagtt tgacatcaaa
     4861 agtgatattt gttgatagct tgtctgggta aatctgagca aaccatgaga aagctccttc
     4921 aaaggctgga tcgccagttc ccaaaagaac aatctgaaca tcttcttgca agatatggtg
     4981 aagactttcg accaccacat caaaaccttt ttgacgtgtc aaacgagaaa caattcccac
     5041 cagtggaacg tctgctctaa caggcaagcc aactctttct tgcaattttg ccttattttt
     5101 ggctttccca gacaaatctt cctgattgaa atgatagtct aaaagagcat ccgtctgagg
     5161 attataaaga tcagcatcaa tcccattcac gataccagat actttaccag actccatttt
     5221 aagaatctga tccaaattac atccaaactg actagtcata atttcatgag catagctagg
     5281 tgaaacggtt gaaacacggt tcgcatagag aatacctgcc ttcatccagt tcagacagtt
     5341 gttccatcga agggtgccat cagcgtaacg ttcaaggcca actccaaaca aatcacccaa
     5401 cattccttct gaaaattgtc cttggaattc taaattatga atggttaaaa ctgtttcaat
     5461 gtcctcatag gcttgaatcc aacggtattt ttccttcaac aagaaaggaa tcatagctgt
     5521 atggtagtca tgaacatgga gaagatcagg aataaagtca atcctttcca tagcctcaat
     5581 ggcagccagt tggaaaaagg caaagcgttc tccgtcatca aaatcaccgt aaacatgacc
     5641 acggaagaaa taatattgat tgtcaataaa gtagaaggtt acaccattta atactgtttt
     5701 cttaattcca caatactgtc tgcgccaacc aacgctcacc tcaaaatgaa gcacatcttc
     5761 aatctgattt ccaaatttag cctctaccat atcatagtag ggtaaaatca ctgcaacttc
     5821 gtgcccagct tttaccagtg attttggaag agcgccaatg acgtctccca aaccacctgt
     5881 ttttgaaaaa ggtgcaccct ctgctgctac aaataaaatt ttcatgaatg aatatcctct
     5941 gttactttag cacctttctt aaccacaact ggatgttctg cagttcctcg aatcacaaca
     6001 ccaggctcaa cttcaacccc tttgtccaag atagcatatt cgacctgagc cccttttcca
     6061 ataacaacac gagggaagag caggctatct ttaaccaagc tatccttatg gacatgaata
     6121 ttacgtgata gaacagaatt agctacttga ccttcaataa tactaccaga ggcaaactga
     6181 gaagtgctta ccttagatgt attagcatag taagttggct cttcgttttt gacctttgta
     6241 taaatctttt ggtttggtga gaaaagagaa tagaattttt gtgattcaag catatcgata
     6301 ttcgcttgat aataagattt aacagagtga atattggcta gatagcccgt gtactcgtag
     6361 gcgaaagctc cctcttttac agccaaatcc cgtaaaacat agcgcaattt ctttggatgt
     6421 tcttttttag cttcttcttc caagtgttca atcaaccaag gtgtatcaac gacaaagata
     6481 tctgtagaca tattgaacat ttcagctgtt gacttgctat caaagagttt atgagaaaga
     6541 acatggtctg tttcatctac atccaagatt gcatttactt ctgaaatatc tttcttagct
     6601 agttttttat aaactacagt gataggctct tttgttgtac tatgtaggtg gaaaacttgg
     6661 ttcaaatcaa tgttaataag aacatcgcag ttgagggcaa ccgtttggtt tgagccagaa
     6721 cgtttcaaat aagtaagaag ctgttggtag tattcttttc caactgtact actttctaca
     6781 cgggtattgt aaattcctag atagtaatga ctaagaaggg ttgataagcc ccactcgcgt
     6841 cctgaacgaa tatggtcaaa tactgagctg atattatcct gctggaaaat accaaagaca
     6901 ctacgaacac ctgcattagc aaggcttgaa agtgggaagt caatcaaacg atatttccca
     6961 ccaaatggca aacttgctac tggacggtgg tccgtcaatg tcgacatatt gtgaaaacca
     7021 actgtatttc ctaaaatggc agaatattta tcaatcttca tctgttgcta cccccactac
     7081 ttcattatat cctacaactt gtacttcatc tgttccatca atttcgacac cgtcagaaat
     7141 aatcgcacct tcaccaataa tggcacgttt aatcttagct ccttgaccaa tgatagctcc
     7201 actcatgata actgaatcaa ggacttccgc tccttcgcga acttgcgcgc ctgttgaaag
     7261 gatagaatgt ttaacagctc catcaacgaa acatccgtct acaactaatg agtcttccac
     7321 atgagcattt gccccgagga agtttggtgg tgaaatcaag tttcttgagt aaatcttcca
     7381 ttgacggtta cgactatcca aggcattttc tggagaaata tactccatgt tcgcttccca
     7441 aagtgactca atagtaccaa catctttcca ataaccacta aattcgtaag cataaacact
     7501 ttcacctgac tcaaggtaat ttggaatgac atttttacca aagtctgaca tgccaacctt
     7561 gctcttttca gcagcgacta acatattacg aaggcgttgc caatcaaaaa tgtagattcc
     7621 catagaagct tttgtagatt taggttgagc tggtttttct tcaaattcaa caatacgatt
     7681 gttagcatct gtgttcatga taccaaaacg gcttgcttct ttaagaggga cgtccaaaac
     7741 tgctactgtc aagctggcat tattatcctt atgagactgg agcatatcat catagtccat
     7801 tttgtagatg tggtccccag acaaaatcaa gacatactca ggattgacac tgtcgatata
     7861 gtcgatattt tggtaaatag cgtgactagt tccctcaaac caacgatttc cttcacttgc
     7921 agaataaggt tgaagaatag agacgcctga attaataccg tctagtcccc agcttgaacc
     7981 attcccaata tggttgttga gagcaagtgg ttgatactgt gtaacgaccc caacattatg
     8041 aatccctgag ttggcacagt ttgatagggc aaagtcaatg atacggtagc gcccaccaaa
     8101 ttgcacagct ggttttgcga tgctttgagt gagtttaccg agacgagttc cttgcccacc
     8161 agcaagaatc aaagctaaca ttttattttt cattttctac tcctttttgg tttttatttg
     8221 tgacggtttt agtagatttc aagcgacgtt tgattttcca tacacttgct cccatagccg
     8281 gtagagtaaa ggttaaggtc tgctcataat ctttccatag gccttcttgc gtttgaacag
     8341 tttgattatg ttctttccaa acgcctcccc actcttccaa ctcagtattc catacttctt
     8401 cgtaaattcc tgcaacgggt agtccgattg taaaatcttt ccgctcaaca ggtaccatgt
     8461 taaagataca gactaacatt tctccctttt tacccttacg aataaaggaa agaacactct
     8521 ggtctcgatt atccgcatca atgatttcaa taccatcata gctggtatcg atttcccaca
     8581 gacagcgatg atctttgtaa aactggttta gctgagaagt gaaatacttc atcttagcat
     8641 tcattgggtc ttctaggtta gaccattcca actgttcttc agatttccat tctaggaatt
     8701 gaccgtattc gctacccatg aagagcaatt tcttaccagg gtgacaaatt tggtacgtat
     8761 agagattgcg caagcctgcg aattgattgt aacgatctcc ccacatctta tgcatcatac
     8821 tcttcttgcc atgaaccact tcatcgtgcg agaatggcaa gagataattc tccttgaaaa
     8881 catacataaa gctgaaagtc accaggttaa agtcatattt acgataaatc ggatcttctt
     8941 cgtagaaacg gaggatatca ttcatccagc ccatgttcca tttgtagtca aatcctagac
     9001 caccaatctc tttcattccc gtaatcttgg tcgcagacga actttcttct gcaatcatca
     9061 tcacatctgg atattctaac ttaataactt cattcaagcg ttgaagaaaa taataacctt
     9121 catagttaag atttccgcca tctttattag gtgtccatgg agcattatca tagtccaaat
     9181 agagcatgtt gctaacagca tccacacgaa taccatccaa atgatagaca tcaatccaat
     9241 gcttaatgca agaaattaag aaggactgga cttcattttt tccaaggtca aaattaaggg
     9301 caccccaacc atggttatga gccttattat ggtcttggta ttcaaaagtc ggtgtcccat
     9361 cataataggc taaggcatca tcgttgatgg taaagtgacc tggtacccag tccacaataa
     9421 ccccaatatt atgggtatga cactcctcga caaaatcttg aaactcctct ggtctgccat
     9481 aagcatgctc taaagcgaag taacccataa gctgataccc ccaactcaag cccaaaggat
     9541 gggacatcaa gggcataaac tcaatatgag tatagttcat ttcaacgaga taaggaatga
     9601 gttcatcctt gagctgggca aaactataag gactgccatc aggatttctc ttccaagagc
     9661 cagcatgaac ctcgtaaata ttgacaggac gttcaacaaa gccccaacgt tttcttcgtg
     9721 ccagccaaag tccatccctc catttcttat caggaagctc tgttacgatt gcccctgttc
     9781 ctggacgagc ctcatacctg acagcaaaag ggtcaatctt catcagttga tgaccatttt
     9841 gacgtgtgac atgatatttg taaatatgcc cttcttgagc catattggta aagacttccc
     9901 agaccccaaa gtcatttctt accattggaa tctgattttc aatccagttg gtaaaatcac
     9961 caaccaagtg aacagcctga gcattaggtg cccaaacacg gaaggtatag ccatgctctc
    10021 catttagttc ttccctatgt gctcctagat aatgttggag ataaaaattt tcacccgtca
    10081 taaaggtttt taatgcttct ctattatcca tatactcccc ttctcctgta agcgttttct
    10141 atgtttttat tatactacct ttttagagaa gattcaagta aattactata cttctttaat
    10201 tattttgaaa atctacaaca agttcactta ctcgttcaat tgtaaatcaa tattttttca
    10261 aaaaattgcg aaaacgcctt tctttttcta ctatagtgaa atgaaataaa acatgcgcaa
    10321 atcgatcagg acagt
//
LOCUS       DBERMM010000057         9943 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.059, whole genome shotgun sequence.
ACCESSION   DBERMM010000057 DBERMM010000000
VERSION     DBERMM010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 9943)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9943)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9943
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.059"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(50..1753)
                     /gene="ilvD"
                     /locus_tag="ACL8AS_001894"
     CDS             complement(50..1753)
                     /gene="ilvD"
                     /locus_tag="ACL8AS_001894"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004160 - dihydroxy-acid dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HGS1229700.1"
                     /translation="MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVIS
                     TWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDI
                     IADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
                     IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLP
                     GSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNA
                     TLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLL
                     ANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDG
                     AVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEML
                     SLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQ
                     DTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGK
                     K"
     gene            complement(1986..2918)
                     /locus_tag="ACL8AS_001895"
     CDS             complement(1986..2918)
                     /locus_tag="ACL8AS_001895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HGS1229701.1"
                     /translation="MMRSTKELRHVYRDFLLEANQSYSDIVVLEADLSSSMATHNLEK
                     DFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFGPFASRRVFDQLFISLGYAQLDA
                     TVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
                     YIRTIRKAPEAVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSV
                     GVIDLFRIKPIPEQIKTMLSGKTIFTVENHNQIGGIGSALCELFSDDGITKIHRMGVQ
                     ERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR"
     gene            complement(2915..3772)
                     /locus_tag="ACL8AS_001896"
     CDS             complement(2915..3772)
                     /locus_tag="ACL8AS_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HGS1229702.1"
                     /translation="MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVL
                     AVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNTNGTK
                     LPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
                     EAIQFASHQQLSNLIVFVDENKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIR
                     EIYEGIVQLKQSNNSSPKCIVLDTIKGQGVQELEEMKSNHHLRPTVEEKQMLTSVVER
                     LSQELEETE"
     gene            complement(3776..5122)
                     /locus_tag="ACL8AS_001897"
     CDS             complement(3776..5122)
                     /locus_tag="ACL8AS_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000975284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HGS1229703.1"
                     /translation="MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVG
                     FLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATAMIMFAGM
                     VFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSIS
                     PAFVQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRD
                     STVSITLSMAVIYIIVAIFAGSEYIEKEISSGTSGLVYALQLAGQFAAGVFVILAGVR
                     LILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFVGGLVSMAIMIA
                     SGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGL
                     GFQGSTFSDADFGLSGIILGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSAKEE"
     gene            complement(5135..5419)
                     /locus_tag="ACL8AS_001898"
     CDS             complement(5135..5419)
                     /locus_tag="ACL8AS_001898"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008089859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HGS1229704.1"
                     /translation="MLKIGTACGSGLGSSFMVQMNIESVLSDLNVSDVEVEHYDLGGA
                     DPNAADIWIVGRDLADSASHLGDVRILNSIIDMDELRELITKLCEEKGLI"
     gene            complement(5423..7453)
                     /locus_tag="ACL8AS_001899"
     CDS             complement(5423..7453)
                     /locus_tag="ACL8AS_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000460919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HGS1229705.1"
                     /translation="MFDYRALVILMTLMDHCELSLYELSVKVSLPIKEVKEGIDYLVP
                     YLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFIS
                     NNHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMV
                     SELLESSIGIWGLDYVLSSWGYSLTYDLIDQVVKDYYEKLQLVPIVNQLKVYLFGLVF
                     ILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSS
                     CFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLP
                     SSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLP
                     QKCYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIK
                     VETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELE
                     LRLALKNYLYQKNDRKEIVPVLEQLITKETYQVSSQKLGWKEAIRLAAKPLLDQDKIT
                     ENYPEAMIQKVEEFGPFINLGKGVAIPHARPDEGVNEIGMSMLVLEEPIYLLDNPEQE
                     VRLLICIAAIDNESHLKALSHLTTILRDKNHVQTLISSKNYNDIKMIIKQED"
     gene            7645..8652
                     /locus_tag="ACL8AS_001900"
     CDS             7645..8652
                     /locus_tag="ACL8AS_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HGS1229706.1"
                     /translation="MTEKLINSKPNGVFALILIELTIVLGIFIFIMGVGSENIFGIII
                     GPLLIVIAGLAHAGLKVVKPQEALVLTLFGNYTGTIKEPGFYFVNPFSVAVNPANHTR
                     LGQSGDVSTKSPFLGAKSSNDNDVNLEIGKKHISLKVMTLSNSRQKINDCLGNPVEIG
                     IAVTWRVVDTAKAVFNVDNYKEYLSLQCDSALRNIVRIYPYDVSPNVDTTGDGQADEG
                     SLRGSSEIVANRIREEIQSRVEDAGLEILEARITYLAYAPEIAAVMLQRQQASAIIDA
                     RKMIVDGAVGMVEMALERLNEGELVELDEERKAAMVSNLLVVLCGNHDAQPIVNTGSL
                     Y"
     gene            8655..8855
                     /locus_tag="ACL8AS_001901"
     CDS             8655..8855
                     /locus_tag="ACL8AS_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HGS1229707.1"
                     /translation="MAEAKKKQIPLRLSTKLYAALASWAEDDFRSVNGQIEYLLTECV
                     KQRKKDGKYVSETIDEPFEIDI"
     gene            9007..9189
                     /gene="rpmF"
                     /locus_tag="ACL8AS_001902"
     CDS             9007..9189
                     /gene="rpmF"
                     /locus_tag="ACL8AS_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HGS1229708.1"
                     /translation="MAVPARRTSKAKKNKRRTHYKVTAPSVNFDETTGDYSRSHRVSL
                     KGYYKGRKITKAASAE"
     gene            9205..9354
                     /gene="rpmG"
                     /locus_tag="ACL8AS_001903"
     CDS             9205..9354
                     /gene="rpmG"
                     /locus_tag="ACL8AS_001903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001265622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HGS1229709.1"
                     /translation="MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVV
                     FTEVK"
     gene            complement(9834..>9943)
                     /locus_tag="ACL8AS_001904"
     CDS             complement(9834..>9943)
                     /locus_tag="ACL8AS_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HGS1229710.1"
                     /translation="TVSGKWYYTYNSGDLLVNTTTPDGYRVNANGEWVG"
BASE COUNT         3225 a         2101 c         1609 g         3008 t
ORIGIN      
        1 tacggcaagg cgacgttgac gtgatttgaa gagattttcg agtatgagtt tattttttac
       61 ctgacttgtc catattccag aagtctgtca cggctccgcg tgaagcagat gatacgatgt
      121 gggcatattt accgaggaca ccacggctgt aaagtggtgg caaggttgtt tctgccttgc
      181 gtttttcaag ttcttcttcg gatacagcca tggaaatttc tttggtatct tggtcaaccg
      241 taacgatatc gccggtacgg agataggcaa ttggtccacc atcctgagct tcaggagcga
      301 tatgtccaac aaccagacca taagtaccac cagagaaacg tccgtccgtc aagagggcca
      361 ccttatctcc ctgaccttta ccaacaatca ttgaagaaag tgatagcatc tcaggcatac
      421 caggaccacc tttaggtcca acaaaacgaa caacgactac atcgccatca acgatttcat
      481 ctgtcagaac ggcctgaatc gcatcttctt ctgagtcaaa gaccttagct ggtccaacgt
      541 gacgacgcac tttaacacct gataccttgg caactgcacc gtcaggagca aggttcccgt
      601 tcaagatgat aagcggacca tccgcacgtt ttggattttc aagtggcatg ataacttttt
      661 ggcctggagt caagtctgca aagtcagcca agttttcagc tacagtctta ccagtacatg
      721 tgatgcgatc tccgtgaagg aaaccatttg ccaacaagta cttcataacc gcagggacac
      781 caccgacttc gtagaggtct tggaagacat actgaccaga tggtttcaag tcggccaagt
      841 gaggcacacg ttcttgaatc gtattgaagt cctcaagtga caagtcaaca tttgcggcat
      901 gggcaatggc gagcaagtga agagtggcgt ttgtagaacc accgagagcc atcgttacag
      961 tgatagcatc ttcaaaggct tcacgagtca agatatctga tggtttgaga ccaagttcca
     1021 acatcttaac aacagcacgt cctgctgctt cgatatcttc tttcttatca gctgattcag
     1081 ctgggtgaga ggatgaccct ggcaaactca tccctagaac ttcgatagca gttgccatgg
     1141 tattagcagt atacatacca ccacagccac cagggccagg gcaggcatta cattcaagac
     1201 gtttcacgtc ctcagctgtc atgtcaccgt ggttccattt tccgatacct tcaaagacag
     1261 aaaccaagtc gatatcttta ccatcaagat ttcccggtgc aatagttcca ccataggcga
     1321 aaatagctgg gatatccata ttagcaatag caatcataga tccaggcatg ttcttgtcac
     1381 agccaccgat agcgacgaag gcatccacgt tgtgaccact catagccgcc tcgatggagt
     1441 ccgcgatgat gtcacgagat gttagagaga aacgcatacc aggcgttccc atagcgatcc
     1501 cgtccgctac ggtaatggtt ccaaactgta caggccaagc gcctgcagat ttgacacctt
     1561 ctttagccag tttcccgaaa tcatgcaagt gaatgttaca tggtgtattt tccgcccaag
     1621 tcgaaatcac tcccacaatc gatgtttcaa agtccttatc tgtcatacca gtcgcacgaa
     1681 gcatagcacg gttaggtgat ttaaccatgc tgtcatagat gctactgcgg tgacgtttat
     1741 ctaattcagt catcttatcc ctcccatttc agtttttact attatagcac aatttaaagg
     1801 caatgaacag aataaaattc ttgaattttc agaaaattct atacgcatgt gaaatattta
     1861 aaattaaaaa caacaaagcg gattagtgca ctttctgatg accagaatat gctttttaat
     1921 ccgctttctt taaataacgt actgtaattt ttacagaaat tctttcagat aagtgtattt
     1981 aacatctatc ttgcattata aatttctaga accttctctt ttatattcga ttcactcaaa
     2041 ccatactcat taagaagata atccattttc cctacttgac cgaatctttc ttgaacaccc
     2101 atccgatgaa tttttgttat tccatcatca gagaataatt cacataaagc actgccaatt
     2161 ccacctatct gattgtggtt ttctacagta aatatagttt ttccacttaa cattgttttt
     2221 atctgttctg gtatcggttt gattctaaat aaatctatca cacctactga ataacctaat
     2281 ttagacagtt catctgcaac tcgaatactt ggagcaacca ttatgccaga agcaacgatt
     2341 acaagatctt caccatgtct taactcaatg tagcccttag aaaaatcttc tccaccttga
     2401 tatacagcct ctggagcttt tctaattgtt cgaatatatt ttagtccttt taagtctaat
     2461 gtctgattca atatttcacg aaattggata tcatcagttg cttcaaaaat gattgattta
     2521 ggaattaaac gtaacaatcc aatttcttca aatggcatat gtgtcccacc attcatttct
     2581 gcagttactc ctgcatctga tccaatcaca gtggcatcca attgtgcgta tccaagagaa
     2641 ataaataatt gatcaaatac tcttcgtgaa gcaaaaggac caaatgtatg aagataaggt
     2701 ctaaacccct gaatagacaa gcctgctgca aggccgacca tttctgcttc cataatccca
     2761 acattcacat aacggtctcc gaagtccttt tcaagattat gagtagccat cgaacttgac
     2821 aaatcggctt ctaagactac tatatcagaa taactttgat tagcctctaa aaggaagtct
     2881 ctatatacat gccgtaattc tttcgtactt ctcatcattc tgtttcctcc aattcctgac
     2941 ttaatctttc tacaactgaa gttaacattt gtttctcctc tacagtaggg cgaagatgat
     3001 gattggattt catttcttcc agctcttgaa ccccttgacc tttaatagta tctaatacaa
     3061 tgcacttagg tgatgaatta tttgactgtt ttaattggac aatcccttca taaatttctc
     3121 taatatctga acccttgacc ctaatggatt caaatccaaa tgctgaaaat ttttctacga
     3181 aatcacctgg attacaaata tcctttgtaa aaccatctaa ttgttttttg ttctcatcaa
     3241 caaatacaat taagttggat aactgttgat gagaagcaaa ctgtatagcc tcccaacatt
     3301 gtccttcatt taactcacca tctccaacaa tagcataagt ataaaaggga ctctttctta
     3361 ttctctgacc atatgcaagt ccagttgcaa cactaattcc ttgtcctaaa gagcccgttg
     3421 tcatatctat gcctggcgtt agatttctat caggatgaga cggtaatttg gttccatttg
     3481 tatttaaaga atataagaat tctttgtcaa agaaaccatt caaatagagt gtactgtata
     3541 gagctggtcc tccatgacct tttgataata tgaaataatc tctatctcgt gctgcaaata
     3601 tttctggagt cattggcatt atttcaccat aaagcactgc taaaacttct acgatagaca
     3661 gacttcctcc gtaatgtccg aatccaagat gattcaatgt tctaagagta tttaatcgga
     3721 tgttagtcgc aaattttctt aactcatctt ctctattttt acttaaaatc atcccttatt
     3781 cctcctttgc agatggcttt ttaataaagg atactccaaa cataactgct aaaataagaa
     3841 caagaccaat cacaatgcct gcttgtgagc caaattgatt taacattcct aaaataattc
     3901 ctgatagacc aaaatctgca tctgagaaag ttgatccttg gaaaccgagt cctcccaaaa
     3961 ctggcattaa aaagactggg agaaaactga ttaaaatacc ttgtaaaaat gctccaatag
     4021 tggctccacg aacaccacca gatgcattcc caataacacc tgcagttgct ccacagaaga
     4081 aatgaggcac aacacctggt aagataacaa ccgttcctga agcaatcata attgccatac
     4141 ttactaaacc accaacaaaa ctagagataa atccaattag aactgcattg ggtgcataag
     4201 tataaacaat cggacaatcc aaagcaggtt ttgaattagg tacaagacgc tctgaaatac
     4261 ctttaaaggc tggaacaatt tcgcccaaaa taaggcgaac acctgctaaa ataacaaata
     4321 cccctgctgc aaattgacct gctaattgta aagcataaac tagaccactt gtaccactac
     4381 tgatttcttt ttctatatat tctgaccctg caaagatagc tacaataatg taaataactg
     4441 ccatagataa agtgatacta acagtactat cacgtaaaaa agctaaactc tttggaaatt
     4501 taatgtcctc tgttgatttt gatttgtcac cgataaggct accagtaaaa ccactcaacc
     4561 aatatcccaa agaactgaaa tgacctaaag ccaccttgtc atttccagtt aattgaacca
     4621 tatatttttg cacaaatgct ggggaaatac tcataataat accgagtgct aatcctccta
     4681 gtaagataag aggcaagcta gtaaagccag caactgataa aatgaccgca atcatacatg
     4741 ccatatatag agtgtggtgc cctgttaaaa aaatatattt aaatcgagta aaacgagcga
     4801 ttaagatatt gaacaccatg cctgcaaaca taatcattgc agtagctgag ccatatgttg
     4861 ttaaagctac tgctacaatt gcttcattat tcggcacaac gccagataaa tgaaaagcat
     4921 gctcaaacat ggtaccaaat ggatttaaag aattttgtac aattcctgca ccaccagata
     4981 caactaagaa accaacaaag gtcttaattc cacctttaat aatatcaggt aatttcttct
     5041 tctgaagaac taatcctaaa attgcaatta aagctactaa aatagctggt gtactaacaa
     5101 tatccaatat gaacttcatc atgacgctag cctcctatat aagtcctttt tcttcacaaa
     5161 gtttagtaat taattctcgt agttcatcca tatcaataat actatttaag atacgaacat
     5221 ctccaagatg actagctgaa tcagctagat cacgaccaac aatccaaata tcagctgcat
     5281 ttggatctgc tccacctaaa tcataatgtt caacttctac atccgaaaca ttcaaatcac
     5341 tcaatacaga ttcaatattc atctgtacca taaaacttga acctaatcct gaaccacaag
     5401 ctgtaccaat ttttaacatt atctaatcct cctgtttaat tatcatttta atatcattat
     5461 agttttttga tgatattaaa gtttgaacat gatttttatc tcttaaaatt gttgttaaat
     5521 gtgacaaagc ctttaaatga ctctcattat caatggctgc aatacaaatc aacaatctta
     5581 cctcttgttc tggattatcc aataaataaa tcggttcttc caaaactaac attgacattc
     5641 ctatttcatt cacaccttca tctggccgag cgtgaggaat tgctactccc ttccctaaat
     5701 taataaaagg tccaaactct tctacttttt gaatcattgc ctcagggtag ttctcagtta
     5761 tcttatcttg atccaaaagc ggtttagctg ctaaacgaat cgcctccttc catcctaatt
     5821 tttgcgaact aacctgatag gtttctttgg taataagttg ttctagcact ggtacaattt
     5881 cctttctatc atttttttgg taaagataat tctttaacgc caatcttaat tccaattctt
     5941 gtgtaataat tccatatctt ttgacaatat tcaggatttg ttcaatctca aaatctccat
     6001 actctaaatt cggaaaatct tttaacacta gttctactag ttgtattgct tgctcttcag
     6061 tcatcataac cgaaactaga taatttggct tttctgtctc cacctttatg gtagaaaaaa
     6121 ccatatcata gtcactacta gctttcacct gtaaatcatc aatctttgag gttcctataa
     6181 actcaatttg aggaaataat gctaatagat tctcttttaa catcaatgaa gaactaacac
     6241 cattaggaca aatgattgct gctttatagc atttttgagg caaagtatct gctttcttta
     6301 aataacctcc gaaatggata acaaaatatg ctgtttcact atcaggtatg ggattgtcaa
     6361 tagcgtccat caagggcatc aaagaatctt tgactaattc aaataaatca ggataatgtt
     6421 ctttaacatg caatacatat tcatttgaac taggtaggcc gaactttaat ctatagtaag
     6481 ccggtataag gtggcggcga agattttctc tcaatccttc cctttgttta aaatgtaaca
     6541 aagaaatatc ttccattcta cttataatag cctctgttaa ttgattaaag taaaccggag
     6601 caacatctac ttcaccttca aagcaacttg ataataaaac ggtgatatag cgataatcat
     6661 cctcagaaaa caccgtatct ataattccca aatcaaccac tgtatccaat aaaatagtgg
     6721 ttatatcttg aataacagga gatactaatg tctctgaaag acatactctt tcaacatccc
     6781 tttgatacct acacagaatg aatactaaac cgaaaaggta aacttttaat tgattaacaa
     6841 taggtactag ctgtagcttc tcataataat ctttaactac ctgatcaatc aaatcataag
     6901 ttaatgaata cccccaactg gataaaacat aatccaaacc ccaaatccct atggaggatt
     6961 ccagcaactc actaaccatt tgaaaagcta agcggtgctt attccactct gaaccgtgta
     7021 aagtataacc ttttgctcta ctgtacccta gctccaaatc attatctaac ataatctttc
     7081 ttaatgattg aatatcagat aaggttgtat tcttacttac tttcaaaaag tcttggtaat
     7141 gattattcga tataaaatct aatcggcaaa aagtgtaaag atagattaaa gctaagcgag
     7201 tcgactttgg taaaaccaat tcatccgact taataatatc tgtcaaagac tgcttcgtac
     7261 gatttgataa actatagcga ccttgctttt tatccagcac tatcccttta ttagctagat
     7321 aaggcactaa ataatctatt ccttctttga cttcctttat aggtaagctc accttaacag
     7381 ataattcata taatgatagc tcacaatgat ccatcaaagt catcaaaata actagtgctc
     7441 tataatcaaa catttctctt cctttctaac tacaattata gtgtaaaaat tataagaata
     7501 aaagagtatt tgagcacaat ataatctcac cttttaaaag aaattattgg gctgaaagtt
     7561 tttagtgatt atttttcaac tttctattga ctttataaat taaagtgata tcatttagat
     7621 atcaaataac aggaggtcat tcttatgact gaaaaactaa tcaattcaaa accaaatggt
     7681 gtattcgcat tgattctcat tgagttgaca atcgtacttg gtatctttat atttataatg
     7741 ggggttggtt cggaaaacat ttttggaatt attatcggac ctttactaat cgtaattgca
     7801 ggtctagctc atgctggttt aaaagttgtc aaacctcaag aagctctggt tctgacactc
     7861 tttggtaact atacaggtac catcaaagaa cctggctttt actttgtcaa tcccttcagc
     7921 gtagcagtca accctgcaaa ccacactcga cttggacaaa gtggtgatgt tagcacaaaa
     7981 tctccttttt taggagctaa atcatcaaat gacaatgatg taaatcttga aattggcaag
     8041 aaacacattt ccctcaaagt catgaccttg agcaattctc gtcaaaaaat caatgattgc
     8101 ttaggaaacc ctgtagaaat cggtatcgcg gtaacttgga gagttgtcga taccgctaag
     8161 gcagtcttca acgttgataa ctacaaagaa tatctttcat tgcaatgtga tagcgccctc
     8221 cgtaatattg tccgcatcta tccttacgat gtgtctccta atgtggatac tacgggtgac
     8281 gggcaagcag atgaaggtag tctccgtggc tctagcgaaa ttgttgctaa ccgtattcgt
     8341 gaagaaatcc aaagtcgtgt tgaggatgct ggcttggaaa tccttgaagc acgtatcact
     8401 tacctagctt atgctccaga aattgctgcc gttatgcttc aacgccaaca agcatctgcc
     8461 attattgatg cacggaagat gattgtagat ggtgctgtag gaatggttga aatggcacta
     8521 gaacggctca atgaagggga attggtagaa cttgacgaag aacgaaaagc tgccatggtt
     8581 tcaaatctcc ttgtcgttct ttgtggcaat catgatgcac aaccaattgt caacacagga
     8641 agtctttact aaagatggct gaagctaaaa aaaagcagat cccccttcga ctctcaacaa
     8701 agttatacgc tgcactcgca tcatgggcag aagacgactt tcgttcagtc aatgggcaaa
     8761 tcgaatatct cctcacagag tgtgtcaagc aacggaaaaa agacggaaaa tacgtatcag
     8821 aaaccattga cgaaccattt gagattgata tttaacacct tctcctgtct gccgtgtcgg
     8881 ataggagaat tttttcatct ttttttgtca agtaacttta ctttacaaaa aaaatgtgtt
     8941 atcctagtat ggttgatgaa aatcagtaga ttgaatcgaa tataaatacc taaaggagaa
     9001 atcaaaatgg cagtacctgc acgtcgcact tcaaaagcga agaaaaacaa acgtcgtaca
     9061 cactacaaag taacagctcc atctgtaaac tttgacgaaa ctactggaga ttactcacgt
     9121 tctcaccgtg tatcacttaa aggatactac aaaggacgta aaatcactaa agctgcatca
     9181 gctgaataat agaagggaga taccatgcgc gtaaatatta cacttgaaca caaagaatct
     9241 ggtgaacgct tgtaccttac ttctaaaaac aaacgtaaca ctccagaccg ccttcaattg
     9301 aagaaatact caccaaaact tcgcaaacac gttgtgttta cagaagtgaa gtaagcattc
     9361 aatacgaatc aatacggaag aaaaacgctt gatcagcgtt ttttcttttt gttaatttca
     9421 ctatattgca agggaaatca ttcgaatgac tacatttttt gaaataagaa tacggattcg
     9481 gacgattaaa agtaagagaa actcaaatat aagttggggt tccttttttg tatatttttc
     9541 aaataacgcc tctacactat ttgtagcaaa ttcaccaact acagttgcat cttagttaaa
     9601 ataagttaga atatgtaagt gagtaccaga tataccaaga catcgtcacc atctaaggta
     9661 tattcaaaat acaaaagttg accaactaga tttctgaata tccttatata tccattctta
     9721 aaattggttt aaatagcgta gtcttttaaa ctagttttga gaatccaaaa aatcttccta
     9781 catatgtaag aagatttttt agttcagaat gattagattt agctaatgga tacctatcct
     9841 acccactcac cgttagcatt gactcgatag ccatcgggtg tagtcgtgtt tactaataaa
     9901 tctcctgaat tataggtata gtaccattta ccagaaactg taa
//
LOCUS       DBERMM010000058         8932 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.060, whole genome shotgun sequence.
ACCESSION   DBERMM010000058 DBERMM010000000
VERSION     DBERMM010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8932)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8932)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8932
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.060"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(64..971)
                     /locus_tag="ACL8AS_001905"
                     /pseudo
     CDS             complement(64..971)
                     /locus_tag="ACL8AS_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000603324.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
     gene            1227..3860
                     /gene="polA"
                     /locus_tag="ACL8AS_001906"
     CDS             1227..3860
                     /gene="polA"
                     /locus_tag="ACL8AS_001906"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006261 - DNA-templated DNA replication
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HGS1229711.1"
                     /translation="MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQ
                     LMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDH
                     MGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA
                     EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEYGSLEG
                     IYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGK
                     FYDEMGFKQLKQALNVSSADVSESLDFTIVDQISQDMLSEESIFHFELFGENYHTDNL
                     VGFAWSCGDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAF
                     DIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKL
                     AVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIMVKKETLLEMQAENEL
                     VIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLA
                     PIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQ
                     NIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIH
                     TSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTY
                     FERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQ
                     GSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEA
                     IQLSVPLIADENEGATWYEAK"
     gene            3945..4382
                     /locus_tag="ACL8AS_001907"
     CDS             3945..4382
                     /locus_tag="ACL8AS_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0120225 - coenzyme A binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HGS1229712.1"
                     /translation="MSQEFINPSDGVIRQYLATSKTLAVVGLSDREETTSNRVTKEMQ
                     ARGYKIIPVNPKAAGGEILGEKAYASLAEIPFPVDIVNVYRRSEFLPDVARDFLKADA
                     KIFWAQLGLESLEAKEILRDGGCDDIVMNRCIKREHTRLIEEA"
     gene            complement(4565..5575)
                     /locus_tag="ACL8AS_001908"
     CDS             complement(4565..5575)
                     /locus_tag="ACL8AS_001908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family protein"
                     /protein_id="HGS1229713.1"
                     /translation="MSFLSKNGAGILACLLISIVSWYLGGFFPVIGAPVFAIFIGMLL
                     HPFLSSYKQLDAGLTFSSKKLLQYAVVLLGFGLNISQVFAVGQSSLPVILSTISIALI
                     IAYLFQRFFALDTKLATLVGVGSSICGGSAIAATAPVIDAKEKEVAQAISVIFFFNVL
                     AALIFPTLGTWLHLSNEGFALFAGTAVNDTSSVTAAASAWDSLYQSNTLESATIVKLT
                     RTLAIIPITLFLSYWQSRQQENKQSLQLKKVFPLFILYFILASLLTTLLTSLGVSSSF
                     FTPLKELSKFLIVMAMSAIGLKTNLVAMVKSSGKSILLGAICWIAIILTTLGMQTLIG
                     IF"
     gene            5724..6893
                     /locus_tag="ACL8AS_001909"
     CDS             5724..6893
                     /locus_tag="ACL8AS_001909"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HGS1229714.1"
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTT
                     PDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATE
                     ALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAI
                     LEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAH
                     VSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTSQLIKSHQYLVTAANTMAQH
                     AAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQD
                     SFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     gene            6890..7660
                     /gene="recO"
                     /locus_tag="ACL8AS_001910"
     CDS             6890..7660
                     /gene="recO"
                     /locus_tag="ACL8AS_001910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HGS1229715.1"
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKCMFFVKHAGQS
                     KLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADAS
                     LQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVG
                     QAFDFSFKYGACLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQE
                     LRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            7657..8649
                     /gene="plsX"
                     /locus_tag="ACL8AS_001911"
     CDS             7657..8649
                     /gene="plsX"
                     /locus_tag="ACL8AS_001911"
                     /EC_number="2.3.1.274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA];
                     GO_process: GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HGS1229716.1"
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIK
                     QYLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTG
                     ALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSF
                     YAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVA
                     DVVVADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLN
                     YSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            8655..8888
                     /locus_tag="ACL8AS_001912"
     CDS             8655..8888
                     /locus_tag="ACL8AS_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HGS1229717.1"
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEF
                     ILTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
BASE COUNT         2516 a         1680 c         2221 g         2515 t
ORIGIN      
        1 acacaaaata ggctccataa tatccatagt gggtaaatcc cctatggata ttatggagcc
       61 attttacaac agtgcctcaa attcagatac tgacatacct aattgctggc tggcaacctc
      121 agaagtcaga agaccttggc gtactatgtc taggaaggca aaaagtttcc tttctgccct
      181 tccttcaact ttcccacgct ctagtccttg ttcaaggcct tcagccctag cagtttccaa
      241 ggcatagtcc tgtgctaaca agacttgttc ttctcgcata tgtagttgac taaacatttt
      301 cctgtcctcc tcggaccagc tcttgtagtc cagcagttga tttgcttggg taatggctcg
      361 ttgcggttgc tgggtaaagg gcttgttgtc gaaaaactcc aaccatggct tgcgaacctt
      421 gtctttgctg gtttctctgt attttttaat tccaagaatg ccatcttaac cagatggttt
      481 tcctgtccat tgttggtaat cgccaatacc tcacctgttg tgtcttcgcg catactaaag
      541 ctatgaaaag ccaggtcatc tgagaaataa ttactatcca cgatagcaat gacgtaaaca
      601 ggagcgatgt gtttgtagat ctagtgagta tcaccttctc gctgacgaat tttttcaaga
      661 ttttgattaa cctgactgca caggtaagcc cacaagtgat tgatgaaaaa attctgatga
      721 tggacttgaa tctcaataat tacttgagta ccgttatcca actccgccaa gacgtctata
      781 ctggtataaa aatcctgcac cgagtaaggc atggagagta atacgtgaat atcgcttccc
      841 tccaaaatgg tcacattttt tgctggcaag tccagcatat cgcgaataaa ttgacaagtg
      901 atttctggat tgctgaatat tttcttagca atcaaatcat tagttgggct gatgcccgga
      961 tgtctgagaa tcctcctatt cctccttcta tagtgagttg aaataagatg tgaataactc
     1021 tatcaggaaa gtcaaattaa tttatagaaa tattttagca gtcaaggtgt actattatag
     1081 attcaatata ctatattata gcacattttt aaatctaggt ttactaaatt ctctggctct
     1141 atctatttat tcggaaaaag tttgaaaaat acttgctcta gctcttccca atggtatttt
     1201 ttgattcttt cctttataat gggtgtatgg ataagaaaaa attattattg attgatgggt
     1261 cttctgtagc ttttcgggcg ttttttgcgc tgtatcagca gttggaccgt tttaagaatg
     1321 cggctggttt gcataccaat gcgatttatg gttttcagtt gatgttgagt catttgttgg
     1381 agcgggttga gccgagtcat attttggtgg cttttgatgc gggaaagacg accttccgga
     1441 cagagatgta tgcggactat aagggtggtc gggccaagac tcctgatgag tttcgtgagc
     1501 aatttccttt cattcgtgag ttgctggatc atatggggat tcgtcactat gagctggctc
     1561 agtatgaggc ggatgacatc attgggacgc tggataagct agcagagcag gatggttttg
     1621 atattaccat tgtcagtggg gacaaggatt tgattcagct gacggatgag catacggtgg
     1681 ttgaaatttc caagaaaggt gtggctgagt ttgaggcctt tacgccagat tacctcatgg
     1741 aagaaatggg cctcacacca gctcagttta tcgatctcaa ggcgctcatg ggtgataagt
     1801 cggataatat ccctggggtg accaaagtcg gtgaaaagac gggtattaag ctcttgctgg
     1861 agtatggttc gcttgagggg atttatgaaa atattgatgg aatgaagact tctaagatga
     1921 aggaaaatct catcaatgac aaggaacagg cctttttgtc taaaacacta gcgaccattg
     1981 ataccaaggc accgattgcg attggtttag aggacttggt ctatagtggt ccagatgttg
     2041 aaaatcttgg gaaattttac gatgagatgg gattcaaaca gctcaagcag gctttaaatg
     2101 tgtcgtcagc tgatgtgtct gagagtttgg attttactat tgttgaccaa atcagtcaag
     2161 atatgctgag tgaagagtct atcttccact ttgagctttt tggtgagaat taccatacgg
     2221 ataatttggt tggatttgcc tggtcttgtg gggataagct ctatgccaca gacaagcttg
     2281 agctgttgca agacccgatt ttcaaggatt tcttagaaaa aacatctctg agagtttatg
     2341 actttaagaa ggttaaagtt cttttgcaac gttttggtgt ggatttgcag gcgcctgctt
     2401 ttgacatccg tttggctaaa tacctccttt cgactgtgga ggacaatgaa attgcgacca
     2461 tcgctagtct ttatggtcag acttacttgg ttgatgatga aactttctac ggtaagggtg
     2521 ttaaaaaggc cattcctgaa cgtgagaaat tcttggaaca cttagcttgt aaacttgctg
     2581 ttttggtaga aacagagcct attttacttg aaaaactcag cgaaaatggg caattagagc
     2641 ttctttatga tatggagcaa cctctggctt ttgtccttgc caagatggaa attgctggga
     2701 ttatggtcaa gaaagagacc ttgcttgaga tgcaggctga aaatgagctt gtcattgaaa
     2761 aactgactca agagatttac gagctggctg gtgaggagtt taatgtcaac tcgcctaagc
     2821 agttgggcgt gcttctcttt gagaaattgg gacttcctct agaatacact aagaaaacca
     2881 agacaggtta ttcgacagca gtggatgttt tggagcgtct cgctcctatt gctccgattg
     2941 ttaagaaaat cctggattac cgtcaaattg ctaagattca atctacttat gtaattggct
     3001 tgcaggactg gattttggct gatggaaaga ttcatactcg ctatgtgcag gatttgaccc
     3061 agaccgggcg tttgtctagt gtggatccaa acttgcaaaa tattcctgcc cgattggaac
     3121 aggggcgctt gattcggaag gcttttgtgc cagagtggga ggatagtgtg ctactcagct
     3181 ctgactattc acagattgaa ttgcgcgttt tggcgcatat ttctaaggat gagcacttga
     3241 ttaaggcctt ccaagagggg gcagatatcc atacttcgac agccatgcgg gtctttggca
     3301 ttgagcgtcc tgatgatgtg actgcaaacg accgtcgcaa tgccaaggca gttaactttg
     3361 gagtggttta tgggatttca gactttggct tgtctaataa tttgggaatt agtcgtaagg
     3421 aagccaaagc ctacattgat acctactttg aacgttttcc aggtattaaa aactacatgg
     3481 atgaagtggt gcgggaggcg cgtgataagg gctatgtaga gaccctcttt aagcgtcgcc
     3541 gtgagttgcc agatatcaat tcgcgcaact tcaatattcg tggttttgcg gaacgaactg
     3601 ctatcaactc acctatccag ggttcggcag cagatattct caagattgcc atgattcagc
     3661 tggataaagc cttggttgca ggtggttatc agactaagat gctgttacaa gtgcacgatg
     3721 aaatcgtcct tgaagtgcct aaatctgaat tggtagagat gaaaaaattg gtgaaacaaa
     3781 ccatggaaga agccattcaa ctcagtgttc ctcttatcgc agatgagaat gaaggggcaa
     3841 cctggtacga ggctaaataa aaagggggct agtcctcctt ttttgtagta taattctgca
     3901 aaccttttca aaatgtgcta tactgatgaa aaaggaggat ttctatgagt caagaattta
     3961 tcaatccaag tgatggcgtg attcgtcagt atctcgcaac gagtaaaacc cttgctgtgg
     4021 tgggtttgtc tgaccgtgaa gaaacaacca gcaatcgagt aacaaaggaa atgcaggctc
     4081 ggggctataa aatcatccca gtcaatccca aggcggcagg tggcgaaatc ttgggtgaaa
     4141 aggcttatgc tagcctcgct gaaattcctt ttcctgtaga tattgtcaat gtttatcgtc
     4201 gcagtgaatt tctgcccgat gtggcgcgtg attttctcaa agctgatgcc aagatttttt
     4261 gggcacagct aggacttgaa agtttagaag cgaaagagat tttgcgtgat ggtggatgtg
     4321 atgatatcgt gatgaatcgc tgtatcaaga gagaacatac tcgcttgatt gaggaagcat
     4381 aagaaaaagg tagctgatgg gctacctttt gtgttatact caatgaaaat caaagagcaa
     4441 actaggaaac tagccgcggg ctgctcaaaa caccgttttg aggttgcaga tagaactgac
     4501 gaagtcagta acatatatac ggcaaggcga cgttgacgtg gtttgaagag attttcgaag
     4561 agtgttagaa aatgccgata agggtctgca taccaagagt ggtgaggatg atggcaatcc
     4621 agcagatggc tccaagaaga atggattttc cactggattt gaccatagcg accagattgg
     4681 ttttgagacc gatagcactc atggccatga caataaggaa tttagagagt tctttgagag
     4741 gagtaaagaa actactggac acacctagag aggtgagtag tgtagtgagg agagaggcaa
     4801 ggataaagta aaggataaaa agtgggaaga cttttttcag ttgcaggctt tgcttgtttt
     4861 cttgttggcg actttgccag taggatagaa agagcgtgat agggataatg gccaaagtac
     4921 gtgtgagttt aacaatggtt gcagactcga gggtattgct ttggtaaaga ctgtcccaag
     4981 cgctggcggc agccgttaca gaggaagtgt cgttgaccgc agtccctgca aagagggcga
     5041 agccttcatt ggatagatga agccaggtgc cgagggttgg aaagatgagc gcagccaaga
     5101 cattgaagaa aaagataacg gaaatggctt gggctacttc cttttcctta gcatcaataa
     5161 cgggcgctgt cgctgcaatg gcagaacccc cacagataga agaacctact ccaaccaagg
     5221 tagccagttt tgtatccagg gcaaagaaac gctggaagag gtaggcaata atcagagcta
     5281 ttgagatagt ggacaggatg acagggagtg aagattggcc aactgcgaag acctgcgaga
     5341 tattgagacc aaaaccaagc aagacaacgg catattggag caacttcttg gaactaaagg
     5401 tcaaaccagc atccagttgt ttataggacg agagaaaggg atgtaggagc atgcctatga
     5461 aaatggcaaa aacgggcgcg ccaatcacag ggaagaatcc tcctaagtac caagatacga
     5521 tagaaatgag aaggcaggcc aagatacctg ctccattttt tgatagaaat gacataaaaa
     5581 cctccaaata aaatctatta ccattataga cctataaaca ggaaaagtaa aatagaaagt
     5641 ggaaagctat cctctaatgt atttttgcgg tcggggggct tttgtagtat aatagagata
     5701 cgttttgaaa gtaggaggta tctatggact taactaagcg ctttaataaa cagttagata
     5761 aaattcaagt ttcgttgatt cgtcagtttg accaggctat ttcggagatt cctggggtct
     5821 tgcgtttgac cttgggggaa cctgatttta caacgccaga ccatgtcaag gaggcggcca
     5881 agcgagcgat tgatcagaac caatcctact atacagggat gagtggtctg ctgactctac
     5941 gtcaggcagc tagtgacttt gttaaggaaa agtaccaact ggactatgct cctgaaaatg
     6001 aaatcttggt tacaattggg gcgacagagg ctttatctgc gactttgacg gctattttgg
     6061 aagagggaga caaggtactt ttgccagctc ctgcttatcc aggctatgaa ccgattgtta
     6121 acttagttgg ggcagaaatt gttgagattg atacgactga aaatggtttt gtcttgactc
     6181 ctgagatgtt ggagaaggcc attttggagc agggtgataa gctcaaggcg gttattctca
     6241 actatccagc caatccgaca ggaattacct acagtcgaga gcagttagag gccttggcag
     6301 ctgttttacg caagtacgaa atttttgttg tctgtgatga ggtttactca gaattgacct
     6361 acacaggcga agcccatgtg tctctaggaa cgatgttgag agaccaggct attattatca
     6421 atggtttgtc taaatcgcat gccatgacag gttggcgttt ggggctgatt ttcgctcctg
     6481 cggccttcac atcccagtta atcaagagtc accaatactt ggtcactgcc gcaaatacca
     6541 tggcgcaaca tgctgcggta gaagccttga cggctggtaa aaatgatgcg gagcccatga
     6601 agaaggaata tatccagcgt cgggactata tcatcgaaaa aatgactgct cttggttttg
     6661 agattatcaa accagacggt gccttctata tttttgctaa aattccagcg ggctacaatc
     6721 aagactcctt tgcttttctg aaggattttg ctcagaagaa ggccgttgcc tttatccctg
     6781 gtgcagcctt tggacgttac ggggaaggct acgtccgcct atcttatgca gccagcatgg
     6841 agactatcaa agaagccatg aaacgacttg aggagtatat gagagaagca tgattcagtc
     6901 tatcacgagt caaggcttgg tgctttacaa tcgcaatttt cgtgaggatg acaagcttgt
     6961 caaaattttt acagagcagg ttggcaaatg catgtttttt gtcaaacacg ctggtcagtc
     7021 taagctggcg cctgttattc agcccttggt gctggcacga tttctcttgc gaatcaatga
     7081 tgacggactc agttacatcg aagactatca tgaggtcatg acttttccca agattaatag
     7141 tgacctcttt gtcatggcct atgcgaccta tgtggcagct cttgcagatg ctagtttgca
     7201 ggacaatcag caggatgctc ccttgtttgc ttttttgcaa aagactttgg agttgatgga
     7261 agcaggcttg gattatcagg ttttgaccaa tatttttgaa attcaaattt tgactcgatt
     7321 tggaatcagc ctcaatttta atgagtgtgt cttctgccat cgggttggtc aggcttttga
     7381 cttttctttc aaatatggag cctgtctctg tccagagcat tatcatgagg atgagagacg
     7441 ttgccatctc aatcccaata tcccctatct gctcaatcaa tttcaagcta ttgattttga
     7501 gactttggag accatttcgc tcaagcctgg aatcaagcaa gagctacgcc aatttatgga
     7561 tcaactatat gaagagtacg ttgggattca cctaaaatca aagaaattta ttgattccct
     7621 agcagactgg ggacaattac taaaagagga aaagaaatga aaaaaatcgc agtagatgcc
     7681 atggggggcg attacgcacc tcaggccatc gttgagggtg tcaatcaagc cctatctgac
     7741 ttttcagata tcgaggttca actctacgga gatgaagcta aaatcaagca atatctgaca
     7801 gcgacagagc gcgtcagcat tatccatacg gatgagaaga ttgattcgga tgatgaacct
     7861 acgagagcta ttcggaataa gaaaaatgcc agtatggtat tggcagccaa ggctgtcaaa
     7921 gatggtgaag cagacgctgt cctttcggct gggaatacag gtgctttgtt ggctgctgga
     7981 ttcttcatcg tgggtcgtat caagaatatc gaccgtcctg gacttatgtc aacattgccg
     8041 actgtagatg ggaaaggttt tgacatgctt gacctcggtg ctaatgcaga aaatacagcc
     8101 cagcacctcc atcaatatgc ggttctaggt tccttctatg ctaaaaatgt ccgtggcatt
     8161 gcgcaaccac gcgttggttt gctcaacaac ggaacagaga gtagcaaggg cgacccgctt
     8221 cgtaaggaaa cttatgaatt actggcggct gatgaaagtt tgaactttat cggaaacgtg
     8281 gaagcgcgtg atttgatgaa tggcgttgca gatgttgttg tggcagatgg tttcacggga
     8341 aacgctgtgc tcaaatccat cgaagggaca gctatgggaa tcatgggctt gctcaagaca
     8401 gctattacag gtggtggtct tcgagcgaaa ctaggtgccc tccttctcaa ggacagcctc
     8461 agaggtttga aaaaacagct caattattca gatgttggtg gagcggtctt gtttggtgtt
     8521 aaggcacctg ttgtcaagac tcatggctca agcgatgcca aggctgttta tagtacgatt
     8581 cgtcagatcc gtaccatgct agaaacagac gtggttgccc agactgcgcg tgaattttca
     8641 ggagaataaa agagatgaca gaaaaagaaa tttttgaccg tattgtgacc attatccaag
     8701 agcgacaggg agaggacttt gtcgtgacag aatccttgag tctgaaagac gatttggatg
     8761 cggattctgt tgacttgatg gagtttatct tgactctgga agatgaattt agtatcgaaa
     8821 tcagcgatga agaaattgac caactccaaa acgtaggaga tgtggttaaa atcattcaag
     8881 gaaaatagca atcggagttc caagtcaacg gaagtagatg gtttttagaa at
//
LOCUS       DBERMM010000059         8764 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.061, whole genome shotgun sequence.
ACCESSION   DBERMM010000059 DBERMM010000000
VERSION     DBERMM010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8764)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8764)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8764
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.061"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(226..1194)
                     /locus_tag="ACL8AS_001913"
     CDS             complement(226..1194)
                     /locus_tag="ACL8AS_001913"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004749 - ribose phosphate diphosphokinase
                     activity [Evidence IEA];
                     GO_process: GO:0009156 - ribonucleoside monophosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HGS1229718.1"
                     /translation="MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQV
                     NIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRK
                     ARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERR
                     GMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGK
                     TCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVL
                     DTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI"
     gene            complement(1339..1993)
                     /locus_tag="ACL8AS_001914"
                     /pseudo
     CDS             complement(1339..1993)
                     /locus_tag="ACL8AS_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749763.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family glutamic-type intramembrane
                     protease"
     gene            complement(2018..2515)
                     /locus_tag="ACL8AS_001915"
     CDS             complement(2018..2515)
                     /locus_tag="ACL8AS_001915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-class carbonic anhydrase"
                     /protein_id="HGS1229719.1"
                     /translation="MSYFEQFMQANQAYVALHGQLNLPLKPKTRVAIVTCMDSRLHVA
                     QALGLALGDAHILRNAGGRVTEDMIRSLVISQQQMGTREIVVLHHTDCGAQTFENEPF
                     QEYLKEELGVDVSDQDFLPFQDIEESVREDMQLLIESPLIPDDVIISGAIYNVDTGSM
                     TVVEL"
     gene            complement(2588..3949)
                     /gene="radA"
                     /locus_tag="ACL8AS_001916"
     CDS             complement(2588..3949)
                     /gene="radA"
                     /locus_tag="ACL8AS_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016893792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003684 - damaged DNA binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HGS1229720.1"
                     /translation="MAKKKATFVCQNCGYNSPKYLGRCPNCGSWSSFVEEVEVAEVKN
                     ARVSLTGEKTKPMKLAEVTSINVNRTKTEMEEFNRVLGGGVVPGSLVLIGGDPGIGKS
                     TLLLQVSTQLSQVGTVLYVSGEESAQQIKLRAERLGDIDSEFYLYAETNMQSVRAEVE
                     RIQPDFLIIDSIQTIMSPEISGVQGSVSQVREVTAELMQLAKTNNIAIFIVGHVTKEG
                     TLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNP
                     SQVFLEERLDGATGSSIVVTMEGTRPILAEVQALVTPTMFGNAKRTTTGLDFNRASLI
                     MAVLEKRAGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKDKPTNPQECFVGE
                     LGLTGEIRRVNRIEQRINEAAKLGFTKIYVPKNSLTGITLPKEIQVIGVTTIQEVLKK
                     VFA"
     gene            complement(3963..4478)
                     /locus_tag="ACL8AS_001917"
     CDS             complement(3963..4478)
                     /locus_tag="ACL8AS_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HGS1229721.1"
                     /translation="MKIIFVRHGEPDYRELEERSYIGFGIDLAPLSEMGRQQVQKLSK
                     NPLLSSAEIIVSSAVTRALETASYVVCATGLPLRVEPLLHEWQVYKTGIENFETARRL
                     FLENKGELLPNSPIQYETATEMKSRFLECMSKYREHQTVVVVAHRMLMRQFVPNEKID
                     FCQVIECELEI"
     gene            complement(4480..4923)
                     /locus_tag="ACL8AS_001918"
     CDS             complement(4480..4923)
                     /locus_tag="ACL8AS_001918"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HGS1229722.1"
                     /translation="MKIRGFELVSSFTDENLLPKRETAHAAGYDLKVAVRTVVAPGEI
                     VLVPTGVKAYMQPTEVLYLYDRSSNPRKKGLVLINSVGVIDGDYYGNPGNEGHIFAQM
                     KNITDQEVVLEVGERIVQAVFATFLIADGDAADGVRTGGFGSTGH"
     gene            complement(4980..5077)
                     /gene="ffs"
                     /locus_tag="ACL8AS_001919"
     ncRNA           complement(4980..5077)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="ACL8AS_001919"
                     /product="signal recognition particle sRNA small type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00169"
     gene            complement(5110..5577)
                     /gene="tadA"
                     /locus_tag="ACL8AS_001920"
     CDS             complement(5110..5577)
                     /gene="tadA"
                     /locus_tag="ACL8AS_001920"
                     /EC_number="3.5.4.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008251 - tRNA-specific adenosine
                     deaminase activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0002100 - tRNA wobble adenosine to inosine
                     editing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA adenosine(34) deaminase TadA"
                     /protein_id="HGS1229723.1"
                     /translation="MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRG
                     HNAREELQRAVMHAEIMAIEDANLSKESWRLLDCTLFVTIEPCVMCSGAIGLARIPNV
                     VYGAKNQKFGAAGSLYDILTDERLNHRVEVEIGILEDECAAIMQDFFRNRRKK"
     gene            complement(5778..7064)
                     /locus_tag="ACL8AS_001921"
     CDS             complement(5778..7064)
                     /locus_tag="ACL8AS_001921"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000205044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HGS1229724.1"
                     /translation="MTSVVVVGTQWGDEGKGKITDFLSANAEVIARYQGGDNAGHTIV
                     IDGKKFKLHLIPSGIFFPEKISVIGNGMVVNPKSLVKELSYLHEEGVTTDNLRISDRA
                     HVILPYHIELDRLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFRERL
                     ERNLAEKNRLFEKLYDSKAIVFDDIFEEYYEYGQQIKKYVIDTSVILNDALDNGKRVL
                     FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKIDKVVGVCKAYTSRVGDGP
                     FPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVL
                     SGLDTVKICVAYDLDGQRIDYYPASLEQLKRCKPIYEELPGWSEDITGVRNLEDLPEN
                     ARNYVRRVSELVGVRISTFSVGPGREQTNILESVWS"
     gene            complement(7295..7531)
                     /gene="comW"
                     /locus_tag="ACL8AS_001922"
     CDS             complement(7295..7531)
                     /gene="comW"
                     /locus_tag="ACL8AS_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma(X)-activator ComW"
                     /protein_id="HGS1229725.1"
                     /translation="MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVR
                     YGIGCRRDFIVYHYRVAYRLYLEKLVMNRGFISC"
     gene            7796..8569
                     /locus_tag="ACL8AS_001923"
                     /pseudo
     CDS             7796..8569
                     /locus_tag="ACL8AS_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436304.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(8688..8761)
                     /locus_tag="ACL8AS_001924"
     tRNA            complement(8688..8761)
                     /locus_tag="ACL8AS_001924"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(8725..8727),aa:Asn,seq:gtt)
BASE COUNT         2795 a         2105 c         1398 g         2466 t
ORIGIN      
        1 ttgaaacgac tggtatacct actagaattc tccttagaaa gcgtcgattc aagtgctatc
       61 actgttcaaa aatgatggtc gctgaaactt ctgatgacgt acagtcatat ttcttctctt
      121 tttattatat cacagtttta aatctagctt tactagattc accgctacta tctatttatt
      181 cggaaaaaag acgaaaaaac ctgagaatca tctcaggctt ggtcattaaa tttttttctc
      241 aatatcgaaa agtggagaaa gtggtcgttt ttcatgaata cgtacgatag catcccctag
      301 gagatgagcg attgaaatct gctcaatctt atcaatcaaa cgctcttctg gcagatagat
      361 ggtatccaaa acaaccaatt tcttaatagc tgatttttgg atattgtccg tagcaggacc
      421 agaaagaact gggtgcgtac agcttgcata gacttcaaca gcaccagctt ccgcaagagc
      481 atctgccgca tgacaaatcg ttccagcggt atcaatcata tcatcaatca agatacaagt
      541 cttgccttca accttaccga tgatgttcat aacttcacta gtattcatct tatcaacgct
      601 acgacgttta tcaataatag cgatagatgt tttcaaaaat tctgccaact tacgagcacg
      661 agtcacccct ccatggtccg ggctgacaac cacatagtca gaaccaacca taccacgacg
      721 ctcaaaataa tctgcaatca gaggagcacc catcaaatga tccacaggaa tatcaaagaa
      781 tccttgaatt tgcgcagcat gcaagtcgat ggtcaataaa cgatccactc cagctacttc
      841 aagcatattt gcgacaagtt ttgaagtgat tggctcacgc gctctcgcct ttctatcctg
      901 acgtgcatac ccatagtaag gcatgacaac attgacagat tctgcactcg cacgcttcaa
      961 agcatctacc ataatcaaaa tttcaagcag attgtcattt acaggcgaac tagttgattg
     1021 taggataaag acgtgtttcc cacggattga ttcttcaatg ttgacctgaa tctctccatc
     1081 tgaaaattgg cgaacacttg atttccccaa ctctatccca atctcctgcg ccacacgttc
     1141 tgccaattct ttattagaag aaagggcaaa cagctttaaa tcagaaaaag acatgatttc
     1201 ctccggtata tatgtatcgc ttgtgctttt cacaagattt tccatctacc attgtagcgc
     1261 tttttgcact atttttcaat caaaaataaa agaagggcac catatttgta cccttgcatc
     1321 attcttttga aaaatattct aggtcatcaa ctcattgtgt ttctcaacaa agcaataagc
     1381 atgataataa ccatagagag caatagccgt aaccactgga atcgctaaag gcaactctgt
     1441 ttccaactcc acaaaaggag agttaaacaa taagaccctg tttcttgcca accttctgtc
     1501 ctttataggc tctgtaaagc aagtaaacac ctactacagc tagacctgaa aaagtccagt
     1561 gagaggcaat tccaagtaaa aacaaaaatt ttaattttcg cacaggaatc aaagccaaaa
     1621 caaaaacaag tggcaataat ttcaagggtt cttctaccaa aggagccaca atagcacttt
     1681 caaaggcatt taaaaatgga ctatctggga aaagaacccc cagtaaatca tgtatataag
     1741 tattagcaaa actagacaac cagcctgaaa ggaacatccc tcccaataaa gacagaatca
     1801 aaaccttctt tggcaattcc cattttttcc caatatggaa gagaaaataa agagccggaa
     1861 tcatgtaaaa gagagctaga aagatagaaa ctcccattag tccatattcc gcacctgacc
     1921 tcgaaccgtc cgtatagtag atggtttcat actgtaaacc aatacatagc aataaaatac
     1981 tgcttttctt catacacttt ctttctaaat gaagtattta taattctacg actgtcatac
     2041 ttcctgtatc aacattgtaa atagcaccag agataatgac atcgtctggt attaggggag
     2101 actcgataag cagttgcata tcctcgcgta cactctcttc tatatcttgg aagggcaaga
     2161 aatcctggtc tgacacatct acacctaatt cctcttttaa atactcctga aaaggttcat
     2221 tttcaaaggt ctgagcacca cagtctgtat ggtgcaatac cacaatctct cttgtcccca
     2281 tttgttgctg ggaaataact agcgaacgaa tcatgtcttc agtcactcga ccacctgcat
     2341 tccgcaagat atgagcatcc ccaagtgcca agcccagagc ttgcgcaacg tgcagacgag
     2401 agtccataca ggtcacaata gctactcttg ttttgggttt aagtggcaga tttaactgcc
     2461 catgtagggc aacataagcc tgattagctt gcataaactg ttcaaaatac gacacgattc
     2521 cctccttgaa aatttgatag tcaaatattt ctcctatctt atcattttta agagaatttg
     2581 tcacggatta tgcaaagacc tttttcaaaa cttcctgaat cgttgtcacg ccaatgacct
     2641 gaatttcctt aggcagagtg attcctgtca aggaattctt aggtacataa atcttagtaa
     2701 agcccagttt agcagcttcg ttgatgcgtt gctcaatacg attcacgcgc cgaatctctc
     2761 ctgtcaagcc cagttctccg acaaaacatt cctgaggatt agttggcttg tctttgtagc
     2821 tcgaagcaat agcaactgca acagccaagt caatggcagg ttcatccaat ttaacaccac
     2881 cagcagattt gagataggca tcctgatttt gcaagagaag ccctgcccgt ttttccaaaa
     2941 cagccataat caagctagca cggttaaaat caagtcctgt cgtagtacgc ttggcatttc
     3001 caaacatggt cggtgttacc aaagcctgaa cctccgccaa aatcggacgc gtcccttcca
     3061 tggttacaac gatggaggaa ccagtcgccc catccaaacg ctcttctagg aaaacttgac
     3121 tcggattgag tacctcaacc aagccgcccg actgcatctc aaaaatccca atctcattag
     3181 tggaaccaaa acgatttttg accgctctca aaatacgaaa ggtgtggtga cgctcccctt
     3241 caaagtaaag caccgtatcc accatatgct ccaacatacg aggcccagcc aaggttcctt
     3301 ctttggtcac atgacctacg ataaagatgg caatgttatt ggtcttggcc aactgcatga
     3361 gttcagcggt cacttcacgc acctgagaaa cagacccctg cacccctgaa atctcaggag
     3421 acatgatggt ctggatggaa tcaataatga gaaagtctgg ctgtatacgc tccacttctg
     3481 cacgaacact ctgcatattg gtctctgcat agagataaaa ctcactatca atatcaccta
     3541 agcgctctgc acgtagttta atctgctggg cagactcctc cccactgaca tagagaactg
     3601 tccccacttg ggacaactgg gttgagactt gtaggagaag agttgatttc ccaatcccag
     3661 gatccccacc gatgaggacg agacttcctg gtaccactcc gcctccaagc acacggttga
     3721 attcctccat ctccgtcttg gttcgattga cattgatgga agtcacctca gctagtttca
     3781 tgggcttggt tttctcacct gtcaaggaca cacgcgcatt cttgacctcg gcaacctcaa
     3841 cctcttccac aaaagaagac caagacccac agttggggca acgtcccaga tatttagggg
     3901 aattataccc acaattttga catacaaatg tcgctttttt ctttgcgatg acaaacctct
     3961 ttctatatct ctaactcaca ctcaatcact tggcaaaaat caatcttctc atttggcaca
     4021 aactggcgca tgagcattcg atgagcaaca actaccacag tctgatgttc tcgatactta
     4081 gacatacatt ctagaaaccg agacttcatt tccgtagctg tctcatattg aataggacta
     4141 ttaggaagca actccccctt gttttctaaa aacagtcttc tagctgtttc aaagttttct
     4201 attcctgttt tatagacctg ccattcatgt aataaaggct ctactcttaa aggaagaccc
     4261 gtagcacaga ccacatacga agccgtttct aaagctcttg tgactgcaga agatacgatt
     4321 atttcagctg acgagagtaa aggatttttg ctcaatttct ggacttgctg ccgtcccatc
     4381 tcagacaagg gtgccaaatc tatcccaaat cctatataag aacgctcctc taactcacgg
     4441 taatctggct ccccatgacg tacaaagata atcttcattc tagtgccctg tcgatccaaa
     4501 tccaccagtt cgaacgccat cagctgcatc tccatctgca attaagaaag tagcaaaaac
     4561 agcctggaca atacgttccc caacttcaag aacaacctct tggtctgtga tattcttcat
     4621 ctgcgcaaaa atatgccctt catttccagg atttccataa taatccccat caatgacccc
     4681 aactgagtta attaaaacca agcccttctt acgaggattt gaagaacgat catagaggta
     4741 gagaacctca gtcggctgca tataagcctt aacccctgtc ggaaccaaga caatctctcc
     4801 tggcgcaaca actgtacgca cagcaacctt taagtcgtaa ccagccgcat gcgctgtctc
     4861 acgcttgggc aataaatttt catctgtaaa actcgaaacc aattcaaaac cacgaatttt
     4921 cataattttc tcttttctat tatcatttat tctagattat tctatcttat ttattcggaa
     4981 aaagcacgaa aaaaagagca cacaattcaa atcgcttagg gctgctggat tcctcccctg
     5041 acccgcttca cgcagaactg ttgctccact atttattata tcacattcct attcatttta
     5101 aaagcaaaat tattttttcc gtctatttct aaaaaaatcc tgcatgatag ctgcgcattc
     5161 atcttccaaa attcctattt caacctccac acgatgattg agacgctcat ctgtcaagat
     5221 atcgtacaaa ctcccagcag cgccaaattt ctggttttta gccccataga ccacatttgg
     5281 aatgcgggca agcccaatcg ccccactaca catgacacaa ggttcaatgg tcacaaaaag
     5341 tgtgcaatcc agcaagcgcc agctctcctt actcaagttc gcatcctcta tagccataat
     5401 ttccgcatgc ataaccgctc gctgtaattc ctcacgcgca ttatgcccac gaccaatgat
     5461 ttccccatct ttgacaatca cacaaccaat tggaatttca tcgtgttcaa gagcaatctc
     5521 agcctctctc aaagcctccc tcataaagac ttctttttct tcaagcgtat aatacatctc
     5581 ttttctcttt tcctacttat cgattttatt attatatcat gaatcccaac acaaaagaag
     5641 ccaccgaatg cggtgactct atagggagat tattatgaaa aagaaaagtt taggatattt
     5701 gttacaacaa gttaggaggt cttcttgtaa ccgtctatag tatacccgac ctatcttaaa
     5761 caaatcttaa aaatctctta ggaccaaaca ctttctaaaa tatttgtttg ttcacgacca
     5821 ggacctactg agaaagtaga aatacgaacg ccaaccaatt cactcacacg acgaacatag
     5881 ttacgcgcat tctcaggaag atcttccaaa ttgcgaactc cggtaatatc ttctgaccaa
     5941 cctggcaact cttcatagat aggcttgcaa cgtttcaatt gctcaagact agctggatag
     6001 tagtcaatac gttgaccgtc aagatcatag gccacacaga ttttcacagt atccaaaccg
     6061 ctcaaaacat caatagagtt caaagaaagg ttagtaatac cagaaacacg acggctatga
     6121 cgcatcacaa ctgagtcaaa ccaacctaca cgacgtggac gaccagttgt tgtaccatac
     6181 tcatgaccca cttcacggat acgttctccc acttcatcaa acaactcagt tgggaaagga
     6241 ccatctccta cacgactcgt ataagcttta catacaccta caaccttgtc aatcttgctt
     6301 ggaccgacac cagaaccaat tgtcacacca ccagctacag ggtttgatga cgtaacaaat
     6361 ggataagtac cttggtcgat atctagcata acaccttgtg caccttcaaa aagcacacgt
     6421 ttgccattat caagcgcatc attcaagata acagatgtat ctatcacgta tttcttgatt
     6481 tgttgaccat attcgtaata ttcttcaaaa atatcatcga aaacaatcgc tttactgtca
     6541 tacaattttt caaaaagacg attcttttca gcaaggttac gttctaaacg ctcacggaaa
     6601 atatctttat ctaaaagatc tgcaatacga attccaacac gagcagcctt gtccatataa
     6661 gctggaccaa ttcccttaat tgtcgtacca atcttattgt cgcccttagc ttcttcttgc
     6721 aagcgatcca actcgatatg ataaggcaaa ataacatgcg cacgatcaga aatacgcaag
     6781 ttatcagttg ttacaccttc ctcatgaaga tagctcaact cttttacaag agatttagga
     6841 tttacaacca taccattccc aatgacagat attttttcag ggaagaaaat cccagatgga
     6901 atcaagtgca acttaaattt cttaccgtca atcacaatcg tgtgaccagc attatcacca
     6961 ccttggtaac gtgcaattac ttctgcattc gctgaaagga agtctgtaat cttcccttta
     7021 ccttcatcac cccattgggt acctacaaca acaactgaag tcataatttt gtctgagccc
     7081 tcaggctctt cctttctcac atacatggca ggactctcac ctgcaattat atcttacaat
     7141 ttattataat aaaaaatcgc ctttttatca agaagaaaca atagaaagat ttgctatttc
     7201 caactattaa aaaatgattt agaaaaatta ctagctattt actattatct ttccataaaa
     7261 gagtaaatta gttcggaaat ttactaaaat tacctcaaca agaaataaac ccccgattca
     7321 ttaccaattt ttcaagatac aaacgataag caacacgata atggtaaacg ataaaatccc
     7381 tacgacaacc aatgccatat ctcactaaat aataaattaa aaatttaaaa tgaacatgtt
     7441 cccagtcaaa attatcacca aatgtaggac catactcttc ttcaatacta tcatagaaat
     7501 tagccatctg ctcataaatt ttttgtaaca taatcaaata ctccttttct tttttataaa
     7561 cttattctaa caaaaaattt tacacattca ctatcaattc ctgaattgtt aaaataccag
     7621 cctcaacaag ataaaaatag gaaaagttga caaaatagaa acaaatttgc tacctaaatt
     7681 tcaaacgatt aaagttctaa aaagaccgcc ttaaaacttt tgggtaaatc ctattagaac
     7741 tataatattt ttatataggt attatggttc tgattttcta gtataaaaaa ttcaaactag
     7801 aattcttctt agaaaaggcc gttttaagtg ctatcactgt tcaaaaatga gggtcgctga
     7861 aacttctatc gtcaagaaga atcatcaaat tccttgtatc atcaaccaaa agattgctca
     7921 gaagctaatt aaaaagactt ctatgaccga cattgatcat cagttgtcta tttcaacttc
     7981 aactgtcatt cgcaagatca atgattttca ctttgagcat gatttttcgc gtcttcctga
     8041 gattatgtcc taggacgttg aaacagtccg gggagtgact gtttcaatcg ggagatggag
     8101 atgagcttta ttgctcaaga ctttgataag ctcaatatca taactgttct tgagagcaga
     8161 acacaagcca tcatccgaaa tcccatgaat acaaggctat caagcgatac tgaaagctca
     8221 ttcaacaaga tagtcagaaa ctgagtgata aacgatttta tcgccctact tttcgtatgc
     8281 acttgactaa taaagaaatt ctagataaac ttttgagcta ttccgaagac ttgaaacacc
     8341 actataatct ctatcagctc ttgcttttcc acctcttttt cagactctgt ttaaaacctt
     8401 cctcaaagat aaagaaaaaa tcgtcaacgg ccttcaatta ccttattcca acgccaaact
     8461 ggaagccacc aataatctca tcaaacttat caagtacaat gcctttggtt ttaggaactt
     8521 tgaaaacttc aaaaaagaaa ggacgaaatt tgtcctttct caagcttagc ttttcttcaa
     8581 cccactacag ttgacaaaga gccactattt ttggttcatt ttactataac acgaaataga
     8641 ttattattac ataataaaaa agaggtctaa acctcttaac taaattactc cgccagtagg
     8701 actcgaacct acgacatcat gattaacagt catgcgctac taccaactga gctatggcgg
     8761 atta
//
LOCUS       DBERMM010000060         8619 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.062, whole genome shotgun sequence.
ACCESSION   DBERMM010000060 DBERMM010000000
VERSION     DBERMM010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8619)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8619)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8619
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.062"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            184..1203
                     /gene="galE"
                     /locus_tag="ACL8AS_001925"
     CDS             184..1203
                     /gene="galE"
                     /locus_tag="ACL8AS_001925"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HGS1229726.1"
                     /translation="MQEKILVTGGAGFIGTHTVIELIQAGHQVVVVDNLVNSNRKSLE
                     VVERITGVEIPFYEADIRDTDTLRDIFKQEEPTGIIHFAGLKAVGESTRIPLAYYDNN
                     IAGTVSLLKAMEENNCKNIIFSSSATVYGDPHTVPILEDFPLSVTNPYGRTKLMLEEI
                     LTDIYKADSEWNVVLLRYFNPIGAHESGDLGENPNGIPNNLLPYVTQVAVGKLEQVQV
                     FGDDYDTEDGTGVRDYIHVVDLAKGHVAALKKIQKGSGLNVYNLGTGKGYSVLEIIQN
                     MEKAVGRPIPYRIVERRPGDIAACYSDPAKAKAELGWEAELDITQMCEDAWRWQSKHP
                     NGFED"
     gene            1205..2170
                     /locus_tag="ACL8AS_001926"
     CDS             1205..2170
                     /locus_tag="ACL8AS_001926"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HGS1229727.1"
                     /translation="MMISIIVPCLNEEEVLPLFYQALEALLPDLETEIEYVFVDDGSS
                     DGTLELLKAYREQNPAVHYISFSRNFGKEAALYAGLQYATGDLVVVMDADLQDPPSML
                     FEMKNVLDKNVDLDCVGTRRTSREGEPFFRSFCAVLFYRLMQKISPVALPSGVRDFRM
                     MRRSVVDAILSLTESNRFSKGLFAWVGFKTYYLDYPNVERQAGKTSWSFRQLFFYSIE
                     GIINFSDFPLIIAFVAGLLSCFLSLLMTFFVVVRTLILGNPTSGWTSLMAVILFLGGI
                     QLLTIGILGKYISKIYLETKKRPLYLIKEKSDLPDFTEKNKVKRL"
     gene            complement(2221..2427)
                     /locus_tag="ACL8AS_001927"
     CDS             complement(2221..2427)
                     /locus_tag="ACL8AS_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005506 - iron ion binding [Evidence IEA];
                     GO_function: GO:0009055 - electron transfer activity
                     [Evidence IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HGS1229728.1"
                     /translation="MKITLIPERCIACGLCQTYSDLFDYHDNGIVRFYDDPDQLEKEI
                     SPSQDVLEAVKNCPTRALIGNQEA"
     gene            2479..2955
                     /locus_tag="ACL8AS_001928"
     CDS             2479..2955
                     /locus_tag="ACL8AS_001928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1386/EF1546 family surface-associated
                     protein"
                     /protein_id="HGS1229729.1"
                     /translation="MAKEPWQEDIYDQEESRAERRHRNHGGADRMANRILTILASIFF
                     VIVVVMVIVLIYLSSGGSNRTAALKDFHDSDASVVQISSSSSSQPEQSSEPESTSSSS
                     EEAANPEGTIKVLAGEGEAAIAARAGISIAQLEALNPGHMATGSWFANPGDVIKIK"
     gene            2964..3635
                     /gene="cmk"
                     /locus_tag="ACL8AS_001929"
     CDS             2964..3635
                     /gene="cmk"
                     /locus_tag="ACL8AS_001929"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004127 - (d)CMP kinase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HGS1229730.1"
                     /translation="MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYM
                     ALKNQLVVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAI
                     AAIPEVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKE
                     NIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAE
                     AEKRM"
     gene            3765..4103
                     /locus_tag="ACL8AS_001930"
     CDS             3765..4103
                     /locus_tag="ACL8AS_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein YjdM"
                     /protein_id="HGS1229731.1"
                     /translation="MNNLPNCPKCNSEYVYEDGALLVCPECAHEWNPAEVAEVEEGLV
                     AIDANGNKLADGDTVTLIKDLKVKGAPKDLKQGTRVKNIRIVEGDHNIDCKIDGFGAM
                     KLKSEFVRKI"
     gene            4106..4735
                     /locus_tag="ACL8AS_001931"
     CDS             4106..4735
                     /locus_tag="ACL8AS_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Pr6Pr family membrane protein"
                     /protein_id="HGS1229732.1"
                     /translation="MSKHYKLVFYSRIFLFLAAFTGVYLEITKHGGFGMLLYYTVLSN
                     LLVTIFTLYLLKVMSRVGENWQRPSLLRLKGGVTMSIMITCVIYHFLLAPIATNFYTL
                     ENFLCHYIVPIWFLADTLFFDKQGQYKIWDPAVWTILPFLYMMFALFNGLVLKLNIPN
                     AKDNPFPYFFLNVNKGWNVVFKWCLIIFVAYMVAGFIFYFIKQIKRKSS"
     gene            4975..6126
                     /locus_tag="ACL8AS_001932"
     CDS             4975..6126
                     /locus_tag="ACL8AS_001932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HGS1229733.1"
                     /translation="MKQFLERASILALSLVLITSFSISSALPAMFDYYQGYSKEQIEL
                     LVSLPSFGIMMMLLLNGFLEKIFPERLQISLGLLILSLSGTAPFWYQAYPFVFGTRLL
                     FGLGLGMINAKAISIISERYQGKRRIQMLGLRASAEVVGASLITLAVGQLLAFGWTAI
                     FLAYSAGFLVLPLYLLFVPYGKSKKEVKKRAKEASRLTREMKGLIFTLAIEAAVVVCT
                     NTAITIRIPSLMVERGLGDAQLSSFVLSIMQLIGIVAGVSFSFLISIFKEKLLLWSGI
                     TFGLGQIVIALSSSLWVVVAGSVLAGFAYSVVLTTVFQLVSERIPAKLLNQATSFAVL
                     GCSFGAFTTPFVLGAIGLLTHNGMLVFSILGGWLIVISIFVMYLLQKRA"
     gene            6439..7188
                     /gene="truA"
                     /locus_tag="ACL8AS_001933"
     CDS             6439..7188
                     /gene="truA"
                     /locus_tag="ACL8AS_001933"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HGS1229734.1"
                     /translation="MTRYKATISYDGYAFAGFQRQSHARSVQEEIEKTLTRLNKGQTI
                     TVHGAGRTDSGVHALGQVIHFDLPYQMDEEKLRFALDTQSPEDIDVISIELVADDFHC
                     RYAKHSKTYEFILDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTAS
                     GTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQ
                     IDLILEKKDRQLAGPTAAPNGLYLKEIRYEE"
     gene            7178..7951
                     /locus_tag="ACL8AS_001934"
     CDS             7178..7951
                     /locus_tag="ACL8AS_001934"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HGS1229735.1"
                     /translation="MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTAL
                     TEKGFEVFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGVPVVL
                     DPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLPEAELLSGQEIKTLEDMKTAAQK
                     LHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVIQGQNAGAGCTFASSIASH
                     LIKGDKLLPAVESSKAFVYRAIAQADQYGVRQYEANKNN"
     gene            7929..8390
                     /locus_tag="ACL8AS_001935"
     CDS             7929..8390
                     /locus_tag="ACL8AS_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HGS1229736.1"
                     /translation="MKQTKTTKIALVSLLTALSVVLGYFLKIPTPTGILTLLDAGVFF
                     AAFYFGSREGAVVGGLASFLIDLLSGYPQWMFFSLVNHGLQGFFAGFKGKSQWLGLIL
                     ATIAMVGGYALGSTLMNGWAAALPEILPNFMQNMVGMIVGFILSQSIKKIK"
     gene            complement(8419..>8619)
                     /locus_tag="ACL8AS_001936"
     CDS             complement(8419..>8619)
                     /locus_tag="ACL8AS_001936"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229737.1"
                     /translation="FHNKTPQKLDFFCLTFGGQFIISTSYTMRFSYLKDFLLNLFMLN
                     ENQTRKLAAGCSKQCFEVADGN"
BASE COUNT         2441 a         1611 c         1933 g         2634 t
ORIGIN      
        1 gatagaactg acgaagtcag taaccatacc catggcaagg cgacgttgac gtggtttgaa
       61 ttggattttc gaagagtata agcattttac tgaaatttta tcaggtagtt taggatggca
      121 aatgacattc cctgtcaaaa atggtaaaat aagaaaaaat aatctgagaa tcgaggaaaa
      181 aagatgcaag aaaagatttt ggtaactggt ggtgccggtt ttattggaac ccacactgtt
      241 attgaattga tccaagcagg ccatcaagtt gttgtggtgg ataatcttgt caatagcaat
      301 cgtaagagtt tagaagttgt tgaaagaatc acaggagttg agattccttt ctatgaggca
      361 gatattcgtg acacagatac cctcagagat attttcaagc aggaagaacc gactggtatc
      421 attcactttg ctggtttgaa ggctgttggc gaatcaacac gtatccctct tgcctactat
      481 gacaacaata tcgctggaac tgtcagcctt ttgaaagcca tggaagaaaa caactgtaaa
      541 aacatcatct tcagttcttc tgcgacagtt tacggggatc cgcacacagt gcccatcttg
      601 gaagatttcc cactttcagt gaccaaccca tacggtcgta ctaagctcat gctagaggaa
      661 attttgaccg atatttacaa agcagactca gaatggaatg ttgtcttgct tcgttacttt
      721 aacccaatcg gagcccatga gagtggtgat ttgggagaaa atccaaacgg tattccaaac
      781 aatctcttgc catatgtgac tcaagtagcc gttggaaaat tagagcaagt gcaagtgttt
      841 ggagacgatt acgatacgga agatggaaca ggtgttcgtg actatatcca cgttgtcgat
      901 ttggctaagg gtcacgttgc agctttgaaa aaaatccaaa aaggttcagg actaaacgtt
      961 tataaccttg gaactggtaa aggttactca gttcttgaaa ttatccaaaa catggaaaaa
     1021 gcggtgggac gtcctattcc ttaccgcatc gtagaacgtc gcccaggtga tatcgctgcc
     1081 tgctactcag acccagcaaa agctaaagca gaactcggtt gggaagcaga actcgacatc
     1141 acccaaatgt gtgaagacgc atggcgttgg caaagcaagc atccaaatgg atttgaagac
     1201 taagatgatg atttcaatca tcgtcccttg tttaaacgaa gaggaagtac ttcctctttt
     1261 ttatcaggct ctggaagctt tacttccaga tttggaaaca gaaatcgagt atgtctttgt
     1321 cgatgatgga tcaagtgatg ggaccttgga actcttaaag gcctatcggg agcaaaatcc
     1381 ggcagtccat tatatttctt tctctcgaaa ttttggcaaa gaagcagccc tttatgcagg
     1441 cttgcaatat gcgacaggag atttggtggt ggtgatggat gcagacctcc aagatcctcc
     1501 tagtatgttg tttgagatga aaaatgtact agacaaaaat gtagacttgg actgcgttgg
     1561 gacacggaga actagtcggg agggagaacc cttctttcgc agtttctgtg ctgttctctt
     1621 ttatcgcctc atgcaaaaaa tcagcccagt agctctgccg tcgggtgtcc gtgattttcg
     1681 tatgatgaga aggtctgtag tcgatgccat tttaagcttg accgagtcca atcgtttttc
     1741 aaaggggctc ttcgcctggg tgggtttcaa aacctactat ttggactatc caaatgtcga
     1801 aaggcaggct ggcaagacaa gttggagttt taggcaactc tttttctact ccattgaagg
     1861 gattattaat ttttcagatt ttcccttgat tatagccttt gtagctggtc tcctatcttg
     1921 ttttctttct ctgctgatga ccttttttgt tgtggttcgg accctcattt tgggcaatcc
     1981 gacatctggt tggacctctc tgatggctgt tattctcttt cttggaggca ttcaactctt
     2041 gaccattggg attctcggca agtatatcag taagatttat ttagagacta aaaaaagacc
     2101 actttatctt atcaaagaaa aaagtgacct tcctgatttt acagaaaaaa ataaagtgaa
     2161 aagactataa ttttacatgg aaatgtgcta aactagaggg agtggattat cgccattgat
     2221 ttaggcttcc tggtttccaa tcagggcgcg agttgggcaa tttttaacag cctctaagac
     2281 atcctgacta ggagaaattt ctttttccag ttggtcaggg tcatcgtaaa aacgcacgat
     2341 tccattatcg tggtaatcaa ataaatcaga ataagtttgg caaagcccac aggcgataca
     2401 tcgttcaggt ataagtgtga ttttcatgtt catatttata ttgtaataag aaaagtaaaa
     2461 aaaaacaagg agtaaggtat ggcaaaagaa ccgtggcaag aagatatcta tgatcaagaa
     2521 gaatcaagag cagagcgtcg gcatcgaaac cacggagggg ctgataggat ggctaatcgt
     2581 attttgacga tcctagctag tattttcttt gtaattgtgg tggtgatggt catcgttctc
     2641 atctatctat catcgggggg gagtaatcgc acagcagcct taaaagactt tcatgattct
     2701 gatgcaagtg tagtacaaat ctcatcttca agcagttctc agcctgagca gagttcagag
     2761 ccagaatcta cttctagtag ttcagaagaa gctgctaatc ctgaaggaac gattaaagtt
     2821 ctcgcaggag aaggggaagc agctattgcc gctcgtgcag gaatctccat tgctcagtta
     2881 gaggccttga atcctgggca catggctaca ggatcttggt ttgctaatcc aggtgatgtt
     2941 ataaaaataa aataggagcc gatatgaaaa caattcaaat tgctattgat ggtcctgctt
     3001 ccagcggtaa gagtacggtc gcaaagatta ttgctaagga ttttggattc acctaccttg
     3061 atacaggagc tatgtatcgt gcagcgacct atatggctct taagaaccaa ttagtagttg
     3121 aagaagtcga agcccttcta gccttgttgg accagcatcc aatcagcttt ggacgttcag
     3181 aaactggaga ccagcttgtt tttgtaggag atgtggatat tacccatcct atccgtgaaa
     3241 atgaagtgac caatcatgtt tctgctattg cagcaattcc tgaagtgcgt gagaaactgg
     3301 tttctctcca acaagaaatt gcccagcaag gcggaattgt catggatggt cgcgatattg
     3361 gaactgttgt attgccacaa gcagaattga aaattttcct agtagcttct gttgatgaga
     3421 gagcagagcg tcgttacaag gaaaatattg ccaagggaat tgaaacagac cttgaaaccc
     3481 taaaaaagga aattgctgcg cgtgactaca aggatagtca tcgtgagact tctcctctca
     3541 aacaagcaga ggatgctgtc taccttgata caactggttt gaacattcaa gaagtagttg
     3601 aaaaaatcaa agcagaagct gaaaaaagaa tgtaaatgta gaaaagccga tagattgata
     3661 tcggtttttt ctaaatttgt caaaatgctg attttagggt ataatagttg ctgttcgaga
     3721 aattttgatt ttcaaagaat agtgaatgat gataaggaga aatcatgaac aatttaccaa
     3781 attgtccaaa atgtaactca gagtatgtct acgaagacgg tgccctactg gtttgcccag
     3841 agtgtgctca tgagtggaat cctgctgaag ttgcagaagt agaagaaggt cttgtcgcta
     3901 tcgatgccaa cggaaataaa ttggctgatg gtgatacagt aactctcatc aaggacttga
     3961 aagtaaaagg tgcgccaaaa gatttgaaac aagggacgcg cgtgaaaaat atccgcatcg
     4021 tagaaggcga ccacaatatc gactgtaaga ttgatggttt tggtgccatg aaacttaaat
     4081 cagagtttgt gaggaagatt taagcatgtc aaaacactat aaacttgtat tttatagccg
     4141 tatcttcttg tttctagcgg cttttacggg agtttatctt gaaattacta agcatggtgg
     4201 ttttgggatg cttctctatt acacggttct gtccaacctc ttggtaacta tttttaccct
     4261 ttatcttcta aaggttatga gccgtgtagg tgaaaattgg caaagaccaa gtctcttgcg
     4321 cttaaaaggt ggggtcacca tgagtatcat gattacctgt gtgatttacc atttcctctt
     4381 ggcgcccatt gcgactaatt tctataccct agaaaatttc ctttgccact atatcgttcc
     4441 catctggttt ttagcggata ccctcttttt tgacaaacag ggtcaataca agatttggga
     4501 tccagcagtg tggaccattt taccctttct gtatatgatg tttgctcttt ttaatggctt
     4561 ggttctaaaa ctcaatattc caaatgccaa ggataatcct ttcccttact tctttttgaa
     4621 tgtgaacaag ggttggaatg ttgtgtttaa gtggtgtctg attatctttg ttgcctatat
     4681 ggtagcagga tttattttct actttatcaa gcaaatcaag agaaagtcat cctaatactc
     4741 ttcgaaaatc tcttcaaacc acgtcagttt ccatctgcaa cctcaaaaca ctgttttgaa
     4801 caacctgcgg ctagcttcct agtttgctct ttgattttca ttgagtataa gatacaaggg
     4861 attcattttc gaatttaaga aggagtctac aaaccaatga ggcttcttct tttcttgctt
     4921 atttgataac tatcaaaaaa gtagaagatt aagagaaata tagaaagaga tttcatgaaa
     4981 caatttttag aacgggccag cattttggct ctctccctcg ttttgattac ctccttttcc
     5041 atttcgagtg ctctaccagc catgtttgac tattatcagg gttattctaa ggaacaaatt
     5101 gagctcttgg tgagcttgcc ttcctttgga atcatgatga tgttactgct aaatggtttc
     5161 ttagaaaaaa tatttcctga gcgcttacag attagtttgg gcttgctgat tttatcattg
     5221 agcggtacag ctcccttctg gtaccaagcc tatccctttg tctttggaac acggcttctc
     5281 tttggtttgg gtcttgggat gatcaatgcc aaggccattt ctattatcag tgaacgctac
     5341 caaggaaaaa ggcgaattca gatgttaggg ctacgcgctt ctgcagaggt cgttggagct
     5401 tctctcatta ccttggccgt cggtcagttg ttggcctttg gttggacagc tatctttcta
     5461 gcctatagtg ctggattttt ggtgctgccc ctttatctgc tctttgtccc ttatggaaaa
     5521 tcaaagaaag aagtcaagaa aagagcgaag gaagcaagtc gtttaactcg agaaatgaaa
     5581 ggcttgattt ttaccttagc tatcgaagcg gcagttgtag tttgtaccaa tacagctatt
     5641 accatccgta ttccaagttt gatggtggaa agaggattgg gggatgccca gttatctagt
     5701 tttgttctta gtatcatgca gttgatcggg attgtggctg gggtgagttt ttctttcttg
     5761 atttctatct ttaaagagaa actgctcctc tggtctggta ttacctttgg cttggggcaa
     5821 attgtgattg ccttgtcttc atccttgtgg gtggtagtag caggaagtgt tctggctgga
     5881 tttgcctata gtgtagtctt gacgacggtc tttcaacttg tctctgaacg aattccagct
     5941 aaactcctca atcaagcaac ttcatttgct gtattaggct gtagtttcgg agcctttacg
     6001 accccatttg ttctaggtgc aattggctta ctaactcaca atgggatgtt ggtctttagt
     6061 atcttaggag gttggttgat tgtaatctct atctttgtca tgtacctact tcagaagaga
     6121 gcttaggatt gattcctaag tttttctttt gatactcaat gaaaatcaaa gagcatagtt
     6181 gattgagttt ggaatagtac gctgtagttg ctaaaatatt tctagaaatt aatttgactt
     6241 ttctaataga gttattcata tcttatttca atctactata gaaagctagc cgcaggttgc
     6301 tcaaaatagt gttttgaggt tgcagatgga aactgacgtg gtttgaagag attttcgaag
     6361 agtatgagat ttttataccc atacaatatt tgttttaggt ccttgtttac agactaattt
     6421 cttgataaaa tagaggttat gacgagatat aaagcaacta tttcctatga tggttatgcc
     6481 tttgctggct ttcagcgcca gtctcatgcg cgtagcgttc aggaagaaat tgaaaaaacc
     6541 ttgaccagat taaataaagg gcaaaccatt actgttcacg gtgctggtag gacagatagt
     6601 ggggttcatg ccctgggaca ggtcattcat tttgacctgc cttatcagat ggatgaggag
     6661 aaactccgtt ttgccttgga tacccagtct cctgaagata ttgatgtgat ttcgattgag
     6721 cttgtggcag atgattttca ttgccgttat gccaaacata gcaagaccta tgagtttatt
     6781 ttggatagag gacgtcccaa aaatcctatg cgccgtcact atgccaccca ctttccctac
     6841 ccactcgatg tggaacgaat gcagattgca atcaaaaagc tagagggaac ccatgatttt
     6901 accggtttta cagcctctgg gactagtgta gaggataagg ttcgcaccat cacagaagct
     6961 agtttaatag tcgatgagac aggacaattt ttgaccttta ccttttcagg aaatggtttc
     7021 ttgtataaac agattcgcaa tatggtgggg actcttctca aaatcggtaa caaccgcatg
     7081 ccagtagagc agattgatct catcttggag aagaaggaca ggcaacttgc aggtcccact
     7141 gcagcaccaa atggtttgta tttaaaggag attcgttatg aagaataatc gtattttagc
     7201 actttctgga aatgatattt ttagtggtgg tggactgtca gctgatttgg ctacctatac
     7261 cttgaacggc ttgcatgggt ttgtagcagt gacttgtttg acagccttga cagaaaaagg
     7321 atttgaagtc tttccaactg atgataccat ttttcaacat gaattagata gcttgcgtga
     7381 tgtggaattt gggggaatta agattggtct tctccctact gtcagtgtgg ctgagaaggc
     7441 cttggacttt atcaaacaac gcccaggagt acctgtggtg ttggatcctg tcttggtctg
     7501 caaggaaacg catgatgtag ctgtcagtga gctctgccaa gagttgattc gctttttccc
     7561 ttatgtcagt gtgattacgc ctaatctccc agaagcagaa ttattatccg gtcaggaaat
     7621 taaaaccttg gaagacatga aaactgcagc gcagaaattg catgatttag gagcgccagc
     7681 agtcattatc aagggaggca atcgtcttag tcaggacaag gctgtggatg tcttttatga
     7741 tggacagacc tttactatcc tagaaaatcc agttatccaa ggccaaaatg ctggtgcagg
     7801 ttgtaccttt gcctctagca ttgccagtca cttgattaaa ggtgataaac ttttgccagc
     7861 agtagaaagc tctaaggctt tcgtttatcg tgctattgca caagcagatc agtatggagt
     7921 aagacaatat gaagcaaaca aaaacaacta aaatcgccct tgtatcccta ttaaccgccc
     7981 tttctgtggt tctaggttat ttcttaaaaa tcccaacacc tacaggaatt ctaactcttt
     8041 tagatgctgg tgtcttcttt gcggcctttt actttggtag tcgtgaagga gcggtagtcg
     8101 gaggactagc aagtttcttg attgacctct tatcaggcta ccctcagtgg atgttcttta
     8161 gcttggtcaa ccatggcttg cagggatttt tcgcaggatt taaaggaaaa agtcagtggt
     8221 taggccttat tttagcaact attgccatgg taggaggcta cgccttgggt tctactttga
     8281 tgaatggctg ggcagcagcc ctcccagaaa ttctaccaaa tttcatgcaa aatatggtag
     8341 ggatgattgt aggatttatt cttagtcaaa gtatcaagaa gattaagtaa tactcttcga
     8401 aaatctcttc aaaccacgtc agtttccatc tgcaacctca aaacactgtt ttgagcagcc
     8461 tgcggctagc tttctagtct gattttcatt gagcataaag aggttgagta aaaagtcttt
     8521 caaataagaa aaacgcatag tataggatgt tgaaatgatg aactgccccc caaaagttag
     8581 acagaaaaaa tctaactttt ggggtgtttt attatgaaa
//
LOCUS       DBERMM010000061         8448 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.063, whole genome shotgun sequence.
ACCESSION   DBERMM010000061 DBERMM010000000
VERSION     DBERMM010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8448)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8448)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8448
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.063"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(84..1280)
                     /gene="pgk"
                     /locus_tag="ACL8AS_001937"
     CDS             complement(84..1280)
                     /gene="pgk"
                     /locus_tag="ACL8AS_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004618 - phosphoglycerate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HGS1229738.1"
                     /translation="MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTI
                     KYIIEQGGRAILFSHLGRVKEEADKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEA
                     AINVLEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
                     SNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEK
                     ADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAF
                     AGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAG
                     TIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGL
                     AALTEK"
     gene            complement(1370..6349)
                     /locus_tag="ACL8AS_001938"
                     /pseudo
     CDS             complement(1370..6349)
                     /locus_tag="ACL8AS_001938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000795197.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="bacterial Ig-like domain-containing protein"
     gene            6642..8273
                     /locus_tag="ACL8AS_001939"
     CDS             6642..8273
                     /locus_tag="ACL8AS_001939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0005436 - sodium:phosphate symporter
                     activity [Evidence IEA];
                     GO_process: GO:0044341 - sodium-dependent phosphate
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HGS1229739.1"
                     /translation="MSINWQEILFHFLGGLGLFLYSIKTMGDGLQQAAGDRLRFYIDK
                     YTSNPFFGVLVGIGMTALIQSSSGVTVITVGLVSAGLLTLRQAIGIVMGANIGTTVTS
                     FLIGFKLGNYALPMLFIGAVCLFFTKNRTVNNIGRILFGVGGIFFALNLMSGAMAPLK
                     DLQVFKDYMIELSKNPVLGVFVGTGLTLLIQASSATIGILQNLYAGDLIDLQGALPVL
                     FGDNIGTTITAIIASLGANIAAKRVAGAHVAFNVIGTVVCVIFLVPFTVLIHWFEATL
                     NLAPEMTIAFAHGTFNITNTIIQFPFIGALAYFVTKIIPGEDEVVKYEPLYLDEHFIK
                     QAPSIALGNAKKELLHLGNYAAKAFDLSYKYIIDLDEKVAEKGHKTEEAINTIDEQLT
                     RYLIALSSEALSQKESEVLTNILDSSRDLERIGDHTEALLNLTDYLQRKNVEFSDAAL
                     KELEEVYRQTSDFIKDALDSVENNDIEKARSLVERHEAINKIERVLRKTHIKRLNKGE
                     CSTQAGVNFIDIISHYTRVSDHAMNLAEKVFAEQI"
BASE COUNT         2265 a         1864 c         1582 g         2737 t
ORIGIN      
        1 atagttgaga ggaagcgttt ttattttaag caaaagaaaa gaggaacttt catccctctc
       61 ttctttgatt tgtttataaa atcttatttt tctgtcaagg ctgcaagtcc tggaagaacc
      121 ttaccttcaa gaagttccat tgatgctcca ccacccgtac taatccatga gaacttgtct
      181 gcacggccaa ggttaatcgc tgcggcagct gagtcaccac caccgatgat tgatttaact
      241 cctggttgtt tcacgatagc gtccatcaca ccgattgtac cagcttggaa atctgggttt
      301 tcaaatacac ccataggtcc gttccataca actgttttgg caccagtcaa agcttcgtca
      361 aatttggcga tagattttgg accgatgtca agaccaagga agccttcaga aactgcttca
      421 ccttcagtgt cacgcacttc agtgtaacca gcaaatgcgt tagcttcttt tgagtcaact
      481 ggcaagatca atttaccatt tgctttttca agaagagctt tcgcaacatc caatttgtct
      541 tcttctacaa gtgagttacc gatttcgata ccttgtgctt tgtagaatgt gtaagtcatc
      601 ccaccaccga taaggacttt atcagctttt tcaagcaagt tttcgataac accgatcttg
      661 tctgaaactt ttgaaccacc aaggatagcc acgaatggac gttctggagt ttcaactgct
      721 tcttggatat aggcaatttc gttttcaaga aggaaaccag caactgcttt ttcaacgttt
      781 gctgagatac caacgttaga tgcgtgtgca cggtgagctg taccgaatgc atcgtttacg
      841 aagataccat ctccaagtga tgcccagtat ttaccaagtt caggatcgtt tttagattct
      901 ttcttgccgt caacatcttc gtaacgagtg ttttcaacca agagaacttg tccatcttca
      961 agaacgttga ttgccgcttc caattcagca ccacgagtga cacctgggaa aacaacatct
     1021 tgaccaagtt ttgctgccaa gtcagctgct acaggagcaa gtgatttacc agctttatca
     1081 gcttcttctt tcacacgtcc aaggtgagag aaaagaattg cacgtccacc ttgttcgatg
     1141 atgtacttaa tagttggaag agctgctgtg atacggttat cgttagtgat tacgccatct
     1201 ttcaatggta cgttgaagtc aacacgaacg aggacttttt tacctttcaa gtcaacgtct
     1261 ttaacagtaa gttttgccat gttacaaaaa ctcctttatt tattttattc gaaactatta
     1321 tatcacactt tggaaatata aggaaagatt tcacaagatt tttcgatatt taatctttat
     1381 cttctctttt ccgtctcaag gtcaaggcta aactagcaag accaaggctg gctaagcctg
     1441 ctattagggc ttcattagca tcagctgttc ctgtatttgg caattgtttg cttgcttctt
     1501 ctgatttaac tgctgtattt tgagctggtt tttcctgtgt agctactact gctggtactg
     1561 tttttacttt tgttccaatt tcaacaattt ctggaatcgc ttcttggatg acttctgttg
     1621 aacgaagacg acgctgaccg ttttcatcaa cttcaaagac atgtcttaac agtccatctc
     1681 gtccctgtat gatgactcgt tgttccccaa ctagcatctc agcattttca tgctcttgac
     1741 gatgaaaggc aaccttttcc tcttgaactt ccaatttagg agccttttgt tgatcagaag
     1801 ccggttgata agtaggtttt ggaaggactg tgttttgtgg tgctggttta gcaggttgtg
     1861 gtttttcagc agattcataa acaaaggcat aatgagtaaa gtgaggtgct gtaaagataa
     1921 catgactatc cgtttgttca aaagccaatt ctactgcctc tttgccttca ggtaagaaaa
     1981 atactttctt aactttctta tctttttcaa ttgggatttt cacaatagaa gcgtaagaga
     2041 gatcaacatc ttgacctttt tcatccaaac cttctatttc aaagacatga gcatcttctc
     2101 cagcaaagta tttcttctct tcagcacttg cttgaacacg ctctactttc aaacccttga
     2161 tgacagtctt ctctttattt gagaagtgta cttcaacacc tgttttacta tcagaaaaga
     2221 ctgctggctt gtcttctttc aataaagcaa ccagatcttt tagactctgt ttcgctgttg
     2281 taagctcttc tggactcaaa tctacttttt caaccaaggc cttgtttttc tcaagaagcg
     2341 gagctagggc agaacctgaa ggatggtttg gtttggcagc caagagttct tgaacctcac
     2401 ctgttaagcg atcaagttct gtcttttctt ccttaaattt ctcttgacca ttcagagctt
     2461 tatgagcctc tgtcaattta ttaagtcggt cattgacttg atcttgggtg ctagtttcat
     2521 ggtctttcaa cacttgttcg gccgcttcaa ttgctttcaa gaaagcttct tttacttctg
     2581 gtgaagcaaa gttatagacc accttgttct tagcagcttc aacttctgct aatttttgtt
     2641 tgaggtactc atcgttcaat gctgcttttg gagataccaa aacatcaaag ctaacttcat
     2701 ggccttggta atgaagcgtc aaggtttgac gaccagtctt ttgagcatcg taaccagaaa
     2761 tttcaactcc ctcatcagta aaggaatgtt attccatggt gtcattgcta taagccactg
     2821 caaagcgtcc ttcagacaag tctaagctat caccaactag gtaatctttt ttcggttcct
     2881 gacttacttc aattcccaaa atagttttcg gacttgcttc gtctttgcca gtgacagtca
     2941 ctgacaaatt agcatttacc ggttgtccca aatattggag agtaagattc tgttctccct
     3001 tatgatgcgt atcaaaacct gatactgata cacctgcgtg agttaggcga atgagttcgt
     3061 cctcagttcc tccttcatac tgaactcgaa gaacaccacc tctaaggtcc aaatcctccc
     3121 cttcggcgta gcttgttttc ttaggtcctg tttctaggct gactgacttg attcttctgt
     3181 catcttttgg aacggaaact gctaggacat tactaatttc cttgcctggc aactgggtac
     3241 gataataaag aagaccagat tgatttgtca aatccaatgg tgcacttgct aggtctcctc
     3301 caacttcgct cttcaaggtt gcaagcggag tttgagaatt tggattatca taaacagtaa
     3361 tagttgctcc agccggtaca tctgaaaagc caacttgtac cttgttattg cctagagaac
     3421 gggctgcagc cttggccatc ggaatattga cactctcagt atcaagcttt tcatacattt
     3481 tccagttata gatacgaata gccttccatg gagttccatt gtcagaagtg acaacattca
     3541 agcgccagtc ttgagcagtg attggtttat caagagtgat atctgtcacg tgtgctttgt
     3601 tgccacggac ttccttagct agcttccact caccatctgc atctttataa taaaggtcaa
     3661 agtctttggt gttcatcaag ccatcgttaa cagactcacc accagcccct gcatgatcca
     3721 tgacccatct aacaacggta cgtggcttgg tcaaacgaat atccacacta ccactcaact
     3781 gagctgaaga ccatttatct gacaagctag taatggtacc gttcaacata ccttcaatac
     3841 cttctccacc ttcagtctta gggaaagtac tatcaataac tgttgcacct ggaacgatat
     3901 tttcagctag tggttttggt aggctggtat cttttacagt cataccccaa tcaaaggttg
     3961 tggttgcagc ttctgaacga actccatttt taccgactgc tacaaccttc agttcttgag
     4021 ttgtaccctg agcacttgct gagcggctaa cttttggtag ataaatagtt gtagaagatg
     4081 agccagttag taatttccag ctgtctccat ctttttcata aacttcatag aaatctgcat
     4141 ccttgttgcc tttaaattgc acaactgctt ccgcttcttg ggcattttta agagattgtt
     4201 tcactacaga aaagcttgtc ggcgattgtg gctcttggtg attgtccgag atagttaatt
     4261 gtccgaggtt gaactgataa tcttttacag caccttcatg ctcgaaaaat agtttaactg
     4321 catagatggt tttacctgct agtgagctga gatcaaattc ttcatttgtc cagttgtcag
     4381 aaagggttag ctctttccat gcatctgcat catcgaattt gtagtctgaa gttgtagaga
     4441 atgccatata aactttagaa ccttttcctc ccttgtgggc aacacgaagt ttggtcttct
     4501 cagttacttc taacttagta gaataaagtc tcacatcctg aactgtctta ccggctacat
     4561 caccagagaa tttaagggaa tttccgccat tataggcatc tgtaaaatca tattctgcac
     4621 gaagtttttc ccctgttgaa gtctgccacc agcgccatgt tggaagaaca cctgatactg
     4681 aacgataatt ccactcagaa tccttagaaa ccttaccatc tacgaaccat tttttaccat
     4741 gacctgtatt aaaagaagta gtaaaagtat tacctaccgc tggcgtacgg tccgcaacta
     4801 ggttagcaat accataccaa tctttgtcac ctggtttttg gccagtgggg tctccttgat
     4861 aacctgtaaa gaagatatct tcatttttat gataatcttc accagttttt cctaaacttg
     4921 taatggtatc tggggcaaat aaaccaagag aaaggcgcaa tttcccattt tcgtctaaaa
     4981 tgtcattcca cttaaccttt gtcttgtagg aaccaccctg ttgcaattcc aaacctgcaa
     5041 atacatcata aggattacga ccaatccagt tggcagttgc aatagtgtaa tcatttttag
     5101 ccttatccca gttaaagtta gcaaagaagt tatctgccgg aaccttatct ccttctggtt
     5161 gcatgaattg gtagttgtat tctcccaaac catcttgatg gtaacgtcca tagttatagg
     5221 tcatggcatc ataccaagaa tacttgattg gatggtttac cttagcagca tattccttgc
     5281 tatagagcat aaactggcgc atcttttctc caagaggttt aaccaaatct ccagttgttt
     5341 cttggttgat gaaatagcca tcatagccat aatacttggc catgtctacc aatttacggg
     5401 caattgggaa gctaccatct gcgtcttgct tcaaagcttc agcaaatctt tcttgatctg
     5461 caatactatt agaccagttg aagaagagtg taccgtatac aggaaccccg ttacggtgac
     5521 ctgcatcaat aacgtcagga gttggtacga gaccttccca gaagaccatt gaatctagat
     5581 attgccaata gtcaaaagca taggccttga actcttctcc accaacagaa gcatggtctt
     5641 ttgctttaga attggtgttt gataaggctt gaacttttgc ttccttgcta gctttttcat
     5701 tgactaaatg acctgtccga cgtgaagcga ggacaacaga tccgcggtta atagcatcat
     5761 cttcacgagc acctggttcc cattttaaca attcttccca agaattaaat ttgatttcct
     5821 ttggttttaa tgttttttct gtatttttag ggacatctgg ctggacttct ttttcagtct
     5881 tattagcttc tgctgctggt ttagactcat ccccttggtt agttgcttcg ggctttgctt
     5941 ctgtttcctt gtcagactta ggttttgctt ctgcagatgg tgtttctgca accacctcac
     6001 ttgctttttc ctctggttta gctgcgctag ctgcttctgc agtttcagta gttgcagctt
     6061 cattgcttgc tggcgaagca gtttcagatg ctgtcgctac tccttctgcc ttttctagct
     6121 tgttttctct agcatgttcc ccttcattct gcttatcagc ttcattggtc gaatgctcac
     6181 tctctcctga aacaagctct gtattagctc cgctattttc aggaactgca gtttcttcag
     6241 ccaaggctgg accagcaaat aaaacagcac caatcatcag cgagcaggct cctactgata
     6301 acttacgaat actgtaacga caacgtcttt caaaaaatgg attcttcatt ttctcctcct
     6361 aaaagattga ttttgttgtt ttaaagaaag cgctttatat tctgtagttt tttatcaaac
     6421 tctagaacca tgataatcac atttttatcc taaaacattt ttagacaaaa aacaataact
     6481 gtttgcacaa atctaaaata aggttaaaaa ctcttaaaaa taatacactt atcaattata
     6541 attttctttt acaaacttga cattaacact tgttagattt acttttatcc tttaaaatag
     6601 aataggagat attccgcgat tatttttcgg aggaaaaaga aatgtccatt aattggcaag
     6661 aaattttatt tcacttttta ggtggtctgg ggctattctt atatagcatc aagaccatgg
     6721 gagacggttt gcaacaagct gctggagatc gccttcgttt ttacattgac aaatatacta
     6781 gtaatccttt ctttggagtt ctggttggta ttgggatgac tgctctaatt cagtctagtt
     6841 ctggtgtaac agttattaca gtcggcctgg tcagtgccgg tctcttaacc ttacgtcagg
     6901 ctatcgggat tgtcatgggt gctaatattg ggacaactgt cacatccttt ctcatcggtt
     6961 ttaaattagg taactatgcc ctacctatgc tctttatcgg tgccgtctgt ctctttttta
     7021 cgaaaaatcg gacagtcaat aatatcggac gcatcctctt tggtgtcggt ggtatctttt
     7081 ttgccctcaa tctcatgagc ggcgcaatgg ctccactcaa ggatttacag gtctttaagg
     7141 actatatgat tgagctaagt aagaatcctg ttctgggtgt ctttgtcggt actggcttga
     7201 ccttgctaat tcaagcttct tcggctacca ttgggatttt acaaaacctc tacgccggcg
     7261 atctaattga cctacaggga gctttgccag ttctatttgg tgacaatatc gggacaacca
     7321 ttacagccat cattgcctct ttaggggcta atattgcagc taaacgggta gcaggagctc
     7381 atgttgcctt caacgttatc ggaacagtcg tctgcgttat ttttctagtt ccttttactg
     7441 tcctgattca ttggtttgaa gctacgctaa atctagcacc ggaaatgacc atcgcctttg
     7501 ctcacggaac ctttaatatt accaacacca ttatccaatt tccatttatc ggagctctgg
     7561 cttactttgt aaccaagatt attcctggag aggacgaggt tgtcaaatac gaacccttat
     7621 atcttgatga acatttcatc aaacaagccc catctatcgc tctaggaaat gccaaaaaag
     7681 agctcttgca cttaggaaac tacgctgcta aagcctttga cctttcctat aagtacatca
     7741 ttgacttgga tgaaaaagtt gctgaaaaag ggcataaaac cgaagaagca attaacacca
     7801 tcgatgagca attaacacgt tatctcattg ccctttcaag cgaagctctc agccaaaaag
     7861 aaagtgaagt gcttaccaat atccttgatt cctcccgtga tttggaacgg attggagacc
     7921 acacggaggc tctactcaat ctgactgact atcttcaacg gaaaaatgtt gaattttctg
     7981 atgccgcctt gaaagaatta gaggaagttt accgccaaac tagtgacttt atcaaagatg
     8041 ctctggatag tgtggaaaac aatgatattg aaaaagcacg cagtcttgta gaacgtcatg
     8101 aagcaatcaa taagatagaa cgtgttctca gaaaaaccca catcaaacgc ctcaacaaag
     8161 gcgaatgttc aacacaagct ggggtcaact ttatcgacat catctcacac tacactcgtg
     8221 tatcagacca cgctatgaac cttgctgaaa aggtttttgc agaacaaatc taataaccaa
     8281 gaagctatcc atcataattg gatggcttct tactttttcc taagcaagac taggctgaat
     8341 gaaactgaaa gagtattctg cagatatata gtatattgaa actagaatag tacacctcta
     8401 tttctaaaac attgttagaa atcgatttga ctgtcctgat cgatttgt
//
LOCUS       DBERMM010000062         7718 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.064, whole genome shotgun sequence.
ACCESSION   DBERMM010000062 DBERMM010000000
VERSION     DBERMM010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7718)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7718)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7718
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.064"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..218)
                     /locus_tag="ACL8AS_001940"
     CDS             complement(<1..218)
                     /locus_tag="ACL8AS_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_152639374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HGS1229740.1"
                     /translation="MAYSIDFRKKVLSYCERTGSIAEASHVFQISRNTIYGWLKLKEK
                     TGELNHQVKGTKSRKVDRDRLKNYLTDNP"
     gene            389..544
                     /locus_tag="ACL8AS_001941"
                     /pseudo
     CDS             389..544
                     /locus_tag="ACL8AS_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
     gene            744..4019
                     /gene="rexB"
                     /locus_tag="ACL8AS_001942"
     CDS             744..4019
                     /gene="rexB"
                     /locus_tag="ACL8AS_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA];
                     GO_process: GO:0000724 - double-strand break repair via
                     homologous recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="HGS1229741.1"
                     /translation="MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKER
                     AVLECLSQQASFSITVTRFAQMARYLVLNDLPVKTTLDDIGLGLAFYKCLAELDPKDL
                     RVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRTDLLLIFEKVTAYLNQ
                     GQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVI
                     GAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLE
                     SSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILL
                     GDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLL
                     RTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQIFTKSHHGKFNLERLNVLRLRILAP
                     LETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVL
                     EQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYA
                     IGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSA
                     RKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSL
                     VAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDLQGLENPAIPTSPSSKTLAKDTLQALY
                     PAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQL
                     PNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIE
                     TIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPH
                     FFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKY
                     QGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYT
                     ENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWFEKIREE
                     LNR"
     gene            4016..7666
                     /gene="addA"
                     /locus_tag="ACL8AS_001943"
     CDS             4016..7666
                     /gene="addA"
                     /locus_tag="ACL8AS_001943"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0016818 - hydrolase activity, acting on
                     acid anhydrides, in phosphorus-containing anhydrides
                     [Evidence IEA];
                     GO_process: GO:0000724 - double-strand break repair via
                     homologous recombination [Evidence IEA];
                     GO_process: GO:0006302 - double-strand break repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HGS1229742.1"
                     /translation="MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNIL
                     VSASAGSGKTFVMVERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQET
                     DDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLE
                     NEVFHEVFEAHYQGKQKESFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWL
                     SESFLKGFEKADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLI
                     LDEIGSLNQEFDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQ
                     FTKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADIS
                     HYTIEILENFPQVRESYQERFHEVMVDEYQDINHIQERMLELLSNGHNRFMVGDIKQS
                     IYRFRQADPQIFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVG
                     EINYDNMHQLVFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEI
                     LKLHQEKGVAFKEIALLTSSRNRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLD
                     TLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKAHENLYEKLVNAQKKAS
                     SQKGLIHTALAEKLKQFMDILASWRLYAKPHSLYDLIWKIYNDRFYYDYVGALPNGPA
                     RQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIH
                     KSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIK
                     LSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLESKEYPAAK
                     NGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLQ
                     DSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGV
                     EIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLK
                     QVQTSQAVRDKINLDKILAFFDTALGQEIFANTDHLYREQPFSMLKRDQKSQEDFVVR
                     GILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLI
                     LLGKDEVQVVKV"
BASE COUNT         2341 a         1611 c         1626 g         2140 t
ORIGIN      
        1 ggattgtcag taagatagtt tttaagtcta tctctatcaa cttttcttga ttttgttcct
       61 tttacttggt ggtttagctc tcctgttttc tcttttagct ttaaccagcc ataaatggta
      121 ttacgtgaga tttggaaaac gtgtgatgct tctgctatac tacctgttcg ctcacaataa
      181 gagagaactt ttttacgaaa atctattgaa tatgccataa gaagattata ccacattgtg
      241 tactattttt ggttcatttt actatattag attgaaataa gatacgaaca gcttgattag
      301 ggaaatcaaa ttaatttcta gaaatatttt agcatccacg atgtactatt atagtttcaa
      361 tttactatag ttcaatcatt ctatcaagaa tattgaatat ataaaggcac gtaatattaa
      421 aacttcttct gatatcgaat tagagtccga tgttgatggc gataaatcag acaatctacc
      481 cgtcgacatt aagatactgg gacaacacat tgaagtgtat tccgtaccta agaaacaatc
      541 ataaaactca aagtcttgtt accgaggctt ttttattatg tgattttcag tagccagact
      601 tattctatct aatacaagta aagctaagta tttaagattt agcagatgat gaagaaaaga
      661 aaggatggcc taaatatttt aacagattta cgaggctaat catggtataa tatagggtga
      721 tgaaaaattc caacgaggct gagatgaaat tactttatac tgatattcga acttctttga
      781 cagaaattct aacaagagag gcagaagagc tagttgcagc tggcaagcgg gtcttctaca
      841 ttgcccccaa ctctctttct tttgaaaagg aacgcgccgt gctggaatgc ttgtcccagc
      901 aggcttcttt ttctattacc gtcacgcgct ttgctcaaat ggctcgttat ctggtcctga
      961 atgatttacc agttaaaact actcttgatg atatcggtct tgggttggcc ttttacaaat
     1021 gccttgccga actcgatccc aaggacttgc gtgtttatgg cgctattaag caggatcctc
     1081 aattgatcca gcagttaatt gagctttacc atgagatgac caaatctcag atgagttttt
     1141 tggacttgga gaatttaaca gatgaggata agaggacgga tttactcttg atttttgaga
     1201 aagtaacagc ctatcttaat caaggtcagt tagcccaggg aagtcagttg tcccatttga
     1261 ttgaggctat tgagaatgac aaggtaagta gtgattttaa tcaaatcacc ttggtcattg
     1321 acggctttac tcgtttttct gctgaggaag agcgggttgt ggacttactt cacggcaaag
     1381 gtgttgagat tgttatcggg gcttatgcta gtaagaaagc ctataccagt ccttttagcg
     1441 agggcaatct ctaccaagcc agcgtaaaat ttctccatca tctggcttct aaataccaaa
     1501 cgcctgctca ggactgttct caaactcatg agaagatgga tagttttgac aaggcttctc
     1561 gtttgttgga gtcttcttat gacttttcag aactcgcttt ggatgtcgat gagaaagacc
     1621 gtgaaaattt acaaatctgg tcttgtttga cgcaaaagga ggagttggag ctagtagccc
     1681 gtagcattcg tcagaaatta catgagaact cagacctgag ctacaagcat tttcgtattc
     1741 tcttggggga tgtagcttct taccagttat ctctcaaaac catttttgac cagtatcaga
     1801 ttccttttta tcttggtaga agcgaagcca tggctcatca tcccttgact cagtttgtcg
     1861 agtctatttt agctttaaaa cgttaccgtt ttcgtcagga ggatttgatt aatcttctta
     1921 gaactgattt gtatactgac ctcagtcagt ctgatattga tgcttttgag caatatatcc
     1981 gctatcttgg tatcaatggc ttgccagcct ttcagcaaat cttcaccaaa tcccaccatg
     2041 gaaaatttaa tcttgagcgt ttgaatgtcc tccgcctgag aattttagca cctcttgaaa
     2101 ccctctttgc cagccgaaaa caaaaggctg aaaacctcct acaaaaatgg agtgtctttc
     2161 taaaagaagg agctgtgacc aagcagttac aagatttgac aaccactttg gaagctgtag
     2221 aacaggaaag acaagccgaa gtttggaagg ctttctgcca tgttttagaa caatttgcga
     2281 ctgtttttgc tggttcacag gttagtctgg aagacttcct agccttgctc cattctggaa
     2341 tgagtttgtc ccaataccgt accattccag caacagtgga cactgttctg gtgcagagtt
     2401 acgatttgat tgcaccattg actgctgact ttgtctatgc tattggacta actcaggaca
     2461 atttaccaaa aatttctcaa aacaccagtc ttctgacaga tgaagaaagg caaaatctaa
     2521 accaagcgac cgaagaaggc gttcaattac tgattgccag cagtgaaaat ctcaagaaaa
     2581 atcgctacac tatgctttcc ttggtcaatt ctgctcgtaa gcagttgttc ttgtcggctc
     2641 caagcctttt taacgaaagt gaaagtaagg aatctgccta tcttcaagag ttgatccatt
     2701 ttggatttag gcggagagag aagaggatga atcacaaagg actgtctaag gaggatatgg
     2761 ggtcctatca cagtcttttg tctagtctgg ttgcctatca ccagcagggt gagatgagcg
     2821 atactgagca agatttgact tttgtcaagg ttctgtcgcg tgtcataggt aaaaaactag
     2881 atctgcaagg tctggaaaat ccagctatcc caaccagtcc aagcagcaag accttagcca
     2941 aggacacctt gcaagctctc tatcctgcca aacaggagtt ttacctgtct acgtcgggtt
     3001 tgacagagtt ttatcgcaat gaatacagtt atttcctacg ctacgtttta ggcttgcagg
     3061 aggaattacg tttgcgtcct gatgcccgta gtcacgggaa tttcttgcat cgtatctttg
     3121 aacgcgcctt acagttgcct aatgaagatt cctttgacca acgtctagaa caagctattc
     3181 aagaaaccag tcaagaacgc gaatttgaag ctatttatca agaaagtttg gaagcccagt
     3241 ttaccaagga agttttgctt gatgttgcac ggacgactgg acatattctc cgacacaatc
     3301 cagccatcga aaccatcaaa gaagaagcaa attttggtgg aaaagaccaa gcctttattc
     3361 aattagacaa tggacgcagt gtctttgtac gaggcaaggt ggaccggatt gaccgtttga
     3421 aagctaatgg agcgatagga gtagtagact acaaatccag tctgactcag ttccagtttc
     3481 ctcatttctt taatgggctc aattctcagt taccaaccta tcttgctgcc ctaaaaagag
     3541 aaggggagca gaactttttc ggcgccatgt acttggaaat ggctgaacct gtccaatctc
     3601 tgatggcggt aaaaagtctg gcaggagcag tggtagaagc cagcaaatct atgaaatacc
     3661 aagggctctt cttggaaaaa gaaagcagtt atttaggcga attttataac aaaaacaagg
     3721 ctaatcaact gacagatgag gaatttcagc tcctactgga ctacaatgcc tatctttaca
     3781 agaaagctgc tgagaagatt ttagcaggcc ggttcgccat caatccttat actgaaaatg
     3841 gcagaagcat tgccccatac gtccagcaac atcaggctat tacaggcttt gaagccaatt
     3901 accatctggg ccaagcccgt ttcctagaaa agttggacct agctgatggc aagcgtctgg
     3961 tcggagaaaa actcaagcaa gcttggtttg aaaaaataag agaggagtta aatcgatgaa
     4021 gcttattccc tttttaagtg aggaggagat tcaaaaactg caagaagcag aagcaaattc
     4081 gagcaaggaa cagaagaaaa ctgccgaaca aatcgaagct atctacactt ctggtcagaa
     4141 tatcctggtc tcagcatcgg ctggttctgg aaagaccttt gtcatggtag agcgcattct
     4201 ggaccaattg gcgcgtggtg tcgaaatttc tcaactcttt atctcaacct ttaccgtcaa
     4261 ggctgcaact gaacttaaag aacgtttaga gaaaaaaatc agcaagaaaa tccaagaaac
     4321 agatgatgtc gatctcaaac aacacttggg tcgccagttg gcagacctac ccaacgctgc
     4381 catcggaacc atggactctt tcacacaaaa attccttggc aaacatggtt atctgcttga
     4441 tattgcacct aatttccgta ttttacaaaa ccaaagcgag caacttcttc tcgaaaacga
     4501 agtctttcat gaggtctttg aagcgcatta ccaaggtaaa cagaaagaga gctttagtca
     4561 tttgctgaaa aactttgctg ggcgtggcaa ggacgaacgg ggtctgcggc agcaagtcta
     4621 taaaatctat gacttcctcc aatccaccag taatcctcaa aagtggctga gtgaatcttt
     4681 cctcaaaggc tttgagaaag ctgattttac cagtgaaaaa gaaaaactga ctgagcaaat
     4741 caaacaagcc ctctgggatt tggaaagctt tttccgttac catctggata acgatgccaa
     4801 ggagtttgca aaggctgcct atttagaaaa tgttcagtta attctggatg aaattggctc
     4861 cctaaatcag gagttcgata gtcaggctta tcaggcagta cttgcgcgtg ttgtcgccat
     4921 ctctaaggag aaaaacggtc gagctctgac taatgccagc cgtaaggctg atttgaagcc
     4981 cctggctgat gcctacaacg aagagagaaa gacccagttt actaaactag gacaattatc
     5041 agaccagata gcgattctcg actatcaaga acgttatcat ggagacactt ggaaactagc
     5101 taaaaccttc caatctttca tgagcgattt tgtagaggct tatcgtcaga gaaaacgaca
     5161 ggaaaatgcc tttgaattcg ctgatatcag ccattacacc attgagattt tagaaaattt
     5221 cccacaagtt cgtgagtctt atcaggagcg cttccatgaa gtcatggtcg atgagtatca
     5281 ggatatcaac catattcaag aacggatgct ggaattgttg tctaatggcc acaatcgctt
     5341 tatggtggga gatatcaagc aatccatcta tcgtttccgt caggcagacc cgcagatttt
     5401 caatgagaaa ttccaacgct atgcgcaaaa tcctcaagaa ggcaagctca ttctcctcaa
     5461 ggaaaatttc cgtagtagtt cagaagtgct gtcagcaacc aatgatgtct ttgaacgtct
     5521 catggaccaa gaggtcggcg aaatcaacta tgataacatg caccagcttg tttttgccaa
     5581 taccaaactg actcccaatc cagacaacaa ggccgaattt ctcctctacg acaaggacga
     5641 tacaggtgag gaagaagaga gtcaaacaga aacgaaacta acaggcgaaa tgcgcttagt
     5701 tatcaaggag atccttaaac ttcatcagga aaaaggtgtt gcctttaagg aaattgccct
     5761 tctgacctct agtcgtaatc gtaatgacca aattctactt gccctgtctg agtacgggat
     5821 tcctgtcaaa actgacggag agcaaaacaa ttatctccaa tccctagaag tgcaagtcat
     5881 gctagacacc cttcgtgtca ttcacaatcc cctgcaagac tacgccttgg ttgcccttat
     5941 gaagtctcca atgtttggtt ttgatgagga tgagctagca cgtttgtccc ttcagaaagc
     6001 agaggataaa gcccacgaaa atctctatga gaaactagtc aatgcacaaa aaaaggcaag
     6061 tagtcaaaaa ggcttgattc acacagctct agctgaaaaa ctaaagcaat tcatggatat
     6121 cctagcttct tggcgcttgt atgccaaacc ccactctctc tatgacttga tttggaagat
     6181 ttacaacgac cgtttttatt atgactatgt tggggctttg ccgaatggtc ctgctaggca
     6241 ggccaatctc tatgccctag cactgcgtgc tgatcaattt gaaaagagca atttcaaagg
     6301 tttgtcgcgt tttattcgta tgattgacca agtcttagaa gcccagcacg atttggcaag
     6361 cgtggccgtc gcaccgccaa aagatgcagt agagctcatg accatccaca agagtaaagg
     6421 gctggagttt ccttacgtct ttatcctcaa tatggatcaa gatttcaaca aacaagactc
     6481 tatgtcagaa gtcattctca gtcgtcagaa tggtcttggt gtcaaatata ttgccaagat
     6541 ggagacaggg gcagtagaag accactatcc taaaaccatc aaactctcca ttcctagtct
     6601 gacctatagg cagaacgaag aggaattaca gctagcaagc tattctgagc agatgcgttt
     6661 gctgtatgtt gctatgacgc gggctgagaa aaagctctat cttgtcggca agggttctcg
     6721 tgaaaagctg gaatccaagg aatacccagc agccaaaaat gggaaactaa atagcaatac
     6781 tagactgcaa gcacggaatt tccaagattg gctttgggct atcagtaaag tgtttactaa
     6841 ggacaagctc aactttagtt atcgttttat tggcgaagat cagttgacca gagaagctat
     6901 cggagagttg gaaaccaaga gtcctctcca agatagctcc caagcagaca atcgtcagtc
     6961 agataccatc aaagaagctc tggaaatgct gaaggaggtg gaagtttata atactcttca
     7021 ccgcgcagct attgaacttc ctagtgttca aaccccaagt caaatcaaga aattctacga
     7081 accagttatg gatatggaag gtgtcgagat tgctggtcaa ggtcagtcag taggcaagaa
     7141 aatcagcttc gatttgccag atttttcaac caaagaaaag gtaactggag ctgagattgg
     7201 tagtgctact cacgaactca tgcagagaat tgacctcagc cagcaactaa cccttgctag
     7261 cctaacagaa acactcaaac aagttcaaac tagccaagct gtcagagaca agatcaatct
     7321 tgataaaatt cttgctttct ttgacacagc actcggtcag gaaatttttg ctaataccga
     7381 ccatctctat cgcgagcaac ctttctccat gctcaaacga gaccaaaaga gtcaggaaga
     7441 ctttgttgtc cgtggtatcc ttgatggcta tctgctttac gaaaacaaaa ttgttttgtt
     7501 cgactacaag acagaccgct atgatgaacc aagtcaactc gtagaccgct atcgtggtca
     7561 gttagctcta tacgaagagg ctttatcacg agcctattcg attgaaaata ttgaaaaata
     7621 cttgatttta ctcggtaaag acgaggttca agttgtaaaa gtataactta tactcttcga
     7681 aaatctcttc aaaccacgtc agcttcgcct tgctgtat
//
LOCUS       DBERMM010000063         7665 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.065, whole genome shotgun sequence.
ACCESSION   DBERMM010000063 DBERMM010000000
VERSION     DBERMM010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7665)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7665)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7665
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.065"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..122
                     /locus_tag="ACL8AS_001944"
     CDS             <1..122
                     /locus_tag="ACL8AS_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
                     /protein_id="HGS1229743.1"
                     /translation="IFAKVKTFKMISTTYRNHRKRFGLRMNLIAGIINHELGF"
     gene            complement(860..1120)
                     /locus_tag="ACL8AS_001945"
     CDS             complement(860..1120)
                     /locus_tag="ACL8AS_001945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229744.1"
                     /translation="MRERSATGAQGLSKSIKKHLNDLTRLTASLLGDEKLSAITSSSA
                     VKADMHRFVIELELVKSTILQNDDISLDQNEIFEILKNFFDG"
     gene            complement(1179..1730)
                     /locus_tag="ACL8AS_001946"
     CDS             complement(1179..1730)
                     /locus_tag="ACL8AS_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001111259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229745.1"
                     /translation="MPANTKVIFQEMFADFQNYYVLIGGTATSIVLDSQGFKSRTTKD
                     YDMVIIDEVKNKEFYTTLNHFLELGEYQGSQKDEKAQLFRFTTTNLEFPSMIELFSIL
                     PEYPLKKDGREISLYFDQDASLSALLLDEDYYNILVHVKETIQGYSVLSNCGLYSSTI
                     SSNHVSFHLQPQNSVLSSLRLAS"
     gene            complement(1720..1917)
                     /locus_tag="ACL8AS_001947"
     CDS             complement(1720..1917)
                     /locus_tag="ACL8AS_001947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229746.1"
                     /translation="MLEIWKYRPFVSEFWNDFKNNHDKQFVDPISLYLTLKDDDDPRI
                     EEESEALENMILQYLGEDDAS"
     gene            complement(1921..2715)
                     /locus_tag="ACL8AS_001948"
     CDS             complement(1921..2715)
                     /locus_tag="ACL8AS_001948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229747.1"
                     /translation="MNVKKIMSIFQSFYVDVSIEELTLTLPISFVKRFEYTQMTFHKE
                     SFLLIKEKRRGSLSSFVTQARTMGEKANMDVVLVFSKLSDSEKKQLLQARVPFVDFKG
                     NLFFPPLGLVLNANDTEVPKELTPSEQLTWIAFLLTKGQKVVDVDLLSQVTGLPNSTI
                     YRCLRTFKALYWLNKQNKLYTYTVSKKELFLKSVSCLFNPIKKRILLPDGDIKQIKSV
                     SNLLYGGAYALSHSTFLAETDENTSYVIWQRKFNQLSLPLSQYVLK"
     gene            complement(3123..3548)
                     /locus_tag="ACL8AS_001949"
     CDS             complement(3123..3548)
                     /locus_tag="ACL8AS_001949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000204068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229748.1"
                     /translation="MTSRVFIDADCISVFLWVGTEHLLEKLYSGKIVIPQEVYDEINI
                     PTIPHLKSRIDQLVAKGSAEIVSIDIGTEEYALYRDLTRNHDSNKIIGKGEAASISLA
                     KKHNGILGSNNLRDVKSYVEEFSLEHMTTGDILIEAFKV"
     gene            complement(3677..4036)
                     /locus_tag="ACL8AS_001950"
     CDS             complement(3677..4036)
                     /locus_tag="ACL8AS_001950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="HGS1229749.1"
                     /translation="MKKSSVSLILIGEGDETERKADQFASYFLIFPSSLYRMVEEIRE
                     NANRTHLEVEDIIKLGQFYGISHKVMLYRLRNDGYLDAEEIKNMDISVIETASRLGYD
                     TSLYRPLSESKKEMSLG"
     gene            complement(4082..4288)
                     /locus_tag="ACL8AS_001951"
     CDS             complement(4082..4288)
                     /locus_tag="ACL8AS_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000366086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229750.1"
                     /translation="MDLSNKAPNLRKKLGADGESPIDIFKLVQKIENLTLVFYGLGKN
                     ISGVCYKGTQFSLIAVNSDMPLGR"
     gene            complement(4275..4436)
                     /locus_tag="ACL8AS_001952"
     CDS             complement(4275..4436)
                     /locus_tag="ACL8AS_001952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1229751.1"
                     /translation="MNMINVCDVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKG
                     ERNITNGFK"
     gene            complement(4782..5738)
                     /gene="lytA"
                     /locus_tag="ACL8AS_001953"
     CDS             complement(4782..5738)
                     /gene="lytA"
                     /locus_tag="ACL8AS_001953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HGS1229752.1"
                     /translation="MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWR
                     KDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
                     REQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLAD
                     RWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK"
     gene            complement(6114..7484)
                     /locus_tag="ACL8AS_001954"
     CDS             complement(6114..7484)
                     /locus_tag="ACL8AS_001954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HGS1229753.1"
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVG
                     RFLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWIL
                     GALLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLR
                     SIGDSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRK
                     SVPELLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQ
                     TAARRIMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIF
                     LFFASPALVSFLASSTDGYLIENGSLYLQISSTFYPILSLLLIYRNCLQGLGQKILPL
                     VSSFIELIGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAIL
                     ATKVQS"
BASE COUNT         2476 a         1565 c         1207 g         2417 t
ORIGIN      
        1 acatctttgc caaagtaaaa acgtttaaaa tgatttcaac aacctatcga aatcatcgta
       61 aacgctttgg attacgaatg aatttgattg ctggtattat caatcatgaa ctaggattct
      121 agttttgcag gaagtctatt atatatgcac agacatatga aatctttttg agatagcagt
      181 tatgatatat ttatccattc acaacatctt ctgtaccaat actacaatat tggtacattt
      241 tgattacaca atcgtttcaa aaaatatgat ggaagcctga gtattttata gtaactccct
      301 tcctatcaac tagatcaacc agttgagtgt tgaatgttga aacaccctag cctcagcaaa
      361 ggactatgag cagcatttcc tagccaatag gacgctccaa atcacctatt ctaaatccat
      421 cactagcttg gtcagtaaga tacagactgc aaggcaagac tgacgtggtt gatgagattt
      481 tggaagagta ttacaatcat agattcacca gtagacttga ccgcagattt aactatagta
      541 gattgaaact agaatagtac acttctgctt ctaaaacatt gttagaaatc gatttgactg
      601 tcctgatcaa tttgtcctgt tctcgtttca ttttactata ctaaaaaacc acctgaaaca
      661 aatcaagtga ctagaggata aaaacaaaaa ctgggcaaaa agttttgaaa agcaaaaaac
      721 gcataatatc aggtcttgaa aaaccttgat actatacgtt tgattgtggg aagattgact
      781 tcattttctc ctgaaattga agttttttct agtttccaga tatagacgaa ttcaatatag
      841 ccatctcgct acaattattt taaccatcga aaaaattttt cagaatttca aaaatttcat
      901 tttgatctaa tgaaatgtca tcattttgaa gaatagttga cttcacaagc tctaattcta
      961 tcacaaagcg gtgcatgtct gcttttaccg cactacttga tgttatagcc gataactttt
     1021 catctcctag caaggaagct gtcaaacggg taaggtcatt caaatgcttt ttaatggact
     1081 tacttaaacc ttgagcacct gtagcagagc gttccctcat atccagccaa gctttagcct
     1141 taaaaataat taatactcaa tgaaaatcaa agagcaaact aggaagctag ccgcaggctg
     1201 ctcaaaacac tgttttgagg ttgtagatgg aagctgacgt gatttgaaga gattgtcgaa
     1261 gagtatagac cacaattact caataccgaa tacccctgaa tggtttcttt tacatgcacc
     1321 aatatattat aataatcttc atccaataat aaggctgata aactagcatc ttggtcaaaa
     1381 tataaggaaa tttctcgacc gtccttcttt aatggatatt ctggtaagat actaaatagt
     1441 tcaatcatag aaggaaactc aagattagtt gttgtaaatc gaaaaagctg cgctttctca
     1501 tctttctgac ttccttgata ctctcccaat tctaaaaaat gattcaaggt agtataaaat
     1561 tccttatttt ttacttcatc aatgatgacc atatcataat cttttgttgt gcgactttta
     1621 aatccttgcg aatccaatac gatagaggta gcagttcccc caatcagaac ataatagttc
     1681 tgaaaatccg caaacatttc ttgaaaaata actttcgtat tagctggcat catcttctcc
     1741 cagatactgt aatatcatat tttctagtgc ttcactctct tcctctatac gtgggtcatc
     1801 atcatctttt aaggtcaaat aaagagaaat cggatctaca aattgtttat catgattatt
     1861 tttaaaatca ttccaaaact cagatacaaa aggacgatat ttccatatct ctagcatctt
     1921 tcattttaaa acatactgag aaagtggcaa ggataactga ttgaattttc tctgccatat
     1981 gacatagcta gtattttcat ccgtttcagc taaaaaagtt gaatgcgaca aagcataagc
     2041 accaccatat agaagattag aaacagattt tatctgcttt atatcgccat ctggcaataa
     2101 aatccgtttt ttgatgggat taaataaaca tgacacggat tttaagaata attctttctt
     2161 tgacaccgta tatgtgtaaa gcttattttg cttgtttaac caatataaag ctttaaaagt
     2221 cctcaaacac ctataaattg ttgagtttgg aagtccagtg acttgtgaaa gcaaatcaac
     2281 atctactact ttttgacctt ttgtcaataa aaaggcaatc cacgttaatt gttcgctagg
     2341 tgttaattcc ttagggactt cagtatcatt cgcattcagt actagtccca atggagggaa
     2401 gaagaggttt cccttaaagt ctacaaacgg aactctagct tgaagtaatt gctttttttc
     2461 actgtctgat aacttcgaaa acaccaaaac aacatccata ttggcttttt cacccatagt
     2521 gcgagcctga gtaacaaatg aactcaaact cccccttctc ttttctttaa tcaataaaaa
     2581 tgattcctta tgaaaagtca tttgagtata ctcaaacctt tttacaaaac tgattggtaa
     2641 agtcaaagtc agttcctcaa tactgacatc aacataaaag gattgaaaaa ttgacattat
     2701 ctttttgaca ttcatgtttt ttccttattc tatcattttt attatatttt atcattcggt
     2761 ataataaaat ataagttttt tgataaaata accaaaaact actcgctatc ccctctcaca
     2821 ttaccctaca tatcgtttga catgcgactg atagttcagg aaaacttcaa ggagaacttt
     2881 tctctcatcc actatgcagg acttactatt tcacttctac tcctataggc tcaatttgac
     2941 acttttcttt ttcgaattgc tcatatgcct cctgaatagt gagttcgatt tatccaaatt
     3001 tatttttgtc tattttgatg aatacttcca cgaagatagt ctgaaaatga atttgcacca
     3061 attttccttc tctttttaag catattattc cagatatgat tgccctcttg ttcagtaata
     3121 aattacactt taaacgcttc aatcagtata tctcctgttg tcatatgttc taaagaaaat
     3181 tcttctacat atgatttaac atctcttagg ttattacttc ctaatatccc attatgcttt
     3241 ttcgctaagg aaatagaagc cgcttctccc ttaccaataa tcttgttact atcatgattt
     3301 cttgttaaat ctctatataa tgcgtattct tcagttccaa tgtctatgct cacaatctca
     3361 gctgaaccct tagctaccaa ctggtctatc ctagatttta aatggggaat tgtaggtata
     3421 ttgatttcat catacacctc ttgtggaata acaattttac ccgaatagag cttttctaaa
     3481 agatgttcag tgccaaccca taaaaatact gaaatacaat ctgcatcaat aaatacacga
     3541 ctagtcaaac gacaactccc ccctcttcat ctagcccata tacaatatca tatctgaaag
     3601 catctagtaa cagttcctca tacttccctt gcgaaattct gttattttct aaaagttgtt
     3661 cagttgaatt aatatattat cctaatgaca tttccttttt actttctgac aaaggacgat
     3721 ataaacttgt atcatagcct aatcttgaag ctgtctctat aacactaata tccatatttt
     3781 taatttcttc tgcatcaagg tatccatcat tcctcaatct atataacata actttatgac
     3841 tgataccata aaactgaccc aattttataa tatcttctac ttcaagatga gttctattgg
     3901 cattttctct gatttcctca accatcctat acagtgaaga tgggaaaatt aaaaaataag
     3961 aagcaaactg atccgctttt ctttcagttt catctccttc accaatcaag ataagactga
     4021 ctgaactctt cttcacctca tcataataaa gatgatacag tccatgtgct aaagaaaatc
     4081 tttaccttcc taatggcata tctgaattga ctgcaatgag actgaactga gttcctttat
     4141 aacagactcc gctaatattc tttccgagtc cataaaatac cagcgtcaaa ttttctatct
     4201 tttgtaccaa tttaaaaata tctatcggcg attcaccatc agctcccaac ttttttctaa
     4261 gatttggagc tttattactt aaatccattc gtgatattcc tttcaccttt ttccattttg
     4321 gcaatcatgc tttgattcaa agacaaatac tcagcaatct tatcttgagt aagatttgaa
     4381 gatattctaa gttcttttat tctttttcca acatcacata catttatcat attcatacac
     4441 ctctcataaa aagaatagca cactcttgtc ataatttttt aaataaaaaa attatgacaa
     4501 aacaaggaag caatttattg atgctgctta aaaatctaaa attgatgagt tcctatcaaa
     4561 aatcgtatct tcaacctcaa aacagtactt aaagctatcc gactcggttt acattgtcaa
     4621 atttagattt tatttgagca taactttcta gtttgctttt tgatttttgt ttaatatagt
     4681 agcaaaaatt gaaggaaata tctccacaag aaaacgcata ctattaagct ttttcaagac
     4741 ctaataatat gcgctgttct gatttgaaag atattccatt attattttac tgtaatcaag
     4801 ccatctggct ctactgtgaa ttctggcttg tctgccagtg ttccgtctgg tttgaggtag
     4861 taccagcctg ttccgtccgc tgactggata aaggcatttg ataccatggc gccttcttta
     4921 gcgtctaagt agtaccaagt gtccttgtac ttgacccagc ctgtcttcat ggcaccttct
     4981 tcgttgaaat agtaccactt atcagcgatt ttcttccagc ctgtagccat ttcgcctgag
     5041 ttgtcgaacc agtaccagtt gccgtctgtg tgcttcctcc agcggtctgc aagcatatag
     5101 cctgaactgt caaagtagta ccaagtgcca ttgattttct caaacttgtc ttttggataa
     5161 gagccgtctg aatgtacgta ccagtagcca gtgtcattct tctgccagcc tgtttcaatc
     5221 gtcaagccgt tctcaatatc atgcttaaac tgctcacggc taatgcccca ttttgccaag
     5281 taagggtatg gatccacatg gtctgagtgg ttgtttggtt ggttattcgt gcaatactcg
     5341 tgcgttttaa ttccagctaa actccctgta tcaagcgttt tcggcaaacc tgcttcatct
     5401 gctagattgc gtaagagttc gatataaagg cggtagtccg tcatgaactc ttctttagtt
     5461 gaatggcttt caatcagttc aaccgctgca taggtctcag cattccaacc gcccccaacg
     5521 tcccaggcac cattatcaac aggtcctacc tgcatgatgc aaccgttccc aacaatgtgc
     5581 gagaaaaaac ctaattctgg gtctttccgc cagtgataat ccgcttcatt ctgtacggtt
     5641 gaatgcggat tcccagttga gtgtgcgtgt acttgcctat atggttgcac gccgacttga
     5701 ggcaaatctg ttcttaattt actcacatta atttccatat tctactcctt atcaattaaa
     5761 acaactcatt ttttacaatc cagaaccaga aactccttta tttctacctt acaaagaaga
     5821 caatcttagt cacgattagg cttgtagata gaacttcaaa acgcactatt ttgacactgt
     5881 aaataggact gacaaggtct gcattctatc tacaataaca ccccagacta aaaagctttt
     5941 caaaagtata tttttacagt ctctatatgt ccttttcata aatactatac tttattatat
     6001 catataaaag aagtcaaaag tctgttaaac tattttcaac accaaactaa agacgagaac
     6061 acaagttttt tcgattttca ctagaggaaa tggattttat tcagtaaatc caactaggat
     6121 tgcactttgg ttgccaagat tgccttgcct tcttttatca agggatgacg gaataatgag
     6181 aagtacagtt gaactgtcat ggcaacccag ataagaggtt cacaaaggat aacaccctta
     6241 tatcctgccc aaggaataat caaaaccaca aaaacgattt ttccgattag ttcaataaag
     6301 ctagaaacta gaggaaggat cttttgcccc aagccctgca agcaattgcg ataaatcaac
     6361 aagaggctca aaatgggata aaaggttgaa ctgatttgca gatagagact tccattttct
     6421 atcaagtaac catctgtcga actagccaag aaggaaacca aagctggact ggcaaaaaag
     6481 aggaaaatac aaacaaaaac tgcccaggat atacttaaac gactgccgat tcgaagacct
     6541 tgaacaatac ggtcaggtcg cttagctcct agattctgag aagcaaaggt cgtcattgat
     6601 gcagaaatag cggtcatagg aagaagggca aaggtcataa tgcgtcgagc tgccgtctgg
     6661 gcactaataa tcactgcacc aaatgtatta acagaaaact gtaaaatcac actgccgata
     6721 gatacaattg aactcatcaa gcccatagcc aaaccttgct ccaagagatc cgcgtacaag
     6781 cttttgtccc atttgaaatg tttaaactgt ggcaagagtt ctggcacact tttacgaata
     6841 taataaaagc agagaaccgc tgataaacct tgcgaaataa tggtagcaag tcctgcggat
     6901 tgaactccca gatgcaattg cgtaataaaa tagagatcca gaaccacatt aaccaaggca
     6961 gagaaaatca gaaatcccag ggctgctaga ctgtcaccaa tagaccgcaa caagcctgca
     7021 aaaagattat aagcaaagct gacacctaca caggtcacaa tcatagaaat atattgataa
     7081 gattgaggaa gaatttctgc aggagtatct aagtattgca agagaggata caagccaaga
     7141 aagcccagca acataactag aatgctcaaa agagcaccta aaatccaggt ggctgctact
     7201 gcttccttga ttttagtgaa attccgagcc ccataataac gagcaatgac aatccccatg
     7261 ccattgccaa caccaagtgt aaagcctaca atcaggtcaa aaatcgctgt cgtcgctcct
     7321 actgcagcca aggattcttg accaagaaat cgtccaacaa tcaagacatc agcagtgtta
     7381 tagagctgtt gaaaaatatt tgatagcaag attggaaagg tgaagcttaa gagcgaggga
     7441 agaatcggac catgtatcag gtccactgtt cgttttttat tcataaagct attatatcag
     7501 ctttccagag gagcgacaag aaacagcaaa cttatatata gcggaatgaa ataaggacag
     7561 tcaaatcgat ttttaacaat gttttagaag tagatgtgta ctattctagt ttcgatctat
     7621 tatagttggt tgagtttgga atagtacgct gtagctgcta aaaca
//
LOCUS       DBERMM010000064         7224 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.066, whole genome shotgun sequence.
ACCESSION   DBERMM010000064 DBERMM010000000
VERSION     DBERMM010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7224
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.066"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            1293..1577
                     /locus_tag="ACL8AS_001955"
     CDS             1293..1577
                     /locus_tag="ACL8AS_001955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002923859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229754.1"
                     /translation="MDWYDYMIQASKQSQFNASHWFRYLRKVIFEDYSYLTNQDVEKL
                     LDSKELTRFQKISLKYAFQEHTPTHKYVISLNKPAKLTNVQKLMEKYKHG"
     gene            1904..2122
                     /locus_tag="ACL8AS_001956"
     CDS             1904..2122
                     /locus_tag="ACL8AS_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229755.1"
                     /translation="MMSIREQDLKDIGAIIKYKNFHSPFDTFKYLKDMGFDTIDLSVL
                     LEGFSYAYGMDWLEKFFKENQDKLREFY"
     gene            complement(2489..4813)
                     /gene="pflB"
                     /locus_tag="ACL8AS_001957"
     CDS             complement(2489..4813)
                     /gene="pflB"
                     /locus_tag="ACL8AS_001957"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008861 - formate C-acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HGS1229756.1"
                     /translation="MVVKTVVEAQDIFDKAWEGFKGVDWKEKASVSRFVQANYTPYDG
                     DESFLAGPTERSLHIKKIVEETKAHYEETRFPMDTRPTSIADIPAGFIDKENEVIFGI
                     QNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIR
                     RARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAIKEIDEETIRLRE
                     EVNLQYQALQQVVRLGDLYGVDVRKPAMNVKEAIQWVNIAFMAVCRVINGAATSLGRV
                     PIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDQLYSGDPTFITTS
                     MAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDKLPYNFRRYCMHMSHKHS
                     SIQYEGVTTMAKDGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNG
                     GYDDVHKDYKVFDIEPIRDEVLEFESVKANFEKSLDWLTDTYVDALNIIHYMTDRYNY
                     EAVQMAFLPTKQRANMGFGICGFANTVDTLSAIKYATVKPIRDEDGYIYDYETIGDYP
                     RWGEDDPRSNELAEWLIEAYTTRLRSHKLYKDAEATVSLLTITSNVAYSKQTGNSPVH
                     KGVYLNEDGSVNLSKLEFFSPGANPSNKAKGGWLQNLNSLSSLDFSYAADGISLTTQV
                     SPRALGKTRDEQVDNLVTILDGYFENGGQHVNLNVMDLNDVYEKIMSGEDVIVRISGY
                     CVNTKYLTPEQKTELTQRVFHEVLSMDDALDALS"
     gene            5161..6222
                     /gene="dinB"
                     /locus_tag="ACL8AS_001958"
     CDS             5161..6222
                     /gene="dinB"
                     /locus_tag="ACL8AS_001958"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003684 - damaged DNA binding [Evidence
                     IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HGS1229757.1"
                     /translation="MLIFPLLNDLSRKIIHIDMDAFFAAVEIRDNPKLRGKPVIIGSD
                     PRQTGGRGVVSTCSYEARAFGVHSAMSSKEAYERCPQAVFISGNYEKYKSVGLQIRAI
                     FKRYTDLIEPMSIDEAYLDVTENKLGIKSAVKIARLIQKDIWQELHLTASAGVSYNKF
                     LAKMASDYQKPHGLTVILPEQAEDFLKQMDISKFHGVGKKTVERLHQMGVFTGADLLE
                     VPEVTLIDRFGRLGYDLYRKARGIHNSPVKSNRIRKSIGKEKTYGKILLAEEDIKKEL
                     TLLSEKVALNLHQQEKAGKIVILKIRYEDFSTLTKRKSLAQKTQDASQISQIALQLYE
                     ELSKKERGVRLLGITMTGF"
     gene            complement(6369..7214)
                     /locus_tag="ACL8AS_001959"
     CDS             complement(6369..7214)
                     /locus_tag="ACL8AS_001959"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA];
                     GO_process: GO:0016311 - dephosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HGS1229758.1"
                     /translation="MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNE
                     AFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGV
                     FKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYI
                     GLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKA
                     GELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSF
                     VRLFV"
BASE COUNT         2363 a         1359 c         1363 g         2139 t
ORIGIN      
        1 ctaggaagct agctgcaggc tgctcaaaac actgttttga ggttgtagat agaactgacg
       61 aagtcagtaa catctatacg gtaaggcgac gctgacgtgg tttgaagaga ttttcgaaaa
      121 gtattagtta aatcttgttt aatatctcta caccatacta ttttacatat attatttagc
      181 gccacatagt actgaactct ctccaaaaac ggttatgcct ctttgaatag ggcgttatca
      241 caagaaaagc atctccacgt ttcaacttca tatggctcaa aaacaatcaa ttgatgctaa
      301 aacctgtacc tagatgtttc ggttcataaa accatgaaac tgtaaaagtg gatgaaattg
      361 atagcgatag tcaaatcaag aggcatcata actctaaaaa gtcacaatat ataagttcat
      421 cctcggaaaa atatcattct aattgttgaa atgcctacat gaaaagaaac gtcaaatgct
      481 catgaaacaa cgaatacagg tatcaaaact atgacaaaac aagtccctaa atttactaaa
      541 gacactgctc aactttacac ctgtaaatgg ttgttgtata ataaagttac aaagatgtac
      601 gaccacactg ttgtaaatca tagtgttcgc gaatatatta ctgatagcat ttctacaaat
      661 acaattgaag agactggata ggctttaaac gaaatatgtc agtgttttgg cattcctagc
      721 cttcatatca tttaaagaat tgtatagata aaattttttc caatacagac actcgtaaca
      781 actgcttcat ttttctacca acatatttag gaacaggata agatacaaga gtattaatcc
      841 atagctcagt tctataccaa tctaagacaa ataagctaaa aaaacgattg ataataagca
      901 aatagattcc aaattttctc tatctgctca ttttaataaa caatactagt gtaactatcc
      961 ttccagtcag aagcttgtca aatcacaccg aaaattcttc taaaatttat ctcgttaggc
     1021 aatcaagcaa aaactcgacg atagtacaaa cattatcata cagaattgac ttcctaaatt
     1081 atatacttta gtaatgtttt cggataagaa aaaagattca ttttacattt ctaaacattc
     1141 ttttctaaga tgaaaaacag aatttttcga ttgtgattta aagcaacaag aagattttca
     1201 gtatcatcct atagatacga gctaattaag aaaaactaca tttttgaata taaactacaa
     1261 taatataaac taaattttat aggaggaaga caatggattg gtacgattat atgatacagg
     1321 catccaaaca atcacaattc aacgcaagcc attggtttcg ctatttgcga aaagttattt
     1381 ttgaagacta ttcttattta acaaaccaag atgtagaaaa gttgctagac tccaaagaac
     1441 taacccgttt tcaaaaaatt agcttgaagt atgcctttca agagcatact ccaactcata
     1501 aatatgtgat ttcattaaat aaacctgcta agttaaccaa tgttcaaaaa ttgatggaga
     1561 aatacaaaca tggataaaat gaaaccggtc ttccaagccc taaataagaa attaattcag
     1621 gaaaatctga ctttaacaat tatggttatg tcttagaata tcatggttta cgtgccacac
     1681 aagatgttga tgctttttat gaccaaaatc agaaaatcaa tgaaattatt gctcgtgtag
     1741 gaaaacagtt taatcttaac atccacgaag agttatggct caacaatcat gttgcaaagc
     1801 aaatatgaac aaacaacctc ccttaagttt atgcgaatcc ttgtactcat ttgagaatct
     1861 gaccgtttta gtagtcccta ttgagtatgt gttaggaatg aagatgatga gtatcagaga
     1921 gcaggatttg aaagatattg gtgcaattat taaatacaaa aactttcatt caccattcga
     1981 tacctttaaa tatttaaaag acatgggatt tgatactatt gacctctctg ttctattaga
     2041 aggttttagt tatgcttatg gtatggattg gttagaaaaa ttttttaaag aaaatcaaga
     2101 taaacttcgc gaattttatt aacagtatca aacaagatga ttgtcaatta gccagtcgtc
     2161 ttatttttat gatggaatga aataaaatct gaacaaatcg cttagagaat tccagtcaat
     2221 ttctagcgct gtttgagacg tttcagtgga ctatagtaaa atgaaataag aataggacaa
     2281 atcgatcagg acagtcaaat cgatttctaa gaatgtttta gaaataaagg tgtactattc
     2341 tagtttcaat ctactatatt tcagattcgg tccactattc cttcccaaaa acattgcata
     2401 ttgcgtcaaa ggaattgctc acactatccc aagcacaaaa ccctcagtcg attgaccgag
     2461 ggttcctttt tattattcaa gaacttgatt agctcaatgc atccaaggcg tcatccattg
     2521 aaagaacttc gtggaagaca cgttgtgtca attcagtttt ttgttctgga gtgaggtatt
     2581 tagtgtttac acagtatcca gagatacgta cgataacgtc ttcgcctgac atgatctttt
     2641 cgtaaacatc gttcaagtcc ataacgttca agttaacgtg ttgtccaccg ttttcgaagt
     2701 aaccatcaag gattgttacc aagttatcaa cttgttcatc acgagtctta ccaagagcgc
     2761 gaggtgatac ttgtgtagtc aatgagatac cgtcagctgc ataactaaag tcaaggctag
     2821 aaagtgagtt caagttttgc aaccaaccac ctttagcttt gttagatggg ttagcacctg
     2881 gtgagaagaa ttcaagttta gacaagttca cagaaccatc ttcgttgagg tatacacctt
     2941 tgtgaactgg tgagttacca gtttgtttag agtaagcaac gttagatgtg attgtcaaaa
     3001 gtgatactgt agcttctgcg tctttgtata gtttgtggct acgtagacga gttgtgtaag
     3061 cttcgatcaa ccattctgcc aattcgtttg aacgtgggtc atcttcaccc cagcgtgggt
     3121 agtcaccgat tgtttcgtaa tcgtagatgt agccatcttc gtcacggatt ggtttaactg
     3181 tagcgtattt gatagctgac aatgtatcaa cagtgttagc aaatccacag ataccgaatc
     3241 ccatgttggc acgttgttta gttggcaaga aggccatttg aacagcttcg tagttgtacc
     3301 tatcagtcat gtagtggatg atgttcaagg catctacgta agtgtcagtc aaccagtcaa
     3361 gagatttttc aaagttcgct ttaactgatt caaattcaag aacttcgtca cggattggtt
     3421 cgatatcaaa tactttgtag tctttgtgaa catcgtcgta accaccattc aaaccagtaa
     3481 gaagggcttt aagaacgttt acacgagcac cgaagtactg gatgttgtgg cgttgttctt
     3541 cattttctgg atcaagtgga gacacacagc atgagataca gctcatttca ccatatccgt
     3601 ctttagccat tgttgttaca ccttcgtatt ggatagaaga gtgtttgtgg ctcatgtgca
     3661 tacagtagcg acggaagttg tatggcaatt tgtcagtcca aagaactgtc aagtttggct
     3721 ctggagagtt accgatgttg tcaagagtgt tcaagaaacg gtagtccatc ttagtaacac
     3781 ggtgacgacc gtcgttaccc ataccagcca tagaagttgt gatgaatgtt gggtcacctg
     3841 agtacaattg gtcataagct tttgtacgag caaatttaac tgtacgaagt ttcataacga
     3901 aatcatcaac gaattcttgg atttctgatt cagtaaatgt accacgagca aggtcacgtt
     3961 ctgcaaagat gtccaatacg attggtacac gacctagaga tgtagcagca ccgttaatca
     4021 cacggcagac agccatgaaa gcaatgttaa cccattggat tgcttctttc acgttcatcg
     4081 ctggtttgcg aacatcaacc ccgtaaaggt cacccaggcg aacaacttgt tgcaatgctt
     4141 ggtattgaag gtttacttct tcacgaagac ggattgtttc ttcatcgatt tctttgattg
     4201 cattccagtc atttactttt tcttgcatca agtagtctgc accgtaaaga gcaagacgtg
     4261 cgtaaacacc gatgatacgt ccgcgtgagt atgcatctgg aagaccagtt acagtgtgtg
     4321 cgtgacgagc gcgacgaata tttgaagtgt aggcacggaa aataccgtcg ttaactgttg
     4381 ttacatattt agtgaagatt tcgtgaacag ctgggtctgg ttcgtatcca ttttctttca
     4441 aagtagtttc agccatacgg ataccacctt ttggcatgaa gttcaatttg aagagttcat
     4501 cgttttggat accgaagata acttcatttt ctttgtcgat aaatccagca gggatatcag
     4561 cgatagatgt tggacgagtg tccattggga aacgagtttc ttcgtagtgt gctttagttt
     4621 cttctacaat tttcttgatg tgaagtgaac gctctgttgg tcctgcaagg aagctttcgt
     4681 ctccatcata aggtgtgtag ttagcttgta caaatcgtga tacacttgct ttttctttcc
     4741 aatctacgcc tttgaagcct tcccaagctt tgtcaaaaat atcttgtgct tcaacaactg
     4801 tcttaacaac catattaatg tcctcttttt tctagtaaca gtcatctgtt acattcataa
     4861 gacaagtata ccatatagta accgatttca acaagtgaaa attccctatt tttacacttt
     4921 cttttctaaa acagtctata ttttatttca aactgtatta tatttttgaa aaaataaagt
     4981 ccttttttct ttttttcaga aaaaagggta taataaaaga aaataagcag taacactcaa
     5041 tggaaatcga aaagcaaact aggaagctag ccgcagattg ctcaaaacac tgttttgagg
     5101 ttgcagatag agctgacgtg gtttgaagag attttcgaag agtataaaaa ggtgctaggc
     5161 atgttgattt ttcctttgtt aaatgatttg tcaagaaaaa tcatccatat tgacatggat
     5221 gccttttttg ctgcagtgga aatcagggat aatcctaaac tcagaggaaa acctgtcatt
     5281 attggaagcg accctcggca aacaggtgga cggggagtcg tttctacctg tagttatgag
     5341 gcaagagctt ttggtgtcca ttctgccatg agttccaagg aagcttatga acgttgtccc
     5401 caggctgtct ttatctcagg gaattatgag aaatacaagt ctgtgggact ccagattcga
     5461 gctattttta agcgctatac agatttgatt gaacccatga gcattgacga agcctatttg
     5521 gatgtgacag aaaataaact cggtatcaag tcagcggtca aaattgctcg cctcattcaa
     5581 aaagatatct ggcaagaact ccatctaact gcttccgcag gcgtttctta caacaaattc
     5641 ttagctaaaa tggcgagtga ttatcaaaaa ccacatggtt tgacagtgat tctacctgaa
     5701 caggctgagg attttctcaa acaaatggat atttccaaat ttcatggagt aggaaaaaag
     5761 acagtagaac gtcttcatca aatgggcgtt tttactggtg ctgatttact tgaagttcct
     5821 gaggtaaccc taatagaccg ttttggtaga ctaggctatg atctgtatcg aaaggctcgt
     5881 ggcattcaca actctccagt caaatccaat cgcatccgta aatcaatcgg caaggagaaa
     5941 acctacggga agattctcct tgctgaggaa gatatcaaaa aagagctgac tcttctatca
     6001 gaaaaagtcg ctctcaatct acatcaacaa gaaaaagctg gaaaaattgt cattttgaaa
     6061 atccgctacg aggacttttc aactcttacc aaacgaaaaa gtcttgctca aaaaacacaa
     6121 gatgctagtc agataagcca aatagccctg caactctatg aagaattaag caagaaagaa
     6181 agaggtgtcc gcctattggg gattaccatg actggatttt aaagctcaat gaaaatcaaa
     6241 gagcaaacta ggaggctagc cgcaggctgc tcaaaacact gttttgaggt tgcagataaa
     6301 gctgacgcgg tttgaagaga ttttcgaaga gtataaaacc ttgaagagtt gccccttcaa
     6361 ggtttttctt atacaaataa acggacaaaa ctgtaaagta gcaaaacact accaagcacg
     6421 atacggtatt taccaaaaag ggtgaagtcg tgttttttca catagctggt caagaagcga
     6481 atagccacca tgctgaccgc aaaagctact cccatcgcga ccaagagcaa aaacaattgc
     6541 ccaaagctca agagttctcc ggctttcaca aatttgaaaa tctttaaggc actagctcca
     6601 aacataacag gaatcccaag atagaaggta aattctgtca caactgaacg actggttcca
     6661 tttaacaaac caccgacaat cgttgcacct gaacggctag tccctggtaa aagagcaaga
     6721 acttggaaga gtccgatata gaaagcggtc gtataaggaa gcttgtccaa ctctgttaca
     6781 cttggctcga tagcacgcgc tttattgcgc ttttccaaat agatgaaggc aaccccgtag
     6841 ataatcaaca tgagagcaac tgaaaccatg ttatggaagt gggtatcaaa ccaatcatca
     6901 aatttaaaga caccaagtaa aggtaaagta gcaatcaaga ccttcaacca tagtctccaa
     6961 gtcttacgaa cttcctgttt gtccttagtc ggtttaaaag gattgagctt gttaaaataa
     7021 atcaccataa ctgctaaaat agcaccaagc tgaatcacga cattaaacat ggacataaag
     7081 gcttcatttt gattttggta ttggatgaat tcctctgcta aaatcaagtg acctgtactg
     7141 gaaatcggca accattccgt aattccttca acaatcccga agaagataga ttttaaaatt
     7201 tcaataagat acatagatta ctcc
//
LOCUS       DBERMM010000065         7101 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.067, whole genome shotgun sequence.
ACCESSION   DBERMM010000065 DBERMM010000000
VERSION     DBERMM010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7101)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7101)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7101
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.067"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            226..6657
                     /locus_tag="ACL8AS_001960"
     CDS             226..6657
                     /locus_tag="ACL8AS_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008236 - serine-type peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HGS1229759.1"
                     /translation="MKKSTVLSLTTAAVILAAYAPNEVVLADTSNSEDALSISDKEKV
                     VVDKETENKEKHKDIHNAIETSKDTEEKKTTIIEEKEVVSKNPVIDNNTSNEEARIKE
                     DSNQSQGDNAHSSANKNTENPKKEDKVVYIAEFKDKESGEKAIKQLSSLKNTKVLYTY
                     DRIFNGSAIETTPDNLDKIKQIEGISSVERAQKVQPMMNHARKEIGVEEAIDYLKSIN
                     APFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDKI
                     PHAFNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNAQ
                     IFSYKMYSDAGSGFAGDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRAL
                     RKAGIPMVVATGNYATSASSSSWDLVANNHLKMTDTGNVTRTAAHEDAIAVASAKNQT
                     VEFDKVNIGGESFKYRNIGAFFDKNKITTNEDGTKAPSKLKFVYIGKGQDQDLIGLDL
                     RGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEGT
                     KSQVFSISGDDGVKLWNMINPDKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNVG
                     DEKEIDFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVIN
                     GKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIALQ
                     NTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATFKNTDSKGLVNSYGS
                     ISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAITTDSLTDRLKLDETYKDEKSPDGK
                     QIVPEIHPEKVKGANITFEHDTFTIGANSSFDLNAVINVGEAKNKNKFVESFIHFESV
                     EEMEALNSNGKKINFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSRSKTLGGYDDDGK
                     PKIPGTLNKGIGGEHGIDKFNPAGVIQNRKDKNRTSLDQDPDLFAFNNQGVHAESTSG
                     SKIANIYPLDSNGNPQDAQLERGLTPSPLVLRSAEEGLISIVNTNKEGENQKDLKVVS
                     REHFIRGILNSKGNDAKGIKSSKLKVWGDLKWDGLIYNPRGREENAPESKDNQDPATK
                     IRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDFSNPEKIKLIT
                     KDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEVTYA
                     GEGQGRNRKLDKDGNTIYEISGAGDLRGKIIEVIALDGASNFTKIHRIKFANQADEKG
                     MISYYLVDPDQDSSKYQKLGEIPESKFKNLKNVKDDSLNKETAEVENNLLVDNQSIEG
                     KSLFNIHKTISTIRDFENKDLKKLIKKKYKQEDDFVNGGTRTVERDYKYDDKGNIIAY
                     DDGTDLEYETEKLDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNNYKSIEI
                     KATKYDFHSKTMTFDLYANINDIVDGLAFAGDMRLFVKDNDQKKAEIKIRMPEKIKET
                     KSEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKGY
                     ALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRALSETTIYADSRNVEDGRSTQ
                     SVLMSALDGFNIIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYTGEDKS
                     NVEAIKEDGSMLFIDTKPVNLSMDKNYFNPSKSNKIYVRNPEFYLRGKISDKGGFNWE
                     LRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGFPDKVTDMDG
                     NVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGKSVVFNINDKRN
                     NGFDGEIQEQHIYINGKEYTSFNDIKQIIDKTLNIKIVVKDFARNTTVKEFILNKDTG
                     EVSELKPHRVTVTIQNGKEMSSTIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKKD
                     AGYVINLSKDTFIKPVFKKIEEKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDLQ
                     REDHSQKSDSTKDVTATVLDKNNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIVG
                     IFLGLKKKNQD"
BASE COUNT         2788 a          988 c         1356 g         1969 t
ORIGIN      
        1 taatcttatt ttttaacgtg tgctaaaaaa taaattaatg caggttaatt tttcttgaat
       61 taaatttttt taaatgatat actgttttta tggagagata acaattatat ataaatgtac
      121 tactccattt cctagataat acttagtaaa actttttata acaaaggcta gcaaagttaa
      181 agtttattat ctattggaag ttatataaat atgtaaggaa ttaaaatgaa aaaaagtaca
      241 gtattgtcat taaccacagc tgcagttatt ttagcagcct atgcccctaa tgaggtagtc
      301 ttagcagaca catctaactc tgaagatgct ttaagcatct ctgataaaga aaaagtagta
      361 gtagataagg aaacagaaaa taaagagaaa cataaagata ttcataatgc tatagaaact
      421 tcaaaggata ctgaagaaaa gaaaacaaca attattgagg aaaaagaagt tgttagtaaa
      481 aatcctgtga tagacaataa cactagcaat gaagaagcaa gaatcaaaga agattccaat
      541 caatctcaag gagataatgc acactcgtct gcaaataaaa acacagaaaa tcccaaaaaa
      601 gaagataaag ttgtctatat tgctgaattt aaagataaag aatctggaga aaaagcaatc
      661 aagcaactat ccagtcttaa gaatacaaaa gttttatata cttatgatag aatttttaac
      721 ggtagtgcca tagaaacaac tccagataac ttggacaaaa ttaaacaaat agaaggtatt
      781 tcatcggttg aaagggcaca aaaagtccaa cccatgatga atcatgccag aaaggaaatt
      841 ggagttgagg aagctattga ttacctaaag tctatcaatg ctccgtttgg gaaaaatttt
      901 gatggtagag gtatggtcat ttcaaatatc gatactggaa cagattatag acataaggct
      961 atgagaatcg atgatgatgc caaagcctca atgagattta aaaaagaaga cttaaaaggc
     1021 actgataaaa attattggtt gagtgataaa atccctcatg cgttcaatta ttataatggt
     1081 ggcaaaatca ctgtagaaaa atatgatgat ggaagggatt attttgaccc acatgggatg
     1141 catattgcag ggattcttgc tggaaatgat actgaacaag acatcaaaaa ctttaacggc
     1201 atagatggaa ttgcacctaa tgcacaaatt ttctcttaca aaatgtattc tgacgcagga
     1261 tctgggtttg cgggtgatga aacaatgttt catgctattg aagattctat caaacacaac
     1321 gttgatgttg tttcggtatc atctggtttt acaggaacag gtcttgtagg tgagaaatat
     1381 tggcaagcta ttagggcatt aagaaaagca ggcattccaa tggttgtcgc tacgggtaac
     1441 tatgcgactt ctgcttcaag ttcttcatgg gatttagtag caaataatca tctgaaaatg
     1501 accgacactg gaaatgtaac acgaactgca gcacatgaag atgctatagc ggtcgcttct
     1561 gctaaaaatc aaacagttga gtttgataaa gttaacatag gtggagaaag ttttaaatac
     1621 agaaatatag gggccttttt cgataagaat aaaatcacaa caaatgaaga tggaacaaaa
     1681 gctcctagta aattaaaatt tgtatatata ggcaaggggc aagaccaaga tttgataggt
     1741 ttggatctta ggggcaaaat tgcagtaatg gatagaattt atacaaagga tttaaaaaat
     1801 gcttttaaaa aagctatgga taagggtgca cgcgccatta tggttgtaaa tactgtaaat
     1861 tactacaata gagataattg gacagagctt ccagctatgg gatatgaagc ggatgaaggt
     1921 actaaaagtc aagtgttttc aatttcagga gatgatggtg taaagctatg gaacatgatt
     1981 aatcctgata aaaaaactga agtcaaaaga aataataaag aagattttaa agataaattg
     2041 gagcaatact atccaattga tatggaaagt tttaattcca acaaaccgaa tgtaggtgac
     2101 gaaaaagaga ttgactttaa gtttgcacct gacacagaca aagaactcta taaagaagat
     2161 atcatcgttc cagcaggatc tacatcttgg gggccaagaa tagatttact tttaaaaccc
     2221 gatgtttcag cacctggtaa aaatattaaa tccacgctta atgttattaa tggcaaatca
     2281 acttatggct atatgtcagg aactagtatg gcgactccaa tcgtggcagc ttctactgtt
     2341 ttgattagac cgaaattaaa ggaaatgctt gaaagacctg tattgaaaaa tcttaaggga
     2401 gatgacaaaa tagatcttac aagtcttaca aaaattgccc tacaaaatac tgcacgacct
     2461 atgatggatg caacttcttg gaaagaaaaa agtcaatact ttgcatcacc tagacaacag
     2521 ggagcaggcc taattaatgt ggccaatgct ttgagaaatg aagttgtagc aactttcaaa
     2581 aacactgatt ctaaaggttt ggtaaactca tatggttcca tttctcttaa agaaataaaa
     2641 ggtgataaaa aatactttac aatcaagctt cacaatacat caaacagacc tttgactttt
     2701 aaagtttcag catcagcgat aactacagat tctttaactg acagattaaa acttgatgaa
     2761 acatataaag atgaaaaatc tccagatggt aagcaaattg ttccagaaat tcacccagaa
     2821 aaagtcaaag gagcaaatat cacatttgag catgatactt tcactatagg cgcaaattct
     2881 agctttgatt tgaatgcggt tataaatgtt ggagaggcca aaaacaaaaa taaatttgta
     2941 gaatcattta ttcattttga gtcagtggaa gaaatggaag ctctaaactc caacgggaag
     3001 aaaataaact tccaaccttc tttgtcgatg cctctaatgg gatttgctgg gaattggaac
     3061 cacgaaccaa tccttgataa atgggcttgg gaagaagggt caagatcaaa aacactggga
     3121 ggttatgatg atgatggtaa accgaaaatt ccaggaacct taaataaggg aattggtgga
     3181 gaacatggta tagataaatt taatccagca ggagttatac aaaatagaaa agataaaaat
     3241 agaacatctc tagatcaaga tccagactta tttgccttta acaaccaagg tgttcatgca
     3301 gaatccacta gtggttctaa gattgctaac atttatcctt tagattcaaa tggaaatcct
     3361 caagatgctc aactagaaag aggactaact ccatctccac ttgttctaag aagtgcagaa
     3421 gaaggactaa tttcaattgt aaacaccaac aaagaaggag aaaaccaaaa agaccttaaa
     3481 gttgtatcaa gagagcactt cataagagga attctaaatt ctaagggaaa tgacgctaag
     3541 ggtatcaaat catccaaact aaaagtttgg ggtgacttga aatgggatgg actcatctat
     3601 aacccaagag gtagagaaga aaatgcccca gaaagtaagg ataaccaaga tccagctact
     3661 aagatacgag gacaatttga accgattgcg gaaggtcaat atttctataa atttaaatat
     3721 agattaacta aagattaccc atggcaggtt tcctatattc ctgtaaaaat tgataacaca
     3781 gcccctaaga ttgtttcggt tgatttttca aatcctgaaa aaattaagct aatcacaaag
     3841 gatacttatc acaaggtaaa agatcaatac aagaatgaaa ctttatttgc tagagatcaa
     3901 aaagaacatc ctgaaaaatt tgatgagatt gcaaatgagg tgtggtatgc aggagctgct
     3961 cttgttaatg aagatggaga ggttgagaaa aatcttgaag taacttatgc aggtgagggt
     4021 caaggaagaa ataggaagct tgataaagat gggaatacta tctatgaaat tagcggagca
     4081 ggagatctaa gaggaaaaat catcgaagta atcgccctag atggagcaag caactttacc
     4141 aaaatccata ggattaaatt tgctaatcaa gctgatgaaa aagggatgat ttcctattat
     4201 ctagtagatc ctgatcagga ttcatctaaa taccaaaagc ttggcgaaat tcctgaatct
     4261 aaatttaaga atttaaaaaa tgttaaagat gatagcctaa acaaagagac agctgaggtg
     4321 gaaaataacc ttttagtaga taatcagtct atcgaaggaa aatctctctt taatattcat
     4381 aaaactattt caacaattag agactttgaa aataaagacc taaagaaact cattaaaaag
     4441 aaatataagc aagaagacga ctttgtaaat ggtggaacaa gaacagtaga gcgtgattat
     4501 aaatacgatg ataaaggaaa tataatagcc tacgatgatg ggactgatct agaatatgaa
     4561 actgagaaac ttgacgaaat caaatcaaaa atttatggtg ttctaagtcc gtctaaagat
     4621 ggacactttg aaattcttgg aaagataagt aatgtttcta aaaatgccaa ggtatattat
     4681 gggaataact ataaatctat agaaatcaaa gcgaccaagt atgatttcca ctcaaaaacg
     4741 atgacatttg atctatacgc taatattaat gatattgtgg atggattagc ttttgcagga
     4801 gatatgagat tatttgttaa agataatgat cagaaaaaag ctgaaattaa aattagaatg
     4861 cctgaaaaaa ttaaggaaac taaatcagaa tatccctatg tatcaagtta tgggaatgtc
     4921 atagaattag gggaaggaga tctttcaaaa aacaaaccag acaatttaac taaaatggaa
     4981 tctggtaaaa tctattctga ttcagaaaaa caacaatatc tgttaaagga taatatcatt
     5041 ctaagaaaag gctatgcact aaaagtgact acctataatc ctggaaaaac ggatatgtta
     5101 gaaggaaatg gagtctatag caaggaagat atagcaaaaa tacaaaaggc caatcctaat
     5161 ctaagagccc tttcagaaac aacaatttat gctgatagta gaaatgttga agatggaaga
     5221 agtacccaat ctgtattaat gtcggctttg gacggcttta acattataag gtatcaagtg
     5281 tttacattta aaatgaacga taaaggggaa gctatcgata aagacggaaa tcttgtgaca
     5341 gattcttcta aacttgtatt atttggtaag gatgataaag aatacactgg agaggataag
     5401 tccaatgtag aagctataaa agaagatggc tccatgttat ttattgatac caaaccagta
     5461 aacctttcaa tggataagaa ctactttaat ccatctaaat ctaataaaat ttatgtacga
     5521 aatccagaat tttatttaag aggtaagatt tctgataagg gtggttttaa ctgggaattg
     5581 agagttaatg aatcggttgt agataattat ttaatctacg gagatttaca cattgataac
     5641 actagagatt ttaatattaa gctgaatgtt aaagacggtg acatcatgga ctggggaatg
     5701 aaagactata aagcaaacgg atttccagat aaggtaacag atatggatgg aaatgtttat
     5761 cttcaaactg gctatagcga tttgaatgct aaagcagttg gagtccacta tcagttttta
     5821 tatgataatg ttaaacccga agtaaacatt gatcctaagg gaaatactag tatcgaatat
     5881 gctgatggaa aatctgtagt ctttaacatc aatgataaaa gaaataatgg attcgatggt
     5941 gagattcaag aacaacatat ttatataaat ggaaaagaat atacatcatt taatgatatt
     6001 aaacaaataa tagacaagac actaaacatt aagattgttg taaaagattt tgcaagaaat
     6061 acaaccgtaa aagaattcat tttaaataaa gatacgggag aggtaagtga attaaaacct
     6121 catagggtaa ctgtgaccat tcaaaatgga aaagaaatga gttcaacgat agtgtcggaa
     6181 gaagatttta ttttacctgt ttataagggt gaattagaaa aaggatacca atttgatggt
     6241 tgggaaattt ctggtttcga aggtaaaaaa gacgctggct atgttattaa tctatcaaaa
     6301 gataccttta taaaacctgt attcaagaaa atagaggaga aaaaggagga agagaataaa
     6361 cctacttttg atgtatcgaa aaagaaagat aacccacaag taaaccatag tcaattaaat
     6421 gaaagtcaca gaaaagagga tttacaaaga gaagatcatt cacaaaaatc tgattcaact
     6481 aaggatgtta cagctacagt tcttgataaa aacaatatca gtagtaaatc aactactaac
     6541 aatcctaata agttgccaaa aactggaaca gcaagcggag cccagacact attagctgcc
     6601 ggaataatgt ttatagtagg aatttttctt ggattgaaga aaaaaaatca agattaagat
     6661 aaaagctata gaaaaaaatg gtttatgtac tgagattaga tagtgaggtg atgacatagt
     6721 tttgtgaaaa cagccattta taactcaatt atttagttta cttcactatt gatactattt
     6781 ggagttatta atggacttag tttagataac taatgaattg attgaaaggg ttagtattga
     6841 caatattggt catattgatt agaaaataga gtctatcaaa atttaaaggc taatagaggt
     6901 gatgagacaa tttcaaggaa ttaagtagcg tttggttgct taattccttt ttatttggaa
     6961 ggaagttttt cgtaaccgcc caataacgaa gtctattgga cggttacgat atgatcactg
     7021 acttcgtcag tcttatctac aacctcaaaa ctgtgttttg agcaacctgc ggctagcttc
     7081 ctagtttact ctttgatttt c
//
LOCUS       DBERMM010000066         6964 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.068, whole genome shotgun sequence.
ACCESSION   DBERMM010000066 DBERMM010000000
VERSION     DBERMM010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6964)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6964)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6964
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.068"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(34..264)
                     /locus_tag="ACL8AS_001961"
     CDS             complement(34..264)
                     /locus_tag="ACL8AS_001961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000832182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229760.1"
                     /translation="MKRVILLAVIQAVVLFFIIGALAYAFKGDFFYNYLAVVFAPIAG
                     VLRFGTAYITEIVLPRKAAEIAEKRKAGKNSK"
     gene            complement(282..923)
                     /locus_tag="ACL8AS_001962"
     CDS             complement(282..923)
                     /locus_tag="ACL8AS_001962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="HGS1229761.1"
                     /translation="MKLLKNLGWILLALLSFFFIYGFIQGLATASLALGASPYAVTLL
                     YVVLAGVYVYGIYKWYQKAPVYIEKSGFNRFIWLPALVWFLSLVVQFFLPDDPSVNQQ
                     IATDLTLSQPLFSFFAVVIFAPLTEEIVFRGMLARYLFPKQDNSKRTLIFLLVSSLLF
                     ALIHFPGDVQQFFVYFSLGFSLGLAYVSRKGLVYSISLHALNNLVGFLMILML"
     gene            complement(935..1669)
                     /locus_tag="ACL8AS_001963"
     CDS             complement(935..1669)
                     /locus_tag="ACL8AS_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3169 family protein"
                     /protein_id="HGS1229762.1"
                     /translation="MKKKRRLLFLMSIVLGGFLGMFVGMFKARVESHEIILDVKALMP
                     WISAICLLIGFISMFLTFNFLKKSRKFHSLYQEEMDDDLNETYYVQMYRNLEFGTIAF
                     NITGVAIPLAIFISLSEVIILHTNPQTFFLSFLLFVVFLVAQKSLFKTIAIVRQFDLE
                     FFATPKDVLNYINSYDEGERQANLEQSFRILFQLHQYVLPALYIFLIIISFLTGEIQL
                     LAFLLVGAIHVYINVMQLPMVKRYFK"
     gene            complement(1672..1869)
                     /locus_tag="ACL8AS_001964"
     CDS             complement(1672..1869)
                     /locus_tag="ACL8AS_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229763.1"
                     /translation="MNKYKVIYYVVVIALLVSVFLLIGMDLSWFNPYQSDQFVWVYFA
                     LIPVTEWIEKKSKNLASEKGE"
     gene            complement(1869..2075)
                     /locus_tag="ACL8AS_001965"
     CDS             complement(1869..2075)
                     /locus_tag="ACL8AS_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HGS1229764.1"
                     /translation="MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSI
                     IIALKISQIFNETVESVFRLEEDE"
     gene            complement(2085..2399)
                     /locus_tag="ACL8AS_001966"
     CDS             complement(2085..2399)
                     /locus_tag="ACL8AS_001966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229765.1"
                     /translation="MWVLGFILFMIFFYSNNSKKIKKLENKIKKLERKEKGNAEMSRL
                     LQEMIGKEPIITGVYIGPDNWEVVDVDEEWVKLRSVDNTGKEKFKLQRIEDIQTVEFD
                     GE"
     gene            complement(2553..2681)
                     /locus_tag="ACL8AS_001967"
     CDS             complement(2553..2681)
                     /locus_tag="ACL8AS_001967"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229766.1"
                     /translation="MDRTDEVSSKHGFEVVDETDEVSNHTYGKVKLTWFEEILEEY"
     gene            complement(2741..4030)
                     /gene="hisS"
                     /locus_tag="ACL8AS_001968"
     CDS             complement(2741..4030)
                     /gene="hisS"
                     /locus_tag="ACL8AS_001968"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HGS1229767.1"
                     /translation="MKLQKPKGTQDILPAESAKWQYVEGFAREIFKRYNYAEVRTPIF
                     EHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQK
                     PSKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSSNPATDVETIVMAAHFLKEIGIQG
                     VKLHLNTLGNPESRAAYRQALIDYLTPLKETLSKDSQRRLEENPLRVLDSKEKEDKVA
                     VENAPSILDFLDEESQAHFDAVRQMLENLGVDYIIDTNMVRGLDYYNHTIFEFITEIE
                     GNDLTVCAGGRYDGLVAYFGGPETAGFGFGLGVERLLLILEKQGVALPIENALDVYIA
                     VLGDGANVKALELVQALRQQGFKAERDYLNRKLKAQFKSADVFATKTLITLGESEVES
                     GQVTVKNNQTREEVQVSLETISQNFSEIFEKLGFYTQ"
     gene            complement(4108..5355)
                     /locus_tag="ACL8AS_001969"
     CDS             complement(4108..5355)
                     /locus_tag="ACL8AS_001969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter"
                     /protein_id="HGS1229768.1"
                     /translation="MKLLFRNPAYRILTLSRFFNAFGASIFNLVFIVYASTLSQASFA
                     VAMANIVMILPTLFTVFVGIRADYTRDKVKWMVYSGLFQAVLFFLAALVVQQASLFAF
                     SSLCLINVISDIISDFAGGLRMPLIKEKVAEDDLMEAYSFSQFITYISAIGGQAFGVW
                     LLALSVNNFSLVAGINACFFLVSATILFLGKSKLSLSMSSADGENLKNDKLSIKDQFL
                     TIYRNLRLVFLKSGQKNFGFMLFAVLLINSLGGALGGIYNIFFLSHSLLNFSYTEALF
                     INQFCVLVAIIISSLTGNDYFGKQSLPRLMMWATVGLSLVGLANLFNQVVLGLLFLFF
                     TLYVSGKVQPKISAMLMKNLAPEVLAHTSNFLGLLFTLSIPVGTACFSLVAVWNIQLT
                     WMLFVGLSLLAIFLTILNLKNDI"
     gene            complement(5546..6397)
                     /gene="rgg"
                     /locus_tag="ACL8AS_001970"
     CDS             complement(5546..6397)
                     /gene="rgg"
                     /locus_tag="ACL8AS_001970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434947.1"
                     /note="Rgg, as the term is used in Streptococcus
                     pneumoniae, is the lone quorum-sensing system
                     transcriptional regulator related to proteins Rgg1, Rgg2,
                     Rgg3, and Rgg4 of Streptococcus pyogenes; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg"
                     /protein_id="HGS1229769.1"
                     /translation="MEQIGKVFRQLRESRNISLRQATGGQFSPSMLSRFETGQSELSV
                     EKFLFALENISASVEEILFLARGFQYDTDSELRKEITDVLEPKNIAPLEDLYRREYQK
                     HAHSHNKQKHILNAIMIKSYMKSIDERVDLTAEEGKVLHDYLFSTEIWGIYELNLFSV
                     SSPFLSVSLFTRYVREMVRKFDFLMEMSGNRNLFHTILLNGFLASIECEEFTNAYYFK
                     RVIEEHFYKENETYFRIVYLWAEGLLDSKQGRVKEGQKKMEDAVRIFEMLGCNKSAEY
                     YRNTTEC"
     gene            6521..6862
                     /locus_tag="ACL8AS_001971"
     CDS             6521..6862
                     /locus_tag="ACL8AS_001971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003080443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HGS1229770.1"
                     /translation="MRDDIKINDRALALQDQIIEKLEKVFDTDVELDVYNLGLIYEIN
                     LDETGLCKIVMTFTDTACDCAESLPIEIVAGLKQIEGIKDIKVEVTWSPAWKITRISR
                     YGRIALGLPPR"
BASE COUNT         2253 a         1450 c         1277 g         1984 t
ORIGIN      
        1 atacaaaaat ccgatgaact tcaccggact cttttatttt gaatttttgc ctgctttacg
       61 cttttcagcg atttcggctg cctttcgagg caagacaatt tccgttatgt aagccgtccc
      121 aaaacgcagt acacctgcaa taggagcaaa gacaactgct agatagttat agaagaaatc
      181 gcctttgaag gcataagcta gcgctccaat gatgaaaaat agaactactg cctgaatcac
      241 tgctaataaa attactcgtt tcatgtgacc tcctgactct attatagcat gagaatcatc
      301 aaaaagccga ctaaattatt caaagcgtga agagaaatac tgtagaccag accttttctg
      361 ctaacgtaag ccaaacccaa actaaaacca aggctaaaat agacaaaaaa ttgttgcaca
      421 tcacctggaa aatgaatcaa ggcaaataga agactagata ccagaagaaa aatcagggtt
      481 cgtttactat tgtcctgctt aggaaagaga tagcgtgcta acatccctct aaaaacaatc
      541 tcttccgtca aaggagcaaa aataaccaca gcaaagaatg agaaaagtgg ttgagacaag
      601 gtcaagtctg tcgctatttg ctgatttact gaaggatcat ctggcaagaa gaattgaacg
      661 accagagata agaaccaaac caaggcagga agccaaataa atcggttaaa gccgctcttc
      721 tcaatataaa caggagcttt ctgataccat ttgtaaatgc cgtacacata tactccagcc
      781 aagaccacat agagtagagt aacagcatag ggtgaagcgc ctaaagcaag cgacgcagtc
      841 gcgagcccct gaataaagcc atagataaag aaaaaggata gaagggctag aagaatccag
      901 ccaaggtttt taagtaattt catagataac tcctttattt gaaataacgt tttaccatag
      961 gtaactgcat cacattgata taaacatgga tggctcctac aagcaagaaa gctagtaact
     1021 gaatctctcc tgtcaagaaa gaaatgataa taagaaaaat atataaggct ggtaagacat
     1081 attggtgtaa ttggaataaa attcgaaaac tctgttccaa attagcctga cgctcccctt
     1141 catcataaga atttatatag ttcaagacat cctttggtgt agcgaaaaat tccaaatcaa
     1201 actgacgaac aatcgcaatg gttttaaaaa gagatttttg agcgactaag aataccacaa
     1261 agagtaagaa agaaaggaaa aatgtttgag ggtttgtatg caatataatc acctcactta
     1321 atgaaataaa aatagccaat ggaatcgcta cacctgtaat attaaaagca atggttccaa
     1381 actcaagatt ccgatacatt tgcacataat aggtttcatt cagatcgtca tccatttcct
     1441 cttgatacaa ggaatgaaat tttctgcttt tctttaagaa attgaaagtc aaaaacatac
     1501 taatgaaacc tatcagtaaa caaatagctg atatccatgg catcaaggct tttacatcta
     1561 aaataatttc gtgggattcg acacgtgcct taaacatccc tacaaacatg cccaagaacc
     1621 cccccaagac aatagacatc aaaaataaca atctacgttt ctttttcata ttcattctcc
     1681 tttttcactt gctagatttt tggatttctt ttcaatccat tcagttactg ggatgagagc
     1741 aaagtagacc caaacaaatt ggtcgctttg atagggatta aaccagctta ggtccatccc
     1801 aatcagtaga aatacgctga ctaataaagc tatgaccact acataataaa tcactttata
     1861 cttgttcatc actcgtcctc ctccaaacga aataccgatt cgactgtttc gttgaaaatt
     1921 tgagatattt tcagggcaat gataatggat ggggtgtact catcccgttc tagtaggcta
     1981 atggtctgtc tggaaacccc tgccagtttg gctaggtcgg tttgattgag accatcgcga
     2041 gctcgaagct cttttagacg attttttagt tgcacgttac acacctactc tccgtcaaat
     2101 tcaacggttt ggatatcttc aatacgttgc aacttgaatt tttcttttcc cgtattatca
     2161 acactacgta gtttgaccca ttcctcatca acatccacaa cttcccagtt atctggccca
     2221 atatacactc ccgttataat tggttccttt ccaatcattt cttgtaataa tctcgacatt
     2281 tctgcgtttc ctttctcttt tcgctcaagt tttttgattt tattctctag tttcttgatt
     2341 tttttagaat tattagaata aaagaaaatc ataaatagta taaatcctag tacccacatt
     2401 ataactcctt tctgcttcct atttcttaac ttgaattcat tgtaacatat ctttttcttt
     2461 tttgacaatt atagttttca aaaagtttat gatttttgtc attttgcaaa agaaaaaggt
     2521 caggagtaag ttcctgacca ctttatctat cattaatact cttctaaaat ctcttcaaac
     2581 cacgtcagct tcaccttgcc gtaggtatgg ttactgactt cgtcagtttc atctacaacc
     2641 tcaaaaccat gttttgagct gacttcgtca gttctatcca taacttcaaa acagtgtttt
     2701 gagcaatctg cggctagctt cctagtttgc tctttgattt ttattgagta taaaatccta
     2761 gtttttcaaa gatttctgaa aagttttggc tgattgtctc aagtgacact tgcacttctt
     2821 ctcgggtttg gttgttcttg accgtcactt gtccgctttc gacttcgctc tctcccaggg
     2881 tgatgagggt cttagtcgca aagacatcgg ctgacttgaa ctgagctttg agcttacggt
     2941 tgaggtaatc acgctctgct ttgaaacctt gttggcgaag ggcttggact agttctaggg
     3001 ctttgacatt tgctccatca cccaagactg cgatatagac atctagggca ttttcgatag
     3061 ggagggccac gccttgtttt tcaaggatga gaagcagacg ctctacacca agcccaaaac
     3121 caaatccagc agtttcaggg cctccaaagt aagcaaccaa accatcgtag cgaccacccg
     3181 cacagactgt caagtcattg ccctcaatct ctgtgataaa ctcgaaaatg gtgtggttgt
     3241 agtagtccag accacgcacc atattggtat cgatgatgta atctactcca agattttcca
     3301 acatctgacg cacagcatca aaatgagctt ggctttcttc atcaagaaag tccaagatag
     3361 acggcgcatt ctctactgcc accttgtctt ctttttcctt agagtccaag acacgaagag
     3421 gattttcctc caagcgacgt tggctatcct tagacaaggt ctccttgagc ggtgtcaaat
     3481 agtcaatcaa ggcttggcgg taggctgcac ggctctcagg atttccaaga gtgttgaggt
     3541 gcaatttgac accttgaata ccgatttcct tcaaaaaatg ggctgccata acgattgttt
     3601 ccacatcggt agctggattg ctagagccaa aacactcaac accaatctgg tggaattggc
     3661 gcaagcgccc tgcctgtgga cgctcataac ggaacatagg tcccatgtag tagaacttgc
     3721 ttggcttttg cacttctggg gcgaagagtt tattttccac ataggaacgg acaacgggcg
     3781 cagttccttc tggacggagg gtaatatggc ggtcaccctt gtcatagaaa tcgtacattt
     3841 ccttggttac gatatcggtc gtatctccga cagagcggct gataacctcg taatgctcaa
     3901 aaatgggcgt gcgcacttct gcgtagttgt agcgcttgaa aatttcacgg gcaaagccct
     3961 caacgtactg ccatttggca gattcagcag gtaaaatatc ctgcgttcct tttggttttt
     4021 gtaatttcat agggaatcct ctttaaactt aatagtctta ttttaccaca aataaaggga
     4081 ttaaaacagt gagaaaaaaa ttaggattta gatatcattt ttgagattaa gaattgtcaa
     4141 aaaaatagct agcaaggaaa gaccaacaaa tagcatccaa gtcaactgta tattccatac
     4201 ggctactagt gaaaaacaag ctgttcccac aggtatggat aaggtaaaca atagacctaa
     4261 aaaattacta gtatgagcta gaacctctgg agctagattt ttcatgagca tggcactaat
     4321 ctttggttga actttaccag acacatacag agtaaagaag agaaatagca aaccaagcac
     4381 gacttgattg aataaattag ccaaaccaac tagactaagt cctacggtcg cccacatcat
     4441 caatctaggc aaggactgct tcccaaaata atcattgccc gtaaggctac tgatgatgat
     4501 tgctactaaa acacagaatt gattgataaa tagtgcctct gtataagaaa aattcaagag
     4561 agaatggctc aaaaagaaga tattataaat tccacccaaa gcgccaccca aggaattaat
     4621 aagcaagaca gcaaagagca taaaaccaaa gtttttctgt ccacttttaa gaaaaacgag
     4681 acgtaaattt cggtaaattg ttaggaactg gtctttgata gaaagcttat cattttttaa
     4741 gttttcacca tcagcagatg acattgacag gctcaatttg ctttttccta aaaagaggat
     4801 agtggctgat actaggaaaa agcaggcatt gattcccgca acgagagaaa aattgttgac
     4861 cgatagagct aagagccaga ctccgaaagc ttgaccacca atagctgaaa tataggtgat
     4921 gaactgtgaa aaagaataag cctccatcaa atcatcttca gctacttttt ccttaataag
     4981 aggcatacgc aggccacctg caaaatcact gatgatatca ctaatgacat tgatcaaaca
     5041 caggctagaa aaggcaaaga gactagcttg ctgaacaact agggctgcta gaaaaaatag
     5101 aaccgcctga aacaaaccgc tatagaccat ccatttgacc ttgtccctcg tgtaatctgc
     5161 ccgaatccct acaaaaactg taaagagggt cggaagaatc atgacaatat tcgccatagc
     5221 aacagcaaaa gatgcttgtg acaaggtcga tgcatagacg ataaagacca ggttgaaaat
     5281 cgaagcacca aaagcattga agaagcgtga taaagtcaaa attctataag ctggatttct
     5341 aaacaatagt ttcatagata atctccctcc ttgttctaag ttctacatca agaatagctt
     5401 tagtatagca cttatgaatt tgcgaaacga ttcttttgaa tatatgcaac aaacaaaatg
     5461 agcaaaaaaa cgatagaact tttgtaatga cctgagagag ggcaacagtt ctatcgcttc
     5521 aaattttttc ttggtttaca gatattcaac attcggtcgt atttctatag tattcggcag
     5581 atttattaca gccaagcatc tcaaaaatac ggacagcatc ctccatcttt ttctgacctt
     5641 ccttgactct accttgcttg ctatcaagga gaccttctgc ccacagataa acaattcgga
     5701 aataggtctc attttccttg tagaaatgct cttcgataac acgtttaaaa taataggcat
     5761 tggtaaattc ttcacactca atactagcta aaaagccatt caatagtata gtatgaaaaa
     5821 ggtttcgatt gccagacatt tccattagaa aatcgaattt acgtaccatt tctcgtacat
     5881 atctagtaaa aagagaaacg gataaaaatg gagaactgac tgaaaataaa ttgagttcat
     5941 agattcccca gatctcggta gaaaacaaat aatcatgaag gacttttcct tcctctgctg
     6001 ttaagtctac cctttcatct atgctcttca tataagactt gatcataatg gcatttagaa
     6061 tatgtttctg tttgttgtga gaatgggcat gcttttgata ctccctgcga tataagtcct
     6121 caagaggtgc tatattcttt ggttccaaga catctgtaat ttcttttctc aactcagaat
     6181 ctgtatcata ctggaaacct ctcgccagaa agaggatctc ctccacactg gcagatatat
     6241 tttccagagc aaatagaaac ttttccaccg aaagctcact ctgacctgtt tcaaaacggg
     6301 acaacataga cggcgaaaat tgtcctccgg ttgcttgtct cagtgagata tttcttgatt
     6361 ctcgtaattg tctaaagact tttccaatct gctccataga cttccccttg attccgtatt
     6421 ttcttcattt tatcatattt ttcagaaaat tcatcaaaaa cttgccaaat tgtcagaatt
     6481 atgagaaaat agaggatatt tatcacgtgg agggactgct atgagagacg atatcaaaat
     6541 caatgaccgt gctttggcct tgcaagacca aattatcgaa aaactagaga aagtttttga
     6601 tacagatgtg gaattggatg tttacaatct aggtctgatt tatgaaatca atctggatga
     6661 aacggggctc tgcaagattg tcatgacctt caccgatact gcctgtgatt gcgccgaaag
     6721 cctacctatt gaaatcgtgg caggtctgaa acaaatcgag ggtatcaaag atatcaaggt
     6781 tgaagttacc tggtcgcctg cttggaaaat cacacgaatc agtcgctatg gccgtattgc
     6841 ccttggatta ccacctcgtt aagcaggcca atcactttta aagatgaaaa aagcaagccg
     6901 aaaatggctt gctttttgat actcaatgaa aatcaaaggg caaactagaa aactagccgc
     6961 aggt
//
LOCUS       DBERMM010000067         6940 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.069, whole genome shotgun sequence.
ACCESSION   DBERMM010000067 DBERMM010000000
VERSION     DBERMM010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6940)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6940)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6940
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.069"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            313..2292
                     /locus_tag="ACL8AS_001972"
     CDS             313..2292
                     /locus_tag="ACL8AS_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000742236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HGS1229771.1"
                     /translation="MKKNRVFATAGLVLLAAGVLAACSSSKSSDSSAPKAYGYVYTAD
                     PETLDYLISSKNSTTVVTSNGIDGLFTNDNYGNLAPAVAEDWEVSKDGLTYTYKIRKG
                     VKWFTSDGEEYAEVTAKDFVNGLKHAADKKSEAMYLAENSVKGLADYLSGTSTDFSTV
                     GVKAVDDYTLQYTLNQPEPFWNSKLTYSIFWPLNEEFETSKGSDFAKPTDPTSLLYNG
                     PFLLKGLTAKSSVEFVKNEQYWDKENVHLDTINLAYYDGSDQESLERNFTSGAYSYAR
                     LYPTSSNYSKVAEEYKDNIYYTQSGSGIAGLGVNIDRQSYNYTSKTTDSEKVATKKAL
                     LNKDFRQALNFALDRSAYSAQINGKDGAALAVRNLFVKPDFVSAGEKTFGDLVAAQLP
                     AYGDEWKGVNLADGQDGLFNADKAKAEFAKAKKALEADGVQFPIHLDVPVDQASKNYI
                     SRIQSFKQSVETVLGVENVVVDIQQMTSDEFLNITYYAANASSEDWDVSGGVSWGPDY
                     QDPSTYLDILKTTSSETTKTYLGFDNPNSPSVVQVGLKEYDKLVDEAAKETSDLNVRY
                     EKYAAAQAWLTDSSLFIPAMASSGAAPVLSRIVPFTGASAQTGSKGSDVYFKYLKLQD
                     KVVTKEEYEKAREKWLKEKAESNEKAQKELASHVK"
     gene            2359..3855
                     /locus_tag="ACL8AS_001973"
     CDS             2359..3855
                     /locus_tag="ACL8AS_001973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229772.1"
                     /translation="MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYN
                     KIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYI
                     NQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYL
                     RFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVIT
                     QGQGQTKTAQVQFPTGKKTSSVNIYSRIYKSPSQADSREVASYGKDDPYTATESNYQY
                     PSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGTLTFLLALPTIALVY
                     IVRLIGSSIALPDSFPILGAGDWRSYVLPAVILGLLGAPLTAIWIRRYMIDLQSQDFV
                     RFARAKGLSEKEISNKHIFKNAMVPLVSGIPGAIIGVIGGATLTETVFAFPGMGKMLI
                     DSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK"
     gene            3855..4781
                     /gene="oppC"
                     /locus_tag="ACL8AS_001974"
     CDS             3855..4781
                     /gene="oppC"
                     /locus_tag="ACL8AS_001974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide ABC transporter permease OppC"
                     /protein_id="HGS1229773.1"
                     /translation="MSTIDKEKFQFVKRDDFASETIDAPAYSYWKSVFKQFMKKKSTV
                     VMLGILVAIILISFIYPMFSKFDFNDVSKVNDFSVRYIKPNAEHWFGTDSNGKSLFDG
                     VWFGARNSILISVIATVINLVIGVFVGGIWGISKSVDRVMMEVYNVISNIPPLLIVIV
                     LTYSIGAGFWNLIFAMSVTTWIGIAFMIRVQILRYRDLEYNLASRTLGTPTLKIVAKN
                     IMPQLVSVIVTTMTQMLPSFISYEAFLSFFGLGLPITVPSLGRLISDYSQNVTTNAYL
                     FWIPLTTLVLVSLSLFVVGQNLADASDPRTHR"
     gene            4790..5857
                     /locus_tag="ACL8AS_001975"
     CDS             4790..5857
                     /locus_tag="ACL8AS_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229774.1"
                     /translation="MTKEKNVILTARDIVVEFDVRDKVLTAIRGVSLELVEGEVLALV
                     GESGSGKSVLTKTFTGMLEENGRIAQGSIDYRGQDLTALSSHKDWEQIRGAKIATIFQ
                     DPMTSLDPIKTIGSQITEVIVKHQGKTAKEAKELAIDYMNKVGIPDADRRFNEYPFQY
                     SGGMRQRIVIAIALACRPDVLICDEPTTALDVTIQAQIIDLLKSLQNEYHFTTIFITH
                     DLGVVASIADKVAVMYAGEIVEYGTVEEVFYDPRHPYTWSLLSSLPQLADDKGDLYSI
                     PGTPPSLYTDLKGDAFALRSDYAMQIDFEQKAPQFSVSETHWAKTWLLHEDAPKVEKP
                     AVIANLHDKIREKMGFAHLAD"
     gene            5868..6794
                     /locus_tag="ACL8AS_001976"
     CDS             5868..6794
                     /locus_tag="ACL8AS_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1229775.1"
                     /translation="MSEKLVEIKDLEISFGEGSKKFVAVKNANFFINKGETFSLVGES
                     GSGKTTIGRAIIGLNDTSNGDIIFDGQKINGKKSREQAAELIRRIQMIFQDPAASLNE
                     RATVDYIISEGLYNHRLFKDEEERKEKVQNIIREVGLLAEHLTRYPHEFSGGQRQRIG
                     IARALVMQPDFVIADEPISALDVSVRAQVLNLLKKFQKELGLTYLFIAHDLSVVRFIS
                     DRIAVIYKGVIVEVAETEELFNNPIHPYTQALLSAVPIPDPILERKKVLKVYDPSQHD
                     YETDKPSMVEIRPGHYVWANQAELARYQKGLN"
BASE COUNT         2062 a         1296 c         1426 g         2156 t
ORIGIN      
        1 aaactgaatc ttgaatacta gaatgatact tctacaatat tgttataatt taatttgaat
       61 tccaaaatca cattgttccg tccgtatttc attttactgt atgtcttcct aaactccaaa
      121 gtttctgcgt caaatttcct attttcactg tagtctttga cacttcgaac gacaatttga
      181 atcatatatt caaaaaaaaa tgaaaaattt gtgccaacaa gcctaaatat tctgaaaatt
      241 tgtttgattt ttaatggata atgtgatata atggttgtca atctataatt cacataaaca
      301 gaggagtaga aaatgaaaaa aaatcgtgta tttgctacag caggtcttgt tttattagca
      361 gcaggtgtac ttgcagcatg cagttcttca aaatcatctg attcatcagc ccctaaagct
      421 tatggctatg tttatacagc agacccagaa accttggact acctgatttc aagtaaaaat
      481 agtacaacag tagtgacttc aaatgggatt gatggtttat tcactaacga taattacggt
      541 aatcttgctc ctgcagttgc agaggattgg gaagtctcta aggatggttt gacctacact
      601 tataagattc gtaaaggggt taaatggttt acctctgatg gagaagaata tgcagaggtg
      661 acggctaaag attttgtgaa cggtttaaaa cacgcagcag ataaaaaatc agaagctatg
      721 tatttagctg aaaattcggt taaaggcttg gcagattatc tatcaggaac ttcaacagat
      781 ttttcaacag ttggtgtcaa ggcggttgat gattatacgt tacaatacac tttgaaccag
      841 cctgaaccgt tctggaactc taagttgacc tattctattt tctggcctct gaatgaagaa
      901 ttcgaaacat caaaaggaag cgattttgct aaaccaacag atccgacatc cttgctttat
      961 aatggtccat tcttgttgaa agggttgact gcaaaatctt ctgtagagtt tgtaaaaaat
     1021 gagcaatatt gggataaaga aaatgtccac ctagatacta tcaatctagc ttactatgat
     1081 ggatcagatc aggagtcgct agagcgtaac tttactagtg gagcttatag ttatgcccgt
     1141 ctttacccta ccagctccaa ctattctaag gttgcagaag aatacaagga caatatctat
     1201 tacacacaat caggctctgg gattgctggt ctgggtgtga atattgatcg ccaaagttac
     1261 aactatactt ctaaaactac agattcagag aaagtagcta ctaagaaggc attgcttaac
     1321 aaagatttcc gtcaagcctt gaattttgct cttgatcgct cagcttactc agctcaaatc
     1381 aatggtaaag atggagcagc tttagcagtt cgtaatttat ttgtaaaacc agactttgtt
     1441 tcagctggtg agaagacctt tggtgattta gtcgctgctc aacttcctgc ttatggtgat
     1501 gagtggaaag gtgtgaattt agctgatggg caggatggtt tattcaatgc tgacaaggcc
     1561 aaggcagagt ttgcgaaagc taagaaagct ttagaagcag acggcgttca gtttcctatt
     1621 catctggacg ttccagtaga ccaagcatca aaaaactaca tatctcgtat tcagtccttt
     1681 aaacaatctg tagaaacagt tcttggtgtt gaaaatgtcg ttgttgatat tcaacaaatg
     1741 acaagtgatg aattccttaa tattacttac tatgctgcca atgcttcatc tgaggattgg
     1801 gatgtatcgg gaggagtttc atgggggcca gactatcaag acccatctac ttacctggat
     1861 attttaaaaa caactagcag tgaaactaca aaaacatatt taggatttga taatccaaat
     1921 agcccttcag tagttcaagt tggtttgaaa gaatacgata aattagttga tgaagctgcc
     1981 aaagagacaa gcgacttgaa tgtccgttat gaaaaatatg cagcggctca agcatggttg
     2041 acagatagtt cactctttat tcctgctatg gcttcttctg gtgcagcacc agtgctttca
     2101 cgaattgttc catttactgg agcttctgcg caaacaggct ctaaggggtc agatgtttac
     2161 ttcaaatatt tgaaattaca agataaagtg gtgactaagg aagagtatga aaaagctcgt
     2221 gaaaaatggt tgaaagaaaa agctgaatca aatgagaaag ctcaaaaaga attggcaagt
     2281 catgtgaagt aaataatttc taatagaact ttctctccat gaggagaagg ttcttttggg
     2341 atttttaaag gaaataatat gaaaaaatat atttttatgc gtgttttgcg gtcattggtt
     2401 tcgattttct tagtaacgac tttgacctac acgattatct ataccttggt tcctcgaaaa
     2461 ttgattttca agcaggatcc taactataat aaaattgcga caacggctga taaacgtgat
     2521 aactatgaaa atactgtgtt tgagcgtatg ggctacattg agtattacga tactaaagag
     2581 ttgcaagaaa aggcaagtag catggattct tctgtaacag tagaagcaaa tgcgaccaat
     2641 aaagctattt atgaaaagta catcaatcaa ttaggtcatg gttggacttt gggagaattt
     2701 actgaaagtg gtcaattcta tgctactcgt gaaattccaa tttttgaacg tgtttttcac
     2761 ttctatgcta acttgattga cattgaccat acaaataaaa tccaagaccc tgaaaatcca
     2821 gacttgaaac gctaccttcg ttttgaaaat gatccagcta tcggatggtc attggtcggt
     2881 tcaggaacta aacataaata tctcttgtac tttaacagtc agttcccatt tgttcatcaa
     2941 aactttgtga acttgaattt aggtgactct tacccaacct atgctaatac accagttctt
     3001 caggttatta ctcaaggtca aggacaaacc aaaactgccc aagttcagtt cccaacaggt
     3061 aagaaaacgt cttctgtaaa tatttactca agaatctaca agtcacctag tcaggctgac
     3121 tctcgtgaag tagctagcta tgggaaagat gatccttata cagcgactga aagtaattac
     3181 caatatccat ctatgattgt cagctctgct attactggtt tgattggttt ggttcttgcc
     3241 tatgctcttg ccgtgccact tggttcagcc atggctcgtt tcaagaacac ttggattgat
     3301 agcctctcaa cagggacttt gaccttcttg cttgctcttc caacgattgc cttggtttac
     3361 atcgttcgat tgattggatc atctattgcc cttccagatt cattccctat cttgggagct
     3421 ggagattggc gttcttacgt tttaccagca gtcatccttg gtttgttggg tgctcctctt
     3481 acagccattt ggattcgtcg ttacatgatt gacttgcaat ctcaagactt tgttcgtttc
     3541 gctcgtgcaa aaggtttgtc tgaaaaagaa atttcaaaca aacacatctt taaaaatgcc
     3601 atggttccgc tggtttcagg aattcctggt gccattattg gggttatcgg tggtgcaacc
     3661 cttactgaaa cagtcttcgc cttcccaggt atgggtaaaa tgttgattga ctctgtaaaa
     3721 gcatctaata actctatggt cgttggtctt gtcttcatct ttacatgtat ttctatcttc
     3781 tcacgtcttt tgggagatat ttggatgact attattgacc cacgtattaa attgactgag
     3841 aaaggaggca aataatgtct acaatcgata aagaaaaatt tcagtttgta aaacgtgacg
     3901 attttgcctc tgaaactatt gatgcgccag catattctta ctggaaatca gtgtttaaac
     3961 aatttatgaa gaaaaaatca actgtagtca tgttgggaat cttggtagcc atcattttga
     4021 taagtttcat ctacccaatg ttttctaagt ttgatttcaa tgatgtcagc aaggtaaacg
     4081 actttagtgt tcgttatatc aagccaaatg cggagcattg gttcggtact gacagtaacg
     4141 gtaaatcgct ctttgacggt gtctggttcg gagctcgtaa ctccatcctc atttctgtga
     4201 ttgcgacagt gattaacttg gttatcggtg tttttgtcgg tggtatttgg ggtatttcaa
     4261 aatcagttga ccgtgtcatg atggaagttt acaacgtcat ctcaaacatc ccacctcttt
     4321 tgattgttat tgtcttgact tactcaatcg gagctggatt ctggaatctg atttttgcca
     4381 tgagcgtaac aacatggatt ggtattgcct tcatgatccg tgtgcaaatc ttgcgctatc
     4441 gtgacttgga atacaacttg gcgtcacgta ctttgggaac accaaccttg aagattgttg
     4501 ccaaaaatat catgcctcaa ttggtatctg ttattgtgac aaccatgact caaatgcttc
     4561 caagctttat ctcatacgaa gccttcttgt ctttcttcgg tcttggatta ccgattacag
     4621 tgccaagttt gggtcgtttg atttcggatt attcacaaaa cgtaacaacc aatgcttact
     4681 tgttctggat tccattgaca acccttgtct tggtatcctt gtcccttttc gtagttggtc
     4741 aaaacttagc ggatgctagt gatccacgta cacatagata ggagtagaaa tgacaaaaga
     4801 aaaaaatgta attttgactg ctcgcgatat tgtcgtggaa tttgacgttc gtgataaagt
     4861 attgacagcc attcgcggcg tttcccttga actagtcgaa ggagaagtat tagccttggt
     4921 aggtgagtca ggatcaggta aatctgtttt gacaaagacc ttcacaggta tgctcgaaga
     4981 aaatggtcgc attgcccaag gtagtattga ctaccgtggt caggacttga cagctttatc
     5041 ttctcacaag gattgggaac aaattcgtgg tgctaagatt gcgactatct tccaggaccc
     5101 aatgactagt ttggacccca ttaaaacaat tggtagtcag attacagaag ttattgtaaa
     5161 acaccaagga aaaacagcta aagaagcgaa agaattggcc attgactaca tgaataaggt
     5221 tggcattcca gacgcagata gacgttttaa tgaataccca ttccaatatt ctggaggaat
     5281 gcgtcaacgt atcgttattg ctattgccct tgcctgccga cctgatgtct tgatctgtga
     5341 tgagccaaca actgctttgg atgtaactat tcaagctcag attattgatt tgctaaaatc
     5401 tttacaaaac gagtatcatt tcacaacaat ctttattacc cacgaccttg gtgtggtggc
     5461 aagtattgcg gataaggtag cggttatgta tgcaggagaa atcgttgagt atggaacggt
     5521 tgaggaagtc ttctatgacc ctcgccatcc atatacatgg agtctcttgt ctagcttgcc
     5581 tcagcttgct gatgataaag gggatcttta ctcaatccca ggaacacctc cgtcacttta
     5641 tactgacctg aaaggggatg cttttgcctt gcgttctgac tacgcaatgc agattgactt
     5701 cgaacaaaaa gctcctcaat tctcagtatc agagacacat tgggctaaaa cttggcttct
     5761 tcatgaggat gctccaaaag tagaaaaacc agctgtgatt gcaaatctcc atgataagat
     5821 ccgtgaaaaa atgggatttg cccatctggc tgactaggag gaaggaaatg tctgaaaaat
     5881 tagtagaaat caaagattta gaaatttcct tcggtgaagg aagtaagaag tttgtcgcgg
     5941 ttaaaaatgc taacttcttt atcaacaagg gagaaacttt ctcgcttgta ggtgagtccg
     6001 gtagtgggaa aacaactatt ggtcgtgcta tcatcggtct aaatgataca agtaatggag
     6061 atatcatttt tgatggtcaa aagattaatg gtaagaaatc gcgtgaacaa gctgcggaat
     6121 tgattcgtcg aatccagatg attttccaag accctgccgc aagtttgaat gaacgtgcga
     6181 ctgttgatta tattatttct gaaggtcttt acaatcaccg tttatttaag gatgaagaag
     6241 aacgtaaaga gaaagttcaa aatattatcc gtgaagtagg tcttcttgct gagcacttga
     6301 ctcgttaccc tcatgaattc tcaggcggtc aacgtcaacg tatcggtatt gcccgtgcct
     6361 tggtcatgca accagacttt gttattgcag atgagccaat ttcagccttg gacgtttctg
     6421 tacgtgccca agtcttgaac ttgctcaaaa aattccaaaa agagctcggc ctgacctatc
     6481 tcttcatcgc ccatgacttg tcggttgttc gctttatttc agatcgtatc gcagttattt
     6541 acaagggtgt tattgtagag gttgcagaaa cagaagaatt gttcaacaat ccaattcacc
     6601 catatactca agccttgctt tcagcggtac caatcccaga tccaatcttg gaacgtaaga
     6661 aggtcttgaa ggtttacgat ccaagtcaac acgactatga gactgataag ccatctatgg
     6721 tagaaatccg tccaggtcac tatgtttggg cgaaccaagc cgaattggca cgttatcaaa
     6781 aaggactaaa ctagtaatgg ttttataatt tccatgtcaa tttttatgga aattaggctc
     6841 tttgtcaact gtagtgggtt gaagtcagct aagctcgaga aaggacaaat ttcgtccttt
     6901 cttttttgat gttcagggcg ataaaaatcc gttttttgaa
//
LOCUS       DBERMM010000068         6463 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.070, whole genome shotgun sequence.
ACCESSION   DBERMM010000068 DBERMM010000000
VERSION     DBERMM010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6463)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6463)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6463
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.070"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..743
                     /locus_tag="ACL8AS_001977"
     CDS             <1..743
                     /locus_tag="ACL8AS_001977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HGS1229776.1"
                     /translation="PSADLLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDD
                     RNYDNLEYIYRIEIERSTFLTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVS
                     SNTLIYLKALNTLSNFYSLVGREQEYEANYSHLMELYQTKNLDHQEFLFGYIRVRYNY
                     AHYLVSKEKYNEAIQEALETIELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYI
                     EARELCKIYNNPLMLMKIENYLKELDTV"
     gene            1126..1746
                     /locus_tag="ACL8AS_001978"
     CDS             1126..1746
                     /locus_tag="ACL8AS_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229777.1"
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFV
                     SGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQ
                     ELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
                     VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            1832..2275
                     /gene="tsaE"
                     /locus_tag="ACL8AS_001979"
     CDS             1832..2275
                     /gene="tsaE"
                     /locus_tag="ACL8AS_001979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HGS1229778.1"
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILIGELGAGKTTFTKGLA
                     KGLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWG
                     NLLGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            2265..2783
                     /locus_tag="ACL8AS_001980"
     CDS             2265..2783
                     /locus_tag="ACL8AS_001980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase family protein"
                     /protein_id="HGS1229779.1"
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSE
                     EMEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNG
                     LGSLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGK
                     FIDVYLMGKLID"
     gene            2791..3807
                     /locus_tag="ACL8AS_001981"
     CDS             2791..3807
                     /locus_tag="ACL8AS_001981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HGS1229780.1"
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGE
                     ETKVIEATEPLTILLMGVDTGNAERTETWVGRSDSMILMTVNPKTKKTTMMSLERDIL
                     TRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVG
                     GITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQ
                     REVIQKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQ
                     QLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVG
                     DEDN"
     gene            3892..5148
                     /locus_tag="ACL8AS_001982"
     CDS             3892..5148
                     /locus_tag="ACL8AS_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HGS1229781.1"
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGD
                     NEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIF
                     FALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
                     VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLR
                     LSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQG
                     KTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVS
                     EFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIG
                     GRSRADVRHIAVMHAFNLVRKALLSD"
     gene            5203..6369
                     /gene="recA"
                     /locus_tag="ACL8AS_001983"
     CDS             5203..6369
                     /gene="recA"
                     /locus_tag="ACL8AS_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003697 - single-stranded DNA binding
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HGS1229782.1"
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGE
                     RAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGI
                     AAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
                     ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGN
                     PETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAV
                     VEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFD
                     EIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE"
BASE COUNT         2041 a         1058 c         1462 g         1902 t
ORIGIN      
        1 ttccctccgc agaccttttg ttcaaactct cacaacgact tgaagtacca ttagattatt
       61 tttttaatga acaaattgaa attaaatcta acctctctaa tttcaagcaa ttgtctgctc
      121 gactattaga tgacagaaat tatgataatt tggaatatat ttatagaatt gagattgaac
      181 gaagtacttt tctaacacta gaagaccgaa cttatcttga atggattaaa gctattattg
      241 acttctatca atatgacagt aagtgtgagg caatttcttc attggaaaat atattattaa
      301 aagtctcttc aaatactctg atttatttaa aggcgttgaa tactctatct aatttctatt
      361 ccttagtggg tcgtgaacaa gaatatgagg caaactactc tcatttaatg gagttatatc
      421 agacaaaaaa tttggaccat caagagtttt tatttggcta catcagagtt cgttacaact
      481 acgctcacta cctagtatca aaggaaaaat ataatgaagc catccaagaa gctcttgaaa
      541 cgattgaact ctgtaaacaa agacagacaa gctaccaatt ggctcctcta cttattcttg
      601 taggaaatgc tggagccaaa tttctagaca gagaacaagt caaaaattat tatatagaag
      661 caagagagtt atgtaagatt tataacaatc ctttaatgtt gatgaagata gaaaattatt
      721 tgaaggaatt agatactgtt tagttaatct tgacattata gtttttctga aacgttaaat
      781 aacctgtaag gctgatagtt agattaatac tatcagcctt atcattatgt gactctgagt
      841 ccgtctcgct ccgtgaggtg cgagacaaaa caaccacccg tttgacggat tttcatgatt
      901 tcaaatttat attcttcgaa aatctcttca aaccacgtca gctctatctg caatctcaaa
      961 acactgtttt gagcaacctg tggctagcta cctagtttga tctttgattt tcattgagta
     1021 ttagtctcta gtgtttgttt agcgtcttaa agagacattt gagaagatta gaaacagttc
     1081 tctcttttct cctagtataa tgattggtag gaagggagag agaagatgaa atcaatgaga
     1141 atcttatttt tgttagcttt aattcaaatc agtttgagta gctgtttcct atggaaggaa
     1201 tgcatcttgt cctttaaaca aagtacagct tttttcatcg gaagcatggt tttcgtttca
     1261 ggaatctgtg ctggagtaaa ttatctttat acccgtaagc aagaagtcca tagtgtccta
     1321 gccagtaaga agtcggtgaa gcttttttac agtatgttac tcttaattaa tttgttagga
     1381 gctgttcttg ttttgtcaga taacttgttc atcaaaaata cgctgcagca agaattagtt
     1441 gactttttat tgccatcctt ctttttccta tttgggctag atttgctgat ttttttaccc
     1501 ttgaaaaaat acgtgcgcga ttttcttgct atgctagaca gaaaaaagac agtgttggtg
     1561 actattttag caacacttct tttcttaaga aatccaatga ccattgtctc acttctgatt
     1621 tatactggac tgggcttgtt ttttgcagcc tatcttgtcc caaattcggt taagaaggaa
     1681 gtttcctttt atggtcatat tttccgagat cttgtattgg tcattgttac gctcattttc
     1741 ttttagagaa agcctgtttt ttatggatgt tatgatgata agtttagtag gaaaatagac
     1801 acaaaagaaa agtttttggt ataataagag tatgtacaca aaaaatgaag aagagttgca
     1861 agccttaggg gagcgtttgg gccatctatt agcaaagaat gatgttttaa tcttaattgg
     1921 agaactgggt gcaggtaaaa cgacctttac taaaggactt gcaaaaggat tacagatttc
     1981 tcaaatgatt aaaagtccta cctatactat cgtgagagag tatgaaggtc gacttccact
     2041 ttatcaccta gatgtttatc gtattgaagg agatgctgat tctatcgact tggatgagtt
     2101 tatctttggt ggcggcgtga ctgttattga gtggggaaat ctcttaggag atgccttgcc
     2161 agatgcttat ttagaattgg aaattctaaa agaagcagat ggacgccgtt taaattttca
     2221 ggcaaagggt ttgcgtgctg agaaattgtt agaggagctt caatatggag tatgaattgc
     2281 tcattaggga agcagagccc aaagatgcag ctgaattagt ggccttttta aatcgtgtga
     2341 gtttggagac agactttacc agcctagacg gagatggtat tctcttgact agtgaggaga
     2401 tggaaatatt cctcaacaag caagctagtt cggacaatca gataacctta cttgcattct
     2461 taaatggcaa aattgctggt attgtaaata ttacagctga ccagcgtaag agagtccgtc
     2521 atattggaga tctcttcatt gtgattggaa aaagatattg gaataatggc ttgggaagtt
     2581 tgttgctaga agaagcgata gagtgggcac aagcaagtgg cattctgcgt cgtctccaac
     2641 tgactgtcca aactcgtaat caagcagcag tccatcttta tcaaaagcat ggctttgtca
     2701 ttgaaggtag ccaagagcgt ggggcatata tagaagaagg gaaatttatc gatgtttact
     2761 tgatgggtaa actgatagat tagtagaaat atggttaaaa aaattattgg aatggtgcta
     2821 gctttacttt ctgtaactgt agtaggagta ggtgtttttg cttatactat ttatcaacaa
     2881 gggacagaaa ccttagctaa aacctataaa aaaatcggcg aagaaaccaa ggttattgaa
     2941 gcgactgaac ctctaaccat tctgttaatg ggagtggaca ccggaaatgc tgaacgaact
     3001 gaaacttggg tcggtagaag tgatagcatg atcttgatga cagtgaatcc taaaacgaaa
     3061 aaaacaacaa tgatgagttt agagcgggat attctgacgc gcattgaatc agggaatggt
     3121 caggctcatg aagcgaaact gaactcagca tatgcagatg gtggagcaga gcttgctata
     3181 gaaaccattc aaaaaatgat gaatatccat attgatcgct atgtgatggt caatatgaga
     3241 gggttgcaaa aactagtgga tgcagtagga ggtattacag tcaataatat cctaggtttc
     3301 ccaatttcta tcagtgacca agaagaattt aatactattt ctatcggtgt tggggagcaa
     3361 catattgggg gagaagaagc cctagtctat gcacgaatgc gttaccaaga tcctgagggg
     3421 gattatggtc gtcaaaaacg tcaacgtgaa gttattcaaa aagtcatgga aaaagctctc
     3481 agtttaaata gcgttggtca ttatcaagag attctaaaag ctttgagtga caatatgcag
     3541 accaatattg atttgtctgc aaaaagtatc cctaacttgc taggctataa agattcattt
     3601 aaaaccattg aaactcagca gttgcagggt gaaggagaga tacttcaagg tgtttcttac
     3661 cagattgttt cgagagcaca tatgttggaa atgcaaaata tactccgacg ttctttggga
     3721 caagaagaag ttactcagct tgaaaccaat gcggttttat ttgaagattt atttggcaga
     3781 gcacctgttg gtgatgaaga taattaactt ttgatacaaa taaaaaaatc aatcgtagga
     3841 aaattcctgc gattttttca aaaaaatacg aatagatagg taggaggaaa catgaaagca
     3901 gaaatcattg ctgttggaac agagattttg acaggacaga ttgtcaacac caatgcccag
     3961 tttttgtcgg aaaaactagc tgagattggg gtagatgtat attttcagac ggctgtagga
     4021 gacaatgaag ttcgtctctt gtctttgctt gagattgcca gtcaacgtag cagtctggtg
     4081 attttgacag gcggtttggg gccaactgag gacgacctaa ccaaacaaac cctagctaaa
     4141 tttttaggga aagcattagt ctttgatcct caggctcagg agaagttgga tatctttttt
     4201 gccctgcgac cagactatgc ccgaacaccg aataacgaaa gacaagctca aattgtagaa
     4261 ggagcgattc cactgccaaa cgaaacagga ctggctgttg gaggaaaatt agaagtagac
     4321 ggagtgacct atgtcgtcct tccaggtccg ccaagtgaat tgaaacccat ggtcttaaac
     4381 caacttctac ccaagttgat gacagggaac aagctgtatt cccgagttct tcgtttcttt
     4441 gggattggcg agagccagtt ggttacgatt ttggctgatt taattgataa tcagatcgat
     4501 cctaccttgg ccccttatgc caagacagga gaagtcactc tacgtctgtc aacaaaggct
     4561 agcagtcaag aagaggcgaa tcaagcgctg gatatcttgg aaaatcaaat cttggactgc
     4621 cagactttcg aaggaatttc tttacgagac ttttgctatg gttatgggga agaaactagt
     4681 ttagccagca ttgtggtaga agaactgaaa aggcaaggga aaaccatcgc ggctgcagag
     4741 agtttgacgg caggtctttt ccaagctacc gtggcgaatt tttctggagt ttcaagtata
     4801 tttgagggtg gttttgtgac ctatagcttg gaggaaaaat caaggatgtt ggatattcct
     4861 gccaagaatt tggaagaaca tggtgtggtg tctgaattta cagctcagaa gatggctgag
     4921 caggcacgaa gcaagaccca gtctgatttt ggaattagtt tgactggagt ggcaggacca
     4981 gatagcctag aaggacaccc agttgggaca gtcttcatag gcttggcgca agatcaagga
     5041 actgaggtta tcaaggttaa tattggaggc agaagccgag cagatgtacg tcacattgcg
     5101 gttatgcatg cctttaacct agttcgcaag gctttattaa gtgactaact tttgatataa
     5161 tagtagatag gtctgaggat cattagaatg taggagaata gaatggcgaa aaaaccaaaa
     5221 aaattagaag aaatttcaaa aaaatttggg gcagaacgtg aaaaggcctt gaatgacgct
     5281 cttaaattga ttgagaaaga ctttggtaaa ggatcaatca tgcgtttggg tgaacgtgcg
     5341 gagcaaaagg tgcaagtgat gagctcaggt tctttagctc ttgacattgc ccttggctca
     5401 ggtggttatc ctaagggacg tatcatcgaa atctatggcc cagagtcatc tggtaagaca
     5461 acggttgccc ttcatgcagt tgcacaagcg caaaaagaag gtgggattgc tgcctttatc
     5521 gatgcggaac atgcccttga tccagcttat gctgcggccc ttggtgtcaa tattgacgaa
     5581 ttgctcttgt ctcaaccaga ctcaggagag caaggtcttg agattgcggg aaaattgatt
     5641 gactcaggtg cagttgatct tgtcgtagtc gactcagttg ctgcccttgt tcctcgtgcg
     5701 gaaattgatg gagatatcgg agatagccat gttggtttgc aggctcgtat gatgagccag
     5761 gccatgcgta aacttggcgc ctctatcaat aaaaccaaaa caattgccat ttttatcaac
     5821 caattgcgtg aaaaagttgg agtgatgttt ggaaatccag aaacaacacc gggcggacgt
     5881 gctttgaaat tctatgcttc agtccgcttg gatgttcgtg gtaatacaca aattaaggga
     5941 actggtgatc aaaaagaaac caatgtcggt aaagaaacta agattaaggt tgtaaaaaat
     6001 aaggtagctc caccgtttaa ggaagccgta gttgaaatta tgtacggaga aggaatttct
     6061 aagactggtg agcttttgaa gattgcaagc gatttggata ttatcaaaaa agcaggggct
     6121 tggtattctt acaaagatga aaaaattggg caaggttctg agaatgctaa gaaatacttg
     6181 gcagagcacc cagaaatctt tgatgaaatt gataagcaag tccgttctaa atttggcttg
     6241 attgatggag aagaagtttc agaacaagat actgaaaaca aaaaagatga gccaaagaaa
     6301 gaagaagcag tgaatgaaga agttccgctt gacttaggcg atgaacttga aatcgaaatt
     6361 gaagaataag ctgttaaagc agtggagaaa tccgctactt tttcgatttt tgattcaagt
     6421 ttttagatta tatatagtag cttgaaataa gatatgaaca act
//
LOCUS       DBERMM010000069         6461 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.071, whole genome shotgun sequence.
ACCESSION   DBERMM010000069 DBERMM010000000
VERSION     DBERMM010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6461)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6461)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6461
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.071"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            79..1054
                     /locus_tag="ACL8AS_001984"
                     /pseudo
     CDS             79..1054
                     /locus_tag="ACL8AS_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862469.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            1231..2238
                     /gene="gap"
                     /locus_tag="ACL8AS_001985"
     CDS             1231..2238
                     /gene="gap"
                     /locus_tag="ACL8AS_001985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HGS1229783.1"
                     /translation="MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHL
                     LKYDTTQGRFDGTVEVKEGGFEVNGKFVKVSAERDPEQIDWATDGVEIVLEATGFFAK
                     KEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
                     KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIG
                     LVIPELNGKLDGSAQRVPTPTGSVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDP
                     IVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIA
                     K"
     gene            complement(2305..3180)
                     /locus_tag="ACL8AS_001986"
     CDS             complement(2305..3180)
                     /locus_tag="ACL8AS_001986"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HGS1229784.1"
                     /translation="MQFTFTLPASLPQMTVKQLLEEQLLIPRKIRHFLRIKKHILINQ
                     EEVHWNEIVNPGDVCQLTFDEEDYSQKTIPWGNPDLVQEVYQDQHLIIVNKPEGMKTH
                     GNQPNEIALLNHVSTYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLEKKEISR
                     EYWALVDGNINRKELVFRDKIGRDRHDRRKRIVDAKNGQYAETHVSRLKQFSNKTSLA
                     RCKLKTGRTHQIRVHLSHHNLPILGDPLYNSKSKTSRLMLHAFRLSFTHPLTLEKLTF
                     TTLSNTFEKELKKNG"
     gene            3267..5462
                     /gene="pbp2a"
                     /locus_tag="ACL8AS_001987"
     CDS             3267..5462
                     /gene="pbp2a"
                     /locus_tag="ACL8AS_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP2A"
                     /protein_id="HGS1229785.1"
                     /translation="MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGP
                     IRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKE
                     AGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGS
                     TITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVE
                     DASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYI
                     DKNQETEAAEVDMASQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYR
                     IYTELDQNYQANMQVVYENTSLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDK
                     TGFRNFNYATQSKRSPGSTIKPLVVYTPAVEAGWALNKQLDNHTMQYDSYKVDNYAGI
                     KTSREVPMYQALAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGV
                     ETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIASHKNSQKRVIDKSVADKMTS
                     MMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFP
                     TTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTFTVENAYKQNGIAPANTKRQVQT
                     NDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR"
     gene            5515..5667
                     /gene="rpmG"
                     /locus_tag="ACL8AS_001988"
     CDS             5515..5667
                     /gene="rpmG"
                     /locus_tag="ACL8AS_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HGS1229786.1"
                     /translation="MALKKASLACAVCGSRNYSIKISGNPKPTRLEVNKFCKHCGKYT
                     THRETR"
     gene            5677..5853
                     /gene="secE"
                     /locus_tag="ACL8AS_001989"
     CDS             5677..5853
                     /gene="secE"
                     /locus_tag="ACL8AS_001989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA];
                     GO_process: GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HGS1229787.1"
                     /translation="MRFIGDIFRLLKDTTWPTRKESWRDFRSIMEYTAFFVVIIYIFD
                     QLIVSGLIRFINIF"
     gene            5908..6444
                     /gene="nusG"
                     /locus_tag="ACL8AS_001990"
     CDS             5908..6444
                     /gene="nusG"
                     /locus_tag="ACL8AS_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusG"
                     /protein_id="HGS1229788.1"
                     /translation="MDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIP
                     TQTVQVEKNGKRKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPT
                     PLLEQEIRDILVSMGQTVQEFDFDVEIGQTVRIIDGAFADYTGKITEIDNNKVKMIIS
                     MFGNDTVAEVNLNQIAEL"
BASE COUNT         2009 a         1129 c         1411 g         1912 t
ORIGIN      
        1 tgctcttgtt tcaattgact atagttcacg gatacagttg ggaaagaagc tattaaatat
       61 ttggagagtc cttttgggat gaacatgtca aatattacta tagatgggca agaaaagatg
      121 ggcaagaaat ggatctgagt caaacgatgc ttcttatgct caagtagtga gtctttatga
      181 tgatacaagt atctctgtta gtaataatga gacggacaaa gtgttgactg gatccctcta
      241 tactgaaaca aatgaacagg gattaacgat tccaagcagt ttactaaaaa attggaatga
      301 acagacagga aaaaatttga caactaatga tcttattggc aaatcagtct cagccagcat
      361 tgtagaaagt gctgccgaaa ctagtaagat tgctcaattt caaacgaaga ttgtacgtgt
      421 aatcaatgat gaagatgaca tggaggacag caacagtttc atgctgtctc atcaaatgga
      481 aacgattttg aaagaggctg gatttacgaa agctgtatct tattttatct tggaactcaa
      541 agatccatca cagacaaaag tagtaacaga agaattacag aaaaataaga agtatactgt
      601 gttttctcaa cagagagttc ttgatattgt gattaccttt attcgtgtta ttcagggatt
      661 attgattgtg ctttcatcac aagctattgt ggtagcagcg gttatgattg gtatcattat
      721 ttacatcaat atcatgcaac gttccaagga aataggtgtc atgaaagcag ttggttatca
      781 gaatcgtggt gtcaaaggaa tttttattta cgaggctatc tggattgtag gcatcgcctt
      841 gctgctggca tttttggttg cacaaggggt gggaagtttg gcgaatgcga ttgtaagtca
      901 cttttaccca tccatcacta aggtttttga attaaatctt ttatctgttt taggaactct
      961 agttttcgct ctattacttg gttatgtctc agcctacttc ccggcgcgta agattagtaa
     1021 aatggatcct gtagaatcgt tacgctatga ataataaggg attccttgat ttacagtctt
     1081 aaaaagaaac tcacatagaa aaacaatggc catacttgca attcaactca aatagttgta
     1141 taataggttt gttgaaaggt gatttgtagt gattcaagtt actcttttca caataaaaat
     1201 ttcatgattt tcataaggag gaaatcacta atggtagtta aagttggtat taacggtttc
     1261 ggacgtatcg gtcgtcttgc tttccgtcgt atccaaaacg tagaaggtgt tgaagttaca
     1321 cgcatcaacg accttacaga tccagttatg cttgcacact tgttgaaata cgacacaact
     1381 caaggtcgtt tcgacggtac tgttgaagtt aaagaaggtg gattcgaagt taacggtaaa
     1441 ttcgttaaag tttctgctga acgtgatcca gagcaaatcg actgggctac tgacggtgta
     1501 gaaatcgttc ttgaagctac tggtttcttt gctaagaaag aagcagctga aaaacacctt
     1561 aaaggtggag ctaaaaaagt tgttatcact gctcctggtg gaaacgacgt taaaacagtt
     1621 gtattcaaca ctaaccacga cgttcttgac ggtactgaaa cagttatctc aggtgcttca
     1681 tgtactacaa actgcttggc tccaatggct aaagctcttc aagataactt tggtgttgtt
     1741 gaaggattga tgactactat ccacgcttac actggtgacc aaatgatcct tgacggacca
     1801 caccgtggtg gtgaccttcg ccgtgctcgc gctggtgctg caaacatcgt tcctaactca
     1861 actggtgctg ctaaagctat cggtcttgta atcccagaat tgaacggtaa acttgacgga
     1921 tctgcacaac gcgttccaac tccaactgga tcagttactg aattggtagc agttcttgaa
     1981 aagaacgtta ctgttgatga agtgaacgca gctatgaaag cagcttcaaa cgaatcatac
     2041 ggttacacag aagatccaat cgtatcttca gatatcgtag gtatgtctta cggttcattg
     2101 tttgacgcaa ctcaaactaa agttcttgac gttgacggta aacaattggt taaagttgta
     2161 tcatggtacg acaacgaaat gtcatacact gcacaacttg ttcgtactct tgaatacttc
     2221 gcaaaaattg ctaaataatt cttgagttga tagaaagcaa ggctttgtgg tcttgctttt
     2281 tatatggaaa aatggatgac acgatcatcc attctttttt aattcttttt caaatgtatt
     2341 tgaaagggta gtgaaagtta gcttctctaa agtaagtggg tgggtaaagg aaagtcggaa
     2401 ggcatgaagc ataagccgac ttgtctttga tttactatta tagagagggt cgcccaggat
     2461 aggaagatta tgatgcgaaa ggtgcacacg aatctgatgg gttcgccctg tctttagctt
     2521 gcaacgagcc aaggaagtct tgtttgagaa ttgctttaac ctgcttacat gcgtttcagc
     2581 atattgccca ttttttgcat caactattct ttttctacga tcatggcgat cacgtccaat
     2641 tttgtctctg aaaacaagtt cttttctgtt gatatttcca tcaactagag cccaatattc
     2701 tctagaaatc tcttttttct ccaataagcg attgagaatg ggcaggataa aaggattttt
     2761 ggcaaagaga actaagccac tggtttccat gtccagacga tgaacgacat agcaggtttg
     2821 gccaacatag gtactgacat ggttaagaag ggcaatttcg tttggttgat taccatgcgt
     2881 tttcatcccc tctggtttgt ttacaataat caagtgttga tcttgataaa cttcctgcac
     2941 taagtctggg ttgccccaag ggatcgtctt ttgggaataa tcttcctcgt caaaagtcaa
     3001 ctggcaaaca tctccaggat ttacgatttc gttccagtgg acttcttctt gatttatcaa
     3061 aatatgtttc ttgattctca aaaaatgacg gatttttcta gggatgagga gttgttcctc
     3121 aagtaattgc tttaccgtca tttgaggtag agaggcgggt aatgtaaatg tgaattgcat
     3181 acagatattg taacaaaaaa agccctattt ggataggaaa tagctaaatt cttgtcttcc
     3241 tatgatgaag atgataaaat aaacgcatga aattagataa attatttgag aaatttcttt
     3301 ctctttttaa aaaagaaaca agtgaactag aggactctga ttctactatc ttacgtcgct
     3361 ctcgtagtga tcgaaaaaaa ttagcccaag taggtccgat tcgaaaattc tggcgtcgtt
     3421 atcatctaac aaagattatc cttatactag gtttgagtgc aggcttgcta gttggaatct
     3481 atttgtttgc tgtagccaag tcaaccaatg tcaatgattt gcaaaatgcc ttgaaaactc
     3541 gaactcttat ttttgaccgt gaagaaaaag aggctggtgc cttgtctggt caaaagggaa
     3601 cctatgttga gctgactgac atcagtaaaa acttgcagaa tgctgttatt gcgacagaag
     3661 accgttcttt ctataaaaat gacgggatta actatggccg tttcttcttg gctattgtca
     3721 ctgctggccg ttcaggtggt ggatctacca ttacccaaca gctggctaaa aacgcctatt
     3781 tatcgcagga tcaaactgtt gagagaaaag cgaaagaatt tttccttgcc ttagaattaa
     3841 gcaaaaaata tagtaaggag caaattctaa ccatgtacct taacaacgct tattttggaa
     3901 atggtgtgtg gggtgtagaa gatgcgagta agaaatactt tggagtttct gcatcagaag
     3961 tgagtctgga tcaagctgcg actctggcag ggatgctcaa ggggccggaa ctgtataatc
     4021 ccttgaattc cgtagaagat tctactaatc ggcgcgatac tgtcttgcag aatatggttg
     4081 cagcaggata tattgataaa aaccaagaaa ccgaagctgc tgaagttgat atggcttcgc
     4141 aattgcacga taagtatgaa ggaaaaatct cagattaccg ttacccctct tattttgatg
     4201 cggtggttaa tgaagctgtt tccaagtata atctaacaga ggaagagatt gtcaataatg
     4261 gctaccgcat ttacacagag ctggaccaaa actaccaagc aaatatgcag gttgtttatg
     4321 aaaacacatc gctatttccg agggcagagg atggaacgtt tgctcaatca ggaagtgtag
     4381 ctctcgaacc gaaaacaggg ggagttcgtg gagttgtcgg tcaagttgct gacaatgata
     4441 aaactggatt ccggaatttc aactatgcaa cccaatcaaa gcgtagtcct ggttctacaa
     4501 ttaagccttt agttgtttat acgccagcag ttgaagcagg ctgggctttg aataagcagt
     4561 tggataacca taccatgcag tatgacagct ataaggttga taactatgca gggatcaaaa
     4621 cgagtcgaga agttcctatg tatcaagcct tggcagaatc gcttaatcta cctgctgttg
     4681 ccactgttaa tgatttgggt gtcgacaagg cttttgaggc aggcgaaaaa ttcggactca
     4741 acatggaaaa ggtcgaccgt gttcttggtg tcgccttggg aagcggtgtt gaaaccaacc
     4801 ctcttcaaat ggctcaagca tacgccgcct ttgcaaatga aggtttaatg cctgaagctc
     4861 attttattag tagaattgaa aatgctagtg gacaagttat tgcgagtcat aaaaattcac
     4921 aaaaacgggt gattgataag tctgtagctg acaagatgac cagtatgatg ttggggactt
     4981 tcaccaacgg taccggtatt agttcatcgc ctgcagacta tgtcatggca gggaaaactg
     5041 gaacaactga agcagttttc aatccggagt acacaagtga ccagtgggta attggttata
     5101 ctccggatgt agtgattagc cactggcttg gctttccgac cactgatgaa aaccattatc
     5161 tagctggctc tacttcaaac ggtgcagctc atgtctttag aaacattgcc aataccattt
     5221 taccttatac gccaggaagt acctttacgg ttgaaaatgc ttataagcaa aatggaattg
     5281 caccagccaa tacaaaaaga caagtacaaa ccaatgataa tagccagaca gatgataatt
     5341 tgtctgatat tcgagggcgt gcgcaaagtc tagtagatga ggctagccgg gctatctcag
     5401 atgcgaagat taaggaaaag gctcaaacaa tatgggattc gatagtcaat ctatttcgct
     5461 aagatgcttg tcaaagccta gctttcttgt tataatggat aagatggagg cgttatggca
     5521 ctaaaaaaag caagcctagc ttgtgcggtt tgtggttcga gaaactattc aatcaagatc
     5581 agcggaaacc ccaagcctac acgactagaa gtaaataaat tttgtaagca ttgtggcaag
     5641 tacactacac acagagaaac gagataggag agagcgatgc gttttattgg agatattttt
     5701 agacttctta aagacacaac atggccaact cgcaaggaaa gctggagaga ttttcgttct
     5761 atcatggaat acacagcttt ctttgtagta attatttaca tttttgacca gttgattgtt
     5821 tcaggtttga ttcgatttat taacattttt tagaagatta gtggagttaa ttacactaga
     5881 aatcttctat ttatgaaagg aaatatcatg gatagttttg ataaagggtg gtttgtttta
     5941 caaacttatt ctggttatga aaataaggtg aaagaaaatc tattacaacg tgcacaaacc
     6001 tacaatatgt tggataatat tctacgcgtt gaaattccaa cacaaacagt gcaagttgaa
     6061 aaaaatggaa agagaaaaga agtagaagaa aatcgctttc caggttatgt tcttgtagaa
     6121 atggtcatga cagatgaagc ttggtttgtt gttcgaaaca caccaaatgt tacaggattt
     6181 gtcggatcac acgggaacag atcaaaacca actccattat tggaacaaga aattcgcgac
     6241 attttggtat ctatgggaca aactgttcaa gaatttgatt tcgatgttga gattggtcaa
     6301 actgtacgta ttattgatgg tgcttttgca gactacactg gtaagattac agaaattgat
     6361 aataacaaag tgaaaatgat tatctctatg tttggtaatg acacagttgc agaagtaaat
     6421 ctaaaccaaa tcgcagaatt ataaccctga gagaggctgg a
//
LOCUS       DBERMM010000070         5978 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.072, whole genome shotgun sequence.
ACCESSION   DBERMM010000070 DBERMM010000000
VERSION     DBERMM010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5978)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5978)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5978
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.072"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            122..3223
                     /locus_tag="ACL8AS_001991"
     CDS             122..3223
                     /locus_tag="ACL8AS_001991"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000561528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HGS1229789.1"
                     /translation="MIAQLDTKTVYSFMESVISIEKYVRAAKEYGYTHLAMMDIDNLY
                     GAFDFLEITKKYGIHPLLGLEMTVFVDDQEVNLRFLALSSVGYQQLMKLSTAKMQGEK
                     TWSVLSQYLEDIAVIVPYFDRVESLELGCDYYIGVYPETLASEFHHPILPLYRVNAFE
                     SRDREVLQVLTAIKENLPLREVPLRSRQDVFISASSLEKLFQERFPQALDNLEKLISG
                     ISYDLDTSLKLPRFNPARPAVEELRERAELGLVQKGLTSKEYQDRLDQELSVIHDMGF
                     DDYFLVVWDLLRFGRSNGYYMGMGRGSAVGSLVSYALDITGIDPVEKNLIFERFLNRE
                     RYTMPDIDIDIPDIYRPDFIRYVGNKYGSKHAAQIVTFSTFGAKQALRDVLKRFGVPE
                     YELSAITKKISFRDNLKSAYEGNLQFRQQINSKLEYQKAFEIACKIEGYPRQTSVHAA
                     GVVISDQDLTNYIPLKYGDEIPLTQYDAHGVEASGLLKMDFLGLRNLTFVQKMQELLA
                     ETEGIHLKIEEIDLEDKETLALFASGNTKGIFQFEQPGAIRLLKRVQPVCFEDVVATT
                     SLNRPGASDYINNFVARKHGQEEVTVLDPVLEDILAPTYGIMLYQEQVMQVAQRFAGF
                     SLGKADILRRAMGKKDASAMHEMRASFIQGSLEAGHTVEKAEQVFDVMEKFAGYGFNR
                     SHAYAYSALAFQLAYFKTHYPAIFYQIMLNSANSDYLIDALEAGFEVAPLSINTIPYH
                     DKIANKAIYLGLKSIKGVSNDLALWIIEHRPYSNIEDFIAKLPENYLKLPLLEPLVKV
                     GLFDSFEKNRQKVFNNLANLFEFVKELGSLFGDAIYSWQESEDWTEQEKFYMEQELLG
                     IGVSKHPLQAIASKAIYPITPIGNLSENSYAIILVEVQKIKVIRTKKGENMAFLQADD
                     SKKKLDVTLFSDLYRQVGQEIKEGAFYYVKGKIQSRDGRLQMIAQEIREAVAERFWIQ
                     VKNHESDQEISRILEQFKGPIPVIIRYEEEQKTIVSPHHFVAKSNELEEKLNEIVMKT
                     IYR"
     gene            3306..4313
                     /gene="pfkA"
                     /locus_tag="ACL8AS_001992"
     CDS             3306..4313
                     /gene="pfkA"
                     /locus_tag="ACL8AS_001992"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HGS1229790.1"
                     /translation="MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGM
                     VAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGG
                     DGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSH
                     RRTFVIEVMGRNAGDIALWAGIATGADEIIIPEADFKMEDIVASIKAGYECGKKHNII
                     VLAEGVMSAAEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVQLL
                     KEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSL
                     S"
     gene            4372..5877
                     /gene="pyk"
                     /locus_tag="ACL8AS_001993"
     CDS             4372..5877
                     /gene="pyk"
                     /locus_tag="ACL8AS_001993"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0004743 - pyruvate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0030955 - potassium ion binding [Evidence
                     IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HGS1229791.1"
                     /translation="MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAK
                     LIEAGANTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFEGE
                     AKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVLVDDGKLGLRV
                     VAKDDETREFEVEVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIA
                     ISFVRTAKDVNEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG
                     IEVPFEMVPVYQKMIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGT
                     DATMLSGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVK
                     DATSSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
                     APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTVR"
BASE COUNT         1857 a         1036 c         1355 g         1730 t
ORIGIN      
        1 gatgacaaaa atacaaatga atagaaaata aattagtaag ctgatgaaat ttttctcaag
       61 agaagccatt tataggtgaa aatggtataa tatagtgaga aggatagagg agaagtgtaa
      121 attgatcgca caactagata caaaaacagt ctatagtttt atggaaagcg tcatttcgat
      181 cgaaaagtat gtgagagcag ctaaagaata cggctacact catttggcta tgatggatat
      241 tgacaatctt tatggcgctt tcgactttct agagattaca aaaaaatacg gcattcatcc
      301 tttgctaggg cttgaaatga cagtgtttgt agatgatcag gaagtgaatt tgcgcttttt
      361 agctctatct agtgtgggct atcagcagtt gatgaagctt tcgacagcca agatgcaggg
      421 ggagaaaact tggtcagtcc tgtcccagta cctggaggat atcgcggtca ttgtgcctta
      481 ttttgataga gttgagtcgt tagaactagg ctgtgattac tatatagggg tttatccaga
      541 aacactagca agcgaatttc atcatcctat cttacctctt tatcgggtca acgcttttga
      601 aagcagggat agagaagttc ttcaagtttt aacagcgatt aaagaaaatc taccgctcag
      661 agaagttccc ttgcgttcga gacaagatgt ctttatatca gcaagttctt tagagaaact
      721 attccaagag cgttttccgc aagctttgga caatttagaa aagcttattt caggcatttc
      781 ttacgacttg gatactagtc tgaaactgcc tcgttttaat ccagctagac cagcagtaga
      841 ggagttgaga gagcgtgctg aactggggct tgttcagaag gggttgacta gtaaagaata
      901 tcaagataga ctagaccaag aattgtctgt tattcatgat atgggctttg atgattattt
      961 cttggttgtt tgggatttgt tgcgttttgg acgatcgaat ggctattata tgggaatggg
     1021 aaggggttct gcagtaggca gtttggtttc ttatgcctta gacatcacgg ggattgaccc
     1081 agtagagaaa aatctgattt ttgaacgctt tcttaatcgt gaacgctata ccatgccaga
     1141 tattgatatt gatatcccag atatttatcg tccagatttt atcagatatg ttggtaataa
     1201 atatggtagt aaacatgcgg cacaaatcgt tactttttca acctttggag ccaagcaagc
     1261 tctacgagat gtcttgaaac gctttggtgt tcctgagtat gaattatctg caattactaa
     1321 gaaaatcagt tttcgtgaca atcttaagtc ggcctatgag ggaaatctcc agtttcgtca
     1381 gcaaatcaat agtaagttag aataccaaaa agcttttgag attgcttgca agatagaggg
     1441 ctatccaagg caaacctctg tccatgcggc tggtgttgta attagtgacc aagatttaac
     1501 caactacatt cctctaaagt atggtgatga aattccactg actcagtatg atgctcatgg
     1561 agttgaggct agcggacttt tgaagatgga ctttctggga ctacgaaatt tgacctttgt
     1621 tcagaagatg caagagttgc ttgctgaaac agaaggtatt catctgaaaa ttgaagaaat
     1681 cgatttagaa gacaaagaaa cgttagcttt atttgcctct ggtaatacaa aaggtatctt
     1741 tcaatttgag caaccaggtg ccattcgtct gcttaagcgt gtgcaaccag tctgttttga
     1801 agatgtcgtc gcgactactt ctctaaatcg accgggtgct agtgactata tcaataattt
     1861 tgtggcaaga aagcatgggc aggaagaagt gactgttctg gatccagtac tggaggatat
     1921 tttggctcca acctacggca taatgctcta tcaggagcag gttatgcagg ttgcccagcg
     1981 atttgccgga tttagtcttg ggaaggccga tattttgcgt cgggctatgg ggaaaaagga
     2041 tgcctctgcc atgcatgaga tgagggcttc ctttattcaa ggttcattag aagctggtca
     2101 tactgtggaa aaagcagagc aggtctttga tgttatggag aagtttgcag gctatggttt
     2161 taacaggtca cacgcctatg cctactcagc cttggccttc cagttggctt attttaaaac
     2221 acattatcca gccatatttt atcagattat gttaaattct gccaacagtg attacttaat
     2281 agatgcactt gaagcaggtt ttgaagtggc gcctctgtcc atcaacacga ttccctatca
     2341 cgataaaatt gccaacaagg ccatctatct aggtttgaaa tccattaaag gagtcagtaa
     2401 tgatttagct ctctggatta ttgaacatag accttattct aatattgaag attttatagc
     2461 taaattacct gagaattatc tgaaacttcc tctgctagaa cctttggtaa aagttggtct
     2521 tttcgattca tttgaaaaaa atcgtcaaaa agtatttaat aacttagcta atctatttga
     2581 atttgtgaaa gagttgggaa gtttgtttgg agatgctatt tatagttggc aggaatcgga
     2641 agattggacg gaacaagaaa aattttatat ggaacaagag cttttaggga taggtgtcag
     2701 caaacatcca ctacaagcta ttgcaagtaa ggctatttac ccgattaccc caatcggaaa
     2761 tttgtcagaa aatagctatg ctattatttt ggttgaagtt cagaaaataa aagtgattcg
     2821 taccaaaaag ggtgaaaata tggccttctt acaggcagat gatagtaaga aaaaattgga
     2881 tgtcactctc ttttcagact tatatcgtca ggttggacag gaaataaaag agggagcctt
     2941 ctactatgta aaaggaaaaa tacaatcacg tgatggccgt ctgcaaatga ttgcacaaga
     3001 aataagagaa gcagttgctg aacgcttttg gatacaggtg aaaaatcatg aatcggatca
     3061 agaaatttca cgtattttag aacaatttaa aggcccaatc ccagtcatca tccggtatga
     3121 agaggaacag aaaaccatcg tttctcccca tcattttgta gctaaatcca atgaattaga
     3181 ggagaaattg aatgaaatcg ttatgaaaac gatttatcgc taaaaatacg gaaaatagaa
     3241 gaattttaaa atcaaatgtg atataatcaa gaagaatgtt aaaagaaaaa ggagcataaa
     3301 ccaatatgaa acgtattgct gttttgacta gtggcggaga cgcacctggt atgaacgctg
     3361 ctatccgtgc agttgttcgt caagcaattt cagaaggaat ggaagtgttt ggtatctatg
     3421 acggatatgc tggtatggtt gccggtgaaa ttcatcccct agatgcagct tcagtaggag
     3481 acatcatttc tcgtggtggt acttttcttc actcagctcg ttatccagag ttcgctcaac
     3541 ttgaagggca acttaaaggg attgagcaat tgaaaaaaca cggaattgaa ggtgtagttg
     3601 ttatcggtgg tgacggttct taccacggcg ctatgcgttt gactgaacat ggcttcccag
     3661 ctattggtct tccaggtaca atcgataacg atatcgttgg tactgacttt acaatcggtt
     3721 ttgacacagc ggttactact gccatggacg ctattgataa gattcgtgat acatcatcaa
     3781 gtcaccgtcg tacttttgta atcgaagtta tgggacgtaa cgctggtgat atcgctcttt
     3841 gggctggtat tgcaactggt gctgatgaaa tcatcatccc tgaagcagac ttcaagatgg
     3901 aagatatcgt agcaagcatc aaagctggtt atgaatgtgg taaaaaacac aatatcatcg
     3961 tcttagctga aggtgtgatg tcagcggctg aatttggtca aaaacttaaa gaagctggag
     4021 atacaagcga ccttcgtgta acagaacttg gacatattca acgtggtggt tctccaactg
     4081 cgcgtgaccg tgttttggcg tcacgtatgg gtgcacatgc tgttcaactt cttaaagaag
     4141 gtatcggtgg tgttgcggtt ggtattcgta acgaaaaaat ggttgaaaat ccaattcttg
     4201 gtactgcaga agaaggggca ttgtttagcc ttactgcaga aggtaagatt gtggttaaca
     4261 acccacacaa agccgatatt gagctatcta gcttgaataa gagcttgtca taatttacaa
     4321 tttagttaat aagaccaaaa aggtcatata tataaaggag tcacaaaaat catgaacaaa
     4381 cgtgtaaaaa tcgttgcaac tttgggtcct gcggtagaaa tccgtggtgg taaaaaattc
     4441 ggtgaggacg gatactgggg tgaaaaactt gatgttgaag cttcagctaa aaacattgct
     4501 aaattgattg aagctggtgc taacacattc cgattcaact tctcacacgg cgaccaccaa
     4561 gaacaaggtg agcgtatggc aactgttaaa cttgcggaaa aaattgcagg taaaaaagtt
     4621 ggtttccttc ttgatacaaa aggacctgaa atccgtacag aattgttcga aggtgaagct
     4681 aaagaatatt catacaaaac tggtgaaaaa attcgtgttg caactaaaca aggaatcaaa
     4741 tcaactcgtg aagtgattgc gttgaacgtt gctggtgctc ttgatatcta tgatgatgtt
     4801 gaagttggtc gtcaagtttt ggttgacgat ggtaaacttg gtcttcgtgt ggttgctaaa
     4861 gatgatgaaa ctcgtgaatt tgaagttgaa gttgaaaacg atggtatcat cgctaaacaa
     4921 aaaggtgtga acatccctaa cactaaaatt cctttcccag ctcttgctga acgcgataac
     4981 gacgatatcc gtttcggtct tgaacaaggt atcaacttca tcgcaatttc attcgtacgt
     5041 actgcaaaag atgtgaacga agttcgtgca atctgtgaag aaactggaaa cggacatgtt
     5101 caattgttcg ctaaaatcga aaaccaacaa ggtatcgata acttagacga aatcatcgaa
     5161 gcagctgatg gtattatgat tgctcgtggt gatatgggta tcgaagtacc gttcgaaatg
     5221 gttccagttt atcaaaaaat gattatcaag aaagtcaatg ctgcaggtaa agttgttatc
     5281 actgcaacaa acatgcttga aacaatgact gaaaaaccac gtgcaactcg ttcagaagta
     5341 tcagacgtat tcaacgctgt tatcgacgga actgacgcta caatgctgtc aggcgagtct
     5401 gcaaacggta aatacccact cgagtcagta actacaatgg ctacaatcga caagaacgct
     5461 caagctcttc ttaatgaata cggacgtctt gattcagatt catttgagcg taactctaag
     5521 acagaagtaa tggcttctgc tgttaaagat gctactagct caatggatat caaattggtt
     5581 gtaactctta ctaagacagg tcatactgca cgtttgattt ctaaataccg tccaaatgct
     5641 gacatcttag cattgacatt tgacgaattg acagaacgtg gcttgatgtt gaactggggt
     5701 gttatcccaa tgttgacaga tgctccatct tcaactgacg atatgttcga aatcgctgaa
     5761 cgtaaagcgg tagaagcagg tctcgttgag tcaggcgatg atatcgttat cgttgctggt
     5821 gtgccagtag gagaagctgt tcgcacaaac acaatgcgta tccgcacagt acgttaagaa
     5881 aaatataaaa acctatcata tccagctttc tagtctgtat gatgggctct ttttttgtcc
     5941 aggggggcaa aaagggggca aaactttcat aatggatt
//
LOCUS       DBERMM010000071         5921 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.073, whole genome shotgun sequence.
ACCESSION   DBERMM010000071 DBERMM010000000
VERSION     DBERMM010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5921)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5921)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5921
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.073"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            1..185
                     /locus_tag="ACL8AS_001994"
                     /pseudo
     CDS             1..185
                     /locus_tag="ACL8AS_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            340..540
                     /locus_tag="ACL8AS_001995"
     CDS             340..540
                     /locus_tag="ACL8AS_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000226586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229792.1"
                     /translation="MVVSASASSTSPQAQEQVDKSELRALSQELDQHLKALATVSDPK
                     IDATKAVLLDAQKAPEDSALTE"
     gene            565..981
                     /locus_tag="ACL8AS_001996"
     CDS             565..981
                     /locus_tag="ACL8AS_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229793.1"
                     /translation="MKAALDSLKDVKANASDSKPAQDKKDAKQGTEDSKDSDKMTETN
                     SVPAGVIVVSLLALLGVIAFWLIRHKKESEIQQLSTELIKVLGQLDAEKADKKVLAKA
                     QNLLQETLDFVKEENGSAETETKLVEELKAILDKLK"
     gene            1212..1919
                     /gene="ccdA2"
                     /locus_tag="ACL8AS_001997"
     CDS             1212..1919
                     /gene="ccdA2"
                     /locus_tag="ACL8AS_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004237834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HGS1229794.1"
                     /translation="METIVFLISVFLAGVLSFFSPCIFPLLPVYAGILLDDQESAKSF
                     SLFGRKVLWSGLIRTLCFIAGISLIFFILGFGAGYFGHILYANWFRYGMGAIIIILGL
                     HQMEIFHLKKLEVQKSFTFKKSDSNRYWSAFLLGITFSFGWTPCIGPVLSSVLALAAS
                     GGNGAWQGAIYTLIYTLGMALPFLVLALASGLVMPYFSKIKRHMMLLKKIGGFLIVLM
                     GILLLLGQVNVLAGIFE"
     gene            1930..2487
                     /gene="sdbB"
                     /locus_tag="ACL8AS_001998"
     CDS             1930..2487
                     /gene="sdbB"
                     /locus_tag="ACL8AS_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     lipoprotein SdbB"
                     /protein_id="HGS1229795.1"
                     /translation="MKKVMFAGLSLLSLVVLMACGQEETKKTQAAQQPKQQTTVQQIS
                     VGKDAPDFTLQSMDGKEVKLSDFKGKKVYLKFWASWCGPCKKSMPELMELAAKPDRDF
                     EILTVIAPGIQGEKTVEQFPQWFQEQGYKDIPVLYDTKATTFQAYQIRSIPTEYLIDS
                     QGKIGKIQFGAISNADAEAAFKEMN"
     gene            2861..4252
                     /locus_tag="ACL8AS_001999"
     CDS             2861..4252
                     /locus_tag="ACL8AS_001999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="APC family permease"
                     /protein_id="HGS1229796.1"
                     /translation="MNIFRTKNVSLDKTEMHRHLKLWDLILLGIGAMVGTGVFTITGT
                     AAATLAGPALVISIVISALCVGLSALFFAEFASRVPATGGAYSYLYAILGEFPAWLAG
                     WLTMMEFMTAISGVASGWAAYFKGLLSQYGIAFPQALNGTFNPQAGTFVDLLPILVLV
                     LVTSLVLLNAKAALRFNSILVILKFSALALFVLVGIWNIKFDNWSNFAPYGFGQIYGA
                     STGIMAGASLMFFGFLGFESISMAVDEVKTPQKNIPRGIVLSLSIVTILYALVTLVLT
                     GVVHYSHLNVDDAVAFALRSVGISWAANYVSLVAILTLITVCISMTYALSRMIYSLAR
                     DGLVPAAFKELTKTSKIPKNATILTGLASAVAAGMFPLASIAAFLNICTLAYLIMLAY
                     GLIRLRKEKGMPKAGEFKTPLVPLLPILSIIICLSFMLQYNMNTWIAFLVALLVGSII
                     YFTYGYKHSTIEE"
     gene            4395..5312
                     /gene="adcAII"
                     /locus_tag="ACL8AS_002000"
     CDS             4395..5312
                     /gene="adcAII"
                     /locus_tag="ACL8AS_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding lipoprotein AdcAII"
                     /protein_id="HGS1229797.1"
                     /translation="MKKQNLFLVLLSVFLLCLGACGQKESQTGKGMKIVTSFYPIYAM
                     VKEVSGDLNDVRMIQSSSGIHSFEPSANDIAAIYDADVFVYHSHTLESWAGSLDPNLK
                     KSKVKVLEASEGMTLERVPGLEDVEAGDGVDEKTLYDPHTWLDPEKAGEEAQIIADKL
                     SEVDSEHKETYQKNAQAFIKKAQELTKKFQPKFEKATQKTFVTQHTAFSYLAKRFGLN
                     QLGIAGISPEQEPSPRQLTEIQEFVKTYKVKTIFTESNASSKVAETLVKSTGVGLKTL
                     NPLEADPQNDKTYLENLEENMSVLAEELK"
     gene            5320..>5921
                     /locus_tag="ACL8AS_002001"
     CDS             5320..>5921
                     /locus_tag="ACL8AS_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HGS1229798.1"
                     /translation="MKINKKYVAGSVAVLALSVCSYELGRYQAGQDKKESNRVAYIDG
                     DQAGQKAENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISE
                     ELLMKDPNYQLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIKRQKQER
                     SHNHNSRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDA"
BASE COUNT         1814 a         1045 c         1264 g         1798 t
ORIGIN      
        1 gaggcaaagt atctggaaga agatatcaga ggatttcttt ggttgcaggt ctaacaaatg
       61 gtgaattaat cgctccaatg acttacgaag agacgatgac gagcgacttt tttgaagctt
      121 ggtttcagaa atttctctta ccaacattaa ccacaccatc ggttattata ttaaaacgaa
      181 ataagaatag gacaaatcga tcaggacagt aaaatcgaat tctaacaatg ttttagaagt
      241 ccatatgtac tattctagtt tcaatatacc ataactgctc ctagtcaacc tgcaagtcct
      301 gtcccagatc caagctcagc tccgactcaa gatcctagag tggtagtaag cgcttcggct
      361 agctcaacga gcccacaagc tcaagagcaa gttgacaagt ctgaacttcg tgccttgagt
      421 caagagttag accaacactt gaaagctttg gcaacagtat ctgatccgaa aatcgatgca
      481 accaaggctg tcctcctaga tgctcaaaaa gctccggaag atagtgcctt gacagagtaa
      541 ggtctgcata ctgcagtaga gtctgtgaag gctgccttgg actctctcaa agatgtgaaa
      601 gcaaatgcta gcgacagcaa gcctgcacag gacaagaagg atgcaaaaca aggaacggaa
      661 gatagtaagg attcagataa gatgactgaa acaaactcag ttccggcagg agtgattgtg
      721 gtcagtctac ttgccctcct aggcgtgatt gccttctggc tgattcgcca taagaaagag
      781 tcagaaatcc agcaattaag cacggaatta atcaaggttc taggacagct agatgcagaa
      841 aaagcggata aaaaagtcct tgccaaagcc caaaaccttc tccaagaaac ccttgatttc
      901 gtgaaagaag aaaatggctc agcagagaca gaaactaaac tagtagagga gcttaaagca
      961 atccttgaca aactcaagta aaacatgatt tatgaaatgt cagacttaaa agacattttc
     1021 gttcacaaaa gcagcgacga gtaatccttg tcgttgcttt ttggctattt tgggggataa
     1081 gatccgcctt gactagcaaa agaaaagatt ggtccaatag tgcccgatac gattttgcgt
     1141 agcagaaagc ttacaaataa aattgaatat agtaaaatag gattagaatt attaagaaag
     1201 ttggttcttt attggaaacg atagtatttt taatctctgt ttttctagca ggtgttttat
     1261 cctttttttc tccttgtatt tttcctcttc tgccagtcta tgctgggatt ttattggatg
     1321 atcaagaaag tgcaaaaagc ttttctttgt ttgggagaaa ggttctctgg tcaggcttga
     1381 ttcgaacact ttgctttatc gctggtatct ctctcatttt ctttattcta ggctttggtg
     1441 ctggttactt tggtcatatt ctctatgcaa attggtttcg atatggcatg ggagctatta
     1501 ttatcatttt gggtcttcac cagatggaaa tttttcattt gaagaaatta gaagttcaaa
     1561 aaagttttac ctttaaaaaa tcagattcta atcgttattg gtcagctttt ttacttggta
     1621 ttacctttag ctttggttgg acaccttgta ttggtccagt tttaagttct gttttagcac
     1681 ttgcggcttc tggaggcaat ggcgcttggc aaggagcgat ttatactctc atttacactc
     1741 tgggcatggc ccttcctttc ttggtattgg cactagcttc aggtctagtc atgccatatt
     1801 ttagtaaaat caagcgtcat atgatgctac taaagaaaat tggtggtttc ctcattgttt
     1861 taatgggaat tttgttacta ttaggacaag taaatgttct agctggaatt tttgaataaa
     1921 ggaggacaaa tgaaaaaagt aatgtttgct ggcttaagtc tcttgtcatt agttgtattg
     1981 atggcctgtg gtcaggaaga aactaaaaag actcaagcag cacaacagcc aaaacaacaa
     2041 acgactgtac aacaaatttc tgttggaaaa gatgctccag actttacatt gcaatccatg
     2101 gatggcaaag aagttaagtt atctgatttt aagggtaaaa aggtttactt gaagttttgg
     2161 gcttcatggt gtggtccatg caagaaaagt atgccagagt tgatggaact agcggcgaaa
     2221 ccagatcgtg atttcgaaat tcttactgtc attgcaccag gaattcaagg tgaaaaaact
     2281 gttgagcaat tcccacaatg gttccaggaa caaggatata aggatatccc agttctttat
     2341 gataccaaag caaccacctt ccaagcttat caaattcgaa gcattcctac agaatattta
     2401 attgatagcc aaggaaagat tggaaagatt caatttggtg ctatcagtaa tgcggatgca
     2461 gaagcagcat ttaaagaaat gaactagaat cgataaaatc tgattacaag atgtagtcag
     2521 attttggtaa cttctaaaac taacttccag tttcccacaa cttagctttt agtatgagaa
     2581 aaacgcgtga catcagtgga aatccgtctt agactaactt tcactggttt tctttttctt
     2641 gatatataag ggttcaaaag cgaaaagact cagaaaaagt gcacgacaaa tagccctaaa
     2701 acagagtcgt cttagagtaa cttccagttt tgggagagag atggaagtta ctttgagaag
     2761 ttacggtagt cagatttttt tagaaaaaca ttttataaat attcacatat ctcctatatt
     2821 tatggtaaaa tagaattatc agtttatttt ggagtcaaag atgaatatat ttagaacaaa
     2881 gaatgttagt ttagataaaa cagagatgca taggcatttg aagttatggg atttgatttt
     2941 gctgggtatc ggagccatgg tagggacagg cgtctttaca atcacaggta ctgcagctgc
     3001 aacacttgct ggcccagccc tagtgatttc aatcgttatt tctgccttgt gtgtgggatt
     3061 atcagccctc ttttttgcag aatttgcctc gcgagtaccc gctacaggag gtgcctatag
     3121 ttacctctat gctatcttag gagaattccc tgcctggttg gctggttggt taaccatgat
     3181 ggagttcatg acagccatat caggcgtagc ttcgggttgg gcagcttatt ttaaaggctt
     3241 gctctctcaa tacgggatag cctttcctca ggctttaaat ggtaccttta atcctcaagc
     3301 agggacattt gttgatttat tgcctattct tgtcttggtc ttggtgactt cgcttgtttt
     3361 actaaatgcc aaggcagcct tacgctttaa ttcgattcta gttattttga aattttccgc
     3421 tttagctctc tttgttttag taggaatttg gaatattaag tttgataatt ggagcaattt
     3481 tgctccttac ggttttggac aaatctatgg agctagcact ggtattatgg ctggtgcgtc
     3541 cttgatgttc ttcggttttt tgggatttga atccatctct atggctgtag atgaagtcaa
     3601 gactcctcaa aaaaatattc ctagagggat tgtcttatcg ctttctatcg taaccattct
     3661 ctatgccttg gtgacccttg ttttgactgg tgtggttcac tatagtcatt taaatgtcga
     3721 tgatgccgtt gcctttgccc ttcgtagtgt tgggattagt tgggcagcca actatgtgtc
     3781 attagtggct atcttgacct tgattacagt ttgtatttcg atgacctatg ccctatcgcg
     3841 tatgatttac agtttagcac gtgacggctt agtgcctgct gcctttaagg aactgacgaa
     3901 gactagcaag ataccaaaga atgctactat cttgacaggt ctagcttcag cagtagcagc
     3961 aggaatgttc ccactagcca gtattgcagc ctttttaaat atttgtacct tagcctactt
     4021 gatcatgttg gcttatggtc tgattcgctt acggaaagaa aaaggaatgc ccaaagctgg
     4081 ggaatttaaa acaccattgg tacctctgtt accaatttta tcgatcatca tttgtttatc
     4141 cttcatgtta cagtataata tgaacacctg gattgctttc ctagttgcgt tgttagtagg
     4201 aagtattatt tacttcactt atggctataa gcattctacc atagaagaat aaagtgaaag
     4261 tctattgagt tgttgacact cagtagattt ttatatgtga aagaaatttc aaattttttc
     4321 taaaaatatc ttgacagatt aaattttcag gagtagaata tttactagtt aattaaatgg
     4381 ttaaggagtt gttcatgaag aaacaaaatt tatttttagt cctgttaagt gtctttcttt
     4441 tgtgcttggg ggcttgtggt caaaaggaaa gtcagacagg aaaggggatg aaaattgtga
     4501 ccagttttta tcctatctac gctatggtta aggaagtatc tggtgacttg aatgatgttc
     4561 ggatgattca gtcaagtagt gggattcact cctttgaacc ttcggcaaat gatatcgcag
     4621 ccatctatga tgcagatgtc tttgtttacc attctcatac actcgaatct tgggcaggaa
     4681 gtctggatcc aaatctaaaa aaatccaaag tgaaggtctt agaggcttct gagggaatga
     4741 ccttggaacg tgtccctgga ctagaggatg tggaagcagg ggatggagtt gatgaaaaaa
     4801 cgctctatga ccctcacaca tggctagatc ctgaaaaagc tggagaagaa gcccaaatta
     4861 tcgctgataa actttcagag gtggatagtg agcataaaga gacttatcaa aaaaatgcgc
     4921 aagcctttat caaaaaagct caggaattga ctaagaaatt ccaaccaaaa tttgaaaaag
     4981 cgactcagaa aacatttgta acacaacata cagccttttc ttatctagcg aagagatttg
     5041 ggcttaatca acttggtatt gcaggtatct ctcctgaaca agaaccaagt ccacgacaac
     5101 taacagaaat tcaggaattt gttaaaacct ataaggttaa aacgattttt acagaaagta
     5161 atgcttcttc aaaagtagct gaaactcttg tcaaatcaac aggtgtgggt cttaaaactc
     5221 tgaatccttt agaggcagac ccacaaaatg acaagaccta tttagaaaat ctggaagaaa
     5281 atatgagtgt tctagcagaa gaattaaagt gaggaaagaa tgaaaatcaa taaaaaatat
     5341 gtagcaggtt cagtggcagt tcttgcccta agtgtttgtt cctatgaact tgggcgttac
     5401 caagctggtc aggataagaa agagtctaat cgagttgctt atatagatgg tgatcaggct
     5461 ggtcaaaagg cagaaaattt gacaccagat gaagtcagta agagggaggg gatcaacgcc
     5521 gaacaaattg ttatcaagat tacggatcaa ggttatgtga cctctcatgg agaccattat
     5581 cattactata atggcaaggt tccttatgat gccatcatca gtgaagagct cctcatgaaa
     5641 gatccgaatt atcagttgaa ggattcagac attgtcaatg aaatcaaggg tggttatgtc
     5701 attaaggtaa acggtaaata ctatgtttac cttaaggatg cagctcatgc ggataatatt
     5761 cggacaaaag aagagattaa acgtcagaag caggaacgca gtcataatca taactcaaga
     5821 gcagataatg ctgttgctgc agccagagcc caaggacgct acaccacaga tgatggttat
     5881 atctttaatg cttctgatat cattgaagat actggtgatg c
//
LOCUS       DBERMM010000072         5701 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.074, whole genome shotgun sequence.
ACCESSION   DBERMM010000072 DBERMM010000000
VERSION     DBERMM010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5701)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5701)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5701
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.074"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            83..880
                     /locus_tag="ACL8AS_002002"
     CDS             83..880
                     /locus_tag="ACL8AS_002002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015499 - formate transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0015724 - formate transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HGS1229799.1"
                     /translation="MISSEFISKIEFACNKKESLYSQSKFKYAIRSMFAGAFLTFSTA
                     AGAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISW
                     RKTAEILLYCTLFNLIGALIAGWGFAHSAAYANLTHDSFISGVVEMKLGRSNELVLLE
                     AILANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVA
                     ADSIANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     gene            1028..2287
                     /locus_tag="ACL8AS_002003"
                     /pseudo
     CDS             1028..2287
                     /locus_tag="ACL8AS_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0019346 - transsulfuration [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
     gene            2383..3657
                     /locus_tag="ACL8AS_002004"
     CDS             2383..3657
                     /locus_tag="ACL8AS_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HGS1229800.1"
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTTEFDKELHDRMRQEL
                     ALAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHQALLAKDKEV
                     QALENQLATLRLEHENQLQKTLSDLEKERNQVKNQLLLQEKENELSLASVKQNYEAQL
                     KAASEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGS
                     KGDFIFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLV
                     TMLEADNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVRE
                     QNIDITHFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQL
                     RLANNKLEDVSVKKLTRKNPTMKAKFEALKGE"
     gene            3669..>5701
                     /locus_tag="ACL8AS_002005"
     CDS             3669..>5701
                     /locus_tag="ACL8AS_002005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HGS1229801.1"
                     /translation="MEDDLNYENLMDDVTEAIKKFNLVIFIGAGVSIAQGYPNWNNYI
                     EHLIKYWQGQVLSVSGEKRLGREHHVVFDLISKSSISNKRKVDLVNYELKKVFGEDFE
                     KRRLDFEKGYFKNLLPYSIVNQTVESLASLNAIFITSNYDYEIENHIKRLKNAVVTIN
                     DLNEFTKNKNGKLQFGDVLHIHGTPDCDVKYFVSSSADYSKTYLKNRENFENLVTWFK
                     ETKPTVLFIGAGLEEDEILSLLCKDSKNYALMKSENTGNQRVDEHYRGVVEGFFSSEN
                     HTQIIWYGDEFEKLPLFVKKLVADINEKLGTHDFYNQWNNLLNPSINQEEYNKNLDSI
                     SNDFKYLSSVLDKVIENDNNQLDQLMLNALLRSETLTVIKKNFVLAFWKFIVKNIEKL
                     SDNEWDVIYKIIYEGSQNYFIDDVFFVYNYAIDNKISSFTNNNKLNELREIISKDGYI
                     VNSNFNKDKTLLGYWLVSAFEQQNRDLYIEEDSEVEVNLNYECVNKLMSILNNPEFLS
                     YNYYSIEHQLKEYDVVKFLYELVKSKKLFIEEEKFLESDSEDLISTILIQKLLVQLDN
                     EINLDLEFIKRLIDKIDFSNIHFGEELNTFIKEHRSIIREKNIEIPKKPYRNWISSLE
                     GGFVSQFSYLTQENLVEYDESRVLEILVNAEKEQRGSSFLEEKTINETENFFIT"
BASE COUNT         1905 a          885 c         1149 g         1762 t
ORIGIN      
        1 acttttatga aatacagaaa acgcttccta aaacctaaag tttgtgatat aattatcaag
       61 aaaaaagatt taggagttta ttatgatttc ttcagaattt atctcaaaga ttgaatttgc
      121 ttgcaataag aaagaaagtc tttatagtca aagcaaattt aagtatgcga ttcgttcgat
      181 gttcgcaggt gcatttttaa ccttcagtac tgctgcaggt gcagttgggg ctgacttgat
      241 taataaaatt gcaccaggta gtggacgctt cctctttcca ttcgtttttg cttggggctt
      301 ggcctacatt gtttttttga atgccgagtt ggtcacttca aacatgatgt tcttgactgc
      361 tggtagtttc ttaaaaaaaa tctcttggag aaaaacagct gagattttac tatactgtac
      421 cttgttcaac cttatcggag ccttgatagc agggtggggc tttgctcatt cggcagccta
      481 tgcgaatctg acacacgata gtttcatctc aggtgttgtt gagatgaagt taggccgctc
      541 aaatgaattg gtcttgcttg aggcgatttt ggcaaatatt ttcgtaaata ttgcgattct
      601 gtcatttatt ttggtcaaag atggtggtgc caaactttgg cttgtgttgt cagctattta
      661 catgtttgta ttcttaacaa acgagcacat tgcggcgaac tttgcttctt tcgcgattgt
      721 gaaattcagt gttgctgcgg attcaattgc caacttcggt gttggaaata tgcttcgcca
      781 ctggggtgtg actttcatcg gaaactttat cggaggaggc ctcttgatgg gtcttccata
      841 tgccttcctc aataaaaacg aagatactta tgtagattaa gaaaatgagc acgattgagt
      901 cgtgcttttt tcattttcaa aataaggtaa tagctatttc ttatatcaaa atatagaaaa
      961 ctgatatttg taaactataa ctcaaggtgc tacaatatcc ttaataaaat gatatggagg
     1021 tcaccttatg acttgtgatt ttaaatttga aactctacaa ctacatgctg gtcaagttgt
     1081 ggctccagct actaagtctc gtgcagtgcc gatttatcaa acaacatttt ttgtttttga
     1141 tgacacgtag gaaggtgccg atctgtttgc cttgaggaaa ccagggaaca tttatactcg
     1201 tatcaccaat cctacaacag ctgcccttga aggtggtgtt gaagcgctag caacagcatc
     1261 aggtatgact gcagtgactt atacgatttt ggcgcttgcc catgctggtg agcatgtagt
     1321 ggctgcttcg actatttacg gtggaacctt caatcttttg aaaaaacccc ttcctcgtta
     1381 tggtatcaca acaacctttg tcgatgttga taatttggag gaagtagaag cagctatcaa
     1441 agacaatacc aagcttgtct tgattgaaac cttgggtaac cccttgatta atattccaga
     1501 cctggaaaaa ctggcagaga ttgctcataa acatcaaatc ccacttgtgt cagacaatac
     1561 ttttgcaaca ccttatttga ttaacgtctt ctctcatggc gttgacattg ccattcactc
     1621 tgcgactaag tttatcggtg ggcatggtac aactattgga ggaataattg tcgatagtgg
     1681 tcgttttgac tggacggctt cagggaaatt ccctcaattt gttgacgaga gtccaagctg
     1741 ccacaatttg agctatactc atgatgtggg tgcagcagcc tttattatag ctgttcgagt
     1801 tcaattgctt cgtgatacag gtgcagcctt gtcaccattc aatgctttcc tcttgctaca
     1861 aagacttgaa accctttcac ttcgtgtgga acgccatgta caaaatgctg agacaattgt
     1921 tgattttctt gtcaaccatc ctaaggtaga aaaggtaaat tatccaaaac ttgcagatag
     1981 tccttattat gccttggctg agaaatactt gccaaaaggt gtcggttcaa tctttacctt
     2041 ccacgtcaaa ggcgacgagg aggaagcacg caaggtcatt gataatttag aaatcttttc
     2101 tgaccttgca aacgcagcag atgctaaatc gcttgttgtc catccagcaa caatcactca
     2161 cggtcaattg tcagaaaaag acctagaagc agcaggtgtc acaccaaatc aaatccactt
     2221 gtctatcggt cttgaaaatg tagaagattt gattgaagac ttacgcttgg ccttggaaaa
     2281 aatttaaagt aaaagaagat aaacagtggg ttttgactca ctgtttttga ttttccctca
     2341 ggcatgatat aatggttaca gaagtctaga aagaggaatg taatgaacga aatcaaatgt
     2401 cccaactgtg gggaagtctt tacagtaaat gaaagccagt atgctgaact tttgtcccaa
     2461 gtgagaacga cagagtttga taaggaacta cacgatagga tgaggcagga actggccttg
     2521 gctgagcaaa aggctatgaa tgagcaacag actaaactgg ctcagaagga tcaagaaatt
     2581 gcgcaattgc agagtcaaat ccaaaacttt gatacagaaa aagaattggc caagaaagaa
     2641 gttgaacaga caagccatca ggccttattg gctaaggaca aggaagtaca ggccttggaa
     2701 aaccagttgg cgaccttgcg tttggagcat gaaaatcaat tgcaaaagac cctttctgac
     2761 ctagaaaaag aacgcaatca ggtcaaaaat cagctcctac tgcaagaaaa ggaaaatgag
     2821 ttgtctttgg cttctgttaa gcaaaactac gaagcccagc tcaaagcagc cagtgaacaa
     2881 gtcgagtttt ataagaattt taaggctcaa caatctacaa aagcgattgg ggaaagccta
     2941 gaacagtatg cagagagtga gtttaacaag gttcgtagtt tcgcctttcc aaatgcttac
     3001 tttgagaagg ataacaaggt ctcttcgcgt gggtctaaag gggactttat cttccgtgag
     3061 tgtgatgaaa atggagttga aatcatttct atcatgtttg agatgaaaaa cgaagcggac
     3121 ggaacagaga agaagcacaa gaatgcagat ttttacaagg aattggacaa ggaccgtcgg
     3181 gagaagaact gtgagtatgc cgttttggtg accatgcttg aggctgataa tgactacttt
     3241 aacacaggga ttgttgacgt cagtcacgag tatgaaaaaa tgtatgttgt tcgtcctcaa
     3301 ttctttatcc aattgattgg tctcttacgt aatgcggcgc taaattccct aaaatacaag
     3361 caggagttgg ccttggttcg cgagcaaaat attgacatta cgcattttga ggaagacttg
     3421 gatgccttta agctagcttt tgctaagaac tataattcag cttcgactaa ctttggaaaa
     3481 gctattgatg aaatcgacaa ggccatcaaa cgcatggaag aggttaagaa attcctgact
     3541 acatctgaaa accaactccg tctagctaac aacaaattgg aagatgtctc tgttaaaaaa
     3601 ttgacccgga aaaatccaac aatgaaagcg aagttcgaag cactgaaggg ggagtgagga
     3661 aataagttat ggaagatgat cttaattatg aaaatttgat ggatgatgta accgaggcta
     3721 taaaaaagtt taacttagta atttttattg gcgcaggagt ttcaattgct caaggttatc
     3781 ctaattggaa caattatatt gaacatctta ttaagtattg gcaaggacaa gttttatcgg
     3841 taagtggtga aaaaaggctt ggaagagaac atcacgtagt ttttgattta attagcaaat
     3901 ctagtattag taataaacgt aaagtggatc ttgtaaacta tgaattaaaa aaagtttttg
     3961 gtgaagattt tgaaaagcga cgactagatt ttgaaaaagg atattttaaa aatctattac
     4021 catattcaat agttaatcaa acagtagaat ctttagcaag tttgaatgca atatttatta
     4081 cttctaacta cgactatgaa attgaaaatc atattaaacg tttaaagaat gctgtagtta
     4141 ctattaatga tctcaatgaa ttcactaaga acaagaatgg gaaactacaa tttggtgatg
     4201 ttctacatat ccatggaaca ccagattgtg atgtaaagta ttttgtaagt tcatccgcag
     4261 attattcaaa aacctattta aaaaataggg aaaattttga aaatttagta acatggttta
     4321 aagagacaaa acctactgtt ttatttattg gagcaggtct tgaagaagat gaaattttat
     4381 ctttactttg taaagatagt aagaactatg ccttgatgaa gtcagagaac acaggtaatc
     4441 agagagttga tgaacattat agaggtgttg ttgaaggatt ttttagctca gaaaatcata
     4501 ctcagattat ttggtacgga gatgaatttg agaaactacc tctttttgta aaaaaattag
     4561 ttgctgatat taatgaaaaa ttgggcacac atgattttta taatcagtgg aacaatcttt
     4621 tgaatccttc tataaatcaa gaagagtata ataaaaatct agatagtatt tctaatgatt
     4681 ttaagtatct aagctctgtt ttagataagg ttattgaaaa tgataataat caactagatc
     4741 agctaatgtt aaatgctctg cttcggagtg aaactctaac agtaattaaa aaaaattttg
     4801 ttcttgcatt ttggaagttt attgttaaga atattgaaaa gttaagtgat aatgagtggg
     4861 atgtgattta taaaataatt tatgaaggct ctcaaaatta ctttatagat gatgtattct
     4921 ttgtctataa ttatgcgata gataataaaa tttctagttt tacaaataat aataagctta
     4981 atgaactgag agaaattata tccaaagatg gatatatcgt taattctaac tttaataaag
     5041 ataaaactct tttgggttac tggctagtaa gtgcttttga acagcaaaat cgtgatttat
     5101 atatagagga agatagtgaa gtagaagtta acttaaatta cgaatgtgtt aacaaattaa
     5161 tgtccatact aaataatcca gaatttttaa gttataatta ctactctata gagcatcaat
     5221 taaaagagta tgatgttgtt aaatttcttt atgagcttgt aaagtccaaa aaattattta
     5281 ttgaagagga aaagttttta gaaagtgatt ctgaagactt aataagtact atattaattc
     5341 aaaaattgct tgttcaattg gataatgaaa ttaatttgga tttagaattt atcaagaggt
     5401 taattgataa aattgatttt tcaaatattc actttggaga ggaattaaac acttttatca
     5461 aagaacatag aagtattatt agagaaaaaa atattgaaat accaaaaaaa ccttatagaa
     5521 attggatatc ttcactagaa ggaggttttg tttcacaatt ttcatattta actcaagaaa
     5581 atcttgtaga gtacgatgaa tctagagtat tagagatatt agtcaacgcc gaaaaggaac
     5641 aaagaggttc ttcatttttg gaagaaaaga cgataaatga aacggaaaat ttctttatta
     5701 c
//
LOCUS       DBERMM010000073         5481 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.075, whole genome shotgun sequence.
ACCESSION   DBERMM010000073 DBERMM010000000
VERSION     DBERMM010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5481)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5481)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5481
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.075"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            64..897
                     /locus_tag="ACL8AS_002006"
     CDS             64..897
                     /locus_tag="ACL8AS_002006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="HGS1229802.1"
                     /translation="MNPLKECYEKNGILIAAHRGTNGGNILQNTSKAYLNSIRHNADM
                     FEVDVIRSKDGEFFAFHDGQEPLVFGEKIDIRTLSSEEIQRKECFNSLNEPILQKIEK
                     ISDVLKNFEGQSLINIDRSWFYWDTFLDKLKTYPSLNQVLLKSPVKKELLEMLRDSGL
                     NIMYMPIIKTIEELDFVLSFEGINIVAVELVFQDLENPIISKKVIDDLHEKGLLIWVN
                     ALTLSDSIILSAKIDDDTAIAHDGESWGKLVSIGFDIIQTDWPLLLYQYLVEKNKKIK
                     K"
     gene            924..1985
                     /locus_tag="ACL8AS_002007"
     CDS             924..1985
                     /locus_tag="ACL8AS_002007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HGS1229803.1"
                     /translation="MFKNFKKIAFTSSLILLAACSNNASNTNQSTDEGSVDKSQEIVI
                     YTNSASNGRADWLQTKASEQGYNLRLVDISGGELADRLIAEKNNAVADMVIGLNKLEF
                     NRIKAEKLLVKYSPKWADEVDSSLGDSEGYYSPIVNQPLVLIGNKDAKMPSDWTDFTD
                     SSYKGKYGISKLSTGTSKNIFASIVSRYKDEKGELGISDEGWKVAKAYLKNAHVYAEG
                     EDYISSIMDNNNELKYSMMWGSGVLQNQKEREYKFQVMSPKVGVPYVTEQVGILNTSK
                     KQALLKEFVDWFGSSELQKEWSDKFGSIPANKKALEQAKDELKQFANSVKPQELDWEF
                     IGKNIDSWIEKAQLEFVEQ"
     gene            2002..3006
                     /locus_tag="ACL8AS_002008"
     CDS             2002..3006
                     /locus_tag="ACL8AS_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HGS1229804.1"
                     /translation="MITFKDIQIKYNDFIAIDNLNLTINEGEFFTFLGPSGCGKSTTL
                     RALVGFLEPSQGQILVDNQDITNLDPEKREIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VSPEIIKAKVHEIAKKINISDEQLNRNISELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVSLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGFIEQVGTPY
                     DIYNQSETQFVCDFIGSINKISQEVLKKLQGENKYFKETEGYIRLERVKLEKTSPQDL
                     SITGVISDIEFNGVLIKYKVDLSNSESIHIIEKNDGLSRHIIEEKVTMYINPRDIMQF
                     "
     gene            3018..4712
                     /locus_tag="ACL8AS_002009"
     CDS             3018..4712
                     /locus_tag="ACL8AS_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229805.1"
                     /translation="MRKSLNWKDWLIRLGVLWLIFALIIYPNIELLSGVFYKNGSFTL
                     EAFNKIIHSQRAMSSIFNSFILAISMVFTVNIVGTLIVLLTEYWDIRGSKILKLGYMS
                     SLVYGGIVLATGYKFVYGANGLVTKTLSSIIPGLAPNWFQGFGAVLFIMTFACTSNHI
                     MFLTNAVRSVDYHTIEAAKNMGASPLKVFFSVVFPTFKPTLFALTILTFLTGLSAVSA
                     PLIVGGKDFQTINPLIISFAKTTSSRDLAALLAIMLGLATILLLTLLNHVEKGGNYVS
                     VSKTKASIKKQIISSPLWNTLAHIVAYVLFAIYMLPIVLIILYSFTDSLTIKTGTLDL
                     SKFTLANYANLFTDAQSFRPYLVSVVYAILAAVIATIIAIVISRIVHKNKSKFDKFFE
                     YGALIPWILPGTLIALGLMFTYNIPHLILFNLVLVGTVIILLIAYTIQKLPFSYRMIR
                     AVFFSIDNDMEEAARSMGASSFYTMVRVIIPYILPVVLSVVVLNFNSLLSDYDLSVFL
                     YHPLFQPLGIVIKQSTDETATLNAQAMMFVYSVILMIMSSAALYLSSLFQGKRGKR"
     gene            4714..5415
                     /locus_tag="ACL8AS_002010"
     CDS             4714..5415
                     /locus_tag="ACL8AS_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001054457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HGS1229806.1"
                     /translation="MNLSYELSIWEILLRCFLAILFGGIVGYERGVKNQAAGIRTYLL
                     VCLGTCVVMMTNQFITSRYGSGDPSRMGAQVISGLGFLGAGTIMVTNQKVKGLTTAAG
                     LWSSATIGLAIGIGFYEGAILAGVVLIAVLTLFTPLKDYLNSKTKIADYYLVFSSLEG
                     YNRLLIYLNTSGIKILEIQNGIGNLDEERQLNKIKSTKVSCYLSLKLNENFEHLKLME
                     EMHNIAGVIYVEEIR"
BASE COUNT         1891 a          752 c         1001 g         1837 t
ORIGIN      
        1 ctattgacac gttccaggaa atcggataca atgtaattaa caataaagat aggagaaaat
       61 aatttgaatc cattaaaaga atgctatgaa aaaaacggta tactaattgc agcacaccgt
      121 ggtacaaacg gaggaaatat attacaaaac acatcaaaag cctatttgaa ttccatacgc
      181 cataacgcag atatgtttga ggttgatgta attcgttcaa aagatggaga attttttgca
      241 tttcacgatg ggcaagaacc tttagtattt ggtgaaaaaa ttgatattag aactttgagt
      301 tctgaagaga tccaaagaaa ggaatgtttt aattcactga atgaacccat attacaaaag
      361 attgaaaaaa tttctgatgt attaaaaaat tttgagggac agtctttaat aaatatagat
      421 agaagttggt tttactggga taccttccta gataagttaa aaacatatcc atctttgaat
      481 caagttcttt taaaatcacc tgtaaaaaaa gaattattgg aaatgcttag agactctggt
      541 ttgaatatta tgtatatgcc aattatcaaa acaattgaag agttagattt tgttctctca
      601 tttgaaggaa taaatatagt agctgtcgaa cttgtattcc aagatttaga aaatccaatc
      661 ataagtaaga aagtaattga tgatttacat gaaaaaggat tacttatttg ggttaatgct
      721 ttaaccttaa gtgattcaat tattctttcg gctaagattg atgatgatac agctattgct
      781 catgatggcg aatcttgggg gaaattggtt tcaataggat ttgatattat tcaaacagat
      841 tggccattat tactttatca atatctagtt gaaaaaaata aaaaaataaa aaaataaaaa
      901 aataaaaata aaggagaact atcatgttca aaaactttaa aaagattgca ttcacttctt
      961 cactaatttt acttgctgct tgctcaaaca atgcttcaaa tacaaatcag tctactgatg
     1021 aaggaagtgt tgataaatct caagaaattg taatctatac aaattcggct tctaatggac
     1081 gtgcagattg gttacaaacc aaagcatcag agcaaggata caatcttcgt ttggtagata
     1141 tttcaggtgg agaactagct gaccgtttga ttgcagaaaa gaataatgct gtggctgata
     1201 tggtaattgg attaaataaa ttagaattta accgtattaa agctgaaaaa cttcttgtaa
     1261 aatactcacc aaaatgggct gatgaagtag atagctcttt gggagattct gaagggtatt
     1321 attcaccaat tgtaaatcaa ccattagttt tgattggtaa taaagatgct aaaatgccat
     1381 ccgactggac agattttact gattcatctt ataaaggtaa atatggtatt tcaaaattaa
     1441 gtacaggtac atctaagaac atctttgcaa gtattgtttc gagatataaa gatgaaaaag
     1501 gtgagttagg aatatctgat gaaggttgga aagttgcaaa agcttacctt aaaaatgcac
     1561 acgtttatgc agaaggtgaa gactatatct cttcaattat ggataataat aatgagctaa
     1621 aatatagtat gatgtgggga tctggtgttc tacaaaatca aaaagaacgt gaatataaat
     1681 tccaagtaat gtcaccaaaa gttggtgttc cttatgtaac tgaacaagtt gggattttaa
     1741 atacaagtaa gaagcaagca ttattaaaag aatttgtaga ttggtttggc tcttcagaac
     1801 ttcaaaaaga atggtctgat aaatttggtt caattccagc taataaaaaa gctctagagc
     1861 aagcaaaaga tgaactcaaa cagtttgcta atagtgttaa accacaagaa cttgactggg
     1921 agtttatcgg aaaaaacatc gattcttgga ttgaaaaagc acagcttgaa tttgttgaac
     1981 agtaatagtt aggattaagt gatgattaca tttaaggata ttcaaattaa gtataatgat
     2041 tttattgcca tcgataatct caatttaaca atcaatgaag gagagttttt cacattttta
     2101 ggaccaagtg gttgtgggaa atcaacaact cttcgtgcac tagttggatt tttggagcct
     2161 tcacaggggc aaatactagt tgataatcaa gatattacga atttagatcc ggaaaaacgc
     2221 gaaattggta ttgtgtttca aagttatgca ttattcccaa caatgactgt ttttgataat
     2281 attgcttttg gtctaaaagt taaaaaagtt tctcctgaaa ttattaaagc taaagttcat
     2341 gaaattgcga aaaaaattaa tatctcagac gagcaactaa accgaaatat ttctgaatta
     2401 tcagggggac aacaacagcg tgtagcttta gcacgtgcat tagtattaga accaaaaatt
     2461 ctttgtttgg atgaaccgtt atcaaaccta gatgccaaac tacgagtttc gttgagaaaa
     2521 gaattgaaac gattgcaaaa agaactagga atcactactc tttatgtcac acatgatcaa
     2581 gaagaagcat taacattatc agataggatt gctgtgttta ataatggatt tattgagcaa
     2641 gttggcacgc cgtatgatat ttataatcaa tccgaaactc aatttgtctg tgattttatt
     2701 ggctcaatca ataaaattag ccaagaagtt cttaaaaaat tacaaggcga gaataaatac
     2761 tttaaagaaa ctgaaggata catacgctta gagcgtgtta agttagagaa aacttcacct
     2821 caagatttat ctataacagg agtaattagt gatattgagt ttaatggtgt acttattaag
     2881 tataaagtag acttgtcgaa tagtgaaagt attcatatta tcgaaaagaa tgatggacta
     2941 tcacgtcata taatcgaaga aaaagtcact atgtacatta atccgcgtga tataatgcaa
     3001 ttttaaggag attgtgcatg agaaagagtc taaactggaa agattggctc ataagattag
     3061 gagttttatg gctaatcttt gccctgatta tttatccaaa tattgaactt ttgtctggag
     3121 tgttttataa aaatggttca tttactctag aggcattcaa taagattata cactctcaga
     3181 gagcgatgag tagtatattt aatagcttta ttttggcgat ttcaatggtc tttactgtaa
     3241 atattgttgg gacattgatt gttctactca cagagtactg ggatattagg ggttcaaaaa
     3301 tacttaaatt aggttatatg agctctctag tatatggagg aattgtatta gcgacaggat
     3361 ataaatttgt ttatggcgct aatggtcttg taactaaaac gctctcaagt ataattccag
     3421 gtcttgcccc taactggttt caaggatttg gtgcagtatt gtttattatg acatttgctt
     3481 gtacctcaaa tcacataatg tttttaacaa atgcagttcg tagtgttgat tatcatacaa
     3541 ttgaagcagc taaaaatatg ggtgcaagtc ctttaaaagt tttctttagt gtggtttttc
     3601 caacttttaa acctacgtta tttgccttaa ccatcttaac ttttttgaca ggtctttcag
     3661 cagtttctgc tcctttgata gtagggggga aagattttca aactattaac ccattgatta
     3721 tcagtttcgc taaaactaca agttcgagag atttagcagc tttactagct atcatgttag
     3781 gtttagcaac tattctatta ttgacacttt tgaatcatgt cgaaaaagga ggtaattatg
     3841 tatctgtttc gaaaaccaag gctagtatta agaagcagat aatttcttct ccattatgga
     3901 atactcttgc tcacattgtt gcgtatgtat tgtttgcaat ctatatgtta ccaatagttt
     3961 tgataattct atactcgttt acagactcgt tgacgatcaa gacgggaact ttagatctat
     4021 ctaaatttac gttagcgaac tatgctaatt tatttacaga tgctcaatca tttcgtcctt
     4081 acctagtcag cgttgtttat gcaattttag ctgcggtaat tgctacaatt atagcaatag
     4141 taatttcacg tattgtacat aaaaacaaga gtaagttcga taaattcttt gagtatggtg
     4201 cactaatacc atggatattg ccaggtacat tgattgcact aggattaatg ttcacttata
     4261 atatacctca tttaatacta tttaatttag ttttagtagg aacagtaatt attttactta
     4321 ttgcatatac tattcaaaaa ttaccatttt cttatagaat gattcgggct gtatttttca
     4381 gtatagataa tgatatggaa gaagcagcac gtagtatggg tgcatctagt ttctacacta
     4441 tggtgcgagt tattataccg tatattttac cagtcgtatt atcagtagtt gtgttaaact
     4501 ttaattcttt attatctgac tatgacttat ctgtattctt gtaccatcca cttttccaac
     4561 cattgggaat cgttattaaa cagtctactg atgaaacagc aactttaaat gcacaggcaa
     4621 tgatgtttgt ttattctgta attttaatga ttatgtctag tgcagctctt tatttatcaa
     4681 gcctattcca aggtaaacga ggtaagagat aatatgaatc tttcatacga actgagtatt
     4741 tgggaaatac ttcttaggtg ctttttagcg attcttttcg gtggcattgt tggctatgag
     4801 cgaggagtca aaaaccaagc agcagggatt agaacctact tactagtttg tttgggaact
     4861 tgtgttgtaa tgatgacaaa tcagttcatc actagtcgtt atggtagcgg tgatcctagt
     4921 cgaatgggag cccaagtaat tagtggcttg ggtttcctag gggcaggaac aatcatggta
     4981 actaatcaaa aagttaaagg tttaacaaca gcagctggat tatggtcttc agcaactatt
     5041 ggtttagcta taggcattgg tttttatgaa ggtgctattt tagccggagt tgtactcata
     5101 gcagttttaa ctctatttac tcctcttaaa gattatttaa actcgaaaac taaaattgct
     5161 gattactact tggtttttag ttctttagaa ggttataatc gtttacttat atatttaaat
     5221 acatcgggta ttaagatttt agaaattcaa aatggtatag gaaatcttga tgaagaacgt
     5281 caattaaata aaattaagtc aacaaaagtg tcctgctatt tatcattaaa attaaacgaa
     5341 aactttgaac atttaaaatt aatggaagaa atgcataata ttgctggggt tatttatgtt
     5401 gaagagatta ggtaagggtg actttgtcta attttttcta tatttctaat cggagaaaaa
     5461 aatgaatata atttttgatt t
//
LOCUS       DBERMM010000074         4660 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.076, whole genome shotgun sequence.
ACCESSION   DBERMM010000074 DBERMM010000000
VERSION     DBERMM010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4660)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4660)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4660
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.076"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            76..1335
                     /locus_tag="ACL8AS_002011"
     CDS             76..1335
                     /locus_tag="ACL8AS_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TRZ/ATZ family protein"
                     /protein_id="HGS1229807.1"
                     /translation="MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQ
                     AEQIIDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTT
                     NAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
                     ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVTE
                     TKEESGIILKRYGKRPLAFLEELGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPI
                     SNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTAALLQKMKSGDASQF
                     PIETALKVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYA
                     VKSSDVDDVYIAGEQVVKQGQVLTVEL"
     misc_feature    1411..1546
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            1585..2085
                     /gene="rplJ"
                     /locus_tag="ACL8AS_002012"
     CDS             1585..2085
                     /gene="rplJ"
                     /locus_tag="ACL8AS_002012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HGS1229808.1"
                     /translation="MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRR
                     ELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNNFSK
                     NAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAE
                     SKEDAA"
     gene            2161..2529
                     /gene="rplL"
                     /locus_tag="ACL8AS_002013"
     CDS             2161..2529
                     /gene="rplL"
                     /locus_tag="ACL8AS_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HGS1229809.1"
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAA
                     DAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVAT
                     AEAEEIKAKLEEAGASVTLK"
     gene            2665..2838
                     /locus_tag="ACL8AS_002014"
     CDS             2665..2838
                     /locus_tag="ACL8AS_002014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229810.1"
                     /translation="MQKEGQSSRQFVKSHLMTIMGVDIVKATQLVDEMEQVGLIRFDE
                     FGNVGILVLEGQS"
     gene            2835..3083
                     /locus_tag="ACL8AS_002015"
                     /pseudo
     CDS             2835..3083
                     /locus_tag="ACL8AS_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
     gene            3097..3420
                     /locus_tag="ACL8AS_002016"
     CDS             3097..3420
                     /locus_tag="ACL8AS_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229811.1"
                     /translation="MTFLDDYHKKHNYPLFYESYLQNVMEFLESQDIKNGVDAFVDDH
                     QNLVFVLYGQGYRAEGKEGILTTQVTVKAYDEDKKPINFANLLDSLIVSEYQMEANLL
                     EVSHD"
     gene            3413..3793
                     /locus_tag="ACL8AS_002017"
     CDS             3413..3793
                     /locus_tag="ACL8AS_002017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HGS1229812.1"
                     /translation="MIDLYLSKNSQRNQLLLDFFQNYGIEVSCHSVSEMTKDKLIEMM
                     SYSSDCFEFLSPNLLRFKNRDNLRLTDFVEIILKNPELTIGLPFVVSNKRVYPSLNLE
                     EARALLPRDTKQLIYMAQTHYLSN"
     gene            3806..4039
                     /locus_tag="ACL8AS_002018"
     CDS             3806..4039
                     /locus_tag="ACL8AS_002018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HGS1229813.1"
                     /translation="MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQK
                     IRHYKMEQRMPQSPWVERIVQILDLDYEDLFRR"
     gene            4042..4629
                     /locus_tag="ACL8AS_002019"
     CDS             4042..4629
                     /locus_tag="ACL8AS_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="HGS1229814.1"
                     /translation="MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQVLYGASLFS
                     FLWMYGQRKQVVKVNMKTRMKCLGIGLASLLIISLCFSLIHAQGSTNQTNLIGLQHQV
                     PWFSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALVHHPGTILAWCLYV
                     SLGMFLGMVRYKSDLWGSMGLHLVWNFLVYSLLLF"
BASE COUNT         1477 a          799 c          982 g         1402 t
ORIGIN      
        1 aaccacacct acggcaaagt gaatctgaag tggtttgaag agagtacaac ttgtctttta
       61 aaaaaggagt ctataatgaa agtctttcag catgtaaata tcgtgacttg tgatcaaaat
      121 ttccatgttt atcttgatgg aatcttagca gtcaaggatt ctcaaatcgt ctatgttggt
      181 caagataagc cagcattttt agaacaagct gagcagatta tagactatca gggagcttgg
      241 attatgcctg gtttggtcaa ttgtcacacc cattctgcaa tgacaggtct gagagggatc
      301 cgagatgaca gcaatctcca tgaatggctc aatgactata tctggccagc agaatctgag
      361 tttactcccg acatgactac caatgcggtc aaagaagccc tgacagagat gctccagtca
      421 ggaacaacaa cctttaacga tatgtataat cccaatggtg tggatatcca gcaaatttat
      481 caggtggtga aaacttccaa gatgcgttgt tatttttctc cgactctctt ttcttcagag
      541 acagaaacaa ctgctgagac tataagcaga actcgatcca tcatagacga aatcttaaaa
      601 tataaaaatc caaatttcaa ggttatggta gcacctcatt ctccgtatag ctgcagtaga
      661 gacttgctgg aagcgagttt ggaaatggca aaagagctaa atattccgct ccatgtccat
      721 gtgacggaga ccaaggagga gtcaggaatt atcctcaaac gatacggcaa acgccccctt
      781 gcttttcttg aagaactggg ttatttagat catccgtccg tatttgctca cggggtcgaa
      841 ttaaacgaga gagaaattga acgcttggca tcttctcaag tggctatcgc ccacaatcct
      901 atcagtaacc tcaaactggc atcaggaatt gctccaatta tccagctcca aaaagcggga
      961 gtagcagtcg gaattgcgac tgactcggtt gcttccaata acaatctaga tatgtttgag
     1021 gaaggaagga ctgcagctct tcttcagaag atgaaaagtg gggatgccag ccagtttcca
     1081 atcgaaacag ctctcaaggt actgacaatc gaaggggcta aggcccttgg aatggaaaat
     1141 cagataggaa gtctggaagt cggcaagcaa gcagattttc tggtcattca accacaaggg
     1201 aaaattcatc tccaacctca ggaaaatatg ctgtctcacc tggtttatgc agttaaatct
     1261 agtgatgtag atgatgttta tatcgccgga gaacaggttg ttaagcaagg tcaagtcctg
     1321 acagtagaac tttaaaagaa aaatcacgaa aaattttaaa aaaagtttgc aaaaatcttg
     1381 cattcttttt ttgactatgc tatacttata tacggtttaa aaaaactgcc taagacagta
     1441 ggggagctcg actcataaat atcctaccga ggacaagacg tatcatgtaa aaagaagcgt
     1501 attgtacttt cgtgtctagg tttgggcgcg tttttctttt tgaaaaattc cccaagcaaa
     1561 ataattacgg aggtgaacac actaatgagt gaagcaatta ttgctaaaaa agcggaacta
     1621 gttgacgtag tagctgaaaa aatgaaagct gctgcatcta tcgtcgttgt agacgctcgt
     1681 ggtttgacag ttgagcaaga tacagttctt cgtcgtgagc ttcgtggaag cgaagttgag
     1741 tataaagtta ttaaaaactc aatcttgcgt cgtgcagctg aaaaagctgg tcttgaagat
     1801 cttgcatctg tatttgttgg accatctgca gtagcatttt ctaatgaaga tgttatcgca
     1861 ccagcgaaaa tcttgaacaa cttttctaaa aacgctgaag cacttgaaat taaaggtggt
     1921 gcaatcgaag gcgctgtcgc atctaaagaa gagattcttg cacttgcaac tcttccaaac
     1981 cgcgaaggac ttctttctat gctcctttct gtacttcaag cgccagtgcg caacgttgct
     2041 cttgcagtca aagcggttgc agaaagcaaa gaagacgcgg cttaatctta agctacacag
     2101 cgtagcctag ctacgaaaaa aactattata aaatttaaaa cttatttgga ggaaataaca
     2161 atggcattga acattgaaaa cattattgct gaaattaaag aagcttcaat ccttgaattg
     2221 aacgaccttg taaaagctat cgaagaagaa tttggtgtaa ctgcagctgc tcctgtagct
     2281 gttgctgcag ctgatgcagc tgatgctggt gctgctaaag attcattcga cgttgaattg
     2341 acatctgcag gcgacaaaaa agttggcgtt atcaaagttg tacgtgaaat tactggtctt
     2401 ggtcttaaag aagctaaaga acttgttgac ggtgcaccag cacttgttaa agaaggcgtt
     2461 gcaactgcag aagctgaaga aatcaaagct aaattggaag aagctggagc ttcagttact
     2521 cttaaataag aggcatatac caattagaat tcggaatact atagtatcag ccttttagaa
     2581 tcgtgaacac attttagaaa ctgataaatt ttcggaggta gacactagat tgtctacccc
     2641 tttttttgtg tttcggaggt aattatgcaa aaggaaggac agtcatcacg tcaattcgtg
     2701 aagagtcatc tcatgactat catgggagtt gatattgtaa aagcaactca gttagttgat
     2761 gaaatggaac aagtaggttt aatccgattt gatgaatttg gaaatgttgg aattttagtc
     2821 ttggagggac aatcatgaag cgtattaccg ctagtcaata tcagacatca gagcgttatt
     2881 ataagctccc caaactttta tttgagagtg aacggtataa gaatatgaaa ctggaggtta
     2941 aggtggttta ctcagtttta aaagatcggt tggagttgtc tttgagcaaa gcttggattg
     3001 atgaggatgg ggctatttat ttgatttatt ccaattcaaa tttgatggca cttttaggct
     3061 gttcaaagtc aaaattactc tccatgtgag tttgaggtga catttttaga tgattaccat
     3121 aaaaaacata attacccact attttacgaa tcctatcttc aaaacgttat ggaattcctt
     3181 gaaagtcaag acataaagaa tggggttgat gcctttgtag atgatcatca aaatctcgtt
     3241 tttgttttat atggacaagg ctatcgagcc gagggaaaag agggaatact tacaacccaa
     3301 gtaactgtaa aagcttatga tgaagacaag aaaccgatta acttcgcaaa tttattagat
     3361 tccttaatcg tctcagaata tcaaatggaa gcaaatttgt tggaggtctc ccatgattga
     3421 tctctatcta agtaaaaata gccaaagaaa tcaacttctt ttagacttct tccaaaacta
     3481 tggcattgag gtatcttgtc attcagtttc tgaaatgaca aaggacaaat taattgagat
     3541 gatgagctat tcttcagatt gttttgagtt tttatctccc aatttattac gatttaagaa
     3601 ccgtgacaat ctaagattaa cggatttcgt tgagataatt ttaaaaaatc ctgaactaac
     3661 catcggactt ccttttgtgg tttcaaataa gcgggtttat ccaagtctga atttggaaga
     3721 ggctagagct ctattgccaa gagatacgaa acaattgatt tacatggcac aaacacatta
     3781 tttatctaac taaaggagaa gtaatatggc tgaacgattt tgggagaact tgtccattat
     3841 tttggctgaa agaaatatca gctggattga gttaaccaga aaaatgtttg cgggagagtt
     3901 tcactatcca agtgaattga atcgtttata tcaaaagatt cgccactaca agatggaaca
     3961 acgaatgcct caaagtccat gggtagaaag gattgtgcag atattagatt tagattatga
     4021 agatttattt cggaggtaac tatgaaaaga ataattccag tttatatatt ccaacaagta
     4081 aatgtcctat tggtatctct atacttattg aaatttcttt gtatcggtga gttaactata
     4141 ctacaggttc tctatggtgc gtctcttttt tcttttttat ggatgtatgg tcaacgaaaa
     4201 caagtggtca aggtcaatat gaaaactagg atgaaatgcc ttggtattgg actagctagt
     4261 ctactgatta taagtctatg ttttagcctg attcatgctc aaggaagcac gaatcaaaca
     4321 aatttaattg gccttcaaca tcaagttcct tggttttcat ttttattgtt cttaatcaat
     4381 gcgagtatgg ttgaagaatt tctgtatcgt gaaattttat ggaacttggt tagaaaatta
     4441 gatattcgag ttgctttgac aagtgtttta tttgccttag tacatcatcc aggaaccatt
     4501 ctagcttggt gtctgtacgt ttcacttgga atgtttttag gtatggtgcg ctataaatct
     4561 gacttatggg gaagtatggg gttacatttg gtgtggaact ttttagttta tagtttgctg
     4621 cttttttaaa ataggtgacc tgatttatct cataaatctg
//
LOCUS       DBERMM010000075         4533 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.077, whole genome shotgun sequence.
ACCESSION   DBERMM010000075 DBERMM010000000
VERSION     DBERMM010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4533)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.077"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(108..356)
                     /locus_tag="ACL8AS_002020"
     CDS             complement(108..356)
                     /locus_tag="ACL8AS_002020"
                     /inference="COORDINATES: protein motif:HMM:NF022534.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helical hairpin domain-containing protein"
                     /protein_id="HGS1229815.1"
                     /translation="MVLSYRLLLFIIFLFNLFAKMNLTSTIKLEQVEKEIEENQRFMT
                     KWIDDYEYKVRRLENFINILDNTRNQNVTKLERETKSV"
     gene            complement(560..2383)
                     /locus_tag="ACL8AS_002021"
     CDS             complement(560..2383)
                     /locus_tag="ACL8AS_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002917262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="HGS1229816.1"
                     /translation="MVITKHFAIHGKSYRRKLIKYILNPDKTKNLTLVSDYDMRNFLD
                     FPSYEEMVQMYHENFINNDTLYNFRHDRLEEKQRQIHAHHIIQSFSPEDNLTPEQINQ
                     IGYETMKELTSGKFRFIVATHVDKDHLHNHIIINSVDSNSDKKLKWDYKVERNLRMIS
                     DRFSKIAGAKIIENRYSHQQYEVYRKTNHKYELKQRLYFLMEHSRDFEDFKKNAPLLH
                     VEMDFSHKHATFFMTDSSMKQVVRGNKLNRKQPYTEEFFKNYFAKREMEELMEFLLSK
                     AENIDDLIETAKLFDLTIIPKQKHVYFQLAGVEVKETELDQKNLYGVEFFQDYFESRK
                     DWQNPEIEDLVQFYQEEKFSKEKELPRDEKFWEFYQEFKSNRDAVHEFEVELSLNQIE
                     KVVDDGIYIKVKFGIRQEGLIFVPNMQLDIEEEKVKVFIRETSSYYVYHKDDPEKNRY
                     MKGRTLIRQFSSENQTIPFRRKTTVDMIKEKIEEVYTLLELDMDKHSYITIKDDLIHE
                     LAASELRINALQERVTTLNQVAEYLLASVENKQKMKLNLSKLNITDKIGIDVVEKELN
                     ELGIQIELESNRYENIVFKVNKFINRLSKKISKEEGICFQK"
     gene            complement(2370..2735)
                     /locus_tag="ACL8AS_002022"
     CDS             complement(2370..2735)
                     /locus_tag="ACL8AS_002022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="HGS1229817.1"
                     /translation="MEHRYRINLKKVFLSDIELNQLNRNIDQSSCQSFSEYARRTLLD
                     PGMNFITIDTNGYQDLVFELKRIGNNINQIARSVNQSQLISSEELQELKKGIAELIKE
                     VEKEFTIQAQKLREFHGHH"
     gene            complement(2740..3096)
                     /locus_tag="ACL8AS_002023"
     CDS             complement(2740..3096)
                     /locus_tag="ACL8AS_002023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000817622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1252 family conjugative relaxosome accessory
                     protein"
                     /protein_id="HGS1229818.1"
                     /translation="MKRDVRDIRKQFRLTDEEEKQILALMREQGDTNFSDFLRKSLLS
                     SDLQKQIEIWFTLWQSQKLEQISRDVHEILISIQSERQVTQEHVSILLTCVQELIKEV
                     GNSIPLSQDFQDKYMR"
     gene            3458..>4533
                     /locus_tag="ACL8AS_002024"
     CDS             3458..>4533
                     /locus_tag="ACL8AS_002024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000949621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HGS1229819.1"
                     /translation="MLSLDQIHLLLNTPEDEFHDFKQKWHHSKTELVRDILNFVNTSH
                     HEDCYIIFGIDNITLDIIGVNNDDNRRNEEDLTDLLHKLFISTNNQIRISIQTETIDN
                     KEIDILIIHDTDKVPVFLTKDYKPKKDTALQKGLIYARNGSINTPKDSSAPFELINKL
                     FQKFNHTDLNIKEQYFHVLKDYKNWFFVENEDGRFFIYNPNPDFYIKLTDDDANRFKT
                     MPYSLNQYQTNVDWQLVQLRYRHLTIIDFMALYLDQGNCLVPSPDLEDFECGYSDTIY
                     YHCLYKNTLKYQLLKVFSSISGLEKYPLDRFKNNIVIYDDKIELEKTHNLIKSNFSTE
                     EIMKQLEVTEKDFDFYYKKARQKNP"
BASE COUNT         1453 a          815 c          680 g         1585 t
ORIGIN      
        1 tagttaatct tgacattata gtttttctga aacgttaaat aacctgtaag gctgatagtg
       61 atattaatac tatcagcctt ataatttttc catggtatct ccaataacta tactgatttt
      121 gtttcccgtt ctaatttggt aacattttga tttcttgtat tatcaagtat attgataaaa
      181 ttctctaatc tcctaacctt atattcgtaa tcatctatcc atttagtcat aaatctttga
      241 ttttcttcga tttctttctc cacctgctcc agtttgatag ttgaagtcag gttcatcttg
      301 gcaaagagat tgaaaagaaa aatgataaat aagagtaaac gataagataa aaccattgag
      361 cagttgaatt tatccaacaa atcaataaaa aaactagtaa ggaaataagt gaataaatat
      421 aaggagatat ttgctcaaaa tgatgatttt tttgtatcgt atgtgataac taaatctacg
      481 actgatgcaa taaaaaatat cataattcca aatatgtttt ataaaagata cacattttat
      541 ataatggttg tctgggttcc tatttttgaa aacatatccc ttcttctttt gaaattttct
      601 tactcaaacg attgataaac ttattcactt taaatacgat attctcatat ctattgctct
      661 ctaattctat ctggatacct aactcattca attccttctc aacaacatca atgccaattt
      721 tatcagttat attcaatttt gaaagattca atttcatttt ttgcttattt tcaactgaag
      781 ccagtaaata ttctgctact tgatttaagg ttgtcactcg ttcttgcaaa gcattgattc
      841 tcaattctga agctgccaat tcatgaatta aatcatcttt aattgtaata taagagtgct
      901 tatccatatc cagctcaagt aaagtataca cttcctcaat cttctcttta atcatatcga
      961 ctgtcgtttt tctgcggaat ggaatcgttt gattttcaga gctgaactgt ctaatcaagg
     1021 ttcgaccttt catgtagcga ttcttctcag gatcgtcttt atgatagaca tagtaggagc
     1081 tagtttctct aataaaaact ttcaccttct cctcttcaat atcgagctgc atattcggca
     1141 caaagataag cccctcctga cgaataccaa acttgacctt gatgtaaata ccatcatcta
     1201 ctactttttc aatttgattg agtgacaact ctacctcaaa ctcatgaacg gcatctctgt
     1261 tgctcttgaa ctcttgatag aattcccaga acttctcatc tcttgggagt tctttttctt
     1321 tggaaaattt ttcttcttga taaaattgaa ccaaatcctc aatttctgga ttttgccaat
     1381 cttttctact ctcaaaataa tcttggaaaa attctacacc ataaagattt ttctggtcta
     1441 gttctgtctc tttcacctcc actcctgcca actggaaata cacatgcttt tgtttgggaa
     1501 tgatagttag atcaaaaagt ttcgcagttt caatcaagtc atctatattc tcagcctttg
     1561 ataagagaaa ttccatgagt tcttccattt cccttttggc aaagtaattc ttaaaaaatt
     1621 cttctgtata aggttgcttg cgattgagtt tattgccacg caccacctgt ttcatggatg
     1681 agtccgtcat aaaaaaggtc gcatgcttgt ggctaaaatc catttctaca tgtagtagtg
     1741 gagcattctt tttgaaatcc tcaaagtctc tagaatgttc catcaaaaaa tagagtcgct
     1801 gcttgagttc atacttgtga ttggtcttgc gataaacttc atactgctgg tgagaatagc
     1861 gattctctat aattttcgcc cctgcaattt tagaaaatct atctgaaatc attcgaagat
     1921 ttcgctccac tttataatcc cacttaagtt ttttgtcaga attgctgtca accgagttta
     1981 taatgatgtg attatgcaga tggtctttat caacgtgggt cgcaacgata aagcgaaact
     2041 ttccactagt caattctttc atggtctcat aaccaatctg attgatttgt tcaggagtga
     2101 gattgtcctc tggcgaaaag gactgaataa tatggtgagc atggatttgt cgttgtttct
     2161 cctccagcct atcgtgtcga aaattgtaaa gcgtgtcatt gttgataaaa ttttcatgat
     2221 acatctgcac catttcctca tagctaggaa agtccagaaa attcctcata tcataatccg
     2281 acactaaggt aagatttttt gttttatcag gattgagaat atacttgatg agctttctgc
     2341 gataactctt tccatgaatg gcaaaatgct tagtgatgac catggaactc cctcagcttt
     2401 tgagcttgta ttgtaaattc tttctcaact tcttttatca attcagcgat tccctttttc
     2461 aactcttgca attcttcgct agaaatcaac tgagattggt tcacacttcg agcaatctga
     2521 ttgatgttat tgccaatcct cttcaactca aacactaagt cttggtagcc atttgtatca
     2581 atggtgatga aattcattcc agggtcaagt agggtgcgtc tcgcatattc agaaaaagat
     2641 tggcagctac tttggtcgat atttctattt agttggttca actcaatatc agacaaaaac
     2701 actttcttga gattgattcg gtaacgatgt tccatgtgtc tacctcatat atttgtcttg
     2761 gaagtcttga ctgagaggaa tggagttgcc aacttcttta atcaattcct gtacgcaggt
     2821 taagagaata gatacatgtt cctgggtgac ttgacgttct gactggatcg aaattaaaat
     2881 ctcatgaaca tcacggctga tttgttctag tttttgagat tgccaaaggg tgaaccatat
     2941 ctctatctgt ttttgtaaat cagaggagag taaactttta cggagaaaat ctgaaaaatt
     3001 agtatctccc tgctctctca tcaaagctaa aatttgcttt tcctcttcat ctgttaggcg
     3061 aaattgtttt cgaatatcac gcacgtctcg tttcatacta ctacttcctt tccaaaatac
     3121 ctgtactgac aatgtctgct accgtacaat gtcagtacac ttttacacca actgattttc
     3181 attcttgtaa ggctttgcga gctcagatat tgtgtccaca atatcccaaa aatcatatcg
     3241 ccagctgact aaaaccttcc agttttgaca gctaacgata agataacttg gtggctccgc
     3301 ccccaaaccc ccatagaaaa tcaaaaattg attttctatg aatgatatta ggataacagg
     3361 gaagatttgg aaaagatatc acagctaata tagttatgat tgactttctc tgattctatg
     3421 ataaaatttc tgtaaactaa tatttggaga aataaaaatg ctgagtctag atcaaataca
     3481 tttactattg aatactcctg aagatgagtt tcatgatttt aaacaaaaat ggcatcattc
     3541 taaaactgaa ttggtgcgtg atatcttaaa ttttgtcaat acatcacatc atgaagattg
     3601 ttatatcatc tttggaattg ataatatcac tttagatata atcggtgtaa acaatgatga
     3661 taatagaaga aatgaagaag atctaacaga tttactacat aaactcttta tatcaacaaa
     3721 taatcaaatt agaattagca tacaaactga aactatagac aacaaagaaa ttgacatctt
     3781 aattattcat gatacagata aagttcctgt atttttaaca aaagattata agcctaagaa
     3841 agatactgca ttacaaaaag gattaatata tgctagaaat ggctctataa atactcctaa
     3901 agactcctct gctccatttg agttaataaa taagttgttt caaaagttta atcataccga
     3961 cttaaatatc aaagagcagt attttcatgt tttaaaagac tataaaaatt ggttcttcgt
     4021 tgaaaatgaa gacggaagat tttttattta taatcctaat cccgattttt atattaaact
     4081 taccgacgat gatgcaaatc gtttcaaaac tatgccttat agtttaaatc aataccaaac
     4141 caatgttgat tggcaattag tacaacttcg ttatcgacac cttacaatta tcgactttat
     4201 ggctttatat ttagatcagg gaaattgtct agtgccctcc cctgatttag aagattttga
     4261 atgtggttat tctgacacta tttattacca ctgtttatac aaaaatactt taaaatacca
     4321 attgctgaaa gttttctctt caatatctgg tctcgaaaaa tatcctttag atagatttaa
     4381 aaataatata gtaatttatg atgataaaat agaattggaa aagactcaca acttaataaa
     4441 aagtaatttt tcaacagaag agataatgaa gcaacttgaa gttacagaaa aagatttcga
     4501 tttttactat aaaaaagcta gacaaaaaaa tcc
//
LOCUS       DBERMM010000076         4301 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.078, whole genome shotgun sequence.
ACCESSION   DBERMM010000076 DBERMM010000000
VERSION     DBERMM010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4301)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4301)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4301
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.078"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(431..628)
                     /locus_tag="ACL8AS_002025"
     CDS             complement(431..628)
                     /locus_tag="ACL8AS_002025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HGS1229820.1"
                     /translation="MLATLESEARKKVGYLQVKTVAEGSNKDYDRTNDFYRGLGFKKL
                     EIFSQLWNPQNPCQILIKKLE"
     gene            complement(613..891)
                     /locus_tag="ACL8AS_002026"
     CDS             complement(613..891)
                     /locus_tag="ACL8AS_002026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family acetyltransferase"
                     /protein_id="HGS1229821.1"
                     /translation="MFVIEEVKDENQKKTVVAEVLKDLPEWFGIPESTQAYIEGTTTL
                     QVWTAYQESDLTGFVSLSYSSEDCAEIDCLGVKKLIKVEKLGANCLLL"
     gene            complement(930..1715)
                     /locus_tag="ACL8AS_002027"
     CDS             complement(930..1715)
                     /locus_tag="ACL8AS_002027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229822.1"
                     /translation="MKKYQRMHLIFIRQYIKQIMEYKVDFVVGVLGVFLAQGLNLLFL
                     NVIFQHIPFLEGWTFQEIAFIYGFSLIPKGMDHLFFDNLWALGQRLVRKGEFDKYLTR
                     PINPLFHILVETFQIDALGELLVGGILLGTTVTSIVWTLPKFLLFLVCIPFATLIYTS
                     LKIATASIAFWTKQSGAMIYIFYMFNDFAKYPISIYNSLLRWLISFIVPFAFTAYYPA
                     SYFLQEKDVFFNVGGLMLISLVFFVISLKLWDKGLDSYESAGS"
     gene            complement(1717..2535)
                     /locus_tag="ACL8AS_002028"
     CDS             complement(1717..2535)
                     /locus_tag="ACL8AS_002028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HGS1229823.1"
                     /translation="MIKLWRRYKPFINAGVQELITYRVNFILYRIGDVMGAFVAFYLW
                     KAVFDSSQESLIQGFSMADITLYIIMSFVTNLLTRSDSSFMIGEEVKDGSIIMRLLRP
                     VHFAASYLFTELGSKWLIFISVGLPFLSVIVLMKIISGQGIVEVLGLTVIYLFSLTLA
                     YLINFFFNICFGFSAFVFKNLWGSNLLKTSIVAFMSGSLIPLAFFPKVVSDILSFLPF
                     SSLIYTPVMIIVGKYDASQILQALLLQFFWLLVMVGLSQLIWKRVQSFITIQGG"
     gene            complement(2537..3529)
                     /locus_tag="ACL8AS_002029"
     CDS             complement(2537..3529)
                     /locus_tag="ACL8AS_002029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HGS1229824.1"
                     /translation="MAMIEVEHLQKNFVKTVKEPGLKGALRSFIHPEKQTFEAVKDLT
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQNNRQDYVKDIGVV
                     FGQRTQLWWDLALQETYTVLKEIYDVPDSLFHKRMDFLNEVLDLKDFIKDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLS
                     DIEQLCDRIFMIDKGQEIFDGTVSQLKETFGKMKTLSFELLPGQSHLVSHYDGLSDMT
                     IDRQGNSLNIEFDSSRYQSADIIKQTLSDFEIRDLKMVDTDIEDIIRRFYRKEL"
     gene            complement(3914..>4301)
                     /locus_tag="ACL8AS_002030"
     CDS             complement(3914..>4301)
                     /locus_tag="ACL8AS_002030"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229825.1"
                     /translation="IEINFTFPIDLFSSYFNPLYIMVSNLHQNDKINQLISDYKQNMK
                     AFYITIEKFIRDDESLKCYFIKVISSRSKVTSLDQIEADKTIQRKYSSELKNLLDFIM
                     RLFVRKIVSYMYERGGRVGLGSRCVS"
BASE COUNT         1444 a          918 c          740 g         1199 t
ORIGIN      
        1 aactagccgc aggttgctca aaacactgtt ttgaggttgt ggatagaact gacgtaatca
       61 gtaaccatac gcacggcaag gcgacgttga cgtggtttga agagattttc taagagtata
      121 agtccaaaac tttcgttaac cgggatacat tataagcaca ttcataccat caaaaatagt
      181 agcaataaac ttgaacaact accagaaaca cgaaaacagg cataattgat gaaatatcag
      241 cgctattaaa caatataaat aaccgctaag aataaggctt aacggttatc ttctacctat
      301 ctattttttc aactcctcag tcatttatct acctataacc taggctttac gagtgccttg
      361 ctctaccaac taagctaaat cggcgattac acttacagta tggcactctg agaatagatg
      421 tcaagtaata ttattcaagc tttttaatca aaatctgaca aggattttgc ggattccata
      481 gctgagaaaa aatctctaac tttttaaagc caagacctcg ataaaagtca tttgttcgat
      541 cataatcttt attagaacct tctgccactg ttttgacctg cagataacca acttttttac
      601 gagcttcact ctctaaagta gcaagcaatt ggctcccaat ttttctacct tgataagctt
      661 ttttacgccg agacaatcaa tctctgcaca atcttcactc gaataggata agcttacaaa
      721 tccagtcaaa tcactctcct gataggcggt ccaaacttgc agtgtcgtgg ttccttctat
      781 ataggcttgt gtgctttctg ggattccaaa ccattctggc aaatccttca aaacctcagc
      841 tacaactgtc tttttttgat tttcatcctt gacttcttca attacaaaca tcataagttt
      901 ctttcttgat tttagtctta ctttagcttt tacgaacccg cactttcgta ggaatctaag
      961 cccttatccc aaagtttaag ggaaataaca aagaaaacca gagaaatcaa catcaaacct
     1021 cctacgttaa agaacacatc cttttcctgt aagaaatagc tagctggata gtaggctgta
     1081 aaggcgaaag gcacgataaa gctaatcaac caacgaagaa gagaattgta aatagaaatc
     1141 ggatacttag caaagtcatt gaacatatag aagatgtaaa tcatggcgcc tgactgctta
     1201 gtccaaaagg cgatactggc tgttgcgatt ttaagagaag tataaatcaa ggtcgcaaaa
     1261 ggaatacaaa ctaggaaaag caggaatttt ggaagagtcc aaacaatgct ggtcactgtt
     1321 gttcccaata aaataccacc gactaagagt tcacccaagg catcaatctg aaaggtttca
     1381 actaggatgt gaaagagagg attgatggga cgagtcagat acttgtcaaa ctctcctttt
     1441 cggactaggc gttgccctag tgcccagaga ttgtcaaaaa agagatggtc cattcccttg
     1501 ggaatcaagg aaaatccata aatgaaagct atctcttgaa aggtccagcc ttctaggaat
     1561 ggaatatgtt gaaagatgac attgagaaac aagagattca agccttgagc cagaaagact
     1621 cccaagacac caaccacaaa atccacctta tattccatga tttgtttgat gtattgtctg
     1681 ataaaaatca gatgcattcg ttgatatttt ttcatactaa cctccttgaa tggtgataaa
     1741 ggactggacc cgtttccaaa ttaactgaga caatcccacc atcactaaga gccagaagaa
     1801 ctgcaaaagg agtgcctgaa gaatctgact ggcatcgtat tttccaacaa tgatcataac
     1861 tggagtataa atcaaggatg aaaaaggcaa aaaggagaga atatctgaaa caacctttgg
     1921 aaagaatgcc aagggaatca aactccccga cataaaagcc actatggaag tcttaagtag
     1981 gttggaaccc caaagatttt taaacacaaa ggctgaaaat ccaaagcaaa tattaaagaa
     2041 aaagttaatc agataggcga gcgttaagct aaaaagataa atgacagtta atcctagcac
     2101 ctctacaata ccttgacccg atatgatttt catcaagaca atgacactta aaaatggaag
     2161 gccaacgctg ataaaaatca accacttgga accaagctcg gtgaaaagat aggaggccgc
     2221 aaaatgcact ggtcgcaaca aacgcatgat aatggagcca tccttgacct cctccccaat
     2281 cataaaggac gaatcggatc tagtcagaag attggtcaca aaactcatga tgatgtagag
     2341 ggtgatatcc gccatactaa agccctgaat caaagactct tgcgaagaat caaagacagc
     2401 cttccagaga taaaaggcca caaaagcccc catgacatcg ccaatccgat agagaataaa
     2461 gttgactcgg taagtaatca actcctgaac ccctgcattg ataaagggtt tataacgtct
     2521 ccacaatttg atcatcctag agctcctttc ggtagaagcg acggataata tcctcaatat
     2581 ccgtatccac catcttcaaa tcgcggattt caaaatcaga cagggtttgc ttgataatgt
     2641 cagctgactg gtagcgagaa ctatcaaatt caatgttgag gctgtttcct tgtctatcaa
     2701 tggtcatatc agacagaccg tcatagtgag agacgagatg actttgacct ggtagcagtt
     2761 caaaagagag agtcttcatc ttaccaaagg tctccttgag ttggctcacc gttccatcaa
     2821 aaatctcttg ccccttgtca atcatgaaaa tccgatcaca aagttgctca atatcactca
     2881 aatcgtgagt ggtcaaaaga atggtagttt cttcctcttg attgatctga gtaattgccc
     2941 gacgaatatt atccttaacc gaaacgtcca aaccaatggt cggctcatct aaaaaaagaa
     3001 ccttgggatt gtggagcaag gaggccgcaa tatccgcccg catccgttgt cccagtgaaa
     3061 gagtccgcac gggatccttg ataaagtcct tcaaatccaa gacttcattc aaaaagtcca
     3121 tacgcttatg aaagagcgag tctggcacat cataaatctc ttttaagaca gtgtaggtct
     3181 cttgcagagc caaatcccac catagctggg tgcgttgtcc aaagactacg ccaatatctt
     3241 tgacataatc ttgccgattg ttctggggaa tcttgccgtt aatccgacaa aaaccagatg
     3301 ttggtttcaa aattcctgtc agcattttaa tggttgtcga cttcccagca ccatttgccc
     3361 cgataaatcc taaaatctgc ccttttggaa cttcaaaggt caaatccttg accgcttcaa
     3421 aggtctgctt ttcaggatga ataaaggagc gcaaagcccc cttcaagccc ggttccttaa
     3481 cagtcttcac aaaatttttc tgaagatgtt ccacttctat cattgccata tctatctccc
     3541 tatcataagg aatagcaaca ttgtgttttt aactacaaat attctaaatc cttactttct
     3601 acaccttcta cattttatta ctacagaaga ctttatacca acctattata gtccaataaa
     3661 aaacagaatg caagcgtttg cctatggatt gtgaaattag gatttctctc atgaaataat
     3721 acttttaatc aaaaattctg tttaatagtt taaattacca acctactcat cttctcacca
     3781 gagggcggta ttaactttga tcataaaatc ggatactccc tctatccaga aaatatgctc
     3841 agaatgattg tctctaaaca atacctgctc ttttacctca ttcatgaaaa agaagtccat
     3901 accctgagaa ttatcaactc acgcaccgac tacctaaacc aactcgacca cctctttcgt
     3961 acatgtagga aactattttc ctcacaaata atctcattat aaaatccaat aaatttttta
     4021 gctcacttga atattttctt tgtatcgttt tatcagcttc aatctgatct agacttgtta
     4081 ccttggaacg acttgaaata acctttataa aataacactt aaggctttca tcatctcgta
     4141 taaatttttc aatagtgata taaaaagctt tcatattctg tttataatca gatattaatt
     4201 gattaatttt atcattctga tgaagattcg ataccataat atatagcgga ttgaaataag
     4261 atgagaacaa atcgattggg aaagtaaaat taatttctat a
//
LOCUS       DBERMM010000077         3631 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.079, whole genome shotgun sequence.
ACCESSION   DBERMM010000077 DBERMM010000000
VERSION     DBERMM010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3631)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3631)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3631
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.079"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(247..402)
                     /locus_tag="ACL8AS_002031"
                     /pseudo
     CDS             complement(247..402)
                     /locus_tag="ACL8AS_002031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
     gene            complement(579..1190)
                     /gene="rpsD"
                     /locus_tag="ACL8AS_002032"
     CDS             complement(579..1190)
                     /gene="rpsD"
                     /locus_tag="ACL8AS_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0019843 - rRNA binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HGS1229826.1"
                     /translation="MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKL
                     SEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRL
                     GLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATL
                     GRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML"
     gene            complement(1385..2437)
                     /locus_tag="ACL8AS_002033"
     CDS             complement(1385..2437)
                     /locus_tag="ACL8AS_002033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000769768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HGS1229827.1"
                     /translation="MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTI
                     VASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEM
                     SHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
                     TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERR
                     DVHLQVIPESARIEGDYAKLSRILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTD
                     EGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGEITVSSQYGLG
                     STFTLVLNLSGSENKA"
     gene            complement(2434..3132)
                     /locus_tag="ACL8AS_002034"
     CDS             complement(2434..3132)
                     /locus_tag="ACL8AS_002034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000520636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HGS1229828.1"
                     /translation="MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKK
                     KPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFITAKTSEQDKIYGLSLGADDFIA
                     KPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
                     LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTV
                     WGLGYKIEKPRGQT"
     gene            complement(3299..>3631)
                     /locus_tag="ACL8AS_002035"
     CDS             complement(3299..>3631)
                     /locus_tag="ACL8AS_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HGS1229829.1"
                     /translation="INVKETSDTANGSLSPSNSGSGVTPMNHNHATGTTDSMPADTMT
                     SSTNTMAGENMAASANKMSDTMMSEDKAMLPNTGETQTSMASIGFLGLALAGLLGGLG
                     LKNKKEEN"
BASE COUNT         1040 a          783 c          685 g         1123 t
ORIGIN      
        1 aaatcgttct atagtaaaat gaaacaagaa caggacaaat cgatttctaa caatgtttta
       61 gaagtagagg tgtactattc tagtttcaat ctattatatt tcgtctgatg ggcaaatctt
      121 ataaagagat tatagagctt ttatagtgat ttgaaataag atgtgaacaa ctctatcagg
      181 aaagtcaaat taatttatag aaatatttta gcagccaagg tgtactgtta tagattcaat
      241 acactatact tggtggttta gctctcctgt tttctctttt agctttaacc agccataaat
      301 ggtattacgt gagatttgga aaacgtgtga tgcttctgtt atactatctg ttcactcaca
      361 ataagagaga acttttttac gaaaatctat tgaatattcc ataaaagatt ataccacatt
      421 gtgtactatt tttggttcat tttactatat cactttggac tatatcggtc tagttatgtc
      481 taaacgatta tagctggata ctaagagaaa tcaaaaaagc actaagggag aacgtcccaa
      541 agtgcttaat atcaaagcct atcttattca ataaaatatt acaacatttt gttgtagaat
      601 tcaacgacaa gtgcttcgtt gatttctggg ttgatttcgt cgcgttctgg caagcgagtc
      661 aatgaacctt ccaatttttc agcgtcgaat gatacgaatg ctggacgtcc aagagtagct
      721 tctactgctt caaggattgc tggaactttc aatgattttt cacgaactga gatcacttga
      781 cctggagtta cgcggtatga tgggatatca acgcgtttcc cgtcaacaag gatgtgaccg
      841 tggtttacga attgacgagc ttgacgacga gtagtcgcga gaccaagacg gtaaacaacg
      901 ttatccaaac gacgttccaa aagaagcata aagttgaaac ctaggattcc gcctttgatt
      961 tttgtagctt gtacgaacaa gttacggaat tgtttttcac ctacaccgta agtgaaacga
     1021 agtttttgtt tttcagccaa ttgcaaaccg tattctgaca atttagaacg gttgtttggt
     1081 ccgtgttgtc ctggtacgta gttacgacgt gccaattctt tacctgtacc tgtaagtgaa
     1141 aggccaaggc gacgagcttg tttccaagat ggtcctgtat aacgtgacat atgaatgtcc
     1201 tcctgatata aataatattt cggtggaaat agtcacttag aaagccctga ttcgtgcaga
     1261 tgcccttcgc ctaaacagcc aaggttactt gtcataagac acctgttgac gagcttcatg
     1321 ctttcctgct gatatttcac acaaaatcta ttctaccatg aatagctgga tttgtaaagg
     1381 ggttttaggc tttattttca ctaccagaga ggttgagaac gagggtaaag gtacttccta
     1441 gaccgtactg gctgctgact gtgatttccc cacccaattg atgggccaat tcacgcgcaa
     1501 tcgcaagtcc taatccatga ccacctgtct tcatgttacg cgaagtttcg acacgataaa
     1561 ggcgtttgaa aatattttcc aaatcctctg gggcaatacc ctgcccttca tcggtcacac
     1621 tgattgaaag ctggtccttc tccagcttag ccaccacttc cagcttggtt cctggagcag
     1681 aatatttaaa agcgttatcg accagattca ccaagatacg agaaagctta gcataatctc
     1741 cctcaatccg ggcagactct gggattacct gcaagtggac atctcttctc tcctgctcaa
     1801 tcaaaaactg aaattcactc atgcactcaa ttaagagctt gtccagaaaa atactgtctt
     1861 tactggtagt ttccacctga tttctagctg tgtttagggt caaaaaattc aactcctcaa
     1921 ccagtttatt gagcctctcc gtctggcgtc caatggttgc tagataatga gcttgctccg
     1981 actccttgat aatcccatcc aaaatccctt ctaccgtcgc ttggatcgaa gtgataggag
     2041 tcttaatatc atgcgacaac tgagcaatca tcaagccctt ttctcgttcg ctttcttcca
     2101 aggaatcaaa gcttacctgc aaatcatggg acatctcatt aaaagtttgc cctaattgct
     2161 gaaattctac aggaccttga acctccaaat ttgaaggaaa atccttggcc gctacccgct
     2221 tggcatgctc cttgagtttg cccaacgacg taaagactgg caataggaga aagagactaa
     2281 tcccagcacc gacaaggctg gcaacgatgg tcatcccaag caaaaagtaa atctcgcctt
     2341 tcgcaatcag cattttttga acagcccaaa aaacaaccaa aatggttaag agggttgaaa
     2401 taatatatcc aaccaaaata taacttttta gtttcatgtt tgtcctctcg gtttctctat
     2461 cttatatccc aacccccaaa ctgtcttaat agtgggcgtt tggtcactac tatattttgc
     2521 cagctcctgt cgaagagcat ggatatgcac attcaaggta ttggtgtcat ccacgtagtc
     2581 ttctttccag atcttttcat agaggtctgt cttggagaaa actcgctctg gattgctagc
     2641 taaaatccac agcaattcaa atgatttaac agttaaatcc agcatttctt ctcctatttg
     2701 aacttcatga ctactatgat tcatttttag attgccaagg gaaatcagct ctgtttcgcc
     2761 cccacgatga aggcggcgca aaatattgtg gacacgcaaa accagctcac gtgggctaaa
     2821 aggcttagca ataaaatcat ctgctcccaa gctcaggccg taaatcttgt cctgttcact
     2881 ggtcttagca gtaataaata ggaaaggctg ctctggtgat aagtattgaa cctcactgat
     2941 taaatcataa ccatccatcc gaggcatcat gacatctgtg ataatcaaat caatcggttt
     3001 tttcttgaac agctctagcg cttccagtcc atcatgggct accaagacct gataacctgc
     3061 ctgaattaag tatctctgat gaatatctgt gatttctacc tcgtcgtcaa cgagtaaaat
     3121 tgtctttccc atctgtctct cctttgataa aaacagtgct atactgcttt aagtataaca
     3181 ctatttttat tgttttacga tgattttaat ctgctattga aagaaagtcc tgattgctga
     3241 ttgagttgtt aaactaatct tagtcagccc actatccatc atttatttcc ttagctgatt
     3301 agttttcttc ttttttgttt ttcaaaccta gaccaccgag taaacctgca agcgcaagcc
     3361 caaggaaacc aatacttgcc attgatgttt gagtctcacc agtatttggt agcatagctt
     3421 tatcctctga catcatcgta tcagacatct tgttagcaga agcagccatg ttttcacctg
     3481 ccatcgtgtt ggtagaactt gtcatggtgt cagcaggcat gctatctgta gtacctgtag
     3541 catgattgtg attcatcgga gtcacgccag aaccagagtt agaaggtgat aatgaaccat
     3601 ttgctgtgtc tgatgtttct ttaacattta t
//
LOCUS       DBERMM010000078         3413 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.080, whole genome shotgun sequence.
ACCESSION   DBERMM010000078 DBERMM010000000
VERSION     DBERMM010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3413)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3413)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3413
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.080"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(376..1569)
                     /locus_tag="ACL8AS_002036"
     CDS             complement(376..1569)
                     /locus_tag="ACL8AS_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008293041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008754 - O antigen ligase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen ligase family protein"
                     /protein_id="HGS1229830.1"
                     /translation="MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIIS
                     LIFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQS
                     ILSHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFF
                     NPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAG
                     AIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMAL
                     FKQNPFWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRL
                     MMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLV
                     SDMTD"
     gene            complement(1707..3149)
                     /gene="gtfA"
                     /locus_tag="ACL8AS_002037"
     CDS             complement(1707..3149)
                     /gene="gtfA"
                     /locus_tag="ACL8AS_002037"
                     /EC_number="2.4.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004645 - 1,4-alpha-oligoglucan
                     phosphorylase activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose phosphorylase"
                     /protein_id="HGS1229831.1"
                     /translation="MPIQNKTMLITYSDSLGNNLKDLYDNLEEHFGDAIGGVHLLPFF
                     PSTGDRGFAPVDYDEVDSAFGDWEDVKRLGERYYLMFDFMINHISRQSKYYKDYQEKH
                     EASEFKDLFLNWDKFWPENRPTQSDVDLIYKRKDRAPKQEIVFEDGSVEHLWNTFGEE
                     QIDLDVTKEVTMEFIRKTIQHLASNGCDLIRLDAFAYAVKKLDTNDFFVEPDIWDLLD
                     KVRDIAAEYGTELLPEIHEHYSIQFKIADHDYYVYDFALPMVTLYTLYSSRTERLAKW
                     LKMSPMKQFTTLDTHDGIGVVDVKDILTDEEIDYASNELYKVGANVKRKYSSAEYNNL
                     DIYQINSTYYSALGDDDVKYFLARLIQAFAPGIPQVYYVGLLAGKNDLKLLEETKEGR
                     NINRHYYSNEEIAKEVQRPVVKALLNLFSFRNRSEAFDLEGTTEIETPTAHSIVIKRQ
                     NKDKSVTAVVEIDLQNQTYRVIENGVEVSF"
BASE COUNT         1146 a          746 c          532 g          989 t
ORIGIN      
        1 tactatgtct tttcacacca accttattcc gaattcaatt acttttgtga tttacatata
       61 tagattaaga ctatctttta tactttaaaa tttctcgcta ccttatccac tatatgctcc
      121 tcgctatcac gtttctattc atagcctacg atttcactat tgctttctct gacaattctt
      181 atttcctgcg tcagacttaa aacgatctat ccccagacca ttttaatccg ctacctcacg
      241 atagtcaggc ttggggagcg ctattgtatt caccggtagt ggatccctac agaggactta
      301 cacctcagat gcacgacatg cccatcgtat aaaaaaatct cctacccaag gtagaagatt
      361 tcaaacttat aaaacttaat ccgtcatgtc cgataccaac attcgatgct ccaatggaat
      421 actgcacata actagcaaga aaataaagcc tgactgaatc cagaagagag ccaagtcaaa
      481 aattccgtgc acagcaacca ctgtaaggaa agatagataa aggccgataa tcggacgttt
      541 ccccgactcc tgactcatat ccatcatcaa gcgaacagga gcaacagaag acaaaactaa
      601 taaaatggta cccacaattc cgtaactcag aatcgtatca atataaagac tgtgggcatg
      661 ttcatgataa ggagcatgta tccgaggata agagtgcata taggtcaatg gcccttcacc
      721 ccaaaaagga ttttgcttaa acaaggccat cccagcatcc cagatagaaa tgcgttcttc
      781 catagaagag tctaaagtac ccattcgaac tcccaaatca ctagaaaaga ggaaactcaa
      841 accaatcgcg aagaccccaa tactaagcca aaaggccttc cagtttttaa tagtcgtaaa
      901 gagatagata attgctccag cgataatagc aggaaaggca gttcgatttt gagtaaagtt
      961 caaaccaaag agattaacaa agcctgcaat cacacagaat actttcaacc aattcaactt
     1021 ggtcgttgta aacagataga aagcaatcat aatacagaaa caacaaataa ttccataata
     1081 attaggatta aagaaggtca cttctgcccg gttctgatgc cacacctgca tattgggtga
     1141 aagaaaagca tagttaaatt tcttcacaat ttggaaatgt tctaaactgg caaaagcagc
     1201 tgacaagaca ctaccaaaca agacgaactg caaaatcaat cgaaagaatt tatgggataa
     1261 aatcgactga tagtgcaaaa agaaaatagt aaatagaaac attcctactg aagccacaag
     1321 acccatccaa ttttgtgcaa gaatggatat aacagtacta tagctaagaa aaagaagcag
     1381 catcggatgc tcccccattt tctgaagaat acttttcatg tctcctgtaa aaatcaaact
     1441 gataatatat aaacagagta caactacaaa aagataaaag ggtaaaaaga tacttaggat
     1501 aattcccaat aaaatcagct ctttactaga caaccccttc agcttttcaa taaagcctat
     1561 tgatttcaaa atgaatcctt tctctccaaa tcagctgatt cagataatag taagctatcc
     1621 tatattgtac cactttttta gcaatttgaa aacaaaggaa acgttttcca aaataaaaac
     1681 cctattttat ccaccatatc aaggcttcaa aatgatactt caactccatt ctcaattacc
     1741 cgataagtct gattttgcaa atcaatttct actactgctg ttacggactt atctttattt
     1801 tgacgtttga ttacaatgct gtgagctgtt ggtgtctcta tctcagtagt cccttctaga
     1861 tcaaaggctt ctgaacggtt acggaaagaa aatagattga gaagggcctt cacaacaggt
     1921 cgttgcactt cttttgctat ttcctcgttg ctatagtaat gacgattaat atttcgacct
     1981 tctttagttt cttctaataa tttcaagtca ttcttgcctg ctaatagacc cacatagtaa
     2041 acctgaggaa tacctggggc aaaagcttga attagacgag cgagaaaata cttgacatca
     2101 tcatctccaa gcgctgaata gtaggttgaa ttgatttggt agatatctaa gttgttatac
     2161 tcggcactag agtacttacg tttgacattg gctccaacct tatagagttc atttgaagca
     2221 tagtcaatct cctcatcggt caggatatcc ttgacatcta ctactccaat cccatcatgg
     2281 gtatctagcg tcgtaaattg cttcatcggg ctcatcttta accacttagc caaacgctct
     2341 gttctggaac tgtaaagagt ataaagtgtc accattggaa gagcaaaatc ataaacatag
     2401 taatcatggt ctgctatttt aaactgaatc gaatagtgtt catgaatctc aggtaaaagc
     2461 tctgtcccat actcggcagc gatatctcga actttgtcca ataaatccca aatatctggt
     2521 tccacaaaga aatcattagt atccaatttc ttcactgcat aagcaaaggc atctagacga
     2581 atcaaatcac acccattact tgccaagtgc tgaatggtct tacggataaa ttccatagtt
     2641 acttctttgg tcacatcaag atcaatctgc tcctcaccaa aggtattcca caaatgttcc
     2701 actgaaccat cttcaaacac aatctcttgc tttggtgcac gatccttacg cttgtaaatt
     2761 aaatctacat cagactgtgt cggacggttt tctggccaaa acttatccca gtttaaaaag
     2821 agatctttaa attcactggc ttcatgtttt tcttgatagt ccttataata cttggattga
     2881 cgagaaatat gattaatcat aaaatcaaac ataagataat atctctcacc taaacgctta
     2941 acatcctccc aatcaccaaa agctgagtcc acttcgtcgt agtcaactgg cgcaaatcca
     3001 cgatcacctg ttgatgggaa aaatggtaaa aggtgaactc ctccaatagc atctccaaaa
     3061 tgctcttcca aattatcata taagtcttta agattatttc caaggctatc agaataggta
     3121 atcaacatgg ttttattttg aattggcatc attactctcc tttttctaat tgaagccaag
     3181 tctcatatga tctggcttcg taaatcaaat tcattttaaa tctctattta tcatcaaact
     3241 cgtactaata tagactgtga taaacaaagt actactttct tgttttctac atagaattat
     3301 caacaagctg aactcttcct ctgtgtcaaa gactatagat tccatgagct cttcttatac
     3361 tattcgaaaa tctcttcaaa ccacgtcagc gtcgccttac cgtaggtatg gtt
//
LOCUS       DBERMM010000079         3096 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.081, whole genome shotgun sequence.
ACCESSION   DBERMM010000079 DBERMM010000000
VERSION     DBERMM010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3096)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.081"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            52..579
                     /locus_tag="ACL8AS_002038"
     CDS             52..579
                     /locus_tag="ACL8AS_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HGS1229832.1"
                     /translation="MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQI
                     GALTAVFSLRESFDESVHFGTSRILGNSIGGLYALVFFLLNTFFHEAFWVTLVVVPIC
                     TMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETISYVFVRVSETFMGVFVAIIVN
                     YDIDRIRLFLEKKEK"
     gene            656..1012
                     /gene="glnR"
                     /locus_tag="ACL8AS_002039"
     CDS             656..1012
                     /gene="glnR"
                     /locus_tag="ACL8AS_002039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000659547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor GlnR"
                     /protein_id="HGS1229833.1"
                     /translation="MKEKEFRRNMAVFPIGSVMKLTDLSARQIRYYEDQELIKPDRNE
                     GNRRMYSLNDMDRLLEIKDYISEGYNIAAIKKKYAEREAKSKKAVSQTEVRRALHNEL
                     LQQGRFASVQSPFGRG"
     gene            1049..2395
                     /gene="glnA"
                     /locus_tag="ACL8AS_002040"
     CDS             1049..2395
                     /gene="glnA"
                     /locus_tag="ACL8AS_002040"
                     /EC_number="6.3.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004356 - glutamine synthetase activity
                     [Evidence IEA];
                     GO_process: GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="HGS1229834.1"
                     /translation="MPITAADIRREVKEKNVTFIRLMFSDILGTMKNVEIPATDEQLD
                     KVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEG
                     EPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDL
                     APTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLV
                     VKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAY
                     HFLGGLIKHAYNYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGT
                     RLELRSVDPMANPYVAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDL
                     PSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY"
     gene            complement(2491..2610)
                     /locus_tag="ACL8AS_002041"
     CDS             complement(2491..2610)
                     /locus_tag="ACL8AS_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HGS1229835.1"
                     /translation="MPDIVFEIEFFHSDSLIFFYTSDDKSNSQKSQEDFSKNK"
     gene            2575..2724
                     /locus_tag="ACL8AS_002042"
     CDS             2575..2724
                     /locus_tag="ACL8AS_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope"
                     /protein_id="HGS1229836.1"
                     /translation="MEKFNFKNNIGQENKLLQIEIYKFTNFYKLQNYTSVNIFSKDIF
                     EAIVN"
BASE COUNT          951 a          544 c          637 g          964 t
ORIGIN      
        1 actcataaaa atcaccgatt tatgataaaa tggaaataga aagttgagat tatgagttat
       61 tttaaaaaat ataaattcga taaatcccag ttcaaacttg gtatgcgaac ctttaaaaca
      121 ggtattgctg tttttctagt tctcttgatt tttggctttt ttggctggaa aggtcttcaa
      181 attggtgctt tgacagccgt ttttagcctg agggagagtt ttgatgagag tgttcatttt
      241 gggacttcgc gtattctagg aaatagtatc ggtggactct atgccttggt cttcttctta
      301 ttaaatacct ttttccacga agccttttgg gtgaccttgg tagttgttcc aatctgcacc
      361 atgttaacca ttatgacaaa tgtagccatg aataacaaag caggggttat tggtggtgta
      421 gcagctatgt taatcattac cctatcaatt ccaagtggtg agacaatttc gtacgtgttt
      481 gtgcgtgtat cagaaacgtt tatgggagtt tttgtcgcaa ttatcgtaaa ttacgatatt
      541 gatcgtattc gtctcttttt agagaaaaaa gaaaaataat gttacatttt ataacattat
      601 caattgacgt ttgtcttttt ttagactata atagacagaa agaaggaaat tgtaaatgaa
      661 ggaaaaagaa tttcgccgaa atatggctgt ttttcctatt ggcagtgtta tgaagttgac
      721 cgatctatcg gcgcgtcaga ttcgttatta tgaagatcaa gagttgatca agcccgatcg
      781 aaacgaagga aatcgtcgca tgtattcctt gaatgacatg gatcgtctgc ttgaaatcaa
      841 agattatatc tctgaaggtt ataatatcgc tgccattaag aaaaaatatg ctgaacgtga
      901 agcgaaatcc aagaaagcgg ttagtcagac tgaagtacgt cgtgcacttc acaatgaact
      961 cctccaacag gggcgttttg cttcagtaca gtcacctttt ggtcgcggtt aggcaaccgc
     1021 aagtagtcat agattaagga gaaaacttat gccaatcaca gctgcagata ttcgtcgtga
     1081 agtcaaggaa aaaaatgtta cctttattcg tcttatgttc tcagatattt tgggaaccat
     1141 gaaaaacgtc gaaattcctg ctacagatga acagttagat aaggtcttgt cgaacaaggt
     1201 tatgtttgat ggatcttcta ttgaaggttt tgtacgtatc aatgagtcgg atatgtactt
     1261 gtacccggac ttggatacat ggacagtctt cccttgggga gatgaaaatg gaagtgttgc
     1321 aggtctgatc tgtgatgttt atacaacaga aggtgaacca tttgcgggtg accctcgtgg
     1381 taatttgaaa cgagctcttc gtcacatgga agaagttgga ttcaaatcct tcaaccttgg
     1441 tccagagcca gaattcttcc tatttaagtt ggatgaaaat ggggacccaa cacttgaagt
     1501 gaatgacaag ggtggctact ttgatttggc acctactgac cttgcggaca acacacgtcg
     1561 tgagattgtg aatgtcttga ccaaaatggg atttgaagta gaagcgagtc accacgaggt
     1621 tgcggttgga cagcatgaga ttgactttaa gtacgatgaa gttctccgtg cttgtgataa
     1681 gattcaaatc tttaaacttg ttgttaaaac cattgctcgc aaacacggac tttacgcaac
     1741 atttatggcg aagccaaaat ttggtattgc tggctcaggt atgcactgta atatgtcctt
     1801 gtttgatgca gaaggaaata acgccttttt tgatccaaat gatccaaaag gaatgcagtt
     1861 gtcagaaaca gcttaccatt tcctaggcgg tttgatcaag catgcttaca actatactgc
     1921 catcatgaac ccaacagtta actcatacaa acgtttggtt ccaggttatg aagcgcctgt
     1981 ttacattgct tgggctggtc gtaaccgttc gccacttgtg cgcgtacctg cttcacgtgg
     2041 tatgggaact cgtcttgagt tgcgttcagt ggatccaatg gcgaaccctt acgttgctat
     2101 ggctgttctt ttggaagttg gtttgtatgg tattgaaaat aaaatcgaag caccagctcc
     2161 tatcgaagaa aatatctaca tcatgacagc agaagagcgc aaggaagctg gtattacaga
     2221 ccttccatca actcttcaca acgctttgaa agctttgaca gaagatgaag tggttaaagc
     2281 tgctctcgga gatcacatct acactagctt ccttgaagcc aaacgaatcg aatgggcaag
     2341 ttatgcaacc ttcgtttcac aatgggaaat tgataattat ttagaccttt actaatacta
     2401 atatagaaga aagattgcct gtgggtaaac agtcacacag cagtctaagc catcaaatac
     2461 ctataaccct taaaatagcg atttcggtcg ctatttattt ttcgaaaaat cctcttgact
     2521 cttttgcgaa ttagatttat catcagacgt gtagaagaaa atcaaggagt cactatggaa
     2581 aaattcaatt tcaaaaacaa tatcgggcaa gaaaacaagt tacttcaaat cgaaatctac
     2641 aagtttacta acttttacaa gcttcaaaat tacacatctg taaatatttt ttcgaaagat
     2701 atatttgaag ccatagtaaa ttgagactag aatagtacac tacatctgct aaaaatttct
     2761 agaaactaat ttaactttcc taatcgattt gtttacatct tatttcaatc tactatatta
     2821 tctcaataaa tgatgatggc gactgttttg tttgtgcttg tcgatttttg aatccctgat
     2881 cgagcggaag aatatttctg ccgaggttgc caaggggaaa atactgaaga tattgaattt
     2941 tatgatgaac aattacaggc agaaaaggtg gaggttttga atattcgatt ggaagtaaaa
     3001 aattgaatta tctacaatct catcaacaat aaacctattt caaccccatt atctataggc
     3061 gtatttttac gcctttttat atacttgaag cacata
//
LOCUS       DBERMM010000080         2981 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.082, whole genome shotgun sequence.
ACCESSION   DBERMM010000080 DBERMM010000000
VERSION     DBERMM010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2981)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.082"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(81..542)
                     /locus_tag="ACL8AS_002043"
     CDS             complement(81..542)
                     /locus_tag="ACL8AS_002043"
                     /inference="COORDINATES: protein motif:HMM:NF013842.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
                     /protein_id="HGS1229837.1"
                     /translation="MGKERREQGNLERKKRVVKKRKIPLEELKAFVEAHPDAFLREIA
                     ARFDCALPSVWAVLKQIKVILKKTTSFREQKPEKVSEFLDILDNLKDLPVLYIDETGI
                     NRYLYRPYAGAPRGEKVYDKISGRRFERTNEVEQKLNGSFLIRYIDSQIRE"
     gene            complement(509..652)
                     /locus_tag="ACL8AS_002044"
     CDS             complement(509..652)
                     /locus_tag="ACL8AS_002044"
                     /inference="COORDINATES: protein motif:HMM:NF013842.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
                     /protein_id="HGS1229838.1"
                     /translation="MAYSTDFKQGALDSIKEGHRHVEAAKVFDVGVRTLFTWEKKDVN
                     KGT"
     gene            921..1301
                     /locus_tag="ACL8AS_002045"
     CDS             921..1301
                     /locus_tag="ACL8AS_002045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HGS1229839.1"
                     /translation="MTYLEKWFDFNRRQKEIESLLEETIAQQSEQSLTLKEFYLLYYL
                     DLAEEKSLRQIDLPDKLHLSPSAVSRMVARLEAKNCGLLSRMCCHQDRRSSFICLTND
                     GQKTLASLQKTVEESLEAGLDFLI"
     gene            1400..1621
                     /locus_tag="ACL8AS_002046"
     CDS             1400..1621
                     /locus_tag="ACL8AS_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HGS1229840.1"
                     /translation="MIEITYIDASKNERTVTFESYEDFERSQQACLIGVADYYPVQKL
                     TYKGHNLDYHGTYGDIFFYLMKQDLSQYN"
     gene            1638..1952
                     /gene="trxA"
                     /locus_tag="ACL8AS_002047"
     CDS             1638..1952
                     /gene="trxA"
                     /locus_tag="ACL8AS_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003004519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HGS1229841.1"
                     /translation="MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEE
                     LSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAE
                     LS"
     gene            2260..2793
                     /gene="queF"
                     /locus_tag="ACL8AS_002048"
     CDS             2260..2793
                     /gene="queF"
                     /locus_tag="ACL8AS_002048"
                     /EC_number="1.7.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0033739 - preQ1 synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046857 - oxidoreductase activity, acting
                     on other nitrogenous compounds as donors, with NAD or NADP
                     as acceptor [Evidence IEA];
                     GO_process: GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preQ(1) synthase"
                     /protein_id="HGS1229842.1"
                     /translation="MKRQSALVVFSGGQDSTTCLFWAMQHYETVEAVTFAYGQHHHLE
                     IQIAREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFSY
                     RNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNYGKQGTKYEGLA
                     EQRLFQHDLYPEKIDNR"
BASE COUNT          931 a          617 c          564 g          869 t
ORIGIN      
        1 gttttttata aagacacgca aatgagtata aatcagctaa tttttggttt acatttctat
       61 ttttgtgcat aattattctg tcattctcta atttgtgaat caatatatct gattagaaaa
      121 ctaccattga gtttttgctc cacctcatta gtccgctcaa aacgccgtcc gctaatcttg
      181 tcatagactt tctcccctct aggagcccct gcataaggac gatagaggta gcggttgatt
      241 cccgtttcgt caatatatag gactggtaaa tcttttaggt tatccaaaat atcaagaaac
      301 tcagaaactt tctcaggctt ttgttcccta aaactggtcg tcttttttaa aatgacctta
      361 atctgcttta aaactgccca tacggagggc aaagcacaat caaaacgggc cgcaatttcc
      421 cgtaaaaaag cgtctggatg agcctctaca aaggctttca attcttctaa agggatctta
      481 cgctttttga cgactcgctt tttcctctct aagttccctt gttcacgtct ttcttttccc
      541 acgtgaagag agttctgacg ccgacatcaa aaactttggc cgcctcgaca tgtctgtgcc
      601 cctctttgat ggaatctaat gctccttgtt taaaatcagt actatatgcc atagctttat
      661 tagaccatgc ttattttaaa ctaagcaact atagatagag aaatgaaata aaatctgaat
      721 tcgaatgtga taaggagtta gaaattgaaa caataggatt cccccattat tcacacaaaa
      781 ataaaaccac taaaaaacag agcttgccag cattcttgaa aagtagtata attattgcat
      841 gcgcaatcat cttgtgacgc agagactgcc cgttaatgga ctttcttcta ttttatgact
      901 ctaaaaagaa aggagacact atgacctatt tggaaaaatg gtttgacttc aatcggcgtc
      961 agaaagaaat tgaaagtctc ttggaagaga ccattgccca acagagcgag caaagtctga
     1021 ccttgaaaga gttctacctg ctctactatc tggacttggc tgaagaaaaa tctctacgcc
     1081 agattgacct gccagataag cttcatctga gcccgagcgc agtttctagg atggtggctc
     1141 gcttggaagc taaaaattgc ggtctactca gtcgcatgtg ttgccatcaa gatagacgct
     1201 ctagttttat ctgcctgaca aatgatgggc aaaagacact ggcctcgcta caaaagactg
     1261 tcgaagaaag cttggaagca ggtttggatt tcttgattta agatgatttt agaaaaagtt
     1321 gcgtgcgcaa tcatttttct tgacattctc ttttataagg agtaaaataa agttagcatt
     1381 aaacaaagga gttttaaata tgattgaaat tacctatata gatgccagca agaacgaaag
     1441 aactgtgact ttcgagtctt atgaagactt tgaacgttcg caacaagctt gccttatcgg
     1501 cgtcgcagac tactaccctg tccaaaaatt aacttacaag ggtcataatt tggactacca
     1561 tgggacttat ggagatatct tcttctatct catgaaacaa gatttaagcc aatataacta
     1621 aaaaaaggag aaatacaatg gcaaaagcaa ttacagatgc aacattcgaa caagaaacaa
     1681 aagacggttt ggtcttagta gacttctggg caacttggtg tggtccatgt cgtatgcaag
     1741 gtccaatctt ggacaaattg tctgaagaac tttcagaaga tgtcttgaaa atcgttaaaa
     1801 tggacgttga tgaaaatcca aacacagctc gtgcttttgg aatcatgtct attccaactc
     1861 ttctcttcaa aaaagacggc caagttgtca aacaagttgc aggtgttcac acagcagaac
     1921 aaatcaaggc catcattgct gaattgagct aatcaaacga gagaccaagt actttctttg
     1981 gtctcttttt tcttgccctt tgccattttt caaaaaatat gctagactat agtagattga
     2041 aactagaata gtacacctct acttataaaa cattgttaaa aatcgatttg actgtcctga
     2101 tcgatttatc ctgtttttat ttcattttac tatataagta gaatattacg atgtttggga
     2161 tatgccatcg ctaaaaaaaa aactcgattt ggtatttttt agttccctaa tgggagcttt
     2221 ttgcgtgctc tgaacatttc ccattttgga aggagtactg tgaaacgtca atcagccttg
     2281 gtcgtcttta gtggtggtca agattcaaca acctgccttt tctgggccat gcaacactat
     2341 gaaacagtcg aagctgtcac ctttgcctac ggccaacatc atcacctcga aattcaaatt
     2401 gctagagaaa tcgccaagga acagggcatt cgtcaccata tcctcgatat gtctctgctg
     2461 ggacaaatca ctgctcaacc agactttgcg acgattcata tttcctacat tcctgacaag
     2521 ctctgtgtcg agtcaaaatc cctcaaacta tatctattta gctaccgaaa ccacggagat
     2581 ttccacgaaa actgtatcaa caccatcggg aaagacttgg tcaacttgct agaccctcgc
     2641 tatttagaag tctggggaaa attcactccg cgcggtggca tttcaatcga cccctactat
     2701 aactacggta agcaaggaac taagtatgag ggcttggcag aacaacgcct cttccaacac
     2761 gacctttatc cagagaaaat tgacaaccgc taaagtcata ctcaatgaaa atcaaagagc
     2821 agactaggaa gttagccgca ggttactcaa agcagtgttt gaggttgtag ataaaactga
     2881 cgaagtcagc ttaaaacact gttttgaggt tgcagataga actgacgaag tcagcttaaa
     2941 acactgtttt gaggttgcag atagaactga cgaagtcagc t
//
LOCUS       DBERMM010000081         2932 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.083, whole genome shotgun sequence.
ACCESSION   DBERMM010000081 DBERMM010000000
VERSION     DBERMM010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2932)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2932)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2932
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.083"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..2760
                     /locus_tag="ACL8AS_002049"
     rRNA            <1..2760
                     /locus_tag="ACL8AS_002049"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
     gene            2837..>2932
                     /gene="rrf"
                     /locus_tag="ACL8AS_002050"
     rRNA            2837..>2932
                     /gene="rrf"
                     /locus_tag="ACL8AS_002050"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT          835 a          590 c          859 g          648 t
ORIGIN      
        1 tgttacccac atctgttaag gatgtgagga ggaagacgca gtgaactgaa acatctaagt
       61 agctgcagga agagaaagca aaagcgattg ccttagtagc ggcgagcgaa acggcagaag
      121 ggcaaaccga agagtttact cttcggggtt gtaggactgc aatgtggact caaagattat
      181 agaagaatga tttgggaaga tcagccaaag agagtaatag cctcgtattt aaaatagtct
      241 ttgtacctag cagtatcctg agtacggcgg gacacgtgaa atcccgtcgg aatctgggag
      301 gaccatctcc caaccctaaa tactccctag tgaccgatag tgaaccagta ccgtgaggga
      361 aaggtgaaaa gcaccccggg aggggagtga aatagaacct gaaaccgtgt gcctacaaca
      421 agttcgagcc cgttaatggg tgagagcgtg ccttttgtag aatgaaccgg cgagttacgt
      481 tatgatgcga ggttaagttg aagagacgga gccgtaggga aaccgagtct gaatagggcg
      541 ccttagtatc atgacgtaga cccgaaacca tgtgacctac ccatgagcag gttgaaggtg
      601 cggtaagacg cactggagga ccgaaccagg gcacgttgaa aagtgcttgg atgacttgtg
      661 ggtagcggag aaattccaaa cgaacttgga gatagctggt tctctccgaa atagctttag
      721 ggctagcgtc gacattagag attcttggag gtagagcact gtttgggtga ggggtccatc
      781 ccggattacc aatctcagat aaactccgaa tgccaatgaa ttatggtcgg cagtcagact
      841 gcgagtgcta agatccgtag tcgaaaggga aacagcccag accaccagct aaggtcccaa
      901 aataattgtt aagtggaaaa ggatgtgggg ttgcacagac aactaggatg ttagcttaga
      961 agcagctatt cattcaaaga gtgcgtaata gctcactagt cgagtgaccc tgcgccgaaa
     1021 atgtaccggg gctaaaacaa tttaccgaag ctgtggatac ctttataggt atggtaggag
     1081 agcgttctat gtgtgatgaa ggtataccgt gaggagtgct ggaacgcata gaagtgagaa
     1141 tgccggtatg agtagcgaaa gacaggtgag aatcctgtcc accgtaagac taaggtttcc
     1201 aggggaaggc tcgtccgccc tgggttagtc gggacctaag gagagaccga aaggtgtatc
     1261 cgatggacaa caggttgata ttcctgtact agagtatgta gtgatggagg gacgcagtag
     1321 gctaactaaa gcagacgatt ggaagagtct gtctaagcag tgaggtgtga tatgagtcaa
     1381 atgcttatat ctgtaacatt gagctgtgat ggggagcgaa gtttagtagc gaagttagtg
     1441 acgtcacact gccaagaaaa gcttctagcg tttaaacata ctctacccgt accgcaaacc
     1501 gacacaggta gtcgaggcga gtagcctcag gtgagcgaga gaactctcgt taaggaactc
     1561 ggcaaaatga ccccgtaact tcgggagaag gggtgctgac tttaagtcag ccgcagtgaa
     1621 taggcccaag caactgttta tcaaaaacac agctctctgc taaatcgtaa gatgatgtat
     1681 agggggtgac gcctgcccgg tgctggaagg ttaagaggag tgcttagcgt aagcgaaggt
     1741 atgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg tagcgaaatt
     1801 ccttgtcggg taagttccga cccgcacgaa aggcgtaatg atttgggcac tgtctcaacg
     1861 agagactcgg tgaaatttta gtacctgtga agatgcaggt tacccgcgac aggacggaaa
     1921 gaccccatgg agctttactg cagtttgata ttgagtgtct gtaccacatg tacaggatag
     1981 gtaggagtct aagagatcgg gacgccagtt tcgaaggaga cgctgttggg atactaccct
     2041 tgtgttatgg ccactctaac ccagataggt gatccctatc ggagacagtg tctgacgggc
     2101 agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg ttccctcaga
     2161 atggttggaa atcattcgca gagtgtaaag gtataaggga gcttgactgc gagagctaca
     2221 actcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgtatgg aagggccatc
     2281 gctcaacgga taaaagctac cctggggata acaggcttat ctcccccaag agttcacatc
     2341 gacggggagg tttggcacct cgatgtcggc tcgtcgcatc ctggggctgt agtcggtccc
     2401 aagggttggg ctgttcgccc attaaagcgg cacgcgagct gggttcagaa cgtcgtgaga
     2461 cagttcggtc cctatccgtc gcgggcgtag gaaatttgag aggatctgct cctagtacga
     2521 gaggaccaga gtggacttac cgctggtgta ccagttgtct tgccaaaggc atcgctgggt
     2581 agctatgtag ggaagggata aacgctgaaa gcatctaagt gtgaaaccca cctcaagatg
     2641 agatttccca tgattatata tcagtaagag ccctgagaga tgatcaggta gataggttag
     2701 aagtggaagt gtggcgacac atgtagcgga ctaatactaa tagctcgagg acttatccaa
     2761 agtaactgag aatatgaaag cgaacggttt tcttaaattg aatagatatt caattttgag
     2821 taggtattac tcagagttaa gtgacgatag cctaggagat acacctgtac ccatgccgaa
     2881 cacagaagtt aagccctaga acgccggaag tagttggggg ttgccccctg tg
//
LOCUS       DBERMM010000082         2684 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.084, whole genome shotgun sequence.
ACCESSION   DBERMM010000082 DBERMM010000000
VERSION     DBERMM010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2684)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.084"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..528
                     /locus_tag="ACL8AS_002051"
     CDS             <1..528
                     /locus_tag="ACL8AS_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HGS1229843.1"
                     /translation="KNDLEYNLFNKFVFQSNLWIDLDNGKISLEFLENQLIDEMGHQY
                     QDQIHELVWNWFNYVDLYDEVYELIKQLKKKNFQIYVLSNTSSIFHILLDSVLSKVSS
                     VLDGYVISCEVKMMKPQKEIYLSLVNKYQLDIKDCIFLDDLEENVEAARTLGIKAFQI
                     KERKEISNILKDLLN"
     gene            538..2565
                     /locus_tag="ACL8AS_002052"
     CDS             538..2565
                     /locus_tag="ACL8AS_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000256298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HGS1229844.1"
                     /translation="MVTIKDIARVSGVSHGTVSNVLNKKGNVSAAKIKLVEETAKKLG
                     YNMNSQAQFLRKGASSKCFFLLFNNARKKYAEYFAEIDQLSLDVEYVYLHKFSEIKNK
                     ISAILSENPQFIVCLGFSPKRFVDIEDNIPIFEVDTYQSNKTLSSFDSDKIFEIVLEL
                     VRTEKLSNLYFISLTNEKEHSLFEYLTQKIKNSTHIQVQERLQLLSLYPTLKNFAKYD
                     CIFVDDEDLMHTLLDLFDWFTIIDRPKICLIGSRVWFEKRNLFYIHLDYRILALNTAE
                     NLESGNSSIVPVKDGKQILTNQLFDGECDDIYLLTVHSPMNKALEILSEKYKQISGKN
                     IKIIEKRYDELLEMIESGDVSSSFDMIRMDMAWLPTFGKKYFQEITSFRQTKSINQNI
                     SKSVSREYMYIDQKQYTFPLDVSSQILVYRKDLFEDSFLQRRYFEKTKRKLTVPKSYQ
                     EFDELSEFFTLTENPFSPTLYGHSLALSSSVRAACEFIPRFRERLAQSRMNLAVLPQV
                     LTEYEKSYQFTEKSFNSSWNDFVTNLNSGKTSMEIIFSNYTSPLFDGLNVSAQFEFAT
                     ATIPGNTPVIGGGSIGISKYSNRVEECLNFINWLYSEEISILLTSLGGFLPSKYVMQN
                     RMLQFQYPWLSSLEDTFSIGSRTKWYGFNTDFRFEQMLGQELIESVKHRYG"
BASE COUNT          969 a          309 c          438 g          968 t
ORIGIN      
        1 aagaatgatt tagaatataa tttatttaat aagtttgtat ttcaatctaa cttgtggatt
       61 gatttggata atggtaaaat tagtttagag ttcttagaga atcaattaat cgatgaaatg
      121 ggacatcaat atcaggatca aattcatgag ttagtatgga attggtttaa ctatgttgat
      181 ttatatgatg aagtttatga attaataaaa cagctaaaga aaaagaattt tcaaatttat
      241 gttttatcaa atacctcctc aatttttcat attttattag attctgttct atctaaagta
      301 tcatctgttt tagatggtta cgtaatttct tgtgaagtta aaatgatgaa accacaaaaa
      361 gaaatttact tgtcattagt taataaatat caattagata taaaagattg tatattttta
      421 gatgatttag aagaaaatgt agaagctgca agaactctag gtattaaagc atttcaaatt
      481 aaagagcgta aagagatctc aaatatacta aaagatctct taaactagag gttaattatg
      541 gttacaataa aagatattgc aagagtgtct ggagtctcac atgggacagt ttcaaacgtt
      601 ttaaataaaa aaggtaatgt ctcagcagct aaaataaagt tagtagaaga gactgcgaaa
      661 aaattgggtt ataatatgaa ttctcaagct cagtttcttc gaaaaggcgc ttctagtaaa
      721 tgttttttct tgttatttaa taatgcacgc aaaaagtatg ctgagtattt tgcagaaatt
      781 gatcagttat ctttagatgt agaatatgtt tacttacata aattctcaga gattaaaaat
      841 aagatatctg caattttaag tgaaaatcct caatttatag tttgcttagg tttttctcca
      901 aaaagattcg ttgatattga agataatatt ccgatttttg aagtagatac atatcaatct
      961 aataaaactt tatcttcctt tgatagtgat aaaatatttg agattgtact tgagttggtt
     1021 cggactgaaa agctatctaa tttatatttt atttcactta ctaatgaaaa agaacattct
     1081 ttatttgaat atttgactca aaaaataaaa aactcaactc atatacaagt gcaagaacgt
     1141 ttacaattgt tgtctctata tcctactcta aaaaactttg caaagtatga ttgtatattt
     1201 gttgatgatg aagatttgat gcacacgcta ttagacttat ttgattggtt tactataatt
     1261 gatagaccaa aaatatgttt gataggttca cgtgtttggt tcgaaaaaag aaatcttttt
     1321 tatatacatt tagattatag aatattggca ctcaatactg ccgaaaattt agaaagtgga
     1381 aatagttcaa ttgtaccagt taaagatggc aaacaaattt taactaatca attatttgat
     1441 ggagaatgtg atgatattta tttacttact gtccattcac caatgaataa agccttagaa
     1501 attttatcag aaaagtataa acaaatttct gggaaaaata ttaaaattat cgagaaaaga
     1561 tatgatgaac ttttggagat gattgagtct ggcgatgttt catccagttt tgatatgatt
     1621 agaatggata tggcttggct tccaacattt gggaaaaagt attttcaaga gattacaagc
     1681 tttagacaaa caaaaagtat taatcaaaat atttctaagt cggtgtctcg agaatatatg
     1741 tatattgatc agaagcagta tacttttcca ttggatgtta gtagtcagat tttagtatat
     1801 agaaaagact tatttgaaga ttcattttta caaagacgat actttgaaaa aacaaaaaga
     1861 aaattaactg taccaaaaag ttatcaagag tttgatgagt taagtgaatt ttttacatta
     1921 acagaaaatc cattttcacc tacactttat ggccatagtt tagctttaag ttcttcagtg
     1981 agagcagcat gtgaatttat tcctcggttt cgtgagagat tagcacaatc tagaatgaat
     2041 cttgctgtac ttcctcaggt tttaactgag tatgagaaaa gttatcagtt taccgaaaaa
     2101 tcatttaatt cttcgtggaa cgatttcgtt acgaacttaa acagtggtaa aacttcaatg
     2161 gaaataattt tttcaaatta tactagtcca ttatttgatg gtctcaatgt ttctgctcag
     2221 tttgagtttg caactgccac tatacctggt aatactcctg tgataggtgg tggctcaatt
     2281 ggaatttcta aatattcaaa tagagtggaa gaatgtctaa actttattaa ttggttatat
     2341 tctgaagaga tttctatttt actaacatct ctgggtggtt ttttaccatc aaagtatgtc
     2401 atgcaaaata ggatgttaca atttcaatac ccatggttat ctagtttaga agatacattt
     2461 agtattggga gtagaacaaa atggtacggc tttaatactg attttagatt tgagcagatg
     2521 ttagggcaag agttaataga aagtgtgaag catagatatg gataaattaa tactaaattt
     2581 ttattactag tttatttatt attgtttaaa attaaagatt caagtaaaca ccaattatat
     2641 ttaaaattat tattttgaca tttttctatt gcaaagttat ttta
//
LOCUS       DBERMM010000083         2602 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.085, whole genome shotgun sequence.
ACCESSION   DBERMM010000083 DBERMM010000000
VERSION     DBERMM010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2602)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2602)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2602
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.085"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..1445)
                     /locus_tag="ACL8AS_002053"
     CDS             complement(<1..1445)
                     /locus_tag="ACL8AS_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000661022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HGS1229845.1"
                     /translation="MKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELL
                     GEKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGASHAFLMIGGTTSSVQTMILA
                     TCKAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDH
                     PDAKAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMDAG
                     ADMAAVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRN
                     LALRGKESFEEVIELSEYARHEINTIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIG
                     LTGIEVYDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGK
                     DLIAGEYIQPELVLSPQEAFYSERKSLTLDESVGQVCGEFVMCYPPGIPILAPGERIT
                     REIVDYIQFAKERGCSLQGTEDPEVNHINVI"
     gene            2180..2602
                     /locus_tag="ACL8AS_002054"
                     /pseudo
     CDS             2180..2602
                     /locus_tag="ACL8AS_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
BASE COUNT          787 a          574 c          496 g          745 t
ORIGIN      
        1 ttaatgacgt tgatgtgatt gacctctgga tcttccgtcc cttggaggga gcaaccacgt
       61 tccttggcaa attggatata gtcgacaatt tctcgtgtga tgcgttcgcc aggagccaag
      121 atagggattc ctggagggta acacatgaca aattccccac agacctgtcc aacagattcg
      181 tccaaggtca aactttttct ctctgaatag aaggcttctt gcggagacag cactaactcg
      241 ggctgaatat attctcctgc tatcaaatct tttccatctc ttgaatagag tctcttaata
      301 tcagccagag caccaaccaa gcgctcgatg tcttggatgc ggtcgccgat ggaaatatag
      361 gccaagatat tgccgatatc accaaactcg atctgaatgt cgtattcgtc tcgcaagagg
      421 tcataaacct cgatacctgt taagcctatt ccctgagtgt aaactgacaa cttggttaca
      481 tcaaaatcac agaccgacac accatctatt aactcttttg agtaagcata gtaaccgcca
      541 atggtattga tttcatgacg agcgtactcg gatagctcaa tgacttcctc aaacgactct
      601 ttaccacgaa gggccaagtt gcgacgtgaa atatccaaac tagccatcaa taagtaagag
      661 gcagatgtag actgggtcag gtttataatc tgacgaacgt actcgggatt catctgctcc
      721 ccgattaaaa gaagcgaact ttgtgtcaaa ctcccaccag acttatgcat ggaaactgct
      781 gccatatcag ctcctgcatc catagcagaa attggaagtt taccagtgaa atgcaaatgc
      841 gctccatggg cttcatctac taaaaccatc atgccagctt catgagccat ttctgtcaac
      901 ccctttaggt ctgaacagat gccgtagtaa gtaggattgt tgattaggat agccttagca
      961 tctggatggt cctttatggc ctgtgctact cggtcatttt caagacctaa agcgatacca
     1021 atcttaggat ctacactcat ctcgatatag atgggaatgg caccacatag aaccaacgca
     1081 ttgatagcag atttatggac atttcgtggc agaataatct tatctcctgc cttgcaggtt
     1141 gccagaatca tagtctgcac cgatgaagtt gttccaccaa tcattagaaa ggcatggcta
     1201 gctccaaaag catctgcagc cagctcctct gcatcacgaa taatcgaaat aggatggcct
     1261 aaattatcca agggtttcat cgaattgaca tcaatgccta cacatttttc tcctaagagt
     1321 tcgacaagtt ctggatttcc ccgtccacgc ttgtgacctg gaacatcaaa gggaacaatc
     1381 cttttcttgc gtaacttcac caaggcctca taaattgggg cttggttttg atctaactct
     1441 ttcaaaacat actcctttca atatttttag gaccttatga aaactaagga actaaaggtt
     1501 gactcatgaa aaaagagcag gttttcacct gctctgcaat cttctgacgt gtttattttg
     1561 gtttctgttg agtatgtctg ttcccgatgt ttcctaactc tctagtagca aatattacgt
     1621 actttattga tcgtttcaca agatgacgtg tgctttcacc acactaaaaa tttatgaatt
     1681 agaacaagtg tcctaacatc aacttataaa agtaggcttt taaccctatc aataatgtgg
     1741 cttttcaacc acgcttcggc attcaaccct gcctgtccgt aggcattttt tactcgggtt
     1801 tatatttgct agaaaacatc atctcatttt ctaagcttta ttactatatc atgtttttaa
     1861 gaacttgtaa agtatttttt gataaaaaat aaaaatatag tagattgaaa ctagaatagt
     1921 acacctctgc ttctaaaaca ttgttagaaa tagattttac tgtcctgatc gatttgttct
     1981 gttcttgttt cattttacta tatgttcgta aatgaaagtt ctataatgaa gttagccacc
     2041 cagccctcct aaaaattaga tggttcaact agccgatagc tcttgtaggc ataagaaaac
     2101 acctctgtgt tatacttgtt gttcaaccac aaacacaaga aaggcgcaga gatgcaagac
     2161 cattatacta caaaaggcga acaaagggaa atcaaataga gaaattgcct ctctgcttgg
     2221 aaaagttcct caaactatcc acactgaaat caagcgtagg acagtccgac aatgtcttgg
     2281 aaaagggcgc ttcaaagagg tttattctgc cgactatgct caacagtctt atgaaaacaa
     2341 tcgcaagcgc tcggtcaaga aatcaagctt gaccaaggaa ctaaaggaaa agattctcca
     2401 ctatcataac caaaaatttt cgcctgaaat gatggttatg gctaaagggg ttaacgtggg
     2461 aatttcaacc atttactatt ggattcatca tggaaaattg gggttaagca agcaggattt
     2521 gccttaccct agaaaaggaa aagcgcttaa gaaacaggct agcaccaact ttaaacctgc
     2581 tggtcaatct atcgaacagc gg
//
LOCUS       DBERMM010000084         2202 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.086, whole genome shotgun sequence.
ACCESSION   DBERMM010000084 DBERMM010000000
VERSION     DBERMM010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2202)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2202)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2202
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.086"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            310..1855
                     /locus_tag="ACL8AS_002055"
     rRNA            310..1855
                     /locus_tag="ACL8AS_002055"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
     gene            1907..1979
                     /locus_tag="ACL8AS_002056"
     tRNA            1907..1979
                     /locus_tag="ACL8AS_002056"
                     /product="tRNA-Ala"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1940..1942,aa:Ala,seq:tgc)
     gene            2104..>2202
                     /locus_tag="ACL8AS_002057"
     rRNA            2104..>2202
                     /locus_tag="ACL8AS_002057"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          614 a          449 c          646 g          493 t
ORIGIN      
        1 ggggttaaga caccgccttt tcacggcggt aacacgggtt cgaatcccgt acggactatg
       61 gtatgttgcg gttggaacac ttgatgaaaa aaagtttaaa aaagcttaaa aatcttcaaa
      121 aaagtgttga caagtgaaag tggctgtgat atactaatat agttgtcgct tgagagaagc
      181 aagtgacaaa gacctttgaa aactgaacaa gacgaaccaa tgtgcagggc gctacaacat
      241 aagttgtagt actgaacaat gaaaaaacaa taaatctgtc agtgacagaa atgagtgaga
      301 actcaaactt ttaatgagag tttgatcctg gctcaggacg aacgctggcg gcgtgcctaa
      361 tacatgcaag tagaacgctg aaggaggagc ttgcttctct ggatgagttg cgaacgggtg
      421 agtaacgcgt aggtaacctg cctggtagcg ggggataact attggaaacg atagctaata
      481 ccgcataaga gtggatgttg catgacattt gcttaaaagg tgcacttgca tcactaccag
      541 atggacctgc gttgtattag ctagttggtg gggtaacggc tcaccaaggc gacgatacat
      601 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg
      661 gaggcagcag tagggaatct tcggcaatgg acggaagtct gaccgagcaa cgccgcgtga
      721 gtgaagaagg ttttcggatc gtaaagctct gttgtaagag aagaacgagt gtgagagtgg
      781 aaagttcaca ctgtgacggt atcttaccag aaagggacgg ctaactacgt gccagcagcc
      841 gcggtaatac gtaggtcccg agcgttgtcc ggatttattg ggcgtaaagc gagcgcaggc
      901 ggttagataa gtctgaagtt aaaggctgtg gcttaaccat agtaggcttt ggaaactgtt
      961 taacttgagt gcaagagggg agagtggaat tccatgtgta gcggtgaaat gcgtagatat
     1021 atggaggaac accggtggcg aaagcggctc tctggcttgt aactgacgct gaggctcgaa
     1081 agcgtgggga gcaaacagga ttagataccc tggtagtcca cgctgtaaac gatgagtgct
     1141 aggtgttaga ccctttccgg ggtttagtgc cgtagctaac gcattaagca ctccgcctgg
     1201 ggagtacgac cgcaaggttg aaactcaaag gaattgacgg gggcccgcac aagcggtgga
     1261 gcatgtggtt taattcgaag caacgcgaag aaccttacca ggtcttgaca tccctctgac
     1321 cgctctagag atagagtttt ccttcgggac agaggtgaca ggtggtgcat ggttgtcgtc
     1381 agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaacccct attgttagtt
     1441 gccatcattt agttgggcac tctagcgaga ctgccggtaa taaaccggag gaaggtgggg
     1501 atgacgtcaa atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggctggt
     1561 acaacgagtc gcaagccggt gacggcaagc taatctctta aagccagtct cagttcggat
     1621 tgtaggctgc aactcgccta catgaagtcg gaatcgctag taatcgcgga tcagcacgcc
     1681 gcggtgaata cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac
     1741 acccgaagtc ggtgaggtaa ccgtaaggag ccagccgcct aaggtgggat agatgattgg
     1801 ggtgaagtcg taacaaggta gccgtatcgg aaggtgcggc tggatcacct cctttctaag
     1861 gataaggaac tgcgcattgg tcttgtttag tcttgagagg tcttgtgggg ccttagctca
     1921 gctgggagag cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccat
     1981 tggtgagaga tcaccaagta atgcacattg aaaattgaat atctatatca aatagtaaca
     2041 agaaaataaa ccgaaaacgc tgtagtatta ataagagttt atgactgaaa ggtcagaaaa
     2101 taaggttaag ttaataaggg cgcacggtgg atgccttggc actaggagcc gacgaaggac
     2161 gtgacaaacg acgatatgcc ttgggtagct gtaagtaagc ga
//
LOCUS       DBERMM010000085         1992 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.087, whole genome shotgun sequence.
ACCESSION   DBERMM010000085 DBERMM010000000
VERSION     DBERMM010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1992)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1992)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.087"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(<1..1862)
                     /locus_tag="ACL8AS_002058"
     CDS             complement(<1..1862)
                     /locus_tag="ACL8AS_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078495769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec-dependent serine-rich glycoprotein
                     adhesin"
                     /protein_id="HGS1229846.1"
                     /translation="MFFRRQKGEYRETDRVTRFKLIKSGKHWLRASTSLFGLFKVMRG
                     GVDTTQVMTETVEDKVSHSITGLDILKGIVAAGTVISGTVATQTKVFTNESAVLEKTV
                     EKTDALATNDTVVLGTISTSNSASSTSLSASESASTSASESASTSASTSASTSASESA
                     STSASTSISASSTVVGSQTAAATEATAKKVEEDRKKPASDYAASVTNVNLQSYAKRRK
                     RSVDSIEQLLASIKAAVFSGNTIVNGAPAINASLNIAKSETKIYTGTGKDSIYNIPIY
                     YKLTVTNDGLKLTFTYTVTYVDPITETLGNLSRMTSGYSIYNSGTSTQTMLTLGSGLG
                     KPSGVTNSITNKNGERVQYYNTSTMTKQGSGYTWANGAQMNGWHAKRGHGLTSSWTVP
                     ITGTDTSFTFTPYAAKTDRIGINYFNGGGKVVESSTTSQSLSQSKSLSVSASQSASAS
                     ASTSASASSSTSASASASTSASASASTSASASASTSASASASTSASASASTSASESAS
                     TSASASASTSASASASTSASASASTSASVSASTSASASASTSASASASTSASASASTS
                     ASASASTSASASSSTSASASASTSASASASTSVSASASTSASASASTSASASAST"
BASE COUNT          517 a          412 c          454 g          609 t
ORIGIN      
        1 gtgcttgctg aagccgaagc actcgttgat gctgaagctg acgcactggt acttgctgag
       61 gctgaaacac tcgttgatgc tgaagctgag gcgctagtac ttgctgaggc tgaggcgctt
      121 gtgcttgatg aagctgaggc actggttgac gctgaggctg aggcgctagt acttgctgaa
      181 gccgaagcac tggttgatgc tgaggctgat gcgctggtac ttgctgaggc tgacgcactg
      241 gttgatgctg agactgaagc acttgtgctt gctgaagctg atgcgcttgt gcttgctgaa
      301 gctgaggcac tggttgacgc tgaagctgaa gcactcgttg atgccgattc agaagctgag
      361 gtacttgctg aagccgacgc actggtactt gctgaggctg atgcacttgt tgatgctgaa
      421 gctgatgcgc ttgtgcttgc tgaagctgag gcactggttg acgctgaagc tgaagcactg
      481 gtgcttgatg aagctgacgc actggtactt gctgaagctg acgcgctttg actagcactt
      541 actgagagtg acttagactg tgaaagtgac tgactggtcg tgctagattc aactaccttt
      601 cctccaccat tgaagtagtt aattccaatt ctatctgttt tagcagcgta aggggtaaat
      661 gtaaaggatg tatccgttcc agtaattggt acagtccaag atgatgttaa tccatgtcct
      721 ctcttagcat gccaaccatt catttgggca ccatttgccc aagtataccc actaccctgc
      781 ttcgtcattg tagatgtatt atagtattga acccgttcac catttttgtt agtaatggag
      841 ttcgttacac ctgaaggttt accaagacca ctgccaaggg ttaacattgt ttgtgttgaa
      901 gtacctgagt tatagataga atatccagaa gtcattcttg aaagatttcc aagagtttct
      961 gtgataggat ccacatacgt aaccgtatag gtaaaggtca gttttaagcc atcatttgtc
     1021 actgtcaatt tataataaat tggaatatta taaattgaat ctttacctgt acccgtgtaa
     1081 atttttgtct cacttttagc aatgtttaga cttgcattaa ttgcaggggc gccatttaca
     1141 atcgtattgc cagaaaaaac agcagctttt atagaagcca gcaattgctc gatggaatcc
     1201 actgaacgct tgcgtcgctt agcataagat tggagattga catttgtaac tgatgctgca
     1261 taatcactag ctggtttctt acgatcttct tcgaccttct tagcagttgc ttctgtagcg
     1321 gcagctgttt gtgatcctac cacagtagat gatgcagaga tacttgtcga agccgatgta
     1381 cttgctgatt ctgatgcact tgtactcgct gaggtcgaag cgctggttga ggctgactca
     1441 gatgcagatg tacttgccga ctctgaagct gacaaactag ttgaactcgc tgaattactt
     1501 gtagatatcg tacctagaac tactgtatca tttgttgcca aagcatccgt tttctctaca
     1561 gttttttcaa gtactgccga ctcatttgta aataccttcg tttgagttgc aacggttcca
     1621 cttatgacag ttcccgcagc aactattccc ttgaggatat caagcccagt aattgaatga
     1681 cttactttat cttctaccgt ttcggtcatg acctgagtag tatcaacacc accacgcatg
     1741 accttaaaca agccaaaaag agaagtcgag gcccgtagcc aatgcttccc tgatttgatt
     1801 aatttgaacc gagttactcg gtctgtttct ctatattcac ccttctgacg tctaaaaaat
     1861 attttgaaat ttcctttcga gtattatttt catgtatgga tataaataaa ttaccatact
     1921 ataattatag aatagggaac ccaaaatagc aagaaacttg aggtattttt gctaaaaaaa
     1981 aaaagcattt ta
//
LOCUS       DBERMM010000086         1944 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.088, whole genome shotgun sequence.
ACCESSION   DBERMM010000086 DBERMM010000000
VERSION     DBERMM010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1944)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.088"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(19..201)
                     /locus_tag="ACL8AS_002059"
     CDS             complement(19..201)
                     /locus_tag="ACL8AS_002059"
                     /inference="COORDINATES: protein motif:HMM:NF016232.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HGS1229847.1"
                     /translation="MDLKFEGVDLEYKKAKNNLPESFWETYSAFANTNGGKIILGIDE
                     KNIDTYQRVNRLPAKL"
     gene            536..>1944
                     /gene="pcpA"
                     /locus_tag="ACL8AS_002060"
     CDS             536..>1944
                     /gene="pcpA"
                     /locus_tag="ACL8AS_002060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000753909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein PcpA"
                     /protein_id="HGS1229848.1"
                     /translation="MKKTTILSLTTAAVILAAYVPNEPILADTPSSEVIKETKVGSII
                     QQNNIKYKVLTVEGNIGTVQVGNGVTPVEFEAGQDGKPFTIPTKITVGDKVFTVTEVA
                     SQAFSYYPDETGRIVYYPSSITIPSSIKKIQKKGFHGSKAKTIIFDKGSQLEKIEDRA
                     FDFSELEEIELPASLEYIGTSAFSFSQKLKKLTFSSSSKLELISHEAFANLSNLEKLT
                     LPKSVKTLGSNLFRLTTSLKHVDVEEGNESFASVDGVLFSKDKTQLIYYPSQKNDESY
                     KTPKETKELASYSFNKNSYLKKLELNEGLEKIGTFAFADAIKLEEISLPNSLETIERL
                     AFYGNLELKELILPDNVKNFGKHVMNGLPKLKSLTIGNNINSLPSFFLSGVLDSLKEI
                     HIKNKSTEFSVKKDTFAIPETVKFYVTSEHIKDVLKSNLSTSNDIIVEKVDNIKQETD
                     VAKPKKNSNQGVVGWVKDKG"
BASE COUNT          711 a          266 c          313 g          654 t
ORIGIN      
        1 gttaatggtt tacttgcttc ataatttcgc agggagtcta ttgactcttt ggtaggtgtc
       61 aatgtttttt tcatctatcc cgagaattat tttcccgcca tttgtatttg caaatgctga
      121 gtaggtttcc cagaaagact ctggaagatt gtttttagct tttttgtact ctaaatcaac
      181 cccttcaaat tttaagtcca tatttttcct ttacatctgt tttttgtggt tctggtattt
      241 gttcaagttg agtgataata tagcgaattg aatttcgaga gtttttactc agttaatttc
      301 ttttttaacc cactttaatt tcttttttaa cacgggttaa aaaagaaatt aaagtgggtt
      361 aatttttctt gacttaaaat ttaaaaatga tatactgtgt ttatggagag atgacaattt
      421 ataaaatgta ctactctatt ctactagata atgattgaat aaaacttttt ataacaacgg
      481 ctagcaaagt tataatttta tatctattag aaaataaata tgtaaggaaa tttaaatgaa
      541 aaaaactaca atattatcat taactacagc tgcggttatt ttagcagcat atgtccctaa
      601 tgaaccaatc ctagcagata ctcctagttc ggaagtaatc aaagagacta aagttggaag
      661 tattattcaa caaaataata tcaaatataa ggttctaact gtagaaggta acataggaac
      721 tgttcaagtg ggtaatggag ttactcctgt agagtttgaa gctggtcaag atggaaaacc
      781 attcacgatt cctacaaaaa tcacagtagg tgataaagta tttaccgtta ctgaagtagc
      841 tagtcaagct tttagttatt atccagatga aacaggtaga attgtctact atcctagctc
      901 tattactatc ccatcaagca taaaaaaaat acaaaaaaaa ggcttccatg gaagtaaagc
      961 taaaactatt atttttgaca aaggcagtca gctggagaaa attgaagata gagcttttga
     1021 tttttctgaa ttagaagaga ttgaattgcc tgcatctcta gaatatattg gaacaagtgc
     1081 attttctttt agtcaaaaat tgaaaaagct aaccttttcc tcaagttcaa aattagaatt
     1141 aatatcacat gaggcttttg ctaatttatc aaatttagag aaactaacat taccaaaatc
     1201 ggttaaaaca ttaggaagta atctatttag actcactact agcttaaaac atgttgatgt
     1261 tgaagaagga aatgaatcgt ttgcctcagt tgatggtgtt ttgttttcaa aagataaaac
     1321 tcaattaatt tattatccaa gtcaaaaaaa tgacgaaagt tataaaacgc ctaaggagac
     1381 aaaagaactt gcatcatatt cgtttaataa aaattcttac ttgaaaaaac tcgaattgaa
     1441 tgaaggttta gaaaaaatcg gtacttttgc atttgcggat gcgattaaac ttgaagaaat
     1501 tagcttacca aatagtttag aaactattga acgtttagcc ttttacggta atttagaatt
     1561 aaaagaactt atattaccag ataatgttaa aaattttggt aaacacgtta tgaacggttt
     1621 accaaaatta aaaagtttaa caattggtaa taatatcaac tcattgccgt ccttcttcct
     1681 aagtggcgtc ttagattcat taaaggaaat tcatattaag aataaaagta cagagttttc
     1741 tgtgaaaaaa gatacatttg caattcctga aactgttaag ttctatgtaa catcagaaca
     1801 tataaaagat gttcttaaat caaatttatc tactagtaat gatatcattg ttgaaaaagt
     1861 agataatata aaacaagaaa ctgatgtagc taaacctaaa aagaattcta atcagggagt
     1921 agttggttgg gttaaagaca aagg
//
LOCUS       DBERMM010000087         1505 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.089, whole genome shotgun sequence.
ACCESSION   DBERMM010000087 DBERMM010000000
VERSION     DBERMM010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1505)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.089"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            127..1473
                     /locus_tag="ACL8AS_002061"
     CDS             127..1473
                     /locus_tag="ACL8AS_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element ISSpn5 family transposase"
                     /protein_id="HGS1229849.1"
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKE
                     RISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQL
                     ASQPTLSRFLSRTDKETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTYGKQEG
                     VAYNAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFR
                     MDSGFATPKLYDLIEKTGQCYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSET
                     LYQAGSWSHKRRVCQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIK
                     EMKEGFFGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLH
                     VVGKCVRTGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMH"
BASE COUNT          434 a          334 c          283 g          454 t
ORIGIN      
        1 ccttgcctta gcttagatcc tggatggttt cttttttcac ccaatgggtg ttttttacta
       61 gacaaaaaag agtttcccct ttatggtata agtgtagaaa aaaacacaaa aagaaaggaa
      121 actcacatga acagtttacc aaatcatcac ttccaaaaca agtcttttta ccaactatct
      181 ttcgatggag gtcatttaac ccagtatggt ggtcttatct tttttcagga acttttttcc
      241 cagttgaaac taaaagagcg gatttctaag tatttagtaa cgaatgacca acgccgctac
      301 tgtcgttatt cggattcaga tatccttgtc cagttcctct ttcaactgtt aacaggctat
      361 ggaacggact atgcttgtaa agaattgtca gctgatgcct actttccaaa attgttggaa
      421 ggagggcagc ttgcttcaca gccaacctta tcccgttttc tttccagaac tgacaaggaa
      481 acagtccata gtttgcgatg cctcaacctt gaattggtcg aattcttttt acagtttcac
      541 cagctaaacc aactcattgt agatatcgat tctacccatt tcacaactta tggcaagcaa
      601 gaaggtgttg cttataacgc ccactatcgt gctcatggct atcatcctct ttatgctttc
      661 gaggggaaga caggttattg tttcaatgcc cagcttcgtc ctggtaatcg ttattgttct
      721 gaagaggcag acagctttat cacacctgtt ttagaacggt ttaatcaact tctctttcga
      781 atggatagtg gctttgcgac cccaaaatta tacgatttaa ttgaaaaaac agggcaatgc
      841 tacctcataa aactcaagaa aaatactgtt ctgagccgtc ttggagacct ttccctccct
      901 tgcccacagg atgaggactt aaccatcttg ccccactccg cctactcaga aactctctat
      961 caagcaggat cttggtcgca caagcgtcgt gtctgccagt tctctgaacg aaaagaagga
     1021 aacttgttct acgatgttat ttctctcgtt acaaatatga cgagtggaac aagccaagac
     1081 cagtttcagc tttatcgtgg acgtggtcaa gccgagaatt tcatcaagga gatgaaggag
     1141 ggattttttg gcgataaaac ggatagttca accttaatca aaaacgaagt tcgtatgatg
     1201 atgagctgta tcgcctacaa tctctatctt tttctcaaac atctagctgg aggtgacttc
     1261 caaactttaa caatcaaacg cttccgccat ctttttcttc acgtggtagg aaaatgtgtt
     1321 cgaacaggac gcaagcagct cctcaaattg tctagtctct atgcctattc cgaattgttt
     1381 tcagcacttt attctaggat tagaaaagtc aacctgaatc ttcctgttcc ttatgaacca
     1441 cctagaagaa aagcatcgtt aatgatgcat taaagaacag tcgagatgaa aaaatcgtgt
     1501 gacgc
//
LOCUS       DBERMM010000088         1499 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.090, whole genome shotgun sequence.
ACCESSION   DBERMM010000088 DBERMM010000000
VERSION     DBERMM010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1499)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.090"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            57..513
                     /locus_tag="ACL8AS_002062"
                     /pseudo
     CDS             57..513
                     /locus_tag="ACL8AS_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677118.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
     gene            678..977
                     /locus_tag="ACL8AS_002063"
     CDS             678..977
                     /locus_tag="ACL8AS_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1827 family protein"
                     /protein_id="HGS1229850.1"
                     /translation="MKLINTTNSHSQLVKSQLESTDATLVEVYSAGNTDVIFTQAPLH
                     YEILISNKHRAIREPEIETIQEFFLKRKIDKTSVDEANIKTLYSEKLIGISIPIK"
     gene            1238..>1499
                     /gene="tnpB"
                     /locus_tag="ACL8AS_002064"
     CDS             1238..>1499
                     /gene="tnpB"
                     /locus_tag="ACL8AS_002064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HGS1229851.1"
                     /translation="MMILLSDLGQVHLVCGKTDMRQGIDSLAYVVKTHFELDPFSGQV
                     FLFCGGRKYRFKALYWDGQGFWLLYKRFENGRLTWPSTEKDVK"
BASE COUNT          510 a          295 c          269 g          425 t
ORIGIN      
        1 tgtactattt ttggttcatt tcactataat aataacgata ctagataatg aggaaaatgc
       61 aatggcaaac ccaactttcg gagaaaaaaa gcgaatacag actatattgc tcgctatggc
      121 gtatatgcag ttatccctaa tcctgaacaa aaacaaattg ttcttgttca agaaccaaat
      181 ggtgcttggt tcctaccatg tggagaaatt gaagcaggtg aaaatcatca ggaagcccta
      241 aagcgtgagt tgattgaaga gcttggtttc acagcagaaa ttggtaccta ttacggacaa
      301 gctgacgaat atttctattc tcgtcatcgt gatacctact actacaatcc tgcctacctc
      361 tatgaagcaa cttctttcaa agaagtacaa aagccactag aaaactttaa tcatattgcc
      421 tggttcccta ttgacgaggc tatccaaaac cttaaacgtg gtagccataa atgggccatt
      481 gaatcttgga aaaaacagca taagattggc taatactctt cgaaaataaa attcaaacca
      541 cgtcagcgtc gccttaccgt actcaagtat agcctgcggc tatcttccta gtttgctctt
      601 tgattttcat tgagtataaa tcaagcgact ttattcaaaa agtgctataa tagaattaga
      661 aaatcggagg aaatattatg aagcttatca atacgacaaa ctcacactcg caactggtaa
      721 aaagtcagct agaaagtacc gatgcaaccc ttgttgaggt ttattctgca gggaatacag
      781 atgttatttt tacccaagct ccgcttcact atgaaatcct catctcaaac aaacaccgtg
      841 ctattcgtga gcctgaaatc gaaaccattc aagaattttt cttgaaacgt aaaattgata
      901 agacctctgt tgatgaagcc aatatcaaga cactctactc agagaaatta attggaattt
      961 caatcccaat caagtaagaa aattgagtaa aaactcgatt tgagagaaag tccaataagt
     1021 ctttccataa caaaacgcat agtaacaaga gtttctacac ccactattat acgtttttat
     1081 cattttgaaa tctgctgcta atcaatgaag aagcaaagat caaactaggc agctagttac
     1141 aagttacgta agcgcgtcat aacaaggtat ctatcctaat tccccaactt ccagtatact
     1201 agataaaaaa taattatcag aggaaaggta ttgtactatg atgattctac taagtgattt
     1261 aggtcaagtt caccttgttt gtggcaagac agatatgagg cagggaatag actcattagc
     1321 ctatgtagtt aaaacccact ttgaattgga tcctttctcc ggtcaagtct ttctcttttg
     1381 tggtggacgt aaataccgct ttaaagccct ctactgggat ggtcaaggat tttggctact
     1441 atataaacgc tttgagaacg gcagactgac ttggcccagt acagaaaagg atgtcaaag
//
LOCUS       DBERMM010000089         1457 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.091, whole genome shotgun sequence.
ACCESSION   DBERMM010000089 DBERMM010000000
VERSION     DBERMM010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1457)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.091"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..559
                     /locus_tag="ACL8AS_002065"
     CDS             <1..559
                     /locus_tag="ACL8AS_002065"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1229852.1"
                     /translation="EVPCEIPESWEWVRLNDITSYIQRGKSPKYSNIPIYPVIAQKCN
                     QWSGFSIDLARFIDPETVHSYQKERLLRDGDLMWNSTGLGTLGRLAIYHENKNPYAWA
                     VADSHVTVIRVLSGVINCHFIYNFLSSPIVQSVIEEKASGSTKQKELLTKTIKEYLIP
                     LPPLPEQSRIVDKIEQFFAHIDALI"
     gene            616..1413
                     /gene="psrA"
                     /locus_tag="ACL8AS_002066"
     CDS             616..1413
                     /gene="psrA"
                     /locus_tag="ACL8AS_002066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type DNA invertase PsrA"
                     /protein_id="HGS1229853.1"
                     /translation="MKDFELHLKKAGLAENTVRSYLYGVRFFLENYELKMEDLFEYKG
                     YLLDNFKPKTVNLRLQGVNKYLTFIGHDDLKLKFVKVQQKPFLEDVISHADYLFLKRS
                     LKKDGILKWHFVVWFLGATGARVSELIKLKVEHVEIGYFDIYSKGGKIRRLYIPKKLR
                     NSCLSWLESENRRSGYLFLNKFNEPITARGVAQQLKNYADKYKMNPKVIYPHSFRHLF
                     AKNFLAKYNDIALLADLMGHESIETTRIYLRKTATEQQNIVDKIVNW"
BASE COUNT          505 a          208 c          265 g          479 t
ORIGIN      
        1 ggaagtacct tgtgaaatac cagaaagttg ggaatgggtg aggttaaacg atataacctc
       61 ctacattcaa agagggaagt ctccaaaata ttcaaatatt cctatatacc ctgtgattgc
      121 tcagaaatgt aatcaatggt ctggcttttc tattgactta gcaagattta ttgatcccga
      181 aacagttcat agttaccaga aagaaagatt actaagggat ggtgatttaa tgtggaattc
      241 aacaggtcta ggtacgttag gacgattagc tatttaccat gaaaataaaa atccttatgc
      301 ctgggctgtt gcagatagcc atgttacagt tataagagtc ttatcggggg ttattaattg
      361 ccatttcatc tataattttc tttcctctcc tattgttcag tcagttattg aagaaaaagc
      421 gtcgggtagt acaaaacaaa aagaattatt aacgaaaact ataaaagaat atttaatccc
      481 cctcccaccc cttcctgaac aatccagaat cgttgataaa atcgaacaat ttttcgccca
      541 tattgacgca ctaatttagt ataatagttt tacgtgcggt ggaatttcta tcaaacataa
      601 gataggagtt ttacgttgaa agattttgaa ttacatttga agaaagctgg tttagctgaa
      661 aatactgtgc gttcgtacct ttatggtgtt cgatttttct tggagaatta cgaactcaaa
      721 atggaagatt tatttgaata caaaggatat ttattagaca attttaaacc taaaactgtc
      781 aatttgcgac tacaaggagt aaataaatat ctgactttta ttggtcatga tgatttgaaa
      841 ttaaaatttg tcaaagtaca gcaaaaaccg tttttagaag atgtcattag ccatgctgat
      901 tacctttttc ttaaacgtag tttgaaaaaa gatggtattt taaaatggca ttttgtcgtt
      961 tggtttttag gtgcaactgg ggctcgtgta agtgaactta ttaaactaaa agtagagcat
     1021 gtagaaatcg gttattttga catttactca aaaggtggta aaattcgtag actgtacatt
     1081 cctaaaaaat taagaaatag ttgtcttagt tggttagaat cagaaaatcg tcgaagtggt
     1141 tatttatttt tgaataaatt taacgaacca attacagcaa gaggagttgc tcaacagtta
     1201 aaaaattatg ctgataaata caaaatgaat cctaaagtaa tttaccctca ttcttttagg
     1261 catttatttg ctaagaattt tttagcgaag tataatgata ttgccttgct tgcagatttg
     1321 atgggacacg aaagtataga aactactcga atttatctaa ggaaaacagc tactgaacaa
     1381 caaaatattg tagataaaat tgttaattgg taaaaaataa caggtggtca aactgactac
     1441 ctgctatttt tgtgatt
//
LOCUS       DBERMM010000090         1350 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.092, whole genome shotgun sequence.
ACCESSION   DBERMM010000090 DBERMM010000000
VERSION     DBERMM010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1350)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.092"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            1..888
                     /locus_tag="ACL8AS_002067"
                     /pseudo
     CDS             1..888
                     /locus_tag="ACL8AS_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(1099..>1350)
                     /locus_tag="ACL8AS_002068"
     CDS             complement(1099..>1350)
                     /locus_tag="ACL8AS_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HGS1229854.1"
                     /translation="VPAQPGTEDKKPSAPKPDMQPSPQPEGKKPSVPEINQEKEKAKL
                     AVATEKKLPSTGVASNLVLEIIGLLGLIGTSFIAMKRRK"
BASE COUNT          406 a          275 c          233 g          436 t
ORIGIN      
        1 aacttcaact gtcattcgaa agctcaatga cttccacttt gagtgtaatt ttagaaatct
       61 gcctaagatt atgtcttggg acgttgaaac agtccgggga gtgactgttt caatcgggag
      121 atggagatga gcttcattgc gcaagatttt aacaatctca atatcatcac tgttcttgag
      181 ggaagaacac aagctatcat tcgaaatcac tttcttaaat atgatagagc cgtccgatgt
      241 cgcgtcaaaa ttattactat ggatatgttt agtccttact atgacttagc tagacaactt
      301 ttcccatgtg ctaaaatcgt gttggatcgc tttcacattg tacaacatct tagccgtgct
      361 atgagtcgtg tgcgtgttca aatcatgaat caattggatc gaaagtctca tgaatacaag
      421 gctatcaagc gctactggaa gctcatacaa caggatagtc gtaaactcag cgataaacat
      481 ttttatcgcc ctacttttcg tatgcattta accaataaag agattttaaa caagcttttg
      541 agctattcac aagacttgaa acatcactat cagctctatc aactcttgct gtttcacttt
      601 cagaataagg aaccggagaa atttttcgga ctcattgagg acaatctaaa gcaggttcat
      661 cctctttttc agactgtctt taaaaccttt ctaaaggaca aagagaaaat cgtcaacgcc
      721 cttcaactac actattctaa cgccaaattg gaagcgacca ataatctcat caaacttatc
      781 aagcgcaatg cctttggttt tcggaacttt gaaaacttca aaaaacggat ttttatcgct
      841 ctgaatatca aaaaagaaag gacaaaattt gtcctttctc gagcttagct gacttcaacc
      901 cactacagtt gacaaagagc cttaattgtc taacttttgc ggttcactag ccttctcttt
      961 ttatatctta gattcatctc tatatgaaat gacttataat tattagatac caattataag
     1021 taaaatcttt gggatcttca atggttaacc aatcaaatgc taaatatcga aagtggatat
     1081 ttttaaaaaa ctgaatcatt attttcttct tttcatcgcg atgaatgaag ttccaatcaa
     1141 accaaggaga ccaatgatct caagaactag attagacgcc actcctgtag atggcaattt
     1201 cttctctgtt gctacagcaa gcttagcttt ttctttctcc tgattaatct ctggtacact
     1261 tggtttctta ccctctggtt gagggcttgg ttgcatatct ggttttggag cagatggctt
     1321 tttatcctca gtaccgggtt gtgccggtac
//
LOCUS       DBERMM010000091         1345 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.093, whole genome shotgun sequence.
ACCESSION   DBERMM010000091 DBERMM010000000
VERSION     DBERMM010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1345)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1345)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.093"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            2..1345
                     /locus_tag="ACL8AS_002069"
                     /pseudo
     CDS             2..1345
                     /locus_tag="ACL8AS_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT          513 a          221 c          259 g          352 t
ORIGIN      
        1 tatgaaatta acttatgatg ataaagttca gatctatgaa cttagaaaac aaggatatag
       61 cttagagaag ctttcaaata aatttgggat aaataattct aatcttagat atatgattaa
      121 attgattgat cgttacggaa tagagttcgt caaaaaagga aaaaatcgtt actattctcc
      181 tgatttaaaa caagaaatga ttcataaagt ctgacatgaa ggctggacta aagacagagt
      241 ttctcttgaa tacggtctcc caagtcgtac gatacttctt aactggctag cacaatacag
      301 aaaaaaacgg gtatactatt gttgagaaaa caagagggag agtacctaaa atgggacgta
      361 agccaaaaaa gagacctgaa gagaggacag aattagaaca tcttcaagca gaaaatgagt
      421 acctgagagc ggagaatgcc atcctaaaaa agttaagaga actccgattg aaggaggaaa
      481 aagagaaaga agaaagacag aaattgttca agaattaatg actgagtttt cgttagatat
      541 tcttctaaaa gccattaaac tagctcgttc gacctactac tatcacttga aacagctaga
      601 caaaccagat aaggaccaag agcttaaagc tgaaattcaa tccattttta tcgaacacaa
      661 gggaaattat gcttatcgtc ggatttattt agaactaaga aatcgtggtt atctggtaaa
      721 tcataaaaga gttcaaggct tgatgaaagt actcaattta caagctaaaa tgcgacagaa
      781 acgaaaatat tcttctcata aaggagacgt tggtaagaaa gcagagaatc tcattcaagg
      841 ccaatttgaa ggctctaaaa caatggaaca gtgctacaca gatgtgactg aatttaccat
      901 tccagtaagt actcaaaagc tttacttatc accagtttta gatggtttta acagcgaaat
      961 tatcgcctat aatctttcaa cttcacccaa cttagaacaa gtacaaacaa tgttggaaca
     1021 ggcattcaca gagaagcact acgagaatac gattctctat agtgaccaag gctggcaata
     1081 tcaacacgat tcttatcatc agtttcttga gggtaaggga attcaagcat ccatgtcacg
     1141 taagggtaac agcccagaca atggtatgat ggagtccttc tttgggattc tgaaatcgga
     1201 aatgttttac ggttatgaga agtcgtttca gtcgcttaag caattggaac aagccattgt
     1261 agactatatt gattattaca acaataagag aattaaggta aaactaaaag gacttagccc
     1321 tgtgcaatac agaactaaat ccttc
//
LOCUS       DBERMM010000092         1056 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.094, whole genome shotgun sequence.
ACCESSION   DBERMM010000092 DBERMM010000000
VERSION     DBERMM010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1056)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.094"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..559
                     /locus_tag="ACL8AS_002070"
     CDS             <1..559
                     /locus_tag="ACL8AS_002070"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1229855.1"
                     /translation="NKDETTSYPIYEIPEAWRYIKFASLVNFRIGKTPPRSEATFWGT
                     EIPWVSISDMPISGYVTNTRESISKLALKSKKIDISPKGTLLMSFKLSIGKVAILDIP
                     ATHNEAIISIFPYANKENIIRDYLMIFLPLISTLGDSKDAIKGKTLNSTSISELLIPI
                     SNHEEMKRIISKVDLLFQKVSQLFE"
     gene            complement(507..>1056)
                     /locus_tag="ACL8AS_002071"
     CDS             complement(507..>1056)
                     /locus_tag="ACL8AS_002071"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1229856.1"
                     /translation="PMNWVVIKIKDIFSMNTGLSYKKGDLSINNKGVRIIRGGNIKPL
                     EFSLLDNDYYIDTQFISSEQVYLKHNQLITPVSTSLEHIGKFARIDKDYDGVVAGGFI
                     FQLTPFESSEIISKFLLFNLSSPLFYKQLKAITKLSGQALYNIPKTTLSELLIPLAPF
                     EEQELITQKVEKLFEKVNQLWK"
BASE COUNT          379 a          168 c          155 g          354 t
ORIGIN      
        1 gaataaagac gaaacaacct cttatcctat atatgaaatc ccagaagcat ggagatatat
       61 taaatttgct agcctagtta acttcagaat aggaaaaact cctccacgca gtgaagctac
      121 tttttgggga actgaaatac cttgggtatc tatatcagat atgcctatat ctggttatgt
      181 aactaatacg agagaatcta tttctaaatt agcattaaaa tcaaagaaaa tagacatttc
      241 acctaaagga actttattaa tgagttttaa attatctatt ggaaaagttg ccatattgga
      301 tattcctgcc actcataatg aagccattat atcgatattc ccctatgcta ataaagaaaa
      361 tattatcaga gattacttaa tgatattttt gccacttatc tctactttag gtgattcaaa
      421 agatgctatc aaagggaaaa cattaaatag taccagtatc tccgaattat taatccctat
      481 ttctaatcat gaagagatga aaagaatcat ttccaaagtt gatttacttt ttcaaaaagt
      541 ttctcaactt tttgagtaat aagttcctgt tcctcaaaag gagctaacgg aattaatagc
      601 tcgctcagtg tagttttagg aatattatat aaagcttgac ctgatagttt agttattgct
      661 ttcaattgtt tataaaataa cggagaggac aagttaaata atagaaattt tgaaataatc
      721 tctgaacttt cgaatggtgt taattggaaa ataaatccac cagccacaac accatcatag
      781 tctttatcga ttcttgcaaa ctttccaata tgttctaaag aggttgatac aggtgttatt
      841 agctgattat gttttaaata aacttgctca gaggagatga attgtgtatc aatgtagtaa
      901 tcgttatcca acagagaaaa ttctaaaggc ttaatattac caccacgtat aattctaaca
      961 cctttattat taatgcttaa atcgcccttc ttgtaagaaa gacctgtatt cattgaaaaa
     1021 atatctttta tttttataac aacccaattc ataggt
//
LOCUS       DBERMM010000093          906 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.095, whole genome shotgun sequence.
ACCESSION   DBERMM010000093 DBERMM010000000
VERSION     DBERMM010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 906)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.095"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(33..106)
                     /locus_tag="ACL8AS_002072"
     tRNA            complement(33..106)
                     /locus_tag="ACL8AS_002072"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(70..72),aa:Ile,seq:cat)
     gene            complement(120..193)
                     /locus_tag="ACL8AS_002073"
     tRNA            complement(120..193)
                     /locus_tag="ACL8AS_002073"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(157..159),aa:Met,seq:cat)
     gene            complement(199..272)
                     /locus_tag="ACL8AS_002074"
     tRNA            complement(199..272)
                     /locus_tag="ACL8AS_002074"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(236..238),aa:Pro,seq:tgg)
     gene            complement(288..361)
                     /locus_tag="ACL8AS_002075"
     tRNA            complement(288..361)
                     /locus_tag="ACL8AS_002075"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(325..327),aa:Arg,seq:acg)
     gene            complement(371..456)
                     /locus_tag="ACL8AS_002076"
     tRNA            complement(371..456)
                     /locus_tag="ACL8AS_002076"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(420..422),aa:Leu,seq:taa)
     gene            complement(464..535)
                     /locus_tag="ACL8AS_002077"
     tRNA            complement(464..535)
                     /locus_tag="ACL8AS_002077"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(501..503),aa:Gly,seq:gcc)
     gene            complement(558..630)
                     /locus_tag="ACL8AS_002078"
     tRNA            complement(558..630)
                     /locus_tag="ACL8AS_002078"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(595..597),aa:Thr,seq:tgt)
     gene            complement(649..730)
                     /locus_tag="ACL8AS_002079"
     tRNA            complement(649..730)
                     /locus_tag="ACL8AS_002079"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(694..696),aa:Leu,seq:tag)
     gene            complement(736..808)
                     /locus_tag="ACL8AS_002080"
     tRNA            complement(736..808)
                     /locus_tag="ACL8AS_002080"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(773..775),aa:Lys,seq:ttt)
     gene            complement(833..905)
                     /locus_tag="ACL8AS_002081"
     tRNA            complement(833..905)
                     /locus_tag="ACL8AS_002081"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(870..872),aa:Asp,seq:gtc)
BASE COUNT          238 a          264 c          205 g          199 t
ORIGIN      
        1 agccggactt gggtaatcct ccaatattca aatggacctt gtaggacttg aacctacgac
       61 cactcggtta tgagccgaga gctctaacca gctgagctaa aggtccgaca agatcattat
      121 agcggcgaag gggatcgaac ccccgacctc ccgggtatga accggacgct ctagccagct
      181 gagctacacc gccatgaatc gggaagacag gattcgaacc tgcgacacct tggtcccaaa
      241 ccaagtactc taccaagctg agctacttcc cgagttaaat agaaaaatgc accctagagg
      301 agtcgaacct ctaaccgcct gattcgtagt caggtactct atccagttga gctaagggtg
      361 ctccatatta tgccgaggac cggaatcgaa ccggtacgat cgttaccaat cgcaggattt
      421 taagtcctgt gcgtctgcca gttccgccac cccggcctct ctaagcgaac gacgggattc
      481 gaacccgcga cccccacctt ggcaaggtgg tgttctacca ctgaactacg ttcgcactgt
      541 tttcttctat ctaaaaatgc cggctacatg acttgaacac gcgaccctct gattacaaat
      601 cagatgctct accaactgag ctaagccggc tcatttgtta tatcttaatg cgggttaagg
      661 gacttgaacc cccacgccgt taagcgccag atcctaaatc tggtgcgtct gccaattccg
      721 ccaaacccgc atatatgacc cgtactgggc tcgaaccagt gacccattga ttaaaagtca
      781 attgctctac caactgagct aacgagtcta aaataacttg cgttacctta aacggtcccg
      841 acgggaatcg aacccgcgat cttcgccgtg acagggcgac gtgataaccg ctacactacg
      901 ggacct
//
LOCUS       DBERMM010000094          902 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.096, whole genome shotgun sequence.
ACCESSION   DBERMM010000094 DBERMM010000000
VERSION     DBERMM010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 902)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 902)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.096"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(1..902)
                     /locus_tag="ACL8AS_002082"
                     /pseudo
     CDS             complement(1..902)
                     /locus_tag="ACL8AS_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
BASE COUNT          283 a          147 c          196 g          276 t
ORIGIN      
        1 gtagttgaag ggcgttgaca atcttttctt tatctttgag gaaggtttta aagacagtct
       61 gaaaaatagg atgagcctgc ttaagattgt cctcaataag tccgaaaaat ttctctggtt
      121 ccttattctg gaagtgaaaa agcaagagct gatagagctg atagtggtgt ttcaagtctt
      181 ccgaatagct caaaagcttg tttaaaatct ctttattggt taagtgcata cgaaaagtag
      241 gacgataaaa tcgcttatca ctcagtttac ggctatcctg ttgaatgagt ttccagtagc
      301 gcttaatagc cttgtattca tgggattttc gatgaaactg attcatgatt tggacacgca
      361 cacgactcat agcacggcta agatgttgta caatgtgaaa gcgttcaaga acgattttag
      421 cattcgggag tgaaacagtc tgggagactg tttcagcctg agcctagaaa tttgaaagcg
      481 aagctgttta gccaagtcat agtaaaggct aaacatatcc atagtaatga ttttgacgcg
      541 acatcggaca gctctatcgt agcgaagaaa gtgatttcgg atgacagctt gtgttctgcc
      601 tttaagaata gtgataatat taagattatc aaaatcttgc gcaatgaagc tcatctttcc
      661 ctttgtaaaa gcatactcat cccaagacat aatctcagga agacaagaaa aatcatgttt
      721 aaagtgaaaa tcattgagct tacgaataac agttgaagtt gagatggaaa gctgatgggc
      781 aatatcagtc atagaaatct tttcaattaa cttttgagca atcttttggt tgatgatacg
      841 agggatttgg tgatttttct ttaccagggg agtctcagca accatcattt ttgaacagtg
      901 at
//
LOCUS       DBERMM010000095          857 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.097, whole genome shotgun sequence.
ACCESSION   DBERMM010000095 DBERMM010000000
VERSION     DBERMM010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 857)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 857)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.097"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..>857
                     /locus_tag="ACL8AS_002083"
     CDS             <1..>857
                     /locus_tag="ACL8AS_002083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1167A family transposase"
                     /protein_id="HGS1229857.1"
                     /translation="IAQKLIEKISMTDIAHQLAISTSTVIRKLNDFHFEHDFSRLPKI
                     MSWDEYAFTKGKMSFIAQDFDNLNIITVLEGRTQAVIRNHFLRYDRAVRCQVKIITMD
                     MFSPYYDLAKQLFPCAKIVLDRFHIIQHLSRAMSRFRVQIMNQFERKSHEYKAIKRYW
                     KLIQQDSRKLSDKRFYRPTFRMHLTNKEILDKILSYSEDLKHHYQIYQLLLFHFQNKD
                     PEKFFGLIEDNLKQVHPLFQTVFKTFLKNKEKIVNALQLHYSNAKLEATNNLIKLIKR
                     NAFGFRNFE"
BASE COUNT          266 a          181 c          139 g          271 t
ORIGIN      
        1 attgctcaaa agttaattga aaaaatttct atgactgata ttgcccatca gctggccatt
       61 tcaacttcaa ctgtcattcg caagctcaat gactttcact ttgagcatga tttttctcgg
      121 cttccaaaga ttatgtcttg ggatgagtat gccttcacta agggaaagat gagtttcatt
      181 gcgcaagatt ttgataatct taatattatc actgttcttg aaggcagaac acaagctgtc
      241 atccgaaatc actttcttcg ctacgataga gccgttcgtt gtcaagtgaa aatcattacg
      301 atggatatgt ttagtcctta ctatgacttg gctaaacagc tttttccgtg tgctaaaatc
      361 gttctagatc gtttccatat tatccaacat ctcagccgtg ccatgagtcg ttttcgtgtt
      421 caaattatga atcagtttga acgaaaatct catgaataca aggctatcaa gcgttactgg
      481 aaactcatcc aacaggatag tcgtaaattg agcgataaac gtttttatcg ccctactttt
      541 cgcatgcact taacaaataa agaaattctt gacaagattt taagctattc agaagacttg
      601 aaacaccact atcagatcta tcaactctta ctttttcact ttcagaacaa agaccctgag
      661 aaatttttcg gactcattga ggacaatctg aagcaggttc atcctctttt tcagactgtc
      721 tttaaaacct ttctaaagaa caaagagaaa atcgtcaacg cccttcaact acactattct
      781 aatgccaaac tggaagcgac caataatctc atcaaactta tcaagcgcaa tgcctttggt
      841 tttcggaact ttgaaaa
//
LOCUS       DBERMM010000096          776 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.098, whole genome shotgun sequence.
ACCESSION   DBERMM010000096 DBERMM010000000
VERSION     DBERMM010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 776)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.098"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..>776
                     /locus_tag="ACL8AS_002084"
     CDS             <1..>776
                     /locus_tag="ACL8AS_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HGS1229858.1"
                     /translation="DGSTQEIDVPYDIPDTWEWVRFSTLVEIVRGGSPRPIKDYLTSE
                     VDGINWIKIGDTEKGEKYINNVKEKIKKSGLNKTRFVKKGTFLLTNSMSFGRPYILNV
                     DGAIHDGWLAISNYENSLNKDYLFYILSSNVVYSQFLSLISGAVVKNLNSDKVASILI
                     PLPPLSEQQRIVEAIESALEKVDEYAESYNRLEQLDKEFPDKLKKSILQYAMQGKLVE
                     QDPNDESVEVLLEKIRAEKQKLFEEGKIKKKDLDISIVSQ"
BASE COUNT          294 a          107 c          138 g          237 t
ORIGIN      
        1 tgatggaagc actcaagaaa ttgatgttcc ttatgatatt cctgatactt gggagtgggt
       61 gaggttttct acattggttg aaattgtcag aggtggctct ccacgaccaa tcaaagatta
      121 tcttacttct gaagtagatg gaataaattg gataaaaata ggtgatactg aaaagggtga
      181 aaagtatata aataatgtta aagaaaaaat caaaaaatca gggcttaaca aaactagatt
      241 tgtaaaaaaa ggtacatttt tgttaactaa ttctatgagt tttggtagac cttatatttt
      301 gaatgttgat ggtgcaatac acgatggatg gttggctatt tcgaactatg aaaactcatt
      361 aaataaagat tacctattct atattctttc atcaaatgta gtttattctc aatttctatc
      421 tctaattagt ggagctgttg tgaaaaactt gaatagtgat aaagttgctt ctattcttat
      481 ccctctcccc ccactatccg aacaacaacg aatagtagaa gcaatcgaat cagctttaga
      541 aaaagtagat gaatatgctg aaagttataa tagactagaa cagctagata aagaatttcc
      601 agataaacta aaaaaatcta ttcttcaata tgctatgcaa ggaaaattag ttgaacaaga
      661 cccaaatgat gaatcagtcg aagttttact tgaaaaaata cgagcagaaa aacaaaaact
      721 ctttgaagaa ggcaagatta aaaagaaaga tttggacatt tctattgttt cccaag
//
LOCUS       DBERMM010000097          748 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.099, whole genome shotgun sequence.
ACCESSION   DBERMM010000097 DBERMM010000000
VERSION     DBERMM010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 748)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 748)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.099"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            163..525
                     /locus_tag="ACL8AS_002085"
     CDS             163..525
                     /locus_tag="ACL8AS_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-export chaperone SecB"
                     /protein_id="HGS1229859.1"
                     /translation="MLEVGLNSLISLFTFTFDILYPIVKVGHTDDYSHGAVKLSISLV
                     DKDAMKKISVTVIGYFEINIDENITDILYVNGTAILYPYLRSIVSIVSAIDSSEAMLL
                     PTINVLELLDKSQPFEEE"
BASE COUNT          244 a          107 c          136 g          261 t
ORIGIN      
        1 tcaaaacagt gttttgagct gacttcgtca gttctatcca caacctcaaa acagtgtttt
       61 gagctgacta cgtcagttcc atctacaacc tcaaaacagt gttttgagca acctgaggct
      121 agtttcctag tttgctcttt ggttttcatt gagtataaca cattgttaga agttggttta
      181 aattccctaa tcagtttgtt cacatttacc ttcgatatat tatatcccat agttaaggtt
      241 ggtcatacag atgattatag ccatggagcc gtaaaactta gtatttcttt agttgacaaa
      301 gatgccatga aaaaaatatc tgtaactgta ataggatatt ttgaaataaa tatagatgaa
      361 aatatcaccg atattctata cgtaaatggt actgctattc tttatcctta tttacgttct
      421 attgtttcaa tagtttcggc aattgatagc agtgaagcaa tgttgctacc taccattaat
      481 gttttagagt tactagataa atctcaacct tttgaagaag aataatttat tagctcacta
      541 aattgagggt aaggaaaagt aaaagcagta agaaaaatgt cttgcattat acagcaacct
      601 tttgggaatg agtagatgga ttgaataaaa tttgattaag agtggatgat ttatctgtag
      661 attattattg gacagttagt cttgaagtag tctaagaatt aggttataat cagtagaagc
      721 cttgctaata atgaggaggt tagtttat
//
LOCUS       DBERMM010000098          657 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.100, whole genome shotgun sequence.
ACCESSION   DBERMM010000098 DBERMM010000000
VERSION     DBERMM010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 657)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 657)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.100"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(176..313)
                     /locus_tag="ACL8AS_002086"
                     /pseudo
     CDS             complement(176..313)
                     /locus_tag="ACL8AS_002086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
BASE COUNT          188 a          157 c          132 g          180 t
ORIGIN      
        1 aaggcgacgt tgacgtggtt tgaagagatt ttcgaagagt attagaaagc tcgatggact
       61 attccagatt cattccacta gatttcgaaa tcgagtaggg gataatctct agcccctctc
      121 acaccaccgt acgtgccgtt cggcatacgg cggttcaact agctgttaac gcatgtcatt
      181 caaggtaata atccaaacac gaaaccagtc cacgtttttc aaggactggt tttgatatag
      241 cacgtttaag taccgacttc tgagatacta attgatagtg gtcgccccag ccagatacct
      301 tatccgctat ataggcctta ttatcacgtt cctgttcgta gagccacgat ttcgctatcc
      361 cttcctctga cgattcttat ttccagcgtc agacttaaaa cggtctatcc ccagaccgtt
      421 ttaatccgct acctcacgat agtcagactt gggaatcgct attgggttca ccggtagtag
      481 gtgcccaccg aggacttaca cctcagatat acgacatgcc cgtcgtacat caaaaaaagg
      541 gctctataat atttgtagtg ggtaaccccc ctatagatat tatggagcct attttgtgta
      601 gaaaaaaagt cccatatgac ctataatgaa aagcgacaaa acaactcatt agaaaga
//
LOCUS       DBERMM010000099          581 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.101, whole genome shotgun sequence.
ACCESSION   DBERMM010000099 DBERMM010000000
VERSION     DBERMM010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 581)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 581)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.101"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(20..499)
                     /locus_tag="ACL8AS_002087"
     CDS             complement(20..499)
                     /locus_tag="ACL8AS_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HGS1229860.1"
                     /translation="MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISR
                     EEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRRYDKEPYEEVGEISHRISEGGLW
                     LDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH"
BASE COUNT          150 a          136 c           76 g          219 t
ORIGIN      
        1 attttttttg catgacttac tagtgggtac ggatagtaaa ctccttaaac acaatgcgta
       61 agtctcttaa tactctttga cgccctcgaa atcgttcatt gcttaagacg cgttctagtt
      121 cttcttgttt ctctttactt tgtttgtttc tataatctct tagtgtttca tgaaagagat
      181 aataatcatc tagccagaga cccccctcac ttatacgatg actgatctca cccacttctt
      241 catagggttc tttatcgtat ctacgcttct gactttcctg cttacggata tagtctaaaa
      301 ttcgatttcg aaacttggtt ttgaaatatt tccttaaacg tggaatatcg tctaccagtc
      361 cttcttctct actaatcaat tcatgtaagc agagcatgcc ttcttggtcc caatccgaca
      421 attcccataa atgaaggtaa tattcatttc tacacttata aacagtccct tggacttctt
      481 catacaattc tttaatcata attttcccct ttctagatac agtctaacag attagaaaac
      541 acatttgttc cattttctcc attctgttcc ctttagctcc t
//
LOCUS       DBERMM010000100          556 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.102, whole genome shotgun sequence.
ACCESSION   DBERMM010000100 DBERMM010000000
VERSION     DBERMM010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 556)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 556)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.102"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            <1..>556
                     /locus_tag="ACL8AS_002088"
     CDS             <1..>556
                     /locus_tag="ACL8AS_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229861.1"
                     /translation="FEKLLSINVNELSTPKGDNKQLDILHFINSEMGSYFQCLISLFI
                     NHSSYRDVIIPIINSVTDTDYREFAQGILLNEYNPNRINVTYNTFLGFAYYHSTITIE
                     AADVFTDVVRNILNKKIEDNQILNKVYLVALERVDPTIESFSLSKNNYSQMINIIFTG
                     DYEFRYSKEWLGALFKFDSSANYLV"
BASE COUNT          213 a           69 c           81 g          193 t
ORIGIN      
        1 ttttgaaaaa ttacttagta tcaatgtgaa tgaactctca acaccaaaag gtgataataa
       61 acaattagat atacttcatt ttataaatag tgaaatggga tcatattttc aatgtttaat
      121 atcattattt ataaatcatt caagttatag agatgtaatt attccaataa taaattcagt
      181 aacagatacc gattataggg agtttgctca aggtatttta ttaaatgaat acaatccaaa
      241 cagaatcaat gtaacttaca acaccttttt aggatttgcg tattatcatt ctacaattac
      301 tatcgaagct gcggatgttt tcacagatgt agtaaggaat attctaaaca aaaaaattga
      361 ggacaatcaa attcttaata aagtttatct agttgcttta gagagggtag atccaactat
      421 tgaatcattt tctttatcaa agaataacta tagtcaaatg ataaacatca tttttacagg
      481 agactatgaa tttagatatt ctaaagaatg gttgggagca ttattcaaat ttgactcaag
      541 tgcaaattat ttggtg
//
LOCUS       DBERMM010000101          500 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.denovo.103, whole genome shotgun sequence.
ACCESSION   DBERMM010000101 DBERMM010000000
VERSION     DBERMM010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 500)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.denovo.103"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            complement(112..459)
                     /locus_tag="ACL8AS_002089"
     CDS             complement(112..459)
                     /locus_tag="ACL8AS_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HGS1229862.1"
                     /translation="MNLNQLDIIVSNVPQVCADLEHILDKKADYADDGFAQFTIGSHC
                     LMLSQNHLVPLENFQSGIIIHIEVEDVDQNYKRLNELGIKVLHGPTVTDWGTESLLVQ
                     GPAGLVLDFYRMK"
BASE COUNT          164 a          109 c           74 g          153 t
ORIGIN      
        1 atatgcaatt tctttatata aaaagaccgg attgctccga tctttcaata gttcatattc
       61 tcaatttcta ttttaaaaat agctaaggtt aacgtcaaat gactacgcga cctatttcat
      121 acgataaaaa tcaagcacta gaccagcagg tccttgaact aataaggact ctgttcccca
      181 atcggttaca gttggtccgt gtaaaacctt tataccaagc tcgttcaacc gtttgtagtt
      241 ctggtctaca tcctcaacct cgatatgaat aatgattcct gactgaaagt tttccaaagg
      301 aaccaaatga ttttgtgaca acataaggca gtgactacca atcgtaaact gagcaaaacc
      361 atcatcagca taatctgcct ttttatccaa aatatgctcc aagtcagcac agacttgggg
      421 aacatttgaa acgataatat ctaattgatt taaattcatt tactctcctc cataaaaaga
      481 ccggattgct ccgatctttt
//
LOCUS       DBERMM010000102        17334 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.guided.040, whole genome shotgun sequence.
ACCESSION   DBERMM010000102 DBERMM010000000
VERSION     DBERMM010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 17334)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17334)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17334
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.guided.040"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            66..236
                     /locus_tag="ACL8AS_002090"
                     /pseudo
     CDS             66..236
                     /locus_tag="ACL8AS_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhrA family quorum-sensing system peptide"
     gene            638..952
                     /locus_tag="ACL8AS_002091"
     CDS             638..952
                     /locus_tag="ACL8AS_002091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HGS1229863.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            968..1354
                     /locus_tag="ACL8AS_002092"
     CDS             968..1354
                     /locus_tag="ACL8AS_002092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HGS1229864.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            1383..2768
                     /locus_tag="ACL8AS_002093"
     CDS             1383..2768
                     /locus_tag="ACL8AS_002093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /protein_id="HGS1229865.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            2771..2923
                     /locus_tag="ACL8AS_002094"
     CDS             2771..2923
                     /locus_tag="ACL8AS_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229866.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            2946..4148
                     /gene="mobT"
                     /locus_tag="ACL8AS_002095"
                     /pseudo
     CDS             2946..4148
                     /gene="mobT"
                     /locus_tag="ACL8AS_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MobT family relaxase"
     gene            4197..4364
                     /locus_tag="ACL8AS_002096"
     CDS             4197..4364
                     /locus_tag="ACL8AS_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MLS leader peptide"
                     /protein_id="HGS1229867.1"
                     /translation="MGDKTVRVRADLHHIIKIETAKNGGNVKEVMEIRLRSKLKSVLI
                     VHYLKILYNRN"
     gene            4413..4496
                     /locus_tag="ACL8AS_002097"
     CDS             4413..4496
                     /locus_tag="ACL8AS_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0031556 - transcriptional attenuation by
                     ribosome [Evidence IEA];
                     GO_process: GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="HGS1229868.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
     gene            4621..5358
                     /gene="erm(B)"
                     /locus_tag="ACL8AS_002098"
     CDS             4621..5358
                     /gene="erm(B)"
                     /locus_tag="ACL8AS_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011100845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /protein_id="HGS1229869.1"
                     /translation="MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLT
                     TKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGNIP
                     YHLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAE
                     CFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHA
                     KVNNLSTITYEQVLSIFNSYLLFNGRK"
     gene            complement(5615..6862)
                     /locus_tag="ACL8AS_002099"
     CDS             complement(5615..6862)
                     /locus_tag="ACL8AS_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HGS1229870.1"
                     /translation="MSHNDSILNILGIKDKNIKIISVEEAEHNNDSVKEYITLITATL
                     SYPINRCRNCGFPTVNKDGFRKTHVRLASLNGRRYELELRKQRYKCKSCHTTFGAITN
                     LTKENQTLSSDLKNQIMLLARKGLSGQLIAEMCHCSPSSVRRTILERMEPHYRVAKLP
                     KHLCFDEFRSIKSVMSFICCDAETHQIVTKLQDRLSPTIVDYFESRYSKAERECVQSV
                     VIDLNAQYQSFIYRLFPNANIIIDRFHLVQLAGRALDNCRISILKQLDKQSQEYKIMK
                     SHWKLFHKKAEDLHPEEVVFLRGVKQYMTRQNAVDLITSKFSKFAEVYQTYQDITKAL
                     NERNSELLESTILDYQKTNTEMDTAIQTLRQNRKYVLNSAKFEYSNGPLEGINRKIKT
                     LKRTCYGFANQKFFFLRIDCIFS"
     gene            7042..7263
                     /locus_tag="ACL8AS_002100"
     CDS             7042..7263
                     /locus_tag="ACL8AS_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229871.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            7380..7877
                     /locus_tag="ACL8AS_002101"
     CDS             7380..7877
                     /locus_tag="ACL8AS_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HGS1229872.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            7966..8358
                     /locus_tag="ACL8AS_002102"
     CDS             7966..8358
                     /locus_tag="ACL8AS_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229873.1"
                     /translation="MKKIRSYTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAV
                     MILGNLPPLSMIEGAFLKYFGIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTY
                     AGKKVTLGRNQPQEAITAVRSEFYGISN"
     gene            8342..10787
                     /locus_tag="ACL8AS_002103"
                     /pseudo
     CDS             8342..10787
                     /locus_tag="ACL8AS_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331151.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            10790..12967
                     /locus_tag="ACL8AS_002104"
     CDS             10790..12967
                     /locus_tag="ACL8AS_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CD3337/EF1877 family mobilome membrane protein"
                     /protein_id="HGS1229874.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYAPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            12964..13965
                     /locus_tag="ACL8AS_002105"
     CDS             12964..13965
                     /locus_tag="ACL8AS_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HGS1229875.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            13962..14897
                     /locus_tag="ACL8AS_002106"
     CDS             13962..14897
                     /locus_tag="ACL8AS_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229876.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYYKVNPHKKVVIALWV
                     LLGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKS
                     IDNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQ
                     LITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSI
                     TTNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVT
                     VSLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            15211..15258
                     /locus_tag="ACL8AS_002107"
                     /pseudo
     CDS             15211..15258
                     /locus_tag="ACL8AS_002107"
                     /inference="COORDINATES: protein motif:HMM:NF011335.0"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            15274..17193
                     /gene="tet(M)"
                     /locus_tag="ACL8AS_002108"
     CDS             15274..17193
                     /gene="tet(M)"
                     /locus_tag="ACL8AS_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HGS1229877.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQNIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELKQEESIRFQNCSLFPVYH
                     GSAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLH
                     LRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLG
                     KVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVA
                     QLPLGSGVQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
BASE COUNT         5658 a         3076 c         3587 g         5013 t
ORIGIN      
        1 ataattgact gaataaacta catatgttag aataaaaaca aggaaaaaga aaggggtttc
       61 attgcatgag aaaaaaacgt ggaattaaaa aattagttac atttgcatga ctaggtgttt
      121 ttatgtttag taatacaatt ccttaccaac agtttattca gaagaataaa caattggaga
      181 ttcgagtgca atcacaaaag gagtccaatg gtcttgatgt tgggaaggct gattagttga
      241 ttaaatgatg aaaatactaa ttaactatat ggtatttctg ttttatctaa tttttaatta
      301 gaaaaatagc ataaaaatct agttatccgc ataaaaactg gacttatcac actttatcaa
      361 ggtcaaaacc actcaattta ctactaattt actacttatg aatgagcttt gatacgacga
      421 tttatccttg aaaagtgaag atataaagat acttccaata aaatttgaat atttaatagg
      481 tagacacttc aaaaaatgag gtgtctattt ttttacccga ttttgaaagg aagtgaactt
      541 atgaaaacaa aaaatcaaga atcaaaaggt cgttccccac tctttaagac catcaaacat
      601 tcattcagcc aataaaaaag aaaggatagg taaaaatatg gaacttaaat ttgtgattcc
      661 caacatggaa aaaacattcg gcaatttaga atttgctggc gaggataaag tcgttcagcg
      721 aagaatcaac ggacggctaa ctgtcttatc aagaagctat aatctctatt ctgatgttca
      781 aagagcagat gatattgtgg tggtgcttcc tgctgaagct ggcgaaaaac atttcggctt
      841 tgaggaacgt gtgaagttag tcaatccacg tattaccgca gagggctaca aaatcggcac
      901 tcgtggtttt acaaattacc ttttacatgc tgacgacatg ataaaagaat aaagaaagag
      961 aggaaaaatg atgagattag caaatggcat tgtattagat aaagacacga cttttggaga
     1021 attgaaattc tctgctctac gtcgtgaagt gagaatccaa aatgaagacg ggtcggtttc
     1081 agatgaaatc aaggaacgta cctatgactt aaaatccaaa ggacaaggac gcatgattca
     1141 agtaagtatt cctgccagcg tgcctttgaa agagtttgat tataacgcac gggtggaact
     1201 tatcaatccc attgcggaca ccgttgctac tgccacctat caaggagcag atgttgactg
     1261 gtatatcaag gcagacgata ttgtgctgac aaaggattct agttcattca aagctcaacc
     1321 acaagcaaag aaagaaccga cacaagacaa atagtcgcta ggtagaaagg agactttttc
     1381 gcatgaaaca gcgtggtaaa aggattcgcc catctggtaa agatttagtc tttcatttta
     1441 cgatagcgtc actcctgcct gttttcctgc tggttgtcgg actgtttcat gtgaagacaa
     1501 tccagcagat caactggcag gattttaacc tatcacaagc agataagatt gacattccct
     1561 atttaattat cagtttcagt gtcgcaattc ttatctgctt gctggtagcg tttgtattca
     1621 aacgggttcg ctatgatacg gttaaacaac tttaccaccg tcaaaaactg gcaaagatga
     1681 tacttgaaaa caagtggtat gaatctgaac aggtcaaaac agagggtttc tttaaagata
     1741 gtgctggtcg tacaaaggaa aagataacct acttccctaa aatgtattat cgacttaaaa
     1801 atggcttgat acagatacgg gtggaaatca cgctgggaaa atatcaagac caactcttac
     1861 acttggaaaa gaaattagag agtggcttgt actgtgagct gacggataaa gagttaaagg
     1921 attcctatgt ggaatatact ttgctctatg acaccatagc cagtcgtatt tctattgatg
     1981 aagtagaagc taaagatggt aaacttcgct taatgaaaaa cgtatggtgg gaatatgata
     2041 agctccctca tatgttgatt gctggtggta caggtggcgg taaaacttac tttatactga
     2101 cactgattga agccttgctt catacagatt caaaactgta tattcttgac ccgaaaaatg
     2161 ctgaccttgc ggacttaggt tctgtgatgg caaatgtcta ctatagaaaa gaagacttgc
     2221 tttcttgcat tgaaacattc tatgaagaaa tgatgaaacg tagtgaggaa atgaagcaga
     2281 tgaagaacta taagactggc aaaaattatg cttacttagg tctcccggca cacttcttaa
     2341 tctttgatga atacgtcgct ttcatggaaa tgctgggaac aaaagaaaac accgcagtta
     2401 tgaataagct gaaacagatt gtcatgttag gtcgtcaagc tggcttcttt ctaatactgg
     2461 cttgtcaacg tccagacgca aaatatttag gcgacggaat ccgtgatcag tttaatttca
     2521 gagtggcttt aggtcgtatg tctgaaatgg gctatggcat gatgtttggc agtgacgtac
     2581 aaaaggattt cttcttaaag cgaatcaaag gtcgtggcta tgttgatgta ggaacaagtg
     2641 tcatatcaga gttttatact ccccttgtac caaaaggata tgatttcttg gaggaaatta
     2701 aaaagttatc caacagcaga cagtccacgc aggcgacgtg cgaagcggaa gtcgcaggtg
     2761 tggactgatc ttgctggctg gtgtggcaat agccacgcca gcacttaacc ccccgtatct
     2821 aacagggggg tacaaatcga caggaaacag tcaaaaaaac attagaaaat cctttggtta
     2881 caagggattt acaaaatttc agcgtatgtc aaatgggctt taaaagttga catacgcctt
     2941 tttgattgga gggattttta ctgaatgaac aaacttggtt acagcattta aaagaaaaac
     3001 gcttggctta tggactatct caaaaccgtt tagctgttgc gactggtatt acaaggcagt
     3061 atctaagcga tattgaaaca ggaaaagtca agccatcaga ggatttacag cagtcccttt
     3121 gggaagctct ggaacgcttc aatcccgacg ctccccttga aatgctgttt gattatgtaa
     3181 ggattcgctt tccgacaaca gacgtacagc aggtggtcga aaacatctta caactgaaac
     3241 tgtcctattt tcttcatgag gactatggtt tctattctta ttcagagcat tatgctttag
     3301 gcgacatatt cgtcctttgc tcccatgaac tggacaaagg agttctggtg gaattgaaag
     3361 gtcgtgggtg cagacaattt gaaagctatc ttctggcaca acaaagaagc tggtatgagt
     3421 tctttatgga cgttttggtg gctggcggtg tgatgaaacg ccttgacctt gccattaacg
     3481 ataagacagg gattttgaat atccctgtac tcactgaaaa gtgccaacag gaagaatgta
     3541 tctccgtctt ccgcagtttt aaaagctatc gcagtggcga actggtacgc aaagaggaaa
     3601 aggaatgtat gggaaacacc ctctatatcg gttcattaca aagtgaagtt tatttctgta
     3661 tctatgaaaa ggactacgag cagtacaaga aaaatgatat tcccattgaa gacgcagaag
     3721 taaaaaaccg ttttgagatt cgattgaaaa atgagcgtgc ctattatgca gtccgtgatt
     3781 tactcgtcta tgacaatcca gagcataccg cctttaaaat tatcaatcgg tatatccgtt
     3841 ttgtagataa agacgattcc aaacctcgtt ctgattggaa actgaatgaa gaatgggctt
     3901 ggtttattgg gaacaatcgt gaacgattaa aactaaccac aaaaccagag ccttactcct
     3961 tccaaaggac gctgaactgg ctatctcatc aagttgcccc gaccttaaag gttgcgatta
     4021 aacttgatga aatcaaccag acgcaggttg taaaagacat tctcgaccat gcgaaactga
     4081 cagaccgaca caagcagatt ttgaagcaac agtcagtaaa agaacaggac gtgataacaa
     4141 caaaaaaagg atatctgtca accataccag ttgacagata tccaaaaaaa gatataatgg
     4201 gagataagac ggttcgtgtt cgtgctgact tgcaccatat cataaaaatc gaaacagcaa
     4261 agaatggcgg aaacgtaaaa gaagttatgg aaataagact tagaagcaaa cttaagagtg
     4321 tgttgatagt gcattatctt aaaattttgt ataataggaa ttgaagttaa attagatgct
     4381 aaaaatttgt aattaagaag gagggattcg tcatgttggt attccaaatg cgtaatgtag
     4441 ataaaacatc tactgttttg aaacagacta aaaacagtga ttacgcagat aaataaatac
     4501 gttagattaa ttcctaccag tgactaatct tatgactttt taaacagata actaaaatta
     4561 caaacaaatc gtttaacttc tgtatttgtt tatagatgta atcacttcag gagagattac
     4621 atgaacaaaa atataaaata ttctcaaaac tttttaacga gtgaaaaagt actcaaccaa
     4681 ataataaaac aattgaattt aaaagaaacc gataccgttt acgaaattgg aacaggtaaa
     4741 gggcatttaa cgacgaaact ggctaaaata agtaaacagg taacgtctat tgaattagac
     4801 agtcatctat tcaacttatc gtcagaaaaa ttaaaactga atactcgtgt cactttaatt
     4861 caccaagata ttctacagtt tcaattccct aacaaacaga ggtataaaat tgttgggaat
     4921 attccttacc atttaagcac acaaattatt aaaaaagtgg tttttgaaag ccgtgcgtct
     4981 gacatctatc tgattgttga agaaggattc tacaagcgta ccttggatat tcaccgaaca
     5041 ctagggttgc tcttgcacac tcaagtctcg attcagcaat tgcttaagct gccagcggaa
     5101 tgctttcatc ctaaaccaaa agtaaacagt gtcttaataa aacttacccg ccataccaca
     5161 gatgttccag ataaatattg gaagctatat acgtactttg tttcaaaatg ggtcaatcga
     5221 gaatatcgtc aactgtttac taaaaatcag tttcatcaag caatgaaaca cgccaaagta
     5281 aacaatttaa gtaccattac ttatgagcaa gtattgtcta tttttaatag ttatctatta
     5341 tttaacggga ggaaataatt ctatgagtcg cttttttaaa tttggaaagt tacacgttac
     5401 taaagggaat ggagataaat tattagatat actactgaca gcttccaaga agctaaagag
     5461 gtccctagcg cctacgggga atttgtatcg ataaggggta caaattccca ctaagcgctc
     5521 gggacccctt gtaggaaaat gtcctaagtg ggatatctgt caactggtat ggttgactaa
     5581 aaatacttcc tacgaaaatg tagggggtat ttttttacga aaaaatacaa tcgattctta
     5641 aaaagaaaaa tttttgattg gcaaaaccat aacaagttcg ttttagggtt ttgattttgc
     5701 gattgatgcc ttctaaagga ccattagagt attcaaattt agcgctattt aagacatatt
     5761 ttctgttttg acgaagggtt tgaatagcag tatccatttc tgtattggtt ttttggtagt
     5821 ctaagatggt tgactctagt aattcactat tgcgctcgtt tagggctttc gtgatatctt
     5881 ggtaagtttg gtatacttca gcgaacttgg aaaatttact agtaatgaga tcaacagcat
     5941 tttggcgagt catatattgt ttaacgccgc gaagaaaaac tacttcttca gggtgaagat
     6001 cttcagcttt tttatggaat agcttccaat gtgacttcat aattttatat tcttggctct
     6061 gtttatcaag ttgctttagg atagagatac gacaattgtc caaagcgcga ccagctaatt
     6121 gtacaaggtg gaagcgatca ataatgatat tggcattagg gaaaaggcga tagataaaac
     6181 tttgatattg agcatttaaa tcaattacaa ctgattgaac gcattcgcgt tcggcttttg
     6241 aataacgact ttcaaaataa tcaacaatgg taggtgatag acgatcctgt aactttgtga
     6301 caatttggtg ggtttcagcg tcacaacaga taaaggacat cacagactta attgaacgaa
     6361 actcgtcaaa acatagatgc ttaggcaact tagccacacg atagtgtggt tccatgcgct
     6421 ctaagattgt tcgacgaaca ctgctaggag agcagtgaca catttcagca ataagctgac
     6481 cagataagcc tttacgagct aaaagcatga tttgattttt gagatcactg gataaggttt
     6541 gattttcttt ggttaaatta gtaatagcac caaaagtagt atggcatgat ttacatttat
     6601 agcgttgttt acgaagctct agttcatatc ttctcccatt taaacttgcc agtcgtacat
     6661 gagttttgcg aaagccatcc ttattaactg tgggaaagcc acagttacga caacgattaa
     6721 tcggataaga aagagtagct gttattagcg ttatatactc tttaacagaa tcgttgttgt
     6781 gttcagcttc ttcaacagaa ataattttaa tatttttatc tttaattcca agaatattta
     6841 ggatagaatc attatgggac atttgtttaa ccttctttca tgatttttgt ggtgaattga
     6901 ttgtataacg aggggacagc aaatgtcctc ttttttgtat aaaaaaatct ggcatggaat
     6961 ctctatccat accagaaagt gtatacccca aaaaaataac tcaaatacaa attcattgaa
     7021 tatagagagg agaacatttt tatgaatttt ggacaaaacc tttataactg gtttctatca
     7081 aacgctcaat cactggtgct tttagcaatc gttgtgattg gcttgtatct tggcttcaag
     7141 cgtgagttta gcaaactgat tggcttttta attattgcga ttattgcggt tggcttagtc
     7201 ttcaacgctg ctggagtaaa agacatttta ctagagctat tcaatcgcat tattggtgct
     7261 taaataaaac cgttcttttg tggaatataa gtggttttct tatgttccgc aaaggaatgg
     7321 tacaccaaac gaagtgcggt agggattttt gaatctctac aaagaaagga cgtgaatata
     7381 tggacgatat gcaagtctat attgcgaatt taggcaaata caatgagggc gaattggtcg
     7441 gtgcgtggtt tacctttccc attgactttg aggaagtcaa agagaaaatc ggcttgaatg
     7501 atgaatatga ggaatacgcc attcatgact acgagttacc ctttacggtt gacgaataca
     7561 cttccattgg cgaactcaat cgactatggg aaatggtatc ggaattaccc gaagaattac
     7621 aatcggagct atctgctctg ctcactcatt tttcaagcat tgaagaacta agcgaacatc
     7681 aagaggatat tatcattcat tccgattgtg atgatatgta tgacgtggca cgctactaca
     7741 ttgaagaaac gggtgcttta ggcgaagtac cagctagtct tcaaaactat attgattatc
     7801 aagcctatgg tcgggattta gacctttcag gaacgtttat ctcaaccaat catgggattt
     7861 ttgaaatcgt ctattaaatc tgtcggtaca ttactactgg cagattttct attttacggg
     7921 gtggctcaat cagctacccc tattttttat gaaaggattg attacatgaa gaaaatacga
     7981 agctatacca gtatctggtc tgtggaaaag gtactgtatt ctatcaatga ttttagactt
     8041 ccgtttccca taacctttac gcaaatgaca tggtttgtcg tgtcactctt tgcagtgatg
     8101 atacttggca acttgccccc tctttccatg atagagggag catttctcaa atactttggg
     8161 attcctgtgg ctttcacatg gtttatgtct acaaaaactt ttgatggtaa aaagccttat
     8221 ggatttttga agtctgtcat tgcttatgca ctgcgaccaa agctgaccta tgcaggaaaa
     8281 aaagtaacgc ttggcagaaa ccagccacaa gaagccatta cagcagttag gagtgaattt
     8341 tatggcatat ccaattaaat acattgaaaa caatctcgtc tggaataaag acggggaatg
     8401 ttatgcttac tatgagcttg ttccttacaa ttactcattt ctaagtccag aacagaaaat
     8461 acaagtgcat gattctttca gacagcttat cgcacaaaat cgtgatggca aaattcatgc
     8521 tttacaaatc agtacagaat ccagcatacg ttctgcacaa gagcgttcca aaaatgaagt
     8581 cactggcaag ctcaaagcgg ttgcctatga caaaatcgac caacagacag acgctttaat
     8641 atccatgatt ggcgaaaatc aagtgaacta ccgtttcttt atcggcttta agttgcttct
     8701 caacgatcag gagttttcta tgaaaagtct taccgttgaa gcaaaaaatg ctttgtctga
     8761 ttttgtctat gatgtgaacc ataagctgat gggcgatttt gttagtatga gtaatgatga
     8821 aatcctgcgt tttcagaaga tggaaaagct cttagaaaat aaaatctctc gtcgtttcaa
     8881 aatccgcagg ttagataagg acgacttcgg ctatctgatt gaacaccttt acggacagac
     8941 aggcactgcc tatgaagagt atgagtacca tctatcaaag aaaaagctgg ataatgaaac
     9001 gctgattaaa tactatgact tgattaagcc tactcgctgt ttggtggaag aaaaacagcg
     9061 atatttgaaa atccagcagg aagatgaaac cgtctatgta gcttacttta ccattaacag
     9121 cattgtcgga gaactggact tcccgtcctc tgaaatcttc tactaccagc aacagcaatt
     9181 tacattcccg attgatacgt caatgaatgt ggaaattgta gcgaatcgta aagccctatc
     9241 tactgtccgc aataaaaaga aagaactgaa agacttggat aaccacgctt ggcaaagtga
     9301 taatgaaacc agctccaatg tggcggaagc tctggaaagt gtgaatgagc tggaaaccaa
     9361 tttagaccaa agcaaggaat ctatgtacaa gctgtcttat gtggtaaggg tatcagcaaa
     9421 tgatcttgac gaactcaaac gtcgttgtaa tgaagtgaaa gatttttatg acgatttaag
     9481 cgtaaaactg gtacgaccat ttggggatat gctcggctta catgaagaat ttttacctgc
     9541 cagcaagcgt tatatgaatg attatattca atacgtgacc tctgatttcc tcgctggttt
     9601 aggttttggt gctactcaaa tgctggggga aaatgagggg atttatgttg gctacagctt
     9661 agatactgga cgcaatgtct atctgaaacc tgctcttgcc agtcaagggg ttaagggttc
     9721 agtaaccaat gcgttagcgt cggcttttgt tggttcgctg ggtggtggta aatcctttgc
     9781 gaataacctt atcgtctatt atgcggtgct ttatggggca caagcagtga ttgtagaccc
     9841 aaaagcagaa cgtggcagat ggaaagaaac cttgccagag atttcccatg aaatcaatat
     9901 cgtcactctg acttctgatg agaaaaacaa aggcttactt gacccttatg tgattatgaa
     9961 aaatcccaaa gattctgaat cactggctat tgatattctc attccttacg gggatttcct
    10021 ctcgtgatgg ggaacgcttc ccaatcctta gaaaagccat tcgtgcagta accaatagtg
    10081 aagtacgagg gttgatgaaa gtgattgagg aattacgggt tgagaatacg ccactaagta
    10141 ccagtatagc cgaccatatc gaaagtttta cagactatga ctttgcacat ttattattca
    10201 gtaatggtta tgtggagcag tctatcagct tagaaaaaca actgaacatt atacaggttg
    10261 cggacttggt acttcccgac aaggaaactt cctttgagga atataccact atggagcttt
    10321 tatccgttgc tatgctgatt gtcattagta cctttgcttt agactttatc catacagacc
    10381 gaagcatttt caagattgta gatttagacg aagcatggag ctttttacag gtagcacaag
    10441 gaaaaacact atctatgaag ctggttcggg ctggtcgtgc tatgaacgct ggggtatatt
    10501 tcgtgaccca aaatacagac gacctcttag atgaaaaact gaaaaataac ctcggcttaa
    10561 aatttgcatt tcgttccact gaccttaacg agattaaaaa gaccttagcc ttttttggtg
    10621 tagacccaga ggacgaaaac aatcagaagc gattgcgtga tttggaaaac gggcaatgcc
    10681 ttatcagtga tttatatggt cgtgtcggtg tgatacagtt ccaccctgta tttgaagaac
    10741 tgctccatgc ctttgatacc agaccacctg tgcgaaaaga ggtgtaaatg tgaaaccatc
    10801 aatagtaaac agaataaaat caaactggac gctgaaacgt ctaggtaaag tggcaatgac
    10861 agtggctttc acacttgtga ttgccatttt tcttttagcc atgctgggaa cggtggttca
    10921 agctgcgggc ttggtagatg atacggtcaa tgtggcaaat gaatacagcc gatacccact
    10981 tgaaaactat caactggatt tttatgtgga taatagctgg ggctggcttc cgtggaactg
    11041 gtcggacggg attggaaaac aggtcatgta tggactatat gccattacca attttatttg
    11101 gacaatcagt ttgtatgttt ccaatgcgac aggttactta gtacaggaag cctattcctt
    11161 agacttcatt tccgctacag cagattccat tggtaagaat atgcagacct tagctggtgt
    11221 gagtgcaaac ggattttcaa cagagggttt ctatgttgga ttcctcttac tcttgatttt
    11281 ggttcttggg gtttatgttg cctatacggg actgataaag agagaaacca caaaggcaat
    11341 tcatgccatt atgaattttg tgctggtgtt tatcctatcg gcttccttta ttgcctacgc
    11401 tcccgactac attaaaaaaa tcaatgactt ttcatcagac atcagtaatg ccagtttatc
    11461 acttggcacg aagattgtca tgccccattc cgatagtcaa ggcaaggaca gcgtggactt
    11521 aatcagagat agcctgtttt ccatacaggt tcagcaaccg tggctactgc ttcaatacaa
    11581 cagttcagac attgaaagta tcggtattga ccgtgtggaa agcctgctct ccaccagccc
    11641 agattccaac aatggcgaag acagagaaaa aattgttgcg gaagaaattg aagacagaag
    11701 caataccaat ctaaccatta caaagaccat taaccgttta ggtacagtct tcttcctatt
    11761 tgtcttcaat attgggattt ccatatttgt attcctatta acaggaatca tgattttctc
    11821 gcaggtactt tttatcatct atgctatgtt tctgcctgtg agctttattt taagcatgat
    11881 tccatcattt gatggtatgt caaaacgagc cataacaaag ctctttaata ccattttgac
    11941 acgagctgga atcacattga ttattacgac agcatttagt atttcaacca tgctctatac
    12001 cttatcggct ggttatccgt tctttttgat tgcttttcta cagattgtga cctttgcagg
    12061 aatctacttc aagctgggcg atttaatgag tatgttttct ctacagagta acgattctca
    12121 aagtgtggga agtcgtgtga tgagaaaacc tcgtatgctt atgcacgctc acatgcaccg
    12181 tctacagcgg aaacttggac gttccatgac tactctaggg gctgggtctg ccattgttac
    12241 aggtaaaaaa ggacagtcgg gttcggggag ttctgcaagg acacaagcag atcactcccg
    12301 accagacgga aaggaaaaat caacacttgg aaaacgtatc ggtcaaacca tcggtacagt
    12361 agctgatacc aaagacagaa tggtagacac tgctagtggt ttgaaagaac aggttaaaga
    12421 tttgccgacc aatgcaagat atgcagtata tcaaggaaaa tccaaagtaa aagagaatgt
    12481 ccgtgattta accagtagta tttctcaaac caaagcggac agagccagtg gacgcaagga
    12541 acagcaggaa caaaggcgaa aaaccattgc gaagcgtcgc tctgaaatgg aacaggtcaa
    12601 acagaaaaaa cagcctgctt cttctgttca tgaaagaccg actacaagac aagaacaata
    12661 tcatgatgaa cagacctcaa aacagtctaa tattcagact tcatataagg aatctcaaca
    12721 agccaaacaa gagcgtccag cagttaagtc cgatttttca agtccaaaag tggaacgcca
    12781 aggcaatacc gttcaagaaa aaaccgttca aaagccagca acttcaacca ctacagcaga
    12841 tagaacttca caacgtccaa tcacaaaaga acgtccgtct actgttcaaa gagtaccact
    12901 acaaaataca agaagtagac caccaatcaa aaccgccacc attaagaaag tcggtaagaa
    12961 accatgaagt tgaaaacttt agtgattggt ggttctggat tattcttgat ggtcttctca
    13021 ctgcttctgt ttgttgccat tttattttca gatgaacagg acagcggaat ttccaatatt
    13081 cattatggag gtgtgaatgt ttccgcagaa gtgctggctc ataagcctat ggtagaaaaa
    13141 tatgccaaag aatatggcgt tgaagaatat gtcaacatac ttcttgcgat tatacaggtg
    13201 gaatcgggcg gtactgcgga agatgttatg cagtcctcgg aatccctcgg tcttccacct
    13261 aattcattga gtacagaaga atccattaag caaggtgtga agtatttcag tgaattatta
    13321 gccagtagcg aaaggctcag tgtagattta gaatcggtta tccagtccta caattatggt
    13381 ggtggtttct tagggtatgt ggctaatcgt ggaaataaat atacctttga actggctcaa
    13441 agtttctcaa aagagtattc aggtggcgaa aaagtgtctt accccaatcc catagccata
    13501 cctatcaatg ggggctggcg atacaactat ggcaatatgt tttatgtgca actggtaacg
    13561 cagtatcttg tcacaacaga gtttgatgat gatacggtac aagccatcat ggacgaagca
    13621 ctgaaatatg agggctggcg atacgtttac ggtggagctt ccccgactac ttcttttgat
    13681 tgtagcggac tgacacaatg gacgtatgga aaagctggaa ttaacttacc acgaaccgca
    13741 caacagcaat atgatgtgac ccagcatatc ccactatcgg aagcacaagc tggcgatttg
    13801 gttttctttc attctaccta taacgctggc tcttatatta ctcatgttgg gatatacctt
    13861 ggcaataacc gtatgtttca tgcaggcgac ccaatcggtt atgccgactt aacaagcccc
    13921 tactggcaac agcatttagt gggagcagga cgaatcaaac aatgagaaag gaagatttaa
    13981 tgatgaaatt tagaaaaaat cagaataaag aaaaacagat accaaaggaa aagaaacctc
    14041 gtgtctacta taaggtcaat cctcataaaa aggttgtgat tgccttgtgg gtacttttag
    14101 ggcttagttt cagctttgcg atattcaagc actttacagc tatagatact catactattc
    14161 acgaaacaac tatcatagaa aaggaatacg ttgatactca tcatgtagaa aattttgtag
    14221 agaactttgc gaaagtctac tattcatggg agcaatccga taagtccatt gataatcgaa
    14281 tggaaagtct aaaaggctat ctgacagatg aacttcaagc tctcaatgtt gatacagtac
    14341 gcaaagatat tcctgtatcg tcttctgtaa gaggatttca gatatggacg gtagagccaa
    14401 ctggcgacaa tgagtttaat gtaacctaca gtgtagacca gctcattaca gagggagaaa
    14461 atacaaagac cgtccactct gcttatatag tgagtgtcta tgtagatggt tctggaaata
    14521 tggtactggt taagaatccg accattacca acatacctaa gaaatcaagt tataaaccaa
    14581 aagccattga aagtgagggg acggttgatt ccattacaac caatgaaatc aatgagtttt
    14641 taacgacgtt cttcaagctc tatcctacag cgacagccag tgaactttcc tactatgtga
    14701 atgacgggat attaaaacca atcggaaaag agtacatctt tcaagaactg gtaaatccta
    14761 ttcacaatcg taaggataat caagtcacgg tatcgctgac agtggagtat atcgaccagc
    14821 agaccaaagc aacgcaggta tctcaatttg atttggtact tgaaaagaac gggagtaatt
    14881 ggaagattat agaataacaa atattggtac attattacag ctattttgta atcacgtact
    14941 ctctttgata aaaaattgga gattccttga caaatatgct cttacgtgct attatttaag
    15001 tatctattta aaaggagtta ataaatatgc ggcaaggtat tcttaaataa actgtcaatt
    15061 tgatagtggg aacaaataat tggatgtcct tttttaggag ggcttagttt tttgtaccca
    15121 gtttaagaat acctttatca tgtgattcta aagtatccgg agaatatctg tatgctttgt
    15181 atgcctatgg ttatgcataa aaatcccagt gataaaagta tttatcactg ggatttttat
    15241 gcccttttgg gtttttgaat ggaggaaaat cacatgaaaa ttattaatat tggagtttta
    15301 gctcatgttg atgcaggaaa aactacctta acagaaagct tattatataa cagtggagcg
    15361 attacagaat taggaagcgt ggacaaaggt acaacgagga cggataatac gcttttagaa
    15421 cgtcagagag gaattacaat tcagacagga ataacctctt ttcagtggga aaatacgaag
    15481 gtgaacatca tagacacgcc aggacatatg gatttcttag cagaagtata tcgttcatta
    15541 tcagttttag atggggcaat tctactgatt tctgcaaaag atggcgtaca agcacaaact
    15601 cgtatattat ttcatgcact taggaaaatg gggattccca caatcttttt tatcaataag
    15661 attgaccaaa atggaattga tttatcaacg gtttatcaga atattaaaga gaaactttct
    15721 gccgaaattg taatcaaaca gaaggtagaa ctgtatccta atatgtgtgt gacgaacttt
    15781 accgaatctg aacaatggga tacggtaata gagggaaacg atgacctttt agagaaatat
    15841 atgtccggta aatcattaga agcattggaa ctcaaacaag aggaaagcat aagatttcag
    15901 aattgttctc tgttccctgt ttatcacgga agtgcaaaaa acaatatagg gattgataac
    15961 cttatagaag tgattacgaa taaattttat tcatcaacac atcgaggtca gtctgaactt
    16021 tgcggaaaag ttttcaaaat tgagtattcg gaaaaaagac agcgtcttgc atatatacgt
    16081 ctttatagtg gcgtactgca tttgcgagat tcggttagaa tatcggaaaa ggaaaaaata
    16141 aaaattacag aaatgtatac ttcaataaat ggtgaattat gtaaaattga taaggcttat
    16201 tccggggaaa ttgttatttt gcagaatgag tttttgaagt taaatagtgt tcttggagat
    16261 acaaagctat tgccacagag agagagaatt gaaaatcccc tccctctgct gcaaacgact
    16321 gttgaaccga gcaaacctca acaaagggaa atgttacttg atgcactttt agaaatctcc
    16381 gacagtgacc cgcttctgcg atattatgtg gattctgcga cacatgaaat catactttct
    16441 ttcttaggga aagtacaaat ggaagtgact tgtgctctgc tgcaagaaaa gtatcatgtg
    16501 gagatagaaa taaaagagcc tacagtcatt tatatggaaa gaccgttaaa aaaagcagag
    16561 tataccattc acatcgaagt tccaccgaat cctttctggg cttccattgg tctatctgta
    16621 gcacagcttc cattagggag cggagtacag tatgagagct cggtttctct tggatactta
    16681 aatcaatcgt ttcaaaatgc agttatggag gggatacgct atggctgtga acaaggattg
    16741 tatggttgga atgtgacgga ctgtaaaatc tgttttaagt atggcttata ctatagccct
    16801 gttagtaccc cagcagattt tcggatgctt gctcctattg tattggaaca agtcttaaaa
    16861 aaagctggaa cagaattgtt agagccatat cttagtttta aaatttatgc gccacaggaa
    16921 tatctttcac gagcatacaa cgatgctcct aaatattgtg cgaacatcgt agacactcaa
    16981 ttgaaaaata atgaggtcat tcttagtgga gaaatccctg ctcggtgtat tcaagaatat
    17041 cgtagtgatt taactttctt tacaaatgga cgtagtgttt gtttaacaga gttaaaaggg
    17101 taccatgtta ctaccggtga acctgtttgc cagccccgtc gtccaaatag tcggatagat
    17161 aaagtacgat atatgttcaa taaaataact tagtgtattt tatgttgtta tataaatatg
    17221 gtttcttgtt aaataagatg aaatattctt taataaagat ttgaattaaa gtgtaaagga
    17281 ggagatagtt attataaata agaggcatat accaattaga attcggaata ctat
//
LOCUS       DBERMM010000103        17334 bp    DNA     linear   BCT 24-JAN-2025
DEFINITION  TPA_asm: Streptococcus pneumoniae strain GPSC904 isolate 464069
            SAMN38107161-rid24764283.guided.041, whole genome shotgun sequence.
ACCESSION   DBERMM010000103 DBERMM010000000
VERSION     DBERMM010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN38107161
            Sequence Read Archive: SRR26673347
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 17334)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17334)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JAN-2025) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 18-JAN-2025
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT002570573.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT002570573.1
            Genome Coverage       :: 94x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 01/18/2025 13:19:49
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2024-07-18.build7555
            Genes (total)                     :: 2,127
            CDSs (total)                      :: 2,085
            Genes (coding)                    :: 1,941
            CDSs (with protein)               :: 1,941
            Genes (RNA)                       :: 42
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 35
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 61 of 144
            Pseudo Genes (incomplete)         :: 72 of 144
            Pseudo Genes (internal stop)      :: 49 of 144
            Pseudo Genes (multiple problems)  :: 32 of 144
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17334
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN38107161-rid24764283.guided.041"
                     /strain="GPSC904; 9"
                     /isolate="464069"
                     /isolation_source="hospital"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
                     /collected_by="UKHSA"
     gene            66..236
                     /locus_tag="ACL8AS_002109"
                     /pseudo
     CDS             66..236
                     /locus_tag="ACL8AS_002109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhrA family quorum-sensing system peptide"
     gene            638..952
                     /locus_tag="ACL8AS_002110"
     CDS             638..952
                     /locus_tag="ACL8AS_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HGS1229878.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            968..1354
                     /locus_tag="ACL8AS_002111"
     CDS             968..1354
                     /locus_tag="ACL8AS_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HGS1229879.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            1383..2768
                     /locus_tag="ACL8AS_002112"
     CDS             1383..2768
                     /locus_tag="ACL8AS_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /protein_id="HGS1229880.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            2771..2923
                     /locus_tag="ACL8AS_002113"
     CDS             2771..2923
                     /locus_tag="ACL8AS_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229881.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            2946..4148
                     /gene="mobT"
                     /locus_tag="ACL8AS_002114"
                     /pseudo
     CDS             2946..4148
                     /gene="mobT"
                     /locus_tag="ACL8AS_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MobT family relaxase"
     gene            4197..4364
                     /locus_tag="ACL8AS_002115"
     CDS             4197..4364
                     /locus_tag="ACL8AS_002115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MLS leader peptide"
                     /protein_id="HGS1229882.1"
                     /translation="MGDKTVRVRADLHHIIKIETAKNGGNVKEVMEIRLRSKLKSVLI
                     VHYLKILYNRN"
     gene            4413..4496
                     /locus_tag="ACL8AS_002116"
     CDS             4413..4496
                     /locus_tag="ACL8AS_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0031556 - transcriptional attenuation by
                     ribosome [Evidence IEA];
                     GO_process: GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="HGS1229883.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
     gene            4621..5358
                     /gene="erm(B)"
                     /locus_tag="ACL8AS_002117"
     CDS             4621..5358
                     /gene="erm(B)"
                     /locus_tag="ACL8AS_002117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011100845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /protein_id="HGS1229884.1"
                     /translation="MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLT
                     TKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGNIP
                     YHLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAE
                     CFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHA
                     KVNNLSTITYEQVLSIFNSYLLFNGRK"
     gene            complement(5615..6862)
                     /locus_tag="ACL8AS_002118"
     CDS             complement(5615..6862)
                     /locus_tag="ACL8AS_002118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HGS1229885.1"
                     /translation="MSHNDSILNILGIKDKNIKIISVEEAEHNNDSVKEYITLITATL
                     SYPINRCRNCGFPTVNKDGFRKTHVRLASLNGRRYELELRKQRYKCKSCHTTFGAITN
                     LTKENQTLSSDLKNQIMLLARKGLSGQLIAEMCHCSPSSVRRTILERMEPHYRVAKLP
                     KHLCFDEFRSIKSVMSFICCDAETHQIVTKLQDRLSPTIVDYFESRYSKAERECVQSV
                     VIDLNAQYQSFIYRLFPNANIIIDRFHLVQLAGRALDNCRISILKQLDKQSQEYKIMK
                     SHWKLFHKKAEDLHPEEVVFLRGVKQYMTRQNAVDLITSKFSKFAEVYQTYQDITKAL
                     NERNSELLESTILDYQKTNTEMDTAIQTLRQNRKYVLNSAKFEYSNGPLEGINRKIKT
                     LKRTCYGFANQKFFFLRIDCIFS"
     gene            7042..7263
                     /locus_tag="ACL8AS_002119"
     CDS             7042..7263
                     /locus_tag="ACL8AS_002119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HGS1229886.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            7380..7877
                     /locus_tag="ACL8AS_002120"
     CDS             7380..7877
                     /locus_tag="ACL8AS_002120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HGS1229887.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            7966..8358
                     /locus_tag="ACL8AS_002121"
     CDS             7966..8358
                     /locus_tag="ACL8AS_002121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229888.1"
                     /translation="MKKIRSYTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAV
                     MILGNLPPLSMIEGAFLKYFGIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTY
                     AGKKVTLGRNQPQEAITAVRSEFYGISN"
     gene            8342..10787
                     /locus_tag="ACL8AS_002122"
                     /pseudo
     CDS             8342..10787
                     /locus_tag="ACL8AS_002122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331151.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            10790..12967
                     /locus_tag="ACL8AS_002123"
     CDS             10790..12967
                     /locus_tag="ACL8AS_002123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CD3337/EF1877 family mobilome membrane protein"
                     /protein_id="HGS1229889.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYAPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            12964..13965
                     /locus_tag="ACL8AS_002124"
     CDS             12964..13965
                     /locus_tag="ACL8AS_002124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HGS1229890.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            13962..14897
                     /locus_tag="ACL8AS_002125"
     CDS             13962..14897
                     /locus_tag="ACL8AS_002125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HGS1229891.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYYKVNPHKKVVIALWV
                     LLGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKS
                     IDNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQ
                     LITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSI
                     TTNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVT
                     VSLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            15211..15258
                     /locus_tag="ACL8AS_002126"
                     /pseudo
     CDS             15211..15258
                     /locus_tag="ACL8AS_002126"
                     /inference="COORDINATES: protein motif:HMM:NF011335.0"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            15274..17193
                     /gene="tet(M)"
                     /locus_tag="ACL8AS_002127"
     CDS             15274..17193
                     /gene="tet(M)"
                     /locus_tag="ACL8AS_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HGS1229892.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQNIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFQNCSLFPVYH
                     GSAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLH
                     LRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLG
                     KVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVA
                     QLPLGSGVQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
BASE COUNT         5657 a         3076 c         3588 g         5013 t
ORIGIN      
        1 ataattgact gaataaacta catatgttag aataaaaaca aggaaaaaga aaggggtttc
       61 attgcatgag aaaaaaacgt ggaattaaaa aattagttac atttgcatga ctaggtgttt
      121 ttatgtttag taatacaatt ccttaccaac agtttattca gaagaataaa caattggaga
      181 ttcgagtgca atcacaaaag gagtccaatg gtcttgatgt tgggaaggct gattagttga
      241 ttaaatgatg aaaatactaa ttaactatat ggtatttctg ttttatctaa tttttaatta
      301 gaaaaatagc ataaaaatct agttatccgc ataaaaactg gacttatcac actttatcaa
      361 ggtcaaaacc actcaattta ctactaattt actacttatg aatgagcttt gatacgacga
      421 tttatccttg aaaagtgaag atataaagat acttccaata aaatttgaat atttaatagg
      481 tagacacttc aaaaaatgag gtgtctattt ttttacccga ttttgaaagg aagtgaactt
      541 atgaaaacaa aaaatcaaga atcaaaaggt cgttccccac tctttaagac catcaaacat
      601 tcattcagcc aataaaaaag aaaggatagg taaaaatatg gaacttaaat ttgtgattcc
      661 caacatggaa aaaacattcg gcaatttaga atttgctggc gaggataaag tcgttcagcg
      721 aagaatcaac ggacggctaa ctgtcttatc aagaagctat aatctctatt ctgatgttca
      781 aagagcagat gatattgtgg tggtgcttcc tgctgaagct ggcgaaaaac atttcggctt
      841 tgaggaacgt gtgaagttag tcaatccacg tattaccgca gagggctaca aaatcggcac
      901 tcgtggtttt acaaattacc ttttacatgc tgacgacatg ataaaagaat aaagaaagag
      961 aggaaaaatg atgagattag caaatggcat tgtattagat aaagacacga cttttggaga
     1021 attgaaattc tctgctctac gtcgtgaagt gagaatccaa aatgaagacg ggtcggtttc
     1081 agatgaaatc aaggaacgta cctatgactt aaaatccaaa ggacaaggac gcatgattca
     1141 agtaagtatt cctgccagcg tgcctttgaa agagtttgat tataacgcac gggtggaact
     1201 tatcaatccc attgcggaca ccgttgctac tgccacctat caaggagcag atgttgactg
     1261 gtatatcaag gcagacgata ttgtgctgac aaaggattct agttcattca aagctcaacc
     1321 acaagcaaag aaagaaccga cacaagacaa atagtcgcta ggtagaaagg agactttttc
     1381 gcatgaaaca gcgtggtaaa aggattcgcc catctggtaa agatttagtc tttcatttta
     1441 cgatagcgtc actcctgcct gttttcctgc tggttgtcgg actgtttcat gtgaagacaa
     1501 tccagcagat caactggcag gattttaacc tatcacaagc agataagatt gacattccct
     1561 atttaattat cagtttcagt gtcgcaattc ttatctgctt gctggtagcg tttgtattca
     1621 aacgggttcg ctatgatacg gttaaacaac tttaccaccg tcaaaaactg gcaaagatga
     1681 tacttgaaaa caagtggtat gaatctgaac aggtcaaaac agagggtttc tttaaagata
     1741 gtgctggtcg tacaaaggaa aagataacct acttccctaa aatgtattat cgacttaaaa
     1801 atggcttgat acagatacgg gtggaaatca cgctgggaaa atatcaagac caactcttac
     1861 acttggaaaa gaaattagag agtggcttgt actgtgagct gacggataaa gagttaaagg
     1921 attcctatgt ggaatatact ttgctctatg acaccatagc cagtcgtatt tctattgatg
     1981 aagtagaagc taaagatggt aaacttcgct taatgaaaaa cgtatggtgg gaatatgata
     2041 agctccctca tatgttgatt gctggtggta caggtggcgg taaaacttac tttatactga
     2101 cactgattga agccttgctt catacagatt caaaactgta tattcttgac ccgaaaaatg
     2161 ctgaccttgc ggacttaggt tctgtgatgg caaatgtcta ctatagaaaa gaagacttgc
     2221 tttcttgcat tgaaacattc tatgaagaaa tgatgaaacg tagtgaggaa atgaagcaga
     2281 tgaagaacta taagactggc aaaaattatg cttacttagg tctcccggca cacttcttaa
     2341 tctttgatga atacgtcgct ttcatggaaa tgctgggaac aaaagaaaac accgcagtta
     2401 tgaataagct gaaacagatt gtcatgttag gtcgtcaagc tggcttcttt ctaatactgg
     2461 cttgtcaacg tccagacgca aaatatttag gcgacggaat ccgtgatcag tttaatttca
     2521 gagtggcttt aggtcgtatg tctgaaatgg gctatggcat gatgtttggc agtgacgtac
     2581 aaaaggattt cttcttaaag cgaatcaaag gtcgtggcta tgttgatgta ggaacaagtg
     2641 tcatatcaga gttttatact ccccttgtac caaaaggata tgatttcttg gaggaaatta
     2701 aaaagttatc caacagcaga cagtccacgc aggcgacgtg cgaagcggaa gtcgcaggtg
     2761 tggactgatc ttgctggctg gtgtggcaat agccacgcca gcacttaacc ccccgtatct
     2821 aacagggggg tacaaatcga caggaaacag tcaaaaaaac attagaaaat cctttggtta
     2881 caagggattt acaaaatttc agcgtatgtc aaatgggctt taaaagttga catacgcctt
     2941 tttgattgga gggattttta ctgaatgaac aaacttggtt acagcattta aaagaaaaac
     3001 gcttggctta tggactatct caaaaccgtt tagctgttgc gactggtatt acaaggcagt
     3061 atctaagcga tattgaaaca ggaaaagtca agccatcaga ggatttacag cagtcccttt
     3121 gggaagctct ggaacgcttc aatcccgacg ctccccttga aatgctgttt gattatgtaa
     3181 ggattcgctt tccgacaaca gacgtacagc aggtggtcga aaacatctta caactgaaac
     3241 tgtcctattt tcttcatgag gactatggtt tctattctta ttcagagcat tatgctttag
     3301 gcgacatatt cgtcctttgc tcccatgaac tggacaaagg agttctggtg gaattgaaag
     3361 gtcgtgggtg cagacaattt gaaagctatc ttctggcaca acaaagaagc tggtatgagt
     3421 tctttatgga cgttttggtg gctggcggtg tgatgaaacg ccttgacctt gccattaacg
     3481 ataagacagg gattttgaat atccctgtac tcactgaaaa gtgccaacag gaagaatgta
     3541 tctccgtctt ccgcagtttt aaaagctatc gcagtggcga actggtacgc aaagaggaaa
     3601 aggaatgtat gggaaacacc ctctatatcg gttcattaca aagtgaagtt tatttctgta
     3661 tctatgaaaa ggactacgag cagtacaaga aaaatgatat tcccattgaa gacgcagaag
     3721 taaaaaaccg ttttgagatt cgattgaaaa atgagcgtgc ctattatgca gtccgtgatt
     3781 tactcgtcta tgacaatcca gagcataccg cctttaaaat tatcaatcgg tatatccgtt
     3841 ttgtagataa agacgattcc aaacctcgtt ctgattggaa actgaatgaa gaatgggctt
     3901 ggtttattgg gaacaatcgt gaacgattaa aactaaccac aaaaccagag ccttactcct
     3961 tccaaaggac gctgaactgg ctatctcatc aagttgcccc gaccttaaag gttgcgatta
     4021 aacttgatga aatcaaccag acgcaggttg taaaagacat tctcgaccat gcgaaactga
     4081 cagaccgaca caagcagatt ttgaagcaac agtcagtaaa agaacaggac gtgataacaa
     4141 caaaaaaagg atatctgtca accataccag ttgacagata tccaaaaaaa gatataatgg
     4201 gagataagac ggttcgtgtt cgtgctgact tgcaccatat cataaaaatc gaaacagcaa
     4261 agaatggcgg aaacgtaaaa gaagttatgg aaataagact tagaagcaaa cttaagagtg
     4321 tgttgatagt gcattatctt aaaattttgt ataataggaa ttgaagttaa attagatgct
     4381 aaaaatttgt aattaagaag gagggattcg tcatgttggt attccaaatg cgtaatgtag
     4441 ataaaacatc tactgttttg aaacagacta aaaacagtga ttacgcagat aaataaatac
     4501 gttagattaa ttcctaccag tgactaatct tatgactttt taaacagata actaaaatta
     4561 caaacaaatc gtttaacttc tgtatttgtt tatagatgta atcacttcag gagagattac
     4621 atgaacaaaa atataaaata ttctcaaaac tttttaacga gtgaaaaagt actcaaccaa
     4681 ataataaaac aattgaattt aaaagaaacc gataccgttt acgaaattgg aacaggtaaa
     4741 gggcatttaa cgacgaaact ggctaaaata agtaaacagg taacgtctat tgaattagac
     4801 agtcatctat tcaacttatc gtcagaaaaa ttaaaactga atactcgtgt cactttaatt
     4861 caccaagata ttctacagtt tcaattccct aacaaacaga ggtataaaat tgttgggaat
     4921 attccttacc atttaagcac acaaattatt aaaaaagtgg tttttgaaag ccgtgcgtct
     4981 gacatctatc tgattgttga agaaggattc tacaagcgta ccttggatat tcaccgaaca
     5041 ctagggttgc tcttgcacac tcaagtctcg attcagcaat tgcttaagct gccagcggaa
     5101 tgctttcatc ctaaaccaaa agtaaacagt gtcttaataa aacttacccg ccataccaca
     5161 gatgttccag ataaatattg gaagctatat acgtactttg tttcaaaatg ggtcaatcga
     5221 gaatatcgtc aactgtttac taaaaatcag tttcatcaag caatgaaaca cgccaaagta
     5281 aacaatttaa gtaccattac ttatgagcaa gtattgtcta tttttaatag ttatctatta
     5341 tttaacggga ggaaataatt ctatgagtcg cttttttaaa tttggaaagt tacacgttac
     5401 taaagggaat ggagataaat tattagatat actactgaca gcttccaaga agctaaagag
     5461 gtccctagcg cctacgggga atttgtatcg ataaggggta caaattccca ctaagcgctc
     5521 gggacccctt gtaggaaaat gtcctaagtg ggatatctgt caactggtat ggttgactaa
     5581 aaatacttcc tacgaaaatg tagggggtat ttttttacga aaaaatacaa tcgattctta
     5641 aaaagaaaaa tttttgattg gcaaaaccat aacaagttcg ttttagggtt ttgattttgc
     5701 gattgatgcc ttctaaagga ccattagagt attcaaattt agcgctattt aagacatatt
     5761 ttctgttttg acgaagggtt tgaatagcag tatccatttc tgtattggtt ttttggtagt
     5821 ctaagatggt tgactctagt aattcactat tgcgctcgtt tagggctttc gtgatatctt
     5881 ggtaagtttg gtatacttca gcgaacttgg aaaatttact agtaatgaga tcaacagcat
     5941 tttggcgagt catatattgt ttaacgccgc gaagaaaaac tacttcttca gggtgaagat
     6001 cttcagcttt tttatggaat agcttccaat gtgacttcat aattttatat tcttggctct
     6061 gtttatcaag ttgctttagg atagagatac gacaattgtc caaagcgcga ccagctaatt
     6121 gtacaaggtg gaagcgatca ataatgatat tggcattagg gaaaaggcga tagataaaac
     6181 tttgatattg agcatttaaa tcaattacaa ctgattgaac gcattcgcgt tcggcttttg
     6241 aataacgact ttcaaaataa tcaacaatgg taggtgatag acgatcctgt aactttgtga
     6301 caatttggtg ggtttcagcg tcacaacaga taaaggacat cacagactta attgaacgaa
     6361 actcgtcaaa acatagatgc ttaggcaact tagccacacg atagtgtggt tccatgcgct
     6421 ctaagattgt tcgacgaaca ctgctaggag agcagtgaca catttcagca ataagctgac
     6481 cagataagcc tttacgagct aaaagcatga tttgattttt gagatcactg gataaggttt
     6541 gattttcttt ggttaaatta gtaatagcac caaaagtagt atggcatgat ttacatttat
     6601 agcgttgttt acgaagctct agttcatatc ttctcccatt taaacttgcc agtcgtacat
     6661 gagttttgcg aaagccatcc ttattaactg tgggaaagcc acagttacga caacgattaa
     6721 tcggataaga aagagtagct gttattagcg ttatatactc tttaacagaa tcgttgttgt
     6781 gttcagcttc ttcaacagaa ataattttaa tatttttatc tttaattcca agaatattta
     6841 ggatagaatc attatgggac atttgtttaa ccttctttca tgatttttgt ggtgaattga
     6901 ttgtataacg aggggacagc aaatgtcctc ttttttgtat aaaaaaatct ggcatggaat
     6961 ctctatccat accagaaagt gtatacccca aaaaaataac tcaaatacaa attcattgaa
     7021 tatagagagg agaacatttt tatgaatttt ggacaaaacc tttataactg gtttctatca
     7081 aacgctcaat cactggtgct tttagcaatc gttgtgattg gcttgtatct tggcttcaag
     7141 cgtgagttta gcaaactgat tggcttttta attattgcga ttattgcggt tggcttagtc
     7201 ttcaacgctg ctggagtaaa agacatttta ctagagctat tcaatcgcat tattggtgct
     7261 taaataaaac cgttcttttg tggaatataa gtggttttct tatgttccgc aaaggaatgg
     7321 tacaccaaac gaagtgcggt agggattttt gaatctctac aaagaaagga cgtgaatata
     7381 tggacgatat gcaagtctat attgcgaatt taggcaaata caatgagggc gaattggtcg
     7441 gtgcgtggtt tacctttccc attgactttg aggaagtcaa agagaaaatc ggcttgaatg
     7501 atgaatatga ggaatacgcc attcatgact acgagttacc ctttacggtt gacgaataca
     7561 cttccattgg cgaactcaat cgactatggg aaatggtatc ggaattaccc gaagaattac
     7621 aatcggagct atctgctctg ctcactcatt tttcaagcat tgaagaacta agcgaacatc
     7681 aagaggatat tatcattcat tccgattgtg atgatatgta tgacgtggca cgctactaca
     7741 ttgaagaaac gggtgcttta ggcgaagtac cagctagtct tcaaaactat attgattatc
     7801 aagcctatgg tcgggattta gacctttcag gaacgtttat ctcaaccaat catgggattt
     7861 ttgaaatcgt ctattaaatc tgtcggtaca ttactactgg cagattttct attttacggg
     7921 gtggctcaat cagctacccc tattttttat gaaaggattg attacatgaa gaaaatacga
     7981 agctatacca gtatctggtc tgtggaaaag gtactgtatt ctatcaatga ttttagactt
     8041 ccgtttccca taacctttac gcaaatgaca tggtttgtcg tgtcactctt tgcagtgatg
     8101 atacttggca acttgccccc tctttccatg atagagggag catttctcaa atactttggg
     8161 attcctgtgg ctttcacatg gtttatgtct acaaaaactt ttgatggtaa aaagccttat
     8221 ggatttttga agtctgtcat tgcttatgca ctgcgaccaa agctgaccta tgcaggaaaa
     8281 aaagtaacgc ttggcagaaa ccagccacaa gaagccatta cagcagttag gagtgaattt
     8341 tatggcatat ccaattaaat acattgaaaa caatctcgtc tggaataaag acggggaatg
     8401 ttatgcttac tatgagcttg ttccttacaa ttactcattt ctaagtccag aacagaaaat
     8461 acaagtgcat gattctttca gacagcttat cgcacaaaat cgtgatggca aaattcatgc
     8521 tttacaaatc agtacagaat ccagcatacg ttctgcacaa gagcgttcca aaaatgaagt
     8581 cactggcaag ctcaaagcgg ttgcctatga caaaatcgac caacagacag acgctttaat
     8641 atccatgatt ggcgaaaatc aagtgaacta ccgtttcttt atcggcttta agttgcttct
     8701 caacgatcag gagttttcta tgaaaagtct taccgttgaa gcaaaaaatg ctttgtctga
     8761 ttttgtctat gatgtgaacc ataagctgat gggcgatttt gttagtatga gtaatgatga
     8821 aatcctgcgt tttcagaaga tggaaaagct cttagaaaat aaaatctctc gtcgtttcaa
     8881 aatccgcagg ttagataagg acgacttcgg ctatctgatt gaacaccttt acggacagac
     8941 aggcactgcc tatgaagagt atgagtacca tctatcaaag aaaaagctgg ataatgaaac
     9001 gctgattaaa tactatgact tgattaagcc tactcgctgt ttggtggaag aaaaacagcg
     9061 atatttgaaa atccagcagg aagatgaaac cgtctatgta gcttacttta ccattaacag
     9121 cattgtcgga gaactggact tcccgtcctc tgaaatcttc tactaccagc aacagcaatt
     9181 tacattcccg attgatacgt caatgaatgt ggaaattgta gcgaatcgta aagccctatc
     9241 tactgtccgc aataaaaaga aagaactgaa agacttggat aaccacgctt ggcaaagtga
     9301 taatgaaacc agctccaatg tggcggaagc tctggaaagt gtgaatgagc tggaaaccaa
     9361 tttagaccaa agcaaggaat ctatgtacaa gctgtcttat gtggtaaggg tatcagcaaa
     9421 tgatcttgac gaactcaaac gtcgttgtaa tgaagtgaaa gatttttatg acgatttaag
     9481 cgtaaaactg gtacgaccat ttggggatat gctcggctta catgaagaat ttttacctgc
     9541 cagcaagcgt tatatgaatg attatattca atacgtgacc tctgatttcc tcgctggttt
     9601 aggttttggt gctactcaaa tgctggggga aaatgagggg atttatgttg gctacagctt
     9661 agatactgga cgcaatgtct atctgaaacc tgctcttgcc agtcaagggg ttaagggttc
     9721 agtaaccaat gcgttagcgt cggcttttgt tggttcgctg ggtggtggta aatcctttgc
     9781 gaataacctt atcgtctatt atgcggtgct ttatggggca caagcagtga ttgtagaccc
     9841 aaaagcagaa cgtggcagat ggaaagaaac cttgccagag atttcccatg aaatcaatat
     9901 cgtcactctg acttctgatg agaaaaacaa aggcttactt gacccttatg tgattatgaa
     9961 aaatcccaaa gattctgaat cactggctat tgatattctc attccttacg gggatttcct
    10021 ctcgtgatgg ggaacgcttc ccaatcctta gaaaagccat tcgtgcagta accaatagtg
    10081 aagtacgagg gttgatgaaa gtgattgagg aattacgggt tgagaatacg ccactaagta
    10141 ccagtatagc cgaccatatc gaaagtttta cagactatga ctttgcacat ttattattca
    10201 gtaatggtta tgtggagcag tctatcagct tagaaaaaca actgaacatt atacaggttg
    10261 cggacttggt acttcccgac aaggaaactt cctttgagga atataccact atggagcttt
    10321 tatccgttgc tatgctgatt gtcattagta cctttgcttt agactttatc catacagacc
    10381 gaagcatttt caagattgta gatttagacg aagcatggag ctttttacag gtagcacaag
    10441 gaaaaacact atctatgaag ctggttcggg ctggtcgtgc tatgaacgct ggggtatatt
    10501 tcgtgaccca aaatacagac gacctcttag atgaaaaact gaaaaataac ctcggcttaa
    10561 aatttgcatt tcgttccact gaccttaacg agattaaaaa gaccttagcc ttttttggtg
    10621 tagacccaga ggacgaaaac aatcagaagc gattgcgtga tttggaaaac gggcaatgcc
    10681 ttatcagtga tttatatggt cgtgtcggtg tgatacagtt ccaccctgta tttgaagaac
    10741 tgctccatgc ctttgatacc agaccacctg tgcgaaaaga ggtgtaaatg tgaaaccatc
    10801 aatagtaaac agaataaaat caaactggac gctgaaacgt ctaggtaaag tggcaatgac
    10861 agtggctttc acacttgtga ttgccatttt tcttttagcc atgctgggaa cggtggttca
    10921 agctgcgggc ttggtagatg atacggtcaa tgtggcaaat gaatacagcc gatacccact
    10981 tgaaaactat caactggatt tttatgtgga taatagctgg ggctggcttc cgtggaactg
    11041 gtcggacggg attggaaaac aggtcatgta tggactatat gccattacca attttatttg
    11101 gacaatcagt ttgtatgttt ccaatgcgac aggttactta gtacaggaag cctattcctt
    11161 agacttcatt tccgctacag cagattccat tggtaagaat atgcagacct tagctggtgt
    11221 gagtgcaaac ggattttcaa cagagggttt ctatgttgga ttcctcttac tcttgatttt
    11281 ggttcttggg gtttatgttg cctatacggg actgataaag agagaaacca caaaggcaat
    11341 tcatgccatt atgaattttg tgctggtgtt tatcctatcg gcttccttta ttgcctacgc
    11401 tcccgactac attaaaaaaa tcaatgactt ttcatcagac atcagtaatg ccagtttatc
    11461 acttggcacg aagattgtca tgccccattc cgatagtcaa ggcaaggaca gcgtggactt
    11521 aatcagagat agcctgtttt ccatacaggt tcagcaaccg tggctactgc ttcaatacaa
    11581 cagttcagac attgaaagta tcggtattga ccgtgtggaa agcctgctct ccaccagccc
    11641 agattccaac aatggcgaag acagagaaaa aattgttgcg gaagaaattg aagacagaag
    11701 caataccaat ctaaccatta caaagaccat taaccgttta ggtacagtct tcttcctatt
    11761 tgtcttcaat attgggattt ccatatttgt attcctatta acaggaatca tgattttctc
    11821 gcaggtactt tttatcatct atgctatgtt tctgcctgtg agctttattt taagcatgat
    11881 tccatcattt gatggtatgt caaaacgagc cataacaaag ctctttaata ccattttgac
    11941 acgagctgga atcacattga ttattacgac agcatttagt atttcaacca tgctctatac
    12001 cttatcggct ggttatccgt tctttttgat tgcttttcta cagattgtga cctttgcagg
    12061 aatctacttc aagctgggcg atttaatgag tatgttttct ctacagagta acgattctca
    12121 aagtgtggga agtcgtgtga tgagaaaacc tcgtatgctt atgcacgctc acatgcaccg
    12181 tctacagcgg aaacttggac gttccatgac tactctaggg gctgggtctg ccattgttac
    12241 aggtaaaaaa ggacagtcgg gttcggggag ttctgcaagg acacaagcag atcactcccg
    12301 accagacgga aaggaaaaat caacacttgg aaaacgtatc ggtcaaacca tcggtacagt
    12361 agctgatacc aaagacagaa tggtagacac tgctagtggt ttgaaagaac aggttaaaga
    12421 tttgccgacc aatgcaagat atgcagtata tcaaggaaaa tccaaagtaa aagagaatgt
    12481 ccgtgattta accagtagta tttctcaaac caaagcggac agagccagtg gacgcaagga
    12541 acagcaggaa caaaggcgaa aaaccattgc gaagcgtcgc tctgaaatgg aacaggtcaa
    12601 acagaaaaaa cagcctgctt cttctgttca tgaaagaccg actacaagac aagaacaata
    12661 tcatgatgaa cagacctcaa aacagtctaa tattcagact tcatataagg aatctcaaca
    12721 agccaaacaa gagcgtccag cagttaagtc cgatttttca agtccaaaag tggaacgcca
    12781 aggcaatacc gttcaagaaa aaaccgttca aaagccagca acttcaacca ctacagcaga
    12841 tagaacttca caacgtccaa tcacaaaaga acgtccgtct actgttcaaa gagtaccact
    12901 acaaaataca agaagtagac caccaatcaa aaccgccacc attaagaaag tcggtaagaa
    12961 accatgaagt tgaaaacttt agtgattggt ggttctggat tattcttgat ggtcttctca
    13021 ctgcttctgt ttgttgccat tttattttca gatgaacagg acagcggaat ttccaatatt
    13081 cattatggag gtgtgaatgt ttccgcagaa gtgctggctc ataagcctat ggtagaaaaa
    13141 tatgccaaag aatatggcgt tgaagaatat gtcaacatac ttcttgcgat tatacaggtg
    13201 gaatcgggcg gtactgcgga agatgttatg cagtcctcgg aatccctcgg tcttccacct
    13261 aattcattga gtacagaaga atccattaag caaggtgtga agtatttcag tgaattatta
    13321 gccagtagcg aaaggctcag tgtagattta gaatcggtta tccagtccta caattatggt
    13381 ggtggtttct tagggtatgt ggctaatcgt ggaaataaat atacctttga actggctcaa
    13441 agtttctcaa aagagtattc aggtggcgaa aaagtgtctt accccaatcc catagccata
    13501 cctatcaatg ggggctggcg atacaactat ggcaatatgt tttatgtgca actggtaacg
    13561 cagtatcttg tcacaacaga gtttgatgat gatacggtac aagccatcat ggacgaagca
    13621 ctgaaatatg agggctggcg atacgtttac ggtggagctt ccccgactac ttcttttgat
    13681 tgtagcggac tgacacaatg gacgtatgga aaagctggaa ttaacttacc acgaaccgca
    13741 caacagcaat atgatgtgac ccagcatatc ccactatcgg aagcacaagc tggcgatttg
    13801 gttttctttc attctaccta taacgctggc tcttatatta ctcatgttgg gatatacctt
    13861 ggcaataacc gtatgtttca tgcaggcgac ccaatcggtt atgccgactt aacaagcccc
    13921 tactggcaac agcatttagt gggagcagga cgaatcaaac aatgagaaag gaagatttaa
    13981 tgatgaaatt tagaaaaaat cagaataaag aaaaacagat accaaaggaa aagaaacctc
    14041 gtgtctacta taaggtcaat cctcataaaa aggttgtgat tgccttgtgg gtacttttag
    14101 ggcttagttt cagctttgcg atattcaagc actttacagc tatagatact catactattc
    14161 acgaaacaac tatcatagaa aaggaatacg ttgatactca tcatgtagaa aattttgtag
    14221 agaactttgc gaaagtctac tattcatggg agcaatccga taagtccatt gataatcgaa
    14281 tggaaagtct aaaaggctat ctgacagatg aacttcaagc tctcaatgtt gatacagtac
    14341 gcaaagatat tcctgtatcg tcttctgtaa gaggatttca gatatggacg gtagagccaa
    14401 ctggcgacaa tgagtttaat gtaacctaca gtgtagacca gctcattaca gagggagaaa
    14461 atacaaagac cgtccactct gcttatatag tgagtgtcta tgtagatggt tctggaaata
    14521 tggtactggt taagaatccg accattacca acatacctaa gaaatcaagt tataaaccaa
    14581 aagccattga aagtgagggg acggttgatt ccattacaac caatgaaatc aatgagtttt
    14641 taacgacgtt cttcaagctc tatcctacag cgacagccag tgaactttcc tactatgtga
    14701 atgacgggat attaaaacca atcggaaaag agtacatctt tcaagaactg gtaaatccta
    14761 ttcacaatcg taaggataat caagtcacgg tatcgctgac agtggagtat atcgaccagc
    14821 agaccaaagc aacgcaggta tctcaatttg atttggtact tgaaaagaac gggagtaatt
    14881 ggaagattat agaataacaa atattggtac attattacag ctattttgta atcacgtact
    14941 ctctttgata aaaaattgga gattccttga caaatatgct cttacgtgct attatttaag
    15001 tatctattta aaaggagtta ataaatatgc ggcaaggtat tcttaaataa actgtcaatt
    15061 tgatagtggg aacaaataat tggatgtcct tttttaggag ggcttagttt tttgtaccca
    15121 gtttaagaat acctttatca tgtgattcta aagtatccgg agaatatctg tatgctttgt
    15181 atgcctatgg ttatgcataa aaatcccagt gataaaagta tttatcactg ggatttttat
    15241 gcccttttgg gtttttgaat ggaggaaaat cacatgaaaa ttattaatat tggagtttta
    15301 gctcatgttg atgcaggaaa aactacctta acagaaagct tattatataa cagtggagcg
    15361 attacagaat taggaagcgt ggacaaaggt acaacgagga cggataatac gcttttagaa
    15421 cgtcagagag gaattacaat tcagacagga ataacctctt ttcagtggga aaatacgaag
    15481 gtgaacatca tagacacgcc aggacatatg gatttcttag cagaagtata tcgttcatta
    15541 tcagttttag atggggcaat tctactgatt tctgcaaaag atggcgtaca agcacaaact
    15601 cgtatattat ttcatgcact taggaaaatg gggattccca caatcttttt tatcaataag
    15661 attgaccaaa atggaattga tttatcaacg gtttatcaga atattaaaga gaaactttct
    15721 gccgaaattg taatcaaaca gaaggtagaa ctgtatccta atatgtgtgt gacgaacttt
    15781 accgaatctg aacaatggga tacggtaata gagggaaacg atgacctttt agagaaatat
    15841 atgtccggta aatcattaga agcattggaa ctcgaacaag aggaaagcat aagatttcag
    15901 aattgttctc tgttccctgt ttatcacgga agtgcaaaaa acaatatagg gattgataac
    15961 cttatagaag tgattacgaa taaattttat tcatcaacac atcgaggtca gtctgaactt
    16021 tgcggaaaag ttttcaaaat tgagtattcg gaaaaaagac agcgtcttgc atatatacgt
    16081 ctttatagtg gcgtactgca tttgcgagat tcggttagaa tatcggaaaa ggaaaaaata
    16141 aaaattacag aaatgtatac ttcaataaat ggtgaattat gtaaaattga taaggcttat
    16201 tccggggaaa ttgttatttt gcagaatgag tttttgaagt taaatagtgt tcttggagat
    16261 acaaagctat tgccacagag agagagaatt gaaaatcccc tccctctgct gcaaacgact
    16321 gttgaaccga gcaaacctca acaaagggaa atgttacttg atgcactttt agaaatctcc
    16381 gacagtgacc cgcttctgcg atattatgtg gattctgcga cacatgaaat catactttct
    16441 ttcttaggga aagtacaaat ggaagtgact tgtgctctgc tgcaagaaaa gtatcatgtg
    16501 gagatagaaa taaaagagcc tacagtcatt tatatggaaa gaccgttaaa aaaagcagag
    16561 tataccattc acatcgaagt tccaccgaat cctttctggg cttccattgg tctatctgta
    16621 gcacagcttc cattagggag cggagtacag tatgagagct cggtttctct tggatactta
    16681 aatcaatcgt ttcaaaatgc agttatggag gggatacgct atggctgtga acaaggattg
    16741 tatggttgga atgtgacgga ctgtaaaatc tgttttaagt atggcttata ctatagccct
    16801 gttagtaccc cagcagattt tcggatgctt gctcctattg tattggaaca agtcttaaaa
    16861 aaagctggaa cagaattgtt agagccatat cttagtttta aaatttatgc gccacaggaa
    16921 tatctttcac gagcatacaa cgatgctcct aaatattgtg cgaacatcgt agacactcaa
    16981 ttgaaaaata atgaggtcat tcttagtgga gaaatccctg ctcggtgtat tcaagaatat
    17041 cgtagtgatt taactttctt tacaaatgga cgtagtgttt gtttaacaga gttaaaaggg
    17101 taccatgtta ctaccggtga acctgtttgc cagccccgtc gtccaaatag tcggatagat
    17161 aaagtacgat atatgttcaa taaaataact tagtgtattt tatgttgtta tataaatatg
    17221 gtttcttgtt aaataagatg aaatattctt taataaagat ttgaattaaa gtgtaaagga
    17281 ggagatagtt attataaata agaggcatat accaattaga attcggaata ctat
//
